Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002105-TA|BGIBMGA002105-PA|IPR000408|Regulator of
chromosome condensation, RCC1, IPR009091|Regulator of chromosome
condensation/beta-lactamase-inhibitor protein II
(480 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC053908-1|AAH53908.1| 522|Homo sapiens RCC2 protein protein. 437 e-122
BC042141-1|AAH42141.1| 522|Homo sapiens regulator of chromosome... 437 e-122
AJ421269-1|CAD13148.1| 522|Homo sapiens RCC1-like protein protein. 437 e-122
AB040903-1|BAA95994.1| 564|Homo sapiens KIAA1470 protein protein. 437 e-122
BC004933-1|AAH04933.1| 351|Homo sapiens RCC2 protein protein. 402 e-111
AL359612-1|CAB94882.1| 333|Homo sapiens hypothetical protein pr... 391 e-108
U50078-1|AAD12586.1| 4861|Homo sapiens p532 protein. 119 2e-26
BC039600-1|AAH39600.1| 1049|Homo sapiens hect domain and RLD 4 p... 117 8e-26
AY650033-1|AAV66579.1| 979|Homo sapiens HECT and RCC1 containin... 117 8e-26
AY221963-1|AAO65480.1| 1057|Homo sapiens HECT and RCC1 containin... 117 8e-26
AL356741-3|CAH74148.1| 1049|Homo sapiens hect domain and RLD 4 p... 117 8e-26
AL133551-3|CAI16032.1| 1049|Homo sapiens hect domain and RLD 4 p... 117 8e-26
AF071172-1|AAD08657.1| 4834|Homo sapiens HERC2 protein. 115 3e-25
D25215-1|BAA04945.2| 1054|Homo sapiens KIAA0032 protein. 112 2e-24
BC038960-1|AAH38960.1| 368|Homo sapiens HERC3 protein protein. 112 2e-24
AC098582-1|AAY41038.1| 382|Homo sapiens unknown protein. 112 2e-24
AF224249-1|AAO27475.1| 328|Homo sapiens HERC2 protein. 99 2e-20
AK096654-1|BAC04833.1| 531|Homo sapiens protein ( Homo sapiens ... 99 3e-20
AJ319660-1|CAC40027.1| 531|Homo sapiens guanine nucleotide exch... 99 3e-20
AF334406-1|AAK38372.1| 531|Homo sapiens CLLL7 protein protein. 99 3e-20
AL139321-5|CAH71047.1| 531|Homo sapiens regulator of chromosome... 98 5e-20
BC042047-1|AAH42047.2| 1022|Homo sapiens hect domain and RLD 6 p... 97 9e-20
AY653202-1|AAV66896.1| 364|Homo sapiens truncated HERC6 protein. 97 9e-20
AY653201-1|AAV66895.1| 986|Homo sapiens HERC6 splice variant pr... 97 9e-20
AF336798-1|AAQ14893.1| 1022|Homo sapiens HERC6 protein. 97 9e-20
BC029052-1|AAH29052.1| 551|Homo sapiens regulator of chromosome... 97 1e-19
AY341245-1|AAP88928.1| 551|Homo sapiens chromosome condensation... 97 1e-19
AL157813-1|CAH70795.1| 551|Homo sapiens regulator of chromosome... 97 1e-19
AF060219-1|AAC79987.1| 551|Homo sapiens RCC1-like G exchanging ... 97 1e-19
AB209543-1|BAD92780.1| 556|Homo sapiens RCC1-like G exchanging ... 97 1e-19
BC038104-1|AAH38104.1| 355|Homo sapiens RCBTB1 protein protein. 96 3e-19
X12654-1|CAA31182.1| 421|Homo sapiens protein ( Human mRNA for ... 94 8e-19
X06130-1|CAA29496.1| 421|Homo sapiens protein ( Human mRNA for ... 94 8e-19
D00591-1|BAA00469.1| 421|Homo sapiens RCC1 protein. 94 8e-19
CR407693-1|CAG28621.1| 421|Homo sapiens CHC1 protein. 94 8e-19
BC069198-1|AAH69198.1| 452|Homo sapiens regulator of chromosome... 94 8e-19
BC036903-1|AAH36903.1| 421|Homo sapiens regulator of chromosome... 94 8e-19
BC010067-1|AAH10067.1| 421|Homo sapiens regulator of chromosome... 94 8e-19
BC007300-1|AAH07300.1| 421|Homo sapiens regulator of chromosome... 94 8e-19
AL513497-2|CAI22287.1| 421|Homo sapiens regulator of chromosome... 94 8e-19
AF498924-1|AAM21072.1| 421|Homo sapiens regulator of chromosome... 94 8e-19
AB046813-1|BAB13419.1| 953|Homo sapiens KIAA1593 protein protein. 94 1e-18
AB027289-1|BAA88519.1| 1024|Homo sapiens cyclin-E binding protei... 93 2e-18
AY337518-1|AAR00320.1| 1024|Homo sapiens HECT E3 ubiquitin ligas... 92 5e-18
X97668-1|CAA66258.1| 815|Homo sapiens XLRP3 protein. 91 8e-18
U57629-1|AAC50481.1| 815|Homo sapiens retinitis pigmentosa GTPa... 91 8e-18
BC031624-1|AAH31624.1| 480|Homo sapiens RPGR protein protein. 91 8e-18
AL606748-2|CAI95407.1| 815|Homo sapiens retinitis pigmentosa GT... 91 8e-18
AK223491-1|BAD97211.1| 815|Homo sapiens retinitis pigmentosa GT... 91 8e-18
AJ238395-1|CAB54002.1| 646|Homo sapiens RPGR protein protein. 91 8e-18
BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9 p... 91 1e-17
BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis ... 91 1e-17
AY653203-1|AAV66897.1| 322|Homo sapiens truncated HERC6 protein. 91 1e-17
AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERC... 91 1e-17
AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek... 91 1e-17
AC007055-4|AAD31939.1| 414|Homo sapiens protein ( Homo sapiens ... 91 1e-17
AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein. 91 1e-17
AJ318463-1|CAC86116.1| 815|Homo sapiens retinitis pigmentosa GT... 90 1e-17
AF225407-1|AAO27483.1| 409|Homo sapiens HERC2 protein. 90 1e-17
AL356741-1|CAH74146.1| 907|Homo sapiens hect domain and RLD 4 p... 86 3e-16
AL133551-1|CAI16031.1| 907|Homo sapiens hect domain and RLD 4 p... 86 3e-16
BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis ... 79 3e-14
BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8 p... 79 3e-14
BC065375-1|AAH65375.1| 458|Homo sapiens secretion regulating gu... 79 3e-14
AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8... 79 3e-14
AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a... 79 3e-14
AJ243950-1|CAB60832.1| 458|Homo sapiens deafness locus associat... 79 3e-14
AJ243951-1|CAB60833.1| 288|Homo sapiens deafness locus associat... 75 4e-13
AC004460-2|AAC06339.1| 371|Homo sapiens WUGSC:H_DJ1086D14.2 pro... 75 7e-13
DQ005634-1|AAY55907.1| 1196|Homo sapiens inhibitor of Bruton's t... 73 2e-12
DQ005633-1|AAY55906.1| 1353|Homo sapiens inhibitor of Bruton's t... 73 2e-12
BC113698-1|AAI13699.1| 1353|Homo sapiens inhibitor of Bruton aga... 73 2e-12
BC113696-1|AAI13697.1| 1353|Homo sapiens inhibitor of Bruton aga... 73 2e-12
AL050333-2|CAI23416.1| 1187|Homo sapiens RP1-93K22.1 protein. 73 2e-12
AB037838-1|BAA92655.2| 1379|Homo sapiens KIAA1417 protein protein. 73 2e-12
AK092403-1|BAC03879.1| 184|Homo sapiens protein ( Homo sapiens ... 70 2e-11
BC032712-1|AAH32712.1| 454|Homo sapiens WBSCR16 protein protein. 68 6e-11
BC019008-1|AAH19008.1| 464|Homo sapiens Williams-Beuren syndrom... 68 6e-11
BC007823-1|AAH07823.1| 464|Homo sapiens Williams-Beuren syndrom... 68 6e-11
AF410455-1|AAM62304.1| 464|Homo sapiens RCC1-like G exchanging ... 68 6e-11
BC040929-1|AAH40929.1| 651|Homo sapiens HERC1 protein protein. 64 8e-10
BC040695-1|AAH40695.1| 358|Homo sapiens WBSCR16 protein protein. 64 1e-09
BC029174-1|AAH29174.1| 812|Homo sapiens ALS2 protein protein. 60 1e-08
AF391100-1|AAL14103.1| 1657|Homo sapiens alsin protein. 60 1e-08
AC007279-1|AAY15058.1| 1598|Homo sapiens unknown protein. 60 1e-08
AB053305-1|BAB69014.1| 1657|Homo sapiens ALS2 protein. 60 1e-08
AB046783-1|BAB13389.2| 1658|Homo sapiens KIAA1563 protein protein. 60 1e-08
AL359257-2|CAI39759.1| 4640|Homo sapiens AC001226.5 protein. 60 2e-08
AL159158-1|CAI16842.1| 4640|Homo sapiens AC001226.5 protein. 60 2e-08
AL159154-1|CAH73736.1| 4640|Homo sapiens AC001226.5 protein. 60 2e-08
AF075587-1|AAC39928.1| 4641|Homo sapiens protein associated with... 60 2e-08
BC071576-1|AAH71576.1| 1237|Homo sapiens ALS2 protein protein. 60 2e-08
AK023024-1|BAB14362.1| 396|Homo sapiens protein ( Homo sapiens ... 56 2e-07
AB053306-1|BAB69015.1| 396|Homo sapiens ALS2 protein. 56 4e-07
BC113826-1|AAI13827.1| 244|Homo sapiens RCCD1 protein protein. 54 1e-06
AF225404-1|AAO27482.1| 259|Homo sapiens HERC2 protein. 52 6e-06
AY650032-1|AAV66578.1| 117|Homo sapiens HECT and RCC1 containin... 44 0.001
BC067293-1|AAH67293.1| 580|Homo sapiens F-box protein 24 protein. 42 0.006
AC069281-1|AAP21863.1| 580|Homo sapiens unknown protein. 42 0.006
AY650034-1|AAV66580.1| 110|Homo sapiens HECT and RCC1 containin... 41 0.008
BC009336-1|AAH09336.2| 326|Homo sapiens NEK9 protein protein. 33 2.9
BC059408-1|AAH59408.1| 267|Homo sapiens ovo-like 1(Drosophila) ... 31 8.9
BC043146-1|AAH43146.1| 244|Homo sapiens OVOL1 protein protein. 31 8.9
>BC053908-1|AAH53908.1| 522|Homo sapiens RCC2 protein protein.
Length = 522
Score = 437 bits (1076), Expect = e-122
Identities = 202/419 (48%), Positives = 282/419 (67%), Gaps = 8/419 (1%)
Query: 70 KTPGVLMIAGLVSWDLTARRDNNPTKRTH----PNLYTFHKF---TDRRYRLIVSGCTAG 122
K G L+I G +WDL R++ + + NL+ H++ R R +VSG A
Sbjct: 101 KCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAA 160
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L++ EG+ +++GRN GQLG GDT P L+ L + I+ AA GR+HTL +T+T
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGM 242
G V+A G+NK GQ GLGN T + P +I YNG PI K+ CGAEFSMI+DC GNL+SFG
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 243 PEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN 302
PEYGQLGHN+DGK+ + ++ + E +P+++ ++I+K+KDG I PV +V + D++CG N
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
HT+ +DS KR FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG ++ G T S AV+
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
Query: 363 DQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYG 422
+ G LF +G T + E+ MYPK V DL GW I+S+ +SI++AAD+S I+WG SPT+G
Sbjct: 401 EVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFG 460
Query: 423 ELGMGEIN-KSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNNIEEVKQKLDTIPAFEP 480
ELG G+ KS+ +EV +D + QVAMGYSH+L++ + E K+K+ +P + P
Sbjct: 461 ELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNP 519
>BC042141-1|AAH42141.1| 522|Homo sapiens regulator of chromosome
condensation 2 protein.
Length = 522
Score = 437 bits (1076), Expect = e-122
Identities = 202/419 (48%), Positives = 282/419 (67%), Gaps = 8/419 (1%)
Query: 70 KTPGVLMIAGLVSWDLTARRDNNPTKRTH----PNLYTFHKF---TDRRYRLIVSGCTAG 122
K G L+I G +WDL R++ + + NL+ H++ R R +VSG A
Sbjct: 101 KCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAA 160
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L++ EG+ +++GRN GQLG GDT P L+ L + I+ AA GR+HTL +T+T
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGM 242
G V+A G+NK GQ GLGN T + P +I YNG PI K+ CGAEFSMI+DC GNL+SFG
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 243 PEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN 302
PEYGQLGHN+DGK+ + ++ + E +P+++ ++I+K+KDG I PV +V + D++CG N
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
HT+ +DS KR FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG ++ G T S AV+
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
Query: 363 DQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYG 422
+ G LF +G T + E+ MYPK V DL GW I+S+ +SI++AAD+S I+WG SPT+G
Sbjct: 401 EVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFG 460
Query: 423 ELGMGEIN-KSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNNIEEVKQKLDTIPAFEP 480
ELG G+ KS+ +EV +D + QVAMGYSH+L++ + E K+K+ +P + P
Sbjct: 461 ELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNP 519
>AJ421269-1|CAD13148.1| 522|Homo sapiens RCC1-like protein protein.
Length = 522
Score = 437 bits (1076), Expect = e-122
Identities = 202/419 (48%), Positives = 282/419 (67%), Gaps = 8/419 (1%)
Query: 70 KTPGVLMIAGLVSWDLTARRDNNPTKRTH----PNLYTFHKF---TDRRYRLIVSGCTAG 122
K G L+I G +WDL R++ + + NL+ H++ R R +VSG A
Sbjct: 101 KCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAA 160
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L++ EG+ +++GRN GQLG GDT P L+ L + I+ AA GR+HTL +T+T
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGM 242
G V+A G+NK GQ GLGN T + P +I YNG PI K+ CGAEFSMI+DC GNL+SFG
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 243 PEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN 302
PEYGQLGHN+DGK+ + ++ + E +P+++ ++I+K+KDG I PV +V + D++CG N
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
HT+ +DS KR FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG ++ G T S AV+
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
Query: 363 DQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYG 422
+ G LF +G T + E+ MYPK V DL GW I+S+ +SI++AAD+S I+WG SPT+G
Sbjct: 401 EVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFG 460
Query: 423 ELGMGEIN-KSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNNIEEVKQKLDTIPAFEP 480
ELG G+ KS+ +EV +D + QVAMGYSH+L++ + E K+K+ +P + P
Sbjct: 461 ELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNP 519
>AB040903-1|BAA95994.1| 564|Homo sapiens KIAA1470 protein protein.
Length = 564
Score = 437 bits (1076), Expect = e-122
Identities = 202/419 (48%), Positives = 282/419 (67%), Gaps = 8/419 (1%)
Query: 70 KTPGVLMIAGLVSWDLTARRDNNPTKRTH----PNLYTFHKF---TDRRYRLIVSGCTAG 122
K G L+I G +WDL R++ + + NL+ H++ R R +VSG A
Sbjct: 143 KCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAA 202
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L++ EG+ +++GRN GQLG GDT P L+ L + I+ AA GR+HTL +T+T
Sbjct: 203 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 262
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGM 242
G V+A G+NK GQ GLGN T + P +I YNG PI K+ CGAEFSMI+DC GNL+SFG
Sbjct: 263 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 322
Query: 243 PEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN 302
PEYGQLGHN+DGK+ + ++ + E +P+++ ++I+K+KDG I PV +V + D++CG N
Sbjct: 323 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 382
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
HT+ +DS KR FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG ++ G T S AV+
Sbjct: 383 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 442
Query: 363 DQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYG 422
+ G LF +G T + E+ MYPK V DL GW I+S+ +SI++AAD+S I+WG SPT+G
Sbjct: 443 EVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFG 502
Query: 423 ELGMGEIN-KSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNNIEEVKQKLDTIPAFEP 480
ELG G+ KS+ +EV +D + QVAMGYSH+L++ + E K+K+ +P + P
Sbjct: 503 ELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNP 561
>BC004933-1|AAH04933.1| 351|Homo sapiens RCC2 protein protein.
Length = 351
Score = 402 bits (991), Expect = e-111
Identities = 179/348 (51%), Positives = 245/348 (70%), Gaps = 1/348 (0%)
Query: 134 YTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+++GRN GQLG GDT P L+ L + I+ AA GR+HTL +T+TG V+A G+NK
Sbjct: 1 WSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKM 60
Query: 194 GQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTD 253
GQ GLGN T + P +I YNG PI K+ CGAEFSMI+DC GNL+SFG PEYGQLGHN+D
Sbjct: 61 GQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSD 120
Query: 254 GKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRA 313
GK+ + ++ + E +P+++ ++I+K+KDG I PV +V + D++CG NHT+ +DS KR
Sbjct: 121 GKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRV 180
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG ++ G T S AV++ G LF +G T
Sbjct: 181 FSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGAT 240
Query: 374 KRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEIN-KS 432
+ E+ MYPK V DL GW I+S+ +SI++AAD+S I+WG SPT+GELG G+ KS
Sbjct: 241 NTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKS 300
Query: 433 TAKPKEVSRMDSLGITQVAMGYSHTLLLCDNNIEEVKQKLDTIPAFEP 480
+ +EV +D + QVAMGYSH+L++ + E K+K+ +P + P
Sbjct: 301 STAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNP 348
Score = 56.0 bits (129), Expect = 3e-07
Identities = 42/162 (25%), Positives = 71/162 (43%), Gaps = 26/162 (16%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPEL-KGKNIIHAAVG 172
++ + C H++ ++E G + FG N GQLG G+ T +VP + G+ I A G
Sbjct: 33 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ-TDAVPSPAQIMYNGQPITKMACG 91
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN------------------ 214
++ + G +Y+ G + GQ G + I + RI+Y+
Sbjct: 92 AEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDG 151
Query: 215 ------GTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGH 250
+ V CGA +++LD + S+G YG+LGH
Sbjct: 152 QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGH 193
Score = 34.3 bits (75), Expect = 0.96
Identities = 32/136 (23%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHT 176
C A H++++ + +++G G+LG + VP LV + G+ G +
Sbjct: 166 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 225
Query: 177 LFVTDTGCVYACG-DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNG 235
V++ G ++ G N S + + Q L RI+ + CG + S+I+ +
Sbjct: 226 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIR-------SLACG-KSSIIVAADE 277
Query: 236 NLHSFG-MPEYGQLGH 250
+ S+G P +G+LG+
Sbjct: 278 STISWGPSPTFGELGY 293
>AL359612-1|CAB94882.1| 333|Homo sapiens hypothetical protein
protein.
Length = 333
Score = 391 bits (963), Expect = e-108
Identities = 172/321 (53%), Positives = 231/321 (71%)
Query: 108 TDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNII 167
T R R +VSG A HS+L++ EG+ +++GRN GQLG GDT P L+ L + I+
Sbjct: 2 TRGRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 61
Query: 168 HAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
AA GR+HTL +T+TG V+A G+NK GQ GLGN T + P +I YNG PI K+ CGAEF
Sbjct: 62 SAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEF 121
Query: 228 SMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYIT 287
SMI+DC GNL+SFG PEYGQLGHN+DGK+ + ++ + E +P+++ ++I+K+KDG I
Sbjct: 122 SMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQIL 181
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
PV +V + D++CG NHT+ +DS KR FSWGFGG+GRLGHAEQKDE VPRL+K FD GRG
Sbjct: 182 PVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRG 241
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIA 407
++ G T S AV++ G LF +G T + E+ MYPK V DL GW I+S+ +SI++A
Sbjct: 242 ASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVA 301
Query: 408 ADDSLIAWGVSPTYGELGMGE 428
AD+S I+WG SPT+GELG G+
Sbjct: 302 ADESTISWGPSPTFGELGYGD 322
>U50078-1|AAD12586.1| 4861|Homo sapiens p532 protein.
Length = 4861
Score = 119 bits (287), Expect = 2e-26
Identities = 100/354 (28%), Positives = 160/354 (45%), Gaps = 43/354 (12%)
Query: 122 GHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTD 181
G + +VSE E Y +G N+ QL G P+L P I A G++ T ++
Sbjct: 363 GDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVIST 420
Query: 182 TGCVYACGDNKSGQCGLGNTTPQ--ILKPTRIKYNGTPIVKVGCGAE-FSMILDCNGNLH 238
G V ACG G+ GLG++ Q + K T + V G++ ++ G +
Sbjct: 421 DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480
Query: 239 SFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLS 298
S+G +YG+LGH +ST + PK I P++ +V +S
Sbjct: 481 SWGDGDYGKLGHGN------SST------QKYPKLIQ-----------GPLQGKVVVCVS 517
Query: 299 CGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
G H+ A+ ++WG G FGRLGH + N+P L+K VG V CG +++
Sbjct: 518 AGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG----EVSCGSSHT 573
Query: 359 LAVNDQG-ALFMFGQTKR----TGEAN-MY-PKPVHDLTGWNIKSV-GTSNTSIVIAADD 410
+A++ G ++ FG G+ N +Y PK + L G I+ V S +S+ + +
Sbjct: 574 IALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
+ AWG LG G + +PK + + + I V++G SH L L +N
Sbjct: 634 QVYAWGCGAC---LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
Score = 111 bits (268), Expect = 4e-24
Identities = 89/351 (25%), Positives = 172/351 (49%), Gaps = 41/351 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG---KNIIHAAVGRHH 175
C + ++ G G + G+LG G++ V ++ L+G ++ + H
Sbjct: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093
Query: 176 TLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCN 234
++ +T++G V++ GD G+ G GN+ Q +P +I+ G +V++ CG + S ++ +
Sbjct: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQ-RRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L +FG +YG+LG TS K +P+++T + +GY I
Sbjct: 4153 GKLFTFGNGDYGRLGLGN------TSNK------KLPERVT-----ALEGY-------QI 4188
Query: 295 VDLSCGNNHTVAIDS-MKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++CG NHT+A+ + +++G G +G+LG ++ P+ I G G++ V C
Sbjct: 4189 GQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVL--CGIGIKKVAC 4246
Query: 354 GGTYSLAVNDQGALFMFGQTKRTG------EANMYPKPVHDLTGWNIKSVGT-SNTSIVI 406
G +S+A+ G ++ FGQ + G + P+ + L G I+ V + ++ +
Sbjct: 4247 GTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLAL 4306
Query: 407 AADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
A++ + AWG S + G+LG+G N +P V+ + + Q++ G H+
Sbjct: 4307 ASNGDVYAWG-SNSEGQLGLGHTN-HVREPTLVTGLQGKNVRQISAGRCHS 4355
Score = 99 bits (238), Expect = 2e-20
Identities = 76/249 (30%), Positives = 118/249 (47%), Gaps = 29/249 (11%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C HS +V+ +G+ +TFG G+LG G+T + +PE V L+G I A G
Sbjct: 4136 VVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGL 4195
Query: 174 HHTLFVT-DTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN-GTPIVKVGCGAEFSMIL 231
+HTL V+ D V+A GD G+ GLGN+T + P +I G I KV CG +FS+ L
Sbjct: 4196 NHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS-SPQKIDVLCGIGIKKVACGTQFSVAL 4254
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
+G++++FG D + + H P+QI + +
Sbjct: 4255 TKDGHVYTFGQ----------DRLIGLPEGRARNHNR--PQQIPV------------LAG 4290
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
V I D++ G HT+A+ S ++WG G+LG P L+ G+ VR +
Sbjct: 4291 VIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ--GKNVRQI 4348
Query: 352 HCGGTYSLA 360
G +S A
Sbjct: 4349 SAGRCHSAA 4357
Score = 84.6 bits (200), Expect = 7e-16
Identities = 78/286 (27%), Positives = 131/286 (45%), Gaps = 40/286 (13%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPE 244
VY G + GQ L ++ P + + +V CG + ++ NG + + G
Sbjct: 3999 VYLWGAGRHGQ--LAEAGRNVMVPAAAP-SFSQAQQVICGQNCTFVIQANGTVLACGEGS 4055
Query: 245 YGQLGH-NTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN- 302
YG+LG N+D + +T + + G++ VT + SCG++
Sbjct: 4056 YGRLGQGNSDDLHVLT------------------VISALQGFV-----VTQLVTSCGSDG 4092
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H++A+ FSWG G +G+LGH + PR I+ G V + CG +S V
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQ--GEEVVQMSCGFKHSAVVT 4150
Query: 363 DQGALFMFGQTK--RTGEAN----MYPKPVHDLTGWNIKSVGTS-NTSIVIAADDSLI-A 414
G LF FG R G N P+ V L G+ I V N ++ ++AD S++ A
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWA 4210
Query: 415 WGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+G YG+LG+G + + + P+++ + +GI +VA G ++ L
Sbjct: 4211 FG-DGDYGKLGLGN-STAKSSPQKIDVLCGIGIKKVACGTQFSVAL 4254
Score = 83.0 bits (196), Expect = 2e-15
Identities = 86/344 (25%), Positives = 147/344 (42%), Gaps = 44/344 (12%)
Query: 132 EAYTFGRNACGQLG-FGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGD 190
+ Y +G GQL G V VP P + G++ T + G V ACG+
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVM--VPAAAPSFSQAQQV--ICGQNCTFVIQANGTVLACGE 4053
Query: 191 NKSGQCGLGNTTPQILKPTRIKYNGTPIVKV--GCGAE-FSMILDCNGNLHSFGMPEYGQ 247
G+ G GN+ + G + ++ CG++ SM L +G + S+G +YG+
Sbjct: 4054 GSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 4113
Query: 248 LGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAI 307
LGH + + P+QI ++ +V +SCG H+ +
Sbjct: 4114 LGHGNSDR------------QRRPRQIEA------------LQGEEVVQMSCGFKHSAVV 4149
Query: 308 DSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGAL 367
S + F++G G +GRLG ++ +P + + G + V CG ++LAV+ G++
Sbjct: 4150 TSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE--GYQIGQVACGLNHTLAVSADGSM 4207
Query: 368 ---FMFGQTKRTG----EANMYPKPVHDLTGWNIKSVGT-SNTSIVIAADDSLIAWGVSP 419
F G + G A P+ + L G IK V + S+ + D + +G
Sbjct: 4208 VWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR 4267
Query: 420 TYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
G L G ++ +P+++ + + I VA+G HTL L N
Sbjct: 4268 LIG-LPEGRA-RNHNRPQQIPVLAGVIIEDVAVGAEHTLALASN 4309
Score = 82.6 bits (195), Expect = 3e-15
Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 33/292 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
+L+ S + GHS+ ++E GE +++G G+LG G++ + P + L+G+ ++ + G
Sbjct: 4083 QLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4142
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILD 232
H+ VT G ++ G+ G+ GLGNT+ + L G I +V CG ++ +
Sbjct: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVS 4202
Query: 233 CNGNL-HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
+G++ +FG +YG+LG ST KS I +
Sbjct: 4203 ADGSMVWAFGDGDYGKLG-------LGNST-----------------AKSSPQKIDVLCG 4238
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+ I ++CG +VA+ +++G L ++ N P+ I G + V
Sbjct: 4239 IGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVL--AGVIIEDV 4296
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSV 397
G ++LA+ G ++ +G G N +P V L G N++ +
Sbjct: 4297 AVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQI 4348
Score = 68.1 bits (159), Expect = 6e-11
Identities = 36/108 (33%), Positives = 59/108 (54%), Gaps = 4/108 (3%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSV-PELVPELKGKNIIHAAVGRHHTLFVTDT 182
S+ ++ G+ Y +G AC LG G + ++ P+L+ EL I+ ++G H L ++
Sbjct: 626 SLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHD 683
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSM 229
VYA G+N GQCG GN+T I KP ++ +G I ++ G S+
Sbjct: 684 NEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSL 731
Score = 63.3 bits (147), Expect = 2e-09
Identities = 44/140 (31%), Positives = 70/140 (50%), Gaps = 7/140 (5%)
Query: 119 CTAGHSVLVSEEGEA-YTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTL 177
C + H++ +S++G ++FG G+LG GDT P+++ L+G I G +L
Sbjct: 568 CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSL 627
Query: 178 FVTDTGCVYACGDNKSGQC-GLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNG 235
+T TG VYA G G C G G++ L+P I + T IV V G + L +
Sbjct: 628 ALTSTGQVYAWG---CGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
Query: 236 NLHSFGMPEYGQLGH-NTDG 254
++++G GQ G N+ G
Sbjct: 685 EVYAWGNNSMGQCGQGNSTG 704
Score = 59.7 bits (138), Expect = 2e-08
Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 3/140 (2%)
Query: 112 YRLIVSGCTAGHSVLVSEEGE-AYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAA 170
Y++ C H++ VS +G + FG G+LG G++ +S P+ + L G I A
Sbjct: 4186 YQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVA 4245
Query: 171 VGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSM 229
G ++ +T G VY G ++ G +P +I G I V GAE ++
Sbjct: 4246 CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNH-NRPQQIPVLAGVIIEDVAVGAEHTL 4304
Query: 230 ILDCNGNLHSFGMPEYGQLG 249
L NG+++++G GQLG
Sbjct: 4305 ALASNGDVYAWGSNSEGQLG 4324
Score = 47.6 bits (108), Expect = 1e-04
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 121 AGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR-HHTLFV 179
A H++ ++ G+ Y +G N+ GQLG G T P LV L+GKN+ + GR H +
Sbjct: 4300 AEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Query: 180 TDTGCVYACGDNKSGQCGLGNTTP 203
A G + Q GL +T P
Sbjct: 4360 APPVPPRAPGVSVPLQLGLPDTVP 4383
>BC039600-1|AAH39600.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 117 bits (282), Expect = 8e-26
Identities = 97/330 (29%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNI 166
F ++R R + GC H+V V ++G YT G N GQLG + R PE V L +NI
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQNI 86
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA 225
+ + G HTL + D G VYA G + GQ GL + I P IK + IV+V CG
Sbjct: 87 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY 146
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
S+ L + +G +YGQLG TD K KQ + + KS G
Sbjct: 147 YHSLALSKASEVFCWGQNKYGQLGLGTDCK----------------KQTSPQLLKSLLG- 189
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
+ + ++ G H+ + F WG FG+LG ++ D VP L+K +
Sbjct: 190 ------IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS-- 241
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV-- 397
+ + + CG ++ A+ +G +F F GQ ++ + P+ V +L G + +
Sbjct: 242 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIAC 301
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G +TS + + + ++G+ G+LG G
Sbjct: 302 GRQHTSAFVPSSGRIYSFGLGGN-GQLGTG 330
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 295
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 296 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 93.5 bits (222), Expect = 1e-18
Identities = 91/334 (27%), Positives = 144/334 (43%), Gaps = 43/334 (12%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G + KP ++ + IV V CG ++ L+ G ++++G+ GQLG
Sbjct: 64 GQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG--- 117
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
V S + +P+ I KS + D+ IV ++CG H++A+
Sbjct: 118 ----LVGSEECI----RVPRNI-----KS-------LSDIQIVQVACGYYHSLALSKASE 157
Query: 313 AFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF--- 368
F WG +G+LG + K + P+L+K +G V GG +S + GA+F
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 369 --MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGE 423
FGQ E + Y P + L I + G +T+ + + + +G YG+
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG-GYGQ 273
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
LG + P++V + +T++A G HT
Sbjct: 274 LGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 306
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 42/285 (14%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
GQLGH K P+Q+ ++ IV +SCG HT
Sbjct: 63 LGQLGHEKSRKK--------------PEQVVALDAQN------------IVAVSCGEAHT 96
Query: 305 VAIDSMKRAFSWGFGGFGRLGHAEQKD-ENVPRLIKYFDTVGRGVRSVHCGGTYSLAVND 363
+A++ + ++WG G+LG ++ VPR IK + + V CG +SLA++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSK 154
Query: 364 QGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAW 415
+F +GQ K + G + P+ + L G V S V+ ++ W
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
G + +G+LG+ + N P + + S I + G HT L
Sbjct: 215 GRN-KFGQLGLNDENDRYV-PNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 299
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 34.7 bits (76), Expect = 0.73
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 394 IKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
++ VG V DD + G+LG KS KP++V +D+ I V+ G
Sbjct: 36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPEQVVALDAQNIVAVSCG 92
Query: 454 YSHTLLLCD 462
+HTL L D
Sbjct: 93 EAHTLALND 101
>AY650033-1|AAV66579.1| 979|Homo sapiens HECT and RCC1 containing
protein 4 isoform 3 protein.
