GeneModel BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA002131-TA|BGIBMGA002131-PA|IPR002110|Ankyrin,
IPR005821|Ion transport
         (1171 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Y10601-1|CAA71610.1| 1119|Homo sapiens ankyrin-like protein prot...   400   e-110
U50133-1|AAB47805.1| 1856|Homo sapiens ankyrin protein.               190   3e-47
X16609-2|CAA34611.1| 1719|Homo sapiens alt. ankyrin (variant 2.2...   184   1e-45
X16609-1|CAA34610.1| 1881|Homo sapiens protein ( Human mRNA for ...   184   1e-45
M28880-1|AAA51732.1| 1880|Homo sapiens ankyrin protein.               184   1e-45
AB209418-1|BAD92655.1| 1899|Homo sapiens ankyrin 1 isoform 4 var...   184   1e-45
AB002377-1|BAA20833.2| 1059|Homo sapiens KIAA0379 protein protein.    177   2e-43
Z26634-1|CAB42644.1| 3925|Homo sapiens ankyrin B (440 kDa) protein.   175   1e-42
X56958-1|CAA40279.2| 1872|Homo sapiens ankyrin (brank-2) protein.     175   1e-42
BX537758-1|CAD97827.1| 1863|Homo sapiens hypothetical protein pr...   175   1e-42
AK097086-1|BAC04946.1|  919|Homo sapiens protein ( Homo sapiens ...   171   9e-42
AK126888-1|BAC86737.1|  687|Homo sapiens protein ( Homo sapiens ...   164   2e-39
BC114476-1|AAI14477.1|  785|Homo sapiens ANKRD28 protein protein.     162   8e-39
BC113868-1|AAI13869.1|  782|Homo sapiens ANKRD28 protein protein.     162   8e-39
BC106948-1|AAI06949.2|  785|Homo sapiens ANKRD28 protein protein.     162   8e-39
U13616-1|AAA64834.1| 4377|Homo sapiens ankyrin G protein.             161   1e-38
AL592430-3|CAI40518.1| 4372|Homo sapiens ankyrin 3, node of Ranv...   160   2e-38
AL359377-2|CAI41373.1| 4372|Homo sapiens ankyrin 3, node of Ranv...   160   2e-38
AL359267-1|CAH73232.1| 4372|Homo sapiens ankyrin 3, node of Ranv...   160   2e-38
BC016985-1|AAH16985.2|  579|Homo sapiens ANKRD44 protein protein.     156   4e-37
AC013264-1|AAX93155.1|  525|Homo sapiens unknown protein.             156   5e-37
AL592430-2|CAI40517.1| 1071|Homo sapiens ankyrin 3, node of Ranv...   150   3e-35
AL359377-1|CAI41372.1| 1071|Homo sapiens ankyrin 3, node of Ranv...   150   3e-35
U43965-1|AAB08437.1| 1088|Homo sapiens ankyrin G119 protein.          149   8e-35
BC111761-1|AAI11762.1| 1065|Homo sapiens inversin, isoform a pro...   144   2e-33
BC112351-1|AAI12352.1|  725|Homo sapiens INVS protein protein.        143   3e-33
BC041665-1|AAH41665.1|  604|Homo sapiens Similar to inversin pro...   143   3e-33
AL445214-4|CAI39744.1| 1065|Homo sapiens inversin protein.            143   3e-33
AL445214-3|CAI39745.2|  895|Homo sapiens inversin protein.            143   3e-33
AL356798-2|CAI40807.1| 1065|Homo sapiens inversin protein.            143   3e-33
AL356798-1|CAI40808.2|  895|Homo sapiens inversin protein.            143   3e-33
AL137072-3|CAH72173.1| 1065|Homo sapiens inversin protein.            143   3e-33
AL137072-2|CAM16212.1|  895|Homo sapiens inversin protein.            143   3e-33
AF084382-2|AAC79457.1|  895|Homo sapiens inversin protein altern...   143   3e-33
AF084382-1|AAC79456.1| 1065|Homo sapiens inversin protein protein.    143   3e-33
AF084367-1|AAC79436.1| 1065|Homo sapiens inversin protein protein.    143   3e-33
AB033049-1|BAA86537.2| 1089|Homo sapiens KIAA1223 protein protein.    143   3e-33
BX640674-1|CAE45806.1| 1280|Homo sapiens hypothetical protein pr...   142   7e-33
AK127496-1|BAC87007.1| 1375|Homo sapiens protein ( Homo sapiens ...   142   7e-33
AF039217-1|AAD02131.2| 1013|Homo sapiens inv candidate homolog p...   139   6e-32
AY367056-1|AAQ72374.1|  520|Homo sapiens KIAA0379-like protein p...   134   1e-30
BC063622-1|AAH63622.1|  367|Homo sapiens ANKRD44 protein protein.     134   2e-30
BC110618-1|AAI10619.1|  784|Homo sapiens receptor-interacting se...   124   1e-27
BC110617-1|AAI10618.1|  784|Homo sapiens receptor-interacting se...   124   1e-27
BC050586-1|AAH50586.2|  306|Homo sapiens ANKRD44 protein protein.     124   1e-27
AL359707-2|CAC78760.1| 1166|Homo sapiens tankyrase, TRF1-interac...   124   1e-27
AJ278016-1|CAC04247.1|  784|Homo sapiens protein kinase protein.      124   1e-27
AF438201-1|AAL40795.1| 1166|Homo sapiens tankyrase II protein.        124   1e-27
AF342982-1|AAK25811.1| 1166|Homo sapiens tankyrase 2 protein.         124   1e-27
AF329696-1|AAK13463.1| 1166|Homo sapiens tankyrase 2 protein.         124   1e-27
AF309033-1|AAK82330.1| 1166|Homo sapiens tankyrase-2 protein.         124   1e-27
AF264912-1|AAG44694.1| 1166|Homo sapiens tankyrase-like protein ...   124   1e-27
AB047783-1|BAB56136.1|  784|Homo sapiens probable dual-specifici...   124   1e-27
AJ541797-1|CAD62569.2|  765|Homo sapiens ankyrin repeat and kina...   124   2e-27
AF525298-1|AAM91924.1|  765|Homo sapiens X-kinase protein.            124   2e-27
AF487542-1|AAQ09005.1|  765|Homo sapiens protein kinase PKK2 pro...   124   2e-27
AP001743-1|BAA95526.1|  832|Homo sapiens ANKRD3 protein.              124   2e-27
AF305081-1|AAG25674.1| 1265|Homo sapiens tankyrase-related prote...   121   1e-26
AK027424-1|BAB55102.1|  784|Homo sapiens protein ( Homo sapiens ...   119   5e-26
BC098394-1|AAH98394.1| 1327|Homo sapiens tankyrase, TRF1-interac...   119   7e-26
BC024725-1|AAH24725.1|  743|Homo sapiens ANKRD50 protein protein.     119   7e-26
AB209339-1|BAD92576.1| 1055|Homo sapiens tankyrase, TRF1-interac...   119   7e-26
AF082557-1|AAC79842.1| 1094|Homo sapiens TRF1-interacting ankyri...   118   9e-26
AF082556-1|AAC79841.1| 1327|Homo sapiens TRF1-interacting ankyri...   118   9e-26
AB209308-1|BAD92545.1|  931|Homo sapiens ankyrin 3 isoform 1 var...   114   2e-24
AK091555-1|BAC03695.1|  505|Homo sapiens protein ( Homo sapiens ...   109   8e-23
BC101276-1|AAI01277.1|  420|Homo sapiens ANKDD1A protein protein.     106   5e-22
BC101274-1|AAI01275.1|  423|Homo sapiens ANKDD1A protein protein.     106   5e-22
BC101275-1|AAI01276.1|  423|Homo sapiens ANKDD1A protein protein.     105   7e-22
AC017035-2|AAY15060.1|  394|Homo sapiens unknown protein.             103   3e-21
AY281131-1|AAP37612.1| 1249|Homo sapiens AIDA-1b protein.             103   5e-21
BC004173-1|AAH04173.1| 1500|Homo sapiens ANKRD17 protein protein.     102   7e-21
AK025859-1|BAB15260.1|  460|Homo sapiens protein ( Homo sapiens ...   102   7e-21
AB014597-1|BAA31672.2| 2486|Homo sapiens KIAA0697 protein protein.    102   7e-21
AY070436-1|AAL65263.1|  968|Homo sapiens hypothetical protein pr...   100   4e-20
AK074173-1|BAB84999.1| 1486|Homo sapiens FLJ00246 protein protein.    100   4e-20
AK000295-1|BAA91063.1|  686|Homo sapiens protein ( Homo sapiens ...   100   4e-20
AF521883-1|AAO14944.1| 2617|Homo sapiens multiple ankyrin repeat...   100   4e-20
AF521882-1|AAO14943.1| 2542|Homo sapiens multiple ankyrin repeat...   100   4e-20
AF217646-1|AAG41779.1|  532|Homo sapiens hypothetical protein pr...   100   4e-20
DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protei...    99   5e-20
BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protei...    99   5e-20
AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protei...    99   5e-20
AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protei...    99   5e-20
AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protei...    99   5e-20
AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein DK...    99   5e-20
AB033081-1|BAA86569.2| 1232|Homo sapiens KIAA1255 protein protein.     98   2e-19
D86982-1|BAA13218.1| 1180|Homo sapiens KIAA0229 protein.               97   3e-19
BC132832-1|AAI32833.1| 1134|Homo sapiens ankyrin repeat and ster...    97   3e-19
BC022396-1|AAH22396.1|  472|Homo sapiens Unknown (protein for IM...    97   3e-19
AL591002-1|CAI15138.1| 1134|Homo sapiens ankyrin repeat and ster...    97   3e-19
AL138721-1|CAI12437.1| 1134|Homo sapiens ankyrin repeat and ster...    97   3e-19
AL033520-2|CAI20281.1| 1134|Homo sapiens ankyrin repeat and ster...    97   3e-19
AB037360-1|BAA90300.1| 1166|Homo sapiens ANKHZN protein.               97   3e-19
AF308285-1|AAG48253.1| 1188|Homo sapiens serologically defined b...    97   4e-19
BC101273-1|AAI01274.1|  399|Homo sapiens ANKDD1A protein protein.      96   6e-19
BC110582-1|AAI10583.1| 1006|Homo sapiens mindbomb homolog 1 (Dro...    95   1e-18
BC110581-1|AAI10582.1| 1006|Homo sapiens mindbomb homolog 1 (Dro...    95   1e-18
AY149908-1|AAN75493.1| 1006|Homo sapiens mind bomb protein.            95   1e-18
AY147849-1|AAN18023.1|  997|Homo sapiens MINDBOMB protein.             95   1e-18
BC130610-1|AAI30611.1| 1672|Homo sapiens KIDINS220 protein protein.    95   1e-18
BC032354-1|AAH32354.1|  587|Homo sapiens ankyrin repeat and SOCS...    95   1e-18
AJ251238-1|CAC17765.1|  587|Homo sapiens hypothetical protein pr...    95   1e-18
AB056723-1|BAB64532.1|  587|Homo sapiens ankyrin repeat-conteini...    95   1e-18
AB033076-1|BAA86564.2| 1777|Homo sapiens KIAA1250 protein protein.     95   1e-18
AL133620-1|CAB63746.1| 1031|Homo sapiens hypothetical protein pr...    94   2e-18
BC043394-1|AAH43394.1|  751|Homo sapiens ANKRD17 protein protein.      93   4e-18
BC007747-1|AAH07747.2|  830|Homo sapiens ANKRD17 protein protein.      93   4e-18
AL159174-1|CAI39609.1|  692|Homo sapiens ankyrin repeat domain 6...    93   4e-18
AL096678-2|CAI42280.1|  692|Homo sapiens ankyrin repeat domain 6...    93   4e-18
AF451977-1|AAL49758.1| 1431|Homo sapiens cask-interacting protei...    93   4e-18
AB023174-1|BAA76801.2|  693|Homo sapiens KIAA0957 protein protein.     93   5e-18
AB046856-1|BAB13462.2| 1864|Homo sapiens KIAA1636 protein protein.     92   9e-18
AK124559-1|BAC85884.1| 1005|Homo sapiens protein ( Homo sapiens ...    92   1e-17
AF159164-1|AAD45345.1|  544|Homo sapiens ankyrin repeat-containi...    92   1e-17
X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein.             91   2e-17
BC042173-1|AAH42173.1|  722|Homo sapiens ankyrin repeat domain 6...    91   2e-17
BC110915-1|AAI10916.1|  553|Homo sapiens ASB3 protein protein.         90   4e-17
BC009569-1|AAH09569.1|  518|Homo sapiens ankyrin repeat and SOCS...    90   4e-17
BC006488-1|AAH06488.1|  518|Homo sapiens ankyrin repeat and SOCS...    90   4e-17
AK000985-1|BAA91455.1|  518|Homo sapiens protein ( Homo sapiens ...    90   4e-17
AF156778-1|AAD41895.1|  518|Homo sapiens ASB-3 protein protein.        90   4e-17
AC007883-1|AAY24350.1|  326|Homo sapiens unknown protein.              90   4e-17
AB209795-1|BAD93032.1|  340|Homo sapiens ankyrin repeat and SOCS...    90   4e-17
AB051515-1|BAB21819.1| 1644|Homo sapiens KIAA1728 protein protein.     90   5e-17
BC066643-1|AAH66643.1| 1202|Homo sapiens CASK interacting protei...    88   2e-16
AF451976-1|AAL49757.1| 1202|Homo sapiens cask-interacting protei...    88   2e-16
AK222715-1|BAD96435.1|  512|Homo sapiens ankyrin repeat and SOCS...    88   2e-16
D83197-1|BAA34594.1|  226|Homo sapiens gankyrin protein.               87   5e-16
BC011960-1|AAH11960.1|  226|Homo sapiens proteasome (prosome, ma...    87   5e-16
AL031177-5|CAA20117.1|  226|Homo sapiens proteasome (prosome, ma...    87   5e-16
AK098479-1|BAC05314.1|  353|Homo sapiens protein ( Homo sapiens ...    87   5e-16
AB009619-1|BAA33215.1|  226|Homo sapiens 26S proteasome subunit ...    87   5e-16
BT019689-1|AAV38495.1|  226|Homo sapiens proteasome (prosome, ma...    86   6e-16
AK222595-1|BAD96315.1|  518|Homo sapiens ankyrin repeat and SOCS...    86   8e-16
AB032965-1|BAA86453.1| 1124|Homo sapiens KIAA1139 protein protein.     86   8e-16
DQ822519-1|ABG46944.1|  835|Homo sapiens TNNI3 interacting kinas...    85   1e-15
BX470253-1|CAI16293.1|  835|Homo sapiens TNNI3 interacting kinas...    85   1e-15
BC117262-1|AAI17263.1|  835|Homo sapiens TNNI3 interacting kinas...    85   1e-15
BC113539-1|AAI13540.1|  835|Homo sapiens TNNI3 interacting kinas...    85   1e-15
AY303691-1|AAP72030.1|  835|Homo sapiens cardiac ankyrin repeat ...    85   1e-15
AJ278120-1|CAB92314.1| 1101|Homo sapiens putative ankyrin-repeat...    85   1e-15
AF116826-1|AAD29632.1|  835|Homo sapiens putative protein-tyrosi...    85   1e-15
AB208941-1|BAD92178.1|  941|Homo sapiens TNNI3 interacting kinas...    85   1e-15
BC127127-1|AAI27128.1|  627|Homo sapiens ankyrin repeat and KH d...    85   1e-15
BC117677-1|AAI17678.1|  627|Homo sapiens ankyrin repeat and KH d...    85   1e-15
BC034982-1|AAH34982.1|  909|Homo sapiens HECT domain and ankyrin...    85   1e-15
BC032865-1|AAH32865.1|  843|Homo sapiens TNNI3K protein protein.       85   1e-15
BC009909-1|AAH09909.1|  627|Homo sapiens ankyrin repeat and KH d...    85   1e-15
BC009420-1|AAH09420.1|  616|Homo sapiens ankyrin repeat and KH d...    85   1e-15
BC004457-1|AAH04457.2|  627|Homo sapiens ankyrin repeat and KH d...    85   1e-15
AK022041-1|BAB13958.1|  435|Homo sapiens protein ( Homo sapiens ...    85   1e-15
AF258557-1|AAG23760.1|  627|Homo sapiens PP2500 protein.               85   1e-15
AL158217-11|CAI22163.1|  854|Homo sapiens espin protein.               84   2e-15
AL031848-3|CAI19773.1|  854|Homo sapiens espin protein.                84   2e-15
BX640903-1|CAE45949.1|  714|Homo sapiens hypothetical protein pr...    83   4e-15
X69838-1|CAA49491.1| 1001|Homo sapiens G9a protein.                    83   6e-15
BX005460-6|CAM26152.1|  922|Homo sapiens euchromatic histone-lys...    83   6e-15
BX005460-5|CAM26151.1|  888|Homo sapiens euchromatic histone-lys...    83   6e-15
BC020970-1|AAH20970.2| 1198|Homo sapiens EHMT2 protein protein.        83   6e-15
BC018718-1|AAH18718.1| 1001|Homo sapiens EHMT2 protein protein.        83   6e-15
BC009351-1|AAH09351.1| 1209|Homo sapiens EHMT2 protein protein.        83   6e-15
BC002686-1|AAH02686.2| 1043|Homo sapiens EHMT2 protein protein.        83   6e-15
BA000025-4|BAB63295.1| 1001|Homo sapiens G9A protein.                  83   6e-15
AL844853-4|CAI41853.1| 1210|Homo sapiens HLA-B associated transc...    83   6e-15
AL844853-3|CAI41852.1| 1176|Homo sapiens HLA-B associated transc...    83   6e-15
AL671762-16|CAI18224.2| 1210|Homo sapiens euchromatic histone-ly...    83   6e-15
AL671762-15|CAI18226.2| 1176|Homo sapiens euchromatic histone-ly...    83   6e-15
AL671762-14|CAM25534.1| 1267|Homo sapiens euchromatic histone-ly...    83   6e-15
AL671762-13|CAM25533.1| 1233|Homo sapiens euchromatic histone-ly...    83   6e-15
AL662834-27|CAI17747.2| 1176|Homo sapiens euchromatic histone-ly...    83   6e-15
AL662834-26|CAI17748.1| 1210|Homo sapiens euchromatic histone-ly...    83   6e-15
AL662834-25|CAM24993.1| 1267|Homo sapiens euchromatic histone-ly...    83   6e-15
AL662834-24|CAM24992.1| 1233|Homo sapiens euchromatic histone-ly...    83   6e-15
AJ315532-1|CAC86666.1| 1210|Homo sapiens NG36/G9a protein.             83   6e-15
AF134726-3|AAD21812.1| 1001|Homo sapiens G9A protein.                  83   6e-15
BC011608-1|AAH11608.2|  716|Homo sapiens EHMT1 protein protein.        81   2e-14
AY083210-1|AAM09024.1| 1267|Homo sapiens euchromatic histone met...    81   2e-14
AL611925-3|CAH71077.1| 1267|Homo sapiens euchromatic histone-lys...    81   2e-14
AL590627-3|CAI17355.1| 1267|Homo sapiens euchromatic histone-lys...    81   2e-14
AB058779-1|BAB47505.2|  803|Homo sapiens KIAA1876 protein protein.     81   2e-14
AB028932-1|BAB56104.1|  917|Homo sapiens GLP1 protein.                 81   2e-14
DQ508815-1|ABF60230.1|  593|Homo sapiens SARP protein.                 81   3e-14
AK095193-1|BAC04496.1|  389|Homo sapiens protein ( Homo sapiens ...    80   4e-14
BC117678-1|AAI17679.1|  581|Homo sapiens ANKHD1 protein protein.       79   7e-14
BC062346-1|AAH62346.1|  361|Homo sapiens ankyrin repeat domain 1...    79   7e-14
AL137186-4|CAI41072.1|  361|Homo sapiens ankyrin repeat domain 1...    79   7e-14
AL035288-1|CAA22892.1|  671|Homo sapiens hypothetical protein pr...    79   9e-14
AL021920-3|CAI19632.1|  671|Homo sapiens espin pseudogene protein.     79   9e-14
AK127855-1|BAC87163.1|  337|Homo sapiens protein ( Homo sapiens ...    79   9e-14
BX005460-4|CAM26150.1|  297|Homo sapiens euchromatic histone-lys...    79   1e-13
AL671762-12|CAI18225.2|  297|Homo sapiens euchromatic histone-ly...    79   1e-13
AL662834-23|CAM24991.1|  297|Homo sapiens euchromatic histone-ly...    79   1e-13
BC050324-1|AAH50324.1|  632|Homo sapiens zinc finger, DHHC-type ...    77   3e-13
AB097035-1|BAC77388.1|  622|Homo sapiens putative MAPK activatin...    77   3e-13
AB097013-1|BAC77366.1|  622|Homo sapiens putative NFkB activatin...    77   3e-13
AB023163-1|BAA76790.1|  667|Homo sapiens KIAA0946 protein protein.     77   3e-13
EF041819-1|ABL09300.1|  782|Homo sapiens several ankyrin repeat ...    77   5e-13
AL590402-2|CAH74024.1|  903|Homo sapiens HECT domain and ankyrin...    77   5e-13
AL513472-2|CAH71890.1|  903|Homo sapiens HECT domain and ankyrin...    77   5e-13
AL357315-1|CAI16815.1|  903|Homo sapiens HECT domain and ankyrin...    77   5e-13
AK001283-1|BAA91599.1|  445|Homo sapiens protein ( Homo sapiens ...    77   5e-13
AB209433-1|BAD92670.1| 1031|Homo sapiens HLA-B associated transc...    75   1e-12
DQ508934-1|ABF57994.1|  591|Homo sapiens SARP3 protein.                75   2e-12
CR457302-1|CAG33583.1|  278|Homo sapiens ASB13 protein.                74   3e-12
BC126351-1|AAI26352.1|  467|Homo sapiens ASB10 protein protein.        74   3e-12
AL365356-2|CAH72614.1|  278|Homo sapiens ankyrin repeat and SOCS...    74   3e-12
AK125565-1|BAC86204.1|  452|Homo sapiens protein ( Homo sapiens ...    74   3e-12
AF417920-1|AAL59159.1|  429|Homo sapiens ASB-10 protein.               74   3e-12
AF403031-1|AAL57350.1|  286|Homo sapiens ankyrin repeat domain-c...    74   3e-12
BC050529-1|AAH50529.1| 1050|Homo sapiens ankyrin repeat domain 2...    74   3e-12
BC030990-1|AAH30990.1|  276|Homo sapiens ZDHHC17 protein protein.      74   3e-12
AL834335-1|CAD39003.1|  407|Homo sapiens hypothetical protein pr...    74   3e-12
AK054561-1|BAB70755.1| 1060|Homo sapiens FLJ00040 protein protein.     74   3e-12
BC110907-1|AAI10908.1|  515|Homo sapiens PPP1R12B protein protein.     73   5e-12
BC034430-1|AAH34430.1|  386|Homo sapiens PPP1R12B protein protein.     73   5e-12
AL589762-3|CAH73375.1|  982|Homo sapiens protein phosphatase 1, ...    73   5e-12
AL589762-2|CAH73374.1|  386|Homo sapiens protein phosphatase 1, ...    73   5e-12
AL356953-9|CAI15935.1|  982|Homo sapiens protein phosphatase 1, ...    73   5e-12
AL356953-8|CAI15934.1|  386|Homo sapiens protein phosphatase 1, ...    73   5e-12
AB024494-1|BAC22089.1|  633|Homo sapiens huntingtin interacting ...    73   5e-12
AK023196-1|BAB14456.1|  278|Homo sapiens ARPP-19) mRNA.  protein.      73   6e-12
AF324892-1|AAK00336.1|  982|Homo sapiens myosin phosphatase targ...    73   6e-12
AF324888-1|AAK00337.1|  982|Homo sapiens myosin phosphatase targ...    73   6e-12
AB003062-1|BAA28376.1|  982|Homo sapiens myosin phosphatase targ...    73   6e-12
BC030622-1|AAH30622.1|  301|Homo sapiens ankyrin repeat domain 2...    73   8e-12
X61498-1|CAA43715.1|  933|Homo sapiens NF-kB subunit protein.          72   1e-11
S76638-1|AAB21124.1|  900|Homo sapiens p50-NF-kappa B homolog pr...    72   1e-11
BT009769-1|AAP88771.1|  899|Homo sapiens nuclear factor of kappa...    72   1e-11
BC002844-1|AAH02844.1|  899|Homo sapiens nuclear factor of kappa...    72   1e-11
AY865619-1|AAW56071.1|  900|Homo sapiens nuclear factor of kappa...    72   1e-11
AL121928-1|CAC08399.1|  900|Homo sapiens nuclear factor of kappa...    72   1e-11
BC101620-1|AAI01621.1| 1001|Homo sapiens ankyrin repeat domain 3...    71   2e-11
BC101618-1|AAI01619.1| 1001|Homo sapiens ankyrin repeat domain 3...    71   2e-11
M58603-1|AAA36360.1|  968|Homo sapiens nuclear factor kappa-B DN...    70   4e-11
M55643-1|AAA36361.1|  969|Homo sapiens factor KBF1 protein.            70   4e-11
BC051765-1|AAH51765.1|  969|Homo sapiens nuclear factor of kappa...    70   4e-11
BC037542-1|AAH37542.1|  999|Homo sapiens MIB2 protein protein.         70   4e-11
BC033210-1|AAH33210.1|  550|Homo sapiens NFKB1 protein protein.        70   4e-11
BC016490-1|AAH16490.1| 1030|Homo sapiens MIB2 protein protein.         70   4e-11
AY223820-1|AAO30127.1|  968|Homo sapiens nuclear factor of kappa...    70   4e-11
AL691432-4|CAM12833.1|  919|Homo sapiens mindbomb homolog 2 (Dro...    70   4e-11
AL691432-3|CAM12832.1|  753|Homo sapiens mindbomb homolog 2 (Dro...    70   4e-11
AL691432-2|CAM12831.1|  999|Homo sapiens mindbomb homolog 2 (Dro...    70   4e-11
AL691432-1|CAM12830.1|  948|Homo sapiens mindbomb homolog 2 (Dro...    70   4e-11
AL031177-4|CAI43134.1|  193|Homo sapiens proteasome (prosome, ma...    70   4e-11
AK098785-1|BAC05413.1|  802|Homo sapiens protein ( Homo sapiens ...    70   4e-11
AK097106-1|BAC04952.1|  819|Homo sapiens protein ( Homo sapiens ...    70   4e-11
AK095914-1|BAC04646.1|  681|Homo sapiens protein ( Homo sapiens ...    70   4e-11
AK091610-1|BAC03707.1|  645|Homo sapiens protein ( Homo sapiens ...    70   4e-11
AK091120-1|BAC03587.1| 1001|Homo sapiens protein ( Homo sapiens ...    70   4e-11
AF213884-1|AAF35232.1|  968|Homo sapiens nuclear factor of kappa...    70   4e-11
AB097000-1|BAC77353.1|  999|Homo sapiens putative NFkB activatin...    70   4e-11
AB076693-1|BAC00994.1| 1009|Homo sapiens skeletrophin gamma prot...    70   4e-11
AB076692-1|BAC00993.1|  948|Homo sapiens skeletrophin beta protein.    70   4e-11
AB076691-1|BAC00992.1|  999|Homo sapiens skeletrophin alpha prot...    70   4e-11
AB074480-1|BAB92950.1| 1013|Homo sapiens skeletrophin protein.         70   4e-11
AK096295-1|BAC04752.1|  681|Homo sapiens protein ( Homo sapiens ...    70   6e-11
D87930-1|BAA22378.1| 1030|Homo sapiens myosin phosphatase target...    69   1e-10
BC111752-1|AAI11753.1| 1030|Homo sapiens PPP1R12A protein protein.     69   1e-10
BC092481-1|AAH92481.1|  730|Homo sapiens PPP1R12A protein protein.     69   1e-10
BC052988-1|AAH52988.1|  980|Homo sapiens retinoic acid induced 1...    69   1e-10
BC047898-1|AAH47898.1|  692|Homo sapiens PPP1R12A protein protein.     69   1e-10
AY380574-1|AAQ88438.1|  974|Homo sapiens myosin phosphatase targ...    69   1e-10
AY354204-1|AAQ63889.2|  972|Homo sapiens retinoic acid induced 1...    69   1e-10
AY317139-1|AAP84319.1|  983|Homo sapiens RAI14 isoform protein.        69   1e-10
AF458589-1|AAM49717.1|  995|Homo sapiens myosin phosphatase targ...    69   1e-10
AB037755-1|BAA92572.1|  989|Homo sapiens KIAA1334 protein protein.     69   1e-10
Z47748-1|CAB94757.1|  969|Homo sapiens NFKB1 protein.                  69   1e-10
U40282-1|AAC16892.1|  452|Homo sapiens integrin-linked kinase pr...    69   1e-10
CR407673-1|CAG28601.1|  452|Homo sapiens ILK protein.                  69   1e-10
BC001554-1|AAH01554.1|  452|Homo sapiens integrin-linked kinase ...    69   1e-10
AJ404847-1|CAB99253.1|  452|Homo sapiens integrin-linked kinase ...    69   1e-10
AJ277481-1|CAB94832.1|  452|Homo sapiens integrin-linked kinase-...    69   1e-10
AF244139-1|AAF74449.1|  452|Homo sapiens integrin-linked kinase ...    69   1e-10
AF155135-1|AAF44722.1|  980|Homo sapiens novel retinal pigment e...    69   1e-10
BC004988-1|AAH04988.1|  669|Homo sapiens fem-1 homolog a (C. ele...    68   2e-10
AY356352-1|AAR10439.1|  669|Homo sapiens prostaglandin E recepto...    68   2e-10
AJ311359-1|CAC85342.1|  668|Homo sapiens putative sex determinin...    68   2e-10
M73980-1|AAA60614.1| 2444|Homo sapiens TAN1 protein.                   68   2e-10
BC012056-1|AAH12056.1|  173|Homo sapiens ASB13 protein protein.        68   2e-10
AL592301-5|CAI13934.1| 2555|Homo sapiens Notch homolog 1, transl...    68   2e-10
AL354671-1|CAI16149.1| 2555|Homo sapiens Notch homolog 1, transl...    68   2e-10
AF308602-1|AAG33848.1| 2556|Homo sapiens NOTCH 1 protein.              68   2e-10
AB209873-1|BAD93110.1| 2067|Homo sapiens notch1 preproprotein va...    68   2e-10
AK057782-1|BAB71569.1|  268|Homo sapiens protein ( Homo sapiens ...    67   3e-10
AF403033-1|AAL57352.1|  434|Homo sapiens ankyrin repeat domain-c...    67   3e-10
BC028369-1|AAH28369.1|  617|Homo sapiens fem-1 homolog c (C. ele...    67   4e-10
AY249188-1|AAO64429.1|  617|Homo sapiens FEM1C protein.                67   4e-10
AL365415-1|CAB96957.1|  271|Homo sapiens similar to (NP_034322.1...    67   4e-10
AF391093-1|AAL37627.1|  617|Homo sapiens FEM1A protein.                67   4e-10
AB058688-1|BAB47414.1|  617|Homo sapiens KIAA1785 protein protein.     67   4e-10
BC008782-1|AAH08782.1| 1219|Homo sapiens nuclear factor of kappa...    66   5e-10
AJ249601-1|CAB63467.1|  559|Homo sapiens IkappaBR protein.             66   5e-10
AB209126-1|BAD92363.1|  897|Homo sapiens I-kappa-B-related prote...    66   5e-10
BX537853-1|CAD97861.1|  302|Homo sapiens hypothetical protein pr...    66   7e-10
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ...    66   7e-10
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ...    66   7e-10
BC103875-1|AAI03876.1|  323|Homo sapiens ankyrin repeat and SOCS...    66   7e-10
BC103874-1|AAI03875.1|  323|Homo sapiens ankyrin repeat and SOCS...    66   7e-10
BC069340-1|AAH69340.1|  323|Homo sapiens ankyrin repeat and SOCS...    66   7e-10
BC016881-1|AAH16881.1|  638|Homo sapiens Unknown (protein for IM...    66   7e-10
BC013172-1|AAH13172.1|  294|Homo sapiens ankyrin repeat and SOCS...    66   7e-10
AK055435-1|BAB70922.1|  634|Homo sapiens protein ( Homo sapiens ...    66   7e-10
AK000643-1|BAA91302.1|  262|Homo sapiens protein ( Homo sapiens ...    66   7e-10
AF425642-1|AAL60519.1|  323|Homo sapiens ankyrin repeat domain-c...    66   7e-10
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein.     66   7e-10
U49399-1|AAB03772.1|  166|Homo sapiens INK4d protein.                  66   9e-10
U40343-1|AAB18139.1|  166|Homo sapiens p19INK4d protein.               66   9e-10
U20498-1|AAA85436.1|  166|Homo sapiens p19 protein protein.            66   9e-10
CR542158-1|CAG46955.1|  166|Homo sapiens CDKN2D protein.               66   9e-10
BC063581-1|AAH63581.1|  274|Homo sapiens ankyrin repeat and SOCS...    66   9e-10
BC001822-1|AAH01822.1|  166|Homo sapiens cyclin-dependent kinase...    66   9e-10
AF518878-1|AAM54045.1|  166|Homo sapiens cyclin-dependent kinase...    66   9e-10
AF451994-1|AAP97683.1|  318|Homo sapiens ankyrin repeat-containi...    66   9e-10
AF061327-1|AAC27450.1|  166|Homo sapiens cyclin-dependent kinase...    66   9e-10
BC065710-1|AAH65710.1|  329|Homo sapiens ankyrin repeat and SOCS...    65   1e-09
AY057053-1|AAL18248.1|  329|Homo sapiens SOCS box protein ASB-5 ...    65   1e-09
AL159174-2|CAI39610.1|  640|Homo sapiens ankyrin repeat domain 6...    65   1e-09
AL096678-3|CAI42281.1|  640|Homo sapiens ankyrin repeat domain 6...    65   1e-09
AL080091-1|CAB45706.2|  266|Homo sapiens hypothetical protein pr...    65   1e-09
AK222974-1|BAD96694.1|  274|Homo sapiens ankyrin repeat and SOCS...    65   1e-09
AK222958-1|BAD96678.1|  274|Homo sapiens ankyrin repeat and SOCS...    65   1e-09
AK125360-1|BAC86146.1|  588|Homo sapiens protein ( Homo sapiens ...    65   1e-09
AK098693-1|BAC05382.1|  276|Homo sapiens protein ( Homo sapiens ...    65   1e-09
AK096441-1|BAC04791.1|  329|Homo sapiens protein ( Homo sapiens ...    65   1e-09
AK026204-1|BAB15392.1|  274|Homo sapiens protein ( Homo sapiens ...    65   1e-09
AB075861-1|BAB85567.1|  863|Homo sapiens KIAA1981 protein protein.     65   1e-09
X83703-1|CAA58676.1|  319|Homo sapiens nuclear protein protein.        65   2e-09
BC018667-1|AAH18667.1|  319|Homo sapiens ankyrin repeat domain 1...    65   2e-09
AY903446-1|AAX23581.1|  319|Homo sapiens liver ankyrin repeat do...    65   2e-09
AL590622-4|CAC70101.1|  319|Homo sapiens ankyrin repeat domain 1...    65   2e-09
U16258-1|AAA85819.1|  481|Homo sapiens I kappa BR protein.             64   3e-09
AL117504-1|CAB55968.1|  641|Homo sapiens hypothetical protein pr...    64   3e-09
BC070234-1|AAH70234.1|  371|Homo sapiens ANKRD12 protein protein.      64   4e-09
AY533564-1|AAS45545.2| 2039|Homo sapiens ankyrin repeat-containi...    64   4e-09
AY373757-1|AAR25662.1| 2062|Homo sapiens ankyrin repeat-containi...    64   4e-09
AL442128-2|CAH73039.1|  420|Homo sapiens ankyrin repeat domain 1...    64   4e-09
AL157875-2|CAH70238.1|  420|Homo sapiens ankyrin repeat domain 1...    64   4e-09
AK024808-1|BAB15014.1|  492|Homo sapiens protein ( Homo sapiens ...    64   4e-09
AF317425-1|AAG38609.1| 2062|Homo sapiens GAC-1 protein.                64   4e-09
U97669-1|AAB91371.1| 2321|Homo sapiens Notch3 protein.                 63   6e-09
BC051904-1|AAH51904.1|  752|Homo sapiens phospholipase A2, group...    63   6e-09
AK000100-1|BAA90945.1|  420|Homo sapiens protein ( Homo sapiens ...    63   6e-09
AF102988-1|AAD41722.1|  752|Homo sapiens Ca2+-independent phosph...    63   6e-09
AF058900-1|AAC14346.1| 2321|Homo sapiens Notch3 protein.               63   6e-09
AC004663-1|AAC15789.1| 2281|Homo sapiens Notch 3 protein.              63   6e-09
U05681-1|AAC51348.1|  368|Homo sapiens B-cell leukemia/lymphoma ...    62   9e-09
M31732-1|AAA51815.1|  446|Homo sapiens BCL3 protein.                   62   9e-09
CR542199-1|CAG46996.1|  260|Homo sapiens RFXANK protein.               62   9e-09
CR456981-1|CAG33262.1|  260|Homo sapiens RFXANK protein.               62   9e-09
BC114563-1|AAI14564.1|  260|Homo sapiens regulatory factor X-ass...    62   9e-09
BC064993-1|AAH64993.1|  446|Homo sapiens B-cell CLL/lymphoma 3 p...    62   9e-09
BC057225-1|AAH57225.1|  330|Homo sapiens ANKRD12 protein protein.      62   9e-09
AF105427-1|AAD17972.1|  260|Homo sapiens transcription factor RF...    62   9e-09
AF094760-1|AAC69883.1|  260|Homo sapiens RFXANK protein.               62   9e-09
AC003110-1|AAB86654.1|  196|Homo sapiens F14150_1 protein.             62   9e-09
M69043-1|AAA16489.1|  317|Homo sapiens MAD3 protein.                   62   1e-08
BT007091-1|AAP35754.1|  317|Homo sapiens nuclear factor of kappa...    62   1e-08
BC056152-1|AAH56152.1|  622|Homo sapiens zinc finger, DHHC-type ...    62   1e-08
BC004983-1|AAH04983.1|  317|Homo sapiens nuclear factor of kappa...    62   1e-08
BC002601-1|AAH02601.1|  317|Homo sapiens nuclear factor of kappa...    62   1e-08
AY496422-1|AAR29599.1|  317|Homo sapiens nuclear factor of kappa...    62   1e-08
AY033600-1|AAK51149.1|  317|Homo sapiens NFKBIA protein.               62   1e-08
AL357148-2|CAI16567.1| 1341|Homo sapiens breast cancer antigen N...    62   1e-08
AL357148-1|CAI16568.1| 1460|Homo sapiens ankyrin repeat domain 3...    62   1e-08
AL157387-4|CAH71319.1| 1460|Homo sapiens ankyrin repeat domain 3...    62   1e-08
AL157387-3|CAH71320.1| 1341|Homo sapiens breast cancer antigen N...    62   1e-08
AJ249294-1|CAB65556.2|  317|Homo sapiens IkBa protein.                 62   1e-08
AB097027-1|BAC77380.1|  622|Homo sapiens putative MAPK activatin...    62   1e-08
AB097014-1|BAC77367.1|  622|Homo sapiens putative NFkB activatin...    62   1e-08
BC036020-1|AAH36020.1|  622|Homo sapiens zinc finger, DHHC-type ...    62   2e-08
AY057056-1|AAL25260.1|  151|Homo sapiens hepatocellular carcinom...    62   2e-08
AL031177-6|CAI43131.1|  151|Homo sapiens proteasome (prosome, ma...    62   2e-08
AK001714-1|BAA91856.1|  481|Homo sapiens protein ( Homo sapiens ...    62   2e-08
AB024495-1|BAC22090.1|  622|Homo sapiens huntingtin interacting ...    62   2e-08
Z97630-4|CAB63057.1|  300|Homo sapiens protein ( Human DNA seque...    61   2e-08
CR456471-1|CAG30357.1|  300|Homo sapiens dJ466N1.4 protein.            61   2e-08
BC107056-1|AAI07057.1|  305|Homo sapiens ankyrin repeat domain 2...    61   2e-08
BC066909-1|AAH66909.1|  300|Homo sapiens ankyrin repeat domain 5...    61   2e-08
BC060843-1|AAH60843.1|  228|Homo sapiens ANKRD46 protein protein.      61   2e-08
BC050396-1|AAH50396.1|  232|Homo sapiens ANKRD46 protein protein.      61   2e-08
BC014641-1|AAH14641.1|  300|Homo sapiens ankyrin repeat domain 5...    61   2e-08
AY196212-1|AAO40750.1|  305|Homo sapiens muscle ankyrin repeat p...    61   2e-08
AK098736-1|BAC05399.1|  181|Homo sapiens protein ( Homo sapiens ...    61   2e-08
AJ315766-1|CAC86120.1|  296|Homo sapiens Ankyrin repeat-containi...    61   2e-08
AF492401-1|AAO24067.1|  305|Homo sapiens diabetes related ankyri...    61   2e-08
AF269087-1|AAK27325.1| 1341|Homo sapiens breast cancer antigen N...    61   2e-08
AC092636-3|AAY14965.1|  305|Homo sapiens unknown protein.              61   2e-08
AB077205-1|BAD23947.1|  228|Homo sapiens ankyrin repeat small pr...    61   2e-08
U95299-1|AAC32288.1| 2003|Homo sapiens Notch4 protein.                 61   3e-08
U89335-1|AAC63097.1| 1999|Homo sapiens notch4 protein.                 61   3e-08
D63395-1|BAA09708.1| 1095|Homo sapiens notch related protein pro...    61   3e-08
DQ388145-2|ABD72216.1| 1482|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388144-2|ABD72214.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388143-2|ABD72212.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388142-2|ABD72210.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388141-2|ABD72208.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388140-2|ABD72206.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388139-2|ABD72204.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388138-2|ABD72202.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388137-2|ABD72200.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388136-2|ABD72198.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388135-2|ABD72196.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388134-2|ABD72194.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388133-2|ABD72192.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388132-2|ABD72190.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388131-2|ABD72188.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388130-2|ABD72186.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388129-2|ABD72184.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ388128-2|ABD72182.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356264-2|ABC87066.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356263-2|ABC87064.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356262-2|ABC87062.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356261-2|ABC87060.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356260-2|ABC87058.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356259-2|ABC87056.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356258-2|ABC87054.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ356257-2|ABC87052.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ354391-2|ABC79055.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ354390-2|ABC79053.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ354389-2|ABC79051.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
DQ354388-2|ABC79049.1| 1663|Homo sapiens CTTNBP2 protein.              61   3e-08
CR456543-1|CAG30429.1|  806|Homo sapiens PLA2G6 protein.               61   3e-08
BX284927-1|CAM25850.1| 2003|Homo sapiens Notch homolog 4 (Drosop...    61   3e-08
BX284686-1|CAM26209.1| 2003|Homo sapiens Notch homolog 4 (Drosop...    61   3e-08
BC114558-1|AAI14559.1|  238|Homo sapiens regulatory factor X-ass...    61   3e-08
BC107759-1|AAI07760.1|  360|Homo sapiens ankyrin repeat domain 2...    61   3e-08
BC106000-1|AAI06001.1| 1663|Homo sapiens cortactin binding prote...    61   3e-08
BC036742-1|AAH36742.2|  806|Homo sapiens phospholipase A2, group...    61   3e-08
BC028407-1|AAH28407.1|  619|Homo sapiens ankyrin repeat domain 3...    61   3e-08
AY522921-1|AAR92478.1|  806|Homo sapiens phospholipase A2, group...    61   3e-08
AL845509-1|CAI18564.1| 2003|Homo sapiens Notch homolog 4 (Drosop...    61   3e-08
AL845464-12|CAI41803.1| 2003|Homo sapiens Notch homolog 4 (Droso...    61   3e-08
AL662884-27|CAI18362.1| 2003|Homo sapiens Notch homolog 4 (Droso...    61   3e-08
AL662830-9|CAI17543.1| 2005|Homo sapiens Notch homolog 4 (Drosop...    61   3e-08
AL359388-4|CAI14194.1|  333|Homo sapiens ankyrin repeat domain 2...    61   3e-08
AL355315-9|CAI15463.1|  333|Homo sapiens ankyrin repeat domain 2...    61   3e-08
AL137614-1|CAB70843.1|  160|Homo sapiens hypothetical protein pr...    61   3e-08
AL022322-2|CAA18446.1|  806|Homo sapiens phospholipase A2, group...    61   3e-08
AJ583444-1|CAE47432.1|  449|Homo sapiens ankyrin repeat protein ...    61   3e-08
AJ304805-1|CAC19412.1|  333|Homo sapiens skeletal muscle ankyrin...    61   3e-08
AJ304804-1|CAC19411.1|  333|Homo sapiens skeletal muscle ankyrin...    61   3e-08
AF377960-1|AAL32176.1| 1663|Homo sapiens cortactin-binding prote...    61   3e-08
AF117692-1|AAD30424.1|  806|Homo sapiens calcium-independent pho...    61   3e-08
AF116267-1|AAF34728.1|  806|Homo sapiens calcium-independent pho...    61   3e-08
AF105428-1|AAD17973.1|  237|Homo sapiens putative protein RFX-Bd...    61   3e-08
AF102989-1|AAD41723.1|  806|Homo sapiens Ca2+-independent phosph...    61   3e-08
AF064594-1|AAC97486.1|  806|Homo sapiens calcium-independent pho...    61   3e-08
AB058599-1|BAB60958.1|  333|Homo sapiens ankyrin-repeat protein ...    61   3e-08
AB051545-1|BAB21849.1| 1662|Homo sapiens KIAA1758 protein protein.     61   3e-08
DQ309791-1|ABC48694.1|  871|Homo sapiens SamCystin protein.            60   3e-08
BC045621-1|AAH45621.1|  198|Homo sapiens ANKRD42 protein protein.      60   3e-08
AL807776-3|CAM13062.1|  871|Homo sapiens ankyrin repeat and ster...    60   3e-08
AL353782-4|CAM14169.1|  871|Homo sapiens ankyrin repeat and ster...    60   3e-08
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein.    60   3e-08
AF163302-1|AAD45121.1| 2161|Homo sapiens somatostatin receptor i...    60   5e-08
BC001244-1|AAH01244.1|  252|Homo sapiens ASB9 protein protein.         60   6e-08
AK092564-1|BAC03915.1|  263|Homo sapiens protein ( Homo sapiens ...    60   6e-08
BC014558-1|AAH14558.1|  627|Homo sapiens fem-1 homolog b (C. ele...    59   8e-08
BC010122-1|AAH10122.1|  627|Homo sapiens fem-1 homolog b (C. ele...    59   8e-08
AF392450-1|AAL40663.1|  950|Homo sapiens oxysterol-binding prote...    59   8e-08
AF323726-1|AAG53407.2|  927|Homo sapiens OSBP-related protein 1 ...    59   8e-08
AF204883-1|AAF69303.1|  627|Homo sapiens FEM1 beta protein.            59   8e-08
AF178632-1|AAF05314.1|  627|Homo sapiens FEM-1-like death recept...    59   8e-08
AB007856-1|BAA23692.2|  627|Homo sapiens KIAA0396 protein.             59   8e-08
DQ224339-1|ABB02425.1|  618|Homo sapiens Ikappa B-zeta variant 3...    59   1e-07
BC060800-1|AAH60800.1|  718|Homo sapiens nuclear factor of kappa...    59   1e-07
BC024189-1|AAH24189.2|  345|Homo sapiens fibronectin type III an...    59   1e-07
AY358154-1|AAQ88521.1|  371|Homo sapiens CG3104 hlg protein.           59   1e-07
AF548362-1|AAN40698.1|  618|Homo sapiens MAIL-S protein.               59   1e-07
AF121775-1|AAF24125.1|  366|Homo sapiens nasopharyngeal carcinom...    59   1e-07
AB037925-1|BAB40337.1|  718|Homo sapiens MAIL protein.                 59   1e-07
U76638-1|AAB38316.1|  777|Homo sapiens BRCA1-associated RING dom...    58   1e-07
BC126426-1|AAI26427.1|  777|Homo sapiens BRCA1 associated RING d...    58   1e-07
BC039715-1|AAH39715.1|  161|Homo sapiens ANKRD10 protein protein.      58   1e-07
BC022878-1|AAH22878.1|  776|Homo sapiens ankyrin repeat domain 5...    58   1e-07
AL109754-1|CAB87618.2|  776|Homo sapiens ankyrin repeat domain 5...    58   1e-07
AK223409-1|BAD97129.1|  777|Homo sapiens BRCA1 associated RING d...    58   1e-07
AK025322-1|BAB15111.1|  416|Homo sapiens protein ( Homo sapiens ...    58   1e-07
AF308292-1|AAG48260.1|  352|Homo sapiens serologically defined b...    58   1e-07
AF038042-1|AAB99978.1|  777|Homo sapiens BRCA1-associated RING d...    58   1e-07
AC016708-1|AAX93130.1|  777|Homo sapiens unknown protein.              58   1e-07
U17074-1|AAC50074.1|  168|Homo sapiens p18 protein.                    58   2e-07
CR450289-1|CAG29285.1|  168|Homo sapiens CDKN2C protein.               58   2e-07
BX537857-1|CAD97864.1|  306|Homo sapiens hypothetical protein pr...    58   2e-07
BC126428-1|AAI26429.1|  777|Homo sapiens BRCA1 associated RING d...    58   2e-07
BC031303-1|AAH31303.1|  183|Homo sapiens ankyrin repeat domain 3...    58   2e-07
BC005041-1|AAH05041.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
BC000598-1|AAH00598.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AY094608-1|AAM11873.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AL590455-1|CAH71955.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AL359977-3|CAH70191.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AF041250-1|AAC39783.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AF041248-1|AAC39782.1|  168|Homo sapiens cyclin-dependent kinase...    58   2e-07
AC092636-4|AAY14966.1|  183|Homo sapiens unknown protein.              58   2e-07
AB209367-1|BAD92604.1|  192|Homo sapiens hypothetical protein MG...    58   2e-07
U13048-1|AAA65710.1|  348|Homo sapiens nuclear respiratory facto...    58   2e-07
U13047-1|AAA65709.1|  360|Homo sapiens nuclear respiratory facto...    58   2e-07
U13046-1|AAA65708.1|  383|Homo sapiens nuclear respiratory facto...    58   2e-07

>Y10601-1|CAA71610.1| 1119|Homo sapiens ankyrin-like protein
           protein.
          Length = 1119

 Score =  400 bits (984), Expect = e-110
 Identities = 221/631 (35%), Positives = 355/631 (56%), Gaps = 20/631 (3%)

Query: 52  HQASARNNTNILHFINNYAG--DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           H A+A     ++  I   +    L+  D+ GNTPLH AVE   ++++++LL +    ++ 
Sbjct: 68  HYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR 127

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
           N    AP+H+A +     V++V  +++++ +VN  GE+G TA+  A   ++    +IL+ 
Sbjct: 128 NFNMMAPLHIAVQGMNNEVMKVLLEHRTI-DVNLEGENGNTAVIIACTTNNSEALQILLN 186

Query: 170 DLDAEWKKPCNN---GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
               +  KPC +   G +PIH+AA + S   +E+ L++GE+ G +R+  I+  +N    P
Sbjct: 187 ----KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATP 242

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH AV  GD++ +++CL +GA+I   +    T +H A  QGA +IVKLM +         
Sbjct: 243 LHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIV 302

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
            T+ D    T +H A++FDH E+ +YLI+ G+DIN +D E RSPL+LA + A W  V+ L
Sbjct: 303 NTT-DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +  GA + +KD   RN LHL V     L++          + + +L+ ++DN GC+PLHY
Sbjct: 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQM--QQIKELVMDEDNDGCTPLHY 419

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A R+G   S+ NL+     I+ K+ + +SPLHFAA YGR +T  +LL     T ++NE D
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSH 526
             G+TPLH+A++ GH +VV LLL +GAL   DHNG   LH A+M GYT+T++++   +  
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK 539

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAM 586
             D++D+DGNT+LH A  E    ++ALLLS    +  N    S +  A++ K  E  L +
Sbjct: 540 CTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTI 599

Query: 587 VTHEQRAKEVMALRSDRHP---CVTLALIAYMPRVFEAVQDKCITKANCKKDSKSFYIKY 643
           +   +R  E + + S   P   C    +I Y+P   + + D C+  +   K  + +YI+Y
Sbjct: 600 I-RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEY 658

Query: 644 SFEAL-CPQLMDEDGTRKSQQAQQIPLPALN 673
           +F+ L CP  ++      +Q     PL ALN
Sbjct: 659 NFKYLQCP--LEFTKKTPTQDVIYEPLTALN 687



 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 128/573 (22%), Positives = 234/573 (40%), Gaps = 52/573 (9%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYL-SEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           L T   ++  F   AA  G ++   ++   S    L   D  G T  H A  +N    + 
Sbjct: 56  LKTCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVK 115

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH-VETSVLNEKCQAPIHMATEL 123
           F+ +   + N ++     PLH+AV+    + ++ LL+   ++ ++  E     + +A   
Sbjct: 116 FLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTT 175

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKP----- 178
           N    LQ+     +     +  + G   +H AA      C +I++   +           
Sbjct: 176 NNSEALQILLNKGA--KPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHIN 233

Query: 179 -CNNG-YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
             NNG   P+H A +N     I++ L  G Q        I   +      +H A   G  
Sbjct: 234 FMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ--------IDPVEKGRCTAIHFAATQGAT 285

Query: 237 KAVELCLRSGAK----ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           + V+L + S +     ++T      T +H A      ++   + ++      A +   D 
Sbjct: 286 EIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISV-----GADINKIDS 340

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVH----TLI 347
           +  +P+  A       IVN L+++G+ ++  D   R+ L L   +  G + +      + 
Sbjct: 341 EGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQ 400

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYA 407
           ++   +  +D +    LH     GG       S  +    ++   ++ K     SPLH+A
Sbjct: 401 QIKELVMDEDNDGCTPLHYACRQGG-----PGSVNNLLGFNV--SIHSKSKDKKSPLHFA 453

Query: 408 SREGHIRSLENLIRLGACINLKNN---NNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           +  G I + + L++  +   L N    +  +PLH AA+ G  H     L   KG   +  
Sbjct: 454 ASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNG--HDKVVQLLLKKGALFL-- 509

Query: 465 SDGEGLTPLHIASREGHTRVVHLLL--NRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS 522
           SD  G T LH AS  G+T+ + ++L  N       D +G   LH AA  G+ K + LL S
Sbjct: 510 SDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
            ++ ++  ++K   + LHLA + NK   + L +
Sbjct: 570 HNADIV--LNKQQASFLHLA-LHNKRKEVVLTI 599



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 72/308 (23%), Positives = 128/308 (41%), Gaps = 15/308 (4%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           DG   T  H+AS  ++  +  ++ +   D+N  D+ G +PL +A  + + + +  LL + 
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 104 VETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKSLFN-VNQGGEHGRTALHFAAIHDH 160
            +  + +   +  +H+  +      ++   F + + +   V      G T LH+A     
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425

Query: 161 DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYD 220
                 L+   +        +   P+H AA      T +  LQ       +  ++++  D
Sbjct: 426 PGSVNNLL-GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ-----DISDTRLLNEGD 479

Query: 221 NEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
             G  PLH A   G  K V+L L+ GA +    H+  T +H A   G    +K++     
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNL 538

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGW 340
           K    C    D    T +H AA   H + V  L++  +DI  L+K++ S L LA      
Sbjct: 539 K----CTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRK 593

Query: 341 RTVHTLIR 348
             V T+IR
Sbjct: 594 EVVLTIIR 601



 Score = 35.9 bits (79), Expect = 0.85
 Identities = 35/165 (21%), Positives = 70/165 (42%), Gaps = 8/165 (4%)

Query: 404 LHYASREGHIRSLENLIRLGA--CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           LHYA+ EG I  +E + R  +   ++  ++   +PLH A    +  +   LL        
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANP-- 124

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
            N  +   + PLHIA +  +  V+ +LL    +       NG   + +A  +  ++ +++
Sbjct: 125 -NLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQI 183

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           L +  +    + +K G   +H A        + ++L  G    Y+
Sbjct: 184 LLNKGAKPC-KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYS 227


>U50133-1|AAB47805.1| 1856|Homo sapiens ankyrin protein.
          Length = 1856

 Score =  190 bits (462), Expect = 3e-47
 Identities = 156/542 (28%), Positives = 251/542 (46%), Gaps = 37/542 (6%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F++AA SGN+D  +  +L     +   + +G TA H A+      ++  + NY  ++NA+
Sbjct: 16  FLRAARSGNLDKALD-HLRNGVDINTCNQKGNTALHIAALAGQDEVVRELVNYGANVNAQ 74

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G TPL++A +   L+ +++LL+     +V  E    P+ +A +    +V+       
Sbjct: 75  SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV------A 128

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            L N    G+    ALH AA +D    A +L+ + D         G+ P+H AA   +  
Sbjct: 129 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLN 187

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
             ++ L     RG +    ++     G  PLH A   G++  V L L  GA+I T+  D 
Sbjct: 188 VAQLLL----NRGAS----VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 239

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
            TP+H A   G + I +++      +  A + +     ++PIH AA  DH + V  L+  
Sbjct: 240 LTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 294

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV-MNGGRLE 375
            ++I+ +  +  +PL +AA     R    L+  GA    + +N    LH+    N  R+ 
Sbjct: 295 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 354

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
           +           + +  + E   +G +PLH AS  GH+  ++NL++ GA  N+ N   E+
Sbjct: 355 ELLLK-----TGASIDAVTE---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 406

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
           PLH AAR G    A  LL +      +N    +  TPLH A+R GHT +V LLL   A  
Sbjct: 407 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 463

Query: 496 H-RDHNGRNPLHLAAMSGYTKTI-ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
           +     G  PLH+AA  G+ +T+  LL    S     + K G T LH+A    K     L
Sbjct: 464 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAEL 521

Query: 554 LL 555
           LL
Sbjct: 522 LL 523



 Score =  162 bits (393), Expect = 8e-39
 Identities = 139/527 (26%), Positives = 221/527 (41%), Gaps = 30/527 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L+  + +      G T  H AS R N  ++  + +    +  K     TPLH A  N
Sbjct: 190 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 249

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             +   E LL          +   +PIHMA + + +  +++  +Y +   ++       T
Sbjct: 250 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 307

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   H   AK+L+ D  A+      NG+ P+H A K    R +E+ L+ G     
Sbjct: 308 PLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--- 363

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                I      G  PLH A   G +  V+  L+ GA  +     + TP+H+A   G  +
Sbjct: 364 -----IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 418

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           + K  + +Q K K       D    TP+HCAA   H  +V  L+   ++ N       +P
Sbjct: 419 VAK--YLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 473

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSL 389
           L +AA      TV  L+   A            LH+    G  R+ +       H     
Sbjct: 474 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---- 529

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
               N     G +PLH A    ++  ++ L+  G   +    N  +PLH AA+  +   A
Sbjct: 530 ----NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 585

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL         N    +G+TPLH+A++EGH  +V LLL++ A  +  + +G  PLHL 
Sbjct: 586 RSLLQYGGSA---NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 642

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A  G+    ++L   H  ++D   + G T LH+A+       +  LL
Sbjct: 643 AQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 688



 Score =  160 bits (388), Expect = 3e-38
 Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 28/508 (5%)

Query: 50  AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           A H A+  ++T     +     + +     G TPLH+A   E L+  + LL +    +  
Sbjct: 143 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 202

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
            +    P+H+A+    V ++++     +        E   T LH AA + H   ++IL+ 
Sbjct: 203 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILL- 259

Query: 170 DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHS 229
           D  A  +    NG  PIH AA+      + + LQ+  +        I     +   PLH 
Sbjct: 260 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE--------IDDITLDHLTPLHV 311

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A H G  +  ++ L  GAK +++  +  TP+H+AC +  + +++L+      +  A + +
Sbjct: 312 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDA 366

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
                +TP+H A+   H  IV  L+  G+  N  + +  +PL +AA          L++ 
Sbjct: 367 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 426

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
            A +  K  + +  LH     G          +++   +L          G +PLH A+R
Sbjct: 427 KAKVNAKAKDDQTPLHCAARIG-HTNMVKLLLENNANPNLAT------TAGHTPLHIAAR 479

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           EGH+ ++  L+   A          +PLH AA+YG+   A  LL+ D      N +   G
Sbjct: 480 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNG 536

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           LTPLH+A    +  +V LLL RG   H    NG  PLH+AA     +    L   +    
Sbjct: 537 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSA 595

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLS 556
           +     G T LHLA  E     +ALLLS
Sbjct: 596 NAESVQGVTPLHLAAQEGHAEMVALLLS 623



 Score =  144 bits (349), Expect = 2e-33
 Identities = 125/442 (28%), Positives = 191/442 (43%), Gaps = 26/442 (5%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N+  ++  +      ++A   +G TPLHVA     L  ++ LLQ+    
Sbjct: 338 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 397

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +V N K + P+HMA       V +   + K+   VN   +  +T LH AA   H    K+
Sbjct: 398 NVSNVKVETPLHMAARAGHTEVAKYLLQNKA--KVNAKAKDDQTPLHCAARIGHTNMVKL 455

Query: 167 LITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           L+ + +A        G+ P+H AA+     T+   L+    + C  +        +G  P
Sbjct: 456 LLEN-NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK--------KGFTP 506

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A   G ++  EL L   A  +    +  TP+H+A     LDIVKL+   +    H  
Sbjct: 507 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPH-- 563

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
             S      TP+H AA  +  E+   L+  G   N    +  +PL LAA       V  L
Sbjct: 564 --SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 621

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +   A+  L + +    LHLV   G           D   K  + +++     G +PLH 
Sbjct: 622 LSKQANGNLGNKSGLTPLHLVAQEG------HVPVADVLIKHGV-MVDATTRMGYTPLHV 674

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           AS  G+I+ ++ L++  A +N K     SPLH AA+ G       LL +       NE  
Sbjct: 675 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVS 731

Query: 467 GEGLTPLHIASREGHTRVVHLL 488
            +G TPL IA R G+  V  +L
Sbjct: 732 SDGTTPLAIAKRLGYISVTDVL 753



 Score =  139 bits (336), Expect = 6e-32
 Identities = 124/519 (23%), Positives = 218/519 (42%), Gaps = 28/519 (5%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF 65
           +   TK  LS    AA+  ++D  +RL L   + +        T  H A+   +  +   
Sbjct: 265 IQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 323

Query: 66  INNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNK 125
           + +     N++   G TPLH+A +   +  +E LL+       + E    P+H+A+ +  
Sbjct: 324 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 383

Query: 126 VSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYP 185
           + +++   +  +  NV+       T LH AA   H   AK L+ +  A+      +   P
Sbjct: 384 LPIVKNLLQRGASPNVSN--VKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTP 440

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +H AA+   +  +++ L+             +L    G+ PLH A   G ++ V   L  
Sbjct: 441 LHCAARIGHTNMVKLLLE--------NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 492

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFD 305
            A  +       TP+H+A   G + + +L+      E+ A   +     +TP+H A   +
Sbjct: 493 EASQACMTKKGFTPLHVAAKYGKVRVAELLL-----ERDAHPNAAGKNGLTPLHVAVHHN 547

Query: 306 HPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           + +IV  L+  G   +       +PL +AA +       +L++ G     + +     LH
Sbjct: 548 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 607

Query: 366 LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGAC 425
           L    G   E  A         +L       + +G +PLH  ++EGH+   + LI+ G  
Sbjct: 608 LAAQEG-HAEMVALLLSKQANGNL------GNKSGLTPLHLVAQEGHVPVADVLIKHGVM 660

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++       +PLH A+ YG       LL        +N     G +PLH A+++GHT +V
Sbjct: 661 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 717

Query: 486 HLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            LLL  GA  +    +G  PL +A   GY    ++L  V
Sbjct: 718 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 756



 Score = 96.7 bits (230), Expect = 4e-19
 Identities = 100/369 (27%), Positives = 163/369 (44%), Gaps = 55/369 (14%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L +A  G   KA++  LR+G  I+T     +T +H+A   G  ++V+ +        +  
Sbjct: 17  LRAARSGNLDKALDH-LRNGVDINTCNQKGNTALHIAALAGQDEVVRELVN------YGA 69

Query: 287 LTSCDVQK-MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
             +   QK  TP++ AA  +H E+V +L+  G++ N   ++  +PL +A  +     V  
Sbjct: 70  NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 129

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           LI  G   +++       LH+   N       A   ++     +L        TG +PLH
Sbjct: 130 LINYGTKGKVR----LPALHIAARNDDT-RTAAVLLQNDPNPDVLS------KTGFTPLH 178

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
            A+   ++   + L+  GA +N    N  +PLH A+R G       LLD  +G  I  ++
Sbjct: 179 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD--RGAQIETKT 236

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL---- 520
             E LTPLH A+R GH R+  +LL+ GA +  +  NG +P+H+AA   +   + LL    
Sbjct: 237 KDE-LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 295

Query: 521 ----------------------HSVHSHLLDQIDK------DGNTSLHLATMENKPSSIA 552
                                 H V   LLD+  K      +G T LH+A  +N    + 
Sbjct: 296 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 355

Query: 553 LLLSMGCRL 561
           LLL  G  +
Sbjct: 356 LLLKTGASI 364



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 53/183 (28%), Positives = 85/183 (46%), Gaps = 13/183 (7%)

Query: 383 DHCEKSL-LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAA 441
           DH    + +   N+K NT    LH A+  G    +  L+  GA +N ++    +PL+ AA
Sbjct: 30  DHLRNGVDINTCNQKGNTA---LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 86

Query: 442 RYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNG 501
           +         LL++     +  E   +G TPL +A ++GH  VV  L+N G         
Sbjct: 87  QENHLEVVKFLLENGANQNVATE---DGFTPLAVALQQGHENVVAHLINYGT----KGKV 139

Query: 502 RNP-LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
           R P LH+AA +  T+T  +L     +  D + K G T LH+A      +   LLL+ G  
Sbjct: 140 RLPALHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 198

Query: 561 LSY 563
           +++
Sbjct: 199 VNF 201



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 46/176 (26%), Positives = 77/176 (43%), Gaps = 9/176 (5%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N +   G +PL+ A++E H+  ++ L+  GA  N+   +  +PL  A + G  +    L
Sbjct: 71  VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 130

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           ++   GT          L  LHIA+R   TR   +LL            G  PLH+AA  
Sbjct: 131 INY--GT-----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 183

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
                 +LL +     ++   ++G T LH+A+       + LLL  G ++     D
Sbjct: 184 ENLNVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 238


>X16609-2|CAA34611.1| 1719|Homo sapiens alt. ankyrin (variant 2.2)
           protein.
          Length = 1719

 Score =  184 bits (449), Expect = 1e-45
 Identities = 156/555 (28%), Positives = 254/555 (45%), Gaps = 37/555 (6%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           + ++T  +  L+    A++ G+V   + L L +   L     +G TA H A+      ++
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVEL-LHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + NY  ++NA+   G TPL++A +   L+ +++LL+     +V  E    P+ +A + 
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY 183
              +V+        L N    G+    ALH AA +D    A +L+ + D         G+
Sbjct: 155 GHENVV------AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGF 207

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H AA   +    ++ L     RG +    ++     G  PLH A   G++  V L L
Sbjct: 208 TPLHIAAHYENLNVAQLLL----NRGAS----VNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             GA+I T+  D  TP+H A   G + I +++      +  A + +     ++PIH AA 
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQ 314

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
            DH + V  L+   ++I+ +  +  +PL +AA     R    L+  GA    + +N    
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 364 LHLVV-MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRL 422
           LH+    N  R+ +           + +  + E   +G +PLH AS  GH+  ++NL++ 
Sbjct: 375 LHIACKKNHVRVMELLLK-----TGASIDAVTE---SGLTPLHVASFMGHLPIVKNLLQR 426

Query: 423 GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           GA  N+ N   E+PLH AAR G    A  LL +      +N    +  TPLH A+R GHT
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHT 483

Query: 483 RVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI-ELLHSVHSHLLDQIDKDGNTSLH 540
            +V LLL   A  +     G  PLH+AA  G+ +T+  LL    S     + K G T LH
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLH 541

Query: 541 LATMENKPSSIALLL 555
           +A    K     LLL
Sbjct: 542 VAAKYGKVRVAELLL 556



 Score =  162 bits (393), Expect = 8e-39
 Identities = 139/527 (26%), Positives = 221/527 (41%), Gaps = 30/527 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L+  + +      G T  H AS R N  ++  + +    +  K     TPLH A  N
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             +   E LL          +   +PIHMA + + +  +++  +Y +   ++       T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 340

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   H   AK+L+ D  A+      NG+ P+H A K    R +E+ L+ G     
Sbjct: 341 PLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--- 396

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                I      G  PLH A   G +  V+  L+ GA  +     + TP+H+A   G  +
Sbjct: 397 -----IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           + K  + +Q K K       D    TP+HCAA   H  +V  L+   ++ N       +P
Sbjct: 452 VAK--YLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSL 389
           L +AA      TV  L+   A            LH+    G  R+ +       H     
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---- 562

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
               N     G +PLH A    ++  ++ L+  G   +    N  +PLH AA+  +   A
Sbjct: 563 ----NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL         N    +G+TPLH+A++EGH  +V LLL++ A  +  + +G  PLHL 
Sbjct: 619 RSLLQYGGSA---NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A  G+    ++L   H  ++D   + G T LH+A+       +  LL
Sbjct: 676 AQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721



 Score =  160 bits (388), Expect = 3e-38
 Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 28/508 (5%)

Query: 50  AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           A H A+  ++T     +     + +     G TPLH+A   E L+  + LL +    +  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
            +    P+H+A+    V ++++     +        E   T LH AA + H   ++IL+ 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILL- 292

Query: 170 DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHS 229
           D  A  +    NG  PIH AA+      + + LQ+  +        I     +   PLH 
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE--------IDDITLDHLTPLHV 344

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A H G  +  ++ L  GAK +++  +  TP+H+AC +  + +++L+      +  A + +
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDA 399

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
                +TP+H A+   H  IV  L+  G+  N  + +  +PL +AA          L++ 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
            A +  K  + +  LH     G          +++   +L          G +PLH A+R
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIG-HTNMVKLLLENNANPNLAT------TAGHTPLHIAAR 512

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           EGH+ ++  L+   A          +PLH AA+YG+   A  LL+ D      N +   G
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNG 569

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           LTPLH+A    +  +V LLL RG   H    NG  PLH+AA     +    L   +    
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSA 628

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLS 556
           +     G T LHLA  E     +ALLLS
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLS 656



 Score =  144 bits (349), Expect = 2e-33
 Identities = 125/442 (28%), Positives = 191/442 (43%), Gaps = 26/442 (5%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N+  ++  +      ++A   +G TPLHVA     L  ++ LLQ+    
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +V N K + P+HMA       V +   + K+   VN   +  +T LH AA   H    K+
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKA--KVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 LITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           L+ + +A        G+ P+H AA+     T+   L+    + C  +        +G  P
Sbjct: 489 LLEN-NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK--------KGFTP 539

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A   G ++  EL L   A  +    +  TP+H+A     LDIVKL+   +    H  
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPH-- 596

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
             S      TP+H AA  +  E+   L+  G   N    +  +PL LAA       V  L
Sbjct: 597 --SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +   A+  L + +    LHLV   G           D   K  + +++     G +PLH 
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEG------HVPVADVLIKHGV-MVDATTRMGYTPLHV 707

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           AS  G+I+ ++ L++  A +N K     SPLH AA+ G       LL +       NE  
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVS 764

Query: 467 GEGLTPLHIASREGHTRVVHLL 488
            +G TPL IA R G+  V  +L
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVL 786



 Score =  139 bits (336), Expect = 6e-32
 Identities = 124/519 (23%), Positives = 218/519 (42%), Gaps = 28/519 (5%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF 65
           +   TK  LS    AA+  ++D  +RL L   + +        T  H A+   +  +   
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 66  INNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNK 125
           + +     N++   G TPLH+A +   +  +E LL+       + E    P+H+A+ +  
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 126 VSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYP 185
           + +++   +  +  NV+       T LH AA   H   AK L+ +  A+      +   P
Sbjct: 417 LPIVKNLLQRGASPNVSN--VKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTP 473

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +H AA+   +  +++ L+             +L    G+ PLH A   G ++ V   L  
Sbjct: 474 LHCAARIGHTNMVKLLLE--------NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFD 305
            A  +       TP+H+A   G + + +L+      E+ A   +     +TP+H A   +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLL-----ERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 306 HPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           + +IV  L+  G   +       +PL +AA +       +L++ G     + +     LH
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 366 LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGAC 425
           L    G   E  A         +L       + +G +PLH  ++EGH+   + LI+ G  
Sbjct: 641 LAAQEG-HAEMVALLLSKQANGNL------GNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++       +PLH A+ YG       LL        +N     G +PLH A+++GHT +V
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 486 HLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            LLL  GA  +    +G  PL +A   GY    ++L  V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789



 Score =  115 bits (276), Expect = 1e-24
 Identities = 115/446 (25%), Positives = 191/446 (42%), Gaps = 36/446 (8%)

Query: 100 LQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD 159
           L+  V+ +  N+     +H+A++   V ++ V   +K +  +    + G TALH AA+  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMV-VELLHKEII-LETTTKKGNTALHIAALAG 89

Query: 160 HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
            D   + L+ +  A        G+ P++ AA+      ++  L+ G  +    E      
Sbjct: 90  QDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE------ 142

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
             +G  PL  A+  G    V   +  G K   +   L    H+A          ++    
Sbjct: 143 --DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL----HIAARNDDTRTAAVLLQND 196

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
           P       T       TP+H AA +++  +   L+N G+ +N   +   +PL +A+ R  
Sbjct: 197 PNPDVLSKTG-----FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQLLNEKDN 398
              V  L+  GA I+ K  +    LH    NG  R+ +      DH        +  K  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL---DHGAP-----IQAKTK 303

Query: 399 TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
            G SP+H A++  H+  +  L++  A I+    ++ +PLH AA  G    A  LL  DKG
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL--DKG 361

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTI 517
               N     G TPLHIA ++ H RV+ LLL  GA +     +G  PLH+A+  G+   +
Sbjct: 362 A-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 518 E-LLHSVHSHLLDQIDKDGNTSLHLA 542
           + LL    S  +  +  +  T LH+A
Sbjct: 421 KNLLQRGASPNVSNVKVE--TPLHMA 444



 Score =  110 bits (265), Expect = 2e-23
 Identities = 101/357 (28%), Positives = 164/357 (45%), Gaps = 33/357 (9%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L +A  G   KA++  LR+G  I+T   +    +HLA  +G    VK++  +  KE    
Sbjct: 17  LRAARSGNLDKALDH-LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKE--II 70

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           L +   +  T +H AA+    E+V  L+N G+++N   ++  +PL +AA       V  L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 347 IRLGAD-------------IQLKDINSRNVLHLV---VMNGGRLEDFAASCKDHCEKSLL 390
           +  GA+             + L+  +   V HL+        RL     + ++   ++  
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 391 QLLNEKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
            LL    N      TG +PLH A+   ++   + L+  GA +N    N  +PLH A+R G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRN 503
                  LL  D+G  I  ++  E LTPLH A+R GH R+  +LL+ GA +  +  NG +
Sbjct: 251 NVIMVRLLL--DRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
           P+H+AA   +   + LL    +  +D I  D  T LH+A          +LL  G +
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAE-IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 102/387 (26%), Positives = 161/387 (41%), Gaps = 34/387 (8%)

Query: 179 CN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK 237
           CN NG   +H A+K    + +   L         +E ++     +GN  LH A   G  +
Sbjct: 41  CNQNGLNGLHLASKEGHVKMVVELLH--------KEIILETTTKKGNTALHIAALAGQDE 92

Query: 238 AVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTP 297
            V   +  GA ++ Q     TP+++A  +  L++VK +      E  A          TP
Sbjct: 93  VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL-----ENGANQNVATEDGFTP 147

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +  A    H  +V +LIN G+      K R   L +AA     RT   L++   +  +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
                 LH+        E+   +       +    +N     G +PLH ASR G++  + 
Sbjct: 204 KTGFTPLHIAA----HYENLNVA---QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
            L+  GA I  K  +  +PLH AAR G    +  LLD       I      GL+P+H+A+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIHMAA 313

Query: 478 REGHTRVVHLLLNRGALLHR---DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
           +  H   V LLL   A +     DH    PLH+AA  G+ +  ++L    +    +   +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370

Query: 535 GNTSLHLATMENKPSSIALLLSMGCRL 561
           G T LH+A  +N    + LLL  G  +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASI 397



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 62/218 (28%), Positives = 97/218 (44%), Gaps = 16/218 (7%)

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +R G DI   + N  N LHL    G          K+     +L+   +K NT    LH 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE----IILETTTKKGNTA---LHI 84

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+  G    +  L+  GA +N ++    +PL+ AA+         LL++     +  E  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE-- 142

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNP-LHLAAMSGYTKTIELLHSVHS 525
            +G TPL +A ++GH  VV  L+N G         R P LH+AA +  T+T  +L     
Sbjct: 143 -DGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 526 HLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY 563
           +  D + K G T LH+A      +   LLL+ G  +++
Sbjct: 198 NP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 60/258 (23%), Positives = 105/258 (40%), Gaps = 22/258 (8%)

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  G DIN  ++   + L LA+     + V  L+     ++         LH+  + G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG-- 89

Query: 374 LEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
                   +D   + L+     +N +   G +PL+ A++E H+  ++ L+  GA  N+  
Sbjct: 90  --------QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +PL  A + G  +    L++   GT          L  LHIA+R   TR   +LL 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINY--GT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                      G  PLH+AA        +LL +     ++   ++G T LH+A+      
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVI 253

Query: 550 SIALLLSMGCRLSYNNMD 567
            + LLL  G ++     D
Sbjct: 254 MVRLLLDRGAQIETKTKD 271


>X16609-1|CAA34610.1| 1881|Homo sapiens protein ( Human mRNA for
           ankyrin (variant 2.1). ).
          Length = 1881

 Score =  184 bits (449), Expect = 1e-45
 Identities = 156/555 (28%), Positives = 254/555 (45%), Gaps = 37/555 (6%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           + ++T  +  L+    A++ G+V   + L L +   L     +G TA H A+      ++
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVEL-LHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + NY  ++NA+   G TPL++A +   L+ +++LL+     +V  E    P+ +A + 
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY 183
              +V+        L N    G+    ALH AA +D    A +L+ + D         G+
Sbjct: 155 GHENVV------AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGF 207

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H AA   +    ++ L     RG +    ++     G  PLH A   G++  V L L
Sbjct: 208 TPLHIAAHYENLNVAQLLL----NRGAS----VNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             GA+I T+  D  TP+H A   G + I +++      +  A + +     ++PIH AA 
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQ 314

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
            DH + V  L+   ++I+ +  +  +PL +AA     R    L+  GA    + +N    
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 364 LHLVV-MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRL 422
           LH+    N  R+ +           + +  + E   +G +PLH AS  GH+  ++NL++ 
Sbjct: 375 LHIACKKNHVRVMELLLK-----TGASIDAVTE---SGLTPLHVASFMGHLPIVKNLLQR 426

Query: 423 GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           GA  N+ N   E+PLH AAR G    A  LL +      +N    +  TPLH A+R GHT
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHT 483

Query: 483 RVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI-ELLHSVHSHLLDQIDKDGNTSLH 540
            +V LLL   A  +     G  PLH+AA  G+ +T+  LL    S     + K G T LH
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLH 541

Query: 541 LATMENKPSSIALLL 555
           +A    K     LLL
Sbjct: 542 VAAKYGKVRVAELLL 556



 Score =  162 bits (393), Expect = 8e-39
 Identities = 139/527 (26%), Positives = 221/527 (41%), Gaps = 30/527 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L+  + +      G T  H AS R N  ++  + +    +  K     TPLH A  N
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             +   E LL          +   +PIHMA + + +  +++  +Y +   ++       T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 340

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   H   AK+L+ D  A+      NG+ P+H A K    R +E+ L+ G     
Sbjct: 341 PLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--- 396

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                I      G  PLH A   G +  V+  L+ GA  +     + TP+H+A   G  +
Sbjct: 397 -----IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           + K  + +Q K K       D    TP+HCAA   H  +V  L+   ++ N       +P
Sbjct: 452 VAK--YLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSL 389
           L +AA      TV  L+   A            LH+    G  R+ +       H     
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---- 562

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
               N     G +PLH A    ++  ++ L+  G   +    N  +PLH AA+  +   A
Sbjct: 563 ----NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL         N    +G+TPLH+A++EGH  +V LLL++ A  +  + +G  PLHL 
Sbjct: 619 RSLLQYGGSA---NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A  G+    ++L   H  ++D   + G T LH+A+       +  LL
Sbjct: 676 AQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721



 Score =  160 bits (388), Expect = 3e-38
 Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 28/508 (5%)

Query: 50  AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           A H A+  ++T     +     + +     G TPLH+A   E L+  + LL +    +  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
            +    P+H+A+    V ++++     +        E   T LH AA + H   ++IL+ 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILL- 292

Query: 170 DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHS 229
           D  A  +    NG  PIH AA+      + + LQ+  +        I     +   PLH 
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE--------IDDITLDHLTPLHV 344

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A H G  +  ++ L  GAK +++  +  TP+H+AC +  + +++L+      +  A + +
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDA 399

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
                +TP+H A+   H  IV  L+  G+  N  + +  +PL +AA          L++ 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
            A +  K  + +  LH     G          +++   +L          G +PLH A+R
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIG-HTNMVKLLLENNANPNLAT------TAGHTPLHIAAR 512

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           EGH+ ++  L+   A          +PLH AA+YG+   A  LL+ D      N +   G
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNG 569

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           LTPLH+A    +  +V LLL RG   H    NG  PLH+AA     +    L   +    
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSA 628

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLS 556
           +     G T LHLA  E     +ALLLS
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLS 656



 Score =  144 bits (349), Expect = 2e-33
 Identities = 125/442 (28%), Positives = 191/442 (43%), Gaps = 26/442 (5%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N+  ++  +      ++A   +G TPLHVA     L  ++ LLQ+    
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +V N K + P+HMA       V +   + K+   VN   +  +T LH AA   H    K+
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKA--KVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 LITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           L+ + +A        G+ P+H AA+     T+   L+    + C  +        +G  P
Sbjct: 489 LLEN-NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK--------KGFTP 539

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A   G ++  EL L   A  +    +  TP+H+A     LDIVKL+   +    H  
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPH-- 596

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
             S      TP+H AA  +  E+   L+  G   N    +  +PL LAA       V  L
Sbjct: 597 --SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +   A+  L + +    LHLV   G           D   K  + +++     G +PLH 
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEG------HVPVADVLIKHGV-MVDATTRMGYTPLHV 707

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           AS  G+I+ ++ L++  A +N K     SPLH AA+ G       LL +       NE  
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVS 764

Query: 467 GEGLTPLHIASREGHTRVVHLL 488
            +G TPL IA R G+  V  +L
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVL 786



 Score =  139 bits (336), Expect = 6e-32
 Identities = 124/519 (23%), Positives = 218/519 (42%), Gaps = 28/519 (5%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF 65
           +   TK  LS    AA+  ++D  +RL L   + +        T  H A+   +  +   
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 66  INNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNK 125
           + +     N++   G TPLH+A +   +  +E LL+       + E    P+H+A+ +  
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 126 VSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYP 185
           + +++   +  +  NV+       T LH AA   H   AK L+ +  A+      +   P
Sbjct: 417 LPIVKNLLQRGASPNVSN--VKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTP 473

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +H AA+   +  +++ L+             +L    G+ PLH A   G ++ V   L  
Sbjct: 474 LHCAARIGHTNMVKLLLE--------NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFD 305
            A  +       TP+H+A   G + + +L+      E+ A   +     +TP+H A   +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLL-----ERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 306 HPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           + +IV  L+  G   +       +PL +AA +       +L++ G     + +     LH
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 366 LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGAC 425
           L    G   E  A         +L       + +G +PLH  ++EGH+   + LI+ G  
Sbjct: 641 LAAQEG-HAEMVALLLSKQANGNL------GNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++       +PLH A+ YG       LL        +N     G +PLH A+++GHT +V
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 486 HLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            LLL  GA  +    +G  PL +A   GY    ++L  V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789



 Score =  115 bits (276), Expect = 1e-24
 Identities = 115/446 (25%), Positives = 191/446 (42%), Gaps = 36/446 (8%)

Query: 100 LQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD 159
           L+  V+ +  N+     +H+A++   V ++ V   +K +  +    + G TALH AA+  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMV-VELLHKEII-LETTTKKGNTALHIAALAG 89

Query: 160 HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
            D   + L+ +  A        G+ P++ AA+      ++  L+ G  +    E      
Sbjct: 90  QDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE------ 142

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
             +G  PL  A+  G    V   +  G K   +   L    H+A          ++    
Sbjct: 143 --DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL----HIAARNDDTRTAAVLLQND 196

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
           P       T       TP+H AA +++  +   L+N G+ +N   +   +PL +A+ R  
Sbjct: 197 PNPDVLSKTG-----FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQLLNEKDN 398
              V  L+  GA I+ K  +    LH    NG  R+ +      DH        +  K  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL---DHGAP-----IQAKTK 303

Query: 399 TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
            G SP+H A++  H+  +  L++  A I+    ++ +PLH AA  G    A  LL  DKG
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL--DKG 361

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTI 517
               N     G TPLHIA ++ H RV+ LLL  GA +     +G  PLH+A+  G+   +
Sbjct: 362 A-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 518 E-LLHSVHSHLLDQIDKDGNTSLHLA 542
           + LL    S  +  +  +  T LH+A
Sbjct: 421 KNLLQRGASPNVSNVKVE--TPLHMA 444



 Score =  110 bits (265), Expect = 2e-23
 Identities = 101/357 (28%), Positives = 164/357 (45%), Gaps = 33/357 (9%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L +A  G   KA++  LR+G  I+T   +    +HLA  +G    VK++  +  KE    
Sbjct: 17  LRAARSGNLDKALDH-LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKE--II 70

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           L +   +  T +H AA+    E+V  L+N G+++N   ++  +PL +AA       V  L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 347 IRLGAD-------------IQLKDINSRNVLHLV---VMNGGRLEDFAASCKDHCEKSLL 390
           +  GA+             + L+  +   V HL+        RL     + ++   ++  
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 391 QLLNEKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
            LL    N      TG +PLH A+   ++   + L+  GA +N    N  +PLH A+R G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRN 503
                  LL  D+G  I  ++  E LTPLH A+R GH R+  +LL+ GA +  +  NG +
Sbjct: 251 NVIMVRLLL--DRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
           P+H+AA   +   + LL    +  +D I  D  T LH+A          +LL  G +
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAE-IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 102/387 (26%), Positives = 161/387 (41%), Gaps = 34/387 (8%)

Query: 179 CN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK 237
           CN NG   +H A+K    + +   L         +E ++     +GN  LH A   G  +
Sbjct: 41  CNQNGLNGLHLASKEGHVKMVVELLH--------KEIILETTTKKGNTALHIAALAGQDE 92

Query: 238 AVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTP 297
            V   +  GA ++ Q     TP+++A  +  L++VK +      E  A          TP
Sbjct: 93  VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL-----ENGANQNVATEDGFTP 147

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +  A    H  +V +LIN G+      K R   L +AA     RT   L++   +  +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
                 LH+        E+   +       +    +N     G +PLH ASR G++  + 
Sbjct: 204 KTGFTPLHIAA----HYENLNVA---QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
            L+  GA I  K  +  +PLH AAR G    +  LLD       I      GL+P+H+A+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIHMAA 313

Query: 478 REGHTRVVHLLLNRGALLHR---DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
           +  H   V LLL   A +     DH    PLH+AA  G+ +  ++L    +    +   +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370

Query: 535 GNTSLHLATMENKPSSIALLLSMGCRL 561
           G T LH+A  +N    + LLL  G  +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASI 397



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 62/218 (28%), Positives = 97/218 (44%), Gaps = 16/218 (7%)

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +R G DI   + N  N LHL    G          K+     +L+   +K NT    LH 
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE----IILETTTKKGNTA---LHI 84

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+  G    +  L+  GA +N ++    +PL+ AA+         LL++     +  E  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE-- 142

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNP-LHLAAMSGYTKTIELLHSVHS 525
            +G TPL +A ++GH  VV  L+N G         R P LH+AA +  T+T  +L     
Sbjct: 143 -DGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 526 HLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY 563
           +  D + K G T LH+A      +   LLL+ G  +++
Sbjct: 198 NP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 60/258 (23%), Positives = 105/258 (40%), Gaps = 22/258 (8%)

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  G DIN  ++   + L LA+     + V  L+     ++         LH+  + G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG-- 89

Query: 374 LEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
                   +D   + L+     +N +   G +PL+ A++E H+  ++ L+  GA  N+  
Sbjct: 90  --------QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +PL  A + G  +    L++   GT          L  LHIA+R   TR   +LL 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINY--GT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                      G  PLH+AA        +LL +     ++   ++G T LH+A+      
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVI 253

Query: 550 SIALLLSMGCRLSYNNMD 567
            + LLL  G ++     D
Sbjct: 254 MVRLLLDRGAQIETKTKD 271


>M28880-1|AAA51732.1| 1880|Homo sapiens ankyrin protein.
          Length = 1880

 Score =  184 bits (449), Expect = 1e-45
 Identities = 155/555 (27%), Positives = 252/555 (45%), Gaps = 37/555 (6%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           + ++T  +  L+    A++ G+V   + L L +   L     +G TA H A+      ++
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVEL-LHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + NY  ++NA+   G TPL++A +   L+ +++LL+     +V  E    P+ +A + 
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY 183
              +V+        L N    G+    ALH AA +D    A +L+ + D         G+
Sbjct: 155 GHENVV------AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGF 207

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H AA   +    ++ L  G          ++     G  PLH A   G++  V L L
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGSS--------VNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             GA+I T+  D  TP+H A   G + I +++      +  A + +     ++PIH AA 
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQ 314

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
            DH + V  L+   ++I+ +  +  +PL +AA     R    L+  GA    + +N    
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 364 LHLVV-MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRL 422
           LH+    N  R+ +           + +  + E   +G +PLH AS  GH+  ++NL++ 
Sbjct: 375 LHIACKKNHVRVMELLLK-----TGASIDAVTE---SGLTPLHVASFMGHLPIVKNLLQR 426

Query: 423 GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           GA  N+ N   E+PLH AAR G    A  LL +      +N    +  TPLH A+R GHT
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHT 483

Query: 483 RVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI-ELLHSVHSHLLDQIDKDGNTSLH 540
            +V LLL   A  +     G  PLH+AA  G+ +T+  LL    S     + K G T LH
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLH 541

Query: 541 LATMENKPSSIALLL 555
           +A    K     LLL
Sbjct: 542 VAAKYGKVRVAELLL 556



 Score =  163 bits (396), Expect = 3e-39
 Identities = 140/527 (26%), Positives = 221/527 (41%), Gaps = 30/527 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L+  S +      G T  H AS R N  ++  + +    +  K     TPLH A  N
Sbjct: 223 QLLLNRGSSVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             +   E LL          +   +PIHMA + + +  +++  +Y +   ++       T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 340

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   H   AK+L+ D  A+      NG+ P+H A K    R +E+ L+ G     
Sbjct: 341 PLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--- 396

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                I      G  PLH A   G +  V+  L+ GA  +     + TP+H+A   G  +
Sbjct: 397 -----IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           + K  + +Q K K       D    TP+HCAA   H  +V  L+   ++ N       +P
Sbjct: 452 VAK--YLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSL 389
           L +AA      TV  L+   A            LH+    G  R+ +       H     
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---- 562

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
               N     G +PLH A    ++  ++ L+  G   +    N  +PLH AA+  +   A
Sbjct: 563 ----NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL         N    +G+TPLH+A++EGH  +V LLL++ A  +  + +G  PLHL 
Sbjct: 619 RSLLQYGGSA---NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A  G+    ++L   H  ++D   + G T LH+A+       +  LL
Sbjct: 676 AQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721



 Score =  160 bits (389), Expect = 2e-38
 Identities = 150/564 (26%), Positives = 239/564 (42%), Gaps = 52/564 (9%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+  +++  ++  L   +   V    G T    A  + + N++  + NY      K   
Sbjct: 118 AAQENHLE-VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKV 172

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
               LH+A  N+       LLQ      VL++    P+H+A     ++V Q+     S  
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGS-- 230

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           +VN   ++G T LH A+   + +  ++L+ D  A+ +    +   P+H AA+N   R  E
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L  G          I      G  P+H A  G  +  V L L+  A+I     D  TP
Sbjct: 290 ILLDHGAP--------IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G   + K++     K     L        TP+H A   +H  ++  L+  G+ 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNG-----FTPLHIACKKNHVRVMELLLKTGAS 396

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR------ 373
           I+ + +   +PL +A+       V  L++ GA   + ++     LH+    G        
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 374 LEDFA---ASCKD-----HC-----EKSLLQLLNEKD-------NTGCSPLHYASREGHI 413
           L++ A   A  KD     HC       ++++LL E +         G +PLH A+REGH+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            ++  L+   A          +PLH AA+YG+   A  LL+ D      N +   GLTPL
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPL 573

Query: 474 HIASREGHTRVVHLLLNRGALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           H+A    +  +V LLL RG   H    NG  PLH+AA     +    L   +    +   
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAES 632

Query: 533 KDGNTSLHLATMENKPSSIALLLS 556
             G T LHLA  E     +ALLLS
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLS 656



 Score =  144 bits (349), Expect = 2e-33
 Identities = 125/442 (28%), Positives = 191/442 (43%), Gaps = 26/442 (5%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N+  ++  +      ++A   +G TPLHVA     L  ++ LLQ+    
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +V N K + P+HMA       V +   + K+   VN   +  +T LH AA   H    K+
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKA--KVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 LITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           L+ + +A        G+ P+H AA+     T+   L+    + C  +        +G  P
Sbjct: 489 LLEN-NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK--------KGFTP 539

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A   G ++  EL L   A  +    +  TP+H+A     LDIVKL+   +    H  
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPH-- 596

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
             S      TP+H AA  +  E+   L+  G   N    +  +PL LAA       V  L
Sbjct: 597 --SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +   A+  L + +    LHLV   G           D   K  + +++     G +PLH 
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEG------HVPVADVLIKHGV-MVDATTRMGYTPLHV 707

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           AS  G+I+ ++ L++  A +N K     SPLH AA+ G       LL +       NE  
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVS 764

Query: 467 GEGLTPLHIASREGHTRVVHLL 488
            +G TPL IA R G+  V  +L
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVL 786



 Score =  139 bits (336), Expect = 6e-32
 Identities = 124/519 (23%), Positives = 218/519 (42%), Gaps = 28/519 (5%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF 65
           +   TK  LS    AA+  ++D  +RL L   + +        T  H A+   +  +   
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 66  INNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNK 125
           + +     N++   G TPLH+A +   +  +E LL+       + E    P+H+A+ +  
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 126 VSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYP 185
           + +++   +  +  NV+       T LH AA   H   AK L+ +  A+      +   P
Sbjct: 417 LPIVKNLLQRGASPNVSN--VKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTP 473

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +H AA+   +  +++ L+             +L    G+ PLH A   G ++ V   L  
Sbjct: 474 LHCAARIGHTNMVKLLLE--------NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFD 305
            A  +       TP+H+A   G + + +L+      E+ A   +     +TP+H A   +
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLL-----ERDAHPNAAGKNGLTPLHVAVHHN 580

Query: 306 HPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           + +IV  L+  G   +       +PL +AA +       +L++ G     + +     LH
Sbjct: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640

Query: 366 LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGAC 425
           L    G   E  A         +L       + +G +PLH  ++EGH+   + LI+ G  
Sbjct: 641 LAAQEG-HAEMVALLLSKQANGNL------GNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++       +PLH A+ YG       LL        +N     G +PLH A+++GHT +V
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 486 HLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            LLL  GA  +    +G  PL +A   GY    ++L  V
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789



 Score =  116 bits (279), Expect = 5e-25
 Identities = 116/446 (26%), Positives = 191/446 (42%), Gaps = 36/446 (8%)

Query: 100 LQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD 159
           L+  V+ +  N+     +H+A++   V ++ V   +K +  +    + G TALH AA+  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMV-VELLHKEII-LETTTKKGNTALHIAALAG 89

Query: 160 HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
            D   + L+ +  A        G+ P++ AA+      ++  L+ G  +    E      
Sbjct: 90  QDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE------ 142

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
             +G  PL  A+  G    V   +  G K   +   L    H+A          ++    
Sbjct: 143 --DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL----HIAARNDDTRTAAVLLQND 196

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
           P       T       TP+H AA +++  +   L+N GS +N   +   +PL +A+ R  
Sbjct: 197 PNPDVLSKTG-----FTPLHIAAHYENLNVAQLLLNRGSSVNFTPQNGITPLHIASRRGN 251

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQLLNEKDN 398
              V  L+  GA I+ K  +    LH    NG  R+ +      DH        +  K  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL---DHGAP-----IQAKTK 303

Query: 399 TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
            G SP+H A++  H+  +  L++  A I+    ++ +PLH AA  G    A  LL  DKG
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL--DKG 361

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTI 517
               N     G TPLHIA ++ H RV+ LLL  GA +     +G  PLH+A+  G+   +
Sbjct: 362 A-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 518 E-LLHSVHSHLLDQIDKDGNTSLHLA 542
           + LL    S  +  +  +  T LH+A
Sbjct: 421 KNLLQRGASPNVSNVKVE--TPLHMA 444



 Score =  109 bits (262), Expect = 6e-23
 Identities = 100/357 (28%), Positives = 164/357 (45%), Gaps = 33/357 (9%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L +A  G   KA++  LR+G  I+T   +    +HLA  +G    VK++  +  KE    
Sbjct: 17  LRAARSGNLDKALDH-LRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKE--II 70

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           L +   +  T +H AA+    E+V  L+N G+++N   ++  +PL +AA       V  L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 347 IRLGAD-------------IQLKDINSRNVLHLV---VMNGGRLEDFAASCKDHCEKSLL 390
           +  GA+             + L+  +   V HL+        RL     + ++   ++  
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 391 QLLNEKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
            LL    N      TG +PLH A+   ++   + L+  G+ +N    N  +PLH A+R G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGSSVNFTPQNGITPLHIASRRG 250

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRN 503
                  LL  D+G  I  ++  E LTPLH A+R GH R+  +LL+ GA +  +  NG +
Sbjct: 251 NVIMVRLLL--DRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
           P+H+AA   +   + LL    +  +D I  D  T LH+A          +LL  G +
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAE-IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363



 Score = 97.9 bits (233), Expect = 2e-19
 Identities = 102/387 (26%), Positives = 161/387 (41%), Gaps = 34/387 (8%)

Query: 179 CN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK 237
           CN NG   +H A+K    + +   L         +E ++     +GN  LH A   G  +
Sbjct: 41  CNQNGLNGLHLASKEGHVKMVVELLH--------KEIILETTTKKGNTALHIAALAGQDE 92

Query: 238 AVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTP 297
            V   +  GA ++ Q     TP+++A  +  L++VK +      E  A          TP
Sbjct: 93  VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL-----ENGANQNVATEDGFTP 147

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +  A    H  +V +LIN G+      K R   L +AA     RT   L++   +  +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
                 LH+        E+   +       +    +N     G +PLH ASR G++  + 
Sbjct: 204 KTGFTPLHIAA----HYENLNVA---QLLLNRGSSVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
            L+  GA I  K  +  +PLH AAR G    +  LLD       I      GL+P+H+A+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIHMAA 313

Query: 478 REGHTRVVHLLLNRGALLHR---DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
           +  H   V LLL   A +     DH    PLH+AA  G+ +  ++L    +    +   +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370

Query: 535 GNTSLHLATMENKPSSIALLLSMGCRL 561
           G T LH+A  +N    + LLL  G  +
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASI 397



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 61/258 (23%), Positives = 106/258 (41%), Gaps = 22/258 (8%)

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  G DIN  ++   + L LA+     + V  L+     ++         LH+  + G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG-- 89

Query: 374 LEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
                   +D   + L+     +N +   G +PL+ A++E H+  ++ L+  GA  N+  
Sbjct: 90  --------QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +PL  A + G  +    L++   GT          L  LHIA+R   TR   +LL 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINY--GT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                      G  PLH+AA        +LL +  S + +   ++G T LH+A+      
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGSSV-NFTPQNGITPLHIASRRGNVI 253

Query: 550 SIALLLSMGCRLSYNNMD 567
            + LLL  G ++     D
Sbjct: 254 MVRLLLDRGAQIETKTKD 271


>AB209418-1|BAD92655.1| 1899|Homo sapiens ankyrin 1 isoform 4
           variant protein.
          Length = 1899

 Score =  184 bits (449), Expect = 1e-45
 Identities = 156/555 (28%), Positives = 254/555 (45%), Gaps = 37/555 (6%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           + ++T  +  L+    A++ G+V   + L L +   L     +G TA H A+      ++
Sbjct: 71  VDINTCNQNGLNGLHLASKEGHVKMVVEL-LHKEIILETTTKKGNTALHIAALAGQDEVV 129

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + NY  ++NA+   G TPL++A +   L+ +++LL+     +V  E    P+ +A + 
Sbjct: 130 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 189

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY 183
              +V+        L N    G+    ALH AA +D    A +L+ + D         G+
Sbjct: 190 GHENVV------AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGF 242

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H AA   +    ++ L     RG +    ++     G  PLH A   G++  V L L
Sbjct: 243 TPLHIAAHYENLNVAQLLL----NRGAS----VNFTPQNGITPLHIASRRGNVIMVRLLL 294

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             GA+I T+  D  TP+H A   G + I +++      +  A + +     ++PIH AA 
Sbjct: 295 DRGAQIETKTKDELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQ 349

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
            DH + V  L+   ++I+ +  +  +PL +AA     R    L+  GA    + +N    
Sbjct: 350 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 409

Query: 364 LHLVV-MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRL 422
           LH+    N  R+ +           + +  + E   +G +PLH AS  GH+  ++NL++ 
Sbjct: 410 LHIACKKNHVRVMELLLK-----TGASIDAVTE---SGLTPLHVASFMGHLPIVKNLLQR 461

Query: 423 GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           GA  N+ N   E+PLH AAR G    A  LL +      +N    +  TPLH A+R GHT
Sbjct: 462 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHT 518

Query: 483 RVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI-ELLHSVHSHLLDQIDKDGNTSLH 540
            +V LLL   A  +     G  PLH+AA  G+ +T+  LL    S     + K G T LH
Sbjct: 519 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLH 576

Query: 541 LATMENKPSSIALLL 555
           +A    K     LLL
Sbjct: 577 VAAKYGKVRVAELLL 591



 Score =  162 bits (393), Expect = 8e-39
 Identities = 139/527 (26%), Positives = 221/527 (41%), Gaps = 30/527 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L+  + +      G T  H AS R N  ++  + +    +  K     TPLH A  N
Sbjct: 258 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 317

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             +   E LL          +   +PIHMA + + +  +++  +Y +   ++       T
Sbjct: 318 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 375

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   H   AK+L+ D  A+      NG+ P+H A K    R +E+ L+ G     
Sbjct: 376 PLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--- 431

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                I      G  PLH A   G +  V+  L+ GA  +     + TP+H+A   G  +
Sbjct: 432 -----IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 486

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           + K  + +Q K K       D    TP+HCAA   H  +V  L+   ++ N       +P
Sbjct: 487 VAK--YLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 541

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSL 389
           L +AA      TV  L+   A            LH+    G  R+ +       H     
Sbjct: 542 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---- 597

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
               N     G +PLH A    ++  ++ L+  G   +    N  +PLH AA+  +   A
Sbjct: 598 ----NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 653

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL         N    +G+TPLH+A++EGH  +V LLL++ A  +  + +G  PLHL 
Sbjct: 654 RSLLQYGGSA---NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 710

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A  G+    ++L   H  ++D   + G T LH+A+       +  LL
Sbjct: 711 AQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 756



 Score =  160 bits (388), Expect = 3e-38
 Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 28/508 (5%)

Query: 50  AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           A H A+  ++T     +     + +     G TPLH+A   E L+  + LL +    +  
Sbjct: 211 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 270

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
            +    P+H+A+    V ++++     +        E   T LH AA + H   ++IL+ 
Sbjct: 271 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILL- 327

Query: 170 DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHS 229
           D  A  +    NG  PIH AA+      + + LQ+  +        I     +   PLH 
Sbjct: 328 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE--------IDDITLDHLTPLHV 379

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A H G  +  ++ L  GAK +++  +  TP+H+AC +  + +++L+      +  A + +
Sbjct: 380 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-----KTGASIDA 434

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
                +TP+H A+   H  IV  L+  G+  N  + +  +PL +AA          L++ 
Sbjct: 435 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 494

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
            A +  K  + +  LH     G          +++   +L          G +PLH A+R
Sbjct: 495 KAKVNAKAKDDQTPLHCAARIG-HTNMVKLLLENNANPNLAT------TAGHTPLHIAAR 547

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           EGH+ ++  L+   A          +PLH AA+YG+   A  LL+ D      N +   G
Sbjct: 548 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNG 604

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           LTPLH+A    +  +V LLL RG   H    NG  PLH+AA     +    L   +    
Sbjct: 605 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSA 663

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLS 556
           +     G T LHLA  E     +ALLLS
Sbjct: 664 NAESVQGVTPLHLAAQEGHAEMVALLLS 691



 Score =  144 bits (349), Expect = 2e-33
 Identities = 125/442 (28%), Positives = 191/442 (43%), Gaps = 26/442 (5%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N+  ++  +      ++A   +G TPLHVA     L  ++ LLQ+    
Sbjct: 406 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 465

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +V N K + P+HMA       V +   + K+   VN   +  +T LH AA   H    K+
Sbjct: 466 NVSNVKVETPLHMAARAGHTEVAKYLLQNKA--KVNAKAKDDQTPLHCAARIGHTNMVKL 523

Query: 167 LITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           L+ + +A        G+ P+H AA+     T+   L+    + C  +        +G  P
Sbjct: 524 LLEN-NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK--------KGFTP 574

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A   G ++  EL L   A  +    +  TP+H+A     LDIVKL+   +    H  
Sbjct: 575 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPH-- 631

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
             S      TP+H AA  +  E+   L+  G   N    +  +PL LAA       V  L
Sbjct: 632 --SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 689

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +   A+  L + +    LHLV   G           D   K  + +++     G +PLH 
Sbjct: 690 LSKQANGNLGNKSGLTPLHLVAQEG------HVPVADVLIKHGV-MVDATTRMGYTPLHV 742

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           AS  G+I+ ++ L++  A +N K     SPLH AA+ G       LL +       NE  
Sbjct: 743 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP---NEVS 799

Query: 467 GEGLTPLHIASREGHTRVVHLL 488
            +G TPL IA R G+  V  +L
Sbjct: 800 SDGTTPLAIAKRLGYISVTDVL 821



 Score =  139 bits (336), Expect = 6e-32
 Identities = 124/519 (23%), Positives = 218/519 (42%), Gaps = 28/519 (5%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF 65
           +   TK  LS    AA+  ++D  +RL L   + +        T  H A+   +  +   
Sbjct: 333 IQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 391

Query: 66  INNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNK 125
           + +     N++   G TPLH+A +   +  +E LL+       + E    P+H+A+ +  
Sbjct: 392 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 451

Query: 126 VSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYP 185
           + +++   +  +  NV+       T LH AA   H   AK L+ +  A+      +   P
Sbjct: 452 LPIVKNLLQRGASPNVSN--VKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTP 508

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +H AA+   +  +++ L+             +L    G+ PLH A   G ++ V   L  
Sbjct: 509 LHCAARIGHTNMVKLLLE--------NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 560

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFD 305
            A  +       TP+H+A   G + + +L+      E+ A   +     +TP+H A   +
Sbjct: 561 EASQACMTKKGFTPLHVAAKYGKVRVAELLL-----ERDAHPNAAGKNGLTPLHVAVHHN 615

Query: 306 HPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           + +IV  L+  G   +       +PL +AA +       +L++ G     + +     LH
Sbjct: 616 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 675

Query: 366 LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGAC 425
           L    G   E  A         +L       + +G +PLH  ++EGH+   + LI+ G  
Sbjct: 676 LAAQEG-HAEMVALLLSKQANGNL------GNKSGLTPLHLVAQEGHVPVADVLIKHGVM 728

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++       +PLH A+ YG       LL        +N     G +PLH A+++GHT +V
Sbjct: 729 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 785

Query: 486 HLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            LLL  GA  +    +G  PL +A   GY    ++L  V
Sbjct: 786 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 824



 Score =  118 bits (285), Expect = 9e-26
 Identities = 122/478 (25%), Positives = 204/478 (42%), Gaps = 37/478 (7%)

Query: 68  NYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVS 127
           N + D   K +A  + L  A       A+++L +  V+ +  N+     +H+A++   V 
Sbjct: 36  NRSRDRKKKADAATSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVK 94

Query: 128 VLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIH 187
           ++ V   +K +  +    + G TALH AA+   D   + L+ +  A        G+ P++
Sbjct: 95  MV-VELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLY 151

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA+      ++  L+ G  +    E        +G  PL  A+  G    V   +  G 
Sbjct: 152 MAAQENHLEVVKFLLENGANQNVATE--------DGFTPLAVALQQGHENVVAHLINYGT 203

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHP 307
           K   +   L    H+A          ++    P       T       TP+H AA +++ 
Sbjct: 204 KGKVRLPAL----HIAARNDDTRTAAVLLQNDPNPDVLSKTG-----FTPLHIAAHYENL 254

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
            +   L+N G+ +N   +   +PL +A+ R     V  L+  GA I+ K  +    LH  
Sbjct: 255 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 314

Query: 368 VMNGG-RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACI 426
             NG  R+ +      DH        +  K   G SP+H A++  H+  +  L++  A I
Sbjct: 315 ARNGHVRISEILL---DHGAP-----IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 366

Query: 427 NLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVH 486
           +    ++ +PLH AA  G    A  LL  DKG    N     G TPLHIA ++ H RV+ 
Sbjct: 367 DDITLDHLTPLHVAAHCGHHRVAKVLL--DKGA-KPNSRALNGFTPLHIACKKNHVRVME 423

Query: 487 LLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIE-LLHSVHSHLLDQIDKDGNTSLHLA 542
           LLL  GA +     +G  PLH+A+  G+   ++ LL    S  +  +  +  T LH+A
Sbjct: 424 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--TPLHMA 479



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 102/387 (26%), Positives = 161/387 (41%), Gaps = 34/387 (8%)

Query: 179 CN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK 237
           CN NG   +H A+K    + +   L         +E ++     +GN  LH A   G  +
Sbjct: 76  CNQNGLNGLHLASKEGHVKMVVELLH--------KEIILETTTKKGNTALHIAALAGQDE 127

Query: 238 AVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTP 297
            V   +  GA ++ Q     TP+++A  +  L++VK +      E  A          TP
Sbjct: 128 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL-----ENGANQNVATEDGFTP 182

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +  A    H  +V +LIN G+      K R   L +AA     RT   L++   +  +  
Sbjct: 183 LAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 238

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
                 LH+        E+   +       +    +N     G +PLH ASR G++  + 
Sbjct: 239 KTGFTPLHIAA----HYENLNVA---QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 291

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
            L+  GA I  K  +  +PLH AAR G    +  LLD       I      GL+P+H+A+
Sbjct: 292 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIHMAA 348

Query: 478 REGHTRVVHLLLNRGALLHR---DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
           +  H   V LLL   A +     DH    PLH+AA  G+ +  ++L    +    +   +
Sbjct: 349 QGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 405

Query: 535 GNTSLHLATMENKPSSIALLLSMGCRL 561
           G T LH+A  +N    + LLL  G  +
Sbjct: 406 GFTPLHIACKKNHVRVMELLLKTGASI 432



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 62/218 (28%), Positives = 97/218 (44%), Gaps = 16/218 (7%)

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +R G DI   + N  N LHL    G          K+     +L+   +K NT    LH 
Sbjct: 67  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE----IILETTTKKGNTA---LHI 119

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+  G    +  L+  GA +N ++    +PL+ AA+         LL++     +  E  
Sbjct: 120 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE-- 177

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNP-LHLAAMSGYTKTIELLHSVHS 525
            +G TPL +A ++GH  VV  L+N G         R P LH+AA +  T+T  +L     
Sbjct: 178 -DGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDP 232

Query: 526 HLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY 563
           +  D + K G T LH+A      +   LLL+ G  +++
Sbjct: 233 NP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 269



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 60/258 (23%), Positives = 105/258 (40%), Gaps = 22/258 (8%)

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  G DIN  ++   + L LA+     + V  L+     ++         LH+  + G  
Sbjct: 67  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG-- 124

Query: 374 LEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
                   +D   + L+     +N +   G +PL+ A++E H+  ++ L+  GA  N+  
Sbjct: 125 --------QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 176

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +PL  A + G  +    L++   GT          L  LHIA+R   TR   +LL 
Sbjct: 177 EDGFTPLAVALQQGHENVVAHLINY--GT-----KGKVRLPALHIAARNDDTRTAAVLLQ 229

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                      G  PLH+AA        +LL +     ++   ++G T LH+A+      
Sbjct: 230 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN-RGASVNFTPQNGITPLHIASRRGNVI 288

Query: 550 SIALLLSMGCRLSYNNMD 567
            + LLL  G ++     D
Sbjct: 289 MVRLLLDRGAQIETKTKD 306


>AB002377-1|BAA20833.2| 1059|Homo sapiens KIAA0379 protein protein.
          Length = 1059

 Score =  177 bits (431), Expect = 2e-43
 Identities = 167/604 (27%), Positives = 260/604 (43%), Gaps = 43/604 (7%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG   D  R  LS    +   D  GRT  H A+A  N   L+ + N   D N KD  
Sbjct: 385 AALSG-FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 443

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH-MATELNKVSVLQVFAKYKSL 138
           G +PLH A  N     +  L+      + L+E+   P+H  AT       L+   +  + 
Sbjct: 444 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA- 502

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILI--TDLD-------AEWKKPCNN--GYYPIH 187
            N     + G  A+H++A + H LC +++   T LD        +     +N     P+H
Sbjct: 503 -NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 561

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA +   + +EV +Q            + + ++ G  PL  A   G ++ V++ +  GA
Sbjct: 562 LAAYHGHHQALEVLVQ--------SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 613

Query: 248 KISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDH 306
            I  + + L  TP+H A   G  + ++L+  +   E    +   D    TP+  + +  H
Sbjct: 614 SILVKDYILKRTPIHAAATNGHSECLRLL--IGNAEPQNAVDIQDGNGQTPLMLSVLNGH 671

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            + V  L+N+G++++  DK  R+ L   A       V  L++ GA   L+D   R  +HL
Sbjct: 672 TDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 731

Query: 367 VVMNG-----GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIR 421
               G     G L   AAS   +   +        DN G + LH+A   GH   +E L+ 
Sbjct: 732 SAACGHIGVLGALLQSAASMDANPATA--------DNHGYTALHWACYNGHETCVELLLE 783

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
                     N  SPLH A        A  L+D+  G  I+N +D +G TPLH A+   H
Sbjct: 784 -QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-LGASIVNATDSKGRTPLHAAAFTDH 841

Query: 482 TRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
              + LLL+  A ++  D  G+ PL +AA +G T T+E+L S  S  L   D   NT+LH
Sbjct: 842 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 901

Query: 541 LATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVTHEQRAKEVMALR 600
           LA  +   +S  L+L      +  N   +A+   ++       L MV  E   K    L 
Sbjct: 902 LACSKGHETSALLILEKITDRNLINATNAALQTPLHVA-ARNGLTMVVQELLGKGASVLA 960

Query: 601 SDRH 604
            D +
Sbjct: 961 VDEN 964



 Score =  153 bits (372), Expect = 3e-36
 Identities = 145/537 (27%), Positives = 235/537 (43%), Gaps = 55/537 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           VQA  +G+ D+ +R  + +   +  +D   RT  H A+   +  I+  +      +NAKD
Sbjct: 19  VQAIFNGDPDE-VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 77

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           +   TPLH AV + + +A++ LL+   + +  ++  Q P+H+A     V   +  A    
Sbjct: 78  SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE--ALVPL 135

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGYYPIHEAAKNAS 194
           L NVN     GRTALH AA   H    K+L++   +++A  KK        IH AA    
Sbjct: 136 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR----AIHWAAYMGH 191

Query: 195 SRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
              +++ +  G +  C         D +   PLH+A   G I  V+  L  G  ++    
Sbjct: 192 IEVVKLLVSHGAEVTCK--------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 243

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI-VNYL 313
             +TP+H+AC  G   +V  +      +  A +   + +  TP+H AA   H  + +  L
Sbjct: 244 YGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 298

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  G+D+N   K+ ++PL + A    +    T+I+ GA I  +D N    LH+    G  
Sbjct: 299 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 358

Query: 374 L---------EDFA---------------ASCKDHCEKSLLQ--LLNEKDNTGCSPLHYA 407
           L          D A               +   D C K L     ++  D+ G + LH A
Sbjct: 359 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 418

Query: 408 SREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDG 467
           +  G++  L  L+  GA  N K+    SPLH+AA    +     L+ S      +N+ D 
Sbjct: 419 AAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGAS---VNDLDE 475

Query: 468 EGLTPLHIA--SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS 522
            G TPLH A  S      + +LL N      RD  G N +H +A  G+   ++L+ S
Sbjct: 476 RGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS 532



 Score =  126 bits (303), Expect = 6e-28
 Identities = 109/378 (28%), Positives = 166/378 (43%), Gaps = 30/378 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H AA    +  IE+ +  G +        ++  D++   PLH AV     +AV++ L+
Sbjct: 50  PLHAAAYLGDAEIIELLILSGAR--------VNAKDSKWLTPLHRAVASCSEEAVQVLLK 101

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
             A ++ +  +  TP+H+A A  A   VK    + P   +  ++  D    T +H AA  
Sbjct: 102 HSADVNARDKNWQTPLHIAAANKA---VKCAEALVPLLSNVNVS--DRAGRTALHHAAFS 156

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
            H E+V  L++ G++IN  DK+ R  +  AA       V  L+  GA++  KD  S   L
Sbjct: 157 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 216

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           H    +G               K LL L   +NE +  G +PLH A   G    +  LI 
Sbjct: 217 HAAASSG----------MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID 266

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
            GA +N KN    +PLHFAA         +LL  +     +N    +G TPLH+ +  G 
Sbjct: 267 CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD--VNMKSKDGKTPLHMTALHGR 324

Query: 482 TRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
                 ++  GA++   D NG  PLH+AA  G+   I  L +  +    +    G   LH
Sbjct: 325 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR-GIHGMFPLH 383

Query: 541 LATMENKPSSIALLLSMG 558
           LA +         LLS G
Sbjct: 384 LAALSGFSDCCRKLLSSG 401



 Score =  119 bits (286), Expect = 7e-26
 Identities = 91/335 (27%), Positives = 157/335 (46%), Gaps = 20/335 (5%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A+  GD   V   +     ++ Q ++  TP+H A   G  +I++L+         A 
Sbjct: 18  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLIL-----SGAR 72

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           + + D + +TP+H A      E V  L+   +D+N  DK  ++PL +AA+    +    L
Sbjct: 73  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 132

Query: 347 IRLGADIQLKDINSRNVLHLVVMNG-GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           + L +++ + D   R  LH    +G G +     S       + +   ++KD      +H
Sbjct: 133 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS-----RGANINAFDKKDRRA---IH 184

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
           +A+  GHI  ++ L+  GA +  K+  + +PLH AA  G       LLD       +NE 
Sbjct: 185 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD---MNEP 241

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGY-TKTIELLHSV 523
           +  G TPLH+A   G   VV+ L++ GA+++ ++  G  PLH AA S +    +ELL   
Sbjct: 242 NAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG- 300

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           +   ++   KDG T LH+  +  + S    ++  G
Sbjct: 301 NGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 335



 Score =  116 bits (278), Expect = 7e-25
 Identities = 127/504 (25%), Positives = 208/504 (41%), Gaps = 37/504 (7%)

Query: 61  NILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           N +H+   Y   L  +  A  TPL V +E    D +         +   N    +P+H+A
Sbjct: 513 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML---------SDSDNRATISPLHLA 563

Query: 121 TELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN 180
                   L+V  +  SL +++     GRT L  AA   H  C  +LI    +   K   
Sbjct: 564 AYHGHHQALEVLVQ--SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 621

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               PIH AA N  S  + + +   E +       + + D  G  PL  +V  G    V 
Sbjct: 622 LKRTPIHAAATNGHSECLRLLIGNAEPQNA-----VDIQDGNGQTPLMLSVLNGHTDCVY 676

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             L  GA +  +     T +H     G  + V  +     K    CL   D +  TPIH 
Sbjct: 677 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK----CLLR-DSRGRTPIHL 731

Query: 301 AAMFDHPEIVNYLINEGS--DINPLDKERRSPLLLA-ASRAGWRTVHTLIRLGADIQLKD 357
           +A   H  ++  L+   +  D NP   +      L  A   G  T   L+      Q  +
Sbjct: 732 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 791

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
            N+ + LH  V+N    E  A    D    S++   N  D+ G +PLH A+   H+  L+
Sbjct: 792 GNAFSPLHCAVINDN--EGAAEMLIDTLGASIV---NATDSKGRTPLHAAAFTDHVECLQ 846

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
            L+   A +N  ++  ++PL  AA  G+ +T   L+ S      + ++     T LH+A 
Sbjct: 847 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN--TALHLAC 904

Query: 478 REGHTRVVHLLL----NRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
            +GH     L+L    +R  +   +   + PLH+AA +G T  ++ L    + +L  +D+
Sbjct: 905 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVL-AVDE 963

Query: 534 DGNT-SLHLATMENKPSSIALLLS 556
           +G T +L  A  ++    +AL+L+
Sbjct: 964 NGYTPALACAPNKDVADCLALILA 987



 Score =  105 bits (253), Expect = 7e-22
 Identities = 99/402 (24%), Positives = 168/402 (41%), Gaps = 20/402 (4%)

Query: 40  LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA-GNTPLHVAVENEALDAIEY 98
           L VR+  GRT    A+ + +   +  + N    +  KD     TP+H A  N   + +  
Sbjct: 582 LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 641

Query: 99  LL---QQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFA 155
           L+   +      + +   Q P+ M + LN  +   V++      NV+   + GRTALH  
Sbjct: 642 LIGNAEPQNAVDIQDGNGQTPL-MLSVLNGHTDC-VYSLLNKGANVDAKDKWGRTALHRG 699

Query: 156 AIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQM 215
           A+  H+ C   L+    A+     + G  PIH +A       +   LQ       + +  
Sbjct: 700 AVTGHEECVDALLQH-GAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ----SAASMDAN 754

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
            +  DN G   LH A + G    VEL L       T+ +  S P+H A         +++
Sbjct: 755 PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEML 813

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                    + + + D +  TP+H AA  DH E +  L++  + +N +D   ++PL++AA
Sbjct: 814 IDTLGA---SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 870

Query: 336 SRAGWRTVHTLIR-LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
                 TV  L+    A++ L+D +    LHL    G          K   +++L+   N
Sbjct: 871 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKI-TDRNLINATN 929

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
               T   PLH A+R G    ++ L+  GA +   + N  +P
Sbjct: 930 AALQT---PLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 968



 Score =  103 bits (247), Expect = 4e-21
 Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 13/279 (4%)

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
           D +K TP+H AA     EI+  LI  G+ +N  D +  +PL  A +      V  L++  
Sbjct: 44  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 103

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+A+  
Sbjct: 104 ADVNARDKNWQTPLHIAAANK------AVKCAE-ALVPLLSNVNVSDRAGRTALHHAAFS 156

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH   ++ L+  GA IN  +  +   +H+AA  G      +LL S      +   D +  
Sbjct: 157 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV-KLLVSHGAE--VTCKDKKSY 213

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           TPLH A+  G   VV  LL+ G  ++  +  G  PLH+A  +G    +  L    + +++
Sbjct: 214 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA-IVN 272

Query: 530 QIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           Q ++ G T LH A      +  + LL+  G  ++  + D
Sbjct: 273 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 311



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 69/319 (21%), Positives = 143/319 (44%), Gaps = 20/319 (6%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNT 82
           +G+ D    L L++ + +  +D  GRTA H+ +   +   +  +  +      +D+ G T
Sbjct: 669 NGHTDCVYSL-LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 727

Query: 83  PLHVAVENEALDAIEYLLQQ----HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           P+H++     +  +  LLQ         +  +      +H A      + +++  + + +
Sbjct: 728 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE-QEV 786

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN-GYYPIHEAAKNASSRT 197
           F   +G     + LH A I+D++  A++LI  L A      ++ G  P+H AA       
Sbjct: 787 FQKTEGNAF--SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 844

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDL 256
           +++ L    Q        ++  D+ G  PL  A   G    VE+ + S  A+++ Q +  
Sbjct: 845 LQLLLSHNAQ--------VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 896

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
           +T +HLAC++G  +   L+   +  +++  + + +    TP+H AA      +V  L+ +
Sbjct: 897 NTALHLACSKGH-ETSALLILEKITDRNL-INATNAALQTPLHVAARNGLTMVVQELLGK 954

Query: 317 GSDINPLDKERRSPLLLAA 335
           G+ +  +D+   +P L  A
Sbjct: 955 GASVLAVDENGYTPALACA 973



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD---LN 74
           + AAE+G  +    L  S  + L ++D    TA H A ++ +      I     D   +N
Sbjct: 867 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 926

Query: 75  AKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAP 116
           A + A  TPLHVA  N     ++ LL +      ++E    P
Sbjct: 927 ATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 968


>Z26634-1|CAB42644.1| 3925|Homo sapiens ankyrin B (440 kDa) protein.
          Length = 3925

 Score =  175 bits (425), Expect = 1e-42
 Identities = 140/548 (25%), Positives = 246/548 (44%), Gaps = 35/548 (6%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F++AA +GN+D  +  YL     +   +  G  A H A+   +  ++  +      +++ 
Sbjct: 35  FLRAARAGNLDKVVE-YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+++    +  ++    P++MA + N + V++   +  
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  N +   E G T L  A    H+    IL+  D   + + P       +H AA+   +
Sbjct: 154 A--NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA------LHIAARKDDT 205

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           ++  + LQ         + M++     G  PLH A H G++    L L  GA +     +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H+A  +G  ++VKL+      ++   + +     +TP+HCAA   H ++V  L+ 
Sbjct: 266 GITPLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
            G+ +    K   SPL +AA       V  L++  A +    ++    LH+         
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV--------- 371

Query: 376 DFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
             AA C  +   K LL      N +   G +PLH A ++  I+ +E L++ GA I     
Sbjct: 372 --AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
           +  +P+H AA  G  +    LL +     + N     G T LH+A+R G   VV  LL  
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI---RGETALHMAARAGQVEVVRCLLRN 486

Query: 492 GALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GAL+  R    + PLH+A+  G T+ ++LL    +H  D    +G T LH++  E +   
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH-PDAATTNGYTPLHISAREGQVDV 545

Query: 551 IALLLSMG 558
            ++LL  G
Sbjct: 546 ASVLLEAG 553



 Score =  167 bits (405), Expect = 3e-40
 Identities = 150/547 (27%), Positives = 239/547 (43%), Gaps = 35/547 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GNV+    L L+  + +      G T  H AS R NTN++  + +  G ++AK   
Sbjct: 240 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  +     +E LL++        +   +P+HMA + + V  ++   ++K+  
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-- 356

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            V+       TALH AA   H    K+L+ D  A       NG+ P+H A K    + +E
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVME 415

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +++G          I      G  P+H A   G +  V L L++GA          T 
Sbjct: 416 LLVKYGAS--------IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 467

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G +++V+ +         A + +   ++ TP+H A+     EIV  L+   + 
Sbjct: 468 LHMAARAGQVEVVRCLL-----RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
            +       +PL ++A          L+  GA   L        LH+    G    D A 
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL--DVA- 579

Query: 380 SCKDHCEKSLLQLLNEKDN---TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  K LLQ     D+    G +PLH A+   + +    L+  GA  +    N  +P
Sbjct: 580 -------KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH AA+  +   A  LL+    T I+ +   +G+TPLH+AS+EGHT +V LLL++GA +H
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 497 RD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
               +G   LHLAA        ++L + H    D   K G T L +A        +  LL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL-TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 556 SMGCRLS 562
             G  ++
Sbjct: 749 KQGANVN 755



 Score =  138 bits (334), Expect = 1e-31
 Identities = 114/476 (23%), Positives = 199/476 (41%), Gaps = 27/476 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NA+   G TPLH+A +   +  +E L++       
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  ++++ +  +  +  +V      G TALH AA        + L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN--IRGETALHMAARAGQVEVVRCLL 484

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            +  A           P+H A++   +  +++ LQ                   G  PLH
Sbjct: 485 RN-GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT--------TNGYTPLH 535

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G +    + L +GA  S       TP+H+A   G+LD+ KL+      ++ A   
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAAD 590

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           S     +TP+H AA +D+ ++   L+ +G+  +   K   +PL +AA +   +   TL+ 
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GA+  +        LHL    G    D      D         ++    +G + LH A+
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHT--DMVTLLLDKGAN-----IHMSTKSGLTSLHLAA 703

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   + L + GA  +       +PL  A  YG       LL        +N     
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKN 760

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL  GA  +    NG   L +A   GY   ++ L  V
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 816



 Score =  132 bits (320), Expect = 5e-30
 Identities = 121/458 (26%), Positives = 192/458 (41%), Gaps = 26/458 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L + +    R   G T  H A  +N   ++  +  Y   + A   +G TP+HVA   
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             L+ +  LLQ      V N + +  +HMA    +V V++   +  +L +     E  +T
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE--QT 499

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH A+        ++L+  + A       NGY P+H +A+        V L+ G     
Sbjct: 500 PLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-- 556

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                 SL   +G  PLH A   G +   +L L+  A   +   +  TP+H+A       
Sbjct: 557 ------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           +  L+      EK A   +      TP+H AA  +  +I + L+N G++ N + K+  +P
Sbjct: 611 VALLLL-----EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L LA+       V  L+  GA+I +   +    LHL        ED         +    
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-----EDKVNVADILTKHGAD 720

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
           Q  + K   G +PL  A   G+++ +  L++ GA +N K  N  +PLH AA+ G  H   
Sbjct: 721 QDAHTK--LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIIN 778

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
            LL         N +   G T L IA R G+  VV  L
Sbjct: 779 VLLQHGAKP---NATTANGNTALAIAKRLGYISVVDTL 813



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 67/251 (26%), Positives = 108/251 (43%), Gaps = 24/251 (9%)

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG--GRLEDFAA 379
           P   +  +  L AA       V   ++ G DI   + N  N LHL    G  G +++   
Sbjct: 26  PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
                   S +    +K NT    LH AS  G    ++ L++ GA IN ++ N  +PL+ 
Sbjct: 86  ------RGSSVDSATKKGNTA---LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 136

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+         LL++        E   +G TPL +A ++GH + V +LL       +  
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDT---KGK 190

Query: 500 NGRNPLHLAAMSGYTKTIELL----HS--VHSHLL-DQIDKDGNTSLHLATMENKPSSIA 552
                LH+AA    TK+  LL    H+  V S ++ ++  + G T LH+A      +   
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 553 LLLSMGCRLSY 563
           LLL+ G  + +
Sbjct: 251 LLLNRGAAVDF 261



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 70/270 (25%), Positives = 115/270 (42%), Gaps = 27/270 (10%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           ++V YL   G DIN  ++   + L LAA       V  L+  G+ +          LH+ 
Sbjct: 46  KVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
            +  G+ E      K+         +N +   G +PL+ A++E HI  ++ L+  GA  +
Sbjct: 105 SL-AGQAEVVKVLVKEGAN------INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSD-KGTFIINESDGEGLTPLHIASREGHTRVVH 486
               +  +PL  A + G       LL++D KG           L  LHIA+R+  T+   
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKV--------RLPALHIAARKDDTKSAA 209

Query: 487 LLLNRG--------ALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           LLL            +++R   +G  PLH+AA  G      LL +     +D   ++G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGIT 268

Query: 538 SLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            LH+A+     + + LLL  G ++     D
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 3/146 (2%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           TK  ++    A++ G+ D  + L L + + + +    G T+ H A+  +  N+   +  +
Sbjct: 659 TKQGVTPLHLASQEGHTD-MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D +A    G TPL VA     +  + +LL+Q    +   +    P+H A +     ++
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHII 777

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFA 155
            V  ++ +  N      +G TAL  A
Sbjct: 778 NVLLQHGAKPNATTA--NGNTALAIA 801


>X56958-1|CAA40279.2| 1872|Homo sapiens ankyrin (brank-2) protein.
          Length = 1872

 Score =  175 bits (425), Expect = 1e-42
 Identities = 140/548 (25%), Positives = 246/548 (44%), Gaps = 35/548 (6%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F++AA +GN+D  +  YL     +   +  G  A H A+   +  ++  +      +++ 
Sbjct: 35  FLRAARAGNLDKVVE-YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+++    +  ++    P++MA + N + V++   +  
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  N +   E G T L  A    H+    IL+  D   + + P       +H AA+   +
Sbjct: 154 A--NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA------LHIAARKDDT 205

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           ++  + LQ         + M++     G  PLH A H G++    L L  GA +     +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H+A  +G  ++VKL+      ++   + +     +TP+HCAA   H ++V  L+ 
Sbjct: 266 GITPLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
            G+ +    K   SPL +AA       V  L++  A +    ++    LH+         
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV--------- 371

Query: 376 DFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
             AA C  +   K LL      N +   G +PLH A ++  I+ +E L++ GA I     
Sbjct: 372 --AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
           +  +P+H AA  G  +    LL +     + N     G T LH+A+R G   VV  LL  
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI---RGETALHMAARAGQVEVVRCLLRN 486

Query: 492 GALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GAL+  R    + PLH+A+  G T+ ++LL    +H  D    +G T LH++  E +   
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH-PDAATTNGYTPLHISAREGQVDV 545

