Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002085-TA|BGIBMGA002085-PA|IPR001128|Cytochrome P450,
IPR002401|E-class P450, group I
(498 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 230 7e-60
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 230 7e-60
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 230 7e-60
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 230 7e-60
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 230 1e-59
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 198 4e-50
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 195 3e-49
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 195 3e-49
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 195 3e-49
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 195 3e-49
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 195 3e-49
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 195 3e-49
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 195 3e-49
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 195 3e-49
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 195 3e-49
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 195 3e-49
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 195 3e-49
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 195 3e-49
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 194 6e-49
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 194 6e-49
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 194 8e-49
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 194 8e-49
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 194 8e-49
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 194 8e-49
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 193 1e-48
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 193 1e-48
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 193 1e-48
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 192 2e-48
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 192 2e-48
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 192 2e-48
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 192 2e-48
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 192 2e-48
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 192 2e-48
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 192 3e-48
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 192 3e-48
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 190 7e-48
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 190 1e-47
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 190 1e-47
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 190 1e-47
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 190 1e-47
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 190 1e-47
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 190 1e-47
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 190 1e-47
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 189 2e-47
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 189 2e-47
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 189 2e-47
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 189 2e-47
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 189 2e-47
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 189 2e-47
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 189 2e-47
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 189 2e-47
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 189 2e-47
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 188 3e-47
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 188 3e-47
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 188 3e-47
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 188 3e-47
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 188 3e-47
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 188 5e-47
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 188 5e-47
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 187 7e-47
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 187 7e-47
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 186 1e-46
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 186 2e-46
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 186 2e-46
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 186 2e-46
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 186 2e-46
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 185 3e-46
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 185 3e-46
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 185 3e-46
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 185 3e-46
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 185 3e-46
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 185 3e-46
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 183 1e-45
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 183 1e-45
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 182 3e-45
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 181 6e-45
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 179 2e-44
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 179 2e-44
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 179 2e-44
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 179 2e-44
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 179 2e-44
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 179 2e-44
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 178 3e-44
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 177 7e-44
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 175 3e-43
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 175 4e-43
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 174 7e-43
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 171 4e-42
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 171 4e-42
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 171 4e-42
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 171 4e-42
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 171 4e-42
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 171 4e-42
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 171 4e-42
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 171 4e-42
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 171 4e-42
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 171 4e-42
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 171 4e-42
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 171 4e-42
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 171 4e-42
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 171 5e-42
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 171 5e-42
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 171 5e-42
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 171 6e-42
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 171 6e-42
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 171 6e-42
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 171 6e-42
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 170 1e-41
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 169 2e-41
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 169 3e-41
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 168 3e-41
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 164 6e-40
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 164 6e-40
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 164 7e-40
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 164 7e-40
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 164 7e-40
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 163 1e-39
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 163 1e-39
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 160 1e-38
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 159 2e-38
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 159 2e-38
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 159 2e-38
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 157 8e-38
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 157 1e-37
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 155 3e-37
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 155 3e-37
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 155 3e-37
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 152 3e-36
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 152 3e-36
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 151 7e-36
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 151 7e-36
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 151 7e-36
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 151 7e-36
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 151 7e-36
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 151 7e-36
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 150 1e-35
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 150 1e-35
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 144 6e-34
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 143 1e-33
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 142 2e-33
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 142 2e-33
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 139 2e-32
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 138 4e-32
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 134 5e-31
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 132 3e-30
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 132 3e-30
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 131 5e-30
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 131 5e-30
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 130 1e-29
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 126 2e-28
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 125 3e-28
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 125 3e-28
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 125 3e-28
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 125 3e-28
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 125 3e-28
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 125 3e-28
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 125 3e-28
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 125 3e-28
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 125 3e-28
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 125 4e-28
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 125 4e-28
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 125 4e-28
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 125 4e-28
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 125 4e-28
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 125 4e-28
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 125 4e-28
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 125 4e-28
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 125 4e-28
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 125 4e-28
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 125 4e-28
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 125 4e-28
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 125 4e-28
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 125 4e-28
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 124 5e-28
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 124 5e-28
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 124 5e-28
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 124 7e-28
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 124 7e-28
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 124 1e-27
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 123 1e-27
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 123 1e-27
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 123 1e-27
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 123 1e-27
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 123 1e-27
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 123 2e-27
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 123 2e-27
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 123 2e-27
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 122 4e-27
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 120 2e-26
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 119 3e-26
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 118 4e-26
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 108 4e-23
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 108 5e-23
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 103 1e-21
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 103 1e-21
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 101 4e-21
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 101 4e-21
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 101 6e-21
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 101 6e-21
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 101 6e-21
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 101 6e-21
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 101 6e-21
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 101 6e-21
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 101 6e-21
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 101 6e-21
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 101 6e-21
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 101 6e-21
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 101 8e-21
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 100 1e-20
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 100 1e-20
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 100 1e-20
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 100 1e-20
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 100 1e-20
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 100 1e-20
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 100 1e-20
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 99 3e-20
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 99 3e-20
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 99 3e-20
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 99 3e-20
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 97 2e-19
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 97 2e-19
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 96 2e-19
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 96 2e-19
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 95 7e-19
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 92 4e-18
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 92 4e-18
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 92 4e-18
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 92 4e-18
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 89 4e-17
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 87 1e-16
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 87 1e-16
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 87 2e-16
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 87 2e-16
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 87 2e-16
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 87 2e-16
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 85 4e-16
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 85 5e-16
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 85 5e-16
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 83 2e-15
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 83 2e-15
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 83 2e-15
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 81 9e-15
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 81 9e-15
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 81 9e-15
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 81 9e-15
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 81 1e-14
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 79 4e-14
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 79 4e-14
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 79 4e-14
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 79 4e-14
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 79 4e-14
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 79 4e-14
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 79 4e-14
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 79 4e-14
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 79 4e-14
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 75 4e-13
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 72 5e-12
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 72 5e-12
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 72 5e-12
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 72 5e-12
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 70 2e-11
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 69 4e-11
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 69 4e-11
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 69 4e-11
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 69 4e-11
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 68 7e-11
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 68 7e-11
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 68 7e-11
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 68 9e-11
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 67 1e-10
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 67 1e-10
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 67 1e-10
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 67 1e-10
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 67 1e-10
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 67 1e-10
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 67 1e-10
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 67 2e-10
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 67 2e-10
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 67 2e-10
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 67 2e-10
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 67 2e-10
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 66 2e-10
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 66 2e-10
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 66 4e-10
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 66 4e-10
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 66 4e-10
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 66 4e-10
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 65 5e-10
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 65 6e-10
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 65 6e-10
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 65 6e-10
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 65 6e-10
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 65 6e-10
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 65 6e-10
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 65 6e-10
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 65 6e-10
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 64 8e-10
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 64 8e-10
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 64 8e-10