Length = 979
Score = 117 bits (282), Expect = 8e-26
Identities = 97/330 (29%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNI 166
F ++R R + GC H+V V ++G YT G N GQLG + R PE V L +NI
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQNI 86
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA 225
+ + G HTL + D G VYA G + GQ GL + I P IK + IV+V CG
Sbjct: 87 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY 146
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
S+ L + +G +YGQLG TD K KQ + + KS G
Sbjct: 147 YHSLALSKASEVFCWGQNKYGQLGLGTDCK----------------KQTSPQLLKSLLG- 189
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
+ + ++ G H+ + F WG FG+LG ++ D VP L+K +
Sbjct: 190 ------IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS-- 241
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV-- 397
+ + + CG ++ A+ +G +F F GQ ++ + P+ V +L G + +
Sbjct: 242 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIAC 301
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G +TS + + + ++G+ G+LG G
Sbjct: 302 GRQHTSAFVPSSGRIYSFGLGGN-GQLGTG 330
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 295
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 296 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 93.5 bits (222), Expect = 1e-18
Identities = 91/334 (27%), Positives = 144/334 (43%), Gaps = 43/334 (12%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G + KP ++ + IV V CG ++ L+ G ++++G+ GQLG
Sbjct: 64 GQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG--- 117
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
V S + +P+ I KS + D+ IV ++CG H++A+
Sbjct: 118 ----LVGSEECI----RVPRNI-----KS-------LSDIQIVQVACGYYHSLALSKASE 157
Query: 313 AFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF--- 368
F WG +G+LG + K + P+L+K +G V GG +S + GA+F
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 369 --MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGE 423
FGQ E + Y P + L I + G +T+ + + + +G YG+
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG-GYGQ 273
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
LG + P++V + +T++A G HT
Sbjct: 274 LGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 306
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 42/285 (14%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
GQLGH K P+Q+ ++ IV +SCG HT
Sbjct: 63 LGQLGHEKSRKK--------------PEQVVALDAQN------------IVAVSCGEAHT 96
Query: 305 VAIDSMKRAFSWGFGGFGRLGHAEQKD-ENVPRLIKYFDTVGRGVRSVHCGGTYSLAVND 363
+A++ + ++WG G+LG ++ VPR IK + + V CG +SLA++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSK 154
Query: 364 QGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAW 415
+F +GQ K + G + P+ + L G V S V+ ++ W
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
G + +G+LG+ + N P + + S I + G HT L
Sbjct: 215 GRN-KFGQLGLNDENDRYV-PNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 299
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 34.7 bits (76), Expect = 0.73
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 394 IKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
++ VG V DD + G+LG KS KP++V +D+ I V+ G
Sbjct: 36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPEQVVALDAQNIVAVSCG 92
Query: 454 YSHTLLLCD 462
+HTL L D
Sbjct: 93 EAHTLALND 101
>AY221963-1|AAO65480.1| 1057|Homo sapiens HECT and RCC1 containing
protein 4 isoform 1 protein.
Length = 1057
Score = 117 bits (282), Expect = 8e-26
Identities = 97/330 (29%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNI 166
F ++R R + GC H+V V ++G YT G N GQLG + R PE V L +NI
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQNI 86
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA 225
+ + G HTL + D G VYA G + GQ GL + I P IK + IV+V CG
Sbjct: 87 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY 146
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
S+ L + +G +YGQLG TD K KQ + + KS G
Sbjct: 147 YHSLALSKASEVFCWGQNKYGQLGLGTDCK----------------KQTSPQLLKSLLG- 189
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
+ + ++ G H+ + F WG FG+LG ++ D VP L+K +
Sbjct: 190 ------IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS-- 241
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV-- 397
+ + + CG ++ A+ +G +F F GQ ++ + P+ V +L G + +
Sbjct: 242 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIAC 301
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G +TS + + + ++G+ G+LG G
Sbjct: 302 GRQHTSAFVPSSGRIYSFGLGGN-GQLGTG 330
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 295
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 296 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 93.5 bits (222), Expect = 1e-18
Identities = 91/334 (27%), Positives = 144/334 (43%), Gaps = 43/334 (12%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G + KP ++ + IV V CG ++ L+ G ++++G+ GQLG
Sbjct: 64 GQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG--- 117
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
V S + +P+ I KS + D+ IV ++CG H++A+
Sbjct: 118 ----LVGSEECI----RVPRNI-----KS-------LSDIQIVQVACGYYHSLALSKASE 157
Query: 313 AFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF--- 368
F WG +G+LG + K + P+L+K +G V GG +S + GA+F
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 369 --MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGE 423
FGQ E + Y P + L I + G +T+ + + + +G YG+
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG-GYGQ 273
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
LG + P++V + +T++A G HT
Sbjct: 274 LGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 306
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 42/285 (14%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
GQLGH K P+Q+ ++ IV +SCG HT
Sbjct: 63 LGQLGHEKSRKK--------------PEQVVALDAQN------------IVAVSCGEAHT 96
Query: 305 VAIDSMKRAFSWGFGGFGRLGHAEQKD-ENVPRLIKYFDTVGRGVRSVHCGGTYSLAVND 363
+A++ + ++WG G+LG ++ VPR IK + + V CG +SLA++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSK 154
Query: 364 QGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAW 415
+F +GQ K + G + P+ + L G V S V+ ++ W
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
G + +G+LG+ + N P + + S I + G HT L
Sbjct: 215 GRN-KFGQLGLNDENDRYV-PNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 299
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 34.7 bits (76), Expect = 0.73
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 394 IKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
++ VG V DD + G+LG KS KP++V +D+ I V+ G
Sbjct: 36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPEQVVALDAQNIVAVSCG 92
Query: 454 YSHTLLLCD 462
+HTL L D
Sbjct: 93 EAHTLALND 101
>AL356741-3|CAH74148.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 117 bits (282), Expect = 8e-26
Identities = 97/330 (29%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNI 166
F ++R R + GC H+V V ++G YT G N GQLG + R PE V L +NI
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQNI 86
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA 225
+ + G HTL + D G VYA G + GQ GL + I P IK + IV+V CG
Sbjct: 87 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY 146
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
S+ L + +G +YGQLG TD K KQ + + KS G
Sbjct: 147 YHSLALSKASEVFCWGQNKYGQLGLGTDCK----------------KQTSPQLLKSLLG- 189
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
+ + ++ G H+ + F WG FG+LG ++ D VP L+K +
Sbjct: 190 ------IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS-- 241
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV-- 397
+ + + CG ++ A+ +G +F F GQ ++ + P+ V +L G + +
Sbjct: 242 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIAC 301
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G +TS + + + ++G+ G+LG G
Sbjct: 302 GRQHTSAFVPSSGRIYSFGLGGN-GQLGTG 330
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 295
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 296 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 93.5 bits (222), Expect = 1e-18
Identities = 91/334 (27%), Positives = 144/334 (43%), Gaps = 43/334 (12%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G + KP ++ + IV V CG ++ L+ G ++++G+ GQLG
Sbjct: 64 GQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG--- 117
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
V S + +P+ I KS + D+ IV ++CG H++A+
Sbjct: 118 ----LVGSEECI----RVPRNI-----KS-------LSDIQIVQVACGYYHSLALSKASE 157
Query: 313 AFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF--- 368
F WG +G+LG + K + P+L+K +G V GG +S + GA+F
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 369 --MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGE 423
FGQ E + Y P + L I + G +T+ + + + +G YG+
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG-GYGQ 273
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
LG + P++V + +T++A G HT
Sbjct: 274 LGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 306
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 42/285 (14%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
GQLGH K P+Q+ ++ IV +SCG HT
Sbjct: 63 LGQLGHEKSRKK--------------PEQVVALDAQN------------IVAVSCGEAHT 96
Query: 305 VAIDSMKRAFSWGFGGFGRLGHAEQKD-ENVPRLIKYFDTVGRGVRSVHCGGTYSLAVND 363
+A++ + ++WG G+LG ++ VPR IK + + V CG +SLA++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSK 154
Query: 364 QGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAW 415
+F +GQ K + G + P+ + L G V S V+ ++ W
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
G + +G+LG+ + N P + + S I + G HT L
Sbjct: 215 GRN-KFGQLGLNDENDRYV-PNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 299
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 34.7 bits (76), Expect = 0.73
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 394 IKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
++ VG V DD + G+LG KS KP++V +D+ I V+ G
Sbjct: 36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPEQVVALDAQNIVAVSCG 92
Query: 454 YSHTLLLCD 462
+HTL L D
Sbjct: 93 EAHTLALND 101
>AL133551-3|CAI16032.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 117 bits (282), Expect = 8e-26
Identities = 97/330 (29%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNI 166
F ++R R + GC H+V V ++G YT G N GQLG + R PE V L +NI
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQNI 86
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA 225
+ + G HTL + D G VYA G + GQ GL + I P IK + IV+V CG
Sbjct: 87 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY 146
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
S+ L + +G +YGQLG TD K KQ + + KS G
Sbjct: 147 YHSLALSKASEVFCWGQNKYGQLGLGTDCK----------------KQTSPQLLKSLLG- 189
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
+ + ++ G H+ + F WG FG+LG ++ D VP L+K +
Sbjct: 190 ------IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS-- 241
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV-- 397
+ + + CG ++ A+ +G +F F GQ ++ + P+ V +L G + +
Sbjct: 242 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIAC 301
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G +TS + + + ++G+ G+LG G
Sbjct: 302 GRQHTSAFVPSSGRIYSFGLGGN-GQLGTG 330
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 295
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 296 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 93.5 bits (222), Expect = 1e-18
Identities = 91/334 (27%), Positives = 144/334 (43%), Gaps = 43/334 (12%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G + KP ++ + IV V CG ++ L+ G ++++G+ GQLG
Sbjct: 64 GQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG--- 117
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
V S + +P+ I KS + D+ IV ++CG H++A+
Sbjct: 118 ----LVGSEECI----RVPRNI-----KS-------LSDIQIVQVACGYYHSLALSKASE 157
Query: 313 AFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF--- 368
F WG +G+LG + K + P+L+K +G V GG +S + GA+F
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 369 --MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGE 423
FGQ E + Y P + L I + G +T+ + + + +G YG+
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG-GYGQ 273
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
LG + P++V + +T++A G HT
Sbjct: 274 LGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 306
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 42/285 (14%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
GQLGH K P+Q+ ++ IV +SCG HT
Sbjct: 63 LGQLGHEKSRKK--------------PEQVVALDAQN------------IVAVSCGEAHT 96
Query: 305 VAIDSMKRAFSWGFGGFGRLGHAEQKD-ENVPRLIKYFDTVGRGVRSVHCGGTYSLAVND 363
+A++ + ++WG G+LG ++ VPR IK + + V CG +SLA++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSK 154
Query: 364 QGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAW 415
+F +GQ K + G + P+ + L G V S V+ ++ W
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
G + +G+LG+ + N P + + S I + G HT L
Sbjct: 215 GRN-KFGQLGLNDENDRYV-PNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 299
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 300 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 34.7 bits (76), Expect = 0.73
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 394 IKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
++ VG V DD + G+LG KS KP++V +D+ I V+ G
Sbjct: 36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPEQVVALDAQNIVAVSCG 92
Query: 454 YSHTLLLCD 462
+HTL L D
Sbjct: 93 EAHTLALND 101
>AF071172-1|AAD08657.1| 4834|Homo sapiens HERC2 protein.
Length = 4834
Score = 115 bits (277), Expect = 3e-25
Identities = 95/343 (27%), Positives = 159/343 (46%), Gaps = 39/343 (11%)
Query: 127 VSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV--GRHHTLFVTDTGC 184
V+ +G+ Y G A G+LG G T + S P L+ ++ I AV G H L ++ G
Sbjct: 4000 VTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE 4059
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPE 244
VY+ G+ + G+ G GN +P G +V V G S + G+L+++G
Sbjct: 4060 VYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGR 4119
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN-- 302
YG+LGH+ + +L PK + ++ G+ +VD++CG+
Sbjct: 4120 YGRLGHSD------SEDQLK------PKLV-----EALQGH-------RVVDIACGSGDA 4155
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
T+ + +SWG G +G+LG VP +K G GV V CG +S+A+
Sbjct: 4156 QTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVP--MKIDSLTGLGVVKVECGSQFSVALT 4213
Query: 363 DQGALFMFGQTK--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AW 415
GA++ +G+ R G + P+ V L G + ++ T + V +D + W
Sbjct: 4214 KSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTW 4273
Query: 416 GVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
G + G+LG G N + +P+ V+ + + +VA G +HTL
Sbjct: 4274 GDNDE-GQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTL 4314
Score = 106 bits (255), Expect = 1e-22
Identities = 97/346 (28%), Positives = 161/346 (46%), Gaps = 44/346 (12%)
Query: 127 VSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV---GRHHTLFVTDT 182
V+ EG+ Y G G+LG G + T +P + L + AV GRH T D
Sbjct: 3007 VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVD- 3065
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFG 241
G V++ G+ G+ G + KP I+ T ++ + CG+ S L +G L+++G
Sbjct: 3066 GKVFSWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWG 3124
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+ EYG+LGH + +T+L PK + + + G+ ++ ++CG+
Sbjct: 3125 LGEYGRLGHGDN------TTQLK------PKMVKVLL-----GH-------RVIQVACGS 3160
Query: 302 N--HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
T+A+ FSWG G FG+LG + N+P+ I+ + G+GV + CG +SL
Sbjct: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN--GQGVCQIECGAQFSL 3218
Query: 360 AVNDQGALFMFGQTK--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI 413
A+ G ++ +G+ R G + P+ V L G I V + D +
Sbjct: 3219 ALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQV 3278
Query: 414 -AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
AWG + +G+ G G + KP V ++ IT+VA G SH++
Sbjct: 3279 YAWGDND-HGQQGNGTTTVNR-KPTLVQGLEGQKITRVACGSSHSV 3322
Score = 104 bits (249), Expect = 8e-22
Identities = 90/350 (25%), Positives = 153/350 (43%), Gaps = 53/350 (15%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR--HHT 176
C +++S G YT N+ DT+ P+LV L +NI+ A HH
Sbjct: 458 CAEKRFLILSRNGRVYTQAYNS-------DTLA---PQLVQGLASRNIVKIAAHSDGHHY 507
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTP----QILKPTRIKYNGTPIVKVGCGAEFSMILD 232
L + TG VY+ G G+ G G+T P +++ K G +V + CG+ +S +
Sbjct: 508 LALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAIT 567
Query: 233 CNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDV 292
G L+++G YG+LGH S E IP + +K +
Sbjct: 568 AEGELYTWGRGNYGRLGHG------------SSEDEAIPM------------LVAGLKGL 603
Query: 293 TIVDLSCGNN--HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
++D++CG+ T+A+ + +SWG G +G+LG P+LI+ + V
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDL--DVVK 661
Query: 351 VHCGGTYSLAVNDQGALFMFGQ--TKRTG----EANMYPKPVHDLTGWNIKSVGTSNTSI 404
V CG +S+A+ G ++ +G+ +R G E YPK + L G + V +T
Sbjct: 662 VRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHC 721
Query: 405 VIAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
+ +DS + +WG + + K +P + +D+ I +A G
Sbjct: 722 LALTEDSEVHSWGSNDQCQHFDTLRVTK--PEPAALPGLDTKHIVGIACG 769
Score = 104 bits (249), Expect = 8e-22
Identities = 93/344 (27%), Positives = 149/344 (43%), Gaps = 40/344 (11%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN 191
+ + +G N QLG VP L N++ A G VT G VYACG+
Sbjct: 2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019
Query: 192 KSGQCGLGNTTPQILKPTRIKYNGTPIVK---VGCGAEFSMILDCNGNLHSFGMPEYGQL 248
+G+ GLG ++ + P +I + +VK V G + L +G + S+G + G+L
Sbjct: 3020 TNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKL 3079
Query: 249 GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAID 308
G HF + K I +K I D++CG++H+ A+
Sbjct: 3080 G----------------HFSRM--------NCDKPRLIEALKTKRIRDIACGSSHSAALT 3115
Query: 309 SMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG--TYSLAVNDQGA 366
S ++WG G +GRLGH + + P+++K +G V V CG +LA+ D+G
Sbjct: 3116 SSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVL--LGHRVIQVACGSRDAQTLALTDEGL 3173
Query: 367 LFM-----FGQTKRTG-EANMYPKPVHDLTGWNIKSVGT-SNTSIVIAADDSLIAWGVSP 419
+F FG+ R G E P+ + L G + + + S+ + + WG
Sbjct: 3174 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWG-KG 3232
Query: 420 TYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
Y LG G + KP+ V + I VA+G H L + D+
Sbjct: 3233 DYFRLGHGS-DVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDS 3275
Score = 101 bits (241), Expect = 7e-21
Identities = 65/244 (26%), Positives = 118/244 (48%), Gaps = 28/244 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH--HT 176
C + HS ++ GE YT+G G+LG GD T+ P++V L G +I A G T
Sbjct: 3106 CGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQT 3165
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
L +TD G V++ GD G+ G G + + + NG + ++ CGA+FS+ L +G
Sbjct: 3166 LALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGV 3225
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
+ ++G +Y +LGH +D ++++K + + ++ IV
Sbjct: 3226 VWTWGKGDYFRLGHGSD----------------------VHVRKPQ--VVEGLRGKKIVH 3261
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGT 356
++ G H +A+ + ++WG G+ G+ P L++ + G+ + V CG +
Sbjct: 3262 VAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE--GQKITRVACGSS 3319
Query: 357 YSLA 360
+S+A
Sbjct: 3320 HSVA 3323
Score = 90.2 bits (214), Expect = 1e-17
Identities = 67/240 (27%), Positives = 111/240 (46%), Gaps = 28/240 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH--HTLFVT 180
HS V+ G+ YT+G+ G+LG D+ + P+LV L+G ++ A G TL +T
Sbjct: 4102 HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLT 4161
Query: 181 DTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSF 240
D V++ GD G+ G G + + G +VKV CG++FS+ L +G ++++
Sbjct: 4162 DDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTW 4221
Query: 241 GMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCG 300
G +Y +LGH +D H P+Q+ +Q K ++ ++ G
Sbjct: 4222 GKGDYHRLGHGSDD-----------HVRR-PRQVQ-GLQGKK-----------VIAIATG 4257
Query: 301 NNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA 360
+ H V ++WG G+LG PRL+ G+ V V CG ++LA
Sbjct: 4258 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQ--GKKVNRVACGSAHTLA 4315
Score = 82.6 bits (195), Expect = 3e-15
Identities = 62/253 (24%), Positives = 115/253 (45%), Gaps = 32/253 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H + +S EGE Y++G G+LG G+ P ++ L+G ++ A G H+ VT
Sbjct: 4050 HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAA 4109
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGA--EFSMILDCNGNLHS 239
G +Y G + G+ G ++ Q LKP ++ G +V + CG+ ++ L + + S
Sbjct: 4110 GDLYTWGKGRYGRLGHSDSEDQ-LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWS 4168
Query: 240 FGMPEYGQLGH-NTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLS 298
+G +YG+LG +DG +P + I + + +V +
Sbjct: 4169 WGDGDYGKLGRGGSDGC-------------KVPMK------------IDSLTGLGVVKVE 4203
Query: 299 CGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
CG+ +VA+ ++WG G + RLGH PR ++ G+ V ++ G +
Sbjct: 4204 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQ--GKKVIAIATGSLHC 4261
Query: 359 LAVNDQGALFMFG 371
+ + G ++ +G
Sbjct: 4262 VCCTEDGEVYTWG 4274
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 23/205 (11%)
Query: 270 IPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ 329
IP+QIT + Y+ VK V + G H A+ + FSWG G G+LGH +
Sbjct: 3035 IPRQIT-----ALSSYV--VKKVAV---HSGGRHATALTVDGKVFSWGEGDDGKLGHFSR 3084
Query: 330 KDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMF--GQTKRTGEAN----MYP 383
+ + PRLI+ T + +R + CG ++S A+ G L+ + G+ R G + + P
Sbjct: 3085 MNCDKPRLIEALKT--KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKP 3142
Query: 384 KPVHDLTGWNIKSV--GTSNTSIVIAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVS 440
K V L G + V G+ + + D+ L+ +WG +G+LG G ++ P+ +
Sbjct: 3143 KMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG-DGDFGKLGRGG-SEGCNIPQNIE 3200
Query: 441 RMDSLGITQVAMGYSHTLLLCDNNI 465
R++ G+ Q+ G +L L + +
Sbjct: 3201 RLNGQGVCQIECGAQFSLALTKSGV 3225
Score = 69.3 bits (162), Expect = 3e-11
Identities = 50/180 (27%), Positives = 84/180 (46%), Gaps = 13/180 (7%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
+V ++CG+ ++ AI + ++WG G +GRLGH +DE +P L+ G V V C
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVA--GLKGLKVIDVAC 610
Query: 354 GG--TYSLAVNDQGALFM-----FGQTKRTG-EANMYPKPVHDLTGWNIKSVGT-SNTSI 404
G +LAV + G ++ +G+ R G + PK + L ++ V S SI
Sbjct: 611 GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSI 670
Query: 405 VIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
+ D + +WG LG G + PK + + + VA G +H L L +++
Sbjct: 671 ALTKDGQVYSWGKGDNQ-RLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
Score = 66.9 bits (156), Expect = 1e-10
Identities = 47/170 (27%), Positives = 77/170 (45%), Gaps = 13/170 (7%)
Query: 302 NHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH--CGGTYSL 359
+H +A+ + +SWG G GRLGH + P++I F G VH CG TYS
Sbjct: 505 HHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSA 564
Query: 360 AVNDQGALFMFGQTK--RTG----EANMYPKPVHDLTGWNIKSVGTSN---TSIVIAADD 410
A+ +G L+ +G+ R G E P V L G + V + ++ + +
Sbjct: 565 AITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENG 624
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ +WG YG+LG G + PK + ++ L + +V G ++ L
Sbjct: 625 QVWSWG-DGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKVRCGSQFSIAL 672
Score = 64.5 bits (150), Expect = 8e-10
Identities = 39/130 (30%), Positives = 69/130 (53%), Gaps = 4/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H+ ++ +G+ +++G G+LG + P L+ LK K I A G H+ +T +
Sbjct: 3058 HATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSS 3117
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAE--FSMILDCNGNLHS 239
G +Y G + G+ G G+ T Q LKP +K G +++V CG+ ++ L G + S
Sbjct: 3118 GELYTWGLGEYGRLGHGDNTTQ-LKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 3176
Query: 240 FGMPEYGQLG 249
+G ++G+LG
Sbjct: 3177 WGDGDFGKLG 3186
Score = 63.7 bits (148), Expect = 1e-09
Identities = 38/112 (33%), Positives = 56/112 (50%), Gaps = 2/112 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + SV +++ G YT+G+ +LG G P V L+GK +I A G H +
Sbjct: 4204 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVC 4263
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSM 229
T+ G VY GDN GQ G G TT I +P + G + +V CG+ ++
Sbjct: 4264 CTEDGEVYTWGDNDEGQLGDG-TTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314
Score = 59.7 bits (138), Expect = 2e-08
Identities = 46/175 (26%), Positives = 81/175 (46%), Gaps = 11/175 (6%)
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
V L G A+ + + ++ G+G GRLG + + P L++ V +V+ G
Sbjct: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 4047
Query: 355 GTYSLAVNDQGALFMFGQTK--RTGEANM----YPKPVHDLTGWNIKSV--GTSNTSIVI 406
G + LA++ +G ++ +G+ + + G N P+ + L G + V G ++++ V
Sbjct: 4048 GKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVT 4107
Query: 407 AADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLC 461
AA D L WG YG LG + ++ KPK V + + +A G LC
Sbjct: 4108 AAGD-LYTWG-KGRYGRLGHSD-SEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
Score = 57.2 bits (132), Expect = 1e-07
Identities = 33/139 (23%), Positives = 69/139 (49%), Gaps = 2/139 (1%)
Query: 115 IVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH 174
+ G ++ +++EG +++G G+LG G + ++P+ + L G+ + G
Sbjct: 3156 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 3215
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDC 233
+L +T +G V+ G + G G+ + KP ++ G IV V GA + +
Sbjct: 3216 FSLALTKSGVVWTWGKGDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTD 3274
Query: 234 NGNLHSFGMPEYGQLGHNT 252
+G ++++G ++GQ G+ T
Sbjct: 3275 SGQVYAWGDNDHGQQGNGT 3293
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 131 GEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF-VTDTGCVYACG 189
G Y +G N GQLG + VP L + +G TLF VT G +YA G
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATG 4010
Query: 190 DNKSGQCGLGNT----TPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
G+ G+G T TP +L+ I++ V V G + + L G ++S+G E
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLE--SIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAED 4068
Query: 246 GQLGH 250
G+LGH
Sbjct: 4069 GKLGH 4073
Score = 51.2 bits (117), Expect = 8e-06
Identities = 29/128 (22%), Positives = 62/128 (48%), Gaps = 2/128 (1%)
Query: 115 IVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH 174
+ G ++ V+E G+ +++G G+LG G + P+L+ +L+ +++ G
Sbjct: 608 VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQ 667
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDC 233
++ +T G VY+ G + + G G T + P ++ G ++ V G+ + L
Sbjct: 668 FSIALTKDGQVYSWGKGDNQRLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTE 726
Query: 234 NGNLHSFG 241
+ +HS+G
Sbjct: 727 DSEVHSWG 734
Score = 50.8 bits (116), Expect = 1e-05
Identities = 30/144 (20%), Positives = 70/144 (48%), Gaps = 4/144 (2%)
Query: 112 YRLIVSGCTAG--HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
+R++ C +G ++ ++++ +++G G+LG G + VP + L G ++
Sbjct: 4143 HRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKV 4202
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFS 228
G ++ +T +G VY G + G G + + +P +++ G ++ + G+
Sbjct: 4203 ECGSQFSVALTKSGAVYTWGKGDYHRLGHG-SDDHVRRPRQVQGLQGKKVIAIATGSLHC 4261
Query: 229 MILDCNGNLHSFGMPEYGQLGHNT 252
+ +G ++++G + GQLG T
Sbjct: 4262 VCCTEDGEVYTWGDNDEGQLGDGT 4285
>D25215-1|BAA04945.2| 1054|Homo sapiens KIAA0032 protein.
Length = 1054
Score = 112 bits (270), Expect = 2e-24
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 37/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HSV + E+GE YT G N GQLG + PE + L ++IIH A G H+L
Sbjct: 45 CGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLA 102
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNL 237
++D G +++ G GQ GL T + P I K N I++V CG + L +G
Sbjct: 103 LSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 162
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++G +GQLG GK F P Q + +S +G + + +
Sbjct: 163 FTWGKNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQV 199
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
+ G H+ A+ F WG G+LG +++KD P +K T + V + CG +
Sbjct: 200 AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT--QKVVYISCGEEH 257
Query: 358 SLAVNDQGALFMF--GQTKRTGEANM----YPKPVHDLTGWNIKSV--GTSNTSIVIAAD 409
+ + G +F F G + G +M P+ V +L G + + G +T + +
Sbjct: 258 TAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSS 317
Query: 410 DSLIAWGVSPTYGELGMG 427
+ A+G G+LG G
Sbjct: 318 GLIYAFGCG-ARGQLGTG 334
Score = 107 bits (256), Expect = 1e-22
Identities = 74/261 (28%), Positives = 116/261 (44%), Gaps = 29/261 (11%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHAAVG 172
+I C HS+ +S+ G+ +++G + GQLG T +VP L+ +L + I+ + G
Sbjct: 90 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 149
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMIL 231
H L + G + G N GQ GLG P P R++ G P+ +V G S L
Sbjct: 150 NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 209
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
+G + +GM GQLG + + + H + + Q +YI
Sbjct: 210 SLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVVYI------------- 251
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
SCG HT + F++G G G+LGH DE PR + + +G V +
Sbjct: 252 ------SCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPR--RVLELMGSEVTQI 303
Query: 352 HCGGTYSLA-VNDQGALFMFG 371
CG ++LA V G ++ FG
Sbjct: 304 ACGRQHTLAFVPSSGLIYAFG 324
Score = 80.6 bits (190), Expect = 1e-14
Identities = 89/336 (26%), Positives = 148/336 (44%), Gaps = 45/336 (13%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQ G + V P++ + +++ A G +H++F+ + G VY CG N
Sbjct: 8 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 67
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G KP +I I+ V CG S+ L G L S+G GQLG T
Sbjct: 68 GQLGHEREGN---KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 124
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
T ++ +P+ IQK + TI+ +SCGN H +A+ + +
Sbjct: 125 ------TEDSVA-----VPR----LIQK--------LNQQTILQVSCGNWHCLALAADGQ 161
Query: 313 AFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFG 371
F+WG G+LG ++ + P+ ++ + G + V GG +S A++ GA+F +G
Sbjct: 162 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLE--GIPLAQVAAGGAHSFALSLSGAVFGWG 219
Query: 372 QTKRTGEANMYPK-----PVHDLTGWNIK----SVGTSNTSIVIAADDSLIAWGVSPTYG 422
G+ + + P H K S G +T+ V+ + +G + G
Sbjct: 220 MNN-AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTA-VLTKSGGVFTFGAG-SCG 276
Query: 423 ELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+LG +N P+ V + +TQ+A G HTL
Sbjct: 277 QLGHDSMNDEV-NPRRVLELMGSEVTQIACGRQHTL 311
Score = 78.2 bits (184), Expect = 6e-14
Identities = 50/180 (27%), Positives = 91/180 (50%), Gaps = 13/180 (7%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGV 348
+ D ++ +++CG NH+V + ++ G G+LGH +++ N P I + +
Sbjct: 35 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGAL--ADQHI 90
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQ-------TKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V CG ++SLA++D+G LF +G T ++ P+ + L I V N
Sbjct: 91 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 150
Query: 402 -TSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ +AAD WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 151 WHCLALAADGQFFTWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 209
Score = 72.1 bits (169), Expect = 4e-12
Identities = 62/252 (24%), Positives = 110/252 (43%), Gaps = 39/252 (15%)
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
+ +V CG S+ L +G +++ G+ GQLGH +G P+QI
Sbjct: 40 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--------------PEQIGA- 84
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPR 336
+ D I+ ++CG +H++A+ + FSWG G G+LG +D VPR
Sbjct: 85 -----------LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR 133
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK-------RTGEANMYPKPVHDL 389
LI+ + + + V CG + LA+ G F +G+ + + P+ V L
Sbjct: 134 LIQKLNQ--QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSL 191
Query: 390 TGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGIT 448
G + V S ++ ++ WG++ G+LG+ + K P V + + +
Sbjct: 192 EGIPLAQVAAGGAHSFALSLSGAVFGWGMN-NAGQLGLSD-EKDRESPCHVKLLRTQKVV 249
Query: 449 QVAMGYSHTLLL 460
++ G HT +L
Sbjct: 250 YISCGEEHTAVL 261
Score = 68.9 bits (161), Expect = 4e-11
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ ++++ G +TFG +CGQLG P V EL G +
Sbjct: 244 RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQI 303
Query: 170 AVGRHHTL-FVTDTGCVYACGDNKSGQCGLGNT 201
A GR HTL FV +G +YA G GQ G G+T
Sbjct: 304 ACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 336
>BC038960-1|AAH38960.1| 368|Homo sapiens HERC3 protein protein.
Length = 368
Score = 112 bits (270), Expect = 2e-24
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 37/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HSV + E+GE YT G N GQLG + PE + L ++IIH A G H+L
Sbjct: 41 CGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLA 98
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNL 237
++D G +++ G GQ GL T + P I K N I++V CG + L +G
Sbjct: 99 LSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 158
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++G +GQLG GK F P Q + +S +G + + +
Sbjct: 159 FTWGKNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQV 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
+ G H+ A+ F WG G+LG +++KD P +K T + V + CG +
Sbjct: 196 AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT--QKVVYISCGEEH 253
Query: 358 SLAVNDQGALFMF--GQTKRTGEANM----YPKPVHDLTGWNIKSV--GTSNTSIVIAAD 409
+ + G +F F G + G +M P+ V +L G + + G +T + +
Sbjct: 254 TAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSS 313
Query: 410 DSLIAWGVSPTYGELGMG 427
+ A+G G+LG G
Sbjct: 314 GLIYAFGCG-ARGQLGTG 330
Score = 107 bits (256), Expect = 1e-22
Identities = 74/261 (28%), Positives = 116/261 (44%), Gaps = 29/261 (11%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHAAVG 172
+I C HS+ +S+ G+ +++G + GQLG T +VP L+ +L + I+ + G
Sbjct: 86 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMIL 231
H L + G + G N GQ GLG P P R++ G P+ +V G S L
Sbjct: 146 NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
+G + +GM GQLG + + + H + + Q +YI
Sbjct: 206 SLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVVYI------------- 247
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
SCG HT + F++G G G+LGH DE PR + + +G V +
Sbjct: 248 ------SCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPR--RVLELMGSEVTQI 299
Query: 352 HCGGTYSLA-VNDQGALFMFG 371
CG ++LA V G ++ FG
Sbjct: 300 ACGRQHTLAFVPSSGLIYAFG 320
Score = 80.6 bits (190), Expect = 1e-14
Identities = 89/336 (26%), Positives = 148/336 (44%), Gaps = 45/336 (13%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQ G + V P++ + +++ A G +H++F+ + G VY CG N
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G KP +I I+ V CG S+ L G L S+G GQLG T
Sbjct: 64 GQLGHEREGN---KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
T ++ +P+ IQK + TI+ +SCGN H +A+ + +
Sbjct: 121 ------TEDSVA-----VPR----LIQK--------LNQQTILQVSCGNWHCLALAADGQ 157
Query: 313 AFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFG 371
F+WG G+LG ++ + P+ ++ + G + V GG +S A++ GA+F +G
Sbjct: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLE--GIPLAQVAAGGAHSFALSLSGAVFGWG 215
Query: 372 QTKRTGEANMYPK-----PVHDLTGWNIK----SVGTSNTSIVIAADDSLIAWGVSPTYG 422
G+ + + P H K S G +T+ V+ + +G + G
Sbjct: 216 MNN-AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTA-VLTKSGGVFTFGAG-SCG 272
Query: 423 ELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+LG +N P+ V + +TQ+A G HTL
Sbjct: 273 QLGHDSMNDEV-NPRRVLELMGSEVTQIACGRQHTL 307
Score = 78.2 bits (184), Expect = 6e-14
Identities = 50/180 (27%), Positives = 91/180 (50%), Gaps = 13/180 (7%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGV 348
+ D ++ +++CG NH+V + ++ G G+LGH +++ N P I + +
Sbjct: 31 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGAL--ADQHI 86
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQ-------TKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V CG ++SLA++D+G LF +G T ++ P+ + L I V N
Sbjct: 87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 146
Query: 402 -TSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ +AAD WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 147 WHCLALAADGQFFTWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Score = 72.1 bits (169), Expect = 4e-12
Identities = 62/252 (24%), Positives = 110/252 (43%), Gaps = 39/252 (15%)
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
+ +V CG S+ L +G +++ G+ GQLGH +G P+QI
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--------------PEQIGA- 80
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPR 336
+ D I+ ++CG +H++A+ + FSWG G G+LG +D VPR
Sbjct: 81 -----------LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR 129
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK-------RTGEANMYPKPVHDL 389
LI+ + + + V CG + LA+ G F +G+ + + P+ V L
Sbjct: 130 LIQKLNQ--QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSL 187
Query: 390 TGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGIT 448
G + V S ++ ++ WG++ G+LG+ + K P V + + +
Sbjct: 188 EGIPLAQVAAGGAHSFALSLSGAVFGWGMN-NAGQLGLSD-EKDRESPCHVKLLRTQKVV 245
Query: 449 QVAMGYSHTLLL 460
++ G HT +L
Sbjct: 246 YISCGEEHTAVL 257
Score = 68.9 bits (161), Expect = 4e-11
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ ++++ G +TFG +CGQLG P V EL G +
Sbjct: 240 RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQI 299
Query: 170 AVGRHHTL-FVTDTGCVYACGDNKSGQCGLGNT 201
A GR HTL FV +G +YA G GQ G G+T
Sbjct: 300 ACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
>AC098582-1|AAY41038.1| 382|Homo sapiens unknown protein.