Query: 551 IALLLSMG 558
            ++LL  G
Sbjct: 546 ASVLLEAG 553



 Score =  167 bits (405), Expect = 3e-40
 Identities = 150/547 (27%), Positives = 239/547 (43%), Gaps = 35/547 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GNV+    L L+  + +      G T  H AS R NTN++  + +  G ++AK   
Sbjct: 240 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  +     +E LL++        +   +P+HMA + + V  ++   ++K+  
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-- 356

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            V+       TALH AA   H    K+L+ D  A       NG+ P+H A K    + +E
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVME 415

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +++G          I      G  P+H A   G +  V L L++GA          T 
Sbjct: 416 LLVKYGAS--------IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 467

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G +++V+ +         A + +   ++ TP+H A+     EIV  L+   + 
Sbjct: 468 LHMAARAGQVEVVRCLL-----RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
            +       +PL ++A          L+  GA   L        LH+    G    D A 
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL--DVA- 579

Query: 380 SCKDHCEKSLLQLLNEKDN---TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  K LLQ     D+    G +PLH A+   + +    L+  GA  +    N  +P
Sbjct: 580 -------KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH AA+  +   A  LL+    T I+ +   +G+TPLH+AS+EGHT +V LLL++GA +H
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 497 RD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
               +G   LHLAA        ++L + H    D   K G T L +A        +  LL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL-TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 556 SMGCRLS 562
             G  ++
Sbjct: 749 KQGANVN 755



 Score =  138 bits (334), Expect = 1e-31
 Identities = 114/476 (23%), Positives = 199/476 (41%), Gaps = 27/476 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NA+   G TPLH+A +   +  +E L++       
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  ++++ +  +  +  +V      G TALH AA        + L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN--IRGETALHMAARAGQVEVVRCLL 484

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            +  A           P+H A++   +  +++ LQ                   G  PLH
Sbjct: 485 RN-GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT--------TNGYTPLH 535

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G +    + L +GA  S       TP+H+A   G+LD+ KL+      ++ A   
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAAD 590

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           S     +TP+H AA +D+ ++   L+ +G+  +   K   +PL +AA +   +   TL+ 
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GA+  +        LHL    G    D      D         ++    +G + LH A+
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHT--DMVTLLLDKGAN-----IHMSTKSGLTSLHLAA 703

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   + L + GA  +       +PL  A  YG       LL        +N     
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKN 760

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL  GA  +    NG   L +A   GY   ++ L  V
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 816



 Score =  132 bits (320), Expect = 5e-30
 Identities = 121/458 (26%), Positives = 192/458 (41%), Gaps = 26/458 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L + +    R   G T  H A  +N   ++  +  Y   + A   +G TP+HVA   
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             L+ +  LLQ      V N + +  +HMA    +V V++   +  +L +     E  +T
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE--QT 499

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH A+        ++L+  + A       NGY P+H +A+        V L+ G     
Sbjct: 500 PLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-- 556

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                 SL   +G  PLH A   G +   +L L+  A   +   +  TP+H+A       
Sbjct: 557 ------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           +  L+      EK A   +      TP+H AA  +  +I + L+N G++ N + K+  +P
Sbjct: 611 VALLLL-----EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L LA+       V  L+  GA+I +   +    LHL        ED         +    
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-----EDKVNVADILTKHGAD 720

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
           Q  + K   G +PL  A   G+++ +  L++ GA +N K  N  +PLH AA+ G  H   
Sbjct: 721 QDAHTK--LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIIN 778

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
            LL         N +   G T L IA R G+  VV  L
Sbjct: 779 VLLQHGAKP---NATTANGNTALAIAKRLGYISVVDTL 813



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 67/251 (26%), Positives = 108/251 (43%), Gaps = 24/251 (9%)

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG--GRLEDFAA 379
           P   +  +  L AA       V   ++ G DI   + N  N LHL    G  G +++   
Sbjct: 26  PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
                   S +    +K NT    LH AS  G    ++ L++ GA IN ++ N  +PL+ 
Sbjct: 86  ------RGSSVDSATKKGNTA---LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 136

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+         LL++        E   +G TPL +A ++GH + V +LL       +  
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDT---KGK 190

Query: 500 NGRNPLHLAAMSGYTKTIELL----HS--VHSHLL-DQIDKDGNTSLHLATMENKPSSIA 552
                LH+AA    TK+  LL    H+  V S ++ ++  + G T LH+A      +   
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 553 LLLSMGCRLSY 563
           LLL+ G  + +
Sbjct: 251 LLLNRGAAVDF 261



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 70/270 (25%), Positives = 115/270 (42%), Gaps = 27/270 (10%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           ++V YL   G DIN  ++   + L LAA       V  L+  G+ +          LH+ 
Sbjct: 46  KVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
            +  G+ E      K+         +N +   G +PL+ A++E HI  ++ L+  GA  +
Sbjct: 105 SL-AGQAEVVKVLVKEGAN------INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSD-KGTFIINESDGEGLTPLHIASREGHTRVVH 486
               +  +PL  A + G       LL++D KG           L  LHIA+R+  T+   
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKV--------RLPALHIAARKDDTKSAA 209

Query: 487 LLLNRG--------ALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           LLL            +++R   +G  PLH+AA  G      LL +     +D   ++G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGIT 268

Query: 538 SLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            LH+A+     + + LLL  G ++     D
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 3/146 (2%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           TK  ++    A++ G+ D  + L L + + + +    G T+ H A+  +  N+   +  +
Sbjct: 659 TKQGVTPLHLASQEGHTD-MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D +A    G TPL VA     +  + +LL+Q    +   +    P+H A +     ++
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHII 777

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFA 155
            V  ++ +  N      +G TAL  A
Sbjct: 778 NVLLQHGAKPNATTA--NGNTALAIA 801


>BX537758-1|CAD97827.1| 1863|Homo sapiens hypothetical protein
           protein.
          Length = 1863

 Score =  175 bits (425), Expect = 1e-42
 Identities = 140/548 (25%), Positives = 246/548 (44%), Gaps = 35/548 (6%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F++AA +GN+D  +  YL     +   +  G  A H A+   +  ++  +      +++ 
Sbjct: 14  FLRAARAGNLDKVVE-YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+++    +  ++    P++MA + N + V++   +  
Sbjct: 73  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  N +   E G T L  A    H+    IL+  D   + + P       +H AA+   +
Sbjct: 133 A--NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA------LHIAARKDDT 184

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           ++  + LQ         + M++     G  PLH A H G++    L L  GA +     +
Sbjct: 185 KSAALLLQNDHNADIQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 244

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H+A  +G  ++VKL+      ++   + +     +TP+HCAA   H ++V  L+ 
Sbjct: 245 GITPLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
            G+ +    K   SPL +AA       V  L++  A +    ++    LH+         
Sbjct: 300 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV--------- 350

Query: 376 DFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
             AA C  +   K LL      N +   G +PLH A ++  I+ +E L++ GA I     
Sbjct: 351 --AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
           +  +P+H AA  G  +    LL +     + N     G T LH+A+R G   VV  LL  
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI---RGETALHMAARAGQVEVVRCLLRN 465

Query: 492 GALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GAL+  R    + PLH+A+  G T+ ++LL    +H  D    +G T LH++  E +   
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH-PDAATTNGYTPLHISAREGQVDV 524

Query: 551 IALLLSMG 558
            ++LL  G
Sbjct: 525 ASVLLEAG 532



 Score =  167 bits (405), Expect = 3e-40
 Identities = 150/547 (27%), Positives = 239/547 (43%), Gaps = 35/547 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GNV+    L L+  + +      G T  H AS R NTN++  + +  G ++AK   
Sbjct: 219 AAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  +     +E LL++        +   +P+HMA + + V  ++   ++K+  
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-- 335

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            V+       TALH AA   H    K+L+ D  A       NG+ P+H A K    + +E
Sbjct: 336 PVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVME 394

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +++G          I      G  P+H A   G +  V L L++GA          T 
Sbjct: 395 LLVKYGAS--------IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 446

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G +++V+ +         A + +   ++ TP+H A+     EIV  L+   + 
Sbjct: 447 LHMAARAGQVEVVRCLL-----RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
            +       +PL ++A          L+  GA   L        LH+    G    D A 
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL--DVA- 558

Query: 380 SCKDHCEKSLLQLLNEKDN---TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  K LLQ     D+    G +PLH A+   + +    L+  GA  +    N  +P
Sbjct: 559 -------KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 611

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH AA+  +   A  LL+    T I+ +   +G+TPLH+AS+EGHT +V LLL++GA +H
Sbjct: 612 LHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 497 RD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
               +G   LHLAA        ++L + H    D   K G T L +A        +  LL
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADIL-TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727

Query: 556 SMGCRLS 562
             G  ++
Sbjct: 728 KQGANVN 734



 Score =  138 bits (334), Expect = 1e-31
 Identities = 114/476 (23%), Positives = 199/476 (41%), Gaps = 27/476 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NA+   G TPLH+A +   +  +E L++       
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  ++++ +  +  +  +V      G TALH AA        + L+
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN--IRGETALHMAARAGQVEVVRCLL 463

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            +  A           P+H A++   +  +++ LQ                   G  PLH
Sbjct: 464 RN-GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT--------TNGYTPLH 514

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G +    + L +GA  S       TP+H+A   G+LD+ KL+      ++ A   
Sbjct: 515 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAAD 569

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           S     +TP+H AA +D+ ++   L+ +G+  +   K   +PL +AA +   +   TL+ 
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GA+  +        LHL    G    D      D         ++    +G + LH A+
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHT--DMVTLLLDKGAN-----IHMSTKSGLTSLHLAA 682

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   + L + GA  +       +PL  A  YG       LL        +N     
Sbjct: 683 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKN 739

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL  GA  +    NG   L +A   GY   ++ L  V
Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV 795



 Score =  132 bits (320), Expect = 5e-30
 Identities = 121/458 (26%), Positives = 192/458 (41%), Gaps = 26/458 (5%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           +L L + +    R   G T  H A  +N   ++  +  Y   + A   +G TP+HVA   
Sbjct: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRT 150
             L+ +  LLQ      V N + +  +HMA    +V V++   +  +L +     E  +T
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE--QT 478

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH A+        ++L+  + A       NGY P+H +A+        V L+ G     
Sbjct: 479 PLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-- 535

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD 270
                 SL   +G  PLH A   G +   +L L+  A   +   +  TP+H+A       
Sbjct: 536 ------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           +  L+      EK A   +      TP+H AA  +  +I + L+N G++ N + K+  +P
Sbjct: 590 VALLLL-----EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L LA+       V  L+  GA+I +   +    LHL        ED         +    
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-----EDKVNVADILTKHGAD 699

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
           Q  + K   G +PL  A   G+++ +  L++ GA +N K  N  +PLH AA+ G  H   
Sbjct: 700 QDAHTK--LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIIN 757

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
            LL         N +   G T L IA R G+  VV  L
Sbjct: 758 VLLQHGAKP---NATTANGNTALAIAKRLGYISVVDTL 792



 Score = 68.5 bits (160), Expect = 1e-10
 Identities = 69/251 (27%), Positives = 111/251 (44%), Gaps = 25/251 (9%)

Query: 323 LDKERRSPLLLAASRAG-WRTVHTLIRLGADIQLKDINSRNVLHLVVMNG--GRLEDFAA 379
           L K   +   L A+RAG    V   ++ G DI   + N  N LHL    G  G +++   
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
                   S +    +K NT    LH AS  G    ++ L++ GA IN ++ N  +PL+ 
Sbjct: 65  ------RGSSVDSATKKGNTA---LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 115

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+         LL++        E   +G TPL +A ++GH + V +LL       +  
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDT---KGK 169

Query: 500 NGRNPLHLAAMSGYTKTIELL----HS--VHSHLL-DQIDKDGNTSLHLATMENKPSSIA 552
                LH+AA    TK+  LL    H+  + S ++ ++  + G T LH+A      +   
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADIQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 553 LLLSMGCRLSY 563
           LLL+ G  + +
Sbjct: 230 LLLNRGAAVDF 240



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 70/270 (25%), Positives = 115/270 (42%), Gaps = 27/270 (10%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           ++V YL   G DIN  ++   + L LAA       V  L+  G+ +          LH+ 
Sbjct: 25  KVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 83

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
            +  G+ E      K+         +N +   G +PL+ A++E HI  ++ L+  GA  +
Sbjct: 84  SL-AGQAEVVKVLVKEGAN------INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSD-KGTFIINESDGEGLTPLHIASREGHTRVVH 486
               +  +PL  A + G       LL++D KG           L  LHIA+R+  T+   
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKV--------RLPALHIAARKDDTKSAA 188

Query: 487 LLLNRG--------ALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           LLL            +++R   +G  PLH+AA  G      LL +     +D   ++G T
Sbjct: 189 LLLQNDHNADIQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGIT 247

Query: 538 SLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            LH+A+     + + LLL  G ++     D
Sbjct: 248 PLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 3/146 (2%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           TK  ++    A++ G+ D  + L L + + + +    G T+ H A+  +  N+   +  +
Sbjct: 638 TKQGVTPLHLASQEGHTD-MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D +A    G TPL VA     +  + +LL+Q    +   +    P+H A +     ++
Sbjct: 697 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHII 756

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFA 155
            V  ++ +  N      +G TAL  A
Sbjct: 757 NVLLQHGAKPNATTA--NGNTALAIA 780


>AK097086-1|BAC04946.1|  919|Homo sapiens protein ( Homo sapiens
           cDNA FLJ39767 fis, clone SPLEN2000607, weakly similar to
           ANKYRIN 1. ).
          Length = 919

 Score =  171 bits (417), Expect = 9e-42
 Identities = 152/564 (26%), Positives = 255/564 (45%), Gaps = 48/564 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+V+  + L L++ + +   D + R A H A+   + +++  + N+  ++  KD  
Sbjct: 122 AALNGHVE-MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  N  ++ +++LL   VE   +N      +H+A    + +V+     Y +  
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA-- 238

Query: 140 NVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVNQ   +G T LHFAA   H  LC ++L+ +  A+      +G  P+H  A +      
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRS 297

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  +Q G +  C         D +GN PLH A   G    +     SGA  +        
Sbjct: 298 QTLIQNGGEIDCV--------DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMF 349

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           P+HLA      D  + + +   +     + + D    T +H AA   + E +  L + G+
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFE-----IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG-GRLEDF 377
           D +  DK  R+PL  AA+   +  + TL+  GA++   D   R  LH    +   R +  
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464

Query: 378 AASCKDHCEK-SLLQLLNEKDNTGC-------------------SPLHYASREGHIRSLE 417
             +  D+ E+    + L EK+ T C                   + +HYA+  GH + LE
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524

Query: 418 NLI-RLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
            L+ R  +     ++   +SPLH AA Y   H A ++L   +    ++  D +G T L +
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAA-YNGHHQALEVL--LQSLVDLDIRDEKGRTALDL 581

Query: 476 ASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAAMSGYTKTIELLHSV--HSHLLDQI 531
           A+ +GHT  V  L+N GA +    N   R PLH + ++G+T  + LL  +  +   +D  
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641

Query: 532 DKDGNTSLHLATMENKPSSIALLL 555
           D  G T L LA       +++LLL
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLL 665



 Score =  153 bits (371), Expect = 4e-36
 Identities = 130/485 (26%), Positives = 219/485 (45%), Gaps = 29/485 (5%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D+N  D+   TPLHVA      + IE L+      +  +     P+H A        +QV
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
             K+ +  +VN   ++ +T LH AA +    CA+++I  L +        G   +H AA 
Sbjct: 68  LIKHSA--DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAAL 124

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
           N     + + L  G          I+ +D +    LH A + G +  V L +  GA+++ 
Sbjct: 125 NGHVEMVNLLLAKGAN--------INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN 311
           +     TP+H A + G +++VK +  +  +     +   +V   T +H A       +VN
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVE-----IDEINVYGNTALHIACYNGQDAVVN 231

Query: 312 YLINEGSDINPLDKERRSPL-LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMN 370
            LI+ G+++N  +    +PL   AAS  G   +  L+  GAD+ ++  + ++ LH+  ++
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVH 291

Query: 371 GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
            GR        ++  E      ++  D  G +PLH A+R GH   +  L   GA      
Sbjct: 292 -GRFTRSQTLIQNGGE------IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            ++  PLH AA         +LL S    F I+  D  G T LH A+  G+   + LL +
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSG---FEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA  H +D  GR PLH AA + +   IE L +  ++ +++ D  G T+LH A   +   
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASDMDR 460

Query: 550 SIALL 554
           +  +L
Sbjct: 461 NKTIL 465



 Score =  151 bits (365), Expect = 2e-35
 Identities = 130/487 (26%), Positives = 205/487 (42%), Gaps = 32/487 (6%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D   RT  H A+   +  I+  +      +NAKDN   TPLH AV + + +A++ L++  
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 104 VETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC 163
            + +  ++  Q P+H+A     V   +V     S  NV+  G  GRTALH AA++ H   
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG--GRTALHHAALNGHVEM 130

Query: 164 AKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
             +L+    A            +H AA       + + +  G +  C         D +G
Sbjct: 131 VNLLLAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--------DKKG 181

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEK 283
             PLH+A   G I  V+  L  G +I       +T +H+AC  G   +V  +      + 
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI-----DY 236

Query: 284 HACLTSCDVQKMTPIHCAAMFDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
            A +   +    TP+H AA   H  + +  L+N G+D+N   K+ +SPL + A    +  
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHCEKSLLQLLNEKDNTG 400
             TLI+ G +I   D +    LH+    G  L       S  D  +  +  +        
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMF------- 349

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
             PLH A+   H      L+  G  I+  +    + LH AA  G      +LL S    F
Sbjct: 350 --PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQSSGADF 406

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIEL 519
             ++ D  G TPLH A+   H   +  L+  GA ++  D  GR  LH AA S   +   +
Sbjct: 407 --HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464

Query: 520 LHSVHSH 526
           L + H +
Sbjct: 465 LGNAHDN 471



 Score =  137 bits (331), Expect = 2e-31
 Identities = 140/573 (24%), Positives = 238/573 (41%), Gaps = 59/573 (10%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +   ++ +++ +   + +  RD   +T  H A+A         I      +N  D  G
Sbjct: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            T LH A  N  ++ +  LL +    +  ++K +  +H A  +  + V+ +   + +   
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA--E 173

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           V    + G T LH AA +      K L+ +L  E  +    G   +H A  N     +  
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNE 232

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLH---SAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            + +G          ++  +N G  PLH   ++ HG     +EL + +GA ++ Q  D  
Sbjct: 233 LIDYGAN--------VNQPNNNGFTPLHFAAASTHGA--LCLELLVNNGADVNIQSKDGK 282

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           +P+H+    G     +    +Q   +  C+   D    TP+H AA + H  ++N L   G
Sbjct: 283 SPLHMTAVHGR--FTRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTLRTSG 337

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           +D          PL LAA  A       L+  G +I   D   R  LH     GG +E  
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAA-GGNVE-- 394

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
              C    + S     ++KD  G +PLHYA+   H   +E L+  GA +N  ++   + L
Sbjct: 395 ---CIKLLQSSGAD-FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450

Query: 438 HFAAR---------YGRFHTACQLLDSDKG----------TFIINES------DGEGLTP 472
           H+AA           G  H   + L+  +            F++         D EG   
Sbjct: 451 HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510

Query: 473 LHIASREGHTRVVHLLLNR-GALLHRDHNG--RNPLHLAAMSGYTKTIE-LLHSVHSHLL 528
           +H A+  GH + + LLL R  +      +G  ++PLHLAA +G+ + +E LL S+    L
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVD--L 568

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           D  D+ G T+L LA  +     +  L++ G  +
Sbjct: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASI 601



 Score =  136 bits (328), Expect = 6e-31
 Identities = 137/533 (25%), Positives = 223/533 (41%), Gaps = 40/533 (7%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + + L +   +R+  +D    T  H+A A  +   +  +  ++ D+NA+D    TPLHVA
Sbjct: 30  EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVA 89

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             N+A+   E ++      +V +   +  +H A     V ++ +     +  N+N   + 
Sbjct: 90  AANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA--NINAFDKK 147

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
            R ALH+AA   H L    L+ +  AE       GY P+H AA N     ++  L  G  
Sbjct: 148 DRRALHWAAYMGH-LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG-- 204

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA-- 265
                   I++Y   GN  LH A + G    V   +  GA ++   ++  TP+H A A  
Sbjct: 205 ---VEIDEINVY---GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
            GAL +  L+         A +        +P+H  A+         LI  G +I+ +DK
Sbjct: 259 HGALCLELLV------NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHC 385
           +  +PL +AA       ++TL   GAD     I+S   LHL  +N         +  D C
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN---------AHSDCC 363

Query: 386 EKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARY 443
            K L     ++  D  G + LH A+  G++  ++ L   GA  + K+    +PLH+AA  
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423

Query: 444 GRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN 503
             FH    L+ +      +NE+D  G T LH A+     R      N+  L +   N   
Sbjct: 424 CHFHCIETLVTTGAN---VNETDDWGRTALHYAAASDMDR------NKTILGNAHDNSEE 474

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQI-DKDGNTSLHLATMENKPSSIALLL 555
                 +     T+ L   + +     I DK+G  S+H A        + LLL
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527



 Score =  130 bits (315), Expect = 2e-29
 Identities = 138/563 (24%), Positives = 239/563 (42%), Gaps = 37/563 (6%)

Query: 1   STYIHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNT 60
           S+   + T  K   +    AA  GNV+  ++L  S  +    +D  GRT  H A+A  + 
Sbjct: 368 SSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426

Query: 61  NILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           + +  +     ++N  D+ G T LH A  ++ +D  + +L    + S   E+ +      
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTILGNAHDNSEELERARELKEKE 485

Query: 121 TELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN 180
             L    +LQ  A      N +   + G  ++H+AA + H  C ++L+   ++ +++  +
Sbjct: 486 ATLCLEFLLQNDA------NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539

Query: 181 NG-YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
                P+H AA N   + +EV LQ            + + D +G   L  A   G  + V
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQ--------SLVDLDIRDEKGRTALDLAAFKGHTECV 591

Query: 240 ELCLRSGAKISTQQH-DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPI 298
           E  +  GA I  + +    TP+H +   G    ++L+  ++  +    +   D +  TP+
Sbjct: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL--LEIADNPEAVDVKDAKGQTPL 649

Query: 299 HCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDI 358
             A  + H + V+ L+ + ++++ +D    + L           V  L+     I  KD 
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709

Query: 359 NSRNVLHLVVMNG-----GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
             R  LH     G       L   A S +D C          KDN G +PLH+A   G+ 
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCC---------FKDNQGYTPLHWACYNGNE 760

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
             +E L+    C      N  +PLH A      + A  LL +   + I++  D +G TPL
Sbjct: 761 NCIEVLLE-QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSS-IVSCRDDKGRTPL 818

Query: 474 HIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
             A+   H   + LLL   A ++  D++G+  L +AA +G    +++L +     L   D
Sbjct: 819 RAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKD 878

Query: 533 KDGNTSLHLATMENKPSSIALLL 555
           KD NT LHLA  +       L+L
Sbjct: 879 KDLNTPLHLACSKGHEKCALLIL 901



 Score =  107 bits (258), Expect = 2e-22
 Identities = 80/283 (28%), Positives = 128/283 (45%), Gaps = 13/283 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           + + D +K TP+H AA     EI+  LI  G+ +N  D    +PL  A +      V  L
Sbjct: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           I+  AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+
Sbjct: 69  IKHSADVNARDKNWQTPLHVAAANK------AVKCAE-VIIPLLSSVNVSDRGGRTALHH 121

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+  GH+  +  L+  GA IN  +  +   LH+AA  G       L++       +   D
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE---VTCKD 178

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHS 525
            +G TPLH A+  G   VV  LLN G  +   +  G   LH+A  +G    +  L    +
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 526 HLLDQIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           + ++Q + +G T LH A      +  + LL++ G  ++  + D
Sbjct: 239 N-VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 280



 Score =  101 bits (242), Expect = 2e-20
 Identities = 80/264 (30%), Positives = 125/264 (47%), Gaps = 13/264 (4%)

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           LI++  D+N LD E+R+PL +AA       +  LI  GA +  KD      LH  V    
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV--AS 59

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           R E+       H        +N +D    +PLH A+    ++  E +I L + +N+ +  
Sbjct: 60  RSEEAVQVLIKHSAD-----VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             + LH AA  G       LL   KG   IN  D +    LH A+  GH  VV LL+N G
Sbjct: 115 GRTALHHAALNGHVEMVNLLL--AKGA-NINAFDKKDRRALHWAAYMGHLDVVALLINHG 171

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A +  +D  G  PLH AA +G    ++ L ++    +D+I+  GNT+LH+A    + + +
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE-IDEINVYGNTALHIACYNGQDAVV 230

Query: 552 ALLLSMGCRLSY-NNMDMSAIDYA 574
             L+  G  ++  NN   + + +A
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFA 254



 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 104/447 (23%), Positives = 175/447 (39%), Gaps = 32/447 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFI--NNYAGDLNAKDNAGNTPLHVA 87
           +   L   +  ++RD  G  + H A+A  +   L  +     +G   +   A  +PLH+A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             N    A+E LLQ  V+  + +EK +  + +A        ++      +   V      
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAKNASSRTIEVFLQWG 205
            RT LH + I+ H LC ++L+   D        +  G  P+  A        + + L+  
Sbjct: 610 -RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLE-- 666

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                 +E  +   D  G   LH  +  G  + V++ L     I  +     TP+H A A
Sbjct: 667 ------KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G    +  +  M   E+  C    D Q  TP+H A    +   +  L+ E         
Sbjct: 721 RGHATWLSELLQMALSEEDCCFK--DNQGYTPLHWACYNGNENCIEVLL-EQKCFRKFIG 777

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHC 385
              +PL  A           L  LGA I    ++ R+       + GR    AA+  DH 
Sbjct: 778 NPFTPLHCAIINDHGNCASLL--LGA-IDSSIVSCRD-------DKGRTPLRAAAFADHV 827

Query: 386 EKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHF 439
           E   L L     +N  DN+G + L  A+  G   +++ L+    A + +K+ +  +PLH 
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887

Query: 440 AARYGRFHTACQLLDSDKGTFIINESD 466
           A   G    A  +LD  +   +INE +
Sbjct: 888 ACSKGHEKCALLILDKIQDESLINEKN 914



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 63/298 (21%), Positives = 128/298 (42%), Gaps = 21/298 (7%)

Query: 37  PSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAI 96
           P  + V+D +G+T    A A  + + +  +     +++  D  G T LH  +     + +
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVS----VLQV-FAKYKSLFNVNQGGEHGRTA 151
           + LL+Q V     + + + P+H A      +    +LQ+  ++    F  NQ    G T 
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ----GYTP 750

Query: 152 LHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCT 211
           LH+A  + ++ C ++L+      ++K   N + P+H A  N       + L      G  
Sbjct: 751 LHWACYNGNENCIEVLLE--QKCFRKFIGNPFTPLHCAIINDHGNCASLLL------GAI 802

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
              ++S  D++G  PL +A     ++ ++L LR  A ++   +   T + +A   G    
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 862

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           V ++         A LT  D    TP+H A    H +    ++++  D + ++++  +
Sbjct: 863 VDILV----NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNA 916


>AK126888-1|BAC86737.1|  687|Homo sapiens protein ( Homo sapiens
           cDNA FLJ44940 fis, clone BRAMY4000915, weakly  similar
           to Ankyrin 1. ).
          Length = 687

 Score =  164 bits (398), Expect = 2e-39
 Identities = 142/531 (26%), Positives = 240/531 (45%), Gaps = 41/531 (7%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S +   +    AA SG+  + ++L LS  + +   D + R A H A+   +  ++ 
Sbjct: 165 NVNVSDRAGRTALHHAAFSGH-GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + ++  ++  KD    TPLH A  +  +  ++YLL   V+ +  N     P+H+A    
Sbjct: 224 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 283

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGY 183
           +  V+       ++  VNQ  E G T LHFAA   H  LC ++L+ +  A+      +G 
Sbjct: 284 QDVVVNELIDCGAI--VNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGK 340

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H  A +      +  +Q G    C         D  GN PLH A   G    +   +
Sbjct: 341 TPLHMTALHGRFSRSQTIIQSGAVIDCE--------DKNGNTPLHIAARYGHELLINTLI 392

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
            SGA  + +      P+HLA   G  D  + + +         + + D    T +H AA 
Sbjct: 393 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-----SGFDIDTPDDFGRTCLHAAAA 447

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
             + E +N L+N G+D N  DK  RSPL  AA+   ++ +  L+  GA +   D      
Sbjct: 448 GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTP 507

Query: 364 LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH------IRS-- 415
           LH    +     D    C ++  ++       +D  G + +HY++  GH      I S  
Sbjct: 508 LHYAATS-----DTDGKCLEYLLRNDANP-GVRDKQGYNAVHYSAAYGHRLCLQLIASET 561

Query: 416 -LENLIRLGACINLKNNNNE---SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
            L+ L+       L +++N    SPLH AA +G  H A ++L        +  S G   T
Sbjct: 562 PLDVLMETSGTDMLSDSDNRATISPLHLAAYHGH-HQALEVLVQSLLDLDVRNSSGR--T 618

Query: 472 PLHIASREGHTRVVHLLLNRGA-LLHRDH-NGRNPLHLAAMSGYTKTIELL 520
           PL +A+ +GH   V +L+N+GA +L +D+   R P+H AA +G+++ + LL
Sbjct: 619 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 669



 Score =  154 bits (374), Expect = 2e-36
 Identities = 122/431 (28%), Positives = 199/431 (46%), Gaps = 31/431 (7%)

Query: 140 NVNQGGEHGRTALHFAA-IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           +VN      RT LH AA + D ++   ++++      K   +    P+H A  + S   +
Sbjct: 66  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD--SKWLTPLHRAVASCSEEAV 123

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +V L+            ++  D     PLH A     +K  E  +   + ++       T
Sbjct: 124 QVLLKHSAD--------VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRT 175

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
            +H A   G  ++VKL+ +     + A + + D +    IH AA   H E+V  L++ G+
Sbjct: 176 ALHHAAFSGHGEMVKLLLS-----RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 230

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           ++   DK+  +PL  AAS      V  L+ LG D+   +      LH+   NG   +D  
Sbjct: 231 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG---QDVV 287

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH-IRSLENLIRLGACINLKNNNNESPL 437
            +    C      ++N+K+  G +PLH+A+   H    LE L+  GA +N+K+ + ++PL
Sbjct: 288 VNELIDCGA----IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 343

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLH 496
           H  A +GRF  +  ++ S     +I+  D  G TPLHIA+R GH  +++ L+  GA    
Sbjct: 344 HMTALHGRFSRSQTIIQSGA---VIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK 400

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
           R  +G  PLHLAA+SG++     L S     +D  D  G T LH A        + LLL+
Sbjct: 401 RGIHGMFPLHLAALSGFSDCCRKLLS-SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 459

Query: 557 MGCRLSYNNMD 567
            G    +N  D
Sbjct: 460 TGA--DFNKKD 468



 Score =  154 bits (373), Expect = 2e-36
 Identities = 147/548 (26%), Positives = 238/548 (43%), Gaps = 55/548 (10%)

Query: 7   STSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFI 66
           S +  V     VQA  +G+ D+ +R  + +   +  +D   RT  H A+   +  I+  +
Sbjct: 35  SGNVLVRYPSLVQAIFNGDPDE-VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93

Query: 67  NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
                 +NAKD+   TPLH AV + + +A++ LL+   + +  ++  Q P+H+A     V
Sbjct: 94  ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 153

Query: 127 SVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGY 183
              +  A    L NVN     GRTALH AA   H    K+L++   +++A  KK      
Sbjct: 154 KCAE--ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--- 208

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
             IH AA       +++ +  G +  C         D +   PLH+A   G I  V+  L
Sbjct: 209 -AIHWAAYMGHIEVVKLLVSHGAEVTCK--------DKKSYTPLHAAASSGMISVVKYLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             G  ++      +TP+H+AC  G   +V  +      +  A +   + +  TP+H AA 
Sbjct: 260 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHFAAA 314

Query: 304 FDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRN 362
             H  + +  L+  G+D+N   K+ ++PL + A    +    T+I+ GA I  +D N   
Sbjct: 315 STHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNT 374

Query: 363 VLHLVVMNGGRL---------EDFA---------------ASCKDHCEKSLLQ--LLNEK 396
            LH+    G  L          D A               +   D C K L     ++  
Sbjct: 375 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 434

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LH A+  G++  L  L+  GA  N K+    SPLH+AA    +     L+ S 
Sbjct: 435 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 494

Query: 457 KGTFIINESDGEGLTPLHIA--SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYT 514
                +N+ D  G TPLH A  S      + +LL N      RD  G N +H +A  G+ 
Sbjct: 495 AS---VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHR 551

Query: 515 KTIELLHS 522
             ++L+ S
Sbjct: 552 LCLQLIAS 559



 Score =  132 bits (319), Expect = 7e-30
 Identities = 99/351 (28%), Positives = 171/351 (48%), Gaps = 22/351 (6%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           +++ ++  DNE   PLH+A + GD + +EL + SGA+++ +     TP+H A A  + + 
Sbjct: 63  KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 122

Query: 272 VKLMFTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSP 330
           V+++       KH+  + + D    TP+H AA     +    L+   S++N  D+  R+ 
Sbjct: 123 VQVLL------KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 176

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L  AA       V  L+  GA+I   D   R  +H     G  +E          E +  
Sbjct: 177 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMG-HIEVVKLLVSHGAEVTC- 234

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
                KD    +PLH A+  G I  ++ L+ LG  +N  N    +PLH A   G+     
Sbjct: 235 -----KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVN 289

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRV-VHLLLNRGALLH-RDHNGRNPLHLA 508
           +L+D      I+N+ + +G TPLH A+   H  + + LL+  GA ++ +  +G+ PLH+ 
Sbjct: 290 ELIDCGA---IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 346

Query: 509 AMSG-YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           A+ G ++++  ++ S    ++D  DK+GNT LH+A        I  L++ G
Sbjct: 347 ALHGRFSRSQTIIQS--GAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 395



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 73/289 (25%), Positives = 122/289 (42%), Gaps = 12/289 (4%)

Query: 41  AVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLL 100
           A R   G    H A+    ++    + +   D++  D+ G T LH A     L+ +  LL
Sbjct: 399 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 458

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
               + +  ++  ++P+H A        L  FA   S  +VN   E G T LH+AA  D 
Sbjct: 459 NTGADFNKKDKFGRSPLHYAAANCNYQCL--FALVGSGASVNDLDERGCTPLHYAATSDT 516

Query: 161 D-LCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQ---WGEQRGCTREQMI 216
           D  C + L+ + DA        GY  +H +A       +++             +   M+
Sbjct: 517 DGKCLEYLLRN-DANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 575

Query: 217 SLYDNEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           S  DN   + PLH A + G  +A+E+ ++S   +  +     TP+ LA  +G ++ V ++
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 635

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                 +  + L    + K TPIH AA   H E +  LI      N +D
Sbjct: 636 IN----QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 680


>BC114476-1|AAI14477.1|  785|Homo sapiens ANKRD28 protein protein.
          Length = 785

 Score =  162 bits (393), Expect = 8e-39
 Identities = 154/595 (25%), Positives = 267/595 (44%), Gaps = 54/595 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S +   +    AA SG+  + ++L LS  + +   D + R A H A+   +  ++ 
Sbjct: 165 NVNVSDRAGRTALHHAAFSGH-GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + ++  ++  KD    TPLH A  +  +  ++YLL   V+ +  N     P+H+A    
Sbjct: 224 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 283

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGY 183
           +  V+       ++  VNQ  E G T LHFAA   H  LC ++L+ +  A+      +G 
Sbjct: 284 QDVVVNELIDCGAI--VNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGK 340

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H  A +      +  +Q G    C         D  GN PLH A   G    +   +
Sbjct: 341 TPLHMTALHGRFSRSQTIIQSGAVIDCE--------DKNGNTPLHIAARYGHELLINTLI 392

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTM-----QPKE-----KHA-------- 285
            SGA  + +      P+HLA   G  D  + + +       P +      HA        
Sbjct: 393 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 452

Query: 286 CL-----TSCDVQKM-----TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
           CL     T  D  K      +P+H AA   + + +  L+  G+ +N LD+   +PL  AA
Sbjct: 453 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 512

Query: 336 -SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHC--EKSLL 390
            S    + +  L+R  A+  ++D    N +H     G RL  +  A+        E S  
Sbjct: 513 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 572

Query: 391 QLLNEKDNTGC-SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
            +L++ DN    SPLH A+  GH ++LE L++    ++++N++  +PL  AA  G  H  
Sbjct: 573 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG--HVE 630

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN----RGALLHRDHNGRNPL 505
           C  +  ++G  I+ +      TP+H A+  GH+  + LL+     + A+  +D NG+ PL
Sbjct: 631 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPL 690

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            L+ ++G+T  +  L +  ++ +D  DK G T+LH   +      +  LL  G +
Sbjct: 691 MLSVLNGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 744



 Score =  154 bits (373), Expect = 2e-36
 Identities = 147/548 (26%), Positives = 238/548 (43%), Gaps = 55/548 (10%)

Query: 7   STSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFI 66
           S +  V     VQA  +G+ D+ +R  + +   +  +D   RT  H A+   +  I+  +
Sbjct: 35  SGNVLVRYPSLVQAIFNGDPDE-VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93

Query: 67  NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
                 +NAKD+   TPLH AV + + +A++ LL+   + +  ++  Q P+H+A     V
Sbjct: 94  ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 153

Query: 127 SVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGY 183
              +  A    L NVN     GRTALH AA   H    K+L++   +++A  KK      
Sbjct: 154 KCAE--ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--- 208

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
             IH AA       +++ +  G +  C         D +   PLH+A   G I  V+  L
Sbjct: 209 -AIHWAAYMGHIEVVKLLVSHGAEVTCK--------DKKSYTPLHAAASSGMISVVKYLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             G  ++      +TP+H+AC  G   +V  +      +  A +   + +  TP+H AA 
Sbjct: 260 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHFAAA 314

Query: 304 FDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRN 362
             H  + +  L+  G+D+N   K+ ++PL + A    +    T+I+ GA I  +D N   
Sbjct: 315 STHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNT 374

Query: 363 VLHLVVMNGGRL---------EDFA---------------ASCKDHCEKSLLQ--LLNEK 396
            LH+    G  L          D A               +   D C K L     ++  
Sbjct: 375 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 434

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LH A+  G++  L  L+  GA  N K+    SPLH+AA    +     L+ S 
Sbjct: 435 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 494

Query: 457 KGTFIINESDGEGLTPLHIA--SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYT 514
                +N+ D  G TPLH A  S      + +LL N      RD  G N +H +A  G+ 
Sbjct: 495 AS---VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 551

Query: 515 KTIELLHS 522
             ++L+ S
Sbjct: 552 LCLQLIAS 559



 Score =  134 bits (324), Expect = 2e-30
 Identities = 133/534 (24%), Positives = 236/534 (44%), Gaps = 40/534 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLH-VAVENEALDAIEYLLQQHVE 105
           G T  H A       +++ + +    +N K+  G TPLH  A        +E L+    +
Sbjct: 272 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 331

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            ++ ++  + P+HM     + S  Q   +  ++ +     ++G T LH AA + H+L   
Sbjct: 332 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED--KNGNTPLHIAARYGHELLIN 389

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            LIT   A+  K   +G +P+H AA +  S      L  G          I   D+ G  
Sbjct: 390 TLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD--------IDTPDDFGRT 440

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
            LH+A  GG+++ + L L +GA  + +     +P+H A A       + +F +      A
Sbjct: 441 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY---QCLFALVGSG--A 495

Query: 286 CLTSCDVQKMTPIHCAAMFDHP-EIVNYLINEGSDINPLDKERRSPLLLAASR------- 337
            +   D +  TP+H AA  D   + + YL+   ++    DK+  + +  +A+        
Sbjct: 496 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 555

Query: 338 --AGWRTVHTLIRLGADIQLKDINSR---NVLHLVVMNGGRLEDFAASCKDHCEKSLLQL 392
             A    +  L+       L D ++R   + LHL   +G           +   +SLL L
Sbjct: 556 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH------QALEVLVQSLLDL 609

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQ 451
            + ++++G +PL  A+ +GH+  ++ LI  GA I +K+     +P+H AA  G       
Sbjct: 610 -DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 668

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAM 510
           L+ + +    ++  DG G TPL ++   GHT  V+ LLN+GA +  +D  GR  LH  A+
Sbjct: 669 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAV 728

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           +G+ + ++ L    +  L + D  G T +HL+        +  LL     +  N
Sbjct: 729 TGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 781



 Score =  105 bits (253), Expect = 7e-22
 Identities = 94/360 (26%), Positives = 156/360 (43%), Gaps = 26/360 (7%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG   D  R  LS    +   D  GRT  H A+A  N   L+ + N   D N KD  
Sbjct: 412 AALSG-FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 470

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH-MATELNKVSVLQVFAKYKSL 138
           G +PLH A  N     +  L+      + L+E+   P+H  AT       L+   +  + 
Sbjct: 471 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA- 529

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILI--TDLD-------AEWKKPCNN--GYYPIH 187
            N     + G  A+H++A + H LC +++   T LD        +     +N     P+H
Sbjct: 530 -NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 588

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA +   + +EV +Q            + + ++ G  PL  A   G ++ V++ +  GA
Sbjct: 589 LAAYHGHHQALEVLVQ--------SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 640

Query: 248 KISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDH 306
            I  + + L  TP+H A   G  + ++L+  +   E    +   D    TP+  + +  H
Sbjct: 641 SILVKDYILKRTPIHAAATNGHSECLRLL--IGNAEPQNAVDIQDGNGQTPLMLSVLNGH 698

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            + V  L+N+G++++  DK  R+ L   A       V  L++ GA   L+D   R  +HL
Sbjct: 699 TDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 758



 Score =  103 bits (247), Expect = 4e-21
 Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 13/279 (4%)

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
           D +K TP+H AA     EI+  LI  G+ +N  D +  +PL  A +      V  L++  
Sbjct: 71  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 130

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+A+  
Sbjct: 131 ADVNARDKNWQTPLHIAAANK------AVKCAE-ALVPLLSNVNVSDRAGRTALHHAAFS 183

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH   ++ L+  GA IN  +  +   +H+AA  G      +LL S      +   D +  
Sbjct: 184 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV-KLLVSHGAE--VTCKDKKSY 240

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           TPLH A+  G   VV  LL+ G  ++  +  G  PLH+A  +G    +  L    + +++
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA-IVN 299

Query: 530 QIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           Q ++ G T LH A      +  + LL+  G  ++  + D
Sbjct: 300 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 338



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 23/267 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY---------A 70
           AA S      +   L   +   +RD +G  A H ++A  +   L  I +          +
Sbjct: 511 AATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETS 570

Query: 71  GD--LNAKDNAGN-TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVS 127
           G   L+  DN    +PLH+A  +    A+E L+Q  ++  V N   + P+ +A     V 
Sbjct: 571 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 630

Query: 128 VLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN--NGYYP 185
            + V     +   V       RT +H AA + H  C ++LI + + +        NG  P
Sbjct: 631 CVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 689

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +  +  N  +  +   L  G          +   D  G   LH     G  + V+  L+ 
Sbjct: 690 LMLSVLNGHTDCVYSLLNKGAN--------VDAKDKWGRTALHRGAVTGHEECVDALLQH 741

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIV 272
           GAK   +     TP+HL+ A G + ++
Sbjct: 742 GAKCLLRDSRGRTPIHLSAACGHIGVL 768



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 3/128 (2%)

Query: 18  VQAAESGNVDDFMRLYL--SEPSRLA-VRDGRGRTAAHQASARNNTNILHFINNYAGDLN 74
           + AA +    + +RL +  +EP     ++DG G+T    +    +T+ ++ + N   +++
Sbjct: 654 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 713

Query: 75  AKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           AKD  G T LH        + ++ LLQ   +  + + + + PIH++     + VL    +
Sbjct: 714 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 773

Query: 135 YKSLFNVN 142
             +  + N
Sbjct: 774 SAASMDAN 781


>BC113868-1|AAI13869.1|  782|Homo sapiens ANKRD28 protein protein.
          Length = 782

 Score =  162 bits (393), Expect = 8e-39
 Identities = 154/595 (25%), Positives = 267/595 (44%), Gaps = 54/595 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S +   +    AA SG+  + ++L LS  + +   D + R A H A+   +  ++ 
Sbjct: 162 NVNVSDRAGRTALHHAAFSGH-GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 220

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + ++  ++  KD    TPLH A  +  +  ++YLL   V+ +  N     P+H+A    
Sbjct: 221 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 280

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGY 183
           +  V+       ++  VNQ  E G T LHFAA   H  LC ++L+ +  A+      +G 
Sbjct: 281 QDVVVNELIDCGAI--VNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGK 337

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H  A +      +  +Q G    C         D  GN PLH A   G    +   +
Sbjct: 338 TPLHMTALHGRFSRSQTIIQSGAVIDCE--------DKNGNTPLHIAARYGHELLINTLI 389

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTM-----QPKE-----KHA-------- 285
            SGA  + +      P+HLA   G  D  + + +       P +      HA        
Sbjct: 390 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 449

Query: 286 CL-----TSCDVQKM-----TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
           CL     T  D  K      +P+H AA   + + +  L+  G+ +N LD+   +PL  AA
Sbjct: 450 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 509

Query: 336 -SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHC--EKSLL 390
            S    + +  L+R  A+  ++D    N +H     G RL  +  A+        E S  
Sbjct: 510 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 569

Query: 391 QLLNEKDNTGC-SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
            +L++ DN    SPLH A+  GH ++LE L++    ++++N++  +PL  AA  G  H  
Sbjct: 570 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG--HVE 627

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN----RGALLHRDHNGRNPL 505
           C  +  ++G  I+ +      TP+H A+  GH+  + LL+     + A+  +D NG+ PL
Sbjct: 628 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPL 687

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            L+ ++G+T  +  L +  ++ +D  DK G T+LH   +      +  LL  G +
Sbjct: 688 MLSVLNGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 741



 Score =  154 bits (374), Expect = 2e-36
 Identities = 149/551 (27%), Positives = 240/551 (43%), Gaps = 56/551 (10%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           +H   S  V L   VQA  +G+ D+ +R  + +   +  +D   RT  H A+   +  I+
Sbjct: 30  LHSPPSGNV-LPSLVQAIFNGDPDE-VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEII 87

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             +      +NAKD+   TPLH AV + + +A++ LL+   + +  ++  Q P+H+A   
Sbjct: 88  ELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAAN 147

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCN 180
             V   +  A    L NVN     GRTALH AA   H    K+L++   +++A  KK   
Sbjct: 148 KAVKCAE--ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR 205

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
                IH AA       +++ +  G +  C         D +   PLH+A   G I  V+
Sbjct: 206 ----AIHWAAYMGHIEVVKLLVSHGAEVTCK--------DKKSYTPLHAAASSGMISVVK 253

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             L  G  ++      +TP+H+AC  G   +V  +      +  A +   + +  TP+H 
Sbjct: 254 YLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHF 308

Query: 301 AAMFDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
           AA   H  + +  L+  G+D+N   K+ ++PL + A    +    T+I+ GA I  +D N
Sbjct: 309 AAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKN 368

Query: 360 SRNVLHLVVMNGGRL---------EDFA---------------ASCKDHCEKSLLQ--LL 393
               LH+    G  L          D A               +   D C K L     +
Sbjct: 369 GNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDI 428

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +  D+ G + LH A+  G++  L  L+  GA  N K+    SPLH+AA    +     L+
Sbjct: 429 DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALV 488

Query: 454 DSDKGTFIINESDGEGLTPLHIA--SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMS 511
            S      +N+ D  G TPLH A  S      + +LL N      RD  G N +H +A  
Sbjct: 489 GSGAS---VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAY 545

Query: 512 GYTKTIELLHS 522
           G+   ++L+ S
Sbjct: 546 GHRLCLQLIAS 556



 Score =  134 bits (324), Expect = 2e-30
 Identities = 133/534 (24%), Positives = 236/534 (44%), Gaps = 40/534 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLH-VAVENEALDAIEYLLQQHVE 105
           G T  H A       +++ + +    +N K+  G TPLH  A        +E L+    +
Sbjct: 269 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 328

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            ++ ++  + P+HM     + S  Q   +  ++ +     ++G T LH AA + H+L   
Sbjct: 329 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED--KNGNTPLHIAARYGHELLIN 386

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            LIT   A+  K   +G +P+H AA +  S      L  G          I   D+ G  
Sbjct: 387 TLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD--------IDTPDDFGRT 437

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
            LH+A  GG+++ + L L +GA  + +     +P+H A A       + +F +      A
Sbjct: 438 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY---QCLFALVGSG--A 492

Query: 286 CLTSCDVQKMTPIHCAAMFDHP-EIVNYLINEGSDINPLDKERRSPLLLAASR------- 337
            +   D +  TP+H AA  D   + + YL+   ++    DK+  + +  +A+        
Sbjct: 493 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 552

Query: 338 --AGWRTVHTLIRLGADIQLKDINSR---NVLHLVVMNGGRLEDFAASCKDHCEKSLLQL 392
             A    +  L+       L D ++R   + LHL   +G           +   +SLL L
Sbjct: 553 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH------QALEVLVQSLLDL 606

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQ 451
            + ++++G +PL  A+ +GH+  ++ LI  GA I +K+     +P+H AA  G       
Sbjct: 607 -DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 665

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAM 510
           L+ + +    ++  DG G TPL ++   GHT  V+ LLN+GA +  +D  GR  LH  A+
Sbjct: 666 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAV 725

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           +G+ + ++ L    +  L + D  G T +HL+        +  LL     +  N
Sbjct: 726 TGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 778



 Score =  105 bits (253), Expect = 7e-22
 Identities = 94/360 (26%), Positives = 156/360 (43%), Gaps = 26/360 (7%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG   D  R  LS    +   D  GRT  H A+A  N   L+ + N   D N KD  
Sbjct: 409 AALSG-FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 467

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH-MATELNKVSVLQVFAKYKSL 138
           G +PLH A  N     +  L+      + L+E+   P+H  AT       L+   +  + 
Sbjct: 468 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA- 526

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILI--TDLD-------AEWKKPCNN--GYYPIH 187
            N     + G  A+H++A + H LC +++   T LD        +     +N     P+H
Sbjct: 527 -NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 585

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA +   + +EV +Q            + + ++ G  PL  A   G ++ V++ +  GA
Sbjct: 586 LAAYHGHHQALEVLVQ--------SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 637

Query: 248 KISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDH 306
            I  + + L  TP+H A   G  + ++L+  +   E    +   D    TP+  + +  H
Sbjct: 638 SILVKDYILKRTPIHAAATNGHSECLRLL--IGNAEPQNAVDIQDGNGQTPLMLSVLNGH 695

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            + V  L+N+G++++  DK  R+ L   A       V  L++ GA   L+D   R  +HL
Sbjct: 696 TDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 755



 Score =  103 bits (247), Expect = 4e-21
 Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 13/279 (4%)

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
           D +K TP+H AA     EI+  LI  G+ +N  D +  +PL  A +      V  L++  
Sbjct: 68  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 127

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+A+  
Sbjct: 128 ADVNARDKNWQTPLHIAAANK------AVKCAE-ALVPLLSNVNVSDRAGRTALHHAAFS 180

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH   ++ L+  GA IN  +  +   +H+AA  G      +LL S      +   D +  
Sbjct: 181 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV-KLLVSHGAE--VTCKDKKSY 237

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           TPLH A+  G   VV  LL+ G  ++  +  G  PLH+A  +G    +  L    + +++
Sbjct: 238 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA-IVN 296

Query: 530 QIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           Q ++ G T LH A      +  + LL+  G  ++  + D
Sbjct: 297 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 335



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 23/267 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY---------A 70
           AA S      +   L   +   +RD +G  A H ++A  +   L  I +          +
Sbjct: 508 AATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETS 567

Query: 71  GD--LNAKDNAGN-TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVS 127
           G   L+  DN    +PLH+A  +    A+E L+Q  ++  V N   + P+ +A     V 
Sbjct: 568 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 627

Query: 128 VLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN--NGYYP 185
            + V     +   V       RT +H AA + H  C ++LI + + +        NG  P
Sbjct: 628 CVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 686

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +  +  N  +  +   L  G          +   D  G   LH     G  + V+  L+ 
Sbjct: 687 LMLSVLNGHTDCVYSLLNKGAN--------VDAKDKWGRTALHRGAVTGHEECVDALLQH 738

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIV 272
           GAK   +     TP+HL+ A G + ++
Sbjct: 739 GAKCLLRDSRGRTPIHLSAACGHIGVL 765



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 3/128 (2%)

Query: 18  VQAAESGNVDDFMRLYL--SEPSRLA-VRDGRGRTAAHQASARNNTNILHFINNYAGDLN 74
           + AA +    + +RL +  +EP     ++DG G+T    +    +T+ ++ + N   +++
Sbjct: 651 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 710

Query: 75  AKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           AKD  G T LH        + ++ LLQ   +  + + + + PIH++     + VL    +
Sbjct: 711 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 770

Query: 135 YKSLFNVN 142
             +  + N
Sbjct: 771 SAASMDAN 778


>BC106948-1|AAI06949.2|  785|Homo sapiens ANKRD28 protein protein.
          Length = 785

 Score =  162 bits (393), Expect = 8e-39
 Identities = 154/595 (25%), Positives = 267/595 (44%), Gaps = 54/595 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S +   +    AA SG+  + ++L LS  + +   D + R A H A+   +  ++ 
Sbjct: 165 NVNVSDRAGRTALHHAAFSGH-GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + ++  ++  KD    TPLH A  +  +  ++YLL   V+ +  N     P+H+A    
Sbjct: 224 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 283

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGY 183
           +  V+       ++  VNQ  E G T LHFAA   H  LC ++L+ +  A+      +G 
Sbjct: 284 QDVVVNELIDCGAI--VNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGK 340

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
            P+H  A +      +  +Q G    C         D  GN PLH A   G    +   +
Sbjct: 341 TPLHMTALHGRFSRSQTIIQSGAVIDCE--------DKNGNTPLHIAARYGHELLINTLI 392

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTM-----QPKE-----KHA-------- 285
            SGA  + +      P+HLA   G  D  + + +       P +      HA        
Sbjct: 393 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 452

Query: 286 CL-----TSCDVQKM-----TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
           CL     T  D  K      +P+H AA   + + +  L+  G+ +N LD+   +PL  AA
Sbjct: 453 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 512

Query: 336 -SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHC--EKSLL 390
            S    + +  L+R  A+  ++D    N +H     G RL  +  A+        E S  
Sbjct: 513 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 572

Query: 391 QLLNEKDNTGC-SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTA 449
            +L++ DN    SPLH A+  GH ++LE L++    ++++N++  +PL  AA  G  H  
Sbjct: 573 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG--HVE 630

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN----RGALLHRDHNGRNPL 505
           C  +  ++G  I+ +      TP+H A+  GH+  + LL+     + A+  +D NG+ PL
Sbjct: 631 CVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPL 690

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            L+ ++G+T  +  L +  ++ +D  DK G T+LH   +      +  LL  G +
Sbjct: 691 MLSVLNGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 744



 Score =  154 bits (373), Expect = 2e-36
 Identities = 147/548 (26%), Positives = 238/548 (43%), Gaps = 55/548 (10%)

Query: 7   STSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFI 66
           S +  V     VQA  +G+ D+ +R  + +   +  +D   RT  H A+   +  I+  +
Sbjct: 35  SGNVLVRYPSLVQAIFNGDPDE-VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93

Query: 67  NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
                 +NAKD+   TPLH AV + + +A++ LL+   + +  ++  Q P+H+A     V
Sbjct: 94  ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 153

Query: 127 SVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGY 183
              +  A    L NVN     GRTALH AA   H    K+L++   +++A  KK      
Sbjct: 154 KCAE--ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--- 208

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
             IH AA       +++ +  G +  C         D +   PLH+A   G I  V+  L
Sbjct: 209 -AIHWAAYMGHIEVVKLLVSHGAEVTCK--------DKKSYTPLHAAASSGMISVVKYLL 259

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             G  ++      +TP+H+AC  G   +V  +      +  A +   + +  TP+H AA 
Sbjct: 260 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-----DCGAIVNQKNEKGFTPLHFAAA 314

Query: 304 FDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRN 362
             H  + +  L+  G+D+N   K+ ++PL + A    +    T+I+ GA I  +D N   
Sbjct: 315 STHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNT 374

Query: 363 VLHLVVMNGGRL---------EDFA---------------ASCKDHCEKSLLQ--LLNEK 396
            LH+    G  L          D A               +   D C K L     ++  
Sbjct: 375 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 434

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LH A+  G++  L  L+  GA  N K+    SPLH+AA    +     L+ S 
Sbjct: 435 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 494

Query: 457 KGTFIINESDGEGLTPLHIA--SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYT 514
                +N+ D  G TPLH A  S      + +LL N      RD  G N +H +A  G+ 
Sbjct: 495 AS---VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 551

Query: 515 KTIELLHS 522
             ++L+ S
Sbjct: 552 LCLQLIAS 559



 Score =  134 bits (324), Expect = 2e-30
 Identities = 133/534 (24%), Positives = 236/534 (44%), Gaps = 40/534 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLH-VAVENEALDAIEYLLQQHVE 105
           G T  H A       +++ + +    +N K+  G TPLH  A        +E L+    +
Sbjct: 272 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 331

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            ++ ++  + P+HM     + S  Q   +  ++ +     ++G T LH AA + H+L   
Sbjct: 332 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED--KNGNTPLHIAARYGHELLIN 389

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            LIT   A+  K   +G +P+H AA +  S      L  G          I   D+ G  
Sbjct: 390 TLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD--------IDTPDDFGRT 440

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
            LH+A  GG+++ + L L +GA  + +     +P+H A A       + +F +      A
Sbjct: 441 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY---QCLFALVGSG--A 495

Query: 286 CLTSCDVQKMTPIHCAAMFDHP-EIVNYLINEGSDINPLDKERRSPLLLAASR------- 337
            +   D +  TP+H AA  D   + + YL+   ++    DK+  + +  +A+        
Sbjct: 496 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 555

Query: 338 --AGWRTVHTLIRLGADIQLKDINSR---NVLHLVVMNGGRLEDFAASCKDHCEKSLLQL 392
             A    +  L+       L D ++R   + LHL   +G           +   +SLL L
Sbjct: 556 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH------QALEVLVQSLLDL 609

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQ 451
            + ++++G +PL  A+ +GH+  ++ LI  GA I +K+     +P+H AA  G       
Sbjct: 610 -DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 668

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAM 510
           L+ + +    ++  DG G TPL ++   GHT  V+ LLN+GA +  +D  GR  LH  A+
Sbjct: 669 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAV 728

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           +G+ + ++ L    +  L + D  G T +HL+        +  LL     +  N
Sbjct: 729 TGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 781



 Score =  105 bits (253), Expect = 7e-22
 Identities = 94/360 (26%), Positives = 156/360 (43%), Gaps = 26/360 (7%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG   D  R  LS    +   D  GRT  H A+A  N   L+ + N   D N KD  
Sbjct: 412 AALSG-FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 470

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH-MATELNKVSVLQVFAKYKSL 138
           G +PLH A  N     +  L+      + L+E+   P+H  AT       L+   +  + 
Sbjct: 471 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA- 529

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILI--TDLD-------AEWKKPCNN--GYYPIH 187
            N     + G  A+H++A + H LC +++   T LD        +     +N     P+H
Sbjct: 530 -NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 588

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA +   + +EV +Q            + + ++ G  PL  A   G ++ V++ +  GA
Sbjct: 589 LAAYHGHHQALEVLVQ--------SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 640

Query: 248 KISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDH 306
            I  + + L  TP+H A   G  + ++L+  +   E    +   D    TP+  + +  H
Sbjct: 641 SILVKDYILKRTPIHAAATNGHSECLRLL--IGNAEPQNAVDIQDGNGQTPLMLSVLNGH 698

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            + V  L+N+G++++  DK  R+ L   A       V  L++ GA   L+D   R  +HL
Sbjct: 699 TDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 758



 Score =  103 bits (247), Expect = 4e-21
 Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 13/279 (4%)

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
           D +K TP+H AA     EI+  LI  G+ +N  D +  +PL  A +      V  L++  
Sbjct: 71  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 130

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+A+  
Sbjct: 131 ADVNARDKNWQTPLHIAAANK------AVKCAE-ALVPLLSNVNVSDRAGRTALHHAAFS 183

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH   ++ L+  GA IN  +  +   +H+AA  G      +LL S      +   D +  
Sbjct: 184 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV-KLLVSHGAE--VTCKDKKSY 240

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           TPLH A+  G   VV  LL+ G  ++  +  G  PLH+A  +G    +  L    + +++
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA-IVN 299

Query: 530 QIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           Q ++ G T LH A      +  + LL+  G  ++  + D
Sbjct: 300 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 338



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 23/267 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY---------A 70
           AA S      +   L   +   +RD +G  A H ++A  +   L  I +          +
Sbjct: 511 AATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETS 570

Query: 71  GD--LNAKDNAGN-TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVS 127
           G   L+  DN    +PLH+A  +    A+E L+Q  ++  V N   + P+ +A     V 
Sbjct: 571 GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVE 630

Query: 128 VLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN--NGYYP 185
            + V     +   V       RT +H AA + H  C ++LI + + +        NG  P
Sbjct: 631 CVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 689

Query: 186 IHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           +  +  N  +  +   L  G          +   D  G   LH     G  + V+  L+ 
Sbjct: 690 LMLSVLNGHTDCVYSLLNKGAN--------VDAKDKWGRTALHRGAVTGHEECVDALLQH 741

Query: 246 GAKISTQQHDLSTPVHLACAQGALDIV 272
           GAK   +     TP+HL+ A G + ++
Sbjct: 742 GAKCLLRDSRGRTPIHLSAACGHIGVL 768



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 3/128 (2%)

Query: 18  VQAAESGNVDDFMRLYL--SEPSRLA-VRDGRGRTAAHQASARNNTNILHFINNYAGDLN 74
           + AA +    + +RL +  +EP     ++DG G+T    +    +T+ ++ + N   +++
Sbjct: 654 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 713

Query: 75  AKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           AKD  G T LH        + ++ LLQ   +  + + + + PIH++     + VL    +
Sbjct: 714 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 773

Query: 135 YKSLFNVN 142
             +  + N
Sbjct: 774 SAASMDAN 781


>U13616-1|AAA64834.1| 4377|Homo sapiens ankyrin G protein.
          Length = 4377

 Score =  161 bits (392), Expect = 1e-38
 Identities = 135/536 (25%), Positives = 233/536 (43%), Gaps = 39/536 (7%)

Query: 38  SRLAVRDGRGRT---AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALD 94
           S L   D +G+    A H A+ +++T     +     + + +  +G TPLH+A     ++
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHF 154
               LL +             P+H+A++    +++++     +   ++     G T LH 
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA--KIDAKTRDGLTPLHC 307

Query: 155 AAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQ 214
            A   H+   ++L+ D  A       NG  P+H A +      +++ LQ           
Sbjct: 308 GARSGHEQVVEMLL-DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--------HNV 358

Query: 215 MISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
            +    N+    LH A H G  K  ++ L   A  + +  +  TP+H+AC +  + +++L
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418

Query: 275 MFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           +       KH A + +     +TPIH AA   H  IV+ L++ G+  N  +    + L +
Sbjct: 419 LL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL- 392
           AA       V  L++ GA ++ K  + +  LH+    G          K    + LLQ  
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----------KADIVQQLLQQG 522

Query: 393 --LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              N    +G +PLH ++REGH      L+  GA +++      +PLH AA+YG+   A 
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAA 509
            LL          +S   GLTPLH+A+   + +V  LLL++GA  H    NG  PLH+AA
Sbjct: 583 LLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
                     L    +   + + + G  S+HLA  E     ++LLL     ++ +N
Sbjct: 640 KKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694



 Score =  153 bits (370), Expect = 5e-36
 Identities = 129/537 (24%), Positives = 227/537 (42%), Gaps = 29/537 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ GN +  ++L L   +++  +   G T  H  +   +  ++  + + A  + +K   
Sbjct: 275 ASKRGNAN-MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G +PLH+A + + L+ ++ LLQ +V    +       +H+A       V +V    K+  
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA-- 391

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 451 QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 503 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 615

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 616 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AA+ G       LL  +     +N S+  GLTPLH+A++E    V  +L+N+GA +  + 
Sbjct: 671 AAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783



 Score =  152 bits (368), Expect = 8e-36
 Identities = 141/570 (24%), Positives = 238/570 (41%), Gaps = 34/570 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ G+V+    L L   + +     +G TA H AS      ++  +     ++NA+   
Sbjct: 81  ASKEGHVEVVSEL-LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL++A +   L+ +++LL      S+  E    P+ +A +     V+ +      L 
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL------LL 193

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             +  G+    ALH AA  D    A +L+ + D        +G+ P+H AA   +     
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVAT 252

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L         R   +         PLH A   G+   V+L L  GAKI  +  D  TP
Sbjct: 253 LLL--------NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H     G   +V+++      ++ A + S     ++P+H A   DH   V  L+     
Sbjct: 305 LHCGARSGHEQVVEMLL-----DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++ +  +  + L +AA    ++    L+   A+   K +N    LH +     R++    
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH-IACKKNRIKVMEL 418

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             K     + +Q + E   +G +P+H A+  GH+  +  L+  GA  N  N   E+ LH 
Sbjct: 419 LLK---HGASIQAVTE---SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AAR G+     + L  D         D +  TPLHI++R G   +V  LL +GA  +   
Sbjct: 473 AARSGQAEVV-RYLVQDGAQVEAKAKDDQ--TPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            +G  PLHL+A  G+      L   H   L    K G T LH+A    K     LLL   
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 559 CRL-SYNNMDMSAIDYAIYYKFPEAALAMV 587
               +     ++ +  A +Y   + AL ++
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618



 Score =  152 bits (368), Expect = 8e-36
 Identities = 118/476 (24%), Positives = 199/476 (41%), Gaps = 27/476 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NAK   G TPLH+A +   +  +E LL+       
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  V+++     + +  + N     G TALH AA        + L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGA--SPNTTNVRGETALHMAARSGQAEVVRYLV 486

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            D  A+ +    +   P+H +A+   +  ++  LQ G                 G  PLH
Sbjct: 487 QD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT--------TSGYTPLH 537

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G        L  GA +S       TP+H+A   G L++  L+      +K A   
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-----QKSASPD 592

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           +     +TP+H AA +D+ ++   L+++G+  +   K   +PL +AA +       TL+ 
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD           +HL    G    D  +             +N  + +G +PLH A+
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGH--VDMVSLLLGRNAN-----VNLSNKSGLTPLHLAA 705

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   E L+  GA ++ +     +PLH    YG       LL        +N     
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKN 762

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL   A  +    NG   L +A   GY   ++ L  V
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 818



 Score =  151 bits (366), Expect = 1e-35
 Identities = 135/531 (25%), Positives = 228/531 (42%), Gaps = 28/531 (5%)

Query: 32  LYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L L   +   V    G T  H A+   N N+   + N A  ++       TPLHVA +  
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
             + ++ LL +  +          P+H         V+++     +   +    ++G + 
Sbjct: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA--PILSKTKNGLSP 337

Query: 152 LHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCT 211
           LH A   DH  C ++L+   +       N+    +H AA     +  +V L   +++   
Sbjct: 338 LHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAAHCGHYKVAKVLL---DKKANP 393

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
             + ++     G  PLH A     IK +EL L+ GA I        TP+H+A   G ++I
Sbjct: 394 NAKALN-----GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
           V      Q     A   + +V+  T +H AA     E+V YL+ +G+ +    K+ ++PL
Sbjct: 449 VS-----QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            ++A       V  L++ GA       +    LHL    G   ED AA   DH   + L 
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH--EDVAAFLLDH--GASLS 559

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
           +  +K   G +PLH A++ G +     L++  A  +    +  +PLH AA Y     A  
Sbjct: 560 ITTKK---GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL 616

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           LLD         ++   G TPLHIA+++    +   LL  GA  +     G   +HLAA 
Sbjct: 617 LLDQGASPHAAAKN---GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            G+   + LL   ++++ +  +K G T LHLA  E++ +   +L++ G  +
Sbjct: 674 EGHVDMVSLLLGRNANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723



 Score =  144 bits (349), Expect = 2e-33
 Identities = 135/553 (24%), Positives = 241/553 (43%), Gaps = 45/553 (8%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +++AA +G+++  +  Y+     + + +  G  A H AS   +  ++  +     +++A 
Sbjct: 45  YLRAARAGHLEKALD-YIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+      +  ++    P++MA + N + V++      
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  + +   E G T L  A    HD    +L+  D   + + P       +H AA+   +
Sbjct: 164 A--SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------LHIAARKDDT 215

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS-TQQH 254
           +   + LQ         +    +    G  PLH A H G+I    L L   A +  T ++
Sbjct: 216 KAAALLLQ--------NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D+ TP+H+A  +G  ++VKL+      ++ A + +     +TP+HC A   H ++V  L+
Sbjct: 268 DI-TPLHVASKRGNANMVKLLL-----DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           +  + I    K   SPL +A        V  L++   ++ + D+ +  +  L V      
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--HNVPVDDVTNDYLTALHV------ 373

Query: 375 EDFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AA C  +   K LL      N K   G +PLH A ++  I+ +E L++ GA I    
Sbjct: 374 ---AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +P+H AA  G  +   QL+         N ++  G T LH+A+R G   VV  L+ 
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA +  +  + + PLH++A  G    ++ L        +     G T LHL+  E    
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHED 546

Query: 550 SIALLLSMGCRLS 562
             A LL  G  LS
Sbjct: 547 VAAFLLDHGASLS 559



 Score =  122 bits (294), Expect = 8e-27
 Identities = 102/416 (24%), Positives = 168/416 (40%), Gaps = 25/416 (6%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 533

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 534 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 586

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 587 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   +++N  +K   +
Sbjct: 645 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 755

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 756 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 33/136 (24%), Positives = 62/136 (45%), Gaps = 3/136 (2%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+VD  + L L   + + + +  G T  H A+  +  N+   + N    ++A+   
Sbjct: 671 AAQEGHVD-MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHV      +  + +LLQ   + +   +    P+H A +     ++ V  +  +  
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA-- 787

Query: 140 NVNQGGEHGRTALHFA 155
           + N+   +G TAL  A
Sbjct: 788 SPNELTVNGNTALGIA 803



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 1/125 (0%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S K  L+    AA+   V+    + +++ + +  +   G T  H      N  I++
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVN-VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 747

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
           F+  ++  +NAK   G TPLH A +      I  LLQ +   + L       + +A  L 
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807

Query: 125 KVSVL 129
            +SV+
Sbjct: 808 YISVV 812


>AL592430-3|CAI40518.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
           (ankyrin G) protein.
          Length = 4372

 Score =  160 bits (389), Expect = 2e-38
 Identities = 135/533 (25%), Positives = 231/533 (43%), Gaps = 39/533 (7%)

Query: 38  SRLAVRDGRGRT---AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALD 94
           S L   D +G+    A H A+ +++T     +     + + +  +G TPLH+A     ++
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHF 154
               LL +             P+H+A++    +++++     +   ++     G T LH 
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA--KIDAKTRDGLTPLHC 307

Query: 155 AAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQ 214
            A   H+   ++L+ D  A       NG  P+H A +      +++ LQ           
Sbjct: 308 GARSGHEQVVEMLL-DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--------HNV 358

Query: 215 MISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
            +    N+    LH A H G  K  ++ L   A  + +  +  TP+H+AC +  + +++L
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418

Query: 275 MFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           +       KH A + +     +TPIH AA   H  IV+ L++ G+  N  +    + L +
Sbjct: 419 LL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL- 392
           AA       V  L++ GA ++ K  + +  LH+    G          K    + LLQ  
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----------KADIVQQLLQQG 522

Query: 393 --LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              N    +G +PLH ++REGH      L+  GA +++      +PLH AA+YG+   A 
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAA 509
            LL          +S   GLTPLH+A+   + +V  LLL++GA  H    NG  PLH+AA
Sbjct: 583 LLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
                     L    +   + + + G  S+HLA  E     ++LLL     +S
Sbjct: 640 KKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS 691



 Score =  153 bits (372), Expect = 3e-36
 Identities = 119/476 (25%), Positives = 199/476 (41%), Gaps = 32/476 (6%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NAK   G TPLH+A +   +  +E LL+       
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  V+++     + +  + N     G TALH AA        + L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGA--SPNTTNVRGETALHMAARSGQAEVVRYLV 486

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            D  A+ +    +   P+H +A+   +  ++  LQ G                 G  PLH
Sbjct: 487 QD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT--------TSGYTPLH 537

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G        L  GA +S       TP+H+A   G L++  L+      +K A   
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-----QKSASPD 592

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           +     +TP+H AA +D+ ++   L+++G+  +   K   +PL +AA +       TL+ 
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD           +HL    G            H +   L L    + +G +PLH A+
Sbjct: 653 YGADANAVTRQGIASVHLAAQEG------------HVDMVSLLLGRNANVSGLTPLHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   E L+  GA ++ +     +PLH    YG       LL        +N     
Sbjct: 701 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKN 757

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL   A  +    NG   L +A   GY   ++ L  V
Sbjct: 758 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 813



 Score =  152 bits (368), Expect = 8e-36
 Identities = 141/570 (24%), Positives = 238/570 (41%), Gaps = 34/570 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ G+V+    L L   + +     +G TA H AS      ++  +     ++NA+   
Sbjct: 81  ASKEGHVEVVSEL-LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL++A +   L+ +++LL      S+  E    P+ +A +     V+ +      L 
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL------LL 193

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             +  G+    ALH AA  D    A +L+ + D        +G+ P+H AA   +     
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVAT 252

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L         R   +         PLH A   G+   V+L L  GAKI  +  D  TP
Sbjct: 253 LLL--------NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H     G   +V+++      ++ A + S     ++P+H A   DH   V  L+     
Sbjct: 305 LHCGARSGHEQVVEMLL-----DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++ +  +  + L +AA    ++    L+   A+   K +N    LH +     R++    
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH-IACKKNRIKVMEL 418

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             K     + +Q + E   +G +P+H A+  GH+  +  L+  GA  N  N   E+ LH 
Sbjct: 419 LLK---HGASIQAVTE---SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AAR G+     + L  D         D +  TPLHI++R G   +V  LL +GA  +   
Sbjct: 473 AARSGQAEVV-RYLVQDGAQVEAKAKDDQ--TPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            +G  PLHL+A  G+      L   H   L    K G T LH+A    K     LLL   
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 559 CRL-SYNNMDMSAIDYAIYYKFPEAALAMV 587
               +     ++ +  A +Y   + AL ++
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618



 Score =  145 bits (351), Expect = 9e-34
 Identities = 127/537 (23%), Positives = 224/537 (41%), Gaps = 34/537 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ GN +  ++L L   +++  +   G T  H  +   +  ++  + + A  + +K   
Sbjct: 275 ASKRGNAN-MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G +PLH+A + + L+ ++ LLQ +V    +       +H+A       V +V    K+  
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA-- 391

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 451 QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 503 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 615

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 616 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AA+ G       LL           ++  GLTPLH+A++E    V  +L+N+GA +  + 
Sbjct: 671 AAQEGHVDMVSLLLG--------RNANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 722

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 723 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 778



 Score =  144 bits (349), Expect = 2e-33
 Identities = 135/553 (24%), Positives = 241/553 (43%), Gaps = 45/553 (8%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +++AA +G+++  +  Y+     + + +  G  A H AS   +  ++  +     +++A 
Sbjct: 45  YLRAARAGHLEKALD-YIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+      +  ++    P++MA + N + V++      
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  + +   E G T L  A    HD    +L+  D   + + P       +H AA+   +
Sbjct: 164 A--SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------LHIAARKDDT 215

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS-TQQH 254
           +   + LQ         +    +    G  PLH A H G+I    L L   A +  T ++
Sbjct: 216 KAAALLLQ--------NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D+ TP+H+A  +G  ++VKL+      ++ A + +     +TP+HC A   H ++V  L+
Sbjct: 268 DI-TPLHVASKRGNANMVKLLL-----DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           +  + I    K   SPL +A        V  L++   ++ + D+ +  +  L V      
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--HNVPVDDVTNDYLTALHV------ 373

Query: 375 EDFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AA C  +   K LL      N K   G +PLH A ++  I+ +E L++ GA I    
Sbjct: 374 ---AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +P+H AA  G  +   QL+         N ++  G T LH+A+R G   VV  L+ 
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA +  +  + + PLH++A  G    ++ L        +     G T LHL+  E    
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHED 546

Query: 550 SIALLLSMGCRLS 562
             A LL  G  LS
Sbjct: 547 VAAFLLDHGASLS 559



 Score =  114 bits (275), Expect = 2e-24
 Identities = 101/416 (24%), Positives = 167/416 (40%), Gaps = 30/416 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 533

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 534 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 586

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 587 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++++ L     +
Sbjct: 645 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL-----T 694

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 695 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 750

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 751 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 802



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 24/83 (28%), Positives = 37/83 (44%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H      N  I++F+  ++  +NAK   G TPLH A +      I  LLQ +   
Sbjct: 725 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 784

Query: 107 SVLNEKCQAPIHMATELNKVSVL 129
           + L       + +A  L  +SV+
Sbjct: 785 NELTVNGNTALGIARRLGYISVV 807


>AL359377-2|CAI41373.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
           (ankyrin G) protein.
          Length = 4372

 Score =  160 bits (389), Expect = 2e-38
 Identities = 135/533 (25%), Positives = 231/533 (43%), Gaps = 39/533 (7%)

Query: 38  SRLAVRDGRGRT---AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALD 94
           S L   D +G+    A H A+ +++T     +     + + +  +G TPLH+A     ++
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHF 154
               LL +             P+H+A++    +++++     +   ++     G T LH 
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA--KIDAKTRDGLTPLHC 307

Query: 155 AAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQ 214
            A   H+   ++L+ D  A       NG  P+H A +      +++ LQ           
Sbjct: 308 GARSGHEQVVEMLL-DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--------HNV 358

Query: 215 MISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
            +    N+    LH A H G  K  ++ L   A  + +  +  TP+H+AC +  + +++L
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418

Query: 275 MFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           +       KH A + +     +TPIH AA   H  IV+ L++ G+  N  +    + L +
Sbjct: 419 LL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL- 392
           AA       V  L++ GA ++ K  + +  LH+    G          K    + LLQ  
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----------KADIVQQLLQQG 522

Query: 393 --LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              N    +G +PLH ++REGH      L+  GA +++      +PLH AA+YG+   A 
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAA 509
            LL          +S   GLTPLH+A+   + +V  LLL++GA  H    NG  PLH+AA
Sbjct: 583 LLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
                     L    +   + + + G  S+HLA  E     ++LLL     +S
Sbjct: 640 KKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS 691



 Score =  153 bits (372), Expect = 3e-36
 Identities = 119/476 (25%), Positives = 199/476 (41%), Gaps = 32/476 (6%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NAK   G TPLH+A +   +  +E LL+       
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  V+++     + +  + N     G TALH AA        + L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGA--SPNTTNVRGETALHMAARSGQAEVVRYLV 486

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            D  A+ +    +   P+H +A+   +  ++  LQ G                 G  PLH
Sbjct: 487 QD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT--------TSGYTPLH 537

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G        L  GA +S       TP+H+A   G L++  L+      +K A   
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-----QKSASPD 592

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           +     +TP+H AA +D+ ++   L+++G+  +   K   +PL +AA +       TL+ 
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD           +HL    G            H +   L L    + +G +PLH A+
Sbjct: 653 YGADANAVTRQGIASVHLAAQEG------------HVDMVSLLLGRNANVSGLTPLHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   E L+  GA ++ +     +PLH    YG       LL        +N     
Sbjct: 701 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKN 757

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL   A  +    NG   L +A   GY   ++ L  V
Sbjct: 758 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 813



 Score =  152 bits (368), Expect = 8e-36
 Identities = 141/570 (24%), Positives = 238/570 (41%), Gaps = 34/570 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ G+V+    L L   + +     +G TA H AS      ++  +     ++NA+   
Sbjct: 81  ASKEGHVEVVSEL-LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL++A +   L+ +++LL      S+  E    P+ +A +     V+ +      L 
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL------LL 193

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             +  G+    ALH AA  D    A +L+ + D        +G+ P+H AA   +     
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVAT 252

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L         R   +         PLH A   G+   V+L L  GAKI  +  D  TP
Sbjct: 253 LLL--------NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H     G   +V+++      ++ A + S     ++P+H A   DH   V  L+     
Sbjct: 305 LHCGARSGHEQVVEMLL-----DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++ +  +  + L +AA    ++    L+   A+   K +N    LH +     R++    
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH-IACKKNRIKVMEL 418

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             K     + +Q + E   +G +P+H A+  GH+  +  L+  GA  N  N   E+ LH 
Sbjct: 419 LLK---HGASIQAVTE---SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AAR G+     + L  D         D +  TPLHI++R G   +V  LL +GA  +   
Sbjct: 473 AARSGQAEVV-RYLVQDGAQVEAKAKDDQ--TPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            +G  PLHL+A  G+      L   H   L    K G T LH+A    K     LLL   
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 559 CRL-SYNNMDMSAIDYAIYYKFPEAALAMV 587
               +     ++ +  A +Y   + AL ++
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618



 Score =  145 bits (351), Expect = 9e-34
 Identities = 127/537 (23%), Positives = 224/537 (41%), Gaps = 34/537 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ GN +  ++L L   +++  +   G T  H  +   +  ++  + + A  + +K   
Sbjct: 275 ASKRGNAN-MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G +PLH+A + + L+ ++ LLQ +V    +       +H+A       V +V    K+  
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA-- 391

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 451 QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 503 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 615

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 616 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AA+ G       LL           ++  GLTPLH+A++E    V  +L+N+GA +  + 
Sbjct: 671 AAQEGHVDMVSLLLG--------RNANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 722

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 723 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 778



 Score =  144 bits (349), Expect = 2e-33
 Identities = 135/553 (24%), Positives = 241/553 (43%), Gaps = 45/553 (8%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +++AA +G+++  +  Y+     + + +  G  A H AS   +  ++  +     +++A 
Sbjct: 45  YLRAARAGHLEKALD-YIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+      +  ++    P++MA + N + V++      
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  + +   E G T L  A    HD    +L+  D   + + P       +H AA+   +
Sbjct: 164 A--SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------LHIAARKDDT 215

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS-TQQH 254
           +   + LQ         +    +    G  PLH A H G+I    L L   A +  T ++
Sbjct: 216 KAAALLLQ--------NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D+ TP+H+A  +G  ++VKL+      ++ A + +     +TP+HC A   H ++V  L+
Sbjct: 268 DI-TPLHVASKRGNANMVKLLL-----DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           +  + I    K   SPL +A        V  L++   ++ + D+ +  +  L V      
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--HNVPVDDVTNDYLTALHV------ 373

Query: 375 EDFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AA C  +   K LL      N K   G +PLH A ++  I+ +E L++ GA I    
Sbjct: 374 ---AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +P+H AA  G  +   QL+         N ++  G T LH+A+R G   VV  L+ 
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA +  +  + + PLH++A  G    ++ L        +     G T LHL+  E    
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHED 546

Query: 550 SIALLLSMGCRLS 562
             A LL  G  LS
Sbjct: 547 VAAFLLDHGASLS 559



 Score =  114 bits (275), Expect = 2e-24
 Identities = 101/416 (24%), Positives = 167/416 (40%), Gaps = 30/416 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 533

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 534 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 586

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 587 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++++ L     +
Sbjct: 645 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL-----T 694

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 695 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 750

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 751 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 802



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 24/83 (28%), Positives = 37/83 (44%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H      N  I++F+  ++  +NAK   G TPLH A +      I  LLQ +   
Sbjct: 725 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 784

Query: 107 SVLNEKCQAPIHMATELNKVSVL 129
           + L       + +A  L  +SV+
Sbjct: 785 NELTVNGNTALGIARRLGYISVV 807


>AL359267-1|CAH73232.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
           (ankyrin G) protein.
          Length = 4372

 Score =  160 bits (389), Expect = 2e-38
 Identities = 135/533 (25%), Positives = 231/533 (43%), Gaps = 39/533 (7%)

Query: 38  SRLAVRDGRGRT---AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALD 94
           S L   D +G+    A H A+ +++T     +     + + +  +G TPLH+A     ++
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHF 154
               LL +             P+H+A++    +++++     +   ++     G T LH 
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA--KIDAKTRDGLTPLHC 307

Query: 155 AAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQ 214
            A   H+   ++L+ D  A       NG  P+H A +      +++ LQ           
Sbjct: 308 GARSGHEQVVEMLL-DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--------HNV 358

Query: 215 MISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
            +    N+    LH A H G  K  ++ L   A  + +  +  TP+H+AC +  + +++L
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418

Query: 275 MFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           +       KH A + +     +TPIH AA   H  IV+ L++ G+  N  +    + L +
Sbjct: 419 LL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL- 392
           AA       V  L++ GA ++ K  + +  LH+    G          K    + LLQ  
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----------KADIVQQLLQQG 522

Query: 393 --LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              N    +G +PLH ++REGH      L+  GA +++      +PLH AA+YG+   A 
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAA 509
            LL          +S   GLTPLH+A+   + +V  LLL++GA  H    NG  PLH+AA
Sbjct: 583 LLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
                     L    +   + + + G  S+HLA  E     ++LLL     +S
Sbjct: 640 KKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS 691



 Score =  153 bits (372), Expect = 3e-36
 Identities = 119/476 (25%), Positives = 199/476 (41%), Gaps = 32/476 (6%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA H A+   +  +   + +   + NAK   G TPLH+A +   +  +E LL+       
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           + E    PIH+A  +  V+++     + +  + N     G TALH AA        + L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGA--SPNTTNVRGETALHMAARSGQAEVVRYLV 486

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            D  A+ +    +   P+H +A+   +  ++  LQ G                 G  PLH
Sbjct: 487 QD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT--------TSGYTPLH 537

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            +   G        L  GA +S       TP+H+A   G L++  L+      +K A   
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-----QKSASPD 592

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
           +     +TP+H AA +D+ ++   L+++G+  +   K   +PL +AA +       TL+ 
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD           +HL    G            H +   L L    + +G +PLH A+
Sbjct: 653 YGADANAVTRQGIASVHLAAQEG------------HVDMVSLLLGRNANVSGLTPLHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           +E  +   E L+  GA ++ +     +PLH    YG       LL        +N     
Sbjct: 701 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKN 757

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
           G TPLH A+++GHT ++++LL   A  +    NG   L +A   GY   ++ L  V
Sbjct: 758 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 813



 Score =  152 bits (368), Expect = 8e-36
 Identities = 141/570 (24%), Positives = 238/570 (41%), Gaps = 34/570 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ G+V+    L L   + +     +G TA H AS      ++  +     ++NA+   
Sbjct: 81  ASKEGHVEVVSEL-LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL++A +   L+ +++LL      S+  E    P+ +A +     V+ +      L 
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL------LL 193

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             +  G+    ALH AA  D    A +L+ + D        +G+ P+H AA   +     
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVAT 252

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L         R   +         PLH A   G+   V+L L  GAKI  +  D  TP
Sbjct: 253 LLL--------NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H     G   +V+++      ++ A + S     ++P+H A   DH   V  L+     
Sbjct: 305 LHCGARSGHEQVVEMLL-----DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++ +  +  + L +AA    ++    L+   A+   K +N    LH +     R++    
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH-IACKKNRIKVMEL 418

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             K     + +Q + E   +G +P+H A+  GH+  +  L+  GA  N  N   E+ LH 
Sbjct: 419 LLK---HGASIQAVTE---SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AAR G+     + L  D         D +  TPLHI++R G   +V  LL +GA  +   
Sbjct: 473 AARSGQAEVV-RYLVQDGAQVEAKAKDDQ--TPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            +G  PLHL+A  G+      L   H   L    K G T LH+A    K     LLL   
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 559 CRL-SYNNMDMSAIDYAIYYKFPEAALAMV 587
               +     ++ +  A +Y   + AL ++
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618



 Score =  145 bits (351), Expect = 9e-34
 Identities = 127/537 (23%), Positives = 224/537 (41%), Gaps = 34/537 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A++ GN +  ++L L   +++  +   G T  H  +   +  ++  + + A  + +K   
Sbjct: 275 ASKRGNAN-MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G +PLH+A + + L+ ++ LLQ +V    +       +H+A       V +V    K+  
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA-- 391

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 451 QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 503 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 615

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 616 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RD 498
           AA+ G       LL           ++  GLTPLH+A++E    V  +L+N+GA +  + 
Sbjct: 671 AAQEGHVDMVSLLLG--------RNANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 722

Query: 499 HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 723 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 778



 Score =  144 bits (349), Expect = 2e-33
 Identities = 135/553 (24%), Positives = 241/553 (43%), Gaps = 45/553 (8%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +++AA +G+++  +  Y+     + + +  G  A H AS   +  ++  +     +++A 
Sbjct: 45  YLRAARAGHLEKALD-YIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              GNT LH+A      + ++ L+      +  ++    P++MA + N + V++      
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-TDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +  + +   E G T L  A    HD    +L+  D   + + P       +H AA+   +
Sbjct: 164 A--SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------LHIAARKDDT 215

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS-TQQH 254
           +   + LQ         +    +    G  PLH A H G+I    L L   A +  T ++
Sbjct: 216 KAAALLLQ--------NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D+ TP+H+A  +G  ++VKL+      ++ A + +     +TP+HC A   H ++V  L+
Sbjct: 268 DI-TPLHVASKRGNANMVKLLL-----DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           +  + I    K   SPL +A        V  L++   ++ + D+ +  +  L V      
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--HNVPVDDVTNDYLTALHV------ 373

Query: 375 EDFAASCKDH-CEKSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AA C  +   K LL      N K   G +PLH A ++  I+ +E L++ GA I    
Sbjct: 374 ---AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +  +P+H AA  G  +   QL+         N ++  G T LH+A+R G   VV  L+ 
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA +  +  + + PLH++A  G    ++ L        +     G T LHL+  E    
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHED 546

Query: 550 SIALLLSMGCRLS 562
             A LL  G  LS
Sbjct: 547 VAAFLLDHGASLS 559



 Score =  114 bits (275), Expect = 2e-24
 Identities = 101/416 (24%), Positives = 167/416 (40%), Gaps = 30/416 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 533

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 534 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 586

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 587 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++++ L     +
Sbjct: 645 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL-----T 694

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 695 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 750

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 751 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 802



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 24/83 (28%), Positives = 37/83 (44%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H      N  I++F+  ++  +NAK   G TPLH A +      I  LLQ +   
Sbjct: 725 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 784

Query: 107 SVLNEKCQAPIHMATELNKVSVL 129
           + L       + +A  L  +SV+
Sbjct: 785 NELTVNGNTALGIARRLGYISVV 807


>BC016985-1|AAH16985.2|  579|Homo sapiens ANKRD44 protein protein.
          Length = 579

 Score =  156 bits (379), Expect = 4e-37
 Identities = 136/513 (26%), Positives = 219/513 (42%), Gaps = 33/513 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           VQA  SG+ ++ +R+ + +   +   D   RT  H A+   +  I+  +      +NAKD
Sbjct: 13  VQAIFSGDPEE-IRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD 71

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           N   TPLH AV + + +A++ L++   + +  ++  Q P+H+A     V   +V     S
Sbjct: 72  NMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 131

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             NV+  G  GRTALH AA++ H     +L+    A            +H AA       
Sbjct: 132 SVNVSDRG--GRTALHHAALNGHVEMVNLLLAK-GANINAFDKKDRRALHWAAYMGHLDV 188

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           + + +  G +  C         D +G  PLH+A   G I  V+  L  G +I       +
Sbjct: 189 VALLINHGAEVTCK--------DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGN 240

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI-VNYLINE 316
           T +H+AC  G   +V  +      +  A +   +    TP+H AA   H  + +  L+N 
Sbjct: 241 TALHIACYNGQDAVVNELI-----DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 295

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL-- 374
           G+D+N   K+ +SPL + A    +    TLI+ G +I   D +    LH+    G  L  
Sbjct: 296 GADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLI 355

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNE 434
                S  D  +  +  +          PLH A+   H      L+  G  I+  +    
Sbjct: 356 NTLITSGADTAKCGIHSMF---------PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGR 406

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           + LH AA  G      +LL S    F  ++ D  G TPLH A+   H   +  L+  GA 
Sbjct: 407 TCLHAAAAGGNVE-CIKLLQSSGADF--HKKDKCGRTPLHYAAANCHFHCIETLVTTGAN 463

Query: 495 LHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSH 526
           ++  D  GR  LH AA S   +   +L + H +
Sbjct: 464 VNETDDWGRTALHYAAASDMDRNKTILGNAHDN 496



 Score =  149 bits (361), Expect = 6e-35
 Identities = 119/422 (28%), Positives = 194/422 (45%), Gaps = 29/422 (6%)

Query: 140 NVNQGGEHGRTALHFAA-IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           +VN      RT LH AA + D ++   ++++      K   N    P+H A  + S   +
Sbjct: 33  DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD--NMWLTPLHRAVASRSEEAV 90

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +V ++            ++  D     PLH A     +K  E+ +   + ++       T
Sbjct: 91  QVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRT 142

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
            +H A   G +++V L+       K A + + D +    +H AA   H ++V  LIN G+
Sbjct: 143 ALHHAALNGHVEMVNLLLA-----KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 197

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           ++   DK+  +PL  AAS      V  L+ LG +I   ++     LH+   NG   +   
Sbjct: 198 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ--DAVV 255

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH-IRSLENLIRLGACINLKNNNNESPL 437
               D+        +N+ +N G +PLH+A+   H    LE L+  GA +N+++ + +SPL
Sbjct: 256 NELIDYGAN-----VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 310

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           H  A +GRF T  Q L  + G   I+  D +G TPLH+A+R GH  +++ L+  GA   +
Sbjct: 311 HMTAVHGRF-TRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTLITSGADTAK 367

Query: 498 -DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
              +   PLHLAA++ ++     L S     +D  DK G T LH A        I LL S
Sbjct: 368 CGIHSMFPLHLAALNAHSDCCRKLLS-SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 426

Query: 557 MG 558
            G
Sbjct: 427 SG 428



 Score =  136 bits (328), Expect = 6e-31
 Identities = 123/458 (26%), Positives = 202/458 (44%), Gaps = 44/458 (9%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           S + V D  GRTA H A+   +  +++ +     ++NA D      LH A     LD + 
Sbjct: 131 SSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 190

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            L+    E +  ++K   P+H A    +++V++          +++   +G TALH A  
Sbjct: 191 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG--VEIDEINVYGNTALHIACY 248

Query: 158 HDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA-SSRTIEVFLQWGEQRGCTREQMI 216
           +  D     LI D  A   +P NNG+ P+H AA +   +  +E+ +  G          +
Sbjct: 249 NGQDAVVNELI-DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD--------V 299

Query: 217 SLYDNEGNVPLH-SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           ++   +G  PLH +AVHG   ++  L +++G +I     D +TP+H+A   G   ++  +
Sbjct: 300 NIQSKDGKSPLHMTAVHGRFTRSQTL-IQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 358

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
            T       A    C +  M P+H AA+  H +    L++ G +I+  DK  R+ L  AA
Sbjct: 359 IT-----SGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAA 413

Query: 336 SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--- 392
           +      +  L   GAD   KD   R  LH            AA+C  HC ++L+     
Sbjct: 414 AGGNVECIKLLQSSGADFHKKDKCGRTPLHYA----------AANCHFHCIETLVTTGAN 463

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ- 451
           +NE D+ G + LHYA+     R   N   LG      ++N+E          +  T C  
Sbjct: 464 VNETDDWGRTALHYAAASDMDR---NKTILGNA----HDNSEELERARELKEKEATLCLE 516

Query: 452 -LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
            LL +D    I    D EG   +H A+  GH + + L+
Sbjct: 517 FLLQNDANPSI---RDKEGYNSIHYAAAYGHRQCLELV 551



 Score =  126 bits (305), Expect = 4e-28
 Identities = 125/505 (24%), Positives = 207/505 (40%), Gaps = 39/505 (7%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +   ++ +++ +   + +  RD   +T  H A+A         I      +N  D  G
Sbjct: 81  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 140

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            T LH A  N  ++ +  LL +    +  ++K +  +H A  +  + V+ +   + +   
Sbjct: 141 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA--E 198

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           V    + G T LH AA +      K L+ +L  E  +    G   +H A  N     +  
Sbjct: 199 VTCKDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNE 257

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAV---HGGDIKAVELCLRSGAKISTQQHDLS 257
            + +G          ++  +N G  PLH A    HG     +EL + +GA ++ Q  D  
Sbjct: 258 LIDYGAN--------VNQPNNNGFTPLHFAAASTHGA--LCLELLVNNGADVNIQSKDGK 307

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           +P+H+    G     +    +Q   +  C+   D    TP+H AA + H  ++N LI  G
Sbjct: 308 SPLHMTAVHGRF--TRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTLITSG 362

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           +D          PL LAA  A       L+  G +I   D   R  LH     GG +E  
Sbjct: 363 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAA-GGNVE-- 419

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
              C    + S     ++KD  G +PLHYA+   H   +E L+  GA +N  ++   + L
Sbjct: 420 ---CIKLLQSSGADF-HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 475

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDG--EGLTPLHIASREGHTRVVHLLLNRGALL 495
           H+AA           +D +K T + N  D   E      +  +E    +  LL N     
Sbjct: 476 HYAAASD--------MDRNK-TILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 526

Query: 496 HRDHNGRNPLHLAAMSGYTKTIELL 520
            RD  G N +H AA  G+ + +EL+
Sbjct: 527 IRDKEGYNSIHYAAAYGHRQCLELV 551



 Score =  118 bits (283), Expect = 2e-25
 Identities = 93/335 (27%), Positives = 160/335 (47%), Gaps = 18/335 (5%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD + + + +     ++T   +  TP+H+A   G  +I++L+         A
Sbjct: 11  PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLIL-----SGA 65

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + + D   +TP+H A      E V  LI   +D+N  DK  ++PL +AA+    +    
Sbjct: 66  RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEV 125

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           +I L + + + D   R  LH   +N G +E          + + +   ++KD      LH
Sbjct: 126 IIPLLSSVNVSDRGGRTALHHAALN-GHVEMVNLLL---AKGANINAFDKKDRRA---LH 178

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
           +A+  GH+  +  LI  GA +  K+    +PLH AA  G+ +    LL+       I+E 
Sbjct: 179 WAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG---VEIDEI 235

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGY-TKTIELLHSV 523
           +  G T LHIA   G   VV+ L++ GA +++ ++NG  PLH AA S +    +ELL + 
Sbjct: 236 NVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 295

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            + +  Q  KDG + LH+  +  + +    L+  G
Sbjct: 296 GADVNIQ-SKDGKSPLHMTAVHGRFTRSQTLIQNG 329



 Score =  106 bits (255), Expect = 4e-22
 Identities = 84/280 (30%), Positives = 131/280 (46%), Gaps = 13/280 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  A     PE +  LI++  D+N LD E+R+PL +AA       +  LI  GA +  K
Sbjct: 11  PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK 70

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D      LH  V    R E+       H        +N +D    +PLH A+    ++  
Sbjct: 71  DNMWLTPLHRAV--ASRSEEAVQVLIKHSAD-----VNARDKNWQTPLHVAAANKAVKCA 123

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           E +I L + +N+ +    + LH AA  G       LL   KG   IN  D +    LH A
Sbjct: 124 EVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL--AKGA-NINAFDKKDRRALHWA 180

Query: 477 SREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
           +  GH  VV LL+N GA +  +D  G  PLH AA +G    ++ L ++    +D+I+  G
Sbjct: 181 AYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE-IDEINVYG 239

Query: 536 NTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYA 574
           NT+LH+A    + + +  L+  G  ++  NN   + + +A
Sbjct: 240 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 279



 Score = 40.7 bits (91), Expect = 0.030
 Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 8/167 (4%)

Query: 1   STYIHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNT 60
           S+   + T  K   +    AA  GNV+  ++L  S  +    +D  GRT  H A+A  + 
Sbjct: 393 SSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 451

Query: 61  NILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           + +  +     ++N  D+ G T LH A  ++ +D  + +L    + S   E+ +      
Sbjct: 452 HCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTILGNAHDNSEELERARELKEKE 510

Query: 121 TELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             L    +LQ  A      N +   + G  ++H+AA + H  C +++
Sbjct: 511 ATLCLEFLLQNDA------NPSIRDKEGYNSIHYAAAYGHRQCLELV 551


>AC013264-1|AAX93155.1|  525|Homo sapiens unknown protein.
          Length = 525

 Score =  156 bits (378), Expect = 5e-37
 Identities = 131/485 (27%), Positives = 220/485 (45%), Gaps = 29/485 (5%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D+N  D+   TPLHVA      + IE L+      +  +     P+H A        +QV
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
             K+ +  +VN   ++ +T LH AA +    CA+++I  L +        G   +H AA 
Sbjct: 68  LIKHSA--DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAAL 124

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
           N     + + L  G          I+ +D +    LH A + G +  V L +  GA+++ 
Sbjct: 125 NGHVEMVNLLLAKGAN--------INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN 311
           +     TP+H A + G +++VK +  +  +     +   +V   T +H A       +VN
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVE-----IDEINVYGNTALHIACYNGQDAVVN 231

Query: 312 YLINEGSDINPLDKERRSPL-LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMN 370
            LI+ G+++N  +    +PL   AAS  G   +  L+  GAD+ ++  + ++ LH+  ++
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVH 291

Query: 371 GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
            GR        ++  E      ++  D  G +PLH A+R GH   +  LI  GA      
Sbjct: 292 -GRFTRSQTLIQNGGE------IDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCG 344

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            ++  PLH AA         +LL S    F I+  D  G T LH A+  G+   + LL +
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSG---FEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 491 RGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
            GA  H +D  GR PLH AA + +   IE L +  ++ +++ D  G T+LH A   +   
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASDMDR 460

Query: 550 SIALL 554
           +  +L
Sbjct: 461 NKTIL 465



 Score =  151 bits (365), Expect = 2e-35
 Identities = 130/487 (26%), Positives = 205/487 (42%), Gaps = 32/487 (6%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D   RT  H A+   +  I+  +      +NAKDN   TPLH AV + + +A++ L++  
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 104 VETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC 163
            + +  ++  Q P+H+A     V   +V     S  NV+  G  GRTALH AA++ H   
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG--GRTALHHAALNGHVEM 130

Query: 164 AKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
             +L+    A            +H AA       + + +  G +  C         D +G
Sbjct: 131 VNLLLAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--------DKKG 181

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEK 283
             PLH+A   G I  V+  L  G +I       +T +H+AC  G   +V  +      + 
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI-----DY 236

Query: 284 HACLTSCDVQKMTPIHCAAMFDHPEI-VNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
            A +   +    TP+H AA   H  + +  L+N G+D+N   K+ +SPL + A    +  
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHCEKSLLQLLNEKDNTG 400
             TLI+ G +I   D +    LH+    G  L       S  D  +  +  +        
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMF------- 349

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
             PLH A+   H      L+  G  I+  +    + LH AA  G      +LL S    F
Sbjct: 350 --PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQSSGADF 406

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIEL 519
             ++ D  G TPLH A+   H   +  L+  GA ++  D  GR  LH AA S   +   +
Sbjct: 407 --HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464

Query: 520 LHSVHSH 526
           L + H +
Sbjct: 465 LGNAHDN 471



 Score =  149 bits (361), Expect = 6e-35
 Identities = 119/422 (28%), Positives = 194/422 (45%), Gaps = 29/422 (6%)

Query: 140 NVNQGGEHGRTALHFAA-IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           +VN      RT LH AA + D ++   ++++      K   N    P+H A  + S   +
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD--NMWLTPLHRAVASRSEEAV 65

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +V ++            ++  D     PLH A     +K  E+ +   + ++       T
Sbjct: 66  QVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRT 117

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
            +H A   G +++V L+       K A + + D +    +H AA   H ++V  LIN G+
Sbjct: 118 ALHHAALNGHVEMVNLLLA-----KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           ++   DK+  +PL  AAS      V  L+ LG +I   ++     LH+   NG   +   
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ--DAVV 230

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH-IRSLENLIRLGACINLKNNNNESPL 437
               D+        +N+ +N G +PLH+A+   H    LE L+  GA +N+++ + +SPL
Sbjct: 231 NELIDYGAN-----VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           H  A +GRF T  Q L  + G   I+  D +G TPLH+A+R GH  +++ L+  GA   +
Sbjct: 286 HMTAVHGRF-TRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTLITSGADTAK 342

Query: 498 -DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
              +   PLHLAA++ ++     L S     +D  DK G T LH A        I LL S
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLS-SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 557 MG 558
            G
Sbjct: 402 SG 403



 Score =  137 bits (331), Expect = 2e-31
 Identities = 125/467 (26%), Positives = 203/467 (43%), Gaps = 33/467 (7%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + + L +   +R+  +D    T  H+A A  +   +  +  ++ D+NA+D    TPLHVA
Sbjct: 30  EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVA 89

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             N+A+   E ++      +V +   +  +H A     V ++ +     +  N+N   + 
Sbjct: 90  AANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA--NINAFDKK 147

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
            R ALH+AA   H L    L+ +  AE       GY P+H AA N     ++  L  G  
Sbjct: 148 DRRALHWAAYMGH-LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG-- 204

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA-- 265
                   I++Y   GN  LH A + G    V   +  GA ++   ++  TP+H A A  
Sbjct: 205 ---VEIDEINVY---GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
            GAL +  L+         A +        +P+H  A+         LI  G +I+ +DK
Sbjct: 259 HGALCLELLV------NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHC 385
           +  +PL +AA       ++TLI  GAD     I+S   LHL  +N         +  D C
Sbjct: 313 DGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALN---------AHSDCC 363

Query: 386 EKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARY 443
            K L     ++  D  G + LH A+  G++  ++ L   GA  + K+    +PLH+AA  
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423

Query: 444 GRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
             FH    L+ +      +NE+D  G T LH A+     R   +L N
Sbjct: 424 CHFHCIETLVTTGAN---VNETDDWGRTALHYAAASDMDRNKTILGN 467



 Score =  133 bits (321), Expect = 4e-30
 Identities = 112/434 (25%), Positives = 194/434 (44%), Gaps = 36/434 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+V+  + L L++ + +   D + R A H A+   + +++  + N+  ++  KD  
Sbjct: 122 AALNGHVE-MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  N  ++ +++LL   VE   +N      +H+A    + +V+     Y +  
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA-- 238

Query: 140 NVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVNQ   +G T LHFAA   H  LC ++L+ +  A+      +G  P+H  A +      
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRS 297

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  +Q G +  C         D +GN PLH A   G    +   + SGA  +        
Sbjct: 298 QTLIQNGGEIDCV--------DKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMF 349

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           P+HLA      D  + + +   +     + + D    T +H AA   + E +  L + G+
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFE-----IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG-GRLEDF 377
           D +  DK  R+PL  AA+   +  + TL+  GA++   D   R  LH    +   R +  
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464

Query: 378 AASCKDHCEK-SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
             +  D+ E+    + L EK+ T C              LE L++  A  ++++    + 
Sbjct: 465 LGNAHDNSEELERARELKEKEATLC--------------LEFLLQNDANPSIRDKEGYNS 510

Query: 437 LHFAARYGRFHTAC 450
           +H+AA YG  H  C
Sbjct: 511 IHYAAAYG--HRQC 522



 Score =  126 bits (304), Expect = 5e-28
 Identities = 124/504 (24%), Positives = 207/504 (41%), Gaps = 39/504 (7%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +   ++ +++ +   + +  RD   +T  H A+A         I      +N  D  G
Sbjct: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            T LH A  N  ++ +  LL +    +  ++K +  +H A  +  + V+ +   + +   
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA--E 173

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           V    + G T LH AA +      K L+ +L  E  +    G   +H A  N     +  
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNE 232

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLH---SAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            + +G          ++  +N G  PLH   ++ HG     +EL + +GA ++ Q  D  
Sbjct: 233 LIDYGAN--------VNQPNNNGFTPLHFAAASTHGA--LCLELLVNNGADVNIQSKDGK 282

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           +P+H+    G     +    +Q   +  C+   D    TP+H AA + H  ++N LI  G
Sbjct: 283 SPLHMTAVHGR--FTRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTLITSG 337

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           +D          PL LAA  A       L+  G +I   D   R  LH     GG +E  
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAA-GGNVE-- 394

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
              C    + S     ++KD  G +PLHYA+   H   +E L+  GA +N  ++   + L
Sbjct: 395 ---CIKLLQSSGAD-FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDG--EGLTPLHIASREGHTRVVHLLLNRGALL 495
           H+A        A   +D +K T + N  D   E      +  +E    +  LL N     
Sbjct: 451 HYA--------AASDMDRNK-TILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 501

Query: 496 HRDHNGRNPLHLAAMSGYTKTIEL 519
            RD  G N +H AA  G+ + +EL
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLEL 525



 Score =  107 bits (258), Expect = 2e-22
 Identities = 80/283 (28%), Positives = 128/283 (45%), Gaps = 13/283 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           + + D +K TP+H AA     EI+  LI  G+ +N  D    +PL  A +      V  L
Sbjct: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           I+  AD+  +D N +  LH+   N       A  C +     LL  +N  D  G + LH+
Sbjct: 69  IKHSADVNARDKNWQTPLHVAAANK------AVKCAE-VIIPLLSSVNVSDRGGRTALHH 121

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+  GH+  +  L+  GA IN  +  +   LH+AA  G       L++       +   D
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE---VTCKD 178

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHS 525
            +G TPLH A+  G   VV  LLN G  +   +  G   LH+A  +G    +  L    +
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 526 HLLDQIDKDGNTSLHLATMENKPS-SIALLLSMGCRLSYNNMD 567
           + ++Q + +G T LH A      +  + LL++ G  ++  + D
Sbjct: 239 N-VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 280



 Score =  101 bits (242), Expect = 2e-20
 Identities = 80/264 (30%), Positives = 125/264 (47%), Gaps = 13/264 (4%)

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           LI++  D+N LD E+R+PL +AA       +  LI  GA +  KD      LH  V    
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV--AS 59

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           R E+       H        +N +D    +PLH A+    ++  E +I L + +N+ +  
Sbjct: 60  RSEEAVQVLIKHSAD-----VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             + LH AA  G       LL   KG   IN  D +    LH A+  GH  VV LL+N G
Sbjct: 115 GRTALHHAALNGHVEMVNLLL--AKGA-NINAFDKKDRRALHWAAYMGHLDVVALLINHG 171

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A +  +D  G  PLH AA +G    ++ L ++    +D+I+  GNT+LH+A    + + +
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE-IDEINVYGNTALHIACYNGQDAVV 230

Query: 552 ALLLSMGCRLSY-NNMDMSAIDYA 574
             L+  G  ++  NN   + + +A
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFA 254



 Score = 40.3 bits (90), Expect = 0.040
 Identities = 39/166 (23%), Positives = 72/166 (43%), Gaps = 8/166 (4%)

Query: 1   STYIHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNT 60
           S+   + T  K   +    AA  GNV+  ++L  S  +    +D  GRT  H A+A  + 
Sbjct: 368 SSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426

Query: 61  NILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           + +  +     ++N  D+ G T LH A  ++ +D  + +L    + S   E+ +      
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTILGNAHDNSEELERARELKEKE 485

Query: 121 TELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
             L    +LQ  A      N +   + G  ++H+AA + H  C ++
Sbjct: 486 ATLCLEFLLQNDA------NPSIRDKEGYNSIHYAAAYGHRQCLEL 525


>AL592430-2|CAI40517.1| 1071|Homo sapiens ankyrin 3, node of Ranvier
           (ankyrin G) protein.
          Length = 1071

 Score =  150 bits (364), Expect = 3e-35
 Identities = 115/451 (25%), Positives = 189/451 (41%), Gaps = 32/451 (7%)

Query: 74  NAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFA 133
           NAK   G TPLH+A +   +  +E LL+       + E    PIH+A  +  V+++    
Sbjct: 9   NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 68

Query: 134 KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
            + +  + N     G TALH AA        + L+ D  A+ +    +   P+H +A+  
Sbjct: 69  HHGA--SPNTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLG 125

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
            +  ++  LQ G                 G  PLH +   G        L  GA +S   
Sbjct: 126 KADIVQQLLQQGASPNAA--------TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 177

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
               TP+H+A   G L++  L+      +K A   +     +TP+H AA +D+ ++   L
Sbjct: 178 KKGFTPLHVAAKYGKLEVANLLL-----QKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 232

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +++G+  +   K   +PL +AA +       TL+  GAD           +HL    G  
Sbjct: 233 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG-- 290

Query: 374 LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                     H +   L L    + +G +PLH A++E  +   E L+  GA ++ +    
Sbjct: 291 ----------HVDMVSLLLGRNANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 340

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH    YG       LL        +N     G TPLH A+++GHT ++++LL   A
Sbjct: 341 YTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 397

Query: 494 LLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
             +    NG   L +A   GY   ++ L  V
Sbjct: 398 SPNELTVNGNTALGIARRLGYISVVDTLKIV 428



 Score =  121 bits (292), Expect = 1e-26
 Identities = 91/310 (29%), Positives = 144/310 (46%), Gaps = 25/310 (8%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
           TP+H+AC +  + +++L+       KH A + +     +TPIH AA   H  IV+ L++ 
Sbjct: 17  TPLHIACKKNRIKVMELLL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 70

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G+  N  +    + L +AA       V  L++ GA ++ K  + +  LH+    G     
Sbjct: 71  GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----- 125

Query: 377 FAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                K    + LLQ     N    +G +PLH ++REGH      L+  GA +++     
Sbjct: 126 -----KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 180

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH AA+YG+   A  LL          +S   GLTPLH+A+   + +V  LLL++GA
Sbjct: 181 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGA 237

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
             H    NG  PLH+AA          L    +   + + + G  S+HLA  E     ++
Sbjct: 238 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVS 296

Query: 553 LLLSMGCRLS 562
           LLL     +S
Sbjct: 297 LLLGRNANVS 306



 Score =  114 bits (275), Expect = 2e-24
 Identities = 101/416 (24%), Positives = 167/416 (40%), Gaps = 30/416 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 31  MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 90

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 91  SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 148

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 149 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 201

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 202 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 259

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++++ L     +
Sbjct: 260 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL-----T 309

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 310 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 365

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 366 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 417



 Score =  109 bits (261), Expect = 8e-23
 Identities = 102/417 (24%), Positives = 167/417 (40%), Gaps = 31/417 (7%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 7   NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 65

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 66  QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 117

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 118 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 172

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 173 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 230

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 231 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 285

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+ G       LL  +            GLTPLH+A++E    V  +L+N+GA +    
Sbjct: 286 AAQEGHVDMVSLLLGRNANV--------SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 337

Query: 500 N-GRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 338 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 393



 Score =  105 bits (253), Expect = 7e-22
 Identities = 101/366 (27%), Positives = 154/366 (42%), Gaps = 39/366 (10%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G  PLH A     IK +EL L+ GA I        TP+H+A   G ++IV      Q   
Sbjct: 15  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS-----QLMH 69

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A   + +V+  T +H AA     E+V YL+ +G+ +    K+ ++PL ++A       
Sbjct: 70  HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 129

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGR-----LEDFAASCKDHCEKS--------- 388
           V  L++ GA       +    LHL    G       L D  AS     +K          
Sbjct: 130 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 189

Query: 389 ---------LLQLLNEKD---NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                    LLQ     D    +G +PLH A+   + +    L+  GA  +    N  +P
Sbjct: 190 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 249

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH AA+  +   A  LL+        N    +G+  +H+A++EGH  +V LLL R A + 
Sbjct: 250 LHIAAKKNQMDIATTLLEYGADA---NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV- 305

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
              +G  PLHLAA        E+L +  +H +D   K G T LH+         +  LL 
Sbjct: 306 ---SGLTPLHLAAQEDRVNVAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 361

Query: 557 MGCRLS 562
              +++
Sbjct: 362 HSAKVN 367



 Score =  105 bits (252), Expect = 9e-22
 Identities = 106/443 (23%), Positives = 179/443 (40%), Gaps = 33/443 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N   ++  +  +   + A   +G TP+HVA     ++ +  L+      
Sbjct: 15  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 74

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA-IHDHDLCAK 165
           +  N + +  +HMA    +  V++   +  +   V    +  +T LH +A +   D+  +
Sbjct: 75  NTTNVRGETALHMAARSGQAEVVRYLVQDGA--QVEAKAKDDQTPLHISARLGKADIVQQ 132

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L     A       +GY P+H +A+          L  G          +S+   +G  
Sbjct: 133 LL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS--------LSITTKKGFT 182

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G ++   L L+  A          TP+H+A A      V L+   Q    HA
Sbjct: 183 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA-AHYDNQKVALLLLDQGASPHA 241

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
              +      TP+H AA  +  +I   L+  G+D N + ++  + + LAA       V  
Sbjct: 242 AAKN----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSL 297

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L+   A     +++    LHL        ED     +    +     ++ +   G +PLH
Sbjct: 298 LLGRNA-----NVSGLTPLHLAAQ-----EDRVNVAEVLVNQG--AHVDAQTKMGYTPLH 345

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
                G+I+ +  L++  A +N K  N  +PLH AA+ G  H    LL ++      NE 
Sbjct: 346 VGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP---NEL 402

Query: 466 DGEGLTPLHIASREGHTRVVHLL 488
              G T L IA R G+  VV  L
Sbjct: 403 TVNGNTALGIARRLGYISVVDTL 425



 Score =  102 bits (245), Expect = 7e-21
 Identities = 88/350 (25%), Positives = 150/350 (42%), Gaps = 30/350 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG  +  +R  + + +++  +    +T  H ++     +I+  +       NA   +
Sbjct: 88  AARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 146

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH++      D   +LL      S+  +K   P+H+A +  K+ V  +  +  +  
Sbjct: 147 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-- 204

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           + +  G+ G T LH AA +D+   A +L+ D  A       NGY P+H AAK        
Sbjct: 205 SPDAAGKSGLTPLHVAAHYDNQKVA-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 263

Query: 200 VFLQWG-EQRGCTREQMISLY--DNEGNV-----------------PLHSAVHGGDIKAV 239
             L++G +    TR+ + S++    EG+V                 PLH A     +   
Sbjct: 264 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGLTPLHLAAQEDRVNVA 323

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E+ +  GA +  Q     TP+H+ C  G + IV   F +Q   K    T       TP+H
Sbjct: 324 EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN--FLLQHSAKVNAKTK---NGYTPLH 378

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
            AA   H  I+N L+   +  N L     + L + A R G+ +V   +++
Sbjct: 379 QAAQQGHTHIINVLLQNNASPNELTVNGNTALGI-ARRLGYISVVDTLKI 427



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 51/170 (30%), Positives = 78/170 (45%), Gaps = 5/170 (2%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           N K   G +PLH A ++  I+ +E L++ GA I     +  +P+H AA  G  +   QL+
Sbjct: 9   NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 68

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSG 512
                    N ++  G T LH+A+R G   VV  L+  GA +  +  + + PLH++A  G
Sbjct: 69  HHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 125

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
               ++ L        +     G T LHL+  E      A LL  G  LS
Sbjct: 126 KADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 174


>AL359377-1|CAI41372.1| 1071|Homo sapiens ankyrin 3, node of Ranvier
           (ankyrin G) protein.
          Length = 1071

 Score =  150 bits (364), Expect = 3e-35
 Identities = 115/451 (25%), Positives = 189/451 (41%), Gaps = 32/451 (7%)

Query: 74  NAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFA 133
           NAK   G TPLH+A +   +  +E LL+       + E    PIH+A  +  V+++    
Sbjct: 9   NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 68

Query: 134 KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
            + +  + N     G TALH AA        + L+ D  A+ +    +   P+H +A+  
Sbjct: 69  HHGA--SPNTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLG 125

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
            +  ++  LQ G                 G  PLH +   G        L  GA +S   
Sbjct: 126 KADIVQQLLQQGASPNAA--------TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 177

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
               TP+H+A   G L++  L+      +K A   +     +TP+H AA +D+ ++   L
Sbjct: 178 KKGFTPLHVAAKYGKLEVANLLL-----QKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 232

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +++G+  +   K   +PL +AA +       TL+  GAD           +HL    G  
Sbjct: 233 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG-- 290

Query: 374 LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                     H +   L L    + +G +PLH A++E  +   E L+  GA ++ +    
Sbjct: 291 ----------HVDMVSLLLGRNANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 340

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH    YG       LL        +N     G TPLH A+++GHT ++++LL   A
Sbjct: 341 YTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 397

Query: 494 LLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
             +    NG   L +A   GY   ++ L  V
Sbjct: 398 SPNELTVNGNTALGIARRLGYISVVDTLKIV 428



 Score =  121 bits (292), Expect = 1e-26
 Identities = 91/310 (29%), Positives = 144/310 (46%), Gaps = 25/310 (8%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
           TP+H+AC +  + +++L+       KH A + +     +TPIH AA   H  IV+ L++ 
Sbjct: 17  TPLHIACKKNRIKVMELLL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 70

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G+  N  +    + L +AA       V  L++ GA ++ K  + +  LH+    G     
Sbjct: 71  GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----- 125

Query: 377 FAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                K    + LLQ     N    +G +PLH ++REGH      L+  GA +++     
Sbjct: 126 -----KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 180

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH AA+YG+   A  LL          +S   GLTPLH+A+   + +V  LLL++GA
Sbjct: 181 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGA 237

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
             H    NG  PLH+AA          L    +   + + + G  S+HLA  E     ++
Sbjct: 238 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVS 296

Query: 553 LLLSMGCRLS 562
           LLL     +S
Sbjct: 297 LLLGRNANVS 306



 Score =  114 bits (275), Expect = 2e-24
 Identities = 101/416 (24%), Positives = 167/416 (40%), Gaps = 30/416 (7%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 31  MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 90

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 91  SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 148

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 149 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 201

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 202 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 259

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++++ L     +
Sbjct: 260 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL-----T 309

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 310 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 365

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 366 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 417



 Score =  109 bits (261), Expect = 8e-23
 Identities = 102/417 (24%), Positives = 167/417 (40%), Gaps = 31/417 (7%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 7   NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 65

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 66  QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 117

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 118 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 172

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 173 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 230

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 231 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 285

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+ G       LL  +            GLTPLH+A++E    V  +L+N+GA +    
Sbjct: 286 AAQEGHVDMVSLLLGRNANV--------SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 337

Query: 500 N-GRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 338 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 393



 Score =  105 bits (253), Expect = 7e-22
 Identities = 101/366 (27%), Positives = 154/366 (42%), Gaps = 39/366 (10%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G  PLH A     IK +EL L+ GA I        TP+H+A   G ++IV      Q   
Sbjct: 15  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS-----QLMH 69

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A   + +V+  T +H AA     E+V YL+ +G+ +    K+ ++PL ++A       
Sbjct: 70  HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 129

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGR-----LEDFAASCKDHCEKS--------- 388
           V  L++ GA       +    LHL    G       L D  AS     +K          
Sbjct: 130 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 189

Query: 389 ---------LLQLLNEKD---NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                    LLQ     D    +G +PLH A+   + +    L+  GA  +    N  +P
Sbjct: 190 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 249

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH AA+  +   A  LL+        N    +G+  +H+A++EGH  +V LLL R A + 
Sbjct: 250 LHIAAKKNQMDIATTLLEYGADA---NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV- 305

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
              +G  PLHLAA        E+L +  +H +D   K G T LH+         +  LL 
Sbjct: 306 ---SGLTPLHLAAQEDRVNVAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 361

Query: 557 MGCRLS 562
              +++
Sbjct: 362 HSAKVN 367



 Score =  105 bits (252), Expect = 9e-22
 Identities = 106/443 (23%), Positives = 179/443 (40%), Gaps = 33/443 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N   ++  +  +   + A   +G TP+HVA     ++ +  L+      
Sbjct: 15  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 74

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA-IHDHDLCAK 165
           +  N + +  +HMA    +  V++   +  +   V    +  +T LH +A +   D+  +
Sbjct: 75  NTTNVRGETALHMAARSGQAEVVRYLVQDGA--QVEAKAKDDQTPLHISARLGKADIVQQ 132

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L     A       +GY P+H +A+          L  G          +S+   +G  
Sbjct: 133 LL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS--------LSITTKKGFT 182

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G ++   L L+  A          TP+H+A A      V L+   Q    HA
Sbjct: 183 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA-AHYDNQKVALLLLDQGASPHA 241

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
              +      TP+H AA  +  +I   L+  G+D N + ++  + + LAA       V  
Sbjct: 242 AAKN----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSL 297

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L+   A     +++    LHL        ED     +    +     ++ +   G +PLH
Sbjct: 298 LLGRNA-----NVSGLTPLHLAAQ-----EDRVNVAEVLVNQG--AHVDAQTKMGYTPLH 345

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
                G+I+ +  L++  A +N K  N  +PLH AA+ G  H    LL ++      NE 
Sbjct: 346 VGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP---NEL 402

Query: 466 DGEGLTPLHIASREGHTRVVHLL 488
              G T L IA R G+  VV  L
Sbjct: 403 TVNGNTALGIARRLGYISVVDTL 425



 Score =  102 bits (245), Expect = 7e-21
 Identities = 88/350 (25%), Positives = 150/350 (42%), Gaps = 30/350 (8%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG  +  +R  + + +++  +    +T  H ++     +I+  +       NA   +
Sbjct: 88  AARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 146

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH++      D   +LL      S+  +K   P+H+A +  K+ V  +  +  +  
Sbjct: 147 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-- 204

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           + +  G+ G T LH AA +D+   A +L+ D  A       NGY P+H AAK        
Sbjct: 205 SPDAAGKSGLTPLHVAAHYDNQKVA-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 263

Query: 200 VFLQWG-EQRGCTREQMISLY--DNEGNV-----------------PLHSAVHGGDIKAV 239
             L++G +    TR+ + S++    EG+V                 PLH A     +   
Sbjct: 264 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGLTPLHLAAQEDRVNVA 323

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E+ +  GA +  Q     TP+H+ C  G + IV   F +Q   K    T       TP+H
Sbjct: 324 EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN--FLLQHSAKVNAKTK---NGYTPLH 378

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
            AA   H  I+N L+   +  N L     + L + A R G+ +V   +++
Sbjct: 379 QAAQQGHTHIINVLLQNNASPNELTVNGNTALGI-ARRLGYISVVDTLKI 427



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 51/170 (30%), Positives = 78/170 (45%), Gaps = 5/170 (2%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           N K   G +PLH A ++  I+ +E L++ GA I     +  +P+H AA  G  +   QL+
Sbjct: 9   NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 68

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSG 512
                    N ++  G T LH+A+R G   VV  L+  GA +  +  + + PLH++A  G
Sbjct: 69  HHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 125

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
               ++ L        +     G T LHL+  E      A LL  G  LS
Sbjct: 126 KADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 174


>U43965-1|AAB08437.1| 1088|Homo sapiens ankyrin G119 protein.
          Length = 1088

 Score =  149 bits (360), Expect = 8e-35
 Identities = 113/451 (25%), Positives = 191/451 (42%), Gaps = 27/451 (5%)

Query: 74  NAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFA 133
           NAK   G TPLH+A +   +  +E LL+       + E    PIH+A  +  V+++    
Sbjct: 15  NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 74

Query: 134 KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
            + +  + N     G TALH AA        + L+ D  A+ +    +   P+H +A+  
Sbjct: 75  HHGA--SPNTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLG 131

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
            +  ++  LQ G                 G  PLH +   G        L  GA +S   
Sbjct: 132 KADIVQQLLQQGASPNAA--------TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 183

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
               TP+H+A   G L++  L+      +K A   +     +TP+H AA +D+ ++   L
Sbjct: 184 KKGFTPLHVAAKYGKLEVANLLL-----QKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 238

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR 373
           +++G+  +   K   +PL +AA +       TL+  GAD           +HL     G 
Sbjct: 239 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE-GH 297

Query: 374 LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
           ++  +     +        +N  + +G +PLH A++E  +   E L+  GA ++ +    
Sbjct: 298 VDMVSLLLGRNAN------VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 351

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH    YG       LL        +N     G TPLH A+++GHT ++++LL   A
Sbjct: 352 YTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 408

Query: 494 LLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
             +    NG   L +A   GY   ++ L  V
Sbjct: 409 SPNELTVNGNTALGIARRLGYISVVDTLKIV 439



 Score =  129 bits (311), Expect = 7e-29
 Identities = 106/428 (24%), Positives = 191/428 (44%), Gaps = 28/428 (6%)

Query: 116 PIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEW 175
           P+H+A + N++ V+++  K+ +  ++    E G T +H AA   H      L+    A  
Sbjct: 24  PLHIACKKNRIKVMELLLKHGA--SIQAVTESGLTPIHVAAFMGHVNIVSQLMHH-GASP 80

Query: 176 KKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGD 235
                 G   +H AA++  +  +   +Q G Q        +     +   PLH +   G 
Sbjct: 81  NTTNVRGETALHMAARSGQAEVVRYLVQDGAQ--------VEAKAKDDQTPLHISARLGK 132

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
              V+  L+ GA  +       TP+HL+  +G  D+   +      +  A L+    +  
Sbjct: 133 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-----DHGASLSITTKKGF 187

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA +   E+ N L+ + +  +   K   +PL +AA     +    L+  GA    
Sbjct: 188 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 247

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
              N    LH+         D A +  ++   +     N     G + +H A++EGH+  
Sbjct: 248 AAKNGYTPLHIAAKKNQM--DIATTLLEYGADA-----NAVTRQGIASVHLAAQEGHVDM 300

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           +  L+   A +NL N +  +PLH AA+  R + A  L+  ++G   ++     G TPLH+
Sbjct: 301 VSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV--NQGAH-VDAQTKMGYTPLHV 357

Query: 476 ASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
               G+ ++V+ LL   A ++ +  NG  PLH AA  G+T  I +L   ++   +++  +
Sbjct: 358 GCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ-NNASPNELTVN 416

Query: 535 GNTSLHLA 542
           GNT+L +A
Sbjct: 417 GNTALGIA 424



 Score =  128 bits (309), Expect = 1e-28
 Identities = 99/340 (29%), Positives = 157/340 (46%), Gaps = 17/340 (5%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G  PLH A     IK +EL L+ GA I        TP+H+A   G ++IV      Q   
Sbjct: 21  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS-----QLMH 75

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A   + +V+  T +H AA     E+V YL+ +G+ +    K+ ++PL ++A       
Sbjct: 76  HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 135

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           V  L++ GA       +    LHL    G   ED AA   DH   + L +  +K   G +
Sbjct: 136 VQQLLQQGASPNAATTSGYTPLHLSAREGH--EDVAAFLLDH--GASLSITTKK---GFT 188

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           PLH A++ G +     L++  A  +    +  +PLH AA Y     A  LLD        
Sbjct: 189 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 248

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLH 521
            ++   G TPLHIA+++    +   LL  GA  +     G   +HLAA  G+   + LL 
Sbjct: 249 AKN---GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 305

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
             ++++ +  +K G T LHLA  E++ +   +L++ G  +
Sbjct: 306 GRNANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 344



 Score =  122 bits (295), Expect = 6e-27
 Identities = 91/313 (29%), Positives = 146/313 (46%), Gaps = 25/313 (7%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
           TP+H+AC +  + +++L+       KH A + +     +TPIH AA   H  IV+ L++ 
Sbjct: 23  TPLHIACKKNRIKVMELLL------KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 76

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G+  N  +    + L +AA       V  L++ GA ++ K  + +  LH+    G     
Sbjct: 77  GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----- 131

Query: 377 FAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                K    + LLQ     N    +G +PLH ++REGH      L+  GA +++     
Sbjct: 132 -----KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 186

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            +PLH AA+YG+   A  LL          +S   GLTPLH+A+   + +V  LLL++GA
Sbjct: 187 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGA 243

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
             H    NG  PLH+AA          L    +   + + + G  S+HLA  E     ++
Sbjct: 244 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVS 302

Query: 553 LLLSMGCRLSYNN 565
           LLL     ++ +N
Sbjct: 303 LLLGRNANVNLSN 315



 Score =  122 bits (294), Expect = 8e-27
 Identities = 102/416 (24%), Positives = 168/416 (40%), Gaps = 25/416 (6%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           M L L   + +      G T  H A+   + NI+  + ++    N  +  G T LH+A  
Sbjct: 37  MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 96

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  + N     G 
Sbjct: 97  SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA--SPNAATTSGY 154

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH +A   H+  A  L+ D  A        G+ P+H AAK        + LQ      
Sbjct: 155 TPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ------ 207

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +          G  PLH A H  + K   L L  GA       +  TP+H+A  +  +
Sbjct: 208 --KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 265

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           DI   +      E  A   +   Q +  +H AA   H ++V+ L+   +++N  +K   +
Sbjct: 266 DIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 320

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKS 388
           PL LAA          L+  GA +  +       LH+    G  ++ +F      H  K 
Sbjct: 321 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAK- 376

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
               +N K   G +PLH A+++GH   +  L++  A  N    N  + L  A R G
Sbjct: 377 ----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 428



 Score =  116 bits (280), Expect = 4e-25
 Identities = 104/417 (24%), Positives = 171/417 (41%), Gaps = 26/417 (6%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N N    +G T LH A   +     ++L+    A  +    +G  PIH AA       + 
Sbjct: 13  NPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVS 71

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             +  G     T  +        G   LH A   G  + V   ++ GA++  +  D  TP
Sbjct: 72  QLMHHGASPNTTNVR--------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 123

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++   G  DIV+ +   Q    +A  TS      TP+H +A   H ++  +L++ G+ 
Sbjct: 124 LHISARLGKADIVQQLL-QQGASPNAATTS----GYTPLHLSAREGHEDVAAFLLDHGAS 178

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           ++   K+  +PL +AA        + L++  A       +    LH+        +  A 
Sbjct: 179 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVAL 236

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
              D          N     G +PLH A+++  +     L+  GA  N       + +H 
Sbjct: 237 LLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 291

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
           AA+ G       LL  +     +N S+  GLTPLH+A++E    V  +L+N+GA +    
Sbjct: 292 AAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 348

Query: 500 N-GRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             G  PLH+    G  K +  L   HS  ++   K+G T LH A  +     I +LL
Sbjct: 349 KMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 404