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 64 8e-10
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 64 8e-10
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 64 8e-10
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 64 1e-09
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 62 3e-09
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 62 4e-09
BC109056-1|AAI09057.1| 320|Homo sapiens CYP2F1 protein protein. 62 6e-09
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 61 8e-09
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 61 8e-09
L16880-1|AAD13466.1| 273|Homo sapiens cytochrome P-450 2C protein. 61 1e-08
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 61 1e-08
BC070317-1|AAH70317.1| 162|Homo sapiens CYP2C9 protein protein. 61 1e-08
BC020754-1|AAH20754.1| 162|Homo sapiens CYP2C9 protein protein. 61 1e-08
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 60 2e-08
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 60 2e-08
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 60 2e-08
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 60 2e-08
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 60 2e-08
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 60 2e-08
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 59 4e-08
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 59 4e-08
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 59 4e-08
L39098-1|AAL31347.1| 160|Homo sapiens S-mephenytoin 4-hydroxyla... 58 5e-08
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 57 1e-07
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 57 1e-07
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 57 1e-07
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 57 1e-07
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 57 1e-07
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 57 1e-07
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 57 1e-07
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 56 3e-07
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 56 3e-07
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 55 7e-07
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 55 7e-07
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 55 7e-07
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 55 7e-07
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 55 7e-07
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 55 7e-07
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 54 1e-06
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 54 1e-06
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 54 2e-06
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 54 2e-06
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 53 2e-06
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 53 2e-06
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 53 2e-06
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 53 2e-06
S63426-1|ABB76283.1| 214|Homo sapiens (S)-mephenytoin hydroxyla... 53 3e-06
DQ359216-1|ABC95161.1| 347|Homo sapiens dioxin-inducible cytoch... 52 4e-06
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 52 4e-06
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 52 4e-06
AY904366-1|AAW83816.1| 62|Homo sapiens cytochrome p4502C9 prot... 52 4e-06
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 52 4e-06
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 52 6e-06
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 52 6e-06
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 52 6e-06
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 50 2e-05
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 50 2e-05
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 50 2e-05
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 49 4e-05
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 49 4e-05
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 49 4e-05
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 49 4e-05
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 49 4e-05
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 49 4e-05
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 49 4e-05
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 49 4e-05
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 49 4e-05
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 49 4e-05
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 49 4e-05
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 49 4e-05
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 49 4e-05
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 49 4e-05
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 49 4e-05
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 48 6e-05
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 48 6e-05
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 48 8e-05
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 47 1e-04
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 47 1e-04
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 47 1e-04
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 47 1e-04
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 46 2e-04
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 46 2e-04
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 46 3e-04
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 45 7e-04
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 45 7e-04
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 45 7e-04
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 44 0.001
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 43 0.002
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 43 0.002
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 43 0.002
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 43 0.002
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 43 0.002
S80997-1|AAB35962.1| 44|Homo sapiens CYP2G1 homolog protein. 43 0.003
AM236046-1|CAJ84703.1| 229|Homo sapiens cytochrome P450 1A1 pro... 43 0.003
D50111-1|BAA08796.1| 46|Homo sapiens CYP2EI protein. 42 0.005
DQ915490-1|ABI95134.1| 58|Homo sapiens cytochrome P4502D6 prot... 42 0.007
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 41 0.012
AM233520-1|CAJ80723.1| 189|Homo sapiens cytochrome P450 1A1 pro... 40 0.020
AM233519-1|CAJ80722.1| 189|Homo sapiens cytochrome P450 1A1 pro... 40 0.020
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 40 0.027
DQ915489-1|ABI95133.1| 58|Homo sapiens cytochrome P4502D6 prot... 40 0.027
DQ915488-1|ABI95132.1| 58|Homo sapiens cytochrome P4502D6 prot... 40 0.027
DQ915487-1|ABI95131.1| 58|Homo sapiens cytochrome P4502D6 prot... 40 0.027
DQ915486-1|ABI95130.1| 58|Homo sapiens cytochrome P4502D6 prot... 40 0.027
DQ915485-1|ABI95129.1| 58|Homo sapiens cytochrome P4502D6 prot... 40 0.027
BC067441-1|AAH67441.1| 501|Homo sapiens cytochrome P450, family... 40 0.027
BC067434-1|AAH67434.1| 501|Homo sapiens cytochrome P450, family... 40 0.027
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 40 0.027
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 40 0.027
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 40 0.027
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 39 0.047
M93133-1|AAA58435.1| 504|Homo sapiens cholesterol 7-alpha hydro... 39 0.047
BC112184-1|AAI12185.1| 504|Homo sapiens cytochrome P450, family... 39 0.047
BC101777-1|AAI01778.1| 504|Homo sapiens cytochrome P450, family... 39 0.047
BC067442-1|AAH67442.1| 501|Homo sapiens cytochrome P450, family... 37 0.14
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 37 0.14
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 37 0.14
AF090320-1|AAD19877.1| 501|Homo sapiens sterol 12-alpha-hydroxy... 37 0.14
AF090318-1|AAC63037.1| 462|Homo sapiens sterol 12-alpha hydroxy... 37 0.14
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 36 0.25
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 36 0.25
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 36 0.25
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 35 0.58
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 35 0.76
X58907-1|CAA41710.1| 369|Homo sapiens steroid 21-monooxygenase ... 34 1.0
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 34 1.3
AK131497-1|BAD18641.1| 930|Homo sapiens protein ( Homo sapiens ... 34 1.3
AF326721-1|AAG45229.1| 49|Homo sapiens cytochrome P450 2A6 pro... 33 2.3
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 33 3.1
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 32 4.1
S77873-1|AAD14267.1| 68|Homo sapiens CYP2E1 protein. 31 7.1
D63477-1|BAA09764.1| 885|Homo sapiens KIAA0143 protein. 31 7.1
BC131486-1|AAI31487.1| 674|Homo sapiens KIAA0143 protein protein. 31 7.1
BC108667-1|AAI08668.1| 578|Homo sapiens KIAA0143 protein protein. 31 7.1
BC071611-1|AAH71611.1| 888|Homo sapiens KIAA0143 protein protein. 31 7.1
X77343-1|CAB59735.1| 437|Homo sapiens transcription factor AP-2... 31 9.4
X52611-1|CAA36842.1| 437|Homo sapiens protein ( Human mRNA for ... 31 9.4
U77845-1|AAB52993.1| 469|Homo sapiens hTRIP protein. 31 9.4
M36711-1|AAA35539.1| 437|Homo sapiens protein ( Human sequence-... 31 9.4
BC017754-1|AAH17754.1| 431|Homo sapiens transcription factor AP... 31 9.4
AY513607-1|AAR90938.1| 100|Homo sapiens truncated cytochrome P4... 31 9.4
AL138885-5|CAI20065.1| 433|Homo sapiens transcription factor AP... 31 9.4
AL138885-3|CAC38370.1| 439|Homo sapiens transcription factor AP... 31 9.4
AL138885-2|CAI20064.1| 431|Homo sapiens transcription factor AP... 31 9.4
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 230 bits (563), Expect = 7e-60
Identities = 134/480 (27%), Positives = 237/480 (49%), Gaps = 19/480 (3%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 39 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 90
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 150
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 151 GKKSLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 264
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 265 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 323
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE R VP
Sbjct: 324 LLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPRE 383
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGL 438
DTTLAG H+P+ TM+++N T + D + P +F P+ FL NG+ + + PF +
Sbjct: 384 VTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSI 443
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI 498
K C+G+ LA+ +F+F T+++Q+F+ P E L SL G T S + +P++
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLCAVPQV 502
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 230 bits (563), Expect = 7e-60
Identities = 134/480 (27%), Positives = 237/480 (49%), Gaps = 19/480 (3%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 39 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 90
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 150
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 151 GKKSLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 264
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 265 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 323
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE R VP
Sbjct: 324 LLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPRE 383
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGL 438
DTTLAG H+P+ TM+++N T + D + P +F P+ FL NG+ + + PF +
Sbjct: 384 VTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSI 443
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI 498
K C+G+ LA+ +F+F T+++Q+F+ P E L SL G T S + +P++
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLCAVPQV 502
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 230 bits (563), Expect = 7e-60
Identities = 134/480 (27%), Positives = 237/480 (49%), Gaps = 19/480 (3%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 39 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 90
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 150
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 151 GKKSLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 264
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 265 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 323
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE R VP
Sbjct: 324 LLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPRE 383
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGL 438
DTTLAG H+P+ TM+++N T + D + P +F P+ FL NG+ + + PF +
Sbjct: 384 VTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSI 443
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI 498
K C+G+ LA+ +F+F T+++Q+F+ P E L SL G T S + +P++
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLCAVPQV 502
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 230 bits (563), Expect = 7e-60
Identities = 134/480 (27%), Positives = 237/480 (49%), Gaps = 19/480 (3%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 39 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 90
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 150
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 151 GKKSLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 264
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 265 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 323
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE R VP
Sbjct: 324 LLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPRE 383
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGL 438
DTTLAG H+P+ TM+++N T + D + P +F P+ FL NG+ + + PF +
Sbjct: 384 VTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSI 443
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI 498
K C+G+ LA+ +F+F T+++Q+F+ P E L SL G T S + +P++
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLCAVPQV 502
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 230 bits (562), Expect = 1e-59
Identities = 134/480 (27%), Positives = 237/480 (49%), Gaps = 19/480 (3%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 39 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 90
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 150
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 151 GKKSLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 264
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 265 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 323
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE R VP
Sbjct: 324 LLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPRE 383
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGL 438
DTTLAG H+P+ TM+++N T + D + P +F P+ FL NG+ + + PF +
Sbjct: 384 VTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSI 443
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI 498
K C+G+ LA+ +F+F T+++Q+F+ P E L SL G T S + +P++
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL-SLKFRMGITISPVSHRLCAVPQV 502
>M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrome
P-450 1 functional form mRNA, complete cds. ).
Length = 490
Score = 198 bits (483), Expect = 4e-50
Identities = 133/452 (29%), Positives = 223/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + +L+ FG
Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTNLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DFMD ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 370 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 430 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
>Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein.
Length = 490
Score = 195 bits (476), Expect = 3e-49
Identities = 132/452 (29%), Positives = 222/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG
Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 370 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 430 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
>J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrome
P450IIE1 (ethanol-inducible) gene, complete cds. ).
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrome
P-450j mRNA, complete cds. ).
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1
protein.
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLADCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPAWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARTELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 195 bits (476), Expect = 3e-49
Identities = 132/452 (29%), Positives = 222/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG
Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 370 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 430 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
>AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 195 bits (476), Expect = 3e-49
Identities = 132/452 (29%), Positives = 222/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG
Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 370 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 430 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
>AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1
protein.
Length = 462
Score = 195 bits (476), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 2 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 53
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 54 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 109
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 110 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 165
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 166 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 223
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 224 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 282
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 283 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 342
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 343 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 402
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 403 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 460
Query: 497 R 497
R
Sbjct: 461 R 461
>M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein.
Length = 480
Score = 195 bits (475), Expect = 3e-49
Identities = 132/452 (29%), Positives = 223/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 17 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 68
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG
Sbjct: 69 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGM 126
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 127 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 182
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L + F ++ ++FP+L P + +K ++RE++
Sbjct: 183 KFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 240
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 241 HQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 299
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 300 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 359
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 360 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGLFLDKNGNFKKSDYFMPFS 419
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 420 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 451
>AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1
protein.