Length = 382
Score = 112 bits (270), Expect = 2e-24
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 37/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HSV + E+GE YT G N GQLG + PE + L ++IIH A G H+L
Sbjct: 41 CGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLA 98
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNL 237
++D G +++ G GQ GL T + P I K N I++V CG + L +G
Sbjct: 99 LSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 158
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++G +GQLG GK F P Q + +S +G + + +
Sbjct: 159 FTWGKNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQV 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
+ G H+ A+ F WG G+LG +++KD P +K T + V + CG +
Sbjct: 196 AAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT--QKVVYISCGEEH 253
Query: 358 SLAVNDQGALFMF--GQTKRTGEANM----YPKPVHDLTGWNIKSV--GTSNTSIVIAAD 409
+ + G +F F G + G +M P+ V +L G + + G +T + +
Sbjct: 254 TAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSS 313
Query: 410 DSLIAWGVSPTYGELGMG 427
+ A+G G+LG G
Sbjct: 314 GLIYAFGCG-ARGQLGTG 330
Score = 107 bits (256), Expect = 1e-22
Identities = 74/261 (28%), Positives = 116/261 (44%), Gaps = 29/261 (11%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHAAVG 172
+I C HS+ +S+ G+ +++G + GQLG T +VP L+ +L + I+ + G
Sbjct: 86 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMIL 231
H L + G + G N GQ GLG P P R++ G P+ +V G S L
Sbjct: 146 NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
+G + +GM GQLG + + + H + + Q +YI
Sbjct: 206 SLSGAVFGWGMNNAGQLGLSDE-----KDRESPCHVKLLRTQKVVYI------------- 247
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
SCG HT + F++G G G+LGH DE PR + + +G V +
Sbjct: 248 ------SCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPR--RVLELMGSEVTQI 299
Query: 352 HCGGTYSLA-VNDQGALFMFG 371
CG ++LA V G ++ FG
Sbjct: 300 ACGRQHTLAFVPSSGLIYAFG 320
Score = 80.6 bits (190), Expect = 1e-14
Identities = 89/336 (26%), Positives = 148/336 (44%), Gaps = 45/336 (13%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQ G + V P++ + +++ A G +H++F+ + G VY CG N
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 194 GQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GQ G KP +I I+ V CG S+ L G L S+G GQLG T
Sbjct: 64 GQLGHEREGN---KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
T ++ +P+ IQK + TI+ +SCGN H +A+ + +
Sbjct: 121 ------TEDSVA-----VPR----LIQK--------LNQQTILQVSCGNWHCLALAADGQ 157
Query: 313 AFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFG 371
F+WG G+LG ++ + P+ ++ + G + V GG +S A++ GA+F +G
Sbjct: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLE--GIPLAQVAAGGAHSFALSLSGAVFGWG 215
Query: 372 QTKRTGEANMYPK-----PVHDLTGWNIK----SVGTSNTSIVIAADDSLIAWGVSPTYG 422
G+ + + P H K S G +T+ V+ + +G + G
Sbjct: 216 MNN-AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTA-VLTKSGGVFTFGAG-SCG 272
Query: 423 ELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+LG +N P+ V + +TQ+A G HTL
Sbjct: 273 QLGHDSMNDEV-NPRRVLELMGSEVTQIACGRQHTL 307
Score = 78.2 bits (184), Expect = 6e-14
Identities = 50/180 (27%), Positives = 91/180 (50%), Gaps = 13/180 (7%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGV 348
+ D ++ +++CG NH+V + ++ G G+LGH +++ N P I + +
Sbjct: 31 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGAL--ADQHI 86
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQ-------TKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V CG ++SLA++D+G LF +G T ++ P+ + L I V N
Sbjct: 87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 146
Query: 402 -TSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ +AAD WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 147 WHCLALAADGQFFTWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Score = 72.1 bits (169), Expect = 4e-12
Identities = 62/252 (24%), Positives = 110/252 (43%), Gaps = 39/252 (15%)
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
+ +V CG S+ L +G +++ G+ GQLGH +G P+QI
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--------------PEQIGA- 80
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPR 336
+ D I+ ++CG +H++A+ + FSWG G G+LG +D VPR
Sbjct: 81 -----------LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR 129
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK-------RTGEANMYPKPVHDL 389
LI+ + + + V CG + LA+ G F +G+ + + P+ V L
Sbjct: 130 LIQKLNQ--QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSL 187
Query: 390 TGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGIT 448
G + V S ++ ++ WG++ G+LG+ + K P V + + +
Sbjct: 188 EGIPLAQVAAGGAHSFALSLSGAVFGWGMN-NAGQLGLSD-EKDRESPCHVKLLRTQKVV 245
Query: 449 QVAMGYSHTLLL 460
++ G HT +L
Sbjct: 246 YISCGEEHTAVL 257
Score = 68.9 bits (161), Expect = 4e-11
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ ++++ G +TFG +CGQLG P V EL G +
Sbjct: 240 RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQI 299
Query: 170 AVGRHHTL-FVTDTGCVYACGDNKSGQCGLGNT 201
A GR HTL FV +G +YA G GQ G G+T
Sbjct: 300 ACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
>AF224249-1|AAO27475.1| 328|Homo sapiens HERC2 protein.
Length = 328
Score = 99 bits (238), Expect = 2e-20
Identities = 92/340 (27%), Positives = 146/340 (42%), Gaps = 40/340 (11%)
Query: 136 FGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQ 195
+G N QLG VP L N++ A G VT G VYACG+ +G+
Sbjct: 2 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGR 61
Query: 196 CGLGNTTPQILKPTRIKYNGTPIVK---VGCGAEFSMILDCNGNLHSFGMPEYGQLGHNT 252
GLG ++ + P +I + +VK V G + L +G + +G + G+LG
Sbjct: 62 LGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFWWGEGDDGKLG--- 118
Query: 253 DGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKR 312
HF + K I +K I D++CG++H+ A+ S
Sbjct: 119 -------------HFSRM--------NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 157
Query: 313 AFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG--TYSLAVNDQGALFM- 369
++WG G +GRLGH + + P+++K +G V V CG +LA+ D+G +F
Sbjct: 158 LYTWGLGEYGRLGHGDNTTQLKPKMVKVL--LGHRVIQVACGSRDAQTLALTDEGLVFSW 215
Query: 370 ----FGQTKRTG-EANMYPKPVHDLTGWNIKSVGT-SNTSIVIAADDSLIAWGVSPTYGE 423
FG+ R G E P+ + L G + + + S+ + + WG Y
Sbjct: 216 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWG-KGDYFR 274
Query: 424 LGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
LG G + KP+ V + I VA+G H L + D+
Sbjct: 275 LGHGS-DVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDS 313
Score = 93.1 bits (221), Expect = 2e-18
Identities = 47/137 (34%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH--HT 176
C + HS ++ GE YT+G G+LG GD T+ P++V L G +I A G T
Sbjct: 144 CGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQT 203
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
L +TD G V++ GD G+ G G + + + NG + ++ CGA+FS+ L +G
Sbjct: 204 LALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGV 263
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++G +Y +LGH +D
Sbjct: 264 VWTWGKGDYFRLGHGSD 280
Score = 91.5 bits (217), Expect = 6e-18
Identities = 84/304 (27%), Positives = 138/304 (45%), Gaps = 42/304 (13%)
Query: 127 VSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV---GRHHTLFVTDT 182
V+ EG+ Y G G+LG G + T +P + L + AV GRH T D
Sbjct: 45 VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVD- 103
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFG 241
G V+ G+ G+ G + KP I+ T ++ + CG+ S L +G L+++G
Sbjct: 104 GKVFWWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWG 162
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+ EYG+LGH + +T+L PK + + + G+ ++ ++CG+
Sbjct: 163 LGEYGRLGHGDN------TTQLK------PKMVKVLL-----GH-------RVIQVACGS 198
Query: 302 N--HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
T+A+ FSWG G FG+LG + N+P+ I+ + G+GV + CG +SL
Sbjct: 199 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN--GQGVCQIECGAQFSL 256
Query: 360 AVNDQGALFMFGQTK--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI 413
A+ G ++ +G+ R G + P+ V L G I V + D +
Sbjct: 257 ALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQV 316
Query: 414 -AWG 416
AWG
Sbjct: 317 YAWG 320
Score = 72.5 bits (170), Expect = 3e-12
Identities = 57/205 (27%), Positives = 99/205 (48%), Gaps = 23/205 (11%)
Query: 270 IPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ 329
IP+QIT + Y+ VK V + G H A+ + F WG G G+LGH +
Sbjct: 73 IPRQIT-----ALSSYV--VKKVAV---HSGGRHATALTVDGKVFWWGEGDDGKLGHFSR 122
Query: 330 KDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMF--GQTKRTGEAN----MYP 383
+ + PRLI+ T + +R + CG ++S A+ G L+ + G+ R G + + P
Sbjct: 123 MNCDKPRLIEALKT--KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKP 180
Query: 384 KPVHDLTGWNIKSV--GTSNTSIVIAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVS 440
K V L G + V G+ + + D+ L+ +WG +G+LG G ++ P+ +
Sbjct: 181 KMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG-DGDFGKLGRGG-SEGCNIPQNIE 238
Query: 441 RMDSLGITQVAMGYSHTLLLCDNNI 465
R++ G+ Q+ G +L L + +
Sbjct: 239 RLNGQGVCQIECGAQFSLALTKSGV 263
Score = 69.7 bits (163), Expect = 2e-11
Identities = 35/79 (44%), Positives = 48/79 (60%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C A S+ +++ G +T+G+ +LG G V P++V L+GK I+H AVG H L
Sbjct: 250 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA 309
Query: 179 VTDTGCVYACGDNKSGQCG 197
VTD+G VYA GDN GQ G
Sbjct: 310 VTDSGQVYAWGDNDHGQQG 328
Score = 63.3 bits (147), Expect = 2e-09
Identities = 39/130 (30%), Positives = 68/130 (52%), Gaps = 4/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H+ ++ +G+ + +G G+LG + P L+ LK K I A G H+ +T +
Sbjct: 96 HATALTVDGKVFWWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSS 155
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAE--FSMILDCNGNLHS 239
G +Y G + G+ G G+ T Q LKP +K G +++V CG+ ++ L G + S
Sbjct: 156 GELYTWGLGEYGRLGHGDNTTQ-LKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 214
Query: 240 FGMPEYGQLG 249
+G ++G+LG
Sbjct: 215 WGDGDFGKLG 224
Score = 54.8 bits (126), Expect = 6e-07
Identities = 32/136 (23%), Positives = 67/136 (49%), Gaps = 2/136 (1%)
Query: 115 IVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRH 174
+ G ++ +++EG +++G G+LG G + ++P+ + L G+ + G
Sbjct: 194 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 253
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDC 233
+L +T +G V+ G + G G+ + KP ++ G IV V GA + +
Sbjct: 254 FSLALTKSGVVWTWGKGDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTD 312
Query: 234 NGNLHSFGMPEYGQLG 249
+G ++++G ++GQ G
Sbjct: 313 SGQVYAWGDNDHGQQG 328
>AK096654-1|BAC04833.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39335 fis, clone OCBBF2017398, moderately
similar to Homo sapiens RCC1-like G exchanging factor
RLG mRNA. ).
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 78/284 (27%), Positives = 130/284 (45%), Gaps = 37/284 (13%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
++ V G +A ++ V++ E + FG N LG GD + VP+ + L GK I + G
Sbjct: 23 KVCVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYG 82
Query: 173 R-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GTPIVKVGCGAEFSM 229
H L T+ G VYA G N Q G G TT Q + P ++ N +V+V CG+ SM
Sbjct: 83 SGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSM 141
Query: 230 ILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQIT--LYIQKSKDGYIT 287
L +G + ++G GQ+G + + P+++T L+I++
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR------- 182
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+V ++CG ++A+ + WG+ G G+LG ++ P + +V
Sbjct: 183 ------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV--C 234
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVH 387
V + CG ++LA+ D+G L+ +G TG N P H
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Score = 81.4 bits (192), Expect = 6e-15
Identities = 72/271 (26%), Positives = 112/271 (41%), Gaps = 37/271 (13%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H +L +E+G Y +G N QLG G T P ++ L K ++ A G HH++ +
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT----PIVKVGCGAEFSMILDCNGNL 237
G V+A G N GQ G G+T Q PT K +V + CG SM + NG +
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQ---PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEV 202
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+ +G GQLG +G + H V + +
Sbjct: 203 YGWGYNGNGQLGLGNNGNQLTPVRVAALH------------------------SVCVNQI 238
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG HT+A+ ++WG +G+LG + + P I R V C +
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV--EKERVVEIAACHSAH 296
Query: 358 SLAVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
+ A QG ++M+GQ + G++ + P H
Sbjct: 297 TSAAKTQGGHVYMWGQCR--GQSVILPHLTH 325
Score = 64.9 bits (151), Expect = 6e-10
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
R++ C S+ V + GE Y +G N GQLG G+ + P V L + G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGC--GAEFSMI 230
HTL +TD G +YA G N GQ G GN +L P I +V++ A S
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKN-NLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 231 LDCNGNLHSFG 241
G+++ +G
Sbjct: 301 KTQGGHVYMWG 311
Score = 64.1 bits (149), Expect = 1e-09
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 33/262 (12%)
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC-NG 235
L+VTD V+ G N S G G+ ++ G I + G+ ++L +G
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
Query: 236 NLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIV 295
++++G Y QLG+ T + P Q+ + +K V V
Sbjct: 95 VVYAWGHNGYSQLGNGTTNQGIA------------PVQVCTNLL---------IKQV--V 131
Query: 296 DLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG 355
+++CG++H++A+ + F+WG+ G++G ++ PR + + R V + CG
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR-VVGIACGQ 190
Query: 356 TYSLAVNDQGALFMFGQ--TKRTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
T S+AV D G ++ +G + G N + P V L + + + D
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTD 250
Query: 410 DSLI-AWGVSPTYGELGMGEIN 430
+ L+ AWG + TYG+LG G N
Sbjct: 251 EGLLYAWGAN-TYGQLGTGNKN 271
Score = 56.4 bits (130), Expect = 2e-07
Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 12/181 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRA-FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ V + + ++WG G+ +LG+ P + + + + V V
Sbjct: 76 IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVA 134
Query: 353 CGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVHDLTGWNIKSV---GTSNTSIV 405
CG +S+A+ G +F +G +G P P +IK V TS +
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
D+ + WG + G+LG+G N + P V+ + S+ + Q+ GY+HTL L D
Sbjct: 195 AVLDNGEVYGWGYNGN-GQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 465 I 465
+
Sbjct: 253 L 253
>AJ319660-1|CAC40027.1| 531|Homo sapiens guanine nucleotide
exchange factor protein.
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 78/284 (27%), Positives = 130/284 (45%), Gaps = 37/284 (13%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
++ V G +A ++ V++ E + FG N LG GD + VP+ + L GK I + G
Sbjct: 23 KVCVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYG 82
Query: 173 R-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GTPIVKVGCGAEFSM 229
H L T+ G VYA G N Q G G TT Q + P ++ N +V+V CG+ SM
Sbjct: 83 SGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSM 141
Query: 230 ILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQIT--LYIQKSKDGYIT 287
L +G + ++G GQ+G + + P+++T L+I++
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR------- 182
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+V ++CG ++A+ + WG+ G G+LG ++ P + +V
Sbjct: 183 ------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV--C 234
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVH 387
V + CG ++LA+ D+G L+ +G TG N P H
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Score = 81.4 bits (192), Expect = 6e-15
Identities = 72/271 (26%), Positives = 112/271 (41%), Gaps = 37/271 (13%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H +L +E+G Y +G N QLG G T P ++ L K ++ A G HH++ +
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT----PIVKVGCGAEFSMILDCNGNL 237
G V+A G N GQ G G+T Q PT K +V + CG SM + NG +
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQ---PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEV 202
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+ +G GQLG +G + H V + +
Sbjct: 203 YGWGYNGNGQLGLGNNGNQLTPVRVAALH------------------------SVCVNQI 238
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG HT+A+ ++WG +G+LG + + P I R V C +
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV--EKERVVEIAACHSAH 296
Query: 358 SLAVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
+ A QG ++M+GQ + G++ + P H
Sbjct: 297 TSAAKTQGGHVYMWGQCR--GQSVILPHLTH 325
Score = 64.9 bits (151), Expect = 6e-10
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
R++ C S+ V + GE Y +G N GQLG G+ + P V L + G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGC--GAEFSMI 230
HTL +TD G +YA G N GQ G GN +L P I +V++ A S
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKN-NLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 231 LDCNGNLHSFG 241
G+++ +G
Sbjct: 301 KTQGGHVYMWG 311
Score = 64.1 bits (149), Expect = 1e-09
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 33/262 (12%)
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC-NG 235
L+VTD V+ G N S G G+ ++ G I + G+ ++L +G
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
Query: 236 NLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIV 295
++++G Y QLG+ T + P Q+ + +K V V
Sbjct: 95 VVYAWGHNGYSQLGNGTTNQGIA------------PVQVCTNLL---------IKQV--V 131
Query: 296 DLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG 355
+++CG++H++A+ + F+WG+ G++G ++ PR + + R V + CG
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR-VVGIACGQ 190
Query: 356 TYSLAVNDQGALFMFGQ--TKRTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
T S+AV D G ++ +G + G N + P V L + + + D
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTD 250
Query: 410 DSLI-AWGVSPTYGELGMGEIN 430
+ L+ AWG + TYG+LG G N
Sbjct: 251 EGLLYAWGAN-TYGQLGTGNKN 271
Score = 56.4 bits (130), Expect = 2e-07
Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 12/181 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRA-FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ V + + ++WG G+ +LG+ P + + + + V V
Sbjct: 76 IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVA 134
Query: 353 CGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVHDLTGWNIKSV---GTSNTSIV 405
CG +S+A+ G +F +G +G P P +IK V TS +
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
D+ + WG + G+LG+G N + P V+ + S+ + Q+ GY+HTL L D
Sbjct: 195 AVLDNGEVYGWGYNGN-GQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 465 I 465
+
Sbjct: 253 L 253
>AF334406-1|AAK38372.1| 531|Homo sapiens CLLL7 protein protein.
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 78/284 (27%), Positives = 130/284 (45%), Gaps = 37/284 (13%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
++ V G +A ++ V++ E + FG N LG GD + VP+ + L GK I + G
Sbjct: 23 KVCVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYG 82
Query: 173 R-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GTPIVKVGCGAEFSM 229
H L T+ G VYA G N Q G G TT Q + P ++ N +V+V CG+ SM
Sbjct: 83 SGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSM 141
Query: 230 ILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQIT--LYIQKSKDGYIT 287
L +G + ++G GQ+G + + P+++T L+I++
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR------- 182
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+V ++CG ++A+ + WG+ G G+LG ++ P + +V
Sbjct: 183 ------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV--C 234
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVH 387
V + CG ++LA+ D+G L+ +G TG N P H
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Score = 81.4 bits (192), Expect = 6e-15
Identities = 72/271 (26%), Positives = 112/271 (41%), Gaps = 37/271 (13%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H +L +E+G Y +G N QLG G T P ++ L K ++ A G HH++ +
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT----PIVKVGCGAEFSMILDCNGNL 237
G V+A G N GQ G G+T Q PT K +V + CG SM + NG +
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQ---PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEV 202
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+ +G GQLG +G + H V + +
Sbjct: 203 YGWGYNGNGQLGLGNNGNQLTPVRVAALH------------------------SVCVNQI 238
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG HT+A+ ++WG +G+LG + + P I R V C +
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV--EKERVVEIAACHSAH 296
Query: 358 SLAVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
+ A QG ++M+GQ + G++ + P H
Sbjct: 297 TSAAKTQGGHVYMWGQCR--GQSVILPHLTH 325
Score = 64.9 bits (151), Expect = 6e-10
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
R++ C S+ V + GE Y +G N GQLG G+ + P V L + G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGC--GAEFSMI 230
HTL +TD G +YA G N GQ G GN +L P I +V++ A S
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKN-NLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 231 LDCNGNLHSFG 241
G+++ +G
Sbjct: 301 KTQGGHVYMWG 311
Score = 64.1 bits (149), Expect = 1e-09
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 33/262 (12%)
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC-NG 235
L+VTD V+ G N S G G+ ++ G I + G+ ++L +G
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
Query: 236 NLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIV 295
++++G Y QLG+ T + P Q+ + +K V V
Sbjct: 95 VVYAWGHNGYSQLGNGTTNQGIA------------PVQVCTNLL---------IKQV--V 131
Query: 296 DLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG 355
+++CG++H++A+ + F+WG+ G++G ++ PR + + R V + CG
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR-VVGIACGQ 190
Query: 356 TYSLAVNDQGALFMFGQ--TKRTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
T S+AV D G ++ +G + G N + P V L + + + D
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTD 250
Query: 410 DSLI-AWGVSPTYGELGMGEIN 430
+ L+ AWG + TYG+LG G N
Sbjct: 251 EGLLYAWGAN-TYGQLGTGNKN 271
Score = 56.4 bits (130), Expect = 2e-07
Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 12/181 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRA-FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ V + + ++WG G+ +LG+ P + + + + V V
Sbjct: 76 IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVA 134
Query: 353 CGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVHDLTGWNIKSV---GTSNTSIV 405
CG +S+A+ G +F +G +G P P +IK V TS +
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
D+ + WG + G+LG+G N + P V+ + S+ + Q+ GY+HTL L D
Sbjct: 195 AVLDNGEVYGWGYNGN-GQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 465 I 465
+
Sbjct: 253 L 253
>AL139321-5|CAH71047.1| 531|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 531
Score = 98.3 bits (234), Expect = 5e-20
Identities = 78/281 (27%), Positives = 128/281 (45%), Gaps = 37/281 (13%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR-H 174
V G +A ++ V++ E + FG N LG GD + VP+ + L GK I + G
Sbjct: 26 VFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGP 85
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GTPIVKVGCGAEFSMILD 232
H L T+ G VYA G N Q G G TT Q + P ++ N +V+V CG+ SM L
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALA 144
Query: 233 CNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQIT--LYIQKSKDGYITPVK 290
+G + ++G GQ+G + + P+++T L+I++
Sbjct: 145 ADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR---------- 182
Query: 291 DVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
+V ++CG ++A+ + WG+ G G+LG ++ P + +V V
Sbjct: 183 ---VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV--CVNQ 237
Query: 351 VHCGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVH 387
+ CG ++LA+ D+G L+ +G TG N P H
Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Score = 85.0 bits (201), Expect = 5e-16
Identities = 47/139 (33%), Positives = 75/139 (53%), Gaps = 3/139 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE-LKGKNIIHAAV 171
+++ C + HS+ ++ +GE + +G N CGQ+G G T + P V L K ++ A
Sbjct: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMI 230
G+ ++ V D G VY G N +GQ GLGN Q L P R+ + + ++ CG ++
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQ-LTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 231 LDCNGNLHSFGMPEYGQLG 249
L G L+++G YGQLG
Sbjct: 248 LTDEGLLYAWGANTYGQLG 266
Score = 81.4 bits (192), Expect = 6e-15
Identities = 72/271 (26%), Positives = 112/271 (41%), Gaps = 37/271 (13%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H +L +E+G Y +G N QLG G T P ++ L K ++ A G HH++ +
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT----PIVKVGCGAEFSMILDCNGNL 237
G V+A G N GQ G G+T Q PT K +V + CG SM + NG +
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQ---PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEV 202
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+ +G GQLG +G + H V + +
Sbjct: 203 YGWGYNGNGQLGLGNNGNQLTPVRVAALH------------------------SVCVNQI 238
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG HT+A+ ++WG +G+LG + + P I R V C +
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV--EKERVVEIAACHSAH 296
Query: 358 SLAVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
+ A QG ++M+GQ + G++ + P H
Sbjct: 297 TSAAKTQGGHVYMWGQCR--GQSVILPHLTH 325
Score = 64.9 bits (151), Expect = 6e-10
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
R++ C S+ V + GE Y +G N GQLG G+ + P V L + G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGC--GAEFSMI 230
HTL +TD G +YA G N GQ G GN +L P I +V++ A S
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKN-NLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 231 LDCNGNLHSFG 241
G+++ +G
Sbjct: 301 KTQGGHVYMWG 311
Score = 64.1 bits (149), Expect = 1e-09
Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 33/262 (12%)
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC-NG 235
L+VTD V+ G N S G G+ ++ G I + G+ ++L +G
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
Query: 236 NLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIV 295
++++G Y QLG+ T + P Q+ + +K V V
Sbjct: 95 VVYAWGHNGYSQLGNGTTNQGIA------------PVQVCTNLL---------IKQV--V 131
Query: 296 DLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG 355
+++CG++H++A+ + F+WG+ G++G ++ PR + + R V + CG
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR-VVGIACGQ 190
Query: 356 TYSLAVNDQGALFMFGQ--TKRTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
T S+AV D G ++ +G + G N + P V L + + + D
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTD 250
Query: 410 DSLI-AWGVSPTYGELGMGEIN 430
+ L+ AWG + TYG+LG G N
Sbjct: 251 EGLLYAWGAN-TYGQLGTGNKN 271
Score = 56.4 bits (130), Expect = 2e-07
Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 12/181 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRA-FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ V + + ++WG G+ +LG+ P + + + + V V
Sbjct: 76 IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVA 134
Query: 353 CGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVHDLTGWNIKSV---GTSNTSIV 405
CG +S+A+ G +F +G +G P P +IK V TS +
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
D+ + WG + G+LG+G N + P V+ + S+ + Q+ GY+HTL L D
Sbjct: 195 AVLDNGEVYGWGYNGN-GQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 465 I 465
+
Sbjct: 253 L 253
>BC042047-1|AAH42047.2| 1022|Homo sapiens hect domain and RLD 6
protein.
Length = 1022
Score = 97.5 bits (232), Expect = 9e-20
Identities = 71/256 (27%), Positives = 121/256 (47%), Gaps = 27/256 (10%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPELKGKNIIHAAVGRHHTL 177
C HS+ V +G + +G + GQLG G+ S P+ + L II + G +H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGN 236
++ V++ G N GQ GLG P P R++ G P+ +V G S L G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
SFG G N+ G +L+ +P +Q +K + +K++ +V
Sbjct: 202 --SFGW------GSNSAG-------QLALSGRNVP------VQSNKPLSVGALKNLGVVY 240
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGT 356
+SCG+ HT + + F++G G+LG++ ++ P+L++ D + V + CG
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL---VSQIDCGSY 297
Query: 357 YSLA-VNDQGALFMFG 371
++LA V+ G + FG
Sbjct: 298 HTLAYVHTTGQVVSFG 313
Score = 79.0 bits (186), Expect = 3e-14
Identities = 69/267 (25%), Positives = 110/267 (41%), Gaps = 30/267 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L+ + G N+ GQLG +PE + L+ + + G+ H+L V
Sbjct: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHK 93
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFG 241
G V+A G GQ G+G P +I N I++V CG S+ L + + S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+GQLG GK F P Q + +S +G + + ++ G
Sbjct: 154 KNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQVAAGG 190
Query: 302 NHTVAIDSMKRAFSWGFGGFGRL---GHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
H+ A+ +F WG G+L G N P + + GV + CG ++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL--GVVYISCGDAHT 248
Query: 359 LAVNDQGALFMFGQTKRTGEANMYPKP 385
+ G +F FG R+G+ P P
Sbjct: 249 AVLTQDGKVFTFGD-NRSGQLGYSPTP 274
Score = 78.6 bits (185), Expect = 5e-14
Identities = 85/307 (27%), Positives = 140/307 (45%), Gaps = 39/307 (12%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-V 221
G ++ AA G H+L + V +CGDN GQ G L P I+ T IV V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVDLV 80
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG E S+ + G + ++G GQLG G++ ++SF PK+I
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGI---GEF----KEISF----TPKKIMT----- 124
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKY 340
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++
Sbjct: 125 -------LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS 177
Query: 341 FDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIK 395
+ G + V GG +S A++ G F +G + G+ + + PV L+ +K
Sbjct: 178 LE--GIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 396 SVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVA 451
++G S A L G T+G+ G++ S P+ V R+D L ++Q+
Sbjct: 235 NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQID 293
Query: 452 MGYSHTL 458
G HTL
Sbjct: 294 CGSYHTL 300
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 129 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLGYS 271
Score = 65.7 bits (153), Expect = 3e-10
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%)
Query: 291 DVTIVDL-SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN-VPRLIKYFDTVGRGV 348
+ IVDL SCG H++A+ R F+WG G G+LG E K+ + P+ I + + +
Sbjct: 73 ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK--I 130
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSN 401
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 190
Query: 402 T-SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTL 458
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT
Sbjct: 191 AHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTA 249
Query: 459 LL 460
+L
Sbjct: 250 VL 251
Score = 64.1 bits (149), Expect = 1e-09
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 11/175 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ + G H++ + + R S G G+LG + +P I+ +T+ V V C
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI--VDLVSC 82
Query: 354 GGTYSLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIV 405
G +SLAV +G +F +G + G E + PK + L I V + S+
Sbjct: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 143 LSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G + G
Sbjct: 238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS 296
Query: 174 HHTL-FVTDTGCVYACGDNKS 193
+HTL +V TG V + G S
Sbjct: 297 YHTLAYVHTTGQVVSFGHGPS 317
>AY653202-1|AAV66896.1| 364|Homo sapiens truncated HERC6 protein.
Length = 364
Score = 97.5 bits (232), Expect = 9e-20
Identities = 71/256 (27%), Positives = 121/256 (47%), Gaps = 27/256 (10%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPELKGKNIIHAAVGRHHTL 177
C HS+ V +G + +G + GQLG G+ S P+ + L II + G +H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGN 236
++ V++ G N GQ GLG P P R++ G P+ +V G S L G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
SFG G N+ G +L+ +P +Q +K + +K++ +V
Sbjct: 202 --SFGW------GSNSAG-------QLALSGRNVP------VQSNKPLSVGALKNLGVVY 240
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGT 356
+SCG+ HT + + F++G G+LG++ ++ P+L++ D + V + CG
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL---VSQIDCGSY 297
Query: 357 YSLA-VNDQGALFMFG 371
++LA V+ G + FG
Sbjct: 298 HTLAYVHTTGQVVSFG 313
Score = 79.0 bits (186), Expect = 3e-14
Identities = 69/267 (25%), Positives = 110/267 (41%), Gaps = 30/267 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L+ + G N+ GQLG +PE + L+ + + G+ H+L V
Sbjct: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHK 93
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFG 241
G V+A G GQ G+G P +I N I++V CG S+ L + + S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+GQLG GK F P Q + +S +G + + ++ G
Sbjct: 154 KNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQVAAGG 190
Query: 302 NHTVAIDSMKRAFSWGFGGFGRL---GHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
H+ A+ +F WG G+L G N P + + GV + CG ++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL--GVVYISCGDAHT 248
Query: 359 LAVNDQGALFMFGQTKRTGEANMYPKP 385
+ G +F FG R+G+ P P
Sbjct: 249 AVLTQDGKVFTFGD-NRSGQLGYSPTP 274
Score = 78.6 bits (185), Expect = 5e-14
Identities = 85/307 (27%), Positives = 140/307 (45%), Gaps = 39/307 (12%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-V 221
G ++ AA G H+L + V +CGDN GQ G L P I+ T IV V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVDLV 80
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG E S+ + G + ++G GQLG G++ ++SF PK+I
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGI---GEF----KEISF----TPKKIMT----- 124
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKY 340
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++
Sbjct: 125 -------LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS 177
Query: 341 FDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIK 395
+ G + V GG +S A++ G F +G + G+ + + PV L+ +K
Sbjct: 178 LE--GIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 396 SVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVA 451
++G S A L G T+G+ G++ S P+ V R+D L ++Q+
Sbjct: 235 NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQID 293
Query: 452 MGYSHTL 458
G HTL
Sbjct: 294 CGSYHTL 300
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 129 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLGYS 271
Score = 65.7 bits (153), Expect = 3e-10
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%)
Query: 291 DVTIVDL-SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN-VPRLIKYFDTVGRGV 348
+ IVDL SCG H++A+ R F+WG G G+LG E K+ + P+ I + + +
Sbjct: 73 ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK--I 130
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSN 401
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 190
Query: 402 T-SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTL 458
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT
Sbjct: 191 AHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTA 249
Query: 459 LL 460
+L
Sbjct: 250 VL 251
Score = 64.1 bits (149), Expect = 1e-09
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 11/175 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ + G H++ + + R S G G+LG + +P I+ +T+ V V C
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI--VDLVSC 82
Query: 354 GGTYSLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIV 405
G +SLAV +G +F +G + G E + PK + L I V + S+
Sbjct: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 143 LSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G + G
Sbjct: 238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS 296
Query: 174 HHTL-FVTDTGCVYACGDNKS 193
+HTL +V TG V + G S
Sbjct: 297 YHTLAYVHTTGQVVSFGHGPS 317
>AY653201-1|AAV66895.1| 986|Homo sapiens HERC6 splice variant
protein.