 Score =  113 bits (273), Expect = 3e-24
 Identities = 107/443 (24%), Positives = 181/443 (40%), Gaps = 28/443 (6%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G T  H A  +N   ++  +  +   + A   +G TP+HVA     ++ +  L+      
Sbjct: 21  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 80

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA-IHDHDLCAK 165
           +  N + +  +HMA    +  V++   +  +   V    +  +T LH +A +   D+  +
Sbjct: 81  NTTNVRGETALHMAARSGQAEVVRYLVQDGA--QVEAKAKDDQTPLHISARLGKADIVQQ 138

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L     A       +GY P+H +A+          L  G          +S+   +G  
Sbjct: 139 LL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS--------LSITTKKGFT 188

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G ++   L L+  A          TP+H+A A      V L+   Q    HA
Sbjct: 189 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA-AHYDNQKVALLLLDQGASPHA 247

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
              +      TP+H AA  +  +I   L+  G+D N + ++  + + LAA       V  
Sbjct: 248 AAKN----GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSL 303

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L+   A++ L + +    LHL        ED     +    +     ++ +   G +PLH
Sbjct: 304 LLGRNANVNLSNKSGLTPLHLAAQ-----EDRVNVAEVLVNQG--AHVDAQTKMGYTPLH 356

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
                G+I+ +  L++  A +N K  N  +PLH AA+ G  H    LL ++      NE 
Sbjct: 357 VGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP---NEL 413

Query: 466 DGEGLTPLHIASREGHTRVVHLL 488
              G T L IA R G+  VV  L
Sbjct: 414 TVNGNTALGIARRLGYISVVDTL 436



 Score =  107 bits (256), Expect = 3e-22
 Identities = 79/345 (22%), Positives = 146/345 (42%), Gaps = 17/345 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG  +  +R  + + +++  +    +T  H ++     +I+  +       NA   +
Sbjct: 94  AARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 152

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH++      D   +LL      S+  +K   P+H+A +  K+ V  +  +  +  
Sbjct: 153 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-- 210

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           + +  G+ G T LH AA +D+   A +L+ D  A       NGY P+H AAK        
Sbjct: 211 SPDAAGKSGLTPLHVAAHYDNQKVA-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 269

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             L++G        Q        G   +H A   G +  V L L   A ++       TP
Sbjct: 270 TLLEYGADANAVTRQ--------GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 321

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +HLA  +  +++ +++       + A + +      TP+H    + + +IVN+L+   + 
Sbjct: 322 LHLAAQEDRVNVAEVLV-----NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 376

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           +N   K   +PL  AA +     ++ L++  A      +N    L
Sbjct: 377 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 421



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 51/170 (30%), Positives = 78/170 (45%), Gaps = 5/170 (2%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           N K   G +PLH A ++  I+ +E L++ GA I     +  +P+H AA  G  +   QL+
Sbjct: 15  NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 74

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSG 512
                    N ++  G T LH+A+R G   VV  L+  GA +  +  + + PLH++A  G
Sbjct: 75  HHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 131

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
               ++ L        +     G T LHL+  E      A LL  G  LS
Sbjct: 132 KADIVQQLLQ-QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 180



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 33/136 (24%), Positives = 62/136 (45%), Gaps = 3/136 (2%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+VD  + L L   + + + +  G T  H A+  +  N+   + N    ++A+   
Sbjct: 292 AAQEGHVD-MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 350

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHV      +  + +LLQ   + +   +    P+H A +     ++ V  +  +  
Sbjct: 351 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA-- 408

Query: 140 NVNQGGEHGRTALHFA 155
           + N+   +G TAL  A
Sbjct: 409 SPNELTVNGNTALGIA 424



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 1/125 (0%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S K  L+    AA+   V+    + +++ + +  +   G T  H      N  I++
Sbjct: 310 NVNLSNKSGLTPLHLAAQEDRVN-VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 368

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
           F+  ++  +NAK   G TPLH A +      I  LLQ +   + L       + +A  L 
Sbjct: 369 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 428

Query: 125 KVSVL 129
            +SV+
Sbjct: 429 YISVV 433


>BC111761-1|AAI11762.1| 1065|Homo sapiens inversin, isoform a
           protein.
          Length = 1065

 Score =  144 bits (348), Expect = 2e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDQEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>BC112351-1|AAI12352.1|  725|Homo sapiens INVS protein protein.
          Length = 725

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>BC041665-1|AAH41665.1|  604|Homo sapiens Similar to inversin
           protein.
          Length = 604

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL445214-4|CAI39744.1| 1065|Homo sapiens inversin protein.
          Length = 1065

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL445214-3|CAI39745.2|  895|Homo sapiens inversin protein.
          Length = 895

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL356798-2|CAI40807.1| 1065|Homo sapiens inversin protein.
          Length = 1065

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL356798-1|CAI40808.2|  895|Homo sapiens inversin protein.
          Length = 895

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL137072-3|CAH72173.1| 1065|Homo sapiens inversin protein.
          Length = 1065

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AL137072-2|CAM16212.1|  895|Homo sapiens inversin protein.
          Length = 895

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AF084382-2|AAC79457.1|  895|Homo sapiens inversin protein
           alternative isoform protein.
          Length = 895

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AF084382-1|AAC79456.1| 1065|Homo sapiens inversin protein protein.
          Length = 1065

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AF084367-1|AAC79436.1| 1065|Homo sapiens inversin protein protein.
          Length = 1065

 Score =  143 bits (347), Expect = 3e-33
 Identities = 146/597 (24%), Positives = 255/597 (42%), Gaps = 33/597 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+     RL +   +     D  GRT        +  +    +     D+N  D++
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T LH+A +      ++ LL +       + +   P+H+ T       L +  K+ +  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN---ASSR 196
            V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA +   ++  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAANHKDPSAVH 199

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHD 255
           T+   L          E +++  D EG  PLH AV  G++  V+ L       I++  + 
Sbjct: 200 TVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL 254

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  E V   + 
Sbjct: 255 FRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLK 310

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
             S  +  D E R+  + AA +     + T++ L +DI   DIN  +      ++   L 
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGTALHAAALS 367

Query: 376 DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
              ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++L + +  S
Sbjct: 368 GHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS 425

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +L+   A  
Sbjct: 426 LLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
           + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +  +   I 
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALLGERHEVIQ 541

Query: 553 LLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVMALRSD 602
            +L  G        D++A      YK       F +    ++ HEQ  K+  A + +
Sbjct: 542 FMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKRE 598


>AB033049-1|BAA86537.2| 1089|Homo sapiens KIAA1223 protein protein.
          Length = 1089

 Score =  143 bits (347), Expect = 3e-33
 Identities = 139/574 (24%), Positives = 249/574 (43%), Gaps = 46/574 (8%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + ++L +   + +   D R      QA  R ++ I   ++N A  +N  D+ G T L  A
Sbjct: 155 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS-IRTLLDNGAS-VNQCDSNGRTLLANA 212

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             + +LD +  L+ +  +  + +     P+ +A       V+       +  N+N   + 
Sbjct: 213 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQD 270

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TAL  AA   H      L+              Y  +     +A SRT+     WG  
Sbjct: 271 GWTALRSAAWGGHTEVVSALL--------------YAGVKVDCADADSRTVLRAAAWGGH 316

Query: 208 RGCTREQM-----ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                  +     ++  DNEG   L +A + G  + VE  L  GA+++ +  D  T + +
Sbjct: 317 EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 376

Query: 263 AC-----AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           A      ++G   +V L+     +  H     CD   MTP+  AA   H ++V+ L+  G
Sbjct: 377 AALCVPASKGHASVVSLLIDRGAEVDH-----CDKDGMTPLLVAAYEGHVDVVDLLLEGG 431

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           +D++  D   R+PLL AAS      V+TL+  GA +   D   R VL +    G      
Sbjct: 432 ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN----- 486

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
               +   ++ L +  N +D+ G +PLH A+ EGH    E LI  GA  N  +N+   P 
Sbjct: 487 VEVVRTLLDRGLDE--NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 544

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH- 496
             A++ G +     LL++      I++   +G   L +A+ EGH  +V LL + GA ++ 
Sbjct: 545 ILASQEGHYDCVQILLENKSN---IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 601

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
           +D +GR  L++ A+       E      ++ ++  D +G T+LH++  +     + +L++
Sbjct: 602 KDADGRPTLYILALENQLTMAEYFLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIA 660

Query: 557 MGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
               + + +N   SA+  A +    +    ++ H
Sbjct: 661 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 694



 Score =  120 bits (289), Expect = 3e-26
 Identities = 129/539 (23%), Positives = 221/539 (41%), Gaps = 35/539 (6%)

Query: 27  DDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHV 86
           +D +R  L   + +   D  GRT    A+   + ++++ + +   DL  +D  G+TPL +
Sbjct: 185 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 244

Query: 87  AVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE 146
           A        +  L+      +  ++     +  A       V+     Y  +  V+    
Sbjct: 245 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGV-KVDCADA 302

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
             RT L  AA   H D+   +L     AE  K  N G   +  AA       +E  L  G
Sbjct: 303 DSRTVLRAAAWGGHEDIVLNLL--QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 360

Query: 206 EQRGCTREQMISLYDNEGNVPLHSA-----VHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            +        ++  D +G   L  A        G    V L +  GA++     D  TP+
Sbjct: 361 AE--------VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 412

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
            +A  +G +D+V L+      E  A +   D    TP+  AA   H  +VN L+  G+ +
Sbjct: 413 LVAAYEGHVDVVDLLL-----EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 467

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAAS 380
           + +D E R+ L +A+++     V TL+  G D   +D      LH+    G RL      
Sbjct: 468 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL-----I 522

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
           C+   E+      NE DN G  P   AS+EGH   ++ L+   + I+ +  +  + L  A
Sbjct: 523 CEALIEQG--ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 580

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDH 499
           A  G      +LL S      +N  D +G   L+I + E    +    L  GA +   D 
Sbjct: 581 ALEGH-RDIVELLFSHGAD--VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 637

Query: 500 NGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            GR  LH++   G+ + +++L + H+  ++  D +  ++L  A  +     + LL+  G
Sbjct: 638 EGRTALHVSCWQGHMEMVQVLIAYHAD-VNAADNEKRSALQSAAWQGHVKVVQLLIEHG 695



 Score =  107 bits (257), Expect = 2e-22
 Identities = 120/525 (22%), Positives = 209/525 (39%), Gaps = 36/525 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA  G  +D +   L   + +   D  GRTA   A+   +  I+  + ++  ++N +D
Sbjct: 308 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 367

Query: 78  NAGNTPLHVAV-----ENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
             G T L VA             +  L+ +  E    ++    P+ +A     V V+ + 
Sbjct: 368 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 427

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            +  +  +V+    +GRT L  AA   H      L+    A      + G   +  A+  
Sbjct: 428 LEGGA--DVDHTDNNGRTPLLAAASMGHASVVNTLLF-WGAAVDSIDSEGRTVLSIASAQ 484

Query: 193 ASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ 252
            +   +   L     RG          D+ G  PLH A   G     E  +  GA+ +  
Sbjct: 485 GNVEVVRTLLD----RGLDENHR----DDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 536

Query: 253 QHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            +D   P  LA  +G  D V+++      E  + +          +  AA+  H +IV  
Sbjct: 537 DNDGRIPFILASQEGHYDCVQILL-----ENKSNIDQRGYDGRNALRVAALEGHRDIVEL 591

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L + G+D+N  D + R  L + A           +  GA+++  D   R  LH+    G 
Sbjct: 592 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG- 650

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            +E        H +      +N  DN   S L  A+ +GH++ ++ LI  GA ++   N 
Sbjct: 651 HMEMVQVLIAYHAD------VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ 704

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             + L  AA+ G       LL+        N +D  G T + +A++ GH++++ LL   G
Sbjct: 705 GATALCIAAQEGHIDVVQVLLEHGADP---NHADQFGRTAMRVAAKNGHSQIIKLLEKYG 761

Query: 493 ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           A      NG +P  +  M    K ++ L S    L  + +  G+T
Sbjct: 762 A---SSLNGCSPSPVHTME--QKPLQSLSSKVQSLTIKSNSSGST 801


>BX640674-1|CAE45806.1| 1280|Homo sapiens hypothetical protein
           protein.
          Length = 1280

 Score =  142 bits (344), Expect = 7e-33
 Identities = 140/571 (24%), Positives = 252/571 (44%), Gaps = 40/571 (7%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + ++L +   + +   D R      QA  R ++ I   ++N A  +N  D+ G T L  A
Sbjct: 346 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS-IRTLLDNGAS-VNQCDSNGRTLLANA 403

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             + +LD +  L+ +  +  + +     P+ +A       V+       +  N+N   + 
Sbjct: 404 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQD 461

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNG--YYPIHEAAKNASSRTIEVFLQWG 205
           G TAL  AA   H    +++   L A  K  C +      +  AA       +   LQ G
Sbjct: 462 GWTALRSAAWGGH---TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 518

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC- 264
            +        ++  DNEG   L +A + G  + VE  L  GA+++ +  D  T + +A  
Sbjct: 519 AE--------VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAAL 570

Query: 265 ----AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
               ++G   +V L+     +  H     CD   MTP+  AA   H ++V+ L+  G+D+
Sbjct: 571 CVPASKGHASVVSLLIDRGAEVDH-----CDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 625

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAAS 380
           +  D   R+PLL AAS      V+TL+  GA +   D   R VL +    G         
Sbjct: 626 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN-----VEV 680

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
            +   ++ L +  N +D+ G +PLH A+ EGH    E LI  GA  N  +N+   P   A
Sbjct: 681 VRTLLDRGLDE--NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 738

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDH 499
           ++ G +     LL++      I++   +G   L +A+ EGH  +V LL + GA ++ +D 
Sbjct: 739 SQEGHYDCVQILLENKSN---IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 795

Query: 500 NGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGC 559
           +GR  L++ A+       E      ++ ++  D +G T+LH++  +     + +L++   
Sbjct: 796 DGRPTLYILALENQLTMAEYFLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 854

Query: 560 RL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            + + +N   SA+  A +    +    ++ H
Sbjct: 855 DVNAADNEKRSALQSAAWQGHVKVVQLLIEH 885



 Score =  122 bits (293), Expect = 1e-26
 Identities = 130/539 (24%), Positives = 222/539 (41%), Gaps = 35/539 (6%)

Query: 27  DDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHV 86
           +D +R  L   + +   D  GRT    A+   + ++++ + +   DL  +D  G+TPL +
Sbjct: 376 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 435

Query: 87  AVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE 146
           A        +  L+      +  ++     +  A       V+     Y  +  V+    
Sbjct: 436 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGV-KVDCADA 493

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
             RTAL  AA   H D+   +L     AE  K  N G   +  AA       +E  L  G
Sbjct: 494 DSRTALRAAAWGGHEDIVLNLL--QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 551

Query: 206 EQRGCTREQMISLYDNEGNVPLHSA-----VHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            +        ++  D +G   L  A        G    V L +  GA++     D  TP+
Sbjct: 552 AE--------VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 603

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
            +A  +G +D+V L+      E  A +   D    TP+  AA   H  +VN L+  G+ +
Sbjct: 604 LVAAYEGHVDVVDLLL-----EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 658

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAAS 380
           + +D E R+ L +A+++     V TL+  G D   +D      LH+    G RL      
Sbjct: 659 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL-----I 713

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
           C+   E+      NE DN G  P   AS+EGH   ++ L+   + I+ +  +  + L  A
Sbjct: 714 CEALIEQG--ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 771

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDH 499
           A  G      +LL S      +N  D +G   L+I + E    +    L  GA +   D 
Sbjct: 772 ALEGH-RDIVELLFSHGAD--VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 828

Query: 500 NGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            GR  LH++   G+ + +++L + H+  ++  D +  ++L  A  +     + LL+  G
Sbjct: 829 EGRTALHVSCWQGHMEMVQVLIAYHAD-VNAADNEKRSALQSAAWQGHVKVVQLLIEHG 886



 Score =  107 bits (257), Expect = 2e-22
 Identities = 120/525 (22%), Positives = 209/525 (39%), Gaps = 36/525 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA  G  +D +   L   + +   D  GRTA   A+   +  I+  + ++  ++N +D
Sbjct: 499 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 558

Query: 78  NAGNTPLHVAV-----ENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
             G T L VA             +  L+ +  E    ++    P+ +A     V V+ + 
Sbjct: 559 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 618

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            +  +  +V+    +GRT L  AA   H      L+    A      + G   +  A+  
Sbjct: 619 LEGGA--DVDHTDNNGRTPLLAAASMGHASVVNTLLF-WGAAVDSIDSEGRTVLSIASAQ 675

Query: 193 ASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ 252
            +   +   L     RG          D+ G  PLH A   G     E  +  GA+ +  
Sbjct: 676 GNVEVVRTLLD----RGLDENHR----DDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 727

Query: 253 QHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            +D   P  LA  +G  D V+++      E  + +          +  AA+  H +IV  
Sbjct: 728 DNDGRIPFILASQEGHYDCVQILL-----ENKSNIDQRGYDGRNALRVAALEGHRDIVEL 782

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L + G+D+N  D + R  L + A           +  GA+++  D   R  LH+    G 
Sbjct: 783 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG- 841

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            +E        H +      +N  DN   S L  A+ +GH++ ++ LI  GA ++   N 
Sbjct: 842 HMEMVQVLIAYHAD------VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ 895

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             + L  AA+ G       LL+        N +D  G T + +A++ GH++++ LL   G
Sbjct: 896 GATALCIAAQEGHIDVVQVLLEHGADP---NHADQFGRTAMRVAAKNGHSQIIKLLEKYG 952

Query: 493 ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           A      NG +P  +  M    K ++ L S    L  + +  G+T
Sbjct: 953 A---SSLNGCSPSPVHTME--QKPLQSLSSKVQSLTIKSNSSGST 992


>AK127496-1|BAC87007.1| 1375|Homo sapiens protein ( Homo sapiens
           cDNA FLJ45589 fis, clone BRTHA3014547, weakly  similar
           to Ankyrin 1. ).
          Length = 1375

 Score =  142 bits (344), Expect = 7e-33
 Identities = 139/574 (24%), Positives = 249/574 (43%), Gaps = 46/574 (8%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + ++L +   + +   D R      QA  R ++ I   ++N A  +N  D+ G T L  A
Sbjct: 441 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS-IRTLLDNGAS-VNQCDSNGRTLLANA 498

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             + +LD +  L+ +  +  + +     P+ +A       V+       +  N+N   + 
Sbjct: 499 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQD 556

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TAL  AA   H      L+              Y  +     +A SRT      WG +
Sbjct: 557 GWTALRSAAWGGHTEVVSALL--------------YAGVKVDCADADSRTALRAAAWGGR 602

Query: 208 RGCTREQM-----ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                  +     ++  DNEG   L +A + G  + VE  L  GA+++ +  D  T + +
Sbjct: 603 EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 662

Query: 263 AC-----AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           A      ++G   +V L+     +  H     CD   MTP+  AA   H ++V+ L+  G
Sbjct: 663 AALCVPASKGHASVVSLLIDRGAEVDH-----CDKDGMTPLLVAAYEGHVDVVDLLLEGG 717

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           +D++  D   R+PLL AAS      V+TL+  GA +   D   R VL +    G      
Sbjct: 718 ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN----- 772

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
               +   ++ L +  N +D+ G +PLH A+ EGH    E LI  GA  N  +N+   P 
Sbjct: 773 VEVVRTLLDRGLDE--NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 830

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH- 496
             A++ G +     LL++      I++   +G   L +A+ EGH  +V LL + GA ++ 
Sbjct: 831 ILASQEGHYDCVQILLENKSN---IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 887

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
           +D +GR  L++ A+       E      ++ ++  D +G T+LH++  +     + +L++
Sbjct: 888 KDADGRPTLYILALENQLTMAEYFLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIA 946

Query: 557 MGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
               + + +N   SA+  A +    +    ++ H
Sbjct: 947 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 980



 Score =  118 bits (285), Expect = 9e-26
 Identities = 129/539 (23%), Positives = 221/539 (41%), Gaps = 35/539 (6%)

Query: 27  DDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHV 86
           +D +R  L   + +   D  GRT    A+   + ++++ + +   DL  +D  G+TPL +
Sbjct: 471 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 530

Query: 87  AVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE 146
           A        +  L+      +  ++     +  A       V+     Y  +  V+    
Sbjct: 531 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGV-KVDCADA 588

Query: 147 HGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
             RTAL  AA     D+   +L     AE  K  N G   +  AA       +E  L  G
Sbjct: 589 DSRTALRAAAWGGREDIVLNLL--QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 646

Query: 206 EQRGCTREQMISLYDNEGNVPLHSA-----VHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            +        ++  D +G   L  A        G    V L +  GA++     D  TP+
Sbjct: 647 AE--------VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 698

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
            +A  +G +D+V L+      E  A +   D    TP+  AA   H  +VN L+  G+ +
Sbjct: 699 LVAAYEGHVDVVDLLL-----EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 753

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAAS 380
           + +D E R+ L +A+++     V TL+  G D   +D      LH+    G RL      
Sbjct: 754 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL-----I 808

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
           C+   E+      NE DN G  P   AS+EGH   ++ L+   + I+ +  +  + L  A
Sbjct: 809 CEALIEQG--ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA 866

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDH 499
           A  G      +LL S      +N  D +G   L+I + E    +    L  GA +   D 
Sbjct: 867 ALEGH-RDIVELLFSHGAD--VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 923

Query: 500 NGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            GR  LH++   G+ + +++L + H+  ++  D +  ++L  A  +     + LL+  G
Sbjct: 924 EGRTALHVSCWQGHMEMVQVLIAYHAD-VNAADNEKRSALQSAAWQGHVKVVQLLIEHG 981



 Score =  107 bits (257), Expect = 2e-22
 Identities = 120/525 (22%), Positives = 209/525 (39%), Gaps = 36/525 (6%)

Query: 18   VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
            ++AA  G  +D +   L   + +   D  GRTA   A+   +  I+  + ++  ++N +D
Sbjct: 594  LRAAAWGGREDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 653

Query: 78   NAGNTPLHVAV-----ENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
              G T L VA             +  L+ +  E    ++    P+ +A     V V+ + 
Sbjct: 654  VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 713

Query: 133  AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
             +  +  +V+    +GRT L  AA   H      L+    A      + G   +  A+  
Sbjct: 714  LEGGA--DVDHTDNNGRTPLLAAASMGHASVVNTLLF-WGAAVDSIDSEGRTVLSIASAQ 770

Query: 193  ASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ 252
             +   +   L     RG          D+ G  PLH A   G     E  +  GA+ +  
Sbjct: 771  GNVEVVRTLLD----RGLDENHR----DDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 822

Query: 253  QHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
             +D   P  LA  +G  D V+++      E  + +          +  AA+  H +IV  
Sbjct: 823  DNDGRIPFILASQEGHYDCVQILL-----ENKSNIDQRGYDGRNALRVAALEGHRDIVEL 877

Query: 313  LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
            L + G+D+N  D + R  L + A           +  GA+++  D   R  LH+    G 
Sbjct: 878  LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG- 936

Query: 373  RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
             +E        H +      +N  DN   S L  A+ +GH++ ++ LI  GA ++   N 
Sbjct: 937  HMEMVQVLIAYHAD------VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ 990

Query: 433  NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              + L  AA+ G       LL+        N +D  G T + +A++ GH++++ LL   G
Sbjct: 991  GATALCIAAQEGHIDVVQVLLEHGADP---NHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1047

Query: 493  ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
            A      NG +P  +  M    K ++ L S    L  + +  G+T
Sbjct: 1048 A---SSLNGCSPSPVHTME--QKPLQSLSSKVQSLTIKSNSSGST 1087


>AF039217-1|AAD02131.2| 1013|Homo sapiens inv candidate homolog
           protein.
          Length = 1013

 Score =  139 bits (336), Expect = 6e-32
 Identities = 137/545 (25%), Positives = 239/545 (43%), Gaps = 33/545 (6%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D+N  D++  T LH+A +      ++ LL +       + +   P+H+ T       L +
Sbjct: 21  DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 80

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
             K+ +   V+   ++ +TALH++A +++    K+LI   D+    P   G  P+H AA 
Sbjct: 81  LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH-DSNIGIPDVEGKIPLHWAAN 139

Query: 192 N---ASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGA 247
           +   ++  T+   L          E +++  D EG  PLH AV  G++  V+ L      
Sbjct: 140 HKDPSAVHTVRCILD-----AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 194

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHP 307
            I++  +   TP+H A   G   IV L+     + K   + S D Q  TP+H AA  +  
Sbjct: 195 NITSYDNLFRTPLHWAALLGHAQIVHLLL---ERNKSGTIPS-DSQGATPLHYAAQSNFA 250

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E V   +   S  +  D E R+  + AA +     + T++ L +DI   DIN  +     
Sbjct: 251 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI---DINMADKYGGT 307

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
            ++   L    ++ K   E +    ++  D    +PL  A   GH   ++ LI+ GA ++
Sbjct: 308 ALHAAALSGHVSTVKLLLENN--AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD 365

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHL 487
           L + +  S LH+AA  G     CQ+L  +K     N  D  G TPL  A+  G+   + +
Sbjct: 366 LVDQDGHSLLHWAALGGN-ADVCQILIENK--INPNVQDYAGRTPLQCAAYGGYINCMAV 422

Query: 488 LLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATM 544
           L+   A  + +D  GR  LH +  +GY   I+LL   +   + ++  +++  T L  A +
Sbjct: 423 LMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN-NEERYTPLDYALL 481

Query: 545 ENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK-------FPEAALAMVTHEQRAKEVM 597
             +   I  +L  G        D++A      YK       F +    ++ HEQ  K+  
Sbjct: 482 GERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAA 541

Query: 598 ALRSD 602
           A + +
Sbjct: 542 AKKRE 546



 Score =  108 bits (259), Expect = 1e-22
 Identities = 85/325 (26%), Positives = 148/325 (45%), Gaps = 13/325 (4%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
           +   +  L++GA ++   H   T +HLA  +G    +KL+ T     + A     D+++M
Sbjct: 9   LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLT-----RRANWMQKDLEEM 63

Query: 296 TPIHCAAMFDHPEIVNYLIN--EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           TP+H       P+ +  L+      +++  DK +++ L  +A       V  LI+  ++I
Sbjct: 64  TPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNI 123

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
            + D+  +  LH    +          C      +   LLN +D  G +PLH+A  +G++
Sbjct: 124 GIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT-ESLLNWQDYEGRTPLHFAVADGNV 182

Query: 414 RSLENLIRLGAC-INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
             ++ L    +C I   +N   +PLH+AA  G       LL+ +K   I   SD +G TP
Sbjct: 183 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI--PSDSQGATP 240

Query: 473 LHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
           LH A++      V + L   ++    D  GR     AA  G    +  + S+ S + ++ 
Sbjct: 241 LHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 300

Query: 531 IDKDGNTSLHLATMENKPSSIALLL 555
            DK G T+LH A +    S++ LLL
Sbjct: 301 ADKYGGTALHAAALSGHVSTVKLLL 325



 Score =  101 bits (243), Expect = 1e-20
 Identities = 125/496 (25%), Positives = 213/496 (42%), Gaps = 54/496 (10%)

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
           A  K+  +VN+     RTALH AA   +    K+L+T   A W +       P+H   ++
Sbjct: 14  ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLT-RRANWMQKDLEEMTPLHLTTRH 72

Query: 193 ASSRTIEVFLQW---GEQRGCTREQMISLY------------------------DNEGNV 225
            S + + + L++   GE     + +  +L+                        D EG +
Sbjct: 73  RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 132

Query: 226 PLHSAVHGGDIKAVEL--CLRSGAK----ISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           PLH A +  D  AV    C+   A     ++ Q ++  TP+H A A G + +V ++ + +
Sbjct: 133 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 192

Query: 280 PKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEG-SDINPLDKERRSPLLLAASR 337
                +C +TS D    TP+H AA+  H +IV+ L+    S   P D +  +PL  AA  
Sbjct: 193 -----SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQS 247

Query: 338 AGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
               TV   ++  +     D+  R         G   +D   +      KS +  +N  D
Sbjct: 248 NFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS--DDVLRTMLS--LKSDID-INMAD 302

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
             G + LH A+  GH+ +++ L+   A ++  +    +PL  A   G       L+   K
Sbjct: 303 KYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLI---K 359

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLL-NRGALLHRDHNGRNPLHLAAMSGYTKT 516
           G   ++  D +G + LH A+  G+  V  +L+ N+     +D+ GR PL  AA  GY   
Sbjct: 360 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINC 419

Query: 517 IELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGC---RLSYNNMDMSAIDY 573
           + +L   ++    Q DK+G T+LH +       +I LLL       ++  N    + +DY
Sbjct: 420 MAVLMENNADPNIQ-DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDY 478

Query: 574 AIYYKFPEAALAMVTH 589
           A+  +  E    M+ H
Sbjct: 479 ALLGERHEVIQFMLEH 494



 Score = 99.5 bits (237), Expect = 6e-20
 Identities = 106/483 (21%), Positives = 193/483 (39%), Gaps = 29/483 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA--GDLNAKD 77
           AA+ GN   FM+L L+  +    +D    T  H  +   +   L  +  +   G+++ +D
Sbjct: 36  AAQKGNYR-FMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 94

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF----- 132
               T LH +      + ++ L++      + + + + P+H A      S +        
Sbjct: 95  KNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILD 154

Query: 133 -AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
            A  +SL N       GRT LHFA    +     +L +          N    P+H AA 
Sbjct: 155 AAPTESLLNWQD--YEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 212

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
              ++ + + L+  +             D++G  PLH A      + V++ L+  +    
Sbjct: 213 LGHAQIVHLLLERNKSGTIPS-------DSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 265

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN 311
              +  T    A  +G+ D+++ M +++       +   D    T +H AA+  H   V 
Sbjct: 266 SDLEGRTSFMWAAGKGSDDVLRTMLSLK---SDIDINMADKYGGTALHAAALSGHVSTVK 322

Query: 312 YLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            L+   + ++  D  + +PL  A        + TLI+ GA + L D +  ++LH   + G
Sbjct: 323 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 382

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
                 A  C+   E  +    N +D  G +PL  A+  G+I  +  L+   A  N+++ 
Sbjct: 383 N-----ADVCQILIENKINP--NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 435

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              + LH++   G       LLD       + E++ E  TPL  A       V+  +L  
Sbjct: 436 EGRTALHWSCNNGYLDAIKLLLDFAAFPNQM-ENNEERYTPLDYALLGERHEVIQFMLEH 494

Query: 492 GAL 494
           GAL
Sbjct: 495 GAL 497



 Score = 88.6 bits (210), Expect = 1e-16
 Identities = 68/264 (25%), Positives = 123/264 (46%), Gaps = 13/264 (4%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           ++C  + D  +  + L+  G+D+N  D  +R+ L LAA +  +R +  L+   A+   KD
Sbjct: 1   MYCV-LADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKD 59

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ-LLNEKDNTGCSPLHYASREGHIRSL 416
           +     LHL   +       +  C     K +    ++ +D    + LH+++   +   +
Sbjct: 60  LEEMTPLHLTTRHR------SPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHV 113

Query: 417 ENLIRLGACINLKNNNNESPLHFAARY---GRFHTACQLLDSDKGTFIINESDGEGLTPL 473
           + LI+  + I + +   + PLH+AA +      HT   +LD+     ++N  D EG TPL
Sbjct: 114 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPL 173

Query: 474 HIASREGHTRVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
           H A  +G+  VV +L +  +  +   D+  R PLH AA+ G+ + + LL   +       
Sbjct: 174 HFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS 233

Query: 532 DKDGNTSLHLATMENKPSSIALLL 555
           D  G T LH A   N   ++ + L
Sbjct: 234 DSQGATPLHYAAQSNFAETVKVFL 257



 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 118/492 (23%), Positives = 192/492 (39%), Gaps = 41/492 (8%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D   RTA H A+ + N   +  +     +   KD    TPLH+   + +   +  LL+  
Sbjct: 26  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 85

Query: 104 V--ETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHD 161
              E    ++  Q  +H +   N    +++  K+ S  N+      G+  LH+AA H   
Sbjct: 86  APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDS--NIGIPDVEGKIPLHWAANHKDP 143

Query: 162 LCAKILITDLDAEWKKPCNN-----GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
                +   LDA   +   N     G  P+H A  + +   ++V   +     C     I
Sbjct: 144 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY---ESCN----I 196

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCL---RSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           + YDN    PLH A   G  + V L L   +SG   S  Q   +TP+H A      + VK
Sbjct: 197 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG--ATPLHYAAQSNFAETVK 254

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS--DINPLDKERRSPL 331
            +F   P  K       D++  T    AA     +++  +++  S  DIN  DK   + L
Sbjct: 255 -VFLKHPSVK----DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL 309

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
             AA      TV  L+   A +   D+     L      G + +      K      L+ 
Sbjct: 310 HAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHK-DVIQTLIKGGARVDLV- 367

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
                D  G S LH+A+  G+    + LI      N+++    +PL  AA  G  +    
Sbjct: 368 -----DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 422

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR---NPLHLA 508
           L++++      N  D EG T LH +   G+   + LLL+  A  ++  N      PL  A
Sbjct: 423 LMENNADP---NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 479

Query: 509 AMSGYTKTIELL 520
            +    + I+ +
Sbjct: 480 LLGERHEVIQFM 491


>AY367056-1|AAQ72374.1|  520|Homo sapiens KIAA0379-like protein
           protein.
          Length = 520

 Score =  134 bits (325), Expect = 1e-30
 Identities = 119/427 (27%), Positives = 188/427 (44%), Gaps = 28/427 (6%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H AA +   + +EV +Q            + + ++ G  PL  A   G ++ V++ + 
Sbjct: 20  PLHLAAYHGHHQALEVLVQ--------SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 71

Query: 245 SGAKISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
            GA I  + + L  TP+H A   G  + ++L+  +   E    +   D    TP+  + +
Sbjct: 72  QGASILVKDYILKRTPIHAAATNGHSECLRLL--IGNAEPQNAVDIQDGNGQTPLMLSVL 129

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
             H + V  L+N+G++++  DK  R+ L   A       V  L++ GA   L+D   R  
Sbjct: 130 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 189

Query: 364 LHLVVMNG-----GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLEN 418
           +HL    G     G L   AAS   +   +        DN G + LH+A   GH   +E 
Sbjct: 190 IHLSAACGHIGVLGALLQSAASMDANPATA--------DNHGYTALHWACYNGHETCVEL 241

Query: 419 LIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR 478
           L+           N  SPLH A        A  L+D+  G  I+N +D +G TPLH A+ 
Sbjct: 242 LLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDT-LGASIVNATDSKGRTPLHAAAF 299

Query: 479 EGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
             H   + LLL+  A ++  D  G+ PL +AA +G T T+E+L S  S  L   D   NT
Sbjct: 300 TDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNT 359

Query: 538 SLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVTHEQRAKEVM 597
           +LHLA  +   +S  L+L      +  N   +A+   ++       L MV  E   K   
Sbjct: 360 ALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA-ARNGLTMVVQELLGKGAS 418

Query: 598 ALRSDRH 604
            L  D +
Sbjct: 419 VLAVDEN 425



 Score =  111 bits (268), Expect = 1e-23
 Identities = 116/455 (25%), Positives = 191/455 (41%), Gaps = 28/455 (6%)

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILIT 169
           N    +P+H+A        L+V  +  SL +++     GRT L  AA   H  C  +LI 
Sbjct: 14  NRATISPLHLAAYHGHHQALEVLVQ--SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 71

Query: 170 DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHS 229
              +   K       PIH AA N  S  + + +   E +       + + D  G  PL  
Sbjct: 72  QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA-----VDIQDGNGQTPLML 126

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           +V  G    V   L  GA +  +     T +H     G  + V  +     K    CL  
Sbjct: 127 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK----CLLR 182

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGS--DINPLDKERRSPLLLA-ASRAGWRTVHTL 346
            D +  TPIH +A   H  ++  L+   +  D NP   +      L  A   G  T   L
Sbjct: 183 -DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVEL 241

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +      Q  + N+ + LH  V+N    E  A    D    S++   N  D+ G +PLH 
Sbjct: 242 LLEQEVFQKTEGNAFSPLHCAVINDN--EGAAEMLIDTLGASIV---NATDSKGRTPLHA 296

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+   H+  L+ L+   A +N  ++  ++PL  AA  G+ +T   L+ S      + ++ 
Sbjct: 297 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 356

Query: 467 GEGLTPLHIASREGHTRVVHLLL----NRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS 522
               T LH+A  +GH     L+L    +R  +   +   + PLH+AA +G T  ++ L  
Sbjct: 357 KN--TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLG 414

Query: 523 VHSHLLDQIDKDGNT-SLHLATMENKPSSIALLLS 556
             + +L  +D++G T +L  A  ++    +AL+L+
Sbjct: 415 KGASVL-AVDENGYTPALACAPNKDVADCLALILA 448



 Score =  111 bits (267), Expect = 1e-23
 Identities = 117/443 (26%), Positives = 184/443 (41%), Gaps = 33/443 (7%)

Query: 73  LNAKDNAGN-TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           L+  DN    +PLH+A  +    A+E L+Q  ++  V N   + P+ +A     V  + V
Sbjct: 9   LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 68

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCN--NGYYPIHEA 189
                +   V       RT +H AA + H  C ++LI + + +        NG  P+  +
Sbjct: 69  LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 127

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
             N  +  +   L  G          +   D  G   LH     G  + V+  L+ GAK 
Sbjct: 128 VLNGHTDCVYSLLNKGAN--------VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 179

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
             +     TP+HL+ A G + ++  +         A   + D    T +H A    H   
Sbjct: 180 LLRDSRGRTPIHLSAACGHIGVLGALL-QSAASMDANPATADNHGYTALHWACYNGHETC 238

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVV 368
           V  L+ E       +    SPL  A           LI  LGA I    +N+ +      
Sbjct: 239 VELLL-EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI----VNATD------ 287

Query: 369 MNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLG 423
            + GR    AA+  DH E   L L     +N  D+TG +PL  A+  G   ++E L+   
Sbjct: 288 -SKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 346

Query: 424 AC-INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           +  + L++N+  + LH A   G   +A  +L+      +IN ++    TPLH+A+R G T
Sbjct: 347 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 406

Query: 483 RVVHLLLNRGA-LLHRDHNGRNP 504
            VV  LL +GA +L  D NG  P
Sbjct: 407 MVVQELLGKGASVLAVDENGYTP 429



 Score =  105 bits (253), Expect = 7e-22
 Identities = 98/402 (24%), Positives = 168/402 (41%), Gaps = 20/402 (4%)

Query: 40  LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA-GNTPLHVAVENEALDAIEY 98
           L VR+  GRT    A+ + +   +  + N    +  KD     TP+H A  N   + +  
Sbjct: 43  LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 102

Query: 99  LL---QQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFA 155
           L+   +      + +   Q P+ M + LN  +   V++      NV+   + GRTALH  
Sbjct: 103 LIGNAEPQNAVDIQDGNGQTPL-MLSVLNGHTDC-VYSLLNKGANVDAKDKWGRTALHRG 160

Query: 156 AIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQM 215
           A+  H+ C   L+    A+     + G  PIH +A       +   LQ       + +  
Sbjct: 161 AVTGHEECVDALLQH-GAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ----SAASMDAN 215

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
            +  DN G   LH A + G    VEL L       T+ +  S P+H A         +++
Sbjct: 216 PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEML 274

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                    + + + D +  TP+H AA  DH E +  L++  + +N +D   ++PL++AA
Sbjct: 275 IDTLGA---SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 331

Query: 336 SRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
                 TV  L+    A++ L+D +    LHL    G          +   +++L+   N
Sbjct: 332 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI-LEKITDRNLINATN 390

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
               T   PLH A+R G    ++ L+  GA +   + N  +P
Sbjct: 391 AALQT---PLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 429



 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 103/437 (23%), Positives = 180/437 (41%), Gaps = 45/437 (10%)

Query: 52  HQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNE 111
           H A+   +   L  +     DL+ ++++G TPL +A     ++ ++ L+ Q     V + 
Sbjct: 22  HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 81

Query: 112 KC-QAPIHMATELNKVSVLQVF---AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              + PIH A        L++    A+ ++  ++  G  +G+T L  + ++ H  C   L
Sbjct: 82  ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG--NGQTPLMLSVLNGHTDCVYSL 139

Query: 168 I---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGN 224
           +    ++DA+ K     G   +H  A       ++  LQ G +  C       L D+ G 
Sbjct: 140 LNKGANVDAKDKW----GRTALHRGAVTGHEECVDALLQHGAK--CL------LRDSRGR 187

Query: 225 VPLHSAVHGGDIKAVELCLRSGAKI----STQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
            P+H +   G I  +   L+S A +    +T  +   T +H AC  G    V+L+   + 
Sbjct: 188 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 247

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE--GSDINPLDKERRSPLLLAASRA 338
            +K       +    +P+HCA + D+      LI+    S +N  D + R+PL  AA   
Sbjct: 248 FQK------TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTD 301

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDN 398
               +  L+   A +   D   +  L +   NG        +  +    S    L  +DN
Sbjct: 302 HVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG------QTNTVEMLVSSASAELTLQDN 355

Query: 399 TGCSPLHYASREGHIRSLENLIRLGACINLKNNNN---ESPLHFAARYGRFHTACQLLDS 455
           +  + LH A  +GH  S   ++      NL N  N   ++PLH AAR G      +LL  
Sbjct: 356 SKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGK 415

Query: 456 DKGTFIINESDGEGLTP 472
                 ++E+   G TP
Sbjct: 416 GASVLAVDEN---GYTP 429



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 68/319 (21%), Positives = 140/319 (43%), Gaps = 20/319 (6%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNT 82
           +G+ D    L L++ + +  +D  GRTA H+ +   +   +  +  +      +D+ G T
Sbjct: 130 NGHTDCVYSL-LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 188

Query: 83  PLHVAVENEALDAIEYLLQ----QHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           P+H++     +  +  LLQ         +  +      +H A      + +++  + + +
Sbjct: 189 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE-QEV 247

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN-GYYPIHEAAKNASSRT 197
           F   +G  +  + LH A I+D++  A++LI  L A      ++ G  P+H AA       
Sbjct: 248 FQKTEG--NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 305

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS-GAKISTQQHDL 256
           +++ L    Q        ++  D+ G  PL  A   G    VE+ + S  A+++ Q +  
Sbjct: 306 LQLLLSHNAQ--------VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 357

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
           +T +HLAC++G       +  ++       + + +    TP+H AA      +V  L+ +
Sbjct: 358 NTALHLACSKG--HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGK 415

Query: 317 GSDINPLDKERRSPLLLAA 335
           G+ +  +D+   +P L  A
Sbjct: 416 GASVLAVDENGYTPALACA 434



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD---LN 74
           + AAE+G  +    L  S  + L ++D    TA H A ++ +      I     D   +N
Sbjct: 328 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 387

Query: 75  AKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAP 116
           A + A  TPLHVA  N     ++ LL +      ++E    P
Sbjct: 388 ATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 429


>BC063622-1|AAH63622.1|  367|Homo sapiens ANKRD44 protein protein.
          Length = 367

 Score =  134 bits (323), Expect = 2e-30
 Identities = 102/347 (29%), Positives = 170/347 (48%), Gaps = 22/347 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           ++  D+E   PLH A   GD + +EL + SGA+++ + +   TP+H A A  + + V+++
Sbjct: 34  VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 93

Query: 276 FTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
                  KH+  + + D    TP+H AA     +    +I   S +N  D+  R+ L  A
Sbjct: 94  I------KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHA 147

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           A       V+ L+  GA+I   D   R  LH     G    D  A   +H  +     + 
Sbjct: 148 ALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHL--DVVALLINHGAE-----VT 200

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            KD  G +PLH A+  G I  +++L+ LG  I+  N    + LH A   G+     +L+D
Sbjct: 201 CKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 260

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRV-VHLLLNRGALLH-RDHNGRNPLHLAAMSG 512
                  +N+ +  G TPLH A+   H  + + LL+N GA ++ +  +G++PLH+ A+ G
Sbjct: 261 YGAN---VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 317

Query: 513 -YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            +T++  L+ +     +D +DKDGNT LH+A        I  L++ G
Sbjct: 318 RFTRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTLITSG 362



 Score =  130 bits (314), Expect = 3e-29
 Identities = 98/356 (27%), Positives = 166/356 (46%), Gaps = 27/356 (7%)

Query: 140 NVNQGGEHGRTALHFAA-IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           +VN      RT LH AA + D ++   ++++      K   N    P+H A  + S   +
Sbjct: 33  DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD--NMWLTPLHRAVASRSEEAV 90

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +V ++            ++  D     PLH A     +K  E+ +   + ++       T
Sbjct: 91  QVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRT 142

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
            +H A   G +++V L+       K A + + D +    +H AA   H ++V  LIN G+
Sbjct: 143 ALHHAALNGHVEMVNLLLA-----KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 197

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           ++   DK+  +PL  AAS      V  L+ LG +I   ++     LH+   NG   +   
Sbjct: 198 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ--DAVV 255

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH-IRSLENLIRLGACINLKNNNNESPL 437
               D+        +N+ +N G +PLH+A+   H    LE L+  GA +N+++ + +SPL
Sbjct: 256 NELIDYGAN-----VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 310

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           H  A +GRF T  Q L  + G   I+  D +G TPLH+A+R GH  +++ L+  GA
Sbjct: 311 HMTAVHGRF-TRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTLITSGA 363



 Score =  125 bits (302), Expect = 8e-28
 Identities = 96/358 (26%), Positives = 159/358 (44%), Gaps = 18/358 (5%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           VQA  SG+ ++ +R+ + +   +   D   RT  H A+   +  I+  +      +NAKD
Sbjct: 13  VQAIFSGDPEE-IRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD 71

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           N   TPLH AV + + +A++ L++   + +  ++  Q P+H+A     V   +V     S
Sbjct: 72  NMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 131

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             NV+  G  GRTALH AA++ H     +L+    A            +H AA       
Sbjct: 132 SVNVSDRG--GRTALHHAALNGHVEMVNLLLAK-GANINAFDKKDRRALHWAAYMGHLDV 188

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           + + +  G +  C         D +G  PLH+A   G I  V+  L  G +I       +
Sbjct: 189 VALLINHGAEVTCK--------DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGN 240

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI-VNYLINE 316
           T +H+AC  G   +V  +      +  A +   +    TP+H AA   H  + +  L+N 
Sbjct: 241 TALHIACYNGQDAVVNELI-----DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 295

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           G+D+N   K+ +SPL + A    +    TLI+ G +I   D +    LH+    G  L
Sbjct: 296 GADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 353



 Score =  122 bits (293), Expect = 1e-26
 Identities = 101/340 (29%), Positives = 157/340 (46%), Gaps = 29/340 (8%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H AA    +  IE+ +  G +        ++  DN    PLH AV     +AV++ ++
Sbjct: 44  PLHVAAFLGDAEIIELLILSGAR--------VNAKDNMWLTPLHRAVASRSEEAVQVLIK 95

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
             A ++ +  +  TP+H+A A  A+   +++  +      + +   D    T +H AA+ 
Sbjct: 96  HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLL-----SSVNVSDRGGRTALHHAALN 150

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
            H E+VN L+ +G++IN  DK+ R  L  AA       V  LI  GA++  KD      L
Sbjct: 151 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 210

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           H    NG          + +  K LL L   ++E +  G + LH A   G    +  LI 
Sbjct: 211 HAAASNG----------QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 260

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
            GA +N  NNN  +PLHFAA         +LL ++     I   DG+  +PLH+ +  G 
Sbjct: 261 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGK--SPLHMTAVHGR 318

Query: 482 -TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
            TR   L+ N G +   D +G  PLH+AA  G+   I  L
Sbjct: 319 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 358



 Score =  118 bits (283), Expect = 2e-25
 Identities = 93/335 (27%), Positives = 160/335 (47%), Gaps = 18/335 (5%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD + + + +     ++T   +  TP+H+A   G  +I++L+         A
Sbjct: 11  PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLIL-----SGA 65

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + + D   +TP+H A      E V  LI   +D+N  DK  ++PL +AA+    +    
Sbjct: 66  RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEV 125

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           +I L + + + D   R  LH   +N G +E          + + +   ++KD      LH
Sbjct: 126 IIPLLSSVNVSDRGGRTALHHAALN-GHVEMVNLLL---AKGANINAFDKKDRRA---LH 178

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
           +A+  GH+  +  LI  GA +  K+    +PLH AA  G+ +    LL+       I+E 
Sbjct: 179 WAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG---VEIDEI 235

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGY-TKTIELLHSV 523
           +  G T LHIA   G   VV+ L++ GA +++ ++NG  PLH AA S +    +ELL + 
Sbjct: 236 NVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 295

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            + +  Q  KDG + LH+  +  + +    L+  G
Sbjct: 296 GADVNIQ-SKDGKSPLHMTAVHGRFTRSQTLIQNG 329



 Score =  106 bits (255), Expect = 4e-22
 Identities = 84/280 (30%), Positives = 131/280 (46%), Gaps = 13/280 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  A     PE +  LI++  D+N LD E+R+PL +AA       +  LI  GA +  K
Sbjct: 11  PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK 70

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D      LH  V    R E+       H        +N +D    +PLH A+    ++  
Sbjct: 71  DNMWLTPLHRAV--ASRSEEAVQVLIKHSAD-----VNARDKNWQTPLHVAAANKAVKCA 123

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           E +I L + +N+ +    + LH AA  G       LL   KG   IN  D +    LH A
Sbjct: 124 EVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL--AKGA-NINAFDKKDRRALHWA 180

Query: 477 SREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
           +  GH  VV LL+N GA +  +D  G  PLH AA +G    ++ L ++    +D+I+  G
Sbjct: 181 AYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE-IDEINVYG 239

Query: 536 NTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYA 574
           NT+LH+A    + + +  L+  G  ++  NN   + + +A
Sbjct: 240 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 279



 Score =  102 bits (244), Expect = 9e-21
 Identities = 86/327 (26%), Positives = 144/327 (44%), Gaps = 19/327 (5%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           + + L +   +R+  +D    T  H+A A  +   +  +  ++ D+NA+D    TPLHVA
Sbjct: 55  EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVA 114

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
             N+A+   E ++      +V +   +  +H A     V ++ +     +  N+N   + 
Sbjct: 115 AANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA--NINAFDKK 172

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
            R ALH+AA   H L    L+ +  AE       GY P+H AA N     ++  L  G +
Sbjct: 173 DRRALHWAAYMGH-LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 231

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQ- 266
                   I++Y   GN  LH A + G    V   +  GA ++   ++  TP+H A A  
Sbjct: 232 I-----DEINVY---GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 283

Query: 267 -GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
            GAL +  L+         A +        +P+H  A+         LI  G +I+ +DK
Sbjct: 284 HGALCLELLV------NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 337

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +  +PL +AA       ++TLI  GAD
Sbjct: 338 DGNTPLHVAARYGHELLINTLITSGAD 364


>BC110618-1|AAI10619.1|  784|Homo sapiens receptor-interacting
           serine-threonine kinase 4 protein.
          Length = 784

 Score =  124 bits (300), Expect = 1e-27
 Identities = 98/354 (27%), Positives = 161/354 (45%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+       +   + + D  + T +H AA          L+ + + +N +D E R+P+ +
Sbjct: 489 LLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 602

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 603 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G   +     +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 658 HRGAGKEAVT---SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 715 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 83/313 (26%), Positives = 135/313 (43%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 470 RGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ + + P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 639

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV-----EEKA 694

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 754 LLRHGAHINLQSL 766



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 16/292 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           + L L+    +  +D    TA H A+   + +    +      +N  D  G TP+HVA +
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 546

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + +  LL++ V+ S+  +    P+H A     + ++++ AK   + +VN     GR
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV-SVNAQTLDGR 605

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH AA   H   A+ILI DL ++          P+H AA+   + T  + L     RG
Sbjct: 606 TPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL----HRG 660

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +E + S    +G   LH A   G +  V+L +   A +  +     T +HLA A G  
Sbjct: 661 AGKEAVTS----DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           ++V+ + +         +   D Q ++ +H AA   H + V  L+  G+ IN
Sbjct: 717 EVVEELVSAD------VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 96/384 (25%), Positives = 154/384 (40%), Gaps = 29/384 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 452

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            AK+  L N N       G T LH A         ++L+    +   K   + +  +H A
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD-EDQWTALHFA 511

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  +
Sbjct: 512 AQNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  +
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
              LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL   
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAAR 679

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L 
Sbjct: 680 N-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDLF 731

Query: 430 NNNNESPLHFAARYGRFHTACQLL 453
           +    S LH AA+     T   LL
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETLL 755



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 487

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
            LLL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGRTPMHVACQ 546

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKD 569


>BC110617-1|AAI10618.1|  784|Homo sapiens receptor-interacting
           serine-threonine kinase 4 protein.
          Length = 784

 Score =  124 bits (300), Expect = 1e-27
 Identities = 98/354 (27%), Positives = 161/354 (45%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+       +   + + D  + T +H AA          L+ + + +N +D E R+P+ +
Sbjct: 489 LLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 602

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 603 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G   +     +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 658 HRGAGKEAVT---SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 715 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 83/313 (26%), Positives = 135/313 (43%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 470 RGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ + + P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 639

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV-----EEKA 694

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 754 LLRHGAHINLQSL 766



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 16/292 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           + L L+    +  +D    TA H A+   + +    +      +N  D  G TP+HVA +
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 546

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + +  LL++ V+ S+  +    P+H A     + ++++ AK   + +VN     GR
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV-SVNAQTLDGR 605

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH AA   H   A+ILI DL ++          P+H AA+   + T  + L     RG
Sbjct: 606 TPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL----HRG 660

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +E + S    +G   LH A   G +  V+L +   A +  +     T +HLA A G  
Sbjct: 661 AGKEAVTS----DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           ++V+ + +         +   D Q ++ +H AA   H + V  L+  G+ IN
Sbjct: 717 EVVEELVSAD------VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 96/384 (25%), Positives = 154/384 (40%), Gaps = 29/384 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 452

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            AK+  L N N       G T LH A         ++L+    +   K   + +  +H A
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD-EDQWTALHFA 511

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  +
Sbjct: 512 AQNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  +
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
              LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL   
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAAR 679

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L 
Sbjct: 680 N-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDLF 731

Query: 430 NNNNESPLHFAARYGRFHTACQLL 453
           +    S LH AA+     T   LL
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETLL 755



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 487

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
            LLL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGRTPMHVACQ 546

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKD 569


>BC050586-1|AAH50586.2|  306|Homo sapiens ANKRD44 protein protein.
          Length = 306

 Score =  124 bits (300), Expect = 1e-27
 Identities = 89/315 (28%), Positives = 149/315 (47%), Gaps = 34/315 (10%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A  + S   ++V ++            ++  D     PLH A     +K  E+ + 
Sbjct: 16  PLHRAVASRSEEAVQVLIKHSAD--------VNARDKNWQTPLHVAAANKAVKCAEVIIP 67

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
             + ++       T +H A   G +++V L+       K A + + D +    +H AA  
Sbjct: 68  LLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA-----KGANINAFDKKDRRALHWAAYM 122

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
            H ++V  LIN G+++   DK+  +PL  AAS      V  L+ LG +I   ++     L
Sbjct: 123 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 182

Query: 365 HLVVMNG-----GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH-IRSLEN 418
           H+   NG       L D+ A+            +N+ +N G +PLH+A+   H    LE 
Sbjct: 183 HIACYNGQDAVVNELIDYGAN------------VNQPNNNGFTPLHFAAASTHGALCLEL 230

Query: 419 LIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR 478
           L+  GA +N+++ + +SPLH  A +GRF T  Q L  + G   I+  D +G TPLH+A+R
Sbjct: 231 LVNNGADVNIQSKDGKSPLHMTAVHGRF-TRSQTLIQNGGE--IDCVDKDGNTPLHVAAR 287

Query: 479 EGHTRVVHLLLNRGA 493
            GH  +++ L+  GA
Sbjct: 288 YGHELLINTLITSGA 302



 Score =  113 bits (273), Expect = 3e-24
 Identities = 92/318 (28%), Positives = 154/318 (48%), Gaps = 22/318 (6%)

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC-LTSCDVQKMTPIHCAAM 303
           SGA+++ + +   TP+H A A  + + V+++       KH+  + + D    TP+H AA 
Sbjct: 2   SGARVNAKDNMWLTPLHRAVASRSEEAVQVLI------KHSADVNARDKNWQTPLHVAAA 55

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
               +    +I   S +N  D+  R+ L  AA       V+ L+  GA+I   D   R  
Sbjct: 56  NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA 115

Query: 364 LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLG 423
           LH     G    D  A   +H  +     +  KD  G +PLH A+  G I  +++L+ LG
Sbjct: 116 LHWAAYMGHL--DVVALLINHGAE-----VTCKDKKGYTPLHAAASNGQINVVKHLLNLG 168

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTR 483
             I+  N    + LH A   G+     +L+D       +N+ +  G TPLH A+   H  
Sbjct: 169 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN---VNQPNNNGFTPLHFAAASTHGA 225

Query: 484 V-VHLLLNRGALLH-RDHNGRNPLHLAAMSG-YTKTIELLHSVHSHLLDQIDKDGNTSLH 540
           + + LL+N GA ++ +  +G++PLH+ A+ G +T++  L+ +     +D +DKDGNT LH
Sbjct: 226 LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE--IDCVDKDGNTPLH 283

Query: 541 LATMENKPSSIALLLSMG 558
           +A        I  L++ G
Sbjct: 284 VAARYGHELLINTLITSG 301



 Score =  112 bits (270), Expect = 6e-24
 Identities = 84/303 (27%), Positives = 135/303 (44%), Gaps = 17/303 (5%)

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +NAKDN   TPLH AV + + +A++ L++   + +  ++  Q P+H+A     V   +V 
Sbjct: 6   VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 65

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
               S  NV+  G  GRTALH AA++ H     +L+    A            +H AA  
Sbjct: 66  IPLLSSVNVSDRG--GRTALHHAALNGHVEMVNLLLAK-GANINAFDKKDRRALHWAAYM 122

Query: 193 ASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ 252
                + + +  G +  C         D +G  PLH+A   G I  V+  L  G +I   
Sbjct: 123 GHLDVVALLINHGAEVTCK--------DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI 174

Query: 253 QHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI-VN 311
               +T +H+AC  G   +V  +      +  A +   +    TP+H AA   H  + + 
Sbjct: 175 NVYGNTALHIACYNGQDAVVNELI-----DYGANVNQPNNNGFTPLHFAAASTHGALCLE 229

Query: 312 YLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            L+N G+D+N   K+ +SPL + A    +    TLI+ G +I   D +    LH+    G
Sbjct: 230 LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYG 289

Query: 372 GRL 374
             L
Sbjct: 290 HEL 292



 Score =  100 bits (240), Expect = 3e-20
 Identities = 85/317 (26%), Positives = 139/317 (43%), Gaps = 19/317 (5%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  +D    T  H+A A  +   +  +  ++ D+NA+D    TPLHVA  N+A+   E
Sbjct: 4   ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAE 63

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            ++      +V +   +  +H A     V ++ +     +  N+N   +  R ALH+AA 
Sbjct: 64  VIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA--NINAFDKKDRRALHWAAY 121

Query: 158 HDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMIS 217
             H L    L+ +  AE       GY P+H AA N     ++  L  G          I+
Sbjct: 122 MGH-LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG-----VEIDEIN 175

Query: 218 LYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA--QGALDIVKLM 275
           +Y   GN  LH A + G    V   +  GA ++   ++  TP+H A A   GAL +  L+
Sbjct: 176 VY---GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLV 232

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                    A +        +P+H  A+         LI  G +I+ +DK+  +PL +AA
Sbjct: 233 ------NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 286

Query: 336 SRAGWRTVHTLIRLGAD 352
                  ++TLI  GAD
Sbjct: 287 RYGHELLINTLITSGAD 303



 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 64/229 (27%), Positives = 109/229 (47%), Gaps = 13/229 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G+V+  + L L++ + +   D + R A H A+   + +++  + N+  ++  KD  
Sbjct: 86  AALNGHVE-MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 144

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH A  N  ++ +++LL   VE   +N      +H+A    + +V+     Y +  
Sbjct: 145 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA-- 202

Query: 140 NVNQGGEHGRTALHFAAIHDHD-LCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVNQ   +G T LHFAA   H  LC ++L+ +  A+      +G  P+H  A +      
Sbjct: 203 NVNQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRS 261

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +  +Q G +  C         D +GN PLH A   G    +   + SGA
Sbjct: 262 QTLIQNGGEIDCV--------DKDGNTPLHVAARYGHELLINTLITSGA 302



 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 69/253 (27%), Positives = 112/253 (44%), Gaps = 13/253 (5%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G+ +N  D    +PL  A +      V  LI+  AD+  +D N +  LH+   N      
Sbjct: 3   GARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANK----- 57

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
            A  C +     LL  +N  D  G + LH+A+  GH+  +  L+  GA IN  +  +   
Sbjct: 58  -AVKCAE-VIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA 115

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           LH+AA  G       L++       +   D +G TPLH A+  G   VV  LLN G  + 
Sbjct: 116 LHWAAYMGHLDVVALLINHGAE---VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID 172

Query: 497 R-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS-SIALL 554
             +  G   LH+A  +G    +  L    ++ ++Q + +G T LH A      +  + LL
Sbjct: 173 EINVYGNTALHIACYNGQDAVVNELIDYGAN-VNQPNNNGFTPLHFAAASTHGALCLELL 231

Query: 555 LSMGCRLSYNNMD 567
           ++ G  ++  + D
Sbjct: 232 VNNGADVNIQSKD 244



 Score = 80.6 bits (190), Expect = 3e-14
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 6/186 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N KDN   +PLH A       +++ LI+  A +N ++ N ++PLH AA       A  +
Sbjct: 6   VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 65

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMS 511
           +        +N SD  G T LH A+  GH  +V+LLL +GA ++  D   R  LH AA  
Sbjct: 66  IPLLSS---VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYM 122

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM-DMSA 570
           G+   + LL + H   +   DK G T LH A    + + +  LL++G  +   N+   +A
Sbjct: 123 GHLDVVALLIN-HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTA 181

Query: 571 IDYAIY 576
           +  A Y
Sbjct: 182 LHIACY 187



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 68/302 (22%), Positives = 126/302 (41%), Gaps = 21/302 (6%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +   ++ +++ +   + +  RD   +T  H A+A         I      +N  D  G
Sbjct: 20  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 79

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            T LH A  N  ++ +  LL +    +  ++K +  +H A  +  + V+ +   + +   
Sbjct: 80  RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA--E 137

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           V    + G T LH AA +      K L+ +L  E  +    G   +H A  N     +  
Sbjct: 138 VTCKDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDAVVNE 196

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLH---SAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            + +G          ++  +N G  PLH   ++ HG     +EL + +GA ++ Q  D  
Sbjct: 197 LIDYGAN--------VNQPNNNGFTPLHFAAASTHGA--LCLELLVNNGADVNIQSKDGK 246

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           +P+H+    G     +    +Q   +  C+   D    TP+H AA + H  ++N LI  G
Sbjct: 247 SPLHMTAVHGR--FTRSQTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTLITSG 301

Query: 318 SD 319
           +D
Sbjct: 302 AD 303


>AL359707-2|CAC78760.1| 1166|Homo sapiens tankyrase,
           TRF1-interacting ankyrin-related ADP-ribose polymerase 2
           protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AJ278016-1|CAC04247.1|  784|Homo sapiens protein kinase protein.
          Length = 784

 Score =  124 bits (300), Expect = 1e-27
 Identities = 98/354 (27%), Positives = 161/354 (45%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+       +   + + D  + T +H AA          L+ + + +N +D E R+P+ +
Sbjct: 489 LLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 602

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 603 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G   +     +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 658 HRGAGKKAVT---SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 715 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 83/313 (26%), Positives = 135/313 (43%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 470 RGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ + + P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 639

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALHLAARNGHLATVKLLV-----EEKA 694

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 754 LLRHGAHINLQSL 766



 Score = 92.7 bits (220), Expect = 7e-18
 Identities = 75/292 (25%), Positives = 131/292 (44%), Gaps = 16/292 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           + L L+    +  +D    TA H A+   + +    +      +N  D  G TP+HVA +
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 546

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + +  LL++ V+ S+  +    P+H A     + ++++ AK   + +VN     GR
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV-SVNAQTLDGR 605

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH AA   H   A+ILI DL ++          P+H AA+   + T  + L     RG
Sbjct: 606 TPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL----HRG 660

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             ++ + S    +G   LH A   G +  V+L +   A +  +     T +HLA A G  
Sbjct: 661 AGKKAVTS----DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           ++V+ + +         +   D Q ++ +H AA   H + V  L+  G+ IN
Sbjct: 717 EVVEELVSAD------VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 89.0 bits (211), Expect = 9e-17
 Identities = 96/384 (25%), Positives = 154/384 (40%), Gaps = 29/384 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 452

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            AK+  L N N       G T LH A         ++L+    +   K   + +  +H A
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD-EDQWTALHFA 511

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  +
Sbjct: 512 AQNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  +
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
              LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL   
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALHLAAR 679

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L 
Sbjct: 680 N-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDLF 731

Query: 430 NNNNESPLHFAARYGRFHTACQLL 453
           +    S LH AA+     T   LL
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETLL 755



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 487

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
            LLL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGRTPMHVACQ 546

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKD 569


>AF438201-1|AAL40795.1| 1166|Homo sapiens tankyrase II protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AF342982-1|AAK25811.1| 1166|Homo sapiens tankyrase 2 protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AF329696-1|AAK13463.1| 1166|Homo sapiens tankyrase 2 protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AF309033-1|AAK82330.1| 1166|Homo sapiens tankyrase-2 protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AF264912-1|AAG44694.1| 1166|Homo sapiens tankyrase-like protein
           protein.
          Length = 1166

 Score =  124 bits (300), Expect = 1e-27
 Identities = 146/590 (24%), Positives = 248/590 (42%), Gaps = 57/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 30  EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 150 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 193

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 194 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 247 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTV-HTLIRLGADIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +    H+L++   +  +  I     L +V    
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 476

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 477 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 441

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 442 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 484

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 545 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 659

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 720 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 777 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 837 AASSLD-NLSGSFSELSSV 854



 Score =  106 bits (255), Expect = 4e-22
 Identities = 130/522 (24%), Positives = 216/522 (41%), Gaps = 54/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+K       + + +AA+ A    
Sbjct: 302 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFKG------HSLLQAAREADVTR 346

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L        + E +   +       LH A      K  ++C   LR GA I+ +  
Sbjct: 347 IKKHL--------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 454 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 505

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 506 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 559 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 616 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 655



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 28  LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-----QNG 81

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 82  ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 262 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 392 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 503

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 504 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 561

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 562 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 614 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKG 756



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 31/301 (10%)

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE 386
           + +PL  AA       V  L++ GA++Q +D      LH    + G  E      +   +
Sbjct: 58  KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC-SFGHAEVVNLLLRHGAD 116

Query: 387 KSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF 446
                  N +DN   +PLH A+ +G I     L++ GA   ++N +  + L  A    + 
Sbjct: 117 P------NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKA 170

Query: 447 -----HTACQLLDS------DKGTFII-------NESDGEGLTPLHIASREGHTRVVHLL 488
                +   +LL+S      +K   ++       + SDG   TPLH+A+     ++V LL
Sbjct: 171 VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLL 230

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
           L  GA +H +D     PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQFTPLHEAASKNR 289

Query: 548 PSSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPE-AALAMVTHE--QRAKEVMALRSDR 603
               +LLLS G   +  N  + SAID A   +  E  A     H   Q A+E    R  +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 604 H 604
           H
Sbjct: 350 H 350



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 53  DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 112

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 113 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 166

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 167 SAKAVLTGEYKKDELL 182



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 781

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 782 LDLVSADD 789


>AB047783-1|BAB56136.1|  784|Homo sapiens probable dual-specificity
           Ser/Thr/Tyr kinase protein.
          Length = 784

 Score =  124 bits (300), Expect = 1e-27
 Identities = 98/354 (27%), Positives = 161/354 (45%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+       +   + + D  + T +H AA          L+ + + +N +D E R+P+ +
Sbjct: 489 LLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 602

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 603 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G   +     +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 658 HRGAGKEAVT---SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 715 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 83/313 (26%), Positives = 135/313 (43%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 470 RGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ + + P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 639

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV-----EEKA 694

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 754 LLRHGAHINLQSL 766



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 16/292 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           + L L+    +  +D    TA H A+   + +    +      +N  D  G TP+HVA +
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 546

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + +  LL++ V+ S+  +    P+H A     + ++++ AK   + +VN     GR
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV-SVNAQTLDGR 605

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH AA   H   A+ILI DL ++          P+H AA+   + T  + L     RG
Sbjct: 606 TPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL----HRG 660

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +E + S    +G   LH A   G +  V+L +   A +  +     T +HLA A G  
Sbjct: 661 AGKEAVTS----DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           ++V+ + +         +   D Q ++ +H AA   H + V  L+  G+ IN
Sbjct: 717 EVVEELVSAD------VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 96/384 (25%), Positives = 154/384 (40%), Gaps = 29/384 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 452

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            AK+  L N N       G T LH A         ++L+    +   K   + +  +H A
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD-EDQWTALHFA 511

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  +
Sbjct: 512 AQNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  +
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
              LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL   
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAAR 679

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L 
Sbjct: 680 N-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDLF 731

Query: 430 NNNNESPLHFAARYGRFHTACQLL 453
           +    S LH AA+     T   LL
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETLL 755



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 487

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
            LLL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGRTPMHVACQ 546

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKD 569


>AJ541797-1|CAD62569.2|  765|Homo sapiens ankyrin repeat and kinase
           domain containing 1 protein.
          Length = 765

 Score =  124 bits (299), Expect = 2e-27
 Identities = 112/411 (27%), Positives = 176/411 (42%), Gaps = 28/411 (6%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQW 204
           E+  T LHF          ++L+  ++D + +    +GY P+  AA++       + L  
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA--SGYTPLLIAAQDQQPDLCALLLAH 417

Query: 205 GEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC 264
           G           +  D +G  PLH A   GD     L L  GA +  Q+ +  TP+HLA 
Sbjct: 418 GADA--------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469

Query: 265 AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                ++ +L+ + Q     A     + +  TP+H AA F H  +V  L ++G++++   
Sbjct: 470 QNNFENVARLLVSRQ-----ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524

Query: 325 KERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDH 384
           +  R+PL LA  R   R +  L++ GA     D +    LH     G  L      CK  
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL-----ICKML 579

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
                   L    + G +PLH A+ +GH+  +  L    A +      N +PLH AAR+G
Sbjct: 580 LRYG--ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIA-SREGHTRVVHLLLNRGALLHRDHNGRN 503
                  LL         N ++  G TPLH+A  R     V++LL +   +  R+  G  
Sbjct: 638 EEAVVSALLQCGADP---NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
           P HLAA+ G T  +++L    +  LD  D    T L LA    K   ++ L
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQ-LDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  111 bits (266), Expect = 2e-23
 Identities = 100/386 (25%), Positives = 162/386 (41%), Gaps = 24/386 (6%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           G+V+  +RL L+    +  +   G T    A+     ++   +  +  D N  D  G  P
Sbjct: 373 GSVEQ-VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A +N        LL           +   P+H+A + N  +V ++    ++  N+++
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQ 203
               G+T LH AA   H    K L+T   AE      N   P+H A +    R I+  L+
Sbjct: 492 A--EGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 204 WGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
            G         +    D  G  PLH+A   G     ++ LR GA +    H   TP+HLA
Sbjct: 549 SG--------AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 264 CAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPL 323
             +G L+I+ L+      E HA + +      TP+H AA      +V+ L+  G+D N  
Sbjct: 601 AYKGHLEIIHLL-----AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKD 383
           ++   +PL LA  R+ + +V  L+   A++  ++       HL  + G       A  K 
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN-----TAILKV 710

Query: 384 HCEKSLLQLLNEKDNTGCSPLHYASR 409
             E      L+ +D   C+PL  A R
Sbjct: 711 LVEAG--AQLDVQDGVSCTPLQLALR 734



 Score =  103 bits (247), Expect = 4e-21
 Identities = 92/394 (23%), Positives = 171/394 (43%), Gaps = 23/394 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H   A+ +   +  +  +  D++ +  +G TPL +A +++  D    LL    + + 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           ++E   AP+H A +       ++   + +  +  +    G T LH AA ++ +  A++L+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE--REGWTPLHLAAQNNFENVARLLV 481

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
           +   A+       G  P+H AA       +++    G +    +  +          PLH
Sbjct: 482 S-RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL--------RTPLH 532

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            AV  G ++A++  L+SGA           P+H A A+G   I K++         A L 
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-----RYGASLE 587

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
               Q  TP+H AA   H EI++ L    +++  L     +PL LAA       V  L++
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD    + +    LHL V     L     +  +H        ++ ++  G +P H A+
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLS--VINLLEHHAN-----VHARNKVGWTPAHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
            +G+   L+ L+  GA +++++  + +PL  A R
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 82/316 (25%), Positives = 133/316 (42%), Gaps = 19/316 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA++G+ D   RL L   + +  ++  G T  H A+  N  N+   + +   D N  +  
Sbjct: 435 AAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHVA     +  ++ L  Q  E        + P+H+A E  KV  +Q   K  ++ 
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           +      +G   LH AA     L  K+L+    A  + P + G+ P+H AA       I 
Sbjct: 554 DALDQSGYG--PLHTAAARGKYLICKMLLR-YGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           +  +     G                PLH A   G+   V   L+ GA  +  +    TP
Sbjct: 611 LLAESHANMGA--------LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 260 VHLACAQGA-LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           +HLA  +   L ++ L+      E HA + + +    TP H AA+  +  I+  L+  G+
Sbjct: 663 LHLAVQRSTFLSVINLL------EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 319 DINPLDKERRSPLLLA 334
            ++  D    +PL LA
Sbjct: 717 QLDVQDGVSCTPLQLA 732



 Score = 82.6 bits (195), Expect = 8e-15
 Identities = 71/293 (24%), Positives = 122/293 (41%), Gaps = 16/293 (5%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A   N ++  RL +S  +   + +  G+T  H A+   + +++  + +   +L+A+    
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            TPLH+AVE   + AI++LL+       L++    P+H A    K  + ++  +Y +  +
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA--S 585

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           +      G T LH AA   H L    L+ +  A         + P+H AA++     +  
Sbjct: 586 LELPTHQGWTPLHLAAYKGH-LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            LQ G              +  G  PLH AV      +V   L   A +  +     TP 
Sbjct: 645 LLQCGADPNAA--------EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
           HLA  +G   I+K++      E  A L   D    TP+  A       I+++L
Sbjct: 697 HLAALKGNTAILKVLV-----EAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PLH+   +G +  +  L+     ++ +  +  +PL  AA+  +    C LL +      
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-DQQPDLCALLLAHGAD-- 420

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
            N  D +G  PLH A++ G      LLL+ GA +  ++  G  PLHLAA + +     LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            S  +   +  + +G T LH+A      S + LL S G  L
Sbjct: 481 VSRQADP-NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 3/123 (2%)

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           +TPLH    +G    V LLL     +  +  +G  PL +AA         LL + H    
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADA 421

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSAIDYAIYYKFPEAALAMV 587
           +++D+DG   LH A       +  LLL  G C  +      + +  A    F   A  +V
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 588 THE 590
           + +
Sbjct: 482 SRQ 484


>AF525298-1|AAM91924.1|  765|Homo sapiens X-kinase protein.
          Length = 765

 Score =  124 bits (299), Expect = 2e-27
 Identities = 112/411 (27%), Positives = 176/411 (42%), Gaps = 28/411 (6%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQW 204
           E+  T LHF          ++L+  ++D + +    +GY P+  AA++       + L  
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA--SGYTPLLIAAQDQQPDLCALLLAH 417

Query: 205 GEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC 264
           G           +  D +G  PLH A   GD     L L  GA +  Q+ +  TP+HLA 
Sbjct: 418 GADA--------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469

Query: 265 AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                ++ +L+ + Q     A     + +  TP+H AA F H  +V  L ++G++++   
Sbjct: 470 QNNFENVARLLVSRQ-----ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524

Query: 325 KERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDH 384
           +  R+PL LA  R   R +  L++ GA     D +    LH     G  L      CK  
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL-----ICKML 579

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
                   L    + G +PLH A+ +GH+  +  L    A +      N +PLH AAR+G
Sbjct: 580 LRYG--ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIA-SREGHTRVVHLLLNRGALLHRDHNGRN 503
                  LL         N ++  G TPLH+A  R     V++LL +   +  R+  G  
Sbjct: 638 EEAVVSALLQCGADP---NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
           P HLAA+ G T  +++L    +  LD  D    T L LA    K   ++ L
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQ-LDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  111 bits (266), Expect = 2e-23
 Identities = 100/386 (25%), Positives = 162/386 (41%), Gaps = 24/386 (6%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           G+V+  +RL L+    +  +   G T    A+     ++   +  +  D N  D  G  P
Sbjct: 373 GSVEQ-VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A +N        LL           +   P+H+A + N  +V ++    ++  N+++
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQ 203
               G+T LH AA   H    K L+T   AE      N   P+H A +    R I+  L+
Sbjct: 492 A--EGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 204 WGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
            G         +    D  G  PLH+A   G     ++ LR GA +    H   TP+HLA
Sbjct: 549 SG--------AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 264 CAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPL 323
             +G L+I+ L+      E HA + +      TP+H AA      +V+ L+  G+D N  
Sbjct: 601 AYKGHLEIIHLL-----AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKD 383
           ++   +PL LA  R+ + +V  L+   A++  ++       HL  + G       A  K 
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN-----TAILKV 710

Query: 384 HCEKSLLQLLNEKDNTGCSPLHYASR 409
             E      L+ +D   C+PL  A R
Sbjct: 711 LVEAG--AQLDVQDGVSCTPLQLALR 734



 Score =  103 bits (247), Expect = 4e-21
 Identities = 92/394 (23%), Positives = 171/394 (43%), Gaps = 23/394 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H   A+ +   +  +  +  D++ +  +G TPL +A +++  D    LL    + + 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           ++E   AP+H A +       ++   + +  +  +    G T LH AA ++ +  A++L+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE--REGWTPLHLAAQNNFENVARLLV 481

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
           +   A+       G  P+H AA       +++    G +    +  +          PLH
Sbjct: 482 S-RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL--------RTPLH 532

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            AV  G ++A++  L+SGA           P+H A A+G   I K++         A L 
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-----RYGASLE 587

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
               Q  TP+H AA   H EI++ L    +++  L     +PL LAA       V  L++
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD    + +    LHL V     L     +  +H        ++ ++  G +P H A+
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLS--VINLLEHHAN-----VHARNKVGWTPAHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
            +G+   L+ L+  GA +++++  + +PL  A R
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 82/316 (25%), Positives = 133/316 (42%), Gaps = 19/316 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA++G+ D   RL L   + +  ++  G T  H A+  N  N+   + +   D N  +  
Sbjct: 435 AAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHVA     +  ++ L  Q  E        + P+H+A E  KV  +Q   K  ++ 
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           +      +G   LH AA     L  K+L+    A  + P + G+ P+H AA       I 
Sbjct: 554 DALDQSGYG--PLHTAAARGKYLICKMLLR-YGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           +  +     G                PLH A   G+   V   L+ GA  +  +    TP
Sbjct: 611 LLAESHANMGA--------LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 260 VHLACAQGA-LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           +HLA  +   L ++ L+      E HA + + +    TP H AA+  +  I+  L+  G+
Sbjct: 663 LHLAVQRSTFLSVINLL------EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 319 DINPLDKERRSPLLLA 334
            ++  D    +PL LA
Sbjct: 717 QLDVQDGVSCTPLQLA 732



 Score = 82.6 bits (195), Expect = 8e-15
 Identities = 71/293 (24%), Positives = 122/293 (41%), Gaps = 16/293 (5%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A   N ++  RL +S  +   + +  G+T  H A+   + +++  + +   +L+A+    
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            TPLH+AVE   + AI++LL+       L++    P+H A    K  + ++  +Y +  +
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA--S 585

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           +      G T LH AA   H L    L+ +  A         + P+H AA++     +  
Sbjct: 586 LELPTHQGWTPLHLAAYKGH-LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            LQ G              +  G  PLH AV      +V   L   A +  +     TP 
Sbjct: 645 LLQCGADPNAA--------EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
           HLA  +G   I+K++      E  A L   D    TP+  A       I+++L
Sbjct: 697 HLAALKGNTAILKVLV-----EAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PLH+   +G +  +  L+     ++ +  +  +PL  AA+  +    C LL +      
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-DQQPDLCALLLAHGAD-- 420

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
            N  D +G  PLH A++ G      LLL+ GA +  ++  G  PLHLAA + +     LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            S  +   +  + +G T LH+A      S + LL S G  L
Sbjct: 481 VSRQADP-NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 3/123 (2%)

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           +TPLH    +G    V LLL     +  +  +G  PL +AA         LL + H    
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADA 421

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSAIDYAIYYKFPEAALAMV 587
           +++D+DG   LH A       +  LLL  G C  +      + +  A    F   A  +V
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 588 THE 590
           + +
Sbjct: 482 SRQ 484


>AF487542-1|AAQ09005.1|  765|Homo sapiens protein kinase PKK2
           protein.
          Length = 765

 Score =  124 bits (299), Expect = 2e-27
 Identities = 112/411 (27%), Positives = 176/411 (42%), Gaps = 28/411 (6%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQW 204
           E+  T LHF          ++L+  ++D + +    +GY P+  AA++       + L  
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA--SGYTPLLIAAQDQQPDLCALLLAH 417

Query: 205 GEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC 264
           G           +  D +G  PLH A   GD     L L  GA +  Q+ +  TP+HLA 
Sbjct: 418 GADA--------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469

Query: 265 AQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                ++ +L+ + Q     A     + +  TP+H AA F H  +V  L ++G++++   
Sbjct: 470 QNNFENVARLLVSRQ-----ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524

Query: 325 KERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDH 384
           +  R+PL LA  R   R +  L++ GA     D +    LH     G  L      CK  
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL-----ICKML 579

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
                   L    + G +PLH A+ +GH+  +  L    A +      N +PLH AAR+G
Sbjct: 580 LRYG--ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637

Query: 445 RFHTACQLLDSDKGTFIINESDGEGLTPLHIA-SREGHTRVVHLLLNRGALLHRDHNGRN 503
                  LL         N ++  G TPLH+A  R     V++LL +   +  R+  G  
Sbjct: 638 EEAVVSALLQCGADP---NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694

Query: 504 PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
           P HLAA+ G T  +++L    +  LD  D    T L LA    K   ++ L
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQ-LDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  111 bits (266), Expect = 2e-23
 Identities = 100/386 (25%), Positives = 162/386 (41%), Gaps = 24/386 (6%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           G+V+  +RL L+    +  +   G T    A+     ++   +  +  D N  D  G  P
Sbjct: 373 GSVEQ-VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A +N        LL           +   P+H+A + N  +V ++    ++  N+++
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQ 203
               G+T LH AA   H    K L+T   AE      N   P+H A +    R I+  L+
Sbjct: 492 A--EGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 204 WGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
            G         +    D  G  PLH+A   G     ++ LR GA +    H   TP+HLA
Sbjct: 549 SG--------AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 264 CAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPL 323
             +G L+I+ L+      E HA + +      TP+H AA      +V+ L+  G+D N  
Sbjct: 601 AYKGHLEIIHLL-----AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKD 383
           ++   +PL LA  R+ + +V  L+   A++  ++       HL  + G       A  K 
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN-----TAILKV 710

Query: 384 HCEKSLLQLLNEKDNTGCSPLHYASR 409
             E      L+ +D   C+PL  A R
Sbjct: 711 LVEAG--AQLDVQDGVSCTPLQLALR 734



 Score =  103 bits (247), Expect = 4e-21
 Identities = 92/394 (23%), Positives = 171/394 (43%), Gaps = 23/394 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H   A+ +   +  +  +  D++ +  +G TPL +A +++  D    LL    + + 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
           ++E   AP+H A +       ++   + +  +  +    G T LH AA ++ +  A++L+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE--REGWTPLHLAAQNNFENVARLLV 481

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
           +   A+       G  P+H AA       +++    G +    +  +          PLH
Sbjct: 482 S-RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL--------RTPLH 532

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            AV  G ++A++  L+SGA           P+H A A+G   I K++         A L 
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-----RYGASLE 587

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
               Q  TP+H AA   H EI++ L    +++  L     +PL LAA       V  L++
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GAD    + +    LHL V     L     +  +H        ++ ++  G +P H A+
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLS--VINLLEHHAN-----VHARNKVGWTPAHLAA 700

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
            +G+   L+ L+  GA +++++  + +PL  A R
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 82/316 (25%), Positives = 133/316 (42%), Gaps = 19/316 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA++G+ D   RL L   + +  ++  G T  H A+  N  N+   + +   D N  +  
Sbjct: 435 AAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHVA     +  ++ L  Q  E        + P+H+A E  KV  +Q   K  ++ 
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           +      +G   LH AA     L  K+L+    A  + P + G+ P+H AA       I 
Sbjct: 554 DALDQSGYG--PLHTAAARGKYLICKMLLR-YGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           +  +     G                PLH A   G+   V   L+ GA  +  +    TP
Sbjct: 611 LLAESHANMGA--------LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 260 VHLACAQGA-LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           +HLA  +   L ++ L+      E HA + + +    TP H AA+  +  I+  L+  G+
Sbjct: 663 LHLAVQRSTFLSVINLL------EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 319 DINPLDKERRSPLLLA 334
            ++  D    +PL LA
Sbjct: 717 QLDVQDGVSCTPLQLA 732



 Score = 82.6 bits (195), Expect = 8e-15
 Identities = 71/293 (24%), Positives = 122/293 (41%), Gaps = 16/293 (5%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A   N ++  RL +S  +   + +  G+T  H A+   + +++  + +   +L+A+    
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            TPLH+AVE   + AI++LL+       L++    P+H A    K  + ++  +Y +  +
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA--S 585

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           +      G T LH AA   H L    L+ +  A         + P+H AA++     +  
Sbjct: 586 LELPTHQGWTPLHLAAYKGH-LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            LQ G              +  G  PLH AV      +V   L   A +  +     TP 
Sbjct: 645 LLQCGADPNAA--------EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696

Query: 261 HLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
           HLA  +G   I+K++      E  A L   D    TP+  A       I+++L
Sbjct: 697 HLAALKGNTAILKVLV-----EAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 5/161 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PLH+   +G +  +  L+     ++ +  +  +PL  AA+  +    C LL +      
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-DQQPDLCALLLAHGAD-- 420

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
            N  D +G  PLH A++ G      LLL+ GA +  ++  G  PLHLAA + +     LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            S  +   +  + +G T LH+A      S + LL S G  L
Sbjct: 481 VSRQADP-NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 3/123 (2%)

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           +TPLH    +G    V LLL     +  +  +G  PL +AA         LL + H    
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADA 421

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSAIDYAIYYKFPEAALAMV 587
           +++D+DG   LH A       +  LLL  G C  +      + +  A    F   A  +V
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 588 THE 590
           + +
Sbjct: 482 SRQ 484


>AP001743-1|BAA95526.1|  832|Homo sapiens ANKRD3 protein.
          Length = 832

 Score =  124 bits (298), Expect = 2e-27
 Identities = 98/354 (27%), Positives = 160/354 (45%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 477 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 536

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+       +   + + D  + T +H AA          L+ + + +N +D E R+P+ +
Sbjct: 537 LLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 591

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 592 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 650

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 651 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 705

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G         +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 706 HRGAGK---EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 762

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 763 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 814



 Score = 98.3 bits (234), Expect = 1e-19
 Identities = 83/313 (26%), Positives = 135/313 (43%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 518 RGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 577

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ + + P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 578 VNEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 635

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 636 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 687

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 688 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV-----EEKA 742

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 743 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 801

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 802 LLRHGAHINLQSL 814



 Score = 95.9 bits (228), Expect = 8e-19
 Identities = 77/292 (26%), Positives = 131/292 (44%), Gaps = 16/292 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           + L L+    +  +D    TA H A+   + +    +      +N  D  G TP+HVA +
Sbjct: 535 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQ 594

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGR 149
           +   + +  LL++ V+ S+  +    P+H A     + ++++ AK   + +VN     GR
Sbjct: 595 HGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV-SVNAQTLDGR 653

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T LH AA   H   A+ILI DL ++          P+H AA+   + T  + L     RG
Sbjct: 654 TPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL----HRG 708

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             +E M S    +G   LH A   G +  V+L +   A +  +     T +HLA A G  
Sbjct: 709 AGKEAMTS----DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 764

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           ++V+ + +         +   D Q ++ +H AA   H + V  L+  G+ IN
Sbjct: 765 EVVEELVSAD------VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 810



 Score = 89.8 bits (213), Expect = 5e-17
 Identities = 96/384 (25%), Positives = 154/384 (40%), Gaps = 29/384 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 447 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 500

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            AK+  L N N       G T LH A         ++L+    +   K   + +  +H A
Sbjct: 501 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD-EDQWTALHFA 559

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  +
Sbjct: 560 AQNGDESSTRLLLE--------KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 611

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  +
Sbjct: 612 SLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 667

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
              LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL   
Sbjct: 668 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 727

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L 
Sbjct: 728 N-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDLF 779

Query: 430 NNNNESPLHFAARYGRFHTACQLL 453
           +    S LH AA+     T   LL
Sbjct: 780 DEQGLSALHLAAQGRHAQTVETLL 803



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 479 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 535

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
            LLL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 536 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGRTPMHVACQ 594

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 595 HGQENIVRILLRRGVDVSLQGKD 617


>AF305081-1|AAG25674.1| 1265|Homo sapiens tankyrase-related protein
           protein.
          Length = 1265

 Score =  121 bits (292), Expect = 1e-26
 Identities = 146/590 (24%), Positives = 247/590 (41%), Gaps = 58/590 (9%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A  +G+V+   RL   E        GR  T  H A+     +++ ++     ++ A+D+
Sbjct: 130 EACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAXFGRKDVVEYLLQNGANVQARDD 189

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
            G  PLH A      + +  LL+   + +  +     P+H A    K+ V  V  ++ + 
Sbjct: 190 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 249

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
             +      GRTAL  A     D  AK ++T    E+KK        + E+A++ +   +
Sbjct: 250 PTIRN--TDGRTALDLA-----DPSAKAVLT---GEYKKD------ELLESARSGNEEKM 293

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              L       C         D   + PLH A     +K V+L L+ GA +  +      
Sbjct: 294 MALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 346

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ G
Sbjct: 347 PLHNACSYGHYEVTELLV------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 400

Query: 318 SDINPLDKERRSPLLLAAS-----RAGWRTVHTLIRLGA-DIQLKDINSRNVLHLVVMNG 371
           +D   L+   +S + LA +     R  +     L+   A +  +  I     L +V+   
Sbjct: 401 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFQRPLVAAXAREADVTRIKKHLSLEMVI-QA 459

Query: 372 GRLEDFAASC---------KDHCEKSLLQ--LLNEKDNTGCSPLHYASREGHIRSLENLI 420
            +  + A  C         K  CE  L +   +NEK     +PLH AS + H   +E ++
Sbjct: 460 SQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 519

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           +  A +N  +N  ++ LH AA  G   T   LL       II+    +G T L + +   
Sbjct: 520 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL---QGFTALQMGNEN- 575

Query: 481 HTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
               V  LL  G  L      R  L  AA +G  +T++ L +V S     I+   +T LH
Sbjct: 576 ----VQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 630

Query: 541 LATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
            A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 631 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 680



 Score =  118 bits (284), Expect = 1e-25
 Identities = 124/499 (24%), Positives = 224/499 (44%), Gaps = 52/499 (10%)

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           E LL++    +   ++   P+H+A+E     V++V  K+++   VN     G+T+LH AA
Sbjct: 483 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA--KVNALDNLGQTSLHRAA 540

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHE-AAKNASSRTIEVFLQWGEQRGCTREQM 215
              H    ++L++         C+     +    A    +  ++  LQ G          
Sbjct: 541 YCGHLQTCRLLLS-------YGCDPNIISLQGFTALQMGNENVQQLLQEG---------- 583

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
           ISL ++E +  L  A   GD++ V+ LC          +   STP+H A     + +V+ 
Sbjct: 584 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 643

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +      +  A + + D   + P+H A  + H E+   L+  G+ +N  D  + +PL  A
Sbjct: 644 LL-----QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 698

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA---ASCKDHCEKSLL- 390
           A++  +     L++ GAD   K+ +    L LV      ++D     A+  D  +K  L 
Sbjct: 699 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLA 758

Query: 391 --QLLNEKDNTGC--------SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             + L+  DN  C        +PLH A+   ++   E L++ GA +N ++     PLH A
Sbjct: 759 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 818

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
           A YG    A  L+   K    +N +D    TPLH A+++G T++  LLL  GA    ++ 
Sbjct: 819 ASYGHVDVAALLI---KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 875

Query: 500 NGRNPLHLAAMSGYTKTI------ELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIA 552
            G+ PL L +    +  +        L S +   +L+ +   G T+  L++  + PSS++
Sbjct: 876 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 935

Query: 553 LLLSMGCRLSYNNMDMSAI 571
              S+   LS +  ++S++
Sbjct: 936 AASSLD-NLSGSFSELSSV 953



 Score =  107 bits (256), Expect = 3e-22
 Identities = 129/522 (24%), Positives = 214/522 (40%), Gaps = 55/522 (10%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           +++A SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 282 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 341

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
                PLH A      +  E L++     + ++     P+H A   N+V V  +   Y +
Sbjct: 342 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 401

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      H ++A+  A           L   L  E+++P       +   A+ A    
Sbjct: 402 --DPTLLNCHNKSAIDLAPTPQ-------LKERLAYEFQRPL------VAAXAREADVTR 446

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELC---LRSGAKISTQQH 254
           I+  L           +M+          LH A      K  ++C   LR GA I+ +  
Sbjct: 447 IKKHLSL---------EMVIQASQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 497

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           +  TP+H+A  +   D+V+++   + K     + + D    T +H AA   H +    L+
Sbjct: 498 EFLTPLHVASEKAHNDVVEVVVKHEAK-----VNALDNLGQTSLHRAAYCGHLQTCRLLL 552

Query: 315 NEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
           + G D N +  +        A + G   V  L++ G  I L +  +   L L     G +
Sbjct: 553 SYGCDPNIISLQG-----FTALQMGNENVQQLLQEG--ISLGNSEADRQL-LEAAKAGDV 604

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKNNN 432
           E     C        +Q +N +D  G   +PLH+A+    +  +E L++ GA ++ K+  
Sbjct: 605 ETVKKLC-------TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 657

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
              PLH A  YG +  A  L+   K   ++N +D    TPLH A+ +G   +  LLL  G
Sbjct: 658 GLVPLHNACSYGHYEVAELLV---KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 714

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 715 ADPTKKNRDGNTPLDL-VKDGDTDIQDLLRG-DAALLDAAKK 754



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 25/283 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHD--LSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L  A   GD++ V+  L +  K++++      STP+H A   G  D+V+ +      +  
Sbjct: 128 LFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAXFGRKDVVEYLL-----QNG 181

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + + D   + P+H A  F H E+VN L+  G+D N  D    +PL  AA +       
Sbjct: 182 ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCI 241

Query: 345 TLIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL---- 393
            L++ GA+  +++ + R  L L       V+ G  + ++   S +   E+ ++ LL    
Sbjct: 242 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 301

Query: 394 ---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D    +PLH A+    ++ ++ L++ GA ++ K+  +  PLH A  YG +    
Sbjct: 302 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 361

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            L+   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 362 LLV---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 401



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 91/384 (23%), Positives = 158/384 (41%), Gaps = 36/384 (9%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++  TK  L+    A+E  + +D + + +   +++   D  G+T+ H+A+   +     
Sbjct: 491 NINEKTKEFLTPLHVASEKAH-NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 549

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
            + +Y  D N     G T L +  EN     ++ LLQ+ +  S+ N +    +  A +  
Sbjct: 550 LLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGI--SLGNSEADRQLLEAAKAG 602

Query: 125 KVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYY 184
            V  ++     +S+ N         T LHFAA ++     + L+    A+       G  
Sbjct: 603 DVETVKKLCTVQSV-NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLV 660

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H A         E+ ++ G         ++++ D     PLH A   G  +  +L L+
Sbjct: 661 PLHNACSYGHYEVAELLVKHG--------AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 712

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLM---FTMQPKEKHACL-----------TSC 290
            GA  + +  D +TP+ L    G  DI  L+     +    K  CL            +C
Sbjct: 713 HGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 771

Query: 291 -DVQ--KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
            D Q    TP+H AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI
Sbjct: 772 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 831

Query: 348 RLGADIQLKDINSRNVLHLVVMNG 371
           +  A +   D  +   LH     G
Sbjct: 832 KYNACVNATDKWAFTPLHEAAQKG 855



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 8/136 (5%)

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           ++ G   TPLH A+  G   VV  LL  GA +  RD  G  PLH A   G+ + + LL  
Sbjct: 153 DTAGRKSTPLHFAAXFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR 212

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPE 581
            H    +  D    T LH A ++ K     +LL  G   +  N D  +A+D A       
Sbjct: 213 -HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DP 266

Query: 582 AALAMVTHEQRAKEVM 597
           +A A++T E +  E++
Sbjct: 267 SAKAVLTGEYKKDELL 282



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 30/128 (23%), Positives = 57/128 (44%), Gaps = 4/128 (3%)

Query: 34  LSEPSRLAVRDGRGR--TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           LS P  +  RD +GR  T  H A+  NN  +  ++  +  D+NA+D  G  PLH A    
Sbjct: 763 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 822

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTA 151
            +D    L++ +   +  ++    P+H A +  +  +  +   + +  +     + G+T 
Sbjct: 823 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA--DPTLKNQEGQTP 880

Query: 152 LHFAAIHD 159
           L   +  D
Sbjct: 881 LDLVSADD 888


>AK027424-1|BAB55102.1|  784|Homo sapiens protein ( Homo sapiens
           cDNA FLJ14518 fis, clone NT2RM1000850, weakly similar to
           ANKYRIN R. ).
          Length = 784

 Score =  119 bits (287), Expect = 5e-26
 Identities = 96/354 (27%), Positives = 159/354 (44%), Gaps = 17/354 (4%)

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           Q + L  + G   LH AV  G  +  +  L + A  +      STP+H+A  +    +V+
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
            +       +   + + D  + T +H AA          L+ + + +N +D E  +P+ +
Sbjct: 489 RLLA-----RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGLTPMHV 543

Query: 334 AASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLL 393
           A        V  L+R G D+ L+  ++   LH     G  L       K        Q L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTL 602

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           +     G +PLH A++ GH R    LI L + +N+ +   ++PLH AA  G   TA  LL
Sbjct: 603 D-----GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSG 512
               G   +     +G T LH+A+R GH   V LL+   A +L R    +  LHLAA  G
Sbjct: 658 HRGAGKEAVT---SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           +++ +E L  V + ++D  D+ G ++LHLA       ++  LL  G  ++  ++
Sbjct: 715 HSEVVEEL--VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 83/313 (26%), Positives = 134/313 (42%), Gaps = 16/313 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG T  H A  R    ++  +      +NAKD    T LH A +N    +   LL+++  
Sbjct: 470 RGSTPLHMAVERRVRGVVERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + ++ +   P+H+A +  + +++++  +     +V+  G+     LH+AA   H    K
Sbjct: 530 VNEVDFEGLTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVK 587

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L             +G  P+H AA+    R   + +       C+   + SL       
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL-----CSDVNVCSLL---AQT 639

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A   G      L L  GA       D  T +HLA   G L  VKL+      E+ A
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV-----EEKA 694

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + +      T +H AA   H E+V  L++    I+  D++  S L LAA     +TV T
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVET 753

Query: 346 LIRLGADIQLKDI 358
           L+R GA I L+ +
Sbjct: 754 LLRHGAHINLQSL 766



 Score = 89.4 bits (212), Expect = 7e-17
 Identities = 96/385 (24%), Positives = 154/385 (40%), Gaps = 31/385 (8%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           DL   D      +   V  +    ++ L  Q V+ ++  +   + +H+A E  +    + 
Sbjct: 399 DLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLAL--DSGASLLHLAVEAGQ----EE 452

Query: 132 FAKYKSLFNVNQG--GEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHE 188
            AK+  L N N       G T LH A       +  ++L   +    K    + +  +H 
Sbjct: 453 CAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVERLLARKISVNAKD--EDQWTALHF 510

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA+N    +  + L+        +   ++  D EG  P+H A   G    V + LR G  
Sbjct: 511 AAQNGDESSTRLLLE--------KNASVNEVDFEGLTPMHVACQHGQENIVRILLRRGVD 562

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           +S Q  D   P+H A  QG L IVKL+     K+    + +  +   TP+H AA   H  
Sbjct: 563 VSLQGKDAWLPLHYAAWQGHLPIVKLL----AKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +   LI+  SD+N      ++PL +AA      T   L+  GA  +    +    LHL  
Sbjct: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAA 678

Query: 369 MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
            N G L       ++  +      LN+      + LH A+  GH   +E L+     I+L
Sbjct: 679 RN-GHLATVKLLVEEKADVLARGPLNQ------TALHLAAAHGHSEVVEELVSADV-IDL 730

Query: 429 KNNNNESPLHFAARYGRFHTACQLL 453
            +    S LH AA+     T   LL
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLL 755



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 64/258 (24%), Positives = 108/258 (41%), Gaps = 29/258 (11%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA++G+ +   RL L + + +   D  G T  H A      NI+  +     D++ +   
Sbjct: 511 AAQNGD-ESSTRLLLEKNASVNEVDFEGLTPMHVACQHGQENIVRILLRRGVDVSLQGKD 569

Query: 80  GNTPLHVAVENEALDAIEYLLQQ-HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
              PLH A     L  ++ L +Q  V  +      + P+H+A +     V ++     S 
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS- 628

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
            +VN      +T LH AA   H   A++L+    A  +   ++GY  +H AA+N    T+
Sbjct: 629 -DVNVCSLLAQTPLHVAAETGHTSTARLLL-HRGAGKEAVTSDGYTALHLAARNGHLATV 686

Query: 199 EVFLQWGEQ---RGCTR----------------EQMIS-----LYDNEGNVPLHSAVHGG 234
           ++ ++       RG                   E+++S     L+D +G   LH A  G 
Sbjct: 687 KLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGR 746

Query: 235 DIKAVELCLRSGAKISTQ 252
             + VE  LR GA I+ Q
Sbjct: 747 HAQTVETLLRHGAHINLQ 764



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 40/143 (27%), Positives = 69/143 (48%), Gaps = 5/143 (3%)

Query: 426 INLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVV 485
           ++L  ++  S LH A   G+   A  LL ++      N S+  G TPLH+A       VV
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANP---NLSNRRGSTPLHMAVERRVRGVV 487

Query: 486 HLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
             LL R   ++ +D +    LH AA +G   +  LL   ++ + +++D +G T +H+A  
Sbjct: 488 ERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV-NEVDFEGLTPMHVACQ 546

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
             + + + +LL  G  +S    D
Sbjct: 547 HGQENIVRILLRRGVDVSLQGKD 569


>BC098394-1|AAH98394.1| 1327|Homo sapiens tankyrase,
           TRF1-interacting ankyrin-related ADP-ribose polymerase
           protein.
          Length = 1327

 Score =  119 bits (286), Expect = 7e-26
 Identities = 134/524 (25%), Positives = 223/524 (42%), Gaps = 58/524 (11%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 340 LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 399

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G  PLH A      +  E LL+     + ++     P+H A   N+V V  +   + +
Sbjct: 400 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      HG++A+  A   +       L   L  E+K       + + +AA+ A    
Sbjct: 460 --DPTLVNCHGKSAVDMAPTPE-------LRERLTYEFKG------HSLLQAAREADLAK 504

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGN-VPLHSAV---HGGDIKAVELCLRSGAKISTQQ 253
           ++  L           ++I+    + +   LH AV   H    +  EL LR GA ++ + 
Sbjct: 505 VKKTLAL---------EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            D  TP+H+A  +   D+++++       KH A + + D    T +H AA+  H +    
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVL------HKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ GSD + +  +        A++ G   V  ++     I+  D++ R    L     G
Sbjct: 610 LLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR---LLEASKAG 661

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKN 430
            LE     C         Q +N +D  G   +PLH+A+    +  +E L+  GA ++ K+
Sbjct: 662 DLETVKQLCSS-------QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD 714

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
                PLH A  YG +  A +LL     +  +N +D    TPLH A+ +G   +  LLL 
Sbjct: 715 KGGLVPLHNACSYGHYEVA-ELLVRHGAS--VNVADLWKFTPLHEAAAKGKYEICKLLLK 771

Query: 491 RGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
            GA    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 772 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRG-DAALLDAAKK 813



 Score =  105 bits (251), Expect = 1e-21
 Identities = 136/591 (23%), Positives = 249/591 (42%), Gaps = 57/591 (9%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++A  +G+V    RL  +         GR  +  H A+     +++  +     +++A+D
Sbjct: 187 LEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           + G  PLH A      + +  LL Q  + +  +     P+H A    K+ V  V  ++ +
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             N+      G++AL  A     D  AK ++T    E+KK        + EAA++ +   
Sbjct: 307 DPNIR--NTDGKSALDLA-----DPSAKAVLT---GEYKKD------ELLEAARSGNEEK 350

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           +   L       C         D   + PLH A     ++ V+L L+ GA +  +     
Sbjct: 351 LMALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
            P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ 
Sbjct: 404 VPLHNACSYGHYEVTELLL------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457

Query: 317 GSDINPLDKERRSPLLLAAS-----RAGWR-TVHTLIRLGADIQLKDINSRNVLHLVVMN 370
           G+D   ++   +S + +A +     R  +    H+L++   +  L  +     L ++   
Sbjct: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK 517

Query: 371 GGRLEDFAASCK----DHCEKSLLQLL-------NEKDNTGCSPLHYASREGHIRSLENL 419
             +  + A  C         K + +LL       NEK+    +PLH A+   H   +E L
Sbjct: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
            + GA +N  +   ++ LH AA  G   T   LL       II+    +G T    A++ 
Sbjct: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL---QGFT----AAQM 630

Query: 480 GHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           G+  V  +L     +   D + R  L  A+ +G  +T++ L S  +     ++   +T L
Sbjct: 631 GNEAVQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPL 688

Query: 540 HLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
           H A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 689 HFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 145/581 (24%), Positives = 232/581 (39%), Gaps = 82/581 (14%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           ++L L   + +  +D  G    H A +  +  +   +  +   +NA D    TPLH A  
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMAT----------ELNKVSVLQV-----FAK 134
              ++    LL    + +++N   ++ + MA           E    S+LQ       AK
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 504

Query: 135 YKS-----LFNVNQGGEHGRTALHFAAIHDHDLCAKI--LITDLDAEWKKPCNNGYYPIH 187
            K      + N  Q   H  TALH A    H    ++  L+    A   +   +   P+H
Sbjct: 505 VKKTLALEIINFKQPQSH-ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLH 563

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA+ A +  +EV  + G +        ++  D  G   LH A   G ++   L L  G+
Sbjct: 564 VAAERAHNDVMEVLHKHGAK--------MNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615

Query: 248 K---ISTQ------------QHDLS--TPVHL---------ACAQGALDIVKLMFTMQPK 281
               IS Q            Q  LS  TP+           A   G L+ VK + + Q  
Sbjct: 616 DPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-- 673

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
             +      + +  TP+H AA ++   +V YL++ G+D++  DK    PL  A S   + 
Sbjct: 674 --NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 731

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGG------RLEDFAASCKDHCE-KSLLQLLN 394
               L+R GA + + D+     LH     G        L+  A   K + +  + L L+ 
Sbjct: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 791

Query: 395 EKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
           E D        G + L  A+++G +  ++ L      IN ++    N +PLH AA Y   
Sbjct: 792 EGDTDIQDLLRGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNL 850

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPL 505
             A  LL+       +N  D  GL PLH A+  GH  +  LL+     ++  D     PL
Sbjct: 851 EVAEYLLEHGAD---VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMEN 546
           H AA  G T+   LL   H       +++G T L LAT ++
Sbjct: 908 HEAAQKGRTQLCALL-LAHGADPTMKNQEGQTPLDLATADD 947



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 76/282 (26%), Positives = 127/282 (45%), Gaps = 23/282 (8%)

Query: 227 LHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           L  A   GD+  V+ L   +           S+P+H A   G  D+V+ +  M      A
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG-----A 240

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + + D   + P+H A  F H E+V+ L+ +G+D N  D    +PL  AA +        
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300

Query: 346 LIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL----- 393
           L++ GAD  +++ + ++ L L       V+ G  + ++   + +   E+ L+ LL     
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360

Query: 394 --NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
             +  D    +PLH A+    +R ++ L++ GA ++ K+     PLH A  YG +     
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LL   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 421 LL---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 82/337 (24%), Positives = 147/337 (43%), Gaps = 36/337 (10%)

Query: 6   LSTSTKVNLSF----FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTN 61
           LS ST +  S      ++A+++G+++   +L  S+       +GR  T  H A+  N  +
Sbjct: 639 LSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVS 698

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           ++ ++ ++  D++AKD  G  PLH A      +  E L++     +V +     P+H A 
Sbjct: 699 VVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAA 758

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
              K  + ++  K+ +  +  +    G T L      D D      I DL          
Sbjct: 759 AKGKYEICKLLLKHGA--DPTKKNRDGNTPLDLVKEGDTD------IQDL--------LR 802

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG--NVPLHSAVHGGDIKAV 239
           G   + +AAK      +        Q+ CT E  I+  D +G  + PLH A    +++  
Sbjct: 803 GDAALLDAAKKGCLARV--------QKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVA 853

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E  L  GA ++ Q      P+H A + G +DI  L+      + + C+ + D    TP+H
Sbjct: 854 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI-----KYNTCVNATDKWAFTPLH 908

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
            AA     ++   L+  G+D    ++E ++PL LA +
Sbjct: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 92/371 (24%), Positives = 148/371 (39%), Gaps = 40/371 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AAE  + +D M +     +++   D  G+TA H+A+   +      + +Y  D +     
Sbjct: 565 AAERAH-NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ 623

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T   +   NEA+  I       + TS ++       +   E +K   L+   +  S  
Sbjct: 624 GFTAAQMG--NEAVQQI-LSESTPIRTSDVD-------YRLLEASKAGDLETVKQLCSSQ 673

Query: 140 NVNQGGEHGR--TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           NVN     GR  T LHFAA ++     + L+    A+       G  P+H A        
Sbjct: 674 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEV 732

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ ++ G          +++ D     PLH A   G  +  +L L+ GA  + +  D +
Sbjct: 733 AELLVRHGAS--------VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 784

Query: 258 TPVHLACAQGALDIVKLM---FTMQPKEKHACLT-----------SC-DVQ--KMTPIHC 300
           TP+ L   +G  DI  L+     +    K  CL            +C D Q    TP+H 
Sbjct: 785 TPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 843

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI+    +   D  +
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903

Query: 361 RNVLHLVVMNG 371
              LH     G
Sbjct: 904 FTPLHEAAQKG 914


>BC024725-1|AAH24725.1|  743|Homo sapiens ANKRD50 protein protein.
          Length = 743

 Score =  119 bits (286), Expect = 7e-26
 Identities = 121/440 (27%), Positives = 187/440 (42%), Gaps = 54/440 (12%)

Query: 141 VNQGGEHGRTALHFAAI-----HDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           VN     GRTAL  AA+       H     +LI D  AE      +G  P+  AA     
Sbjct: 17  VNHEDVDGRTALSVAALCVPASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHV 75

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
             +++ L+ G     T        DN G  PL +A   G    V   L  GA + +   +
Sbjct: 76  DVVDLLLEGGADVDHT--------DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 127

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + +A AQG +++V+ +      E H      D    TP+H AA   H  I   LI 
Sbjct: 128 GRTVLSIASAQGNVEVVRTLLDRGLDENHR-----DDAGWTPLHMAAFEGHRLICEALIE 182

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR-- 373
           +G+  N +D + R P +LA+    +  V  L+   ++I  +  + RN L +  + G R  
Sbjct: 183 QGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 242

Query: 374 ---LEDFAA--SCKDHCEKSLLQLL-------------------NEKDNTGCSPLHYASR 409
              L    A  +CKD   +  L +L                      D  G + LH +  
Sbjct: 243 VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 302

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           +GH+  ++ LI   A +N  +N   S L  AA  G       L++      +++ +  +G
Sbjct: 303 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA---VVDHTCNQG 359

Query: 470 LTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
            T L IA++EGH  VV +LL  GA   H D  GR  + +AA +G+++ I+LL    +  L
Sbjct: 360 ATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 419

Query: 529 DQIDKDGNTSLHLATMENKP 548
                +G +   + TME KP
Sbjct: 420 -----NGCSPSPVHTMEQKP 434



 Score =  117 bits (282), Expect = 2e-25
 Identities = 95/363 (26%), Positives = 170/363 (46%), Gaps = 23/363 (6%)

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLAC-----AQGALDIVKLMFTMQPKEKHACLT 288
           G  + VE  L  GA+++ +  D  T + +A      ++G   +V L+     +  H    
Sbjct: 2   GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH---- 57

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
            CD   MTP+  AA   H ++V+ L+  G+D++  D   R+PLL AAS      V+TL+ 
Sbjct: 58  -CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF 116

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GA +   D   R VL +    G          +   ++ L +  N +D+ G +PLH A+
Sbjct: 117 WGAAVDSIDSEGRTVLSIASAQGN-----VEVVRTLLDRGLDE--NHRDDAGWTPLHMAA 169

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
            EGH    E LI  GA  N  +N+   P   A++ G +     LL++      I++   +
Sbjct: 170 FEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN---IDQRGYD 226

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
           G   L +A+ EGH  +V LL + GA ++ +D +GR  L++ A+       E      ++ 
Sbjct: 227 GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGAN- 285

Query: 528 LDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
           ++  D +G T+LH++  +     + +L++    + + +N   SA+  A +    +    +
Sbjct: 286 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 345

Query: 587 VTH 589
           + H
Sbjct: 346 IEH 348



 Score =  101 bits (243), Expect = 1e-20
 Identities = 93/345 (26%), Positives = 155/345 (44%), Gaps = 27/345 (7%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +G  PL  A + G +  V+L L  GA +    ++  TP+  A + G   +V  +    
Sbjct: 59  DKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW- 117

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
                A + S D +  T +  A+   + E+V  L++ G D N  D    +PL +AA    
Sbjct: 118 ----GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 173

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDH--CEKSLLQ---LLN 394
                 LI  GA  +  +I+          N GR+    AS + H  C + LL+    ++
Sbjct: 174 RLICEALIEQGA--RTNEID----------NDGRIPFILASQEGHYDCVQILLENKSNID 221

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
           ++   G + L  A+ EGH   +E L   GA +N K+ +    L+  A   +   A   L+
Sbjct: 222 QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE 281

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGY 513
           +      +  SD EG T LH++  +GH  +V +L+   A ++  D+  R+ L  AA  G+
Sbjct: 282 NGAN---VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 338

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            K ++LL   H  ++D     G T+L +A  E     + +LL  G
Sbjct: 339 VKVVQLLIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 382



 Score = 93.9 bits (223), Expect = 3e-18
 Identities = 78/309 (25%), Positives = 136/309 (44%), Gaps = 18/309 (5%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D  GRT    ASA+ N  ++  + +   D N +D+AG TPLH+A         E L++Q 
Sbjct: 125 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 184

Query: 104 VETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DL 162
             T+ ++   + P  +A++      +Q+  + KS  N++Q G  GR AL  AA+  H D+
Sbjct: 185 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKS--NIDQRGYDGRNALRVAALEGHRDI 242

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE 222
              +     D   K    +G   ++  A        E FL+ G          +   D E
Sbjct: 243 VELLFSHGADVNCKDA--DGRPTLYILALENQLTMAEYFLENGAN--------VEASDAE 292

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G   LH +   G ++ V++ +   A ++   ++  + +  A  QG + +V+L+       
Sbjct: 293 GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 352

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
            H C      Q  T +  AA   H ++V  L+  G+D N  D+  R+ + +AA     + 
Sbjct: 353 DHTC-----NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 407

Query: 343 VHTLIRLGA 351
           +  L + GA
Sbjct: 408 IKLLEKYGA 416



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 90/408 (22%), Positives = 170/408 (41%), Gaps = 32/408 (7%)

Query: 44  DGRGRTAAHQAS-----ARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEY 98
           D  GRTA   A+     ++ + +++  + +   +++  D  G TPL VA     +D ++ 
Sbjct: 21  DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 80

Query: 99  LLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIH 158
           LL+   +    +   + P+  A  +   SV+     + +   V+     GRT L  A+  
Sbjct: 81  LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA--VDSIDSEGRTVLSIASAQ 138

Query: 159 DH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMIS 217
            + ++   +L   LD   +     G+ P+H AA        E  ++ G +   T E    
Sbjct: 139 GNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGAR---TNE---- 189

Query: 218 LYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
             DN+G +P   A   G    V++ L + + I  + +D    + +A  +G  DIV+L+F+
Sbjct: 190 -IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 248

Query: 278 MQPKEKHACLTSC-DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
                 H    +C D      ++  A+ +   +  Y +  G+++   D E R+ L ++  
Sbjct: 249 ------HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 302

Query: 337 RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEK 396
           +     V  LI   AD+   D   R+ L      G           +H       +++  
Sbjct: 303 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH--VKVVQLLIEHGA-----VVDHT 355

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
            N G + L  A++EGHI  ++ L+  GA  N  +    + +  AA+ G
Sbjct: 356 CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNG 403



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 80/382 (20%), Positives = 159/382 (41%), Gaps = 22/382 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+VD  + L L   + +   D  GRT    A++  + ++++ +  +   +++ D+ 
Sbjct: 69  AAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 127

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T L +A     ++ +  LL + ++ +  ++    P+HMA       + +   +  +  
Sbjct: 128 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA-- 185

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             N+    GR     A+   H  C +IL+ +  +   +   +G   +  AA       +E
Sbjct: 186 RTNEIDNDGRIPFILASQEGHYDCVQILLEN-KSNIDQRGYDGRNALRVAALEGHRDIVE 244

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           +    G    C         D +G   L+       +   E  L +GA +     +  T 
Sbjct: 245 LLFSHGADVNCK--------DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 296

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H++C QG +++V+++        HA + + D +K + +  AA   H ++V  LI  G+ 
Sbjct: 297 LHVSCWQGHMEMVQVLIAY-----HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 351

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR-----L 374
           ++    +  + L +AA       V  L+  GAD    D   R  + +   NG       L
Sbjct: 352 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 411

Query: 375 EDFAASCKDHCEKSLLQLLNEK 396
           E + AS  + C  S +  + +K
Sbjct: 412 EKYGASSLNGCSPSPVHTMEQK 433



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 48/190 (25%), Positives = 89/190 (46%), Gaps = 6/190 (3%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A++ G+ D  +++ L   S +  R   GR A   A+   + +I+  + ++  D+N K
Sbjct: 198 FILASQEGHYD-CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 256

Query: 77  DNAGNTPLHV-AVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY 135
           D  G   L++ A+EN+ L   EY L+        + + +  +H++     + ++QV   Y
Sbjct: 257 DADGRPTLYILALENQ-LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 315

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  +VN      R+AL  AA   H    ++LI +  A     CN G   +  AA+    
Sbjct: 316 HA--DVNAADNEKRSALQSAAWQGHVKVVQLLI-EHGAVVDHTCNQGATALCIAAQEGHI 372

Query: 196 RTIEVFLQWG 205
             ++V L+ G
Sbjct: 373 DVVQVLLEHG 382


>AB209339-1|BAD92576.1| 1055|Homo sapiens tankyrase,
           TRF1-interacting ankyrin-related ADP-ribose polymerase
           variant protein.
          Length = 1055

 Score =  119 bits (286), Expect = 7e-26
 Identities = 134/524 (25%), Positives = 223/524 (42%), Gaps = 58/524 (11%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 68  LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 127

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G  PLH A      +  E LL+     + ++     P+H A   N+V V  +   + +
Sbjct: 128 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 187

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      HG++A+  A   +       L   L  E+K       + + +AA+ A    
Sbjct: 188 --DPTLVNCHGKSAVDMAPTPE-------LRERLTYEFKG------HSLLQAAREADLAK 232

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGN-VPLHSAV---HGGDIKAVELCLRSGAKISTQQ 253
           ++  L           ++I+    + +   LH AV   H    +  EL LR GA ++ + 
Sbjct: 233 VKKTLAL---------EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 283

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            D  TP+H+A  +   D+++++       KH A + + D    T +H AA+  H +    
Sbjct: 284 KDFMTPLHVAAERAHNDVMEVL------HKHGAKMNALDTLGQTALHRAALAGHLQTCRL 337

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ GSD + +  +        A++ G   V  ++     I+  D++ R    L     G
Sbjct: 338 LLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR---LLEASKAG 389

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKN 430
            LE     C         Q +N +D  G   +PLH+A+    +  +E L+  GA ++ K+
Sbjct: 390 DLETVKQLCSS-------QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD 442

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
                PLH A  YG +  A +LL     +  +N +D    TPLH A+ +G   +  LLL 
Sbjct: 443 KGGLVPLHNACSYGHYEVA-ELLVRHGAS--VNVADLWKFTPLHEAAAKGKYEICKLLLK 499

Query: 491 RGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
            GA    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 500 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRG-DAALLDAAKK 541



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 145/581 (24%), Positives = 232/581 (39%), Gaps = 82/581 (14%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           ++L L   + +  +D  G    H A +  +  +   +  +   +NA D    TPLH A  
Sbjct: 113 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 172

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMAT----------ELNKVSVLQV-----FAK 134
              ++    LL    + +++N   ++ + MA           E    S+LQ       AK
Sbjct: 173 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 232

Query: 135 YKS-----LFNVNQGGEHGRTALHFAAIHDHDLCAKI--LITDLDAEWKKPCNNGYYPIH 187
            K      + N  Q   H  TALH A    H    ++  L+    A   +   +   P+H
Sbjct: 233 VKKTLALEIINFKQPQSH-ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLH 291

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA+ A +  +EV  + G +        ++  D  G   LH A   G ++   L L  G+
Sbjct: 292 VAAERAHNDVMEVLHKHGAK--------MNALDTLGQTALHRAALAGHLQTCRLLLSYGS 343

Query: 248 K---ISTQ------------QHDLS--TPVHL---------ACAQGALDIVKLMFTMQPK 281
               IS Q            Q  LS  TP+           A   G L+ VK + + Q  
Sbjct: 344 DPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-- 401

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
             +      + +  TP+H AA ++   +V YL++ G+D++  DK    PL  A S   + 
Sbjct: 402 --NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 459

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGG------RLEDFAASCKDHCE-KSLLQLLN 394
               L+R GA + + D+     LH     G        L+  A   K + +  + L L+ 
Sbjct: 460 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 519

Query: 395 EKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
           E D        G + L  A+++G +  ++ L      IN ++    N +PLH AA Y   
Sbjct: 520 EGDTDIQDLLRGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNL 578

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPL 505
             A  LL+       +N  D  GL PLH A+  GH  +  LL+     ++  D     PL
Sbjct: 579 EVAEYLLEHGAD---VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 635

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMEN 546
           H AA  G T+   LL   H       +++G T L LAT ++
Sbjct: 636 HEAAQKGRTQLCALL-LAHGADPTMKNQEGQTPLDLATADD 675



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 82/337 (24%), Positives = 147/337 (43%), Gaps = 36/337 (10%)

Query: 6   LSTSTKVNLSF----FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTN 61
           LS ST +  S      ++A+++G+++   +L  S+       +GR  T  H A+  N  +
Sbjct: 367 LSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVS 426

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           ++ ++ ++  D++AKD  G  PLH A      +  E L++     +V +     P+H A 
Sbjct: 427 VVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAA 486

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
              K  + ++  K+ +  +  +    G T L      D D      I DL          
Sbjct: 487 AKGKYEICKLLLKHGA--DPTKKNRDGNTPLDLVKEGDTD------IQDL--------LR 530

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG--NVPLHSAVHGGDIKAV 239
           G   + +AAK      +        Q+ CT E  I+  D +G  + PLH A    +++  
Sbjct: 531 GDAALLDAAKKGCLARV--------QKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVA 581

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E  L  GA ++ Q      P+H A + G +DI  L+      + + C+ + D    TP+H
Sbjct: 582 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI-----KYNTCVNATDKWAFTPLH 636

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
            AA     ++   L+  G+D    ++E ++PL LA +
Sbjct: 637 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 673



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 96/363 (26%), Positives = 154/363 (42%), Gaps = 44/363 (12%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQ---RGCTREQMISLYDNEGNVP---------- 226
           N  Y P+HEAA         V LQ G     R    +  + L D                
Sbjct: 8   NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDEL 67

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L +A  G + K + L               STP+HLA     + IV+L+      +  A 
Sbjct: 68  LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLL-----QHGAD 122

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           + + D   + P+H A  + H E+   L+  G+ +N +D  + +PL  AAS+        L
Sbjct: 123 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 182

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +  GAD  L + + ++ + +      R E      K H   SLLQ               
Sbjct: 183 LSHGADPTLVNCHGKSAVDMAPTPELR-ERLTYEFKGH---SLLQ--------------- 223

Query: 407 ASREGHIRSLENLIRLGACINLKN-NNNESPLH--FAARYGRFHTACQLLDSDKGTFIIN 463
           A+RE  +  ++  + L   IN K   ++E+ LH   A+ + +     +LL   KG   +N
Sbjct: 224 AAREADLAKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELL-LRKGA-NVN 280

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHS 522
           E + + +TPLH+A+   H  V+ +L   GA ++  D  G+  LH AA++G+ +T  LL S
Sbjct: 281 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 340

Query: 523 VHS 525
             S
Sbjct: 341 YGS 343



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 92/371 (24%), Positives = 148/371 (39%), Gaps = 40/371 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AAE  + +D M +     +++   D  G+TA H+A+   +      + +Y  D +     
Sbjct: 293 AAERAH-NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ 351

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T   +   NEA+  I       + TS ++       +   E +K   L+   +  S  
Sbjct: 352 GFTAAQMG--NEAVQQI-LSESTPIRTSDVD-------YRLLEASKAGDLETVKQLCSSQ 401

Query: 140 NVNQGGEHGR--TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           NVN     GR  T LHFAA ++     + L+    A+       G  P+H A        
Sbjct: 402 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEV 460

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ ++ G          +++ D     PLH A   G  +  +L L+ GA  + +  D +
Sbjct: 461 AELLVRHGAS--------VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 512

Query: 258 TPVHLACAQGALDIVKLM---FTMQPKEKHACLT-----------SC-DVQ--KMTPIHC 300
           TP+ L   +G  DI  L+     +    K  CL            +C D Q    TP+H 
Sbjct: 513 TPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 571

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI+    +   D  +
Sbjct: 572 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 631

Query: 361 RNVLHLVVMNG 371
              LH     G
Sbjct: 632 FTPLHEAAQKG 642



 Score = 68.1 bits (159), Expect = 2e-10
 Identities = 62/201 (30%), Positives = 94/201 (46%), Gaps = 21/201 (10%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF-----HT 448
           N +DN   +PLH A+ +G I     L++ GA  N++N + +S L  A    +      + 
Sbjct: 4   NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYK 63

Query: 449 ACQLLDSDKG-------------TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
             +LL++ +                  + SDG   TPLH+A+     R+V LLL  GA +
Sbjct: 64  KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADV 123

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
           H +D  G  PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+    +LL
Sbjct: 124 HAKDKGGLVPLHNACSYGHYEVTELLLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLL 182

Query: 555 LSMGCRLSYNNM-DMSAIDYA 574
           LS G   +  N    SA+D A
Sbjct: 183 LSHGADPTLVNCHGKSAVDMA 203



 Score = 58.4 bits (135), Expect = 1e-07
 Identities = 51/190 (26%), Positives = 86/190 (45%), Gaps = 17/190 (8%)

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV------VMNG 371
           +D N  D    +PL  AA +        L++ GAD  +++ + ++ L L       V+ G
Sbjct: 1   ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG 60

Query: 372 G-RLEDFAASCKDHCEKSLLQLL-------NEKDNTGCSPLHYASREGHIRSLENLIRLG 423
             + ++   + +   E+ L+ LL       +  D    +PLH A+    +R ++ L++ G
Sbjct: 61  EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 120

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTR 483
           A ++ K+     PLH A  YG +     LL   K    +N  D    TPLH A+ +    
Sbjct: 121 ADVHAKDKGGLVPLHNACSYGHYEVTELLL---KHGACVNAMDLWQFTPLHEAASKNRVE 177

Query: 484 VVHLLLNRGA 493
           V  LLL+ GA
Sbjct: 178 VCSLLLSHGA 187



 Score = 55.6 bits (128), Expect = 1e-06
 Identities = 95/361 (26%), Positives = 147/361 (40%), Gaps = 47/361 (13%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           DN    PLH A   G I    + L+ GA  + +  D          + ALD+        
Sbjct: 7   DNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTD---------GKSALDLA------D 51

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
           P  K A LT  + +K   +  A   +  +++  L     + +  D  + +PL LAA    
Sbjct: 52  PSAK-AVLTG-EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR 109

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
            R V  L++ GAD+  KD      LH    + G  E      K          +N  D  
Sbjct: 110 VRIVQLLLQHGADVHAKDKGGLVPLHNAC-SYGHYEVTELLLKHGA------CVNAMDLW 162

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAAR--------YG-RFHTAC 450
             +PLH A+ +  +     L+  GA   L N + +S +  A          Y  + H+  
Sbjct: 163 QFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLL 222

Query: 451 QLL-DSD----KGTF---IINESDGEGL-TPLHIASREGHTR---VVHLLLNRGALLH-R 497
           Q   ++D    K T    IIN    +   T LH A    H +   V  LLL +GA ++ +
Sbjct: 223 QAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEK 282

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           + +   PLH+AA   +   +E+LH  H   ++ +D  G T+LH A +     +  LLLS 
Sbjct: 283 NKDFMTPLHVAAERAHNDVMEVLHK-HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 341

Query: 558 G 558
           G
Sbjct: 342 G 342



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 51/206 (24%), Positives = 83/206 (40%), Gaps = 23/206 (11%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D NA+DN   TPLH A     +D    LLQ   + ++ N   ++ + +A    K  +   
Sbjct: 2   DPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGE 61

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
           + K + L     G E    AL               +T L+            P+H AA 
Sbjct: 62  YKKDELLEAARSGNEEKLMAL---------------LTPLNVNCHASDGRKSTPLHLAAG 106

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
               R +++ LQ G          +   D  G VPLH+A   G  +  EL L+ GA ++ 
Sbjct: 107 YNRVRIVQLLLQHGAD--------VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 158

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFT 277
                 TP+H A ++  +++  L+ +
Sbjct: 159 MDLWQFTPLHEAASKNRVEVCSLLLS 184


>AF082557-1|AAC79842.1| 1094|Homo sapiens TRF1-interacting
           ankyrin-related ADP-ribose polymerase protein.
          Length = 1094

 Score =  118 bits (285), Expect = 9e-26
 Identities = 134/524 (25%), Positives = 223/524 (42%), Gaps = 58/524 (11%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 107 LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 166

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G  PLH A      +  E LL+     + ++     P+H A   N+V V  +   + +
Sbjct: 167 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 226

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      HG++A+  A   +       L   L  E+K       + + +AA+ A    
Sbjct: 227 --DPTLVNCHGKSAVDMAPTPE-------LRERLTYEFKG------HSLLQAAREADLAK 271

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGN-VPLHSAV---HGGDIKAVELCLRSGAKISTQQ 253
           ++  L           ++I+    + +   LH AV   H    +  EL LR GA ++ + 
Sbjct: 272 VKKTLAL---------EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 322

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            D  TP+H+A  +   D+++++       KH A + + D    T +H AA+  H +    
Sbjct: 323 KDFMTPLHVAAERAHNDVMEVL------HKHGAKMNALDTLGQTALHRAALAGHLQTCRL 376

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ GSD + +  +        A++ G   V  ++     I+  D++ R    L     G
Sbjct: 377 LLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR---LLEASKAG 428

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKN 430
            LE     C         Q +N +D  G   +PLH+A+    +  +E L+  GA ++ K+
Sbjct: 429 DLETVKQLCSS-------QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD 481

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
                PLH A  YG +  A +LL     +  +N +D    TPLH A+ +G   +  LLL 
Sbjct: 482 KGGLVPLHNACSYGHYEVA-ELLVRHGAS--VNVADLWKFTPLHEAAAKGKYEICKLLLK 538

Query: 491 RGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
            GA    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 539 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLKG-DAALLDAAKK 580



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 145/581 (24%), Positives = 232/581 (39%), Gaps = 82/581 (14%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           ++L L   + +  +D  G    H A +  +  +   +  +   +NA D    TPLH A  
Sbjct: 152 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 211

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMAT----------ELNKVSVLQV-----FAK 134
              ++    LL    + +++N   ++ + MA           E    S+LQ       AK
Sbjct: 212 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 271

Query: 135 YKS-----LFNVNQGGEHGRTALHFAAIHDHDLCAKI--LITDLDAEWKKPCNNGYYPIH 187
            K      + N  Q   H  TALH A    H    ++  L+    A   +   +   P+H
Sbjct: 272 VKKTLALEIINFKQPQSH-ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLH 330

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA+ A +  +EV  + G +        ++  D  G   LH A   G ++   L L  G+
Sbjct: 331 VAAERAHNDVMEVLHKHGAK--------MNALDTLGQTALHRAALAGHLQTCRLLLSYGS 382

Query: 248 K---ISTQ------------QHDLS--TPVHL---------ACAQGALDIVKLMFTMQPK 281
               IS Q            Q  LS  TP+           A   G L+ VK + + Q  
Sbjct: 383 DPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-- 440

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
             +      + +  TP+H AA ++   +V YL++ G+D++  DK    PL  A S   + 
Sbjct: 441 --NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 498

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGG------RLEDFAASCKDHCE-KSLLQLLN 394
               L+R GA + + D+     LH     G        L+  A   K + +  + L L+ 
Sbjct: 499 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 558

Query: 395 EKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
           E D        G + L  A+++G +  ++ L      IN ++    N +PLH AA Y   
Sbjct: 559 EGDTDIQDLLKGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNL 617

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPL 505
             A  LL+       +N  D  GL PLH A+  GH  +  LL+     ++  D     PL
Sbjct: 618 EVAEYLLEHGAD---VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 674