Length = 493
Score = 195 bits (475), Expect = 3e-49
Identities = 139/481 (28%), Positives = 230/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLYVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKAIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+VHE R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 194 bits (473), Expect = 6e-49
Identities = 129/479 (26%), Positives = 230/479 (48%), Gaps = 22/479 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F N + +++ G R++ D +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKG----ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLTYFP--GAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRALREHGEVNTYSE---GQLVAMCMDMFMAGTETTSKSMSFCFS 320
+ P KD +D Y+ + E + N +SE L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-KDLIDTYLLHMEEE-KSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFL 312
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH
Sbjct: 313 LMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
+ T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L
Sbjct: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG 432
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
K C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 433 KRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 194 bits (473), Expect = 6e-49
Identities = 131/452 (28%), Positives = 222/452 (49%), Gaps = 23/452 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
E+ KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG
Sbjct: 79 GYESVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF
Sbjct: 370 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 430 AGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
>AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13
variant 3 protein.
Length = 494
Score = 194 bits (472), Expect = 8e-49
Identities = 135/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13
variant 2 protein.
Length = 494
Score = 194 bits (472), Expect = 8e-49
Identities = 135/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13
variant 1 protein.
Length = 494
Score = 194 bits (472), Expect = 8e-49
Identities = 135/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13
protein.
Length = 494
Score = 194 bits (472), Expect = 8e-49
Identities = 135/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 193 bits (471), Expect = 1e-48
Identities = 127/480 (26%), Positives = 230/480 (47%), Gaps = 22/480 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREHGEV-NTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ ++ P + +D + ++ + G +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWG 316
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 LLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHM 376
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 TSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFS 436
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +PR
Sbjct: 437 AGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 496
>M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein.
Length = 462
Score = 193 bits (470), Expect = 1e-48
Identities = 131/449 (29%), Positives = 220/449 (48%), Gaps = 23/449 (5%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ + E
Sbjct: 2 PPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFHGYE 53
Query: 87 ANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
A KE L + E+ GR Q T G G++ ++G+ WKE RRF + L+ FG G+
Sbjct: 54 AVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGMGKR 111
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ + + EA H ++D + ++ N + +++ R++ D
Sbjct: 112 SIEDRVQEEA-HCLVDELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFL 167
Query: 205 ILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
L + F ++ ++FP+L P + +K ++RE++ H+
Sbjct: 168 TLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVREHQA 225
Query: 264 SFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 226 SLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLL 284
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 285 LLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTT 344
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
DT IP+ T +++ T++L D+ FP P F P FL NG D++ PF K
Sbjct: 345 DTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGK 404
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 405 RICAGEGLARMELFLFLTTILQNFNLKSV 433
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 193 bits (470), Expect = 1e-48
Identities = 126/478 (26%), Positives = 229/478 (47%), Gaps = 20/478 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A H+ N + +++ G R++ D +
Sbjct: 141 SVEERTQEEAQCLIEELRKSKGALMDATFLFHSI----TANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNPQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRAL-REHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P +D +D Y+ + +E ++ +S L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-RDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ 373
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L K
Sbjct: 374 HTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 192 bits (469), Expect = 2e-48
Identities = 127/478 (26%), Positives = 230/478 (48%), Gaps = 20/478 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F N + +++ G R++ D +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKG----ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRAL-REHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P KD +D Y+ + +E ++ +S L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ 373
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L K
Sbjct: 374 HTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 192 bits (469), Expect = 2e-48
Identities = 127/478 (26%), Positives = 230/478 (48%), Gaps = 20/478 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F N + +++ G R++ D +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKG----ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRAL-REHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P KD +D Y+ + +E ++ +S L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ 373
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L K
Sbjct: 374 HTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6
protein.
Length = 500
Score = 192 bits (469), Expect = 2e-48
Identities = 127/481 (26%), Positives = 232/481 (48%), Gaps = 20/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + G R + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSG-RPFRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 202
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 203 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 259
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 260 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 319
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 320 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 379
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 380 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 439
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 440 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 499
Query: 497 R 497
R
Sbjct: 500 R 500
>AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13
variant 6 protein.
Length = 494
Score = 192 bits (469), Expect = 2e-48
Identities = 134/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ E++ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPELEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 192 bits (469), Expect = 2e-48
Identities = 127/478 (26%), Positives = 230/478 (48%), Gaps = 20/478 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F N + +++ G R++ D +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKG----ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRAL-REHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P KD +D Y+ + +E ++ +S L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ 373
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L K
Sbjct: 374 HTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13
variant 5 protein.
Length = 494
Score = 192 bits (468), Expect = 2e-48
Identities = 134/446 (30%), Positives = 222/446 (49%), Gaps = 23/446 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + I+ + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IEALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 -MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
+ +L+ ML G + F S++ + K + + F+ +++ +
Sbjct: 198 FLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRF 464
K C G+ LA+ +F+F TT++Q F
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNF 460
>BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 192 bits (467), Expect = 3e-48
Identities = 138/481 (28%), Positives = 229/481 (47%), Gaps = 31/481 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP PI+G +++L K + K+ L+ + PV L +G R+V+++ +
Sbjct: 33 PPGPFPLPIIG---NLFQLELKN--IPKSFTRLAQRF---GPVFTLCVGSQRMVVMHGYK 84
Query: 87 ANKEML--FNEDIDGRPK-GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGR 143
A KE L + ++ GR F+ R RG++ +G WK+ RRF + L+ +G G+
Sbjct: 85 AVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140
Query: 144 SGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQM 203
G + EA H +++ + +G N + ++ ++ +D +
Sbjct: 141 QGNESRIQREA-HFLLEALRKT--QGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKF 196
Query: 204 KILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHK 262
L + + F + +++FP P +R IK + +++ E + H
Sbjct: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHH 254
Query: 263 DSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFS 320
S P+ +D D + + + H Y+ + D+F AGTETTS ++ +
Sbjct: 255 QSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313
Query: 321 YLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL 380
L++ E++ K EEIDRV+G R+P++ DR MPY +A+V E R +PH A
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVREIQRFITLVPSNLPHEAT 373
Query: 381 RDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLA 439
RDT G IP+ T+VV ++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433
Query: 440 KHRCMGDALAKCNIFVFTTTMLQRFSLVPV--PGEGLPSLDHMD-GATPSAAPFKALVIP 496
K C G+ LA+ +F+ +LQ F+L P+ P + S H+ G P +K VIP
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR--YKLCVIP 491
Query: 497 R 497
R
Sbjct: 492 R 492
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 192 bits (467), Expect = 3e-48
Identities = 126/478 (26%), Positives = 231/478 (48%), Gaps = 20/478 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ PPGP+ P+LG ++ ++ G L +R K V + +G +VM+
Sbjct: 29 RLPPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+EA +E L ++ +G + GV+ +G WK RRF + +++FG G+
Sbjct: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F+ N + +++ G R++ D +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKG----ALMDPTFLFHSITANIICSIVFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMV-GTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+ ++ + F+ + V G F F P +R K + I ++ + +H++
Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRAL-REHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P +D +D Y+ + +E ++ +S L + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-RDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + EI++V+G R P ++DR MPY EA+++E R GVPH +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ 373
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
T+ G IP+DT V + L D +YF +P +F P+ FL NG + + + PF L K
Sbjct: 374 HTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLV-PVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
C+G+ +A+ +F+F TT+LQ FS+ PV E + G ++ +PR
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 190 bits (464), Expect = 7e-48
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTKEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 190 bits (463), Expect = 1e-47
Identities = 126/481 (26%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 190 bits (462), Expect = 1e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 189 bits (461), Expect = 2e-47
Identities = 137/447 (30%), Positives = 221/447 (49%), Gaps = 25/447 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A KE L + E+ GR + + G GV ++GE K+ RRF I L+ FG G
Sbjct: 84 HDAVKEALVDQAEEFSGRGEQATFDWLFKGY--GVAFSNGERAKQLRRFSIATLRGFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR--GTHG-ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSH-FPILSIVAPTLSG-YRNFIKTHKRIWKFLREELAR 260
L M+ F GT+ + + S V L G + K + + F+ +++
Sbjct: 198 FLSLLRMMLGRF---QFTGTSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEH 254
Query: 261 HKDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFC 318
++ + P+ +DF+D + IR E NT + LV +++F AGTET S ++ +
Sbjct: 255 NQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYG 313
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
F L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R G+ HR
Sbjct: 314 FLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHR 373
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
+DT +P+ T V + L D +F P P+ FL G+ D + PF
Sbjct: 374 VNKDTKFRDFFLPKGTEVFPMLGSELRDPRFFSNPQDCSPQHFLDEKGQFKKSDAFVPFS 433