Length = 986
Score = 97.5 bits (232), Expect = 9e-20
Identities = 71/256 (27%), Positives = 121/256 (47%), Gaps = 27/256 (10%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPELKGKNIIHAAVGRHHTL 177
C HS+ V +G + +G + GQLG G+ S P+ + L II + G +H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGN 236
++ V++ G N GQ GLG P P R++ G P+ +V G S L G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
SFG G N+ G +L+ +P +Q +K + +K++ +V
Sbjct: 202 --SFGW------GSNSAG-------QLALSGRNVP------VQSNKPLSVGALKNLGVVY 240
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGT 356
+SCG+ HT + + F++G G+LG++ ++ P+L++ D + V + CG
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL---VSQIDCGSY 297
Query: 357 YSLA-VNDQGALFMFG 371
++LA V+ G + FG
Sbjct: 298 HTLAYVHTTGQVVSFG 313
Score = 79.0 bits (186), Expect = 3e-14
Identities = 69/267 (25%), Positives = 110/267 (41%), Gaps = 30/267 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L+ + G N+ GQLG +PE + L+ + + G+ H+L V
Sbjct: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHK 93
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFG 241
G V+A G GQ G+G P +I N I++V CG S+ L + + S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+GQLG GK F P Q + +S +G + + ++ G
Sbjct: 154 KNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQVAAGG 190
Query: 302 NHTVAIDSMKRAFSWGFGGFGRL---GHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
H+ A+ +F WG G+L G N P + + GV + CG ++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL--GVVYISCGDAHT 248
Query: 359 LAVNDQGALFMFGQTKRTGEANMYPKP 385
+ G +F FG R+G+ P P
Sbjct: 249 AVLTQDGKVFTFGD-NRSGQLGYSPTP 274
Score = 78.6 bits (185), Expect = 5e-14
Identities = 85/307 (27%), Positives = 140/307 (45%), Gaps = 39/307 (12%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-V 221
G ++ AA G H+L + V +CGDN GQ G L P I+ T IV V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVDLV 80
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG E S+ + G + ++G GQLG G++ ++SF PK+I
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGI---GEF----KEISF----TPKKIMT----- 124
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKY 340
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++
Sbjct: 125 -------LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS 177
Query: 341 FDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIK 395
+ G + V GG +S A++ G F +G + G+ + + PV L+ +K
Sbjct: 178 LE--GIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 396 SVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVA 451
++G S A L G T+G+ G++ S P+ V R+D L ++Q+
Sbjct: 235 NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQID 293
Query: 452 MGYSHTL 458
G HTL
Sbjct: 294 CGSYHTL 300
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 129 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLGYS 271
Score = 65.7 bits (153), Expect = 3e-10
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%)
Query: 291 DVTIVDL-SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN-VPRLIKYFDTVGRGV 348
+ IVDL SCG H++A+ R F+WG G G+LG E K+ + P+ I + + +
Sbjct: 73 ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK--I 130
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSN 401
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 190
Query: 402 T-SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTL 458
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT
Sbjct: 191 AHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTA 249
Query: 459 LL 460
+L
Sbjct: 250 VL 251
Score = 64.1 bits (149), Expect = 1e-09
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 11/175 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ + G H++ + + R S G G+LG + +P I+ +T+ V V C
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI--VDLVSC 82
Query: 354 GGTYSLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIV 405
G +SLAV +G +F +G + G E + PK + L I V + S+
Sbjct: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 143 LSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G + G
Sbjct: 238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS 296
Query: 174 HHTL-FVTDTGCVYACGDNKS 193
+HTL +V TG V + G S
Sbjct: 297 YHTLAYVHTTGQVVSFGHGPS 317
>AF336798-1|AAQ14893.1| 1022|Homo sapiens HERC6 protein.
Length = 1022
Score = 97.5 bits (232), Expect = 9e-20
Identities = 71/256 (27%), Positives = 121/256 (47%), Gaps = 27/256 (10%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPELKGKNIIHAAVGRHHTL 177
C HS+ V +G + +G + GQLG G+ S P+ + L II + G +H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGN 236
++ V++ G N GQ GLG P P R++ G P+ +V G S L G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
SFG G N+ G +L+ +P +Q +K + +K++ +V
Sbjct: 202 --SFGW------GSNSAG-------QLALSGRNVP------VQSNKPLSVGALKNLGVVY 240
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGT 356
+SCG+ HT + + F++G G+LG++ ++ P+L++ D + V + CG
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL---VSQIDCGSY 297
Query: 357 YSLA-VNDQGALFMFG 371
++LA V+ G + FG
Sbjct: 298 HTLAYVHTTGQVVSFG 313
Score = 79.0 bits (186), Expect = 3e-14
Identities = 69/267 (25%), Positives = 110/267 (41%), Gaps = 30/267 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L+ + G N+ GQLG +PE + L+ + + G+ H+L V
Sbjct: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHK 93
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFG 241
G V+A G GQ G+G P +I N I++V CG S+ L + + S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+GQLG GK F P Q + +S +G + + ++ G
Sbjct: 154 KNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQVAAGG 190
Query: 302 NHTVAIDSMKRAFSWGFGGFGRL---GHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
H+ A+ +F WG G+L G N P + + GV + CG ++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL--GVVYISCGDAHT 248
Query: 359 LAVNDQGALFMFGQTKRTGEANMYPKP 385
+ G +F FG R+G+ P P
Sbjct: 249 AVLTQDGKVFTFGD-NRSGQLGYSPTP 274
Score = 78.6 bits (185), Expect = 5e-14
Identities = 85/307 (27%), Positives = 140/307 (45%), Gaps = 39/307 (12%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-V 221
G ++ AA G H+L + V +CGDN GQ G L P I+ T IV V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVDLV 80
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG E S+ + G + ++G GQLG G++ ++SF PK+I
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGI---GEF----KEISF----TPKKIMT----- 124
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKY 340
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++
Sbjct: 125 -------LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS 177
Query: 341 FDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIK 395
+ G + V GG +S A++ G F +G + G+ + + PV L+ +K
Sbjct: 178 LE--GIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 396 SVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVA 451
++G S A L G T+G+ G++ S P+ V R+D L ++Q+
Sbjct: 235 NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQID 293
Query: 452 MGYSHTL 458
G HTL
Sbjct: 294 CGSYHTL 300
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 129 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLGYS 271
Score = 65.7 bits (153), Expect = 3e-10
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%)
Query: 291 DVTIVDL-SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN-VPRLIKYFDTVGRGV 348
+ IVDL SCG H++A+ R F+WG G G+LG E K+ + P+ I + + +
Sbjct: 73 ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK--I 130
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSN 401
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 190
Query: 402 T-SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTL 458
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT
Sbjct: 191 AHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTA 249
Query: 459 LL 460
+L
Sbjct: 250 VL 251
Score = 64.1 bits (149), Expect = 1e-09
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 11/175 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ + G H++ + + R S G G+LG + +P I+ +T+ V V C
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI--VDLVSC 82
Query: 354 GGTYSLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIV 405
G +SLAV +G +F +G + G E + PK + L I V + S+
Sbjct: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 143 LSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G + G
Sbjct: 238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS 296
Query: 174 HHTL-FVTDTGCVYACGDNKS 193
+HTL +V TG V + G S
Sbjct: 297 YHTLAYVHTTGQVVSFGHGPS 317
>BC029052-1|AAH29052.1| 551|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 551
Score = 97.1 bits (231), Expect = 1e-19
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H VL + EGE +T+G NA QLG G T VP + L K +I A G +H+L +T
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIK--YNGTPIVKVGCGAEFSMILDCNGNLHS 239
G V+A G N SGQ G G+T Q + P R+ +V + CG M + G ++
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPI-PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
Query: 240 FGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSC 299
+G GQLG G + P + + ++ + + ++C
Sbjct: 229 WGYNGNGQLGLGNSGN------------QPTPCR------------VAALQGIRVQRVAC 264
Query: 300 GNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
G HT+ + + ++WG +G+LG + +++ P + R + C T++
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV--EKDRIIEIAACHSTHTS 322
Query: 360 AVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
A QG ++M+GQ + G++ + P H
Sbjct: 323 AAKTQGGHVYMWGQCR--GQSVILPHLTH 349
Score = 91.9 bits (218), Expect = 5e-18
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 39/296 (13%)
Query: 104 FHKFTDRRYRLIVSGC---TAGHSVLVSE-EGEAYTFGRNACGQLGFGDTVTRSVPELVP 159
F ++ +LI C +AG+ VL + E + G N CG LG GD + P +
Sbjct: 34 FSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLD 93
Query: 160 ELKGKNIIHAAVGR-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GT 216
L GK I + G H + T G V+ G N Q G G TT L P I N
Sbjct: 94 SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNG-TTNHGLVPCHISTNLSNK 152
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
+++V CG+ S++L +G + ++G GQ+G + + IP+++T
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTG 200
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+Q +V ++CG +A+ + WG+ G G+LG ++ P
Sbjct: 201 CLQNK-----------VVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 249
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPV 386
+ G V+ V CG ++L + D+G ++ +G + G N YP PV
Sbjct: 250 RVAALQ--GIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
Score = 90.2 bits (214), Expect = 1e-17
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ L H T+ + ++ C + HS++++ +GE + +G N GQ+G G TV + +P
Sbjct: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L+ K ++ A G+ + V DTG VY G N +GQ GLGN+ Q P R+
Sbjct: 196 RRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ-PTPCRVAAL 254
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G + +V CG +++L G ++++G YGQLG
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Score = 69.3 bits (162), Expect = 3e-11
Identities = 67/278 (24%), Positives = 125/278 (44%), Gaps = 36/278 (12%)
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMIL- 231
+ L+ T ++ G N G GLG+ I +P R+ NG I + G+ ++L
Sbjct: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-EPRRLDSLNGKKIACLSYGSGPHIVLA 114
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + ++G Y QLG+ T T+ L +P I+ T + +
Sbjct: 115 TTEGEVFTWGHNAYSQLGNGT------TNHGL------VPCHIS-----------TNLSN 151
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+++++CG+ H++ + S F+WG+ G++G ++ +PR + + V ++
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTI 210
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSVGTSNTSIV 405
CG +AV D G ++++G G + P P V L G ++ V +
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
Query: 406 IAADDSLI-AWGVSPTYGELGMG-EINKSTAKPKEVSR 441
+ D+ + AWG + +YG+LG G + N+S P V +
Sbjct: 271 VLTDEGQVYAWGAN-SYGQLGTGNKSNQSYPTPVTVEK 307
Score = 66.9 bits (156), Expect = 1e-10
Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C + V + GE Y +G N GQLG G++ + P V L+G + A G
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV 221
HTL +TD G VYA G N GQ G GN + Q PT + I+++
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY-PTPVTVEKDRIIEI 313
Score = 55.2 bits (127), Expect = 5e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 12/178 (6%)
Query: 294 IVDLSCGNN-HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ H V + F+WG + +LG+ VP I + + V V
Sbjct: 100 IACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVA 158
Query: 353 CGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-HDLTGWN----IKSVGTSNTSIV 405
CG +SL + G +F +G + G + +P+ +TG + ++ +
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCD 462
D + WG + G+LG+G P V+ + + + +VA GY+HTL+L D
Sbjct: 219 AVVDTGEVYVWGYNGN-GQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVLTD 274
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H++++++EG+ Y +G N+ GQLG G+ +S P V K + I AA HT
Sbjct: 264 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Query: 179 V-TDTGCVYACG 189
T G VY G
Sbjct: 324 AKTQGGHVYMWG 335
>AY341245-1|AAP88928.1| 551|Homo sapiens chromosome condensation
1-like protein.
Length = 551
Score = 97.1 bits (231), Expect = 1e-19
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H VL + EGE +T+G NA QLG G T VP + L K +I A G +H+L +T
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIK--YNGTPIVKVGCGAEFSMILDCNGNLHS 239
G V+A G N SGQ G G+T Q + P R+ +V + CG M + G ++
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPI-PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
Query: 240 FGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSC 299
+G GQLG G + P + + ++ + + ++C
Sbjct: 229 WGYNGNGQLGLGNSGN------------QPTPCR------------VAALQGIRVQRVAC 264
Query: 300 GNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
G HT+ + + ++WG +G+LG + +++ P + R + C T++
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV--EKDRIIEIAACHSTHTS 322
Query: 360 AVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
A QG ++M+GQ + G++ + P H
Sbjct: 323 AAKTQGGHVYMWGQCR--GQSVILPHLTH 349
Score = 91.9 bits (218), Expect = 5e-18
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 39/296 (13%)
Query: 104 FHKFTDRRYRLIVSGC---TAGHSVLVSE-EGEAYTFGRNACGQLGFGDTVTRSVPELVP 159
F ++ +LI C +AG+ VL + E + G N CG LG GD + P +
Sbjct: 34 FSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLD 93
Query: 160 ELKGKNIIHAAVGR-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GT 216
L GK I + G H + T G V+ G N Q G G TT L P I N
Sbjct: 94 SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNG-TTNHGLVPCHISTNLSNK 152
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
+++V CG+ S++L +G + ++G GQ+G + + IP+++T
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTG 200
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+Q +V ++CG +A+ + WG+ G G+LG ++ P
Sbjct: 201 CLQNK-----------VVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 249
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPV 386
+ G V+ V CG ++L + D+G ++ +G + G N YP PV
Sbjct: 250 RVAALQ--GIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
Score = 90.2 bits (214), Expect = 1e-17
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ L H T+ + ++ C + HS++++ +GE + +G N GQ+G G TV + +P
Sbjct: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L+ K ++ A G+ + V DTG VY G N +GQ GLGN+ Q P R+
Sbjct: 196 RRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ-PTPCRVAAL 254
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G + +V CG +++L G ++++G YGQLG
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Score = 69.3 bits (162), Expect = 3e-11
Identities = 67/278 (24%), Positives = 125/278 (44%), Gaps = 36/278 (12%)
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMIL- 231
+ L+ T ++ G N G GLG+ I +P R+ NG I + G+ ++L
Sbjct: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-EPRRLDSLNGKKIACLSYGSGPHIVLA 114
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + ++G Y QLG+ T T+ L +P I+ T + +
Sbjct: 115 TTEGEVFTWGHNAYSQLGNGT------TNHGL------VPCHIS-----------TNLSN 151
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+++++CG+ H++ + S F+WG+ G++G ++ +PR + + V ++
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTI 210
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSVGTSNTSIV 405
CG +AV D G ++++G G + P P V L G ++ V +
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
Query: 406 IAADDSLI-AWGVSPTYGELGMG-EINKSTAKPKEVSR 441
+ D+ + AWG + +YG+LG G + N+S P V +
Sbjct: 271 VLTDEGQVYAWGAN-SYGQLGTGNKSNQSYPTPVTVEK 307
Score = 66.9 bits (156), Expect = 1e-10
Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C + V + GE Y +G N GQLG G++ + P V L+G + A G
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV 221
HTL +TD G VYA G N GQ G GN + Q PT + I+++
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY-PTPVTVEKDRIIEI 313
Score = 55.2 bits (127), Expect = 5e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 12/178 (6%)
Query: 294 IVDLSCGNN-HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ H V + F+WG + +LG+ VP I + + V V
Sbjct: 100 IACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVA 158
Query: 353 CGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-HDLTGWN----IKSVGTSNTSIV 405
CG +SL + G +F +G + G + +P+ +TG + ++ +
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCD 462
D + WG + G+LG+G P V+ + + + +VA GY+HTL+L D
Sbjct: 219 AVVDTGEVYVWGYNGN-GQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVLTD 274
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H++++++EG+ Y +G N+ GQLG G+ +S P V K + I AA HT
Sbjct: 264 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Query: 179 V-TDTGCVYACG 189
T G VY G
Sbjct: 324 AKTQGGHVYMWG 335
>AL157813-1|CAH70795.1| 551|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 551
Score = 97.1 bits (231), Expect = 1e-19
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H VL + EGE +T+G NA QLG G T VP + L K +I A G +H+L +T
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIK--YNGTPIVKVGCGAEFSMILDCNGNLHS 239
G V+A G N SGQ G G+T Q + P R+ +V + CG M + G ++
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPI-PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
Query: 240 FGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSC 299
+G GQLG G + P + + ++ + + ++C
Sbjct: 229 WGYNGNGQLGLGNSGN------------QPTPCR------------VAALQGIRVQRVAC 264
Query: 300 GNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
G HT+ + + ++WG +G+LG + +++ P + R + C T++
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV--EKDRIIEIAACHSTHTS 322
Query: 360 AVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
A QG ++M+GQ + G++ + P H
Sbjct: 323 AAKTQGGHVYMWGQCR--GQSVILPHLTH 349
Score = 91.9 bits (218), Expect = 5e-18
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 39/296 (13%)
Query: 104 FHKFTDRRYRLIVSGC---TAGHSVLVSE-EGEAYTFGRNACGQLGFGDTVTRSVPELVP 159
F ++ +LI C +AG+ VL + E + G N CG LG GD + P +
Sbjct: 34 FSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLD 93
Query: 160 ELKGKNIIHAAVGR-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GT 216
L GK I + G H + T G V+ G N Q G G TT L P I N
Sbjct: 94 SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNG-TTNHGLVPCHISTNLSNK 152
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
+++V CG+ S++L +G + ++G GQ+G + + IP+++T
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTG 200
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+Q +V ++CG +A+ + WG+ G G+LG ++ P
Sbjct: 201 CLQNK-----------VVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 249
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPV 386
+ G V+ V CG ++L + D+G ++ +G + G N YP PV
Sbjct: 250 RVAALQ--GIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
Score = 90.2 bits (214), Expect = 1e-17
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ L H T+ + ++ C + HS++++ +GE + +G N GQ+G G TV + +P
Sbjct: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L+ K ++ A G+ + V DTG VY G N +GQ GLGN+ Q P R+
Sbjct: 196 RRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ-PTPCRVAAL 254
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G + +V CG +++L G ++++G YGQLG
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Score = 69.3 bits (162), Expect = 3e-11
Identities = 67/278 (24%), Positives = 125/278 (44%), Gaps = 36/278 (12%)
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMIL- 231
+ L+ T ++ G N G GLG+ I +P R+ NG I + G+ ++L
Sbjct: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-EPRRLDSLNGKKIACLSYGSGPHIVLA 114
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + ++G Y QLG+ T T+ L +P I+ T + +
Sbjct: 115 TTEGEVFTWGHNAYSQLGNGT------TNHGL------VPCHIS-----------TNLSN 151
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+++++CG+ H++ + S F+WG+ G++G ++ +PR + + V ++
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTI 210
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSVGTSNTSIV 405
CG +AV D G ++++G G + P P V L G ++ V +
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
Query: 406 IAADDSLI-AWGVSPTYGELGMG-EINKSTAKPKEVSR 441
+ D+ + AWG + +YG+LG G + N+S P V +
Sbjct: 271 VLTDEGQVYAWGAN-SYGQLGTGNKSNQSYPTPVTVEK 307
Score = 66.9 bits (156), Expect = 1e-10
Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C + V + GE Y +G N GQLG G++ + P V L+G + A G
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV 221
HTL +TD G VYA G N GQ G GN + Q PT + I+++
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY-PTPVTVEKDRIIEI 313
Score = 55.2 bits (127), Expect = 5e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 12/178 (6%)
Query: 294 IVDLSCGNN-HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ H V + F+WG + +LG+ VP I + + V V
Sbjct: 100 IACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVA 158
Query: 353 CGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-HDLTGWN----IKSVGTSNTSIV 405
CG +SL + G +F +G + G + +P+ +TG + ++ +
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCD 462
D + WG + G+LG+G P V+ + + + +VA GY+HTL+L D
Sbjct: 219 AVVDTGEVYVWGYNGN-GQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVLTD 274
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H++++++EG+ Y +G N+ GQLG G+ +S P V K + I AA HT
Sbjct: 264 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Query: 179 V-TDTGCVYACG 189
T G VY G
Sbjct: 324 AKTQGGHVYMWG 335
>AF060219-1|AAC79987.1| 551|Homo sapiens RCC1-like G exchanging
factor RLG protein.
Length = 551
Score = 97.1 bits (231), Expect = 1e-19
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H VL + EGE +T+G NA QLG G T VP + L K +I A G +H+L +T
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIK--YNGTPIVKVGCGAEFSMILDCNGNLHS 239
G V+A G N SGQ G G+T Q + P R+ +V + CG M + G ++
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPI-PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
Query: 240 FGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSC 299
+G GQLG G + P + + ++ + + ++C
Sbjct: 229 WGYNGNGQLGLGNSGN------------QPTPCR------------VAALQGIRVQRVAC 264
Query: 300 GNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
G HT+ + + ++WG +G+LG + +++ P + R + C T++
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV--EKDRIIEIAACHSTHTS 322
Query: 360 AVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
A QG ++M+GQ + G++ + P H
Sbjct: 323 AAKTQGGHVYMWGQCR--GQSVILPHLTH 349
Score = 91.9 bits (218), Expect = 5e-18
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 39/296 (13%)
Query: 104 FHKFTDRRYRLIVSGC---TAGHSVLVSE-EGEAYTFGRNACGQLGFGDTVTRSVPELVP 159
F ++ +LI C +AG+ VL + E + G N CG LG GD + P +
Sbjct: 34 FSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLD 93
Query: 160 ELKGKNIIHAAVGR-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GT 216
L GK I + G H + T G V+ G N Q G G TT L P I N
Sbjct: 94 SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNG-TTNHGLVPCHISTNLSNK 152
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
+++V CG+ S++L +G + ++G GQ+G + + IP+++T
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTG 200
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+Q +V ++CG +A+ + WG+ G G+LG ++ P
Sbjct: 201 CLQNK-----------VVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 249
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPV 386
+ G V+ V CG ++L + D+G ++ +G + G N YP PV
Sbjct: 250 RVAALQ--GIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 303
Score = 90.2 bits (214), Expect = 1e-17
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ L H T+ + ++ C + HS++++ +GE + +G N GQ+G G TV + +P
Sbjct: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 195
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L+ K ++ A G+ + V DTG VY G N +GQ GLGN+ Q P R+
Sbjct: 196 RRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ-PTPCRVAAL 254
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G + +V CG +++L G ++++G YGQLG
Sbjct: 255 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Score = 69.3 bits (162), Expect = 3e-11
Identities = 67/278 (24%), Positives = 125/278 (44%), Gaps = 36/278 (12%)
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMIL- 231
+ L+ T ++ G N G GLG+ I +P R+ NG I + G+ ++L
Sbjct: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-EPRRLDSLNGKKIACLSYGSGPHIVLA 114
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + ++G Y QLG+ T T+ L +P I+ T + +
Sbjct: 115 TTEGEVFTWGHNAYSQLGNGT------TNHGL------VPCHIS-----------TNLSN 151
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+++++CG+ H++ + S F+WG+ G++G ++ +PR + + V ++
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTI 210
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSVGTSNTSIV 405
CG +AV D G ++++G G + P P V L G ++ V +
Sbjct: 211 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
Query: 406 IAADDSLI-AWGVSPTYGELGMG-EINKSTAKPKEVSR 441
+ D+ + AWG + +YG+LG G + N+S P V +
Sbjct: 271 VLTDEGQVYAWGAN-SYGQLGTGNKSNQSYPTPVTVEK 307
Score = 66.9 bits (156), Expect = 1e-10
Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C + V + GE Y +G N GQLG G++ + P V L+G + A G
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 266
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV 221
HTL +TD G VYA G N GQ G GN + Q PT + I+++
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY-PTPVTVEKDRIIEI 313
Score = 55.2 bits (127), Expect = 5e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 12/178 (6%)
Query: 294 IVDLSCGNN-HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ H V + F+WG + +LG+ VP I + + V V
Sbjct: 100 IACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVA 158
Query: 353 CGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-HDLTGWN----IKSVGTSNTSIV 405
CG +SL + G +F +G + G + +P+ +TG + ++ +
Sbjct: 159 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCD 462
D + WG + G+LG+G P V+ + + + +VA GY+HTL+L D
Sbjct: 219 AVVDTGEVYVWGYNGN-GQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVLTD 274
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H++++++EG+ Y +G N+ GQLG G+ +S P V K + I AA HT
Sbjct: 264 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Query: 179 V-TDTGCVYACG 189
T G VY G
Sbjct: 324 AKTQGGHVYMWG 335
>AB209543-1|BAD92780.1| 556|Homo sapiens RCC1-like G exchanging
factor RLG variant protein.
Length = 556
Score = 97.1 bits (231), Expect = 1e-19
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP-ELVPELKGKNIIHAAVGRHHTLFVTD 181
H VL + EGE +T+G NA QLG G T VP + L K +I A G +H+L +T
Sbjct: 115 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 174
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIK--YNGTPIVKVGCGAEFSMILDCNGNLHS 239
G V+A G N SGQ G G+T Q + P R+ +V + CG M + G ++
Sbjct: 175 DGEVFAWGYNNSGQVGSGSTVNQPI-PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 233
Query: 240 FGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSC 299
+G GQLG G + P + + ++ + + ++C
Sbjct: 234 WGYNGNGQLGLGNSGN------------QPTPCR------------VAALQGIRVQRVAC 269
Query: 300 GNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSL 359
G HT+ + + ++WG +G+LG + +++ P + R + C T++
Sbjct: 270 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV--EKDRIIEIAACHSTHTS 327
Query: 360 AVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
A QG ++M+GQ + G++ + P H
Sbjct: 328 AAKTQGGHVYMWGQCR--GQSVILPHLTH 354
Score = 91.9 bits (218), Expect = 5e-18
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 39/296 (13%)
Query: 104 FHKFTDRRYRLIVSGC---TAGHSVLVSE-EGEAYTFGRNACGQLGFGDTVTRSVPELVP 159
F ++ +LI C +AG+ VL + E + G N CG LG GD + P +
Sbjct: 39 FSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLD 98
Query: 160 ELKGKNIIHAAVGR-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GT 216
L GK I + G H + T G V+ G N Q G G TT L P I N
Sbjct: 99 SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNG-TTNHGLVPCHISTNLSNK 157
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
+++V CG+ S++L +G + ++G GQ+G + + IP+++T
Sbjct: 158 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTG 205
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+Q +V ++CG +A+ + WG+ G G+LG ++ P
Sbjct: 206 CLQNK-----------VVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPC 254
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPV 386
+ G V+ V CG ++L + D+G ++ +G + G N YP PV
Sbjct: 255 RVAALQ--GIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV 308
Score = 90.2 bits (214), Expect = 1e-17
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ L H T+ + ++ C + HS++++ +GE + +G N GQ+G G TV + +P
Sbjct: 141 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIP 200
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L+ K ++ A G+ + V DTG VY G N +GQ GLGN+ Q P R+
Sbjct: 201 RRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ-PTPCRVAAL 259
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G + +V CG +++L G ++++G YGQLG
Sbjct: 260 QGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 295
Score = 69.3 bits (162), Expect = 3e-11
Identities = 67/278 (24%), Positives = 125/278 (44%), Gaps = 36/278 (12%)
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMIL- 231
+ L+ T ++ G N G GLG+ I +P R+ NG I + G+ ++L
Sbjct: 61 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-EPRRLDSLNGKKIACLSYGSGPHIVLA 119
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + ++G Y QLG+ T T+ L +P I+ T + +
Sbjct: 120 TTEGEVFTWGHNAYSQLGNGT------TNHGL------VPCHIS-----------TNLSN 156
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+++++CG+ H++ + S F+WG+ G++G ++ +PR + + V ++
Sbjct: 157 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGC-LQNKVVVTI 215
Query: 352 HCGGTYSLAVNDQGALFMFGQTKR----TGEANMYPKP--VHDLTGWNIKSVGTSNTSIV 405
CG +AV D G ++++G G + P P V L G ++ V +
Sbjct: 216 ACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTL 275
Query: 406 IAADDSLI-AWGVSPTYGELGMG-EINKSTAKPKEVSR 441
+ D+ + AWG + +YG+LG G + N+S P V +
Sbjct: 276 VLTDEGQVYAWGAN-SYGQLGTGNKSNQSYPTPVTVEK 312
Score = 66.9 bits (156), Expect = 1e-10
Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ C + V + GE Y +G N GQLG G++ + P V L+G + A G
Sbjct: 212 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY 271
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV 221
HTL +TD G VYA G N GQ G GN + Q PT + I+++
Sbjct: 272 AHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY-PTPVTVEKDRIIEI 318
Score = 55.2 bits (127), Expect = 5e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 12/178 (6%)
Query: 294 IVDLSCGNN-HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ H V + F+WG + +LG+ VP I + + V V
Sbjct: 105 IACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVA 163
Query: 353 CGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-HDLTGWN----IKSVGTSNTSIV 405
CG +SL + G +F +G + G + +P+ +TG + ++ +
Sbjct: 164 CGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM 223
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCD 462
D + WG + G+LG+G P V+ + + + +VA GY+HTL+L D
Sbjct: 224 AVVDTGEVYVWGYNGN-GQLGLGNSGNQPT-PCRVAALQGIRVQRVACGYAHTLVLTD 279
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H++++++EG+ Y +G N+ GQLG G+ +S P V K + I AA HT
Sbjct: 269 CGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 328
Query: 179 V-TDTGCVYACG 189
T G VY G
Sbjct: 329 AKTQGGHVYMWG 340
>BC038104-1|AAH38104.1| 355|Homo sapiens RCBTB1 protein protein.
Length = 355
Score = 95.9 bits (228), Expect = 3e-19
Identities = 77/284 (27%), Positives = 129/284 (45%), Gaps = 37/284 (13%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
++ V G +A ++ V++ E + FG N LG GD + VP+ + L GK I + G
Sbjct: 23 KVCVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYG 82
Query: 173 R-HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN--GTPIVKVGCGAEFSM 229
H L T+ G VYA G N Q G G TT Q + ++ N +V+V CG+ SM
Sbjct: 83 SGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIATVQVCTNLLIKQVVEVACGSHHSM 141
Query: 230 ILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQIT--LYIQKSKDGYIT 287
L +G + ++G GQ+G + + P+++T L+I++
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR------- 182
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+V ++CG ++A+ + WG+ G G+LG ++ P + +V
Sbjct: 183 ------VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV--C 234
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVH 387
V + CG ++LA+ D+G L+ +G TG N P H
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Score = 85.4 bits (202), Expect = 4e-16
Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 4/156 (2%)
Query: 97 THPNLYTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVP 155
T+ + T T+ + +V C + HS+ ++ +GE + +G N CGQ+G G T + P
Sbjct: 112 TNQGIATVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTP 171
Query: 156 ELVPE-LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KY 213
V L K ++ A G+ ++ V D G VY G N +GQ GLGN Q L P R+
Sbjct: 172 RKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQ-LTPVRVAAL 230
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
+ + ++ CG ++ L G L+++G YGQLG
Sbjct: 231 HSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
Score = 79.0 bits (186), Expect = 3e-14
Identities = 71/271 (26%), Positives = 112/271 (41%), Gaps = 37/271 (13%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHAAVGRHHTLFVTD 181
H +L +E+G Y +G N QLG G T + ++ L K ++ A G HH++ +
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIATVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 182 TGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT----PIVKVGCGAEFSMILDCNGNL 237
G V+A G N GQ G G+T Q PT K +V + CG SM + NG +
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQ---PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEV 202
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+ +G GQLG +G + H V + +
Sbjct: 203 YGWGYNGNGQLGLGNNGNQLTPVRVAALH------------------------SVCVNQI 238
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG HT+A+ ++WG +G+LG + + P I R V C +
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV--EKERVVEIAACHSAH 296
Query: 358 SLAVNDQGA-LFMFGQTKRTGEANMYPKPVH 387
+ A QG ++M+GQ + G++ + P H
Sbjct: 297 TSAAKTQGGHVYMWGQCR--GQSVILPHLTH 325
Score = 64.9 bits (151), Expect = 6e-10
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVG 172
R++ C S+ V + GE Y +G N GQLG G+ + P V L + G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 173 RHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGC--GAEFSMI 230
HTL +TD G +YA G N GQ G GN +L P I +V++ A S
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLGTGNKN-NLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 231 LDCNGNLHSFG 241
G+++ +G
Sbjct: 301 KTQGGHVYMWG 311
Score = 64.5 bits (150), Expect = 8e-10
Identities = 64/262 (24%), Positives = 115/262 (43%), Gaps = 33/262 (12%)
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC-NG 235
L+VTD V+ G N S G G+ ++ G I + G+ ++L +G
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
Query: 236 NLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIV 295
++++G Y QLG+ T + T + L I++ +V
Sbjct: 95 VVYAWGHNGYSQLGNGTTNQGIAT----------VQVCTNLLIKQ-------------VV 131
Query: 296 DLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG 355
+++CG++H++A+ + F+WG+ G++G ++ PR + + R V + CG
Sbjct: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR-VVGIACGQ 190
Query: 356 TYSLAVNDQGALFMFGQ--TKRTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
T S+AV D G ++ +G + G N + P V L + + + D
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTD 250
Query: 410 DSLI-AWGVSPTYGELGMGEIN 430
+ L+ AWG + TYG+LG G N
Sbjct: 251 EGLLYAWGAN-TYGQLGTGNKN 271
Score = 56.4 bits (130), Expect = 2e-07
Identities = 46/181 (25%), Positives = 82/181 (45%), Gaps = 12/181 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRA-FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVH 352
I LS G+ V + + ++WG G+ +LG+ ++ + + + + + V V
Sbjct: 76 IKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTT-NQGIATVQVCTNLLIKQVVEVA 134
Query: 353 CGGTYSLAVNDQGALFMFGQTK----RTGEANMYPKPVHDLTGWNIKSV---GTSNTSIV 405
CG +S+A+ G +F +G +G P P +IK V TS +
Sbjct: 135 CGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSM 194
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDNN 464
D+ + WG + G+LG+G N + P V+ + S+ + Q+ GY+HTL L D
Sbjct: 195 AVLDNGEVYGWGYNGN-GQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 465 I 465
+
Sbjct: 253 L 253
>X12654-1|CAA31182.1| 421|Homo sapiens protein ( Human mRNA for
cell cycle gene RCC1. ).