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMEN 546
           H AA  G T+   LL   H       +++G T L LAT ++
Sbjct: 675 HEAAQKGRTQLCALL-LAHGADPTMKNQEGQTPLDLATADD 714



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 82/337 (24%), Positives = 147/337 (43%), Gaps = 36/337 (10%)

Query: 6   LSTSTKVNLSF----FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTN 61
           LS ST +  S      ++A+++G+++   +L  S+       +GR  T  H A+  N  +
Sbjct: 406 LSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVS 465

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           ++ ++ ++  D++AKD  G  PLH A      +  E L++     +V +     P+H A 
Sbjct: 466 VVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAA 525

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
              K  + ++  K+ +  +  +    G T L      D D      I DL          
Sbjct: 526 AKGKYEICKLLLKHGA--DPTKKNRDGNTPLDLVKEGDTD------IQDL--------LK 569

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG--NVPLHSAVHGGDIKAV 239
           G   + +AAK      +        Q+ CT E  I+  D +G  + PLH A    +++  
Sbjct: 570 GDAALLDAAKKGCLARV--------QKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVA 620

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E  L  GA ++ Q      P+H A + G +DI  L+      + + C+ + D    TP+H
Sbjct: 621 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI-----KYNTCVNATDKWAFTPLH 675

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
            AA     ++   L+  G+D    ++E ++PL LA +
Sbjct: 676 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 712



 Score = 84.6 bits (200), Expect = 2e-15
 Identities = 105/403 (26%), Positives = 168/403 (41%), Gaps = 45/403 (11%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NV+   + G   LH A    H     +L+    A+     N  Y P+HEAA         
Sbjct: 8   NVHARDDGGLIPLHNACSFGHAEVVSLLLCQ-GADPNARDNWNYTPLHEAAIKGKIDVCI 66

Query: 200 VFLQWGEQ---RGCTREQMISLYDNEGNVP----------LHSAVHGGDIKAVELCLRSG 246
           V LQ G     R    +  + L D                L +A  G + K + L     
Sbjct: 67  VLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 126

Query: 247 AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDH 306
                     STP+HLA     + IV+L+      +  A + + D   + P+H A  + H
Sbjct: 127 VNCHASDGRKSTPLHLAAGYNRVRIVQLLL-----QHGADVHAKDKGGLVPLHNACSYGH 181

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            E+   L+  G+ +N +D  + +PL  AAS+        L+  GAD  L + + ++ + +
Sbjct: 182 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 241

Query: 367 VVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACI 426
                 R E      K H   SLLQ               A+RE  +  ++  + L   I
Sbjct: 242 APTPELR-ERLTYEFKGH---SLLQ---------------AAREADLAKVKKTLAL-EII 281

Query: 427 NLKN-NNNESPLH--FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTR 483
           N K   ++E+ LH   A+ + +     +LL   KG   +NE + + +TPLH+A+   H  
Sbjct: 282 NFKQPQSHETALHCAVASLHPKRKQVTELL-LRKGA-NVNEKNKDFMTPLHVAAERAHND 339

Query: 484 VVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           V+ +L   GA ++  D  G+  LH AA++G+ +T  LL S  S
Sbjct: 340 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 382



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 92/371 (24%), Positives = 148/371 (39%), Gaps = 40/371 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AAE  + +D M +     +++   D  G+TA H+A+   +      + +Y  D +     
Sbjct: 332 AAERAH-NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ 390

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T   +   NEA+  I       + TS ++       +   E +K   L+   +  S  
Sbjct: 391 GFTAAQMG--NEAVQQI-LSESTPIRTSDVD-------YRLLEASKAGDLETVKQLCSSQ 440

Query: 140 NVNQGGEHGR--TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           NVN     GR  T LHFAA ++     + L+    A+       G  P+H A        
Sbjct: 441 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEV 499

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ ++ G          +++ D     PLH A   G  +  +L L+ GA  + +  D +
Sbjct: 500 AELLVRHGAS--------VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 551

Query: 258 TPVHLACAQGALDIVKLM---FTMQPKEKHACLT-----------SC-DVQ--KMTPIHC 300
           TP+ L   +G  DI  L+     +    K  CL            +C D Q    TP+H 
Sbjct: 552 TPLDLV-KEGDTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 610

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI+    +   D  +
Sbjct: 611 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 670

Query: 361 RNVLHLVVMNG 371
              LH     G
Sbjct: 671 FTPLHEAAQKG 681



 Score = 68.1 bits (159), Expect = 2e-10
 Identities = 62/201 (30%), Positives = 94/201 (46%), Gaps = 21/201 (10%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRF-----HT 448
           N +DN   +PLH A+ +G I     L++ GA  N++N + +S L  A    +      + 
Sbjct: 43  NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYK 102

Query: 449 ACQLLDSDKG-------------TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
             +LL++ +                  + SDG   TPLH+A+     R+V LLL  GA +
Sbjct: 103 KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADV 162

Query: 496 H-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
           H +D  G  PLH A   G+ +  ELL   H   ++ +D    T LH A  +N+    +LL
Sbjct: 163 HAKDKGGLVPLHNACSYGHYEVTELLLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLL 221

Query: 555 LSMGCRLSYNNM-DMSAIDYA 574
           LS G   +  N    SA+D A
Sbjct: 222 LSHGADPTLVNCHGKSAVDMA 242



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 100/378 (26%), Positives = 158/378 (41%), Gaps = 48/378 (12%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALD--IVKLMFT 277
           D+ G +PLH+A   G  + V L L  GA  + + +   TP+H A  +G +D  IV L   
Sbjct: 13  DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 72

Query: 278 MQPKEKH---------------ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP 322
             P  ++               A LT  + +K   +  A   +  +++  L     + + 
Sbjct: 73  ADPNIRNTDGKSALDLADPSAKAVLTG-EYKKDELLEAARSGNEEKLMALLTPLNVNCHA 131

Query: 323 LDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCK 382
            D  + +PL LAA     R V  L++ GAD+  KD      LH    + G  E      K
Sbjct: 132 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC-SYGHYEVTELLLK 190

Query: 383 DHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
                     +N  D    +PLH A+ +  +     L+  GA   L N + +S +  A  
Sbjct: 191 HGA------CVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPT 244

Query: 443 --------YG-RFHTACQLL-DSD----KGTF---IINESDGEGL-TPLHIASREGHTR- 483
                   Y  + H+  Q   ++D    K T    IIN    +   T LH A    H + 
Sbjct: 245 PELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKR 304

Query: 484 --VVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
             V  LLL +GA ++ ++ +   PLH+AA   +   +E+LH  H   ++ +D  G T+LH
Sbjct: 305 KQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK-HGAKMNALDTLGQTALH 363

Query: 541 LATMENKPSSIALLLSMG 558
            A +     +  LLLS G
Sbjct: 364 RAALAGHLQTCRLLLSYG 381



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 23/235 (9%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           RD  G    H A +  +  ++  +     D NA+DN   TPLH A     +D    LLQ 
Sbjct: 12  RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 71

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
             + ++ N   ++ + +A    K  +   + K + L     G E    A           
Sbjct: 72  GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA----------- 120

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE 222
               L+T L+            P+H AA     R +++ LQ G          +   D  
Sbjct: 121 ----LLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD--------VHAKDKG 168

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
           G VPLH+A   G  +  EL L+ GA ++       TP+H A ++  +++  L+ +
Sbjct: 169 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 223



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 48/162 (29%), Positives = 74/162 (45%), Gaps = 24/162 (14%)

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIAS 477
           +L+++GA ++ +++    PLH A  +G       LL         N  D    TPLH A+
Sbjct: 1   HLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADP---NARDNWNYTPLHEAA 57

Query: 478 REGHTRVVHLLLNRGALLH-RDHNGRNPLHL------AAMSGYTKTIELLHSVHS----- 525
            +G   V  +LL  GA  + R+ +G++ L L      A ++G  K  ELL +  S     
Sbjct: 58  IKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEK 117

Query: 526 --HLLDQID-----KDG--NTSLHLATMENKPSSIALLLSMG 558
              LL  ++      DG  +T LHLA   N+   + LLL  G
Sbjct: 118 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 159



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 9/117 (7%)

Query: 488 LLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMEN 546
           LL  GA +H RD  G  PLH A   G+ + + LL    +   +  D    T LH A ++ 
Sbjct: 2   LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD-PNARDNWNYTPLHEAAIKG 60

Query: 547 KPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEAALAMVTHEQRAKEVM-ALRS 601
           K     +LL  G   +  N D  SA+D A       +A A++T E +  E++ A RS
Sbjct: 61  KIDVCIVLLQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEAARS 112


>AF082556-1|AAC79841.1| 1327|Homo sapiens TRF1-interacting
           ankyrin-related ADP-ribose polymerase protein.
          Length = 1327

 Score =  118 bits (285), Expect = 9e-26
 Identities = 134/524 (25%), Positives = 223/524 (42%), Gaps = 58/524 (11%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++AA SGN +  M L           DGR  T  H A+  N   I+  +  +  D++AKD
Sbjct: 340 LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 399

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G  PLH A      +  E LL+     + ++     P+H A   N+V V  +   + +
Sbjct: 400 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             +      HG++A+  A   +       L   L  E+K       + + +AA+ A    
Sbjct: 460 --DPTLVNCHGKSAVDMAPTPE-------LRERLTYEFKG------HSLLQAAREADLAK 504

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGN-VPLHSAV---HGGDIKAVELCLRSGAKISTQQ 253
           ++  L           ++I+    + +   LH AV   H    +  EL LR GA ++ + 
Sbjct: 505 VKKTLAL---------EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
            D  TP+H+A  +   D+++++       KH A + + D    T +H AA+  H +    
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVL------HKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ GSD + +  +        A++ G   V  ++     I+  D++ R    L     G
Sbjct: 610 LLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR---LLEASKAG 661

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTG--CSPLHYASREGHIRSLENLIRLGACINLKN 430
            LE     C         Q +N +D  G   +PLH+A+    +  +E L+  GA ++ K+
Sbjct: 662 DLETVKQLCSS-------QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD 714

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
                PLH A  YG +  A +LL     +  +N +D    TPLH A+ +G   +  LLL 
Sbjct: 715 KGGLVPLHNACSYGHYEVA-ELLVRHGAS--VNVADLWKFTPLHEAAAKGKYEICKLLLK 771

Query: 491 RGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
            GA    ++ +G  PL L    G T   +LL    + LLD   K
Sbjct: 772 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLKG-DAALLDAAKK 813



 Score =  105 bits (251), Expect = 1e-21
 Identities = 136/591 (23%), Positives = 249/591 (42%), Gaps = 57/591 (9%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++A  +G+V    RL  +         GR  +  H A+     +++  +     +++A+D
Sbjct: 187 LEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           + G  PLH A      + +  LL Q  + +  +     P+H A    K+ V  V  ++ +
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             N+      G++AL  A     D  AK ++T    E+KK        + EAA++ +   
Sbjct: 307 DPNIR--NTDGKSALDLA-----DPSAKAVLT---GEYKKD------ELLEAARSGNEEK 350

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           +   L       C         D   + PLH A     ++ V+L L+ GA +  +     
Sbjct: 351 LMALLT-PLNVNCHAS------DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKH-ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
            P+H AC+ G  ++ +L+       KH AC+ + D+ + TP+H AA  +  E+ + L++ 
Sbjct: 404 VPLHNACSYGHYEVTELLL------KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457

Query: 317 GSDINPLDKERRSPLLLAAS-----RAGWR-TVHTLIRLGADIQLKDINSRNVLHLVVMN 370
           G+D   ++   +S + +A +     R  +    H+L++   +  L  +     L ++   
Sbjct: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK 517

Query: 371 GGRLEDFAASCK----DHCEKSLLQLL-------NEKDNTGCSPLHYASREGHIRSLENL 419
             +  + A  C         K + +LL       NEK+    +PLH A+   H   +E L
Sbjct: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
            + GA +N  +   ++ LH AA  G   T   LL       II+    +G T    A++ 
Sbjct: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL---QGFT----AAQM 630

Query: 480 GHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           G+  V  +L     +   D + R  L  A+ +G  +T++ L S  +     ++   +T L
Sbjct: 631 GNEAVQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPL 688

Query: 540 HLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAMVTH 589
           H A   N+ S +  LL  G  + + +   +  +  A  Y   E A  +V H
Sbjct: 689 HFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 145/581 (24%), Positives = 232/581 (39%), Gaps = 82/581 (14%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVE 89
           ++L L   + +  +D  G    H A +  +  +   +  +   +NA D    TPLH A  
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444

Query: 90  NEALDAIEYLLQQHVETSVLNEKCQAPIHMAT----------ELNKVSVLQV-----FAK 134
              ++    LL    + +++N   ++ + MA           E    S+LQ       AK
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 504

Query: 135 YKS-----LFNVNQGGEHGRTALHFAAIHDHDLCAKI--LITDLDAEWKKPCNNGYYPIH 187
            K      + N  Q   H  TALH A    H    ++  L+    A   +   +   P+H
Sbjct: 505 VKKTLALEIINFKQPQSH-ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLH 563

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            AA+ A +  +EV  + G +        ++  D  G   LH A   G ++   L L  G+
Sbjct: 564 VAAERAHNDVMEVLHKHGAK--------MNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615

Query: 248 K---ISTQ------------QHDLS--TPVHL---------ACAQGALDIVKLMFTMQPK 281
               IS Q            Q  LS  TP+           A   G L+ VK + + Q  
Sbjct: 616 DPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-- 673

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
             +      + +  TP+H AA ++   +V YL++ G+D++  DK    PL  A S   + 
Sbjct: 674 --NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 731

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGG------RLEDFAASCKDHCE-KSLLQLLN 394
               L+R GA + + D+     LH     G        L+  A   K + +  + L L+ 
Sbjct: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 791

Query: 395 EKDN------TGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
           E D        G + L  A+++G +  ++ L      IN ++    N +PLH AA Y   
Sbjct: 792 EGDTDIQDLLKGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNL 850

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPL 505
             A  LL+       +N  D  GL PLH A+  GH  +  LL+     ++  D     PL
Sbjct: 851 EVAEYLLEHGAD---VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMEN 546
           H AA  G T+   LL   H       +++G T L LAT ++
Sbjct: 908 HEAAQKGRTQLCALL-LAHGADPTMKNQEGQTPLDLATADD 947



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 76/282 (26%), Positives = 127/282 (45%), Gaps = 23/282 (8%)

Query: 227 LHSAVHGGDIKAVE-LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           L  A   GD+  V+ L   +           S+P+H A   G  D+V+ +  M      A
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG-----A 240

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            + + D   + P+H A  F H E+V+ L+ +G+D N  D    +PL  AA +        
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300

Query: 346 LIRLGADIQLKDINSRNVLHL------VVMNGG-RLEDFAASCKDHCEKSLLQLL----- 393
           L++ GAD  +++ + ++ L L       V+ G  + ++   + +   E+ L+ LL     
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360

Query: 394 --NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
             +  D    +PLH A+    +R ++ L++ GA ++ K+     PLH A  YG +     
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LL   K    +N  D    TPLH A+ +    V  LLL+ GA
Sbjct: 421 LL---KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 82/337 (24%), Positives = 147/337 (43%), Gaps = 36/337 (10%)

Query: 6   LSTSTKVNLSF----FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTN 61
           LS ST +  S      ++A+++G+++   +L  S+       +GR  T  H A+  N  +
Sbjct: 639 LSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVS 698

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           ++ ++ ++  D++AKD  G  PLH A      +  E L++     +V +     P+H A 
Sbjct: 699 VVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAA 758

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
              K  + ++  K+ +  +  +    G T L      D D      I DL          
Sbjct: 759 AKGKYEICKLLLKHGA--DPTKKNRDGNTPLDLVKEGDTD------IQDL--------LK 802

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG--NVPLHSAVHGGDIKAV 239
           G   + +AAK      +        Q+ CT E  I+  D +G  + PLH A    +++  
Sbjct: 803 GDAALLDAAKKGCLARV--------QKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVA 853

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           E  L  GA ++ Q      P+H A + G +DI  L+      + + C+ + D    TP+H
Sbjct: 854 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI-----KYNTCVNATDKWAFTPLH 908

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
            AA     ++   L+  G+D    ++E ++PL LA +
Sbjct: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 92/371 (24%), Positives = 148/371 (39%), Gaps = 40/371 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AAE  + +D M +     +++   D  G+TA H+A+   +      + +Y  D +     
Sbjct: 565 AAERAH-NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ 623

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T   +   NEA+  I       + TS ++       +   E +K   L+   +  S  
Sbjct: 624 GFTAAQMG--NEAVQQI-LSESTPIRTSDVD-------YRLLEASKAGDLETVKQLCSSQ 673

Query: 140 NVNQGGEHGR--TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           NVN     GR  T LHFAA ++     + L+    A+       G  P+H A        
Sbjct: 674 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEV 732

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ ++ G          +++ D     PLH A   G  +  +L L+ GA  + +  D +
Sbjct: 733 AELLVRHGAS--------VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 784

Query: 258 TPVHLACAQGALDIVKLM---FTMQPKEKHACLT-----------SC-DVQ--KMTPIHC 300
           TP+ L   +G  DI  L+     +    K  CL            +C D Q    TP+H 
Sbjct: 785 TPLDLV-KEGDTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 843

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA +++ E+  YL+  G+D+N  DK    PL  AAS         LI+    +   D  +
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903

Query: 361 RNVLHLVVMNG 371
              LH     G
Sbjct: 904 FTPLHEAAQKG 914


>AB209308-1|BAD92545.1|  931|Homo sapiens ankyrin 3 isoform 1
           variant protein.
          Length = 931

 Score =  114 bits (275), Expect = 2e-24
 Identities = 91/362 (25%), Positives = 162/362 (44%), Gaps = 25/362 (6%)

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G   +H AA++  +  +   +Q G Q        +     +   PLH +   G    V+ 
Sbjct: 10  GETALHMAARSGQAEVVRYLVQDGAQ--------VEAKAKDDQTPLHISARLGKADIVQQ 61

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA 301
            L+ GA  +       TP+HL+  +G  D+   +      +  A L+    +  TP+H A
Sbjct: 62  LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-----DHGASLSITTKKGFTPLHVA 116

Query: 302 AMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSR 361
           A +   E+ N L+ + +  +   K   +PL +AA     +    L+  GA       N  
Sbjct: 117 AKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 176

Query: 362 NVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIR 421
             LH+         D A +  ++   +     N     G + +H A++EGH+  +  L+ 
Sbjct: 177 TPLHIAAKKNQM--DIATTLLEYGADA-----NAVTRQGIASVHLAAQEGHVDMVSLLLG 229

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
             A +NL N +  +PLH AA+  R + A  L+  ++G   ++     G TPLH+    G+
Sbjct: 230 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV--NQGAH-VDAQTKMGYTPLHVGCHYGN 286

Query: 482 TRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLH 540
            ++V+ LL   A ++ +  NG  PLH AA  G+T  I +L   ++   +++  +GNT+L 
Sbjct: 287 IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ-NNASPNELTVNGNTALG 345

Query: 541 LA 542
           +A
Sbjct: 346 IA 347



 Score =  111 bits (267), Expect = 1e-23
 Identities = 87/334 (26%), Positives = 144/334 (43%), Gaps = 17/334 (5%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G   LH A   G  + V   ++ GA++  +  D  TP+H++   G  DIV+ +   Q   
Sbjct: 10  GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL-QQGAS 68

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
            +A  TS      TP+H +A   H ++  +L++ G+ ++   K+  +PL +AA       
Sbjct: 69  PNAATTS----GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 124

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
            + L++  A       +    LH+        +  A    D          N     G +
Sbjct: 125 ANLLLQKSASPDAAGKSGLTPLHVAAHYDN--QKVALLLLDQGASPHAAAKN-----GYT 177

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           PLH A+++  +     L+  GA  N       + +H AA+ G       LL  +     +
Sbjct: 178 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN---V 234

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMSGYTKTIELLH 521
           N S+  GLTPLH+A++E    V  +L+N+GA +      G  PLH+    G  K +  L 
Sbjct: 235 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 294

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             HS  ++   K+G T LH A  +     I +LL
Sbjct: 295 Q-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 327



 Score =  110 bits (265), Expect = 2e-23
 Identities = 92/366 (25%), Positives = 149/366 (40%), Gaps = 25/366 (6%)

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T LH+A  +   + + YL+Q   +     +  Q P+H++  L K  ++Q   +  +  
Sbjct: 10  GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA-- 67

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           + N     G T LH +A   H+  A  L+ D  A        G+ P+H AAK        
Sbjct: 68  SPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVAN 126

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + LQ        +          G  PLH A H  + K   L L  GA       +  TP
Sbjct: 127 LLLQ--------KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 178

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A  +  +DI   +      E  A   +   Q +  +H AA   H ++V+ L+   ++
Sbjct: 179 LHIAAKKNQMDIATTLL-----EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 233

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFA 378
           +N  +K   +PL LAA          L+  GA +  +       LH+    G  ++ +F 
Sbjct: 234 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 293

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
                H  K     +N K   G +PLH A+++GH   +  L++  A  N    N  + L 
Sbjct: 294 LQ---HSAK-----VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 345

Query: 439 FAARYG 444
            A R G
Sbjct: 346 IARRLG 351



 Score =  107 bits (256), Expect = 3e-22
 Identities = 79/345 (22%), Positives = 146/345 (42%), Gaps = 17/345 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA SG  +  +R  + + +++  +    +T  H ++     +I+  +       NA   +
Sbjct: 17  AARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 75

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLH++      D   +LL      S+  +K   P+H+A +  K+ V  +  +  +  
Sbjct: 76  GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-- 133

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           + +  G+ G T LH AA +D+   A +L+ D  A       NGY P+H AAK        
Sbjct: 134 SPDAAGKSGLTPLHVAAHYDNQKVA-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 192

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             L++G        Q        G   +H A   G +  V L L   A ++       TP
Sbjct: 193 TLLEYGADANAVTRQ--------GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 244

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +HLA  +  +++ +++       + A + +      TP+H    + + +IVN+L+   + 
Sbjct: 245 LHLAAQEDRVNVAEVLV-----NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 299

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           +N   K   +PL  AA +     ++ L++  A      +N    L
Sbjct: 300 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 344



 Score =  101 bits (242), Expect = 2e-20
 Identities = 76/267 (28%), Positives = 125/267 (46%), Gaps = 12/267 (4%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H AA     E+V YL+ +G+ +    K+ ++PL ++A       V  L++ GA    
Sbjct: 12  TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 71

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
              +    LHL    G   ED AA   DH   + L +  +K   G +PLH A++ G +  
Sbjct: 72  ATTSGYTPLHLSAREGH--EDVAAFLLDH--GASLSITTKK---GFTPLHVAAKYGKLEV 124

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
              L++  A  +    +  +PLH AA Y     A  LLD         ++   G TPLHI
Sbjct: 125 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN---GYTPLHI 181

Query: 476 ASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKD 534
           A+++    +   LL  GA  +     G   +HLAA  G+   + LL   ++++ +  +K 
Sbjct: 182 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV-NLSNKS 240

Query: 535 GNTSLHLATMENKPSSIALLLSMGCRL 561
           G T LHLA  E++ +   +L++ G  +
Sbjct: 241 GLTPLHLAAQEDRVNVAEVLVNQGAHV 267



 Score = 91.9 bits (218), Expect = 1e-17
 Identities = 73/326 (22%), Positives = 126/326 (38%), Gaps = 16/326 (4%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG TA H A+      ++ ++      + AK     TPLH++      D ++ LLQQ   
Sbjct: 9   RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 68

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            +        P+H++       V      + +  ++    + G T LH AA +     A 
Sbjct: 69  PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT--KKGFTPLHVAAKYGKLEVAN 126

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +L+    A       +G  P+H AA   + +   + L  G       +         G  
Sbjct: 127 LLL-QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK--------NGYT 177

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A     +      L  GA  +         VHLA  +G +D+V L+       ++A
Sbjct: 178 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-----GRNA 232

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            +   +   +TP+H AA  D   +   L+N+G+ ++   K   +PL +       + V+ 
Sbjct: 233 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 292

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNG 371
           L++  A +  K  N    LH     G
Sbjct: 293 LLQHSAKVNAKTKNGYTPLHQAAQQG 318



 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 72/245 (29%), Positives = 112/245 (45%), Gaps = 19/245 (7%)

Query: 326 ERRSPLLLAASRAGW-RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDH 384
           +R    L  A+R+G    V  L++ GA ++ K  + +  LH+    G          K  
Sbjct: 8   QRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG----------KAD 57

Query: 385 CEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAA 441
             + LLQ     N    +G +PLH ++REGH      L+  GA +++      +PLH AA
Sbjct: 58  IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 117

Query: 442 RYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHN 500
           +YG+   A  LL          +S   GLTPLH+A+   + +V  LLL++GA  H    N
Sbjct: 118 KYGKLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN 174

Query: 501 GRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
           G  PLH+AA          L    +   + + + G  S+HLA  E     ++LLL     
Sbjct: 175 GYTPLHIAAKKNQMDIATTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 233

Query: 561 LSYNN 565
           ++ +N
Sbjct: 234 VNLSN 238



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 33/136 (24%), Positives = 62/136 (45%), Gaps = 3/136 (2%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+VD  + L L   + + + +  G T  H A+  +  N+   + N    ++A+   
Sbjct: 215 AAQEGHVD-MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 273

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPLHV      +  + +LLQ   + +   +    P+H A +     ++ V  +  +  
Sbjct: 274 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA-- 331

Query: 140 NVNQGGEHGRTALHFA 155
           + N+   +G TAL  A
Sbjct: 332 SPNELTVNGNTALGIA 347



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 1/125 (0%)

Query: 5   HLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH 64
           +++ S K  L+    AA+   V+    + +++ + +  +   G T  H      N  I++
Sbjct: 233 NVNLSNKSGLTPLHLAAQEDRVN-VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 291

Query: 65  FINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELN 124
           F+  ++  +NAK   G TPLH A +      I  LLQ +   + L       + +A  L 
Sbjct: 292 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 351

Query: 125 KVSVL 129
            +SV+
Sbjct: 352 YISVV 356


>AK091555-1|BAC03695.1|  505|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34236 fis, clone FCBBF3027199, weakly similar to
           ANKYRIN. ).
          Length = 505

 Score =  109 bits (261), Expect = 8e-23
 Identities = 101/365 (27%), Positives = 158/365 (43%), Gaps = 13/365 (3%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           + + D++G   L  A   G  + VE+    GA    ++     TP+H A A G  D + L
Sbjct: 40  LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 99

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +  +   E+       DV   TP+  A M  H + V+ L+ +GS  +  D   R+ L   
Sbjct: 100 L--IDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRG 157

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ--L 392
           A       +  L+   A +  +D   R  +HL    G       A  +   + +L    L
Sbjct: 158 AVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG-----HTAVLRTLLQAALSTDPL 212

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
               D +G SP+H+AS  GH   LE L+       L+ N   +PLH A    +  T   L
Sbjct: 213 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEML 271

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMS 511
           L +  G  I+N  D +G TPLH A+   +   + +LL   A ++  DH GR  L  AA +
Sbjct: 272 LGA-LGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 330

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G T  +E L       L  +D++ NT+LHLA  +       ++L+    L   N   SA+
Sbjct: 331 GQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSAL 390

Query: 572 DYAIY 576
              ++
Sbjct: 391 QMPLH 395



 Score = 97.5 bits (232), Expect = 2e-19
 Identities = 99/402 (24%), Positives = 164/402 (40%), Gaps = 20/402 (4%)

Query: 40  LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGN-TPLHVAVENEALDAIEY 98
           L VRD +GRTA   A+ R +T  +  +  +      K+     TPLH A  +   D++  
Sbjct: 40  LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 99

Query: 99  LLQQHVE---TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFA 155
           L+        T V++   Q P+ +A     V  + +  +  S    +     GRTALH  
Sbjct: 100 LIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKGS--TADAADLRGRTALHRG 157

Query: 156 AIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQM 215
           A+   + C   L+ D DA        G  PIH A+    +  +   L    Q   + + +
Sbjct: 158 AVTGCEDCLAALL-DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL----QAALSTDPL 212

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
            +  D  G  P+H A + G    +EL L   +  S  + +  TP+H A         +++
Sbjct: 213 DAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEML 271

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                 +    + S D +  TP+H AA  D+   +  L+   +++N  D   R+ L+ AA
Sbjct: 272 LGALGAK---IVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAA 328

Query: 336 SRAGWRTVHTLIRLG-ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
                  V  L+  G AD+ + D N    LHL    G        +     E   L L+N
Sbjct: 329 ENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHE----KCALMILAETQDLGLIN 384

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
             ++    PLH A+R G    ++ L+  GA +   +    +P
Sbjct: 385 ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 426



 Score = 90.6 bits (215), Expect = 3e-17
 Identities = 106/425 (24%), Positives = 166/425 (39%), Gaps = 49/425 (11%)

Query: 115 APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAE 174
           +P+H+A        L+  A+  +L N++     GRTAL  A       C ++L     + 
Sbjct: 16  SPLHLAAYNGHCEALKTLAE--TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASA 73

Query: 175 WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGG 234
             K     + P+H AA +  + ++ + +  GE     R  +  + D  G  PL  A+  G
Sbjct: 74  LIKERKRKWTPLHAAAASGHTDSLHLLIDSGE-----RADITDVMDVYGQTPLMLAIMNG 128

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC-DVQ 293
            +  V L L  G+          T +H     G  D +  +        H     C D +
Sbjct: 129 HVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLD------HDAFVLCRDFK 182

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDK----ERRSPLLLAASRAGWRTVHTLIRL 349
             TPIH A+   H  ++  L+      +PLD        SP+  A S  G      L+  
Sbjct: 183 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWA-SYTGHEDCLELLLE 241

Query: 350 GADIQLKDINSRNVLHLVVMNG-----------------------GRLEDFAASCKDHCE 386
            +     + N    LH  V+N                        GR    AA+  D+  
Sbjct: 242 HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVS 301

Query: 387 --KSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHFA 440
             + LLQ    +N  D+TG + L  A+  G   ++E L+  G A + + + N  + LH A
Sbjct: 302 GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLA 361

Query: 441 ARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDH 499
              G    A  +L   +   +IN ++     PLHIA+R G   VV  LL+ GA +L  D 
Sbjct: 362 CSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDE 421

Query: 500 NGRNP 504
            G  P
Sbjct: 422 EGHTP 426



 Score = 84.6 bits (200), Expect = 2e-15
 Identities = 82/345 (23%), Positives = 142/345 (41%), Gaps = 19/345 (5%)

Query: 20  AAESGNVDDFMRLYLS-EPSRLA-VRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           AA SG+ D    L  S E + +  V D  G+T    A    + + +H +       +A D
Sbjct: 88  AAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 147

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK- 136
             G T LH        D +  LL         + K + PIH+A+     +VL+   +   
Sbjct: 148 LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAAL 207

Query: 137 SLFNVNQGGEH-GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           S   ++ G ++ G + +H+A+   H+ C ++L+      + +   N + P+H A  N   
Sbjct: 208 STDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLE--GNPFTPLHCAVINNQD 265

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            T E+ L      G    ++++  D +G  PLH+A    ++  + + L+  A+++   H 
Sbjct: 266 STTEMLL------GALGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 319

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T +  A   G    V+ +         A LT  D  K T +H A    H +    ++ 
Sbjct: 320 GRTALMTAAENGQTAAVEFLL----YRGKADLTVLDENKNTALHLACSKGHEKCALMILA 375

Query: 316 EGSD---INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           E  D   IN  +   + PL +AA       V  L+  GA +   D
Sbjct: 376 ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 420



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 80/322 (24%), Positives = 144/322 (44%), Gaps = 20/322 (6%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A  +G+VD  + L L + S     D RGRTA H+ +     + L  + ++   +  +D  
Sbjct: 124 AIMNGHVD-CVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFK 182

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQ----APIHMATELNKVSVLQVFAKY 135
           G TP+H+A        +  LLQ  + T  L+        +P+H A+       L++  ++
Sbjct: 183 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 242

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAE-WKKPCNNGYYPIHEAAKNAS 194
            S F+  +G     T LH A I++ D   ++L+  L A+        G  P+H AA   +
Sbjct: 243 -SPFSYLEGNPF--TPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADN 299

Query: 195 SRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL-RSGAKISTQQ 253
              + + LQ         +  ++  D+ G   L +A   G   AVE  L R  A ++   
Sbjct: 300 VSGLRMLLQ--------HQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLD 351

Query: 254 HDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
            + +T +HLAC++G  +   LM   + ++    + + +     P+H AA      +V  L
Sbjct: 352 ENKNTALHLACSKGH-EKCALMILAETQDL-GLINATNSALQMPLHIAARNGLASVVQAL 409

Query: 314 INEGSDINPLDKERRSPLLLAA 335
           ++ G+ +  +D+E  +P L  A
Sbjct: 410 LSHGATVLAVDEEGHTPALACA 431



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 11/205 (5%)

Query: 379 ASCKDHCE--KSLLQLL---NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
           A+   HCE  K+L + L   + +D+ G + L  A+  G    +E L   GA   +K    
Sbjct: 21  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 80

Query: 434 E-SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
           + +PLH AA  G   +   L+DS +   I +  D  G TPL +A   GH   VHLLL +G
Sbjct: 81  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKG 140

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           +     D  GR  LH  A++G    +  L    + +L + D  G T +HLA+     + +
Sbjct: 141 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR-DFKGRTPIHLASACGHTAVL 199

Query: 552 ALLLSMGCRLSYNNMDMSAIDYAIY 576
             LL     LS + +D + +DY+ Y
Sbjct: 200 RTLLQ--AALSTDPLD-AGVDYSGY 221



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 79/304 (25%), Positives = 128/304 (42%), Gaps = 18/304 (5%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           +P+HLA   G  + +K +      E    L   D +  T +  A      E V  L   G
Sbjct: 16  SPLHLAAYNGHCEALKTL-----AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHG 70

Query: 318 SDINPLDKERR-SPLLLAASRAGWRTVHTLIRLG--ADI-QLKDINSRNVLHLVVMNGGR 373
           +     +++R+ +PL  AA+     ++H LI  G  ADI  + D+  +  L L +MNG  
Sbjct: 71  ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGH- 129

Query: 374 LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
                  C  H         +  D  G + LH  +  G    L  L+   A +  ++   
Sbjct: 130 -----VDCV-HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKG 183

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINES-DGEGLTPLHIASREGHTRVVHLLLNRG 492
            +P+H A+  G       LL +   T  ++   D  G +P+H AS  GH   + LLL   
Sbjct: 184 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS 243

Query: 493 ALLHRDHNGRNPLHLAAMSGYTKTIE-LLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
              + + N   PLH A ++    T E LL ++ + +++  D  G T LH A   +  S +
Sbjct: 244 PFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVSGL 303

Query: 552 ALLL 555
            +LL
Sbjct: 304 RMLL 307



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 90/387 (23%), Positives = 151/387 (39%), Gaps = 38/387 (9%)

Query: 2   TYIHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTN 61
           T ++L        +    A E G+ +    L     S L     R  T  H A+A  +T+
Sbjct: 36  TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTD 95

Query: 62  ILHFI---NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH 118
            LH +      A   +  D  G TPL +A+ N  +D +  LL++       + + +  +H
Sbjct: 96  SLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH 155

Query: 119 MATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI-----TD-LD 172
                     L     + +   V      GRT +H A+   H    + L+     TD LD
Sbjct: 156 RGAVTGCEDCLAALLDHDAF--VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 213

Query: 173 AEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVH 232
           A       +GY P+H A+       +E+ L+             S  +     PLH AV 
Sbjct: 214 AGVD---YSGYSPMHWASYTGHEDCLELLLE---------HSPFSYLEGNPFTPLHCAVI 261

Query: 233 GGDIKAVELCLRS-GAKI-STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
                  E+ L + GAKI +++     TP+H A     +  ++++   Q     A + + 
Sbjct: 262 NNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQ-----AEVNAT 316

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEG-SDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
           D    T +  AA       V +L+  G +D+  LD+ + + L LA S+   +    ++  
Sbjct: 317 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 376

Query: 350 GADIQLKDINSRN-----VLHLVVMNG 371
             D+ L  IN+ N      LH+   NG
Sbjct: 377 TQDLGL--INATNSALQMPLHIAARNG 401



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 1/92 (1%)

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           ++PLH+A+  GH   +  L      L  RDH GR  L LA   G T+ +E+L +  +  L
Sbjct: 15  VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 74

Query: 529 DQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            +  K   T LH A       S+ LL+  G R
Sbjct: 75  IKERKRKWTPLHAAAASGHTDSLHLLIDSGER 106


>BC101276-1|AAI01277.1|  420|Homo sapiens ANKDD1A protein protein.
          Length = 420

 Score =  106 bits (254), Expect = 5e-22
 Identities = 83/288 (28%), Positives = 130/288 (45%), Gaps = 14/288 (4%)

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++ +++ + SGAKI  +  D  T +H A  +G + +  L F M+  E  A L   D  
Sbjct: 8   GHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPV--LAFIMEDLEDVA-LDHVDKL 64

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
             T  H AA     + +++L+  G D N  DKE  + L LAA R     +  L+ +G D+
Sbjct: 65  GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 124

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           + ++      LH     GG   D           S +  L +K N  C  LHYA+  G  
Sbjct: 125 EEQNAEGLTALHSAA--GGSHPDCVQLLLR--AGSTVNALTQK-NLSC--LHYAALSGSE 177

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
                LI  G C N+ ++   SPLH A R+        L++SD     +N  D    TPL
Sbjct: 178 DVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPL 234

Query: 474 HIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           H+A+      +  +LL  G  L+ RD  G+  L +A  S +   ++++
Sbjct: 235 HLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLVDMI 282



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 66/252 (26%), Positives = 105/252 (41%), Gaps = 14/252 (5%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWK 176
           +H A +   V VL    +      ++   + GRTA H AA H   L A   +     +  
Sbjct: 34  LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ-LDALDFLVGSGCDHN 92

Query: 177 KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
                G   +H AA       ++  +  G       EQ     + EG   LHSA  G   
Sbjct: 93  VKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQ-----NAEGLTALHSAAGGSHP 144

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMT 296
             V+L LR+G+ ++       + +H A   G+ D+ +++          C    D Q  +
Sbjct: 145 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLI-----HAGGCANVVDHQGAS 199

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+H A   + P +V  LIN  SD+N +D  +++PL LAA  A       L+  G D+ L+
Sbjct: 200 PLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR 259

Query: 357 DINSRNVLHLVV 368
           D   +  L + V
Sbjct: 260 DEQGKTALAVAV 271



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 73/267 (27%), Positives = 116/267 (43%), Gaps = 18/267 (6%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN- 359
           +A F H  I+  L+N G+ I+   K+  + L  AA +     +  ++    D+ L  ++ 
Sbjct: 4   SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 63

Query: 360 -SRNVLHLVVMNG--GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
             R   H    +G    L+    S  DH         N KD  G + LH A+  GH+  L
Sbjct: 64  LGRTAFHRAAEHGQLDALDFLVGSGCDH---------NVKDKEGNTALHLAAGRGHMAVL 114

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L+ +G  +  +N    + LH AA  G  H  C  L    G+  +N    + L+ LH A
Sbjct: 115 QRLVDIGLDLEEQNAEGLTALHSAA--GGSHPDCVQLLLRAGS-TVNALTQKNLSCLHYA 171

Query: 477 SREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
           +  G   V  +L++ G   +  DH G +PLHLA    +   + LL +  S  ++ +D   
Sbjct: 172 ALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VNAVDNRQ 230

Query: 536 NTSLHLATMENKPSSIALLLSMGCRLS 562
            T LHLA          +LL  G  L+
Sbjct: 231 QTPLHLAAEHAWQDIADMLLIAGVDLN 257



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 67/228 (29%), Positives = 105/228 (46%), Gaps = 12/228 (5%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           LLL+A     R +  L+  GA I  +  +   +LH     G  +   A   +D  + +L 
Sbjct: 1   LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG-HVPVLAFIMEDLEDVAL- 58

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
              +  D  G +  H A+  G + +L+ L+  G   N+K+    + LH AA  GR H A 
Sbjct: 59  ---DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAA--GRGHMAV 113

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAA 509
                D G   + E + EGLT LH A+   H   V LLL  G+ ++       + LH AA
Sbjct: 114 LQRLVDIG-LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 172

Query: 510 MSGYTKTIELLHSVHS-HLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
           +SG      +L  +H+    + +D  G + LHLA   N P+ + LL++
Sbjct: 173 LSGSEDVSRVL--IHAGGCANVVDHQGASPLHLAVRHNFPALVRLLIN 218



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 68/287 (23%), Positives = 122/287 (42%), Gaps = 18/287 (6%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD--LNAKDNAGNTPLHVA 87
           +++ ++  +++      G T  H A+ + +  +L FI     D  L+  D  G T  H A
Sbjct: 13  LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 72

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
            E+  LDA+++L+    + +V +++    +H+A     ++VLQ         ++ +    
Sbjct: 73  AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAE 130

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TALH AA   H  C ++L+    +            +H AA + S     V +  G  
Sbjct: 131 GLTALHSAAGGSHPDCVQLLLR-AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG-- 187

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
            GC      ++ D++G  PLH AV       V L + S + ++   +   TP+HLA    
Sbjct: 188 -GCA-----NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 241

Query: 268 ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
             DI  ++           L   D Q  T +  A   +H  +V+ +I
Sbjct: 242 WQDIADMLLI-----AGVDLNLRDEQGKTALAVAVRSNHVSLVDMII 283



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 55/238 (23%), Positives = 99/238 (41%), Gaps = 12/238 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D  G    H A   G + A++  + SG   + +  + +T +HLA  +G + +++ +  + 
Sbjct: 62  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 121

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
                  L   + + +T +H AA   HP+ V  L+  GS +N L ++  S L  AA    
Sbjct: 122 LD-----LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 176

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
                 LI  G    + D    + LHL V +     +F A  +          +N  DN 
Sbjct: 177 EDVSRVLIHAGGCANVVDHQGASPLHLAVRH-----NFPALVRLLINSD--SDVNAVDNR 229

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
             +PLH A+        + L+  G  +NL++   ++ L  A R         ++ +D+
Sbjct: 230 QQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKADR 287



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 17/270 (6%)

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL--STPVHLACAQGALDIVKLMFTMQ 279
           +G   LH A   G +  +   +     ++    D    T  H A   G LD   L F + 
Sbjct: 29  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA--LDFLVG 86

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               H      D +  T +H AA   H  ++  L++ G D+   + E  + L  AA  + 
Sbjct: 87  SGCDHNVK---DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 143

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
              V  L+R G+ +      + + LH   ++G             C        N  D+ 
Sbjct: 144 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA-------NVVDHQ 196

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G SPLH A R      +  LI   + +N  +N  ++PLH AA +     A  LL +    
Sbjct: 197 GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD- 255

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLL 489
             +N  D +G T L +A R  H  +V +++
Sbjct: 256 --LNLRDEQGKTALAVAVRSNHVSLVDMII 283



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 12/235 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K+  + F +AAE G +D    L  S      V+D  G TA H A+ R +  +L  + +  
Sbjct: 63  KLGRTAFHRAAEHGQLDALDFLVGSGCDH-NVKDKEGNTALHLAAGRGHMAVLQRLVDIG 121

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            DL  ++  G T LH A      D ++ LL+     + L +K  + +H A       V +
Sbjct: 122 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 181

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V        NV      G + LH A  H+     ++LI   D++     N    P+H AA
Sbjct: 182 VLIHAGGCANVVD--HQGASPLHLAVRHNFPALVRLLINS-DSDVNAVDNRQQTPLHLAA 238

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           ++A     ++ L  G          ++L D +G   L  AV    +  V++ +++
Sbjct: 239 EHAWQDIADMLLIAGVD--------LNLRDEQGKTALAVAVRSNHVSLVDMIIKA 285



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 38/125 (30%), Positives = 63/125 (50%), Gaps = 1/125 (0%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           T+ NLS    AA SG+ +D  R+ +       V D +G +  H A   N   ++  + N 
Sbjct: 161 TQKNLSCLHYAALSGS-EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 219

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D+NA DN   TPLH+A E+   D  + LL   V+ ++ +E+ +  + +A   N VS++
Sbjct: 220 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLV 279

Query: 130 QVFAK 134
            +  K
Sbjct: 280 DMIIK 284



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 14/211 (6%)

Query: 468 EGLTPLHIASREGHTRVVHLL---LNRGALLHRDHNGRNPLHLAAMSGYTKTIE-LLHSV 523
           +GLT LH A+++GH  V+  +   L   AL H D  GR   H AA  G    ++ L+ S 
Sbjct: 29  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 88

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEA 582
             H +   DK+GNT+LHLA      + +  L+ +G  L   N + ++A+  A     P+ 
Sbjct: 89  CDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 146

Query: 583 ALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAV--QDKCITKANCKKDSK-SF 639
              ++   +    V AL      C+  A ++    V   +     C    + +  S    
Sbjct: 147 VQLLL---RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 203

Query: 640 YIKYSFEALCPQLMDEDG-TRKSQQAQQIPL 669
            ++++F AL   L++ D         QQ PL
Sbjct: 204 AVRHNFPALVRLLINSDSDVNAVDNRQQTPL 234



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 3/161 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + +A  G+  D ++L L   S +     +  +  H A+   + ++   + +  G  N  D
Sbjct: 135 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 194

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           + G +PLH+AV +     +  L+    + + ++ + Q P+H+A E     +  +     +
Sbjct: 195 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML--LIA 252

Query: 138 LFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKK 177
             ++N   E G+TAL  A   +H  L   I+  D    W+K
Sbjct: 253 GVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKADRFYRWEK 293


>BC101274-1|AAI01275.1|  423|Homo sapiens ANKDD1A protein protein.
          Length = 423

 Score =  106 bits (254), Expect = 5e-22
 Identities = 83/288 (28%), Positives = 130/288 (45%), Gaps = 14/288 (4%)

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++ +++ + SGAKI  +  D  T +H A  +G + +  L F M+  E  A L   D  
Sbjct: 11  GHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPV--LAFIMEDLEDVA-LDHVDKL 67

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
             T  H AA     + +++L+  G D N  DKE  + L LAA R     +  L+ +G D+
Sbjct: 68  GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           + ++      LH     GG   D           S +  L +K N  C  LHYA+  G  
Sbjct: 128 EEQNAEGLTALHSAA--GGSHPDCVQLLLR--AGSTVNALTQK-NLSC--LHYAALSGSE 180

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
                LI  G C N+ ++   SPLH A R+        L++SD     +N  D    TPL
Sbjct: 181 DVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPL 237

Query: 474 HIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           H+A+      +  +LL  G  L+ RD  G+  L +A  S +   ++++
Sbjct: 238 HLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLVDMI 285



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 66/252 (26%), Positives = 105/252 (41%), Gaps = 14/252 (5%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWK 176
           +H A +   V VL    +      ++   + GRTA H AA H   L A   +     +  
Sbjct: 37  LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ-LDALDFLVGSGCDHN 95

Query: 177 KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
                G   +H AA       ++  +  G       EQ     + EG   LHSA  G   
Sbjct: 96  VKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQ-----NAEGLTALHSAAGGSHP 147

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMT 296
             V+L LR+G+ ++       + +H A   G+ D+ +++          C    D Q  +
Sbjct: 148 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLI-----HAGGCANVVDHQGAS 202

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+H A   + P +V  LIN  SD+N +D  +++PL LAA  A       L+  G D+ L+
Sbjct: 203 PLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR 262

Query: 357 DINSRNVLHLVV 368
           D   +  L + V
Sbjct: 263 DEQGKTALAVAV 274



 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 74/273 (27%), Positives = 118/273 (43%), Gaps = 18/273 (6%)

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
           M  +  +A F H  I+  L+N G+ I+   K+  + L  AA +     +  ++    D+ 
Sbjct: 1   MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60

Query: 355 LKDIN--SRNVLHLVVMNG--GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           L  ++   R   H    +G    L+    S  DH         N KD  G + LH A+  
Sbjct: 61  LDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH---------NVKDKEGNTALHLAAGR 111

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH+  L+ L+ +G  +  +N    + LH AA  G  H  C  L    G+  +N    + L
Sbjct: 112 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAA--GGSHPDCVQLLLRAGS-TVNALTQKNL 168

Query: 471 TPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           + LH A+  G   V  +L++ G   +  DH G +PLHLA    +   + LL +  S  ++
Sbjct: 169 SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VN 227

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
            +D    T LHLA          +LL  G  L+
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLN 260



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 68/287 (23%), Positives = 122/287 (42%), Gaps = 18/287 (6%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD--LNAKDNAGNTPLHVA 87
           +++ ++  +++      G T  H A+ + +  +L FI     D  L+  D  G T  H A
Sbjct: 16  LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 75

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
            E+  LDA+++L+    + +V +++    +H+A     ++VLQ         ++ +    
Sbjct: 76  AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAE 133

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TALH AA   H  C ++L+    +            +H AA + S     V +  G  
Sbjct: 134 GLTALHSAAGGSHPDCVQLLLR-AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG-- 190

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
            GC      ++ D++G  PLH AV       V L + S + ++   +   TP+HLA    
Sbjct: 191 -GCA-----NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 244

Query: 268 ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
             DI  ++           L   D Q  T +  A   +H  +V+ +I
Sbjct: 245 WQDIADMLLI-----AGVDLNLRDEQGKTALAVAVRSNHVSLVDMII 286



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 55/238 (23%), Positives = 99/238 (41%), Gaps = 12/238 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D  G    H A   G + A++  + SG   + +  + +T +HLA  +G + +++ +  + 
Sbjct: 65  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
                  L   + + +T +H AA   HP+ V  L+  GS +N L ++  S L  AA    
Sbjct: 125 LD-----LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 179

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
                 LI  G    + D    + LHL V +     +F A  +          +N  DN 
Sbjct: 180 EDVSRVLIHAGGCANVVDHQGASPLHLAVRH-----NFPALVRLLINSD--SDVNAVDNR 232

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
             +PLH A+        + L+  G  +NL++   ++ L  A R         ++ +D+
Sbjct: 233 QQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKADR 290



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 17/270 (6%)

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL--STPVHLACAQGALDIVKLMFTMQ 279
           +G   LH A   G +  +   +     ++    D    T  H A   G LD   L F + 
Sbjct: 32  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA--LDFLVG 89

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               H      D +  T +H AA   H  ++  L++ G D+   + E  + L  AA  + 
Sbjct: 90  SGCDHNVK---DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 146

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
              V  L+R G+ +      + + LH   ++G             C        N  D+ 
Sbjct: 147 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA-------NVVDHQ 199

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G SPLH A R      +  LI   + +N  +N  ++PLH AA +     A  LL +    
Sbjct: 200 GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD- 258

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLL 489
             +N  D +G T L +A R  H  +V +++
Sbjct: 259 --LNLRDEQGKTALAVAVRSNHVSLVDMII 286



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 12/235 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K+  + F +AAE G +D    L  S      V+D  G TA H A+ R +  +L  + +  
Sbjct: 66  KLGRTAFHRAAEHGQLDALDFLVGSGCDH-NVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            DL  ++  G T LH A      D ++ LL+     + L +K  + +H A       V +
Sbjct: 125 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 184

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V        NV      G + LH A  H+     ++LI   D++     N    P+H AA
Sbjct: 185 VLIHAGGCANVVD--HQGASPLHLAVRHNFPALVRLLINS-DSDVNAVDNRQQTPLHLAA 241

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           ++A     ++ L  G          ++L D +G   L  AV    +  V++ +++
Sbjct: 242 EHAWQDIADMLLIAGVD--------LNLRDEQGKTALAVAVRSNHVSLVDMIIKA 288



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 38/125 (30%), Positives = 63/125 (50%), Gaps = 1/125 (0%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           T+ NLS    AA SG+ +D  R+ +       V D +G +  H A   N   ++  + N 
Sbjct: 164 TQKNLSCLHYAALSGS-EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 222

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D+NA DN   TPLH+A E+   D  + LL   V+ ++ +E+ +  + +A   N VS++
Sbjct: 223 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVSLV 282

Query: 130 QVFAK 134
            +  K
Sbjct: 283 DMIIK 287



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 14/211 (6%)

Query: 468 EGLTPLHIASREGHTRVVHLL---LNRGALLHRDHNGRNPLHLAAMSGYTKTIE-LLHSV 523
           +GLT LH A+++GH  V+  +   L   AL H D  GR   H AA  G    ++ L+ S 
Sbjct: 32  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEA 582
             H +   DK+GNT+LHLA      + +  L+ +G  L   N + ++A+  A     P+ 
Sbjct: 92  CDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 149

Query: 583 ALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAV--QDKCITKANCKKDSK-SF 639
              ++   +    V AL      C+  A ++    V   +     C    + +  S    
Sbjct: 150 VQLLL---RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 206

Query: 640 YIKYSFEALCPQLMDEDG-TRKSQQAQQIPL 669
            ++++F AL   L++ D         QQ PL
Sbjct: 207 AVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 3/161 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + +A  G+  D ++L L   S +     +  +  H A+   + ++   + +  G  N  D
Sbjct: 138 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 197

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           + G +PLH+AV +     +  L+    + + ++ + Q P+H+A E     +  +     +
Sbjct: 198 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML--LIA 255

Query: 138 LFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKK 177
             ++N   E G+TAL  A   +H  L   I+  D    W+K
Sbjct: 256 GVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKADRFYRWEK 296


>BC101275-1|AAI01276.1|  423|Homo sapiens ANKDD1A protein protein.
          Length = 423

 Score =  105 bits (253), Expect = 7e-22
 Identities = 83/288 (28%), Positives = 130/288 (45%), Gaps = 14/288 (4%)

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++ +++ + SGAKI  +  D  T +H A  +G + +  L F M+  E  A L   D  
Sbjct: 11  GHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPV--LAFIMEDLEDVA-LDHVDKL 67

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
             T  H AA     + +++L+  G D N  DKE  + L LAA R     +  L+ +G D+
Sbjct: 68  GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           + ++      LH     GG   D           S +  L +K N  C  LHYA+  G  
Sbjct: 128 EEQNAEGLTALHSAA--GGSHPDCVQLLLR--AGSTVNALTQK-NLSC--LHYAALSGSE 180

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
                LI  G C N+ ++   SPLH A R+        L++SD     +N  D    TPL
Sbjct: 181 DVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPL 237

Query: 474 HIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           H+A+      +  +LL  G  L+ RD  G+  L +A  S +   ++++
Sbjct: 238 HLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI 285



 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 14/264 (5%)

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDI--NPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +T +HCAA   H  ++ +++ +  D+  + +DK  R+    AA       +  L+  G D
Sbjct: 34  LTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCD 93

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
             +KD      LHL    G       A  +   +  L   L E++  G + LH A+   H
Sbjct: 94  HNVKDKEGNTALHLAAGRG-----HMAVLQRLVDIGLD--LEEQNAEGLTALHSAAGGSH 146

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              ++ L+R G+ +N     N S LH+AA  G    +  L+ +     ++   D +G +P
Sbjct: 147 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVV---DHQGASP 203

Query: 473 LHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
           LH+A R     +V LL+N  + ++  D+  + PLHLAA   +    ++L  +    L+  
Sbjct: 204 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML-LIAGVDLNLR 262

Query: 532 DKDGNTSLHLATMENKPSSIALLL 555
           DK G T+L +A   N  S + +++
Sbjct: 263 DKQGKTALAVAVRSNHVSLVDMII 286



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 66/252 (26%), Positives = 105/252 (41%), Gaps = 14/252 (5%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWK 176
           +H A +   V VL    +      ++   + GRTA H AA H   L A   +     +  
Sbjct: 37  LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ-LDALDFLVGSGCDHN 95

Query: 177 KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
                G   +H AA       ++  +  G       EQ     + EG   LHSA  G   
Sbjct: 96  VKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQ-----NAEGLTALHSAAGGSHP 147

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMT 296
             V+L LR+G+ ++       + +H A   G+ D+ +++          C    D Q  +
Sbjct: 148 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLI-----HAGGCANVVDHQGAS 202

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+H A   + P +V  LIN  SD+N +D  +++PL LAA  A       L+  G D+ L+
Sbjct: 203 PLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR 262

Query: 357 DINSRNVLHLVV 368
           D   +  L + V
Sbjct: 263 DKQGKTALAVAV 274



 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 74/273 (27%), Positives = 118/273 (43%), Gaps = 18/273 (6%)

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
           M  +  +A F H  I+  L+N G+ I+   K+  + L  AA +     +  ++    D+ 
Sbjct: 1   MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60

Query: 355 LKDIN--SRNVLHLVVMNG--GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           L  ++   R   H    +G    L+    S  DH         N KD  G + LH A+  
Sbjct: 61  LDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH---------NVKDKEGNTALHLAAGR 111

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH+  L+ L+ +G  +  +N    + LH AA  G  H  C  L    G+  +N    + L
Sbjct: 112 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAA--GGSHPDCVQLLLRAGS-TVNALTQKNL 168

Query: 471 TPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           + LH A+  G   V  +L++ G   +  DH G +PLHLA    +   + LL +  S  ++
Sbjct: 169 SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VN 227

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
            +D    T LHLA          +LL  G  L+
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLN 260



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 68/287 (23%), Positives = 122/287 (42%), Gaps = 18/287 (6%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD--LNAKDNAGNTPLHVA 87
           +++ ++  +++      G T  H A+ + +  +L FI     D  L+  D  G T  H A
Sbjct: 16  LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 75

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
            E+  LDA+++L+    + +V +++    +H+A     ++VLQ         ++ +    
Sbjct: 76  AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAE 133

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TALH AA   H  C ++L+    +            +H AA + S     V +  G  
Sbjct: 134 GLTALHSAAGGSHPDCVQLLLR-AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG-- 190

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
            GC      ++ D++G  PLH AV       V L + S + ++   +   TP+HLA    
Sbjct: 191 -GCA-----NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 244

Query: 268 ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
             DI  ++           L   D Q  T +  A   +H  +V+ +I
Sbjct: 245 WQDIADMLLI-----AGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 286



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 55/238 (23%), Positives = 99/238 (41%), Gaps = 12/238 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D  G    H A   G + A++  + SG   + +  + +T +HLA  +G + +++ +  + 
Sbjct: 65  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
                  L   + + +T +H AA   HP+ V  L+  GS +N L ++  S L  AA    
Sbjct: 125 LD-----LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 179

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
                 LI  G    + D    + LHL V +     +F A  +          +N  DN 
Sbjct: 180 EDVSRVLIHAGGCANVVDHQGASPLHLAVRH-----NFPALVRLLINSD--SDVNAVDNR 232

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
             +PLH A+        + L+  G  +NL++   ++ L  A R         ++ +D+
Sbjct: 233 QQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADR 290



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 17/270 (6%)

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL--STPVHLACAQGALDIVKLMFTMQ 279
           +G   LH A   G +  +   +     ++    D    T  H A   G LD   L F + 
Sbjct: 32  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA--LDFLVG 89

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               H      D +  T +H AA   H  ++  L++ G D+   + E  + L  AA  + 
Sbjct: 90  SGCDHNVK---DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 146

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
              V  L+R G+ +      + + LH   ++G             C        N  D+ 
Sbjct: 147 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA-------NVVDHQ 199

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G SPLH A R      +  LI   + +N  +N  ++PLH AA +     A  LL +    
Sbjct: 200 GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD- 258

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLL 489
             +N  D +G T L +A R  H  +V +++
Sbjct: 259 --LNLRDKQGKTALAVAVRSNHVSLVDMII 286



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 12/235 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K+  + F +AAE G +D    L  S      V+D  G TA H A+ R +  +L  + +  
Sbjct: 66  KLGRTAFHRAAEHGQLDALDFLVGSGCDH-NVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            DL  ++  G T LH A      D ++ LL+     + L +K  + +H A       V +
Sbjct: 125 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 184

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V        NV      G + LH A  H+     ++LI   D++     N    P+H AA
Sbjct: 185 VLIHAGGCANVVD--HQGASPLHLAVRHNFPALVRLLINS-DSDVNAVDNRQQTPLHLAA 241

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRS 245
           ++A     ++ L  G          ++L D +G   L  AV    +  V++ +++
Sbjct: 242 EHAWQDIADMLLIAGVD--------LNLRDKQGKTALAVAVRSNHVSLVDMIIKA 288



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 1/125 (0%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           T+ NLS    AA SG+ +D  R+ +       V D +G +  H A   N   ++  + N 
Sbjct: 164 TQKNLSCLHYAALSGS-EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 222

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
             D+NA DN   TPLH+A E+   D  + LL   V+ ++ +++ +  + +A   N VS++
Sbjct: 223 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 282

Query: 130 QVFAK 134
            +  K
Sbjct: 283 DMIIK 287



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 14/211 (6%)

Query: 468 EGLTPLHIASREGHTRVVHLL---LNRGALLHRDHNGRNPLHLAAMSGYTKTIE-LLHSV 523
           +GLT LH A+++GH  V+  +   L   AL H D  GR   H AA  G    ++ L+ S 
Sbjct: 32  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEA 582
             H +   DK+GNT+LHLA      + +  L+ +G  L   N + ++A+  A     P+ 
Sbjct: 92  CDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 149

Query: 583 ALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAV--QDKCITKANCKKDSK-SF 639
              ++   +    V AL      C+  A ++    V   +     C    + +  S    
Sbjct: 150 VQLLL---RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 206

Query: 640 YIKYSFEALCPQLMDEDG-TRKSQQAQQIPL 669
            ++++F AL   L++ D         QQ PL
Sbjct: 207 AVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 3/161 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + +A  G+  D ++L L   S +     +  +  H A+   + ++   + +  G  N  D
Sbjct: 138 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 197

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           + G +PLH+AV +     +  L+    + + ++ + Q P+H+A E     +  +     +
Sbjct: 198 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML--LIA 255

Query: 138 LFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKK 177
             ++N   + G+TAL  A   +H  L   I+  D    W+K
Sbjct: 256 GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEK 296


>AC017035-2|AAY15060.1|  394|Homo sapiens unknown protein.
          Length = 394

 Score =  103 bits (248), Expect = 3e-21
 Identities = 96/366 (26%), Positives = 155/366 (42%), Gaps = 25/366 (6%)

Query: 40  LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN-AGNTPLHVAVENEALDAIEY 98
           L +RD +GRTA   A+ + +T  +  + N    +  KDN    TPLH +V N     +  
Sbjct: 43  LDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTKRTPLHASVINGHTLCLRL 102

Query: 99  LLQ---QHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFA 155
           LL+         V + K Q P+ +A     +  + +  + ++  NV+     G TALH  
Sbjct: 103 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA--NVDTVDILGCTALHRG 160

Query: 156 AIHDHDLCAKILITDLDAEWKKPC--NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTRE 213
            +  H+ C ++L   L+ E    C  + G  P+H AA    +  +   LQ         E
Sbjct: 161 IMTGHEECVQML---LEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQM-----ALSE 212

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
           +     DN+G  PLH A + G+   +E+ L          +   TP+H A      +   
Sbjct: 213 EDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-TPLHCAIINDHGNCAS 271

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLL 333
           L+         +C    D +  TP+H AA  DH E +  L+   + +N +D   ++ L++
Sbjct: 272 LLLGAIDSSIVSCR---DDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMM 328

Query: 334 AASRAGWRTVHTLIRLG-ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL 392
           AA       V  L+    AD+ +KD +    LHL    G   E  A    D  +     L
Sbjct: 329 AAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH--EKCALLILDKIQDE--SL 384

Query: 393 LNEKDN 398
           +NEK+N
Sbjct: 385 INEKNN 390



 Score =  103 bits (247), Expect = 4e-21
 Identities = 99/378 (26%), Positives = 160/378 (42%), Gaps = 28/378 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H AA N   + +EV LQ            + + D +G   L  A   G  + VE  + 
Sbjct: 20  PLHLAAYNGHHQALEVLLQSLVD--------LDIRDEKGRTALDLAAFKGHTECVEALIN 71

Query: 245 SGAKISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
            GA I  + +    TP+H +   G    ++L+  ++  +    +   D +  TP+  A  
Sbjct: 72  QGASIFVKDNVTKRTPLHASVINGHTLCLRLL--LEIADNPEAVDVKDAKGQTPLMLAVA 129

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
           + H + V+ L+ + ++++ +D    + L           V  L+     I  KD   R  
Sbjct: 130 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTP 189

Query: 364 LHLVVMNG-----GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLEN 418
           LH     G       L   A S +D C K         DN G +PLH+A   G+   +E 
Sbjct: 190 LHYAAARGHATWLSELLQMALSEEDCCFK---------DNQGYTPLHWACYNGNENCIEV 240

Query: 419 LIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR 478
           L+    C      N  +PLH A      + A  LL +   + I++  D +G TPLH A+ 
Sbjct: 241 LLEQ-KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSS-IVSCRDDKGRTPLHAAAF 298

Query: 479 EGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
             H   + LLL   A ++  D++G+  L +AA +G    +++L +     L   DKD NT
Sbjct: 299 ADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNT 358

Query: 538 SLHLATMENKPSSIALLL 555
            LHLA  +       L+L
Sbjct: 359 PLHLACSKGHEKCALLIL 376



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 98/380 (25%), Positives = 157/380 (41%), Gaps = 56/380 (14%)

Query: 149 RTALHFAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           ++ LH AA + H    ++L+    DLD   +K    G   +  AA    +  +E  +  G
Sbjct: 18  KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK----GRTALDLAAFKGHTECVEALINQG 73

Query: 206 EQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLR---SGAKISTQQHDLSTPVH 261
                     I + DN     PLH++V  G    + L L    +   +  +     TP+ 
Sbjct: 74  AS--------IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 125

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           LA A G +D V L+      EK A + + D+   T +H   M  H E V  L+ +   I 
Sbjct: 126 LAVAYGHIDAVSLLL-----EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 180

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGA---DIQLKDINSRNVLHLVVMNGGR----- 373
             D   R+PL  AA+R     +  L+++     D   KD      LH    NG       
Sbjct: 181 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 240

Query: 374 -LED--------------FAASCKDH--CEKSLLQLLNE-----KDNTGCSPLHYASREG 411
            LE                 A   DH  C   LL  ++      +D+ G +PLH A+   
Sbjct: 241 LLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFAD 300

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
           H+  L+ L+R  A +N  +N+ ++ L  AA  G+      L++S +    + + D    T
Sbjct: 301 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN--T 358

Query: 472 PLHIASREGHTRVVHLLLNR 491
           PLH+A  +GH +   L+L++
Sbjct: 359 PLHLACSKGHEKCALLILDK 378



 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 96/405 (23%), Positives = 159/405 (39%), Gaps = 30/405 (7%)

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVL 129
           +G   +   A  +PLH+A  N    A+E LLQ  V+  + +EK +  + +A        +
Sbjct: 7   SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 66

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIH 187
           +      +   V       RT LH + I+ H LC ++L+   D        +  G  P+ 
Sbjct: 67  EALINQGASIFVKDNVTK-RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 125

Query: 188 EAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
            A        + + L+        +E  +   D  G   LH  +  G  + V++ L    
Sbjct: 126 LAVAYGHIDAVSLLLE--------KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 177

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHP 307
            I  +     TP+H A A+G    +  +  M   E+  C    D Q  TP+H A    + 
Sbjct: 178 SILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFK--DNQGYTPLHWACYNGNE 235

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
             +  L+ E            +PL  A           L  LGA I    ++ R+     
Sbjct: 236 NCIEVLL-EQKCFRKFIGNPFTPLHCAIINDHGNCASLL--LGA-IDSSIVSCRD----- 286

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRL 422
             + GR    AA+  DH E   L L     +N  DN+G + L  A+  G   +++ L+  
Sbjct: 287 --DKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 344

Query: 423 G-ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
             A + +K+ +  +PLH A   G    A  +LD  +   +INE +
Sbjct: 345 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKN 389



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 64/298 (21%), Positives = 129/298 (43%), Gaps = 21/298 (7%)

Query: 37  PSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAI 96
           P  + V+D +G+T    A A  + + +  +     +++  D  G T LH  +     + +
Sbjct: 110 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 169

Query: 97  EYLLQQHVETSVLNEKCQAPIHMATELNKVS----VLQV-FAKYKSLFNVNQGGEHGRTA 151
           + LL+Q V     + + + P+H A      +    +LQ+  ++    F  NQ    G T 
Sbjct: 170 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ----GYTP 225

Query: 152 LHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCT 211
           LH+A  + ++ C ++L+      ++K   N + P+H A  N       + L      G  
Sbjct: 226 LHWACYNGNENCIEVLLE--QKCFRKFIGNPFTPLHCAIINDHGNCASLLL------GAI 277

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
              ++S  D++G  PLH+A     ++ ++L LR  A ++   +   T + +A   G    
Sbjct: 278 DSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 337

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           V ++         A LT  D    TP+H A    H +    ++++  D + ++++  +
Sbjct: 338 VDILV----NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNA 391



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 63/246 (25%), Positives = 106/246 (43%), Gaps = 18/246 (7%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D + L L + + +   D  G TA H+     +   +  +      +  KD+ G TPLH A
Sbjct: 134 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 193

Query: 88  VENEALDAIEYLLQQHV---ETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQG 144
                   +  LLQ  +   +    + +   P+H A      + ++V  + K  F    G
Sbjct: 194 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK-CFRKFIG 252

Query: 145 GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPC--NNGYYPIHEAAKNASSRTIEVFL 202
                T LH A I+DH  CA +L+  +D+     C  + G  P+H AA       +++ L
Sbjct: 253 NPF--TPLHCAIINDHGNCASLLLGAIDSSIVS-CRDDKGRTPLHAAAFADHVECLQLLL 309

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPVH 261
           +            ++  DN G   L  A   G   AV++ + S  A ++ +  DL+TP+H
Sbjct: 310 R--------HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 361

Query: 262 LACAQG 267
           LAC++G
Sbjct: 362 LACSKG 367



 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 89/397 (22%), Positives = 154/397 (38%), Gaps = 31/397 (7%)

Query: 45  GRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHV 104
           G  ++  H A+   +   L  +     DL+ +D  G T L +A      + +E L+ Q  
Sbjct: 15  GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGA 74

Query: 105 ETSVL-NEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALHFAAIHDHDL 162
              V  N   + P+H +        L++  +   +   V+     G+T L  A  + H +
Sbjct: 75  SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH-I 133

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE 222
            A  L+ + +A        G   +H          +++ L+        +E  I   D+ 
Sbjct: 134 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLE--------QEVSILCKDSR 185

Query: 223 GNVPLHSAVHGGDIKAVELCLR---SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           G  PLH A   G    +   L+   S      + +   TP+H AC  G  + ++++    
Sbjct: 186 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL--- 242

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN--EGSDINPLDKERRSPLLLAASR 337
              +  C         TP+HCA + DH    + L+   + S ++  D + R+PL  AA  
Sbjct: 243 ---EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFA 299

Query: 338 AGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
                +  L+R  A +   D + +  L +   NG       A   D    S    L  KD
Sbjct: 300 DHVECLQLLLRHSAPVNAVDNSGKTALMMAAENG------QAGAVDILVNSAQADLTVKD 353

Query: 398 NTGCSPLHYASREGHIRS---LENLIRLGACINLKNN 431
               +PLH A  +GH +    + + I+  + IN KNN
Sbjct: 354 KDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 390



 Score = 68.5 bits (160), Expect = 1e-10
 Identities = 59/220 (26%), Positives = 96/220 (43%), Gaps = 12/220 (5%)

Query: 27  DDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA---GDLNAKDNAGNTP 83
           ++ +++ L +   +  +D RGRT  H A+AR +   L  +   A    D   KDN G TP
Sbjct: 166 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 225

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A  N   + IE LL+Q      +      P+H A   +  +   +         V+ 
Sbjct: 226 LHWACYNGNENCIEVLLEQKCFRKFIGNPF-TPLHCAIINDHGNCASLLLGAIDSSIVSC 284

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQ 203
             + GRT LH AA  DH  C ++L+    A      N+G   +  AA+N  +  +++ + 
Sbjct: 285 RDDKGRTPLHAAAFADHVECLQLLLRH-SAPVNAVDNSGKTALMMAAENGQAGAVDILVN 343

Query: 204 WGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
                  + +  +++ D + N PLH A   G  K   L L
Sbjct: 344 -------SAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 376



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 31/96 (32%), Positives = 49/96 (51%), Gaps = 2/96 (2%)

Query: 464 ESD-GEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLH 521
           ESD G   +PLH+A+  GH + + +LL     L  RD  GR  L LAA  G+T+ +E L 
Sbjct: 11  ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 70

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           +  + +  + +    T LH + +      + LLL +
Sbjct: 71  NQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI 106


>AY281131-1|AAP37612.1| 1249|Homo sapiens AIDA-1b protein.
          Length = 1249

 Score =  103 bits (246), Expect = 5e-21
 Identities = 72/229 (31%), Positives = 104/229 (45%), Gaps = 14/229 (6%)

Query: 140 NVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G TALH AA++ H D+  K+L    +A      N GY+PIH AA       +
Sbjct: 51  NVNCTDSSGYTALHHAALNGHKDIVLKLL--QYEASTNVADNKGYFPIHLAAWKGDVEIV 108

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           ++ +  G       EQ     +NE    LH A   G  + V + L      + +   L T
Sbjct: 109 KILIHHGPSHSRVNEQ-----NNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           P+ LA   G L +VK++ +  P      L SC+ +K TP+H AA   H  +V  L+  G 
Sbjct: 164 PLDLAALYGRLRVVKMIISAHPN-----LMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM 218

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           D++    E+ S L  AA       V  L+  G D  +KD   R VL ++
Sbjct: 219 DVS-CQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDIL 266



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 53/186 (28%), Positives = 89/186 (47%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D++G + LH+A+  GH   +  L++  A  N+ +N    P+H AA  G       L
Sbjct: 52  VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + E  T LH A++ GH+ VV +LL        R+     PL LAA+ 
Sbjct: 112 IHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALY 171

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + ++++ S H +L+   +   +T LHLA      + + +LL  G  +S      SA+
Sbjct: 172 GRLRVVKMIISAHPNLM-SCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230

Query: 572 DYAIYY 577
             A  +
Sbjct: 231 HEAALF 236



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 52/205 (25%), Positives = 93/205 (45%), Gaps = 11/205 (5%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D++G T LH A  N   D +  LLQ    T+V + K   PIH+A     V ++++
Sbjct: 51  NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110

Query: 132 FAKY-KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
              +  S   VN+      TALH AA + H     +L+ +L     +  +    P+  AA
Sbjct: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRN-SKLETPLDLAA 169

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS 250
                R +++ +            ++S  +   + PLH A   G    V++ L +G  +S
Sbjct: 170 LYGRLRVVKMIIS-------AHPNLMSC-NTRKHTPLHLAARNGHKAVVQVLLEAGMDVS 221

Query: 251 TQQHDLSTPVHLACAQGALDIVKLM 275
            Q  +  + +H A   G +D+V+++
Sbjct: 222 CQT-EKGSALHEAALFGKVDVVRVL 245



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 2/156 (1%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           ++  D+ G   LH A   G    V   L+  A  +   +    P+HLA  +G ++IVK++
Sbjct: 52  VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
               P   H+ +   + +  T +HCAA + H E+V  L+ E +D    + +  +PL LAA
Sbjct: 112 IHHGPS--HSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAA 169

Query: 336 SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
                R V  +I    ++   +      LHL   NG
Sbjct: 170 LYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNG 205



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 38/128 (29%), Positives = 61/128 (47%), Gaps = 3/128 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +NE++N   + LH A++ GH   +  L+       ++N+  E+PL  AA YGR      +
Sbjct: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSG 512
           + +       N       TPLH+A+R GH  VV +LL  G  +       + LH AA+ G
Sbjct: 181 ISAHPNLMSCNTRKH---TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFG 237

Query: 513 YTKTIELL 520
               + +L
Sbjct: 238 KVDVVRVL 245



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 42/181 (23%), Positives = 77/181 (42%), Gaps = 8/181 (4%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ-- 101
           D  G TA H A+   + +I+  +  Y    N  DN G  P+H+A     ++ ++ L+   
Sbjct: 56  DSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHG 115

Query: 102 -QHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N + +  +H A +     V+ V    + L +         T L  AA++  
Sbjct: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVL--LEELTDPTIRNSKLETPLDLAALYGR 173

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K++I+         CN   + P+H AA+N     ++V L+ G    C  E+  +L+
Sbjct: 174 LRVVKMIISAHPN--LMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALH 231

Query: 220 D 220
           +
Sbjct: 232 E 232



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 8/202 (3%)

Query: 7   STSTKVNLSFFV--QAAESGNVDDFMRLYLSEPS--RLAVRDGRGRTAAHQASARNNTNI 62
           ST+   N  +F    AA  G+V+    L    PS  R+  ++    TA H A+   ++ +
Sbjct: 84  STNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEV 143

Query: 63  LHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE 122
           +  +     D   +++   TPL +A     L  ++ ++  H      N +   P+H+A  
Sbjct: 144 VAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAAR 203

Query: 123 LNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNN 181
               +V+QV    ++  +V+   E G +ALH AA+    D+   +L T +DA  K     
Sbjct: 204 NGHKAVVQVL--LEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGR 260

Query: 182 GYYPIHEAAKNASSRTIEVFLQ 203
               I +   +  S  I   LQ
Sbjct: 261 TVLDILKEHPSQKSLQIATLLQ 282


>BC004173-1|AAH04173.1| 1500|Homo sapiens ANKRD17 protein protein.
          Length = 1500

 Score =  102 bits (245), Expect = 7e-21
 Identities = 93/334 (27%), Positives = 152/334 (45%), Gaps = 24/334 (7%)

Query: 220  DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALDIVKLMFTM 278
            D +G  PL  A   G +  VE+ L +GA I  Q +    TP+ LAC+ G  ++V+L+   
Sbjct: 1113 DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 1172

Query: 279  QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR--SPLLLAAS 336
               ++H      +V   TP+  AA   +  I+  L+N G++IN     +   SPL+LAA 
Sbjct: 1173 GANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227

Query: 337  RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEK 396
                  V  L+ +G+DI  +   +RN    +    GR E  +              +  +
Sbjct: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN------VEHR 1281

Query: 397  DNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRFHTACQLLD 454
              TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +   C+LL 
Sbjct: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF-CELLI 1340

Query: 455  SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPLHLAAMSGY 513
              +G  I +  + +G TPL +A+  GH  VV LL+  GA +    N +  PL  A   G+
Sbjct: 1341 G-RGAHI-DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 514  TKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
             K +  L       ++Q   D     ++AT+ +K
Sbjct: 1399 VKVVRYLVKE----VNQFPSDSECMRYIATITDK 1428



 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 125/500 (25%), Positives = 202/500 (40%), Gaps = 34/500 (6%)

Query: 78  NAG---NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           NAG   N  L  A     ++A+  LL +    +   E+ ++ + +A       + QV   
Sbjct: 229 NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288

Query: 135 YKSLFNVNQGGEHGR-TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
             +  NV   G  G  T L  AA   H    K+L+    A+     + G   +  A    
Sbjct: 289 MHA--NVEDRGIKGDITPLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGG 345

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
               ++V L+ G          I  ++  G+ PL  A   G ++   L L +GA I+T  
Sbjct: 346 YVDVVKVLLESGAS--------IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397

Query: 254 HDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
           ++   + + LAC +G L++V+ +      ++H      D +  T +  A M  H E+   
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEH----KTD-EMHTALMEACMDGHVEVARL 452

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ G+ +N       SPL LAA          LI  GA   L+++N      L+     
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS--LEEVNDEGYTPLMEAARE 510

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
             E+  A           Q     + T  + L  A   G +   + LI+ GA I L    
Sbjct: 511 GHEEMVALLLGQGANINAQT----EETQETALTLACCGGFLEVADFLIKAGADIEL---G 563

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PL  AA+ G       LL +      ++ +   G T L  A   GHT V  +LL  G
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGAN---VHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A L H    GR PL  AA +G+  T++ L S  +++      + +T L LA      + +
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680

Query: 552 ALLLSMGCRLSYNNMDMSAI 571
            LLL+ G   ++   D S +
Sbjct: 681 ELLLAHGADPTHRLKDGSTM 700



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 80/274 (29%), Positives = 123/274 (44%), Gaps = 12/274 (4%)

Query: 296  TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
            T +  A    H E+V  L+  G+ I   DK+  +PL+LAA+      V  L+  GADI+ 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 356  KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
            +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++  
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANK---EHRNVSDYT---PLSLAASGGYVNI 1198

Query: 416  LENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            ++ L+  GA IN +  +    SPL  AA  G  HTA   L  D G+ I  + +    T L
Sbjct: 1199 IKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETNRNTAL 1256

Query: 474  HIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQI 531
             +A  +G T VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    +
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316

Query: 532  DKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
                +T+L +A  +       LL+  G  +   N
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1350



 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 102/437 (23%), Positives = 175/437 (40%), Gaps = 26/437 (5%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+   +  I+  +  +  D+NA+ + GNT L  A     +D ++ LL+        NE  
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
             P+  A     V V ++  +  +  N +   E   +AL  A    H    + L+ +  A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLL-EAGA 425

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           + +   +  +  + EA  +       + L  G Q        +++  +    PL  A  G
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAACG 477

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A        
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG-QGANINAQTEETQET 536

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
            +T   C       E+ ++LI  G+DI   +    +PL+ AA       V  L+  GA++
Sbjct: 537 ALTLACCGGFL---EVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANV 590

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
                     L     NG    D A    D   ++   L +E +  G +PL  A+R GH+
Sbjct: 591 HATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAARAGHV 643

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            +++ LI  GA +N    NN+  +   A  G      +LL +          DG   T L
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS--TML 701

Query: 474 HIASREGHTRVVHLLLN 490
             A++ GHT VV  LL+
Sbjct: 702 IEAAKGGHTSVVCYLLD 718



 Score = 71.7 bits (168), Expect = 1e-11
 Identities = 100/464 (21%), Positives = 182/464 (39%), Gaps = 28/464 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K +++  + AA  G+V   ++L L+  + +  +   G TA   A A    +++  +    
Sbjct: 299 KGDITPLMAAANGGHVK-IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVL 129
             +   +  G+TPL  A     ++    LL+     +   NE  ++ + +A     + ++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
           +   +  +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  A
Sbjct: 418 RFLLEAGA--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLA 474

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A         + +    +RG + E++    ++EG  PL  A   G  + V L L  GA I
Sbjct: 475 ACGGHVELAALLI----ERGASLEEV----NDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 250 STQQHDL-STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           + Q  +   T + LAC  G L++   +       +  C         TP+  AA   H E
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--------STPLMEAAQEGHLE 578

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +V YL+  G++++       + L  A           L++ GAD++ +    R  L    
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL---- 634

Query: 369 MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           M   R      + +    K    +     N   + L  A   GH+  +E L+  GA    
Sbjct: 635 MKAAR-AGHVCTVQFLISKG-ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTH 692

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           +  +  + L  AA+ G     C LLD           D   LTP
Sbjct: 693 RLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 736



 Score = 62.9 bits (146), Expect = 6e-09
 Identities = 77/305 (25%), Positives = 122/305 (40%), Gaps = 16/305 (5%)

Query: 220  DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
            ++  +  L  A  GG  + V+  L  GA I  +     TP+ LA   G + +V+++    
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139

Query: 280  PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               +       +  K TP+  A      E+V  L+  G++    +    +PL LAAS   
Sbjct: 1140 ADIE----AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 1195

Query: 340  WRTVHTLIRLGADIQLKDINSRNV--LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
               +  L+  GA+I  +  +   +  L L  MNG      A          +   +    
Sbjct: 1196 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG---HTAAVKLLLDMGSDINAQIETNR 1252

Query: 398  NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
            NT    L  A  +G    +  L+   A +  +     +PL  AA  G       LL  DK
Sbjct: 1253 NTA---LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL--DK 1307

Query: 458  GTFI-INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTK 515
            G  +          T L IA+ +GH +   LL+ RGA +  R+  G  PL LAA  G+  
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367

Query: 516  TIELL 520
             ++LL
Sbjct: 1368 VVQLL 1372



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 73/313 (23%), Positives = 136/313 (43%), Gaps = 31/313 (9%)

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            ++    + G T L  AA   H    +IL+    D++A+ ++  +    P+  A       
Sbjct: 1108 SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDT---PLSLACSGGRQE 1164

Query: 197  TIEVFLQWGEQRGCTREQM-ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
             +E+ L     RG  +E   +S Y      PL  A  GG +  +++ L +GA+I+++   
Sbjct: 1165 VVELLLA----RGANKEHRNVSDY-----TPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215

Query: 256  LS--TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
                +P+ LA   G    VKL+  M            +  + T +  A      E+V+ L
Sbjct: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDIN----AQIETNRNTALTLACFQGRTEVVSLL 1271

Query: 314  INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDI-NSRNVLHLVVMNGG 372
            ++  +++    K   +PL+ AAS         L+  GAD+    + +SR+    +  + G
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331

Query: 373  RLEDFAASCKDHCEKSL-LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
              +     C+    +   + + N+K NT   PL  A+  GH+  ++ L++ GA ++  +N
Sbjct: 1332 HYK----FCELLIGRGAHIDVRNKKGNT---PLWLAANGGHLDVVQLLVQAGADVDAADN 1384

Query: 432  NNESPLHFAARYG 444
               +PL  A R G
Sbjct: 1385 RKITPLMAAFRKG 1397



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 33/97 (34%), Positives = 50/97 (51%), Gaps = 1/97 (1%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
            T L +A   GH  +V  LL RGA + HRD  G  PL LAA +G+   +E+L    + +  
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 530  QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
            Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181



 Score = 52.8 bits (121), Expect = 7e-06
 Identities = 68/313 (21%), Positives = 122/313 (38%), Gaps = 18/313 (5%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL    +   
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 109  LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             +E+ +  P+ +A    +  V+++     +  N         T L  AA   +    KIL
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 1202

Query: 168  IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
            +    +   +     G  P+  AA N  +  +++ L  G       E          N  
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE-------TNRNTA 1255

Query: 227  LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
            L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 1256 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 1310

Query: 287  LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
            + +  V   + T +  AA   H +    LI  G+ I+  +K+  +PL LAA+      V 
Sbjct: 1311 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370

Query: 345  TLIRLGADIQLKD 357
             L++ GAD+   D
Sbjct: 1371 LLVQAGADVDAAD 1383



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23   SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
            SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 1159 SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218

Query: 81   NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             +PL +A  N    A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA-- 1276

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 1325

Query: 200  VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +    G  + C     R   I + + +GN PL  A +GG +  V+L +++GA +    + 
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 256  LSTPVHLACAQGALDIVKLM 275
              TP+  A  +G + +V+ +
Sbjct: 1386 KITPLMAAFRKGHVKVVRYL 1405



 Score = 35.9 bits (79), Expect = 0.85
 Identities = 20/83 (24%), Positives = 40/83 (48%), Gaps = 1/83 (1%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA+ G+   F  L +   + + VR+ +G T    A+   + +++  +     D++A DN 
Sbjct: 1327 AADKGHYK-FCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 80   GNTPLHVAVENEALDAIEYLLQQ 102
              TPL  A     +  + YL+++
Sbjct: 1386 KITPLMAAFRKGHVKVVRYLVKE 1408



 Score = 35.5 bits (78), Expect = 1.1
 Identities = 25/117 (21%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A+ + +      +      ++ ++  GNTPL +A     LD ++ L+Q   +   
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381

Query: 109  LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
             + +   P+  A     V V++   K      VNQ         + A I D ++  K
Sbjct: 1382 ADNRKITPLMAAFRKGHVKVVRYLVK-----EVNQFPSDSECMRYIATITDKEMLKK 1433


>AK025859-1|BAB15260.1|  460|Homo sapiens protein ( Homo sapiens
           cDNA: FLJ22206 fis, clone HRC01431. ).
          Length = 460

 Score =  102 bits (245), Expect = 7e-21
 Identities = 93/334 (27%), Positives = 152/334 (45%), Gaps = 24/334 (7%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALDIVKLMFTM 278
           D +G  PL  A   G +  VE+ L +GA I  Q +    TP+ LAC+ G  ++V+L+   
Sbjct: 77  DKKGFTPLILAATAGHVGVVEILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 136

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR--SPLLLAAS 336
              ++H      +V   TP+  AA   +  I+  L+N G++IN     +   SPL+LAA 
Sbjct: 137 GANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 191

Query: 337 RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEK 396
                 V  L+ +G+DI  +   +RN    +    GR E  +              +  +
Sbjct: 192 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN------VEHR 245

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRFHTACQLLD 454
             TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +   C+LL 
Sbjct: 246 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF-CELLI 304

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPLHLAAMSGY 513
             +G  I +  + +G TPL +A+  GH  VV LL+  GA +    N +  PL  A   G+
Sbjct: 305 G-RGAHI-DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 362

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
            K +  L       ++Q   D     ++AT+ +K
Sbjct: 363 VKVVRYLVKE----VNQFPSDSECMRYIATITDK 392



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 80/274 (29%), Positives = 123/274 (44%), Gaps = 12/274 (4%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +  A    H E+V  L+  G+ I   DK+  +PL+LAA+      V  L+  GADI+ 
Sbjct: 49  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEA 108

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++  
Sbjct: 109 QSERTKDTPLSLACSGGRQEVVELLLARGANK---EHRNVSDYT---PLSLAASGGYVNI 162

Query: 416 LENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
           ++ L+  GA IN +  +    SPL  AA  G  HTA   L  D G+ I  + +    T L
Sbjct: 163 IKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETNRNTAL 220

Query: 474 HIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQI 531
            +A  +G T VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    +
Sbjct: 221 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 280

Query: 532 DKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
               +T+L +A  +       LL+  G  +   N
Sbjct: 281 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 314



 Score = 62.5 bits (145), Expect = 9e-09
 Identities = 77/305 (25%), Positives = 122/305 (40%), Gaps = 16/305 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           ++  +  L  A  GG  + V+  L  GA I  +     TP+ LA   G + +V+++    
Sbjct: 44  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNG 103

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              +       +  K TP+  A      E+V  L+  G++    +    +PL LAAS   
Sbjct: 104 ADIE----AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 159

Query: 340 WRTVHTLIRLGADIQLKDINSRNV--LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
              +  L+  GA+I  +  +   +  L L  MNG      A          +   +    
Sbjct: 160 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG---HTAAVKLLLDMGSDINAQIETNR 216

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           NT    L  A  +G    +  L+   A +  +     +PL  AA  G       LL  DK
Sbjct: 217 NTA---LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL--DK 271

Query: 458 GTFI-INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTK 515
           G  +          T L IA+ +GH +   LL+ RGA +  R+  G  PL LAA  G+  
Sbjct: 272 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 331

Query: 516 TIELL 520
            ++LL
Sbjct: 332 VVQLL 336



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 73/313 (23%), Positives = 136/313 (43%), Gaps = 31/313 (9%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           ++    + G T L  AA   H    +IL+    D++A+ ++  +    P+  A       
Sbjct: 72  SIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEAQSERTKDT---PLSLACSGGRQE 128

Query: 197 TIEVFLQWGEQRGCTREQM-ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +E+ L     RG  +E   +S Y      PL  A  GG +  +++ L +GA+I+++   
Sbjct: 129 VVELLLA----RGANKEHRNVSDY-----TPLSLAASGGYVNIIKILLNAGAEINSRTGS 179

Query: 256 LS--TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
               +P+ LA   G    VKL+  M            +  + T +  A      E+V+ L
Sbjct: 180 KLGISPLMLAAMNGHTAAVKLLLDMGSDIN----AQIETNRNTALTLACFQGRTEVVSLL 235

Query: 314 INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDI-NSRNVLHLVVMNGG 372
           ++  +++    K   +PL+ AAS         L+  GAD+    + +SR+    +  + G
Sbjct: 236 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 295

Query: 373 RLEDFAASCKDHCEKSL-LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
             +     C+    +   + + N+K NT   PL  A+  GH+  ++ L++ GA ++  +N
Sbjct: 296 HYK----FCELLIGRGAHIDVRNKKGNT---PLWLAANGGHLDVVQLLVQAGADVDAADN 348

Query: 432 NNESPLHFAARYG 444
              +PL  A R G
Sbjct: 349 RKITPLMAAFRKG 361



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 33/97 (34%), Positives = 50/97 (51%), Gaps = 1/97 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L +A   GH  +V  LL RGA + HRD  G  PL LAA +G+   +E+L    + +  
Sbjct: 49  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEA 108

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 109 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 145



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 68/313 (21%), Positives = 122/313 (38%), Gaps = 18/313 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL    +   
Sbjct: 49  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEA 108

Query: 109 LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
            +E+ +  P+ +A    +  V+++     +  N         T L  AA   +    KIL
Sbjct: 109 QSERTKDTPLSLACSGGRQEVVELLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 166

Query: 168 IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           +    +   +     G  P+  AA N  +  +++ L  G       E          N  
Sbjct: 167 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE-------TNRNTA 219

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 220 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 274

Query: 287 LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           + +  V   + T +  AA   H +    LI  G+ I+  +K+  +PL LAA+      V 
Sbjct: 275 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 334

Query: 345 TLIRLGADIQLKD 357
            L++ GAD+   D
Sbjct: 335 LLVQAGADVDAAD 347



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
           SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 123 SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 182

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +PL +A  N    A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 183 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA-- 240

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 241 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 289

Query: 200 VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           +    G  + C     R   I + + +GN PL  A +GG +  V+L +++GA +    + 
Sbjct: 290 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 349

Query: 256 LSTPVHLACAQGALDIVKLM 275
             TP+  A  +G + +V+ +
Sbjct: 350 KITPLMAAFRKGHVKVVRYL 369



 Score = 35.9 bits (79), Expect = 0.85
 Identities = 20/83 (24%), Positives = 40/83 (48%), Gaps = 1/83 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+   F  L +   + + VR+ +G T    A+   + +++  +     D++A DN 
Sbjct: 291 AADKGHYK-FCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 349

Query: 80  GNTPLHVAVENEALDAIEYLLQQ 102
             TPL  A     +  + YL+++
Sbjct: 350 KITPLMAAFRKGHVKVVRYLVKE 372



 Score = 35.5 bits (78), Expect = 1.1
 Identities = 25/117 (21%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A+ + +      +      ++ ++  GNTPL +A     LD ++ L+Q   +   
Sbjct: 286 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 345

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + +   P+  A     V V++   K      VNQ         + A I D ++  K
Sbjct: 346 ADNRKITPLMAAFRKGHVKVVRYLVK-----EVNQFPSDSECMRYIATITDKEMLKK 397


>AB014597-1|BAA31672.2| 2486|Homo sapiens KIAA0697 protein protein.
          Length = 2486

 Score =  102 bits (245), Expect = 7e-21
 Identities = 93/334 (27%), Positives = 152/334 (45%), Gaps = 24/334 (7%)

Query: 220  DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALDIVKLMFTM 278
            D +G  PL  A   G +  VE+ L +GA I  Q +    TP+ LAC+ G  ++V+L+   
Sbjct: 996  DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 1055

Query: 279  QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR--SPLLLAAS 336
               ++H      +V   TP+  AA   +  I+  L+N G++IN     +   SPL+LAA 
Sbjct: 1056 GANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1110

Query: 337  RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEK 396
                  V  L+ +G+DI  +   +RN    +    GR E  +              +  +
Sbjct: 1111 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN------VEHR 1164

Query: 397  DNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRFHTACQLLD 454
              TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +   C+LL 
Sbjct: 1165 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF-CELLI 1223

Query: 455  SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPLHLAAMSGY 513
              +G  I +  + +G TPL +A+  GH  VV LL+  GA +    N +  PL  A   G+
Sbjct: 1224 G-RGAHI-DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1281

Query: 514  TKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
             K +  L       ++Q   D     ++AT+ +K
Sbjct: 1282 VKVVRYLVKE----VNQFPSDSECMRYIATITDK 1311



 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 125/500 (25%), Positives = 203/500 (40%), Gaps = 34/500 (6%)

Query: 78  NAG---NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           NAG   N  L  A     ++A+  LL +    +   E+ ++ + +A       + QV   
Sbjct: 113 NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 172

Query: 135 YKSLFNVNQGGEHGR-TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
             +  NV   G  G  T+L  AA   H    K+L+    A+     + G   +  A    
Sbjct: 173 MHA--NVEDRGIKGDITSLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGG 229

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
               ++V L+ G          I  ++  G+ PL  A   G ++   L L +GA I+T  
Sbjct: 230 YVDVVKVLLESGAS--------IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 281

Query: 254 HDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
           ++   + + LAC +G L++V+ +      ++H      D +  T +  A M  H E+   
Sbjct: 282 NEFKESALTLACYKGHLEMVRFLLEAGADQEH----KTD-EMHTALMEACMDGHVEVARL 336

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ G+ +N       SPL LAA          LI  GA   L+++N      L+     
Sbjct: 337 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS--LEEVNDEGYTPLMEAARE 394

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
             E+  A           Q     + T  + L  A   G +   + LI+ GA I L    
Sbjct: 395 GHEEMVALLLGQGANINAQT----EETQETALTLACCGGFLEVADFLIKAGADIEL---G 447

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PL  AA+ G       LL +      ++ +   G T L  A   GHT V  +LL  G
Sbjct: 448 CSTPLMEAAQEGHLELVKYLLAAGAN---VHATTATGDTALTYACENGHTDVADVLLQAG 504

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A L H    GR PL  AA +G+  T++ L S  +++      + +T L LA      + +
Sbjct: 505 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 564

Query: 552 ALLLSMGCRLSYNNMDMSAI 571
            LLL+ G   ++   D S +
Sbjct: 565 ELLLAHGADPTHRLKDGSTM 584



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 80/274 (29%), Positives = 123/274 (44%), Gaps = 12/274 (4%)

Query: 296  TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
            T +  A    H E+V  L+  G+ I   DK+  +PL+LAA+      V  L+  GADI+ 
Sbjct: 968  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1027

Query: 356  KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
            +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++  
Sbjct: 1028 QSERTKDTPLSLACSGGRQEVVELLLARGANK---EHRNVSDYT---PLSLAASGGYVNI 1081

Query: 416  LENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            ++ L+  GA IN +  +    SPL  AA  G  HTA   L  D G+ I  + +    T L
Sbjct: 1082 IKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETNRNTAL 1139

Query: 474  HIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQI 531
             +A  +G T VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    +
Sbjct: 1140 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1199

Query: 532  DKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
                +T+L +A  +       LL+  G  +   N
Sbjct: 1200 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1233



 Score = 81.8 bits (193), Expect = 1e-14
 Identities = 103/442 (23%), Positives = 177/442 (40%), Gaps = 26/442 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T+   A+   +  I+  +  +  D+NA+ + GNT L  A     +D ++ LL+       
Sbjct: 187 TSLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 246

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
            NE    P+  A     V V ++  +  +  N +   E   +AL  A    H    + L+
Sbjct: 247 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLL 305

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
            +  A+ +   +  +  + EA  +       + L  G Q        +++  +    PL 
Sbjct: 306 -EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLT 356

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
            A  GG ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A   
Sbjct: 357 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG-QGANINAQTE 415

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
                 +T   C       E+ ++LI  G+DI   +    +PL+ AA       V  L+ 
Sbjct: 416 ETQETALTLACCGGFL---EVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLA 469

Query: 349 LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
            GA++          L     NG    D A    D   ++   L +E +  G +PL  A+
Sbjct: 470 AGANVHATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAA 522

Query: 409 REGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
           R GH+ +++ LI  GA +N    NN+  +   A  G      +LL +          DG 
Sbjct: 523 RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS 582

Query: 469 GLTPLHIASREGHTRVVHLLLN 490
             T L  A++ GHT VV  LL+
Sbjct: 583 --TMLIEAAKGGHTSVVCYLLD 602



 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 100/464 (21%), Positives = 182/464 (39%), Gaps = 28/464 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K +++  + AA  G+V   ++L L+  + +  +   G TA   A A    +++  +    
Sbjct: 183 KGDITSLMAAANGGHVK-IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 241

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVL 129
             +   +  G+TPL  A     ++    LL+     +   NE  ++ + +A     + ++
Sbjct: 242 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 301

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
           +   +  +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  A
Sbjct: 302 RFLLEAGA--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLA 358

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A         + +    +RG + E++    ++EG  PL  A   G  + V L L  GA I
Sbjct: 359 ACGGHVELAALLI----ERGASLEEV----NDEGYTPLMEAAREGHEEMVALLLGQGANI 410

Query: 250 STQQHDL-STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           + Q  +   T + LAC  G L++   +       +  C         TP+  AA   H E
Sbjct: 411 NAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--------STPLMEAAQEGHLE 462

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +V YL+  G++++       + L  A           L++ GAD++ +    R  L    
Sbjct: 463 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL---- 518

Query: 369 MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           M   R      + +    K    +     N   + L  A   GH+  +E L+  GA    
Sbjct: 519 MKAAR-AGHVCTVQFLISKG-ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTH 576

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           +  +  + L  AA+ G     C LLD           D   LTP
Sbjct: 577 RLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 620



 Score = 62.9 bits (146), Expect = 6e-09
 Identities = 77/305 (25%), Positives = 122/305 (40%), Gaps = 16/305 (5%)

Query: 220  DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
            ++  +  L  A  GG  + V+  L  GA I  +     TP+ LA   G + +V+++    
Sbjct: 963  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1022

Query: 280  PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               +       +  K TP+  A      E+V  L+  G++    +    +PL LAAS   
Sbjct: 1023 ADIE----AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 1078

Query: 340  WRTVHTLIRLGADIQLKDINSRNV--LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
               +  L+  GA+I  +  +   +  L L  MNG      A          +   +    
Sbjct: 1079 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG---HTAAVKLLLDMGSDINAQIETNR 1135

Query: 398  NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
            NT    L  A  +G    +  L+   A +  +     +PL  AA  G       LL  DK
Sbjct: 1136 NTA---LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL--DK 1190

Query: 458  GTFI-INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTK 515
            G  +          T L IA+ +GH +   LL+ RGA +  R+  G  PL LAA  G+  
Sbjct: 1191 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1250

Query: 516  TIELL 520
             ++LL
Sbjct: 1251 VVQLL 1255



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 73/313 (23%), Positives = 136/313 (43%), Gaps = 31/313 (9%)

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            ++    + G T L  AA   H    +IL+    D++A+ ++  +    P+  A       
Sbjct: 991  SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDT---PLSLACSGGRQE 1047

Query: 197  TIEVFLQWGEQRGCTREQM-ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
             +E+ L     RG  +E   +S Y      PL  A  GG +  +++ L +GA+I+++   
Sbjct: 1048 VVELLLA----RGANKEHRNVSDY-----TPLSLAASGGYVNIIKILLNAGAEINSRTGS 1098

Query: 256  LS--TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYL 313
                +P+ LA   G    VKL+  M            +  + T +  A      E+V+ L
Sbjct: 1099 KLGISPLMLAAMNGHTAAVKLLLDMGSDIN----AQIETNRNTALTLACFQGRTEVVSLL 1154

Query: 314  INEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDI-NSRNVLHLVVMNGG 372
            ++  +++    K   +PL+ AAS         L+  GAD+    + +SR+    +  + G
Sbjct: 1155 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1214

Query: 373  RLEDFAASCKDHCEKSL-LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
              +     C+    +   + + N+K NT   PL  A+  GH+  ++ L++ GA ++  +N
Sbjct: 1215 HYK----FCELLIGRGAHIDVRNKKGNT---PLWLAANGGHLDVVQLLVQAGADVDAADN 1267

Query: 432  NNESPLHFAARYG 444
               +PL  A R G
Sbjct: 1268 RKITPLMAAFRKG 1280



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 33/97 (34%), Positives = 50/97 (51%), Gaps = 1/97 (1%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
            T L +A   GH  +V  LL RGA + HRD  G  PL LAA +G+   +E+L    + +  
Sbjct: 968  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1027

Query: 530  QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
            Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 1028 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1064



 Score = 52.8 bits (121), Expect = 7e-06
 Identities = 68/313 (21%), Positives = 122/313 (38%), Gaps = 18/313 (5%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL    +   
Sbjct: 968  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1027

Query: 109  LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             +E+ +  P+ +A    +  V+++     +  N         T L  AA   +    KIL
Sbjct: 1028 QSERTKDTPLSLACSGGRQEVVELLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 1085

Query: 168  IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
            +    +   +     G  P+  AA N  +  +++ L  G       E          N  
Sbjct: 1086 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE-------TNRNTA 1138

Query: 227  LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
            L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 1139 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 1193

Query: 287  LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
            + +  V   + T +  AA   H +    LI  G+ I+  +K+  +PL LAA+      V 
Sbjct: 1194 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1253

Query: 345  TLIRLGADIQLKD 357
             L++ GAD+   D
Sbjct: 1254 LLVQAGADVDAAD 1266



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23   SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
            SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 1042 SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1101

Query: 81   NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             +PL +A  N    A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 1102 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKA-- 1159

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 1160 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 1208

Query: 200  VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +    G  + C     R   I + + +GN PL  A +GG +  V+L +++GA +    + 
Sbjct: 1209 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1268

Query: 256  LSTPVHLACAQGALDIVKLM 275
              TP+  A  +G + +V+ +
Sbjct: 1269 KITPLMAAFRKGHVKVVRYL 1288



 Score = 35.9 bits (79), Expect = 0.85
 Identities = 20/83 (24%), Positives = 40/83 (48%), Gaps = 1/83 (1%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA+ G+   F  L +   + + VR+ +G T    A+   + +++  +     D++A DN 
Sbjct: 1210 AADKGHYK-FCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1268

Query: 80   GNTPLHVAVENEALDAIEYLLQQ 102
              TPL  A     +  + YL+++
Sbjct: 1269 KITPLMAAFRKGHVKVVRYLVKE 1291



 Score = 35.5 bits (78), Expect = 1.1
 Identities = 25/117 (21%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A+ + +      +      ++ ++  GNTPL +A     LD ++ L+Q   +   
Sbjct: 1205 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1264

Query: 109  LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
             + +   P+  A     V V++   K      VNQ         + A I D ++  K
Sbjct: 1265 ADNRKITPLMAAFRKGHVKVVRYLVK-----EVNQFPSDSECMRYIATITDKEMLKK 1316


>AY070436-1|AAL65263.1|  968|Homo sapiens hypothetical protein
           protein.
          Length = 968

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
           R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 571 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 630

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
           +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 631 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 685

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 686 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 743

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
               +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 744 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 799

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
              C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 800 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 856

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
             A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 857 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 894



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 551 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 606

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
               Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 607 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 662

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
           +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 663 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 719

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 720 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 778

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
              + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 779 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 834

Query: 449 ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
              L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 835 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 872



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 17/335 (5%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQK 294
           I AV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +   
Sbjct: 494 IAAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 551

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
              + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+
Sbjct: 552 ALTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 609

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
            +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++ 
Sbjct: 610 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVN 663

Query: 415 SLENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
            ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T 
Sbjct: 664 IIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTA 721

Query: 473 LHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
           L +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    
Sbjct: 722 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 781

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +    +T+L +A  +       LL+  G  +   N
Sbjct: 782 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 816



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 63/218 (28%), Positives = 99/218 (45%), Gaps = 28/218 (12%)

Query: 400 GCS-PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS--- 455
           GCS PL  AS+EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +   
Sbjct: 9   GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 68

Query: 456 -----DKGTFI---------INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR--DH 499
                D  T +          +ES+G G TPL  A+R GH   V  L+++GA ++R   +
Sbjct: 69  LDKQEDMKTILEGIDPAKHQEHESEG-GRTPLMKAARAGHLCTVQFLISKGANVNRATAN 127

Query: 500 NGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGC 559
           N    + LA   G+   +ELL +  +    ++ KDG+T L  A      + ++ LL    
Sbjct: 128 NDHTVVSLACAGGHLAVVELLLAHGADPTHRL-KDGSTMLIEAAKGGHTNVVSYLLDYPN 186

Query: 560 R-LSYNNMDMSAI-----DYAIYYKFPEAALAMVTHEQ 591
             LS    D+S +     D +   + P   LAMV   Q
Sbjct: 187 NVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQ 224



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 551 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 610

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 611 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 647



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 551 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 610

Query: 109 LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
            +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 611 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 668

Query: 168 IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 669 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 721

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 722 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 776

Query: 287 LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 777 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 836

Query: 345 TLIRLGADIQLKD 357
            L++ GAD+   D
Sbjct: 837 LLVQAGADVDAAD 849



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
           SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 625 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 684

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 685 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 742

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 743 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 791

Query: 200 VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 792 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 851

Query: 256 LSTPVHLACAQGALDIVKLM 275
             TP+  A  +G + +V+ +
Sbjct: 852 KITPLMSAFRKGHVKVVQYL 871



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 793 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 851

Query: 80  GNTPLHVAVENEALDAIEYLLQQ 102
             TPL  A     +  ++YL+++
Sbjct: 852 KITPLMSAFRKGHVKVVQYLVKE 874



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 788 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 847

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 848 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 899


>AK074173-1|BAB84999.1| 1486|Homo sapiens FLJ00246 protein protein.
          Length = 1486

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212  REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
            R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 1110 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1169

Query: 271  IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
            +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 1170 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1224

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 1225 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 1282

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
                +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 1283 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1338

Query: 447  HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
               C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 1339 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1395

Query: 506  HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
              A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 1396 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 1433



 Score = 92.3 bits (219), Expect = 9e-18
 Identities = 133/567 (23%), Positives = 230/567 (40%), Gaps = 56/567 (9%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 225 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 284

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 285 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 341

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 342 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 393

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 394 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 448

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 449 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 508

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 509 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 558

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS--------DKGTFI 461
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +        D  T +
Sbjct: 559 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 618

Query: 462 I---------NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR--DHNGRNPLHLAAM 510
                     +ES+G G TPL  A+R GH   V  L+++GA ++R   +N    + LA  
Sbjct: 619 EGIDPAKHQEHESEG-GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 677

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR-LSYNNMDMS 569
            G+   +ELL +  +    ++ KDG+T L  A      + ++ LL      LS    D+S
Sbjct: 678 GGHLAVVELLLAHGADPTHRL-KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 736

Query: 570 AI-----DYAIYYKFPEAALAMVTHEQ 591
            +     D +   + P   LAMV   Q
Sbjct: 737 QLPPPSQDQSQVPRVPTHTLAMVVPPQ 763



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150  TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
            TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 1090 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 1145

Query: 210  CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 1146 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1201

Query: 270  DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
            +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 1202 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1258

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 1259 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 1317

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
               + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 1318 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1373

Query: 449  ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
               L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 1374 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 1411



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 17/335 (5%)

Query: 236  IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQK 294
            I AV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +   
Sbjct: 1033 IAAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 1090

Query: 295  MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
               + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+
Sbjct: 1091 ALTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1148

Query: 355  LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
             +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++ 
Sbjct: 1149 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVN 1202

Query: 415  SLENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
             ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T 
Sbjct: 1203 IIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTA 1260

Query: 473  LHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
            L +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    
Sbjct: 1261 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1320

Query: 531  IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
            +    +T+L +A  +       LL+  G  +   N
Sbjct: 1321 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1355



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
            T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 1090 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1149

Query: 530  QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
            Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 1150 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1186



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 1090 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1149

Query: 109  LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 1150 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 1207

Query: 168  IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
            +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 1208 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 1260

Query: 227  LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
            L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 1261 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 1315

Query: 287  LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
            + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 1316 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1375

Query: 345  TLIRLGADIQLKD 357
             L++ GAD+   D
Sbjct: 1376 LLVQAGADVDAAD 1388



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23   SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
            SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 1164 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1223

Query: 81   NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 1224 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 1281

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 1282 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 1330

Query: 200  VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 1331 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1390

Query: 256  LSTPVHLACAQGALDIVKLM 275
              TP+  A  +G + +V+ +
Sbjct: 1391 KITPLMSAFRKGHVKVVQYL 1410



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 1332 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1390

Query: 80   GNTPLHVAVENEALDAIEYLLQQ 102
              TPL  A     +  ++YL+++
Sbjct: 1391 KITPLMSAFRKGHVKVVQYLVKE 1413



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 1327 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1386

Query: 109  LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
             + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 1387 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 1438


>AK000295-1|BAA91063.1|  686|Homo sapiens protein ( Homo sapiens
           cDNA FLJ20288 fis, clone HEP04414. ).
          Length = 686

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
           R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 288 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 347

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
           +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 348 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 402

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 403 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 460

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
               +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 461 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 516

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
              C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 517 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 573

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
             A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 574 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 611



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 268 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 323

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
               Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 324 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 379

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
           +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 380 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 436

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 437 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 495

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
              + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 496 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 551

Query: 449 ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
              L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 552 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 589



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 89/334 (26%), Positives = 144/334 (43%), Gaps = 17/334 (5%)

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQKM 295
           KAV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +    
Sbjct: 212 KAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDVDAHTESNHDTA 269

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
             + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+ 
Sbjct: 270 LTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 327

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++  
Sbjct: 328 QSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVNI 381

Query: 416 LENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
           ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T L
Sbjct: 382 IKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTAL 439

Query: 474 HIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQI 531
            +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    +
Sbjct: 440 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 499

Query: 532 DKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
               +T+L +A  +       LL+  G  +   N
Sbjct: 500 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 533



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 268 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 327

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 328 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 364



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 268 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 327

Query: 109 LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
            +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 328 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 385

Query: 168 IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 386 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 438

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 439 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 493

Query: 287 LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 494 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 553

Query: 345 TLIRLGADIQLKD 357
            L++ GAD+   D
Sbjct: 554 LLVQAGADVDAAD 566



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 21/168 (12%)

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS--------DKG 458
           AS+EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +        D  
Sbjct: 3   ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 62

Query: 459 TFII---------NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR--DHNGRNPLHL 507
           T +          +ES+G G TPL  A+R GH   V  L+++GA ++R   +N    + L
Sbjct: 63  TILEGIDPAKHQEHESEG-GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 121

Query: 508 AAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           A   G+   +ELL +  +    ++ KDG+T L  A      + ++ LL
Sbjct: 122 ACAGGHLAVVELLLAHGADPTHRL-KDGSTMLIEAAKGGHTNVVSYLL 168



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
           SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 342 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 401

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 402 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 459

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 460 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 508

Query: 200 VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 509 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 568

Query: 256 LSTPVHLACAQGALDIVKLM 275
             TP+  A  +G + +V+ +
Sbjct: 569 KITPLMSAFRKGHVKVVQYL 588



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 47/190 (24%), Positives = 79/190 (41%), Gaps = 23/190 (12%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           A+   H E+V YL+  G++++       + L  A           L++ GAD+  K  + 
Sbjct: 3   ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDM 61

Query: 361 RNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLI 420
           + +L  +           A  ++H           +   G +PL  A+R GH+ +++ LI
Sbjct: 62  KTILEGID---------PAKHQEH-----------ESEGGRTPLMKAARAGHLCTVQFLI 101

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
             GA +N    NN+  +   A  G      +LL +          DG   T L  A++ G
Sbjct: 102 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS--TMLIEAAKGG 159

Query: 481 HTRVVHLLLN 490
           HT VV  LL+
Sbjct: 160 HTNVVSYLLD 169



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 33/101 (32%), Positives = 46/101 (45%), Gaps = 3/101 (2%)

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
           ++    +PL  AAR G   T  Q L S KG  +   +     T + +A   GH  VV LL
Sbjct: 77  ESEGGRTPLMKAARAGHLCTV-QFLIS-KGANVNRATANNDHTVVSLACAGGHLAVVELL 134

Query: 489 LNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           L  GA   HR  +G   L  AA  G+T  +  L    +++L
Sbjct: 135 LAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVL 175



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 510 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 568

Query: 80  GNTPLHVAVENEALDAIEYLLQQ 102
             TPL  A     +  ++YL+++
Sbjct: 569 KITPLMSAFRKGHVKVVQYLVKE 591



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 505 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 564

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 565 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 616


>AF521883-1|AAO14944.1| 2617|Homo sapiens multiple ankyrin repeats
            single KH domain protein isoform 2 protein.
          Length = 2617

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212  REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
            R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 1077 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 271  IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
            +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 1137 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 1249

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
                +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 1250 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305

Query: 447  HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
               C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 1306 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 506  HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
              A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 1363 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 1400



 Score = 88.6 bits (210), Expect = 1e-16
 Identities = 93/355 (26%), Positives = 150/355 (42%), Gaps = 19/355 (5%)

Query: 219 YDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKLMFT 277
           ++  G+ PL  A   G ++   + L  GA I+T  ++   + + LAC +G LD+V+ +  
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 278 MQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASR 337
               ++H      D +  T +  A M  H E+   L++ G+ +N       SPL LAA  
Sbjct: 394 AGADQEH----KTD-EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448

Query: 338 AGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
                   LI  GA+  L+++N      L+       E+  A           Q     +
Sbjct: 449 GHVELAALLIERGAN--LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT----E 502

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
            T  + L  A   G     + LI+ GA I L      +PL  A++ G       LL S  
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGA 559

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKT 516
               ++ +   G T L  A   GHT V  +LL  GA L H    GR PL  AA +G+  T
Sbjct: 560 N---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 517 IELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           ++ L S  +++      + +T + LA      + + LLL+ G   ++   D S +
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150  TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
            TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 1057 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 1112

Query: 210  CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 1113 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 270  DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
            +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 1284

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
               + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 1285 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 449  ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
               L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 1341 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 82.2 bits (194), Expect = 1e-14
 Identities = 106/438 (24%), Positives = 177/438 (40%), Gaps = 28/438 (6%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           AS+    +I+  +  +  D+N++   GNT L  A     +D ++ LL +       NE  
Sbjct: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLD 172
             P+  A     V V +V   + +  N +   E   +AL  A    H D+   +L    D
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 173 AEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVH 232
            E K   +  +  + EA  +       + L  G Q        +++  +    PL  A  
Sbjct: 398 QEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAAC 447

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A       
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA-QGANINAQTEETQE 506

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T + C   F   E+ ++LI  G+DI   +    +PL+ A+       V  L+  GA+
Sbjct: 507 TALT-LACCGGFS--EVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           +          L     NG    D A    D   ++   L +E +  G +PL  A+R GH
Sbjct: 561 VHATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAARAGH 613

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           + +++ LI  GA +N    NN+  +   A  G      +LL +          DG   T 
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS--TM 671

Query: 473 LHIASREGHTRVVHLLLN 490
           L  A++ GHT VV  LL+
Sbjct: 672 LIEAAKGGHTNVVSYLLD 689



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 17/335 (5%)

Query: 236  IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQK 294
            I AV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +   
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 1057

Query: 295  MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
               + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+
Sbjct: 1058 ALTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 355  LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
             +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++ 
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVN 1169

Query: 415  SLENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
             ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T 
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTA 1227

Query: 473  LHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
            L +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287

Query: 531  IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
            +    +T+L +A  +       LL+  G  +   N
Sbjct: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 77/353 (21%), Positives = 144/353 (40%), Gaps = 19/353 (5%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA-GN 81
           +G   D +++ L+E + +   +  G T   +A++  +  +   + ++   +N   N    
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           + L +A     LD + +LL+   +     ++    +  A     V V ++     S   V
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD--SGAQV 431

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           N   +   + L  AA   H   A +LI +  A  ++  + GY P+ EAA+      + + 
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G       E+            L  A  GG  +  +  +++GA I       STP+ 
Sbjct: 491 LAQGANINAQTEET-------QETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLM 540

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
            A  +G L++VK +        HA   + D    T +  A    H ++ + L+  G+D+ 
Sbjct: 541 EASQEGHLELVKYLLA-SGANVHATTATGD----TALTYACENGHTDVADVLLQAGADLE 595

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
              +  R+PL+ AA      TV  LI  GA++     N+ + +  +   GG L
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648



 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 100/459 (21%), Positives = 180/459 (39%), Gaps = 31/459 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL- 374
            G++++       + L  A           L++ GAD++ +    R  L +     G L 
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL-MKAARAGHLC 615

Query: 375 -EDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
              F  S   +  ++        D+T  S    A   GH+  +E L+  GA    +  + 
Sbjct: 616 TVQFLISKGANVNRATA----NNDHTVVS---LACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
            + L  AA+ G  +    LLD       +  +D   L P
Sbjct: 669 STMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPP 707



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
            T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 530  QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
            Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 109  LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 168  IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
            +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 1227

Query: 227  LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
            L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 1282

Query: 287  LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
            + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342

Query: 345  TLIRLGADIQLKD 357
             L++ GAD+   D
Sbjct: 1343 LLVQAGADVDAAD 1355



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23   SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
            SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190

Query: 81   NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 1248

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 1297

Query: 200  VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 256  LSTPVHLACAQGALDIVKLM 275
              TP+  A  +G + +V+ +
Sbjct: 1358 KITPLMSAFRKGHVKVVQYL 1377



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 1299 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 80   GNTPLHVAVENEALDAIEYLLQQ 102
              TPL  A     +  ++YL+++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 109  LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
             + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 1405


>AF521882-1|AAO14943.1| 2542|Homo sapiens multiple ankyrin repeats
            single KH domain protein isoform 1 protein.
          Length = 2542

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212  REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
            R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 1077 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136

Query: 271  IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
            +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 1137 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 1249

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
                +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 1250 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305

Query: 447  HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
               C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 1306 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 506  HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
              A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 1363 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 1400



 Score = 88.6 bits (210), Expect = 1e-16
 Identities = 93/355 (26%), Positives = 150/355 (42%), Gaps = 19/355 (5%)

Query: 219 YDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKLMFT 277
           ++  G+ PL  A   G ++   + L  GA I+T  ++   + + LAC +G LD+V+ +  
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 278 MQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASR 337
               ++H      D +  T +  A M  H E+   L++ G+ +N       SPL LAA  
Sbjct: 394 AGADQEH----KTD-EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448

Query: 338 AGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKD 397
                   LI  GA+  L+++N      L+       E+  A           Q     +
Sbjct: 449 GHVELAALLIERGAN--LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT----E 502

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
            T  + L  A   G     + LI+ GA I L      +PL  A++ G       LL S  
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGA 559

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKT 516
               ++ +   G T L  A   GHT V  +LL  GA L H    GR PL  AA +G+  T
Sbjct: 560 N---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 517 IELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           ++ L S  +++      + +T + LA      + + LLL+ G   ++   D S +
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150  TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
            TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 1057 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 1112

Query: 210  CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 1113 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168

Query: 270  DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
            +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 1169 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
            + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 1284

Query: 389  LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
               + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 1285 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 449  ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
               L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 1341 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score = 82.2 bits (194), Expect = 1e-14
 Identities = 106/438 (24%), Positives = 177/438 (40%), Gaps = 28/438 (6%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           AS+    +I+  +  +  D+N++   GNT L  A     +D ++ LL +       NE  
Sbjct: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLD 172
             P+  A     V V +V   + +  N +   E   +AL  A    H D+   +L    D
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 173 AEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVH 232
            E K   +  +  + EA  +       + L  G Q        +++  +    PL  A  
Sbjct: 398 QEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAAC 447

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A       
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA-QGANINAQTEETQE 506

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T + C   F   E+ ++LI  G+DI   +    +PL+ A+       V  L+  GA+
Sbjct: 507 TALT-LACCGGFS--EVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           +          L     NG    D A    D   ++   L +E +  G +PL  A+R GH
Sbjct: 561 VHATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAARAGH 613

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           + +++ LI  GA +N    NN+  +   A  G      +LL +          DG   T 
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS--TM 671

Query: 473 LHIASREGHTRVVHLLLN 490
           L  A++ GHT VV  LL+
Sbjct: 672 LIEAAKGGHTNVVSYLLD 689



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 17/335 (5%)

Query: 236  IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQK 294
            I AV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +   
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 1057

Query: 295  MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
               + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+
Sbjct: 1058 ALTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 355  LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
             +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++ 
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVN 1169

Query: 415  SLENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
             ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T 
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTA 1227

Query: 473  LHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
            L +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287

Query: 531  IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
            +    +T+L +A  +       LL+  G  +   N
Sbjct: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 77/353 (21%), Positives = 144/353 (40%), Gaps = 19/353 (5%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA-GN 81
           +G   D +++ L+E + +   +  G T   +A++  +  +   + ++   +N   N    
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           + L +A     LD + +LL+   +     ++    +  A     V V ++     S   V
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD--SGAQV 431

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           N   +   + L  AA   H   A +LI +  A  ++  + GY P+ EAA+      + + 
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G       E+            L  A  GG  +  +  +++GA I       STP+ 
Sbjct: 491 LAQGANINAQTEET-------QETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLM 540

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
            A  +G L++VK +        HA   + D    T +  A    H ++ + L+  G+D+ 
Sbjct: 541 EASQEGHLELVKYLLA-SGANVHATTATGD----TALTYACENGHTDVADVLLQAGADLE 595

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL 374
              +  R+PL+ AA      TV  LI  GA++     N+ + +  +   GG L
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648



 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 100/459 (21%), Positives = 180/459 (39%), Gaps = 31/459 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRL- 374
            G++++       + L  A           L++ GAD++ +    R  L +     G L 
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL-MKAARAGHLC 615

Query: 375 -EDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNN 433
              F  S   +  ++        D+T  S    A   GH+  +E L+  GA    +  + 
Sbjct: 616 TVQFLISKGANVNRATA----NNDHTVVS---LACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
            + L  AA+ G  +    LLD       +  +D   L P
Sbjct: 669 STMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPP 707



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
            T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 530  QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
            Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 109  LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 168  IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
            +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 1227

Query: 227  LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
            L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 1282

Query: 287  LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
            + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342

Query: 345  TLIRLGADIQLKD 357
             L++ GAD+   D
Sbjct: 1343 LLVQAGADVDAAD 1355



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23   SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
            SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190

Query: 81   NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 1248

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 1297

Query: 200  VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
            +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 256  LSTPVHLACAQGALDIVKLM 275
              TP+  A  +G + +V+ +
Sbjct: 1358 KITPLMSAFRKGHVKVVQYL 1377



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 1299 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 80   GNTPLHVAVENEALDAIEYLLQQ 102
              TPL  A     +  ++YL+++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49   TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
            TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 109  LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
             + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 1405


>AF217646-1|AAG41779.1|  532|Homo sapiens hypothetical protein
           protein.
          Length = 532

 Score =  100 bits (239), Expect = 4e-20
 Identities = 95/342 (27%), Positives = 153/342 (44%), Gaps = 24/342 (7%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQ-QHDLSTPVHLACAQGALD 270
           R+  I   D +G  PL  A   G +  VE+ L  G  I  Q +    TP+ LAC+ G  +
Sbjct: 154 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 213

Query: 271 IVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR-- 328
           +V L+      ++H      +V   TP+  AA   +  I+  L+N G++IN     +   
Sbjct: 214 VVDLLLARGANKEHR-----NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 268

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           SPL+LAA       V  L+ +G+DI  +   +RN    +    GR E  +          
Sbjct: 269 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN-- 326

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN--NNNESPLHFAARYGRF 446
               +  +  TG +PL  A+  G+      L+  GA +N     ++ ++ L  AA  G +
Sbjct: 327 ----VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 382

Query: 447 HTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGR-NPL 505
              C+LL   +G  I +  + +G TPL +AS  GH  VV LL+  GA +    N +  PL
Sbjct: 383 KF-CELL-IHRGAHI-DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 439

Query: 506 HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
             A   G+ K ++ L       ++Q   D     ++AT+ +K
Sbjct: 440 MSAFRKGHVKVVQYLVKE----VNQFPSDIECMRYIATITDK 477



 Score = 87.0 bits (206), Expect = 3e-16
 Identities = 87/341 (25%), Positives = 147/341 (43%), Gaps = 20/341 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           TAL  A    H+    +LI   DA+ +     G+ P+  AA       +E+ L  G   G
Sbjct: 134 TALTLACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG---G 189

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
               Q     +   + PL  A  GG  + V+L L  GA    +     TP+ LA + G +
Sbjct: 190 DIEAQS----ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 245

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP-LDKERR 328
           +I+K++     +      +   +   +P+  AAM  H   V  L++ GSDIN  ++  R 
Sbjct: 246 NIIKILLNAGAEINSRTGSKLGI---SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 302

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
           + L LA  +     V  L+   A+++ +       L +   +GG  E          + +
Sbjct: 303 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-MEAASGGYAEVGRVLLDKGADVN 361

Query: 389 LLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHT 448
              + + +D      L  A+ +GH +  E LI  GA I+++N    +PL  A+  G F  
Sbjct: 362 APPVPSSRDTA----LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 417

Query: 449 ACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
              L+ +      ++ +D   +TPL  A R+GH +VV  L+
Sbjct: 418 VQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 455



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 89/335 (26%), Positives = 144/335 (42%), Gaps = 17/335 (5%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV-KLMFTMQPKEKHACLTSCDVQK 294
           I AV   + +G+  S+Q  +  TP   +C+Q   ++  + M  + P       T  +   
Sbjct: 77  IAAVSTRVPTGSNSSSQTTECLTPE--SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 134

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
              + CA    H E+V+ LI   + I   DK+  +PL+LAA+      V  L+  G DI+
Sbjct: 135 ALTLACAG--GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 192

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
            +   +++    +  +GGR E           K   +  N  D T   PL  A+  G++ 
Sbjct: 193 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK---EHRNVSDYT---PLSLAASGGYVN 246

Query: 415 SLENLIRLGACINLKNNN--NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
            ++ L+  GA IN +  +    SPL  AA  G  H     L  D G+ I  + +    T 
Sbjct: 247 IIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HVPAVKLLLDMGSDINAQIETNRNTA 304

Query: 473 LHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHL-LDQ 530
           L +A  +G   VV LLL+R A + HR   G  PL  AA  GY +   +L    + +    
Sbjct: 305 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 364

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +    +T+L +A  +       LL+  G  +   N
Sbjct: 365 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 399



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L +A   GH  +V +L+ R A + HRD  G  PL LAA +G+   +E+L      +  
Sbjct: 134 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 193

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           Q ++  +T L LA    +   + LLL+ G    + N+
Sbjct: 194 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 230



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A A  +  ++  +      +  +D  G TPL +A     +  +E LL +  +   
Sbjct: 134 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 193

Query: 109 LNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
            +E+ +  P+ +A    +  V+ +     +  N         T L  AA   +    KIL
Sbjct: 194 QSERTKDTPLSLACSGGRQEVVDLLLARGA--NKEHRNVSDYTPLSLAASGGYVNIIKIL 251

Query: 168 IT-DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVP 226
           +    +   +     G  P+  AA N     +++ L  G       E          N  
Sbjct: 252 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE-------TNRNTA 304

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A   G  + V L L   A +  +     TP+  A + G  ++ +++      +K A 
Sbjct: 305 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL-----DKGAD 359

Query: 287 LTSCDV--QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           + +  V   + T +  AA   H +    LI+ G+ I+  +K+  +PL LA++   +  V 
Sbjct: 360 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 419

Query: 345 TLIRLGADIQLKD 357
            L++ GAD+   D
Sbjct: 420 LLVQAGADVDAAD 432



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 55/260 (21%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 23  SGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA--G 80
           SG   + + L L+  +    R+    T    A++    NI+  + N   ++N++  +  G
Sbjct: 208 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 267

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +PL +A  N  + A++ LL    + +  +       + +A    +  V+ +    K+  
Sbjct: 268 ISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA-- 325

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NV    + G T L  AA   +    ++L+ D  A+   P      P+  +   A    + 
Sbjct: 326 NVEHRAKTGLTPLMEAASGGYAEVGRVLL-DKGADVNAP------PVPSSRDTA----LT 374

Query: 200 VFLQWGEQRGCT----REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           +    G  + C     R   I + + +GN PL  A +GG    V+L +++GA +    + 
Sbjct: 375 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 434

Query: 256 LSTPVHLACAQGALDIVKLM 275
             TP+  A  +G + +V+ +
Sbjct: 435 KITPLMSAFRKGHVKVVQYL 454



 Score = 36.3 bits (80), Expect = 0.65
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+   F  L +   + + VR+ +G T    AS   + +++  +     D++A DN 
Sbjct: 376 AADKGHYK-FCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 434

Query: 80  GNTPLHVAVENEALDAIEYLLQQ 102
             TPL  A     +  ++YL+++
Sbjct: 435 KITPLMSAFRKGHVKVVQYLVKE 457



 Score = 34.3 bits (75), Expect = 2.6
 Identities = 26/117 (22%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           TA   A+ + +      + +    ++ ++  GNTPL +A      D ++ L+Q   +   
Sbjct: 371 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 430

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            + +   P+  A     V V+Q   K      VNQ         + A I D +L  K
Sbjct: 431 ADNRKITPLMSAFRKGHVKVVQYLVK-----EVNQFPSDIECMRYIATITDKELLKK 482


>DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protein
           kinase 1 protein.
          Length = 1430

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 483

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 484 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 600 NCNLDISN 607



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 502

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 561 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 613 PLHLAANNGILDVVRYLCLM 632



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 494

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 551

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 610

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMG 633



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 515

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 568

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 629 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543


>BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protein
           kinase 1 protein.
          Length = 1430

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 483

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 484 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 600 NCNLDISN 607



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 502

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 561 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 613 PLHLAANNGILDVVRYLCLM 632



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 494

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 551

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 610

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMG 633



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 515

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 568

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 629 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543


>AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protein
           kinase 1 protein.
          Length = 1455

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 483

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 484 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 600 NCNLDISN 607



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 502

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 561 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 613 PLHLAANNGILDVVRYLCLM 632



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 494

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 551

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 610

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMG 633



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 515

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 568

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 629 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543


>AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protein
           kinase 1 protein.
          Length = 1455

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 483

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 484 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 600 NCNLDISN 607



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 502

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 561 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 613 PLHLAANNGILDVVRYLCLM 632



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 494

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 551

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 610

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMG 633



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 515

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 568

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 629 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543


>AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protein
           kinase 1 protein.
          Length = 1455

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 483

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 484 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 600 NCNLDISN 607



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 502

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 561 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 613 PLHLAANNGILDVVRYLCLM 632



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 494

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 551

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 610

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMG 633



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 515

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 568

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 629 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543


>AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein
           DKFZp781I035 variant protein.
          Length = 1433

 Score =   99 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 12/248 (4%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 374 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 432

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLH 438
              ++ C       L+ KD +G   LH A+R GH    + L   G+  N+++   E+PLH
Sbjct: 433 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLH 486

Query: 439 FAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR- 497
            AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+  
Sbjct: 487 CAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 543

Query: 498 DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSM 557
           D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L   
Sbjct: 544 DKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 602