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRF 464
+ K C G+ LA+ +F+F TT++Q F
Sbjct: 434 IGKRYCFGEGLARMELFLFFTTIMQNF 460
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 189 bits (460), Expect = 2e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R G+ H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 189 bits (460), Expect = 2e-47
Identities = 131/448 (29%), Positives = 223/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 189 bits (460), Expect = 2e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R G+ H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + S +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 189 bits (460), Expect = 2e-47
Identities = 125/481 (25%), Positives = 230/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF I L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSISTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID ++G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDMIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 189 bits (460), Expect = 2e-47
Identities = 131/448 (29%), Positives = 223/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 189 bits (460), Expect = 2e-47
Identities = 131/448 (29%), Positives = 223/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 189 bits (460), Expect = 2e-47
Identities = 131/448 (29%), Positives = 223/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 189 bits (460), Expect = 2e-47
Identities = 131/448 (29%), Positives = 223/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 188 bits (459), Expect = 3e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 188 bits (459), Expect = 3e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 188 bits (459), Expect = 3e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 188 bits (459), Expect = 3e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 188 bits (459), Expect = 3e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 188 bits (457), Expect = 5e-47
Identities = 124/481 (25%), Positives = 229/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++ PGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYSPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 188 bits (457), Expect = 5e-47
Identities = 123/446 (27%), Positives = 219/446 (49%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFFGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 187 bits (456), Expect = 7e-47
Identities = 131/448 (29%), Positives = 222/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDAHR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 187 bits (456), Expect = 7e-47
Identities = 131/448 (29%), Positives = 222/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEEAGFL-IDAHR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRNCFGEGLARMELFLFFTTVMQNFRL 462
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 186 bits (454), Expect = 1e-46
Identities = 130/448 (29%), Positives = 222/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 27 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 78
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RRF I L++FG G
Sbjct: 79 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVG 136
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + EA + ID + G A I F + + N + +++ G+R++ D +
Sbjct: 137 KRGIEERIQEEAGFL-IDALR---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 192
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++
Sbjct: 193 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHK 250
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + LV +++F+ GTET S ++ + F
Sbjct: 251 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGF 309
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ + EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 310 LLLMKHPEVEAQVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 369
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL G+ D + PF +
Sbjct: 370 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSI 429
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 430 GKRNCFGEGLARMELFLFFTTVMQNFRL 457
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 186 bits (453), Expect = 2e-46
Identities = 122/446 (27%), Positives = 218/446 (48%), Gaps = 19/446 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
D IP+ ++++ T++L ++ FP P F P FL +G D++ PF K
Sbjct: 373 DVKFKNYLIPKGMTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGK 432
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSL 466
CMG+ LA+ +F+F TT+LQ F+L
Sbjct: 433 RMCMGEGLARMELFLFLTTILQNFNL 458
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 186 bits (452), Expect = 2e-46
Identities = 124/481 (25%), Positives = 229/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++ PGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYSPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 186 bits (452), Expect = 2e-46
Identities = 124/481 (25%), Positives = 229/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++ PGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYSPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 186 bits (452), Expect = 2e-46
Identities = 124/481 (25%), Positives = 229/481 (47%), Gaps = 23/481 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++ PGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYSPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E L ED RP Q +G R +GV L G W+EQRRF + L+ G
Sbjct: 84 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + + + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + D+F AG TTS ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 316
Query: 318 CFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPH 377
++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R GV H
Sbjct: 317 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 376
Query: 378 RALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
RD + G IP+ T +++N +++L DE + +P+ F PE FL G P+ + PF
Sbjct: 377 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436
Query: 437 GLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F+F T++LQ FS G+ PS + + +P++ +P
Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVP 496
Query: 497 R 497
R
Sbjct: 497 R 497
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 15 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 66
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 67 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 124
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 125 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 180
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 181 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 237
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 238 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 296
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 297 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 356
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 357 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 416
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 417 AGKRICVGEALAGMELFLFLTSILQNFNL 445
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 25 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 76
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 77 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 134
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 135 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 190
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 191 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 247
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 248 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 306
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 307 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 366
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 367 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 426
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 427 AGKRICVGEALAGMELFLFLTSILQNFNL 455
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 28 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 251 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 430 AGKRICVGEALAGMELFLFLTSILQNFNL 458
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 28 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 251 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 430 AGKRICVGEALAGMELFLFLTSILQNFNL 458
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 28 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 251 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 430 AGKRICVGEALAGMELFLFLTSILQNFNL 458
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 185 bits (451), Expect = 3e-46
Identities = 128/449 (28%), Positives = 216/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 28 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 251 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 430 AGKRICVGEALAGMELFLFLTSILQNFNL 458
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 183 bits (446), Expect = 1e-45
Identities = 128/449 (28%), Positives = 215/449 (47%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 23 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 74
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 75 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 132
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 133 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 188
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 189 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 245
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 246 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 304
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R +PH
Sbjct: 305 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHA 364
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 365 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFS 424
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 425 AGKRICVGEALAGMELFLFLTSILQNFNL 453
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 183 bits (446), Expect = 1e-45
Identities = 128/449 (28%), Positives = 215/449 (47%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G + ++ K + K++ LS Y PV L G IV+++
Sbjct: 23 KLPPGPTPLPVIG---NILQIGIKD--ISKSLTNLSKVY---GPVFTLYFGLKPIVVLHG 74
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L + E+ GR GIF G++ ++G+ WKE RRF + L+ FG G
Sbjct: 75 YEAVKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 132
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 133 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFHKRFDYKDQQ 188
Query: 203 MKILQSMLFDLFAAVDM--VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L L + + + + PI+ T + +K + ++ E++
Sbjct: 189 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKE 245
Query: 261 HKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H++S + +DF+D ++ + + H + + ++ L +D+F AGTETTS ++ +
Sbjct: 246 HQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 304
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R +PH
Sbjct: 305 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHA 364
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFG 437
D IP+ T ++ + T++L D FP P F P FL G YF PF
Sbjct: 365 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFS 424
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ALA +F+F T++LQ F+L
Sbjct: 425 AGKRICVGEALAGMELFLFLTSILQNFNL 453
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 182 bits (442), Expect = 3e-45
Identities = 124/428 (28%), Positives = 215/428 (50%), Gaps = 18/428 (4%)
Query: 45 LREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFN--EDIDGRPK 102
L+ T +Y ++ ++S Y PV + +G R+V++ +A +E L + E+ GR +
Sbjct: 1 LQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGE 57
Query: 103 GIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVM 162
+ G GV+ ++GE K+ RRF I L++FG G+ G+ E + EA + ID +
Sbjct: 58 QATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFL-IDAL 114
Query: 163 HMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGT 222
G A I F + + N + +++ G+R++ D + L M+ +F +
Sbjct: 115 R---GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTST--S 169
Query: 223 AFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVY-IR 280
+ + S V L G + + + + F+ +++ ++ + P+ +DF+D + IR
Sbjct: 170 TGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSP-RDFIDSFLIR 228
Query: 281 ALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRV 339
E NT + LV +++F+ GTET S ++ + F L++ EV+ K EEIDRV
Sbjct: 229 MQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV 288
Query: 340 VGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSN 399
+GK+R P DR MPY EA++HE R + R +DT +P+ T V
Sbjct: 289 IGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPM 348
Query: 400 YTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTT 458
++L D ++F P F P+ FL G+ D + PF + K C G+ LA+ +F+F T
Sbjct: 349 LGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFT 408
Query: 459 TMLQRFSL 466
T++Q F L
Sbjct: 409 TVMQNFRL 416