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>X06130-1|CAA29496.1| 421|Homo sapiens protein ( Human mRNA for
cell cycle gene RCC1. ).
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>D00591-1|BAA00469.1| 421|Homo sapiens RCC1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>CR407693-1|CAG28621.1| 421|Homo sapiens CHC1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>BC069198-1|AAH69198.1| 452|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 452
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 109 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 165
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 166 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 224
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 225 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 276
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 277 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 336
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 337 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 395
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 396 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 445
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 278 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 337
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 338 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 396
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 397 VFAWGMGTNYQLGTGQD 413
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 120
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 121 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 174
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 175 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 216
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 217 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 276
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 277 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 336
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 337 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 386
Score = 42.7 bits (96), Expect = 0.003
Identities = 38/143 (26%), Positives = 59/143 (41%), Gaps = 25/143 (17%)
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
H T+ G V G GQ GLG + KP + +V+ G ++ L +
Sbjct: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 116
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G ++SFG + G LG + TS + S E +P ++ L +
Sbjct: 117 GQVYSFGCNDEGALGRD-------TSVEGS---EMVPGKVEL--------------QEKV 152
Query: 295 VDLSCGNNHTVAIDSMKRAFSWG 317
V +S G++HT A+ R F WG
Sbjct: 153 VQVSAGDSHTAALTDDGRVFLWG 175
>BC036903-1|AAH36903.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>BC010067-1|AAH10067.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>BC007300-1|AAH07300.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>AL513497-2|CAI22287.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>AF498924-1|AAM21072.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 94.3 bits (224), Expect = 8e-19
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 29/352 (8%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---ELKGKNIIHAAVGRHHTLFV 179
H+V +S+ G+ Y+FG N G LG +V S E+VP EL+ K ++ + G HT +
Sbjct: 78 HTVCLSKSGQVYSFGCNDEGALGRDTSVEGS--EMVPGKVELQEK-VVQVSAGDSHTAAL 134
Query: 180 TDTGCVYACGD--NKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
TD G V+ G + +G GL + + P +++ + P+VKV G + ++L +G+L
Sbjct: 135 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDL 193
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
++ G E GQLG + + + +PK + L + S+ G+ V D
Sbjct: 194 YTLGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVMLKSRGSR-GH------VRFQDA 245
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
CG T AI + +G + +LG + +P+ + F + G +
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 358 SLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNTSIVIAADD 410
++ ++ +G + G+ + R G E P + L + + G S + D
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGAS-VGYAVTKDG 364
Query: 411 SLIAWGVSPTYGELGMGEINKSTAKPKEV--SRMDSLGITQVAMGYSHTLLL 460
+ AWG+ Y +LG G+ ++ P E+ ++++ + V+ G HT+LL
Sbjct: 365 RVFAWGMGTNY-QLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 60.1 bits (139), Expect = 2e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG--KNIIHAAVGRHHT 176
C A + +S EG Y FG + QLG T + +P+ + K K+ + + G+HHT
Sbjct: 247 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 306
Query: 177 LFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGN 236
+ + G Y+ G + G+ GLG + PT I + V CGA + +G
Sbjct: 307 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLIS-RLPAVSSVACGASVGYAVTKDGR 365
Query: 237 LHSFGMPEYGQLGHNTD 253
+ ++GM QLG D
Sbjct: 366 VFAWGMGTNYQLGTGQD 382
Score = 56.4 bits (130), Expect = 2e-07
Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 52/352 (14%)
Query: 128 SEEGEAYTFGRNACGQLGFGDTVT-RSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVY 186
+E G T G+ GQLG G+ V R P LV ++++ A G HT+ ++ +G VY
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSKSGQVY 89
Query: 187 ACGDNKSGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
+ G N G G + + P +++ +V+V G + L +G + +
Sbjct: 90 SFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAALTDDGRVFL-----W 143
Query: 246 GQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTV 305
G N + K S +P Q+ L DV +V ++ GN+H V
Sbjct: 144 GSFRDNNGVIGLLEPMKKSM----VPVQVQL--------------DVPVVKVASGNDHLV 185
Query: 306 AIDSMKRAFSWGFGGFGRLGHAEQKDEN-----------VPRLIKYFDTVGRG---VRSV 351
+ + ++ G G G+LG + N VP+ + RG +
Sbjct: 186 MLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA 245
Query: 352 HCGGTYSLAVNDQGALFMFG-----QTKRTG-EANMYPKPVHDLTGWNIKSVGTS-NTSI 404
CG ++ A++ +G ++ FG Q G E+ P+ + VG S
Sbjct: 246 FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHH 305
Query: 405 VIAADDSLIAWGVS-PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYS 455
+ D A+ + YG LG+GE + + P +SR+ + ++ VA G S
Sbjct: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGAS 355
Score = 43.6 bits (98), Expect = 0.002
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 33/167 (19%)
Query: 152 RSVP-ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTR 210
RS P + +P+ K + H R H+ T+ G V G GQ GLG + KP
Sbjct: 10 RSPPADAIPKSKKVKVSH----RSHS---TEPGLVLTLGQGDVGQLGLGENVMERKKPAL 62
Query: 211 IKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETI 270
+ +V+ G ++ L +G ++SFG + G LG + TS + S E +
Sbjct: 63 VSI-PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD-------TSVEGS---EMV 111
Query: 271 PKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWG 317
P ++ L +V +S G++HT A+ R F WG
Sbjct: 112 PGKVEL--------------QEKVVQVSAGDSHTAALTDDGRVFLWG 144
>AB046813-1|BAB13419.1| 953|Homo sapiens KIAA1593 protein protein.
Length = 953
Score = 93.9 bits (223), Expect = 1e-18
Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 26/229 (11%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
+++ C HS+ +S+ E + +G+N GQLG G D ++ P+L+ L G + A
Sbjct: 34 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 93
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
G H+ +T +G ++ G NK GQ GL + + + IV + CG + + L
Sbjct: 94 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 153
Query: 232 DCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G + +FG YGQLGHN+ TS +++ P+++ + G I
Sbjct: 154 TKEGGVFTFGAGGYGQLGHNS------TSHEIN------PRKVFELM-----GSI----- 191
Query: 292 VTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ +++CG HT A + S R +S+G GG G+LG + P +K
Sbjct: 192 --VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 238
Score = 86.6 bits (205), Expect = 2e-16
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 28/216 (12%)
Query: 158 VPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGT 216
+ L I+ A G +H+L ++ V+ G NK GQ GLG + P +K G
Sbjct: 27 IKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGI 86
Query: 217 PIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITL 276
P ++V G S +L +G + +G ++GQLG N + +V +
Sbjct: 87 PFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPN---------------- 130
Query: 277 YIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPR 336
+ KS ++ IV + CG +HT A+ F++G GG+G+LGH E PR
Sbjct: 131 -LLKS-------LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPR 182
Query: 337 LIKYFDTVGRGVRSVHCGGTYSLA-VNDQGALFMFG 371
K F+ +G V + CG ++ A V G ++ FG
Sbjct: 183 --KVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 216
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 136 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 195
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 196 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 246
Score = 62.5 bits (145), Expect = 3e-09
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 14/181 (7%)
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTV 344
I + D+ IV ++CG H++A+ F WG +G+LG + K + P+L+K +
Sbjct: 27 IKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLL 84
Query: 345 GRGVRSVHCGGTYSLAVNDQGALF-----MFGQTKRTGEANMY-PKPVHDLTGWNIKSV- 397
G V GG +S + GA+F FGQ E + Y P + L I +
Sbjct: 85 GIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYIC 144
Query: 398 -GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSH 456
G +T+ + + + +G YG+LG + P++V + +T++A G H
Sbjct: 145 CGEDHTA-ALTKEGGVFTFGAG-GYGQLGHNSTSHE-INPRKVFELMGSIVTEIACGRQH 201
Query: 457 T 457
T
Sbjct: 202 T 202
Score = 33.5 bits (73), Expect = 1.7
Identities = 16/58 (27%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
S+ ++ + WG + YG+LG+G K P+ + + + QVA G +H+ +L
Sbjct: 45 SLALSKASEVFCWGQNK-YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 101
>AB027289-1|BAA88519.1| 1024|Homo sapiens cyclin-E binding protein 1
protein.
Length = 1024
Score = 93.1 bits (221), Expect = 2e-18
Identities = 67/230 (29%), Positives = 118/230 (51%), Gaps = 28/230 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTV-TRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S+ GE + +G+N GQLG G + + P++V L G + +
Sbjct: 139 KIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISA 198
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMI 230
G H++ ++ +G +Y+ G N+ GQ GLG+T + P+ I+ + + V CG S +
Sbjct: 199 GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSAL 257
Query: 231 LDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVK 290
L +G L +FG ++GQLGHN+ T +L P + + GY
Sbjct: 258 LTQDGLLFTFGAGKHGQLGHNS------TQNELR------PCLVAELV-----GY----- 295
Query: 291 DVTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ ++CG HT+A + + + FS+G G G+LG+ +D+ +P +K
Sbjct: 296 --RVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVK 343
Score = 85.4 bits (202), Expect = 4e-16
Identities = 63/216 (29%), Positives = 102/216 (47%), Gaps = 28/216 (12%)
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKY-NGTPIV 219
L+ K II G +H+L ++ G ++A G N GQ G+G P P +++ G P+
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
++ G SM L +GN++S+G E GQLG H E+
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLG--------------HTES---------- 230
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
K I + + + ++CG +H+ + F++G G G+LGH ++E P L+
Sbjct: 231 KDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVA 290
Query: 340 YFDTVGRGVRSVHCGGTYSLA-VNDQGALFMFGQTK 374
+ VG V + CG ++LA V+D G +F FG K
Sbjct: 291 --ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGK 324
Score = 75.4 bits (177), Expect = 4e-13
Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTL- 177
C HS L++++G +TFG GQLG T P LV EL G + A GR HTL
Sbjct: 250 CGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLA 309
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV-GCGAEFSMILDCNGN 236
+V+D G V++ G K GQ G G T Q++ P +K + + +K+ +E +I+ GN
Sbjct: 310 YVSDLGKVFSFGSGKDGQLGNGGTRDQLM-PLPVKVSSSEELKLESHTSEKELIMIAGGN 368
Score = 58.8 bits (136), Expect = 4e-08
Identities = 60/220 (27%), Positives = 99/220 (45%), Gaps = 38/220 (17%)
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
I+++ CG S+ L G L ++G +GQLG G+ F ++T QI +
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGV---GRKFPSTTT---------PQIVEH 187
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGR--LGHAEQKDENVP 335
+ V + +S G H++A+ +SWG G+ LGH E KD+ P
Sbjct: 188 LA-----------GVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDD--P 234
Query: 336 RLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYPKPVHDL 389
LI+ D + V V CGG++S + G LF FG K + + + P V +L
Sbjct: 235 SLIEGLD--NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAEL 292
Query: 390 TGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G+ + + G +T ++ + ++G S G+LG G
Sbjct: 293 VGYRVTQIACGRWHTLAYVSDLGKVFSFG-SGKDGQLGNG 331
Score = 54.8 bits (126), Expect = 6e-07
Identities = 37/177 (20%), Positives = 84/177 (47%), Gaps = 10/177 (5%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRG 347
+++ I+ ++CG+ H++A+ F+WG G+LG + P+++++ G
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHL--AGVP 192
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK--RTG----EANMYPKPVHDLTGWNIKSVGTSN 401
+ + G +S+A++ G ++ +G+ + + G E+ P + L ++ V
Sbjct: 193 LAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252
Query: 402 TSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+ + D L+ + +G+LG ++ +P V+ + +TQ+A G HTL
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGHNS-TQNELRPCLVAELVGYRVTQIACGRWHTL 308
Score = 37.5 bits (83), Expect = 0.10
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
S+ ++ L AWG + +G+LG+G ST P+ V + + + Q++ G +H++ L
Sbjct: 150 SLALSKGGELFAWGQN-LHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206
>AY337518-1|AAR00320.1| 1024|Homo sapiens HECT E3 ubiquitin ligase
protein.
Length = 1024
Score = 91.9 bits (218), Expect = 5e-18
Identities = 67/230 (29%), Positives = 117/230 (50%), Gaps = 28/230 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTV-TRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S+ GE + +G+N GQLG G + + P++V L G + +
Sbjct: 139 KIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISA 198
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMI 230
G H+ ++ +G +Y+ G N+ GQ GLG+T + P+ I+ + + V CG S +
Sbjct: 199 GEAHSTALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSAL 257
Query: 231 LDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVK 290
L +G L +FG ++GQLGHN+ T +L P + + GY
Sbjct: 258 LTQDGLLFTFGAGKHGQLGHNS------TQNELR------PCLVAELV-----GY----- 295
Query: 291 DVTIVDLSCGNNHTVA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
+ ++CG HT+A + + + FS+G G G+LG+ +D+ +P +K
Sbjct: 296 --RVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVK 343
Score = 83.0 bits (196), Expect = 2e-15
Identities = 62/216 (28%), Positives = 101/216 (46%), Gaps = 28/216 (12%)
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKY-NGTPIV 219
L+ K II G +H+L ++ G ++A G N GQ G+G P P +++ G P+
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
++ G S L +GN++S+G E GQLG H E+
Sbjct: 195 QISAGEAHSTALSMSGNIYSWGKNECGQLGLG--------------HTES---------- 230
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
K I + + + ++CG +H+ + F++G G G+LGH ++E P L+
Sbjct: 231 KDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVA 290
Query: 340 YFDTVGRGVRSVHCGGTYSLA-VNDQGALFMFGQTK 374
+ VG V + CG ++LA V+D G +F FG K
Sbjct: 291 --ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGK 324
Score = 75.4 bits (177), Expect = 4e-13
Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTL- 177
C HS L++++G +TFG GQLG T P LV EL G + A GR HTL
Sbjct: 250 CGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLA 309
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKV-GCGAEFSMILDCNGN 236
+V+D G V++ G K GQ G G T Q++ P +K + + +K+ +E +I+ GN
Sbjct: 310 YVSDLGKVFSFGSGKDGQLGNGGTRDQLM-PLPVKVSSSEELKLESHTSEKELIMIAGGN 368
Score = 58.4 bits (135), Expect = 5e-08
Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 38/220 (17%)
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
I+++ CG S+ L G L ++G +GQLG G+ F ++T QI +
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGV---GRKFPSTTT---------PQIVEH 187
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGR--LGHAEQKDENVP 335
+ V + +S G H+ A+ +SWG G+ LGH E KD+ P
Sbjct: 188 LA-----------GVPLAQISAGEAHSTALSMSGNIYSWGKNECGQLGLGHTESKDD--P 234
Query: 336 RLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYPKPVHDL 389
LI+ D + V V CGG++S + G LF FG K + + + P V +L
Sbjct: 235 SLIEGLD--NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAEL 292
Query: 390 TGWNIKSV--GTSNTSIVIAADDSLIAWGVSPTYGELGMG 427
G+ + + G +T ++ + ++G S G+LG G
Sbjct: 293 VGYRVTQIACGRWHTLAYVSDLGKVFSFG-SGKDGQLGNG 331
Score = 53.6 bits (123), Expect = 1e-06
Identities = 37/177 (20%), Positives = 83/177 (46%), Gaps = 10/177 (5%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRG 347
+++ I+ ++CG+ H++A+ F+WG G+LG + P+++++ G
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHL--AGVP 192
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTK--RTG----EANMYPKPVHDLTGWNIKSVGTSN 401
+ + G +S A++ G ++ +G+ + + G E+ P + L ++ V
Sbjct: 193 LAQISAGEAHSTALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252
Query: 402 TSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+ + D L+ + +G+LG ++ +P V+ + +TQ+A G HTL
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGHNS-TQNELRPCLVAELVGYRVTQIACGRWHTL 308
Score = 36.7 bits (81), Expect = 0.18
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSH-TLLLC 461
S+ ++ L AWG + +G+LG+G ST P+ V + + + Q++ G +H T L
Sbjct: 150 SLALSKGGELFAWGQN-LHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSTALSM 208
Query: 462 DNNI 465
NI
Sbjct: 209 SGNI 212
>X97668-1|CAA66258.1| 815|Homo sapiens XLRP3 protein.
Length = 815
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>U57629-1|AAC50481.1| 815|Homo sapiens retinitis pigmentosa GTPase
regulator protein.
Length = 815
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>BC031624-1|AAH31624.1| 480|Homo sapiens RPGR protein protein.
Length = 480
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>AL606748-2|CAI95407.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator protein.
Length = 815
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>AK223491-1|BAD97211.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator variant protein.
Length = 815
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
>AJ238395-1|CAB54002.1| 646|Homo sapiens RPGR protein protein.
Length = 646
Score = 91.1 bits (216), Expect = 8e-18
Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
+ V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.2 bits (209), Expect = 6e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GKPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 87.0 bits (206), Expect = 1e-16
Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
GK + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.0 bits (196), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------KPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 57.6 bits (133), Expect = 9e-08
Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 34/258 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM--YPKPVHDL 389
+I +F T ++ + G S A+ + G LFM+G + G N+ P
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 390 TGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGI 447
G + + S + D L +G P G+LG+ ++ + P+ VS + +
Sbjct: 188 IGKPVSWISCGYYHSAFVTTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-KV 245
Query: 448 TQVAMGYSHTLLLCDNNI 465
QVA G HT++L +N +
Sbjct: 246 IQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9
protein.
Length = 979
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 356 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 529
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 530 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 583
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 584 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 640
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Score = 54.8 bits (126), Expect = 6e-07
Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ +R V CG
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIRQVSCG 434
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 495 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 598 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 655
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 656 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 546
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 604
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 605 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 649
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 521 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 581 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 640
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
>BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis
gene a)- related kinase 9 protein.
Length = 979
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 356 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 529
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 530 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 583
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 584 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 640
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Score = 54.8 bits (126), Expect = 6e-07
Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ +R V CG
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIRQVSCG 434
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 495 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 598 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 655
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 656 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 546
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 604
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 605 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 649
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 521 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 581 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 640
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
>AY653203-1|AAV66897.1| 322|Homo sapiens truncated HERC6 protein.
Length = 322
Score = 90.6 bits (215), Expect = 1e-17
Identities = 65/238 (27%), Positives = 111/238 (46%), Gaps = 26/238 (10%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPELKGKNIIHAAVGRHHTL 177
C HS+ V +G + +G + GQLG G+ S P+ + L II + G +H+L
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 178 FVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGN 236
++ V++ G N GQ GLG P P R++ G P+ +V G S L G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 237 LHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVD 296
SFG G N+ G +L+ +P +Q +K + +K++ +V
Sbjct: 202 --SFGW------GSNSAG-------QLALSGRNVP------VQSNKPLSVGALKNLGVVY 240
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
+SCG+ HT + + F++G G+LG++ ++ P+L++ D + V + CG
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL---VSQIDCG 295
Score = 79.0 bits (186), Expect = 3e-14
Identities = 69/267 (25%), Positives = 110/267 (41%), Gaps = 30/267 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+L+ + G N+ GQLG +PE + L+ + + G+ H+L V
Sbjct: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHK 93
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSMILDCNGNLHSFG 241
G V+A G GQ G+G P +I N I++V CG S+ L + + S+G
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG 153
Query: 242 MPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGN 301
+GQLG GK F P Q + +S +G + + ++ G
Sbjct: 154 KNSHGQLGL---GKEF-------------PSQASPQRVRSLEG-------IPLAQVAAGG 190
Query: 302 NHTVAIDSMKRAFSWGFGGFGRL---GHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYS 358
H+ A+ +F WG G+L G N P + + GV + CG ++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL--GVVYISCGDAHT 248
Query: 359 LAVNDQGALFMFGQTKRTGEANMYPKP 385
+ G +F FG R+G+ P P
Sbjct: 249 AVLTQDGKVFTFGD-NRSGQLGYSPTP 274
Score = 73.3 bits (172), Expect = 2e-12
Identities = 82/302 (27%), Positives = 137/302 (45%), Gaps = 39/302 (12%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-V 221
G ++ AA G H+L + V +CGDN GQ G L P I+ T IV V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVDLV 80
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG E S+ + G + ++G GQLG G++ ++SF PK+I
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEGQLGI---GEF----KEISF----TPKKIMT----- 124
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKY 340
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++
Sbjct: 125 -------LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS 177
Query: 341 FDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIK 395
+ G + V GG +S A++ G F +G + G+ + + PV L+ +K
Sbjct: 178 LE--GIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 396 SVGTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVA 451
++G S A L G T+G+ G++ S P+ V R+D L ++Q+
Sbjct: 235 NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQID 293
Query: 452 MG 453
G
Sbjct: 294 CG 295
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 129 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 188
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLGYS 271
Score = 65.7 bits (153), Expect = 3e-10
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%)
Query: 291 DVTIVDL-SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN-VPRLIKYFDTVGRGV 348
+ IVDL SCG H++A+ R F+WG G G+LG E K+ + P+ I + + +
Sbjct: 73 ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK--I 130
Query: 349 RSVHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSN 401
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 190
Query: 402 T-SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTL 458
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT
Sbjct: 191 AHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTA 249
Query: 459 LL 460
+L
Sbjct: 250 VL 251
Score = 64.1 bits (149), Expect = 1e-09
Identities = 47/175 (26%), Positives = 86/175 (49%), Gaps = 11/175 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ + G H++ + + R S G G+LG + +P I+ +T+ V V C
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI--VDLVSC 82
Query: 354 GGTYSLAVNDQGALFMFGQTK--RTG-----EANMYPKPVHDLTGWNIKSVGTSNT-SIV 405
G +SLAV +G +F +G + G E + PK + L I V + S+
Sbjct: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 143 LSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Score = 43.2 bits (97), Expect = 0.002
Identities = 16/50 (32%), Positives = 30/50 (60%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG 163
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G
Sbjct: 238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDG 287
>AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERCC1
protein.
Length = 979
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 356 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 416 QPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 529
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 530 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 583
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 584 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 640
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Score = 52.8 bits (121), Expect = 3e-06
Identities = 42/175 (24%), Positives = 74/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ + V CG
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIHQVSCG 434
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 495 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 598 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 655
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 656 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 546
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 604
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 605 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 649
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 521 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 581 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 640
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
>AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek8
protein.
Length = 979
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 356 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 416 QPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 529
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 530 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 583
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 584 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 640
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Score = 52.8 bits (121), Expect = 3e-06
Identities = 42/175 (24%), Positives = 74/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ + V CG
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIHQVSCG 434
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 495 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 547
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 598 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 655
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 656 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 546
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 604
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 605 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 649
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 521 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 581 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 640
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 641 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
>AC007055-4|AAD31939.1| 414|Homo sapiens protein ( Homo sapiens
chromosome 14 clone BAC 201F1 map 14q24.3, complete
sequence. ).
Length = 414
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 26 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 85
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 86 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 145
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 146 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 199
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 200 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 253
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 254 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 310
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 311 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 345
Score = 54.8 bits (126), Expect = 6e-07
Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ +R V CG
Sbjct: 47 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIRQVSCG 104
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 105 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 164
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 165 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 217
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 268 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 325
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 326 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 357
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 157 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 216
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 217 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 274
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 275 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 319
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 320 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 352
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 191 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 250
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 251 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 310
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 311 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 352
>AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein.
Length = 1011
Score = 90.6 bits (215), Expect = 1e-17
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 106 KFTDRRYRLIVSGCTAG-------HSVLVSEEGEAYTF-----GRNACGQLGFGDTVTRS 153
K T ++ +I SGC+A H +V+ E E YT+ G GQLG GD +
Sbjct: 388 KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 447
Query: 154 VPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTT-PQILKPTRIK 212
P+ V +L+GK I + G T+ VTD G +YA G + G G+ P++L+P ++
Sbjct: 448 QPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 507
Query: 213 -YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP 271
+ P+ +V CG ++L N ++S+G EYG+LG +++ Y+ T K+ +P
Sbjct: 508 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY-TPQKVD-----VP 561
Query: 272 KQ-ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK 330
K I + +Q DG + + L+CG N + + + S G + E
Sbjct: 562 KALIIVAVQCGCDGTFLLTQSGKV--LACGLNEFNKL-GLNQCMS---GIINHEAYHEVP 615
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMYPKPV-- 386
L K +R++ G T++ A++++G L FG K + G N Y K +
Sbjct: 616 YTTSFTLAKQLSFY--KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGI 672
Query: 387 ----HDLTGWNIKSVGTSNTSIVIAADDS-LIAWG 416
L G + V + + A DD+ + AWG
Sbjct: 673 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 707
Score = 52.8 bits (121), Expect = 3e-06
Identities = 42/175 (24%), Positives = 74/175 (42%), Gaps = 18/175 (10%)
Query: 300 GNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
GN H + K ++W G G+LGH ++ P+ ++ G+ + V CG
Sbjct: 409 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ--GKAIHQVSCG 466
Query: 355 GTYSLAVNDQGALFMFGQ--------TKRTGEANMYPKPVHDLTGWNIKSVGT-SNTSIV 405
+++ V D+G L+ FG K G + P ++ ++ V N +V
Sbjct: 467 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 526
Query: 406 IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ + + +WG YG LG+ + + P++V +L I V G T LL
Sbjct: 527 LTRNKEVYSWGCG-EYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL 579
Score = 52.8 bits (121), Expect = 3e-06
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 111 RYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTR-SVPELVPELKGKNIIHA 169
+ R I G T H+ + E G TFG N CGQLG G+ R + L L GK +I
Sbjct: 630 KIRTIAPGKT--HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV 687
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNT 201
+ G T+ TD ++A G+ +G+ + T
Sbjct: 688 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 719
Score = 52.4 bits (120), Expect = 3e-06
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 24/213 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C H V+++ E Y++G G+LG P+ V K I+ G T
Sbjct: 519 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFL 578
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE----FSMILDCN 234
+T +G V ACG N+ + GL I+ Y+ P A+ + +
Sbjct: 579 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEA--YHEVPYTTSFTLAKQLSFYKIRTIAP 636
Query: 235 GNLHSFGMPEYGQL---GHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKD 291
G H+ + E G+L G N G+ V + K K++ + + P+
Sbjct: 637 GKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGINLLGG------PLGG 681
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
++ +SCG+ T+A F+WG GG GRL
Sbjct: 682 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 714
Score = 43.2 bits (97), Expect = 0.002
Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 15/162 (9%)
Query: 102 YTFHKFTDRRYRLIVS-GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVT--------R 152
YT K + +IV+ C + L+++ G+ G N +LG ++
Sbjct: 553 YTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 612
Query: 153 SVP-----ELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQI-L 206
VP L +L I A G+ HT + + G + G NK GQ G+GN ++ +
Sbjct: 613 EVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI 672
Query: 207 KPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
G +++V CG EF++ + ++ ++G G+L
Sbjct: 673 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 714
>AJ318463-1|CAC86116.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator protein.
Length = 815
Score = 90.2 bits (214), Expect = 1e-17
Identities = 79/305 (25%), Positives = 137/305 (44%), Gaps = 39/305 (12%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVG-CGA 225
+H + G H+ VT +Y G N GQ GLG+ + I KPT +K VK+ CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSA-ISKPTCVKALKPEKVKLAACGR 96
Query: 226 EFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGY 285
+++ GN+++ G GQLG T + +FH I+ + + K
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEHK--- 141
Query: 286 ITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVG 345
I LS G+N + A+ R F WG G++G + VP+ + T+G
Sbjct: 142 --------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV----TIG 189
Query: 346 RGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANMY------PKPVHDLTGWNIKSV 397
V + CG +S V G L++FG+ + + G N P+ V ++ + V
Sbjct: 190 NPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQV 248
Query: 398 GTSNTSIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
V+ ++++ +G+ +G+LG+G T++PK + + I+ ++ G +HT
Sbjct: 249 ACGGEHTVVLTENAVYTFGLGQ-FGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Query: 458 LLLCD 462
L+ D
Sbjct: 308 ALITD 312
Score = 88.6 bits (210), Expect = 4e-17
Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 30/258 (11%)
Query: 116 VSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKN-IIHAAVGRH 174
++ C H+++ +E G Y G N GQLG GDT R+ ++ ++ I + G +
Sbjct: 91 LAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 175 HTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCN 234
+ +T+ G ++ GDN GQ GL N + + P ++ G P+ + CG S + +
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGLKNVS-NVCVPQQVTI-GNPVSWISCGYYHSAFVTTD 208
Query: 235 GNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTI 294
G L+ FG PE G+LG + + L H P+ ++ +K +
Sbjct: 209 GELYVFGEPENGKLG--------LPNQLLGNH--RTPQLVSEIPEK-------------V 245
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKYFDTVGRGVRSVHC 353
+ ++CG HTV + + +++G G FG+LG E + P++I+ + + + + C
Sbjct: 246 IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIE--NIRDQTISYISC 302
Query: 354 GGTYSLAVNDQGALFMFG 371
G ++ + D G ++ FG
Sbjct: 303 GENHTALITDIGLMYTFG 320
Score = 85.0 bits (201), Expect = 5e-16
Identities = 72/260 (27%), Positives = 121/260 (46%), Gaps = 33/260 (12%)
Query: 103 TFH--KFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPE 160
TFH F +++ + S ++E+G + +G N+ GQ+G + VP+ V
Sbjct: 129 TFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI 188
Query: 161 LKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGN-TTPQILKPTRIKYNGTPIV 219
G + + G +H+ FVT G +Y G+ ++G+ GL N P + ++
Sbjct: 189 --GNPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246
Query: 220 KVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQ 279
+V CG E +++L N +++FG+ ++GQLG T F FET
Sbjct: 247 QVACGGEHTVVLTENA-VYTFGLGQFGQLGLGT------------FLFET---------- 283
Query: 280 KSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN--VPRL 337
S+ I ++D TI +SCG NHT I + +++G G G+LG + N +P L
Sbjct: 284 -SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 338 IKYFDTVGRGVRSVHCGGTY 357
F + V+ V CGG +
Sbjct: 343 CSNF--LRFIVKLVACGGCH 360
Score = 83.4 bits (197), Expect = 2e-15
Identities = 83/318 (26%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C HS +V+ + Y FG N GQLG G S P V LK + + AA GR+HTL
Sbjct: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQ-ILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNL 237
T+ G VYA G N GQ GLG+T + + I ++ G+ S L +G L
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRL 161
Query: 238 HSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDL 297
+G GQ+G V++ +P+Q+T+ PV +
Sbjct: 162 FMWGDNSEGQIGLKN-----VSNV-------CVPQQVTIG---------NPVSWI----- 195
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ--KDENVPRLIKYFDTVGRGVRSVHCGG 355
SCG H+ + + + +G G+LG Q + P+L+ + V V CGG
Sbjct: 196 SCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV---SEIPEKVIQVACGG 252
Query: 356 TYSLAVNDQGA-LFMFGQTKRTGEANMY-----PKPVHDLTGWNIKSVGTSNTSIVIAAD 409
+++ + + F GQ + G PK + ++ I + + D
Sbjct: 253 EHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Query: 410 DSLIAWGVSPTYGELGMG 427
L+ +G+LG+G
Sbjct: 313 IGLMYTFGDGRHGKLGLG 330
Score = 58.0 bits (134), Expect = 7e-08
Identities = 64/259 (24%), Positives = 109/259 (42%), Gaps = 36/259 (13%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N P V + CG E S ++ N L+ FG +GQLG +
Sbjct: 34 NDVP-VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAI----------------- 75
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDEN 333
SK + +K + +CG NHT+ ++ G G+LG + ++ N
Sbjct: 76 -------SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERN 128
Query: 334 VPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK--RTGEANM----YPKPVH 387
+I +F T ++ + G S A+ + G LFM+G + G N+ P+ V
Sbjct: 129 TFHVISFF-TSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT 187
Query: 388 DLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLG 446
+ S G +++ V D L +G P G+LG+ ++ + P+ VS +
Sbjct: 188 IGNPVSWISCGYYHSAFV-TTDGELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPE-K 244
Query: 447 ITQVAMGYSHTLLLCDNNI 465
+ QVA G HT++L +N +
Sbjct: 245 VIQVACGGEHTVVLTENAV 263
Score = 31.5 bits (68), Expect = 6.8
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 15/102 (14%)
Query: 363 DQGALFMFGQTK--RTGEANMYPK---PVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGV 417
D GA+F FG++K + K PVH S G + S V+ ++ L +G
Sbjct: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVH-------LSCGDEH-SAVVTGNNKLYMFG- 60
Query: 418 SPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLL 459
S +G+LG+G + +KP V + + A G +HTL+
Sbjct: 61 SNNWGQLGLGS-KSAISKPTCVKALKPEKVKLAACGRNHTLV 101
>AF225407-1|AAO27483.1| 409|Homo sapiens HERC2 protein.