Query: 558 GCRLSYNN 565
            C L  +N
Sbjct: 603 NCNLDISN 610



 Score = 83.8 bits (198), Expect = 3e-15
 Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 14/260 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 389 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 447

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G   LHVA      D  + L       ++ +++ + P+H A      SV +  A  ++  
Sbjct: 448 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK--ALCEAGC 505

Query: 140 NVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      I
Sbjct: 506 NVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEVI 563

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L     +GC     +   D  GN PLH A   G++  V     +   +        T
Sbjct: 564 KTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 615

Query: 259 PVHLACAQGALDIVKLMFTM 278
           P+HLA   G LD+V+ +  M
Sbjct: 616 PLHLAANNGILDVVRYLCLM 635



 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 74/263 (28%), Positives = 115/263 (43%), Gaps = 12/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 385 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 444

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +     C      S     N +D    +PLH A+  G+    
Sbjct: 445 DKSGEMALH-VAARYGHADVAQLLC------SFGSNPNIQDKEEETPLHCAAWHGYYSVA 497

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 498 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 554

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 555 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 613

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 614 RTPLHLAANNGILDVVRYLCLMG 636



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 15/286 (5%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 404 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 463

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            +L+ +             D ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 464 AQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 518

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 519 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 571

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 572 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 631

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 632 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 674



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 375 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 433

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L  +K    + +  GE    LH+A+R GH  V  LL + G+  + +D     PLH AA  
Sbjct: 434 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 491

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 492 GYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 546


>AB033081-1|BAA86569.2| 1232|Homo sapiens KIAA1255 protein protein.
          Length = 1232

 Score = 97.9 bits (233), Expect = 2e-19
 Identities = 124/525 (23%), Positives = 207/525 (39%), Gaps = 38/525 (7%)

Query: 61   NILHFINNYA--GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH 118
            N LH  NN     D + KD+   T L +A+          LL      +      Q  +H
Sbjct: 631  NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLH 690

Query: 119  MATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKP 178
            MA +           ++++  NV    + G TAL  A  +   L    + T   A+   P
Sbjct: 691  MAIQRQDSKSALFLLEHQADINVRT--QDGETALQLAIRNQLPLVVDAICTR-GADMSVP 747

Query: 179  CNNGYYPIHEAAKNASSRTIEVFLQ-------WGEQRGCTREQMISLYDNEGNVPLHSAV 231
               G  P+  A  N         ++       WG   G   + ++    +E N P    +
Sbjct: 748  DEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFL 807

Query: 232  --HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
               G D+ +      +G     +  D  TP+HLA + G  + V+ +      E  A + +
Sbjct: 808  IRSGCDVNSPRQPGANGEG-EEEARDGQTPLHLAASWGLEETVQCLL-----EFGANVNA 861

Query: 290  CDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVHTLIR 348
             D +  TPIH A    H  I+  L++     +N  D++  +P   A +    ++   +++
Sbjct: 862  QDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK 921

Query: 349  L--GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
               GA  Q+ D   RN LH+ V N   +E        H   +       +D +  +PLH 
Sbjct: 922  RESGAAEQV-DNKGRNFLHVAVQNSD-IESVLFLISVHANVNS----RVQDASKLTPLHL 975

Query: 407  ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
            A + G    + NL+  GA +N    + ++ LH AA+     T C +L  +   F   + +
Sbjct: 976  AVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQD-LPTICSVLLENGVDFAAVDEN 1034

Query: 467  GEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAAMSGYTKTIEL----L 520
            G     LH+A   G    + +LL    +     N  G++PLH+    G      +    L
Sbjct: 1035 GNNA--LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFL 1092

Query: 521  HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
              +  + LD+ D DG+T L LA M+   +    ++  G RL  NN
Sbjct: 1093 ECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNN 1137



 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 102/472 (21%), Positives = 182/472 (38%), Gaps = 36/472 (7%)

Query: 47   GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
            G+T  H A  R ++    F+  +  D+N +   G T L +A+ N+    ++ +  +  + 
Sbjct: 685  GQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADM 744

Query: 107  SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHG--RTALHFAAIHDHDLCA 164
            SV +EK   P+ +A   N   +     ++         G  G  +T LH A   +++  A
Sbjct: 745  SVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTA 804

Query: 165  KILITD-----------LDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTRE 213
              LI              + E ++   +G  P+H AA      T++  L++G        
Sbjct: 805  CFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGAN------ 858

Query: 214  QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
              ++  D EG  P+H A+       ++L L S   I     D       ACA    +   
Sbjct: 859  --VNAQDAEGRTPIHVAISSQHGVIIQL-LVSHPDIHLNVRDRQGLTPFACAMTFKNNKS 915

Query: 274  LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--LDKERRSPL 331
                +  K +       D +    +H A      E V +LI+  +++N    D  + +PL
Sbjct: 916  AEAIL--KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPL 973

Query: 332  LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
             LA        V  L+  GA +     + +  LHL        +D    C    E  +  
Sbjct: 974  HLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQ-----QDLPTICSVLLENGV-- 1026

Query: 392  LLNEKDNTGCSPLHYASREGHIRSLENLI-RLGACINLKNNNNESPLHFAARYGRFHTAC 450
                 D  G + LH A   G + ++  L+          N   +SPLH   +YG+ + A 
Sbjct: 1027 DFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAA 1086

Query: 451  --QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN 500
               L       + +++ D +G T L +A  +G+  +   ++  GA L  ++N
Sbjct: 1087 IFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNN 1138



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 127/567 (22%), Positives = 217/567 (38%), Gaps = 58/567 (10%)

Query: 42  VRDGRGRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLL 100
           ++D +GRT  H +    N  +    +     DL  KD+ G+T L +AV++  + +     
Sbjct: 425 MQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSS----- 479

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
               + SV N     P+   T  ++ S      +  S  +       G   L  AA   +
Sbjct: 480 ----DQSV-NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTAT-GNCLLQRAAGAGN 533

Query: 161 DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYD 220
           +  A  L T+  A        G  P+H A ++  +      LQ G       E+ + L  
Sbjct: 534 EAAALFLATN-GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPK 592

Query: 221 NEGNV-----------PLHSAV--HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
              ++           PLH A+  +  D+ +V L  ++ A  +T    +     L  ++ 
Sbjct: 593 EAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRD 652

Query: 268 ALDIVKLMFT------MQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
              +   ++T       Q     A +        T +H A      +   +L+   +DIN
Sbjct: 653 QTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADIN 712

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASC 381
              ++  + L LA        V  +   GAD+ + D      L L + N   LED A++ 
Sbjct: 713 VRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANN--LEDIASTL 770

Query: 382 KDH-CEKSLLQLLNEKDNTGC--SPLHYASREGHIRSLENLIRLGACINLKNN------- 431
             H C+ +           GC  + LH A  E +  +   LIR G  +N           
Sbjct: 771 VRHGCDATCWG----PGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEG 826

Query: 432 -----NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVH 486
                + ++PLH AA +G   T   LL+       +N  D EG TP+H+A    H  ++ 
Sbjct: 827 EEEARDGQTPLHLAASWGLEETVQCLLEFGAN---VNAQDAEGRTPIHVAISSQHGVIIQ 883

Query: 487 LLLNRGAL-LH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
           LL++   + L+ RD  G  P   A      K+ E +    S   +Q+D  G   LH+A  
Sbjct: 884 LLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQ 943

Query: 545 ENKPSSIALLLSMGCRLSYNNMDMSAI 571
            +   S+  L+S+   ++    D S +
Sbjct: 944 NSDIESVLFLISVHANVNSRVQDASKL 970



 Score = 68.5 bits (160), Expect = 1e-10
 Identities = 88/354 (24%), Positives = 138/354 (38%), Gaps = 28/354 (7%)

Query: 34   LSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEAL 93
            L   + + VR   G TA   A       ++  I     D++  D  GN PL +A+ N   
Sbjct: 705  LEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLE 764

Query: 94   DAIEYLLQQHVETSVLNE---KC-QAPIHMATELNKVSVLQVFAKYKSLFN------VNQ 143
            D    L++   + +        C Q  +H A + N         +     N       N 
Sbjct: 765  DIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANG 824

Query: 144  GGEH----GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             GE     G+T LH AA    +   + L+ +  A        G  PIH A  +     I+
Sbjct: 825  EGEEEARDGQTPLHLAASWGLEETVQCLL-EFGANVNAQDAEGRTPIHVAISSQHGVIIQ 883

Query: 200  VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
            + +   +         +++ D +G  P   A+   + K+ E  L+  +  + +Q D    
Sbjct: 884  LLVSHPDIH-------LNVRDRQGLTPFACAMTFKNNKSAEAILKRESG-AAEQVDNKGR 935

Query: 260  VHLACAQGALDIVKLMFTMQPKEKHACLTS--CDVQKMTPIHCAAMFDHPEIVNYLINEG 317
              L  A    DI  ++F +     HA + S   D  K+TP+H A       IV  L+  G
Sbjct: 936  NFLHVAVQNSDIESVLFLI---SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAG 992

Query: 318  SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            + +N L K R++ L LAA +        L+  G D    D N  N LHL VM+G
Sbjct: 993  AKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 1046



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 96/416 (23%), Positives = 160/416 (38%), Gaps = 64/416 (15%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGA----LD 270
           + + D  G   LH  +  GD+ A    +++GA ++        TP+HL     +     D
Sbjct: 345 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 404

Query: 271 IVKLMFTMQPK--EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR 328
           ++  M  +     +  A     D +  TP+H + M  +  + + L+        LD E +
Sbjct: 405 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ----CKQLDLELK 460

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKS 388
                  S A W  V   I + +D  +          + V+NG   ++ + + +      
Sbjct: 461 DH---EGSTALWLAVQH-ITVSSDQSVNPFED-----VPVVNGTSFDENSFAAR------ 505

Query: 389 LLQLLNEKDN----TGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
           L+Q  +  D     TG   L  A+  G+  +   L   GA +N +N   E+PLH A R+G
Sbjct: 506 LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 565

Query: 445 RFHTACQLLDSDKGTFIINE---------------SDGEGL-TPLHIASREGHTRVVHLL 488
             +   +LL       +  E               +D   L TPLH+A    H  VV ++
Sbjct: 566 LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 625

Query: 489 LNRGA-LLH-------------RDHNGRNPLHLAAMSG-YTKTIELLHSVHSHLLDQIDK 533
           L + A  LH             +D   +  L LA  +G +T   +LL S     ++    
Sbjct: 626 LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGS--GAAINDTMS 683

Query: 534 DGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEAALAMVT 588
           DG T LH+A       S   LL     ++    D  +A+  AI  + P    A+ T
Sbjct: 684 DGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICT 739



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 46/170 (27%), Positives = 72/170 (42%), Gaps = 14/170 (8%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           LNE D+ G   L  A           L+   A +++ + +  S LH   + G    A  L
Sbjct: 312 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 371

Query: 453 LDSDKGTFIINESDGEGLTPLHIA---SREGHT--------RVVHLLLNRGALLH-RDHN 500
           + +  G F+   + G   TPLH+    S + H+        ++   LL  GA  + +D  
Sbjct: 372 IKN--GAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSK 429

Query: 501 GRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GR PLH++ M+G       L       L+  D +G+T+L LA      SS
Sbjct: 430 GRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSS 479


>D86982-1|BAA13218.1| 1180|Homo sapiens KIAA0229 protein.
          Length = 1180

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 118 NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 176

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 177 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 231

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 232 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 286

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 287 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 345

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 346 ALIEDH 351



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 119 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 178

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 179 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 238

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 239 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 297

Query: 572 DYAIYY 577
             A  +
Sbjct: 298 HEAALF 303



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 116 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 172

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 173 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 231

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 232 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 288

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 289 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 338



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 118 NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 177

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 178 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 235

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 236 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 286

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 287 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 337



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 123 DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 182

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 183 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 240

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 241 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 289

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 290 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 324



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 186 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 245

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 246 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 302

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 303 FGKTDVVQILL 313



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 202 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 260

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 261 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 317

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 318 DVNIKDNHGLTAL 330


>BC132832-1|AAI32833.1| 1134|Homo sapiens ankyrin repeat and sterile
           alpha motif domain containing 1A protein.
          Length = 1134

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 130

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 131 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 241 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 299

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 300 ALIEDH 305



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 251

Query: 572 DYAIYY 577
             A  +
Sbjct: 252 HEAALF 257



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 126

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 127 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 242

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 243 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 292



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 189

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 190 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 291



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 136

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 194

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 195 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 243

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 244 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 278



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 256

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 257 FGKTDVVQILL 267



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 156 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 215 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 271

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 272 DVNIKDNHGLTAL 284


>BC022396-1|AAH22396.1|  472|Homo sapiens Unknown (protein for
           IMAGE:4618556) protein.
          Length = 472

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 130

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 131 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 241 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 299

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 300 ALIEDH 305



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 251

Query: 572 DYAIYY 577
             A  +
Sbjct: 252 HEAALF 257



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 126

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 127 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 242

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 243 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 292



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 189

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 190 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 291



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 136

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 194

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 195 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 243

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 244 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 278



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 256

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 257 FGKTDVVQILL 267



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 156 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 215 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 271

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 272 DVNIKDNHGLTAL 284


>AL591002-1|CAI15138.1| 1134|Homo sapiens ankyrin repeat and sterile
           alpha motif domain containing 1A protein.
          Length = 1134

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 130

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 131 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 241 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 299

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 300 ALIEDH 305



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 251

Query: 572 DYAIYY 577
             A  +
Sbjct: 252 HEAALF 257



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 126

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 127 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 242

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 243 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 292



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 189

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 190 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 291



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 136

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 194

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 195 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 243

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 244 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 278



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 256

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 257 FGKTDVVQILL 267



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 156 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 215 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 271

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 272 DVNIKDNHGLTAL 284


>AL138721-1|CAI12437.1| 1134|Homo sapiens ankyrin repeat and sterile
           alpha motif domain containing 1A protein.
          Length = 1134

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 130

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 131 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 241 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 299

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 300 ALIEDH 305



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 251

Query: 572 DYAIYY 577
             A  +
Sbjct: 252 HEAALF 257



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 126

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 127 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 242

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 243 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 292



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 189

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 190 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 291



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 136

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 194

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 195 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 243

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 244 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 278



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 256

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 257 FGKTDVVQILL 267



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 156 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 215 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 271

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 272 DVNIKDNHGLTAL 284


>AL033520-2|CAI20281.1| 1134|Homo sapiens ankyrin repeat and sterile
           alpha motif domain containing 1A protein.
          Length = 1134

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 13/246 (5%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G T LH AA++ H    ++L+ + DA      + G YP+H AA    ++ + 
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVR 130

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + +  G       EQ     +N+    LH A   G  + V++ L      + + +   TP
Sbjct: 131 LLIHQGPSHTRVNEQ-----NNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + LA   G L++VK++    P      L SC+ +K TP+H AA   H  +V  L++ G D
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPN-----LLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV-VMNGGRLEDFA 378
            N    E  S L  AA       V  L+  G D+ +KD +    L  V  +   + +  A
Sbjct: 241 SN-YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIA 299

Query: 379 ASCKDH 384
           A  +DH
Sbjct: 300 ALIEDH 305



 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 59/186 (31%), Positives = 92/186 (49%), Gaps = 2/186 (1%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D+TG +PLH+A+  GH   +E L+R  A  N+ ++    PLH AA  G       L
Sbjct: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLHRDHNGRNPLHLAAMS 511
           +        +NE + +  T LH A++ GHT VV +LL        R++    PL LAA+ 
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
           G  + +++L + H +LL    K  +T LHLA      + + +LL  G   +Y     SA+
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSAL 251

Query: 572 DYAIYY 577
             A  +
Sbjct: 252 HEAALF 257



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 10/233 (4%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G ++N +D    +PL  AA       V  L+R  A   + D      LHL    G   + 
Sbjct: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG---DA 126

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
                  H   S  ++ NE++N   + LH A++ GH   ++ L+       ++NN  E+P
Sbjct: 127 QIVRLLIHQGPSHTRV-NEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETP 185

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH 496
           L  AA YGR      LL++       N       TPLH+A+R GH  VV +LL+ G   +
Sbjct: 186 LDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAGMDSN 242

Query: 497 RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPS 549
                 + LH AA+ G T  +++L +  +   D   KD +    L T+   PS
Sbjct: 243 YQTEMGSALHEAALFGKTDVVQILLAAGT---DVNIKDNHGLTALDTVRELPS 292



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 18/232 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N  D+ G TPLH A  N   D +E LL+    T+V + K   P+H+A       ++++
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 132 FA-KYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEA 189
              +  S   VN+      TALH AA + H    K+L+ +L     +  NN +  P+  A
Sbjct: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR--NNKFETPLDLA 189

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A       +++ L            ++S  + + + PLH A   G    V++ L +G   
Sbjct: 190 ALYGRLEVVKMLLN-------AHPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMD- 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFT----MQPKEKHACLTSCDVQKMTP 297
           S  Q ++ + +H A   G  D+V+++      +  K+ H  LT+ D  +  P
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHG-LTALDTVRELP 291



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 17/215 (7%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ- 102
           D  G T  H A+   + +++  +       N  D+ G  PLH+A        +  L+ Q 
Sbjct: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQG 136

Query: 103 --HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
             H   +  N   +  +H A +     V++V    + L +         T L  AA++  
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVL--LEELTDPTMRNNKFETPLDLAALYGR 194

Query: 161 DLCAKILITDLDAEWKKPCN-NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLY 219
               K+L+          CN   + P+H AA+N     ++V L  G         M S Y
Sbjct: 195 LEVVKMLLNAHPN--LLSCNTKKHTPLHLAARNGHKAVVQVLLDAG---------MDSNY 243

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQH 254
             E    LH A   G    V++ L +G  ++ + +
Sbjct: 244 QTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDN 278



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 3/131 (2%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIE 97
           +R+  ++    TA H A+   +T ++  +     D   ++N   TPL +A     L+ ++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199

Query: 98  YLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAI 157
            LL  H      N K   P+H+A      +V+QV     +  + N   E G +ALH AA+
Sbjct: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL--LDAGMDSNYQTEMG-SALHEAAL 256

Query: 158 HDHDLCAKILI 168
                  +IL+
Sbjct: 257 FGKTDVVQILL 267



 Score = 39.9 bits (89), Expect = 0.052
 Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 4/133 (3%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +  +++ L E +   +R+ +  T    A+      ++  + N   +L + +  
Sbjct: 156 AAQYGHTE-VVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            +TPLH+A  N     ++ LL   ++++   E   A +H A    K  V+Q+     +  
Sbjct: 215 KHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGT-- 271

Query: 140 NVNQGGEHGRTAL 152
           +VN    HG TAL
Sbjct: 272 DVNIKDNHGLTAL 284


>AB037360-1|BAA90300.1| 1166|Homo sapiens ANKHZN protein.
          Length = 1166

 Score = 97.1 bits (231), Expect = 3e-19
 Identities = 123/524 (23%), Positives = 205/524 (39%), Gaps = 37/524 (7%)

Query: 61   NILHFINNYA--GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIH 118
            N LH  NN     D + KD+   T L +A+          LL      +      Q  +H
Sbjct: 566  NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLH 625

Query: 119  MATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKP 178
            MA +           ++++  NV    + G TAL  A  +   L    + T   A+   P
Sbjct: 626  MAIQRQDSKSALFLLEHRADINVRP--QAGETALQLAIRNQLPLVVDAICTR-GADMSVP 682

Query: 179  CNNGYYPIHEAAKNASSRTIEVFLQ-------WGEQRGCTREQMISLYDNEGNVPLHSAV 231
               G  P+  A  N         ++       WG   G   + ++    +E N P    +
Sbjct: 683  DEEGNPPLWLALANNLEDIASTLVRHGCGATCWGPGPGGCLQTLLHRAIDENNEPTACFL 742

Query: 232  --HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
               G D+ +      +G     +  D  TP+HLA + G L+ V+ +      E  A +  
Sbjct: 743  IRSGCDVNSPRQPGANGEG-EEEARDGQTPLHLAASWG-LETVQCLL-----EFGADVNP 795

Query: 290  CDVQKMTPIHCAAMFDHPEIVNYLINEG-SDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
             D +  TP H A    H  I+  L++   S +N  DK+  +P   A +    ++   +++
Sbjct: 796  QDAEGRTPCHVAISSQHGVIIQLLVSHPISSLNVRDKQGLTPFACAMTFKDNKSAEAILK 855

Query: 349  LGADI-QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYA 407
             G+   +  D   RN LH+ V N   +E   +    H   +       +D    +PLH  
Sbjct: 856  RGSGAAEQVDNKGRNSLHVAVQNSD-IESVLSLISVHANVNS----RAQDAPKLTPLHLV 910

Query: 408  SREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDG 467
             +EG    + NL+  GA +     + ++ LH AA+     T C +L  +   F   + +G
Sbjct: 911  VQEGSEIIVRNLLLAGAKVTELTKHRKTALHLAAQED-LPTICSVLLENAVDFAAVDENG 969

Query: 468  EGLTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAAMSGYTKTIEL----LH 521
                 LH+A   G    + +LL    +     N  G++PLH+    G      +    L 
Sbjct: 970  NNA--LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLE 1027

Query: 522  SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             +  + LD+ D DG+T L LA M+   +    ++  G RL  NN
Sbjct: 1028 CMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNN 1071



 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 102/464 (21%), Positives = 173/464 (37%), Gaps = 21/464 (4%)

Query: 47   GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
            G+T  H A  R ++    F+  +  D+N +  AG T L +A+ N+    ++ +  +  + 
Sbjct: 620  GQTLLHMAIQRQDSKSALFLLEHRADINVRPQAGETALQLAIRNQLPLVVDAICTRGADM 679

Query: 107  SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHG--RTALHFAAIHDHDLCA 164
            SV +E+   P+ +A   N   +     ++         G  G  +T LH A   +++  A
Sbjct: 680  SVPDEEGNPPLWLALANNLEDIASTLVRHGCGATCWGPGPGGCLQTLLHRAIDENNEPTA 739

Query: 165  KILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG-EQRGCTRE--QMISLYDN 221
              LI     +   P   G     E         + +   WG E   C  E    ++  D 
Sbjct: 740  CFLIRS-GCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLETVQCLLEFGADVNPQDA 798

Query: 222  EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPK 281
            EG  P H A+       ++L L S    S    D       ACA    D       +  K
Sbjct: 799  EGRTPCHVAISSQHGVIIQL-LVSHPISSLNVRDKQGLTPFACAMTFKDNKSAEAIL--K 855

Query: 282  EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN--PLDKERRSPLLLAASRAG 339
                     D +    +H A      E V  LI+  +++N    D  + +PL L      
Sbjct: 856  RGSGAAEQVDNKGRNSLHVAVQNSDIESVLSLISVHANVNSRAQDAPKLTPLHLVVQEGS 915

Query: 340  WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
               V  L+  GA +     + +  LHL        ED    C    E ++       D  
Sbjct: 916  EIIVRNLLLAGAKVTELTKHRKTALHLAAQ-----EDLPTICSVLLENAV--DFAAVDEN 968

Query: 400  GCSPLHYASREGHIRSLENLI-RLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSD 456
            G + LH A   G + ++  L+          N   +SPLH   +YG+ + A    L    
Sbjct: 969  GNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLEC 1028

Query: 457  KGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN 500
               + +++ D +G T L +A  +G+  +   ++  GA L  ++N
Sbjct: 1029 MPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNN 1072



 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 127/563 (22%), Positives = 213/563 (37%), Gaps = 59/563 (10%)

Query: 42  VRDGRGRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLL 100
           ++D +GRT  H +    +  +  H +     DL  KD+ G+T L +AV++  + +     
Sbjct: 360 MQDSKGRTPLHVSIMAGDEYVFSHLLQCKQLDLELKDHEGSTALWLAVQHITVSS----- 414

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
               + SV N     P+   T  ++ S      +  S  +       G   L  AA   +
Sbjct: 415 ----DQSV-NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTAT-GNCLLQRAAGAGN 468

Query: 161 DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYD 220
           +  A  L T+  A        G  P+H A ++  +      LQ G       E+ + L  
Sbjct: 469 EAAALFLATN-GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPK 527

Query: 221 NEGNV-----------PLHSAV--HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
              ++           PLH A+  +  D+ +V L  ++ A  +T    +     L  ++ 
Sbjct: 528 EAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRD 587

Query: 268 ALDIVKLMFT------MQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
              +   ++T       Q     A +        T +H A      +   +L+   +DIN
Sbjct: 588 QTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHRADIN 647

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASC 381
              +   + L LA        V  +   GAD+ + D      L L + N   LED A++ 
Sbjct: 648 VRPQAGETALQLAIRNQLPLVVDAICTRGADMSVPDEEGNPPLWLALANN--LEDIASTL 705

Query: 382 KDH-CEKSLLQLLNEKDNTGC--SPLHYASREGHIRSLENLIRLGACINLKNN------- 431
             H C  +           GC  + LH A  E +  +   LIR G  +N           
Sbjct: 706 VRHGCGATCWG----PGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEG 761

Query: 432 -----NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVH 486
                + ++PLH AA +G     C LL+       +N  D EG TP H+A    H  ++ 
Sbjct: 762 EEEARDGQTPLHLAASWGLETVQC-LLEFGAD---VNPQDAEGRTPCHVAISSQHGVIIQ 817

Query: 487 LLLNR--GALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATM 544
           LL++    +L  RD  G  P   A      K+ E +    S   +Q+D  G  SLH+A  
Sbjct: 818 LLVSHPISSLNVRDKQGLTPFACAMTFKDNKSAEAILKRGSGAAEQVDNKGRNSLHVAVQ 877

Query: 545 ENKPSSIALLLSMGCRLSYNNMD 567
            +   S+  L+S+   ++    D
Sbjct: 878 NSDIESVLSLISVHANVNSRAQD 900



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 87/357 (24%), Positives = 137/357 (38%), Gaps = 32/357 (8%)

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHAC--------LTSCDVQKMTPIHCAAMFDHP 307
           L TP+H+A A    D+V ++   +    HA          +  D +  T +  A      
Sbjct: 541 LQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMH 600

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
            I   L+  G+ IN    + ++ L +A  R   ++   L+   ADI ++       L L 
Sbjct: 601 TIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHRADINVRPQAGETALQLA 660

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
           + N   L    A C    + S+       D  G  PL  A           L+R G    
Sbjct: 661 IRNQLPLV-VDAICTRGADMSV------PDEEGNPPLWLALANNLEDIASTLVRHGCGAT 713

Query: 428 LKNNNN----ESPLHFAARYGRFHTACQLLDS--------DKGTFIINESDG-EGLTPLH 474
                     ++ LH A       TAC L+ S          G     E +  +G TPLH
Sbjct: 714 CWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLH 773

Query: 475 IASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           +A+  G    V  LL  GA ++ +D  GR P H+A  S +   I+LL S     L+  DK
Sbjct: 774 LAASWG-LETVQCLLEFGADVNPQDAEGRTPCHVAISSQHGVIIQLLVSHPISSLNVRDK 832

Query: 534 DGNTSLHLAT--MENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVT 588
            G T    A    +NK +   L    G     +N   +++  A+     E+ L++++
Sbjct: 833 QGLTPFACAMTFKDNKSAEAILKRGSGAAEQVDNKGRNSLHVAVQNSDIESVLSLIS 889



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 52/228 (22%), Positives = 96/228 (42%), Gaps = 21/228 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++ GA+  ++D   R  LH+ +M G   +++  S    C++  L+L   KD+ G + L 
Sbjct: 351 LLQAGANPNMQDSKGRTPLHVSIMAG---DEYVFSHLLQCKQLDLEL---KDHEGSTALW 404

Query: 406 YASREGHIR-SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
            A +  HI  S +  +     + + N  +     FAAR  +  +     D+  G  ++  
Sbjct: 405 LAVQ--HITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQR 462

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTK-TIELLHSV 523
           + G G               + L  N   + HR+  G  PLH A   G    T ELL   
Sbjct: 463 AAGAG----------NEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG 512

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAI 571
            +  L Q ++        A++ +   S+ L   +   ++YN+ D+ ++
Sbjct: 513 ANPNL-QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSV 559



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 33/101 (32%), Positives = 46/101 (45%), Gaps = 11/101 (10%)

Query: 419 LIRLGACINLKNNN-NESPLHFAARYG-RFHTACQLLDSDKGTFII-------NESDGEG 469
           LI+ GA +N       E+PLH  A Y  R H+A  + +  +    +       N  D +G
Sbjct: 306 LIKNGAFVNAATLGCQETPLHLVALYSSRNHSADVMSEMAQIAEALLQAGANPNMQDSKG 365

Query: 470 LTPLHIASREGHTRVV-HLLLNRGALLH-RDHNGRNPLHLA 508
            TPLH++   G   V  HLL  +   L  +DH G   L LA
Sbjct: 366 RTPLHVSIMAGDEYVFSHLLQCKQLDLELKDHEGSTALWLA 406


>AF308285-1|AAG48253.1| 1188|Homo sapiens serologically defined
           breast cancer antigen NY-BR-16 protein.
          Length = 1188

 Score = 96.7 bits (230), Expect = 4e-19
 Identities = 116/492 (23%), Positives = 205/492 (41%), Gaps = 35/492 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  +      +N     G + L +A      +  + LL  H        K
Sbjct: 240 EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK 299

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A     V ++++   +K+  +VN     G TAL +A    +    K+L+ + 
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKA--DVNAQSSTGNTALTYACAGGYVDVVKVLL-ES 356

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EA          + L+ G          I+ + NE     L  A
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAG--------INTHSNEFKESALTLA 408

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G ++ V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 463

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+ +  ++ E  +PL+ AA       V  L+  G
Sbjct: 464 ADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG LE      K   +  L          GCS PL  A++
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL----------GCSTPLMEAAQ 573

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +  G  + +ES+G G
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA--GADLEHESEG-G 630

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL--HLAAMSGYTKTIELLHSVHSHL 527
            TPL  A+R GH   V  L+++GA    +      +   LA   G+   +ELL +  +  
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGAECESEPQLIMTILSALACAGGHLAVVELLLAHGADP 690

Query: 528 LDQIDKDGNTSL 539
             ++ KDG+T L
Sbjct: 691 THRL-KDGSTML 701



 Score = 80.6 bits (190), Expect = 3e-14
 Identities = 90/368 (24%), Positives = 150/368 (40%), Gaps = 42/368 (11%)

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEK 283
           N  L  A   GD+ AV   L  G  ++    +  + + LAC+ G  ++ +++  M     
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM----- 289

Query: 284 HACLTSCDVQ-KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
           HA +    ++  +TP+  AA   H +IV  L+   +D+N       + L  A +      
Sbjct: 290 HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDV 349

Query: 343 VHTLIRLGADIQLKDINSRN------------VLHLVVMNGGRLEDFAASCKDH-----C 385
           V  L+  GA I+  + N               V  L++ NG  +   +   K+      C
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409

Query: 386 EKSLLQLLNEKDNTGCSPLHY----------ASREGHIRSLENLIRLGACINLKNNNNES 435
            K  L+++      G    H           A  +GH+     L+  GA +N+  ++ ES
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469

Query: 436 PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
           PL  AA  G    A  L++       + E + EG TPL  A+REGH  +V LLL +GA +
Sbjct: 470 PLTLAACGGHVELAALLIERGAS---LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 496 H--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
           +   +      L LA   G+ +  + L    +     I+   +T L  A  E     +  
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGA----DIELGCSTPLMEAAQEGHLELVKY 582

Query: 554 LLSMGCRL 561
           LL+ G  +
Sbjct: 583 LLAAGANV 590



 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 99/465 (21%), Positives = 180/465 (38%), Gaps = 30/465 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K +++  + AA  G+V   ++L L+  + +  +   G TA   A A    +++  +    
Sbjct: 299 KGDITPLMAAANGGHVK-IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVL 129
             +   +  G+TPL  A     ++    LL+     +   NE  ++ + +A     + ++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
           +   +  +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  A
Sbjct: 418 RFLLEAGA--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLA 474

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A         + +    +RG + E++    ++EG  PL  A   G  + V L L  GA I
Sbjct: 475 ACGGHVELAALLI----ERGASLEEV----NDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 250 STQQHDL-STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           + Q  +   T + LAC  G L++   +       +  C         TP+  AA   H E
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--------STPLMEAAQEGHLE 578

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +V YL+  G++++       + L  A           L++ GAD++ +    R  L    
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638

Query: 369 MNGGRLE-DFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
             G      F  S    CE     ++       C+        GH+  +E L+  GA   
Sbjct: 639 RAGHVCTVQFLISKGAECESEPQLIMTILSALACA-------GGHLAVVELLLAHGADPT 691

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
            +  +  + L  A + G     C LLD           D   LTP
Sbjct: 692 HRLKDGSTMLIEAPKGGHTSVGCYLLDYPNNLLSAPPPDVTQLTP 736



 Score = 65.3 bits (152), Expect = 1e-09
 Identities = 66/257 (25%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L+ EG  +N   +E  S L LA S   +     L+ + A+++ + I       +   
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           NGG ++          +      +N + +TG + L YA   G++  ++ L+  GA I   
Sbjct: 310 NGGHVKIVKLLLAHKAD------VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  A   G    A  LL++  G  I   S+    + L +A  +GH  +V  LL
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAG--INTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 480

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 481 ELAALLIERGASLEEVN 497



 Score = 36.7 bits (81), Expect = 0.49
 Identities = 21/42 (50%), Positives = 24/42 (57%), Gaps = 1/42 (2%)

Query: 471  TPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMS 511
            T L +A   GH  +V  LL RGA + HRD  G  PL LAA S
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATS 1126


>BC101273-1|AAI01274.1|  399|Homo sapiens ANKDD1A protein protein.
          Length = 399

 Score = 96.3 bits (229), Expect = 6e-19
 Identities = 84/298 (28%), Positives = 130/298 (43%), Gaps = 17/298 (5%)

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++ +++ + SGAKI  +  D  T +H A  +G + +  L F M+  E  A L   D  
Sbjct: 11  GHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPV--LAFIMEDLEDVA-LDHVDKL 67

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
             T  H AA     + +++L+  G D N  DKE  + L LAA R     +  L+ +G D+
Sbjct: 68  GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           + ++      LH     GG   D           S +  L +K N  C  LHYA+  G  
Sbjct: 128 EEQNAEGLTALHSAA--GGSHPDCVQLLLR--AGSTVNALTQK-NLSC--LHYAALSGSE 180

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
                LI  G C N+ ++   SPLH A R+        L++SD     +N  D    TPL
Sbjct: 181 DVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPL 237

Query: 474 HIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
           H+A+      +  +LL  G     D N R+  H +  SG + + +  H   +  L  +
Sbjct: 238 HLAAEHAWQDIADMLLIAGV----DLNLRDKDHPSDPSGKSLSFKQDHRQETQQLRSV 291



 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 75/278 (26%), Positives = 120/278 (43%), Gaps = 18/278 (6%)

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
           M  +  +A F H  I+  L+N G+ I+   K+  + L  AA +     +  ++    D+ 
Sbjct: 1   MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60

Query: 355 LKDIN--SRNVLHLVVMNG--GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           L  ++   R   H    +G    L+    S  DH         N KD  G + LH A+  
Sbjct: 61  LDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH---------NVKDKEGNTALHLAAGR 111

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           GH+  L+ L+ +G  +  +N    + LH AA  G  H  C  L    G+  +N    + L
Sbjct: 112 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAA--GGSHPDCVQLLLRAGS-TVNALTQKNL 168

Query: 471 TPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           + LH A+  G   V  +L++ G   +  DH G +PLHLA    +   + LL +  S  ++
Sbjct: 169 SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VN 227

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +D    T LHLA          +LL  G  L+  + D
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKD 265



 Score = 77.8 bits (183), Expect = 2e-13
 Identities = 64/241 (26%), Positives = 101/241 (41%), Gaps = 14/241 (5%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWK 176
           +H A +   V VL    +      ++   + GRTA H AA H   L A   +     +  
Sbjct: 37  LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ-LDALDFLVGSGCDHN 95

Query: 177 KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
                G   +H AA       ++  +  G       EQ     + EG   LHSA  G   
Sbjct: 96  VKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQ-----NAEGLTALHSAAGGSHP 147

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMT 296
             V+L LR+G+ ++       + +H A   G+ D+ +++          C    D Q  +
Sbjct: 148 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLI-----HAGGCANVVDHQGAS 202

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+H A   + P +V  LIN  SD+N +D  +++PL LAA  A       L+  G D+ L+
Sbjct: 203 PLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR 262

Query: 357 D 357
           D
Sbjct: 263 D 263



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 60/248 (24%), Positives = 109/248 (43%), Gaps = 13/248 (5%)

Query: 30  MRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD--LNAKDNAGNTPLHVA 87
           +++ ++  +++      G T  H A+ + +  +L FI     D  L+  D  G T  H A
Sbjct: 16  LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 75

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH 147
            E+  LDA+++L+    + +V +++    +H+A     ++VLQ         ++ +    
Sbjct: 76  AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAE 133

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G TALH AA   H  C ++L+    +            +H AA + S     V +  G  
Sbjct: 134 GLTALHSAAGGSHPDCVQLLLR-AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG-- 190

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
            GC      ++ D++G  PLH AV       V L + S + ++   +   TP+HLA    
Sbjct: 191 -GCA-----NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 244

Query: 268 ALDIVKLM 275
             DI  ++
Sbjct: 245 WQDIADML 252



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/183 (27%), Positives = 79/183 (43%), Gaps = 4/183 (2%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K+  + F +AAE G +D    L  S      V+D  G TA H A+ R +  +L  + +  
Sbjct: 66  KLGRTAFHRAAEHGQLDALDFLVGSGCDH-NVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            DL  ++  G T LH A      D ++ LL+     + L +K  + +H A       V +
Sbjct: 125 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 184

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V        NV      G + LH A  H+     ++LI   D++     N    P+H AA
Sbjct: 185 VLIHAGGCANVVD--HQGASPLHLAVRHNFPALVRLLINS-DSDVNAVDNRQQTPLHLAA 241

Query: 191 KNA 193
           ++A
Sbjct: 242 EHA 244



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 46/212 (21%), Positives = 87/212 (41%), Gaps = 11/212 (5%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D  GRTA H+A+     + L F+     D N KD  GNT LH+A     +  ++ L+   
Sbjct: 65  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124

Query: 104 VETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC 163
           ++    N +    +H A   +    +Q+  +  S   VN   +   + LH+AA+   +  
Sbjct: 125 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGS--TVNALTQKNLSCLHYAALSGSEDV 182

Query: 164 AKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +++LI           + G  P+H A ++     + + +          +  ++  DN  
Sbjct: 183 SRVLI-HAGGCANVVDHQGASPLHLAVRHNFPALVRLLI--------NSDSDVNAVDNRQ 233

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
             PLH A         ++ L +G  ++ +  D
Sbjct: 234 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKD 265



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 14/211 (6%)

Query: 468 EGLTPLHIASREGHTRVVHLL---LNRGALLHRDHNGRNPLHLAAMSGYTKTIE-LLHSV 523
           +GLT LH A+++GH  V+  +   L   AL H D  GR   H AA  G    ++ L+ S 
Sbjct: 32  DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIYYKFPEA 582
             H +   DK+GNT+LHLA      + +  L+ +G  L   N + ++A+  A     P+ 
Sbjct: 92  CDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 149

Query: 583 ALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAV--QDKCITKANCKKDSK-SF 639
              ++   +    V AL      C+  A ++    V   +     C    + +  S    
Sbjct: 150 VQLLL---RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 206

Query: 640 YIKYSFEALCPQLMDEDG-TRKSQQAQQIPL 669
            ++++F AL   L++ D         QQ PL
Sbjct: 207 AVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 1/99 (1%)

Query: 10  TKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNY 69
           T+ NLS    AA SG+ +D  R+ +       V D +G +  H A   N   ++  + N 
Sbjct: 164 TQKNLSCLHYAALSGS-EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 222

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
             D+NA DN   TPLH+A E+   D  + LL   V+ ++
Sbjct: 223 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 261


>BC110582-1|AAI10583.1| 1006|Homo sapiens mindbomb homolog 1
           (Drosophila) protein.
          Length = 1006

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 77/264 (29%), Positives = 120/264 (45%), Gaps = 10/264 (3%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +  A+   H +I+  L+ +  D+   DK+    +  AA       +  L R  AD+  
Sbjct: 466 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 525

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           ++   +  LH+ V N G L+         C  SL      +D+ G +PLH A  +     
Sbjct: 526 RNKRRQTPLHIAV-NKGHLQVVKTLLDFGCHPSL------QDSEGDTPLHDAISKKRDDI 578

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           L  L+  GA + + NNN  + LH AA  G       LL      +I++E   +G T LH+
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638

Query: 476 ASREGHTRVVHLLLNRG--ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A+   H  V  LL+++G   L  ++ N +  LHLA    +T+ + LL    +  LD  DK
Sbjct: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAK-LDIQDK 697

Query: 534 DGNTSLHLATMENKPSSIALLLSM 557
           DG+T LH A   +  S +  L  M
Sbjct: 698 DGDTPLHEALRHHTLSQLRQLQDM 721



 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 15/317 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A+++G+VD  ++L L +   +   D  G  A H A+  +   ++  ++  + DLNA++  
Sbjct: 471 ASQNGHVD-ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             TPLH+AV    L  ++ LL      S+ + +   P+H A    +  +L V  +  +  
Sbjct: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGA-- 587

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRT 197
           +V     +G  ALH AA+  +    ++L++ L   W   +  ++GY  +H AA N     
Sbjct: 588 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 647

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ +  G          + + +      LH AV     + V L +R+GAK+  Q  D  
Sbjct: 648 AELLVHQGNAN-------LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700

Query: 258 TPVHLACAQGALDIVKLMFTMQP--KEKHACLTSCDVQKM-TPIHCAAMFDHPEIVNYLI 314
           TP+H A     L  ++ +  MQ   K   A   S +   M      A       I  +L 
Sbjct: 701 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 760

Query: 315 NEGSDINPLDKERRSPL 331
             G+D++  +K+ +SPL
Sbjct: 761 ANGADLSIRNKKGQSPL 777



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 16/262 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G+  + +A   G +  ++L L+    +  +  D    VH A       +++++       
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH-----R 518

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A L + + ++ TP+H A    H ++V  L++ G   +  D E  +PL  A S+     
Sbjct: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 578

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           +  L+  GAD+ + + N  N LH   + G      +A      +     +++EK + G +
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNP----SAMRVLLSKLPRPWIVDEKKDDGYT 634

Query: 403 PLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHT-ACQLLDSDKGTF 460
            LH A+   H+   E L+  G A ++++N N ++ LH A    R HT   +LL       
Sbjct: 635 ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVE--RQHTQIVRLLVRAGAKL 692

Query: 461 IINESDGEGLTPLHIASREGHT 482
            I + DG+  TPLH A R  HT
Sbjct: 693 DIQDKDGD--TPLHEALRH-HT 711



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 7/179 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           LN ++    +PLH A  +GH++ ++ L+  G   +L+++  ++PLH A    R      L
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR----GALLHRDHNGRNPLHLA 508
           L++     I N +   G   LH A+  G+   + +LL++      +  +  +G   LHLA
Sbjct: 583 LEAGADVTITNNN---GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           A++ + +  ELL    +  LD  + +  T+LHLA        + LL+  G +L   + D
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           V+AA +G+V     L L  P         G TA   AS   + +IL  +     D+ A+D
Sbjct: 436 VKAAANGDVAKVEDL-LKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+  +H A   +    IE L +   + +  N++ Q P+H+A     + V++    +  
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             + +     G T LH A     D    +L+ +  A+     NNG+  +H AA   +   
Sbjct: 555 --HPSLQDSEGDTPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSA 611

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDL 256
           + V L         R  ++    ++G   LH A     ++  EL +  G A +  Q  + 
Sbjct: 612 MRVLLS-----KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666

Query: 257 STPVHLACAQGALDIVKLM 275
            T +HLA  +    IV+L+
Sbjct: 667 QTALHLAVERQHTQIVRLL 685



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 2/100 (2%)

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
           G T +  AS+ GH  ++ LLL +   +   D +G   +H AA       IE+LH   S  
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR-GSAD 522

Query: 528 LDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           L+  +K   T LH+A  +     +  LL  GC  S  + +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562


>BC110581-1|AAI10582.1| 1006|Homo sapiens mindbomb homolog 1
           (Drosophila) protein.
          Length = 1006

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 77/264 (29%), Positives = 120/264 (45%), Gaps = 10/264 (3%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +  A+   H +I+  L+ +  D+   DK+    +  AA       +  L R  AD+  
Sbjct: 466 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 525

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           ++   +  LH+ V N G L+         C  SL      +D+ G +PLH A  +     
Sbjct: 526 RNKRRQTPLHIAV-NKGHLQVVKTLLDFGCHPSL------QDSEGDTPLHDAISKKRDDI 578

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           L  L+  GA + + NNN  + LH AA  G       LL      +I++E   +G T LH+
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638

Query: 476 ASREGHTRVVHLLLNRG--ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A+   H  V  LL+++G   L  ++ N +  LHLA    +T+ + LL    +  LD  DK
Sbjct: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAK-LDIQDK 697

Query: 534 DGNTSLHLATMENKPSSIALLLSM 557
           DG+T LH A   +  S +  L  M
Sbjct: 698 DGDTPLHEALRHHTLSQLRQLQDM 721



 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 15/317 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A+++G+VD  ++L L +   +   D  G  A H A+  +   ++  ++  + DLNA++  
Sbjct: 471 ASQNGHVD-ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             TPLH+AV    L  ++ LL      S+ + +   P+H A    +  +L V  +  +  
Sbjct: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGA-- 587

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRT 197
           +V     +G  ALH AA+  +    ++L++ L   W   +  ++GY  +H AA N     
Sbjct: 588 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 647

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ +  G          + + +      LH AV     + V L +R+GAK+  Q  D  
Sbjct: 648 AELLVHQGNAN-------LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700

Query: 258 TPVHLACAQGALDIVKLMFTMQP--KEKHACLTSCDVQKM-TPIHCAAMFDHPEIVNYLI 314
           TP+H A     L  ++ +  MQ   K   A   S +   M      A       I  +L 
Sbjct: 701 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 760

Query: 315 NEGSDINPLDKERRSPL 331
             G+D++  +K+ +SPL
Sbjct: 761 ANGADLSIRNKKGQSPL 777



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 16/262 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G+  + +A   G +  ++L L+    +  +  D    VH A       +++++       
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH-----R 518

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A L + + ++ TP+H A    H ++V  L++ G   +  D E  +PL  A S+     
Sbjct: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 578

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           +  L+  GAD+ + + N  N LH   + G      +A      +     +++EK + G +
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNP----SAMRVLLSKLPRPWIVDEKKDDGYT 634

Query: 403 PLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHT-ACQLLDSDKGTF 460
            LH A+   H+   E L+  G A ++++N N ++ LH A    R HT   +LL       
Sbjct: 635 ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVE--RQHTQIVRLLVRAGAKL 692

Query: 461 IINESDGEGLTPLHIASREGHT 482
            I + DG+  TPLH A R  HT
Sbjct: 693 DIQDKDGD--TPLHEALRH-HT 711



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 7/179 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           LN ++    +PLH A  +GH++ ++ L+  G   +L+++  ++PLH A    R      L
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR----GALLHRDHNGRNPLHLA 508
           L++     I N +   G   LH A+  G+   + +LL++      +  +  +G   LHLA
Sbjct: 583 LEAGADVTITNNN---GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           A++ + +  ELL    +  LD  + +  T+LHLA        + LL+  G +L   + D
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           V+AA +G+V     L L  P         G TA   AS   + +IL  +     D+ A+D
Sbjct: 436 VKAAANGDVAKVEDL-LKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+  +H A   +    IE L +   + +  N++ Q P+H+A     + V++    +  
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             + +     G T LH A     D    +L+ +  A+     NNG+  +H AA   +   
Sbjct: 555 --HPSLQDSEGDTPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSA 611

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDL 256
           + V L         R  ++    ++G   LH A     ++  EL +  G A +  Q  + 
Sbjct: 612 MRVLLS-----KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666

Query: 257 STPVHLACAQGALDIVKLM 275
            T +HLA  +    IV+L+
Sbjct: 667 QTALHLAVERQHTQIVRLL 685



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 2/100 (2%)

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
           G T +  AS+ GH  ++ LLL +   +   D +G   +H AA       IE+LH   S  
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR-GSAD 522

Query: 528 LDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           L+  +K   T LH+A  +     +  LL  GC  S  + +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562


>AY149908-1|AAN75493.1| 1006|Homo sapiens mind bomb protein.
          Length = 1006

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 77/264 (29%), Positives = 120/264 (45%), Gaps = 10/264 (3%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +  A+   H +I+  L+ +  D+   DK+    +  AA       +  L R  AD+  
Sbjct: 466 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 525

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           ++   +  LH+ V N G L+         C  SL      +D+ G +PLH A  +     
Sbjct: 526 RNKRRQTPLHIAV-NKGHLQVVKTLLDFGCHPSL------QDSEGDTPLHDAISKKRDDI 578

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           L  L+  GA + + NNN  + LH AA  G       LL      +I++E   +G T LH+
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638

Query: 476 ASREGHTRVVHLLLNRG--ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A+   H  V  LL+++G   L  ++ N +  LHLA    +T+ + LL    +  LD  DK
Sbjct: 639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAK-LDIQDK 697

Query: 534 DGNTSLHLATMENKPSSIALLLSM 557
           DG+T LH A   +  S +  L  M
Sbjct: 698 DGDTPLHEALRHHTLSQLRQLQDM 721



 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 15/317 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A+++G+VD  ++L L +   +   D  G  A H A+  +   ++  ++  + DLNA++  
Sbjct: 471 ASQNGHVD-ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             TPLH+AV    L  ++ LL      S+ + +   P+H A    +  +L V  +  +  
Sbjct: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGA-- 587

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRT 197
           +V     +G  ALH AA+  +    ++L++ L   W   +  ++GY  +H AA N     
Sbjct: 588 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 647

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ +  G          + + +      LH AV     + V L +R+GAK+  Q  D  
Sbjct: 648 AELLVHQGNAN-------LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700

Query: 258 TPVHLACAQGALDIVKLMFTMQP--KEKHACLTSCDVQKM-TPIHCAAMFDHPEIVNYLI 314
           TP+H A     L  ++ +  MQ   K   A   S +   M      A       I  +L 
Sbjct: 701 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 760

Query: 315 NEGSDINPLDKERRSPL 331
             G+D++  +K+ +SPL
Sbjct: 761 ANGADLSIRNKKGQSPL 777



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 16/262 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G+  + +A   G +  ++L L+    +  +  D    VH A       +++++       
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH-----R 518

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A L + + ++ TP+H A    H ++V  L++ G   +  D E  +PL  A S+     
Sbjct: 519 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 578

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           +  L+  GAD+ + + N  N LH   + G      +A      +     +++EK + G +
Sbjct: 579 LAVLLEAGADVTITNNNGFNALHHAALRGNP----SAMRVLLSKLPRPWIVDEKKDDGYT 634

Query: 403 PLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHT-ACQLLDSDKGTF 460
            LH A+   H+   E L+  G A ++++N N ++ LH A    R HT   +LL       
Sbjct: 635 ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVE--RQHTQIVRLLVRAGAKL 692

Query: 461 IINESDGEGLTPLHIASREGHT 482
            I + DG+  TPLH A R  HT
Sbjct: 693 DIQDKDGD--TPLHEALRH-HT 711



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 7/179 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           LN ++    +PLH A  +GH++ ++ L+  G   +L+++  ++PLH A    R      L
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR----GALLHRDHNGRNPLHLA 508
           L++     I N +   G   LH A+  G+   + +LL++      +  +  +G   LHLA
Sbjct: 583 LEAGADVTITNNN---GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           A++ + +  ELL    +  LD  + +  T+LHLA        + LL+  G +L   + D
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 698



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           V+AA +G+V     L L  P         G TA   AS   + +IL  +     D+ A+D
Sbjct: 436 VKAAANGDVAKVEDL-LKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+  +H A   +    IE L +   + +  N++ Q P+H+A     + V++    +  
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             + +     G T LH A     D    +L+ +  A+     NNG+  +H AA   +   
Sbjct: 555 --HPSLQDSEGDTPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSA 611

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDL 256
           + V L         R  ++    ++G   LH A     ++  EL +  G A +  Q  + 
Sbjct: 612 MRVLLS-----KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666

Query: 257 STPVHLACAQGALDIVKLM 275
            T +HLA  +    IV+L+
Sbjct: 667 QTALHLAVERQHTQIVRLL 685



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 2/100 (2%)

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
           G T +  AS+ GH  ++ LLL +   +   D +G   +H AA       IE+LH   S  
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR-GSAD 522

Query: 528 LDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           L+  +K   T LH+A  +     +  LL  GC  S  + +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 562


>AY147849-1|AAN18023.1|  997|Homo sapiens MINDBOMB protein.
          Length = 997

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 77/264 (29%), Positives = 120/264 (45%), Gaps = 10/264 (3%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +  A+   H +I+  L+ +  D+   DK+    +  AA       +  L R  AD+  
Sbjct: 457 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 516

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           ++   +  LH+ V N G L+         C  SL      +D+ G +PLH A  +     
Sbjct: 517 RNKRRQTPLHIAV-NKGHLQVVKTLLDFGCHPSL------QDSEGDTPLHDAISKKRDDI 569

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           L  L+  GA + + NNN  + LH AA  G       LL      +I++E   +G T LH+
Sbjct: 570 LAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 629

Query: 476 ASREGHTRVVHLLLNRG--ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           A+   H  V  LL+++G   L  ++ N +  LHLA    +T+ + LL    +  LD  DK
Sbjct: 630 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAK-LDIQDK 688

Query: 534 DGNTSLHLATMENKPSSIALLLSM 557
           DG+T LH A   +  S +  L  M
Sbjct: 689 DGDTPLHEALRHHTLSQLRQLQDM 712



 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 15/317 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           A+++G+VD  ++L L +   +   D  G  A H A+  +   ++  ++  + DLNA++  
Sbjct: 462 ASQNGHVD-ILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 520

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             TPLH+AV    L  ++ LL      S+ + +   P+H A    +  +L V  +  +  
Sbjct: 521 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGA-- 578

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRT 197
           +V     +G  ALH AA+  +    ++L++ L   W   +  ++GY  +H AA N     
Sbjct: 579 DVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEV 638

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            E+ +  G          + + +      LH AV     + V L +R+GAK+  Q  D  
Sbjct: 639 AELLVHQGNAN-------LDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 691

Query: 258 TPVHLACAQGALDIVKLMFTMQP--KEKHACLTSCDVQKM-TPIHCAAMFDHPEIVNYLI 314
           TP+H A     L  ++ +  MQ   K   A   S +   M      A       I  +L 
Sbjct: 692 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 751

Query: 315 NEGSDINPLDKERRSPL 331
             G+D++  +K+ +SPL
Sbjct: 752 ANGADLSIRNKKGQSPL 768



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 16/262 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G+  + +A   G +  ++L L+    +  +  D    VH A       +++++       
Sbjct: 455 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLH-----R 509

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
             A L + + ++ TP+H A    H ++V  L++ G   +  D E  +PL  A S+     
Sbjct: 510 GSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDI 569

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           +  L+  GAD+ + + N  N LH   + G      +A      +     +++EK + G +
Sbjct: 570 LAVLLEAGADVTITNNNGFNALHHAALRGNP----SAMRVLLSKLPRPWIVDEKKDDGYT 625

Query: 403 PLHYASREGHIRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHT-ACQLLDSDKGTF 460
            LH A+   H+   E L+  G A ++++N N ++ LH A    R HT   +LL       
Sbjct: 626 ALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVE--RQHTQIVRLLVRAGAKL 683

Query: 461 IINESDGEGLTPLHIASREGHT 482
            I + DG+  TPLH A R  HT
Sbjct: 684 DIQDKDGD--TPLHEALRH-HT 702



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 7/179 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           LN ++    +PLH A  +GH++ ++ L+  G   +L+++  ++PLH A    R      L
Sbjct: 514 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 573

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR----GALLHRDHNGRNPLHLA 508
           L++     I N +   G   LH A+  G+   + +LL++      +  +  +G   LHLA
Sbjct: 574 LEAGADVTITNNN---GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 630

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           A++ + +  ELL    +  LD  + +  T+LHLA        + LL+  G +L   + D
Sbjct: 631 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD 689



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           V+AA +G+V     L L  P         G TA   AS   + +IL  +     D+ A+D
Sbjct: 427 VKAAANGDVAKVEDL-LKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 485

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+  +H A   +    IE L +   + +  N++ Q P+H+A     + V++    +  
Sbjct: 486 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 545

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
             + +     G T LH A     D    +L+ +  A+     NNG+  +H AA   +   
Sbjct: 546 --HPSLQDSEGDTPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSA 602

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDL 256
           + V L         R  ++    ++G   LH A     ++  EL +  G A +  Q  + 
Sbjct: 603 MRVLLS-----KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 657

Query: 257 STPVHLACAQGALDIVKLM 275
            T +HLA  +    IV+L+
Sbjct: 658 QTALHLAVERQHTQIVRLL 676



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 2/100 (2%)

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
           G T +  AS+ GH  ++ LLL +   +   D +G   +H AA       IE+LH   S  
Sbjct: 455 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR-GSAD 513

Query: 528 LDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           L+  +K   T LH+A  +     +  LL  GC  S  + +
Sbjct: 514 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE 553


>BC130610-1|AAI30611.1| 1672|Homo sapiens KIDINS220 protein protein.
          Length = 1672

 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 107/389 (27%), Positives = 168/389 (43%), Gaps = 39/389 (10%)

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMF 276
           +L D +    L SA   G +  VE  L+ G  +  +     T +  AC +G  D+V+L+ 
Sbjct: 23  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 82

Query: 277 TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
           +         L S     + PI  AA   H +IV+ L+  G+ +N  DK   +PL+ AA 
Sbjct: 83  SHGANPSVTGLYS-----VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 137

Query: 337 RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG---------------------GRLE 375
           +     V  L+ +GAD+  +  NS   L + V  G                     G   
Sbjct: 138 KGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA 197

Query: 376 DFAASCKDHCE--KSLLQ---LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AS + H E  + LL     +N  D +G + L  A R GH+  +  L++  A I+++ 
Sbjct: 198 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 257

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +N++ L++A   G       +L  +  T I  + DGE  TPL  A++  +  VV LLL+
Sbjct: 258 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTK-DGE--TPLIKATKMRNIEVVELLLD 314

Query: 491 RGALLHR-DHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENK 547
           +GA +   D  G  PLH+A      K  ELL  +     LL + +K G T  ++     K
Sbjct: 315 KGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 374

Query: 548 PSSIALLLSMGCRLSYNNMDMSAIDYAIY 576
             SI   +     LS    D   + Y +Y
Sbjct: 375 --SILTQIFGARHLSPTETDGDMLGYDLY 401



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 81/337 (24%), Positives = 144/337 (42%), Gaps = 23/337 (6%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G+++ V+  +++GA  + +  D  T +  A  +G + IV+ +       +H     
Sbjct: 3   AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHR---- 58

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
            D+   T +  A      ++V  L++ G++ +        P++ AA R     VH L++ 
Sbjct: 59  -DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 117

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSP---LHY 406
           GA +   D      L +     G LE         C K LL +  + D  G +    L  
Sbjct: 118 GAKVNCSDKYGTTPL-VWAARKGHLE---------CVKHLLAMGADVDQEGANSMTALIV 167

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A + G+ +S++ +++    +NL + +  + L  A++ G       LLD+  GT++ N  D
Sbjct: 168 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA--GTYV-NIPD 224

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
             G T L  A R GH  +V  LL + A +  R  + +  L+ A   G    +  +   + 
Sbjct: 225 RSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNP 284

Query: 526 HLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
              +   KDG T L  AT       + LLL  G ++S
Sbjct: 285 DT-EICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 320



 Score = 65.3 bits (152), Expect = 1e-09
 Identities = 74/292 (25%), Positives = 125/292 (42%), Gaps = 20/292 (6%)

Query: 184 YPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCL 243
           YPI  AA    +  + + LQ G +  C+        D  G  PL  A   G ++ V+  L
Sbjct: 97  YPIIWAAGRGHADIVHLLLQNGAKVNCS--------DKYGTTPLVWAARKGHLECVKHLL 148

Query: 244 RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
             GA +  +  +  T + +A   G    VK +    P      LT  D    T +  A+ 
Sbjct: 149 AMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVN---LTDKDGN--TALMIASK 203

Query: 304 FDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNV 363
             H EIV  L++ G+ +N  D+   + L+ A        V  L++  ADI ++  +++  
Sbjct: 204 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 263

Query: 364 LHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLG 423
           L+  V  G      A   +D  + +    +  KD  G +PL  A++  +I  +E L+  G
Sbjct: 264 LYWAVEKGN-----ATMVRDILQCNPDTEICTKD--GETPLIKATKMRNIEVVELLLDKG 316

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
           A ++  +   ++PLH A R      A  LL + K   ++   +  G TP +I
Sbjct: 317 AKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 368



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 65/228 (28%), Positives = 108/228 (47%), Gaps = 12/228 (5%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           ++AA +     V  LI+ GA+  L+D+++   L +     G +       K  C  +L  
Sbjct: 1   MIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL-ISASKEGHVHIVEELLK--CGVNL-- 55

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
               +D  G + L +A  +G    +E L+  GA  ++    +  P+ +AA  GR H    
Sbjct: 56  --EHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAA--GRGHADIV 111

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAM 510
            L    G  + N SD  G TPL  A+R+GH   V  LL  GA + ++  N    L +A  
Sbjct: 112 HLLLQNGAKV-NCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVK 170

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            GYT++++ +   + ++ +  DKDGNT+L +A+ E     +  LL  G
Sbjct: 171 GGYTQSVKEILKRNPNV-NLTDKDGNTALMIASKEGHTEIVQDLLDAG 217



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/254 (22%), Positives = 95/254 (37%), Gaps = 29/254 (11%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+ R + +I+H +      +N  D  G TPL  A     L+ +++LL    +        
Sbjct: 102 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 161

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
              + +A +      ++   K     NVN   + G TAL  A+   H    + L+ D   
Sbjct: 162 MTALIVAVKGGYTQSVKEILKRNP--NVNLTDKDGNTALMIASKEGHTEIVQDLL-DAGT 218

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQ-----------------WGEQRG---CTRE 213
               P  +G   +  A +      +   LQ                 W  ++G     R+
Sbjct: 219 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 278

Query: 214 QMISLYDNE-----GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
            +    D E     G  PL  A    +I+ VEL L  GAK+S       TP+H+A    +
Sbjct: 279 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 338

Query: 269 LDIVKLMFTMQPKE 282
             + +L+    PK+
Sbjct: 339 RKLAELLL-RNPKD 351



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 1/103 (0%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + A   G+V+  +R  L + + + +R    +TA + A  + N  ++  I     D     
Sbjct: 232 IGAVRGGHVE-IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT 290

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
             G TPL  A +   ++ +E LL +  + S +++K   P+H+A
Sbjct: 291 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 333



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 37/191 (19%), Positives = 80/191 (41%), Gaps = 4/191 (2%)

Query: 13  NLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD 72
           +++  + A + G       +    P+ + + D  G TA   AS   +T I+  + +    
Sbjct: 161 SMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 219

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N  D +G+T L  AV    ++ +  LLQ++ +  +  +  +  ++ A E    ++++  
Sbjct: 220 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 279

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            +     +     + G T L   A    ++    L+ D  A+       G  P+H A + 
Sbjct: 280 LQCNP--DTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 336

Query: 193 ASSRTIEVFLQ 203
            S +  E+ L+
Sbjct: 337 RSRKLAELLLR 347


>BC032354-1|AAH32354.1|  587|Homo sapiens ankyrin repeat and SOCS
           box-containing 2 protein.
          Length = 587

 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 87/341 (25%), Positives = 155/341 (45%), Gaps = 22/341 (6%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD +A++  ++ G  ++    +   P+H A   G +  +K++    P     
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP----G 115

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            +    +Q+ T ++ A    H + +  L+  G++ +  +K R +PL  A  R     V  
Sbjct: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++  AD   +       LH  V     LE          +      +  K+  G +PL 
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRND-LEVMQILVSGGAK------VESKNAYGITPLF 228

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
            A++ G + +L  L + GA IN + ++N S L+ A +         LL         N++
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA---NKT 285

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS--- 522
           + +GL PLHIAS++G+ R+V +LL   +      +G +PLHLAA   + + +E L S   
Sbjct: 286 NKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARF 345

Query: 523 -VHSHLLDQ---IDKDGNTS-LHLATMENKPSSIALLLSMG 558
            V++ L  +   + +D  +S L+ A + N   +  LLL  G
Sbjct: 346 DVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG 386



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 66/312 (21%), Positives = 134/312 (42%), Gaps = 20/312 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINN-YAGDLNAK 76
           ++A + G+ ++ ++  + E   LA  +  G    H+A+       L  +   Y G ++ +
Sbjct: 62  IKAIKDGD-EEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
                T +++A     LD +  LLQ   E  + N+  + P++ A E      +++  ++ 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  + N     G TALH  ++  +DL    ++    A+ +     G  P+  AA++    
Sbjct: 181 A--DTNHRCNRGWTALH-ESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            +    ++G          I+   ++    L+ A      + VE  L  GA  +    D 
Sbjct: 238 ALRFLAKYGAD--------INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG 289

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
             P+H+A  +G   IV+++  +  +      T      ++P+H AA  +H E++  L++ 
Sbjct: 290 LLPLHIASKKGNYRIVQMLLPVTSR------TRIRRSGVSPLHLAAERNHDEVLEALLSA 343

Query: 317 GSDIN-PLDKER 327
             D+N PL  ER
Sbjct: 344 RFDVNTPLAPER 355



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/234 (21%), Positives = 105/234 (44%), Gaps = 8/234 (3%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           R  RG TA H++ +RN+  ++  + +    + +K+  G TPL VA ++  L+A+ +L + 
Sbjct: 186 RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
             + +       + ++ A +     V++      +  + N+  + G   LH A+   +  
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGA--DANKTNKDGLLPLHIASKKGNYR 303

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG-EQRGCTREQMISLYDN 221
             ++L+        +   +G  P+H AA+      +E  L    +       +   LY++
Sbjct: 304 IVQMLLPVTSR--TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED 361

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
             +  L+ AV   ++ A EL L+ GA       D+ +P+ +A   G L  ++L+
Sbjct: 362 RRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLL 412



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 16/278 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T L+ A    +    KIL+   +A+    CN G+  +HE+        +++ +  G +  
Sbjct: 159 TPLYKACERKNAEAVKILVQH-NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAK-- 215

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                 +   +  G  PL  A   G ++A+    + GA I+TQ  D ++ ++ AC     
Sbjct: 216 ------VESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 269

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           ++V+ + +     + A     +   + P+H A+   +  IV  L+   S    + +   S
Sbjct: 270 EVVEFLLS-----QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR-IRRSGVS 323

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSL 389
           PL LAA R     +  L+    D+       R  L+        L     +   +  + L
Sbjct: 324 PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY-EDRRSSALYFAVVNNNVYATELL 382

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
           LQ   + +    SPL  A R G +R+++ L+  GA I+
Sbjct: 383 LQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420



 Score = 52.4 bits (120), Expect = 9e-06
 Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 10/218 (4%)

Query: 377 FAASCKDH--CEKSLLQLLNEKDNTGCS---PLHYASREGHIRSLENLIRLGACINLKNN 431
           + A+C+ H  C  SLLQ   E D +  S   PL+ A    +  +++ L++  A  N + N
Sbjct: 129 YLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN 188

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              + LH +          Q+L S  G   +   +  G+TPL +A++ G    +  L   
Sbjct: 189 RGWTALHESVSRNDLEVM-QILVS--GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 492 GALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GA ++    +  + L+ A  + + + +E L S  +   ++ +KDG   LH+A+ +     
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADA-NKTNKDGLLPLHIASKKGNYRI 304

Query: 551 IALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVT 588
           + +LL +  R       +S +  A      E   A+++
Sbjct: 305 VQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLS 342



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 2/120 (1%)

Query: 472 PLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           PL  A ++G    +  ++  G  L   +  G  PLH AA  G    +++L   +   +DQ
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDY-AIYYKFPEAALAMVTH 589
                 T+++LAT       +  LL  G     +N       Y A   K  EA   +V H
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179


>AJ251238-1|CAC17765.1|  587|Homo sapiens hypothetical protein
           protein.
          Length = 587

 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 87/341 (25%), Positives = 155/341 (45%), Gaps = 22/341 (6%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD +A++  ++ G  ++    +   P+H A   G +  +K++    P     
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP----G 115

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            +    +Q+ T ++ A    H + +  L+  G++ +  +K R +PL  A  R     V  
Sbjct: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++  AD   +       LH  V     LE          +      +  K+  G +PL 
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRND-LEVMQILVSGGAK------VESKNAYGITPLF 228

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
            A++ G + +L  L + GA IN + ++N S L+ A +         LL         N++
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA---NKT 285

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS--- 522
           + +GL PLHIAS++G+ R+V +LL   +      +G +PLHLAA   + + +E L S   
Sbjct: 286 NKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARF 345

Query: 523 -VHSHLLDQ---IDKDGNTS-LHLATMENKPSSIALLLSMG 558
            V++ L  +   + +D  +S L+ A + N   +  LLL  G
Sbjct: 346 DVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG 386



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 66/312 (21%), Positives = 134/312 (42%), Gaps = 20/312 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINN-YAGDLNAK 76
           ++A + G+ ++ ++  + E   LA  +  G    H+A+       L  +   Y G ++ +
Sbjct: 62  IKAIKDGD-EEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
                T +++A     LD +  LLQ   E  + N+  + P++ A E      +++  ++ 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  + N     G TALH  ++  +DL    ++    A+ +     G  P+  AA++    
Sbjct: 181 A--DTNHRCNRGWTALH-ESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            +    ++G          I+   ++    L+ A      + VE  L  GA  +    D 
Sbjct: 238 ALRFLAKYGAD--------INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG 289

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
             P+H+A  +G   IV+++  +  +      T      ++P+H AA  +H E++  L++ 
Sbjct: 290 LLPLHIASKKGNYRIVQMLLPVTSR------TRIRRSGVSPLHLAAERNHDEVLEALLSA 343

Query: 317 GSDIN-PLDKER 327
             D+N PL  ER
Sbjct: 344 RFDVNTPLAPER 355



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/234 (21%), Positives = 105/234 (44%), Gaps = 8/234 (3%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           R  RG TA H++ +RN+  ++  + +    + +K+  G TPL VA ++  L+A+ +L + 
Sbjct: 186 RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
             + +       + ++ A +     V++      +  + N+  + G   LH A+   +  
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGA--DANKTNKDGLLPLHIASKKGNYR 303

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG-EQRGCTREQMISLYDN 221
             ++L+        +   +G  P+H AA+      +E  L    +       +   LY++
Sbjct: 304 IVQMLLPVTSR--TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED 361

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
             +  L+ AV   ++ A EL L+ GA       D+ +P+ +A   G L  ++L+
Sbjct: 362 RRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLL 412



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 16/278 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T L+ A    +    KIL+   +A+    CN G+  +HE+        +++ +  G +  
Sbjct: 159 TPLYKACERKNAEAVKILVQH-NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAK-- 215

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                 +   +  G  PL  A   G ++A+    + GA I+TQ  D ++ ++ AC     
Sbjct: 216 ------VESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 269

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           ++V+ + +     + A     +   + P+H A+   +  IV  L+   S    + +   S
Sbjct: 270 EVVEFLLS-----QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR-IRRSGVS 323

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSL 389
           PL LAA R     +  L+    D+       R  L+        L     +   +  + L
Sbjct: 324 PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY-EDRRSSALYFAVVNNNVYATELL 382

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
           LQ   + +    SPL  A R G +R+++ L+  GA I+
Sbjct: 383 LQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420



 Score = 52.4 bits (120), Expect = 9e-06
 Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 10/218 (4%)

Query: 377 FAASCKDH--CEKSLLQLLNEKDNTGCS---PLHYASREGHIRSLENLIRLGACINLKNN 431
           + A+C+ H  C  SLLQ   E D +  S   PL+ A    +  +++ L++  A  N + N
Sbjct: 129 YLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN 188

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              + LH +          Q+L S  G   +   +  G+TPL +A++ G    +  L   
Sbjct: 189 RGWTALHESVSRNDLEVM-QILVS--GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 492 GALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GA ++    +  + L+ A  + + + +E L S  +   ++ +KDG   LH+A+ +     
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADA-NKTNKDGLLPLHIASKKGNYRI 304

Query: 551 IALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVT 588
           + +LL +  R       +S +  A      E   A+++
Sbjct: 305 VQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLS 342



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 2/120 (1%)

Query: 472 PLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           PL  A ++G    +  ++  G  L   +  G  PLH AA  G    +++L   +   +DQ
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDY-AIYYKFPEAALAMVTH 589
                 T+++LAT       +  LL  G     +N       Y A   K  EA   +V H
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179


>AB056723-1|BAB64532.1|  587|Homo sapiens ankyrin repeat-conteining
           protein with a SOCS box-2 protein.
          Length = 587

 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 87/341 (25%), Positives = 155/341 (45%), Gaps = 22/341 (6%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD +A++  ++ G  ++    +   P+H A   G +  +K++    P     
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP----G 115

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            +    +Q+ T ++ A    H + +  L+  G++ +  +K R +PL  A  R     V  
Sbjct: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++  AD   +       LH  V     LE          +      +  K+  G +PL 
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRND-LEVMQILVSGGAK------VESKNAYGITPLF 228

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
            A++ G + +L  L + GA IN + ++N S L+ A +         LL         N++
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA---NKT 285

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS--- 522
           + +GL PLHIAS++G+ R+V +LL   +      +G +PLHLAA   + + +E L S   
Sbjct: 286 NKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARF 345

Query: 523 -VHSHLLDQ---IDKDGNTS-LHLATMENKPSSIALLLSMG 558
            V++ L  +   + +D  +S L+ A + N   +  LLL  G
Sbjct: 346 DVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG 386



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 66/312 (21%), Positives = 134/312 (42%), Gaps = 20/312 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINN-YAGDLNAK 76
           ++A + G+ ++ ++  + E   LA  +  G    H+A+       L  +   Y G ++ +
Sbjct: 62  IKAIKDGD-EEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
                T +++A     LD +  LLQ   E  + N+  + P++ A E      +++  ++ 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  + N     G TALH  ++  +DL    ++    A+ +     G  P+  AA++    
Sbjct: 181 A--DTNHRCNRGWTALH-ESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            +    ++G          I+   ++    L+ A      + VE  L  GA  +    D 
Sbjct: 238 ALRFLAKYGAD--------INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG 289

Query: 257 STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE 316
             P+H+A  +G   IV+++  +  +      T      ++P+H AA  +H E++  L++ 
Sbjct: 290 LLPLHIASKKGNYRIVQMLLPVTSR------TRIRRSGVSPLHLAAERNHDEVLEALLSA 343

Query: 317 GSDIN-PLDKER 327
             D+N PL  ER
Sbjct: 344 RFDVNTPLAPER 355



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/234 (21%), Positives = 105/234 (44%), Gaps = 8/234 (3%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           R  RG TA H++ +RN+  ++  + +    + +K+  G TPL VA ++  L+A+ +L + 
Sbjct: 186 RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
             + +       + ++ A +     V++      +  + N+  + G   LH A+   +  
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGA--DANKTNKDGLLPLHIASKKGNYR 303

Query: 163 CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG-EQRGCTREQMISLYDN 221
             ++L+        +   +G  P+H AA+      +E  L    +       +   LY++
Sbjct: 304 IVQMLLPVTSR--TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED 361

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
             +  L+ AV   ++ A EL L+ GA       D+ +P+ +A   G L  ++L+
Sbjct: 362 RRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLL 412



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 16/278 (5%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T L+ A    +    KIL+   +A+    CN G+  +HE+        +++ +  G +  
Sbjct: 159 TPLYKACERKNAEAVKILVQH-NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAK-- 215

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
                 +   +  G  PL  A   G ++A+    + GA I+TQ  D ++ ++ AC     
Sbjct: 216 ------VESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 269

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           ++V+ + +     + A     +   + P+H A+   +  IV  L+   S    + +   S
Sbjct: 270 EVVEFLLS-----QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR-IRRSGVS 323

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSL 389
           PL LAA R     +  L+    D+       R  L+        L     +   +  + L
Sbjct: 324 PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY-EDRRSSALYFAVVNNNVYATELL 382

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
           LQ   + +    SPL  A R G +R+++ L+  GA I+
Sbjct: 383 LQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420



 Score = 52.4 bits (120), Expect = 9e-06
 Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 10/218 (4%)

Query: 377 FAASCKDH--CEKSLLQLLNEKDNTGCS---PLHYASREGHIRSLENLIRLGACINLKNN 431
           + A+C+ H  C  SLLQ   E D +  S   PL+ A    +  +++ L++  A  N + N
Sbjct: 129 YLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN 188

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              + LH +          Q+L S  G   +   +  G+TPL +A++ G    +  L   
Sbjct: 189 RGWTALHESVSRNDLEVM-QILVS--GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245

Query: 492 GALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GA ++    +  + L+ A  + + + +E L S  +   ++ +KDG   LH+A+ +     
Sbjct: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADA-NKTNKDGLLPLHIASKKGNYRI 304

Query: 551 IALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVT 588
           + +LL +  R       +S +  A      E   A+++
Sbjct: 305 VQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLS 342



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 2/120 (1%)

Query: 472 PLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           PL  A ++G    +  ++  G  L   +  G  PLH AA  G    +++L   +   +DQ
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDY-AIYYKFPEAALAMVTH 589
                 T+++LAT       +  LL  G     +N       Y A   K  EA   +V H
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179


>AB033076-1|BAA86564.2| 1777|Homo sapiens KIAA1250 protein protein.
          Length = 1777

 Score = 95.1 bits (226), Expect = 1e-18
 Identities = 107/389 (27%), Positives = 168/389 (43%), Gaps = 39/389 (10%)

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMF 276
           +L D +    L SA   G +  VE  L+ G  +  +     T +  AC +G  D+V+L+ 
Sbjct: 71  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 130

Query: 277 TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
           +         L S     + PI  AA   H +IV+ L+  G+ +N  DK   +PL+ AA 
Sbjct: 131 SHGANPSVTGLYS-----VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 185

Query: 337 RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG---------------------GRLE 375
           +     V  L+ +GAD+  +  NS   L + V  G                     G   
Sbjct: 186 KGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA 245

Query: 376 DFAASCKDHCE--KSLLQ---LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AS + H E  + LL     +N  D +G + L  A R GH+  +  L++  A I+++ 
Sbjct: 246 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 305

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +N++ L++A   G       +L  +  T I  + DGE  TPL  A++  +  VV LLL+
Sbjct: 306 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTK-DGE--TPLIKATKMRNIEVVELLLD 362

Query: 491 RGALLHR-DHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENK 547
           +GA +   D  G  PLH+A      K  ELL  +     LL + +K G T  ++     K
Sbjct: 363 KGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 422

Query: 548 PSSIALLLSMGCRLSYNNMDMSAIDYAIY 576
             SI   +     LS    D   + Y +Y
Sbjct: 423 --SILTQIFGARHLSPTETDGDMLGYDLY 449



 Score = 82.2 bits (194), Expect = 1e-14
 Identities = 79/322 (24%), Positives = 147/322 (45%), Gaps = 17/322 (5%)

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK 294
           +I A++  L     +  +     TP+ +A  QG L+IVK +     K    C    D+  
Sbjct: 23  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI----KNGANCNLE-DLDN 77

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
            T +  A+   H  IV  L+  G ++   D    + L+ A  +     V  L+  GA+  
Sbjct: 78  WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 137

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
           +  + S  V  ++   G    D       +  K     +N  D  G +PL +A+R+GH+ 
Sbjct: 138 VTGLYS--VYPIIWAAGRGHADIVHLLLQNGAK-----VNCSDKYGTTPLVWAARKGHLE 190

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLH 474
            +++L+ +GA ++ +  N+ + L  A + G   +  ++L  +     +N +D +G T L 
Sbjct: 191 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN---VNLTDKDGNTALM 247

Query: 475 IASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           IAS+EGHT +V  LL+ G  ++  D +G   L  A   G+ + +  L   ++  +D   +
Sbjct: 248 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD-IDIRGQ 306

Query: 534 DGNTSLHLATMENKPSSIALLL 555
           D  T+L+ A  +   + +  +L
Sbjct: 307 DNKTALYWAVEKGNATMVRDIL 328



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 84/344 (24%), Positives = 147/344 (42%), Gaps = 23/344 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G  PL  A   G+++ V+  +++GA  + +  D  T +  A  +G + IV+ +       
Sbjct: 44  GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 103

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
           +H      D+   T +  A      ++V  L++ G++ +        P++ AA R     
Sbjct: 104 EHR-----DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADI 158

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           VH L++ GA +   D      L +     G LE         C K LL +  + D  G +
Sbjct: 159 VHLLLQNGAKVNCSDKYGTTPL-VWAARKGHLE---------CVKHLLAMGADVDQEGAN 208

Query: 403 P---LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               L  A + G+ +S++ +++    +NL + +  + L  A++ G       LLD+  GT
Sbjct: 209 SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA--GT 266

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIE 518
           ++ N  D  G T L  A R GH  +V  LL + A +  R  + +  L+ A   G    + 
Sbjct: 267 YV-NIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 325

Query: 519 LLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
            +   +    +   KDG T L  AT       + LLL  G ++S
Sbjct: 326 DILQCNPDT-EICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 368



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 94/404 (23%), Positives = 170/404 (42%), Gaps = 23/404 (5%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D++ ++  G TPL +A E   L+ ++ L++     ++ +      +  A++   V +++ 
Sbjct: 36  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 95

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
             K     N+      G TAL +A         ++L++   A          YPI  AA 
Sbjct: 96  LLKCG--VNLEHRDMGGWTALMWACYKGRTDVVELLLSH-GANPSVTGLYSVYPIIWAAG 152

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
              +  + + LQ G +  C+        D  G  PL  A   G ++ V+  L  GA +  
Sbjct: 153 RGHADIVHLLLQNGAKVNCS--------DKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 204

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN 311
           +  +  T + +A   G    VK +    P      LT  D    T +  A+   H EIV 
Sbjct: 205 EGANSMTALIVAVKGGYTQSVKEILKRNPNVN---LTDKDGN--TALMIASKEGHTEIVQ 259

Query: 312 YLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            L++ G+ +N  D+   + L+ A        V  L++  ADI ++  +++  L+  V  G
Sbjct: 260 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 319

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
                 A   +D  + +    +  KD  G +PL  A++  +I  +E L+  GA ++  + 
Sbjct: 320 N-----ATMVRDILQCNPDTEICTKD--GETPLIKATKMRNIEVVELLLDKGAKVSAVDK 372

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
             ++PLH A R      A  LL + K   ++   +  G TP +I
Sbjct: 373 KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 416



 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 69/247 (27%), Positives = 120/247 (48%), Gaps = 12/247 (4%)

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L+ +  D++  ++  ++PL++AA +     V  LI+ GA+  L+D+++   L +     G
Sbjct: 30  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL-ISASKEG 88

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            +       K  C  +    L  +D  G + L +A  +G    +E L+  GA  ++    
Sbjct: 89  HVHIVEELLK--CGVN----LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 142

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
           +  P+ +AA  GR H     L    G   +N SD  G TPL  A+R+GH   V  LL  G
Sbjct: 143 SVYPIIWAA--GRGHADIVHLLLQNGA-KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 199

Query: 493 ALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A + ++  N    L +A   GYT++++ +   + + ++  DKDGNT+L +A+ E     +
Sbjct: 200 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGHTEIV 258

Query: 552 ALLLSMG 558
             LL  G
Sbjct: 259 QDLLDAG 265



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 53/185 (28%), Positives = 89/185 (48%), Gaps = 6/185 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           ++E++  G +PL  A+ +G++  ++ LI+ GA  NL++ +N + L  A++ G  H   +L
Sbjct: 37  VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 96

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L   K    +   D  G T L  A  +G T VV LLL+ GA           P+  AA  
Sbjct: 97  L---KCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGR 153

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSA 570
           G+   + LL   +   ++  DK G T L  A  +     +  LL+MG  +     + M+A
Sbjct: 154 GHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTA 212

Query: 571 IDYAI 575
           +  A+
Sbjct: 213 LIVAV 217



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/254 (22%), Positives = 95/254 (37%), Gaps = 29/254 (11%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+ R + +I+H +      +N  D  G TPL  A     L+ +++LL    +        
Sbjct: 150 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 209

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
              + +A +      ++   K     NVN   + G TAL  A+   H    + L+ D   
Sbjct: 210 MTALIVAVKGGYTQSVKEILKRNP--NVNLTDKDGNTALMIASKEGHTEIVQDLL-DAGT 266

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQ-----------------WGEQRG---CTRE 213
               P  +G   +  A +      +   LQ                 W  ++G     R+
Sbjct: 267 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 326

Query: 214 QMISLYDNE-----GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
            +    D E     G  PL  A    +I+ VEL L  GAK+S       TP+H+A    +
Sbjct: 327 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 386

Query: 269 LDIVKLMFTMQPKE 282
             + +L+    PK+
Sbjct: 387 RKLAELLL-RNPKD 399



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 1/103 (0%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + A   G+V+  +R  L + + + +R    +TA + A  + N  ++  I     D     
Sbjct: 280 IGAVRGGHVE-IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT 338

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
             G TPL  A +   ++ +E LL +  + S +++K   P+H+A
Sbjct: 339 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 381



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 37/191 (19%), Positives = 80/191 (41%), Gaps = 4/191 (2%)

Query: 13  NLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD 72
           +++  + A + G       +    P+ + + D  G TA   AS   +T I+  + +    
Sbjct: 209 SMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 267

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N  D +G+T L  AV    ++ +  LLQ++ +  +  +  +  ++ A E    ++++  
Sbjct: 268 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 327

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            +     +     + G T L   A    ++    L+ D  A+       G  P+H A + 
Sbjct: 328 LQCNP--DTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 384

Query: 193 ASSRTIEVFLQ 203
            S +  E+ L+
Sbjct: 385 RSRKLAELLLR 395


>AL133620-1|CAB63746.1| 1031|Homo sapiens hypothetical protein
           protein.
          Length = 1031

 Score = 94.3 bits (224), Expect = 2e-18
 Identities = 106/389 (27%), Positives = 167/389 (42%), Gaps = 38/389 (9%)

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMF 276
           +L D +    L SA   G +  VE  L+ G  +  +     T +  AC +G  D+V+L+ 
Sbjct: 65  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124

Query: 277 TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
           +         L       + PI  AA   H +IV+ L+  G+ +N  DK   +PL+ AA 
Sbjct: 125 SHGANPSVTGLQ----YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 180

Query: 337 RAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG---------------------GRLE 375
           +     V  L+ +GAD+  +  NS   L + V  G                     G   
Sbjct: 181 KGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA 240

Query: 376 DFAASCKDHCE--KSLLQ---LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN 430
              AS + H E  + LL     +N  D +G + L  A R GH+  +  L++  A I+++ 
Sbjct: 241 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 300

Query: 431 NNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLN 490
            +N++ L++A   G       +L  +  T I  + DGE  TPL  A++  +  VV LLL+
Sbjct: 301 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTK-DGE--TPLIKATKMRNIEVVELLLD 357

Query: 491 RGALLHR-DHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATMENK 547
           +GA +   D  G  PLH+A      K  ELL  +     LL + +K G T  ++     K
Sbjct: 358 KGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 417

Query: 548 PSSIALLLSMGCRLSYNNMDMSAIDYAIY 576
             SI   +     LS    D   + Y +Y
Sbjct: 418 --SILTQIFGARHLSPTETDGDMLGYDLY 444



 Score = 81.8 bits (193), Expect = 1e-14
 Identities = 78/322 (24%), Positives = 147/322 (45%), Gaps = 16/322 (4%)

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK 294
           +I A++  L     +  +     TP+ +A  QG L+IVK +     K    C    D+  
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI----KNGANCNLE-DLDN 71

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
            T +  A+   H  IV  L+  G ++   D    + L+ A  +     V  L+  GA+  
Sbjct: 72  WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
           +  +   +V  ++   G    D       +  K     +N  D  G +PL +A+R+GH+ 
Sbjct: 132 VTGL-QYSVYPIIWAAGRGHADIVHLLLQNGAK-----VNCSDKYGTTPLVWAARKGHLE 185

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLH 474
            +++L+ +GA ++ +  N+ + L  A + G   +  ++L  +     +N +D +G T L 
Sbjct: 186 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN---VNLTDKDGNTALM 242

Query: 475 IASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDK 533
           IAS+EGHT +V  LL+ G  ++  D +G   L  A   G+ + +  L   ++  +D   +
Sbjct: 243 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD-IDIRGQ 301

Query: 534 DGNTSLHLATMENKPSSIALLL 555
           D  T+L+ A  +   + +  +L
Sbjct: 302 DNKTALYWAVEKGNATMVRDIL 323



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 93/404 (23%), Positives = 169/404 (41%), Gaps = 22/404 (5%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           D++ ++  G TPL +A E   L+ ++ L++     ++ +      +  A++   V +++ 
Sbjct: 30  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAK 191
             K     N+      G TAL +A         ++L++              YPI  AA 
Sbjct: 90  LLKCG--VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAG 147

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIST 251
              +  + + LQ G +  C+        D  G  PL  A   G ++ V+  L  GA +  
Sbjct: 148 RGHADIVHLLLQNGAKVNCS--------DKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 199

Query: 252 QQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN 311
           +  +  T + +A   G    VK +    P      LT  D    T +  A+   H EIV 
Sbjct: 200 EGANSMTALIVAVKGGYTQSVKEILKRNPNVN---LTDKDGN--TALMIASKEGHTEIVQ 254

Query: 312 YLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            L++ G+ +N  D+   + L+ A        V  L++  ADI ++  +++  L+  V  G
Sbjct: 255 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 314

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
                 A   +D  + +    +  KD  G +PL  A++  +I  +E L+  GA ++  + 
Sbjct: 315 N-----ATMVRDILQCNPDTEICTKD--GETPLIKATKMRNIEVVELLLDKGAKVSAVDK 367

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
             ++PLH A R      A  LL + K   ++   +  G TP +I
Sbjct: 368 KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 411



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 84/345 (24%), Positives = 148/345 (42%), Gaps = 24/345 (6%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G  PL  A   G+++ V+  +++GA  + +  D  T +  A  +G + IV+ +       
Sbjct: 38  GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS-PLLLAASRAGWR 341
           +H      D+   T +  A      ++V  L++ G++ +    +    P++ AA R    
Sbjct: 98  EHR-----DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHAD 152

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGC 401
            VH L++ GA +   D      L +     G LE         C K LL +  + D  G 
Sbjct: 153 IVHLLLQNGAKVNCSDKYGTTPL-VWAARKGHLE---------CVKHLLAMGADVDQEGA 202

Query: 402 SP---LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
           +    L  A + G+ +S++ +++    +NL + +  + L  A++ G       LLD+  G
Sbjct: 203 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA--G 260

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI 517
           T++ N  D  G T L  A R GH  +V  LL + A +  R  + +  L+ A   G    +
Sbjct: 261 TYV-NIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 319

Query: 518 ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
             +   +    +   KDG T L  AT       + LLL  G ++S
Sbjct: 320 RDILQCNPDT-EICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 363



 Score = 69.7 bits (163), Expect = 6e-11
 Identities = 69/248 (27%), Positives = 120/248 (48%), Gaps = 13/248 (5%)

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L+ +  D++  ++  ++PL++AA +     V  LI+ GA+  L+D+++   L +     G
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL-ISASKEG 82

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKN-N 431
            +       K  C  +    L  +D  G + L +A  +G    +E L+  GA  ++    
Sbjct: 83  HVHIVEELLK--CGVN----LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQ 136

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
            +  P+ +AA  GR H     L    G   +N SD  G TPL  A+R+GH   V  LL  
Sbjct: 137 YSVYPIIWAA--GRGHADIVHLLLQNGA-KVNCSDKYGTTPLVWAARKGHLECVKHLLAM 193

Query: 492 GALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GA + ++  N    L +A   GYT++++ +   + + ++  DKDGNT+L +A+ E     
Sbjct: 194 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGHTEI 252

Query: 551 IALLLSMG 558
           +  LL  G
Sbjct: 253 VQDLLDAG 260



 Score = 56.4 bits (130), Expect = 6e-07
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 7/186 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           ++E++  G +PL  A+ +G++  ++ LI+ GA  NL++ +N + L  A++ G  H   +L
Sbjct: 31  VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA--LLHRDHNGRNPLHLAAM 510
           L   K    +   D  G T L  A  +G T VV LLL+ GA   +        P+  AA 
Sbjct: 91  L---KCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAG 147

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MS 569
            G+   + LL   +   ++  DK G T L  A  +     +  LL+MG  +     + M+
Sbjct: 148 RGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMT 206

Query: 570 AIDYAI 575
           A+  A+
Sbjct: 207 ALIVAV 212



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/254 (22%), Positives = 95/254 (37%), Gaps = 29/254 (11%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+ R + +I+H +      +N  D  G TPL  A     L+ +++LL    +        
Sbjct: 145 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 204

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
              + +A +      ++   K     NVN   + G TAL  A+   H    + L+ D   
Sbjct: 205 MTALIVAVKGGYTQSVKEILKRNP--NVNLTDKDGNTALMIASKEGHTEIVQDLL-DAGT 261

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQ-----------------WGEQRG---CTRE 213
               P  +G   +  A +      +   LQ                 W  ++G     R+
Sbjct: 262 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 321

Query: 214 QMISLYDNE-----GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
            +    D E     G  PL  A    +I+ VEL L  GAK+S       TP+H+A    +
Sbjct: 322 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 381

Query: 269 LDIVKLMFTMQPKE 282
             + +L+    PK+
Sbjct: 382 RKLAELLL-RNPKD 394



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 1/103 (0%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + A   G+V+  +R  L + + + +R    +TA + A  + N  ++  I     D     
Sbjct: 275 IGAVRGGHVE-IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT 333

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
             G TPL  A +   ++ +E LL +  + S +++K   P+H+A
Sbjct: 334 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 376



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 37/191 (19%), Positives = 80/191 (41%), Gaps = 4/191 (2%)

Query: 13  NLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD 72
           +++  + A + G       +    P+ + + D  G TA   AS   +T I+  + +    
Sbjct: 204 SMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 262

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N  D +G+T L  AV    ++ +  LLQ++ +  +  +  +  ++ A E    ++++  
Sbjct: 263 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 322

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            +     +     + G T L   A    ++    L+ D  A+       G  P+H A + 
Sbjct: 323 LQCNP--DTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 379

Query: 193 ASSRTIEVFLQ 203
            S +  E+ L+
Sbjct: 380 RSRKLAELLLR 390


>BC043394-1|AAH43394.1|  751|Homo sapiens ANKRD17 protein protein.
          Length = 751

 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 125/500 (25%), Positives = 202/500 (40%), Gaps = 34/500 (6%)

Query: 78  NAG---NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           NAG   N  L  A     ++A+  LL +    +   E+ ++ + +A       + QV   
Sbjct: 229 NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288

Query: 135 YKSLFNVNQGGEHGR-TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
             +  NV   G  G  T L  AA   H    K+L+    A+     + G   +  A    
Sbjct: 289 MHA--NVEDRGIKGDITPLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGG 345

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
               ++V L+ G          I  ++  G+ PL  A   G ++   L L +GA I+T  
Sbjct: 346 YVDVVKVLLESGAS--------IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397

Query: 254 HDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
           ++   + + LAC +G L++V+ +      ++H      D +  T +  A M  H E+   
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEH----KTD-EMHTALMEACMDGHVEVARL 452

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ G+ +N       SPL LAA          LI  GA   L+++N      L+     
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS--LEEVNDEGYTPLMEAARE 510

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
             E+  A           Q     + T  + L  A   G +   + LI+ GA I L    
Sbjct: 511 GHEEMVALLLGQGANINAQT----EETQETALTLACCGGFLEVADFLIKAGADIEL---G 563

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PL  AA+ G       LL +      ++ +   G T L  A   GHT V  +LL  G
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGAN---VHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A L H    GR PL  AA +G+  T++ L S  +++      + +T L LA      + +
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680

Query: 552 ALLLSMGCRLSYNNMDMSAI 571
            LLL+ G   ++   D S +
Sbjct: 681 ELLLAHGADPTHRLKDGSTM 700



 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 102/437 (23%), Positives = 175/437 (40%), Gaps = 26/437 (5%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+   +  I+  +  +  D+NA+ + GNT L  A     +D ++ LL+        NE  
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
             P+  A     V V ++  +  +  N +   E   +AL  A    H    + L+ +  A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLL-EAGA 425

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           + +   +  +  + EA  +       + L  G Q        +++  +    PL  A  G
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAACG 477

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A        
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG-QGANINAQTEETQET 536

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
            +T   C       E+ ++LI  G+DI   +    +PL+ AA       V  L+  GA++
Sbjct: 537 ALTLACCGGFL---EVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANV 590

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
                     L     NG    D A    D   ++   L +E +  G +PL  A+R GH+
Sbjct: 591 HATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAARAGHV 643

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            +++ LI  GA +N    NN+  +   A  G      +LL +          DG   T L
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS--TML 701

Query: 474 HIASREGHTRVVHLLLN 490
             A++ GHT VV  LL+
Sbjct: 702 IEAAKGGHTSVVCYLLD 718



 Score = 71.7 bits (168), Expect = 1e-11
 Identities = 100/464 (21%), Positives = 182/464 (39%), Gaps = 28/464 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K +++  + AA  G+V   ++L L+  + +  +   G TA   A A    +++  +    
Sbjct: 299 KGDITPLMAAANGGHVK-IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVL 129
             +   +  G+TPL  A     ++    LL+     +   NE  ++ + +A     + ++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
           +   +  +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  A
Sbjct: 418 RFLLEAGA--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLA 474

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A         + +    +RG + E++    ++EG  PL  A   G  + V L L  GA I
Sbjct: 475 ACGGHVELAALLI----ERGASLEEV----NDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 250 STQQHDL-STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           + Q  +   T + LAC  G L++   +       +  C         TP+  AA   H E
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--------STPLMEAAQEGHLE 578

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +V YL+  G++++       + L  A           L++ GAD++ +    R  L    
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL---- 634

Query: 369 MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           M   R      + +    K    +     N   + L  A   GH+  +E L+  GA    
Sbjct: 635 MKAAR-AGHVCTVQFLISKG-ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTH 692

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           +  +  + L  AA+ G     C LLD           D   LTP
Sbjct: 693 RLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 736


>BC007747-1|AAH07747.2|  830|Homo sapiens ANKRD17 protein protein.
          Length = 830

 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 125/500 (25%), Positives = 202/500 (40%), Gaps = 34/500 (6%)

Query: 78  NAG---NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
           NAG   N  L  A     ++A+  LL +    +   E+ ++ + +A       + QV   
Sbjct: 49  NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 108

Query: 135 YKSLFNVNQGGEHGR-TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
             +  NV   G  G  T L  AA   H    K+L+    A+     + G   +  A    
Sbjct: 109 MHA--NVEDRGIKGDITPLMAAANGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGG 165

Query: 194 SSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
               ++V L+ G          I  ++  G+ PL  A   G ++   L L +GA I+T  
Sbjct: 166 YVDVVKVLLESGAS--------IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 217

Query: 254 HDLS-TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
           ++   + + LAC +G L++V+ +      ++H      D +  T +  A M  H E+   
Sbjct: 218 NEFKESALTLACYKGHLEMVRFLLEAGADQEH----KTD-EMHTALMEACMDGHVEVARL 272

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
           L++ G+ +N       SPL LAA          LI  GA   L+++N      L+     
Sbjct: 273 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS--LEEVNDEGYTPLMEAARE 330

Query: 373 RLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
             E+  A           Q     + T  + L  A   G +   + LI+ GA I L    
Sbjct: 331 GHEEMVALLLGQGANINAQT----EETQETALTLACCGGFLEVADFLIKAGADIEL---G 383

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PL  AA+ G       LL +      ++ +   G T L  A   GHT V  +LL  G
Sbjct: 384 CSTPLMEAAQEGHLELVKYLLAAGAN---VHATTATGDTALTYACENGHTDVADVLLQAG 440

Query: 493 A-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSI 551
           A L H    GR PL  AA +G+  T++ L S  +++      + +T L LA      + +
Sbjct: 441 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 500

Query: 552 ALLLSMGCRLSYNNMDMSAI 571
            LLL+ G   ++   D S +
Sbjct: 501 ELLLAHGADPTHRLKDGSTM 520



 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 102/437 (23%), Positives = 175/437 (40%), Gaps = 26/437 (5%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           A+   +  I+  +  +  D+NA+ + GNT L  A     +D ++ LL+        NE  
Sbjct: 128 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 187

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDA 173
             P+  A     V V ++  +  +  N +   E   +AL  A    H    + L+ +  A
Sbjct: 188 HTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLL-EAGA 245

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           + +   +  +  + EA  +       + L  G Q        +++  +    PL  A  G
Sbjct: 246 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAACG 297

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQ 293
           G ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A        
Sbjct: 298 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG-QGANINAQTEETQET 356

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
            +T   C       E+ ++LI  G+DI   +    +PL+ AA       V  L+  GA++
Sbjct: 357 ALTLACCGGFL---EVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANV 410

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
                     L     NG    D A    D   ++   L +E +  G +PL  A+R GH+
Sbjct: 411 HATTATGDTALTYACENGH--TDVA----DVLLQAGADLEHESEG-GRTPLMKAARAGHV 463

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
            +++ LI  GA +N    NN+  +   A  G      +LL +          DG   T L
Sbjct: 464 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGS--TML 521

Query: 474 HIASREGHTRVVHLLLN 490
             A++ GHT VV  LL+
Sbjct: 522 IEAAKGGHTSVVCYLLD 538



 Score = 71.7 bits (168), Expect = 1e-11
 Identities = 100/464 (21%), Positives = 182/464 (39%), Gaps = 28/464 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           K +++  + AA  G+V   ++L L+  + +  +   G TA   A A    +++  +    
Sbjct: 119 KGDITPLMAAANGGHVK-IVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 177

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVL 129
             +   +  G+TPL  A     ++    LL+     +   NE  ++ + +A     + ++
Sbjct: 178 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 237

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
           +   +  +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  A
Sbjct: 238 RFLLEAGA--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLA 294

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI 249
           A         + +    +RG + E++    ++EG  PL  A   G  + V L L  GA I
Sbjct: 295 ACGGHVELAALLI----ERGASLEEV----NDEGYTPLMEAAREGHEEMVALLLGQGANI 346

Query: 250 STQQHDL-STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
           + Q  +   T + LAC  G L++   +       +  C         TP+  AA   H E
Sbjct: 347 NAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--------STPLMEAAQEGHLE 398

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV 368
           +V YL+  G++++       + L  A           L++ GAD++ +    R  L    
Sbjct: 399 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL---- 454

Query: 369 MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           M   R      + +    K    +     N   + L  A   GH+  +E L+  GA    
Sbjct: 455 MKAAR-AGHVCTVQFLISKG-ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTH 512

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
           +  +  + L  AA+ G     C LLD           D   LTP
Sbjct: 513 RLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 556


>AL159174-1|CAI39609.1|  692|Homo sapiens ankyrin repeat domain 6
           protein.
          Length = 692

 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 80/279 (28%), Positives = 129/279 (46%), Gaps = 14/279 (5%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA     E V  LIN+G+ +  + K  R+PL LAA++     V  L++ G D+ ++D   
Sbjct: 17  AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75

Query: 361 RNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLI 420
           +  LH   +  G  E  AA   + C       L+ +D  G + LH AS  G  +S + LI
Sbjct: 76  QTALHRATV-VGNTEIIAALIHEGC------ALDRQDKDGNTALHEASWHGFSQSAKLLI 128

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           + GA +  KN    + LH A +     +   LL +     + N +   G T LH+A+R  
Sbjct: 129 KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAARYN 185

Query: 481 HTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           H  ++ LLL     +H ++  G   LH+AA   + K  ++L    +     ++  G T L
Sbjct: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPL 244

Query: 540 HLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
             A   N P  +ALLL+   + S +  D  + + A+  K
Sbjct: 245 ETARYHNNP-EVALLLTKAPQGSVSAGDTPSSEQAVARK 282



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 14/263 (5%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           LL+AA +     V  LI  GA + +   + R  LHL   N G L       K  C+   L
Sbjct: 14  LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAA-NKGHLPVVQILLKAGCD---L 68

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
            + ++ D T    LH A+  G+   +  LI  G  ++ ++ +  + LH A+ +G   +A 
Sbjct: 69  DVQDDGDQTA---LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAA 509
            L+ +       N++   G T LH+A +  H++   +LL  G+     +N G   LH+AA
Sbjct: 126 LLIKAGANVLAKNKA---GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA 182

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDM 568
              +   I LL +    + ++ ++ G+T+LH+A   N      +LL  G   +  NN   
Sbjct: 183 RYNHLSIIRLLLTAFCSVHEK-NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQ 241

Query: 569 SAIDYAIYYKFPEAALAMVTHEQ 591
           + ++ A Y+  PE AL +    Q
Sbjct: 242 TPLETARYHNNPEVALLLTKAPQ 264



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 62/214 (28%), Positives = 95/214 (44%), Gaps = 11/214 (5%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA   H  +V  L+  G D++  D   ++ L  A        +  LI  G  +  
Sbjct: 44  TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +D +    LH    +G     F+ S K   +     L   K+  G + LH A +  H +S
Sbjct: 104 QDKDGNTALHEASWHG-----FSQSAKLLIKAGANVLA--KNKAGNTALHLACQNSHSQS 156

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
              L+  G+  +LKNN  ++ LH AARY        LL +      ++E +  G T LH+
Sbjct: 157 TRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA---FCSVHEKNQAGDTALHV 213

Query: 476 ASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLA 508
           A+   H +V  +LL  GA     +N G+ PL  A
Sbjct: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 65/257 (25%), Positives = 112/257 (43%), Gaps = 34/257 (13%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC-LT 288
           A + G  + V   +  GA+++  +H   TP+HLA  +G L +V+++       K  C L 
Sbjct: 17  AAYKGQTENVVQLINKGARVAVTKHG-RTPLHLAANKGHLPVVQILL------KAGCDLD 69

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
             D    T +H A +  + EI+  LI+EG  ++  DK+  + L  A+     ++   LI+
Sbjct: 70  VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIK 129

Query: 349 LGADIQLKDINSRNVLHLVVMNG-----------GRLEDFAASCKDHC--------EKSL 389
            GA++  K+      LHL   N            G   D   +  D C          S+
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSI 189

Query: 390 LQLL-------NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
           ++LL       +EK+  G + LH A+   H +  + L+  GA   + NN  ++PL  A  
Sbjct: 190 IRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARY 249

Query: 443 YGRFHTACQLLDSDKGT 459
           +     A  L  + +G+
Sbjct: 250 HNNPEVALLLTKAPQGS 266



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 66/276 (23%), Positives = 113/276 (40%), Gaps = 21/276 (7%)

Query: 34  LSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEAL 93
           +S+   +A    R   AA++    N   ++  IN   G   A    G TPLH+A     L
Sbjct: 1   MSQQDAVAALSERLLVAAYKGQTEN---VVQLINK--GARVAVTKHGRTPLHLAANKGHL 55

Query: 94  DAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALH 153
             ++ LL+   +  V ++  Q  +H AT +    +  + A       +++  + G TALH
Sbjct: 56  PVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEI--IAALIHEGCALDRQDKDGNTALH 113

Query: 154 FAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTRE 213
            A+ H     AK+LI    A        G   +H A +N+ S++  V L  G +      
Sbjct: 114 EASWHGFSQSAKLLI-KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR------ 166

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
               L +N G+  LH A     +  + L L +   +  +     T +H+A A     + K
Sbjct: 167 --ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           ++      E  A  T  +    TP+  A   ++PE+
Sbjct: 225 ILL-----EAGADTTIVNNAGQTPLETARYHNNPEV 255



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 4/171 (2%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A   GN +    L + E   L  +D  G TA H+AS    +     +     ++ AK+ 
Sbjct: 81  RATVVGNTEIIAAL-IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNK 139

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           AGNT LH+A +N    +   LL       + N      +H+A   N +S++++     + 
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL--LTAF 197

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            +V++  + G TALH AA  +H   AKIL+ +  A+     N G  P+  A
Sbjct: 198 CSVHEKNQAGDTALHVAAALNHKKVAKILL-EAGADTTIVNNAGQTPLETA 247



 Score = 53.2 bits (122), Expect = 5e-06
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
           +HGRT LH AA   H    +IL+    DLD +     +     +H A    ++  I   +
Sbjct: 40  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ----DDGDQTALHRATVVGNTEIIAALI 95

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                 GC  ++     D +GN  LH A   G  ++ +L +++GA +  +    +T +HL
Sbjct: 96  H----EGCALDRQ----DKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHL 147

Query: 263 ACAQGALDIVKLMFTMQPKE--KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           AC        +++     +   K+    +C       +H AA ++H  I+  L+     +
Sbjct: 148 ACQNSHSQSTRVLLLAGSRADLKNNAGDTC-------LHVAARYNHLSIIRLLLTAFCSV 200

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +  ++   + L +AA+    +    L+  GAD
Sbjct: 201 HEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 49/211 (23%), Positives = 92/211 (43%), Gaps = 12/211 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G++   +++ L     L V+D   +TA H+A+   NT I+  + +    L+ +D  
Sbjct: 49  AANKGHLP-VVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD 107

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           GNT LH A  +    + + L++        N+     +H+A + +     +V     S  
Sbjct: 108 GNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           ++      G T LH AA ++H    ++L+T   +  +K    G   +H AA     +  +
Sbjct: 168 DLKNNA--GDTCLHVAARYNHLSIIRLLLTAFCSVHEKN-QAGDTALHVAAALNHKKVAK 224

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
           + L+ G           ++ +N G  PL +A
Sbjct: 225 ILLEAGAD--------TTIVNNAGQTPLETA 247



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 28/104 (26%), Positives = 49/104 (47%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           R+ L   SR  +++  G T  H A+  N+ +I+  +      ++ K+ AG+T LHVA   
Sbjct: 158 RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAAL 217

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
                 + LL+   +T+++N   Q P+  A   N   V  +  K
Sbjct: 218 NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261


>AL096678-2|CAI42280.1|  692|Homo sapiens ankyrin repeat domain 6
           protein.
          Length = 692

 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 80/279 (28%), Positives = 129/279 (46%), Gaps = 14/279 (5%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA     E V  LIN+G+ +  + K  R+PL LAA++     V  L++ G D+ ++D   
Sbjct: 17  AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75

Query: 361 RNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLI 420
           +  LH   +  G  E  AA   + C       L+ +D  G + LH AS  G  +S + LI
Sbjct: 76  QTALHRATV-VGNTEIIAALIHEGC------ALDRQDKDGNTALHEASWHGFSQSAKLLI 128

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           + GA +  KN    + LH A +     +   LL +     + N +   G T LH+A+R  
Sbjct: 129 KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAARYN 185

Query: 481 HTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           H  ++ LLL     +H ++  G   LH+AA   + K  ++L    +     ++  G T L
Sbjct: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPL 244

Query: 540 HLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
             A   N P  +ALLL+   + S +  D  + + A+  K
Sbjct: 245 ETARYHNNP-EVALLLTKAPQGSVSAGDTPSSEQAVARK 282



 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 14/263 (5%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           LL+AA +     V  LI  GA + +   + R  LHL   N G L       K  C+   L
Sbjct: 14  LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAA-NKGHLPVVQILLKAGCD---L 68

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
            + ++ D T    LH A+  G+   +  LI  G  ++ ++ +  + LH A+ +G   +A 
Sbjct: 69  DVQDDGDQTA---LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAA 509
            L+ +       N++   G T LH+A +  H++   +LL  G+     +N G   LH+AA
Sbjct: 126 LLIKAGANVLAKNKA---GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA 182

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDM 568
              +   I LL +    + ++ ++ G+T+LH+A   N      +LL  G   +  NN   
Sbjct: 183 RYNHLSIIRLLLTAFCSVHEK-NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQ 241

Query: 569 SAIDYAIYYKFPEAALAMVTHEQ 591
           + ++ A Y+  PE AL +    Q
Sbjct: 242 TPLETARYHNNPEVALLLTKAPQ 264



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 62/214 (28%), Positives = 95/214 (44%), Gaps = 11/214 (5%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA   H  +V  L+  G D++  D   ++ L  A        +  LI  G  +  
Sbjct: 44  TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +D +    LH    +G     F+ S K   +     L   K+  G + LH A +  H +S
Sbjct: 104 QDKDGNTALHEASWHG-----FSQSAKLLIKAGANVLA--KNKAGNTALHLACQNSHSQS 156

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
              L+  G+  +LKNN  ++ LH AARY        LL +      ++E +  G T LH+
Sbjct: 157 TRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA---FCSVHEKNQAGDTALHV 213

Query: 476 ASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLA 508
           A+   H +V  +LL  GA     +N G+ PL  A
Sbjct: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 65/257 (25%), Positives = 112/257 (43%), Gaps = 34/257 (13%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC-LT 288
           A + G  + V   +  GA+++  +H   TP+HLA  +G L +V+++       K  C L 
Sbjct: 17  AAYKGQTENVVQLINKGARVAVTKHG-RTPLHLAANKGHLPVVQILL------KAGCDLD 69

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
             D    T +H A +  + EI+  LI+EG  ++  DK+  + L  A+     ++   LI+
Sbjct: 70  VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIK 129

Query: 349 LGADIQLKDINSRNVLHLVVMNG-----------GRLEDFAASCKDHC--------EKSL 389
            GA++  K+      LHL   N            G   D   +  D C          S+
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSI 189

Query: 390 LQLL-------NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
           ++LL       +EK+  G + LH A+   H +  + L+  GA   + NN  ++PL  A  
Sbjct: 190 IRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARY 249

Query: 443 YGRFHTACQLLDSDKGT 459
           +     A  L  + +G+
Sbjct: 250 HNNPEVALLLTKAPQGS 266



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 66/276 (23%), Positives = 113/276 (40%), Gaps = 21/276 (7%)

Query: 34  LSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEAL 93
           +S+   +A    R   AA++    N   ++  IN   G   A    G TPLH+A     L
Sbjct: 1   MSQQDAVAALSERLLVAAYKGQTEN---VVQLINK--GARVAVTKHGRTPLHLAANKGHL 55

Query: 94  DAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALH 153
             ++ LL+   +  V ++  Q  +H AT +    +  + A       +++  + G TALH
Sbjct: 56  PVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEI--IAALIHEGCALDRQDKDGNTALH 113

Query: 154 FAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTRE 213
            A+ H     AK+LI    A        G   +H A +N+ S++  V L  G +      
Sbjct: 114 EASWHGFSQSAKLLI-KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR------ 166

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
               L +N G+  LH A     +  + L L +   +  +     T +H+A A     + K
Sbjct: 167 --ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           ++      E  A  T  +    TP+  A   ++PE+
Sbjct: 225 ILL-----EAGADTTIVNNAGQTPLETARYHNNPEV 255



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 4/171 (2%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A   GN +    L + E   L  +D  G TA H+AS    +     +     ++ AK+ 
Sbjct: 81  RATVVGNTEIIAAL-IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNK 139

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           AGNT LH+A +N    +   LL       + N      +H+A   N +S++++     + 
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL--LTAF 197

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            +V++  + G TALH AA  +H   AKIL+ +  A+     N G  P+  A
Sbjct: 198 CSVHEKNQAGDTALHVAAALNHKKVAKILL-EAGADTTIVNNAGQTPLETA 247



 Score = 53.2 bits (122), Expect = 5e-06
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
           +HGRT LH AA   H    +IL+    DLD +     +     +H A    ++  I   +
Sbjct: 40  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ----DDGDQTALHRATVVGNTEIIAALI 95

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                 GC  ++     D +GN  LH A   G  ++ +L +++GA +  +    +T +HL
Sbjct: 96  H----EGCALDRQ----DKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHL 147

Query: 263 ACAQGALDIVKLMFTMQPKE--KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           AC        +++     +   K+    +C       +H AA ++H  I+  L+     +
Sbjct: 148 ACQNSHSQSTRVLLLAGSRADLKNNAGDTC-------LHVAARYNHLSIIRLLLTAFCSV 200

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +  ++   + L +AA+    +    L+  GAD
Sbjct: 201 HEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 49/211 (23%), Positives = 92/211 (43%), Gaps = 12/211 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G++   +++ L     L V+D   +TA H+A+   NT I+  + +    L+ +D  
Sbjct: 49  AANKGHLP-VVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD 107

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           GNT LH A  +    + + L++        N+     +H+A + +     +V     S  
Sbjct: 108 GNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           ++      G T LH AA ++H    ++L+T   +  +K    G   +H AA     +  +
Sbjct: 168 DLKNNA--GDTCLHVAARYNHLSIIRLLLTAFCSVHEKN-QAGDTALHVAAALNHKKVAK 224

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
           + L+ G           ++ +N G  PL +A
Sbjct: 225 ILLEAGAD--------TTIVNNAGQTPLETA 247



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 28/104 (26%), Positives = 49/104 (47%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           R+ L   SR  +++  G T  H A+  N+ +I+  +      ++ K+ AG+T LHVA   
Sbjct: 158 RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAAL 217

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
                 + LL+   +T+++N   Q P+  A   N   V  +  K
Sbjct: 218 NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261


>AF451977-1|AAL49758.1| 1431|Homo sapiens cask-interacting protein 1
           protein.
          Length = 1431

 Score = 93.5 bits (222), Expect = 4e-18
 Identities = 67/221 (30%), Positives = 105/221 (47%), Gaps = 15/221 (6%)

Query: 396 KDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           KDN G  PLHYA+ +G    ++ +++ G+ +N+ ++    PLH AA++G +  +  LL  
Sbjct: 78  KDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQH 137

Query: 456 DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR---GALLH------RDHNGRNPLH 506
                ++   D  G TPL +A   G   VV LLL+     ALL        D NG +PLH
Sbjct: 138 QSNPCMV---DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLH 194

Query: 507 LAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NN 565
           LAA +G+   I LL      +  Q  K G T+LH A +  K   + LLL  G      N 
Sbjct: 195 LAAKNGHIDIIRLLLQAGIDINRQ-TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNT 252

Query: 566 MDMSAIDYAIYYKFPEAALAMVTHEQRAKEVMALRSDRHPC 606
              +A+D    +   +A+  +    + A   + +R+ +  C
Sbjct: 253 YSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293



 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 59/190 (31%), Positives = 92/190 (48%), Gaps = 11/190 (5%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N +D  G S LH+A+  G+   +  L+   A +++K+N    PLH+AA  GR      +
Sbjct: 42  VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLV 101

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL-NRGALLHRDHNGRNPLHLAAMS 511
           L   K    +N    EG  PLH+A++ GH  V  +LL ++      D++G+ PL LA   
Sbjct: 102 L---KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEF 158

Query: 512 GYTKTIELLHSVH--SHLL-----DQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           G    ++LL S +  + LL     D  D +G + LHLA        I LLL  G  ++  
Sbjct: 159 GRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218

Query: 565 NMDMSAIDYA 574
               +A+  A
Sbjct: 219 TKSGTALHEA 228



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 60/235 (25%), Positives = 104/235 (44%), Gaps = 21/235 (8%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           NVN     G +ALH AA++ +     +L+ +  A      N G  P+H AA       ++
Sbjct: 41  NVNFQDPDGFSALHHAALNGNTELISLLL-EAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           + L+ G          +++  +EG++PLH A   G     E+ L+  +      +   TP
Sbjct: 100 LVLKAGSA--------VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTP 151

Query: 260 VHLACAQGALDIVKLMFT-------MQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNY 312
           + LAC  G + +V+L+ +       ++P+   A     D    +P+H AA   H +I+  
Sbjct: 152 LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDAT----DPNGTSPLHLAAKNGHIDIIRL 207

Query: 313 LINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           L+  G DIN   K   + L  AA       V  L+  G +  +++  S+  L +V
Sbjct: 208 LLQAGIDINRQTKS-GTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIV 261



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 10/207 (4%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
           ++N +D  G + LH A  N   + I  LL+      + + K   P+H A    +   +++
Sbjct: 41  NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100

Query: 132 FAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPC---NNGYYPIHE 188
             K  S  N+    + G   LH AA H H   +++L+         PC   N+G  P+  
Sbjct: 101 VLKAGSAVNI--PSDEGHIPLHLAAQHGHYDVSEMLL----QHQSNPCMVDNSGKTPLDL 154

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A +      +++ L           +     D  G  PLH A   G I  + L L++G  
Sbjct: 155 ACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGID 214

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLM 275
           I+ Q     T +H A   G  ++V+L+
Sbjct: 215 INRQTKS-GTALHEAALCGKTEVVRLL 240



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 45/193 (23%), Positives = 85/193 (44%), Gaps = 11/193 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +GN +  + L L   + + ++D +G    H A+ +     +  +      +N   + 
Sbjct: 56  AALNGNTE-LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDE 114

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK--- 136
           G+ PLH+A ++   D  E LLQ      +++   + P+ +A E  +V V+Q+        
Sbjct: 115 GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCA 174

Query: 137 SLFNVNQG---GEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
           +L     G     +G + LH AA + H D+   +L   +D    +   +G   +HEAA  
Sbjct: 175 ALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDI--NRQTKSG-TALHEAALC 231

Query: 193 ASSRTIEVFLQWG 205
             +  + + L  G
Sbjct: 232 GKTEVVRLLLDSG 244



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 61/244 (25%), Positives = 102/244 (41%), Gaps = 27/244 (11%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +A H A+   NT ++  +      ++ KDN G  PLH A      + ++ +L+ 
Sbjct: 45  QDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKA 104

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
               ++ +++   P+H+A +     V ++  +++S  N       G+T L  A       
Sbjct: 105 GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQS--NPCMVDNSGKTPLDLACEFGRVG 162

Query: 163 CAKILI-TDLDAEWKKP------CNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQM 215
             ++L+ +++ A   +P        NG  P+H AAKN     I + LQ G          
Sbjct: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGID-------- 214

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           I+     G   LH A   G  + V L L SG         ++  V    +Q ALDIV   
Sbjct: 215 INRQTKSGTA-LHEAALCGKTEVVRLLLDSG---------INAHVRNTYSQTALDIVHQF 264

Query: 276 FTMQ 279
            T Q
Sbjct: 265 TTSQ 268



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 43/171 (25%), Positives = 70/171 (40%), Gaps = 13/171 (7%)

Query: 209 GCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
           G T++  ++  D +G   LH A   G+ + + L L + A +  + +    P+H A  QG 
Sbjct: 35  GSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGR 94

Query: 269 LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR 328
            + +KL+     K   A     D +   P+H AA   H ++   L+   S+   +D   +
Sbjct: 95  KEPMKLVL----KAGSAVNIPSD-EGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQL--------KDINSRNVLHLVVMNG 371
           +PL LA        V  L+       L         D N  + LHL   NG
Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNG 200


>AB023174-1|BAA76801.2|  693|Homo sapiens KIAA0957 protein protein.
          Length = 693

 Score = 93.1 bits (221), Expect = 5e-18
 Identities = 79/279 (28%), Positives = 129/279 (46%), Gaps = 14/279 (5%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA     E V  LIN+G+ +  + K  R+PL LAA++     V  L++ G D+ ++D   
Sbjct: 18  AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 76

Query: 361 RNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLI 420
           +  LH   +  G  E  AA   + C       L+ +D  G + LH AS  G  +S + L+
Sbjct: 77  QTALHRATV-VGNTEIIAALIHEGC------ALDRQDKDGNTALHEASWHGFSQSAKLLV 129

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           + GA +  KN    + LH A +     +   LL +     + N +   G T LH+A+R  
Sbjct: 130 KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAARYN 186

Query: 481 HTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           H  ++ LLL     +H ++  G   LH+AA   + K  ++L    +     ++  G T L
Sbjct: 187 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPL 245

Query: 540 HLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
             A   N P  +ALLL+   + S +  D  + + A+  K
Sbjct: 246 ETARYHNNP-EVALLLTKAPQGSVSAGDTPSSEQAVARK 283



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 14/263 (5%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           LL+AA +     V  LI  GA + +   + R  LHL   N G L       K  C+   L
Sbjct: 15  LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAA-NKGHLPVVQILLKAGCD---L 69

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
            + ++ D T    LH A+  G+   +  LI  G  ++ ++ +  + LH A+ +G   +A 
Sbjct: 70  DVQDDGDQTA---LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 126

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAA 509
            L+ +       N++   G T LH+A +  H++   +LL  G+     +N G   LH+AA
Sbjct: 127 LLVKAGANVLAKNKA---GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA 183

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDM 568
              +   I LL +    + ++ ++ G+T+LH+A   N      +LL  G   +  NN   
Sbjct: 184 RYNHLSIIRLLLTAFCSVHEK-NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQ 242

Query: 569 SAIDYAIYYKFPEAALAMVTHEQ 591
           + ++ A Y+  PE AL +    Q
Sbjct: 243 TPLETARYHNNPEVALLLTKAPQ 265



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 63/214 (29%), Positives = 97/214 (45%), Gaps = 11/214 (5%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA   H  +V  L+  G D++  D   ++ L  A        +  LI  G  +  
Sbjct: 45  TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 104

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +D +    LH    +G     F+ S K    K+   +L  K+  G + LH A +  H +S
Sbjct: 105 QDKDGNTALHEASWHG-----FSQSAK-LLVKAGANVL-AKNKAGNTALHLACQNSHSQS 157

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
              L+  G+  +LKNN  ++ LH AARY        LL +      ++E +  G T LH+
Sbjct: 158 TRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA---FCSVHEKNQAGDTALHV 214

Query: 476 ASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLA 508
           A+   H +V  +LL  GA     +N G+ PL  A
Sbjct: 215 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 248



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 65/277 (23%), Positives = 114/277 (41%), Gaps = 21/277 (7%)

Query: 33  YLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEA 92
           ++S+   +A    R   AA++    N   ++  IN   G   A    G TPLH+A     
Sbjct: 1   FMSQQDAVAALSERLLVAAYKGQTEN---VVQLINK--GARVAVTKHGRTPLHLAANKGH 55

Query: 93  LDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTAL 152
           L  ++ LL+   +  V ++  Q  +H AT +    +  + A       +++  + G TAL
Sbjct: 56  LPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEI--IAALIHEGCALDRQDKDGNTAL 113

Query: 153 HFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTR 212
           H A+ H     AK+L+    A        G   +H A +N+ S++  V L  G +     
Sbjct: 114 HEASWHGFSQSAKLLV-KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR----- 167

Query: 213 EQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV 272
                L +N G+  LH A     +  + L L +   +  +     T +H+A A     + 
Sbjct: 168 ---ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVA 224

Query: 273 KLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           K++      E  A  T  +    TP+  A   ++PE+
Sbjct: 225 KILL-----EAGADTTIVNNAGQTPLETARYHNNPEV 256



 Score = 66.1 bits (154), Expect = 7e-10
 Identities = 64/257 (24%), Positives = 112/257 (43%), Gaps = 34/257 (13%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC-LT 288
           A + G  + V   +  GA+++  +H   TP+HLA  +G L +V+++       K  C L 
Sbjct: 18  AAYKGQTENVVQLINKGARVAVTKHG-RTPLHLAANKGHLPVVQILL------KAGCDLD 70

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIR 348
             D    T +H A +  + EI+  LI+EG  ++  DK+  + L  A+     ++   L++
Sbjct: 71  VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 130

Query: 349 LGADIQLKDINSRNVLHLVVMNG-----------GRLEDFAASCKDHC--------EKSL 389
            GA++  K+      LHL   N            G   D   +  D C          S+
Sbjct: 131 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSI 190

Query: 390 LQLL-------NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAAR 442
           ++LL       +EK+  G + LH A+   H +  + L+  GA   + NN  ++PL  A  
Sbjct: 191 IRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARY 250

Query: 443 YGRFHTACQLLDSDKGT 459
           +     A  L  + +G+
Sbjct: 251 HNNPEVALLLTKAPQGS 267



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 4/171 (2%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A   GN +    L + E   L  +D  G TA H+AS    +     +     ++ AK+ 
Sbjct: 82  RATVVGNTEIIAAL-IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNK 140

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           AGNT LH+A +N    +   LL       + N      +H+A   N +S++++     + 
Sbjct: 141 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL--LTAF 198

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            +V++  + G TALH AA  +H   AKIL+ +  A+     N G  P+  A
Sbjct: 199 CSVHEKNQAGDTALHVAAALNHKKVAKILL-EAGADTTIVNNAGQTPLETA 248



 Score = 52.8 bits (121), Expect = 7e-06
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
           +HGRT LH AA   H    +IL+    DLD +     +     +H A    ++  I   +
Sbjct: 41  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ----DDGDQTALHRATVVGNTEIIAALI 96

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                 GC  ++     D +GN  LH A   G  ++ +L +++GA +  +    +T +HL
Sbjct: 97  H----EGCALDRQ----DKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHL 148

Query: 263 ACAQGALDIVKLMFTMQPKE--KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           AC        +++     +   K+    +C       +H AA ++H  I+  L+     +
Sbjct: 149 ACQNSHSQSTRVLLLAGSRADLKNNAGDTC-------LHVAARYNHLSIIRLLLTAFCSV 201

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +  ++   + L +AA+    +    L+  GAD
Sbjct: 202 HEKNQAGDTALHVAAALNHKKVAKILLEAGAD 233



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 49/211 (23%), Positives = 92/211 (43%), Gaps = 12/211 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G++   +++ L     L V+D   +TA H+A+   NT I+  + +    L+ +D  
Sbjct: 50  AANKGHLP-VVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD 108

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           GNT LH A  +    + + L++        N+     +H+A + +     +V     S  
Sbjct: 109 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 168

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           ++      G T LH AA ++H    ++L+T   +  +K    G   +H AA     +  +
Sbjct: 169 DLKNNA--GDTCLHVAARYNHLSIIRLLLTAFCSVHEKN-QAGDTALHVAAALNHKKVAK 225

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
           + L+ G           ++ +N G  PL +A
Sbjct: 226 ILLEAGAD--------TTIVNNAGQTPLETA 248



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 28/104 (26%), Positives = 49/104 (47%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           R+ L   SR  +++  G T  H A+  N+ +I+  +      ++ K+ AG+T LHVA   
Sbjct: 159 RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAAL 218

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK 134
                 + LL+   +T+++N   Q P+  A   N   V  +  K
Sbjct: 219 NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 262


>AB046856-1|BAB13462.2| 1864|Homo sapiens KIAA1636 protein protein.
          Length = 1864

 Score = 92.3 bits (219), Expect = 9e-18
 Identities = 99/347 (28%), Positives = 145/347 (41%), Gaps = 32/347 (9%)

Query: 232  HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCD 291
            H G  + V L L  GA +        TP+  A A G L IV L+   + K  H      D
Sbjct: 768  HLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL-----D 822

Query: 292  VQKMTPIHCAAMFDHPEIVNYLIN-----EGSDINPLDKER--RSPLLLAASRAGWRTVH 344
                  +  AA+  H E+V +LI       G       K    +  L+ AAS      V 
Sbjct: 823  KNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVS 882

Query: 345  TLIRLGA----DIQLKDINSRNVLH----LVVMNG-GRLEDFAASCKDHCEKSLLQLLNE 395
             L+ L      +++   INS + L     L    G G+LE     C+   E+     + +
Sbjct: 883  YLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLE----VCRLLLEQGAA--VAQ 936

Query: 396  KDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
             +  G  PL    R+GH + ++ L+  GA +N+ +    +PL  AA  G   T   LL  
Sbjct: 937  PNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ 996

Query: 456  DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYT 514
                 ++   D EGLT L  A  +GH  VV  L++ GA   H D NGR PL LAA  G  
Sbjct: 997  GASIALM---DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDA 1053

Query: 515  KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            + ++ L   H  +++ +D  G   L  A      S +  LL  G ++
Sbjct: 1054 EVVQFLVD-HGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1099



 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 94/350 (26%), Positives = 151/350 (43%), Gaps = 38/350 (10%)

Query: 223  GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM----FTM 278
            G  PL  A   G +  V L  +  AK+     +    +  A  +G L++VK +    +TM
Sbjct: 792  GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 851

Query: 279  QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN---------EGSDINPLDKE-RR 328
              +++     S  +Q+   +  AA   + EIV+YL++         E + IN  D     
Sbjct: 852  AGQQQGVFKKSHAIQQA--LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGE 909

Query: 329  SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEK 387
            + L  AA R        L+  GA +   +      L   V  G  ++ D   +   H   
Sbjct: 910  TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT---HGAD 966

Query: 388  SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
                 +N  D  G +PL  A+ EGH+ +++ L+  GA I L +    + L +A   G   
Sbjct: 967  -----VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLS 1021

Query: 448  TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLH 506
                L+D+   T   + +D  G TPL +A+  G   VV  L++ GA++ H D++G  PL 
Sbjct: 1022 VVRSLVDNGAAT---DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD 1078

Query: 507  LAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
             A   G   T     SV   LL +  K G  +  +AT  +KP  + +LLS
Sbjct: 1079 RAV--GCRNT-----SVVVTLLKKGAKIGPATWAMAT--SKPDIMIILLS 1119



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 84/353 (23%), Positives = 142/353 (40%), Gaps = 19/353 (5%)

Query: 235  DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK 294
            +IK   L +  GA I+ +   L+    + C Q  L   +++  +   E  A + +     
Sbjct: 736  NIKVSRLLILGGANINYRTEVLNN-APILCVQSHLGYTEMVALLL--EFGANVDASSESG 792

Query: 295  MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG---A 351
            +TP+  AA   +  IV  L  + + ++ LDK  +  L+ AA R     V  LI+     A
Sbjct: 793  LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA 852

Query: 352  DIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHCEKSLLQL----LNEKDNT-GCSPL 404
              Q       + +   ++    +   +  +   D  EK   ++    +N  D+  G + L
Sbjct: 853  GQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETAL 912

Query: 405  HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
              A+  G +     L+  GA +   N     PL    R G +     LL        +N 
Sbjct: 913  TAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD---VNM 969

Query: 465  SDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSV 523
            +D +G TPL +A+ EGH   V  LL +GA +   D  G   L  A + G+   +  L   
Sbjct: 970  ADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD- 1028