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 181 bits (440), Expect = 6e-45
Identities = 128/449 (28%), Positives = 224/449 (49%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T ++ ++ + S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEHICDSIMKFSECY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV ++GE K+ RF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVAFSNGERAKQLLRFAIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + E+ ++ + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEESGFLIEAIRSSHG----ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L SM+ +F + + + S V L G + K + + F+ +++ +
Sbjct: 198 FLSLLSMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCM---DMFMAGTETTSKSMSFC 318
+ + P+ +DF+D ++ ++E E N +E L + M ++F+AGTET S ++ +
Sbjct: 256 QRTLDPNSP-QDFIDSFLIHMQEE-EKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYG 313
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
F L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 314 FLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARR 373
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVN-GRVSLPDHYFPFG 437
+DT +P+ T V ++L D ++F P F P+ FL + G+ D + PF
Sbjct: 374 VKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFS 433
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
+ K C G+ LA+ +F+F TT++Q F L
Sbjct: 434 IGKRYCFGEGLARMELFLFFTTVMQNFRL 462
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 179 bits (436), Expect = 2e-44
Identities = 127/448 (28%), Positives = 221/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T ++ ++ + S Y PV + +G R V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEHICDSIMKFSECY---GPVFTIHLGPRRAVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV ++GE K+ RF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVAFSNGERAKQLLRFAIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + E+ ++ + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEESGFLIEAIRSTHG----ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L S++ +F + + + S V L G + K + + F+ +++ +
Sbjct: 198 FLSLLSVMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + L+ +++F+AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVN-GRVSLPDHYFPFGL 438
+DT +P+ T V ++L D ++F P F P+ FL + G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 GKRYCFGEGLARMELFLFFTTVMQNFRL 462
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 179 bits (436), Expect = 2e-44
Identities = 125/448 (27%), Positives = 215/448 (47%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G ++ +++ + K++ LS Y PV L G +R+V+++
Sbjct: 28 KLPPGPTPLPVIGNILQI-DIKDVS----KSLTNLSKIY---GPVFTLYFGLERMVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
E KE L + E+ GR G F G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFQKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L L + V ++FP + P + +K + + E++ H
Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP--GTHNKLLKNLAFMESDILEKVKEH 251
Query: 262 KDSFQPDKEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
++S + +DF+D ++ + + + + ++ LV D+ AGTETTS ++ +
Sbjct: 252 QESMDIN-NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV K QEEI+RVVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGL 438
D IP+ T ++++ T++L D FP P F P FL G +YF PF
Sbjct: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 431 GKRICVGEGLARMELFLFLTFILQNFNL 458
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 179 bits (436), Expect = 2e-44
Identities = 125/448 (27%), Positives = 215/448 (47%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G ++ +++ + K++ LS Y PV L G +R+V+++
Sbjct: 28 KLPPGPTPLPVIGNILQI-DIKDVS----KSLTNLSKIY---GPVFTLYFGLERMVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
E KE L + E+ GR G F G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFQKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L L + V ++FP + P + +K + + E++ H
Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP--GTHNKLLKNLAFMESDILEKVKEH 251
Query: 262 KDSFQPDKEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
++S + +DF+D ++ + + + + ++ LV D+ AGTETTS ++ +
Sbjct: 252 QESMDIN-NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV K QEEI+RVVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGL 438
D IP+ T ++++ T++L D FP P F P FL G +YF PF
Sbjct: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 431 GKRICVGEGLARMELFLFLTFILQNFNL 458
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 179 bits (436), Expect = 2e-44
Identities = 125/448 (27%), Positives = 215/448 (47%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G ++ +++ + K++ LS Y PV L G +R+V+++
Sbjct: 28 KLPPGPTPLPVIGNILQI-DIKDVS----KSLTNLSKIY---GPVFTLYFGLERMVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
E KE L + E+ GR G F G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFQKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L L + V ++FP + P + +K + + E++ H
Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP--GTHNKLLKNLAFMESDILEKVKEH 251
Query: 262 KDSFQPDKEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
++S + +DF+D ++ + + + + ++ LV D+ AGTETTS ++ +
Sbjct: 252 QESMDIN-NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV K QEEI+RVVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGL 438
D IP+ T ++++ T++L D FP P F P FL G +YF PF
Sbjct: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 431 GKRICVGEGLARMELFLFLTFILQNFNL 458
>U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 179 bits (435), Expect = 2e-44
Identities = 128/449 (28%), Positives = 220/449 (48%), Gaps = 25/449 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T ++ ++ + S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEHICDSIMKFSECY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + ++ G GV ++GE K+ RF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFEWVFKGY--GVAFSNGERAKQLLRFAIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + E+ ++ + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEESGFLIEAIRSTHG----ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKE 197
Query: 203 MKILQSMLFDLFAAVDM-VGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L SM+ +F G + F L P + K + F+ +++ +
Sbjct: 198 FLSLLSMMLGIFQFTSTSTGQLYEMFSSLMKHLP--GPQQQAFKLLLGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCM---DMFMAGTETTSKSMSFC 318
+ + P+ +DF+D ++ ++E E N +E L + M ++F+AGTET S ++ +
Sbjct: 256 QRTLDPNSP-QDFIDSFLIHMQEE-EKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYG 313
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
F L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 314 FLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARR 373
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
+DT +P+ T V ++L D +F P F P+ FL G+ D + PF
Sbjct: 374 VKKDTKFRDFFLPKGTEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFS 433
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
+ K C G+ LA+ +F+F TT++Q F L
Sbjct: 434 IRKRNCFGEGLARMELFLFFTTVMQNFRL 462
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 179 bits (435), Expect = 2e-44
Identities = 124/448 (27%), Positives = 215/448 (47%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P++G ++ +++ + K++ LS Y PV L G +R+V+++
Sbjct: 28 KLPPGPTPLPVIGNILQI-DIKDVS----KSLTNLSKIY---GPVFTLYFGLERMVVLHG 79
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
E KE L + E+ GR G F G++ ++G+ WKE RRF + L+ FG G
Sbjct: 80 YEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ + + + EA +V ++ N + +++ R++ D Q
Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCNVICSIIFQKRFDYKDQQ 193
Query: 203 MKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L L + V ++FP + P + +K + + E++ H
Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP--GTHNKLLKNLAFMESDILEKVKEH 251
Query: 262 KDSFQPDKEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
++S + +DF+D ++ + + + + ++ LV D+ AGTETTS ++ +
Sbjct: 252 QESMDIN-NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 311 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGL 438
D IP+ T ++++ T++L D FP P F P FL G +YF PF
Sbjct: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 431 GKRICVGEGLARMELFLFLTFILQNFNL 458
>U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 178 bits (434), Expect = 3e-44
Identities = 126/448 (28%), Positives = 220/448 (49%), Gaps = 23/448 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP P +G L+ T +Y ++ ++S Y PV + +G R+V++
Sbjct: 32 KLPPGPTPLPFIG-----NYLQLNTEQMYNSLMKISERY---GPVFTIHLGPRRVVVLCG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
+A +E L + E+ GR + + G GV+ ++GE K+ RF I L++FG G
Sbjct: 84 HDAVREALVDQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLLRFAIATLRDFGVG 141
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
+ G+ E + E+ ++ + G A I F + + N + +++ G+R++ D +
Sbjct: 142 KRGIEERIQEESGFLIEAIRSTHG----ANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE 197
Query: 203 MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARH 261
L M+ +F + + + S V L G + + + + F+ +++ +
Sbjct: 198 FLSLLRMMLGIFQFTST--STGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255
Query: 262 KDSFQPDKEDKDFMDVY-IRALREHGEVNT-YSEGQLVAMCMDMFMAGTETTSKSMSFCF 319
+ + P+ +DF+D + IR E NT + L+ +++F+AGTET S ++ + F
Sbjct: 256 QRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLHYGF 314
Query: 320 SYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRA 379
L++ EV+ K EEIDRV+GK+R P DR MPY EA++HE R + R
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 374
Query: 380 LRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGL 438
+DT +P+ V ++L D +F P F P+ FL G+ D + PF +
Sbjct: 375 KKDTKFRDFFLPKGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSI 434
Query: 439 AKHRCMGDALAKCNIFVFTTTMLQRFSL 466
K C G+ LA+ +F+F TT++Q F L
Sbjct: 435 RKRNCFGEGLARMELFLFFTTVMQNFRL 462
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 177 bits (431), Expect = 7e-44
Identities = 116/437 (26%), Positives = 211/437 (48%), Gaps = 16/437 (3%)
Query: 69 VLGLRIGKDRIVMVNSLEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GEL 124
V L++ +V++N L A +E + ED RP Q +G R +GV L G
Sbjct: 138 VFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 197
Query: 125 WKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYIL 184
W+EQRRF + L+ G G+ + + EA + + + + NV
Sbjct: 198 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSDAPFAPTVSWTKPSNV--- 254
Query: 185 NTLWTMMAGNRYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNF 243
+ ++ G R+ DP+ +++L L + + P+L + P L+G
Sbjct: 255 --IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVL-LHIPALAG--KV 309
Query: 244 IKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR--EHGEVNTYSEGQLVAMCM 301
++ K L E L H+ ++ P + +D + ++ + + +++++ L +
Sbjct: 310 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 369
Query: 302 DMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIV 361
D+F AG TTS ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++
Sbjct: 370 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 429
Query: 362 HECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERF 421
HE R GV H RD + G IP+ T +++N +++L DE + +P+ F PE F
Sbjct: 430 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 489
Query: 422 L-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHM 480
L G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS +
Sbjct: 490 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 549
Query: 481 DGATPSAAPFKALVIPR 497
+ +P++ +PR
Sbjct: 550 FAFLVTPSPYELCAVPR 566
>BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family 2,
subfamily W, polypeptide 1 protein.
Length = 490
Score = 175 bits (426), Expect = 3e-43
Identities = 126/458 (27%), Positives = 217/458 (47%), Gaps = 23/458 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP+ P++G + +L ++ +++ ELS Y PV + +G+ + V++
Sbjct: 30 RWPPGPRPLPLVGNL-HLLRLSQQD----RSLMELSERY---GPVFTVHLGRQKTVVLTG 81
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFG 142
EA KE L +++ RP +Q G G+ + G W+ R+F ++ L G G
Sbjct: 82 FEAVKEALAGPGQELADRPPIAIFQLIQRGG--GIFFSSGARWRAARQFTVRALHSLGVG 139
Query: 143 RSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ 202
R + + E + + + G RG N + ++ G R++ DP
Sbjct: 140 REPVADKILQELKCLS---GQLDGYRGRPFPLA--LLGWAPSNITFALLFGRRFDYRDPV 194
Query: 203 MKILQSMLFDLFAAVDMVGTA-FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARH 261
L ++ ++ + G F+ +P L + L +R ++ + + LR L
Sbjct: 195 FVSLLGLIDEVMVLLGSPGLQLFNVYPWLGAL---LQLHRPVLRKIEEVRAILRTLLEAR 251
Query: 262 KDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P ++D I+ + ++E VA +DM MAGTETTS ++ +
Sbjct: 252 RPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALL 311
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+ R +VQ + QEE+DRV+G R P + D+ +PY A++HE V+ F+ VP
Sbjct: 312 MGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHE-VQRFITLLPHVPRCTAA 370
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAK 440
DT L G +P+ T V+ T++LLDE + P F P FL NG + + PF +
Sbjct: 371 DTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGR 430
Query: 441 HRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLD 478
C+G+ LA+ +F+ +LQR+ L+P PG SLD
Sbjct: 431 RVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLD 468
>AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein.