Length = 409
Score = 90.2 bits (214), Expect = 1e-17
Identities = 67/240 (27%), Positives = 111/240 (46%), Gaps = 28/240 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR--HHTLFVT 180
HS V+ G+ YT+G+ G+LG D+ + P+LV L+G ++ A G TL +T
Sbjct: 6 HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLT 65
Query: 181 DTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSF 240
D V++ GD G+ G G + + G +VKV CG++FS+ L +G ++++
Sbjct: 66 DDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTW 125
Query: 241 GMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCG 300
G +Y +LGH +D H P+Q+ +Q K ++ ++ G
Sbjct: 126 GKGDYHRLGHGSDD-----------HVRR-PRQVQ-GLQGKK-----------VIAIATG 161
Query: 301 NNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA 360
+ H V ++WG G+LG PRL+ G+ V V CG ++LA
Sbjct: 162 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQ--GKKVNRVACGSAHTLA 219
Score = 74.9 bits (176), Expect = 6e-13
Identities = 50/174 (28%), Positives = 85/174 (48%), Gaps = 13/174 (7%)
Query: 294 IVDLSCGNN--HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+VD++CG+ T+ + +SWG G +G+LG VP +K G GV V
Sbjct: 49 VVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVP--MKIDSLTGLGVVKV 106
Query: 352 HCGGTYSLAVNDQGALFMFGQTK--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIV 405
CG +S+A+ GA++ +G+ R G + P+ V L G + ++ T + V
Sbjct: 107 ECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCV 166
Query: 406 IAADDSLI-AWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+D + WG + G+LG G N + +P+ V+ + + +VA G +HTL
Sbjct: 167 CCTEDGEVYTWGDNDE-GQLGDGTTN-AIQRPRLVAALQGKKVNRVACGSAHTL 218
Score = 63.7 bits (148), Expect = 1e-09
Identities = 38/112 (33%), Positives = 56/112 (50%), Gaps = 2/112 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + SV +++ G YT+G+ +LG G P V L+GK +I A G H +
Sbjct: 108 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVC 167
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI-KYNGTPIVKVGCGAEFSM 229
T+ G VY GDN GQ G G TT I +P + G + +V CG+ ++
Sbjct: 168 CTEDGEVYTWGDNDEGQLGDG-TTNAIQRPRLVAALQGKKVNRVACGSAHTL 218
Score = 58.8 bits (136), Expect = 4e-08
Identities = 40/168 (23%), Positives = 75/168 (44%), Gaps = 13/168 (7%)
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGG-- 355
+ G H+ + + ++WG G +GRLGH++ +D+ P+L++ G V + CG
Sbjct: 1 AAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ--GHRVVDIACGSGD 58
Query: 356 TYSLAVNDQGALFM-----FGQTKRTG-EANMYPKPVHDLTGWNIKSVGT-SNTSIVIAA 408
+L + D ++ +G+ R G + P + LTG + V S S+ +
Sbjct: 59 AQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 118
Query: 409 DDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSH 456
++ WG Y LG G + +P++V + + +A G H
Sbjct: 119 SGAVYTWG-KGDYHRLGHGS-DDHVRRPRQVQGLQGKKVIAIATGSLH 164
Score = 50.8 bits (116), Expect = 1e-05
Identities = 30/144 (20%), Positives = 70/144 (48%), Gaps = 4/144 (2%)
Query: 112 YRLIVSGCTAG--HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
+R++ C +G ++ ++++ +++G G+LG G + VP + L G ++
Sbjct: 47 HRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKV 106
Query: 170 AVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFS 228
G ++ +T +G VY G + G G + + +P +++ G ++ + G+
Sbjct: 107 ECGSQFSVALTKSGAVYTWGKGDYHRLGHG-SDDHVRRPRQVQGLQGKKVIAIATGSLHC 165
Query: 229 MILDCNGNLHSFGMPEYGQLGHNT 252
+ +G ++++G + GQLG T
Sbjct: 166 VCCTEDGEVYTWGDNDEGQLGDGT 189
>AL356741-1|CAH74146.1| 907|Homo sapiens hect domain and RLD 4
protein.
Length = 907
Score = 85.8 bits (203), Expect = 3e-16
Identities = 61/216 (28%), Positives = 101/216 (46%), Gaps = 26/216 (12%)
Query: 126 LVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGC 184
+ E + +G+N GQLG G D ++ P+L+ L G + A G H+ +T +G
Sbjct: 1 MAESASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 60
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPE 244
++ G NK GQ GL + + + IV + CG + + L G + +FG
Sbjct: 61 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG 120
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
YGQLGHN+ TS +++ P+++ + G I + +++CG HT
Sbjct: 121 YGQLGHNS------TSHEIN------PRKVFELM-----GSI-------VTEIACGRQHT 156
Query: 305 VA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
A + S R +S+G GG G+LG + P +K
Sbjct: 157 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 192
Score = 78.6 bits (185), Expect = 5e-14
Identities = 41/128 (32%), Positives = 67/128 (52%), Gaps = 1/128 (0%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS +++ G + +GRN GQLG D R VP L+ L+ + I++ G HT +T
Sbjct: 51 HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 110
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF-SMILDCNGNLHSFG 241
G V+ G GQ G +T+ +I + G+ + ++ CG + S + +G ++SFG
Sbjct: 111 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
Query: 242 MPEYGQLG 249
+ GQLG
Sbjct: 171 LGGNGQLG 178
Score = 76.2 bits (179), Expect = 2e-13
Identities = 58/189 (30%), Positives = 86/189 (45%), Gaps = 28/189 (14%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G NK GQ GLG + P +K G P ++V G S +L +G + +G
Sbjct: 8 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 67
Query: 244 EYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNH 303
++GQLG N + +V + S L QK IV + CG +H
Sbjct: 68 KFGQLGLNDENDRYVPNLLKS-----------LRSQK-------------IVYICCGEDH 103
Query: 304 TVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA-VN 362
T A+ F++G GG+G+LGH E PR K F+ +G V + CG ++ A V
Sbjct: 104 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPR--KVFELMGSIVTEIACGRQHTSAFVP 161
Query: 363 DQGALFMFG 371
G ++ FG
Sbjct: 162 SSGRIYSFG 170
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 90 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 149
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 150 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 200
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/144 (23%), Positives = 68/144 (47%), Gaps = 11/144 (7%)
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+ + ++ G H+ + F WG FG+LG ++ D VP L+K + + + +
Sbjct: 40 IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS--QKIVYI 97
Query: 352 HCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV--GTSNTS 403
CG ++ A+ +G +F F GQ ++ + P+ V +L G + + G +TS
Sbjct: 98 CCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTS 157
Query: 404 IVIAADDSLIAWGVSPTYGELGMG 427
+ + + ++G+ G+LG G
Sbjct: 158 AFVPSSGRIYSFGLGGN-GQLGTG 180
Score = 45.6 bits (103), Expect = 4e-04
Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 14/159 (8%)
Query: 308 DSMKRAFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGA 366
+S F WG +G+LG + K + P+L+K +G V GG +S + GA
Sbjct: 3 ESASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGA 60
Query: 367 LF-----MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVS 418
+F FGQ E + Y P + L I + G +T+ + + + +G
Sbjct: 61 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG 119
Query: 419 PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
YG+LG + P++V + +T++A G HT
Sbjct: 120 -GYGQLGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 156
Score = 31.1 bits (67), Expect = 8.9
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 412 LIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ WG + YG+LG+G K P+ + + + QVA G +H+ +L
Sbjct: 8 VFCWGQNK-YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 55
>AL133551-1|CAI16031.1| 907|Homo sapiens hect domain and RLD 4
protein.
Length = 907
Score = 85.8 bits (203), Expect = 3e-16
Identities = 61/216 (28%), Positives = 101/216 (46%), Gaps = 26/216 (12%)
Query: 126 LVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGC 184
+ E + +G+N GQLG G D ++ P+L+ L G + A G H+ +T +G
Sbjct: 1 MAESASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 60
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPE 244
++ G NK GQ GL + + + IV + CG + + L G + +FG
Sbjct: 61 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG 120
Query: 245 YGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHT 304
YGQLGHN+ TS +++ P+++ + G I + +++CG HT
Sbjct: 121 YGQLGHNS------TSHEIN------PRKVFELM-----GSI-------VTEIACGRQHT 156
Query: 305 VA-IDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIK 339
A + S R +S+G GG G+LG + P +K
Sbjct: 157 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 192
Score = 78.6 bits (185), Expect = 5e-14
Identities = 41/128 (32%), Positives = 67/128 (52%), Gaps = 1/128 (0%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS +++ G + +GRN GQLG D R VP L+ L+ + I++ G HT +T
Sbjct: 51 HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 110
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF-SMILDCNGNLHSFG 241
G V+ G GQ G +T+ +I + G+ + ++ CG + S + +G ++SFG
Sbjct: 111 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
Query: 242 MPEYGQLG 249
+ GQLG
Sbjct: 171 LGGNGQLG 178
Score = 76.2 bits (179), Expect = 2e-13
Identities = 58/189 (30%), Positives = 86/189 (45%), Gaps = 28/189 (14%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G NK GQ GLG + P +K G P ++V G S +L +G + +G
Sbjct: 8 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 67
Query: 244 EYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNH 303
++GQLG N + +V + S L QK IV + CG +H
Sbjct: 68 KFGQLGLNDENDRYVPNLLKS-----------LRSQK-------------IVYICCGEDH 103
Query: 304 TVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA-VN 362
T A+ F++G GG+G+LGH E PR K F+ +G V + CG ++ A V
Sbjct: 104 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPR--KVFELMGSIVTEIACGRQHTSAFVP 161
Query: 363 DQGALFMFG 371
G ++ FG
Sbjct: 162 SSGRIYSFG 170
Score = 64.1 bits (149), Expect = 1e-09
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHA 169
R +++ C H+ +++EG +TFG GQLG T P V EL G +
Sbjct: 90 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEI 149
Query: 170 AVGRHHT-LFVTDTGCVYACGDNKSGQCGLGNT----TPQILKPTRIKYNG 215
A GR HT FV +G +Y+ G +GQ G G+T +P +K YNG
Sbjct: 150 ACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 200
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/144 (23%), Positives = 68/144 (47%), Gaps = 11/144 (7%)
Query: 292 VTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSV 351
+ + ++ G H+ + F WG FG+LG ++ D VP L+K + + + +
Sbjct: 40 IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRS--QKIVYI 97
Query: 352 HCGGTYSLAVNDQGALFMF-----GQTKRTGEAN-MYPKPVHDLTGWNIKSV--GTSNTS 403
CG ++ A+ +G +F F GQ ++ + P+ V +L G + + G +TS
Sbjct: 98 CCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTS 157
Query: 404 IVIAADDSLIAWGVSPTYGELGMG 427
+ + + ++G+ G+LG G
Sbjct: 158 AFVPSSGRIYSFGLGGN-GQLGTG 180
Score = 45.6 bits (103), Expect = 4e-04
Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 14/159 (8%)
Query: 308 DSMKRAFSWGFGGFGRLG-HAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGA 366
+S F WG +G+LG + K + P+L+K +G V GG +S + GA
Sbjct: 3 ESASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGA 60
Query: 367 LF-----MFGQTKRTGEANMY-PKPVHDLTGWNIKSV--GTSNTSIVIAADDSLIAWGVS 418
+F FGQ E + Y P + L I + G +T+ + + + +G
Sbjct: 61 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTA-ALTKEGGVFTFGAG 119
Query: 419 PTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHT 457
YG+LG + P++V + +T++A G HT
Sbjct: 120 -GYGQLGHNSTSHE-INPRKVFELMGSIVTEIACGRQHT 156
Score = 31.1 bits (67), Expect = 8.9
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 412 LIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
+ WG + YG+LG+G K P+ + + + QVA G +H+ +L
Sbjct: 8 VFCWGQNK-YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 55
>BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis
gene a)- related kinase 8 protein.
Length = 692
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/265 (25%), Positives = 117/265 (44%), Gaps = 40/265 (15%)
Query: 112 YRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
Y ++ C A H + +S E E + +GR G+LG G + S P+ VP G+
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVC 502
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTT--------PQILKPTRIKYNGT------P 217
G ++ +T G ACG N+ + GL + + Q+ + G+ P
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
++ + G S + +G+ ++FG ++GQLG T+T+ P ++
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG---------TNTRRG---SRAPCKVQ-- 608
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRL 337
++ + + ++CG+ TVAI + +SWG G GRLG ++ D +PR
Sbjct: 609 ----------GLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRP 657
Query: 338 IKYFDTVGRGVRSVH-CGGTYSLAV 361
++ +T V SV C G LAV
Sbjct: 658 VQLDETHPYTVTSVSCCHGNTLLAV 682
Score = 71.7 bits (168), Expect = 5e-12
Identities = 59/258 (22%), Positives = 109/258 (42%), Gaps = 14/258 (5%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + +++ G TFG + G LG G S P +V L G ++ A G H L
Sbjct: 398 CGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLA 457
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLH 238
++ ++A G SG+ GLG G +V CG + SMIL G
Sbjct: 458 LSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQAL 517
Query: 239 SFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP-KQITLYIQKSKDGYITPVKDVTIVDL 297
+ G + +LG + LS E +P +Q+ + + G P+ ++ +
Sbjct: 518 ACGSNRFNKLGLD----------HLSLGEEPVPHQQVEEALSFTLLG-SAPLDQEPLLSI 566
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
G H+ A+ + +++G G+LG ++ P ++ + G + V CG +
Sbjct: 567 DLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE--GIKMAMVACGDAF 624
Query: 358 SLAVNDQGALFMFGQTKR 375
++A+ + ++ +G+ R
Sbjct: 625 TVAIGAESEVYSWGKGAR 642
Score = 56.8 bits (131), Expect = 2e-07
Identities = 74/317 (23%), Positives = 126/317 (39%), Gaps = 46/317 (14%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKV 221
G I H A G T +TD G + G +G G G+ T I +PT ++ G +V+V
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQV 448
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CGA + L L ++G + G+LG T + + P+Q+ +
Sbjct: 449 ACGASHVLALSTERELFAWGRGDSGRLGLGTRESH------------SCPQQVPM----- 491
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLG--HAEQKDENVPRL-- 337
P ++ V CG + ++ + +A + G F +LG H +E VP
Sbjct: 492 -----PPGQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQV 544
Query: 338 --IKYFDTVGRG------VRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYP 383
F +G + S+ G +S AV G + FG + T + P
Sbjct: 545 EEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAP 604
Query: 384 KPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRM 442
V L G + V + ++ I A+ + +WG G LG + + +P ++
Sbjct: 605 CKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG-KGARGRLGRRDEDAGLPRPVQLDET 663
Query: 443 DSLGITQVAMGYSHTLL 459
+T V+ + +TLL
Sbjct: 664 HPYTVTSVSCCHGNTLL 680
Score = 41.9 bits (94), Expect = 0.005
Identities = 41/187 (21%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYF- 341
P+ + +V ++ G + R W G GG L A ++ + P+ I F
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRFL 385
Query: 342 -DTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKR--TGEANM----YPKPVHDLTGWNI 394
G ++ V CG ++ + D+G + FG G ++ P V L G+ +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 395 KSVGTSNTSIV-IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
V + ++ ++ + L AWG + G LG+G +S + P++V +V G
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDS-GRLGLG-TRESHSCPQQVPMPPGQEAQRVVCG 503
Query: 454 YSHTLLL 460
+++L
Sbjct: 504 IDSSMIL 510
>BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8
protein.
Length = 692
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/265 (25%), Positives = 117/265 (44%), Gaps = 40/265 (15%)
Query: 112 YRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
Y ++ C A H + +S E E + +GR G+LG G + S P+ VP G+
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVC 502
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTT--------PQILKPTRIKYNGT------P 217
G ++ +T G ACG N+ + GL + + Q+ + G+ P
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
++ + G S + +G+ ++FG ++GQLG T+T+ P ++
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG---------TNTRRG---SRAPCKVQ-- 608
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRL 337
++ + + ++CG+ TVAI + +SWG G GRLG ++ D +PR
Sbjct: 609 ----------GLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRP 657
Query: 338 IKYFDTVGRGVRSVH-CGGTYSLAV 361
++ +T V SV C G LAV
Sbjct: 658 VQLDETHPYTVTSVSCCHGNTLLAV 682
Score = 71.7 bits (168), Expect = 5e-12
Identities = 59/258 (22%), Positives = 109/258 (42%), Gaps = 14/258 (5%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + +++ G TFG + G LG G S P +V L G ++ A G H L
Sbjct: 398 CGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLA 457
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLH 238
++ ++A G SG+ GLG G +V CG + SMIL G
Sbjct: 458 LSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQAL 517
Query: 239 SFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP-KQITLYIQKSKDGYITPVKDVTIVDL 297
+ G + +LG + LS E +P +Q+ + + G P+ ++ +
Sbjct: 518 ACGSNRFNKLGLD----------HLSLGEEPVPHQQVEEALSFTLLG-SAPLDQEPLLSI 566
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
G H+ A+ + +++G G+LG ++ P ++ + G + V CG +
Sbjct: 567 DLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE--GIKMAMVACGDAF 624
Query: 358 SLAVNDQGALFMFGQTKR 375
++A+ + ++ +G+ R
Sbjct: 625 TVAIGAESEVYSWGKGAR 642
Score = 56.8 bits (131), Expect = 2e-07
Identities = 74/317 (23%), Positives = 126/317 (39%), Gaps = 46/317 (14%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKV 221
G I H A G T +TD G + G +G G G+ T I +PT ++ G +V+V
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQV 448
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CGA + L L ++G + G+LG T + + P+Q+ +
Sbjct: 449 ACGASHVLALSTERELFAWGRGDSGRLGLGTRESH------------SCPQQVPM----- 491
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLG--HAEQKDENVPRL-- 337
P ++ V CG + ++ + +A + G F +LG H +E VP
Sbjct: 492 -----PPGQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQV 544
Query: 338 --IKYFDTVGRG------VRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYP 383
F +G + S+ G +S AV G + FG + T + P
Sbjct: 545 EEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAP 604
Query: 384 KPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRM 442
V L G + V + ++ I A+ + +WG G LG + + +P ++
Sbjct: 605 CKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG-KGARGRLGRRDEDAGLPRPVQLDET 663
Query: 443 DSLGITQVAMGYSHTLL 459
+T V+ + +TLL
Sbjct: 664 HPYTVTSVSCCHGNTLL 680
Score = 41.9 bits (94), Expect = 0.005
Identities = 41/187 (21%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYF- 341
P+ + +V ++ G + R W G GG L A ++ + P+ I F
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRFL 385
Query: 342 -DTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKR--TGEANM----YPKPVHDLTGWNI 394
G ++ V CG ++ + D+G + FG G ++ P V L G+ +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 395 KSVGTSNTSIV-IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
V + ++ ++ + L AWG + G LG+G +S + P++V +V G
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDS-GRLGLG-TRESHSCPQQVPMPPGQEAQRVVCG 503
Query: 454 YSHTLLL 460
+++L
Sbjct: 504 IDSSMIL 510
>BC065375-1|AAH65375.1| 458|Homo sapiens secretion regulating
guanine nucleotide exchange factor protein.
Length = 458
Score = 79.4 bits (187), Expect = 3e-14
Identities = 79/308 (25%), Positives = 129/308 (41%), Gaps = 43/308 (13%)
Query: 134 YTFGRNACGQLGFGDTVTRSVPELVPEL-KGKNIIHAAVGRHHTLFVTDTGCVYACGDNK 192
+ +G N+ GQLG G +P+ + + K +++ G H+ VTD G ++ CG NK
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNK 77
Query: 193 SGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHN 251
GQ GLG+T P + + G PI +V CG +F+++L NG + S G +GQLG
Sbjct: 78 DGQLGLGHTEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVP 136
Query: 252 TDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMK 311
+ V +P+ I L+ +K +V ++ G H VA +
Sbjct: 137 HGPRRCV-----------VPQAIELHKEK-------------VVCIAAGLRHAVAATASG 172
Query: 312 RAFSWGFGGFGRLGHAEQKDENVPRLIKYFD---TVGRGVRSVHC---GGTYSLAVNDQG 365
F WG G G + +P + G C G +S ++ D G
Sbjct: 173 IVFQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG 231
Query: 366 ALFMFGQTKR---TGEANMYPKP----VHDLTGWNIKSVGTSNTSIVIAAD-DSLIAWGV 417
++++G K EA P P H + ++ + T +V + + WG
Sbjct: 232 EVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWG- 290
Query: 418 SPTYGELG 425
YG+LG
Sbjct: 291 RADYGQLG 298
Score = 74.9 bits (176), Expect = 6e-13
Identities = 92/379 (24%), Positives = 155/379 (40%), Gaps = 54/379 (14%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNII 167
R R I G GHS +V++ G+ + G N GQLG G T +P P L G I
Sbjct: 49 RSVRRITGG--GGHSAVVTDGGDLFVCGLNKDGQLGLGH--TEDIPYFTPCKSLFGCPIQ 104
Query: 168 HAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
A G T+ +T+ G V +CG N GQ G+ + + + P I+ + +V + G
Sbjct: 105 QVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRH 164
Query: 228 SMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYIT 287
++ +G + +G G + G+ +T+P L+ + +T
Sbjct: 165 AVAATASGIVFQWG------TGLASCGRRLCPG-------QTLP----LFFTAKEPSRVT 207
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+++ + + G++H+ ++ + WG G+L + E VP+ I+
Sbjct: 208 GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEK 266
Query: 348 VRSVHCGGTYSLAVNDQGALFM-----FGQTKRTGEA-------------------NMYP 383
V ++ G T+ +A + G +F +GQ R E N P
Sbjct: 267 VTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMP 326
Query: 384 KPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMG-EINKSTAKPKEVSRM 442
H LTG S G+ + +I +WG + +G G G E N KP + + +
Sbjct: 327 SSPHCLTGATEVSCGSEHNLAIIGG--VCYSWGWN-EHGMCGDGTEANVWAPKPVQ-ALL 382
Query: 443 DSLGITQVAMGYSHTLLLC 461
S G+ V G H+L LC
Sbjct: 383 SSSGLL-VGCGAGHSLALC 400
Score = 47.6 bits (108), Expect = 1e-04
Identities = 40/152 (26%), Positives = 72/152 (47%), Gaps = 10/152 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
F+WG +G+LG ++D +P+ + F R VR + GG +S V D G LF+ G
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 374 K--RTG----EANMYPKPVHDLTGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM 426
K + G E Y P L G I+ V + +I++ + +++ G S ++G+LG+
Sbjct: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG-SNSFGQLGV 135
Query: 427 GEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+ P+ + + + +A G H +
Sbjct: 136 PHGPRRCVVPQAI-ELHKEKVVCIAAGLRHAV 166
>AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8
protein.
Length = 692
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/265 (25%), Positives = 117/265 (44%), Gaps = 40/265 (15%)
Query: 112 YRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
Y ++ C A H + +S E E + +GR G+LG G + S P+ VP G+
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVC 502
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTT--------PQILKPTRIKYNGT------P 217
G ++ +T G ACG N+ + GL + + Q+ + G+ P
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
++ + G S + +G+ ++FG ++GQLG T+T+ P ++
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG---------TNTRRG---SRAPCKVQ-- 608
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRL 337
++ + + ++CG+ TVAI + +SWG G GRLG ++ D +PR
Sbjct: 609 ----------GLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRP 657
Query: 338 IKYFDTVGRGVRSVH-CGGTYSLAV 361
++ +T V SV C G LAV
Sbjct: 658 VQLDETHPYTVTSVSCCHGNTLLAV 682
Score = 71.7 bits (168), Expect = 5e-12
Identities = 59/258 (22%), Positives = 109/258 (42%), Gaps = 14/258 (5%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + +++ G TFG + G LG G S P +V L G ++ A G H L
Sbjct: 398 CGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLA 457
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLH 238
++ ++A G SG+ GLG G +V CG + SMIL G
Sbjct: 458 LSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQAL 517
Query: 239 SFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP-KQITLYIQKSKDGYITPVKDVTIVDL 297
+ G + +LG + LS E +P +Q+ + + G P+ ++ +
Sbjct: 518 ACGSNRFNKLGLD----------HLSLGEEPVPHQQVEEALSFTLLG-SAPLDQEPLLSI 566
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
G H+ A+ + +++G G+LG ++ P ++ + G + V CG +
Sbjct: 567 DLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE--GIKMAMVACGDAF 624
Query: 358 SLAVNDQGALFMFGQTKR 375
++A+ + ++ +G+ R
Sbjct: 625 TVAIGAESEVYSWGKGAR 642
Score = 56.8 bits (131), Expect = 2e-07
Identities = 74/317 (23%), Positives = 126/317 (39%), Gaps = 46/317 (14%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKV 221
G I H A G T +TD G + G +G G G+ T I +PT ++ G +V+V
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQV 448
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CGA + L L ++G + G+LG T + + P+Q+ +
Sbjct: 449 ACGASHVLALSTERELFAWGRGDSGRLGLGTRESH------------SCPQQVPM----- 491
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLG--HAEQKDENVPRL-- 337
P ++ V CG + ++ + +A + G F +LG H +E VP
Sbjct: 492 -----PPGQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQV 544
Query: 338 --IKYFDTVGRG------VRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYP 383
F +G + S+ G +S AV G + FG + T + P
Sbjct: 545 EEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAP 604
Query: 384 KPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRM 442
V L G + V + ++ I A+ + +WG G LG + + +P ++
Sbjct: 605 CKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG-KGARGRLGRRDEDAGLPRPVQLDET 663
Query: 443 DSLGITQVAMGYSHTLL 459
+T V+ + +TLL
Sbjct: 664 HPYTVTSVSCCHGNTLL 680
Score = 41.9 bits (94), Expect = 0.005
Identities = 41/187 (21%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYF- 341
P+ + +V ++ G + R W G GG L A ++ + P+ I F
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRFL 385
Query: 342 -DTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKR--TGEANM----YPKPVHDLTGWNI 394
G ++ V CG ++ + D+G + FG G ++ P V L G+ +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 395 KSVGTSNTSIV-IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
V + ++ ++ + L AWG + G LG+G +S + P++V +V G
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDS-GRLGLG-TRESHSCPQQVPMPPGQEAQRVVCG 503
Query: 454 YSHTLLL 460
+++L
Sbjct: 504 IDSSMIL 510
>AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a
protein.
Length = 692
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/265 (25%), Positives = 117/265 (44%), Gaps = 40/265 (15%)
Query: 112 YRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
Y ++ C A H + +S E E + +GR G+LG G + S P+ VP G+
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVC 502
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTT--------PQILKPTRIKYNGT------P 217
G ++ +T G ACG N+ + GL + + Q+ + G+ P
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 218 IVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLY 277
++ + G S + +G+ ++FG ++GQLG T+T+ P ++
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG---------TNTRRG---SRAPCKVQ-- 608
Query: 278 IQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRL 337
++ + + ++CG+ TVAI + +SWG G GRLG ++ D +PR
Sbjct: 609 ----------GLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRP 657
Query: 338 IKYFDTVGRGVRSVH-CGGTYSLAV 361
++ +T V SV C G LAV
Sbjct: 658 VQLDETHPYTVTSVSCCHGNTLLAV 682
Score = 71.7 bits (168), Expect = 5e-12
Identities = 59/258 (22%), Positives = 109/258 (42%), Gaps = 14/258 (5%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C + +++ G TFG + G LG G S P +V L G ++ A G H L
Sbjct: 398 CGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLA 457
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLH 238
++ ++A G SG+ GLG G +V CG + SMIL G
Sbjct: 458 LSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQAL 517
Query: 239 SFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIP-KQITLYIQKSKDGYITPVKDVTIVDL 297
+ G + +LG + LS E +P +Q+ + + G P+ ++ +
Sbjct: 518 ACGSNRFNKLGLD----------HLSLGEEPVPHQQVEEALSFTLLG-SAPLDQEPLLSI 566
Query: 298 SCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTY 357
G H+ A+ + +++G G+LG ++ P ++ + G + V CG +
Sbjct: 567 DLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE--GIKMAMVACGDAF 624
Query: 358 SLAVNDQGALFMFGQTKR 375
++A+ + ++ +G+ R
Sbjct: 625 TVAIGAESEVYSWGKGAR 642
Score = 56.8 bits (131), Expect = 2e-07
Identities = 74/317 (23%), Positives = 126/317 (39%), Gaps = 46/317 (14%)
Query: 163 GKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKV 221
G I H A G T +TD G + G +G G G+ T I +PT ++ G +V+V
Sbjct: 390 GVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQV 448
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CGA + L L ++G + G+LG T + + P+Q+ +
Sbjct: 449 ACGASHVLALSTERELFAWGRGDSGRLGLGTRESH------------SCPQQVPM----- 491
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLG--HAEQKDENVPRL-- 337
P ++ V CG + ++ + +A + G F +LG H +E VP
Sbjct: 492 -----PPGQEAQRV--VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQV 544
Query: 338 --IKYFDTVGRG------VRSVHCGGTYSLAVNDQGALFMFGQTK------RTGEANMYP 383
F +G + S+ G +S AV G + FG + T + P
Sbjct: 545 EEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAP 604
Query: 384 KPVHDLTGWNIKSVGTSNT-SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRM 442
V L G + V + ++ I A+ + +WG G LG + + +P ++
Sbjct: 605 CKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG-KGARGRLGRRDEDAGLPRPVQLDET 663
Query: 443 DSLGITQVAMGYSHTLL 459
+T V+ + +TLL
Sbjct: 664 HPYTVTSVSCCHGNTLL 680
Score = 41.9 bits (94), Expect = 0.005
Identities = 41/187 (21%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSW-----GFGGFGRLGHAEQKDENVPRLIKYF- 341
P+ + +V ++ G + R W G GG L A ++ + P+ I F
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRFL 385
Query: 342 -DTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKR--TGEANM----YPKPVHDLTGWNI 394
G ++ V CG ++ + D+G + FG G ++ P V L G+ +
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 395 KSVGTSNTSIV-IAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMG 453
V + ++ ++ + L AWG + G LG+G +S + P++V +V G
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDS-GRLGLG-TRESHSCPQQVPMPPGQEAQRVVCG 503
Query: 454 YSHTLLL 460
+++L
Sbjct: 504 IDSSMIL 510
>AJ243950-1|CAB60832.1| 458|Homo sapiens deafness locus associated
putative guanine nucleotide exchange factor protein.
Length = 458
Score = 79.4 bits (187), Expect = 3e-14
Identities = 79/308 (25%), Positives = 129/308 (41%), Gaps = 43/308 (13%)
Query: 134 YTFGRNACGQLGFGDTVTRSVPELVPEL-KGKNIIHAAVGRHHTLFVTDTGCVYACGDNK 192
+ +G N+ GQLG G +P+ + + K +++ G H+ VTD G ++ CG NK
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNK 77
Query: 193 SGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHN 251
GQ GLG+T P + + G PI +V CG +F+++L NG + S G +GQLG
Sbjct: 78 DGQLGLGHTEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVP 136
Query: 252 TDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMK 311
+ V +P+ I L+ +K +V ++ G H VA +
Sbjct: 137 HGPRRCV-----------VPQAIELHKEK-------------VVCIAAGLRHAVAATASG 172
Query: 312 RAFSWGFGGFGRLGHAEQKDENVPRLIKYFD---TVGRGVRSVHC---GGTYSLAVNDQG 365
F WG G G + +P + G C G +S ++ D G
Sbjct: 173 IVFQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG 231
Query: 366 ALFMFGQTKR---TGEANMYPKP----VHDLTGWNIKSVGTSNTSIVIAAD-DSLIAWGV 417
++++G K EA P P H + ++ + T +V + + WG
Sbjct: 232 EVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWG- 290
Query: 418 SPTYGELG 425
YG+LG
Sbjct: 291 RADYGQLG 298
Score = 74.9 bits (176), Expect = 6e-13
Identities = 92/379 (24%), Positives = 155/379 (40%), Gaps = 54/379 (14%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNII 167
R R I G GHS +V++ G+ + G N GQLG G T +P P L G I
Sbjct: 49 RSVRRITGG--GGHSAVVTDGGDLFVCGLNKDGQLGLGH--TEDIPYFTPCKSLFGCPIQ 104
Query: 168 HAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
A G T+ +T+ G V +CG N GQ G+ + + + P I+ + +V + G
Sbjct: 105 QVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRH 164
Query: 228 SMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYIT 287
++ +G + +G G + G+ +T+P L+ + +T
Sbjct: 165 AVAATASGIVFQWG------TGLASCGRRLCPG-------QTLP----LFFTAKEPSRVT 207
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+++ + + G++H+ ++ + WG G+L + E VP+ I+
Sbjct: 208 GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEK 266
Query: 348 VRSVHCGGTYSLAVNDQGALFM-----FGQTKRTGEA-------------------NMYP 383
V ++ G T+ +A + G +F +GQ R E N P
Sbjct: 267 VTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMP 326
Query: 384 KPVHDLTGWNIKSVGTSNTSIVIAADDSLIAWGVSPTYGELGMG-EINKSTAKPKEVSRM 442
H LTG S G+ + +I +WG + +G G G E N KP + + +
Sbjct: 327 SSPHCLTGATEVSCGSEHNLAIIGG--VCYSWGWN-EHGMCGDGTEANVWAPKPVQ-ALL 382
Query: 443 DSLGITQVAMGYSHTLLLC 461
S G+ V G H+L LC
Sbjct: 383 SSSGLL-VGCGAGHSLALC 400
Score = 47.6 bits (108), Expect = 1e-04
Identities = 40/152 (26%), Positives = 72/152 (47%), Gaps = 10/152 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
F+WG +G+LG ++D +P+ + F R VR + GG +S V D G LF+ G
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 374 K--RTG----EANMYPKPVHDLTGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM 426
K + G E Y P L G I+ V + +I++ + +++ G S ++G+LG+
Sbjct: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG-SNSFGQLGV 135
Query: 427 GEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+ P+ + + + +A G H +
Sbjct: 136 PHGPRRCVVPQAI-ELHKEKVVCIAAGLRHAV 166
>AJ243951-1|CAB60833.1| 288|Homo sapiens deafness locus associated
putative guanine nucleotide exchange factor protein.