Query: 524  HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYAI 575
            +    D  DK+G T L LA        +  L+  G  + + +   M  +D A+
Sbjct: 1029 NGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAV 1081



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 16/207 (7%)

Query: 148  GRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGE 206
            G TAL  AA     ++C   L+ +  A   +P   G  P+    +    + +++ L  G 
Sbjct: 908  GETALTAAAGRGKLEVCR--LLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 965

Query: 207  QRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQ 266
                     +++ D +G  PL  A   G +  V+  L  GA I+    +  T +  AC +
Sbjct: 966  D--------VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1017

Query: 267  GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE 326
            G L +V+ +        HA     D    TP+  AA +   E+V +L++ G+ I  +D  
Sbjct: 1018 GHLSVVRSLVDNGAATDHA-----DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS 1072

Query: 327  RRSPLLLAASRAGWRTVHTLIRLGADI 353
               PL  A        V TL++ GA I
Sbjct: 1073 GMRPLDRAVGCRNTSVVVTLLKKGAKI 1099



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 78/313 (24%), Positives = 138/313 (44%), Gaps = 19/313 (6%)

Query: 291  DVQKMTPIHCA-AMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
            +V    PI C  +   + E+V  L+  G++++   +   +PL  AA+      V  L + 
Sbjct: 755  EVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKK 814

Query: 350  GADIQLKDINSRNVL-HLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYAS 408
             A +   D N +  L H  +     +  F   C D       Q + +K +     L  A+
Sbjct: 815  RAKVDHLDKNGQCALVHAALRGHLEVVKFLIQC-DWTMAGQQQGVFKKSHAIQQALIAAA 873

Query: 409  REGHIRSLENLIRLG---------ACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKG 458
              G+   +  L+ L          A IN  ++   E+ L  AA  G+    C+LL  ++G
Sbjct: 874  SMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEV-CRLL-LEQG 931

Query: 459  TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI 517
              +  + +  G  PL    R+GH ++V LLL  GA ++  D  GR PL +AA  G+  T+
Sbjct: 932  AAVA-QPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTV 990

Query: 518  ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD-MSAIDYAIY 576
            + L +  + +   +DK+G T+L  A ++   S +  L+  G    + + +  + +D A +
Sbjct: 991  DFLLAQGASIA-LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAF 1049

Query: 577  YKFPEAALAMVTH 589
            Y   E    +V H
Sbjct: 1050 YGDAEVVQFLVDH 1062



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 5/149 (3%)

Query: 220  DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
            +  G VPL S V  G  + V+L L  GA ++       TP+ +A ++G L  V  +    
Sbjct: 938  NRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLA-- 995

Query: 280  PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
               + A +   D + +T +  A +  H  +V  L++ G+  +  DK  R+PL LAA    
Sbjct: 996  ---QGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGD 1052

Query: 340  WRTVHTLIRLGADIQLKDINSRNVLHLVV 368
               V  L+  GA I+  D +    L   V
Sbjct: 1053 AEVVQFLVDHGAMIEHVDYSGMRPLDRAV 1081



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 40/190 (21%), Positives = 81/190 (42%), Gaps = 4/190 (2%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA  G ++   RL L + + +A  + RG         + +  I+  +  +  D+N  D  
Sbjct: 915  AAGRGKLE-VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 973

Query: 80   GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            G TPL +A     L  +++LL Q    ++++++    +  A     +SV++      +  
Sbjct: 974  GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA- 1032

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
              +   ++GRT L  AA +      + L+ D  A  +    +G  P+  A    ++  + 
Sbjct: 1033 -TDHADKNGRTPLDLAAFYGDAEVVQFLV-DHGAMIEHVDYSGMRPLDRAVGCRNTSVVV 1090

Query: 200  VFLQWGEQRG 209
              L+ G + G
Sbjct: 1091 TLLKKGAKIG 1100



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 46/213 (21%), Positives = 82/213 (38%), Gaps = 13/213 (6%)

Query: 47   GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
            G TA   A+ R    +   +      +   +  G  PL   V       ++ LL    + 
Sbjct: 908  GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 967

Query: 107  SVLNEKCQAPIHMATELNKVSVLQ-VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            ++ +++ + P+ MA     +  +  + A+  S+  ++   + G TAL +A +  H    +
Sbjct: 968  NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMD---KEGLTALSWACLKGHLSVVR 1024

Query: 166  ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
             L+ D  A       NG  P+  AA    +  ++  +  G         MI   D  G  
Sbjct: 1025 SLV-DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG--------AMIEHVDYSGMR 1075

Query: 226  PLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
            PL  AV   +   V   L+ GAKI      ++T
Sbjct: 1076 PLDRAVGCRNTSVVVTLLKKGAKIGPATWAMAT 1108


>AK124559-1|BAC85884.1| 1005|Homo sapiens protein ( Homo sapiens
           cDNA FLJ42568 fis, clone BRACE3007625, moderately
           similar to Rattus norvegicus espin (Espn). ).
          Length = 1005

 Score = 91.9 bits (218), Expect = 1e-17
 Identities = 96/319 (30%), Positives = 141/319 (44%), Gaps = 22/319 (6%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTP-VHLACAQGALDIVKLMFTMQPKEKHACLT 288
           A   GD+  +E  L +GA        L    VH A   G LD VK  F +Q  +      
Sbjct: 9   AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVK--FLVQRAQLPGNQR 66

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVHTLI 347
           + +    TP H AA       + +L+ EG   +   D    SPL LAA       V  L+
Sbjct: 67  AHN--GATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLL 124

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYA 407
             G    L+       LH   ++G        +C      +    +N +  +G SPL+ A
Sbjct: 125 HEGHSATLETREGARPLHHAAVSGD------LTCLKLLTAAHGSSVNRRTRSGASPLYLA 178

Query: 408 SREGHIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTACQLLD-SDKGTFIINES 465
            +EGH+   + L++  GA ++L+  +  S LH AA  G +     L+  +D G   +   
Sbjct: 179 CQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG---LTAR 235

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           D EG T LH A+R GHT ++  LL  G  + RD  G  PLH AA +G    +E   ++ S
Sbjct: 236 DNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENG---QMECCQTLVS 292

Query: 526 HLLDQI--DKDGNTSLHLA 542
           H +D    D+DG T+  LA
Sbjct: 293 HHVDPSLRDEDGYTAADLA 311



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 56/168 (33%), Positives = 82/168 (48%), Gaps = 4/168 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           L ++D +G SPLH A+R GH   +E L+  G    L+      PLH AA  G   T  +L
Sbjct: 97  LQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDL-TCLKL 155

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLAAM 510
           L +  G+ + N     G +PL++A +EGH  +   L+   GA +H R  +G + LH AA 
Sbjct: 156 LTAAHGSSV-NRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAA 214

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
            G+   +  L +     L   D +G T+LH A        +  LL MG
Sbjct: 215 RGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG 262



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 47/151 (31%), Positives = 79/151 (52%), Gaps = 4/151 (2%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACI-NLKNNNNESPLHFAARYGRFHTACQLLDS 455
           D  G   +H+A+R GH+  ++ L++      N + +N  +P H AA  G     C L+  
Sbjct: 33  DALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVR- 91

Query: 456 DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG-ALLHRDHNGRNPLHLAAMSGYT 514
            +G   + + D  G++PLH+A+R GH  +V  LL+ G +       G  PLH AA+SG  
Sbjct: 92  -EGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDL 150

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATME 545
             ++LL + H   +++  + G + L+LA  E
Sbjct: 151 TCLKLLTAAHGSSVNRRTRSGASPLYLACQE 181



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 71/306 (23%), Positives = 117/306 (38%), Gaps = 25/306 (8%)

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G   +H A    H  C K L+        +  +NG  P H+AA   S   +   ++ G  
Sbjct: 36  GAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREG-- 93

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
            GC  +      D  G  PLH A   G    VE  L  G   + +  + + P+H A   G
Sbjct: 94  -GCGLQDQ----DASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSG 148

Query: 268 ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINE-GSDINPLDKE 326
            L  +KL+        +    S      +P++ A    H  +  +L+ + G+D++    +
Sbjct: 149 DLTCLKLLTAAHGSSVNRRTRS----GASPLYLACQEGHLHLAQFLVKDCGADVHLRALD 204

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASCKDH 384
             S L  AA+R  +  V  L+    DI L  +D      LH     G           D 
Sbjct: 205 GMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFAARGG------HTPILDR 257

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 444
                  +L  +D+ G +PLH A+  G +   + L+      +L++ +  +    A  +G
Sbjct: 258 LLLMGTPIL--RDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHG 315

Query: 445 RFHTAC 450
             H  C
Sbjct: 316 --HRDC 319



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 55/257 (21%), Positives = 97/257 (37%), Gaps = 11/257 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G++ +   L       L  +D  G +  H A+   +  ++ ++ +       +   
Sbjct: 77  AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQVFAKYKSL 138
           G  PLH A  +  L  ++ L   H  +     +  A P+++A +   + + Q   K    
Sbjct: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
            +V+     G +ALH AA   H      L+T  D       N G   +H AA+   +  +
Sbjct: 197 -DVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPIL 255

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
           +  L  G            L D+ G  PLH A   G ++  +  +      S +  D  T
Sbjct: 256 DRLLLMGTP---------ILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306

Query: 259 PVHLACAQGALDIVKLM 275
              LA   G  D  + +
Sbjct: 307 AADLAEYHGHRDCAQYL 323


>AF159164-1|AAD45345.1|  544|Homo sapiens ankyrin repeat-containing
           protein ASB-2 protein.
          Length = 544

 Score = 91.9 bits (218), Expect = 1e-17
 Identities = 87/341 (25%), Positives = 153/341 (44%), Gaps = 23/341 (6%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PL  A+  GD +A++  ++ G  ++    +   P+H A   G +  +K++    P     
Sbjct: 19  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP----G 74

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            +    +Q+ T ++ A    H + +  L+  G++ +  +K R +PL  A  R     V  
Sbjct: 75  TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 134

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++  AD   +       LH  V     LE          +        E  N   +PL 
Sbjct: 135 LVQHNADTNHRCNRGWTALHESVSRND-LEVMQILVSGGAKV-------ESKNAYGTPLF 186

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINES 465
            A++ G + +L  L + GA IN + ++N S L+ A +         LL         N++
Sbjct: 187 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADA---NKT 243

Query: 466 DGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHS--- 522
           + +GL PLHIAS++G+ R+V +LL   +      +G +PLHLAA   + + +E L S   
Sbjct: 244 NKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARF 303

Query: 523 -VHSHLLDQ---IDKDGNTS-LHLATMENKPSSIALLLSMG 558
            V++ L  +   + +D  +S L+ A + N   +  LLL  G
Sbjct: 304 DVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG 344



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 79/375 (21%), Positives = 172/375 (45%), Gaps = 24/375 (6%)

Query: 83  PLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAK-YKSLFNV 141
           PL  A+++   +A++ ++++    +  N++   P+H A    +V  L+V  + Y     +
Sbjct: 19  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPG--TI 76

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +Q      TA++ A    H  C   L+    AE      +   P+++A +  ++  +++ 
Sbjct: 77  DQRTLQEETAVYLATCRGHLDCLLSLL-QAGAEPDISNKSRETPLYKACERKNAEAVKIL 135

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           +Q       T  +      N G   LH +V   D++ +++ +  GAK+ ++ +   TP+ 
Sbjct: 136 VQHNAD---TNHRC-----NRGWTALHESVSRNDLEVMQILVSGGAKVESK-NAYGTPLF 186

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           +A   G L+ ++ +      +  A + +      + ++ A   +H E+V +L+++G+D N
Sbjct: 187 VAAQSGQLEALRFL-----AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN 241

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVV-MNGGRLEDFAAS 380
             +K+   PL +A+ +  +R V  L+ + +  +++  +  + LHL    N   + +   S
Sbjct: 242 KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLS 300

Query: 381 CKDHCEKSLL-QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
            +      L  +     ++   S L++A    ++ + E L++ GA     N +  SPL  
Sbjct: 301 ARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLV 357

Query: 440 AARYGRFHTACQLLD 454
           A R+G   T   LLD
Sbjct: 358 AIRHGCLRTMQLLLD 372



 Score = 70.5 bits (165), Expect = 3e-11
 Identities = 68/313 (21%), Positives = 134/313 (42%), Gaps = 23/313 (7%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINN-YAGDLNAK 76
           ++A + G+ ++ ++  + E   LA  +  G    H+A+       L  +   Y G ++ +
Sbjct: 21  IKAIKDGD-EEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 79

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
                T +++A     LD +  LLQ   E  + N+  + P++ A E      +++  ++ 
Sbjct: 80  TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 139

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEAAKNASS 195
           +  + N     G TALH  ++  +DL    ++    A  K    N Y  P+  AA++   
Sbjct: 140 A--DTNHRCNRGWTALH-ESVSRNDLEVMQILVSGGA--KVESKNAYGTPLFVAAQSGQL 194

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
             +    ++G          I+   ++    L+ A      + VE  L  GA  +    D
Sbjct: 195 EALRFLAKYGAD--------INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKD 246

Query: 256 LSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
              P+H+A  +G   IV+++  +  +      T      ++P+H AA  +H E++  L++
Sbjct: 247 GLLPLHIASKKGNYRIVQMLLPVTSR------TRIRRSGVSPLHLAAERNHDEVLEALLS 300

Query: 316 EGSDIN-PLDKER 327
              D+N PL  ER
Sbjct: 301 ARFDVNTPLAPER 313



 Score = 52.4 bits (120), Expect = 9e-06
 Identities = 40/164 (24%), Positives = 71/164 (43%), Gaps = 4/164 (2%)

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           ++ A+  GH+  L +L++ GA  ++ N + E+PL+ A           L+  +  T   N
Sbjct: 87  VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT---N 143

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV 523
                G T LH +       V+ +L++ GA +   +    PL +AA SG  + +  L   
Sbjct: 144 HRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGTPLFVAAQSGQLEALRFLAKY 203

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            + +  Q   D  ++L+ A        +  LLS G   +  N D
Sbjct: 204 GADINTQA-SDNASALYEACKNEHEEVVEFLLSQGADANKTNKD 246



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 17/278 (6%)

Query: 150 TALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRG 209
           T L+ A    +    KIL+   +A+    CN G+  +HE+        +++ +  G    
Sbjct: 118 TPLYKACERKNAEAVKILVQH-NADTNHRCNRGWTALHESVSRNDLEVMQILVSGG---- 172

Query: 210 CTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGAL 269
             + +  + Y      PL  A   G ++A+    + GA I+TQ  D ++ ++ AC     
Sbjct: 173 -AKVESKNAY----GTPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 227

Query: 270 DIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRS 329
           ++V+ + +     + A     +   + P+H A+   +  IV  L+   S    + +   S
Sbjct: 228 EVVEFLLS-----QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR-IRRSGVS 281

Query: 330 PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSL 389
           PL LAA R     +  L+    D+       R  L+        L     +   +  + L
Sbjct: 282 PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY-EDRRSSALYFAVVNNNVYATELL 340

Query: 390 LQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
           LQ   + +    SPL  A R G +R+++ L+  GA I+
Sbjct: 341 LQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 378



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 11/218 (5%)

Query: 377 FAASCKDH--CEKSLLQLLNEKDNTGCS---PLHYASREGHIRSLENLIRLGACINLKNN 431
           + A+C+ H  C  SLLQ   E D +  S   PL+ A    +  +++ L++  A  N + N
Sbjct: 88  YLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN 147

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              + LH +          Q+L S  G   +   +  G TPL +A++ G    +  L   
Sbjct: 148 RGWTALHESVSRNDLEVM-QILVS--GGAKVESKNAYG-TPLFVAAQSGQLEALRFLAKY 203

Query: 492 GALLHRD-HNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSS 550
           GA ++    +  + L+ A  + + + +E L S  +   ++ +KDG   LH+A+ +     
Sbjct: 204 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADA-NKTNKDGLLPLHIASKKGNYRI 262

Query: 551 IALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVT 588
           + +LL +  R       +S +  A      E   A+++
Sbjct: 263 VQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLS 300



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 2/120 (1%)

Query: 472 PLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           PL  A ++G    +  ++  G  L   +  G  PLH AA  G    +++L   +   +DQ
Sbjct: 19  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 78

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDY-AIYYKFPEAALAMVTH 589
                 T+++LAT       +  LL  G     +N       Y A   K  EA   +V H
Sbjct: 79  RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 138


>X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein.
          Length = 1431

 Score = 91.5 bits (217), Expect = 2e-17
 Identities = 72/249 (28%), Positives = 113/249 (45%), Gaps = 13/249 (5%)

Query: 319 DINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFA 378
           D+N  +K    PLL+AA     + +  LI+ G+ I ++D    N ++    + G ++   
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARH-GHVDTLK 429

Query: 379 ASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL-KNNNNESPL 437
              ++ C       L+ KD +G   LH A+R GH    +      A I + +    E+PL
Sbjct: 430 FLSENKCP------LDVKDKSGEMALHVAARYGHADVAQVTCAASAQIPISRTKEEETPL 483

Query: 438 HFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           H AA +G +  A  L ++      +N  + EG TPL  AS  G+  +V  L   GA L+ 
Sbjct: 484 HCAAWHGYYSVAKALCEAGCN---VNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 540

Query: 498 -DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
            D +G   LHLA      + I+ L S     +D  D+ GNT LH+A  +     +  L  
Sbjct: 541 CDKDGHIALHLAVRRCQMEVIKTLLS-QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 599

Query: 557 MGCRLSYNN 565
             C L  +N
Sbjct: 600 ANCNLDISN 608



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 72/263 (27%), Positives = 117/263 (44%), Gaps = 11/263 (4%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLK 356
           P+  AA   + +I+  LI  GS I+  DK   + +  AA      T+  L      + +K
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441

Query: 357 DINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSL 416
           D +    LH V    G  +    +C    +  + +   E+     +PLH A+  G+    
Sbjct: 442 DKSGEMALH-VAARYGHADVAQVTCAASAQIPISRTKEEE-----TPLHCAAWHGYYSVA 495

Query: 417 ENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIA 476
           + L   G  +N+KN   E+PL  A+  G +H   + L ++ G   +N  D +G   LH+A
Sbjct: 496 KALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL-AEHGA-DLNACDKDGHIALHLA 552

Query: 477 SREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDG 535
            R     V+  LL++G  + ++D +G  PLH+A   G    +  L   + + LD  +K G
Sbjct: 553 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN-LDISNKYG 611

Query: 536 NTSLHLATMENKPSSIALLLSMG 558
            T LHLA        +  L  MG
Sbjct: 612 RTPLHLAANNGILDVVRYLCLMG 634



 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 66/261 (25%), Positives = 108/261 (41%), Gaps = 15/261 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+   ++L +   SR+ V+D  G  A + A+   + + L F++     L+ KD +
Sbjct: 386 AAGCGNIQ-ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEK-CQAPIHMATELNKVSVLQVFAKYKSL 138
           G   LHVA      D  +       +  +   K  + P+H A      SV +  A  ++ 
Sbjct: 445 GEMALHVAARYGHADVAQVTCAASAQIPISRTKEEETPLHCAAWHGYYSVAK--ALCEAG 502

Query: 139 FNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
            NVN     G T L  A+    HD+     + +  A+      +G+  +H A +      
Sbjct: 503 CNVNIKNREGETPLLTASARGYHDIVE--CLAEHGADLNACDKDGHIALHLAVRRCQMEV 560

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           I+  L     +GC     +   D  GN PLH A   G++  V     +   +        
Sbjct: 561 IKTLL----SQGC----FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 612

Query: 258 TPVHLACAQGALDIVKLMFTM 278
           TP+HLA   G LD+V+ +  M
Sbjct: 613 TPLHLAANNGILDVVRYLCLM 633



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 64/286 (22%), Positives = 112/286 (39%), Gaps = 14/286 (4%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDI 271
           R   I + D  G+  ++ A   G +  ++    +   +  +       +H+A   G  D+
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 272 VKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            ++      +       S   ++ TP+HCAA   +  +   L   G ++N  ++E  +PL
Sbjct: 461 AQVTCAASAQIP----ISRTKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPL 516

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A++R     V  L   GAD+   D +    LHL V    ++E         C      
Sbjct: 517 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKTLLSQGC------ 569

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH AA  G       
Sbjct: 570 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 629

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           L         +     +G T   +A  E H  V  LL       HR
Sbjct: 630 LCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 672



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 46/177 (25%), Positives = 83/177 (46%), Gaps = 6/177 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N+ +  G  PL  A+  G+I+ L+ LI+ G+ I++++    + +++AAR+G   T  + 
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT-LKF 430

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAM 510
           L  +K    + +  GE    LH+A+R GH  V  +     A   + R      PLH AA 
Sbjct: 431 LSENKCPLDVKDKSGE--MALHVAARYGHADVAQVTCAASAQIPISRTKEEETPLHCAAW 488

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            GY    + L     + ++  +++G T L  A+       +  L   G  L+  + D
Sbjct: 489 HGYYSVAKALCEAGCN-VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 544



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 32/147 (21%), Positives = 61/147 (41%), Gaps = 2/147 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +    D +       + L   D  G  A H A  R    ++  + +    ++ +D  G
Sbjct: 519 ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG 578

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
           NTPLHVA ++  +  +  L + +    + N+  + P+H+A     + V++      +  +
Sbjct: 579 NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA--S 636

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKIL 167
           V      G+TA   A    H+  A +L
Sbjct: 637 VEALTTDGKTAEDLARSEQHEHVAGLL 663


>BC042173-1|AAH42173.1|  722|Homo sapiens ankyrin repeat domain 6
           protein.
          Length = 722

 Score = 91.5 bits (217), Expect = 2e-17
 Identities = 75/257 (29%), Positives = 120/257 (46%), Gaps = 14/257 (5%)

Query: 301 AAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS 360
           AA     E V  LIN+G+ +  + K  R+PL LAA++     V  L++ G D+ ++D   
Sbjct: 17  AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75

Query: 361 RNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLI 420
           +  LH   +  G  E  AA   + C       L+ +D  G + LH AS  G  +S + L+
Sbjct: 76  QTALHRATV-VGNTEIIAALIHEGC------ALDRQDKDGNTALHEASWHGFSQSAKLLV 128

Query: 421 RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREG 480
           + GA +  KN    + LH A +     +   LL +     + N +   G T LH+A+R  
Sbjct: 129 KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAARYN 185

Query: 481 HTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSL 539
           H  ++ LLL     +H ++  G   LH+AA   + K  ++L    +     ++  G T L
Sbjct: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPL 244

Query: 540 HLATMENKPSSIALLLS 556
             A   N P  +ALLL+
Sbjct: 245 ETARYHNNP-EVALLLT 260



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 14/263 (5%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           LL+AA +     V  LI  GA + +   + R  LHL   N G L       K  C+   L
Sbjct: 14  LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAA-NKGHLPVVQILLKAGCD---L 68

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
            + ++ D T    LH A+  G+   +  LI  G  ++ ++ +  + LH A+ +G   +A 
Sbjct: 69  DVQDDGDQTA---LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAA 509
            L+ +       N++   G T LH+A +  H++   +LL  G+     +N G   LH+AA
Sbjct: 126 LLVKAGANVLAKNKA---GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA 182

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDM 568
              +   I LL +    + ++ ++ G+T+LH+A   N      +LL  G   +  NN   
Sbjct: 183 RYNHLSIIRLLLTAFCSVHEK-NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQ 241

Query: 569 SAIDYAIYYKFPEAALAMVTHEQ 591
           + ++ A Y+  PE AL +    Q
Sbjct: 242 TPLETARYHNNPEVALLLTKAPQ 264



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 63/214 (29%), Positives = 97/214 (45%), Gaps = 11/214 (5%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA   H  +V  L+  G D++  D   ++ L  A        +  LI  G  +  
Sbjct: 44  TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           +D +    LH    +G     F+ S K    K+   +L  K+  G + LH A +  H +S
Sbjct: 104 QDKDGNTALHEASWHG-----FSQSAK-LLVKAGANVL-AKNKAGNTALHLACQNSHSQS 156

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHI 475
              L+  G+  +LKNN  ++ LH AARY        LL +      ++E +  G T LH+
Sbjct: 157 TRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA---FCSVHEKNQAGDTALHV 213

Query: 476 ASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLA 508
           A+   H +V  +LL  GA     +N G+ PL  A
Sbjct: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247



 Score = 65.3 bits (152), Expect = 1e-09
 Identities = 65/276 (23%), Positives = 113/276 (40%), Gaps = 21/276 (7%)

Query: 34  LSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEAL 93
           +S+   +A    R   AA++    N   ++  IN   G   A    G TPLH+A     L
Sbjct: 1   MSQQDAVAALSERLLVAAYKGQTEN---VVQLINK--GARVAVTKHGRTPLHLAANKGHL 55

Query: 94  DAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALH 153
             ++ LL+   +  V ++  Q  +H AT +    +  + A       +++  + G TALH
Sbjct: 56  PVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEI--IAALIHEGCALDRQDKDGNTALH 113

Query: 154 FAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTRE 213
            A+ H     AK+L+    A        G   +H A +N+ S++  V L  G +      
Sbjct: 114 EASWHGFSQSAKLLV-KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR------ 166

Query: 214 QMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVK 273
               L +N G+  LH A     +  + L L +   +  +     T +H+A A     + K
Sbjct: 167 --ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224

Query: 274 LMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
           ++      E  A  T  +    TP+  A   ++PE+
Sbjct: 225 ILL-----EAGADTTIVNNAGQTPLETARYHNNPEV 255



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 4/171 (2%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +A   GN +    L + E   L  +D  G TA H+AS    +     +     ++ AK+ 
Sbjct: 81  RATVVGNTEIIAAL-IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNK 139

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           AGNT LH+A +N    +   LL       + N      +H+A   N +S++++     + 
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL--LTAF 197

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEA 189
            +V++  + G TALH AA  +H   AKIL+ +  A+     N G  P+  A
Sbjct: 198 CSVHEKNQAGDTALHVAAALNHKKVAKILL-EAGADTTIVNNAGQTPLETA 247



 Score = 52.8 bits (121), Expect = 7e-06
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 24/212 (11%)

Query: 146 EHGRTALHFAAIHDHDLCAKILIT---DLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
           +HGRT LH AA   H    +IL+    DLD +     +     +H A    ++  I   +
Sbjct: 40  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ----DDGDQTALHRATVVGNTEIIAALI 95

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                 GC  ++     D +GN  LH A   G  ++ +L +++GA +  +    +T +HL
Sbjct: 96  H----EGCALDRQ----DKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHL 147

Query: 263 ACAQGALDIVKLMFTMQPKE--KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           AC        +++     +   K+    +C       +H AA ++H  I+  L+     +
Sbjct: 148 ACQNSHSQSTRVLLLAGSRADLKNNAGDTC-------LHVAARYNHLSIIRLLLTAFCSV 200

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           +  ++   + L +AA+    +    L+  GAD
Sbjct: 201 HEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 49/211 (23%), Positives = 92/211 (43%), Gaps = 12/211 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G++   +++ L     L V+D   +TA H+A+   NT I+  + +    L+ +D  
Sbjct: 49  AANKGHLP-VVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD 107

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           GNT LH A  +    + + L++        N+     +H+A + +     +V     S  
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           ++      G T LH AA ++H    ++L+T   +  +K    G   +H AA     +  +
Sbjct: 168 DLKNNA--GDTCLHVAARYNHLSIIRLLLTAFCSVHEKN-QAGDTALHVAAALNHKKVAK 224

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
           + L+ G           ++ +N G  PL +A
Sbjct: 225 ILLEAGAD--------TTIVNNAGQTPLETA 247



 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 29/114 (25%), Positives = 53/114 (46%)

Query: 31  RLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVEN 90
           R+ L   SR  +++  G T  H A+  N+ +I+  +      ++ K+ AG+T LHVA   
Sbjct: 158 RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAAL 217

Query: 91  EALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQG 144
                 + LL+   +T+++N   Q P+  A   N   V  +  K   +   ++G
Sbjct: 218 NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRG 271


>BC110915-1|AAI10916.1|  553|Homo sapiens ASB3 protein protein.
          Length = 553

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 44  DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 98

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 99  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 158

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 159 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 212

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 213 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 269

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 270 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 301



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 52  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 111

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 112 --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 169

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 170 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 223

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 224 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 281

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 282 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 334



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 46  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 105

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 106 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 165

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 166 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 204



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 52  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 110

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 111 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 170

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 171 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 223

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 224 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 275

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 276 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 330

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 331 LEILLRNG 338



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 76  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 130

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 131 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 186

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 187 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 246

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 247 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 296

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 297 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 334



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 87/334 (26%), Positives = 140/334 (41%), Gaps = 36/334 (10%)

Query: 99  LLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIH 158
           L++Q   T    + C   + +A     V VL+   K     +V+     G   +H AA H
Sbjct: 32  LVKQMDFTEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYH 88

Query: 159 DHDLCAKILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           +   C ++LI    +E   K     G+  +H AA     + +++ L+ G     T     
Sbjct: 89  NSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--- 145

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKL 274
                E   PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL
Sbjct: 146 -----EETTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKL 199

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +       K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +A
Sbjct: 200 LL-----RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 254

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQL 392
           A     + V  L+  GAD  L   N          +  +L   AA+   H +    L+ L
Sbjct: 255 AQEGHTKCVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPL 304

Query: 393 LNEKDNTG---CSPLHYASREGHIRSLENLIRLG 423
            N   +TG    SP++ A   GH   LE L+R G
Sbjct: 305 TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 338



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 84  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 143

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 144 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 203

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 204 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 260

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 261 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 312

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 313 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 368

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 369 VNILLKYGAQINEL 382



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 149 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 208

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 209 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 265

Query: 520 LHS 522
           L S
Sbjct: 266 LLS 268


>BC009569-1|AAH09569.1|  518|Homo sapiens ankyrin repeat and SOCS
           box-containing 3 protein.
          Length = 518

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 64  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 124 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 177

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 178 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 234

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 235 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 41  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 95

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 96  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 151

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 261

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 262 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 299



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 333

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 334 VNILLKYGAQINEL 347



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>BC006488-1|AAH06488.1|  518|Homo sapiens ankyrin repeat and SOCS
           box-containing 3 protein.
          Length = 518

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 64  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 124 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 177

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 178 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 234

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 235 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 41  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 95

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 96  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 151

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 261

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 262 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 299



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 333

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 334 VNILLKYGAQINEL 347



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>AK000985-1|BAA91455.1|  518|Homo sapiens protein ( Homo sapiens
           cDNA FLJ10123 fis, clone HEMBA1002939, weakly similar to
           ANKYRIN R. ).
          Length = 518

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 64  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 124 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 177

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 178 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 234

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 235 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 41  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 95

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 96  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 151

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 261

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 262 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 299



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 333

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 334 VNILLKYGAQINEL 347



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>AF156778-1|AAD41895.1|  518|Homo sapiens ASB-3 protein protein.
          Length = 518

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 64  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 124 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 177

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 178 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 234

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 235 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 41  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 95

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 96  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 151

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 261

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 262 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 299



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 333

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 334 VNILLKYGAQINEL 347



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>AC007883-1|AAY24350.1|  326|Homo sapiens unknown protein.
          Length = 326

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 9   DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 64  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 124 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 177

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 178 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 234

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 235 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 41  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 95

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 96  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 151

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 261

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 262 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 299



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 61/275 (22%), Positives = 114/275 (41%), Gaps = 17/275 (6%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACL 287
            +  +PV+ A   G  D ++++       +  ACL
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>AB209795-1|BAD93032.1|  340|Homo sapiens ankyrin repeat and SOCS
           box-containing protein 3 isoform a variant protein.
          Length = 340

 Score = 90.2 bits (214), Expect = 4e-17
 Identities = 80/272 (29%), Positives = 125/272 (45%), Gaps = 20/272 (7%)

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D  + V LA  +G + +++ +      +K   +   D +   PIH AA  +  E +  LI
Sbjct: 19  DTCSTVGLAAREGNVKVLRKLL-----KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 73

Query: 315 NEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           N  S  N +     E    L LAAS+  W+ V  L+  GAD     +     L L V NG
Sbjct: 74  NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 133

Query: 372 GRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNN 431
               D       H       +       G + LH AS + +   ++ L+R GA    +++
Sbjct: 134 QI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDD 187

Query: 432 NNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR 491
              +PL  AA+YG+  +   L+ S      +N    +  TPL IA++EGHT+ V LLL+ 
Sbjct: 188 FGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSS 244

Query: 492 GA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 245 GADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 276



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 69/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 27  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 86

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 87  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 144

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 145 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 198

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 199 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 256

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 257 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 309



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 21  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 80

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 81  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 140

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 141 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 179



 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 27  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 85

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 86  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 145

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 146 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 198

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 199 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 250

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 251 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 305

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 306 LEILLRNG 313



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 51  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 105

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 106 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 161

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 162 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 221

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 222 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 271

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 272 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 309



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 87/334 (26%), Positives = 140/334 (41%), Gaps = 36/334 (10%)

Query: 99  LLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIH 158
           L++Q   T    + C   + +A     V VL+   K     +V+     G   +H AA H
Sbjct: 7   LVKQMDFTEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYH 63

Query: 159 DHDLCAKILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           +   C ++LI    +E   K     G+  +H AA     + +++ L+ G     T     
Sbjct: 64  NSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--- 120

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKL 274
                E   PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL
Sbjct: 121 -----EETTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKL 174

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +       K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +A
Sbjct: 175 LL-----RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 229

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQL 392
           A     + V  L+  GAD  L   N          +  +L   AA+   H +    L+ L
Sbjct: 230 AQEGHTKCVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPL 279

Query: 393 LNEKDNTG---CSPLHYASREGHIRSLENLIRLG 423
            N   +TG    SP++ A   GH   LE L+R G
Sbjct: 280 TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 313



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 61/275 (22%), Positives = 114/275 (41%), Gaps = 17/275 (6%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 59  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 118

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 119 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 178

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 179 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 235

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 236 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 287

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACL 287
            +  +PV+ A   G  D ++++       +  ACL
Sbjct: 288 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 322



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 124 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 183

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 184 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 240

Query: 520 LHS 522
           L S
Sbjct: 241 LLS 243


>AB051515-1|BAB21819.1| 1644|Homo sapiens KIAA1728 protein protein.
          Length = 1644

 Score = 89.8 bits (213), Expect = 5e-17
 Identities = 91/360 (25%), Positives = 154/360 (42%), Gaps = 14/360 (3%)

Query: 235  DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK 294
            ++K   L +  GA ++ +   L+    + C Q  L   +++  +   E  ACL       
Sbjct: 695  NVKVSRLLILGGANVNYRTEVLNN-APILCVQSHLGHEEVVTLLL--EFGACLDGTSENG 751

Query: 295  MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG---A 351
            MT +  AA   H ++V  L  +G  ++ LDK+ +  L+ +A R     +  L+       
Sbjct: 752  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 811

Query: 352  DIQLKDINSRNVLHLVVMNGGRL-EDFAASCKDHCEKSLLQLLNEKDNT-GCSPLHYASR 409
              Q   +   + L   +     +       C    EK     +N  D   G + L  A+ 
Sbjct: 812  PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 871

Query: 410  EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEG 469
             G +   E L+  GA ++  N     PL  AAR G +     LL+  +G  + N SD +G
Sbjct: 872  RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE--RGCDV-NLSDKQG 928

Query: 470  LTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
             TPL +A+ EGH   V  LL++GA L   D  G + L  A + G+   ++ L       +
Sbjct: 929  RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE-EGAAI 987

Query: 529  DQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYAIYYKFPEAALAMV 587
            DQ DK+G T L LA       ++  L+  G  + + ++  M  +D AI  +     +A++
Sbjct: 988  DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALL 1047



 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 93/342 (27%), Positives = 143/342 (41%), Gaps = 27/342 (7%)

Query: 232  HGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCD 291
            H G  + V L L  GA +     +  T +  A A G + +V L+     +  H      D
Sbjct: 727  HLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHL-----D 781

Query: 292  VQKMTPIHCAAMFDHPEIVNYLIN-EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
             +    +  +A+  H +I+ YL+  E S   P       P  L  S A  + +     +G
Sbjct: 782  KKGQCALVHSALRGHGDILQYLLTCEWSPGPP------QPGTLRKSHALQQALTAAASMG 835

Query: 351  ADIQLKDINSRNVLHLVVMNG-----GRLEDFAASCKDHCEKSLLQL-----LNEKDNTG 400
                ++ +      H V +NG     G     AA+ +   E   L L     ++  +  G
Sbjct: 836  HSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRG 895

Query: 401  CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
              PL  A+R+GH + +  L+  G  +NL +    +PL  AA  G   T   LL   KG  
Sbjct: 896  VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLS--KGA- 952

Query: 461  IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIEL 519
             ++  D EGL+ L  A  +GH  VV  L+  GA + + D NGR PL LAA  G  +T+  
Sbjct: 953  ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLY 1012

Query: 520  LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            L      +++ +D  G   L  A      S +  LL  G +L
Sbjct: 1013 LVE-KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1053



 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 80/284 (28%), Positives = 122/284 (42%), Gaps = 19/284 (6%)

Query: 220  DNEGNVPL-HSAVHG-GDIKAVEL-CLRSGAKIST----QQHDLSTPVHLACAQGALDIV 272
            D +G   L HSA+ G GDI    L C  S          + H L   +  A + G   +V
Sbjct: 781  DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 840

Query: 273  KLMFTMQPKEKHACLTSCD-VQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            + +  M+ KE    +   D +   T +  AA     E+   L+  G+ ++  ++    PL
Sbjct: 841  QCLLGME-KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPL 899

Query: 332  LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
              AA +  W+ V  L+  G D+ L D   R  L +    G       ++ +    K    
Sbjct: 900  FCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEG-----HLSTVEFLLSKGAA- 953

Query: 392  LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
             L+  D  G S L +A  +GH   ++ L+  GA I+  + N  +PL  AA YG   T   
Sbjct: 954  -LSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLY 1012

Query: 452  LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL 495
            L+  +KG  +I   D  G+ PL  A    +T VV  LL +GA L
Sbjct: 1013 LV--EKGA-VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1053



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 78/319 (24%), Positives = 126/319 (39%), Gaps = 28/319 (8%)

Query: 47   GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPL-HVAVENEALDAIEYLLQ---- 101
            G TA   A+A  +  ++  +      ++  D  G   L H A+     D ++YLL     
Sbjct: 751  GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHG-DILQYLLTCEWS 809

Query: 102  ---QHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEH---GRTALHFA 155
                   T   +   Q  +  A  +   SV+Q     +    V   G     G TAL  A
Sbjct: 810  PGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 869

Query: 156  AIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQ 214
            A     ++C   L+    A   +    G  P+  AA+    + + + L+    RGC    
Sbjct: 870  AGRGKLEVCE--LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE----RGCD--- 920

Query: 215  MISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKL 274
             ++L D +G  PL  A   G +  VE  L  GA +S+   +  + +  AC +G   +V+ 
Sbjct: 921  -VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 979

Query: 275  MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
            +      E+ A +   D    TP+  AA +   E V YL+ +G+ I  +D     PL  A
Sbjct: 980  LV-----EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1034

Query: 335  ASRAGWRTVHTLIRLGADI 353
                    V  L+R GA +
Sbjct: 1035 IGCRNTSVVVALLRKGAKL 1053



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 42/190 (22%), Positives = 83/190 (43%), Gaps = 4/190 (2%)

Query: 20   AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
            AA  G ++    L L   + ++  + RG      A+ + +  I+  +     D+N  D  
Sbjct: 869  AAGRGKLE-VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 927

Query: 80   GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            G TPL VA     L  +E+LL +    S L+++  + +  A      +V+Q   +  +  
Sbjct: 928  GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA- 986

Query: 140  NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
             ++Q  ++GRT L  AA +  D    + + +  A  +   ++G  P+  A    ++  + 
Sbjct: 987  -IDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVV 1044

Query: 200  VFLQWGEQRG 209
              L+ G + G
Sbjct: 1045 ALLRKGAKLG 1054



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 43/213 (20%), Positives = 91/213 (42%), Gaps = 13/213 (6%)

Query: 47   GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
            G TA   A+ R    +   +  +   ++  +  G  PL  A        +  LL++  + 
Sbjct: 862  GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 921

Query: 107  SVLNEKCQAPIHMATELNKVSVLQ-VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            ++ +++ + P+ +A     +S ++ + +K  +L ++++    G +AL +A +  H    +
Sbjct: 922  NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDK---EGLSALSWACLKGHRAVVQ 978

Query: 166  ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
             L+ +  A   +   NG  P+  AA    + T+   ++ G         +I   D+ G  
Sbjct: 979  YLVEE-GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA--------VIEHVDHSGMR 1029

Query: 226  PLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
            PL  A+   +   V   LR GAK+      ++T
Sbjct: 1030 PLDRAIGCRNTSVVVALLRKGAKLGNAAWAMAT 1062


>BC066643-1|AAH66643.1| 1202|Homo sapiens CASK interacting protein 2
           protein.
          Length = 1202

 Score = 88.2 bits (209), Expect = 2e-16
 Identities = 73/260 (28%), Positives = 121/260 (46%), Gaps = 22/260 (8%)

Query: 352 DIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
           ++  +D +  + LH   + GG LE  A   +      +      KD+ G  PLHYA+ +G
Sbjct: 41  NVNYQDADGFSALHHAAL-GGSLELIALLLEAQATVDI------KDSNGMRPLHYAAWQG 93

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
            +  +  L+R  A +N  + + + PLH AA+YG +  +  LL       ++N++     T
Sbjct: 94  RLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK---KT 150

Query: 472 PLHIASREGHTRVVHLLLNRG---ALLHR------DHNGRNPLHLAAMSGYTKTIELLHS 522
           PL +A   G  +V  LLLN     ALL        D N   PLHLAA +G+ + I  L  
Sbjct: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYAIYYKFPE 581
               +  Q  K G T+LH A +  K   + LLL  G  ++  N  + +A+D    +   +
Sbjct: 211 AGIEINRQ-TKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQ 268

Query: 582 AALAMVTHEQRAKEVMALRS 601
           A+  +    + A  ++ +R+
Sbjct: 269 ASREIKQLLREASGILKVRA 288



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 59/243 (24%), Positives = 104/243 (42%), Gaps = 21/243 (8%)

Query: 209 GCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
           G T+   ++  D +G   LH A  GG ++ + L L + A +  +  +   P+H A  QG 
Sbjct: 35  GSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGR 94

Query: 269 LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR 328
           L+ V+L+         A + +  +    P+H AA + H E+   L+   S+   ++K ++
Sbjct: 95  LEPVRLLL-----RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLK--------DINSRNVLHLVVMNGGRLEDFAAS 380
           +PL LA      +    L+     + L         D N    LHL   NG R E     
Sbjct: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR-EVIRQL 208

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
            +   E      +N +  TG + LH A+  G    +  L+  G  +N++N  N++ L   
Sbjct: 209 LRAGIE------INRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 261

Query: 441 ARY 443
            ++
Sbjct: 262 NQF 264



 Score = 58.4 bits (135), Expect = 1e-07
 Identities = 58/229 (25%), Positives = 96/229 (41%), Gaps = 26/229 (11%)

Query: 34  LSEPSRLAV--RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L    RL V  +D  G +A H A+   +  ++  +      ++ KD+ G  PLH A    
Sbjct: 34  LGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQG 93

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS---LFN------VN 142
            L+ +  LL+     +  +   Q P+H+A +     V ++  +++S   L N      ++
Sbjct: 94  RLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLD 153

Query: 143 QGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEAAKNASSRTIEVF 201
              E GR  +    ++ H LC  +    L+ E K PC+  Y  P+H AAKN     I   
Sbjct: 154 LACEFGRLKVAQLLLNSH-LCVAL----LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS 250
           L+ G +        I+     G   LH A   G  + V L L  G  ++
Sbjct: 209 LRAGIE--------INRQTKTGTA-LHEAALYGKTEVVRLLLEGGVDVN 248



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 42/192 (21%), Positives = 80/192 (41%), Gaps = 9/192 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+++  + L L   + + ++D  G    H A+ +     +  +   +  +NA    
Sbjct: 56  AALGGSLE-LIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLD 114

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G  PLH+A +    +  E LLQ      ++N+  + P+ +A E  ++ V Q+        
Sbjct: 115 GQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCV 174

Query: 140 NVNQG------GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
            + +G        +  T LH AA + H    + L+     E  +    G   +HEAA   
Sbjct: 175 ALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR-AGIEINRQTKTG-TALHEAALYG 232

Query: 194 SSRTIEVFLQWG 205
            +  + + L+ G
Sbjct: 233 KTEVVRLLLEGG 244


>AF451976-1|AAL49757.1| 1202|Homo sapiens cask-interacting protein 2
           protein.
          Length = 1202

 Score = 88.2 bits (209), Expect = 2e-16
 Identities = 73/260 (28%), Positives = 121/260 (46%), Gaps = 22/260 (8%)

Query: 352 DIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
           ++  +D +  + LH   + GG LE  A   +      +      KD+ G  PLHYA+ +G
Sbjct: 41  NVNYQDADGFSALHHAAL-GGSLELIALLLEAQATVDI------KDSNGMRPLHYAAWQG 93

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
            +  +  L+R  A +N  + + + PLH AA+YG +  +  LL       ++N++     T
Sbjct: 94  RLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK---KT 150

Query: 472 PLHIASREGHTRVVHLLLNRG---ALLHR------DHNGRNPLHLAAMSGYTKTIELLHS 522
           PL +A   G  +V  LLLN     ALL        D N   PLHLAA +G+ + I  L  
Sbjct: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYAIYYKFPE 581
               +  Q  K G T+LH A +  K   + LLL  G  ++  N  + +A+D    +   +
Sbjct: 211 AGIEINRQ-TKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQ 268

Query: 582 AALAMVTHEQRAKEVMALRS 601
           A+  +    + A  ++ +R+
Sbjct: 269 ASREIKQLLREASGILKVRA 288



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 59/243 (24%), Positives = 104/243 (42%), Gaps = 21/243 (8%)

Query: 209 GCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGA 268
           G T+   ++  D +G   LH A  GG ++ + L L + A +  +  +   P+H A  QG 
Sbjct: 35  GSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGR 94

Query: 269 LDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERR 328
           L+ V+L+         A + +  +    P+H AA + H E+   L+   S+   ++K ++
Sbjct: 95  LEPVRLLL-----RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLK--------DINSRNVLHLVVMNGGRLEDFAAS 380
           +PL LA      +    L+     + L         D N    LHL   NG R E     
Sbjct: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR-EVIRQL 208

Query: 381 CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
            +   E      +N +  TG + LH A+  G    +  L+  G  +N++N  N++ L   
Sbjct: 209 LRAGIE------INRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 261

Query: 441 ARY 443
            ++
Sbjct: 262 NQF 264



 Score = 58.4 bits (135), Expect = 1e-07
 Identities = 58/229 (25%), Positives = 96/229 (41%), Gaps = 26/229 (11%)

Query: 34  LSEPSRLAV--RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L    RL V  +D  G +A H A+   +  ++  +      ++ KD+ G  PLH A    
Sbjct: 34  LGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQG 93

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS---LFN------VN 142
            L+ +  LL+     +  +   Q P+H+A +     V ++  +++S   L N      ++
Sbjct: 94  RLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLD 153

Query: 143 QGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGY-YPIHEAAKNASSRTIEVF 201
              E GR  +    ++ H LC  +    L+ E K PC+  Y  P+H AAKN     I   
Sbjct: 154 LACEFGRLKVAQLLLNSH-LCVAL----LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKIS 250
           L+ G +        I+     G   LH A   G  + V L L  G  ++
Sbjct: 209 LRAGIE--------INRQTKTGTA-LHEAALYGKTEVVRLLLEGGVDVN 248



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 42/192 (21%), Positives = 80/192 (41%), Gaps = 9/192 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+++  + L L   + + ++D  G    H A+ +     +  +   +  +NA    
Sbjct: 56  AALGGSLE-LIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLD 114

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G  PLH+A +    +  E LLQ      ++N+  + P+ +A E  ++ V Q+        
Sbjct: 115 GQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCV 174

Query: 140 NVNQG------GEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNA 193
            + +G        +  T LH AA + H    + L+     E  +    G   +HEAA   
Sbjct: 175 ALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR-AGIEINRQTKTG-TALHEAALYG 232

Query: 194 SSRTIEVFLQWG 205
            +  + + L+ G
Sbjct: 233 KTEVVRLLLEGG 244


>AK222715-1|BAD96435.1|  512|Homo sapiens ankyrin repeat and SOCS
           box-containing protein 3 isoform a variant protein.
          Length = 512

 Score = 87.8 bits (208), Expect = 2e-16
 Identities = 73/230 (31%), Positives = 108/230 (46%), Gaps = 15/230 (6%)

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDK---ERRSPLLLAASRAGWRTVHTLIRLGADI 353
           PIH AA  +  E +  LIN  S  N +     E    L LAAS+  W+ V  L+  GAD 
Sbjct: 40  PIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 99

Query: 354 QLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
               +     L L V NG    D       H       +       G + LH AS + + 
Sbjct: 100 NATTLEETTPLFLAVENGQI--DVLRLLLQHGAN----VNGSHSMCGWNSLHQASFQENA 153

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPL 473
             ++ L+R GA    +++   +PL  AA+YG+  +   L+ S      +N    +  TPL
Sbjct: 154 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN---VNCQALDKATPL 210

Query: 474 HIASREGHTRVVHLLLNRGA---LLHRDHNGRNPLHLAAMSGYTKTIELL 520
            IA++EGHT+ V LLL+ GA   L   + + + P+H AA  G+TK ++LL
Sbjct: 211 FIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 260



 Score = 81.8 bits (193), Expect = 1e-14
 Identities = 68/293 (23%), Positives = 131/293 (44%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A    ++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 11  AAREANVKVLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 70

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 71  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 128

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    ++ A   K    K   +    +D+ G +PL  A++
Sbjct: 129 GANVN----GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 182

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 183 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 240

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 241 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 293



 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 45/159 (28%), Positives = 75/159 (47%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+RE +++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 5   CSTVGLAAREANVKVLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 64

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 65  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 124

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ +     I LLL  G
Sbjct: 125 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 163



 Score = 71.7 bits (168), Expect = 1e-11
 Identities = 77/308 (25%), Positives = 127/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA   NV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 11  AAREANVK-VLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 69

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 70  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 129

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  ++    K+L   L     K C +  G  P+  AA+
Sbjct: 130 A--NVN--GSHSMCGWNSLHQASFQENAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 182

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 183 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 234

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 235 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 289

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 290 LEILLRNG 297



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 68/279 (24%), Positives = 124/279 (44%), Gaps = 25/279 (8%)

Query: 180 NNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAV 239
           N G+ PIHEAA + S   +++ +        + E  I +   EG   LH A   G  K V
Sbjct: 35  NRGWMPIHEAAYHNSVECLQMLIN-----ADSSENYIKMKTFEGFCALHLAASQGHWKIV 89

Query: 240 ELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           ++ L +GA  +    + +TP+ LA   G +D+++L+        +   + C       +H
Sbjct: 90  QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNGSHSMCG---WNSLH 145

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            A+  ++ EI+  L+ +G++    D    +PL +AA      ++  LI  GA++  + ++
Sbjct: 146 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 205

Query: 360 SRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
               L +    G    +E   +S  D   +C +   QL          P+H A++ GH +
Sbjct: 206 KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL----------PIHAAAQMGHTK 255

Query: 415 SLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
            L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 256 ILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 293



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 84/313 (26%), Positives = 133/313 (42%), Gaps = 36/313 (11%)

Query: 120 ATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAE--WKK 177
           A E N   + Q+  K +S   V+     G   +H AA H+   C ++LI    +E   K 
Sbjct: 12  AREANVKVLRQLLKKGRS---VDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKM 68

Query: 178 PCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK 237
               G+  +H AA     + +++ L+ G     T          E   PL  AV  G I 
Sbjct: 69  KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EETTPLFLAVENGQID 120

Query: 238 AVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
            + L L+ GA ++   H +     +H A  Q   +I+KL+       K A     D   +
Sbjct: 121 VLRLLLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL-----RKGANKECQDDFGI 174

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     + V  L+  GAD  L
Sbjct: 175 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 234

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNTG---CSPLHYASRE 410
              N          +  +L   AA+   H +    L+ L N   +TG    SP++ A   
Sbjct: 235 Y-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFG 284

Query: 411 GHIRSLENLIRLG 423
           GH   LE L+R G
Sbjct: 285 GHEDCLEILLRNG 297



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 9/176 (5%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGAC---INLKNNNNESPLHFAARYGRFHTACQLL 453
           DN G  P+H A+    +  L+ LI   +    I +K       LH AA  G +     LL
Sbjct: 34  DNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILL 93

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAAMS 511
           ++       N +  E  TPL +A   G   V+ LLL  GA ++  H+  G N LH A+  
Sbjct: 94  EAGADP---NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQ 150

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
              + I+LL    ++   Q D  G T L +A    K  S+++L+S G  ++   +D
Sbjct: 151 ENAEIIKLLLRKGANKECQ-DDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 205



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 73/314 (23%), Positives = 130/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 43  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 102

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+      ++++  + 
Sbjct: 103 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 162

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 163 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 219

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 220 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 271

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 272 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 327

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 328 VNILLKYGAQINEL 341



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 108 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 167

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 168 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 224

Query: 520 LHS 522
           L S
Sbjct: 225 LLS 227


>D83197-1|BAA34594.1|  226|Homo sapiens gankyrin protein.
          Length = 226

 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 13/209 (6%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL    ++   T    LH+A   GH   +E L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTA---LHWACSAGHTEIVEFL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           ++LG  +N K++   SPLH AA  GR      LL   KG   +N  +  G TPLH A+ +
Sbjct: 60  LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--GKGA-QVNAVNQNGCTPLHYAASK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
               +  +LL  GA    +DH     +H AA  G  K I +L    +    Q D +GNT 
Sbjct: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTP 175

Query: 539 LHLATMENKPSSIALLLSMGCRLSYNNMD 567
           LHLA  E +     LL+S G  +   N +
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIENKE 204



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/158 (32%), Positives = 82/158 (51%), Gaps = 8/158 (5%)

Query: 389 LLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGR 445
           LLQL   +N+KD+ G SPLH A+  G    ++ L+  GA +N  N N  +PLH+AA   R
Sbjct: 59  LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118

Query: 446 FHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
              A  LL+        +  D    T +H A+ +G+ +++H+LL   A  + +D  G  P
Sbjct: 119 HEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           LHLA      +  +LL S  + +  + +K+  T L +A
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIE-NKEEKTPLQVA 212



 Score = 62.5 bits (145), Expect = 9e-09
 Identities = 56/205 (27%), Positives = 92/205 (44%), Gaps = 17/205 (8%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E+   ++ + S     D++ R+ L  A S      V  L++LG  +  KD    + LH+ 
Sbjct: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80

Query: 368 VMNGGRLEDFAASCKDHCEKSLL---QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGA 424
                     A++ +D   K+LL     +N  +  GC+PLHYA+ +        L+  GA
Sbjct: 81  ----------ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130

Query: 425 CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRV 484
             + K++   + +H AA  G       LL     T   N  D EG TPLH+A  E     
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST---NIQDTEGNTPLHLACDEERVEE 187

Query: 485 VHLLLNRGALLH-RDHNGRNPLHLA 508
             LL+++GA ++  +   + PL +A
Sbjct: 188 AKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    T +H A    H EIV +L+  G  +N  D    SPL +AAS      V  L+
Sbjct: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCS 402
             GA +   + N    LH           +AAS K+  E +++ L      + KD+   +
Sbjct: 94  GKGAQVNAVNQNGCTPLH-----------YAAS-KNRHEIAVMLLEGGANPDAKDHYEAT 141

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            +H A+ +G+++ +  L+   A  N+++    +PLH A    R   A  L+      +I 
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201

Query: 463 NESDGEGLTPLHIA 476
           N+   E  TPL +A
Sbjct: 202 NK---EEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 14/194 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +  RTALH+A    H    + L+  L        + G+ P+H AA       ++  L  G
Sbjct: 38  QDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
            Q        ++  +  G  PLH A      +   + L  GA    + H  +T +H A A
Sbjct: 97  AQ--------VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G L ++ ++   +     A     D +  TP+H A   +  E    L+++G+ I   +K
Sbjct: 149 KGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203

Query: 326 ERRSPLLLAASRAG 339
           E ++PL +A    G
Sbjct: 204 EEKTPLQVAKGGLG 217



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 2/136 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D   RTA H A +  +T I+ F+      +N KD+AG
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            +PLH+A      + ++ LL +  + + +N+    P+H A   N+  +  +  +  +  N
Sbjct: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--N 131

Query: 141 VNQGGEHGRTALHFAA 156
            +    +  TA+H AA
Sbjct: 132 PDAKDHYEATAMHRAA 147



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 15/197 (7%)

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           D    T LH A      + +E+LLQ  V  +  ++   +P+H+A    +  +++      
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 137 SLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +   VN   ++G T LH+AA  + H++   +L    + + K   +     +H AA   + 
Sbjct: 97  A--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--HYEATAMHRAAAKGNL 152

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           + I + L +        +   ++ D EGN PLH A     ++  +L +  GA I  +  +
Sbjct: 153 KMIHILLYY--------KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204

Query: 256 LSTPVHLACAQGALDIV 272
             TP  L  A+G L ++
Sbjct: 205 EKTP--LQVAKGGLGLI 219



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +    LH A   G  + VE  L+ G  ++ +     +P+H+A + G  +IVK +    
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG-- 94

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++  
Sbjct: 95  ---KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHL 366
            + +H L+   A   ++D      LHL
Sbjct: 152 LKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           VN   + G + LH AA    D   K L+    A+      NG  P+H AA         +
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVM 124

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            L+ G              D+     +H A   G++K + + L   A  + Q  + +TP+
Sbjct: 125 LLEGGANPDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPL 176

Query: 261 HLACAQGALDIVKLM 275
           HLAC +  ++  KL+
Sbjct: 177 HLACDEERVEEAKLL 191



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 25/106 (23%), Positives = 49/106 (46%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S   D+ ++  L + +++   +  G T  H A+++N   I   +     + +AKD+  
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
            T +H A     L  I  LL     T++ + +   P+H+A +  +V
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 28/127 (22%), Positives = 50/127 (39%), Gaps = 2/127 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +  H A++     I+  +      +NA +  G TPLH A      +    LL+ 
Sbjct: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
                  +      +H A     + ++ +   YK+  N+      G T LH A   +   
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD--TEGNTPLHLACDEERVE 186

Query: 163 CAKILIT 169
            AK+L++
Sbjct: 187 EAKLLVS 193


>BC011960-1|AAH11960.1|  226|Homo sapiens proteasome (prosome,
           macropain) 26S subunit, non-ATPase, 10 protein.
          Length = 226

 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 13/209 (6%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL    ++   T    LH+A   GH   +E L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTA---LHWACSAGHTEIVEFL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           ++LG  +N K++   SPLH AA  GR      LL   KG   +N  +  G TPLH A+ +
Sbjct: 60  LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--GKGA-QVNAVNQNGCTPLHYAASK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
               +  +LL  GA    +DH     +H AA  G  K I +L    +    Q D +GNT 
Sbjct: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTP 175

Query: 539 LHLATMENKPSSIALLLSMGCRLSYNNMD 567
           LHLA  E +     LL+S G  +   N +
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIENKE 204



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/158 (32%), Positives = 82/158 (51%), Gaps = 8/158 (5%)

Query: 389 LLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGR 445
           LLQL   +N+KD+ G SPLH A+  G    ++ L+  GA +N  N N  +PLH+AA   R
Sbjct: 59  LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118

Query: 446 FHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
              A  LL+        +  D    T +H A+ +G+ +++H+LL   A  + +D  G  P
Sbjct: 119 HEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           LHLA      +  +LL S  + +  + +K+  T L +A
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIE-NKEEKTPLQVA 212



 Score = 62.5 bits (145), Expect = 9e-09
 Identities = 56/205 (27%), Positives = 92/205 (44%), Gaps = 17/205 (8%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E+   ++ + S     D++ R+ L  A S      V  L++LG  +  KD    + LH+ 
Sbjct: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80

Query: 368 VMNGGRLEDFAASCKDHCEKSLL---QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGA 424
                     A++ +D   K+LL     +N  +  GC+PLHYA+ +        L+  GA
Sbjct: 81  ----------ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130

Query: 425 CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRV 484
             + K++   + +H AA  G       LL     T   N  D EG TPLH+A  E     
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST---NIQDTEGNTPLHLACDEERVEE 187

Query: 485 VHLLLNRGALLH-RDHNGRNPLHLA 508
             LL+++GA ++  +   + PL +A
Sbjct: 188 AKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    T +H A    H EIV +L+  G  +N  D    SPL +AAS      V  L+
Sbjct: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCS 402
             GA +   + N    LH           +AAS K+  E +++ L      + KD+   +
Sbjct: 94  GKGAQVNAVNQNGCTPLH-----------YAAS-KNRHEIAVMLLEGGANPDAKDHYEAT 141

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            +H A+ +G+++ +  L+   A  N+++    +PLH A    R   A  L+      +I 
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201

Query: 463 NESDGEGLTPLHIA 476
           N+   E  TPL +A
Sbjct: 202 NK---EEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 14/194 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +  RTALH+A    H    + L+  L        + G+ P+H AA       ++  L  G
Sbjct: 38  QDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
            Q        ++  +  G  PLH A      +   + L  GA    + H  +T +H A A
Sbjct: 97  AQ--------VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G L ++ ++   +     A     D +  TP+H A   +  E    L+++G+ I   +K
Sbjct: 149 KGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203

Query: 326 ERRSPLLLAASRAG 339
           E ++PL +A    G
Sbjct: 204 EEKTPLQVAKGGLG 217



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 2/136 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D   RTA H A +  +T I+ F+      +N KD+AG
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            +PLH+A      + ++ LL +  + + +N+    P+H A   N+  +  +  +  +  N
Sbjct: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--N 131

Query: 141 VNQGGEHGRTALHFAA 156
            +    +  TA+H AA
Sbjct: 132 PDAKDHYEATAMHRAA 147



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 15/197 (7%)

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           D    T LH A      + +E+LLQ  V  +  ++   +P+H+A    +  +++      
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 137 SLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +   VN   ++G T LH+AA  + H++   +L    + + K   +     +H AA   + 
Sbjct: 97  A--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--HYEATAMHRAAAKGNL 152

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           + I + L +        +   ++ D EGN PLH A     ++  +L +  GA I  +  +
Sbjct: 153 KMIHILLYY--------KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204

Query: 256 LSTPVHLACAQGALDIV 272
             TP  L  A+G L ++
Sbjct: 205 EKTP--LQVAKGGLGLI 219



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +    LH A   G  + VE  L+ G  ++ +     +P+H+A + G  +IVK +    
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG-- 94

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++  
Sbjct: 95  ---KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHL 366
            + +H L+   A   ++D      LHL
Sbjct: 152 LKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           VN   + G + LH AA    D   K L+    A+      NG  P+H AA         +
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVM 124

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            L+ G              D+     +H A   G++K + + L   A  + Q  + +TP+
Sbjct: 125 LLEGGANPDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPL 176

Query: 261 HLACAQGALDIVKLM 275
           HLAC +  ++  KL+
Sbjct: 177 HLACDEERVEEAKLL 191



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 25/106 (23%), Positives = 49/106 (46%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S   D+ ++  L + +++   +  G T  H A+++N   I   +     + +AKD+  
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
            T +H A     L  I  LL     T++ + +   P+H+A +  +V
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 28/127 (22%), Positives = 50/127 (39%), Gaps = 2/127 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +  H A++     I+  +      +NA +  G TPLH A      +    LL+ 
Sbjct: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
                  +      +H A     + ++ +   YK+  N+      G T LH A   +   
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD--TEGNTPLHLACDEERVE 186

Query: 163 CAKILIT 169
            AK+L++
Sbjct: 187 EAKLLVS 193


>AL031177-5|CAA20117.1|  226|Homo sapiens proteasome (prosome,
           macropain) 26S subunit, non-ATPase, 10 protein.
          Length = 226

 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 13/209 (6%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL    ++   T    LH+A   GH   +E L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTA---LHWACSAGHTEIVEFL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           ++LG  +N K++   SPLH AA  GR      LL   KG   +N  +  G TPLH A+ +
Sbjct: 60  LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--GKGA-QVNAVNQNGCTPLHYAASK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
               +  +LL  GA    +DH     +H AA  G  K I +L    +    Q D +GNT 
Sbjct: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTP 175

Query: 539 LHLATMENKPSSIALLLSMGCRLSYNNMD 567
           LHLA  E +     LL+S G  +   N +
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIENKE 204



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/158 (32%), Positives = 82/158 (51%), Gaps = 8/158 (5%)

Query: 389 LLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGR 445
           LLQL   +N+KD+ G SPLH A+  G    ++ L+  GA +N  N N  +PLH+AA   R
Sbjct: 59  LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118

Query: 446 FHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
              A  LL+        +  D    T +H A+ +G+ +++H+LL   A  + +D  G  P
Sbjct: 119 HEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           LHLA      +  +LL S  + +  + +K+  T L +A
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIE-NKEEKTPLQVA 212



 Score = 62.5 bits (145), Expect = 9e-09
 Identities = 56/205 (27%), Positives = 92/205 (44%), Gaps = 17/205 (8%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E+   ++ + S     D++ R+ L  A S      V  L++LG  +  KD    + LH+ 
Sbjct: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80

Query: 368 VMNGGRLEDFAASCKDHCEKSLL---QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGA 424
                     A++ +D   K+LL     +N  +  GC+PLHYA+ +        L+  GA
Sbjct: 81  ----------ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130

Query: 425 CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRV 484
             + K++   + +H AA  G       LL     T   N  D EG TPLH+A  E     
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST---NIQDTEGNTPLHLACDEERVEE 187

Query: 485 VHLLLNRGALLH-RDHNGRNPLHLA 508
             LL+++GA ++  +   + PL +A
Sbjct: 188 AKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    T +H A    H EIV +L+  G  +N  D    SPL +AAS      V  L+
Sbjct: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCS 402
             GA +   + N    LH           +AAS K+  E +++ L      + KD+   +
Sbjct: 94  GKGAQVNAVNQNGCTPLH-----------YAAS-KNRHEIAVMLLEGGANPDAKDHYEAT 141

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            +H A+ +G+++ +  L+   A  N+++    +PLH A    R   A  L+      +I 
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201

Query: 463 NESDGEGLTPLHIA 476
           N+   E  TPL +A
Sbjct: 202 NK---EEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 14/194 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +  RTALH+A    H    + L+  L        + G+ P+H AA       ++  L  G
Sbjct: 38  QDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
            Q        ++  +  G  PLH A      +   + L  GA    + H  +T +H A A
Sbjct: 97  AQ--------VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G L ++ ++   +     A     D +  TP+H A   +  E    L+++G+ I   +K
Sbjct: 149 KGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203

Query: 326 ERRSPLLLAASRAG 339
           E ++PL +A    G
Sbjct: 204 EEKTPLQVAKGGLG 217



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 2/136 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D   RTA H A +  +T I+ F+      +N KD+AG
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            +PLH+A      + ++ LL +  + + +N+    P+H A   N+  +  +  +  +  N
Sbjct: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--N 131

Query: 141 VNQGGEHGRTALHFAA 156
            +    +  TA+H AA
Sbjct: 132 PDAKDHYEATAMHRAA 147



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 15/197 (7%)

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           D    T LH A      + +E+LLQ  V  +  ++   +P+H+A    +  +++      
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 137 SLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +   VN   ++G T LH+AA  + H++   +L    + + K   +     +H AA   + 
Sbjct: 97  A--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--HYEATAMHRAAAKGNL 152

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           + I + L +        +   ++ D EGN PLH A     ++  +L +  GA I  +  +
Sbjct: 153 KMIHILLYY--------KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204

Query: 256 LSTPVHLACAQGALDIV 272
             TP  L  A+G L ++
Sbjct: 205 EKTP--LQVAKGGLGLI 219



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +    LH A   G  + VE  L+ G  ++ +     +P+H+A + G  +IVK +    
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG-- 94

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++  
Sbjct: 95  ---KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHL 366
            + +H L+   A   ++D      LHL
Sbjct: 152 LKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           VN   + G + LH AA    D   K L+    A+      NG  P+H AA         +
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVM 124

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            L+ G              D+     +H A   G++K + + L   A  + Q  + +TP+
Sbjct: 125 LLEGGANPDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPL 176

Query: 261 HLACAQGALDIVKLM 275
           HLAC +  ++  KL+
Sbjct: 177 HLACDEERVEEAKLL 191



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 25/106 (23%), Positives = 49/106 (46%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S   D+ ++  L + +++   +  G T  H A+++N   I   +     + +AKD+  
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
            T +H A     L  I  LL     T++ + +   P+H+A +  +V
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 28/127 (22%), Positives = 50/127 (39%), Gaps = 2/127 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +  H A++     I+  +      +NA +  G TPLH A      +    LL+ 
Sbjct: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
                  +      +H A     + ++ +   YK+  N+      G T LH A   +   
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD--TEGNTPLHLACDEERVE 186

Query: 163 CAKILIT 169
            AK+L++
Sbjct: 187 EAKLLVS 193


>AK098479-1|BAC05314.1|  353|Homo sapiens protein ( Homo sapiens
           cDNA FLJ25613 fis, clone STM01546. ).
          Length = 353

 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 83/293 (28%), Positives = 132/293 (45%), Gaps = 30/293 (10%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D E   PLH+A + GD+  ++L L +G       H  S P        ++ I   + T  
Sbjct: 37  DQERRTPLHAAAYVGDVPILQLLLITGFL-----HTSSPP--------SIKIGNYIPT-- 81

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
                A + + D   + P+H AA   + +++  L+   +D+N  DK  ++PL +AA+   
Sbjct: 82  ----GANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRA 137

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT 399
            +    L  L + + + D + R+ LH  V + G LE                 LN  D  
Sbjct: 138 TKCAEALAPLLSSLNVADRSGRSALHHAV-HSGHLETVNLLLNKGAS------LNVCDKK 190

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
              PLH+A+  GH+  L+ L+  GA +  K+      LH AA  G+      LL      
Sbjct: 191 ERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE- 249

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMS 511
             I+E +  G T LHIA   G   V   L+N GA +++ ++ G  PLH+AA+S
Sbjct: 250 --IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVS 300



 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 77/265 (29%), Positives = 124/265 (46%), Gaps = 17/265 (6%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           +I NY I  G+++N  D    +PL  AA+    + +  L+   AD+  +D   +  LH+ 
Sbjct: 74  KIGNY-IPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA 132

Query: 368 VMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN 427
             N       A  C +     LL  LN  D +G S LH+A   GH+ ++  L+  GA +N
Sbjct: 133 AANR------ATKCAE-ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 185

Query: 428 LKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHL 487
           + +     PLH+AA  G      +LL +        +  G GL  LH A+  G   VV  
Sbjct: 186 VCDKKERQPLHWAAFLGHLE-VLKLLVARGADLGCKDRKGYGL--LHTAAASGQIEVVKY 242

Query: 488 LLNRGALLHRDHN-GRNPLHLAAMSGY-TKTIELLHSVHSHLLDQIDKDGNTSLHLATME 545
           LL  GA +   +  G   LH+A   G     IEL+++  +  ++Q +  G T LH+A + 
Sbjct: 243 LLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN--VNQPNDKGFTPLHVAAVS 300

Query: 546 -NKPSSIALLLSMGC-RLSYNNMDM 568
            N    + LL++ G    +YN +++
Sbjct: 301 TNGALCLELLVNNGAFYFNYNVIEL 325



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 13/238 (5%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A    + K + L L   A ++ +     TP+H+A A  A    + +  +      +
Sbjct: 95  PLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL-----S 149

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            L   D    + +H A    H E VN L+N+G+ +N  DK+ R PL  AA       +  
Sbjct: 150 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 209

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L+  GAD+  KD     +LH    + G++E      +   E      ++E +  G + LH
Sbjct: 210 LVARGADLGCKDRKGYGLLHTAAAS-GQIEVVKYLLRMGAE------IDEPNAFGNTALH 262

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
            A   G       L+  GA +N  N+   +PLH AA        C  L  + G F  N
Sbjct: 263 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA-VSTNGALCLELLVNNGAFYFN 319



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 60/197 (30%), Positives = 94/197 (47%), Gaps = 6/197 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N KD    +PLH A+   + + L  L+   A +N ++   ++PLH AA   R     + 
Sbjct: 85  VNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAA-NRATKCAEA 143

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
           L     +  +N +D  G + LH A   GH   V+LLLN+GA L+  D   R PLH AA  
Sbjct: 144 LAPLLSS--LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFL 201

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSA 570
           G+ + ++LL +  + L  + D+ G   LH A    +   +  LL MG  +   N    +A
Sbjct: 202 GHLEVLKLLVARGADLGCK-DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 260

Query: 571 IDYAIYYKFPEAALAMV 587
           +  A Y      A+ +V
Sbjct: 261 LHIACYLGQDAVAIELV 277



 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 63/240 (26%), Positives = 103/240 (42%), Gaps = 15/240 (6%)

Query: 33  YLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEA 92
           Y+   + +  +D       H+A+A  N  +L  +  ++ D+NA+D    TPLHVA  N A
Sbjct: 78  YIPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRA 137

Query: 93  LDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTAL 152
               E L       +V +   ++ +H A     +  + +     +  NV    E  R  L
Sbjct: 138 TKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE--RQPL 195

Query: 153 HFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTR 212
           H+AA   H    K+L+    A+       GY  +H AA +     ++  L+ G +     
Sbjct: 196 HWAAFLGHLEVLKLLVA-RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE----- 249

Query: 213 EQMISLYDNEGNVPLHSAVH-GGDIKAVELCLRSGAKISTQQHDLSTPVHLAC--AQGAL 269
              I   +  GN  LH A + G D  A+EL + +GA ++       TP+H+A     GAL
Sbjct: 250 ---IDEPNAFGNTALHIACYLGQDAVAIEL-VNAGANVNQPNDKGFTPLHVAAVSTNGAL 305



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 45/186 (24%), Positives = 79/186 (42%), Gaps = 13/186 (6%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+H AA N +++  E                +++ D  G   LH AVH G ++ V L L 
Sbjct: 128 PLHVAAANRATKCAEAL--------APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 179

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
            GA ++        P+H A   G L+++KL+       + A L   D +    +H AA  
Sbjct: 180 KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA-----RGADLGCKDRKGYGLLHTAAAS 234

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
              E+V YL+  G++I+  +    + L +A           L+  GA++   +      L
Sbjct: 235 GQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPL 294

Query: 365 HLVVMN 370
           H+  ++
Sbjct: 295 HVAAVS 300



 Score = 53.2 bits (122), Expect = 5e-06
 Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 13/230 (5%)

Query: 19  QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDN 78
           +AA S N +  + L L+  + +  RD   +T  H A+A   T     +      LN  D 
Sbjct: 98  RAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADR 156

Query: 79  AGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSL 138
           +G + LH AV +  L+ +  LL +    +V ++K + P+H A  L  + VL++     + 
Sbjct: 157 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA- 215

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
            ++      G   LH AA        K L+  + AE  +P   G   +H A         
Sbjct: 216 -DLGCKDRKGYGLLHTAAASGQIEVVKYLLR-MGAEIDEPNAFGNTALHIACYLGQDAVA 273

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLH-SAVHGGDIKAVELCLRSGA 247
              +  G          ++  +++G  PLH +AV       +EL + +GA
Sbjct: 274 IELVNAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 315


>AB009619-1|BAA33215.1|  226|Homo sapiens 26S proteasome subunit p28
           protein.
          Length = 226

 Score = 86.6 bits (205), Expect = 5e-16
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 13/209 (6%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL    ++   T    LH+A   GH   +E L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTA---LHWACSAGHTEIVEFL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           ++LG  +N K++   SPLH AA  GR      LL   KG   +N  +  G TPLH A+ +
Sbjct: 60  LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--GKGA-QVNAVNQNGCTPLHYAASK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
               +  +LL  GA    +DH     +H AA  G  K I +L    +    Q D +GNT 
Sbjct: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTP 175

Query: 539 LHLATMENKPSSIALLLSMGCRLSYNNMD 567
           LHLA  E +     LL+S G  +   N +
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIENKE 204



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/158 (32%), Positives = 82/158 (51%), Gaps = 8/158 (5%)

Query: 389 LLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGR 445
           LLQL   +N+KD+ G SPLH A+  G    ++ L+  GA +N  N N  +PLH+AA   R
Sbjct: 59  LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118

Query: 446 FHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
              A  LL+        +  D    T +H A+ +G+ +++H+LL   A  + +D  G  P
Sbjct: 119 HEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           LHLA      +  +LL S  + +  + +K+  T L +A
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIE-NKEEKTPLQVA 212



 Score = 62.5 bits (145), Expect = 9e-09
 Identities = 56/205 (27%), Positives = 92/205 (44%), Gaps = 17/205 (8%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E+   ++ + S     D++ R+ L  A S      V  L++LG  +  KD    + LH+ 
Sbjct: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80

Query: 368 VMNGGRLEDFAASCKDHCEKSLL---QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGA 424
                     A++ +D   K+LL     +N  +  GC+PLHYA+ +        L+  GA
Sbjct: 81  ----------ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130

Query: 425 CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRV 484
             + K++   + +H AA  G       LL     T   N  D EG TPLH+A  E     
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST---NIQDTEGNTPLHLACDEERVEE 187

Query: 485 VHLLLNRGALLH-RDHNGRNPLHLA 508
             LL+++GA ++  +   + PL +A
Sbjct: 188 AKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    T +H A    H EIV +L+  G  +N  D    SPL +AAS      V  L+
Sbjct: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCS 402
             GA +   + N    LH           +AAS K+  E +++ L      + KD+   +
Sbjct: 94  GKGAQVNAVNQNGCTPLH-----------YAAS-KNRHEIAVMLLEGGANPDAKDHYEAT 141

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            +H A+ +G+++ +  L+   A  N+++    +PLH A    R   A  L+      +I 
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201

Query: 463 NESDGEGLTPLHIA 476
           N+   E  TPL +A
Sbjct: 202 NK---EEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 14/194 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +  RTALH+A    H    + L+  L        + G+ P+H AA       ++  L  G
Sbjct: 38  QDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
            Q        ++  +  G  PLH A      +   + L  GA    + H  +T +H A A
Sbjct: 97  AQ--------VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G L ++ ++   +     A     D +  TP+H A   +  E    L+++G+ I   +K
Sbjct: 149 KGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203

Query: 326 ERRSPLLLAASRAG 339
           E ++PL +A    G
Sbjct: 204 EEKTPLQVAKGGLG 217



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 2/136 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D   RTA H A +  +T I+ F+      +N KD+AG
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            +PLH+A      + ++ LL +  + + +N+    P+H A   N+  +  +  +  +  N
Sbjct: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--N 131

Query: 141 VNQGGEHGRTALHFAA 156
            +    +  TA+H AA
Sbjct: 132 PDAKDHYEATAMHRAA 147



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 15/197 (7%)

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           D    T LH A      + +E+LLQ  V  +  ++   +P+H+A    +  +++      
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 137 SLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +   VN   ++G T LH+AA  + H++   +L    + + K   +     +H AA   + 
Sbjct: 97  A--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--HYEATAMHRAAAKGNL 152

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           + I + L +        +   ++ D EGN PLH A     ++  +L +  GA I  +  +
Sbjct: 153 KMIHILLYY--------KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204

Query: 256 LSTPVHLACAQGALDIV 272
             TP  L  A+G L ++
Sbjct: 205 EKTP--LQVAKGGLGLI 219



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +    LH A   G  + VE  L+ G  ++ +     +P+H+A + G  +IVK +    
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG-- 94

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++  
Sbjct: 95  ---KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHL 366
            + +H L+   A   ++D      LHL
Sbjct: 152 LKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           VN   + G + LH AA    D   K L+    A+      NG  P+H AA         +
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVM 124

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            L+ G              D+     +H A   G++K + + L   A  + Q  + +TP+
Sbjct: 125 LLEGGANPDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPL 176

Query: 261 HLACAQGALDIVKLM 275
           HLAC +  ++  KL+
Sbjct: 177 HLACDEERVEEAKLL 191



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 25/106 (23%), Positives = 49/106 (46%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S   D+ ++  L + +++   +  G T  H A+++N   I   +     + +AKD+  
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
            T +H A     L  I  LL     T++ + +   P+H+A +  +V
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 28/127 (22%), Positives = 50/127 (39%), Gaps = 2/127 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +  H A++     I+  +      +NA +  G TPLH A      +    LL+ 
Sbjct: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
                  +      +H A     + ++ +   YK+  N+      G T LH A   +   
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD--TEGNTPLHLACDEERVE 186

Query: 163 CAKILIT 169
            AK+L++
Sbjct: 187 EAKLLVS 193


>BT019689-1|AAV38495.1|  226|Homo sapiens proteasome (prosome,
           macropain) 26S subunit, non-ATPase, 10 protein.
          Length = 226

 Score = 86.2 bits (204), Expect = 6e-16
 Identities = 70/209 (33%), Positives = 99/209 (47%), Gaps = 13/209 (6%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL    ++   T    LH+A   GH   +E L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTA---LHWACSAGHTEIVEFL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           ++LG  +N K++   SPLH AA  GR      LL   KG   +N  +  G TPLH A+ +
Sbjct: 60  LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--GKGA-QVNAVNQNGCTPLHYAASK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
               +  +LL  GA    +DH     +H AA  G  K I +L    +    Q D +GNT 
Sbjct: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTP 175

Query: 539 LHLATMENKPSSIALLLSMGCRLSYNNMD 567
           LHLA  E +     LL+S G  +   N +
Sbjct: 176 LHLACDEERVEEAKLLVSQGTSIYIENKE 204



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/158 (32%), Positives = 82/158 (51%), Gaps = 8/158 (5%)

Query: 389 LLQL---LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGR 445
           LLQL   +N+KD+ G SPLH A+  G    ++ L+  GA +N  N N  +PLH+AA   R
Sbjct: 59  LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118

Query: 446 FHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
              A  LL+        +  D    T +H A+ +G+ +++H+LL   A  + +D  G  P
Sbjct: 119 HEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           LHLA      +  +LL S  + +  + +K+  T L +A
Sbjct: 176 LHLACDEERVEEAKLLVSQGTSIYIE-NKEEKTPLQVA 212



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    T +H A    H EIV +L+  G  +N  D    SPL +AAS      V  L+
Sbjct: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNTGCS 402
             GA +   + N    LH           +AAS K+  E +++ L      + KD+   +
Sbjct: 94  GKGAQVNAVNQNGCTPLH-----------YAAS-KNRHEIAVMLLEGGANPDAKDHYEAT 141

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            +H A+ +G+++ +  L+   A  N+++    +PLH A    R   A  L+      +I 
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGTSIYIE 201

Query: 463 NESDGEGLTPLHIA 476
           N+   E  TPL +A
Sbjct: 202 NK---EEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 55/205 (26%), Positives = 91/205 (44%), Gaps = 17/205 (8%)

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLV 367
           E+   ++ + S     D++ R+ L  A S      V  L++LG  +  KD    + LH+ 
Sbjct: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80

Query: 368 VMNGGRLEDFAASCKDHCEKSLL---QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGA 424
                     A++ +D   K+LL     +N  +  GC+PLHYA+ +        L+  GA
Sbjct: 81  ----------ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130

Query: 425 CINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRV 484
             + K++   + +H AA  G       LL     T   N  D EG TPLH+A  E     
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST---NIQDTEGNTPLHLACDEERVEE 187

Query: 485 VHLLLNRGALLH-RDHNGRNPLHLA 508
             LL+++G  ++  +   + PL +A
Sbjct: 188 AKLLVSQGTSIYIENKEEKTPLQVA 212



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 14/194 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +  RTALH+A    H    + L+  L        + G+ P+H AA       ++  L  G
Sbjct: 38  QDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
            Q        ++  +  G  PLH A      +   + L  GA    + H  +T +H A A
Sbjct: 97  AQ--------VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK 325
           +G L ++ ++   +     A     D +  TP+H A   +  E    L+++G+ I   +K
Sbjct: 149 KGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGTSIYIENK 203

Query: 326 ERRSPLLLAASRAG 339
           E ++PL +A    G
Sbjct: 204 EEKTPLQVAKGGLG 217



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 2/136 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D   RTA H A +  +T I+ F+      +N KD+AG
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            +PLH+A      + ++ LL +  + + +N+    P+H A   N+  +  +  +  +  N
Sbjct: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--N 131

Query: 141 VNQGGEHGRTALHFAA 156
            +    +  TA+H AA
Sbjct: 132 PDAKDHYEATAMHRAA 147



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D +    LH A   G  + VE  L+ G  ++ +     +P+H+A + G  +IVK +    
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG-- 94

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++  
Sbjct: 95  ---KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHL 366
            + +H L+   A   ++D      LHL
Sbjct: 152 LKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGTSIYIENKEEKTPLQVA 212



 Score = 55.6 bits (128), Expect = 1e-06
 Identities = 46/197 (23%), Positives = 87/197 (44%), Gaps = 15/197 (7%)

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           D    T LH A      + +E+LLQ  V  +  ++   +P+H+A    +  +++      
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 137 SLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
           +   VN   ++G T LH+AA  + H++   +L    + + K   +     +H AA   + 
Sbjct: 97  A--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--HYEATAMHRAAAKGNL 152

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHD 255
           + I + L +        +   ++ D EGN PLH A     ++  +L +  G  I  +  +
Sbjct: 153 KMIHILLYY--------KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGTSIYIENKE 204

Query: 256 LSTPVHLACAQGALDIV 272
             TP  L  A+G L ++
Sbjct: 205 EKTP--LQVAKGGLGLI 219



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEV 200
           VN   + G + LH AA    D   K L+    A+      NG  P+H AA         +
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVM 124

Query: 201 FLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPV 260
            L+ G              D+     +H A   G++K + + L   A  + Q  + +TP+
Sbjct: 125 LLEGGANPDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPL 176

Query: 261 HLACAQGALDIVKLM 275
           HLAC +  ++  KL+
Sbjct: 177 HLACDEERVEEAKLL 191



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 25/106 (23%), Positives = 49/106 (46%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S   D+ ++  L + +++   +  G T  H A+++N   I   +     + +AKD+  
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV 126
            T +H A     L  I  LL     T++ + +   P+H+A +  +V
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185



 Score = 41.9 bits (94), Expect = 0.013
 Identities = 28/127 (22%), Positives = 50/127 (39%), Gaps = 2/127 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G +  H A++     I+  +      +NA +  G TPLH A      +    LL+ 
Sbjct: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
                  +      +H A     + ++ +   YK+  N+      G T LH A   +   
Sbjct: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD--TEGNTPLHLACDEERVE 186

Query: 163 CAKILIT 169
            AK+L++
Sbjct: 187 EAKLLVS 193


>AK222595-1|BAD96315.1|  518|Homo sapiens ankyrin repeat and SOCS
           box-containing protein 3 isoform a variant protein.
          Length = 518

 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 70/293 (23%), Positives = 132/293 (45%), Gaps = 12/293 (4%)

Query: 230 AVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTS 289
           A   G++K +   L+ G  +    +    P+H A    +++ ++++      E +  + +
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76

Query: 290 CDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRL 349
              +    +H AA   H +IV  L+  G+D N    E  +PL LA        +  L++ 
Sbjct: 77  --FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134

Query: 350 GADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASR 409
           GA++      S ++     ++    +D A   K    K   +    +D+ G +PL  A++
Sbjct: 135 GANVN----GSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKEC--QDDFGITPLFVAAQ 188

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGE 468
            G + SL  LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++  
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDS 246

Query: 469 GLTPLHIASREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
              P+H A++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 247 WQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 79/308 (25%), Positives = 128/308 (41%), Gaps = 31/308 (10%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLN---AK 76
           AA  GNV   +R  L +   + V D RG    H+A+  N+   L  + N     N    K
Sbjct: 17  AAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
              G   LH+A        ++ LL+   + +    +   P+ +A E  ++ VL++  ++ 
Sbjct: 76  TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135

Query: 137 SLFNVNQGGEH---GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN--GYYPIHEAAK 191
           +  NVN  G H   G  +LH A+  D+    K+L   L     K C +  G  P+  AA+
Sbjct: 136 A--NVN--GSHSMCGWNSLHQASFQDNAEIIKLL---LRKGANKECQDDFGITPLFVAAQ 188

Query: 192 NASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA--KI 249
                ++ + +  G    C   Q +     +   PL  A   G  K VEL L SGA   +
Sbjct: 189 YGKLESLSILISSGANVNC---QAL-----DKATPLFIAAQEGHTKCVELLLSSGADPDL 240

Query: 250 STQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEI 309
              +     P+H A   G   I+ L+    P    AC T   + K++P++ A    H + 
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLI---PLTNRACDTG--LNKVSPVYSAVFGGHEDC 295

Query: 310 VNYLINEG 317
           +  L+  G
Sbjct: 296 LEILLRNG 303



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 46/159 (28%), Positives = 77/159 (48%), Gaps = 1/159 (0%)

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTF 460
           CS +  A+REG+++ L  L++ G  +++ +N    P+H AA +        L+++D    
Sbjct: 11  CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIEL 519
            I     EG   LH+A+ +GH ++V +LL  GA  +        PL LA  +G    + L
Sbjct: 71  YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           L    +++       G  SLH A+ ++    I LLL  G
Sbjct: 131 LLQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKG 169



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 85/327 (25%), Positives = 136/327 (41%), Gaps = 36/327 (11%)

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           T    + C   + +A     V VL+   K     +V+     G   +H AA H+   C +
Sbjct: 4   TEAYADTCST-VGLAAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQ 60

Query: 166 ILITDLDAE--WKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
           +LI    +E   K     G+  +H AA     + +++ L+ G     T          E 
Sbjct: 61  MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL--------EE 112

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPK 281
             PL  AV  G I  + L L+ GA ++   H +     +H A  Q   +I+KL+      
Sbjct: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMCGWNSLHQASFQDNAEIIKLLL----- 166

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
            K A     D   +TP+  AA +   E ++ LI+ G+++N    ++ +PL +AA     +
Sbjct: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNT 399
            V  L+  GAD  L   N          +  +L   AA+   H +    L+ L N   +T
Sbjct: 227 CVELLLSSGADPDLY-CNE---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDT 276

Query: 400 G---CSPLHYASREGHIRSLENLIRLG 423
           G    SP++ A   GH   LE L+R G
Sbjct: 277 GLNKVSPVYSAVFGGHEDCLEILLRNG 303



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 73/314 (23%), Positives = 131/314 (41%), Gaps = 24/314 (7%)

Query: 19  QAAESGNVDDFMRLYLSEPSR--LAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           +AA   +V+    L  ++ S   + ++   G  A H A+++ +  I+  +     D NA 
Sbjct: 49  EAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNAT 108

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC-QAPIHMATELNKVSVLQVFAKY 135
                TPL +AVEN  +D +  LLQ     +  +  C    +H A+  +   ++++  + 
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRK 168

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
            +  N     + G T L  AA +       ILI+   A       +   P+  AA+   +
Sbjct: 169 GA--NKECQDDFGITPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHT 225

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGN--VPLHSAVHGGDIKAVELCLRSGAKISTQQ 253
           + +E+ L  G            LY NE +  +P+H+A   G  K ++L +    +     
Sbjct: 226 KCVELLLSSGADP--------DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277

Query: 254 HDLSTPVHLACAQGALDIVKLMF-TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE---I 309
            +  +PV+ A   G  D ++++       +  ACL        +P+ C A     E   I
Sbjct: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV---FGFSSPV-CMAFQKDCEFFGI 333

Query: 310 VNYLINEGSDINPL 323
           VN L+  G+ IN L
Sbjct: 334 VNILLKYGAQINEL 347



 Score = 41.5 bits (93), Expect = 0.017
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKE 173

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 174 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230

Query: 520 LHS 522
           L S
Sbjct: 231 LLS 233


>AB032965-1|BAA86453.1| 1124|Homo sapiens KIAA1139 protein protein.
          Length = 1124

 Score = 85.8 bits (203), Expect = 8e-16
 Identities = 64/215 (29%), Positives = 104/215 (48%), Gaps = 15/215 (6%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G  PLHYA+ +G +  +  L+R  A +N  + + + PLH AA+YG +  +  LL   
Sbjct: 1   DSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 60

Query: 457 KGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG---ALLHR------DHNGRNPLHL 507
               ++N++     TPL +A   G  +V  LLLN     ALL        D N   PLHL
Sbjct: 61  SNPCLVNKAK---KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHL 117

Query: 508 AAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNM 566
           AA +G+ + I  L      +  Q  K G T+LH A +  K   + LLL  G  ++  N  
Sbjct: 118 AAKNGHREVIRQLLRAGIEINRQ-TKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTY 175

Query: 567 DMSAIDYAIYYKFPEAALAMVTHEQRAKEVMALRS 601
           + +A+D    +   +A+  +    + A  ++ +R+
Sbjct: 176 NQTALDIVNQFTTSQASREIKQLLREASGILKVRA 210



 Score = 65.3 bits (152), Expect = 1e-09
 Identities = 42/133 (31%), Positives = 64/133 (48%), Gaps = 5/133 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N     G  PLH A++ GH    E L++  +   L N   ++PL  A  +GR   A  L
Sbjct: 30  VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 89

Query: 453 LDSDKGTFII-----NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHL 507
           L+S     ++     +  D    TPLH+A++ GH  V+  LL  G  ++R       LH 
Sbjct: 90  LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHE 149

Query: 508 AAMSGYTKTIELL 520
           AA+ G T+ + LL
Sbjct: 150 AALYGKTEVVRLL 162



 Score = 59.7 bits (138), Expect = 6e-08
 Identities = 44/160 (27%), Positives = 70/160 (43%), Gaps = 14/160 (8%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D+ G  PLH A   G ++ V L LR+ A ++    D   P+HLA   G  ++ +++   Q
Sbjct: 1   DSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 60

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN--------EGSDINPLDKERRSPL 331
               + CL   +  K TP+  A  F   ++   L+N        EG   +P D    +PL
Sbjct: 61  ---SNPCLV--NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPL 115

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
            LAA       +  L+R G +I  +   +   LH   + G
Sbjct: 116 HLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYG 154



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 37/168 (22%), Positives = 67/168 (39%), Gaps = 8/168 (4%)

Query: 44  DGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQH 103
           D  G    H A+ +     +  +   +  +NA    G  PLH+A +    +  E LLQ  
Sbjct: 1   DSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 60

Query: 104 VETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQG------GEHGRTALHFAAI 157
               ++N+  + P+ +A E  ++ V Q+         + +G        +  T LH AA 
Sbjct: 61  SNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAK 120

Query: 158 HDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           + H    + L+     E  +    G   +HEAA    +  + + L+ G
Sbjct: 121 NGHREVIRQLLR-AGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGG 166



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 42/183 (22%), Positives = 73/183 (39%), Gaps = 23/183 (12%)

Query: 147 HGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGE 206
           +G   LH+AA        ++L+    A       +G  P+H AA+       E+ LQ  +
Sbjct: 3   NGMRPLHYAAWQGRLEPVRLLLR-ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQH-Q 60

Query: 207 QRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL--------ST 258
              C       L +     PL  A   G +K  +L L S   ++  + +         +T
Sbjct: 61  SNPC-------LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTT 113

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
           P+HLA   G  ++++ +     +      T       T +H AA++   E+V  L+  G 
Sbjct: 114 PLHLAAKNGHREVIRQLLRAGIEINRQTKTG------TALHEAALYGKTEVVRLLLEGGV 167

Query: 319 DIN 321
           D+N
Sbjct: 168 DVN 170


>DQ822519-1|ABG46944.1|  835|Homo sapiens TNNI3 interacting kinase
           protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>BX470253-1|CAI16293.1|  835|Homo sapiens TNNI3 interacting kinase
           protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>BC117262-1|AAI17263.1|  835|Homo sapiens TNNI3 interacting kinase
           protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>BC113539-1|AAI13540.1|  835|Homo sapiens TNNI3 interacting kinase
           protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>AY303691-1|AAP72030.1|  835|Homo sapiens cardiac ankyrin repeat
           kinase protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>AJ278120-1|CAB92314.1| 1101|Homo sapiens putative ankyrin-repeat
           containing protein protein.
          Length = 1101

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 96/334 (28%), Positives = 139/334 (41%), Gaps = 32/334 (9%)

Query: 239 VELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPI 298
           V L L  GA +        TP+  A A G L IV L+   + K  H      D      +
Sbjct: 2   VALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL-----DKNGQCAL 56

Query: 299 HCAAMFDHPEIVNYLIN-----EGSDINPLDKER--RSPLLLAASRAGWRTVHTLIRLGA 351
             AA+  H E+V +LI       G       K    +  L+ AAS      V  L+ L  
Sbjct: 57  VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 116

Query: 352 ----DIQLKDINSRNVLH----LVVMNG-GRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
               +++   INS + L     L    G G+LE     C+   E+     + + +  G  
Sbjct: 117 KDEEEVERAQINSFDSLWGETALTAAAGRGKLE----VCRLLLEQGAA--VAQPNRRGAV 170

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           PL    R+GH + ++ L+  GA +N+ +    +PL  AA  G   T   LL       ++
Sbjct: 171 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM 230

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLH 521
              D EGLT L  A  +GH  VV  L++ GA   H D NGR PL LAA  G  + ++ L 
Sbjct: 231 ---DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 287

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
             H  +++ +D  G   L  A      S +  LL
Sbjct: 288 D-HGAMIEHVDYSGMRPLDRAVGCPNTSVVVTLL 320



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 89/351 (25%), Positives = 145/351 (41%), Gaps = 30/351 (8%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM----FTM 278
           G  PL  A   G +  V L  +  AK+     +    +  A  +G L++VK +    +TM
Sbjct: 19  GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 78

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN---------EGSDINPLDKE-RR 328
             +++     S  +Q+   +  AA   + EIV+YL++         E + IN  D     
Sbjct: 79  AGQQQGVFKKSHAIQQA--LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGE 136

Query: 329 SPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEK 387
           + L  AA R        L+  GA +   +      L   V  G  ++ D   +   H   
Sbjct: 137 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT---HGAD 193

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
                +N  D  G +PL  A+ EGH+ +++ L+  GA I L +    + L +A   G   
Sbjct: 194 -----VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLS 248

Query: 448 TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLH 506
               L+D+   T   + +D  G TPL +A+  G   VV  L++ GA++ H D++G  PL 
Sbjct: 249 VVRSLVDNGAAT---DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLD 305

Query: 507 LAAMSGYTK-TIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
            A     T   + LL       L  +          A   +KP  + +LLS
Sbjct: 306 RAVGCPNTSVVVTLLKKRSQDRLSDVXSRPRGPATWAMAPSKPDIMIILLS 356



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 54/215 (25%), Positives = 91/215 (42%), Gaps = 16/215 (7%)

Query: 148 GRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGE 206
           G TAL  AA     ++C   L+ +  A   +P   G  P+    +    + +++ L  G 
Sbjct: 135 GETALTAAAGRGKLEVCR--LLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 192

Query: 207 QRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQ 266
                    +++ D +G  PL  A   G +  V+  L  GA I+    +  T +  AC +
Sbjct: 193 D--------VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 244

Query: 267 GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE 326
           G L +V+ +        HA     D    TP+  AA +   E+V +L++ G+ I  +D  
Sbjct: 245 GHLSVVRSLVDNGAATDHA-----DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS 299

Query: 327 RRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSR 361
              PL  A        V TL++  +  +L D+ SR
Sbjct: 300 GMRPLDRAVGCPNTSVVVTLLKKRSQDRLSDVXSR 334



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 72/293 (24%), Positives = 118/293 (40%), Gaps = 16/293 (5%)

Query: 295 MTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG---A 351
           +TP+  AA   +  IV  L  + + ++ LDK  +  L+ AA R     V  LI+     A
Sbjct: 20  LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA 79

Query: 352 DIQLKDINSRNVLHLVVMNGGRL--EDFAASCKDHCEKSLLQL----LNEKDNT-GCSPL 404
             Q       + +   ++    +   +  +   D  EK   ++    +N  D+  G + L
Sbjct: 80  GQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETAL 139

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
             A+  G +     L+  GA +   N     PL    R G +     LL        +N 
Sbjct: 140 TAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD---VNM 196

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSV 523
           +D +G TPL +A+ EGH   V  LL +GA +   D  G   L  A + G+   +  L   
Sbjct: 197 ADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD- 255

Query: 524 HSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSY-NNMDMSAIDYAI 575
           +    D  DK+G T L LA        +  L+  G  + + +   M  +D A+
Sbjct: 256 NGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAV 308



 Score = 60.9 bits (141), Expect = 3e-08
 Identities = 46/158 (29%), Positives = 80/158 (50%), Gaps = 6/158 (3%)

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           E+ L  AA  G+    C+LL  ++G  +  + +  G  PL    R+GH ++V LLL  GA
Sbjct: 136 ETALTAAAGRGKLEV-CRLL-LEQGAAVA-QPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 192

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
            ++  D  GR PL +AA  G+  T++ L +  + +   +DK+G T+L  A ++   S + 
Sbjct: 193 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA-LMDKEGLTALSWACLKGHLSVVR 251

Query: 553 LLLSMGCRLSYNNMD-MSAIDYAIYYKFPEAALAMVTH 589
            L+  G    + + +  + +D A +Y   E    +V H
Sbjct: 252 SLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 289



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 5/149 (3%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           +  G VPL S V  G  + V+L L  GA ++       TP+ +A ++G L  V  +    
Sbjct: 165 NRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLA-- 222

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              + A +   D + +T +  A +  H  +V  L++ G+  +  DK  R+PL LAA    
Sbjct: 223 ---QGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGD 279

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVV 368
              V  L+  GA I+  D +    L   V
Sbjct: 280 AEVVQFLVDHGAMIEHVDYSGMRPLDRAV 308



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/139 (22%), Positives = 62/139 (44%), Gaps = 3/139 (2%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G ++   RL L + + +A  + RG         + +  I+  +  +  D+N  D  
Sbjct: 142 AAGRGKLE-VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ 200

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL +A     L  +++LL Q    ++++++    +  A     +SV++      +  
Sbjct: 201 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA- 259

Query: 140 NVNQGGEHGRTALHFAAIH 158
             +   ++GRT L  AA +
Sbjct: 260 -TDHADKNGRTPLDLAAFY 277



 Score = 36.7 bits (81), Expect = 0.49
 Identities = 63/294 (21%), Positives = 109/294 (37%), Gaps = 21/294 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G TA   A+ R    +   +      +   +  G  PL   V       ++ LL    + 
Sbjct: 135 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 194

Query: 107 SVLNEKCQAPIHMATELNKVSVLQ-VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           ++ +++ + P+ MA     +  +  + A+  S+  ++   + G TAL +A +  H    +
Sbjct: 195 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMD---KEGLTALSWACLKGHLSVVR 251

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            L+ D  A       NG  P+  AA    +  ++  +  G         MI   D  G  
Sbjct: 252 SLV-DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG--------AMIEHVDYSGMR 302

Query: 226 PLHSAVHGGDIKAVELCL--RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEK 283
           PL  AV   +   V   L  RS  ++S        P   A A    DI+ ++ +   KE 
Sbjct: 303 PLDRAVGCPNTSVVVTLLKKRSQDRLSDVXSRPRGPATWAMAPSKPDIMIILLSKLMKEG 362

Query: 284 HACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASR 337
                   V++    +  A+   P         G D+ P  +E +  LLL  SR
Sbjct: 363 DMFYKKGKVKEAAQRYQYALKKFPR-----EGFGEDLKPF-RELKVSLLLNLSR 410


>AF116826-1|AAD29632.1|  835|Homo sapiens putative protein-tyrosine
           kinase protein.
          Length = 835

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 117

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 178 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 236 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 289

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 345

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 346 SACYHGHIRLVQFLLDNGADMN 367



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 157

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 158 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 209

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 210 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 266

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 322

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 323 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 16/293 (5%)

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG    +   +  G + S    +  T +HLA  +   +++  +         A +     
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-----HSGADIQQVGY 132

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
             +T +H A +  H E  + L+  G+++N  D    +PL +AA     +    L++ GAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 353 IQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           + +        LHL    G     F    K   E+     +N +DN    PLH+ SR GH
Sbjct: 193 VNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247

Query: 413 IRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              ++ L++  L    ++ N   ++PLH A   G+F  A +++    GT  + + +    
Sbjct: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKENIFSE 306

Query: 471 TPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T  H A   G +  +V  LL++    + H+  +G   LH A   G+ + ++ L
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFL 359



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 163 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 212

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 213 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 269

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 327

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 117

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 118 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 576 YY 577
           YY
Sbjct: 176 YY 177


>AB208941-1|BAD92178.1|  941|Homo sapiens TNNI3 interacting kinase
           variant protein.
          Length = 941

 Score = 85.4 bits (202), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 164 VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 223

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 224 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 283

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 284 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 341

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 342 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 395

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 396 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 451

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 452 SACYHGHIRLVQFLLDNGADMN 473



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 206 NGFTALHLAVYKDNAELITSLLHSGADIQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 263

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 264 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 315

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 316 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 372

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 373 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 428

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 429 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 474



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 84/365 (23%), Positives = 151/365 (41%), Gaps = 23/365 (6%)

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKN----ASSRTIEVFLQWGEQRGCTREQMISLYDN 221
           IL+   D EWKK  +  Y    E  ++          E+   +G     ++  +    +N
Sbjct: 114 ILLIHSD-EWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTEN 172

Query: 222 EGNVPLH-SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
            G   LH   + GG    +   +  G + S    +  T +HLA  +   +++  +     
Sbjct: 173 -GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL---- 227

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGW 340
               A +       +T +H A +  H E  + L+  G+++N  D    +PL +AA     
Sbjct: 228 -HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 286

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
           +    L++ GAD+ +        LHL    G     F    K   E+     +N +DN  
Sbjct: 287 QVTRLLLKFGADVNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNED 341

Query: 401 CSPLHYASREGHIRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
             PLH+ SR GH   ++ L++  L    ++ N   ++PLH A   G+F  A +++    G
Sbjct: 342 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SG 400

Query: 459 TFIINESDGEGLTPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTK 515
           T  + + +    T  H A   G +  +V  LL++    + H+  +G   LH A   G+ +
Sbjct: 401 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 460

Query: 516 TIELL 520
            ++ L
Sbjct: 461 LVQFL 465



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 71/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 209 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 268

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 269 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 318

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 319 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 375

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 376 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 433

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 434 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 480



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 166 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 223

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 224 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 281

Query: 576 YY 577
           YY
Sbjct: 282 YY 283


>BC127127-1|AAI27128.1|  627|Homo sapiens ankyrin repeat and KH
           domain containing 1 protein.
          Length = 627

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 326

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 327 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 379

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 434

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 544

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468


>BC117677-1|AAI17678.1|  627|Homo sapiens ankyrin repeat and KH
           domain containing 1 protein.
          Length = 627

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 326

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 327 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 379

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 434

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 544

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468


>BC034982-1|AAH34982.1|  909|Homo sapiens HECT domain and ankyrin
           repeat containing, E3 ubiquitin protein ligase 1
           protein.
          Length = 909

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 17/230 (7%)

Query: 306 HPEIVNYLINEGSDIN-PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           H  +   L N   D+N    + +RS L +AA+      +  L++ GA+   +DI+    L
Sbjct: 43  HRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL 102

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           HL   NG +           C   LL+    +N  +N G + +H+ +  G    L +L++
Sbjct: 103 HLAARNGQK----------KCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQ 152

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
             + +++++   ++ LH A + G   T   LLDS      IN  +  G TPL+ A   G 
Sbjct: 153 HVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGAD---INRPNVSGATPLYFACSHGQ 209

Query: 482 TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
                +LL RGA    D NG  PL L    GY +T E+L   H  L   I
Sbjct: 210 RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTI 259



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 52/198 (26%), Positives = 92/198 (46%), Gaps = 15/198 (7%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K + +H AA     E +  L+ +G++ N  D    +PL LAA     + +  L+   AD+
Sbjct: 65  KRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADV 124

Query: 354 QLKDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
            + +      +H + +NG    L D      D         ++ +D  G + LH A + G
Sbjct: 125 NICNNEGLTAIHWLAVNGRTELLHDLVQHVSD---------VDVEDAMGQTALHVACQNG 175

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
           H  +++ L+  GA IN  N +  +PL+FA  +G+  TA Q+L      ++    D  G+T
Sbjct: 176 HKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTA-QILLLRGAKYL---PDKNGVT 231

Query: 472 PLHIASREGHTRVVHLLL 489
           PL +  + G+     +L+
Sbjct: 232 PLDLCVQGGYGETCEVLI 249



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 45/135 (33%), Positives = 67/135 (49%), Gaps = 9/135 (6%)

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           S LH AA  G     C +L   KG    N  D  G TPLH+A+R G  + +  LL   A 
Sbjct: 67  SLLHIAANCGSVE--CLVLLLKKGANP-NYQDISGCTPLHLAARNGQKKCMSKLLEYSAD 123

Query: 495 LHRDHN-GRNPLHLAAMSGYTKTIELLHSVHSHL--LDQIDKDGNTSLHLATMENKPSSI 551
           ++  +N G   +H  A++G T   ELLH +  H+  +D  D  G T+LH+A      +++
Sbjct: 124 VNICNNEGLTAIHWLAVNGRT---ELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTV 180

Query: 552 ALLLSMGCRLSYNNM 566
             LL  G  ++  N+
Sbjct: 181 QCLLDSGADINRPNV 195



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 53/215 (24%), Positives = 89/215 (41%), Gaps = 5/215 (2%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           +V  S    AA  G+V+  + L L + +    +D  G T  H A+       +  +  Y+
Sbjct: 63  RVKRSLLHIAANCGSVECLV-LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 121

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+N  +N G T +H    N   + +  L+Q   +  V +   Q  +H+A +    + +Q
Sbjct: 122 ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQ 181

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
                 S  ++N+    G T L+FA  H     A+IL+  L      P  NG  P+    
Sbjct: 182 CL--LDSGADINRPNVSGATPLYFACSHGQRDTAQILL--LRGAKYLPDKNGVTPLDLCV 237

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +     T EV +Q+  +   T  QM    D   N+
Sbjct: 238 QGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENM 272



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 39/194 (20%), Positives = 83/194 (42%), Gaps = 14/194 (7%)

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G+++ + L+        +  ++ C     TP+H AA     + ++ L+   +D
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGC-----TPLHLAARNGQKKCMSKLLEYSAD 123

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           +N  + E  + +   A       +H L++  +D+ ++D   +  LH+   NG +      
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHK------ 177

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
                C       +N  + +G +PL++A   G  R    ++ L     L + N  +PL  
Sbjct: 178 -TTVQCLLDSGADINRPNVSGATPLYFACSHGQ-RDTAQILLLRGAKYLPDKNGVTPLDL 235

Query: 440 AARYGRFHTACQLL 453
             + G +   C++L
Sbjct: 236 CVQ-GGYGETCEVL 248



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 44/161 (27%), Positives = 65/161 (40%), Gaps = 15/161 (9%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEW 175
           +H+A     V  L +  K  +  N N     G T LH AA +    C +K+L    D   
Sbjct: 69  LHIAANCGSVECLVLLLKKGA--NPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126

Query: 176 KKPCNN-GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGG 234
              CNN G   IH  A N  +  +   +Q            + + D  G   LH A   G
Sbjct: 127 ---CNNEGLTAIHWLAVNGRTELLHDLVQHVSD--------VDVEDAMGQTALHVACQNG 175

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
               V+  L SGA I+      +TP++ AC+ G  D  +++
Sbjct: 176 HKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 216


>BC032865-1|AAH32865.1|  843|Homo sapiens TNNI3K protein protein.
          Length = 843

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 76/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 159 VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 218

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 219 TSLLHSGADVQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 279 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 337 HVPLHFCSRFGHHDIVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 390

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 391 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 446

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D+N
Sbjct: 447 SACYHGHIRLVQFLLDNGADMN 468



 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 75/287 (26%), Positives = 129/287 (44%), Gaps = 23/287 (8%)

Query: 147 HGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           +G TALH A   D+ +L   +L +  D +  +    G   +H A         +V LQ G
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSGADVQ--QVGYGGLTALHIATIAGHLEAADVLLQHG 258

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     +++ D     PLH A + G  +   L L+ GA ++        P+HLA A
Sbjct: 259 AN--------VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA 310

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINP--L 323
           +G L+I KL+  M+   K A + + D +   P+H  + F H +IV YL+    ++ P  +
Sbjct: 311 KGFLNIAKLL--MEEGSK-ADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVV 367

Query: 324 DKERRSPLLLAASRAGWRTVHTLIRLGADIQL--KDINSRNVLHLVVMNGGRLEDFAASC 381
           +    +PL LA     +     +I++     L  ++I S    H     G  ++      
Sbjct: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID----LV 423

Query: 382 KDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINL 428
           K   +++++ + N +   G + LH A   GHIR ++ L+  GA +NL
Sbjct: 424 KFLLDQNVINI-NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 84/365 (23%), Positives = 151/365 (41%), Gaps = 23/365 (6%)

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKN----ASSRTIEVFLQWGEQRGCTREQMISLYDN 221
           IL+   D EWKK  +  Y    E  ++          E+   +G     ++  +    +N
Sbjct: 109 ILLIHSD-EWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTEN 167

Query: 222 EGNVPLH-SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
            G   LH   + GG    +   +  G + S    +  T +HLA  +   +++  +     
Sbjct: 168 -GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL---- 222

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGW 340
               A +       +T +H A +  H E  + L+  G+++N  D    +PL +AA     
Sbjct: 223 -HSGADVQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 281

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
           +    L++ GAD+ +        LHL    G     F    K   E+     +N +DN  
Sbjct: 282 QVTRLLLKFGADVNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNED 336

Query: 401 CSPLHYASREGHIRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
             PLH+ SR GH   ++ L++  L    ++ N   ++PLH A   G+F  A +++    G
Sbjct: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SG 395

Query: 459 TFIINESDGEGLTPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTK 515
           T  + + +    T  H A   G +  +V  LL++    + H+  +G   LH A   G+ +
Sbjct: 396 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 455

Query: 516 TIELL 520
            ++ L
Sbjct: 456 LVQFL 460



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 70/287 (24%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+D+  +     + L +A           L++ GA++ +
Sbjct: 204 TALHLAVYKDNAELITSLLHSGADVQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 263

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 264 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 313

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 314 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY--- 370

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 371 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 428

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  ++    D S
Sbjct: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 475



 Score = 36.7 bits (81), Expect = 0.49
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 218

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 219 TSLLHSGAD--VQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276

Query: 576 YY 577
           YY
Sbjct: 277 YY 278


>BC009909-1|AAH09909.1|  627|Homo sapiens ankyrin repeat and KH
           domain containing 1 protein.
          Length = 627

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 326

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 327 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 211 EACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 379

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 434

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 544

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 68/257 (26%), Positives = 103/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++E   +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468


>BC009420-1|AAH09420.1|  616|Homo sapiens ankyrin repeat and KH
           domain containing 1 protein.
          Length = 616

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 315

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 316 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 547

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 220 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 279

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 280 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 335 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 388

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 389 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 448

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 449 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 505

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 506 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 550



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 200 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 259

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 260 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 316

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 368

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 423

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 424 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 484 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 533

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 534 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 579



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 385 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 442 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 494 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 545

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 210 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 268

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 269 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 323

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 324 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 381

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 440

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 441 ELAALLIERGANLEEVN 457


>BC004457-1|AAH04457.2|  627|Homo sapiens ankyrin repeat and KH
           domain containing 1 protein.
          Length = 627

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 326

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 327 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 379

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 434

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 544

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468


>AK022041-1|BAB13958.1|  435|Homo sapiens protein ( Homo sapiens
           cDNA FLJ11979 fis, clone HEMBB1001282, weakly similar to
           ANKYRIN R. ).
          Length = 435

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 77  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 134

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 135 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 191

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 192 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 251

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 252 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 311

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 312 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 366

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 367 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 407



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 39  VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 98

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 99  LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 153

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 154 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 207

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 208 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 267

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 268 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 324

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 325 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 369



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 19  EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 78

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 79  GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 135

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 136 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 187

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 188 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 242

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 243 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 302

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 303 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 352

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 353 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 398



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 84  LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 143

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 144 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 203

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 204 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 260

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 261 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 312

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 313 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 364

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 365 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 406



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 29  VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 87

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 88  SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 142

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 143 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 200

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 201 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 259

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 260 ELAALLIERGANLEEVN 276


>AF258557-1|AAG23760.1|  627|Homo sapiens PP2500 protein.
          Length = 627

 Score = 85.0 bits (201), Expect = 1e-15
 Identities = 97/341 (28%), Positives = 145/341 (42%), Gaps = 39/341 (11%)

Query: 221 NEGNV-PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           N+G++ PL +A  GG +  V+L L   A +++Q    +T +  ACA G +DIVK++    
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN-- 326

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKE-RRSPLLLAASRA 338
              + A +   +    TP+  AA   H E+   L++ G+ IN    E + S L LA  + 
Sbjct: 327 ---EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 339 GWRTVHTLIRLGADIQLKDINSRNVLHLVVMNG----GRL------------EDFA---- 378
               V  L+  GAD + K       L    M+G     RL            + F     
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 379 -ASCKDHCEKSLLQL-----LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNN 432
            A+C  H E + L +     L E ++ G +PL  A+REGH   +  L+  GA IN +   
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
            +      A  G F      L        +  S     TPL  AS+EGH  +V  LL  G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 493 ALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQID 532
           A +H     G   L  A  +G+T   ++L    + L  Q D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score = 79.8 bits (188), Expect = 5e-14
 Identities = 87/349 (24%), Positives = 146/349 (41%), Gaps = 21/349 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
           +++  + L    +     I+   +T L  A+ E     +  LL+ G  +
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASGANV 561



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 89/406 (21%), Positives = 161/406 (39%), Gaps = 29/406 (7%)

Query: 53  QASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
           +A +  + N +  + +    +N     G + L +A      +  + LL  H        K
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270

Query: 113 CQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDL 171
               P+  A+    + ++++   + +  +VN     G TAL +A         K+L+ + 
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDA--DVNSQSATGNTALTYACAGGFVDIVKVLLNE- 327

Query: 172 DAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNE-GNVPLHSA 230
            A  +    NG+ P+ EAA         V L  G          I+ + NE     L  A
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--------INTHSNEFKESALTLA 379

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC 290
            + G +  V   L +GA    +  ++ T +  AC  G +++ +L+      +  A +   
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL-----DSGAQVNMP 434

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
                +P+  AA   H E+   LI  G+++  ++ E  +PL+ AA       V  L+  G
Sbjct: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS-PLHYASR 409
           A+I  +   ++     +   GG  E      K   +  L          GCS PL  AS+
Sbjct: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL----------GCSTPLMEASQ 544

Query: 410 EGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           EGH+  ++ L+  GA ++      ++ L +A   G    A  LL +
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 74/342 (21%), Positives = 139/342 (40%), Gaps = 21/342 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            G++++       + L  A           L++ GAD+  ++
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468


>AL158217-11|CAI22163.1|  854|Homo sapiens espin protein.
          Length = 854

 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 7/174 (4%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACI-NLKNNNNESPLHFAARYGRFHTACQ 451
           + +KDN+G + LH A+R GH   +  L+  G        +    P+H+AA  G F +   
Sbjct: 97  VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156

Query: 452 LLDS-DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLA 508
           L++   +G   +N     G TPL++A +EGH  V   L+   GA  H R H+G  PLH A
Sbjct: 157 LVEHYPEG---VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAA 213

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
           A  G++  I  L S     L + DKDG T++H A        ++ LL  G  +S
Sbjct: 214 AQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS 267



 Score = 77.8 bits (183), Expect = 2e-13
 Identities = 77/290 (26%), Positives = 130/290 (44%), Gaps = 22/290 (7%)

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK-MTPIHCAAMFDHPEIVNYLINEG 317
           PVH A   G L  ++ +      E+ A   +   +   TP H A+   H   + +L+++G
Sbjct: 39  PVHHAARAGKLHCLRFLV-----EEAALPAAARARNGATPAHDASATGHLACLQWLLSQG 93

Query: 318 S-DINPLDKERRSPLLLAASRAGWRTVHTLIRLGA-DIQLKDINSRNVLHLVVMNGGRLE 375
              +   D    + L LAA       V+ L+  G  D           +H     G    
Sbjct: 94  GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKG---- 149

Query: 376 DFAAS--CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNN 432
           DF +     +H  + +    N +   G +PL+ A +EGH+   + L++  GA  + + ++
Sbjct: 150 DFPSLRLLVEHYPEGV----NAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD 205

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PLH AA+ G       L+     +  ++E D +G T +H A+  GHT+V+  LL  G
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVS--LSEQDKDGATAMHFAASRGHTKVLSWLLLHG 263

Query: 493 ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
             +  D  G  PLH AA +G  +  ++L  V+   LD  D+DG T+  L+
Sbjct: 264 GEISADLWGGTPLHDAAENGELECCQIL-VVNGAELDVRDRDGYTAADLS 312



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 67/258 (25%), Positives = 109/258 (42%), Gaps = 11/258 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAG-DLNAKDN 78
           AA +G +     L        A R   G T AH ASA  +   L ++ +  G  +  KDN
Sbjct: 43  AARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDN 102

Query: 79  AGNTPLHVAVENEALDAIEYLLQQ-HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           +G T LH+A      + + +LL     + +   +    PIH A        L++  ++  
Sbjct: 103 SGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYP 162

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
              VN   ++G T L+ A    H    + L+ +  A+     ++G  P+H AA+   S  
Sbjct: 163 -EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPV 221

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           I V+L       CT +  +S  D +G   +H A   G  K +   L  G +IS       
Sbjct: 222 I-VWLV-----SCT-DVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWG-G 273

Query: 258 TPVHLACAQGALDIVKLM 275
           TP+H A   G L+  +++
Sbjct: 274 TPLHDAAENGELECCQIL 291



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 79/317 (24%), Positives = 134/317 (42%), Gaps = 25/317 (7%)

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGA-KISTQQHDLSTPVHLACAQGALDIVKLM 275
           SL D    +P+H A   G +  +   +   A   + +  + +TP H A A G L  ++ +
Sbjct: 30  SLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWL 89

Query: 276 FTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLL 333
            +     +  C +   D    T +H AA F HPE+VN+L++  G D          P+  
Sbjct: 90  LS-----QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHY 144

Query: 334 AASRAGWRTVHTLIR---LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           AA++  + ++  L+     G + Q K  N    L+L     G LE         C     
Sbjct: 145 AAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQE-GHLE-VTQYLVQECGAD-- 198

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTA 449
              + + + G +PLH A++ GH   +  L+      ++ ++ +  + +HFAA  G     
Sbjct: 199 --PHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVL 256

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL    G      +D  G TPLH A+  G      +L+  GA L  RD +G     L+
Sbjct: 257 SWLL-LHGGEI---SADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312

Query: 509 AMSGYTKTIELLHSVHS 525
             +G++     L +V +
Sbjct: 313 DFNGHSHCTRYLRTVEN 329



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 5/153 (3%)

Query: 396 KDNTGCSPLHYASREGHIRSLENLIRLGAC-INLKNNNNESPLHFAARYGRFHTACQLLD 454
           +D     P+H+A+R G +  L  L+   A     +  N  +P H A+  G  H AC    
Sbjct: 32  RDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATG--HLACLQWL 89

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA--LLHRDHNGRNPLHLAAMSG 512
             +G   + + D  G T LH+A+R GH  VV+ LL+ G          G  P+H AA  G
Sbjct: 90  LSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKG 149

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATME 545
              ++ LL   +   ++   K+G T L+LA  E
Sbjct: 150 DFPSLRLLVEHYPEGVNAQTKNGATPLYLACQE 182



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 65/312 (20%), Positives = 117/312 (37%), Gaps = 17/312 (5%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF-INNYAGDLNAK 76
           +QAA  G +D    L+ +     ++RD       H A+     + L F +   A    A+
Sbjct: 7   LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQ-HVETSVLNEKCQAPIHMATELNKVSVLQVFAKY 135
              G TP H A     L  +++LL Q        +      +H+A       V+  +  +
Sbjct: 67  ARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVN-WLLH 125

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
               +     + G   +H+AA        ++L+            NG  P++ A +    
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKA-VELCLRSGAKISTQQH 254
              +  +Q      C  +     +D  G  PLH+A   G     V L   +   +S Q  
Sbjct: 186 EVTQYLVQ-----ECGADPHARAHD--GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDK 238

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D +T +H A ++G   ++  +        H    S D+   TP+H AA     E    L+
Sbjct: 239 DGATAMHFAASRGHTKVLSWLLL------HGGEISADLWGGTPLHDAAENGELECCQILV 292

Query: 315 NEGSDINPLDKE 326
             G++++  D++
Sbjct: 293 VNGAELDVRDRD 304



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 2/89 (2%)

Query: 472 PLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           P+H A+R G    +  L+   AL    R  NG  P H A+ +G+   ++ L S     + 
Sbjct: 39  PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
             D  G T LHLA     P  +  LL  G
Sbjct: 99  DKDNSGATVLHLAARFGHPEVVNWLLHHG 127


>AL031848-3|CAI19773.1|  854|Homo sapiens espin protein.
          Length = 854

 Score = 84.2 bits (199), Expect = 2e-15
 Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 7/174 (4%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACI-NLKNNNNESPLHFAARYGRFHTACQ 451
           + +KDN+G + LH A+R GH   +  L+  G        +    P+H+AA  G F +   
Sbjct: 97  VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156

Query: 452 LLDS-DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLA 508
           L++   +G   +N     G TPL++A +EGH  V   L+   GA  H R H+G  PLH A
Sbjct: 157 LVEHYPEG---VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAA 213

Query: 509 AMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
           A  G++  I  L S     L + DKDG T++H A        ++ LL  G  +S
Sbjct: 214 AQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS 267



 Score = 77.8 bits (183), Expect = 2e-13
 Identities = 77/290 (26%), Positives = 130/290 (44%), Gaps = 22/290 (7%)

Query: 259 PVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQK-MTPIHCAAMFDHPEIVNYLINEG 317
           PVH A   G L  ++ +      E+ A   +   +   TP H A+   H   + +L+++G
Sbjct: 39  PVHHAARAGKLHCLRFLV-----EEAALPAAARARNGATPAHDASATGHLACLQWLLSQG 93

Query: 318 S-DINPLDKERRSPLLLAASRAGWRTVHTLIRLGA-DIQLKDINSRNVLHLVVMNGGRLE 375
              +   D    + L LAA       V+ L+  G  D           +H     G    
Sbjct: 94  GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKG---- 149

Query: 376 DFAAS--CKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNN 432
           DF +     +H  + +    N +   G +PL+ A +EGH+   + L++  GA  + + ++
Sbjct: 150 DFPSLRLLVEHYPEGV----NAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD 205

Query: 433 NESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRG 492
             +PLH AA+ G       L+     +  ++E D +G T +H A+  GHT+V+  LL  G
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVS--LSEQDKDGATAMHFAASRGHTKVLSWLLLHG 263

Query: 493 ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
             +  D  G  PLH AA +G  +  ++L  V+   LD  D+DG T+  L+
Sbjct: 264 GEISADLWGGTPLHDAAENGELECCQIL-VVNGAELDVRDRDGYTAADLS 312



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 67/258 (25%), Positives = 109/258 (42%), Gaps = 11/258 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAG-DLNAKDN 78
           AA +G +     L        A R   G T AH ASA  +   L ++ +  G  +  KDN
Sbjct: 43  AARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDN 102

Query: 79  AGNTPLHVAVENEALDAIEYLLQQ-HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
           +G T LH+A      + + +LL     + +   +    PIH A        L++  ++  
Sbjct: 103 SGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYP 162

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
              VN   ++G T L+ A    H    + L+ +  A+     ++G  P+H AA+   S  
Sbjct: 163 -EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPV 221

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
           I V+L       CT +  +S  D +G   +H A   G  K +   L  G +IS       
Sbjct: 222 I-VWLV-----SCT-DVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWG-G 273

Query: 258 TPVHLACAQGALDIVKLM 275
           TP+H A   G L+  +++
Sbjct: 274 TPLHDAAENGELECCQIL 291



 Score = 69.3 bits (162), Expect = 7e-11
 Identities = 79/317 (24%), Positives = 134/317 (42%), Gaps = 25/317 (7%)

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGA-KISTQQHDLSTPVHLACAQGALDIVKLM 275
           SL D    +P+H A   G +  +   +   A   + +  + +TP H A A G L  ++ +
Sbjct: 30  SLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWL 89

Query: 276 FTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLL 333
            +     +  C +   D    T +H AA F HPE+VN+L++  G D          P+  
Sbjct: 90  LS-----QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHY 144

Query: 334 AASRAGWRTVHTLIR---LGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           AA++  + ++  L+     G + Q K  N    L+L     G LE         C     
Sbjct: 145 AAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQE-GHLE-VTQYLVQECGAD-- 198

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTA 449
              + + + G +PLH A++ GH   +  L+      ++ ++ +  + +HFAA  G     
Sbjct: 199 --PHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVL 256

Query: 450 CQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
             LL    G      +D  G TPLH A+  G      +L+  GA L  RD +G     L+
Sbjct: 257 SWLL-LHGGEI---SADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLS 312

Query: 509 AMSGYTKTIELLHSVHS 525
             +G++     L +V +
Sbjct: 313 DFNGHSHCTRYLRTVEN 329



 Score = 66.5 bits (155), Expect = 5e-10
 Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 5/153 (3%)

Query: 396 KDNTGCSPLHYASREGHIRSLENLIRLGAC-INLKNNNNESPLHFAARYGRFHTACQLLD 454
           +D     P+H+A+R G +  L  L+   A     +  N  +P H A+  G  H AC    
Sbjct: 32  RDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATG--HLACLQWL 89

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA--LLHRDHNGRNPLHLAAMSG 512
             +G   + + D  G T LH+A+R GH  VV+ LL+ G          G  P+H AA  G
Sbjct: 90  LSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKG 149

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATME 545
              ++ LL   +   ++   K+G T L+LA  E
Sbjct: 150 DFPSLRLLVEHYPEGVNAQTKNGATPLYLACQE 182



 Score = 54.4 bits (125), Expect = 2e-06
 Identities = 65/312 (20%), Positives = 117/312 (37%), Gaps = 17/312 (5%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHF-INNYAGDLNAK 76
           +QAA  G +D    L+ +     ++RD       H A+     + L F +   A    A+
Sbjct: 7   LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQ-HVETSVLNEKCQAPIHMATELNKVSVLQVFAKY 135
              G TP H A     L  +++LL Q        +      +H+A       V+  +  +
Sbjct: 67  ARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVN-WLLH 125

Query: 136 KSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASS 195
               +     + G   +H+AA        ++L+            NG  P++ A +    
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185

Query: 196 RTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKA-VELCLRSGAKISTQQH 254
              +  +Q      C  +     +D  G  PLH+A   G     V L   +   +S Q  
Sbjct: 186 EVTQYLVQ-----ECGADPHARAHD--GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDK 238

Query: 255 DLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLI 314
           D +T +H A ++G   ++  +        H    S D+   TP+H AA     E    L+
Sbjct: 239 DGATAMHFAASRGHTKVLSWLLL------HGGEISADLWGGTPLHDAAENGELECCQILV 292

Query: 315 NEGSDINPLDKE 326
             G++++  D++
Sbjct: 293 VNGAELDVRDRD 304



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 2/89 (2%)

Query: 472 PLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           P+H A+R G    +  L+   AL    R  NG  P H A+ +G+   ++ L S     + 
Sbjct: 39  PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
             D  G T LHLA     P  +  LL  G
Sbjct: 99  DKDNSGATVLHLAARFGHPEVVNWLLHHG 127


>BX640903-1|CAE45949.1|  714|Homo sapiens hypothetical protein
           protein.
          Length = 714

 Score = 83.4 bits (197), Expect = 4e-15
 Identities = 75/322 (23%), Positives = 142/322 (44%), Gaps = 16/322 (4%)

Query: 4   IHLSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNIL 63
           ++L+  T+  LS        G     +R  + +  R +     G TA H A  ++N  ++
Sbjct: 176 VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI 235

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATEL 123
             + +   D+      G T LH+A     L+A + LLQ     ++ +     P+H+A   
Sbjct: 236 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 295

Query: 124 NKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD-LDAEWKKPCNNG 182
               V ++  K+ +  +VN  GE G   LH A+       AK+L+ +   A+     N  
Sbjct: 296 GHEQVTRLLLKFGA--DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 353

Query: 183 YYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIK-AVEL 241
           + P+H  ++      ++  LQ   +    +  ++++Y   G+ PLH A + G  + A E+
Sbjct: 354 HVPLHFCSRFGHHDMVKYLLQSDLE---VQPHVVNIY---GDTPLHLACYNGKFEVAKEI 407

Query: 242 CLRSGAKISTQQHDLS-TPVHLACAQG-ALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
              SG +  T+++  S T  H AC  G ++D+VK +      +    +        T +H
Sbjct: 408 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL----DQNVININHQGRDGHTGLH 463

Query: 300 CAAMFDHPEIVNYLINEGSDIN 321
            A    H  +V +L++ G+D++
Sbjct: 464 SACYHGHIRLVQFLLDNGADMS 485



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 84/365 (23%), Positives = 151/365 (41%), Gaps = 23/365 (6%)

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKN----ASSRTIEVFLQWGEQRGCTREQMISLYDN 221
           IL+   D EWKK  +  Y    E  ++          E+   +G     ++  +    +N
Sbjct: 126 ILLIHSD-EWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTEN 184

Query: 222 EGNVPLH-SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
            G   LH   + GG    +   +  G + S    +  T +HLA  +   +++  +     
Sbjct: 185 -GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL---- 239

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGW 340
               A +       +T +H A +  H E  + L+  G+++N  D    +PL +AA     
Sbjct: 240 -HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 298

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
           +    L++ GAD+ +        LHL    G     F    K   E+     +N +DN  
Sbjct: 299 QVTRLLLKFGADVNVSGEVGDRPLHLASAKG-----FLNIAKLLMEEGSKADVNAQDNED 353

Query: 401 CSPLHYASREGHIRSLENLIR--LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
             PLH+ SR GH   ++ L++  L    ++ N   ++PLH A   G+F  A +++    G
Sbjct: 354 HVPLHFCSRFGHHDMVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SG 412