Length = 516
Score = 175 bits (425), Expect = 4e-43
Identities = 124/500 (24%), Positives = 234/500 (46%), Gaps = 42/500 (8%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++PPGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYPPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFNLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRPKGIFYQTRTWGER-RGVLLTD-GELWKEQRRFLIKHLKEFG 140
L A +E + ED RP YQ +G R +GV+L+ G W+EQRRF + L+ G
Sbjct: 84 LAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWREQRRFSVSTLRNLG 143
Query: 141 FGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSD 200
G+ + + EA + D+ + + + + N + ++ G R+ D
Sbjct: 144 LGKKSLEQWVTEEAACLCA----AFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 201 PQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
P+ +++L L + + P+L + P L+G ++ K L E L
Sbjct: 200 PRFLRLLDLAQEGLKEESGFLREVLNAVPVLPHI-PALAG--KVLRFQKAFLTQLDELLT 256
Query: 260 RHKDSFQPDKEDKDFMDVYI--RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSF 317
H+ ++ P + +D + ++ + + +++++ L + ++F+AG TT ++++
Sbjct: 257 EHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVGNLFLAGMVTTLTTLAW 316
Query: 318 CFSYLVREQEVQR-------------------KAQEEIDRVVGKDRVPSVNDRPNMPYNE 358
++ +VQR + Q+EID V+G+ R P + D+ +MPY
Sbjct: 317 GLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQVRRPEMGDQVHMPYTT 376
Query: 359 AIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKP 418
A++HE R GV H RD + G IP+ T +++N +++L DE + +P+ F P
Sbjct: 377 AVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP 436
Query: 419 ERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSL 477
E FL G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS
Sbjct: 437 EHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSH 496
Query: 478 DHMDGATPSAAPFKALVIPR 497
+ + +P++ +PR
Sbjct: 497 SRVVSFLVTPSPYELCAVPR 516
>AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2
protein.
Length = 516
Score = 174 bits (423), Expect = 7e-43
Identities = 131/464 (28%), Positives = 209/464 (45%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + M +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAMALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDVFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for
cytochrome P-3-450. ).
Length = 515
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein.
Length = 512
Score = 171 bits (417), Expect = 4e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein.
Length = 515
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein.
Length = 515
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 171 bits (417), Expect = 4e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 171 bits (417), Expect = 4e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein.
Length = 516
Score = 171 bits (417), Expect = 4e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein.
Length = 512
Score = 171 bits (417), Expect = 4e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 171 bits (416), Expect = 5e-42
Identities = 114/405 (28%), Positives = 194/405 (47%), Gaps = 15/405 (3%)
Query: 68 PVLGLRIGKDRIVMVNSLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELW 125
PV L G +R+V+++ E KE L + E+ GR G F G++ ++G+ W
Sbjct: 41 PVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRW 98
Query: 126 KEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILN 185
KE RRF + L+ FG G+ + + + EA +V ++ N
Sbjct: 99 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTF----ILGCAPCN 154
Query: 186 TLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFI 244
+ +++ R++ D Q L L + V ++FP + P + +
Sbjct: 155 VICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP--GTHNKLL 212
Query: 245 KTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMD 302
K + + E++ H++S + +DF+D ++ + + + + ++ LV D
Sbjct: 213 KNLAFMESDILEKVKEHQESMDIN-NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAAD 271
Query: 303 MFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVH 362
+ AGTETTS ++ + L++ EV K QEEI+RVVG++R P + DR +MPY +A+VH
Sbjct: 272 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 331
Query: 363 ECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL 422
E R+ +PH D IP+ T ++++ T++L D FP P F P FL
Sbjct: 332 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 391
Query: 423 VNGRVSLPDHYF-PFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
G +YF PF K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 392 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 436
>K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein.
Length = 512
Score = 171 bits (416), Expect = 5e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPAEFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQR 477
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 171 bits (416), Expect = 5e-42
Identities = 130/464 (28%), Positives = 208/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RIG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSPFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 171 bits (415), Expect = 6e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQR 477
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 171 bits (415), Expect = 6e-42
Identities = 98/380 (25%), Positives = 186/380 (48%), Gaps = 11/380 (2%)
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+EQRRF + L+ G G+ + + EA + + + + +
Sbjct: 1 GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCA----AFANHSGRPFRPNGLLDK 56
Query: 182 YILNTLWTMMAGNRYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGY 240
+ N + ++ G R+ DP+ +++L L + + P+L + P L+G
Sbjct: 57 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG- 114
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVA 298
++ K L E L H+ ++ P + +D + ++ + + +++++ L
Sbjct: 115 -KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRI 173
Query: 299 MCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNE 358
+ D+F AG TTS ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY
Sbjct: 174 VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTT 233
Query: 359 AIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKP 418
A++HE R GV H RD + G IP+ T +++N +++L DE + +P+ F P
Sbjct: 234 AVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP 293
Query: 419 ERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSL 477
E FL G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS
Sbjct: 294 EHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 353
Query: 478 DHMDGATPSAAPFKALVIPR 497
+ + +P++ +PR
Sbjct: 354 HGVFAFLVTPSPYELCAVPR 373
>J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein.
Length = 491
Score = 171 bits (415), Expect = 6e-42
Identities = 125/481 (25%), Positives = 224/481 (46%), Gaps = 26/481 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP+ ILG + T L K +E Y + +G R+V+++
Sbjct: 29 KLPPGPRPLSILGNLLLLCSQDMLTS-LTKLSKEYGSMYT-------VHLGPRRVVVLSG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+A KE L ++ + +G + + + G+ + G+ WK R+F I+ L+ FG G+
Sbjct: 81 YQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E E ++ DV G+ + + N + +++ G+R++ D ++
Sbjct: 141 SIEERILEEGSFLLADVRKTEGEPFDPTFVLSRS----VSNIICSVLFGSRFDYDDERLL 196
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIK-THKRIW---KFLREELAR 260
+ ++ D F ++ + + + I+ P +++ H+RI+ K LR+ +A
Sbjct: 197 TIIRLINDNF---QIMSSPWGE--LYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAH 251
Query: 261 HKDSFQPDKEDKDFMDVYIRALREHGE--VNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
Q +DF+ ++ + E E ++ + L+ ++ GT+T S ++
Sbjct: 252 SVHDHQASSP-RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHA 310
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
F L++ +VQ + QEEID VVG+ R+P++ DR MPY +A++HE R +PHR
Sbjct: 311 FLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHR 370
Query: 379 ALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFG 437
RDT G IP+ T V++ + D + F P F PE FL N + PF
Sbjct: 371 VTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFS 430
Query: 438 LAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG-EGLPSLDHMDGATPSAAPFKALVIP 496
+ C+G+ LA+ +F++ T +LQ FSL P+ E + G PF+ + P
Sbjct: 431 AGRRLCLGELLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRP 490
Query: 497 R 497
R
Sbjct: 491 R 491
>AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 171 bits (415), Expect = 6e-42
Identities = 127/458 (27%), Positives = 219/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWDWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ + +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1
protein.
Length = 495
Score = 170 bits (413), Expect = 1e-41
Identities = 125/485 (25%), Positives = 229/485 (47%), Gaps = 30/485 (6%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
K PPGP+ ILG + T L K +E Y + +G R+V+++
Sbjct: 29 KLPPGPRPLSILGNLLLLCSQDMLTS-LTKLSKEYGSMYT-------VHLGPRRVVVLSG 80
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
+A KE L ++ + +G + + + G+ + G+ WK R+F I+ L+ FG G+
Sbjct: 81 YQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E E ++ ++ G+ + + N + +++ G+R++ D ++
Sbjct: 141 SIEERILEEGSFLLAELRKTEGEPFDPTFVLSRS----VSNIICSVLFGSRFDYDDERLL 196
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIK-THKRIW---KFLREELAR 260
+ ++ D F ++ + + + I+ P +++ H+RI+ K LR+ +A
Sbjct: 197 TIIRLINDNF---QIMSSPWGE--LYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAH 251
Query: 261 ----HKDSFQPDKEDKDFMDVYIRALREHGE--VNTYSEGQLVAMCMDMFMAGTETTSKS 314
H+ S P + +DF+ ++ + E E ++ + L+ ++ GT+T S +
Sbjct: 252 SVHDHQASLDP-RSPRDFIHCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 310
Query: 315 MSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFG 374
+ F L++ +VQ + QEEID VVG+ R+P++ DR MPY +A++HE R
Sbjct: 311 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 370
Query: 375 VPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHY 433
+PHR RDT G IP+ T V++ + D + F P F PE FL N +
Sbjct: 371 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 430
Query: 434 FPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG-EGLPSLDHMDGATPSAAPFKA 492
PF + C+G++LA+ +F++ T +LQ FSL P+ E + G PF+
Sbjct: 431 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 490
Query: 493 LVIPR 497
+ PR
Sbjct: 491 CLRPR 495
>L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrome
P-450 4 gene, exon 7, and three Alu repeats in the 3'
flank. ).