Length = 288
Score = 75.4 bits (177), Expect = 4e-13
Identities = 45/139 (32%), Positives = 71/139 (51%), Gaps = 3/139 (2%)
Query: 134 YTFGRNACGQLGFGDTVTRSVPELVPEL-KGKNIIHAAVGRHHTLFVTDTGCVYACGDNK 192
+ +G N+ GQLG G +P+ + + K +++ G H+ VTD G ++ CG NK
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNK 77
Query: 193 SGQCGLGNTTP-QILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHN 251
GQ GLG+T P + + G PI +V CG +F+++L NG + S G +GQLG
Sbjct: 78 DGQLGLGHTEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVP 136
Query: 252 TDGKYFVTSTKLSFHFETI 270
+ V + H E +
Sbjct: 137 HGPRRCVVPQAIELHKEKV 155
Score = 66.1 bits (154), Expect = 3e-10
Identities = 60/253 (23%), Positives = 109/253 (43%), Gaps = 24/253 (9%)
Query: 110 RRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNII 167
R R I G GHS +V++ G+ + G N GQLG G T +P P L G I
Sbjct: 49 RSVRRITGG--GGHSAVVTDGGDLFVCGLNKDGQLGLGH--TEDIPYFTPCKSLFGCPIQ 104
Query: 168 HAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
A G T+ +T+ G V +CG N GQ G+ + + + P I+ + +V + G
Sbjct: 105 QVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRH 164
Query: 228 SMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYIT 287
++ +G + +G G + G+ +T+P L+ + +T
Sbjct: 165 AVAATASGIVFQWG------TGLASCGRRLCPG-------QTLP----LFFTAKEPSRVT 207
Query: 288 PVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRG 347
+++ + + G++H+ ++ + WG G+L + E VP+ I+
Sbjct: 208 GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEK 266
Query: 348 VRSVHCGGTYSLA 360
V ++ G T+ +A
Sbjct: 267 VTAIWSGWTHLVA 279
Score = 47.6 bits (108), Expect = 1e-04
Identities = 40/152 (26%), Positives = 72/152 (47%), Gaps = 10/152 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
F+WG +G+LG ++D +P+ + F R VR + GG +S V D G LF+ G
Sbjct: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 374 K--RTG----EANMYPKPVHDLTGWNIKSVGTS-NTSIVIAADDSLIAWGVSPTYGELGM 426
K + G E Y P L G I+ V + +I++ + +++ G S ++G+LG+
Sbjct: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG-SNSFGQLGV 135
Query: 427 GEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
+ P+ + + + +A G H +
Sbjct: 136 PHGPRRCVVPQAI-ELHKEKVVCIAAGLRHAV 166
>AC004460-2|AAC06339.1| 371|Homo sapiens WUGSC:H_DJ1086D14.2
protein.
Length = 371
Score = 74.5 bits (175), Expect = 7e-13
Identities = 43/112 (38%), Positives = 61/112 (54%), Gaps = 2/112 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C A + +++ G +T+G+ +LG V P++V L+GK I+H AVG H L
Sbjct: 41 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 100
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSM 229
V D+G VYA GDN GQ G G TT KP ++ G I+ V CG+ S+
Sbjct: 101 VMDSGQVYAWGDNDHGQQGNGTTTVN-RKPMLVQGLEGQKIMCVACGSSHSV 151
Score = 58.8 bits (136), Expect = 4e-08
Identities = 45/152 (29%), Positives = 70/152 (46%), Gaps = 11/152 (7%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
FSWG G FG+LG + N+P+ I+ + G+GV + CG + LA+ G ++ +G+
Sbjct: 4 FSWGDGDFGKLGRGGSEGCNIPQNIERLN--GQGVCQIECGAQFLLALTKSGVVWTWGKG 61
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + P+ V L G I V + D + AWG +G+ G
Sbjct: 62 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWG-DNDHGQQGN 120
Query: 427 GEINKSTAKPKEVSRMDSLGITQVAMGYSHTL 458
G + KP V ++ I VA G SH++
Sbjct: 121 GTTTVN-RKPMLVQGLEGQKIMCVACGSSHSV 151
Score = 53.6 bits (123), Expect = 1e-06
Identities = 39/178 (21%), Positives = 82/178 (46%), Gaps = 26/178 (14%)
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGM 242
G V++ GD G+ G G + + + NG + ++ CGA+F + L +G + ++G
Sbjct: 1 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 60
Query: 243 PEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNN 302
+Y +LGH +D ++++K + + ++ IV ++ G
Sbjct: 61 GDYFRLGHRSD----------------------VHVRKPQ--VVEGLRGKKIVHVAVGAQ 96
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA 360
H +A+ + ++WG G+ G+ P L++ + G+ + V CG ++S+A
Sbjct: 97 HCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLE--GQKIMCVACGSSHSVA 152
Score = 49.6 bits (113), Expect = 2e-05
Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 4/124 (3%)
Query: 131 GEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGD 190
G +++G G+LG G + ++P+ + L G+ + G L +T +G V+ G
Sbjct: 1 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG- 59
Query: 191 NKSGQCGLGNTTP-QILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQL 248
K LG+ + + KP ++ G IV V GA+ + + +G ++++G ++GQ
Sbjct: 60 -KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 118
Query: 249 GHNT 252
G+ T
Sbjct: 119 GNGT 122
Score = 42.3 bits (95), Expect = 0.004
Identities = 30/118 (25%), Positives = 49/118 (41%), Gaps = 8/118 (6%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
+ + CG +A+ ++WG G + RLGH P++++ G+ + V
Sbjct: 36 VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE--GLRGKKIVHVAV 93
Query: 354 GGTYSLAVNDQGALFMFG------QTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIV 405
G + LAV D G ++ +G Q T N P V L G I V ++ V
Sbjct: 94 GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 151
>DQ005634-1|AAY55907.1| 1196|Homo sapiens inhibitor of Bruton's
tyrosine kinase-beta protein.
Length = 1196
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 248 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 306
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 307 MGL-NGGQLG 315
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 203 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 145 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 263
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 245
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 246 EDGCVYTFG 254
>DQ005633-1|AAY55906.1| 1353|Homo sapiens inhibitor of Bruton's
tyrosine kinase-alpha protein.
Length = 1353
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 248 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 306
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 307 MGL-NGGQLG 315
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 203 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 145 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 263
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 245
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 246 EDGCVYTFG 254
>BC113698-1|AAI13699.1| 1353|Homo sapiens inhibitor of Bruton
agammaglobulinemia tyrosine kinase protein.
Length = 1353
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 248 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 306
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 307 MGL-NGGQLG 315
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 203 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 145 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 263
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 245
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 246 EDGCVYTFG 254
>BC113696-1|AAI13697.1| 1353|Homo sapiens inhibitor of Bruton
agammaglobulinemia tyrosine kinase protein.
Length = 1353
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 248 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 306
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 307 MGL-NGGQLG 315
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 203 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 145 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 263
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 245
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 246 EDGCVYTFG 254
>AL050333-2|CAI23416.1| 1187|Homo sapiens RP1-93K22.1 protein.
Length = 1187
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 184 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 243
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 244 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 302
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 303 MGL-NGGQLG 311
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 139 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 198
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 199 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 258
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 141 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 200
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 201 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 259
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 260 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 294
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 184 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 241
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 242 EDGCVYTFG 250
>AB037838-1|BAA92655.2| 1379|Homo sapiens KIAA1417 protein protein.
Length = 1379
Score = 73.3 bits (172), Expect = 2e-12
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HSV +S++G+ YT G G+LG GD T VP LV L G N A + HT+ +T+
Sbjct: 214 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 273
Query: 183 GCVYACGDNKSGQCGLGNTTPQILKPTRI--KY-NGTPIVKVGCGAEFSMILDCNGNLHS 239
GCVY G N Q G+ P +I KY G I+ V G F +L +++
Sbjct: 274 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG-RFHTVLWTREAVYT 332
Query: 240 FGMPEYGQLG 249
G+ GQLG
Sbjct: 333 MGL-NGGQLG 341
Score = 54.0 bits (124), Expect = 1e-06
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Query: 132 EAYTFGRNACGQLGFGDTVTRSVPELVP--ELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
+ YT+G N LG G ++ PELV G I + + H++F++ G VY CG
Sbjct: 169 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 228
Query: 190 DNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G+ G G+ ++ NG +V + +++L +G +++FG+ + QLG
Sbjct: 229 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 288
Score = 43.6 bits (98), Expect = 0.002
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQT 373
++WG LGH Q ++ P L+ F G ++ V +S+ ++ +G ++ G
Sbjct: 171 YTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 230
Query: 374 K--RTGEAN----MYPKPVHDLTGWNIKSVGTSNTSIVIAADDSLI-AWGVSPTYGELGM 426
R G + + P+ V L G N V + V+ +D + +G++ + +LG+
Sbjct: 231 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN-IFHQLGI 289
Query: 427 GEINKSTAKPKEVSRMDSLG--ITQVAMGYSHTLL 459
S P+++ G I VA G HT+L
Sbjct: 290 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 324
Score = 38.3 bits (85), Expect = 0.059
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 303 HTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVN 362
H+V + + ++ G G GRLGH +++ VPRL++ + G V +++ +
Sbjct: 214 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN--GHNCSQVAAAKDHTVVLT 271
Query: 363 DQGALFMFG 371
+ G ++ FG
Sbjct: 272 EDGCVYTFG 280
>AK092403-1|BAC03879.1| 184|Homo sapiens protein ( Homo sapiens
cDNA FLJ35084 fis, clone PLACE6005482. ).
Length = 184
Score = 70.1 bits (164), Expect = 2e-11
Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 4/143 (2%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFG-DTVTRSVPELVPELKGKNIIHAAV 171
++I C HS+ +S++ + +++G+N+ GQLG G + +++ P+ V L+G + A
Sbjct: 7 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA 66
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGL-GNTTP-QILKPTRI-KYNGTPIVKVGCGAEFS 228
G H+ ++ G + G N +GQ L G P Q KP + +V + CG +
Sbjct: 67 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 126
Query: 229 MILDCNGNLHSFGMPEYGQLGHN 251
+L +G + +FG GQLG++
Sbjct: 127 AVLTQDGKVFTFGDNRSGQLGYS 149
Score = 69.7 bits (163), Expect = 2e-11
Identities = 51/190 (26%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 166 IIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCG 224
II + G +H+L ++ V++ G N GQ GLG P P R++ G P+ +V G
Sbjct: 8 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG 67
Query: 225 AEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDG 284
S L G SFG G N+ G+ L+ +P +Q +K
Sbjct: 68 GAHSFALSLCGT--SFGW------GSNSAGQ-------LALSGRNVP------VQSNKPL 106
Query: 285 YITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTV 344
+ +K++ +V +SCG+ HT + + F++G G+LG++ ++ P+L++ D +
Sbjct: 107 SVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL 166
Query: 345 GRGVRSVHCG 354
V + CG
Sbjct: 167 ---VSQIDCG 173
Score = 53.2 bits (122), Expect = 2e-06
Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 4/105 (3%)
Query: 123 HSVLVSEEGEAYTFGRNACGQL---GFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFV 179
HS +S G ++ +G N+ GQL G V + P V LK +++ + G HT +
Sbjct: 70 HSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVL 129
Query: 180 TDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCG 224
T G V+ GDN+SGQ G + TP+ P ++ + ++ CG
Sbjct: 130 TQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDGLVSQIDCG 173
Score = 50.0 bits (114), Expect = 2e-05
Identities = 45/175 (25%), Positives = 84/175 (48%), Gaps = 14/175 (8%)
Query: 289 VKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQ-KDENVPRLIKYFDTVGRG 347
+ D+ I+ +SCG+ H++A+ + FSWG G+LG ++ + P+ ++ + G
Sbjct: 3 LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLE--GIP 60
Query: 348 VRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPK--PVHD---LTGWNIKSVGTSNT 402
+ V GG +S A++ G F +G + G+ + + PV L+ +K++G
Sbjct: 61 LAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYI 119
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINKSTAK----PKEVSRMDSLGITQVAMG 453
S A L G T+G+ G++ S P+ V R+D L ++Q+ G
Sbjct: 120 SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCG 173
Score = 45.2 bits (102), Expect = 5e-04
Identities = 43/175 (24%), Positives = 70/175 (40%), Gaps = 29/175 (16%)
Query: 214 NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQ 273
N I++V CG S+ L + + S+G +GQLG GK F P Q
Sbjct: 4 NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL---GKEF-------------PSQ 47
Query: 274 ITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRL---GHAEQK 330
+ +S +G + + ++ G H+ A+ +F WG G+L G
Sbjct: 48 ASPQRVRSLEG-------IPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPV 100
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKP 385
N P + + GV + CG ++ + G +F FG R+G+ P P
Sbjct: 101 QSNKPLSVGALKNL--GVVYISCGDAHTAVLTQDGKVFTFGD-NRSGQLGYSPTP 152
Score = 43.2 bits (97), Expect = 0.002
Identities = 16/50 (32%), Positives = 30/50 (60%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKG 163
++ C H+ +++++G+ +TFG N GQLG+ T + P+LV + G
Sbjct: 116 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDG 165
Score = 42.3 bits (95), Expect = 0.004
Identities = 18/58 (31%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLL 460
S+ ++ D + +WG + ++G+LG+G+ S A P+ V ++ + + QVA G +H+ L
Sbjct: 18 SLALSKDSQVFSWGKN-SHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 74
Score = 36.3 bits (80), Expect = 0.24
Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 11/120 (9%)
Query: 351 VHCGGTYSLAVNDQGALFMFGQTKR----TGE---ANMYPKPVHDLTGWNIKSVGTSNT- 402
V CG +SLA++ +F +G+ G+ + P+ V L G + V
Sbjct: 11 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 70
Query: 403 SIVIAADDSLIAWGVSPTYGELGMGEINK--STAKPKEVSRMDSLGITQVAMGYSHTLLL 460
S ++ + WG S + G+L + N + KP V + +LG+ ++ G +HT +L
Sbjct: 71 SFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVL 129
>BC032712-1|AAH32712.1| 454|Homo sapiens WBSCR16 protein protein.
Length = 454
Score = 68.1 bits (159), Expect = 6e-11
Identities = 61/273 (22%), Positives = 115/273 (42%), Gaps = 34/273 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG--FGDTVTRSVPELVPELKGKN--IIH 168
R++ C HS+++++ ++ G N+ GQ G + S V ++ + ++
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI--KYNGTPIVKVGCGAE 226
A G+ H+LF+TD G VY+CG GQ GLG+ PT++ G +++V +
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 227 FSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYI 286
+ + +G L +G EY QL TD + HF + K
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQ--VNVPRCLHFSGVGK-------------- 337
Query: 287 TPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK--DENVPRLIKYFDTV 344
+ +CG ++ F WG+G G+ + + E +P +
Sbjct: 338 -------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEF 390
Query: 345 GRGVR--SVHCGGTYSLAVNDQGALFMFGQTKR 375
++ + CG ++ A+ ++G LF++G+ R
Sbjct: 391 NPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
Score = 64.5 bits (150), Expect = 8e-10
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 105 HKFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGD-TVTRSVPELVPELKG 163
H+ D +++ C HS+ ++++GE Y+ G A GQ G G +T S +L +L G
Sbjct: 223 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
Query: 164 KNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VG 222
N+I A L V+ G ++ G+++ Q + Q+ P + ++G V+
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
Query: 223 CGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSK 282
CG +L+ G++ +G YG LG G V S E IP TL+
Sbjct: 343 CGGTGCAVLNGEGHVFVWG---YGILG---KGPNLVESAVP----EMIPP--TLF----- 385
Query: 283 DGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVP 335
G ++ + + CG +H A+ + F WG G LG +D+ P
Sbjct: 386 -GLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Score = 42.7 bits (96), Expect = 0.003
Identities = 66/299 (22%), Positives = 111/299 (37%), Gaps = 48/299 (16%)
Query: 164 KNIIHAAVGRHHTLF---VTDTGCVYACGDNKSGQCGLGNTTPQ-------ILKPTRIKY 213
+ I AA G TL D V+ G NK Q G + +L+P+ +
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSL 166
Query: 214 -----NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFE 268
T +++V CG S++L + S G YGQ G E
Sbjct: 167 PLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKV------------VENE 214
Query: 269 TIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAE 328
+ ++ + DG + V ++CG +H++ + +S G+G G+ G
Sbjct: 215 IYSESHRVHRMQDFDGQV--------VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266
Query: 329 QKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANM------- 381
+ P + D G V V G LAV+ G LF +G ++ A++
Sbjct: 267 YNITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
Query: 382 YPKPVHDLTGWNIKSVGTSNTS-IVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEV 439
P+ +H ++ T V+ + + WG YG LG G +A P+ +
Sbjct: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMI 380
>BC019008-1|AAH19008.1| 464|Homo sapiens Williams-Beuren syndrome
chromosome region 16 protein.
Length = 464
Score = 68.1 bits (159), Expect = 6e-11
Identities = 61/273 (22%), Positives = 115/273 (42%), Gaps = 34/273 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG--FGDTVTRSVPELVPELKGKN--IIH 168
R++ C HS+++++ ++ G N+ GQ G + S V ++ + ++
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI--KYNGTPIVKVGCGAE 226
A G+ H+LF+TD G VY+CG GQ GLG+ PT++ G +++V +
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 227 FSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYI 286
+ + +G L +G EY QL TD + HF + K
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQ--VNVPRCLHFSGVGK-------------- 337
Query: 287 TPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK--DENVPRLIKYFDTV 344
+ +CG ++ F WG+G G+ + + E +P +
Sbjct: 338 -------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEF 390
Query: 345 GRGVR--SVHCGGTYSLAVNDQGALFMFGQTKR 375
++ + CG ++ A+ ++G LF++G+ R
Sbjct: 391 NPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
Score = 64.5 bits (150), Expect = 8e-10
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 105 HKFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGD-TVTRSVPELVPELKG 163
H+ D +++ C HS+ ++++GE Y+ G A GQ G G +T S +L +L G
Sbjct: 223 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
Query: 164 KNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VG 222
N+I A L V+ G ++ G+++ Q + Q+ P + ++G V+
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
Query: 223 CGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSK 282
CG +L+ G++ +G YG LG G V S E IP TL+
Sbjct: 343 CGGTGCAVLNGEGHVFVWG---YGILG---KGPNLVESAVP----EMIPP--TLF----- 385
Query: 283 DGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVP 335
G ++ + + CG +H A+ + F WG G LG +D+ P
Sbjct: 386 -GLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Score = 42.7 bits (96), Expect = 0.003
Identities = 66/299 (22%), Positives = 111/299 (37%), Gaps = 48/299 (16%)
Query: 164 KNIIHAAVGRHHTLF---VTDTGCVYACGDNKSGQCGLGNTTPQ-------ILKPTRIKY 213
+ I AA G TL D V+ G NK Q G + +L+P+ +
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSL 166
Query: 214 -----NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFE 268
T +++V CG S++L + S G YGQ G E
Sbjct: 167 PLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKV------------VENE 214
Query: 269 TIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAE 328
+ ++ + DG + V ++CG +H++ + +S G+G G+ G
Sbjct: 215 IYSESHRVHRMQDFDGQV--------VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266
Query: 329 QKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANM------- 381
+ P + D G V V G LAV+ G LF +G ++ A++
Sbjct: 267 YNITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
Query: 382 YPKPVHDLTGWNIKSVGTSNTS-IVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEV 439
P+ +H ++ T V+ + + WG YG LG G +A P+ +
Sbjct: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMI 380
Score = 35.9 bits (79), Expect = 0.31
Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 14/124 (11%)
Query: 117 SGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPE-LKGKNIIHAAV--- 171
+ C +++ EG + +G G LG G + S VPE++P L G + +
Sbjct: 341 AACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
Query: 172 ----GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
G H +T+ G ++ G N G G+G Q P R+ G P V V CG +
Sbjct: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRVTMPGEP-VDVACGVDH 455
Query: 228 SMIL 231
+ L
Sbjct: 456 MVTL 459
>BC007823-1|AAH07823.1| 464|Homo sapiens Williams-Beuren syndrome
chromosome region 16 protein.
Length = 464
Score = 68.1 bits (159), Expect = 6e-11
Identities = 61/273 (22%), Positives = 115/273 (42%), Gaps = 34/273 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG--FGDTVTRSVPELVPELKGKN--IIH 168
R++ C HS+++++ ++ G N+ GQ G + S V ++ + ++
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI--KYNGTPIVKVGCGAE 226
A G+ H+LF+TD G VY+CG GQ GLG+ PT++ G +++V +
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 227 FSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYI 286
+ + +G L +G EY QL TD + HF + K
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQ--VNVPRCLHFSGVGK-------------- 337
Query: 287 TPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK--DENVPRLIKYFDTV 344
+ +CG ++ F WG+G G+ + + E +P +
Sbjct: 338 -------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEF 390
Query: 345 GRGVR--SVHCGGTYSLAVNDQGALFMFGQTKR 375
++ + CG ++ A+ ++G LF++G+ R
Sbjct: 391 NPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
Score = 64.5 bits (150), Expect = 8e-10
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 105 HKFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGD-TVTRSVPELVPELKG 163
H+ D +++ C HS+ ++++GE Y+ G A GQ G G +T S +L +L G
Sbjct: 223 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
Query: 164 KNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VG 222
N+I A L V+ G ++ G+++ Q + Q+ P + ++G V+
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
Query: 223 CGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSK 282
CG +L+ G++ +G YG LG G V S E IP TL+
Sbjct: 343 CGGTGCAVLNGEGHVFVWG---YGILG---KGPNLVESAVP----EMIPP--TLF----- 385
Query: 283 DGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVP 335
G ++ + + CG +H A+ + F WG G LG +D+ P
Sbjct: 386 -GLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Score = 42.7 bits (96), Expect = 0.003
Identities = 66/299 (22%), Positives = 111/299 (37%), Gaps = 48/299 (16%)
Query: 164 KNIIHAAVGRHHTLF---VTDTGCVYACGDNKSGQCGLGNTTPQ-------ILKPTRIKY 213
+ I AA G TL D V+ G NK Q G + +L+P+ +
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSL 166
Query: 214 -----NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFE 268
T +++V CG S++L + S G YGQ G E
Sbjct: 167 PLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKV------------VENE 214
Query: 269 TIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAE 328
+ ++ + DG + V ++CG +H++ + +S G+G G+ G
Sbjct: 215 IYSESHRVHRMQDFDGQV--------VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266
Query: 329 QKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANM------- 381
+ P + D G V V G LAV+ G LF +G ++ A++
Sbjct: 267 YNITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
Query: 382 YPKPVHDLTGWNIKSVGTSNTS-IVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEV 439
P+ +H ++ T V+ + + WG YG LG G +A P+ +
Sbjct: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMI 380
Score = 35.9 bits (79), Expect = 0.31
Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 14/124 (11%)
Query: 117 SGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPE-LKGKNIIHAAV--- 171
+ C +++ EG + +G G LG G + S VPE++P L G + +
Sbjct: 341 AACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
Query: 172 ----GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
G H +T+ G ++ G N G G+G Q P R+ G P V V CG +
Sbjct: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRVTMPGEP-VDVACGVDH 455
Query: 228 SMIL 231
+ L
Sbjct: 456 MVTL 459
>AF410455-1|AAM62304.1| 464|Homo sapiens RCC1-like G exchanging
factor-like protein protein.
Length = 464
Score = 68.1 bits (159), Expect = 6e-11
Identities = 61/273 (22%), Positives = 115/273 (42%), Gaps = 34/273 (12%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG--FGDTVTRSVPELVPELKGKN--IIH 168
R++ C HS+++++ ++ G N+ GQ G + S V ++ + ++
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI--KYNGTPIVKVGCGAE 226
A G+ H+LF+TD G VY+CG GQ GLG+ PT++ G +++V +
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 227 FSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYI 286
+ + +G L +G EY QL TD + HF + K
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQ--VNVPRCLHFSGVGK-------------- 337
Query: 287 TPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQK--DENVPRLIKYFDTV 344
+ +CG ++ F WG+G G+ + + E +P +
Sbjct: 338 -------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEF 390
Query: 345 GRGVR--SVHCGGTYSLAVNDQGALFMFGQTKR 375
++ + CG ++ A+ ++G LF++G+ R
Sbjct: 391 NPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
Score = 64.5 bits (150), Expect = 8e-10
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 20/233 (8%)
Query: 105 HKFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGD-TVTRSVPELVPELKG 163
H+ D +++ C HS+ ++++GE Y+ G A GQ G G +T S +L +L G
Sbjct: 223 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
Query: 164 KNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VG 222
N+I A L V+ G ++ G+++ Q + Q+ P + ++G V+
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
Query: 223 CGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSK 282
CG +L+ G++ +G YG LG G V S E IP TL+
Sbjct: 343 CGGTGCAVLNGEGHVFVWG---YGILG---KGPNLVESAVP----EMIPP--TLF----- 385
Query: 283 DGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVP 335
G ++ + + CG +H A+ + F WG G LG +D+ P
Sbjct: 386 -GLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Score = 42.7 bits (96), Expect = 0.003
Identities = 66/299 (22%), Positives = 111/299 (37%), Gaps = 48/299 (16%)
Query: 164 KNIIHAAVGRHHTLF---VTDTGCVYACGDNKSGQCGLGNTTPQ-------ILKPTRIKY 213
+ I AA G TL D V+ G NK Q G + +L+P+ +
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSL 166
Query: 214 -----NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFE 268
T +++V CG S++L + S G YGQ G E
Sbjct: 167 PLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKV------------VENE 214
Query: 269 TIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAE 328
+ ++ + DG + V ++CG +H++ + +S G+G G+ G
Sbjct: 215 IYSESHRVHRMQDFDGQV--------VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266
Query: 329 QKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKRTGEANM------- 381
+ P + D G V V G LAV+ G LF +G ++ A++
Sbjct: 267 YNITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
Query: 382 YPKPVHDLTGWNIKSVGTSNTS-IVIAADDSLIAWGVSPTYGELGMGEINKSTAKPKEV 439
P+ +H ++ T V+ + + WG YG LG G +A P+ +
Sbjct: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMI 380
Score = 35.9 bits (79), Expect = 0.31
Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 14/124 (11%)
Query: 117 SGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRS-VPELVPE-LKGKNIIHAAV--- 171
+ C +++ EG + +G G LG G + S VPE++P L G + +
Sbjct: 341 AACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
Query: 172 ----GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEF 227
G H +T+ G ++ G N G G+G Q P R+ G P V V CG +
Sbjct: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRVTMPGEP-VDVACGVDH 455
Query: 228 SMIL 231
+ L
Sbjct: 456 MVTL 459
>BC040929-1|AAH40929.1| 651|Homo sapiens HERC1 protein protein.
Length = 651
Score = 64.5 bits (150), Expect = 8e-10
Identities = 35/93 (37%), Positives = 49/93 (52%), Gaps = 1/93 (1%)
Query: 119 CTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF 178
C SV ++++G YTFG++ L G + P+ +P L G I AVG HTL
Sbjct: 36 CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA 95
Query: 179 VTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI 211
+ G VYA G N GQ GLG+T + +PT +
Sbjct: 96 LASNGDVYAWGSNSEGQLGLGHTN-HVREPTLV 127
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/149 (26%), Positives = 74/149 (49%), Gaps = 11/149 (7%)
Query: 316 WGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTKR 375
+G G +G+LG ++ P+ I G G++ V CG +S+A+ G ++ FGQ +
Sbjct: 1 FGDGDYGKLGLGNSTAKSSPQKIDVL--CGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 58
Query: 376 TG------EANMYPKPVHDLTGWNIKSVGT-SNTSIVIAADDSLIAWGVSPTYGELGMGE 428
G + P+ + L G I+ V + ++ +A++ + AWG S + G+LG+G
Sbjct: 59 IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG-SNSEGQLGLGH 117
Query: 429 INKSTAKPKEVSRMDSLGITQVAMGYSHT 457
N +P V+ + + Q++ G H+
Sbjct: 118 TN-HVREPTLVTGLQGKNVRQISAGRCHS 145
Score = 50.4 bits (115), Expect = 1e-05
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 2/115 (1%)
Query: 136 FGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQ 195
FG G+LG G++ +S P+ + L G I A G ++ +T G VY G ++
Sbjct: 1 FGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 60
Query: 196 CGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLG 249
G +P +I G I V GAE ++ L NG+++++G GQLG
Sbjct: 61 LPEGRARNH-NRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 114
Score = 49.6 bits (113), Expect = 2e-05
Identities = 48/173 (27%), Positives = 75/173 (43%), Gaps = 28/173 (16%)
Query: 189 GDNKSGQCGLGNTTPQILKPTRIKYN-GTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQ 247
GD G+ GLGN+T + P +I G I KV CG +FS+ L +G++++FG
Sbjct: 2 GDGDYGKLGLGNSTAKS-SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ----- 55
Query: 248 LGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAI 307
D + + H P+QI + + V I D++ G HT+A+
Sbjct: 56 -----DRLIGLPEGRARNHNR--PQQIPV------------LAGVIIEDVAVGAEHTLAL 96
Query: 308 DSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLA 360
S ++WG G+LG P L+ G+ VR + G +S A
Sbjct: 97 ASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ--GKNVRQISAGRCHSAA 147
Score = 47.6 bits (108), Expect = 1e-04
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 121 AGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR-HHTLFV 179
A H++ ++ G+ Y +G N+ GQLG G T P LV L+GKN+ + GR H +
Sbjct: 90 AEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 149
Query: 180 TDTGCVYACGDNKSGQCGLGNTTP 203
A G + Q GL +T P
Sbjct: 150 APPVPPRAPGVSVPLQLGLPDTVP 173
>BC040695-1|AAH40695.1| 358|Homo sapiens WBSCR16 protein protein.
Length = 358
Score = 64.1 bits (149), Expect = 1e-09
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 7/147 (4%)
Query: 113 RLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG--FGDTVTRSVPELVPELKGKN--IIH 168
R++ C HS+++++ ++ G N+ GQ G + S V ++ + ++
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRI--KYNGTPIVKVGCGAE 226
A G+ H+LF+TD G VY+CG GQ GLG+ PT++ G +++V +
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 227 FSMILDCNGNLHSFGMPEYGQLGHNTD 253
+ + +G L +G EY QL TD
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTD 320
Score = 58.4 bits (135), Expect = 5e-08
Identities = 52/203 (25%), Positives = 89/203 (43%), Gaps = 30/203 (14%)
Query: 166 IIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPT----RIKYNGTPIVKV 221
++ + GR H+L +TD V++ G+N GQCG +I + R++ +V+V
Sbjct: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQV 235
Query: 222 GCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKS 281
CG + S+ L G ++S G GQ G G Y +TS+ +
Sbjct: 236 ACGQDHSLFLTDKGEVYSCGWGADGQTGL---GHYNITSSPTKLGGD------------- 279
Query: 282 KDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDE-NVPRLIKY 340
+ V ++ ++ + +A+ + F WG + +L + NVPR + +
Sbjct: 280 -------LAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL-H 331
Query: 341 FDTVGRGVRSVHCGGTYSLAVND 363
F VG+ VR CGGT +ND
Sbjct: 332 FSGVGK-VRQAACGGTGCAVLND 353
Score = 52.4 bits (120), Expect = 3e-06
Identities = 34/130 (26%), Positives = 62/130 (47%), Gaps = 2/130 (1%)
Query: 105 HKFTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGD-TVTRSVPELVPELKG 163
H+ D +++ C HS+ ++++GE Y+ G A GQ G G +T S +L +L G
Sbjct: 223 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
Query: 164 KNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVK-VG 222
N+I A L V+ G ++ G+++ Q + Q+ P + ++G V+
Sbjct: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
Query: 223 CGAEFSMILD 232
CG +L+
Sbjct: 343 CGGTGCAVLN 352
Score = 39.9 bits (89), Expect = 0.019
Identities = 52/226 (23%), Positives = 85/226 (37%), Gaps = 36/226 (15%)
Query: 164 KNIIHAAVGRHHTLF---VTDTGCVYACGDNKSGQCGLGNTTPQ-------ILKPTRIKY 213
+ I AA G TL D V+ G NK Q G + +L+P+ +
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSL 166
Query: 214 -----NGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFE 268
T +++V CG S++L + S G YGQ G E
Sbjct: 167 PLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKV------------VENE 214
Query: 269 TIPKQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAE 328
+ ++ + DG + V ++CG +H++ + +S G+G G+ G
Sbjct: 215 IYSESHRVHRMQDFDGQV--------VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266
Query: 329 QKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFGQTK 374
+ P + D G V V G LAV+ G LF +G ++
Sbjct: 267 YNITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE 311
>BC029174-1|AAH29174.1| 812|Homo sapiens ALS2 protein protein.