Query: 459 TFIINESDGEGLTPLHIASREGHT-RVVHLLLNRGA--LLHRDHNGRNPLHLAAMSGYTK 515
           T  + + +    T  H A   G +  +V  LL++    + H+  +G   LH A   G+ +
Sbjct: 413 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 472

Query: 516 TIELL 520
            ++ L
Sbjct: 473 LVQFL 477



 Score = 70.5 bits (165), Expect = 3e-11
 Identities = 72/287 (25%), Positives = 120/287 (41%), Gaps = 28/287 (9%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           T +H A   D+ E++  L++ G+DI  +     + L +A           L++ GA++ +
Sbjct: 221 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 280

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGH 412
           +D      LH+    G           +   + LL+    +N     G  PLH AS +G 
Sbjct: 281 QDAVFFTPLHIAAYYG----------HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGF 330

Query: 413 IRSLENLIRLG--ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT--FIINESDGE 468
           +   + L+  G  A +N ++N +  PLHF +R+G       LL SD      ++N     
Sbjct: 331 LNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDMVKYLLQSDLEVQPHVVNIY--- 387

Query: 469 GLTPLHIASREGHTRVVHLLLNRG---ALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
           G TPLH+A   G   V   ++      +L   +       H A    Y K+I+L+  +  
Sbjct: 388 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT--YGKSIDLVKFLLD 445

Query: 526 HLLDQID---KDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMS 569
             +  I+   +DG+T LH A        +  LL  G  +S    D S
Sbjct: 446 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMSLVACDPS 492



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 462 INESDGEGLTPLHIA----SREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTI 517
           +N     GL+ LH+      ++ H R + L   R + L R  NG   LHLA      + I
Sbjct: 178 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAELI 235

Query: 518 -ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN-MDMSAIDYAI 575
             LLHS     + Q+   G T+LH+AT+     +  +LL  G  ++  + +  + +  A 
Sbjct: 236 TSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 293

Query: 576 YY 577
           YY
Sbjct: 294 YY 295


>X69838-1|CAA49491.1| 1001|Homo sapiens G9a protein.
          Length = 1001

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 499

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 500 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 558

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 559 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 612

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 613 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 666



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 502 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 561

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 562 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 619

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 620 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 479 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 533

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 534 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 593

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 594 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 645

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 646 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 677



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 458 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 517

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 518 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 575

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 627

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 628 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 663



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 536

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 537 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 595

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 596 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 646

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 647 HIAARESYHDCVLLFLSRGA 666



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 453 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 507

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 508 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 559

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 560 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 614

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 615 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 672



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 581 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 639

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 640 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674


>BX005460-6|CAM26152.1|  922|Homo sapiens euchromatic histone-lysine
           N-methyltransferase 2 protein.
          Length = 922

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 366 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 420

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 421 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 479

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 480 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 533

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 534 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 587



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 423 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 482

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 483 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 540

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 541 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 595



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 400 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 454

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 455 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 514

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 515 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 566

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 567 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 598



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 379 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 438

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 439 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 496

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 497 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 548

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 549 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 584



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 398 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 457

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 458 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 516

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 517 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 567

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 568 HIAARESYHDCVLLFLSRGA 587



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 374 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 428

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 429 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 480

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 481 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 535

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 536 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 593



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 502 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 560

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 561 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 595


>BX005460-5|CAM26151.1|  888|Homo sapiens euchromatic histone-lysine
           N-methyltransferase 2 protein.
          Length = 888

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 332 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 386

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 387 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 445

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 446 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 499

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 500 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 553



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 389 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 448

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 449 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 506

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 507 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 561



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 366 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 420

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 421 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 480

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 481 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 532

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 533 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 564



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 345 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 404

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 405 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 462

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 463 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 514

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 515 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 550



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 364 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 423

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 424 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 482

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 483 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 533

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 534 HIAARESYHDCVLLFLSRGA 553



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 340 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 394

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 395 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 446

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 447 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 501

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 502 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 559



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 468 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 526

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 527 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 561


>BC020970-1|AAH20970.2| 1198|Homo sapiens EHMT2 protein protein.
          Length = 1198

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 642 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 696

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 697 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 755

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 756 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 809

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 810 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 863



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 699 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 758

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 759 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 816

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 817 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 871



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 676 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 730

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 731 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 790

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 791 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 842

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 843 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 874



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 655 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 714

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 715 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 772

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 773 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 824

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 825 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 860



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 674 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 733

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 734 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 792

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 793 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 843

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 844 HIAARESYHDCVLLFLSRGA 863



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 650 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 704

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 705 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 756

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 757 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 811

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 812 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 869



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 778 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 836

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 837 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 871


>BC018718-1|AAH18718.1| 1001|Homo sapiens EHMT2 protein protein.
          Length = 1001

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 499

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 500 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 558

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 559 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 612

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 613 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 666



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 502 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 561

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 562 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 619

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 620 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 479 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 533

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 534 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 593

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 594 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 645

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 646 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 677



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 458 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 517

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 518 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 575

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 627

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 628 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 663



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 536

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 537 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 595

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 596 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 646

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 647 HIAARESYHDCVLLFLSRGA 666



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 453 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 507

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 508 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 559

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 560 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 614

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 615 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 672



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 581 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 639

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 640 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674


>BC009351-1|AAH09351.1| 1209|Homo sapiens EHMT2 protein protein.
          Length = 1209

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 653 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 707

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 708 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 766

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 767 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 820

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 821 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 874



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 710 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 769

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 770 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 827

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 828 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 882



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 687 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 741

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 742 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 801

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 802 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 853

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 854 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 885



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 666 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 725

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 726 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 783

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 784 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 835

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 836 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 871



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 685 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 744

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 745 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 803

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 804 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 854

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 855 HIAARESYHDCVLLFLSRGA 874



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 661 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 715

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 716 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 767

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 768 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 822

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 823 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 880



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 789 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 847

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 848 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 882


>BC002686-1|AAH02686.2| 1043|Homo sapiens EHMT2 protein protein.
          Length = 1043

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 487 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 541

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 542 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 600

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 601 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 654

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 655 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 708



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 544 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 603

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 604 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 661

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 662 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 716



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 521 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 575

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 576 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 635

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 636 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 687

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 688 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 719



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 500 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 559

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 560 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 617

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 618 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 669

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 670 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 705



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 519 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 578

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 579 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 637

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 638 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 688

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 689 HIAARESYHDCVLLFLSRGA 708



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 495 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 549

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 550 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 601

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 602 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 656

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 657 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 714



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 623 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 681

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 682 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 716


>BA000025-4|BAB63295.1| 1001|Homo sapiens G9A protein.
          Length = 1001

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 499

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 500 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 558

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 559 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 612

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 613 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 666



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 502 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 561

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 562 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 619

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 620 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 479 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 533

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 534 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 593

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 594 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 645

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 646 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 677



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 458 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 517

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 518 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 575

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 627

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 628 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 663



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 536

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 537 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 595

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 596 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 646

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 647 HIAARESYHDCVLLFLSRGA 666



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 453 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 507

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 508 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 559

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 560 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 614

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 615 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 672



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 581 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 639

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 640 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674


>AL844853-4|CAI41853.1| 1210|Homo sapiens HLA-B associated
           transcript 8 protein.
          Length = 1210

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 767

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 768 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 821

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 822 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 875



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 771 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 828

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 829 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 742

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 854

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 855 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 886



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 727 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 836

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 804

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 805 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 855

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 856 HIAARESYHDCVLLFLSRGA 875



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 662 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 716

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 717 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 768

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 769 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 823

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 824 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 790 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 848

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 849 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883


>AL844853-3|CAI41852.1| 1176|Homo sapiens HLA-B associated
           transcript 8 protein.
          Length = 1176

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 674

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 675 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 733

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 734 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 787

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 788 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 841



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 737 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 794

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 795 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 708

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 820

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 821 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 852



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 693 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 802

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 803 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 838



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 770

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 771 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 821

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 822 HIAARESYHDCVLLFLSRGA 841



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 628 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 682

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 683 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 734

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 735 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 789

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 790 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 847



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 756 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 814

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 815 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849


>AL671762-16|CAI18224.2| 1210|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1210

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 767

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 768 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 821

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 822 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 875



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 771 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 828

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 829 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 742

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 854

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 855 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 886



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 727 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 836

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 804

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 805 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 855

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 856 HIAARESYHDCVLLFLSRGA 875



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 662 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 716

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 717 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 768

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 769 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 823

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 824 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 790 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 848

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 849 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883


>AL671762-15|CAI18226.2| 1176|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1176

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 674

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 675 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 733

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 734 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 787

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 788 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 841



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 737 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 794

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 795 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 708

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 820

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 821 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 852



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 693 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 802

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 803 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 838



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 770

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 771 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 821

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 822 HIAARESYHDCVLLFLSRGA 841



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 628 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 682

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 683 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 734

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 735 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 789

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 790 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 847



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 756 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 814

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 815 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849


>AL671762-14|CAM25534.1| 1267|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1267

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 765

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 766 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 824

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 825 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 878

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 879 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 932



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 768 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 827

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 828 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 885

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 886 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 940



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 745 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 799

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 800 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 859

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 860 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 911

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 912 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 943



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 724 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 783

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 784 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 841

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 842 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 893

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 894 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 929



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 743 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 802

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 803 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 861

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 862 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 912

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 913 HIAARESYHDCVLLFLSRGA 932



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 719 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 773

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 774 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 825

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 826 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 880

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 881 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 938



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 847 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 905

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 906 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 940


>AL671762-13|CAM25533.1| 1233|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1233

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 731

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 732 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 790

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 791 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 844

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 845 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 898



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 734 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 793

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 794 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 851

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 852 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 906



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 711 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 765

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 766 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 825

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 826 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 877

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 878 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 909



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 690 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 749

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 750 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 807

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 808 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 859

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 860 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 895



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 709 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 768

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 769 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 827

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 828 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 878

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 879 HIAARESYHDCVLLFLSRGA 898



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 685 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 739

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 740 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 791

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 792 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 846

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 847 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 904



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 813 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 871

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 872 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 906


>AL662834-27|CAI17747.2| 1176|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1176

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 674

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 675 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 733

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 734 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 787

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 788 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 841



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 737 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 794

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 795 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 654 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 708

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 769 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 820

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 821 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 852



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 693 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 750

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 802

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 803 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 838



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 770

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 771 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 821

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 822 HIAARESYHDCVLLFLSRGA 841



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 628 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 682

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 683 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 734

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 735 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 789

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 790 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 847



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 756 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 814

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 815 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 849


>AL662834-26|CAI17748.1| 1210|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1210

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 767

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 768 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 821

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 822 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 875



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 771 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 828

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 829 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 742

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 854

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 855 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 886



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 727 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 836

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 804

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 805 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 855

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 856 HIAARESYHDCVLLFLSRGA 875



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 662 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 716

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 717 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 768

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 769 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 823

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 824 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 790 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 848

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 849 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883


>AL662834-25|CAM24993.1| 1267|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1267

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 765

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 766 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 824

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 825 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 878

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 879 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 932



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 768 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 827

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 828 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 885

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 886 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 940



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 745 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 799

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 800 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 859

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 860 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 911

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 912 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 943



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 724 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 783

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 784 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 841

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 842 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 893

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 894 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 929



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 743 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 802

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 803 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 861

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 862 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 912

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 913 HIAARESYHDCVLLFLSRGA 932



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 719 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 773

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 774 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 825

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 826 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 880

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 881 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 938



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 847 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 905

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 906 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 940


>AL662834-24|CAM24992.1| 1233|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 1233

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 731

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 732 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 790

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 791 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 844

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 845 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 898



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 734 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 793

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 794 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 851

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 852 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 906



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 711 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 765

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 766 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 825

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 826 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 877

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 878 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 909



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 690 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 749

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 750 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 807

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 808 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 859

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 860 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 895



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 709 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 768

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 769 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 827

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 828 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 878

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 879 HIAARESYHDCVLLFLSRGA 898



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 685 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 739

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 740 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 791

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 792 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 846

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 847 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 904



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 813 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 871

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 872 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 906


>AJ315532-1|CAC86666.1| 1210|Homo sapiens NG36/G9a protein.
          Length = 1210

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 708

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 709 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 767

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 768 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 821

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 822 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 875



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 771 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 828

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 829 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 688 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 742

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 803 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 854

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 855 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 886



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 727 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 784

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 836

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 837 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 872



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 804

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 805 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 855

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 856 HIAARESYHDCVLLFLSRGA 875



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 662 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 716

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 717 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 768

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 769 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 823

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 824 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 881



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 790 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 848

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 849 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 883


>AF134726-3|AAD21812.1| 1001|Homo sapiens G9A protein.
          Length = 1001

 Score = 83.0 bits (196), Expect = 6e-15
 Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 18/237 (7%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 499

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 500 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 558

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N     
Sbjct: 559 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENIC 612

Query: 437 LHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
           LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L+RGA
Sbjct: 613 LHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFLSRGA 666



 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 50/176 (28%), Positives = 78/176 (44%), Gaps = 4/176 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 502 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 561

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRN-PLHLAAMS 511
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N  N  LH A+ +
Sbjct: 562 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFT 619

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
           G     E+L +     L  ++  G+T LH+A  E+    + L LS G      N +
Sbjct: 620 GSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 15/212 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 479 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 533

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 534 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 593

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
            L+  GAD+ L D      LH     G   + +   + +  C+      L+  +  G +P
Sbjct: 594 MLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD------LHAVNYHGDTP 645

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNES 435
           LH A+RE +   +   +  GA   L+N   ++
Sbjct: 646 LHIAARESYHDCVLLFLSRGANPELRNKEGDT 677



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 10/216 (4%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 458 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 517

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 518 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 575

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L        TR   ++L DNE N+ LH A   G     E+
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEV 627

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 628 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 663



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 81/200 (40%), Gaps = 10/200 (5%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 536

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 537 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 595

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           +T   A+     N     +H A+   S+   EV L       C     +   +  G+ PL
Sbjct: 596 LT-RGADVTLTDNEENICLHWASFTGSAAIAEVLL----NARCD----LHAVNYHGDTPL 646

Query: 228 HSAVHGGDIKAVELCLRSGA 247
           H A        V L L  GA
Sbjct: 647 HIAARESYHDCVLLFLSRGA 666



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 55/238 (23%), Positives = 101/238 (42%), Gaps = 20/238 (8%)

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCN 180
           EL KV +L +       F  +Q  +  RT LH AA     ++C  +L     A       
Sbjct: 453 ELQKV-ILMLLDNLDPNFQSDQQSK--RTPLHAAAQKGSVEICHVLL--QAGANINAVDK 507

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
               P+ EA  N         +Q G   GC   +     + +G+  LH A   G+++ V 
Sbjct: 508 QQRTPLMEAVVNNHLEVARYMVQRG---GCVYSK-----EEDGSTCLHHAAKIGNLEMVS 559

Query: 241 LCLRSG-AKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
           L L +G   ++ Q     TP+  A     +++++++ T     + A +T  D ++   +H
Sbjct: 560 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT-----RGADVTLTDNEENICLH 614

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
            A+      I   L+N   D++ ++    +PL +AA  +    V   +  GA+ +L++
Sbjct: 615 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRN 672



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 581 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 639

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 640 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 674


>BC011608-1|AAH11608.2|  716|Homo sapiens EHMT1 protein protein.
          Length = 716

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 194 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 248

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 249 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 308

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 309 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 359

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 360 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 409



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 226 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 283

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 284 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 343

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 344 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 389



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 214

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 215 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 274

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 275 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 323

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 324 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 383

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 384 TLKNK---EGETPLQCAS 398



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 193 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 249

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 250 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 309

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 310 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 355



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 193 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 250

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 251 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 310

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 311 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 362

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 363 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 399



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 305 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 364

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 365 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 409



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 264 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 323

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 324 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 381

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 382 DVTLKNKEGETPLQCASLN 400



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 192 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 251

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 252 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 310

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 311 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 361

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 362 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 397



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 218

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 219 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 247


>AY083210-1|AAM09024.1| 1267|Homo sapiens euchromatic histone
           methyltransferase 1 protein.
          Length = 1267

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 745 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 799

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 800 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 859

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 860 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 910

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 911 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 777 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 834

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 835 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 894

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 895 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 940



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 765

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 766 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 825

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 826 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 934

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 935 TLKNK---EGETPLQCAS 949



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 800

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 861 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 906



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 801

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 862 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 913

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 914 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 950



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 856 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 915

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 815 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 932

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 933 DVTLKNKEGETPLQCASLN 951



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 803 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 862 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 912

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 913 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 948



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798


>AL611925-3|CAH71077.1| 1267|Homo sapiens euchromatic histone-lysine
           N-methyltransferase 1 protein.
          Length = 1267

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 745 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 799

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 800 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 859

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 860 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 910

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 911 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 777 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 834

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 835 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 894

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 895 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 940



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 765

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 766 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 825

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 826 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 934

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 935 TLKNK---EGETPLQCAS 949



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 800

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 861 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 906



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 801

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 862 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 913

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 914 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 950



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 856 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 915

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 815 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 932

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 933 DVTLKNKEGETPLQCASLN 951



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 803 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 862 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 912

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 913 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 948



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798


>AL590627-3|CAI17355.1| 1267|Homo sapiens euchromatic histone-lysine
           N-methyltransferase 1 protein.
          Length = 1267

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 745 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 799

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 800 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 859

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 860 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 910

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 911 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 777 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 834

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 835 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 894

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 895 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 940



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 765

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 766 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 825

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 826 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 934

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 935 TLKNK---EGETPLQCAS 949



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 800

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 861 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 906



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 801

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 862 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 913

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 914 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 950



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 856 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 915

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 960



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 815 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 874

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 875 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 932

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 933 DVTLKNKEGETPLQCASLN 951



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 803 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 862 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 912

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 913 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 948



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798


>AB058779-1|BAB47505.2|  803|Homo sapiens KIAA1876 protein protein.
          Length = 803

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 395 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 449

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 450 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 509

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 510 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 560

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 561 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 610



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 427 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 484

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 485 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 544

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 545 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 590



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 415

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 416 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 475

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 476 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 524

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 525 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 584

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 585 TLKNK---EGETPLQCAS 599



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 450

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 510

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 511 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 556



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 451

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 452 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 512 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 563

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 564 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 600



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 506 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 565

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 566 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 610



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 465 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 524

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 525 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 582

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 583 DVTLKNKEGETPLQCASLN 601



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 452

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 453 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 512 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 562

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 563 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 598



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 419

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 448


>AB028932-1|BAB56104.1|  917|Homo sapiens GLP1 protein.
          Length = 917

 Score = 81.0 bits (191), Expect = 2e-14
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 17/230 (7%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G +    + +++GA I T   D  TP+  A     L+ VK +      +  A
Sbjct: 395 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-----KAGA 449

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
            +   D +  T +H AA   H E+V YL++ G  D+N  D    +P++ A        V 
Sbjct: 450 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 509

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL--LNEKDNTGCS 402
            L+  G+DI ++D      LH    +G         C D  E  L     L+  +  G S
Sbjct: 510 LLLSKGSDINIRDNEENICLHWAAFSG---------CVDIAEILLAAKCDLHAVNIHGDS 560

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           PLH A+RE     +   +   + + LKN   E+PL  A+   +  +A Q+
Sbjct: 561 PLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 610



 Score = 78.2 bits (184), Expect = 2e-13
 Identities = 50/167 (29%), Positives = 86/167 (51%), Gaps = 4/167 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PL  A+   H+ +++ LI+ GA ++ K+    + LH AA+ G +     LL +  G   
Sbjct: 427 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN--GQMD 484

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
           +N  D  G TP+  A+   H  +V LLL++G+ ++ RD+     LH AA SG     E+L
Sbjct: 485 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 544

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMD 567
            +    L   ++  G++ LH+A  EN+   + L LS    ++  N +
Sbjct: 545 LAAKCDL-HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 590



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 71/258 (27%), Positives = 115/258 (44%), Gaps = 26/258 (10%)

Query: 227 LHSAVHGGDIKAVELCLRSGA--KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           L+ +   G+++ V L L  G       +  +  +P+H A   G +DI  ++      +  
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-----QAG 415

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A + +C   + TP+  AA  +H E V YLI  G+ ++P D E  + L LAA +  +  V 
Sbjct: 416 ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ 475

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL-----LNEKDNT 399
            L+  G      D+N ++       +GG      A+   H +   L L     +N +DN 
Sbjct: 476 YLLSNGQ----MDVNCQD-------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 524

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
               LH+A+  G +   E L+     ++  N + +SPLH AAR  R+      L  D   
Sbjct: 525 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 584

Query: 460 FIINESDGEGLTPLHIAS 477
            + N+   EG TPL  AS
Sbjct: 585 TLKNK---EGETPLQCAS 599



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           SPLH A+  GH+     L++ GA I+  + +  +PL  AA          L+   K   +
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI---KAGAL 450

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSGYTKTIEL 519
           ++  D EG T LH+A+++GH  VV  LL+ G +    +D  G  P+  A    +   ++L
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 510

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
           L S  S  ++  D + N  LH A          +LL+  C L   N+
Sbjct: 511 LLSKGSD-INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 556



 Score = 60.5 bits (140), Expect = 3e-08
 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 15/222 (6%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           +PLH A E   +D    L+Q        +E  + P+  A E N +  ++   K  +L  V
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL--V 451

Query: 142 NQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
           +     G T LH AA   H    + L+++   +     + G+ P+  A +      +++ 
Sbjct: 452 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G          I++ DNE N+ LH A   G +   E+ L +   +        +P+H
Sbjct: 512 LSKGSD--------INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 563

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAM 303
           +A  +   D V L  +     + + +T  + +  TP+ CA++
Sbjct: 564 IAARENRYDCVVLFLS-----RDSDVTLKNKEGETPLQCASL 600



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 1/105 (0%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D ++L LS+ S + +RD       H A+     +I   +     DL+A +  G++PLH+A
Sbjct: 506 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 565

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                 D +   L +  + ++ N++ + P+  A+  ++V S LQ+
Sbjct: 566 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 610



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 2/139 (1%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA+ G+ +    L  +    +  +D  G T    A+   + +++  + +   D+N +DN 
Sbjct: 465 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 524

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
            N  LH A  +  +D  E LL    +   +N    +P+H+A   N+   + +F    S  
Sbjct: 525 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-- 582

Query: 140 NVNQGGEHGRTALHFAAIH 158
           +V    + G T L  A+++
Sbjct: 583 DVTLKNKEGETPLQCASLN 601



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 45/216 (20%), Positives = 87/216 (40%), Gaps = 10/216 (4%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   + +I H +     +++       TPL  A EN  L+A++YL++      
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 452

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
             + +    +H+A +     V+Q +       +VN   + G T + +A  + H    K+L
Sbjct: 453 PKDAEGSTCLHLAAKKGHYEVVQ-YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           ++   ++     N     +H AA +      E+ L       C     +   +  G+ PL
Sbjct: 512 LSK-GSDINIRDNEENICLHWAAFSGCVDIAEILL----AAKCD----LHAVNIHGDSPL 562

Query: 228 HSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLA 263
           H A        V L L   + ++ +  +  TP+  A
Sbjct: 563 HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 598



 Score = 33.9 bits (74), Expect = 3.4
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 473 LHIASREGHTRVVHLLLNRGA--LLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           L+ ++R+G  + V L+L  G       +H N R+PLH AA +G+     +L    ++ +D
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 419

Query: 530 QIDKDGNTSLHLATMENKPSSIALLLSMG 558
              +D  T L  A   N   ++  L+  G
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 448


>DQ508815-1|ABF60230.1|  593|Homo sapiens SARP protein.
          Length = 593

 Score = 80.6 bits (190), Expect = 3e-14
 Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 14/285 (4%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG TA+H A+ R     +  +     +L A+D+ G TPLH+A  +     ++ +L+  V+
Sbjct: 183 RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVD 242

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            SV +++   P+H A    ++  LQ+  K+    ++     +G   +H AA+  H  C K
Sbjct: 243 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGC--SIEDVDYNGNLPVHLAAMEGHLHCFK 300

Query: 166 ILITDLDAEWK--KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
            L++ + +  +  K  N+    + + A+    + I  F+Q  E  G   E   +L     
Sbjct: 301 FLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL----- 355

Query: 224 NVPLHSAVHGGDIKAVELCLRSGA-KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
             P H A   GD+  ++  +  G   I+ +  + STP+H A  QG ++ ++ +  M    
Sbjct: 356 AFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADS 415

Query: 283 ---KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                A     DV K    H AA+    E+  Y I++ ++I+  D
Sbjct: 416 NITNKAGERPSDVAKRF-AHLAAVKLLEELQKYDIDDENEIDEND 459



 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 83/317 (26%), Positives = 131/317 (41%), Gaps = 33/317 (10%)

Query: 147 HGRTALHFAAIHDHDL-CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           H  T LH+AA H   L C   L+    A+       G+   H AA       ++  +  G
Sbjct: 150 HKFTPLHWAA-HSGSLECLHWLLWH-GADITHVTTRGWTASHIAAIRGQDACVQALIMNG 207

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     ++  D+ G  PLH A   G    +++ LRSG   S        PVH A  
Sbjct: 208 AN--------LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAF 259

Query: 266 QGALDIVKLMFTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
            G L  ++L+       K  C +   D     P+H AAM  H     +L++  S    + 
Sbjct: 260 HGRLGCLQLLV------KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 313

Query: 325 K---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL----HLVVMNGGRLEDF 377
           K   +    +L  A R   + +   I+ GA+ + KD+  +  L    H+    G      
Sbjct: 314 KAFNDNGENVLDLAQRFFKQNILQFIQ-GAEYEGKDLEDQETLAFPGHVAAFKGD----- 367

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
               K   E  ++ + NE+ + G +P+H A+ +GHI  L+ LI++GA  N+ N   E P 
Sbjct: 368 LGMLKKLVEDGVINI-NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPS 426

Query: 438 HFAARYGRFHTACQLLD 454
             A R+     A +LL+
Sbjct: 427 DVAKRFAHL-AAVKLLE 442



 Score = 65.7 bits (153), Expect = 9e-10
 Identities = 67/286 (23%), Positives = 113/286 (39%), Gaps = 12/286 (4%)

Query: 285 ACLTSCDV-QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTV 343
           A +   DV  K TP+H AA     E +++L+  G+DI  +     +   +AA R     V
Sbjct: 141 ASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACV 200

Query: 344 HTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
             LI  GA++  +D      LHL   +G          +   + S+       D     P
Sbjct: 201 QALIMNGANLTAQDDRGCTPLHLAATHGHSF-TLQIMLRSGVDPSV------TDKREWRP 253

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD-SDKGTFII 462
           +HYA+  G +  L+ L++ G  I   + N   P+H AA  G  H    L+      T ++
Sbjct: 254 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 313

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLN---RGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
              +  G   L +A R     ++  +      G  L        P H+AA  G    ++ 
Sbjct: 314 KAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKK 373

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           L       +++   +G+T +H A  +     +  L+ MG   +  N
Sbjct: 374 LVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 419



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 71/356 (19%), Positives = 138/356 (38%), Gaps = 21/356 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           KV+      A  +G+V     + +   S   +      T  H A+   +   LH++  + 
Sbjct: 115 KVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHG 174

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+      G T  H+A        ++ L+      +  +++   P+H+A        LQ
Sbjct: 175 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQ 234

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           +    +S  + +   +     +H+AA H    C ++L+       +    NG  P+H AA
Sbjct: 235 IM--LRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV-KWGCSIEDVDYNGNLPVHLAA 291

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSA---VHGGDIKAVELCLRSGA 247
                   +  +     R  +  Q++  +++ G   L  A        ++ ++     G 
Sbjct: 292 MEGHLHCFKFLV----SRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGK 347

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHP 307
            +  Q+  L+ P H+A  +G L ++K +     ++    +        TP+H AA   H 
Sbjct: 348 DLEDQE-TLAFPGHVAAFKGDLGMLKKLV----EDGVININERADNGSTPMHKAAGQGHI 402

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH-TLIRLGADIQLKDINSRN 362
           E + +LI  G+D N  +K    P     S    R  H   ++L  ++Q  DI+  N
Sbjct: 403 ECLQWLIKMGADSNITNKAGERP-----SDVAKRFAHLAAVKLLEELQKYDIDDEN 453


>AK095193-1|BAC04496.1|  389|Homo sapiens protein ( Homo sapiens
           cDNA FLJ37874 fis, clone BRSSN2018731, weakly similar to
           ANKYRIN 1. ).
          Length = 389

 Score = 80.2 bits (189), Expect = 4e-14
 Identities = 71/285 (24%), Positives = 129/285 (45%), Gaps = 14/285 (4%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG TA+H A+ R     +  +     +L A+D+ G TPLH+A  +     ++ +L+  V+
Sbjct: 64  RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVD 123

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            SV +++   P+H A    ++  LQ+  K+     +     +G   +H AA+  H  C K
Sbjct: 124 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGC--GIEDVDYNGNLPVHLAAMEGHLHCFK 181

Query: 166 ILITDLDAEWK--KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
            L++ + +  +  K  N+    + + A+    + I  F+Q  E  G   E   +L     
Sbjct: 182 FLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL----- 236

Query: 224 NVPLHSAVHGGDIKAVELCLRSGA-KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
             P H A   GD+  ++  +  G   I+ +  + STP+H A  QG ++ ++ +  M    
Sbjct: 237 AFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADS 296

Query: 283 ---KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                A     DV K    H AA+    E+  Y I++ ++I+  D
Sbjct: 297 NITNKAGERPSDVAKRF-AHLAAVKLLEELQKYDIDDENEIDEND 340



 Score = 76.2 bits (179), Expect = 7e-13
 Identities = 67/247 (27%), Positives = 108/247 (43%), Gaps = 22/247 (8%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           ++  D+ G  PLH A   G    +++ LRSG   S        PVH A   G L  ++L+
Sbjct: 91  LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 150

Query: 276 FTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDK---ERRSPL 331
                  K  C +   D     P+H AAM  H     +L++  S    + K   +    +
Sbjct: 151 V------KWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENV 204

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVL----HLVVMNGGRLEDFAASCKDHCEK 387
           L  A R   + +   I+ GA+ + KD+  +  L    H+    G          K   E 
Sbjct: 205 LDLAQRFFKQNILQFIQ-GAEYEGKDLEDQETLAFPGHVAAFKGD-----LGMLKKLVED 258

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
            ++ + NE+ + G +P+H A+ +GHI  L+ LI++GA  N+ N   E P   A R+    
Sbjct: 259 GVINI-NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHL- 316

Query: 448 TACQLLD 454
            A +LL+
Sbjct: 317 AAVKLLE 323



 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 79/312 (25%), Positives = 126/312 (40%), Gaps = 19/312 (6%)

Query: 227 LHSAVHGGDIKAVE--LCLR----SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
           +H AV  GD+K +   +CL      GA I+       T  H+A  +G    V+ +     
Sbjct: 30  IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM--- 86

Query: 281 KEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGW 340
               A LT+ D +  TP+H AA   H   +  ++  G D +  DK    P+  AA     
Sbjct: 87  --NGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL 144

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             +  L++ G  I+  D N    +HL  M  G L  F          S  Q+L   ++ G
Sbjct: 145 GCLQLLVKWGCGIEDVDYNGNLPVHLAAME-GHLHCFKFLVSR--MSSATQVLKAFNDNG 201

Query: 401 CSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS--DKG 458
            + L  A R      L+ +   GA    K+  ++  L F      F     +L    + G
Sbjct: 202 ENVLDLAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG 259

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTI 517
              INE    G TP+H A+ +GH   +  L+  GA  +  +  G  P  +A    +   +
Sbjct: 260 VININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAV 319

Query: 518 ELLHSVHSHLLD 529
           +LL  +  + +D
Sbjct: 320 KLLEELQKYDID 331



 Score = 52.4 bits (120), Expect = 9e-06
 Identities = 46/160 (28%), Positives = 69/160 (43%), Gaps = 11/160 (6%)

Query: 404 LHYASREGHIRSLENLIRL------GACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           +H A R G ++ L  ++ L      GA I        +  H AA  G+   AC       
Sbjct: 30  IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQ--DACVQALIMN 87

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKT 516
           G  +  + D  G TPLH+A+  GH+  + ++L  G      D     P+H AA  G    
Sbjct: 88  GANLTAQDD-RGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146

Query: 517 IELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
           ++LL      + D +D +GN  +HLA ME        L+S
Sbjct: 147 LQLLVKWGCGIED-VDYNGNLPVHLAAMEGHLHCFKFLVS 185



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 68/331 (20%), Positives = 129/331 (38%), Gaps = 23/331 (6%)

Query: 38  SRLAVRDGRGRTAAHQASARNNTNI--LHFINNYAGDLNAKDNAGNTPLHVAVENEALDA 95
           SR  V  G    A      +  + I  LH++  +  D+      G T  H+A        
Sbjct: 21  SRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDAC 80

Query: 96  IEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFA 155
           ++ L+      +  +++   P+H+A        LQ+    +S  + +   +     +H+A
Sbjct: 81  VQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM--LRSGVDPSVTDKREWRPVHYA 138

Query: 156 AIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQM 215
           A H    C ++L+       +    NG  P+H AA        +  +     R  +  Q+
Sbjct: 139 AFHGRLGCLQLLV-KWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLV----SRMSSATQV 193

Query: 216 ISLYDNEGNVPLHSA---VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV 272
           +  +++ G   L  A        ++ ++     G  +  Q+  L+ P H+A  +G L ++
Sbjct: 194 LKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQE-TLAFPGHVAAFKGDLGML 252

Query: 273 KLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLL 332
           K +     ++    +        TP+H AA   H E + +LI  G+D N  +K    P  
Sbjct: 253 KKLV----EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERP-- 306

Query: 333 LAASRAGWRTVH-TLIRLGADIQLKDINSRN 362
              S    R  H   ++L  ++Q  DI+  N
Sbjct: 307 ---SDVAKRFAHLAAVKLLEELQKYDIDDEN 334


>BC117678-1|AAI17679.1|  581|Homo sapiens ANKHD1 protein protein.
          Length = 581

 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 87/346 (25%), Positives = 145/346 (41%), Gaps = 21/346 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKL 274
           ++ +  EG   L  A   G  +  ++ L   A +  + +    TP+  A + G LDIVKL
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 275 MFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           +         A + S      T +  A      +IV  L+NEG++I   ++   +PL+ A
Sbjct: 291 LLLHD-----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           AS         L+  GA I       +     +    G L+      +   ++       
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE------ 399

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD 454
            K +   + L  A  +GH+     L+  GA +N+  ++ ESPL  AA  G    A  L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 455 SDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSG 512
                  + E + EG TPL  A+REGH  +V LLL +GA ++   +      L LA   G
Sbjct: 460 RGAN---LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           +++  + L    +     I+   +T L  A+ E     +  LL+ G
Sbjct: 517 FSEVADFLIKAGA----DIELGCSTPLMEASQEGHLELVKYLLASG 558



 Score = 71.7 bits (168), Expect = 1e-11
 Identities = 79/317 (24%), Positives = 134/317 (42%), Gaps = 14/317 (4%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           L  A   GD+ AV   L  G  ++    +  + + LAC+ G  ++ +++  M    +   
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE--- 265

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
               +   +TP+  A+   + +IV  L+   +D+N       + L  A +      V  L
Sbjct: 266 -DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHY 406
           +  GA+I+  + N    L +   + G +E  A    DH    +    NE      S L  
Sbjct: 325 LNEGANIEDHNENGHTPL-MEAASAGHVE-VARVLLDH-GAGINTHSNEFKE---SALTL 378

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A  +GH+  +  L+  GA    K +   + L  A   G    A  LLDS      +N   
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ---VNMPA 435

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHS 525
               +PL +A+  GH  +  LL+ RGA L   +  G  PL  AA  G+ + + LL +  +
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 526 HLLDQIDKDGNTSLHLA 542
           ++  Q ++   T+L LA
Sbjct: 496 NINAQTEETQETALTLA 512



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 69/257 (26%), Positives = 104/257 (40%), Gaps = 10/257 (3%)

Query: 310 VNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           V  L++EG  +N   +E  S L LA S   +     L+ + A+++ +  N  ++  L+  
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG-NKGDITPLMAA 279

Query: 370 NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLK 429
           + G   D       H        +N +  TG + L YA   G +  ++ L+  GA I   
Sbjct: 280 SSGGYLDIVKLLLLHDAD-----VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           N N  +PL  AA  G    A  LLD   G  I   S+    + L +A  +GH  +V  LL
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAG--INTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 490 NRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA   H+       L  A M G+ +   LL    + +    D    + L LA      
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGGHV 451

Query: 549 SSIALLLSMGCRLSYNN 565
              ALL+  G  L   N
Sbjct: 452 ELAALLIERGANLEEVN 468



 Score = 58.0 bits (134), Expect = 2e-07
 Identities = 68/302 (22%), Positives = 123/302 (40%), Gaps = 21/302 (6%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AA SG   D ++L L   + +  +   G TA   A A    +I+  + N   ++   +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSV-LNEKCQAPIHMATELNKVSVLQVFAKYK 136
             G+TPL  A     ++    LL      +   NE  ++ + +A     + +++   +  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
           +  +     +   TAL  A +  H   A++L+ D  A+   P ++   P+  AA      
Sbjct: 396 A--DQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
              + +    +RG   E++    ++EG  PL  A   G  + V L L  GA I+ Q  + 
Sbjct: 453 LAALLI----ERGANLEEV----NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 257 -STPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN 315
             T + LAC  G  ++   +       +  C         TP+  A+   H E+V YL+ 
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIELGC--------STPLMEASQEGHLELVKYLLA 556

Query: 316 EG 317
            G
Sbjct: 557 SG 558



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 61/268 (22%), Positives = 107/268 (39%), Gaps = 16/268 (5%)

Query: 54  ASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKC 113
           AS+    +I+  +  +  D+N++   GNT L  A     +D ++ LL +       NE  
Sbjct: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 114 QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLD 172
             P+  A     V V +V   + +  N +   E   +AL  A    H D+   +L    D
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGAD 397

Query: 173 AEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVH 232
            E K   +  +  + EA  +       + L  G Q        +++  +    PL  A  
Sbjct: 398 QEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQ--------VNMPADSFESPLTLAAC 447

Query: 233 GGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDV 292
           GG ++   L +  GA +     +  TP+  A  +G  ++V L+   Q    +A       
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA-QGANINAQTEETQE 506

Query: 293 QKMTPIHCAAMFDHPEIVNYLINEGSDI 320
             +T + C   F   E+ ++LI  G+DI
Sbjct: 507 TALT-LACCGGFS--EVADFLIKAGADI 531


>BC062346-1|AAH62346.1|  361|Homo sapiens ankyrin repeat domain 16
           protein.
          Length = 361

 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 37/314 (11%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H A   G  D++  +      +  A  T+ D ++  P+H AA   H + V YL+  G
Sbjct: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEA--TNRDYKR--PLHEAASMGHRDCVRYLLGRG 94

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH------------ 365
           + ++ L K   +PL++A +R     +  L+  GA+  LK+ +  N  H            
Sbjct: 95  AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQ 154

Query: 366 --LVVMNGG--------RLEDFAASCKDHCE--KSLLQLL----NEKDNTGCSPLHYASR 409
             L V  G         R     A+   H E  K LL+      + +DN G + L  A +
Sbjct: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214

Query: 410 EGHIRSLENLI-RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
            GHI     L+   GAC++ +++     LH AA  G+   A + L S+ G  +   +   
Sbjct: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQ-DEAIRFLVSELGVDVDVRATST 273

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
            LT LH A++EGHT  +  LL+ GA ++ +D   R+ LHLA    +    + L  + S L
Sbjct: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFL--LQSGL 331

Query: 528 LDQIDKDGNTSLHL 541
            D  D  G  +  L
Sbjct: 332 KDSEDITGTLAQQL 345



 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 72/292 (24%), Positives = 119/292 (40%), Gaps = 14/292 (4%)

Query: 47  GRTAAHQASARNNTNILHFINNYAG-DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           G T  H A+   + ++L ++    G D+ A +     PLH A      D + YLL +   
Sbjct: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
              L +    P+ MA     + V+Q   ++ +  N     + G  + H A+     L  +
Sbjct: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLILQ 154

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            L+T     WK        P+H AA +     ++V L     + C  E      DN G  
Sbjct: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL-----KRCQYEP--DYRDNCGVT 207

Query: 226 PLHSAVHGGDIKAVELCL-RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
            L  A+  G I    L L   GA +S +    +  +H A   G  + ++ + +    +  
Sbjct: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
              TS     +T +H AA   H   +  L++ G+DIN  D++ RS L LA +
Sbjct: 268 VRATS---THLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACA 316



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 88/288 (30%), Positives = 130/288 (45%), Gaps = 21/288 (7%)

Query: 296 TPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
           T +HCAA   H +++ YL    G DI   +++ + PL  AAS      V  L+  GA + 
Sbjct: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98

Query: 355 -LKDINSRNVLHLVVM-NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            LK  +   ++      N G +++         E     LL  KD  G +  H ASREG 
Sbjct: 99  CLKKADWTPLMMACTRKNLGVIQELV-------EHGANPLLKNKD--GWNSFHIASREGD 149

Query: 413 IRSLENLIRL--GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              L+ L+ +  GA    ++    +PLH AA +G       LL   +  +  +  D  G+
Sbjct: 150 PLILQYLLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLK--RCQYEPDYRDNCGV 206

Query: 471 TPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           T L  A + GH  V  LLL+  GA L   D  G   LH AA++G  + I  L S     +
Sbjct: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266

Query: 529 D-QIDKDGNTSLHLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYA 574
           D +      T+LH A  E   S+I  LLS+G  + S +  + SA+  A
Sbjct: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 84/311 (27%), Positives = 129/311 (41%), Gaps = 27/311 (8%)

Query: 145 GEHGRTALHFAAIHDH-DLCAKIL-ITDLDAEWKKPCNNGY-YPIHEAAKNASSRTIEVF 201
           G  G T LH AA H H D+ A +     +D E     N  Y  P+HEAA       +   
Sbjct: 34  GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIE---ATNRDYKRPLHEAASMGHRDCVRYL 90

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G    C ++            PL  A    ++  ++  +  GA    +  D     H
Sbjct: 91  LGRGAAVDCLKK--------ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFH 142

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           +A  +G   I++ + T+ P    A  T   +++ TP+H AAM  H E V  L+       
Sbjct: 143 IASREGDPLILQYLLTVCP---GAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKRCQYEP 198

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLI--RLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
                     L+ A + G   V  L+    GA +  +D      LH   + G   +D A 
Sbjct: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTG---QDEA- 254

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             +    +  + +     +T  + LHYA++EGH  +++ L+ LGA IN K+  N S LH 
Sbjct: 255 -IRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL 313

Query: 440 AARYGRFHTAC 450
           A   G+ H AC
Sbjct: 314 ACA-GQ-HLAC 322



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 45/158 (28%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 400 GCSPLHYASREGHIRSLENLIRL-GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
           G + LH A+R GH   L  L    G  I   N + + PLH AA  G       LL     
Sbjct: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL-LHRDHNGRNPLHLAAMSGYTKTI 517
              + ++D    TPL +A    +  V+  L+  GA  L ++ +G N  H+A+  G    +
Sbjct: 97  VDCLKKADW---TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153

Query: 518 ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           + L +V         K   T LH A M     ++ +LL
Sbjct: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 43  RDGRGRTAAHQASARNNTNILHFI-NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           RD  G TA   A    + ++   + + +   L+A+D+ G   LH A      +AI +L+ 
Sbjct: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260

Query: 102 Q-HVETSVLNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD 159
           +  V+  V         +H A +    S +Q      +  ++N   E  R+ALH A    
Sbjct: 261 ELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGA--DINSKDEKNRSALHLACAGQ 318

Query: 160 HDLCAKILI 168
           H  CAK L+
Sbjct: 319 HLACAKFLL 327



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 3/104 (2%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPS-RLAVR-DGRGRTAAHQASARNNTNIL 63
           LS    +      +AA +G  D+ +R  +SE    + VR      TA H A+   +T+ +
Sbjct: 232 LSAEDSLGAQALHRAAVTGQ-DEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTI 290

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
             + +   D+N+KD    + LH+A   + L   ++LLQ  ++ S
Sbjct: 291 QTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDS 334


>AL137186-4|CAI41072.1|  361|Homo sapiens ankyrin repeat domain 16
           protein.
          Length = 361

 Score = 79.4 bits (187), Expect = 7e-14
 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 37/314 (11%)

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H A   G  D++  +      +  A  T+ D ++  P+H AA   H + V YL+  G
Sbjct: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEA--TNRDYKR--PLHEAASMGHRDCVRYLLGRG 94

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH------------ 365
           + ++ L K   +PL++A +R     +  L+  GA+  LK+ +  N  H            
Sbjct: 95  AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQ 154

Query: 366 --LVVMNGG--------RLEDFAASCKDHCE--KSLLQLL----NEKDNTGCSPLHYASR 409
             L V  G         R     A+   H E  K LL+      + +DN G + L  A +
Sbjct: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214

Query: 410 EGHIRSLENLI-RLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGE 468
            GHI     L+   GAC++ +++     LH AA  G+   A + L S+ G  +   +   
Sbjct: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQ-DEAIRFLVSELGVDVDVRATST 273

Query: 469 GLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHL 527
            LT LH A++EGHT  +  LL+ GA ++ +D   R+ LHLA    +    + L  + S L
Sbjct: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFL--LQSGL 331

Query: 528 LDQIDKDGNTSLHL 541
            D  D  G  +  L
Sbjct: 332 KDSEDITGTLAQQL 345



 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 72/292 (24%), Positives = 119/292 (40%), Gaps = 14/292 (4%)

Query: 47  GRTAAHQASARNNTNILHFINNYAG-DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           G T  H A+   + ++L ++    G D+ A +     PLH A      D + YLL +   
Sbjct: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
              L +    P+ MA     + V+Q   ++ +  N     + G  + H A+     L  +
Sbjct: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLILQ 154

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
            L+T     WK        P+H AA +     ++V L     + C  E      DN G  
Sbjct: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL-----KRCQYEP--DYRDNCGVT 207

Query: 226 PLHSAVHGGDIKAVELCL-RSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
            L  A+  G I    L L   GA +S +    +  +H A   G  + ++ + +    +  
Sbjct: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAAS 336
              TS     +T +H AA   H   +  L++ G+DIN  D++ RS L LA +
Sbjct: 268 VRATS---THLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACA 316



 Score = 75.8 bits (178), Expect = 9e-13
 Identities = 88/288 (30%), Positives = 130/288 (45%), Gaps = 21/288 (7%)

Query: 296 TPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ 354
           T +HCAA   H +++ YL    G DI   +++ + PL  AAS      V  L+  GA + 
Sbjct: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98

Query: 355 -LKDINSRNVLHLVVM-NGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            LK  +   ++      N G +++         E     LL  KD  G +  H ASREG 
Sbjct: 99  CLKKADWTPLMMACTRKNLGVIQELV-------EHGANPLLKNKD--GWNSFHIASREGD 149

Query: 413 IRSLENLIRL--GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
              L+ L+ +  GA    ++    +PLH AA +G       LL   +  +  +  D  G+
Sbjct: 150 PLILQYLLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLK--RCQYEPDYRDNCGV 206

Query: 471 TPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLL 528
           T L  A + GH  V  LLL+  GA L   D  G   LH AA++G  + I  L S     +
Sbjct: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266

Query: 529 D-QIDKDGNTSLHLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYA 574
           D +      T+LH A  E   S+I  LLS+G  + S +  + SA+  A
Sbjct: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 84/311 (27%), Positives = 129/311 (41%), Gaps = 27/311 (8%)

Query: 145 GEHGRTALHFAAIHDH-DLCAKIL-ITDLDAEWKKPCNNGY-YPIHEAAKNASSRTIEVF 201
           G  G T LH AA H H D+ A +     +D E     N  Y  P+HEAA       +   
Sbjct: 34  GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIE---ATNRDYKRPLHEAASMGHRDCVRYL 90

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVH 261
           L  G    C ++            PL  A    ++  ++  +  GA    +  D     H
Sbjct: 91  LGRGAAVDCLKK--------ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFH 142

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDIN 321
           +A  +G   I++ + T+ P    A  T   +++ TP+H AAM  H E V  L+       
Sbjct: 143 IASREGDPLILQYLLTVCP---GAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKRCQYEP 198

Query: 322 PLDKERRSPLLLAASRAGWRTVHTLI--RLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
                     L+ A + G   V  L+    GA +  +D      LH   + G   +D A 
Sbjct: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTG---QDEA- 254

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
             +    +  + +     +T  + LHYA++EGH  +++ L+ LGA IN K+  N S LH 
Sbjct: 255 -IRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL 313

Query: 440 AARYGRFHTAC 450
           A   G+ H AC
Sbjct: 314 ACA-GQ-HLAC 322



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 45/158 (28%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 400 GCSPLHYASREGHIRSLENLIRL-GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKG 458
           G + LH A+R GH   L  L    G  I   N + + PLH AA  G       LL     
Sbjct: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96

Query: 459 TFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL-LHRDHNGRNPLHLAAMSGYTKTI 517
              + ++D    TPL +A    +  V+  L+  GA  L ++ +G N  H+A+  G    +
Sbjct: 97  VDCLKKADW---TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153

Query: 518 ELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLL 555
           + L +V         K   T LH A M     ++ +LL
Sbjct: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 43  RDGRGRTAAHQASARNNTNILHFI-NNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           RD  G TA   A    + ++   + + +   L+A+D+ G   LH A      +AI +L+ 
Sbjct: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260

Query: 102 Q-HVETSVLNEKCQ-APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD 159
           +  V+  V         +H A +    S +Q      +  ++N   E  R+ALH A    
Sbjct: 261 ELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGA--DINSKDEKNRSALHLACAGQ 318

Query: 160 HDLCAKILI 168
           H  CAK L+
Sbjct: 319 HLACAKFLL 327



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 3/104 (2%)

Query: 6   LSTSTKVNLSFFVQAAESGNVDDFMRLYLSEPS-RLAVR-DGRGRTAAHQASARNNTNIL 63
           LS    +      +AA +G  D+ +R  +SE    + VR      TA H A+   +T+ +
Sbjct: 232 LSAEDSLGAQALHRAAVTGQ-DEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTI 290

Query: 64  HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
             + +   D+N+KD    + LH+A   + L   ++LLQ  ++ S
Sbjct: 291 QTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDS 334


>AL035288-1|CAA22892.1|  671|Homo sapiens hypothetical protein
           protein.
          Length = 671

 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 57/172 (33%), Positives = 83/172 (48%), Gaps = 7/172 (4%)

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACI-NLKNNNNESPLHFAARYGRFHTACQLL 453
           +KDN+G + LH  +R GH + +  L+  G        +    P+H+AA  G F +   L+
Sbjct: 1   DKDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 60

Query: 454 DS-DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLAAM 510
               +G   +N     G TPL++A +EGH  V   L+   GA  H R H+G  PLH AA 
Sbjct: 61  RHYPEG---VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 117

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
            G++  I  L S     L + DKDG T+ H A        ++ LL  G  +S
Sbjct: 118 MGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGEIS 169



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 43/151 (28%), Positives = 78/151 (51%), Gaps = 4/151 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTACQ 451
           +N +   G +PL+ A +EGH+   + L++  GA  + + ++  +PLH AA+ G       
Sbjct: 67  VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVW 126

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMS 511
           L+     +  ++E D +G T  H A+  GH++V+  LL  G  +  D  G   L+ AA +
Sbjct: 127 LVSCTDVS--LSEQDKDGATATHFAASRGHSKVLSWLLLHGGEISADLWGGTALYDAAEN 184

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           G  +  ++L  V+   L+  D+DG  +  L+
Sbjct: 185 GELECCQIL-VVNGAELEVRDRDGYAAADLS 214



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 7/151 (4%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAK-ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPK 281
           G +P+H A   GD  ++ L +R   + ++ Q  + +TP++LAC +G L++ + +      
Sbjct: 40  GALPIHYAAAKGDFPSLRLLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGA 99

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN-EGSDINPLDKERRSPLLLAASRAGW 340
           + HA         MTP+H AA   H  ++ +L++     ++  DK+  +    AASR   
Sbjct: 100 DPHARAH----DGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHS 155

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           + +  L+  G +I   D+     L+    NG
Sbjct: 156 KVLSWLLLHGGEIS-ADLWGGTALYDAAENG 185



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 63/263 (23%), Positives = 111/263 (42%), Gaps = 20/263 (7%)

Query: 296 TPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLLAASRAGWRTVHTLIR---LGA 351
           T +H  A F HP++VN+L++  G D          P+  AA++  + ++  L+R    G 
Sbjct: 8   TVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHYPEGV 67

Query: 352 DIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
           + Q K  N    L+L     G LE         C        + + + G +PLH A++ G
Sbjct: 68  NAQTK--NGATPLYLACQE-GHLE-VTQYLVQECGAD----PHARAHDGMTPLHAAAQMG 119

Query: 412 HIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           H   +  L+      ++ ++ +  +  HFAA  G       LL    G      +D  G 
Sbjct: 120 HSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLL-LHGGEI---SADLWGG 175

Query: 471 TPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L+ A+  G      +L+  GA L  RD +G     L+  +G++     L +V +  ++
Sbjct: 176 TALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVENLSME 235

Query: 530 Q--IDKDGNTSLHLATMENKPSS 550
              + +D +  L     ++  SS
Sbjct: 236 HCVLSRDPSVELEAKQPDSGMSS 258



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 49/251 (19%), Positives = 100/251 (39%), Gaps = 12/251 (4%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAG-DLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           +D  G T  H  +   +  +++++ ++ G D  A  + G  P+H A       ++  L++
Sbjct: 2   KDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVR 61

Query: 102 QHVE-TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
            + E  +   +    P+++A +   + V Q   + +   + +     G T LH AA   H
Sbjct: 62  HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQ-ECGADPHARAHDGMTPLHAAAQMGH 120

Query: 161 DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYD 220
                 L++  D    +   +G    H AA    S+ +   L  G +        IS  D
Sbjct: 121 SPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGE--------ISA-D 171

Query: 221 NEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
             G   L+ A   G+++  ++ + +GA++  +  D      L+   G       + T++ 
Sbjct: 172 LWGGTALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVEN 231

Query: 281 KEKHACLTSCD 291
                C+ S D
Sbjct: 232 LSMEHCVLSRD 242


>AL021920-3|CAI19632.1|  671|Homo sapiens espin pseudogene protein.
          Length = 671

 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 57/172 (33%), Positives = 83/172 (48%), Gaps = 7/172 (4%)

Query: 395 EKDNTGCSPLHYASREGHIRSLENLIRLGACI-NLKNNNNESPLHFAARYGRFHTACQLL 453
           +KDN+G + LH  +R GH + +  L+  G        +    P+H+AA  G F +   L+
Sbjct: 1   DKDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 60

Query: 454 DS-DKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNR-GALLH-RDHNGRNPLHLAAM 510
               +G   +N     G TPL++A +EGH  V   L+   GA  H R H+G  PLH AA 
Sbjct: 61  RHYPEG---VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 117

Query: 511 SGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLS 562
            G++  I  L S     L + DKDG T+ H A        ++ LL  G  +S
Sbjct: 118 MGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGEIS 169



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 43/151 (28%), Positives = 78/151 (51%), Gaps = 4/151 (2%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTACQ 451
           +N +   G +PL+ A +EGH+   + L++  GA  + + ++  +PLH AA+ G       
Sbjct: 67  VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVW 126

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMS 511
           L+     +  ++E D +G T  H A+  GH++V+  LL  G  +  D  G   L+ AA +
Sbjct: 127 LVSCTDVS--LSEQDKDGATATHFAASRGHSKVLSWLLLHGGEISADLWGGTALYDAAEN 184

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           G  +  ++L  V+   L+  D+DG  +  L+
Sbjct: 185 GELECCQIL-VVNGAELEVRDRDGYAAADLS 214



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 7/151 (4%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAK-ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPK 281
           G +P+H A   GD  ++ L +R   + ++ Q  + +TP++LAC +G L++ + +      
Sbjct: 40  GALPIHYAAAKGDFPSLRLLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGA 99

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLIN-EGSDINPLDKERRSPLLLAASRAGW 340
           + HA         MTP+H AA   H  ++ +L++     ++  DK+  +    AASR   
Sbjct: 100 DPHARAH----DGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHS 155

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNG 371
           + +  L+  G +I   D+     L+    NG
Sbjct: 156 KVLSWLLLHGGEIS-ADLWGGTALYDAAENG 185



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 63/263 (23%), Positives = 111/263 (42%), Gaps = 20/263 (7%)

Query: 296 TPIHCAAMFDHPEIVNYLINE-GSDINPLDKERRSPLLLAASRAGWRTVHTLIR---LGA 351
           T +H  A F HP++VN+L++  G D          P+  AA++  + ++  L+R    G 
Sbjct: 8   TVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHYPEGV 67

Query: 352 DIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
           + Q K  N    L+L     G LE         C        + + + G +PLH A++ G
Sbjct: 68  NAQTK--NGATPLYLACQE-GHLE-VTQYLVQECGAD----PHARAHDGMTPLHAAAQMG 119

Query: 412 HIRSLENLIR-LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           H   +  L+      ++ ++ +  +  HFAA  G       LL    G      +D  G 
Sbjct: 120 HSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLL-LHGGEI---SADLWGG 175

Query: 471 TPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLD 529
           T L+ A+  G      +L+  GA L  RD +G     L+  +G++     L +V +  ++
Sbjct: 176 TALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVENLSME 235

Query: 530 Q--IDKDGNTSLHLATMENKPSS 550
              + +D +  L     ++  SS
Sbjct: 236 HCVLSRDPSVELEAKQPDSGMSS 258



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 49/251 (19%), Positives = 100/251 (39%), Gaps = 12/251 (4%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAG-DLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           +D  G T  H  +   +  +++++ ++ G D  A  + G  P+H A       ++  L++
Sbjct: 2   KDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVR 61

Query: 102 QHVE-TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDH 160
            + E  +   +    P+++A +   + V Q   + +   + +     G T LH AA   H
Sbjct: 62  HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQ-ECGADPHARAHDGMTPLHAAAQMGH 120

Query: 161 DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYD 220
                 L++  D    +   +G    H AA    S+ +   L  G +        IS  D
Sbjct: 121 SPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGE--------ISA-D 171

Query: 221 NEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQP 280
             G   L+ A   G+++  ++ + +GA++  +  D      L+   G       + T++ 
Sbjct: 172 LWGGTALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVEN 231

Query: 281 KEKHACLTSCD 291
                C+ S D
Sbjct: 232 LSMEHCVLSRD 242


>AK127855-1|BAC87163.1|  337|Homo sapiens protein ( Homo sapiens
           cDNA FLJ45958 fis, clone PLACE7011559, highly  similar
           to Death-associated protein kinase 1 (EC 2.7.1.-). ).
          Length = 337

 Score = 79.0 bits (186), Expect = 9e-14
 Identities = 53/163 (32%), Positives = 78/163 (47%), Gaps = 5/163 (3%)

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH A+R GH    + L   G+  N+++   E+PLH AA +G +  A  L ++      +N
Sbjct: 3   LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCN---VN 59

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHS 522
             + EG TPL  AS  G+  +V  L   GA L+  D +G   LHLA      + I+ L S
Sbjct: 60  IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 119

Query: 523 VHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
                +D  D+ GNT LH+A  +     +  L    C L  +N
Sbjct: 120 -QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 161



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 52/166 (31%), Positives = 80/166 (48%), Gaps = 5/166 (3%)

Query: 394 NEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
           N +D    +PLH A+  GH    + L   G  +N+KN   E+PL  A+  G +H   + L
Sbjct: 26  NIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIKNREGETPLLTASARG-YHDIVECL 84

Query: 454 DSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALL-HRDHNGRNPLHLAAMSG 512
            ++ G  + N  D +G   LH+A R     V+  LL++G  + ++D +G  PLH+A   G
Sbjct: 85  -AEHGADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDG 142

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
               +  L   + +L D  +K G T LHLA        +  L  MG
Sbjct: 143 NMPIVVALCEANCNL-DISNKYGRTPLHLAANNGILDVVRYLCLMG 187



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 60/238 (25%), Positives = 97/238 (40%), Gaps = 15/238 (6%)

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G  D+ +L+ +             D ++ TP+HCAA   H  +   L   G +
Sbjct: 3   LHVAARYGHADVAQLLCSFGSNPNIQ-----DKEEETPLHCAAWHGHYSVAKALCEAGCN 57

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           +N  ++E  +PLL A++R     V  L   GAD+   D +    LHL V    ++E    
Sbjct: 58  VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR-CQMEVIKT 116

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
                C       ++ +D  G +PLH A ++G++  +  L      +++ N    +PLH 
Sbjct: 117 LLSQGC------FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 170

Query: 440 AARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR 497
           AA  G       L         +     +G T   +A  E H  V  LL       HR
Sbjct: 171 AANNGILDVVRYLCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 225



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 64/225 (28%), Positives = 97/225 (43%), Gaps = 13/225 (5%)

Query: 332 LLAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L  A+R G   V  L+   G++  ++D      LH    +G       A C+  C     
Sbjct: 3   LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG-HYSVAKALCEAGCN---- 57

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
             +N K+  G +PL  AS  G+   +E L   GA +N  + +    LH A R  +     
Sbjct: 58  --VNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 115

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAA 509
            LL   +G F+ +  D  G TPLH+A ++G+  +V  L      L   +  GR PLHLAA
Sbjct: 116 TLLS--QGCFV-DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAA 172

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALL 554
            +G    +  L  +    ++ +  DG T+  LA  E       LL
Sbjct: 173 NNGILDVVRYL-CLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 216



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 58/236 (24%), Positives = 93/236 (39%), Gaps = 16/236 (6%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWK 176
           +H+A       V Q+   + S  N+    E   T LH AA H H   AK L  +      
Sbjct: 3   LHVAARYGHADVAQLLCSFGSNPNIQDKEEE--TPLHCAAWHGHYSVAKALC-EAGCNVN 59

Query: 177 KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI 236
                G  P+  A+       +E   + G          ++  D +G++ LH AV    +
Sbjct: 60  IKNREGETPLLTASARGYHDIVECLAEHGAD--------LNACDKDGHIALHLAVRRCQM 111

Query: 237 KAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMT 296
           + ++  L  G  +  Q    +TP+H+AC  G + IV  +      E +  L   +    T
Sbjct: 112 EVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALC-----EANCNLDISNKYGRT 166

Query: 297 PIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGAD 352
           P+H AA     ++V YL   G+ +  L  + ++   LA S         L RL  D
Sbjct: 167 PLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 222



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 2/115 (1%)

Query: 42  VRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           +++  G T    ASAR   +I+  +  +  DLNA D  G+  LH+AV    ++ I+ LL 
Sbjct: 60  IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 119

Query: 102 QHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q       +     P+H+A +   + +  V A  ++  N++   ++GRT LH AA
Sbjct: 120 QGCFVDYQDRHGNTPLHVACKDGNMPI--VVALCEANCNLDISNKYGRTPLHLAA 172



 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 44/236 (18%), Positives = 95/236 (40%), Gaps = 14/236 (5%)

Query: 50  AAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVL 109
           A H A+   + ++   + ++  + N +D    TPLH A  +      + L +     ++ 
Sbjct: 2   ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIK 61

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIH-DHDLCAKILI 168
           N + + P+  A+      +++  A++ +  ++N   + G  ALH A      ++   +L 
Sbjct: 62  NREGETPLLTASARGYHDIVECLAEHGA--DLNACDKDGHIALHLAVRRCQMEVIKTLLS 119

Query: 169 TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLH 228
                +++    +G  P+H A K+ +   +           C     + + +  G  PLH
Sbjct: 120 QGCFVDYQD--RHGNTPLHVACKDGNMPIVVAL--------CEANCNLDISNKYGRTPLH 169

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
            A + G +  V      GA +     D  T   LA ++    +  L+  ++ K+ H
Sbjct: 170 LAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLR-KDTH 224



 Score = 44.8 bits (101), Expect = 0.002
 Identities = 39/173 (22%), Positives = 72/173 (41%), Gaps = 4/173 (2%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+ D   +L  S  S   ++D    T  H A+   + ++   +     ++N K+  
Sbjct: 6   AARYGHAD-VAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIKNRE 64

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G TPL  A      D +E L +   + +  ++     +H+A    ++ V++     +  F
Sbjct: 65  GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS-QGCF 123

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
            V+    HG T LH  A  D ++   + + + +         G  P+H AA N
Sbjct: 124 -VDYQDRHGNTPLH-VACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN 174



 Score = 42.7 bits (96), Expect = 0.007
 Identities = 32/147 (21%), Positives = 61/147 (41%), Gaps = 2/147 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A +    D +       + L   D  G  A H A  R    ++  + +    ++ +D  G
Sbjct: 72  ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG 131

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
           NTPLHVA ++  +  +  L + +    + N+  + P+H+A     + V++      +  +
Sbjct: 132 NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA--S 189

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKIL 167
           V      G+TA   A    H+  A +L
Sbjct: 190 VEALTTDGKTAEDLARSEQHEHVAGLL 216



 Score = 32.7 bits (71), Expect = 8.0
 Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 1/63 (1%)

Query: 505 LHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
           LH+AA  G+    +LL S  S+   Q DK+  T LH A      S    L   GC ++  
Sbjct: 3   LHVAARYGHADVAQLLCSFGSNPNIQ-DKEEETPLHCAAWHGHYSVAKALCEAGCNVNIK 61

Query: 565 NMD 567
           N +
Sbjct: 62  NRE 64


>BX005460-4|CAM26150.1|  297|Homo sapiens euchromatic histone-lysine
           N-methyltransferase 2 protein.
          Length = 297

 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 10/207 (4%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K TP+H AA     EI + L+  G++IN +DK++R+PL+ A           +++ G  +
Sbjct: 2   KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 61

Query: 354 QLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQL------LNEKDNTGCSPLHY 406
             K+ +    LH     G   +     S       +  QL       + +D+ G +P+ +
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+   HI  +  L+  GA + L +N     LH+A+  G    A  LL++      +N   
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY-- 179

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGA 493
             G TPLHIA+RE +   V L L+RGA
Sbjct: 180 -HGDTPLHIAARESYHDCVLLFLSRGA 205



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 13/187 (6%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 28  INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 87

Query: 453 LDSDK-----------GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNG 501
           L + +            +   +  D  G TP+  A+   H  V+ +LL RGA +    N 
Sbjct: 88  LSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 147

Query: 502 RN-PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            N  LH A+ +G     E+L +     L  ++  G+T LH+A  E+    + L LS G  
Sbjct: 148 ENICLHWASFTGSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206

Query: 561 LSYNNMD 567
               N +
Sbjct: 207 PELRNKE 213



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 53/225 (23%), Positives = 96/225 (42%), Gaps = 28/225 (12%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 5   PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 59

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DIN-------------PLDKERRSPL 331
           C+ S +    T +H AA   + E+V+ L++ G  D+N             P D    +P+
Sbjct: 60  CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPI 119

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLL 390
           + AA       +  L+  GAD+ L D      LH     G   + +   + +  C+    
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD---- 173

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
             L+  +  G +PLH A+RE +   +   +  GA   L+N   ++
Sbjct: 174 --LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216



 Score = 53.6 bits (123), Expect = 4e-06
 Identities = 53/209 (25%), Positives = 92/209 (44%), Gaps = 23/209 (11%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           TPLH A +  +++    LLQ     + ++++ + P+  A   N + V +   +      V
Sbjct: 4   TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC--V 61

Query: 142 NQGGEHGRTALHFAA-IHDHDLCAKILIT---DLDAEWKKPC---------NNGYYPIHE 188
               E G T LH AA I + ++ + +L T   D++A+ + P          + G+ PI  
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA++     I + L        TR   ++L DNE N+ LH A   G     E+ L +   
Sbjct: 122 AAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 173

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFT 277
           +    +   TP+H+A  +   D V L  +
Sbjct: 174 LHAVNYHGDTPLHIAARESYHDCVLLFLS 202



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 120 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 178

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 179 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 213


>AL671762-12|CAI18225.2|  297|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 297

 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 10/207 (4%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K TP+H AA     EI + L+  G++IN +DK++R+PL+ A           +++ G  +
Sbjct: 2   KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 61

Query: 354 QLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQL------LNEKDNTGCSPLHY 406
             K+ +    LH     G   +     S       +  QL       + +D+ G +P+ +
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+   HI  +  L+  GA + L +N     LH+A+  G    A  LL++      +N   
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY-- 179

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGA 493
             G TPLHIA+RE +   V L L+RGA
Sbjct: 180 -HGDTPLHIAARESYHDCVLLFLSRGA 205



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 13/187 (6%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 28  INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 87

Query: 453 LDSDK-----------GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNG 501
           L + +            +   +  D  G TP+  A+   H  V+ +LL RGA +    N 
Sbjct: 88  LSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 147

Query: 502 RN-PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            N  LH A+ +G     E+L +     L  ++  G+T LH+A  E+    + L LS G  
Sbjct: 148 ENICLHWASFTGSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206

Query: 561 LSYNNMD 567
               N +
Sbjct: 207 PELRNKE 213



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 53/225 (23%), Positives = 96/225 (42%), Gaps = 28/225 (12%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 5   PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 59

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DIN-------------PLDKERRSPL 331
           C+ S +    T +H AA   + E+V+ L++ G  D+N             P D    +P+
Sbjct: 60  CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPI 119

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLL 390
           + AA       +  L+  GAD+ L D      LH     G   + +   + +  C+    
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD---- 173

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
             L+  +  G +PLH A+RE +   +   +  GA   L+N   ++
Sbjct: 174 --LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216



 Score = 53.6 bits (123), Expect = 4e-06
 Identities = 53/209 (25%), Positives = 92/209 (44%), Gaps = 23/209 (11%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           TPLH A +  +++    LLQ     + ++++ + P+  A   N + V +   +      V
Sbjct: 4   TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC--V 61

Query: 142 NQGGEHGRTALHFAA-IHDHDLCAKILIT---DLDAEWKKPC---------NNGYYPIHE 188
               E G T LH AA I + ++ + +L T   D++A+ + P          + G+ PI  
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA++     I + L        TR   ++L DNE N+ LH A   G     E+ L +   
Sbjct: 122 AAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 173

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFT 277
           +    +   TP+H+A  +   D V L  +
Sbjct: 174 LHAVNYHGDTPLHIAARESYHDCVLLFLS 202



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 120 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 178

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 179 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 213


>AL662834-23|CAM24991.1|  297|Homo sapiens euchromatic
           histone-lysine N-methyltransferase 2 protein.
          Length = 297

 Score = 78.6 bits (185), Expect = 1e-13
 Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 10/207 (4%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K TP+H AA     EI + L+  G++IN +DK++R+PL+ A           +++ G  +
Sbjct: 2   KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 61

Query: 354 QLKDINSRNVLHLVVMNGG-RLEDFAASCKDHCEKSLLQL------LNEKDNTGCSPLHY 406
             K+ +    LH     G   +     S       +  QL       + +D+ G +P+ +
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 407 ASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESD 466
           A+   HI  +  L+  GA + L +N     LH+A+  G    A  LL++      +N   
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY-- 179

Query: 467 GEGLTPLHIASREGHTRVVHLLLNRGA 493
             G TPLHIA+RE +   V L L+RGA
Sbjct: 180 -HGDTPLHIAARESYHDCVLLFLSRGA 205



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 13/187 (6%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 28  INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 87

Query: 453 LDSDK-----------GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNG 501
           L + +            +   +  D  G TP+  A+   H  V+ +LL RGA +    N 
Sbjct: 88  LSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNE 147

Query: 502 RN-PLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCR 560
            N  LH A+ +G     E+L +     L  ++  G+T LH+A  E+    + L LS G  
Sbjct: 148 ENICLHWASFTGSAAIAEVLLNARCD-LHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206

Query: 561 LSYNNMD 567
               N +
Sbjct: 207 PELRNKE 213



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 53/225 (23%), Positives = 96/225 (42%), Gaps = 28/225 (12%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 5   PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 59

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DIN-------------PLDKERRSPL 331
           C+ S +    T +H AA   + E+V+ L++ G  D+N             P D    +P+
Sbjct: 60  CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPI 119

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGR-LEDFAASCKDHCEKSLL 390
           + AA       +  L+  GAD+ L D      LH     G   + +   + +  C+    
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR--CD---- 173

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES 435
             L+  +  G +PLH A+RE +   +   +  GA   L+N   ++
Sbjct: 174 --LHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216



 Score = 53.6 bits (123), Expect = 4e-06
 Identities = 53/209 (25%), Positives = 92/209 (44%), Gaps = 23/209 (11%)

Query: 82  TPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNV 141
           TPLH A +  +++    LLQ     + ++++ + P+  A   N + V +   +      V
Sbjct: 4   TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC--V 61

Query: 142 NQGGEHGRTALHFAA-IHDHDLCAKILIT---DLDAEWKKPC---------NNGYYPIHE 188
               E G T LH AA I + ++ + +L T   D++A+ + P          + G+ PI  
Sbjct: 62  YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA++     I + L        TR   ++L DNE N+ LH A   G     E+ L +   
Sbjct: 122 AAEHKHIEVIRMLL--------TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCD 173

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFT 277
           +    +   TP+H+A  +   D V L  +
Sbjct: 174 LHAVNYHGDTPLHIAARESYHDCVLLFLS 202



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           + AAE  +++  +R+ L+  + + + D       H AS   +  I   + N   DL+A +
Sbjct: 120 IWAAEHKHIE-VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVN 178

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEK 112
             G+TPLH+A      D +   L +     + N++
Sbjct: 179 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKE 213


>BC050324-1|AAH50324.1|  632|Homo sapiens zinc finger, DHHC-type
           containing 17 protein.
          Length = 632

 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 63/209 (30%), Positives = 103/209 (49%), Gaps = 15/209 (7%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 83  VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 142

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           L+       +I   DGEG + +H+A++ GHT +V  L+ +G  +   D NG  PL  AA 
Sbjct: 143 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAY 199

Query: 511 SGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM- 566
             ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+ 
Sbjct: 200 RTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNIK 257

Query: 567 DMSAIDYAIYYKFPEAALAMVTHEQRAKE 595
             SA+D A   K     + M+ H Q A++
Sbjct: 258 GESALDLAKQRK----NVWMINHLQEARQ 282



 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 50/155 (32%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 87  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 141

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA 338
           Q  +  A  +  D +  + IH AA F H  IV YLI +G D++ +D+   +PL+ AA R 
Sbjct: 142 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRT 201

Query: 339 -GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                   L+     + L D   +N  LH  V+ G
Sbjct: 202 HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 236



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 19/203 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 76  LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 127

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G  HT+       KG   ++
Sbjct: 128 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFG--HTSIVAYLIAKGQ-DVD 184

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 185 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243

Query: 520 LHSVHSHLLDQIDKDGNTSLHLA 542
           L    ++ +D  +  G ++L LA
Sbjct: 244 LLEAGAN-VDAQNIKGESALDLA 265



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 14/184 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 82  DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 141

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEA 189
              KY +  ++  G   G + +H AA   H  + A ++    D +      NG  P+  A
Sbjct: 142 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD--QNGMTPLMWA 197

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A    S      L        T    ++L D    N  LH AV  G+   + L L +GA 
Sbjct: 198 AYRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250

Query: 249 ISTQ 252
           +  Q
Sbjct: 251 VDAQ 254



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 32/161 (19%), Positives = 74/161 (45%), Gaps = 6/161 (3%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGR-GRTAAHQASARNNTNILHFINNY 69
           K N++    AA +  +D  ++ Y+S+ + +    G    T  H A+ + + +++  +  Y
Sbjct: 88  KENVTLLHWAAINNRID-LVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 146

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT-ELNKVSV 128
             D +  D  G + +H+A +      + YL+ +  +  ++++    P+  A    + V  
Sbjct: 147 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 206

Query: 129 LQVFAKYKSLFNVNQGGE-HGRTALHFAAIHDHDLCAKILI 168
            ++   +    +VN G + H  TALH+A +  +     +L+
Sbjct: 207 TRLLLTFN--VSVNLGDKYHKNTALHWAVLAGNTTVISLLL 245



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 43/208 (20%), Positives = 81/208 (38%), Gaps = 14/208 (6%)

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           ++V Q  +   T LH+AAI++     K  I+      +   +    P+H A +      +
Sbjct: 81  YDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV 140

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              +++G           SL D EG   +H A   G    V   +  G  +     +  T
Sbjct: 141 VQLMKYGADP--------SLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 192

Query: 259 PVHLACAQ-GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+  A  +  ++D  +L+ T                K T +H A +  +  +++ L+  G
Sbjct: 193 PLMWAAYRTHSVDPTRLLLTFNVSVN----LGDKYHKNTALHWAVLAGNTTVISLLLEAG 248

Query: 318 SDINPLDKERRSPLLLAASRAG-WRTVH 344
           ++++  + +  S L LA  R   W   H
Sbjct: 249 ANVDAQNIKGESALDLAKQRKNVWMINH 276


>AB097035-1|BAC77388.1|  622|Homo sapiens putative MAPK activating
           protein protein.
          Length = 622

 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 63/209 (30%), Positives = 103/209 (49%), Gaps = 15/209 (7%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 73  VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 132

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           L+       +I   DGEG + +H+A++ GHT +V  L+ +G  +   D NG  PL  AA 
Sbjct: 133 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAY 189

Query: 511 SGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM- 566
             ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+ 
Sbjct: 190 RTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNIK 247

Query: 567 DMSAIDYAIYYKFPEAALAMVTHEQRAKE 595
             SA+D A   K     + M+ H Q A++
Sbjct: 248 GESALDLAKQRK----NVWMINHLQEARQ 272



 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 50/155 (32%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 77  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 131

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA 338
           Q  +  A  +  D +  + IH AA F H  IV YLI +G D++ +D+   +PL+ AA R 
Sbjct: 132 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRT 191

Query: 339 -GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                   L+     + L D   +N  LH  V+ G
Sbjct: 192 HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 226



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 19/203 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 66  LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 117

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G  HT+       KG   ++
Sbjct: 118 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFG--HTSIVAYLIAKGQ-DVD 174

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 175 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 233

Query: 520 LHSVHSHLLDQIDKDGNTSLHLA 542
           L    ++ +D  +  G ++L LA
Sbjct: 234 LLEAGAN-VDAQNIKGESALDLA 255



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 14/184 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 72  DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 131

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEA 189
              KY +  ++  G   G + +H AA   H  + A ++    D +      NG  P+  A
Sbjct: 132 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD--QNGMTPLMWA 187

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A    S      L        T    ++L D    N  LH AV  G+   + L L +GA 
Sbjct: 188 AYRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 240

Query: 249 ISTQ 252
           +  Q
Sbjct: 241 VDAQ 244



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 32/161 (19%), Positives = 74/161 (45%), Gaps = 6/161 (3%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGR-GRTAAHQASARNNTNILHFINNY 69
           K N++    AA +  +D  ++ Y+S+ + +    G    T  H A+ + + +++  +  Y
Sbjct: 78  KENVTLLHWAAINNRID-LVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 136

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT-ELNKVSV 128
             D +  D  G + +H+A +      + YL+ +  +  ++++    P+  A    + V  
Sbjct: 137 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 196

Query: 129 LQVFAKYKSLFNVNQGGE-HGRTALHFAAIHDHDLCAKILI 168
            ++   +    +VN G + H  TALH+A +  +     +L+
Sbjct: 197 TRLLLTFN--VSVNLGDKYHKNTALHWAVLAGNTTVISLLL 235



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 43/208 (20%), Positives = 81/208 (38%), Gaps = 14/208 (6%)

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           ++V Q  +   T LH+AAI++     K  I+      +   +    P+H A +      +
Sbjct: 71  YDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV 130

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              +++G           SL D EG   +H A   G    V   +  G  +     +  T
Sbjct: 131 VQLMKYGADP--------SLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 182

Query: 259 PVHLACAQ-GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+  A  +  ++D  +L+ T                K T +H A +  +  +++ L+  G
Sbjct: 183 PLMWAAYRTHSVDPTRLLLTFNVSVN----LGDKYHKNTALHWAVLAGNTTVISLLLEAG 238

Query: 318 SDINPLDKERRSPLLLAASRAG-WRTVH 344
           ++++  + +  S L LA  R   W   H
Sbjct: 239 ANVDAQNIKGESALDLAKQRKNVWMINH 266


>AB097013-1|BAC77366.1|  622|Homo sapiens putative NFkB activating
           protein protein.
          Length = 622

 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 63/209 (30%), Positives = 103/209 (49%), Gaps = 15/209 (7%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 73  VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 132

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           L+       +I   DGEG + +H+A++ GHT +V  L+ +G  +   D NG  PL  AA 
Sbjct: 133 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAY 189

Query: 511 SGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM- 566
             ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+ 
Sbjct: 190 RTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNIK 247

Query: 567 DMSAIDYAIYYKFPEAALAMVTHEQRAKE 595
             SA+D A   K     + M+ H Q A++
Sbjct: 248 GESALDLAKQRK----NVWMINHLQEARQ 272



 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 50/155 (32%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 77  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 131

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA 338
           Q  +  A  +  D +  + IH AA F H  IV YLI +G D++ +D+   +PL+ AA R 
Sbjct: 132 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRT 191

Query: 339 -GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                   L+     + L D   +N  LH  V+ G
Sbjct: 192 HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 226



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 19/203 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 66  LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 117

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G  HT+       KG   ++
Sbjct: 118 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFG--HTSIVAYLIAKGQ-DVD 174

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 175 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 233

Query: 520 LHSVHSHLLDQIDKDGNTSLHLA 542
           L    ++ +D  +  G ++L LA
Sbjct: 234 LLEAGAN-VDAQNIKGESALDLA 255



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 14/184 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 72  DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 131

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEA 189
              KY +  ++  G   G + +H AA   H  + A ++    D +      NG  P+  A
Sbjct: 132 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD--QNGMTPLMWA 187

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A    S      L        T    ++L D    N  LH AV  G+   + L L +GA 
Sbjct: 188 AYRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 240

Query: 249 ISTQ 252
           +  Q
Sbjct: 241 VDAQ 244



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 32/161 (19%), Positives = 74/161 (45%), Gaps = 6/161 (3%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGR-GRTAAHQASARNNTNILHFINNY 69
           K N++    AA +  +D  ++ Y+S+ + +    G    T  H A+ + + +++  +  Y
Sbjct: 78  KENVTLLHWAAINNRID-LVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 136

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT-ELNKVSV 128
             D +  D  G + +H+A +      + YL+ +  +  ++++    P+  A    + V  
Sbjct: 137 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 196

Query: 129 LQVFAKYKSLFNVNQGGE-HGRTALHFAAIHDHDLCAKILI 168
            ++   +    +VN G + H  TALH+A +  +     +L+
Sbjct: 197 TRLLLTFN--VSVNLGDKYHKNTALHWAVLAGNTTVISLLL 235



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 43/208 (20%), Positives = 81/208 (38%), Gaps = 14/208 (6%)

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           ++V Q  +   T LH+AAI++     K  I+      +   +    P+H A +      +
Sbjct: 71  YDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV 130

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              +++G           SL D EG   +H A   G    V   +  G  +     +  T
Sbjct: 131 VQLMKYGADP--------SLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 182

Query: 259 PVHLACAQ-GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+  A  +  ++D  +L+ T                K T +H A +  +  +++ L+  G
Sbjct: 183 PLMWAAYRTHSVDPTRLLLTFNVSVN----LGDKYHKNTALHWAVLAGNTTVISLLLEAG 238

Query: 318 SDINPLDKERRSPLLLAASRAG-WRTVH 344
           ++++  + +  S L LA  R   W   H
Sbjct: 239 ANVDAQNIKGESALDLAKQRKNVWMINH 266


>AB023163-1|BAA76790.1|  667|Homo sapiens KIAA0946 protein protein.
          Length = 667

 Score = 77.4 bits (182), Expect = 3e-13
 Identities = 63/209 (30%), Positives = 103/209 (49%), Gaps = 15/209 (7%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 118 VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 177

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           L+       +I   DGEG + +H+A++ GHT +V  L+ +G  +   D NG  PL  AA 
Sbjct: 178 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAY 234

Query: 511 SGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM- 566
             ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+ 
Sbjct: 235 RTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNIK 292

Query: 567 DMSAIDYAIYYKFPEAALAMVTHEQRAKE 595
             SA+D A   K     + M+ H Q A++
Sbjct: 293 GESALDLAKQRK----NVWMINHLQEARQ 317



 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 50/155 (32%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 122 DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 176

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA 338
           Q  +  A  +  D +  + IH AA F H  IV YLI +G D++ +D+   +PL+ AA R 
Sbjct: 177 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRT 236

Query: 339 -GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                   L+     + L D   +N  LH  V+ G
Sbjct: 237 HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 271



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 19/203 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 111 LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 162

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G  HT+       KG   ++
Sbjct: 163 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFG--HTSIVAYLIAKGQ-DVD 219

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 220 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 278

Query: 520 LHSVHSHLLDQIDKDGNTSLHLA 542
           L    ++ +D  +  G ++L LA
Sbjct: 279 LLEAGAN-VDAQNIKGESALDLA 300



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 14/184 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 117 DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 176

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEA 189
              KY +  ++  G   G + +H AA   H  + A ++    D +      NG  P+  A
Sbjct: 177 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD--QNGMTPLMWA 232

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A    S      L        T    ++L D    N  LH AV  G+   + L L +GA 
Sbjct: 233 AYRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 285

Query: 249 ISTQ 252
           +  Q
Sbjct: 286 VDAQ 289



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 32/161 (19%), Positives = 74/161 (45%), Gaps = 6/161 (3%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGR-GRTAAHQASARNNTNILHFINNY 69
           K N++    AA +  +D  ++ Y+S+ + +    G    T  H A+ + + +++  +  Y
Sbjct: 123 KENVTLLHWAAINNRID-LVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 181

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT-ELNKVSV 128
             D +  D  G + +H+A +      + YL+ +  +  ++++    P+  A    + V  
Sbjct: 182 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 241

Query: 129 LQVFAKYKSLFNVNQGGE-HGRTALHFAAIHDHDLCAKILI 168
            ++   +    +VN G + H  TALH+A +  +     +L+
Sbjct: 242 TRLLLTFN--VSVNLGDKYHKNTALHWAVLAGNTTVISLLL 280



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 43/208 (20%), Positives = 81/208 (38%), Gaps = 14/208 (6%)

Query: 139 FNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTI 198
           ++V Q  +   T LH+AAI++     K  I+      +   +    P+H A +      +
Sbjct: 116 YDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV 175

Query: 199 EVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLST 258
              +++G           SL D EG   +H A   G    V   +  G  +     +  T
Sbjct: 176 VQLMKYGADP--------SLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 227

Query: 259 PVHLACAQ-GALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           P+  A  +  ++D  +L+ T                K T +H A +  +  +++ L+  G
Sbjct: 228 PLMWAAYRTHSVDPTRLLLTFNVSVN----LGDKYHKNTALHWAVLAGNTTVISLLLEAG 283

Query: 318 SDINPLDKERRSPLLLAASRAG-WRTVH 344
           ++++  + +  S L LA  R   W   H
Sbjct: 284 ANVDAQNIKGESALDLAKQRKNVWMINH 311


>EF041819-1|ABL09300.1|  782|Homo sapiens several ankyrin repeat
           protein transcript variant 2 protein.
          Length = 782

 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 83/317 (26%), Positives = 133/317 (41%), Gaps = 34/317 (10%)

Query: 147 HGRTALHFAAIHDHDL-CAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           H  T LH+AA H   L C   L+    A+       G+   H AA       ++  +  G
Sbjct: 324 HKFTPLHWAA-HSGSLECLHWLLWH-GADITHVTTRGWTASHIAAIRGQDACVQALIMNG 381

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACA 265
                     ++  D+ G  PLH A   G    +++ LRSG    T + +   PVH A  
Sbjct: 382 AN--------LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGDPSVTDKREWR-PVHYAAF 432

Query: 266 QGALDIVKLMFTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
            G L  ++L+       K  C +   D     P+H AAM  H     +L++  S    + 
Sbjct: 433 HGRLGCLQLLV------KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 486

Query: 325 K---ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL----HLVVMNGGRLEDF 377
           K   +    +L  A R   + +   I+ GA+ + KD+  +  L    H+    G      
Sbjct: 487 KAFNDNGENVLDLAQRFFKQNILQFIQ-GAEYEGKDLEDQETLAFPGHVAAFKGD----- 540

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
               K   E  ++ + NE+ + G +P+H A+ +GHI  L+ LI++GA  N+ N   E P 
Sbjct: 541 LGMLKKLVEDGVINI-NERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPS 599

Query: 438 HFAARYGRFHTACQLLD 454
             A R+     A +LL+
Sbjct: 600 DVAKRFAHL-AAVKLLE 615



 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 78/307 (25%), Positives = 124/307 (40%), Gaps = 14/307 (4%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A H G ++ +   L  GA I+       T  H+A  +G    V+ +         A
Sbjct: 328 PLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM-----NGA 382

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            LT+ D +  TP+H AA   H   +  ++  G D +  DK    P+  AA       +  
Sbjct: 383 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSG-DPSVTDKREWRPVHYAAFHGRLGCLQL 441

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLH 405
           L++ G  I+  D N    +HL  M G  L  F          S  Q+L   ++ G + L 
Sbjct: 442 LVKWGCSIEDVDYNGNLPVHLAAMEG-HLHCFKFLVSRM--SSATQVLKAFNDNGENVLD 498

Query: 406 YASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS--DKGTFIIN 463
            A R      L+ +   GA    K+  ++  L F      F     +L    + G   IN
Sbjct: 499 LAQRFFKQNILQFI--QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININ 556

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHS 522
           E    G TP+H A+ +GH   +  L+  GA  +  +  G  P  +A    +   ++LL  
Sbjct: 557 ERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 616

Query: 523 VHSHLLD 529
           +  + +D
Sbjct: 617 LQKYDID 623



 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 70/285 (24%), Positives = 129/285 (45%), Gaps = 15/285 (5%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           RG TA+H A+ R     +  +     +L A+D+ G TPLH+A  +     ++ +L+   +
Sbjct: 357 RGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSG-D 415

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            SV +++   P+H A    ++  LQ+  K+    ++     +G   +H AA+  H  C K
Sbjct: 416 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGC--SIEDVDYNGNLPVHLAAMEGHLHCFK 473

Query: 166 ILITDLDAEWK--KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEG 223
            L++ + +  +  K  N+    + + A+    + I  F+Q  E  G   E   +L     
Sbjct: 474 FLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETL----- 528

Query: 224 NVPLHSAVHGGDIKAVELCLRSGA-KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
             P H A   GD+  ++  +  G   I+ +  + STP+H A  QG ++ ++ +  M    
Sbjct: 529 AFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADS 588

Query: 283 ---KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD 324
                A     DV K    H AA+    E+  Y I++ ++I+  D
Sbjct: 589 NITNKAGERPSDVAKRF-AHLAAVKLLEELQKYDIDDENEIDEND 632



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 47/155 (30%), Positives = 70/155 (45%), Gaps = 4/155 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PLH+A+  G +  L  L+  GA I        +  H AA  G+   AC       G  +
Sbjct: 327 TPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQ--DACVQALIMNGANL 384

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLH 521
             + D  G TPLH+A+  GH+  + ++L  G     D     P+H AA  G    ++LL 
Sbjct: 385 TAQDD-RGCTPLHLAATHGHSFTLQIMLRSGDPSVTDKREWRPVHYAAFHGRLGCLQLLV 443

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
                + D +D +GN  +HLA ME        L+S
Sbjct: 444 KWGCSIED-VDYNGNLPVHLAAMEGHLHCFKFLVS 477



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 67/286 (23%), Positives = 111/286 (38%), Gaps = 13/286 (4%)

Query: 285 ACLTSCDV-QKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTV 343
           A +   DV  K TP+H AA     E +++L+  G+DI  +     +   +AA R     V
Sbjct: 315 ASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACV 374

Query: 344 HTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSP 403
             LI  GA++  +D      LHL   +G     F                +  D     P
Sbjct: 375 QALIMNGANLTAQDDRGCTPLHLAATHG---HSFTLQIMLRSGDP-----SVTDKREWRP 426

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLD-SDKGTFII 462
           +HYA+  G +  L+ L++ G  I   + N   P+H AA  G  H    L+      T ++
Sbjct: 427 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 486

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLN---RGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
              +  G   L +A R     ++  +      G  L        P H+AA  G    ++ 
Sbjct: 487 KAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKK 546

Query: 520 LHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           L       +++   +G+T +H A  +     +  L+ MG   +  N
Sbjct: 547 LVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 592



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 72/356 (20%), Positives = 137/356 (38%), Gaps = 22/356 (6%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           KV+      A  +G+V     + +   S   +      T  H A+   +   LH++  + 
Sbjct: 289 KVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHG 348

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+      G T  H+A        ++ L+      +  +++   P+H+A        LQ
Sbjct: 349 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQ 408

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           +  +     +V    E     +H+AA H    C ++L+       +    NG  P+H AA
Sbjct: 409 IMLRSGDP-SVTDKREW--RPVHYAAFHGRLGCLQLLV-KWGCSIEDVDYNGNLPVHLAA 464

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSA---VHGGDIKAVELCLRSGA 247
                   +  +     R  +  Q++  +++ G   L  A        ++ ++     G 
Sbjct: 465 MEGHLHCFKFLV----SRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGK 520

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHP 307
            +  Q+  L+ P H+A  +G L ++K +     ++    +        TP+H AA   H 
Sbjct: 521 DLEDQE-TLAFPGHVAAFKGDLGMLKKLV----EDGVININERADNGSTPMHKAAGQGHI 575

Query: 308 EIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH-TLIRLGADIQLKDINSRN 362
           E + +LI  G+D N  +K    P     S    R  H   ++L  ++Q  DI+  N
Sbjct: 576 ECLQWLIKMGADSNITNKAGERP-----SDVAKRFAHLAAVKLLEELQKYDIDDEN 626


>AL590402-2|CAH74024.1|  903|Homo sapiens HECT domain and ankyrin
           repeat containing, E3 ubiquitin protein ligase 1
           protein.
          Length = 903

 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 23/230 (10%)

Query: 306 HPEIVNYLINEGSDIN-PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           H  +   L N   D+N    + +RS L +AA+      +  L++ GA+   +DI+    L
Sbjct: 43  HRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL 102

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           HL   NG +           C   LL+    +N  +N G + +H+ +  G    L +L++
Sbjct: 103 HLAARNGQK----------KCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQ 152

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
             + +++++   ++ LH A       T   LLDS      IN  +  G TPL+ A   G 
Sbjct: 153 HVSDVDVEDAMGQTALHVAC------TVQCLLDSGAD---INRPNVSGATPLYFACSHGQ 203

Query: 482 TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
                +LL RGA    D NG  PL L    GY +T E+L   H  L   I
Sbjct: 204 RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTI 253



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 11/147 (7%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A + G ++ + L L+ GA  + Q     TP+HLA   G    +  +      E  A 
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLL-----EYSAD 123

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           +  C+ + +T IH  A+    E+++ L+   SD++  D   ++ L +A       TV  L
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVAC------TVQCL 177

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  GADI   +++    L+    +G R
Sbjct: 178 LDSGADINRPNVSGATPLYFACSHGQR 204



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 11/215 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           +V  S    AA  G+V+  + L L + +    +D  G T  H A+       +  +  Y+
Sbjct: 63  RVKRSLLHIAANCGSVECLV-LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 121

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+N  +N G T +H    N   + +  L+Q   +  V +   Q  +H+A          
Sbjct: 122 ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVA--------CT 173

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V     S  ++N+    G T L+FA  H     A+IL+  L      P  NG  P+    
Sbjct: 174 VQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL--LRGAKYLPDKNGVTPLDLCV 231

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +     T EV +Q+  +   T  QM    D   N+
Sbjct: 232 QGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENM 266



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 50/198 (25%), Positives = 89/198 (44%), Gaps = 21/198 (10%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K + +H AA     E +  L+ +G++ N  D    +PL LAA     + +  L+   AD+
Sbjct: 65  KRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADV 124

Query: 354 QLKDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
            + +      +H + +NG    L D      D         ++ +D  G + LH A    
Sbjct: 125 NICNNEGLTAIHWLAVNGRTELLHDLVQHVSD---------VDVEDAMGQTALHVAC--- 172

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
              +++ L+  GA IN  N +  +PL+FA  +G+  TA Q+L      ++    D  G+T
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTA-QILLLRGAKYL---PDKNGVT 225

Query: 472 PLHIASREGHTRVVHLLL 489
           PL +  + G+     +L+
Sbjct: 226 PLDLCVQGGYGETCEVLI 243



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 18/197 (9%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   +   L  +     + N +D +G TPLH+A  N     +  LL+   + +
Sbjct: 66  RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
           + N +    IH      +  +L    ++ S  +V+     G+TALH A       C    
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVS--DVDVEDAMGQTALHVA-------CTVQC 176

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           + D  A+  +P  +G  P++ A  +    T ++ L  G +          L D  G  PL
Sbjct: 177 LLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAK---------YLPDKNGVTPL 227

Query: 228 HSAVHGGDIKAVELCLR 244
              V GG  +  E+ ++
Sbjct: 228 DLCVQGGYGETCEVLIQ 244



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 38/194 (19%), Positives = 82/194 (42%), Gaps = 20/194 (10%)

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G+++ + L+        +  ++ C     TP+H AA     + ++ L+   +D
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGC-----TPLHLAARNGQKKCMSKLLEYSAD 123

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           +N  + E  + +   A       +H L++  +D+ ++D   +  LH+             
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHV------------- 170

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
           +C   C       +N  + +G +PL++A   G  R    ++ L     L + N  +PL  
Sbjct: 171 ACTVQCLLDSGADINRPNVSGATPLYFACSHGQ-RDTAQILLLRGAKYLPDKNGVTPLDL 229

Query: 440 AARYGRFHTACQLL 453
             + G +   C++L
Sbjct: 230 CVQ-GGYGETCEVL 242



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 21/161 (13%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEW 175
           +H+A     V  L +  K  +  N N     G T LH AA +    C +K+L    D   
Sbjct: 69  LHIAANCGSVECLVLLLKKGA--NPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126

Query: 176 KKPCNN-GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGG 234
              CNN G   IH  A N  +  +   +Q            + + D  G   LH A    
Sbjct: 127 ---CNNEGLTAIHWLAVNGRTELLHDLVQHVSD--------VDVEDAMGQTALHVAC--- 172

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
               V+  L SGA I+      +TP++ AC+ G  D  +++
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 210


>AL513472-2|CAH71890.1|  903|Homo sapiens HECT domain and ankyrin
           repeat containing, E3 ubiquitin protein ligase 1
           protein.
          Length = 903

 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 23/230 (10%)

Query: 306 HPEIVNYLINEGSDIN-PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           H  +   L N   D+N    + +RS L +AA+      +  L++ GA+   +DI+    L
Sbjct: 43  HRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL 102

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           HL   NG +           C   LL+    +N  +N G + +H+ +  G    L +L++
Sbjct: 103 HLAARNGQK----------KCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQ 152

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
             + +++++   ++ LH A       T   LLDS      IN  +  G TPL+ A   G 
Sbjct: 153 HVSDVDVEDAMGQTALHVAC------TVQCLLDSGAD---INRPNVSGATPLYFACSHGQ 203

Query: 482 TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
                +LL RGA    D NG  PL L    GY +T E+L   H  L   I
Sbjct: 204 RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTI 253



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 11/147 (7%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A + G ++ + L L+ GA  + Q     TP+HLA   G    +  +      E  A 
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLL-----EYSAD 123

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           +  C+ + +T IH  A+    E+++ L+   SD++  D   ++ L +A       TV  L
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVAC------TVQCL 177

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  GADI   +++    L+    +G R
Sbjct: 178 LDSGADINRPNVSGATPLYFACSHGQR 204



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 11/215 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           +V  S    AA  G+V+  + L L + +    +D  G T  H A+       +  +  Y+
Sbjct: 63  RVKRSLLHIAANCGSVECLV-LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 121

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+N  +N G T +H    N   + +  L+Q   +  V +   Q  +H+A          
Sbjct: 122 ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVA--------CT 173

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V     S  ++N+    G T L+FA  H     A+IL+  L      P  NG  P+    
Sbjct: 174 VQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL--LRGAKYLPDKNGVTPLDLCV 231

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +     T EV +Q+  +   T  QM    D   N+
Sbjct: 232 QGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENM 266



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 50/198 (25%), Positives = 89/198 (44%), Gaps = 21/198 (10%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K + +H AA     E +  L+ +G++ N  D    +PL LAA     + +  L+   AD+
Sbjct: 65  KRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADV 124

Query: 354 QLKDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
            + +      +H + +NG    L D      D         ++ +D  G + LH A    
Sbjct: 125 NICNNEGLTAIHWLAVNGRTELLHDLVQHVSD---------VDVEDAMGQTALHVAC--- 172

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
              +++ L+  GA IN  N +  +PL+FA  +G+  TA Q+L      ++    D  G+T
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTA-QILLLRGAKYL---PDKNGVT 225

Query: 472 PLHIASREGHTRVVHLLL 489
           PL +  + G+     +L+
Sbjct: 226 PLDLCVQGGYGETCEVLI 243



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 18/197 (9%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   +   L  +     + N +D +G TPLH+A  N     +  LL+   + +
Sbjct: 66  RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
           + N +    IH      +  +L    ++ S  +V+     G+TALH A       C    
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVS--DVDVEDAMGQTALHVA-------CTVQC 176

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           + D  A+  +P  +G  P++ A  +    T ++ L  G +          L D  G  PL
Sbjct: 177 LLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAK---------YLPDKNGVTPL 227

Query: 228 HSAVHGGDIKAVELCLR 244
              V GG  +  E+ ++
Sbjct: 228 DLCVQGGYGETCEVLIQ 244



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 38/194 (19%), Positives = 82/194 (42%), Gaps = 20/194 (10%)

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G+++ + L+        +  ++ C     TP+H AA     + ++ L+   +D
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGC-----TPLHLAARNGQKKCMSKLLEYSAD 123

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           +N  + E  + +   A       +H L++  +D+ ++D   +  LH+             
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHV------------- 170

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
           +C   C       +N  + +G +PL++A   G  R    ++ L     L + N  +PL  
Sbjct: 171 ACTVQCLLDSGADINRPNVSGATPLYFACSHGQ-RDTAQILLLRGAKYLPDKNGVTPLDL 229

Query: 440 AARYGRFHTACQLL 453
             + G +   C++L
Sbjct: 230 CVQ-GGYGETCEVL 242



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 21/161 (13%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEW 175
           +H+A     V  L +  K  +  N N     G T LH AA +    C +K+L    D   
Sbjct: 69  LHIAANCGSVECLVLLLKKGA--NPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126

Query: 176 KKPCNN-GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGG 234
              CNN G   IH  A N  +  +   +Q            + + D  G   LH A    
Sbjct: 127 ---CNNEGLTAIHWLAVNGRTELLHDLVQHVSD--------VDVEDAMGQTALHVAC--- 172

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
               V+  L SGA I+      +TP++ AC+ G  D  +++
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 210


>AL357315-1|CAI16815.1|  903|Homo sapiens HECT domain and ankyrin
           repeat containing, E3 ubiquitin protein ligase 1
           protein.
          Length = 903

 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 23/230 (10%)

Query: 306 HPEIVNYLINEGSDIN-PLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
           H  +   L N   D+N    + +RS L +AA+      +  L++ GA+   +DI+    L
Sbjct: 43  HRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL 102

Query: 365 HLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSPLHYASREGHIRSLENLIR 421
           HL   NG +           C   LL+    +N  +N G + +H+ +  G    L +L++
Sbjct: 103 HLAARNGQK----------KCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQ 152

Query: 422 LGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGH 481
             + +++++   ++ LH A       T   LLDS      IN  +  G TPL+ A   G 
Sbjct: 153 HVSDVDVEDAMGQTALHVAC------TVQCLLDSGAD---INRPNVSGATPLYFACSHGQ 203

Query: 482 TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQI 531
                +LL RGA    D NG  PL L    GY +T E+L   H  L   I
Sbjct: 204 RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTI 253



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 11/147 (7%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHAC 286
           LH A + G ++ + L L+ GA  + Q     TP+HLA   G    +  +      E  A 
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLL-----EYSAD 123

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTL 346
           +  C+ + +T IH  A+    E+++ L+   SD++  D   ++ L +A       TV  L
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVAC------TVQCL 177

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGR 373
           +  GADI   +++    L+    +G R
Sbjct: 178 LDSGADINRPNVSGATPLYFACSHGQR 204



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 11/215 (5%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYA 70
           +V  S    AA  G+V+  + L L + +    +D  G T  H A+       +  +  Y+
Sbjct: 63  RVKRSLLHIAANCGSVECLV-LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 121

Query: 71  GDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQ 130
            D+N  +N G T +H    N   + +  L+Q   +  V +   Q  +H+A          
Sbjct: 122 ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVA--------CT 173

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
           V     S  ++N+    G T L+FA  H     A+IL+  L      P  NG  P+    
Sbjct: 174 VQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL--LRGAKYLPDKNGVTPLDLCV 231

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNV 225
           +     T EV +Q+  +   T  QM    D   N+
Sbjct: 232 QGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENM 266



 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 50/198 (25%), Positives = 89/198 (44%), Gaps = 21/198 (10%)

Query: 294 KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADI 353
           K + +H AA     E +  L+ +G++ N  D    +PL LAA     + +  L+   AD+
Sbjct: 65  KRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADV 124

Query: 354 QLKDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREG 411
            + +      +H + +NG    L D      D         ++ +D  G + LH A    
Sbjct: 125 NICNNEGLTAIHWLAVNGRTELLHDLVQHVSD---------VDVEDAMGQTALHVAC--- 172

Query: 412 HIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLT 471
              +++ L+  GA IN  N +  +PL+FA  +G+  TA Q+L      ++    D  G+T
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTA-QILLLRGAKYL---PDKNGVT 225

Query: 472 PLHIASREGHTRVVHLLL 489
           PL +  + G+     +L+
Sbjct: 226 PLDLCVQGGYGETCEVLI 243



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 18/197 (9%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           R+  H A+   +   L  +     + N +D +G TPLH+A  N     +  LL+   + +
Sbjct: 66  RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
           + N +    IH      +  +L    ++ S  +V+     G+TALH A       C    
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVS--DVDVEDAMGQTALHVA-------CTVQC 176

Query: 168 ITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPL 227
           + D  A+  +P  +G  P++ A  +    T ++ L  G +          L D  G  PL
Sbjct: 177 LLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAK---------YLPDKNGVTPL 227

Query: 228 HSAVHGGDIKAVELCLR 244
              V GG  +  E+ ++
Sbjct: 228 DLCVQGGYGETCEVLIQ 244



 Score = 45.6 bits (103), Expect = 0.001
 Identities = 38/194 (19%), Positives = 82/194 (42%), Gaps = 20/194 (10%)

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           +H+A   G+++ + L+        +  ++ C     TP+H AA     + ++ L+   +D
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGC-----TPLHLAARNGQKKCMSKLLEYSAD 123

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAA 379
           +N  + E  + +   A       +H L++  +D+ ++D   +  LH+             
Sbjct: 124 VNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHV------------- 170

Query: 380 SCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHF 439
           +C   C       +N  + +G +PL++A   G  R    ++ L     L + N  +PL  
Sbjct: 171 ACTVQCLLDSGADINRPNVSGATPLYFACSHGQ-RDTAQILLLRGAKYLPDKNGVTPLDL 229

Query: 440 AARYGRFHTACQLL 453
             + G +   C++L
Sbjct: 230 CVQ-GGYGETCEVL 242



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 21/161 (13%)

Query: 117 IHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEW 175
           +H+A     V  L +  K  +  N N     G T LH AA +    C +K+L    D   
Sbjct: 69  LHIAANCGSVECLVLLLKKGA--NPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126

Query: 176 KKPCNN-GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGG 234
              CNN G   IH  A N  +  +   +Q            + + D  G   LH A    
Sbjct: 127 ---CNNEGLTAIHWLAVNGRTELLHDLVQHVSD--------VDVEDAMGQTALHVAC--- 172

Query: 235 DIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
               V+  L SGA I+      +TP++ AC+ G  D  +++
Sbjct: 173 ---TVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 210


>AK001283-1|BAA91599.1|  445|Homo sapiens protein ( Homo sapiens
           cDNA FLJ10421 fis, clone NT2RP1000202, weakly similar to
           ANKYRIN. ).
          Length = 445

 Score = 76.6 bits (180), Expect = 5e-13
 Identities = 60/193 (31%), Positives = 92/193 (47%), Gaps = 12/193 (6%)

Query: 331 LLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL 390
           L LAAS+  W+ V  L+  GAD     +     L   V NG    D       H      
Sbjct: 10  LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQI--DVLRLLLQHGAN--- 64

Query: 391 QLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC 450
            +       G + LH AS + +   ++ L+R GA    +++   +PL  AA+YG+  +  
Sbjct: 65  -VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123

Query: 451 QLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA---LLHRDHNGRNPLHL 507
            L+ S      +N    +  TPL IA++EGHT+ V LLL+ GA   L   + + + P+H 
Sbjct: 124 ILISSGAN---VNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180

Query: 508 AAMSGYTKTIELL 520
           AA  G+TK ++LL
Sbjct: 181 AAQMGHTKILDLL 193



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 59/225 (26%), Positives = 104/225 (46%), Gaps = 10/225 (4%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H AA   H +IV  L+  G+D N    E  +PL  A        +  L++ GA++    
Sbjct: 10  LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANVN--- 66

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
             S ++     ++    ++ A   K    K   +    +D+ G +PL  A++ G + SL 
Sbjct: 67  -GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC--QDDFGITPLFVAAQYGKLESLS 123

Query: 418 NLIRLGACINLKNNNNESPLHFAARYGRFHTAC-QLLDSDKGTFIINESDGEGLTPLHIA 476
            LI  GA +N +  +  +PL  AA+ G  HT C +LL S      +  ++     P+H A
Sbjct: 124 ILISSGANVNCQALDKATPLFIAAQEG--HTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181

Query: 477 SREGHTRVVHLLLN-RGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
           ++ GHT+++ LL+           N  +P++ A   G+   +E+L
Sbjct: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 226



 Score = 59.7 bits (138), Expect = 6e-08
 Identities = 68/249 (27%), Positives = 108/249 (43%), Gaps = 31/249 (12%)

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+  +H AA     + +++ L+ G     T          E   PL SAV  G I  + L
Sbjct: 6   GFCALHLAASQGHWKIVQILLEAGADPNATTL--------EETTPLFSAVENGQIDVLRL 57

Query: 242 CLRSGAKISTQQHDLS--TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIH 299
            L+ GA ++   H +     +H A  Q   +I+KL+       K A     D   +TP+ 
Sbjct: 58  LLQHGANVNGS-HSMCGWNSLHQASFQENAEIIKLLL-----RKGANKECQDDFGITPLF 111

Query: 300 CAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDIN 359
            AA +   E ++ LI+ G+++N    ++ +PL +AA     + V  L+  GAD  L   N
Sbjct: 112 VAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY-CN 170

Query: 360 SRNVLHLVVMNGGRLEDFAASCKDHCE--KSLLQLLNEKDNTG---CSPLHYASREGHIR 414
                     +  +L   AA+   H +    L+ L N   +TG    SP++ A   GH  
Sbjct: 171 E---------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHED 221

Query: 415 SLENLIRLG 423
            LE L+R G
Sbjct: 222 CLEILLRNG 230



 Score = 55.6 bits (128), Expect = 1e-06
 Identities = 56/237 (23%), Positives = 104/237 (43%), Gaps = 20/237 (8%)

Query: 222 EGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPK 281
           EG   LH A   G  K V++ L +GA  +    + +TP+  A   G +D+++L+      
Sbjct: 5   EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLL-QHGA 63

Query: 282 EKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWR 341
             +   + C       +H A+  ++ EI+  L+ +G++    D    +PL +AA      
Sbjct: 64  NVNGSHSMCG---WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120

Query: 342 TVHTLIRLGADIQLKDINSRNVLHLVVMNGGR--LEDFAASCKD---HCEKSLLQLLNEK 396
           ++  LI  GA++  + ++    L +    G    +E   +S  D   +C +   QL    
Sbjct: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL---- 176

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLL 453
                 P+H A++ GH + L+ LI L         N  SP+ ++A +G      ++L
Sbjct: 177 ------PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV-YSAVFGGHEDCLEIL 226



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 68/284 (23%), Positives = 116/284 (40%), Gaps = 22/284 (7%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G  A H A+++ +  I+  +     D NA      TPL  AVEN  +D +  LLQ     
Sbjct: 6   GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANV 65

Query: 107 SVLNEKC-QAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
           +  +  C    +H A+      ++++  +  +  N     + G T L  AA +       
Sbjct: 66  NGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKECQDDFGITPLFVAAQYGKLESLS 123

Query: 166 ILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGN- 224
           ILI+   A       +   P+  AA+   ++ +E+ L  G            LY NE + 
Sbjct: 124 ILISS-GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP--------DLYCNEDSW 174

Query: 225 -VPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMF-TMQPKE 282
            +P+H+A   G  K ++L +    +      +  +PV+ A   G  D ++++       +
Sbjct: 175 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPE---IVNYLINEGSDINPL 323
             ACL        +P+ C A     E   IVN L+  G+ IN L
Sbjct: 235 AQACLV---FGFSSPV-CMAFQKDCEFFGIVNILLKYGAQINEL 274



 Score = 41.1 bits (92), Expect = 0.023
 Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 1/92 (1%)

Query: 468 EGLTPLHIASREGHTRVVHLLLNRGALLHRDH-NGRNPLHLAAMSGYTKTIELLHSVHSH 526
           EG   LH+A+ +GH ++V +LL  GA  +        PL  A  +G    + LL    ++
Sbjct: 5   EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGAN 64

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMG 558
           +       G  SLH A+ +     I LLL  G
Sbjct: 65  VNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 96



 Score = 40.7 bits (91), Expect = 0.030
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNN-NESPLHFAARYGRFHTACQLLDSDKGTF 460
           +PL  A   G I  L  L++ GA +N  ++    + LH A+          LL       
Sbjct: 41  TPLFSAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 100

Query: 461 IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIEL 519
                D  G+TPL +A++ G    + +L++ GA ++ +  +   PL +AA  G+TK +EL
Sbjct: 101 C---QDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL 157

Query: 520 LHS 522
           L S
Sbjct: 158 LLS 160


>AB209433-1|BAD92670.1| 1031|Homo sapiens HLA-B associated
           transcript 8 BAT8 isoform a variant protein.
          Length = 1031

 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 72/244 (29%), Positives = 114/244 (46%), Gaps = 25/244 (10%)

Query: 260 VHLACAQGALDIVKLMF--TMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           ++L+  QG L  V LM    + P        S    K TP+H AA     EI + L+  G
Sbjct: 468 LYLSVKQGELQKVILMLLDNLDPN-----FQSDQQSKRTPLHAAAQKGSVEICHVLLQAG 522

Query: 318 SDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDF 377
           ++IN +DK++R+PL+ A           +++ G  +  K+ +    LH      G LE  
Sbjct: 523 ANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAA-KIGNLEMV 581

Query: 378 AASCKDHCEKSLLQL-LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNES- 435
           +         S  Q+ +N +D+ G +P+ +A+   HI  +  L+  GA + L +N +E  
Sbjct: 582 SLLL------STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERL 635

Query: 436 ------PLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
                  LH+A+  G    A  LL++      +N     G TPLHIA+RE +   V L L
Sbjct: 636 VEEENICLHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCVLLFL 692

Query: 490 NRGA 493
           +RGA
Sbjct: 693 SRGA 696



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 49/183 (26%), Positives = 77/183 (42%), Gaps = 11/183 (6%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N  D    +PL  A    H+     +++ G C+  K  +  + LH AA+ G       L
Sbjct: 525 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 584

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL------- 505
           L +  G   +N  D  G TP+  A+   H  V+ +LL RGA +    N    L       
Sbjct: 585 LST--GQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENIC 642

Query: 506 -HLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYN 564
            H A+ +G     E+L +    L   ++  G+T LH+A  E+    + L LS G      
Sbjct: 643 LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELR 701

Query: 565 NMD 567
           N +
Sbjct: 702 NKE 704



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 51/213 (23%), Positives = 95/213 (44%), Gaps = 10/213 (4%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH+A   G ++   + L++GA I+       TP+  A     L++ + M      ++  
Sbjct: 502 PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-----QRGG 556

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVH 344
           C+ S +    T +H AA   + E+V+ L++ G  D+N  D    +P++ AA       + 
Sbjct: 557 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 616

Query: 345 TLIRLGADIQLKDINSRNVL--HLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
            L+  GAD+ L D  S  ++    + ++       AA  +          L+  +  G +
Sbjct: 617 MLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARC--DLHAVNYHGDT 674

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNES 435
           PLH A+RE +   +   +  GA   L+N   ++
Sbjct: 675 PLHIAARESYHDCVLLFLSRGANPELRNKEGDT 707



 Score = 58.0 bits (134), Expect = 2e-07
 Identities = 49/216 (22%), Positives = 88/216 (40%), Gaps = 3/216 (1%)

Query: 62  ILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT 121
           IL  ++N   +  +   +  TPLH A +  +++    LLQ     + ++++ + P+  A 
Sbjct: 481 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 540

Query: 122 ELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNN 181
             N + V +   +      V    E G T LH AA   +     +L++    +     + 
Sbjct: 541 VNNHLEVARYMVQRGGC--VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSG 598

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ PI  AA++     I + L  G     T      L + E N+ LH A   G     E+
Sbjct: 599 GWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEE-NICLHWASFTGSAAIAEV 657

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFT 277
            L +   +    +   TP+H+A  +   D V L  +
Sbjct: 658 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS 693



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 31/122 (25%), Positives = 55/122 (45%), Gaps = 1/122 (0%)

Query: 48  RTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETS 107
           RT  H A+ + +  I H +     ++NA D    TPL  AV N  L+   Y++Q+     
Sbjct: 500 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 559

Query: 108 VLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKIL 167
              E     +H A ++  + ++ +      + +VN     G T + +AA H H    ++L
Sbjct: 560 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRML 618

Query: 168 IT 169
           +T
Sbjct: 619 LT 620



 Score = 40.3 bits (90), Expect = 0.040
 Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 12/132 (9%)

Query: 47  GRTAAHQASARNNTNILHFINNYAG-DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           G T  H A+   N  ++  + +    D+NA+D+ G TP+  A E++ ++ I  LL +  +
Sbjct: 565 GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGAD 624

Query: 106 TSV-------LNEKCQAPIHMATELNKVSVLQVFAKYK-SLFNVNQGGEHGRTALHFAAI 157
            ++       L E+    +H A+     ++ +V    +  L  VN    HG T LH AA 
Sbjct: 625 VTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDLHAVNY---HGDTPLHIAAR 681

Query: 158 HDHDLCAKILIT 169
             +  C  + ++
Sbjct: 682 ESYHDCVLLFLS 693


>DQ508934-1|ABF57994.1|  591|Homo sapiens SARP3 protein.
          Length = 591

 Score = 74.9 bits (176), Expect = 2e-12
 Identities = 67/230 (29%), Positives = 105/230 (45%), Gaps = 24/230 (10%)

Query: 290 CDVQKMT--PIHCAAMFDHPEIVNYLINEGSDINPLDKERR-SPLLLAASRAGWRTVHTL 346
           C  +KM    IH A      + ++ ++  G+ IN LD   + +PL  AA       +H L
Sbjct: 339 CSRKKMHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWL 398

Query: 347 IRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQL---LNEKDNTGCSP 403
           +  GADI           H+  + G          +D C ++L+     L  +D+ GC+P
Sbjct: 399 LWHGADITHVTTRDWTASHIAAIRG----------QDACVQALIMNGANLTAQDDRGCTP 448

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH A+  GH  +L+ ++R G   ++ +     P+H+AA +GR     QLL   K    I 
Sbjct: 449 LHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRL-GCLQLL--VKWGCSIE 505

Query: 464 ESDGEGLTPLHIASREGHTRVVHLLLNR-----GALLHRDHNGRNPLHLA 508
           + D  G  P+H+A+ EGH      L++R       L   + NG N L LA
Sbjct: 506 DVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLA 555



 Score = 64.9 bits (151), Expect = 2e-09
 Identities = 61/223 (27%), Positives = 97/223 (43%), Gaps = 19/223 (8%)

Query: 227 LHSAVHGGDIKAVELCLRSGAKISTQQ--HDLSTPVHLACAQGALDIVKLMFTMQPKEKH 284
           +H AV  GD+K +   +  GA I+     H   TP+H A   G+L+ +  +         
Sbjct: 349 IHDAVRAGDVKQLSEIVVRGASINELDVLHKF-TPLHWAAHSGSLECLHWLLW-----HG 402

Query: 285 ACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVH 344
           A +T    +  T  H AA+      V  LI  G+++   D    +PL LAA+     T+ 
Sbjct: 403 ADITHVTTRDWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQ 462

Query: 345 TLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
            ++R G D  + D      +H    + GRL       K  C       + + D  G  P+
Sbjct: 463 IMLRSGVDPSVTDKREWRPVHYAAFH-GRLGCLQLLVKWGCS------IEDVDYNGNLPV 515

Query: 405 HYASREGHIRSLENLI-RLGACIN-LK--NNNNESPLHFAARY 443
           H A+ EGH+   + L+ R+ +    LK  N+N E+ L  A R+
Sbjct: 516 HLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRF 558



 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 5/156 (3%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +PLH+A+  G +  L  L+  GA I      + +  H AA  G+   AC       G  +
Sbjct: 381 TPLHWAAHSGSLECLHWLLWHGADITHVTTRDWTASHIAAIRGQ--DACVQALIMNGANL 438

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL 520
             + D  G TPLH+A+  GH+  + ++L  G      D     P+H AA  G    ++LL
Sbjct: 439 TAQDD-RGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 497

Query: 521 HSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLS 556
                 + D +D +GN  +HLA ME        L+S
Sbjct: 498 VKWGCSIED-VDYNGNLPVHLAAMEGHLHCFKFLVS 532



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 48/161 (29%), Positives = 74/161 (45%), Gaps = 8/161 (4%)

Query: 404 LHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           +H A R G ++ L  ++  GA IN L   +  +PLH+AA  G       LL        +
Sbjct: 349 IHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHV 408

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGA-LLHRDHNGRNPLHLAAMSGYTKTIELLH 521
              D    T  HIA+  G    V  L+  GA L  +D  G  PLHLAA  G++ T++++ 
Sbjct: 409 TTRDW---TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM- 464

Query: 522 SVHSHLLDQI-DKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            + S +   + DK     +H A    +   + LL+  GC +
Sbjct: 465 -LRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSI 504



 Score = 58.4 bits (135), Expect = 1e-07
 Identities = 42/168 (25%), Positives = 80/168 (47%), Gaps = 5/168 (2%)

Query: 46  RGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           R  TA+H A+ R     +  +     +L A+D+ G TPLH+A  +     ++ +L+  V+
Sbjct: 411 RDWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVD 470

Query: 106 TSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAK 165
            SV +++   P+H A    ++  LQ+  K+    ++     +G   +H AA+  H  C K
Sbjct: 471 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGC--SIEDVDYNGNLPVHLAAMEGHLHCFK 528

Query: 166 ILITDLDAEWK--KPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCT 211
            L++ + +  +  K  N+    + + A+    + I  F+Q G  R  T
Sbjct: 529 FLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQ-GSPRPAT 575



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 41/146 (28%), Positives = 62/146 (42%), Gaps = 5/146 (3%)

Query: 226 PLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHA 285
           PLH A H G ++ +   L  GA I+       T  H+A  +G    V+ +         A
Sbjct: 382 PLHWAAHSGSLECLHWLLWHGADITHVTTRDWTASHIAAIRGQDACVQALIM-----NGA 436

Query: 286 CLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHT 345
            LT+ D +  TP+H AA   H   +  ++  G D +  DK    P+  AA       +  
Sbjct: 437 NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQL 496

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNG 371
           L++ G  I+  D N    +HL  M G
Sbjct: 497 LVKWGCSIEDVDYNGNLPVHLAAMEG 522



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 7/142 (4%)

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+  G    ++ LI  GA +  +++   +PLH AA +G   T   +L S     + ++
Sbjct: 417 HIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDK 476

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSV 523
            +     P+H A+  G    + LL+  G  +   D+NG  P+HLAAM G+    + L S 
Sbjct: 477 REWR---PVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 533

Query: 524 HS---HLLDQIDKDGNTSLHLA 542
            S    +L   + +G   L LA
Sbjct: 534 MSSATQVLKAFNDNGENVLDLA 555



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 7/104 (6%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           ++  D+ G  PLH A   G    +++ LRSG   S        PVH A   G L  ++L+
Sbjct: 438 LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 497

Query: 276 FTMQPKEKHAC-LTSCDVQKMTPIHCAAMFDHPEIVNYLINEGS 318
                  K  C +   D     P+H AAM  H     +L++  S
Sbjct: 498 V------KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMS 535



 Score = 33.1 bits (72), Expect = 6.0
 Identities = 28/142 (19%), Positives = 56/142 (39%), Gaps = 3/142 (2%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H A+   +   LH++  +  D+        T  H+A        ++ L+      + 
Sbjct: 381 TPLHWAAHSGSLECLHWLLWHGADITHVTTRDWTASHIAAIRGQDACVQALIMNGANLTA 440

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILI 168
            +++   P+H+A        LQ+    +S  + +   +     +H+AA H    C ++L+
Sbjct: 441 QDDRGCTPLHLAATHGHSFTLQIM--LRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV 498

Query: 169 TDLDAEWKKPCNNGYYPIHEAA 190
                  +    NG  P+H AA
Sbjct: 499 -KWGCSIEDVDYNGNLPVHLAA 519


>CR457302-1|CAG33583.1|  278|Homo sapiens ASB13 protein.
          Length = 278

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 50/181 (27%), Positives = 88/181 (48%), Gaps = 14/181 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+HEAA+   S  ++  ++ G    C  +  +     +   PLH+A   G  + V+L L 
Sbjct: 22  PVHEAAQRGESLQLQQLIESG---ACVNQVTV-----DSITPLHAASLQGQARCVQLLLA 73

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
           +GA++  +  D STP+  ACA G+++ VKL+ +   K      T+      +P+H A M 
Sbjct: 74  AGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA------SPLHEACMS 127

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
              E V  LI+ G+++   D    +PL +A +R     V  L+  GA++    ++   + 
Sbjct: 128 GSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALH 187

Query: 365 H 365
           H
Sbjct: 188 H 188



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 4/177 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +P+H A++ G    L+ LI  GAC+N    ++ +PLH A+  G+      LL +      
Sbjct: 21  TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ--- 77

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLH 521
           ++  + +G TPL  A   G    V LLL+ GA ++      +PLH A MSG ++ + LL 
Sbjct: 78  VDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLI 137

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
            V ++ L+  D    T LH+A        + +LL+ G  ++   +  +A+ +A   K
Sbjct: 138 DVGAN-LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVK 193



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 62/234 (26%), Positives = 99/234 (42%), Gaps = 23/234 (9%)

Query: 278 MQPKEKHACLTSCDVQ---KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           M+P+    C    DV    + TP+H AA       +  LI  G+ +N +  +  +PL  A
Sbjct: 1   MEPRAADGCFLG-DVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAA 59

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           + +   R V  L+  GA +  ++I+    L           D  AS    C K LL    
Sbjct: 60  SLQGQARCVQLLLAAGAQVDARNIDGSTPLC----------DACASGSIECVKLLLS-YG 108

Query: 395 EKDNT---GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            K N      SPLH A   G    +  LI +GA +   + +  +PLH A    R H  C 
Sbjct: 109 AKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVAC--AREHLDCV 166

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
            +  + G  +      E  T LH A++  +  ++ +L+  G  ++ RD+ G+ P
Sbjct: 167 KVLLNAGANVNAAKLHE--TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 56/193 (29%), Positives = 80/193 (41%), Gaps = 11/193 (5%)

Query: 328 RSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEK 387
           R+P+  AA R     +  LI  GA +    ++S   LH   + G       A C      
Sbjct: 20  RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG------QARCVQLLLA 73

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
           +  Q+ + ++  G +PL  A   G I  ++ L+  GA +N       SPLH A   G   
Sbjct: 74  AGAQV-DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGS-- 129

Query: 448 TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHL 507
           + C  L  D G  +    D    TPLH+A    H   V +LLN GA ++        LH 
Sbjct: 130 SECVRLLIDVGANL-EAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHH 188

Query: 508 AAMSGYTKTIELL 520
           AA       IE+L
Sbjct: 189 AAKVKNVDLIEML 201



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 52  HQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ--QHVETSVL 109
           H+A    ++  +  + +   +L A D    TPLHVA   E LD ++ LL    +V  + L
Sbjct: 122 HEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL 181

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKY 135
           +E     +H A ++  V ++++  ++
Sbjct: 182 HE---TALHHAAKVKNVDLIEMLIEF 204



 Score = 35.5 bits (78), Expect = 1.1
 Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 13/161 (8%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H AS +     +  +      ++A++  G+TPL  A  + +++ ++ LL        
Sbjct: 54  TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLS------- 106

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE----HGRTALHFAAIHDHDLCA 164
              K   P++ A+ L++  +       + L +V    E    H  T LH A   +H  C 
Sbjct: 107 YGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 166

Query: 165 KILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           K+L+ +  A            +H AAK  +   IE+ +++G
Sbjct: 167 KVLL-NAGAN-VNAAKLHETALHHAAKVKNVDLIEMLIEFG 205


>BC126351-1|AAI26352.1|  467|Homo sapiens ASB10 protein protein.
          Length = 467

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 69/227 (30%), Positives = 100/227 (44%), Gaps = 24/227 (10%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT-VHTLIRLGADIQ 354
           TP+H AA   H E++  L+   +  +     R +  L  A  AG    VH L+  GAD  
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA--LHEACAAGHTACVHVLLVAGADPN 175

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
           + D + +  LHL     G LE     C +   +   ++    +    +PLH A+R GH+ 
Sbjct: 176 IADQDGKRPLHLC-RGPGTLE-----CAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 229

Query: 415 SLENLIRLGACINLKNNNNESPLHFA------------ARYGRFHTACQLLDSDKGTFII 462
             + L+R GAC + +N    +PL  A            A   R    C LL S       
Sbjct: 230 LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD--A 287

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
           + +D +   PLH+A R GH  VV LLL+ G   +  D+ G  PLH A
Sbjct: 288 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 59/182 (32%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G + LH A   GH   +  L+  GA  N+ + + + PLH     G    A  LL    G 
Sbjct: 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF--GA 205

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIE 518
            +   S+ E  TPLH+A+R GH  +  LLL RGA    R+  G  PL LAA     ++I 
Sbjct: 206 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL-LAACDVRCQSIT 264

Query: 519 LLHSVHSHLL-------------DQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
              +  +  L             D  D+D    LHLA      + + LLLS  C +S N 
Sbjct: 265 DAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS--CGVSANT 322

Query: 566 MD 567
           MD
Sbjct: 323 MD 324



 Score = 60.1 bits (139), Expect = 5e-08
 Identities = 74/289 (25%), Positives = 117/289 (40%), Gaps = 25/289 (8%)

Query: 251 TQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIV 310
           T + +L+TP+H+A ++G  ++++L+   + +   A          T +H A    H   V
Sbjct: 111 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSA------PGGRTALHEACAAGHTACV 164

Query: 311 NYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ-LKDINSRNVLHLVVM 369
           + L+  G+D N  D++ + PL L            L+R GA +    +      LH+   
Sbjct: 165 HVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR 224

Query: 370 NGG-RLEDF---AASCKDHCEKSLLQLLNEKDNTGCSPL--HYASREGHIRSLENLIRLG 423
            G   L D      +C D         L    +  C  +    A+    ++    L+  G
Sbjct: 225 LGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAG 284

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR----- 478
           A  +  + + + PLH A R G  H A   L    G    N  D  G TPLH A +     
Sbjct: 285 ADADAADQDKQRPLHLACRRG--HAAVVELLLSCGV-SANTMDYGGHTPLHCALQGPAAA 341

Query: 479 --EGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
             +    VV  LLN GA+  R   G  P  L   S   +TIE+L + +S
Sbjct: 342 LAQSPEHVVRALLNHGAV--RVWPGALPKVLERWSTCPRTIEVLMNTYS 388



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 57/229 (24%), Positives = 90/229 (39%), Gaps = 19/229 (8%)

Query: 111 EKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD 170
           E+   P+H+A       VL++  + ++  +   GG   RTALH A    H  C  +L+  
Sbjct: 114 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG---RTALHEACAAGHTACVHVLLV- 169

Query: 171 LDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
             A+      +G  P+H      +    E+ L++G +     E+       E   PLH A
Sbjct: 170 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE-------EEETPLHVA 222

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC---AQGALDIVK-----LMFTMQPKE 282
              G ++  +L LR GA    +  +  TP+  AC    Q   D        L        
Sbjct: 223 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 282

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
             A   + D  K  P+H A    H  +V  L++ G   N +D    +PL
Sbjct: 283 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 331



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 34/91 (37%), Positives = 44/91 (48%), Gaps = 1/91 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           TPLH+A+  GHT V+ LLL R A       GR  LH A  +G+T  + +L  V     + 
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL-LVAGADPNI 176

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            D+DG   LHL           LLL  G R+
Sbjct: 177 ADQDGKRPLHLCRGPGTLECAELLLRFGARV 207



 Score = 49.6 bits (113), Expect = 6e-05
 Identities = 41/125 (32%), Positives = 55/125 (44%), Gaps = 5/125 (4%)

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           +PLH AA  G       LL          +S   G T LH A   GHT  VH+LL  GA 
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARP----DSAPGGRTALHEACAAGHTACVHVLLVAGAD 173

Query: 495 LH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
            +  D +G+ PLHL    G  +  ELL    + +  + +++  T LH+A          L
Sbjct: 174 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 233

Query: 554 LLSMG 558
           LL  G
Sbjct: 234 LLRRG 238



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 58/229 (25%), Positives = 93/229 (40%), Gaps = 29/229 (12%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+ +  +RL L   +R     G GRTA H+A A  +T  +H +     D N  D  
Sbjct: 123 AASRGHTE-VLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIADQD 180

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLN-EKCQAPIHMATELNKVSVLQVFAKYKSL 138
           G  PLH+      L+  E LL+        + E+ + P+H+A  L  V +  +  +  + 
Sbjct: 181 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 240