Length = 516
Score = 169 bits (411), Expect = 2e-41
Identities = 129/464 (27%), Positives = 207/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL + IG +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQISIGSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 169 bits (410), Expect = 3e-41
Identities = 129/464 (27%), Positives = 207/464 (44%), Gaps = 28/464 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PP P P+LG V L + + A+ +S Y VL +RI +++
Sbjct: 37 KGLKSPPEPWGWPLLG---HVLTLGKNP---HLALSRMSQRY---GDVLQIRIDSTPVLV 87
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP T G+ G +W +RR L F
Sbjct: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
++ EH+ + +I G +N V + N + M G
Sbjct: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
+ S +M L + F G FPIL + P L ++ F + +W F
Sbjct: 208 HFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAF--NQRFLW-F 263
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETT 311
L++ + H F + +D + ++ N + ++V + D+F AG +T
Sbjct: 264 LQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
+ ++S+ YLV + E+QRK Q+E+D V+G++R P ++DRP +PY EA + E RH
Sbjct: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRV--- 427
F +PH RDTTL G +IP+ V N + D + +P F+PERFL +G
Sbjct: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442
Query: 428 SLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPG 471
L + FG+ K RC+G+ LAK IF+F +LQ+ PG
Sbjct: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 168 bits (409), Expect = 3e-41
Identities = 127/458 (27%), Positives = 217/458 (47%), Gaps = 31/458 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWDWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGN 194
T+ EH+ +I G + + V + N + + G
Sbjct: 146 SIASDPASSTSCYLEEHVSKGAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205
Query: 195 RYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKF 253
RY+ + ++ L + L + F V G PIL + P+L+ +++ +++ + F
Sbjct: 206 RYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSF 261
Query: 254 LREELARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGT 308
+++ + H +F+ +D D I + L E+ V S+ +++ + +D+F AG
Sbjct: 262 MQKMVKEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGF 319
Query: 309 ETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHF 368
+T + + S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH
Sbjct: 320 DTVTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRV 427
F +PH RDT+L G +IP+ V N I D+ + P F PERFL +G +
Sbjct: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERFLTPDGAI 439
Query: 428 S--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 164 bits (399), Expect = 6e-40
Identities = 114/433 (26%), Positives = 211/433 (48%), Gaps = 19/433 (4%)
Query: 74 IGKDRIVMVNSLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRR 130
IG +V+++ + +E L E RP+ T + +GV+ G +W++QR+
Sbjct: 122 IGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT--KEKGVVFAHYGPVWRQQRK 179
Query: 131 FLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTM 190
F L+ FG G+ + E +++ ++ G + + + N + ++
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQK----HGEDPFCPFSIISNAVSNIICSL 235
Query: 191 MAGNRYNPSDPQMK-ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKR 249
G R++ ++ + K +L M L ++ + P L + ++ + K
Sbjct: 236 CFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLP--FGPFKELRQIEKD 293
Query: 250 IWKFLREELARHKDSFQPDKED-KDFMDVYIRALREHGEVNT---YSEGQLVAMCMDMFM 305
I FL++ + H++S D+E+ +DF+D+Y+ + E + N+ + E L + D+F+
Sbjct: 294 ITSFLKKIIKDHQESL--DRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFI 351
Query: 306 AGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECV 365
AGT+TT+ S+ +C Y+ +VQ K EEI+RV+G +R PS+ D+ MPY EA + E
Sbjct: 352 AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQ 411
Query: 366 RHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVN- 424
R + +PH +T L G IP+ T+++ N ++ D + +P F P RFL +
Sbjct: 412 RLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQ 471
Query: 425 GRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGAT 484
G++ + + PFG+ K CMG+ LAK +F+ +++Q F+ P L G T
Sbjct: 472 GQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLT 531
Query: 485 PSAAPFKALVIPR 497
+ PF + R
Sbjct: 532 LAPHPFNITISRR 544
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 164 bits (399), Expect = 6e-40
Identities = 114/433 (26%), Positives = 211/433 (48%), Gaps = 19/433 (4%)
Query: 74 IGKDRIVMVNSLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRR 130
IG +V+++ + +E L E RP+ T + +GV+ G +W++QR+
Sbjct: 122 IGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT--KEKGVVFAHYGPVWRQQRK 179
Query: 131 FLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTM 190
F L+ FG G+ + E +++ ++ G + + + N + ++
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQK----HGEDPFCPFSIISNAVSNIICSL 235
Query: 191 MAGNRYNPSDPQMK-ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKR 249
G R++ ++ + K +L M L ++ + P L + ++ + K
Sbjct: 236 CFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLP--FGPFKELRQIEKD 293
Query: 250 IWKFLREELARHKDSFQPDKED-KDFMDVYIRALREHGEVNT---YSEGQLVAMCMDMFM 305
I FL++ + H++S D+E+ +DF+D+Y+ + E + N+ + E L + D+F+
Sbjct: 294 ITSFLKKIIKDHQESL--DRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFI 351
Query: 306 AGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECV 365
AGT+TT+ S+ +C Y+ +VQ K EEI+RV+G +R PS+ D+ MPY EA + E
Sbjct: 352 AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQ 411
Query: 366 RHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVN- 424
R + +PH +T L G IP+ T+++ N ++ D + +P F P RFL +
Sbjct: 412 RLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQ 471
Query: 425 GRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGAT 484
G++ + + PFG+ K CMG+ LAK +F+ +++Q F+ P L G T
Sbjct: 472 GQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLT 531
Query: 485 PSAAPFKALVIPR 497
+ PF + R
Sbjct: 532 LAPHPFNITISRR 544
>BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family 2,
subfamily S, polypeptide 1 protein.
Length = 504
Score = 164 bits (398), Expect = 7e-40
Identities = 122/476 (25%), Positives = 216/476 (45%), Gaps = 20/476 (4%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDR-IVMVNSL 85
PPGP P+LG + +LR G LY + LS Y PV + +G R +V++
Sbjct: 33 PPGPTPLPLLG---NLLQLRP--GALYSGLMRLSKKY---GPVFTIYLGPWRPVVVLVGQ 84
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRSG 145
EA +E L + + +G + GV ++GE W++ R+F + L++ G G+
Sbjct: 85 EAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKRE 144
Query: 146 MGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK- 204
E + EA +V G + + + N + +++ G R++ D + +
Sbjct: 145 GEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS----NVVCSLLFGLRFSYEDKEFQA 200
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDS 264
++++ L G + F + P ++ + + F ++ +H+ +
Sbjct: 201 VVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGN 258
Query: 265 FQPDKEDKDFMDVYI--RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYL 322
+D +D ++ A E ++ ++ + + AGT T S ++ + L
Sbjct: 259 LDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLL 318
Query: 323 VREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRD 382
++ VQ+ +EE++R +G + PS+ DR +PY +A++HE R G+P +R
Sbjct: 319 MKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRT 378
Query: 383 TTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKH 441
T G +P+ T V +IL D N F P F P+RFL +GR + + PF L K
Sbjct: 379 TRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKR 438
Query: 442 RCMGDALAKCNIFVFTTTMLQRFSL-VPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
C+G+ LAK +F+F TT+LQ FSL P P + L + G F+ V P
Sbjct: 439 VCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein.
Length = 504
Score = 164 bits (398), Expect = 7e-40
Identities = 122/476 (25%), Positives = 216/476 (45%), Gaps = 20/476 (4%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDR-IVMVNSL 85
PPGP P+LG + +LR G LY + LS Y PV + +G R +V++
Sbjct: 33 PPGPTPLPLLG---NLLQLRP--GALYSGLMRLSKKY---GPVFTIYLGPWRPVVVLVGQ 84
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRSG 145
EA +E L + + +G + GV ++GE W++ R+F + L++ G G+
Sbjct: 85 EAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKRE 144
Query: 146 MGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK- 204
E + EA +V G + + + N + +++ G R++ D + +
Sbjct: 145 GEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS----NVVCSLLFGLRFSYEDKEFQA 200
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDS 264
++++ L G + F + P ++ + + F ++ +H+ +
Sbjct: 201 VVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGN 258
Query: 265 FQPDKEDKDFMDVYI--RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYL 322
+D +D ++ A E ++ ++ + + AGT T S ++ + L
Sbjct: 259 LDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLL 318
Query: 323 VREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRD 382
++ VQ+ +EE++R +G + PS+ DR +PY +A++HE R G+P +R
Sbjct: 319 MKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRT 378
Query: 383 TTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKH 441
T G +P+ T V +IL D N F P F P+RFL +GR + + PF L K
Sbjct: 379 TRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKR 438
Query: 442 RCMGDALAKCNIFVFTTTMLQRFSL-VPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
C+G+ LAK +F+F TT+LQ FSL P P + L + G F+ V P
Sbjct: 439 VCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1
protein.