Length = 812
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 519 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 578
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 579 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 625
Score = 60.1 bits (139), Expect = 2e-08
Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y CG+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMCGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 55.2 bits (127), Expect = 5e-07
Identities = 55/211 (26%), Positives = 97/211 (45%), Gaps = 30/211 (14%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYN 214
PE +P GK ++ AA+G H + +T+ G VY+ G T P P I
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFG-----------TLPWRSGPVEI-CP 79
Query: 215 GTPIVKVGCGAEFSMILDCNGNLHSFGMPEYG---QLGHNTDGKYFVTSTKLSFHFETIP 271
+PI++ ++ +I G+ HS + + G G N+ G+ V + + + P
Sbjct: 80 SSPILENALVGQY-VITVATGSFHSGAVTDNGVAYMCGENSAGQCAVANQQ----YVPEP 134
Query: 272 KQITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQK 330
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 135 NPVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPV 189
Query: 331 DENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 190 TK--PQKVEHL--AGRVVLQVACGAFHSLAL 216
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 561 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 617
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 618 GRDYSLFLVD 627
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 528 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 587 TFGQLGHS 594
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 529 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 587 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 645
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 646 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 688
>AF391100-1|AAL14103.1| 1657|Homo sapiens alsin protein.
Length = 1657
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 519 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 578
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 579 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 625
Score = 56.4 bits (130), Expect = 2e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLLWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLLWRSGPVEICPSSP-ILENALV- 89
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 90 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 135
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 136 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 190
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 191 K--PQKVEHL--AGRVVLQVACGAFHSLAL 216
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 561 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 617
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 618 GRDYSLFLVD 627
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 528 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 587 TFGQLGHS 594
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 529 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 587 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 645
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 646 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 688
>AC007279-1|AAY15058.1| 1598|Homo sapiens unknown protein.
Length = 1598
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 460 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 519
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 520 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 566
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 502 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 558
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 559 GRDYSLFLVD 568
Score = 45.6 bits (103), Expect = 4e-04
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 9/118 (7%)
Query: 131 GEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGD 190
GE Y+FG + G + + S P L L G+ +I A G H+ VTD G Y G+
Sbjct: 1 GEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGE 58
Query: 191 NKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNGNLHSFG 241
N +GQC + N P+ + +P I+++ CG E ++ L + + ++G
Sbjct: 59 NSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWG 116
Score = 44.4 bits (100), Expect = 9e-04
Identities = 36/119 (30%), Positives = 57/119 (47%), Gaps = 14/119 (11%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVP---------ELKGKNIIHAAVGR 173
HS V++ G AY +G N+ GQ + + VPE P L I+ A G
Sbjct: 43 HSGAVTDNGVAYMWGENSAGQCAVAN--QQYVPEPNPVSIADSEASPLLAVRILQLACGE 100
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKY-NGTPIVKVGCGAEFSMIL 231
HTL ++ + ++A G Q GL T + KP ++++ G +++V CGA S+ L
Sbjct: 101 EHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 157
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 469 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 527
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 528 TFGQLGHS 535
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 511 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 569
Score = 40.3 bits (90), Expect = 0.015
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 5/80 (6%)
Query: 283 DGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKDENVPRLIKYF 341
D +P+ V I+ L+CG HT+A+ + ++WG G G + A + P+ +++
Sbjct: 82 DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTK--PQKVEHL 139
Query: 342 DTVGRGVRSVHCGGTYSLAV 361
GR V V CG +SLA+
Sbjct: 140 --AGRVVLQVACGAFHSLAL 157
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 470 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 527
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 528 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 586
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 587 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 629
>AB053305-1|BAB69014.1| 1657|Homo sapiens ALS2 protein.
Length = 1657
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 519 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 578
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 579 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 625
Score = 55.6 bits (128), Expect = 4e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSP-ILENALV- 89
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 90 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 135
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 136 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 190
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 191 K--PQKVEHL--AGRVVLQVACGAFHSLAL 216
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 561 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 617
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 618 GRDYSLFLVD 627
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 528 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 587 TFGQLGHS 594
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 529 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 587 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 645
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 646 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 688
>AB046783-1|BAB13389.2| 1658|Homo sapiens KIAA1563 protein protein.
Length = 1658
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 520 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 579
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 580 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 626
Score = 55.6 bits (128), Expect = 4e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 53 HGVLLTEDGEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 110
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 111 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 170
Query: 236 NLHSFG 241
+ ++G
Sbjct: 171 EIWAWG 176
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 33 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSP-ILENALV- 90
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 91 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 136
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 137 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 191
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 192 K--PQKVEHL--AGRVVLQVACGAFHSLAL 217
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 562 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 618
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 619 GRDYSLFLVD 628
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 529 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 587
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 588 TFGQLGHS 595
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 571 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 629
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 530 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 587
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 588 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 646
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 647 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 689
>AL359257-2|CAI39759.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 60.1 bits (139), Expect = 2e-08
Identities = 33/89 (37%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 109 DRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIH 168
D R + C HSV++ E G+ YTFG GQLG GD +R P LV L G +
Sbjct: 899 DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQ 957
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
G +HT + G V+ G GQ G
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Score = 52.8 bits (121), Expect = 3e-06
Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 11/110 (10%)
Query: 90 DNNPTK-RTHPNLYTFHKFTDRRYRLIV-SGCTAGHSVLVSEEGEAYTFGRNACGQLGFG 147
D TK R Y K +++V + C G S ++S++GE Y FG++A +
Sbjct: 576 DGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAI----YS 631
Query: 148 DTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
D+ + LV +LKG + A+G+ HT + G V+ G N GQCG
Sbjct: 632 DSSS-----LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
Score = 46.4 bits (105), Expect = 2e-04
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 291 DVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
++ V +SCG +H+V + +++G+G G+LGH + P L++ G +
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP--GPSTQ- 957
Query: 351 VHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V G ++ + G +F FG + G+ +P+ D+ WN K N
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSK-GQLG---RPILDVPYWNAKPAPMPN 1004
Score = 44.0 bits (99), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE 226
+ + G HH++ + + G VY G + GQ G G+ + PT ++ P +V G+
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC-PTLVQALPGPSTQVTAGSN 963
Query: 227 FSMILDCNGNLHSFGMPEYGQLG 249
+ +L +G + +FG GQLG
Sbjct: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
Score = 38.3 bits (85), Expect = 0.059
Identities = 15/32 (46%), Positives = 24/32 (75%)
Query: 219 VKVGCGAEFSMILDCNGNLHSFGMPEYGQLGH 250
V+V CG S++L NG++++FG ++GQLGH
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH 936
Score = 36.7 bits (81), Expect = 0.18
Identities = 31/139 (22%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 118 GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSV----PELVPELKGKNIIHAAVGR 173
G H++LV+E+G + G + G+ G R P+ + +++GK +++ A
Sbjct: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC 233
+ ++ G +Y G + + + + ++ T +K G + +V G + +L
Sbjct: 610 GSSSVISKDGELYMFGKD-----AIYSDSSSLV--TDLK--GHFVTQVAMGKAHTCVLMK 660
Query: 234 NGNLHSFGMPEYGQLGHNT 252
NG + +FG+ GQ G +T
Sbjct: 661 NGEVWTFGVNNKGQCGRDT 679
Score = 31.9 bits (69), Expect = 5.1
Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 350 SVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
SV G+++L V + G++F G + GE K + K + IV+
Sbjct: 548 SVGHDGSHALLVAEDGSIFFTGSASK-GEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTA 606
Query: 410 DSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
+ + V GEL M G+ + V+ + +TQVAMG +HT +L N
Sbjct: 607 CNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKN 661
>AL159158-1|CAI16842.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 60.1 bits (139), Expect = 2e-08
Identities = 33/89 (37%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 109 DRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIH 168
D R + C HSV++ E G+ YTFG GQLG GD +R P LV L G +
Sbjct: 899 DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQ 957
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
G +HT + G V+ G GQ G
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Score = 52.8 bits (121), Expect = 3e-06
Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 11/110 (10%)
Query: 90 DNNPTK-RTHPNLYTFHKFTDRRYRLIV-SGCTAGHSVLVSEEGEAYTFGRNACGQLGFG 147
D TK R Y K +++V + C G S ++S++GE Y FG++A +
Sbjct: 576 DGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAI----YS 631
Query: 148 DTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
D+ + LV +LKG + A+G+ HT + G V+ G N GQCG
Sbjct: 632 DSSS-----LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
Score = 46.4 bits (105), Expect = 2e-04
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 291 DVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
++ V +SCG +H+V + +++G+G G+LGH + P L++ G +
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP--GPSTQ- 957
Query: 351 VHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V G ++ + G +F FG + G+ +P+ D+ WN K N
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSK-GQLG---RPILDVPYWNAKPAPMPN 1004
Score = 44.0 bits (99), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE 226
+ + G HH++ + + G VY G + GQ G G+ + PT ++ P +V G+
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC-PTLVQALPGPSTQVTAGSN 963
Query: 227 FSMILDCNGNLHSFGMPEYGQLG 249
+ +L +G + +FG GQLG
Sbjct: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
Score = 38.3 bits (85), Expect = 0.059
Identities = 15/32 (46%), Positives = 24/32 (75%)
Query: 219 VKVGCGAEFSMILDCNGNLHSFGMPEYGQLGH 250
V+V CG S++L NG++++FG ++GQLGH
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH 936
Score = 36.7 bits (81), Expect = 0.18
Identities = 31/139 (22%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 118 GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSV----PELVPELKGKNIIHAAVGR 173
G H++LV+E+G + G + G+ G R P+ + +++GK +++ A
Sbjct: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC 233
+ ++ G +Y G + + + + ++ T +K G + +V G + +L
Sbjct: 610 GSSSVISKDGELYMFGKD-----AIYSDSSSLV--TDLK--GHFVTQVAMGKAHTCVLMK 660
Query: 234 NGNLHSFGMPEYGQLGHNT 252
NG + +FG+ GQ G +T
Sbjct: 661 NGEVWTFGVNNKGQCGRDT 679
Score = 31.9 bits (69), Expect = 5.1
Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 350 SVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
SV G+++L V + G++F G + GE K + K + IV+
Sbjct: 548 SVGHDGSHALLVAEDGSIFFTGSASK-GEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTA 606
Query: 410 DSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
+ + V GEL M G+ + V+ + +TQVAMG +HT +L N
Sbjct: 607 CNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKN 661
>AL159154-1|CAH73736.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 60.1 bits (139), Expect = 2e-08
Identities = 33/89 (37%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 109 DRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIH 168
D R + C HSV++ E G+ YTFG GQLG GD +R P LV L G +
Sbjct: 899 DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQ 957
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
G +HT + G V+ G GQ G
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Score = 52.8 bits (121), Expect = 3e-06
Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 11/110 (10%)
Query: 90 DNNPTK-RTHPNLYTFHKFTDRRYRLIV-SGCTAGHSVLVSEEGEAYTFGRNACGQLGFG 147
D TK R Y K +++V + C G S ++S++GE Y FG++A +
Sbjct: 576 DGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAI----YS 631
Query: 148 DTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
D+ + LV +LKG + A+G+ HT + G V+ G N GQCG
Sbjct: 632 DSSS-----LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
Score = 46.4 bits (105), Expect = 2e-04
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 291 DVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
++ V +SCG +H+V + +++G+G G+LGH + P L++ G +
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP--GPSTQ- 957
Query: 351 VHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V G ++ + G +F FG + G+ +P+ D+ WN K N
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSK-GQLG---RPILDVPYWNAKPAPMPN 1004
Score = 44.0 bits (99), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE 226
+ + G HH++ + + G VY G + GQ G G+ + PT ++ P +V G+
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC-PTLVQALPGPSTQVTAGSN 963
Query: 227 FSMILDCNGNLHSFGMPEYGQLG 249
+ +L +G + +FG GQLG
Sbjct: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
Score = 38.3 bits (85), Expect = 0.059
Identities = 15/32 (46%), Positives = 24/32 (75%)
Query: 219 VKVGCGAEFSMILDCNGNLHSFGMPEYGQLGH 250
V+V CG S++L NG++++FG ++GQLGH
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH 936
Score = 36.7 bits (81), Expect = 0.18
Identities = 31/139 (22%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 118 GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSV----PELVPELKGKNIIHAAVGR 173
G H++LV+E+G + G + G+ G R P+ + +++GK +++ A
Sbjct: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC 233
+ ++ G +Y G + + + + ++ T +K G + +V G + +L
Sbjct: 610 GSSSVISKDGELYMFGKD-----AIYSDSSSLV--TDLK--GHFVTQVAMGKAHTCVLMK 660
Query: 234 NGNLHSFGMPEYGQLGHNT 252
NG + +FG+ GQ G +T
Sbjct: 661 NGEVWTFGVNNKGQCGRDT 679
Score = 31.9 bits (69), Expect = 5.1
Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 350 SVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
SV G+++L V + G++F G + GE K + K + IV+
Sbjct: 548 SVGHDGSHALLVAEDGSIFFTGSASK-GEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTA 606
Query: 410 DSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
+ + V GEL M G+ + V+ + +TQVAMG +HT +L N
Sbjct: 607 CNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKN 661
>AF075587-1|AAC39928.1| 4641|Homo sapiens protein associated with
Myc protein.
Length = 4641
Score = 60.1 bits (139), Expect = 2e-08
Identities = 33/89 (37%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 109 DRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIH 168
D R + C HSV++ E G+ YTFG GQLG GD +R P LV L G +
Sbjct: 899 DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQ 957
Query: 169 AAVGRHHTLFVTDTGCVYACGDNKSGQCG 197
G +HT + G V+ G GQ G
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Score = 52.4 bits (120), Expect = 3e-06
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 9/84 (10%)
Query: 114 LIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGR 173
++ + C G S ++S++GE Y FG++A + D+ + LV +LKG + A+G+
Sbjct: 602 VVYTACNNGSSSVISKDGELYMFGKDAI----YSDSSS-----LVTDLKGHFVTQVAMGK 652
Query: 174 HHTLFVTDTGCVYACGDNKSGQCG 197
HT + G V+ G N GQCG
Sbjct: 653 AHTCVLMKNGEVWTFGVNNKGQCG 676
Score = 46.4 bits (105), Expect = 2e-04
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 291 DVTIVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRS 350
++ V +SCG +H+V + +++G+G G+LGH + P L++ G +
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP--GPSTQ- 957
Query: 351 VHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSN 401
V G ++ + G +F FG + G+ +P+ D+ WN K N
Sbjct: 958 VTAGSNHTAVLLMDGQVFTFGSFSK-GQLG---RPILDVPYWNAKPAPMPN 1004
Score = 44.0 bits (99), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 167 IHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAE 226
+ + G HH++ + + G VY G + GQ G G+ + PT ++ P +V G+
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC-PTLVQALPGPSTQVTAGSN 963
Query: 227 FSMILDCNGNLHSFGMPEYGQLG 249
+ +L +G + +FG GQLG
Sbjct: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
Score = 38.3 bits (85), Expect = 0.059
Identities = 15/32 (46%), Positives = 24/32 (75%)
Query: 219 VKVGCGAEFSMILDCNGNLHSFGMPEYGQLGH 250
V+V CG S++L NG++++FG ++GQLGH
Sbjct: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH 936
Score = 35.9 bits (79), Expect = 0.31
Identities = 31/139 (22%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 118 GCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSV----PELVPELKGKNIIHAAVGR 173
G H++LV+E+G + G + G+ G R P+ + +++GK +++ A
Sbjct: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESIKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
Query: 174 HHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMILDC 233
+ ++ G +Y G + + + + ++ T +K G + +V G + +L
Sbjct: 610 GSSSVISKDGELYMFGKD-----AIYSDSSSLV--TDLK--GHFVTQVAMGKAHTCVLMK 660
Query: 234 NGNLHSFGMPEYGQLGHNT 252
NG + +FG+ GQ G +T
Sbjct: 661 NGEVWTFGVNNKGQCGRDT 679
Score = 31.1 bits (67), Expect = 8.9
Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 350 SVHCGGTYSLAVNDQGALFMFGQTKRTGEANMYPKPVHDLTGWNIKSVGTSNTSIVIAAD 409
SV G+++L V + G++F G + GE K + K + IV+
Sbjct: 548 SVGHDGSHALLVAEDGSIFFTGSASK-GEDGESIKSRRQSKPYKPKKIIKMEGKIVVYTA 606
Query: 410 DSLIAWGVSPTYGELGM-GEINKSTAKPKEVSRMDSLGITQVAMGYSHTLLLCDN 463
+ + V GEL M G+ + V+ + +TQVAMG +HT +L N
Sbjct: 607 CNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKN 661
>BC071576-1|AAH71576.1| 1237|Homo sapiens ALS2 protein protein.
Length = 1237
Score = 59.7 bits (138), Expect = 2e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 1/108 (0%)
Query: 124 SVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTG 183
++L S E +T+G+ GQLG GD + R P V L GK +IH G +H+L +T
Sbjct: 519 ALLPSLRIEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS 578
Query: 184 CVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
VY+ G N GQ G + + + +I + + + G ++S+ L
Sbjct: 579 QVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAGRDYSLFL 625
Score = 55.6 bits (128), Expect = 4e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSP-ILENALV- 89
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 90 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 135
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 136 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 190
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 191 K--PQKVEHL--AGRVVLQVACGAFHSLAL 216
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
++ L G H++A+ + + +SWG FG+LGH++ VPRL K + GV S+
Sbjct: 561 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKI--SSENGVWSIAA 617
Query: 354 GGTYSLAVND 363
G YSL + D
Sbjct: 618 GRDYSLFLVD 627
Score = 43.2 bits (97), Expect = 0.002
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 185 VYACGDNKSGQCGLGNTTPQILKPTRIK-YNGTPIVKVGCGAEFSMILDCNGNLHSFGMP 243
V+ G K GQ G G+ P+ L+P +K +G ++ + G S+ L ++S+G
Sbjct: 528 VWTWGKGKEGQLGHGDVLPR-LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 244 EYGQLGHN 251
+GQLGH+
Sbjct: 587 TFGQLGHS 594
Score = 42.3 bits (95), Expect = 0.004
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
HS+ ++ + + Y++G N GQLG D T +VP L + A GR ++LF+ DT
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
Score = 36.3 bits (80), Expect = 0.24
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 314 FSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALF----- 368
++WG G G+LGH + P +K D G+ V + GG +SLA+ + ++
Sbjct: 529 WTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 369 MFGQTKRTGEANMYPK--PVHDLTG-WNIKSVGTSNTSIVIAADD---SLIAWG-VSPTY 421
FGQ + P+ + G W+I + G + ++ +D L G PT
Sbjct: 587 TFGQLGHSDFPTTVPRLAKISSENGVWSI-AAGRDYSLFLVDTEDFQPGLYYSGRQDPTE 645
Query: 422 GELGMGEINKSTAKPKEVSRMDSLG-ITQVAMGYSHTLLLCDNNI 465
G+ + E N S +K + LG I++V G L L D NI
Sbjct: 646 GD-NLPE-NHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNI 688
>AK023024-1|BAB14362.1| 396|Homo sapiens protein ( Homo sapiens
cDNA FLJ12962 fis, clone NT2RP2005694, weakly similar to
X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR. ).
Length = 396
Score = 56.4 bits (130), Expect = 2e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLLWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLLWRSGPVEICPSSP-ILENALV- 89
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 90 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 135
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 136 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 190
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 191 K--PQKVEHL--AGRVVLQVACGAFHSLAL 216
>AB053306-1|BAB69015.1| 396|Homo sapiens ALS2 protein.
Length = 396
Score = 55.6 bits (128), Expect = 4e-07
Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)
Query: 123 HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDT 182
H VL++E+GE Y+FG + G + + S P L L G+ +I A G H+ VTD
Sbjct: 52 HGVLLTEDGEVYSFG-TLPWRSGPVE-ICPSSPILENALVGQYVITVATGSFHSGAVTDN 109
Query: 183 GCVYACGDNKSGQCGLGNT--TPQILKPTRIKYNGTP-----IVKVGCGAEFSMILDCNG 235
G Y G+N +GQC + N P+ + +P I+++ CG E ++ L +
Sbjct: 110 GVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR 169
Query: 236 NLHSFG 241
+ ++G
Sbjct: 170 EIWAWG 175
Score = 54.8 bits (126), Expect = 6e-07
Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 28/210 (13%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDN--KSGQCGLGNTTPQILKPTRIK 212
PE +P GK ++ AA+G H + +T+ G VY+ G +SG + ++P IL+ +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSP-ILENALV- 89
Query: 213 YNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPK 272
G ++ V G+ S + NG + +G N+ G+ V + + + P
Sbjct: 90 --GQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQQ----YVPEPN 135
Query: 273 QITLYIQKSKDGYITPVKDVTIVDLSCGNNHTVAIDSMKRAFSWGFG-GFGRLGHAEQKD 331
+++ D +P+ V I+ L+CG HT+A+ + ++WG G G + A
Sbjct: 136 PVSI-----ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT 190
Query: 332 ENVPRLIKYFDTVGRGVRSVHCGGTYSLAV 361
+ P+ +++ GR V V CG +SLA+
Sbjct: 191 K--PQKVEHL--AGRVVLQVACGAFHSLAL 216
>BC113826-1|AAI13827.1| 244|Homo sapiens RCCD1 protein protein.
Length = 244
Score = 53.6 bits (123), Expect = 1e-06
Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 2/69 (2%)
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
V SCG+ HT + ++WG+G +G+LGH + + PR ++YF V++V CG
Sbjct: 171 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 230
Query: 355 --GTYSLAV 361
TY AV
Sbjct: 231 PWNTYVYAV 239
Score = 44.4 bits (100), Expect = 9e-04
Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 130 EGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACG 189
E E + F R+ GQLG G P L+ L+G + A G H++ V++TG +Y G
Sbjct: 45 ELELHRF-RDPHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 103
Query: 190 DNKSGQCGL 198
N+SGQ L
Sbjct: 104 WNESGQLAL 112
Score = 43.2 bits (97), Expect = 0.002
Identities = 42/139 (30%), Positives = 60/139 (43%), Gaps = 16/139 (11%)
Query: 114 LIVSGCTAG--HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
L+++ AG HSV VSE G+ Y +G N GQL TR++ E G+ V
Sbjct: 78 LVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALP---TRNLAE-----DGET-----V 124
Query: 172 GRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
R T D V G + G Q G+ VK CG+ + ++
Sbjct: 125 AREATELNEDGSQVKRTGGAEDG-APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVV 183
Query: 232 DCNGNLHSFGMPEYGQLGH 250
G L+++G +YGQLGH
Sbjct: 184 TRTGELYTWGWGKYGQLGH 202
Score = 39.9 bits (89), Expect = 0.019
Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 155 PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKY 213
P L+ G + + A+ G HT VT TG +Y G K GQ G +TT + +P R++Y
Sbjct: 159 PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-SLDRPRRVEY 216
Score = 36.7 bits (81), Expect = 0.18
Identities = 19/57 (33%), Positives = 28/57 (49%)
Query: 115 IVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV 171
+ + C + H+ +V+ GE YT+G GQLG DT + P V K + AV
Sbjct: 171 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAV 227
>AF225404-1|AAO27482.1| 259|Homo sapiens HERC2 protein.
Length = 259
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 131 GEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLF-VTDTGCVYACG 189
G Y +G N GQLG + VP L + +G TLF VT G +YA G
Sbjct: 127 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQ-LIGGEQTLFAVTADGKLYATG 185
Query: 190 DNKSGQCGLGNT----TPQILKPTRIKYNGTPIVKVGCGAEFSMILDCNGNLHSFGMPEY 245
G+ G+G T TP +L+ I++ V V G + + L G ++S+G E
Sbjct: 186 YGAGGRLGIGGTESVSTPTLLE--SIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAED 243
Query: 246 GQLGH 250
G+LGH
Sbjct: 244 GKLGH 248
Score = 48.4 bits (110), Expect = 6e-05
Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 2/79 (2%)
Query: 127 VSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAV--GRHHTLFVTDTGC 184
V+ +G+ Y G A G+LG G T + S P L+ ++ I AV G H L ++ G
Sbjct: 175 VTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE 234
Query: 185 VYACGDNKSGQCGLGNTTP 203
VY+ G+ + G+ G GN +P
Sbjct: 235 VYSWGEAEDGKLGHGNRSP 253
Score = 39.5 bits (88), Expect = 0.026
Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Query: 295 VDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHCG 354
V L G A+ + + ++ G+G GRLG + + P L++ V +V+ G
Sbjct: 163 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 222
Query: 355 GTYSLAVNDQGALFMFGQTK--RTGEANMYP 383
G + LA++ +G ++ +G+ + + G N P
Sbjct: 223 GKHCLALSSEGEVYSWGEAEDGKLGHGNRSP 253
Score = 37.5 bits (83), Expect = 0.10
Identities = 43/164 (26%), Positives = 71/164 (43%), Gaps = 26/164 (15%)
Query: 176 TLFVTDTGCVYACGDNKSGQCGLGNTTPQILKPTRIKYNGT--PIVKVGCGAEFSMILDC 233
TL +G +Y G N GQ G G ++ PT + T P+ +G G + +
Sbjct: 120 TLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIG-GEQTLFAVTA 177
Query: 234 NGNLHSFGMPEYGQLGHNTDGKYFVTSTKLSFHFETIPKQITLYIQKSKDGYITPVKDVT 293
+G L++ G G+LG G V++ L E+I ++I+K
Sbjct: 178 DGKLYATGYGAGGRLG--IGGTESVSTPTL---LESIQH---VFIKK------------- 216
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRL 337
V ++ G H +A+ S +SWG G+LGH + + PR+
Sbjct: 217 -VAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRV 259
>AY650032-1|AAV66578.1| 117|Homo sapiens HECT and RCC1 containing
protein 4 isoform 2 protein.
Length = 117
Score = 44.0 bits (99), Expect = 0.001
Identities = 29/80 (36%), Positives = 35/80 (43%), Gaps = 4/80 (5%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCG--LGNTTPQILKPTRI 211
GQ G P+ILK +I
Sbjct: 64 GQLGHEKSRKKPEILKVCQI 83
Score = 37.1 bits (82), Expect = 0.14
Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGK 255
GQLGH K
Sbjct: 63 LGQLGHEKSRK 73
Score = 34.7 bits (76), Expect = 0.73
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 4/52 (7%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELV 158
F ++R R + GC H+V V ++G YT G N GQL G +R PE++
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQL--GHEKSRKKPEIL 78
Score = 33.1 bits (72), Expect = 2.2
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 4/58 (6%)
Query: 316 WGFGGFGRLGHAEQKDENV--PRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFG 371
WG FG+LG +E V PR +F + + VR V CG +++ V D G ++ G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
>BC067293-1|AAH67293.1| 580|Homo sapiens F-box protein 24 protein.
Length = 580
Score = 41.5 bits (93), Expect = 0.006
Identities = 44/152 (28%), Positives = 73/152 (48%), Gaps = 16/152 (10%)
Query: 92 NPTKRTHPNLYT----FHKFTDRRYRLIVSGCTAGHS--VLVSEEG----EAYTFG--RN 139
N T+ P YT K + L V+ T+ S + V+++G E +T G R+
Sbjct: 275 NETQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRD 334
Query: 140 ACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLG 199
G L D + + +P L L K I+ A+G +H V + G ++ G+N+ GQ G G
Sbjct: 335 LFGTLQAFDPLDQQMP-LALSLPAK-ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTG 392
Query: 200 NTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
+ + +PT++ Y PI + CG S++L
Sbjct: 393 DKMDR-GEPTQVCYLQRPIT-LWCGLNHSLVL 422
Score = 31.9 bits (69), Expect = 5.1
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 119 CTAG--HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHT 176
C G H LV E G + G N GQLG GD + R P V L + I G +H+
Sbjct: 362 CALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYL--QRPITLWCGLNHS 419
Query: 177 LFVTDT 182
L ++ +
Sbjct: 420 LVLSQS 425
Score = 31.1 bits (67), Expect = 8.9
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
I+ + G NH +D R F G +G+LG ++ D P + Y R + ++ C
Sbjct: 359 ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQ---RPI-TLWC 414
Query: 354 GGTYSLAVN 362
G +SL ++
Sbjct: 415 GLNHSLVLS 423
>AC069281-1|AAP21863.1| 580|Homo sapiens unknown protein.
Length = 580
Score = 41.5 bits (93), Expect = 0.006
Identities = 44/152 (28%), Positives = 73/152 (48%), Gaps = 16/152 (10%)
Query: 92 NPTKRTHPNLYT----FHKFTDRRYRLIVSGCTAGHS--VLVSEEG----EAYTFG--RN 139
N T+ P YT K + L V+ T+ S + V+++G E +T G R+
Sbjct: 275 NETQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRD 334
Query: 140 ACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKSGQCGLG 199
G L D + + +P L L K I+ A+G +H V + G ++ G+N+ GQ G G
Sbjct: 335 LFGTLQAFDPLDQQMP-LALSLPAK-ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTG 392
Query: 200 NTTPQILKPTRIKYNGTPIVKVGCGAEFSMIL 231
+ + +PT++ Y PI + CG S++L
Sbjct: 393 DKMDR-GEPTQVCYLQRPIT-LWCGLNHSLVL 422
Score = 31.9 bits (69), Expect = 5.1
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 119 CTAG--HSVLVSEEGEAYTFGRNACGQLGFGDTVTRSVPELVPELKGKNIIHAAVGRHHT 176
C G H LV E G + G N GQLG GD + R P V L + I G +H+
Sbjct: 362 CALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYL--QRPITLWCGLNHS 419
Query: 177 LFVTDT 182
L ++ +
Sbjct: 420 LVLSQS 425
Score = 31.1 bits (67), Expect = 8.9
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 294 IVDLSCGNNHTVAIDSMKRAFSWGFGGFGRLGHAEQKDENVPRLIKYFDTVGRGVRSVHC 353
I+ + G NH +D R F G +G+LG ++ D P + Y R + ++ C
Sbjct: 359 ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQ---RPI-TLWC 414
Query: 354 GGTYSLAVN 362
G +SL ++
Sbjct: 415 GLNHSLVLS 423
>AY650034-1|AAV66580.1| 110|Homo sapiens HECT and RCC1 containing
protein 4 isoform 4 protein.
Length = 110
Score = 41.1 bits (92), Expect = 0.008
Identities = 24/64 (37%), Positives = 28/64 (43%), Gaps = 2/64 (3%)
Query: 136 FGRNACGQLGFGDTVTRSV--PELVPELKGKNIIHAAVGRHHTLFVTDTGCVYACGDNKS 193
+G + GQLG G V P K + G HT+FV D G VY CG N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 194 GQCG 197
GQ G
Sbjct: 64 GQLG 67
Score = 37.1 bits (82), Expect = 0.14
Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 188 CGDNKS-GQCGLGNTTPQI-LKPTRIKYNGTPIVK-VGCGAEFSMILDCNGNLHSFGMPE 244
C N S GQ GLG +I L+P + + V+ VGCG ++ + +G +++ G +
Sbjct: 3 CWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCND 62
Query: 245 YGQLGHNTDGK 255
GQLGH K
Sbjct: 63 LGQLGHEKSRK 73
Score = 33.9 bits (74), Expect = 1.3
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 107 FTDRRYRLIVSGCTAGHSVLVSEEGEAYTFGRNACGQLG 145
F ++R R + GC H+V V ++G YT G N GQLG
Sbjct: 31 FINKRVRDV--GCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Score = 33.1 bits (72), Expect = 2.2
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 4/58 (6%)
Query: 316 WGFGGFGRLGHAEQKDENV--PRLIKYFDTVGRGVRSVHCGGTYSLAVNDQGALFMFG 371
WG FG+LG +E V PR +F + + VR V CG +++ V D G ++ G
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTCG 59
>BC009336-1|AAH09336.2| 326|Homo sapiens NEK9 protein protein.
Length = 326
Score = 32.7 bits (71), Expect = 2.9
Identities = 13/28 (46%), Positives = 17/28 (60%)
Query: 297 LSCGNNHTVAIDSMKRAFSWGFGGFGRL 324
+SCG+ T+A F+WG GG GRL
Sbjct: 2 VSCGDEFTIAATDDNHIFAWGNGGNGRL 29
>BC059408-1|AAH59408.1| 267|Homo sapiens ovo-like 1(Drosophila)
protein.
Length = 267
Score = 31.1 bits (67), Expect = 8.9
Identities = 23/68 (33%), Positives = 29/68 (42%), Gaps = 3/68 (4%)
Query: 42 PAEQSKPSTPEPEECTTKLPEELLKTFYK-TPGVLMIAGLVSWDLTARRDNNPTKRTHPN 100
P + +PS EP C L L + Y PG ++A L S D+ D P R H
Sbjct: 43 PYREPEPSVAEPPSCPLALNMSLRDSSYSMAPGPCVVAQLPSEDMGHLTD--PQSRDHGF 100
Query: 101 LYTFHKFT 108
L T K T
Sbjct: 101 LRTKMKVT 108
>BC043146-1|AAH43146.1| 244|Homo sapiens OVOL1 protein protein.
Length = 244
Score = 31.1 bits (67), Expect = 8.9
Identities = 23/68 (33%), Positives = 29/68 (42%), Gaps = 3/68 (4%)
Query: 42 PAEQSKPSTPEPEECTTKLPEELLKTFYK-TPGVLMIAGLVSWDLTARRDNNPTKRTHPN 100
P + +PS EP C L L + Y PG ++A L S D+ D P R H
Sbjct: 20 PYREPEPSVAEPPSCPLALNMSLRDSSYSMAPGPCVVAQLPSEDMGHLTD--PQSRDHGF 77
Query: 101 LYTFHKFT 108
L T K T
Sbjct: 78 LRTKMKVT 85
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.317 0.135 0.410
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 74,733,594
Number of Sequences: 224733
Number of extensions: 3358649
Number of successful extensions: 8434
Number of sequences better than 10.0: 103
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 6634
Number of HSP's gapped (non-prelim): 833
length of query: 480
length of database: 73,234,838
effective HSP length: 93
effective length of query: 387
effective length of database: 52,334,669
effective search space: 20253516903
effective search space used: 20253516903
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 67 (31.1 bits)
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