Query: 139 FNVNQGGEHGRTALHFA------AIHDHD--------LCAKILITDLDAEWKKPCNNGYY 184
            +       G T L  A      +I D +        LC+ +L    DA+      +   
Sbjct: 241 PDARNA--EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADAD--AADQDKQR 296

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           P+H A +   +  +E+ L  G           +  D  G+ PLH A+ G
Sbjct: 297 PLHLACRRGHAAVVELLLSCGVS--------ANTMDYGGHTPLHCALQG 337



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 4/112 (3%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G   LH A   G    V + L +GA  +    D   P+HL    G L+  +L+     + 
Sbjct: 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 207

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
                   + ++ TP+H AA   H E+ + L+  G+  +  + E  +PLL A
Sbjct: 208 D----GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 255



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 12/90 (13%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
           ++   L L +GA       D   P+HLAC +G   +V+L+ +           + D    
Sbjct: 274 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSC-----GVSANTMDYGGH 328

Query: 296 TPIHC------AAMFDHPE-IVNYLINEGS 318
           TP+HC      AA+   PE +V  L+N G+
Sbjct: 329 TPLHCALQGPAAALAQSPEHVVRALLNHGA 358


>AL365356-2|CAH72614.1|  278|Homo sapiens ankyrin repeat and SOCS
           box-containing 13 protein.
          Length = 278

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 50/181 (27%), Positives = 88/181 (48%), Gaps = 14/181 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+HEAA+   S  ++  ++ G    C  +  +     +   PLH+A   G  + V+L L 
Sbjct: 22  PVHEAAQRGESLQLQQLIESG---ACVNQVTV-----DSITPLHAASLQGQARCVQLLLA 73

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
           +GA++  +  D STP+  ACA G+++ VKL+ +   K      T+      +P+H A M 
Sbjct: 74  AGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA------SPLHEACMS 127

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
              E V  LI+ G+++   D    +PL +A +R     V  L+  GA++    ++   + 
Sbjct: 128 GSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALH 187

Query: 365 H 365
           H
Sbjct: 188 H 188



 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 4/177 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +P+H A++ G    L+ LI  GAC+N    ++ +PLH A+  G+      LL +      
Sbjct: 21  TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ--- 77

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLH 521
           ++  + +G TPL  A   G    V LLL+ GA ++      +PLH A MSG ++ + LL 
Sbjct: 78  VDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLI 137

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
            V ++ L+  D    T LH+A        + +LL+ G  ++   +  +A+ +A   K
Sbjct: 138 DVGAN-LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVK 193



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 62/234 (26%), Positives = 99/234 (42%), Gaps = 23/234 (9%)

Query: 278 MQPKEKHACLTSCDVQ---KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           M+P+    C    DV    + TP+H AA       +  LI  G+ +N +  +  +PL  A
Sbjct: 1   MEPRAADGCFLG-DVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAA 59

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           + +   R V  L+  GA +  ++I+    L           D  AS    C K LL    
Sbjct: 60  SLQGQARCVQLLLAAGAQVDARNIDGSTPLC----------DACASGSIECVKLLLS-YG 108

Query: 395 EKDNT---GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            K N      SPLH A   G    +  LI +GA +   + +  +PLH A    R H  C 
Sbjct: 109 AKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVAC--AREHLDCV 166

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
            +  + G  +      E  T LH A++  +  ++ +L+  G  ++ RD+ G+ P
Sbjct: 167 KVLLNAGANVNAAKLHE--TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 56/193 (29%), Positives = 80/193 (41%), Gaps = 11/193 (5%)

Query: 328 RSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEK 387
           R+P+  AA R     +  LI  GA +    ++S   LH   + G       A C      
Sbjct: 20  RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG------QARCVQLLLA 73

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
           +  Q+ + ++  G +PL  A   G I  ++ L+  GA +N       SPLH A   G   
Sbjct: 74  AGAQV-DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGS-- 129

Query: 448 TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHL 507
           + C  L  D G  +    D    TPLH+A    H   V +LLN GA ++        LH 
Sbjct: 130 SECVRLLIDVGANL-EAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHH 188

Query: 508 AAMSGYTKTIELL 520
           AA       IE+L
Sbjct: 189 AAKVKNVDLIEML 201



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 52  HQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ--QHVETSVL 109
           H+A    ++  +  + +   +L A D    TPLHVA   E LD ++ LL    +V  + L
Sbjct: 122 HEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL 181

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKY 135
           +E     +H A ++  V ++++  ++
Sbjct: 182 HE---TALHHAAKVKNVDLIEMLIEF 204



 Score = 35.5 bits (78), Expect = 1.1
 Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 13/161 (8%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H AS +     +  +      ++A++  G+TPL  A  + +++ ++ LL        
Sbjct: 54  TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLS------- 106

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE----HGRTALHFAAIHDHDLCA 164
              K   P++ A+ L++  +       + L +V    E    H  T LH A   +H  C 
Sbjct: 107 YGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 166

Query: 165 KILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           K+L+ +  A            +H AAK  +   IE+ +++G
Sbjct: 167 KVLL-NAGAN-VNAAKLHETALHHAAKVKNVDLIEMLIEFG 205


>AK125565-1|BAC86204.1|  452|Homo sapiens protein ( Homo sapiens
           cDNA FLJ43577 fis, clone SKMUS2006394, weakly  similar
           to Mus musculus ankyrin repeat-containing protein Asb-4
           mRNA. ).
          Length = 452

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 69/227 (30%), Positives = 100/227 (44%), Gaps = 24/227 (10%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT-VHTLIRLGADIQ 354
           TP+H AA   H E++  L+   +  +     R +  L  A  AG    VH L+  GAD  
Sbjct: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA--LHEACAAGHTACVHVLLVAGADPN 160

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
           + D + +  LHL     G LE     C +   +   ++    +    +PLH A+R GH+ 
Sbjct: 161 IADQDGKRPLHLC-RGPGTLE-----CAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214

Query: 415 SLENLIRLGACINLKNNNNESPLHFA------------ARYGRFHTACQLLDSDKGTFII 462
             + L+R GAC + +N    +PL  A            A   R    C LL S       
Sbjct: 215 LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD--A 272

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
           + +D +   PLH+A R GH  VV LLL+ G   +  D+ G  PLH A
Sbjct: 273 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 59/182 (32%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G + LH A   GH   +  L+  GA  N+ + + + PLH     G    A  LL    G 
Sbjct: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF--GA 190

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIE 518
            +   S+ E  TPLH+A+R GH  +  LLL RGA    R+  G  PL LAA     ++I 
Sbjct: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL-LAACDVRCQSIT 249

Query: 519 LLHSVHSHLL-------------DQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
              +  +  L             D  D+D    LHLA      + + LLLS  C +S N 
Sbjct: 250 DAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS--CGVSANT 307

Query: 566 MD 567
           MD
Sbjct: 308 MD 309



 Score = 60.1 bits (139), Expect = 5e-08
 Identities = 74/289 (25%), Positives = 117/289 (40%), Gaps = 25/289 (8%)

Query: 251 TQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIV 310
           T + +L+TP+H+A ++G  ++++L+   + +   A          T +H A    H   V
Sbjct: 96  TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSA------PGGRTALHEACAAGHTACV 149

Query: 311 NYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ-LKDINSRNVLHLVVM 369
           + L+  G+D N  D++ + PL L            L+R GA +    +      LH+   
Sbjct: 150 HVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR 209

Query: 370 NGG-RLEDF---AASCKDHCEKSLLQLLNEKDNTGCSPL--HYASREGHIRSLENLIRLG 423
            G   L D      +C D         L    +  C  +    A+    ++    L+  G
Sbjct: 210 LGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAG 269

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR----- 478
           A  +  + + + PLH A R G  H A   L    G    N  D  G TPLH A +     
Sbjct: 270 ADADAADQDKQRPLHLACRRG--HAAVVELLLSCGV-SANTMDYGGHTPLHCALQGPAAA 326

Query: 479 --EGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHS 525
             +    VV  LLN GA+  R   G  P  L   S   +TIE+L + +S
Sbjct: 327 LAQSPEHVVRALLNHGAV--RVWPGALPKVLERWSTCPRTIEVLMNTYS 373



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 57/229 (24%), Positives = 90/229 (39%), Gaps = 19/229 (8%)

Query: 111 EKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD 170
           E+   P+H+A       VL++  + ++  +   GG   RTALH A    H  C  +L+  
Sbjct: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG---RTALHEACAAGHTACVHVLLV- 154

Query: 171 LDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
             A+      +G  P+H      +    E+ L++G +     E+       E   PLH A
Sbjct: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE-------EEETPLHVA 207

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC---AQGALDIVK-----LMFTMQPKE 282
              G ++  +L LR GA    +  +  TP+  AC    Q   D        L        
Sbjct: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 267

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
             A   + D  K  P+H A    H  +V  L++ G   N +D    +PL
Sbjct: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 316



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 34/91 (37%), Positives = 44/91 (48%), Gaps = 1/91 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           TPLH+A+  GHT V+ LLL R A       GR  LH A  +G+T  + +L  V     + 
Sbjct: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL-LVAGADPNI 161

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            D+DG   LHL           LLL  G R+
Sbjct: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARV 192



 Score = 49.6 bits (113), Expect = 6e-05
 Identities = 41/125 (32%), Positives = 55/125 (44%), Gaps = 5/125 (4%)

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           +PLH AA  G       LL          +S   G T LH A   GHT  VH+LL  GA 
Sbjct: 103 TPLHVAASRGHTEVLRLLLRRRARP----DSAPGGRTALHEACAAGHTACVHVLLVAGAD 158

Query: 495 LH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
            +  D +G+ PLHL    G  +  ELL    + +  + +++  T LH+A          L
Sbjct: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218

Query: 554 LLSMG 558
           LL  G
Sbjct: 219 LLRRG 223



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 58/229 (25%), Positives = 93/229 (40%), Gaps = 29/229 (12%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+ +  +RL L   +R     G GRTA H+A A  +T  +H +     D N  D  
Sbjct: 108 AASRGHTE-VLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIADQD 165

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLN-EKCQAPIHMATELNKVSVLQVFAKYKSL 138
           G  PLH+      L+  E LL+        + E+ + P+H+A  L  V +  +  +  + 
Sbjct: 166 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 225

Query: 139 FNVNQGGEHGRTALHFA------AIHDHD--------LCAKILITDLDAEWKKPCNNGYY 184
            +       G T L  A      +I D +        LC+ +L    DA+      +   
Sbjct: 226 PDARNA--EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADAD--AADQDKQR 281

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           P+H A +   +  +E+ L  G           +  D  G+ PLH A+ G
Sbjct: 282 PLHLACRRGHAAVVELLLSCGVS--------ANTMDYGGHTPLHCALQG 322



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 4/112 (3%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G   LH A   G    V + L +GA  +    D   P+HL    G L+  +L+     + 
Sbjct: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 192

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
                   + ++ TP+H AA   H E+ + L+  G+  +  + E  +PLL A
Sbjct: 193 D----GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 240



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 12/90 (13%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
           ++   L L +GA       D   P+HLAC +G   +V+L+ +           + D    
Sbjct: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSC-----GVSANTMDYGGH 313

Query: 296 TPIHC------AAMFDHPE-IVNYLINEGS 318
           TP+HC      AA+   PE +V  L+N G+
Sbjct: 314 TPLHCALQGPAAALAQSPEHVVRALLNHGA 343


>AF417920-1|AAL59159.1|  429|Homo sapiens ASB-10 protein.
          Length = 429

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 69/227 (30%), Positives = 100/227 (44%), Gaps = 24/227 (10%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT-VHTLIRLGADIQ 354
           TP+H AA   H E++  L+   +  +     R +  L  A  AG    VH L+  GAD  
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA--LHEACAAGHTACVHVLLVAGADPN 175

Query: 355 LKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIR 414
           + D + +  LHL     G LE     C +   +   ++    +    +PLH A+R GH+ 
Sbjct: 176 IADQDGKRPLHLC-RGPGTLE-----CAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 229

Query: 415 SLENLIRLGACINLKNNNNESPLHFA------------ARYGRFHTACQLLDSDKGTFII 462
             + L+R GAC + +N    +PL  A            A   R    C LL S       
Sbjct: 230 LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD--A 287

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLA 508
           + +D +   PLH+A R GH  VV LLL+ G   +  D+ G  PLH A
Sbjct: 288 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334



 Score = 64.5 bits (150), Expect = 2e-09
 Identities = 59/182 (32%), Positives = 80/182 (43%), Gaps = 19/182 (10%)

Query: 400 GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
           G + LH A   GH   +  L+  GA  N+ + + + PLH     G    A  LL    G 
Sbjct: 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF--GA 205

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIE 518
            +   S+ E  TPLH+A+R GH  +  LLL RGA    R+  G  PL LAA     ++I 
Sbjct: 206 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL-LAACDVRCQSIT 264

Query: 519 LLHSVHSHLL-------------DQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
              +  +  L             D  D+D    LHLA      + + LLLS  C +S N 
Sbjct: 265 DAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS--CGVSANT 322

Query: 566 MD 567
           MD
Sbjct: 323 MD 324



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 57/229 (24%), Positives = 90/229 (39%), Gaps = 19/229 (8%)

Query: 111 EKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITD 170
           E+   P+H+A       VL++  + ++  +   GG   RTALH A    H  C  +L+  
Sbjct: 114 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG---RTALHEACAAGHTACVHVLLV- 169

Query: 171 LDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSA 230
             A+      +G  P+H      +    E+ L++G +     E+       E   PLH A
Sbjct: 170 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE-------EEETPLHVA 222

Query: 231 VHGGDIKAVELCLRSGAKISTQQHDLSTPVHLAC---AQGALDIVK-----LMFTMQPKE 282
              G ++  +L LR GA    +  +  TP+  AC    Q   D        L        
Sbjct: 223 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 282

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
             A   + D  K  P+H A    H  +V  L++ G   N +D    +PL
Sbjct: 283 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 331



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 34/91 (37%), Positives = 44/91 (48%), Gaps = 1/91 (1%)

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           TPLH+A+  GHT V+ LLL R A       GR  LH A  +G+T  + +L  V     + 
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL-LVAGADPNI 176

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMGCRL 561
            D+DG   LHL           LLL  G R+
Sbjct: 177 ADQDGKRPLHLCRGPGTLECAELLLRFGARV 207



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 64/258 (24%), Positives = 103/258 (39%), Gaps = 23/258 (8%)

Query: 251 TQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIV 310
           T + +L+TP+H+A ++G  ++++L+   + +   A          T +H A    H   V
Sbjct: 111 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSA------PGGRTALHEACAAGHTACV 164

Query: 311 NYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQ-LKDINSRNVLHLVVM 369
           + L+  G+D N  D++ + PL L            L+R GA +    +      LH+   
Sbjct: 165 HVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR 224

Query: 370 NGG-RLEDF---AASCKDHCEKSLLQLLNEKDNTGCSPL--HYASREGHIRSLENLIRLG 423
            G   L D      +C D         L    +  C  +    A+    ++    L+  G
Sbjct: 225 LGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAG 284

Query: 424 ACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASR----- 478
           A  +  + + + PLH A R G  H A   L    G    N  D  G TPLH A +     
Sbjct: 285 ADADAADQDKQRPLHLACRRG--HAAVVELLLSCGV-SANTMDYGGHTPLHCALQGPAAA 341

Query: 479 --EGHTRVVHLLLNRGAL 494
             +    VV  LLN GA+
Sbjct: 342 LAQSPEHVVRALLNHGAV 359



 Score = 49.6 bits (113), Expect = 6e-05
 Identities = 41/125 (32%), Positives = 55/125 (44%), Gaps = 5/125 (4%)

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           +PLH AA  G       LL          +S   G T LH A   GHT  VH+LL  GA 
Sbjct: 118 TPLHVAASRGHTEVLRLLLRRRARP----DSAPGGRTALHEACAAGHTACVHVLLVAGAD 173

Query: 495 LH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
            +  D +G+ PLHL    G  +  ELL    + +  + +++  T LH+A          L
Sbjct: 174 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 233

Query: 554 LLSMG 558
           LL  G
Sbjct: 234 LLRRG 238



 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 58/229 (25%), Positives = 93/229 (40%), Gaps = 29/229 (12%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G+ +  +RL L   +R     G GRTA H+A A  +T  +H +     D N  D  
Sbjct: 123 AASRGHTE-VLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIADQD 180

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLN-EKCQAPIHMATELNKVSVLQVFAKYKSL 138
           G  PLH+      L+  E LL+        + E+ + P+H+A  L  V +  +  +  + 
Sbjct: 181 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 240

Query: 139 FNVNQGGEHGRTALHFA------AIHDHD--------LCAKILITDLDAEWKKPCNNGYY 184
            +       G T L  A      +I D +        LC+ +L    DA+      +   
Sbjct: 241 PDARNA--EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADAD--AADQDKQR 296

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           P+H A +   +  +E+ L  G           +  D  G+ PLH A+ G
Sbjct: 297 PLHLACRRGHAAVVELLLSCGVS--------ANTMDYGGHTPLHCALQG 337



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 4/112 (3%)

Query: 223 GNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKE 282
           G   LH A   G    V + L +GA  +    D   P+HL    G L+  +L+     + 
Sbjct: 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 207

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
                   + ++ TP+H AA   H E+ + L+  G+  +  + E  +PLL A
Sbjct: 208 D----GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 255



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 12/90 (13%)

Query: 236 IKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKM 295
           ++   L L +GA       D   P+HLAC +G   +V+L+ +           + D    
Sbjct: 274 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSC-----GVSANTMDYGGH 328

Query: 296 TPIHC------AAMFDHPE-IVNYLINEGS 318
           TP+HC      AA+   PE +V  L+N G+
Sbjct: 329 TPLHCALQGPAAALAQSPEHVVRALLNHGA 358


>AF403031-1|AAL57350.1|  286|Homo sapiens ankyrin repeat
           domain-containing SOCS box protein Asb-13 protein.
          Length = 286

 Score = 74.1 bits (174), Expect = 3e-12
 Identities = 50/181 (27%), Positives = 88/181 (48%), Gaps = 14/181 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+HEAA+   S  ++  ++ G    C  +  +     +   PLH+A   G  + V+L L 
Sbjct: 30  PVHEAAQRGESLQLQQLIESG---ACVNQVTV-----DSITPLHAASLQGQARCVQLLLA 81

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
           +GA++  +  D STP+  ACA G+++ VKL+ +   K      T+      +P+H A M 
Sbjct: 82  AGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA------SPLHEACMS 135

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
              E V  LI+ G+++   D    +PL +A +R     V  L+  GA++    ++   + 
Sbjct: 136 GDSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALH 195

Query: 365 H 365
           H
Sbjct: 196 H 196



 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 4/177 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +P+H A++ G    L+ LI  GAC+N    ++ +PLH A+  G+      LL +      
Sbjct: 29  TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ--- 85

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLH 521
           ++  + +G TPL  A   G    V LLL+ GA ++      +PLH A MSG ++ + LL 
Sbjct: 86  VDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGDSECVRLLI 145

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
            V ++ L+  D    T LH+A        + +LL+ G  ++   +  +A+ +A   K
Sbjct: 146 DVGAN-LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVK 201



 Score = 52.8 bits (121), Expect = 7e-06
 Identities = 57/213 (26%), Positives = 91/213 (42%), Gaps = 19/213 (8%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H AA       +  LI  G+ +N +  +  +PL  A+ +   R V  L+  GA +  
Sbjct: 29  TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 88

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNT---GCSPLHYASREGH 412
           ++I+    L           D  AS    C K LL     K N      SPLH A   G 
Sbjct: 89  RNIDGSTPLC----------DACASGSIECVKLLLS-YGAKVNPPLYTASPLHEACMSGD 137

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +  LI +GA +   + +  +PLH A    R H  C  +  + G  +      E  T 
Sbjct: 138 SECVRLLIDVGANLEAHDCHFGTPLHVAC--AREHLDCVKVLLNAGANVNAAKLHE--TA 193

Query: 473 LHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
           LH A++  +  ++ +L+  G  ++ RD+ G+ P
Sbjct: 194 LHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 226



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 56/193 (29%), Positives = 80/193 (41%), Gaps = 11/193 (5%)

Query: 328 RSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEK 387
           R+P+  AA R     +  LI  GA +    ++S   LH   + G       A C      
Sbjct: 28  RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG------QARCVQLLLA 81

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
           +  Q+ + ++  G +PL  A   G I  ++ L+  GA +N       SPLH A   G   
Sbjct: 82  AGAQV-DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSG--D 137

Query: 448 TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHL 507
           + C  L  D G  +    D    TPLH+A    H   V +LLN GA ++        LH 
Sbjct: 138 SECVRLLIDVGANL-EAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHH 196

Query: 508 AAMSGYTKTIELL 520
           AA       IE+L
Sbjct: 197 AAKVKNVDLIEML 209



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 52  HQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ--QHVETSVL 109
           H+A    ++  +  + +   +L A D    TPLHVA   E LD ++ LL    +V  + L
Sbjct: 130 HEACMSGDSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL 189

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKY 135
           +E     +H A ++  V ++++  ++
Sbjct: 190 HE---TALHHAAKVKNVDLIEMLIEF 212



 Score = 35.1 bits (77), Expect = 1.5
 Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 13/161 (8%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H AS +     +  +      ++A++  G+TPL  A  + +++ ++ LL        
Sbjct: 62  TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLS------- 114

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE----HGRTALHFAAIHDHDLCA 164
              K   P++ A+ L++  +       + L +V    E    H  T LH A   +H  C 
Sbjct: 115 YGAKVNPPLYTASPLHEACMSGDSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 174

Query: 165 KILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           K+L+ +  A            +H AAK  +   IE+ +++G
Sbjct: 175 KVLL-NAGAN-VNAAKLHETALHHAAKVKNVDLIEMLIEFG 213


>BC050529-1|AAH50529.1| 1050|Homo sapiens ankyrin repeat domain 27
           (VPS9 domain) protein.
          Length = 1050

 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 50/156 (32%), Positives = 74/156 (47%), Gaps = 5/156 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N     G SPLH A+  G    +  L++ GA    +N +   PLH A + G F     L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMS 511
           LDS+      N+ D  G TPL  A   GH  +V LLL  GA ++  +N G   LH A + 
Sbjct: 797 LDSNAKP---NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
            +   +ELL  +H   +  ++K   T++  A   +K
Sbjct: 854 KHVFVVELL-LLHGASVQVLNKRQRTAVDCAEQNSK 888



 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 100/443 (22%), Positives = 174/443 (39%), Gaps = 34/443 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           + G T LH AA+        +L++   A       +G  P+H A +        + L + 
Sbjct: 461 DRGHTPLHVAAVCGQASLIDLLVSK-GAMVNATDYHGATPLHLACQKGYQSVTLLLLHY- 518

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAV---HGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                  +    + DN GN PLH A    H   +KA+        ++        TP+H+
Sbjct: 519 -------KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 571

Query: 263 ACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN-YLIN----EG 317
           A   G   +++ +      +  A     +  K TP+ CA       ++  Y ++    + 
Sbjct: 572 AARWGYQGVIETLL-----QNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQK 626

Query: 318 SDINPLDKERRS--PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RL 374
           S   P+   +RS   +   +S + + ++    R   +   KD      L   V +G   +
Sbjct: 627 SSEAPVQSPQRSVDSISQESSTSSFSSMSASSR--QEETKKDYREVEKLLRAVADGDLEM 684

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS-LENLIRLGACINLKNNNN 433
             +     +   +     ++  D   C PL    +    +  L  +   G  +N+ + + 
Sbjct: 685 VRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG 744

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            SPLH AA +GR      LL         N        PLH+A ++GH +VV  LL+  A
Sbjct: 745 SSPLHVAALHGRADLIPLLLKHGANAGARNADQA---VPLHLACQQGHFQVVKCLLDSNA 801

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
             + +D +G  PL  A   G+ + + LL   H   ++  +  GNT+LH A +E     + 
Sbjct: 802 KPNKKDLSGNTPLIYACSGGHHELVALLLQ-HGASINASNNKGNTALHEAVIEKHVFVVE 860

Query: 553 LLLSMGCRLS-YNNMDMSAIDYA 574
           LLL  G  +   N    +A+D A
Sbjct: 861 LLLLHGASVQVLNKRQRTAVDCA 883



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 79/349 (22%), Positives = 128/349 (36%), Gaps = 21/349 (6%)

Query: 32  LYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD---LNAKDNAGNTPLHVAV 88
           L L   +   V+D  G T  H A    + + +  +  Y  +   L+  +  G+TPLH+A 
Sbjct: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAA 573

Query: 89  ENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHG 148
                  IE LLQ    T + N   + P+  A  LN   +L V   Y   F   Q     
Sbjct: 574 RWGYQGVIETLLQNGASTEIQNRLKETPLKCA--LNS-KILSVMEAYHLSFERRQKSSEA 630

Query: 149 ------RTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
                 R+    +        + +  +    E KK        +  A  +     +   L
Sbjct: 631 PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYRE-VEKLLRAVADGDLEMVRYLL 689

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI-KAVELCLRSGAKISTQQHDLSTPVH 261
           +W E+     E  +S  D E   PL          K +     SG  ++    D S+P+H
Sbjct: 690 EWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLH 749

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSC-DVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           +A   G  D++ L+       KH       +  +  P+H A    H ++V  L++  +  
Sbjct: 750 VAALHGRADLIPLLL------KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           N  D    +PL+ A S      V  L++ GA I   +      LH  V+
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 49/140 (35%), Positives = 73/140 (52%), Gaps = 6/140 (4%)

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
           +++   +PLH AA  G+  +   LL S KG  ++N +D  G TPLH+A ++G+  V  LL
Sbjct: 459 RDDRGHTPLHVAAVCGQA-SLIDLLVS-KGA-MVNATDYHGATPLHLACQKGYQSVTLLL 515

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATME 545
           L+  A    +D+NG  PLHLA   G+   ++ L  + V S  LD  ++ G+T LH+A   
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575

Query: 546 NKPSSIALLLSMGCRLSYNN 565
                I  LL  G      N
Sbjct: 576 GYQGVIETLLQNGASTEIQN 595



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 92/415 (22%), Positives = 161/415 (38%), Gaps = 20/415 (4%)

Query: 34  LSEPSRLAV--RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L++PS +    RD RG T  H A+     +++  + +    +NA D  G TPLH+A +  
Sbjct: 448 LNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKG 507

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK-SLFNVNQGGEHGRT 150
                  LL       V +     P+H+A        ++    Y      ++ G E G T
Sbjct: 508 YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDT 567

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   +    + L+ +  A  +        P+  A  +     +E +    E+R  
Sbjct: 568 PLHIAARWGYQGVIETLLQN-GASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQK 626

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL-ACAQGAL 269
           + E  +          + S        +      S  +  T++        L A A G L
Sbjct: 627 SSEAPVQSPQRS----VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDL 682

Query: 270 DIVK--LMFTMQP-KEKHACLTSCDVQKMTPI-HCAAMFDHPEIVNYLINEGSDINPLDK 325
           ++V+  L +T +  ++    +++ D +   P+  C       + +  +   G  +N   +
Sbjct: 683 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQ 742

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHC 385
           +  SPL +AA       +  L++ GA+   ++ +    LHL    G     F       C
Sbjct: 743 DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG----HFQVV---KC 795

Query: 386 EKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
                   N+KD +G +PL YA   GH   +  L++ GA IN  NN   + LH A
Sbjct: 796 LLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 850



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 96/402 (23%), Positives = 171/402 (42%), Gaps = 50/402 (12%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D+ G+ PLH A   G    ++L +  GA ++   +  +TP+HLAC +G   +  L+   +
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD--KERRSPLLLAASR 337
                A     D    TP+H A  + H + V  L+    +   LD   E+    L  A+R
Sbjct: 520 -----ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574

Query: 338 AGWR-TVHTLIRLGADIQLKD----------INSR--NVLHLVVMNGGRLEDFAASCKDH 384
            G++  + TL++ GA  ++++          +NS+  +V+    ++  R +  + +    
Sbjct: 575 WGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 634

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGH----IRSLENLIRLGACINLKNNN-----NES 435
            ++S+  +  E   +  S +  +SR+       R +E L+R  A  +L+         E 
Sbjct: 635 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694

Query: 436 PLHFA-----ARYGRF-HTACQLLDSDKGTFIINESDGEGLTPLHIASREG----HTRVV 485
            L  A     A    F H  CQ          + +    GL  +++ S++G    H   +
Sbjct: 695 DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL-GVNVTSQDGSSPLHVAAL 753

Query: 486 H-------LLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           H       LLL  GA    R+ +   PLHLA   G+ + ++ L   ++   ++ D  GNT
Sbjct: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK-PNKKDLSGNT 812

Query: 538 SLHLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYK 578
            L  A        +ALLL  G  + + NN   +A+  A+  K
Sbjct: 813 PLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 5/160 (3%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           +++   +G+ PLH A   G    + L L+ GA    +  D + P+HLAC QG   +VK +
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                K         D+   TP+  A    H E+V  L+  G+ IN  + +  + L  A 
Sbjct: 797 LDSNAKPNKK-----DLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAV 851

Query: 336 SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
                  V  L+  GA +Q+ +   R  +     N   +E
Sbjct: 852 IEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIME 891



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 15/150 (10%)

Query: 383 DHCEKSLLQLLNE--------KDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNE 434
           D CEK +   LN+        +D+ G +PLH A+  G    ++ L+  GA +N  + +  
Sbjct: 438 DDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA 497

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           +PLH A + G + +   LL   K +  + +++G   TPLH+A   GH   V  L+     
Sbjct: 498 TPLHLACQKG-YQSVTLLLLHYKASAEVQDNNGN--TPLHLACTYGHEDCVKALVYYDVE 554

Query: 495 LHR----DHNGRNPLHLAAMSGYTKTIELL 520
             R    +  G  PLH+AA  GY   IE L
Sbjct: 555 SCRLDIGNEKGDTPLHIAARWGYQGVIETL 584



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 37/160 (23%), Positives = 71/160 (44%), Gaps = 7/160 (4%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           +P+H AA+    +++  L+  G++    + ++  PL LA  +  ++ V  L+   A    
Sbjct: 746 SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 805

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           KD++    L +   +GG  E   A    H        +N  +N G + LH A  E H+  
Sbjct: 806 KDLSGNTPL-IYACSGGHHE-LVALLLQHGAS-----INASNNKGNTALHEAVIEKHVFV 858

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           +E L+  GA + + N    + +  A +  +     Q++ S
Sbjct: 859 VELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPS 898



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 3/102 (2%)

Query: 32  LYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L +S+ + +   D  G T  H A  +   ++   + +Y      +DN GNTPLH+A    
Sbjct: 481 LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG 540

Query: 92  ALDAIEYLLQQHVETSVL---NEKCQAPIHMATELNKVSVLQ 130
             D ++ L+   VE+  L   NEK   P+H+A       V++
Sbjct: 541 HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582



 Score = 43.2 bits (97), Expect = 0.006
 Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 1/90 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G T    A +  +  ++  +  +   +NA +N GNT LH AV  + +  +E LL  
Sbjct: 806 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 865

Query: 103 HVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                VLN++ +  +  A + +K+  +LQV
Sbjct: 866 GASVQVLNKRQRTAVDCAEQNSKIMELLQV 895



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 33/133 (24%), Positives = 50/133 (37%), Gaps = 3/133 (2%)

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N     G++PLHVA  +   D I  LL+        N     P+H+A +     V++  
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
               S    N+    G T L +A    H     +L+    A      N G   +HEA   
Sbjct: 797 --LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH-GASINASNNKGNTALHEAVIE 853

Query: 193 ASSRTIEVFLQWG 205
                +E+ L  G
Sbjct: 854 KHVFVVELLLLHG 866



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/122 (18%), Positives = 52/122 (42%), Gaps = 2/122 (1%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G +  H A+     +++  +  +  +  A++     PLH+A +      ++ LL  + + 
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +  +     P+  A       ++ +  ++ +  ++N     G TALH A I  H    ++
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGA--SINASNNKGNTALHEAVIEKHVFVVEL 861

Query: 167 LI 168
           L+
Sbjct: 862 LL 863



 Score = 35.1 bits (77), Expect = 1.5
 Identities = 24/104 (23%), Positives = 41/104 (39%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D + L L   +    R+       H A  + +  ++  + +     N KD +GNTPL  A
Sbjct: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
                 + +  LLQ     +  N K    +H A     V V+++
Sbjct: 818 CSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 861


>BC030990-1|AAH30990.1|  276|Homo sapiens ZDHHC17 protein protein.
          Length = 276

 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 10/179 (5%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 93  VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 152

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHR-DHNGRNPLHLAAM 510
           L+       +I   DGEG + +H+A++ GHT +V  L+ +G  +   D NG  PL  AA 
Sbjct: 153 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAY 209

Query: 511 SGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
             ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+
Sbjct: 210 RTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNI 266



 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 50/155 (32%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 97  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 151

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA 338
           Q  +  A  +  D +  + IH AA F H  IV YLI +G D++ +D+   +PL+ AA R 
Sbjct: 152 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRT 211

Query: 339 -GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                   L+     + L D   +N  LH  V+ G
Sbjct: 212 HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 246



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 53/181 (29%), Positives = 89/181 (49%), Gaps = 18/181 (9%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 86  LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 137

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G  HT+       KG   ++
Sbjct: 138 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFG--HTSIVAYLIAKGQ-DVD 194

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 195 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 253

Query: 520 L 520
           L
Sbjct: 254 L 254



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 48/195 (24%), Positives = 76/195 (38%), Gaps = 14/195 (7%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 92  DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 151

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEA 189
              KY +  ++  G   G + +H AA   H  + A ++    D +      NG  P+  A
Sbjct: 152 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD--QNGMTPLMWA 207

Query: 190 AKNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAK 248
           A    S      L        T    ++L D    N  LH AV  G+   + L L +GA 
Sbjct: 208 AYRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 260

Query: 249 ISTQQHDLSTPVHLA 263
           +  Q        H+A
Sbjct: 261 VDAQNIKAILRCHMA 275



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 32/161 (19%), Positives = 74/161 (45%), Gaps = 6/161 (3%)

Query: 11  KVNLSFFVQAAESGNVDDFMRLYLSEPSRLAVRDGR-GRTAAHQASARNNTNILHFINNY 69
           K N++    AA +  +D  ++ Y+S+ + +    G    T  H A+ + + +++  +  Y
Sbjct: 98  KENVTLLHWAAINNRID-LVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 156

Query: 70  AGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMAT-ELNKVSV 128
             D +  D  G + +H+A +      + YL+ +  +  ++++    P+  A    + V  
Sbjct: 157 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 216

Query: 129 LQVFAKYKSLFNVNQGGE-HGRTALHFAAIHDHDLCAKILI 168
            ++   +    +VN G + H  TALH+A +  +     +L+
Sbjct: 217 TRLLLTFN--VSVNLGDKYHKNTALHWAVLAGNTTVISLLL 255


>AL834335-1|CAD39003.1|  407|Homo sapiens hypothetical protein
           protein.
          Length = 407

 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 50/156 (32%), Positives = 74/156 (47%), Gaps = 5/156 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N     G SPLH A+  G    +  L++ GA    +N +   PLH A + G F     L
Sbjct: 94  VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 153

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMS 511
           LDS+      N+ D  G TPL  A   GH  +V LLL  GA ++  +N G   LH A + 
Sbjct: 154 LDSNAKP---NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 210

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
            +   +ELL  +H   +  ++K   T++  A   +K
Sbjct: 211 KHVFVVELL-LLHGASVQVLNKRQRTAVDCAEQNSK 245



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 48/154 (31%), Positives = 73/154 (47%), Gaps = 6/154 (3%)

Query: 423 GACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHT 482
           G  +N+ + +  SPLH AA +GR      LL         N        PLH+A ++GH 
Sbjct: 91  GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQA---VPLHLACQQGHF 147

Query: 483 RVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHL 541
           +VV  LL+  A  + +D +G  PL  A   G+ + + LL   H   ++  +  GNT+LH 
Sbjct: 148 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQ-HGASINASNNKGNTALHE 206

Query: 542 ATMENKPSSIALLLSMGCRLS-YNNMDMSAIDYA 574
           A +E     + LLL  G  +   N    +A+D A
Sbjct: 207 AVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCA 240



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 5/160 (3%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           +++   +G+ PLH A   G    + L L+ GA    +  D + P+HLAC QG   +VK +
Sbjct: 94  VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 153

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                K         D+   TP+  A    H E+V  L+  G+ IN  + +  + L  A 
Sbjct: 154 LDSNAKPNKK-----DLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAV 208

Query: 336 SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
                  V  L+  GA +Q+ +   R  +     N   +E
Sbjct: 209 IEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIME 248



 Score = 53.6 bits (123), Expect = 4e-06
 Identities = 43/183 (23%), Positives = 71/183 (38%), Gaps = 8/183 (4%)

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI-KAVELCLRSGA 247
           A  +     +   L+W E+     E  +S  D E   PL          K +     SG 
Sbjct: 33  AVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL 92

Query: 248 KISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSC-DVQKMTPIHCAAMFDH 306
            ++    D S+P+H+A   G  D++ L+       KH       +  +  P+H A    H
Sbjct: 93  GVNVTSQDGSSPLHVAALHGRADLIPLLL------KHGANAGARNADQAVPLHLACQQGH 146

Query: 307 PEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHL 366
            ++V  L++  +  N  D    +PL+ A S      V  L++ GA I   +      LH 
Sbjct: 147 FQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHE 206

Query: 367 VVM 369
            V+
Sbjct: 207 AVI 209



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 37/160 (23%), Positives = 71/160 (44%), Gaps = 7/160 (4%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           +P+H AA+    +++  L+  G++    + ++  PL LA  +  ++ V  L+   A    
Sbjct: 103 SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 162

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           KD++    L +   +GG  E   A    H        +N  +N G + LH A  E H+  
Sbjct: 163 KDLSGNTPL-IYACSGGHHE-LVALLLQHGAS-----INASNNKGNTALHEAVIEKHVFV 215

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           +E L+  GA + + N    + +  A +  +     Q++ S
Sbjct: 216 VELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPS 255



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 36/124 (29%), Positives = 54/124 (43%), Gaps = 7/124 (5%)

Query: 317 GSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLED 376
           G  +N   ++  SPL +AA       +  L++ GA+   ++ +    LHL    G     
Sbjct: 91  GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG----H 146

Query: 377 FAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESP 436
           F       C        N+KD +G +PL YA   GH   +  L++ GA IN  NN   + 
Sbjct: 147 FQVV---KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTA 203

Query: 437 LHFA 440
           LH A
Sbjct: 204 LHEA 207



 Score = 43.2 bits (97), Expect = 0.006
 Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 1/90 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G T    A +  +  ++  +  +   +NA +N GNT LH AV  + +  +E LL  
Sbjct: 163 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 222

Query: 103 HVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                VLN++ +  +  A + +K+  +LQV
Sbjct: 223 GASVQVLNKRQRTAVDCAEQNSKIMELLQV 252



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 33/133 (24%), Positives = 50/133 (37%), Gaps = 3/133 (2%)

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N     G++PLHVA  +   D I  LL+        N     P+H+A +     V++  
Sbjct: 94  VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 153

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
               S    N+    G T L +A    H     +L+    A      N G   +HEA   
Sbjct: 154 --LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH-GASINASNNKGNTALHEAVIE 210

Query: 193 ASSRTIEVFLQWG 205
                +E+ L  G
Sbjct: 211 KHVFVVELLLLHG 223



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/122 (18%), Positives = 52/122 (42%), Gaps = 2/122 (1%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G +  H A+     +++  +  +  +  A++     PLH+A +      ++ LL  + + 
Sbjct: 101 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 160

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +  +     P+  A       ++ +  ++ +  ++N     G TALH A I  H    ++
Sbjct: 161 NKKDLSGNTPLIYACSGGHHELVALLLQHGA--SINASNNKGNTALHEAVIEKHVFVVEL 218

Query: 167 LI 168
           L+
Sbjct: 219 LL 220



 Score = 35.1 bits (77), Expect = 1.5
 Identities = 24/104 (23%), Positives = 41/104 (39%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D + L L   +    R+       H A  + +  ++  + +     N KD +GNTPL  A
Sbjct: 115 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 174

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
                 + +  LLQ     +  N K    +H A     V V+++
Sbjct: 175 CSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 218


>AK054561-1|BAB70755.1| 1060|Homo sapiens FLJ00040 protein protein.
          Length = 1060

 Score = 73.7 bits (173), Expect = 3e-12
 Identities = 50/156 (32%), Positives = 74/156 (47%), Gaps = 5/156 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N     G SPLH A+  G    +  L++ GA    +N +   PLH A + G F     L
Sbjct: 747 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 806

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMS 511
           LDS+      N+ D  G TPL  A   GH  +V LLL  GA ++  +N G   LH A + 
Sbjct: 807 LDSNAKP---NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 863

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENK 547
            +   +ELL  +H   +  ++K   T++  A   +K
Sbjct: 864 KHVFVVELL-LLHGASVQVLNKRQRTAVDCAEQNSK 898



 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 100/443 (22%), Positives = 174/443 (39%), Gaps = 34/443 (7%)

Query: 146 EHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           + G T LH AA+        +L++   A       +G  P+H A +        + L + 
Sbjct: 471 DRGHTPLHVAAVCGQASLIDLLVSK-GAMVNATDYHGATPLHLACQKGYQSVTLLLLHY- 528

Query: 206 EQRGCTREQMISLYDNEGNVPLHSAV---HGGDIKAVELCLRSGAKISTQQHDLSTPVHL 262
                  +    + DN GN PLH A    H   +KA+        ++        TP+H+
Sbjct: 529 -------KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 581

Query: 263 ACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVN-YLIN----EG 317
           A   G   +++ +      +  A     +  K TP+ CA       ++  Y ++    + 
Sbjct: 582 AARWGYQGVIETLL-----QNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQK 636

Query: 318 SDINPLDKERRS--PLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG-RL 374
           S   P+   +RS   +   +S + + ++    R   +   KD      L   V +G   +
Sbjct: 637 SSEAPVQSPQRSVDSISQESSTSSFSSMSASSR--QEETKKDYREVEKLLRAVADGDLEM 694

Query: 375 EDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS-LENLIRLGACINLKNNNN 433
             +     +   +     ++  D   C PL    +    +  L  +   G  +N+ + + 
Sbjct: 695 VRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG 754

Query: 434 ESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGA 493
            SPLH AA +GR      LL         N        PLH+A ++GH +VV  LL+  A
Sbjct: 755 SSPLHVAALHGRADLIPLLLKHGANAGARNADQA---VPLHLACQQGHFQVVKCLLDSNA 811

Query: 494 LLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIA 552
             + +D +G  PL  A   G+ + + LL   H   ++  +  GNT+LH A +E     + 
Sbjct: 812 KPNKKDLSGNTPLIYACSGGHHELVALLLQ-HGASINASNNKGNTALHEAVIEKHVFVVE 870

Query: 553 LLLSMGCRLS-YNNMDMSAIDYA 574
           LLL  G  +   N    +A+D A
Sbjct: 871 LLLLHGASVQVLNKRQRTAVDCA 893



 Score = 70.9 bits (166), Expect = 2e-11
 Identities = 79/349 (22%), Positives = 128/349 (36%), Gaps = 21/349 (6%)

Query: 32  LYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGD---LNAKDNAGNTPLHVAV 88
           L L   +   V+D  G T  H A    + + +  +  Y  +   L+  +  G+TPLH+A 
Sbjct: 524 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAA 583

Query: 89  ENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHG 148
                  IE LLQ    T + N   + P+  A  LN   +L V   Y   F   Q     
Sbjct: 584 RWGYQGVIETLLQNGASTEIQNRLKETPLKCA--LNS-KILSVMEAYHLSFERRQKSSEA 640

Query: 149 ------RTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFL 202
                 R+    +        + +  +    E KK        +  A  +     +   L
Sbjct: 641 PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYRE-VEKLLRAVADGDLEMVRYLL 699

Query: 203 QWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDI-KAVELCLRSGAKISTQQHDLSTPVH 261
           +W E+     E  +S  D E   PL          K +     SG  ++    D S+P+H
Sbjct: 700 EWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLH 759

Query: 262 LACAQGALDIVKLMFTMQPKEKHACLTSC-DVQKMTPIHCAAMFDHPEIVNYLINEGSDI 320
           +A   G  D++ L+       KH       +  +  P+H A    H ++V  L++  +  
Sbjct: 760 VAALHGRADLIPLLL------KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 813

Query: 321 NPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVM 369
           N  D    +PL+ A S      V  L++ GA I   +      LH  V+
Sbjct: 814 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 862



 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 49/140 (35%), Positives = 73/140 (52%), Gaps = 6/140 (4%)

Query: 429 KNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLL 488
           +++   +PLH AA  G+  +   LL S KG  ++N +D  G TPLH+A ++G+  V  LL
Sbjct: 469 RDDRGHTPLHVAAVCGQA-SLIDLLVS-KGA-MVNATDYHGATPLHLACQKGYQSVTLLL 525

Query: 489 LNRGALLH-RDHNGRNPLHLAAMSGYTKTIELL--HSVHSHLLDQIDKDGNTSLHLATME 545
           L+  A    +D+NG  PLHLA   G+   ++ L  + V S  LD  ++ G+T LH+A   
Sbjct: 526 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 585

Query: 546 NKPSSIALLLSMGCRLSYNN 565
                I  LL  G      N
Sbjct: 586 GYQGVIETLLQNGASTEIQN 605



 Score = 66.9 bits (156), Expect = 4e-10
 Identities = 92/415 (22%), Positives = 161/415 (38%), Gaps = 20/415 (4%)

Query: 34  LSEPSRLAV--RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L++PS +    RD RG T  H A+     +++  + +    +NA D  G TPLH+A +  
Sbjct: 458 LNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKG 517

Query: 92  ALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK-SLFNVNQGGEHGRT 150
                  LL       V +     P+H+A        ++    Y      ++ G E G T
Sbjct: 518 YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDT 577

Query: 151 ALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            LH AA   +    + L+ +  A  +        P+  A  +     +E +    E+R  
Sbjct: 578 PLHIAARWGYQGVIETLLQN-GASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQK 636

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHL-ACAQGAL 269
           + E  +          + S        +      S  +  T++        L A A G L
Sbjct: 637 SSEAPVQSPQRS----VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDL 692

Query: 270 DIVK--LMFTMQP-KEKHACLTSCDVQKMTPI-HCAAMFDHPEIVNYLINEGSDINPLDK 325
           ++V+  L +T +  ++    +++ D +   P+  C       + +  +   G  +N   +
Sbjct: 693 EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQ 752

Query: 326 ERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHC 385
           +  SPL +AA       +  L++ GA+   ++ +    LHL    G     F       C
Sbjct: 753 DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG----HFQVV---KC 805

Query: 386 EKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
                   N+KD +G +PL YA   GH   +  L++ GA IN  NN   + LH A
Sbjct: 806 LLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEA 860



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 96/402 (23%), Positives = 171/402 (42%), Gaps = 50/402 (12%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D+ G+ PLH A   G    ++L +  GA ++   +  +TP+HLAC +G   +  L+   +
Sbjct: 470 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 529

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLD--KERRSPLLLAASR 337
                A     D    TP+H A  + H + V  L+    +   LD   E+    L  A+R
Sbjct: 530 -----ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 584

Query: 338 AGWR-TVHTLIRLGADIQLKD----------INSR--NVLHLVVMNGGRLEDFAASCKDH 384
            G++  + TL++ GA  ++++          +NS+  +V+    ++  R +  + +    
Sbjct: 585 WGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 644

Query: 385 CEKSLLQLLNEKDNTGCSPLHYASREGH----IRSLENLIRLGACINLKNNN-----NES 435
            ++S+  +  E   +  S +  +SR+       R +E L+R  A  +L+         E 
Sbjct: 645 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 704

Query: 436 PLHFA-----ARYGRF-HTACQLLDSDKGTFIINESDGEGLTPLHIASREG----HTRVV 485
            L  A     A    F H  CQ          + +    GL  +++ S++G    H   +
Sbjct: 705 DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGL-GVNVTSQDGSSPLHVAAL 763

Query: 486 H-------LLLNRGALL-HRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNT 537
           H       LLL  GA    R+ +   PLHLA   G+ + ++ L   ++   ++ D  GNT
Sbjct: 764 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK-PNKKDLSGNT 822

Query: 538 SLHLATMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYK 578
            L  A        +ALLL  G  + + NN   +A+  A+  K
Sbjct: 823 PLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 864



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 5/160 (3%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           +++   +G+ PLH A   G    + L L+ GA    +  D + P+HLAC QG   +VK +
Sbjct: 747 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 806

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAA 335
                K         D+   TP+  A    H E+V  L+  G+ IN  + +  + L  A 
Sbjct: 807 LDSNAKPNKK-----DLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAV 861

Query: 336 SRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLE 375
                  V  L+  GA +Q+ +   R  +     N   +E
Sbjct: 862 IEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIME 901



 Score = 62.1 bits (144), Expect = 1e-08
 Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 15/150 (10%)

Query: 383 DHCEKSLLQLLNE--------KDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNE 434
           D CEK +   LN+        +D+ G +PLH A+  G    ++ L+  GA +N  + +  
Sbjct: 448 DDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA 507

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           +PLH A + G + +   LL   K +  + +++G   TPLH+A   GH   V  L+     
Sbjct: 508 TPLHLACQKG-YQSVTLLLLHYKASAEVQDNNGN--TPLHLACTYGHEDCVKALVYYDVE 564

Query: 495 LHR----DHNGRNPLHLAAMSGYTKTIELL 520
             R    +  G  PLH+AA  GY   IE L
Sbjct: 565 SCRLDIGNEKGDTPLHIAARWGYQGVIETL 594



 Score = 49.2 bits (112), Expect = 9e-05
 Identities = 37/160 (23%), Positives = 71/160 (44%), Gaps = 7/160 (4%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           +P+H AA+    +++  L+  G++    + ++  PL LA  +  ++ V  L+   A    
Sbjct: 756 SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 815

Query: 356 KDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRS 415
           KD++    L +   +GG  E   A    H        +N  +N G + LH A  E H+  
Sbjct: 816 KDLSGNTPL-IYACSGGHHE-LVALLLQHGAS-----INASNNKGNTALHEAVIEKHVFV 868

Query: 416 LENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDS 455
           +E L+  GA + + N    + +  A +  +     Q++ S
Sbjct: 869 VELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPS 908



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 3/102 (2%)

Query: 32  LYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENE 91
           L +S+ + +   D  G T  H A  +   ++   + +Y      +DN GNTPLH+A    
Sbjct: 491 LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG 550

Query: 92  ALDAIEYLLQQHVETSVL---NEKCQAPIHMATELNKVSVLQ 130
             D ++ L+   VE+  L   NEK   P+H+A       V++
Sbjct: 551 HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 592



 Score = 43.2 bits (97), Expect = 0.006
 Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 1/90 (1%)

Query: 43  RDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           +D  G T    A +  +  ++  +  +   +NA +N GNT LH AV  + +  +E LL  
Sbjct: 816 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 875

Query: 103 HVETSVLNEKCQAPIHMATELNKV-SVLQV 131
                VLN++ +  +  A + +K+  +LQV
Sbjct: 876 GASVQVLNKRQRTAVDCAEQNSKIMELLQV 905



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 33/133 (24%), Positives = 50/133 (37%), Gaps = 3/133 (2%)

Query: 73  LNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVF 132
           +N     G++PLHVA  +   D I  LL+        N     P+H+A +     V++  
Sbjct: 747 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 806

Query: 133 AKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKN 192
               S    N+    G T L +A    H     +L+    A      N G   +HEA   
Sbjct: 807 --LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQH-GASINASNNKGNTALHEAVIE 863

Query: 193 ASSRTIEVFLQWG 205
                +E+ L  G
Sbjct: 864 KHVFVVELLLLHG 876



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/122 (18%), Positives = 52/122 (42%), Gaps = 2/122 (1%)

Query: 47  GRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVET 106
           G +  H A+     +++  +  +  +  A++     PLH+A +      ++ LL  + + 
Sbjct: 754 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 813

Query: 107 SVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKI 166
           +  +     P+  A       ++ +  ++ +  ++N     G TALH A I  H    ++
Sbjct: 814 NKKDLSGNTPLIYACSGGHHELVALLLQHGA--SINASNNKGNTALHEAVIEKHVFVVEL 871

Query: 167 LI 168
           L+
Sbjct: 872 LL 873



 Score = 35.1 bits (77), Expect = 1.5
 Identities = 24/104 (23%), Positives = 41/104 (39%)

Query: 28  DFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVA 87
           D + L L   +    R+       H A  + +  ++  + +     N KD +GNTPL  A
Sbjct: 768 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 827

Query: 88  VENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQV 131
                 + +  LLQ     +  N K    +H A     V V+++
Sbjct: 828 CSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVEL 871


>BC110907-1|AAI10908.1|  515|Homo sapiens PPP1R12B protein protein.
          Length = 515

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>BC034430-1|AAH34430.1|  386|Homo sapiens PPP1R12B protein protein.
          Length = 386

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AL589762-3|CAH73375.1|  982|Homo sapiens protein phosphatase 1,
           regulatory (inhibitor) subunit 12B protein.
          Length = 982

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AL589762-2|CAH73374.1|  386|Homo sapiens protein phosphatase 1,
           regulatory (inhibitor) subunit 12B protein.
          Length = 386

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AL356953-9|CAI15935.1|  982|Homo sapiens protein phosphatase 1,
           regulatory (inhibitor) subunit 12B protein.
          Length = 982

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AL356953-8|CAI15934.1|  386|Homo sapiens protein phosphatase 1,
           regulatory (inhibitor) subunit 12B protein.
          Length = 386

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 63.7 bits (148), Expect = 4e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GV-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AB024494-1|BAC22089.1|  633|Homo sapiens huntingtin interacting
           protein 3 protein.
          Length = 633

 Score = 73.3 bits (172), Expect = 5e-12
 Identities = 62/210 (29%), Positives = 102/210 (48%), Gaps = 16/210 (7%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQ 451
           + + D    + LH+A+    I  ++  I  GA ++ L  + N +PLH+A R G      Q
Sbjct: 83  VRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQ 142

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVV--HLLLNRGALLHRDHNGRNPLHLAA 509
           L+       +I   DGEG + +H+A++ GHT +V  +L+     +   D NG  PL  AA
Sbjct: 143 LMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVVAYLIAKGQDVDMMDQNGMTPLMWAA 199

Query: 510 MSGYT---KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNM 566
              ++     + L  +V  +L D+  K  NT+LH A +    + I+LLL  G  +   N+
Sbjct: 200 YRTHSVDPTRLLLTFNVSVNLGDKYHK--NTALHWAVLAGNTTVISLLLEAGANVDAQNI 257

Query: 567 -DMSAIDYAIYYKFPEAALAMVTHEQRAKE 595
              SA+D A   K     + M+ H Q A++
Sbjct: 258 KGESALDLAKQRK----NVWMINHLQEARQ 283



 Score = 57.2 bits (132), Expect = 3e-07
 Identities = 57/203 (28%), Positives = 99/203 (48%), Gaps = 18/203 (8%)

Query: 346 LIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLL--QLLNEKDNTGCSP 403
           L+  G D++  D  +  +LH   +N  R++      K +  K  +  QL  + ++T   P
Sbjct: 76  LVEAGYDVRQPDKENVTLLHWAAINN-RID----LVKYYISKGAIVDQLGGDLNST---P 127

Query: 404 LHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIIN 463
           LH+A+R+GH+  +  L++ GA  +L +    S +H AA++G        L + KG   ++
Sbjct: 128 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVVAYLIA-KGQ-DVD 185

Query: 464 ESDGEGLTPLHIASREGH----TRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIEL 519
             D  G+TPL  A+   H    TR++ L  N    L   ++    LH A ++G T  I L
Sbjct: 186 MMDQNGMTPLMWAAYRTHSVDPTRLL-LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 244

Query: 520 LHSVHSHLLDQIDKDGNTSLHLA 542
           L    ++ +D  +  G ++L LA
Sbjct: 245 LLEAGAN-VDAQNIKGESALDLA 266



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 50/156 (32%), Positives = 71/156 (45%), Gaps = 9/156 (5%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL-STPVHLACAQGALDIVKLMFTM 278
           D E    LH A     I  V+  +  GA +     DL STP+H A  QG L +V     +
Sbjct: 87  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMV-----V 141

Query: 279 QPKEKHACLTSCDVQKMTPIHCAAMFDHPEIV-NYLINEGSDINPLDKERRSPLLLAASR 337
           Q  +  A  +  D +  + IH AA F H  IV  YLI +G D++ +D+   +PL+ AA R
Sbjct: 142 QLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVVAYLIAKGQDVDMMDQNGMTPLMWAAYR 201

Query: 338 A-GWRTVHTLIRLGADIQLKDINSRN-VLHLVVMNG 371
                    L+     + L D   +N  LH  V+ G
Sbjct: 202 THSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 237



 Score = 40.7 bits (91), Expect = 0.030
 Identities = 44/183 (24%), Positives = 69/183 (37%), Gaps = 11/183 (6%)

Query: 72  DLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQA-PIHMATELNKVSVLQ 130
           D+   D    T LH A  N  +D ++Y + +      L     + P+H AT    +S++ 
Sbjct: 82  DVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVV 141

Query: 131 VFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAA 190
              KY +  ++  G   G + +H AA   H       +     +      NG  P+  AA
Sbjct: 142 QLMKYGADPSLIDG--EGCSCIHLAAQFGHTSIVVAYLIAKGQDVDMMDQNGMTPLMWAA 199

Query: 191 KNASSRTIEVFLQWGEQRGCTREQMISLYDN-EGNVPLHSAVHGGDIKAVELCLRSGAKI 249
               S      L        T    ++L D    N  LH AV  G+   + L L +GA +
Sbjct: 200 YRTHSVDPTRLL-------LTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANV 252

Query: 250 STQ 252
             Q
Sbjct: 253 DAQ 255



 Score = 37.9 bits (84), Expect = 0.21
 Identities = 29/128 (22%), Positives = 61/128 (47%), Gaps = 3/128 (2%)

Query: 44  DGRGRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQ 102
           D    T  H A+  N  +++ ++I+  A       +  +TPLH A     L  +  L++ 
Sbjct: 87  DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 146

Query: 103 HVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDL 162
             + S+++ +  + IH+A +    S++  +   K   +V+   ++G T L +AA   H +
Sbjct: 147 GADPSLIDGEGCSCIHLAAQFGHTSIVVAYLIAKGQ-DVDMMDQNGMTPLMWAAYRTHSV 205

Query: 163 -CAKILIT 169
              ++L+T
Sbjct: 206 DPTRLLLT 213


>AK023196-1|BAB14456.1|  278|Homo sapiens ARPP-19) mRNA.  protein.
          Length = 278

 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 50/181 (27%), Positives = 87/181 (48%), Gaps = 14/181 (7%)

Query: 185 PIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLR 244
           P+HEAA+   S  ++  ++ G    C  +  +     +   PLH+A   G  + V+L L 
Sbjct: 22  PVHEAAQRGESLQLQQLIESG---ACVNQVTV-----DSITPLHAASLQGQARCVQLLLA 73

Query: 245 SGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMF 304
           +GA++  +  D STP+  ACA G+++ VKL  +   K      T+      +P+H A M 
Sbjct: 74  AGAQVDARNIDGSTPLCDACASGSIECVKLSLSYGAKVNPPLYTA------SPLHEACMS 127

Query: 305 DHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVL 364
              E V  LI+ G+++   D    +PL +A +R     V  L+  GA++    ++   + 
Sbjct: 128 GSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALH 187

Query: 365 H 365
           H
Sbjct: 188 H 188



 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 51/177 (28%), Positives = 87/177 (49%), Gaps = 4/177 (2%)

Query: 402 SPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFI 461
           +P+H A++ G    L+ LI  GAC+N    ++ +PLH A+  G+      LL +      
Sbjct: 21  TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ--- 77

Query: 462 INESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLH 521
           ++  + +G TPL  A   G    V L L+ GA ++      +PLH A MSG ++ + LL 
Sbjct: 78  VDARNIDGSTPLCDACASGSIECVKLSLSYGAKVNPPLYTASPLHEACMSGSSECVRLLI 137

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYK 578
            V ++ L+  D    T LH+A        + +LL+ G  ++   +  +A+ +A   K
Sbjct: 138 DVGAN-LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVK 193



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 61/234 (26%), Positives = 98/234 (41%), Gaps = 23/234 (9%)

Query: 278 MQPKEKHACLTSCDVQ---KMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLA 334
           M+P+    C    DV    + TP+H AA       +  LI  G+ +N +  +  +PL  A
Sbjct: 1   MEPRAADGCFLG-DVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAA 59

Query: 335 ASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLN 394
           + +   R V  L+  GA +  ++I+    L           D  AS    C K  L    
Sbjct: 60  SLQGQARCVQLLLAAGAQVDARNIDGSTPLC----------DACASGSIECVKLSLS-YG 108

Query: 395 EKDNT---GCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            K N      SPLH A   G    +  LI +GA +   + +  +PLH A    R H  C 
Sbjct: 109 AKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVAC--AREHLDCV 166

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNP 504
            +  + G  +      E  T LH A++  +  ++ +L+  G  ++ RD+ G+ P
Sbjct: 167 KVLLNAGANVNAAKLHE--TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218



 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 55/193 (28%), Positives = 79/193 (40%), Gaps = 11/193 (5%)

Query: 328 RSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEK 387
           R+P+  AA R     +  LI  GA +    ++S   LH   + G       A C      
Sbjct: 20  RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG------QARCVQLLLA 73

Query: 388 SLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFH 447
           +  Q+ + ++  G +PL  A   G I  ++  +  GA +N       SPLH A   G   
Sbjct: 74  AGAQV-DARNIDGSTPLCDACASGSIECVKLSLSYGAKVN-PPLYTASPLHEACMSGS-- 129

Query: 448 TACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHL 507
           + C  L  D G  +    D    TPLH+A    H   V +LLN GA ++        LH 
Sbjct: 130 SECVRLLIDVGANL-EAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHH 188

Query: 508 AAMSGYTKTIELL 520
           AA       IE+L
Sbjct: 189 AAKVKNVDLIEML 201



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 52  HQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ--QHVETSVL 109
           H+A    ++  +  + +   +L A D    TPLHVA   E LD ++ LL    +V  + L
Sbjct: 122 HEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL 181

Query: 110 NEKCQAPIHMATELNKVSVLQVFAKY 135
           +E     +H A ++  V ++++  ++
Sbjct: 182 HE---TALHHAAKVKNVDLIEMLIEF 204



 Score = 33.1 bits (72), Expect = 6.0
 Identities = 35/161 (21%), Positives = 67/161 (41%), Gaps = 13/161 (8%)

Query: 49  TAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSV 108
           T  H AS +     +  +      ++A++  G+TPL  A  + +++ ++  L        
Sbjct: 54  TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLSLSY------ 107

Query: 109 LNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQGGE----HGRTALHFAAIHDHDLCA 164
              K   P++ A+ L++  +       + L +V    E    H  T LH A   +H  C 
Sbjct: 108 -GAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 166

Query: 165 KILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWG 205
           K+L+ +  A            +H AAK  +   IE+ +++G
Sbjct: 167 KVLL-NAGAN-VNAAKLHETALHHAAKVKNVDLIEMLIEFG 205



 Score = 32.7 bits (71), Expect = 8.0
 Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 7/103 (6%)

Query: 4   IHLSTSTKVNLSFFV-----QAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARN 58
           + LS   KVN   +      +A  SG+  + +RL +   + L   D    T  H A AR 
Sbjct: 103 LSLSYGAKVNPPLYTASPLHEACMSGS-SECVRLLIDVGANLEAHDCHFGTPLHVACARE 161

Query: 59  NTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQ 101
           + + +  + N   ++NA      T LH A + + +D IE L++
Sbjct: 162 HLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLIE 203


>AF324892-1|AAK00336.1|  982|Homo sapiens myosin phosphatase target
           subunit 2 protein.
          Length = 982

 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GI-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AF324888-1|AAK00337.1|  982|Homo sapiens myosin phosphatase target
           subunit 2 protein.
          Length = 982

 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GI-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>AB003062-1|BAA28376.1|  982|Homo sapiens myosin phosphatase
           targeting/regulatory subunit protein.
          Length = 982

 Score = 72.9 bits (171), Expect = 6e-12
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 30/281 (10%)

Query: 229 SAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLT 288
           +A   GD   V   L  GA I+T   D  T +H AC    LD+VK +      E  A + 
Sbjct: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLV-----ENRANVN 118

Query: 289 SCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRA-GWRTVHTLI 347
             D +  TP+H AA   +  I  Y IN G+ +  ++ E   P  LA   A     +  + 
Sbjct: 119 QQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVK 178

Query: 348 RLGADI-QLKDINSRNVLH--LVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPL 404
           + G D+ Q +    + +L      +N G++ED                   +  +G + L
Sbjct: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDV-----------------RQARSGATAL 221

Query: 405 HYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINE 464
           H A+ +G+   L  LI+ G  +N+++ +  +PLH AA +G    AC +L        I  
Sbjct: 222 HVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG-VKEACSILAEALCDMDIRN 280

Query: 465 SDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPL 505
             G+  TP  +A  EG    + LL  +  +L  +   RN L
Sbjct: 281 KLGQ--TPFDVAD-EGLVEHLELLQKKQNVLRSEKETRNKL 318



 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 19/259 (7%)

Query: 17  FVQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAK 76
           F+ A  SG+ D+  +L L+  + +   +  G TA HQA    N +++ F+     ++N +
Sbjct: 62  FLAACSSGDTDEVRKL-LARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 77  DNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYK 136
           DN G TPLH A     L+  EY +       ++N + + P  +A E     +L    K +
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 137 SLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
            +       E  R       + D    A+  +     E  +   +G   +H AA    S 
Sbjct: 181 GI-----DLEQSRKEEEQQMLQD----ARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDL 256
            + + +Q G +        +++ D +G  PLH+A H G  +A  +   +   +  +    
Sbjct: 232 VLRLLIQAGYE--------LNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLG 283

Query: 257 STPVHLACAQGALDIVKLM 275
            TP  +A  +G ++ ++L+
Sbjct: 284 QTPFDVA-DEGLVEHLELL 301



 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 57/236 (24%), Positives = 93/236 (39%), Gaps = 20/236 (8%)

Query: 332 LLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
           L A S      V  L+  GADI   +++    LH   ++   L+      ++        
Sbjct: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDEN-LDMVKFLVENRAN----- 116

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQ 451
            +N++DN G +PLH A+  G++   E  I  GA + + N+  E P   A           
Sbjct: 117 -VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--- 172

Query: 452 LLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAA 509
           LL+  K         G  L        +   +     LN G +  + +  +G   LH+AA
Sbjct: 173 LLEQVK-------KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225

Query: 510 MSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
             GY++ + LL     + L+  D DG T LH A       + ++L    C +   N
Sbjct: 226 AKGYSEVLRLLIQA-GYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN 280


>BC030622-1|AAH30622.1|  301|Homo sapiens ankyrin repeat domain 29
           protein.
          Length = 301

 Score = 72.5 bits (170), Expect = 8e-12
 Identities = 83/284 (29%), Positives = 125/284 (44%), Gaps = 28/284 (9%)

Query: 293 QKMTPIHCAAMF----DHPEIVNYLINEGS-DINPLDKERRSPLLLAASRAGWRTVHTLI 347
           +K TP+  AA +     +  ++  L+N G  D++  D    + L++AA       V  L+
Sbjct: 7   KKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGR-----LEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
             GADI L+  +    L      G       L  F AS +             KD    +
Sbjct: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTE----------FRTKDEG--T 114

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
            L  AS+ GH++ +E L++ GA I+ +  +  + L  AA+ G       LL S      +
Sbjct: 115 ALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK---V 171

Query: 463 NESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHN-GRNPLHLAAMSGYTKTIELLH 521
           N+   +G  PL IAS+ GH+ VV ++L RGA      N G   L  AA  GY   I+ L 
Sbjct: 172 NQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL 231

Query: 522 SVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
                L   I K+G ++LH A +     ++ALLL  G   S  N
Sbjct: 232 KFSPTL--GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273



 Score = 56.4 bits (130), Expect = 6e-07
 Identities = 55/230 (23%), Positives = 95/230 (41%), Gaps = 10/230 (4%)

Query: 291 DVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLG 350
           D    T +  AA   H + V  L+ +G+DIN   +   + L  AA +     V  L   G
Sbjct: 43  DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFG 102

Query: 351 ADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASRE 410
           A  + +  +    L L     G ++      K          ++++   G + L  A++ 
Sbjct: 103 ASTEFRTKDEGTAL-LAASQYGHMQVVETLLKHGAN------IHDQLYDGATALFLAAQG 155

Query: 411 GHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGL 470
           G++  +  L+  GA +N    +  +PL  A++ G       +L         + +  +G 
Sbjct: 156 GYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADR---DAARNDGT 212

Query: 471 TPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELL 520
           T L  A+ +G+  V+  LL     L    NG + LH A +SG  KT+ LL
Sbjct: 213 TALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALL 262



 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 54/218 (24%), Positives = 94/218 (43%), Gaps = 15/218 (6%)

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           ++N   E G TAL FAA   H+   + L     A  +    +    +  A++    + +E
Sbjct: 71  DINLQRESGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDEGTALLAASQYGHMQVVE 129

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             L+ G       +Q   LYD  G   L  A  GG +  + L L SGAK++  + D + P
Sbjct: 130 TLLKHGAN---IHDQ---LYD--GATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAP 181

Query: 260 VHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSD 319
           + +A   G  ++V++M  ++  ++ A          T +  AA   + +++  L+     
Sbjct: 182 LWIASQMGHSEVVRVML-LRGADRDAARN----DGTTALLKAANKGYNDVIKELLKFSPT 236

Query: 320 INPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +  L K   S L  A      +TV  L+  GAD  L++
Sbjct: 237 LGIL-KNGTSALHAAVLSGNIKTVALLLEAGADPSLRN 273



 Score = 46.4 bits (105), Expect = 6e-04
 Identities = 54/256 (21%), Positives = 100/256 (39%), Gaps = 12/256 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  GN+     L  S    +  RD  G T    A+   + + +  +     D+N +  +
Sbjct: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
           G T L  A +    D + +L      T    +     +  A++   + V++   K+ +  
Sbjct: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGA-- 136

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
           N++     G TAL  AA   +    ++L+    A+  +P  +G  P+  A++   S  + 
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVR 195

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
           V L  G  R   R        N+G   L  A + G    ++  L+    +   ++  S  
Sbjct: 196 VMLLRGADRDAAR--------NDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSA- 246

Query: 260 VHLACAQGALDIVKLM 275
           +H A   G +  V L+
Sbjct: 247 LHAAVLSGNIKTVALL 262



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 55/242 (22%), Positives = 98/242 (40%), Gaps = 30/242 (12%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D+ G   L  A + G I  V   +  GA I+ Q+   +T +  A  QG  D+V+ +F   
Sbjct: 43  DSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFG 102

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              +          + T +  A+ + H ++V  L+  G++I+    +  + L LAA    
Sbjct: 103 ASTEFRTK-----DEGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGY 157

Query: 340 WRTVHTLIRLGADIQ------------LKDINSRNVLHLVVMNG---------GRLEDFA 378
              +  L+  GA +                +    V+ ++++ G         G      
Sbjct: 158 LDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLK 217

Query: 379 ASCKDHCE--KSLLQLLNEKD--NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNE 434
           A+ K + +  K LL+          G S LH A   G+I+++  L+  GA  +L+N  NE
Sbjct: 218 AANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANE 277

Query: 435 SP 436
            P
Sbjct: 278 LP 279



 Score = 44.0 bits (99), Expect = 0.003
 Identities = 52/254 (20%), Positives = 103/254 (40%), Gaps = 13/254 (5%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA +G++D    L L + + + ++   G TA   A+ + + +++ F+  +      +   
Sbjct: 53  AAYAGHIDCVRELVL-QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKD 111

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLF 139
             T L  A +   +  +E LL+               + +A +   + V+++     S  
Sbjct: 112 EGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLA--SGA 169

Query: 140 NVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIE 199
            VNQ  + G   L  A+   H    ++++    A+     N+G   + +AA    +  I+
Sbjct: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLR-GADRDAARNDGTTALLKAANKGYNDVIK 228

Query: 200 VFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTP 259
             L++    G  +          G   LH+AV  G+IK V L L +GA  S +      P
Sbjct: 229 ELLKFSPTLGILKN---------GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279

Query: 260 VHLACAQGALDIVK 273
             L   +  L +++
Sbjct: 280 AELTKNERILRLLR 293


>X61498-1|CAA43715.1|  933|Homo sapiens NF-kB subunit protein.
          Length = 933

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 480 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 539

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 540 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 599

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 600 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 659

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 660 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 697



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 483 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 539

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 540 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 599

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 600 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 659

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 660 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 697



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 476 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 534

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 535 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 592

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 593 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 652

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 653 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 704



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 476 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 535

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 536 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 590

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 591 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 646

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 647 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 704



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 479 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 538

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 539 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 584



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 477 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 536

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 537 GQTSVVSFLLRVG 549



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 633 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 692

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 693 IHAENEEPLCPL 704



 Score = 36.7 bits (81), Expect = 0.49
 Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 6/87 (6%)

Query: 40  LAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKDNAGNTPLHVAVENEAL 93
           L  +D  G T  H A     T+++    ++ ++A DL   N  ++   TPLH+AV     
Sbjct: 480 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 539

Query: 94  DAIEYLLQQHVETSVLNEKCQAPIHMA 120
             + +LL+   + ++L+    + +H+A
Sbjct: 540 SVVSFLLRVGADPALLDRHGDSAMHLA 566


>S76638-1|AAB21124.1|  900|Homo sapiens p50-NF-kappa B homolog
           protein.
          Length = 900

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 661 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 484 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 540

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 661 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 477 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 535

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 536 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 593

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 594 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 653

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 654 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 477 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 536

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 537 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 591

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 592 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 647

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 648 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 540 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 585



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 478 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 537

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 538 GQTSVVSFLLRVG 550



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 634 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 693

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 694 IHAENEEPLCPL 705



 Score = 37.1 bits (82), Expect = 0.37
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 6/103 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKD 77
           G   D   L   +   L  +D  G T  H A     T+++    ++ ++A DL   N  +
Sbjct: 465 GVTADRRALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTN 524

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           +   TPLH+AV       + +LL+   + ++L+    + +H+A
Sbjct: 525 HLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLA 567


>BT009769-1|AAP88771.1|  899|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 2 (p49/p100)
           protein.
          Length = 899

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 661 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 484 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 540

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 661 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 477 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 535

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 536 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 593

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 594 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 653

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 654 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 477 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 536

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 537 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 591

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 592 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 647

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 648 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 540 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 585



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 478 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 537

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 538 GQTSVVSFLLRVG 550



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 634 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 693

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 694 IHAENEEPLCPL 705



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 6/103 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKD 77
           G   D   L   +   L  +D  G T  H A     T+++    ++ ++A DL   N  +
Sbjct: 465 GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTN 524

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           +   TPLH+AV       + +LL+   + ++L+    + +H+A
Sbjct: 525 HLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLA 567


>BC002844-1|AAH02844.1|  899|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 2 (p49/p100)
           protein.
          Length = 899

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 661 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 484 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 540

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 661 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 477 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 535

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 536 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 593

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 594 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 653

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 654 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 477 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 536

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 537 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 591

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 592 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 647

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 648 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 540 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 585



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 478 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 537

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 538 GQTSVVSFLLRVG 550



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 634 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 693

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 694 IHAENEEPLCPL 705



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 6/103 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKD 77
           G   D   L   +   L  +D  G T  H A     T+++    ++ ++A DL   N  +
Sbjct: 465 GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTN 524

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           +   TPLH+AV       + +LL+   + ++L+    + +H+A
Sbjct: 525 HLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLA 567


>AY865619-1|AAW56071.1|  900|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 2 (p49/p100)
           protein.
          Length = 900

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 661 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 484 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 540

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 661 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 477 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 535

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 536 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 593

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 594 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 653

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 654 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 477 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 536

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 537 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 591

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 592 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 647

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 648 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 540 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 585



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 478 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 537

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 538 GQTSVVSFLLRVG 550



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 634 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 693

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 694 IHAENEEPLCPL 705



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 6/103 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKD 77
           G   D   L   +   L  +D  G T  H A     T+++    ++ ++A DL   N  +
Sbjct: 465 GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTN 524

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           +   TPLH+AV       + +LL+   + ++L+    + +H+A
Sbjct: 525 HLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLA 567


>AL121928-1|CAC08399.1|  900|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 2 (p49/p100)
           protein.
          Length = 900

 Score = 72.1 bits (169), Expect = 1e-11
 Identities = 57/220 (25%), Positives = 95/220 (43%), Gaps = 9/220 (4%)

Query: 287 LTSCDVQKMTPIHCAAMFDHPEIVN---YLINEGSD---INPLDKERRSPLLLAASRAGW 340
           LT+ D    TP+H A +     ++    Y+I+   D   +N  +   ++PL LA      
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 341 RTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTG 400
             V  L+R+GAD  L D +  + +HL +  G    +   +       ++ QLL+  D  G
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 401 CSPLHYASREGHIRSLENLIRLGACIN-LKNNNNESPLHFAARYGRFHTACQLLDSDKGT 459
             P+H A R      L+ L+  GA +   +     + LH A           L+   +  
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 460 FIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDH 499
             +N     G TPLH+A+  G+  +  LLL  GA +H ++
Sbjct: 661 --VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 58.8 bits (136), Expect = 1e-07
 Identities = 61/219 (27%), Positives = 93/219 (42%), Gaps = 13/219 (5%)

Query: 356 KDINSRNVLHLVVMNGGR--LEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHI 413
           +D N    LHL +++G    +E          +  ++ L N    T   PLH A   G  
Sbjct: 484 QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT---PLHLAVITGQT 540

Query: 414 RSLENLIRLGACINLKNNNNESPLHFAARYGRFHTAC--QLLDSDKGTF--IINESDGEG 469
             +  L+R+GA   L + + +S +H A R G         LL S       +++  D EG
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG 600

Query: 470 LTPLHIASREGHTRVVHLLLNRGALLHRDHN--GRNPLHLAA-MSGYTKTIELLHSVHSH 526
           L P+H+A R      + LL++ GA +       GR  LHLA  M        L+  + ++
Sbjct: 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN 660

Query: 527 LLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNN 565
           +  +    GNT LHLA     P+   LLL  G  +   N
Sbjct: 661 VNARTFA-GNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 698



 Score = 57.6 bits (133), Expect = 2e-07
 Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 12/236 (5%)

Query: 101 QQHVETSVLNEKCQAPIHMATELNKVSVLQ----VFAKYKSLFNVNQGGEHGRTALHFAA 156
           Q+H+ T+  +E    P+H+A    + SV++    V    + L  VN      +T LH A 
Sbjct: 477 QRHLLTAQ-DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAV 535

Query: 157 IHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMI 216
           I         L+  + A+      +G   +H A + A +   E+     +       Q++
Sbjct: 536 ITGQTSVVSFLLR-VGADPALLDRHGDSAMHLALR-AGAGAPELLRALLQSGAPAVPQLL 593

Query: 217 SLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKI-STQQHDLSTPVHLACAQGALDIVKLM 275
            + D EG  P+H AV     + ++L + SGA++ +T++    T +HLA     L +V  +
Sbjct: 594 HMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHL 653

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPL 331
            T    +  A + +      TP+H AA   +P +   L+  G+DI+  ++E   PL
Sbjct: 654 VT----KLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 57/240 (23%), Positives = 96/240 (40%), Gaps = 25/240 (10%)

Query: 212 REQMISLYDNEGNVPLHSAVHGGDIKAVELCL------RSGAKISTQQHDLSTPVHLACA 265
           +  +++  D  G+ PLH A+  G    +E  +      +    ++   H   TP+HLA  
Sbjct: 477 QRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVI 536

Query: 266 QGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLINEGSDINPL 323
            G   +V   F ++     A L   D    + +H A  A    PE++  L+  G+   P 
Sbjct: 537 TGQTSVVS--FLLRVGADPALL---DRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 591

Query: 324 -----DKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINS-RNVLHLVVMNGGRLEDF 377
                D E   P+ LA        +  L+  GA+++  +    R  LHL       +E+ 
Sbjct: 592 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLAT----EMEEL 647

Query: 378 AASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPL 437
                 H    L   +N +   G +PLH A+  G+      L++ GA I+ +N     PL
Sbjct: 648 GLVT--HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 705



 Score = 43.6 bits (98), Expect = 0.004
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 461 IINESDGEGLTPLHIASREGHTRVV-------HLLLNRGALLHRDHNGRNPLHLAAMSGY 513
           ++   D  G TPLH+A   G T V+       H   + G +   +H  + PLHLA ++G 
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539

Query: 514 TKTIELLHSVHSHLLDQIDKDGNTSLHLATM--ENKPSSIALLLSMG 558
           T  +  L  V +     +D+ G++++HLA       P  +  LL  G
Sbjct: 540 TSVVSFLLRVGADPA-LLDRHGDSAMHLALRAGAGAPELLRALLQSG 585



 Score = 39.5 bits (88), Expect = 0.069
 Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 5/73 (6%)

Query: 491 RGALLHRDHNGRNPLHLAAMSGYTKTIELLHSV--HSHLLDQIDKDGN---TSLHLATME 545
           R  L  +D NG  PLHLA + G T  IE +  V  H+  L  ++   +   T LHLA + 
Sbjct: 478 RHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVIT 537

Query: 546 NKPSSIALLLSMG 558
            + S ++ LL +G
Sbjct: 538 GQTSVVSFLLRVG 550



 Score = 38.7 bits (86), Expect = 0.12
 Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 47  GRTAAHQASARNNTNIL-HFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVE 105
           GRTA H A+      ++ H +     ++NA+  AGNTPLH+A           LL+   +
Sbjct: 634 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 693

Query: 106 TSVLNEKCQAPI 117
               NE+   P+
Sbjct: 694 IHAENEEPLCPL 705



 Score = 37.5 bits (83), Expect = 0.28
 Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 6/103 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILH---FINNYAGDL---NAKD 77
           G   D   L   +   L  +D  G T  H A     T+++    ++ ++A DL   N  +
Sbjct: 465 GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTN 524

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           +   TPLH+AV       + +LL+   + ++L+    + +H+A
Sbjct: 525 HLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLA 567


>BC101620-1|AAI01621.1| 1001|Homo sapiens ankyrin repeat domain 35
           protein.
          Length = 1001

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 50/151 (33%), Positives = 76/151 (50%), Gaps = 5/151 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N K+  G + LH A+     + ++ L++ GA  +  +  N SPLH+AA  G   +   L
Sbjct: 80  INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
            D +     ++  D +G TPL IAS  GH  +   LL RGA ++  D N ++ L LA   
Sbjct: 140 CDHEA---FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           G  +  ELL S H      +D  G+ +LH A
Sbjct: 197 GSAEVAELLLS-HGADAGAVDSTGHDALHYA 226



 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 53/162 (32%), Positives = 79/162 (48%), Gaps = 6/162 (3%)

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           ++N +SP H AA  G   T C  +    G  I N  + +G T LH+A+     + V +LL
Sbjct: 51  DSNGQSPFHLAASKGL--TECLTILLANGADI-NSKNEDGSTALHLATISCQPQCVKVLL 107

Query: 490 NRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA     D   R+PLH AA SG   ++ LL   H   LD +D DG T L +A++    
Sbjct: 108 QHGANEDAVDAENRSPLHWAASSGCASSVLLLCD-HEAFLDVLDNDGRTPLMIASLGGHA 166

Query: 549 SSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPEAALAMVTH 589
           +  + LL  G R++  +  D SA+  A      E A  +++H
Sbjct: 167 AICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSH 208



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 57/237 (24%), Positives = 96/237 (40%), Gaps = 16/237 (6%)

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEWKKPCNNGYYPIHE 188
           ++F+   +   V +   H +  L   A+H  D+     L +   A   K  +NG  P H 
Sbjct: 3   RIFSCSSTQVAVERWNRHDQKLLE--AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA    +  + + L  G          I+  + +G+  LH A      + V++ L+ GA 
Sbjct: 61  AASKGLTECLTILLANGAD--------INSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
                 +  +P+H A + G    V L+      +  A L   D    TP+  A++  H  
Sbjct: 113 EDAVDAENRSPLHWAASSGCASSVLLLC-----DHEAFLDVLDNDGRTPLMIASLGGHAA 167

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           I + L+  G+ +N  DK  +S L+LA  +        L+  GAD    D    + LH
Sbjct: 168 ICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 57/194 (29%), Positives = 84/194 (43%), Gaps = 10/194 (5%)

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
           K A  T  D    +P H AA     E +  L+  G+DIN  +++  + L LA      + 
Sbjct: 43  KSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQC 102

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           V  L++ GA+    D  +R+ LH    + G        C DH  ++ L +L   DN G +
Sbjct: 103 VKVLLQHGANEDAVDAENRSPLHWAA-SSGCASSVLLLC-DH--EAFLDVL---DNDGRT 155

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           PL  AS  GH      L++ GA +N+ + N++S L  A   G    A  LL        +
Sbjct: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215

Query: 463 NESDGEGLTPLHIA 476
              D  G   LH A
Sbjct: 216 ---DSTGHDALHYA 226



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/219 (22%), Positives = 94/219 (42%), Gaps = 13/219 (5%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++A   G+V     L   + +R    D  G++  H A+++  T  L  +     D+N+K+
Sbjct: 25  LEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKN 84

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+T LH+A  +     ++ LLQ       ++ + ++P+H A      S + +   +++
Sbjct: 85  EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144

Query: 138 LFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
             +V      GRT L  A++  H  +C+++L     A       N    +  A +  S+ 
Sbjct: 145 FLDVLD--NDGRTPLMIASLGGHAAICSQLL--QRGARVNVTDKNDKSALILACEKGSAE 200

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGD 235
             E+ L  G   G          D+ G+  LH A+H  D
Sbjct: 201 VAELLLSHGADAGAV--------DSTGHDALHYALHTQD 231


>BC101618-1|AAI01619.1| 1001|Homo sapiens ankyrin repeat domain 35
           protein.
          Length = 1001

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 50/151 (33%), Positives = 76/151 (50%), Gaps = 5/151 (3%)

Query: 393 LNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQL 452
           +N K+  G + LH A+     + ++ L++ GA  +  +  N SPLH+AA  G   +   L
Sbjct: 80  INSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLL 139

Query: 453 LDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMS 511
            D +     ++  D +G TPL IAS  GH  +   LL RGA ++  D N ++ L LA   
Sbjct: 140 CDHEA---FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196

Query: 512 GYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           G  +  ELL S H      +D  G+ +LH A
Sbjct: 197 GSAEVAELLLS-HGADAGAVDSTGHDALHYA 226



 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 53/162 (32%), Positives = 79/162 (48%), Gaps = 6/162 (3%)

Query: 430 NNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLL 489
           ++N +SP H AA  G   T C  +    G  I N  + +G T LH+A+     + V +LL
Sbjct: 51  DSNGQSPFHLAASKGL--TECLTILLANGADI-NSKNEDGSTALHLATISCQPQCVKVLL 107

Query: 490 NRGALLHR-DHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKP 548
             GA     D   R+PLH AA SG   ++ LL   H   LD +D DG T L +A++    
Sbjct: 108 QHGANEDAVDAENRSPLHWAASSGCASSVLLLCD-HEAFLDVLDNDGRTPLMIASLGGHA 166

Query: 549 SSIALLLSMGCRLSYNNM-DMSAIDYAIYYKFPEAALAMVTH 589
           +  + LL  G R++  +  D SA+  A      E A  +++H
Sbjct: 167 AICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSH 208



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 57/237 (24%), Positives = 96/237 (40%), Gaps = 16/237 (6%)

Query: 130 QVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLC-AKILITDLDAEWKKPCNNGYYPIHE 188
           ++F+   +   V +   H +  L   A+H  D+     L +   A   K  +NG  P H 
Sbjct: 3   RIFSCSSTQVAVERWNRHDQKLLE--AVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60

Query: 189 AAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAK 248
           AA    +  + + L  G          I+  + +G+  LH A      + V++ L+ GA 
Sbjct: 61  AASKGLTECLTILLANGAD--------INSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112

Query: 249 ISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPE 308
                 +  +P+H A + G    V L+      +  A L   D    TP+  A++  H  
Sbjct: 113 EDAVDAENRSPLHWAASSGCASSVLLLC-----DHEAFLDVLDNDGRTPLMIASLGGHAA 167

Query: 309 IVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLH 365
           I + L+  G+ +N  DK  +S L+LA  +        L+  GAD    D    + LH
Sbjct: 168 ICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224



 Score = 63.3 bits (147), Expect = 5e-09
 Identities = 57/194 (29%), Positives = 84/194 (43%), Gaps = 10/194 (5%)

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
           K A  T  D    +P H AA     E +  L+  G+DIN  +++  + L LA      + 
Sbjct: 43  KSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQC 102

Query: 343 VHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCS 402
           V  L++ GA+    D  +R+ LH    + G        C DH  ++ L +L   DN G +
Sbjct: 103 VKVLLQHGANEDAVDAENRSPLHWAA-SSGCASSVLLLC-DH--EAFLDVL---DNDGRT 155

Query: 403 PLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFII 462
           PL  AS  GH      L++ GA +N+ + N++S L  A   G    A  LL        +
Sbjct: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215

Query: 463 NESDGEGLTPLHIA 476
              D  G   LH A
Sbjct: 216 ---DSTGHDALHYA 226



 Score = 59.3 bits (137), Expect = 8e-08
 Identities = 50/219 (22%), Positives = 94/219 (42%), Gaps = 13/219 (5%)

Query: 18  VQAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKD 77
           ++A   G+V     L   + +R    D  G++  H A+++  T  L  +     D+N+K+
Sbjct: 25  LEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKN 84

Query: 78  NAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKS 137
             G+T LH+A  +     ++ LLQ       ++ + ++P+H A      S + +   +++
Sbjct: 85  EDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEA 144

Query: 138 LFNVNQGGEHGRTALHFAAIHDH-DLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSR 196
             +V      GRT L  A++  H  +C+++L     A       N    +  A +  S+ 
Sbjct: 145 FLDVLD--NDGRTPLMIASLGGHAAICSQLL--QRGARVNVTDKNDKSALILACEKGSAE 200

Query: 197 TIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGD 235
             E+ L  G   G          D+ G+  LH A+H  D
Sbjct: 201 VAELLLSHGADAGAV--------DSTGHDALHYALHTQD 231


>M58603-1|AAA36360.1|  968|Homo sapiens nuclear factor kappa-B DNA
           binding subunit protein.
          Length = 968

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H   + D  E+ + LI++   IN  +   ++PL LA        V  L+R GAD+ L D
Sbjct: 554 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLD 612

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
               +VLHL    G    D   S     +K+ L LL+  +  G + +H A     +  L 
Sbjct: 613 RLGNSVLHLAAKEG---HDKVLSILLKHKKAAL-LLDHPNGDGLNAIHLAMMSNSLPCLL 668

Query: 418 NLIRLGACINL-KNNNNESPLHFAARYGRFHTA-CQLLDSDKGTFIINESDGEGLTPLHI 475
            L+  GA +N  +  +  + LH A  +     A C LL+ D     ++ +  +G TPLHI
Sbjct: 669 LLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAH---VDSTTYDGTTPLHI 725

Query: 476 ASREGHTRVVHLLLNRGA 493
           A+  G TR+  LL   GA
Sbjct: 726 AAGRGSTRLAALLKAAGA 743



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 7/208 (3%)

Query: 355 LKDINSRNVLHLVV--MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           ++D N  +VLHL +  ++   + D            ++ + N+   T   PLH A     
Sbjct: 538 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT---PLHLAVITKQ 594

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +E+L+R GA ++L +    S LH AA+ G       LL   K   +++  +G+GL  
Sbjct: 595 EDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 654

Query: 473 LHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           +H+A        + LL+  GA ++     +GR  LHLA           L       +D 
Sbjct: 655 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 714

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMG 558
              DG T LH+A         ALL + G
Sbjct: 715 TTYDGTTPLHIAAGRGSTRLAALLKAAG 742



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 52/217 (23%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 41  AVRDGRGRTAAHQASARNNT----NILHFINNYAGD--LNAKDNAGNTPLHVAVENEALD 94
           AV+D  G +  H A    ++    ++L   +    D  +N +++   TPLH+AV  +  D
Sbjct: 537 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 596

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALH 153
            +E LL+   + S+L+    + +H+A +     VL +  K+ K+   ++     G  A+H
Sbjct: 597 VVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIH 656

Query: 154 FAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            A + +   C  +L+    D++A+ +K   +G   +H A ++ +       L  G+    
Sbjct: 657 LAMMSNSLPCLLLLVAAGADVNAQEQK---SGRTALHLAVEHDNISLAGCLLLEGDAHVD 713

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +     + YD  G  PLH A   G  +   L   +GA
Sbjct: 714 S-----TTYD--GTTPLHIAAGRGSTRLAALLKAAGA 743



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 43/195 (22%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH  +  + L+    L+   +  ++ N+  Q P+H+A    +  V++   +  +  +++ 
Sbjct: 554 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGA--DLSL 610

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRTIEVF 201
               G + LH AA   HD    IL+    A      P  +G   IH A  + S   + + 
Sbjct: 611 LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLL 670

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           +  G       ++        G   LH AV   +I      L  G A + +  +D +TP+
Sbjct: 671 VAAGADVNAQEQK-------SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 723

Query: 261 HLACAQGALDIVKLM 275
           H+A  +G+  +  L+
Sbjct: 724 HIAAGRGSTRLAALL 738



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 45/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
           NG   +H A  +  S+ +   L+     G   + +I++ ++    PLH AV       VE
Sbjct: 542 NGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 599

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             LR+GA +S      ++ +HLA  +G   ++ ++  ++ K+    L   +   +  IH 
Sbjct: 600 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL--LKHKKAALLLDHPNGDGLNAIHL 657

Query: 301 AAMFDHPEIVNYLINEGSDINPLD-KERRSPLLLAASRAGWRTVHTLIRLG-ADIQLKDI 358
           A M +    +  L+  G+D+N  + K  R+ L LA           L+  G A +     
Sbjct: 658 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 717

Query: 359 NSRNVLHLVVMNG 371
           +    LH+    G
Sbjct: 718 DGTTPLHIAAGRG 730



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H A +    ++V  L+  G+D++ LD+   S L LAA     + +  L++      L
Sbjct: 584 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 643

Query: 356 KDI---NSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            D    +  N +HL +M+       +  C      +   +  ++  +G + LH A    +
Sbjct: 644 LDHPNGDGLNAIHLAMMSN------SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 697

Query: 413 IRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHTACQL 452
           I     L+  G A ++    +  +PLH AA  G    A  L
Sbjct: 698 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 738


>M55643-1|AAA36361.1|  969|Homo sapiens factor KBF1 protein.
          Length = 969

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H   + D  E+ + LI++   IN  +   ++PL LA        V  L+R GAD+ L D
Sbjct: 555 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLD 613

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
               +VLHL    G    D   S     +K+ L LL+  +  G + +H A     +  L 
Sbjct: 614 RLGNSVLHLAAKEG---HDKVLSILLKHKKAAL-LLDHPNGDGLNAIHLAMMSNSLPCLL 669

Query: 418 NLIRLGACINL-KNNNNESPLHFAARYGRFHTA-CQLLDSDKGTFIINESDGEGLTPLHI 475
            L+  GA +N  +  +  + LH A  +     A C LL+ D     ++ +  +G TPLHI
Sbjct: 670 LLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAH---VDSTTYDGTTPLHI 726

Query: 476 ASREGHTRVVHLLLNRGA 493
           A+  G TR+  LL   GA
Sbjct: 727 AAGRGSTRLAALLKAAGA 744



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 7/208 (3%)

Query: 355 LKDINSRNVLHLVV--MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           ++D N  +VLHL +  ++   + D            ++ + N+   T   PLH A     
Sbjct: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT---PLHLAVITKQ 595

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +E+L+R GA ++L +    S LH AA+ G       LL   K   +++  +G+GL  
Sbjct: 596 EDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 655

Query: 473 LHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           +H+A        + LL+  GA ++     +GR  LHLA           L       +D 
Sbjct: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 715

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMG 558
              DG T LH+A         ALL + G
Sbjct: 716 TTYDGTTPLHIAAGRGSTRLAALLKAAG 743



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 52/217 (23%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 41  AVRDGRGRTAAHQASARNNT----NILHFINNYAGD--LNAKDNAGNTPLHVAVENEALD 94
           AV+D  G +  H A    ++    ++L   +    D  +N +++   TPLH+AV  +  D
Sbjct: 538 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 597

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALH 153
            +E LL+   + S+L+    + +H+A +     VL +  K+ K+   ++     G  A+H
Sbjct: 598 VVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIH 657

Query: 154 FAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            A + +   C  +L+    D++A+ +K   +G   +H A ++ +       L  G+    
Sbjct: 658 LAMMSNSLPCLLLLVAAGADVNAQEQK---SGRTALHLAVEHDNISLAGCLLLEGDAHVD 714

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +     + YD  G  PLH A   G  +   L   +GA
Sbjct: 715 S-----TTYD--GTTPLHIAAGRGSTRLAALLKAAGA 744



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 43/195 (22%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH  +  + L+    L+   +  ++ N+  Q P+H+A    +  V++   +  +  +++ 
Sbjct: 555 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGA--DLSL 611

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRTIEVF 201
               G + LH AA   HD    IL+    A      P  +G   IH A  + S   + + 
Sbjct: 612 LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLL 671

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           +  G       ++        G   LH AV   +I      L  G A + +  +D +TP+
Sbjct: 672 VAAGADVNAQEQK-------SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 724

Query: 261 HLACAQGALDIVKLM 275
           H+A  +G+  +  L+
Sbjct: 725 HIAAGRGSTRLAALL 739



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 45/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
           NG   +H A  +  S+ +   L+     G   + +I++ ++    PLH AV       VE
Sbjct: 543 NGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             LR+GA +S      ++ +HLA  +G   ++ ++  ++ K+    L   +   +  IH 
Sbjct: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL--LKHKKAALLLDHPNGDGLNAIHL 658

Query: 301 AAMFDHPEIVNYLINEGSDINPLD-KERRSPLLLAASRAGWRTVHTLIRLG-ADIQLKDI 358
           A M +    +  L+  G+D+N  + K  R+ L LA           L+  G A +     
Sbjct: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718

Query: 359 NSRNVLHLVVMNG 371
           +    LH+    G
Sbjct: 719 DGTTPLHIAAGRG 731



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H A +    ++V  L+  G+D++ LD+   S L LAA     + +  L++      L
Sbjct: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644

Query: 356 KDI---NSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            D    +  N +HL +M+       +  C      +   +  ++  +G + LH A    +
Sbjct: 645 LDHPNGDGLNAIHLAMMSN------SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698

Query: 413 IRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHTACQL 452
           I     L+  G A ++    +  +PLH AA  G    A  L
Sbjct: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 739


>BC051765-1|AAH51765.1|  969|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 1 (p105)
           protein.
          Length = 969

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H   + D  E+ + LI++   IN  +   ++PL LA        V  L+R GAD+ L D
Sbjct: 555 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLD 613

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
               +VLHL    G    D   S     +K+ L LL+  +  G + +H A     +  L 
Sbjct: 614 RLGNSVLHLAAKEG---HDKVLSILLKHKKAAL-LLDHPNGDGLNAIHLAMMSNSLPCLL 669

Query: 418 NLIRLGACINL-KNNNNESPLHFAARYGRFHTA-CQLLDSDKGTFIINESDGEGLTPLHI 475
            L+  GA +N  +  +  + LH A  +     A C LL+ D     ++ +  +G TPLHI
Sbjct: 670 LLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAH---VDSTTYDGTTPLHI 726

Query: 476 ASREGHTRVVHLLLNRGA 493
           A+  G TR+  LL   GA
Sbjct: 727 AAGRGSTRLAALLKAAGA 744



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 7/208 (3%)

Query: 355 LKDINSRNVLHLVV--MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           ++D N  +VLHL +  ++   + D            ++ + N+   T   PLH A     
Sbjct: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT---PLHLAVITKQ 595

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +E+L+R GA ++L +    S LH AA+ G       LL   K   +++  +G+GL  
Sbjct: 596 EDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 655

Query: 473 LHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           +H+A        + LL+  GA ++     +GR  LHLA           L       +D 
Sbjct: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 715

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMG 558
              DG T LH+A         ALL + G
Sbjct: 716 TTYDGTTPLHIAAGRGSTRLAALLKAAG 743



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 52/217 (23%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 41  AVRDGRGRTAAHQASARNNT----NILHFINNYAGD--LNAKDNAGNTPLHVAVENEALD 94
           AV+D  G +  H A    ++    ++L   +    D  +N +++   TPLH+AV  +  D
Sbjct: 538 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 597

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALH 153
            +E LL+   + S+L+    + +H+A +     VL +  K+ K+   ++     G  A+H
Sbjct: 598 VVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIH 657

Query: 154 FAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            A + +   C  +L+    D++A+ +K   +G   +H A ++ +       L  G+    
Sbjct: 658 LAMMSNSLPCLLLLVAAGADVNAQEQK---SGRTALHLAVEHDNISLAGCLLLEGDAHVD 714

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +     + YD  G  PLH A   G  +   L   +GA
Sbjct: 715 S-----TTYD--GTTPLHIAAGRGSTRLAALLKAAGA 744



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 43/195 (22%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH  +  + L+    L+   +  ++ N+  Q P+H+A    +  V++   +  +  +++ 
Sbjct: 555 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGA--DLSL 611

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRTIEVF 201
               G + LH AA   HD    IL+    A      P  +G   IH A  + S   + + 
Sbjct: 612 LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLL 671

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           +  G       ++        G   LH AV   +I      L  G A + +  +D +TP+
Sbjct: 672 VAAGADVNAQEQK-------SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 724

Query: 261 HLACAQGALDIVKLM 275
           H+A  +G+  +  L+
Sbjct: 725 HIAAGRGSTRLAALL 739



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 45/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
           NG   +H A  +  S+ +   L+     G   + +I++ ++    PLH AV       VE
Sbjct: 543 NGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             LR+GA +S      ++ +HLA  +G   ++ ++  ++ K+    L   +   +  IH 
Sbjct: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL--LKHKKAALLLDHPNGDGLNAIHL 658

Query: 301 AAMFDHPEIVNYLINEGSDINPLD-KERRSPLLLAASRAGWRTVHTLIRLG-ADIQLKDI 358
           A M +    +  L+  G+D+N  + K  R+ L LA           L+  G A +     
Sbjct: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718

Query: 359 NSRNVLHLVVMNG 371
           +    LH+    G
Sbjct: 719 DGTTPLHIAAGRG 731



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H A +    ++V  L+  G+D++ LD+   S L LAA     + +  L++      L
Sbjct: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644

Query: 356 KDI---NSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            D    +  N +HL +M+       +  C      +   +  ++  +G + LH A    +
Sbjct: 645 LDHPNGDGLNAIHLAMMSN------SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698

Query: 413 IRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHTACQL 452
           I     L+  G A ++    +  +PLH AA  G    A  L
Sbjct: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 739


>BC037542-1|AAH37542.1|  999|Homo sapiens MIB2 protein protein.
          Length = 999

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 136/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 516 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 574

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVS--VLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A      +  +++V  +  +
Sbjct: 575 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPN 634

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 635 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 693

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 694 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 746

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 747 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 804

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 805 ADVSYTNHRGRSPLDLAA 822



 Score = 67.3 bits (157), Expect = 3e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 594

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 595 C-----ERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLH 649

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 650 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 704

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 705 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 763

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 764 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 822

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 823 EGRVLKALQ 831



 Score = 56.4 bits (130), Expect = 6e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 491 RALGLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 549

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 550 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 594



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 51/255 (20%), Positives = 99/255 (38%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 487 GNAARALGLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 545

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 546 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 603

Query: 144 GGEHGRTALHFA--AIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A  A        ++L    + +     + G+  +H A+    +  +   
Sbjct: 604 PDAHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 663

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 664 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 716

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 717 HLAVQQAHVGLVPLL 731



 Score = 54.0 bits (124), Expect = 3e-06
 Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 507 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 566

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G  
Sbjct: 567 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAG 623

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 624 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 740

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 741 EDEEGDTALHVALQRHQLLPLVADGAG 767



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 44/179 (24%), Positives = 78/179 (43%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 539 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 596

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G   +V +L     +     +  G   LH A++ G
Sbjct: 597 RGCDV-NLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 655

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 656 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 714


>BC033210-1|AAH33210.1|  550|Homo sapiens NFKB1 protein protein.
          Length = 550

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H   + D  E+ + LI++   IN  +   ++PL LA        V  L+R GAD+ L D
Sbjct: 136 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLD 194

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
               +VLHL    G    D   S     +K+ L LL+  +  G + +H A     +  L 
Sbjct: 195 RLGNSVLHLAAKEG---HDKVLSILLKHKKAAL-LLDHPNGDGLNAIHLAMMSNSLPCLL 250

Query: 418 NLIRLGACINL-KNNNNESPLHFAARYGRFHTA-CQLLDSDKGTFIINESDGEGLTPLHI 475
            L+  GA +N  +  +  + LH A  +     A C LL+ D     ++ +  +G TPLHI
Sbjct: 251 LLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAH---VDSTTYDGTTPLHI 307

Query: 476 ASREGHTRVVHLLLNRGA 493
           A+  G TR+  LL   GA
Sbjct: 308 AAGRGSTRLAALLKAAGA 325



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 7/208 (3%)

Query: 355 LKDINSRNVLHLVV--MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           ++D N  +VLHL +  ++   + D            ++ + N+   T   PLH A     
Sbjct: 120 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT---PLHLAVITKQ 176

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +E+L+R GA ++L +    S LH AA+ G       LL   K   +++  +G+GL  
Sbjct: 177 EDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 236

Query: 473 LHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           +H+A        + LL+  GA ++     +GR  LHLA           L       +D 
Sbjct: 237 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 296

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMG 558
              DG T LH+A         ALL + G
Sbjct: 297 TTYDGTTPLHIAAGRGSTRLAALLKAAG 324



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 52/217 (23%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 41  AVRDGRGRTAAHQASARNNT----NILHFINNYAGD--LNAKDNAGNTPLHVAVENEALD 94
           AV+D  G +  H A    ++    ++L   +    D  +N +++   TPLH+AV  +  D
Sbjct: 119 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 178

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALH 153
            +E LL+   + S+L+    + +H+A +     VL +  K+ K+   ++     G  A+H
Sbjct: 179 VVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIH 238

Query: 154 FAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            A + +   C  +L+    D++A+ +K   +G   +H A ++ +       L  G+    
Sbjct: 239 LAMMSNSLPCLLLLVAAGADVNAQEQK---SGRTALHLAVEHDNISLAGCLLLEGDAHVD 295

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +     + YD  G  PLH A   G  +   L   +GA
Sbjct: 296 S-----TTYD--GTTPLHIAAGRGSTRLAALLKAAGA 325



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 43/195 (22%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH  +  + L+    L+   +  ++ N+  Q P+H+A    +  V++   +  +  +++ 
Sbjct: 136 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGA--DLSL 192

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRTIEVF 201
               G + LH AA   HD    IL+    A      P  +G   IH A  + S   + + 
Sbjct: 193 LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLL 252

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           +  G       ++        G   LH AV   +I      L  G A + +  +D +TP+
Sbjct: 253 VAAGADVNAQEQK-------SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 305

Query: 261 HLACAQGALDIVKLM 275
           H+A  +G+  +  L+
Sbjct: 306 HIAAGRGSTRLAALL 320



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 45/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
           NG   +H A  +  S+ +   L+     G   + +I++ ++    PLH AV       VE
Sbjct: 124 NGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 181

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             LR+GA +S      ++ +HLA  +G   ++ ++  ++ K+    L   +   +  IH 
Sbjct: 182 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL--LKHKKAALLLDHPNGDGLNAIHL 239

Query: 301 AAMFDHPEIVNYLINEGSDINPLD-KERRSPLLLAASRAGWRTVHTLIRLG-ADIQLKDI 358
           A M +    +  L+  G+D+N  + K  R+ L LA           L+  G A +     
Sbjct: 240 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 299

Query: 359 NSRNVLHLVVMNG 371
           +    LH+    G
Sbjct: 300 DGTTPLHIAAGRG 312



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H A +    ++V  L+  G+D++ LD+   S L LAA     + +  L++      L
Sbjct: 166 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 225

Query: 356 KDI---NSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            D    +  N +HL +M+       +  C      +   +  ++  +G + LH A    +
Sbjct: 226 LDHPNGDGLNAIHLAMMSN------SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 279

Query: 413 IRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHTACQL 452
           I     L+  G A ++    +  +PLH AA  G    A  L
Sbjct: 280 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 320


>BC016490-1|AAH16490.1| 1030|Homo sapiens MIB2 protein protein.
          Length = 1030

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 547 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 605

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 606 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 665

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 666 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 724

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 725 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 777

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 778 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 835

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 836 ADVSYTNHRGRSPLDLAA 853



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 566 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 625

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 626 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 680

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 681 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 735

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 736 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 794

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 795 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 853

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 854 EGRVLKALQ 862



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 522 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 580

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 581 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 625



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 518 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 576

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 577 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 634

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 635 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 694

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 695 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 747

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 748 HLAVQQAHVGLVPLL 762



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 538 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 597

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 598 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 654

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 655 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 714

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 715 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 771

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 772 EDEEGDTALHVALQRHQLLPLVADGAG 798



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 570 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 627

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 628 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 686

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 687 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 745


>AY223820-1|AAO30127.1|  968|Homo sapiens nuclear factor of kappa
           light polypeptide gene enhancer in B-cells 1 (p105)
           protein.
          Length = 968

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 298 IHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKD 357
           +H   + D  E+ + LI++   IN  +   ++PL LA        V  L+R GAD+ L D
Sbjct: 554 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLD 612

Query: 358 INSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLE 417
               +VLHL    G    D   S     +K+ L LL+  +  G + +H A     +  L 
Sbjct: 613 RLGNSVLHLAAKEG---HDKVLSILLKHKKAAL-LLDHPNGDGLNAIHLAMMSNSLPCLL 668

Query: 418 NLIRLGACINL-KNNNNESPLHFAARYGRFHTA-CQLLDSDKGTFIINESDGEGLTPLHI 475
            L+  GA +N  +  +  + LH A  +     A C LL+ D     ++ +  +G TPLHI
Sbjct: 669 LLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAH---VDSTTYDGTTPLHI 725

Query: 476 ASREGHTRVVHLLLNRGA 493
           A+  G TR+  LL   GA
Sbjct: 726 AAGRGSTRLAALLKAAGA 743



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 88/208 (42%), Gaps = 7/208 (3%)

Query: 355 LKDINSRNVLHLVV--MNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
           ++D N  +VLHL +  ++   + D            ++ + N+   T   PLH A     
Sbjct: 538 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT---PLHLAVITKQ 594

Query: 413 IRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTP 472
              +E+L+R GA ++L +    S LH AA+ G       LL   K   +++  +G+GL  
Sbjct: 595 EDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 654

Query: 473 LHIASREGHTRVVHLLLNRGALLH--RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQ 530
           +H+A        + LL+  GA ++     +GR  LHLA           L       +D 
Sbjct: 655 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 714

Query: 531 IDKDGNTSLHLATMENKPSSIALLLSMG 558
              DG T LH+A         ALL + G
Sbjct: 715 TTYDGTTPLHIAAGRGSTRLAALLKAAG 742



 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 52/217 (23%), Positives = 98/217 (45%), Gaps = 20/217 (9%)

Query: 41  AVRDGRGRTAAHQASARNNT----NILHFINNYAGD--LNAKDNAGNTPLHVAVENEALD 94
           AV+D  G +  H A    ++    ++L   +    D  +N +++   TPLH+AV  +  D
Sbjct: 537 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 596

Query: 95  AIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKY-KSLFNVNQGGEHGRTALH 153
            +E LL+   + S+L+    + +H+A +     VL +  K+ K+   ++     G  A+H
Sbjct: 597 VVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIH 656

Query: 154 FAAIHDHDLCAKILI---TDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGC 210
            A + +   C  +L+    D++A+ +K   +G   +H A ++ +       L  G+    
Sbjct: 657 LAMMSNSLPCLLLLVAAGADVNAQEQK---SGRTALHLAVEHDNISLAGCLLLEGDAHVD 713

Query: 211 TREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGA 247
           +     + YD  G  PLH A   G  +   L   +GA
Sbjct: 714 S-----TTYD--GTTPLHIAAGRGSTRLAALLKAAGA 743



 Score = 44.4 bits (100), Expect = 0.002
 Identities = 43/195 (22%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH  +  + L+    L+   +  ++ N+  Q P+H+A    +  V++   +  +  +++ 
Sbjct: 554 LHSQLVRDLLEVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGA--DLSL 610

Query: 144 GGEHGRTALHFAAIHDHDLCAKILITDLDAEW--KKPCNNGYYPIHEAAKNASSRTIEVF 201
               G + LH AA   HD    IL+    A      P  +G   IH A  + S   + + 
Sbjct: 611 LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLL 670

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           +  G       ++        G   LH AV   +I      L  G A + +  +D +TP+
Sbjct: 671 VAAGADVNAQEQK-------SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 723

Query: 261 HLACAQGALDIVKLM 275
           H+A  +G+  +  L+
Sbjct: 724 HIAAGRGSTRLAALL 738



 Score = 42.3 bits (95), Expect = 0.010
 Identities = 45/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)

Query: 181 NGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVE 240
           NG   +H A  +  S+ +   L+     G   + +I++ ++    PLH AV       VE
Sbjct: 542 NGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 599

Query: 241 LCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHC 300
             LR+GA +S      ++ +HLA  +G   ++ ++  ++ K+    L   +   +  IH 
Sbjct: 600 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL--LKHKKAALLLDHPNGDGLNAIHL 657

Query: 301 AAMFDHPEIVNYLINEGSDINPLD-KERRSPLLLAASRAGWRTVHTLIRLG-ADIQLKDI 358
           A M +    +  L+  G+D+N  + K  R+ L LA           L+  G A +     
Sbjct: 658 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 717

Query: 359 NSRNVLHLVVMNG 371
           +    LH+    G
Sbjct: 718 DGTTPLHIAAGRG 730



 Score = 38.3 bits (85), Expect = 0.16
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 296 TPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQL 355
           TP+H A +    ++V  L+  G+D++ LD+   S L LAA     + +  L++      L
Sbjct: 584 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 643

Query: 356 KDI---NSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGH 412
            D    +  N +HL +M+       +  C      +   +  ++  +G + LH A    +
Sbjct: 644 LDHPNGDGLNAIHLAMMSN------SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 697

Query: 413 IRSLENLIRLG-ACINLKNNNNESPLHFAARYGRFHTACQL 452
           I     L+  G A ++    +  +PLH AA  G    A  L
Sbjct: 698 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 738


>AL691432-4|CAM12833.1|  919|Homo sapiens mindbomb homolog 2
           (Drosophila) protein.
          Length = 919

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 436 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 494

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 495 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 554

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 555 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 613

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 614 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 666

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 667 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 724

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 725 ADVSYTNHRGRSPLDLAA 742



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 455 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 514

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 515 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 569

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 570 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 624

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 625 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 683

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 684 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 742

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 743 EGRVLKALQ 751



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 411 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 469

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 470 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 514



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 407 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 465

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 466 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 523

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 524 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 583

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 584 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 636

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 637 HLAVQQAHVGLVPLL 651



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 427 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 486

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 487 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 543

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 544 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 603

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 604 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 660

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 661 EDEEGDTALHVALQRHQLLPLVADGAG 687



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 459 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 516

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 517 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 575

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 576 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 634


>AL691432-3|CAM12832.1|  753|Homo sapiens mindbomb homolog 2
           (Drosophila) protein.
          Length = 753

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 407 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 465

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 466 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 525

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 526 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 584

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 585 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 637

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 638 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 695

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 696 ADVSYTNHRGRSPLDLAA 713



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 426 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 485

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 486 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 540

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 541 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 595

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 596 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 654

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 655 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 713

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 714 EGRVLKALQ 722



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 382 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 440

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 441 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 485



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 378 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 436

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 437 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 494

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 495 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 554

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 555 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 607

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 608 HLAVQQAHVGLVPLL 622



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 398 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 457

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 458 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 514

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 515 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 574

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 575 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 631

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 632 EDEEGDTALHVALQRHQLLPLVADGAG 658



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 430 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 487

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 488 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 546

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 547 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 605


>AL691432-2|CAM12831.1|  999|Homo sapiens mindbomb homolog 2
           (Drosophila) protein.
          Length = 999

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 516 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 574

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 575 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 634

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 635 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 693

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 694 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 746

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 747 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 804

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 805 ADVSYTNHRGRSPLDLAA 822



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 594

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 595 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 649

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 650 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 704

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 705 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 763

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 764 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 822

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 823 EGRVLKALQ 831



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 491 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 549

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 550 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 594



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 487 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 545

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 546 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 603

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 604 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 663

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 664 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 716

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 717 HLAVQQAHVGLVPLL 731



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 507 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 566

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 567 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 623

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 624 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 740

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 741 EDEEGDTALHVALQRHQLLPLVADGAG 767



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 539 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 596

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 597 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 655

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 656 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 714


>AL691432-1|CAM12830.1|  948|Homo sapiens mindbomb homolog 2
           (Drosophila) protein.
          Length = 948

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 465 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 523

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 524 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 583

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 584 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 642

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 643 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 695

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 696 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 753

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 754 ADVSYTNHRGRSPLDLAA 771



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 484 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 543

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 544 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 598

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 599 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 653

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 654 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 712

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 713 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 771

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 772 EGRVLKALQ 780



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 440 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 498

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 499 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 543



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 436 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 494

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 495 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 552

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 553 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 612

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 613 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 665

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 666 HLAVQQAHVGLVPLL 680



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 456 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 515

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 516 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 572

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 573 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 632

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 633 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 689

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 690 EDEEGDTALHVALQRHQLLPLVADGAG 716



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 488 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 545

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 546 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 604

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 605 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 663


>AL031177-4|CAI43134.1|  193|Homo sapiens proteasome (prosome,
           macropain) 26S subunit, non-ATPase, 10 protein.
          Length = 193

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 57/184 (30%), Positives = 89/184 (48%), Gaps = 13/184 (7%)

Query: 363 VLHLVVMN---GGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENL 419
           V +L+V N    G+LE+   S     +KSL       D  G SPLH A+  G    ++ L
Sbjct: 5   VSNLMVCNLAYSGKLEELKESIL--ADKSLA---TRTDQAGWSPLHIAASAGRDEIVKAL 59

Query: 420 IRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASRE 479
           +  GA +N  N N  +PLH+AA   R   A  LL+        +  D    T +H A+ +
Sbjct: 60  LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP---DAKDHYEATAMHRAAAK 116

Query: 480 GHTRVVHLLLNRGALLH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTS 538
           G+ +++H+LL   A  + +D  G  PLHLA      +  +LL S  + +  + +K+  T 
Sbjct: 117 GNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE-NKEEKTP 175

Query: 539 LHLA 542
           L +A
Sbjct: 176 LQVA 179



 Score = 62.9 bits (146), Expect = 6e-09
 Identities = 45/134 (33%), Positives = 61/134 (45%), Gaps = 5/134 (3%)

Query: 435 SPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGAL 494
           SPLH AA  GR      LL        +N++   G TPLH A+ +    +  +LL  GA 
Sbjct: 42  SPLHIAASAGRDEIVKALLGKGAQVNAVNQN---GCTPLHYAASKNRHEIAVMLLEGGAN 98

Query: 495 LH-RDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIAL 553
              +DH     +H AA  G  K I +L    +    Q D +GNT LHLA  E +     L
Sbjct: 99  PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-DTEGNTPLHLACDEERVEEAKL 157

Query: 554 LLSMGCRLSYNNMD 567
           L+S G  +   N +
Sbjct: 158 LVSQGASIYIENKE 171



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 28/100 (28%), Positives = 51/100 (51%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A S N  +   + L   +    +D    TA H+A+A+ N  ++H +  Y    N +D  G
Sbjct: 80  AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 139

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMA 120
           NTPLH+A + E ++  + L+ Q     + N++ + P+ +A
Sbjct: 140 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 179



 Score = 56.4 bits (130), Expect = 6e-07
 Identities = 42/153 (27%), Positives = 66/153 (43%), Gaps = 7/153 (4%)

Query: 288 TSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLI 347
           T  D    +P+H AA     EIV  L+ +G+ +N +++   +PL  AAS+        L+
Sbjct: 34  TRTDQAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 93

Query: 348 RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYA 407
             GA+   KD      +H      G L+        H         N +D  G +PLH A
Sbjct: 94  EGGANPDAKDHYEATAMHRAAAK-GNLKMI------HILLYYKASTNIQDTEGNTPLHLA 146

Query: 408 SREGHIRSLENLIRLGACINLKNNNNESPLHFA 440
             E  +   + L+  GA I ++N   ++PL  A
Sbjct: 147 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 179



 Score = 53.2 bits (122), Expect = 5e-06
 Identities = 39/158 (24%), Positives = 68/158 (43%), Gaps = 13/158 (8%)

Query: 182 GYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVEL 241
           G+ P+H AA       ++  L  G Q        ++  +  G  PLH A      +   +
Sbjct: 40  GWSPLHIAASAGRDEIVKALLGKGAQ--------VNAVNQNGCTPLHYAASKNRHEIAVM 91

Query: 242 CLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCA 301
            L  GA    + H  +T +H A A+G L ++ ++   +     A     D +  TP+H A
Sbjct: 92  LLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-----ASTNIQDTEGNTPLHLA 146

Query: 302 AMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
              +  E    L+++G+ I   +KE ++PL +A    G
Sbjct: 147 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLG 184



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 33/149 (22%), Positives = 59/149 (39%), Gaps = 2/149 (1%)

Query: 21  AESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAG 80
           A SG +++     L++ S     D  G +  H A++     I+  +      +NA +  G
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 73

Query: 81  NTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFN 140
            TPLH A      +    LL+        +      +H A     + ++ +   YK+  N
Sbjct: 74  CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 133

Query: 141 VNQGGEHGRTALHFAAIHDHDLCAKILIT 169
           +      G T LH A   +    AK+L++
Sbjct: 134 IQD--TEGNTPLHLACDEERVEEAKLLVS 160



 Score = 47.2 bits (107), Expect = 3e-04
 Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 7/153 (4%)

Query: 220 DNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQ 279
           D  G  PLH A   G  + V+  L  GA+++    +  TP+H A ++   +I  ++    
Sbjct: 37  DQAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL--- 93

Query: 280 PKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAG 339
             E  A   + D  + T +H AA   + ++++ L+   +  N  D E  +PL LA     
Sbjct: 94  --EGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEER 151

Query: 340 WRTVHTLIRLGADIQLKDINSRNVLHLVVMNGG 372
                 L+  GA I ++  N      L V  GG
Sbjct: 152 VEEAKLLVSQGASIYIE--NKEEKTPLQVAKGG 182



 Score = 46.0 bits (104), Expect = 8e-04
 Identities = 31/144 (21%), Positives = 68/144 (47%), Gaps = 6/144 (4%)

Query: 224 NVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS-TPVHLACAQGALDIVKLMFTMQPKE 282
           N+ + +  + G ++ ++  + +   ++T+      +P+H+A + G  +IVK +       
Sbjct: 7   NLMVCNLAYSGKLEELKESILADKSLATRTDQAGWSPLHIAASAGRDEIVKALLG----- 61

Query: 283 KHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRT 342
           K A + + +    TP+H AA  +  EI   L+  G++ +  D    + +  AA++   + 
Sbjct: 62  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 121

Query: 343 VHTLIRLGADIQLKDINSRNVLHL 366
           +H L+   A   ++D      LHL
Sbjct: 122 IHILLYYKASTNIQDTEGNTPLHL 145



 Score = 45.2 bits (102), Expect = 0.001
 Identities = 37/159 (23%), Positives = 72/159 (45%), Gaps = 15/159 (9%)

Query: 115 APIHMATELNKVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHD-HDLCAKILITDLDA 173
           +P+H+A    +  +++      +   VN   ++G T LH+AA  + H++   +L    + 
Sbjct: 42  SPLHIAASAGRDEIVKALLGKGA--QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 99

Query: 174 EWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHG 233
           + K   +     +H AA   + + I + L +        +   ++ D EGN PLH A   
Sbjct: 100 DAKD--HYEATAMHRAAAKGNLKMIHILLYY--------KASTNIQDTEGNTPLHLACDE 149

Query: 234 GDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIV 272
             ++  +L +  GA I  +  +  TP  L  A+G L ++
Sbjct: 150 ERVEEAKLLVSQGASIYIENKEEKTP--LQVAKGGLGLI 186



 Score = 40.7 bits (91), Expect = 0.030
 Identities = 33/128 (25%), Positives = 53/128 (41%), Gaps = 9/128 (7%)

Query: 148 GRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQ 207
           G + LH AA    D   K L+    A+      NG  P+H AA         + L+ G  
Sbjct: 40  GWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 98

Query: 208 RGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQG 267
                       D+     +H A   G++K + + L   A  + Q  + +TP+HLAC + 
Sbjct: 99  PDAK--------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 150

Query: 268 ALDIVKLM 275
            ++  KL+
Sbjct: 151 RVEEAKLL 158


>AK098785-1|BAC05413.1|  802|Homo sapiens protein ( Homo sapiens
           cDNA FLJ25919 fis, clone CBR04994. ).
          Length = 802

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 472 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 530

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 531 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 590

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 591 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 649

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 650 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 702

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 703 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 760

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 761 ADVSYTNHRGRSPLDLAA 778



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 491 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 550

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 551 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 605

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 606 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 660

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 661 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 719

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 720 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 778

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 779 EGRVLKALQ 787



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 447 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 505

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 506 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 550



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 443 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 501

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 502 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 559

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 560 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 619

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 620 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 672

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 673 HLAVQQAHVGLVPLL 687



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 463 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 522

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 523 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 579

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 580 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 639

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 640 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 696

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 697 EDEEGDTALHVALQRHQLLPLVADGAG 723



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 495 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 552

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 553 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 611

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 612 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 670


>AK097106-1|BAC04952.1|  819|Homo sapiens protein ( Homo sapiens
           cDNA FLJ39787 fis, clone SPLEN2002744, weakly similar to
           ANKYRIN 2. ).
          Length = 819

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 336 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 394

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 395 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 454

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 455 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 513

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 514 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 566

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 567 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 624

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 625 ADVSYTNHRGRSPLDLAA 642



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 355 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 414

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 415 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 469

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 470 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 524

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 525 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 583

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 584 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 642

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 643 EGRVLKALQ 651



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 311 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 369

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 370 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 414



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 307 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 365

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 366 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 423

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 424 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 483

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 484 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 536

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 537 HLAVQQAHVGLVPLL 551



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 327 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 386

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 387 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 443

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 444 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 503

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 504 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 560

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 561 EDEEGDTALHVALQRHQLLPLVADGAG 587



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 359 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 416

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 417 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 475

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 476 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 534


>AK095914-1|BAC04646.1|  681|Homo sapiens protein ( Homo sapiens
           cDNA FLJ38595 fis, clone HEART2001773, weakly similar to
           ANKYRIN 2. ).
          Length = 681

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 198 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 256

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 257 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 316

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 317 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 375

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 376 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 428

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 429 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 486

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 487 ADVSYTNHRGRSPLDLAA 504



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 217 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 276

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 277 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 331

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 332 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 386

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 387 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 445

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 446 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 504

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 505 EGRVLKALQ 513



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 173 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 231

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 232 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 276



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 169 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 227

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 228 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 285

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 286 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 345

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 346 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 398

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 399 HLAVQQAHVGLVPLL 413



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 189 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 248

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 249 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 305

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 306 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 365

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 366 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 422

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 423 EDEEGDTALHVALQRHQLLPLVADGAG 449



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 221 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 278

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 279 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 337

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 338 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 396


>AK091610-1|BAC03707.1|  645|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34291 fis, clone FEBRA2004620, weakly similar to
           ANKYRIN 2. ).
          Length = 645

 Score = 70.1 bits (164), Expect = 4e-11
 Identities = 68/318 (21%), Positives = 135/318 (42%), Gaps = 13/318 (4%)

Query: 20  AAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNA 79
           AA  G V+  +RL L   + + + D  G TA H A+  N       + +     +A ++ 
Sbjct: 162 AAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINST 220

Query: 80  GNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATE--LNKVSVLQVFAKYKS 137
            +T LHVAV+   L+ +  L ++  + ++ +     P+H A         +++V  +  +
Sbjct: 221 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 280

Query: 138 LFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRT 197
           + +V      G T LH A++  H L  + ++            +G+  +H AA N     
Sbjct: 281 I-DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREV 339

Query: 198 IEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLS 257
            ++ ++ G    C     +++ + +   PLH AV    +  V L + +G  ++ +  +  
Sbjct: 340 AQILIREGR---CD----VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 392

Query: 258 TPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEG 317
           T +H+A  +  L  + L+      +         +Q       A +     +  +L  EG
Sbjct: 393 TALHVALQRHQL--LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEG 450

Query: 318 SDINPLDKERRSPLLLAA 335
           +D++  +   RSPL LAA
Sbjct: 451 ADVSYTNHRGRSPLDLAA 468



 Score = 67.7 bits (158), Expect = 2e-10
 Identities = 72/309 (23%), Positives = 124/309 (40%), Gaps = 18/309 (5%)

Query: 216 ISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLM 275
           + L D+EGN  LH A  G   +A  + L +G +        ST +H+A  +G L++V+ +
Sbjct: 181 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 240

Query: 276 FTMQPKEKHACLTSCDVQKMTPIHCA--AMFDHPEIVNYLIN-EGSDINPLDKERRSPLL 332
                 E+   +   D    TP+H A  A      IV  L      D+   + +  + L 
Sbjct: 241 C-----ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 295

Query: 333 LAASRAGWRTVHTLI-RLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQ 391
            A+ +     V  ++ R    +  K  +    LHL  +N  R        +  C+     
Sbjct: 296 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCD----- 350

Query: 392 LLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFA-ARYGRFHTAC 450
            +N ++    SPLH A ++ H+  +  L+  G  +N ++   ++ LH A  R+       
Sbjct: 351 -VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 409

Query: 451 QLLDSDKGTF-IINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAA 509
                D G   +++     GL P       G      L L    + + +H GR+PL LAA
Sbjct: 410 DGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 468

Query: 510 MSGYTKTIE 518
                K ++
Sbjct: 469 EGRVLKALQ 477



 Score = 56.8 bits (131), Expect = 4e-07
 Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)

Query: 483 RVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLA 542
           R + LL  R   +   + GR  L +AA  G  + I LL    + + D  D +GNT+LH A
Sbjct: 137 RALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGV-DLPDDEGNTALHYA 195

Query: 543 TMENKPSSIALLLSMGCRL-SYNNMDMSAIDYAIYYKFPEAALAM 586
            + N+P +  +LLS GCR  + N+   +A+  A+   F E   A+
Sbjct: 196 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 240



 Score = 56.0 bits (129), Expect = 7e-07
 Identities = 50/255 (19%), Positives = 101/255 (39%), Gaps = 13/255 (5%)

Query: 24  GNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTP 83
           GN    + L    P ++  ++ +GRTA   A+      ++  +      ++  D+ GNT 
Sbjct: 133 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 191

Query: 84  LHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKVSVLQVFAKYKSLFNVNQ 143
           LH A      +A   LL        +N      +H+A +   + V++   +     +VN 
Sbjct: 192 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC--DVNL 249

Query: 144 GGEHGRTALHFAAIHDHDLCAKI-LITDL-DAEWKKPCNNGYYPIHEAAKNASSRTIEVF 201
              H  T LH A          + ++T++ + +     + G+  +H A+    +  +   
Sbjct: 250 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 309

Query: 202 LQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSG-AKISTQQHDLSTPV 260
           L           Q++     +G   LH A      +  ++ +R G   ++ +   L +P+
Sbjct: 310 L-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 362

Query: 261 HLACAQGALDIVKLM 275
           HLA  Q  + +V L+
Sbjct: 363 HLAVQQAHVGLVPLL 377



 Score = 55.2 bits (127), Expect = 1e-06
 Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 13/267 (4%)

Query: 398 NTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDK 457
           N G + L  A+  G +  +  L++  A ++L ++   + LH+AA   +      LL +  
Sbjct: 153 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 212

Query: 458 GTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLH-RDHNGRNPLH--LAAMSGYT 514
               IN +     T LH+A + G   VV  L  RG  ++  D +   PLH  ++A +G +
Sbjct: 213 RADAINSTQS---TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 269

Query: 515 KTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRL--SYNNMDMSAID 572
             +E+L  V +  +   +  G T LH A+++    ++  +L+   +L  +      +A+ 
Sbjct: 270 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 329

Query: 573 YAIYYKFPEAALAMVTHEQRAKEV--MALRSDRHPCVTLALIAYMPRVFEAVQDKCITKA 630
            A      E A  ++   +    V    L+S  H  V  A +  +P + +A    C   A
Sbjct: 330 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA---GCSVNA 386

Query: 631 NCKKDSKSFYIKYSFEALCPQLMDEDG 657
             ++   + ++      L P + D  G
Sbjct: 387 EDEEGDTALHVALQRHQLLPLVADGAG 413



 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 8/179 (4%)

Query: 397 DNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSD 456
           D+ G + LHYA+      +   L+  G   +  N+   + LH A + G       L +  
Sbjct: 185 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCE-- 242

Query: 457 KGTFIINESDGEGLTPLH--IASREGHTRVVHLLLNRGAL--LHRDHNGRNPLHLAAMSG 512
           +G  + N  D    TPLH  I++  G + +V +L     +     +  G   LH A++ G
Sbjct: 243 RGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKG 301

Query: 513 YTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMG-CRLSYNNMDMSA 570
           +   +  + +    L+D   +DG T+LHLA + N      +L+  G C ++  N  + +
Sbjct: 302 HALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 360


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.321    0.135    0.400 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 161,611,819
Number of Sequences: 224733
Number of extensions: 6866630
Number of successful extensions: 37212
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 879
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 13472
Number of HSP's gapped (non-prelim): 9478
length of query: 1171
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1073
effective length of database: 51,211,004
effective search space: 54949407292
effective search space used: 54949407292
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 71 (32.7 bits)