Length = 504
Score = 164 bits (398), Expect = 7e-40
Identities = 122/476 (25%), Positives = 216/476 (45%), Gaps = 20/476 (4%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDR-IVMVNSL 85
PPGP P+LG + +LR G LY + LS Y PV + +G R +V++
Sbjct: 33 PPGPTPLPLLG---NLLQLRP--GALYSGLMRLSKKY---GPVFTIYLGPWRPVVVLVGQ 84
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRSG 145
EA +E L + + +G + GV ++GE W++ R+F + L++ G G+
Sbjct: 85 EAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKRE 144
Query: 146 MGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK- 204
E + EA +V G + + + N + +++ G R++ D + +
Sbjct: 145 GEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS----NVVCSLLFGLRFSYEDKEFQA 200
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDS 264
++++ L G + F + P ++ + + F ++ +H+ +
Sbjct: 201 VVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGN 258
Query: 265 FQPDKEDKDFMDVYI--RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYL 322
+D +D ++ A E ++ ++ + + AGT T S ++ + L
Sbjct: 259 LDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLL 318
Query: 323 VREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRD 382
++ VQ+ +EE++R +G + PS+ DR +PY +A++HE R G+P +R
Sbjct: 319 MKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRT 378
Query: 383 TTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKH 441
T G +P+ T V +IL D N F P F P+RFL +GR + + PF L K
Sbjct: 379 TRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKR 438
Query: 442 RCMGDALAKCNIFVFTTTMLQRFSL-VPVPGEGLPSLDHMDGATPSAAPFKALVIP 496
C+G+ LAK +F+F TT+LQ FSL P P + L + G F+ V P
Sbjct: 439 VCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRP 494
>AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens
cDNA FLJ14699 fis, clone NT2RP2006571, moderately
similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
Length = 564
Score = 163 bits (397), Expect = 1e-39
Identities = 118/454 (25%), Positives = 210/454 (46%), Gaps = 20/454 (4%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDR-IVMVNSL 85
PPGP P+LG + +LR G LY + LS Y PV + +G R +V++
Sbjct: 33 PPGPTPLPLLG---NLLQLRP--GALYSGLMRLSKKY---GPVFTIYLGPWRPVVVLVGQ 84
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRSG 145
EA +E L + + +G + GV ++GE W++ R+F + L++ G G+
Sbjct: 85 EAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKRE 144
Query: 146 MGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK- 204
E + EA +V G + + + N + +++ G R++ D + +
Sbjct: 145 GEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS----NVVCSLLFGLRFSYEDKEFQA 200
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDS 264
++++ L G + F + P ++ + + F ++ +H+ +
Sbjct: 201 VVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGN 258
Query: 265 FQPDKEDKDFMDVYI--RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYL 322
+D +D ++ A E ++ ++ + + AGT T S ++ + L
Sbjct: 259 LDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLL 318
Query: 323 VREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRD 382
++ VQ+ +EE++R +G + PS+ DR +PY +A++HE R G+P +R
Sbjct: 319 MKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRT 378
Query: 383 TTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKH 441
T G +P+ T V +IL D N F P F P+RFL +GR + + PF L K
Sbjct: 379 TRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKR 438
Query: 442 RCMGDALAKCNIFVFTTTMLQRFSL-VPVPGEGL 474
C+G+ LAK +F+F TT+LQ FSL P P + L
Sbjct: 439 VCLGEGLAKAELFLFFTTILQAFSLESPCPPDTL 472
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 163 bits (396), Expect = 1e-39
Identities = 120/487 (24%), Positives = 227/487 (46%), Gaps = 32/487 (6%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
++ PGP P+ G ++ + T Y + +R + V L++ +V++N
Sbjct: 32 RYSPGP--LPLPGLGNLLHVDFQNTPYCFDQLRR------RFGDVFSLQLAWTPVVVLNG 83
Query: 85 LEANKEMLFN--EDIDGRP-----KGIFYQTRTWGERRGVLLTDGELWKEQRR---FLIK 134
L A +E + ED RP + + + R+ G++RGV G LW R L
Sbjct: 84 LAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGKQRGV---PGALWARVARAEALLRL 140
Query: 135 HLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGN 194
HL + G G+ G + + + + + + + N + ++ G
Sbjct: 141 HLAQLGPGQEVAGAVGDRGGRLPLCRLRQPL----RRPFRPNGLLDKAVSNVIASLTCGR 196
Query: 195 RYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKF 253
R+ DP+ +++L L + + P+L + P L+G ++ K
Sbjct: 197 RFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG--KVLRFQKAFLTQ 253
Query: 254 LREELARHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETT 311
L E L H+ ++ P + +D + ++ + + +++++ L + D+F AG TT
Sbjct: 254 LDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTT 313
Query: 312 SKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGR 371
S ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY A++HE R
Sbjct: 314 STTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIV 373
Query: 372 TFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLP 430
GV H RD + G IP+ T +++N +++L DE + +P+ F PE FL G P
Sbjct: 374 PLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKP 433
Query: 431 DHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPF 490
+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS + + +P+
Sbjct: 434 EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPY 493
Query: 491 KALVIPR 497
+ +PR
Sbjct: 494 ELCAVPR 500
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 160 bits (388), Expect = 1e-38
Identities = 99/356 (27%), Positives = 173/356 (48%), Gaps = 13/356 (3%)
Query: 116 GVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQM 175
G++ ++G+ WKE RRF + L+ FG G+ + + + EA +V ++
Sbjct: 4 GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTF-- 61
Query: 176 HNFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDM--VGTAFSHFPILSIV 233
N + +++ R++ D Q L L + + + + PI+
Sbjct: 62 --ILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYF 119
Query: 234 APTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTY 291
T + +K + ++ E++ H++S + +DF+D ++ + + H + + +
Sbjct: 120 PGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEF 175
Query: 292 SEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDR 351
+ L +D+F AGTETTS ++ + L++ EV K QEEI+RV+G++R P + DR
Sbjct: 176 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 235
Query: 352 PNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFP 411
+MPY +A+VHE R +PH D IP+ T ++ + T++L D FP
Sbjct: 236 SHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 295
Query: 412 EPYSFKPERFLVNGRVSLPDHYF-PFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
P F P FL G YF PF K C+G+ALA +F+F T++LQ F+L
Sbjct: 296 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 351
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 159 bits (386), Expect = 2e-38
Identities = 126/481 (26%), Positives = 224/481 (46%), Gaps = 33/481 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P FPPGP P +G +Y L + + +R+ S Y + + L +G V+
Sbjct: 35 RPMGFPPGPPGLPFIG---NIYSLAASSELPHVYMRKQSQVYGE---IFSLDLGGISTVV 88
Query: 82 VNSLEANKEMLFNED--IDGRPKGIFYQTRTWGERRGVLLTD--GELWKEQRRFLIKHLK 137
+N + KE L ++ RP + T + G LL G W + RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMT---KMGGLLNSRYGRGWVDHRRLAVNSFR 145
Query: 138 EFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
FG+G+ E+ LE D + R Q+ + N ++ G R+
Sbjct: 146 YFGYGQKSF-ESKILEETKFFNDAIETYKGRPFDFKQL---ITNAVSNITNLIIFGERFT 201
Query: 198 PSDPQMKILQSMLFDLFAA-VDMVGTA----FSHFPILSIVAPTLSGYRNFIKTHKRIWK 252
D Q M+ +LF+ V++ +A ++ FP + I+ ++ + ++
Sbjct: 202 YEDTDF---QHMI-ELFSENVELAASASVFLYNAFPWIGILP--FGKHQQLFRNAAVVYD 255
Query: 253 FLREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTET 310
FL + + + +P + F+D Y+ + + + +T+S+ L+ ++ +AGTET
Sbjct: 256 FLSRLIEKASVNRKPQLP-QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
T+ + + ++ +Q + Q+EID ++G + PS +D+ MPY EA++HE +R
Sbjct: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSL 429
G+ H D + G IP+ T V++N ++ DE Y+ +P F PERFL +G +
Sbjct: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434
Query: 430 PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAP 489
+ PF L + C+G+ LA+ +F+F T +LQRF L P E +P L G T P
Sbjct: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL-HFPHELVPDLKPRLGMTLQPQP 493
Query: 490 F 490
+
Sbjct: 494 Y 494
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 159 bits (386), Expect = 2e-38
Identities = 126/481 (26%), Positives = 224/481 (46%), Gaps = 33/481 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P FPPGP P +G +Y L + + +R+ S Y + + L +G V+
Sbjct: 35 RPMGFPPGPPGLPFIG---NIYSLAASSELPHVYMRKQSQVYGE---IFSLDLGGISTVV 88
Query: 82 VNSLEANKEMLFNED--IDGRPKGIFYQTRTWGERRGVLLTD--GELWKEQRRFLIKHLK 137
+N + KE L ++ RP + T + G LL G W + RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMT---KMGGLLNSRYGRGWVDHRRLAVNSFR 145
Query: 138 EFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
FG+G+ E+ LE D + R Q+ + N ++ G R+
Sbjct: 146 YFGYGQKSF-ESKILEETKFFNDAIETYKGRPFDFKQL---ITNAVSNITNLIIFGERFT 201
Query: 198 PSDPQMKILQSMLFDLFAA-VDMVGTA----FSHFPILSIVAPTLSGYRNFIKTHKRIWK 252
D Q M+ +LF+ V++ +A ++ FP + I+ ++ + ++
Sbjct: 202 YEDTDF---QHMI-ELFSENVELAASASVFLYNAFPWIGILP--FGKHQQLFRNAAVVYD 255
Query: 253 FLREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTET 310
FL + + + +P + F+D Y+ + + + +T+S+ L+ ++ +AGTET
Sbjct: 256 FLSRLIEKASVNRKPQLP-QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
T+ + + ++ +Q + Q+EID ++G + PS +D+ MPY EA++HE +R
Sbjct: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSL 429
G+ H D + G IP+ T V++N ++ DE Y+ +P F PERFL +G +
Sbjct: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434
Query: 430 PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAP 489
+ PF L + C+G+ LA+ +F+F T +LQRF L P E +P L G T P
Sbjct: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL-HFPHELVPDLKPRLGMTLQPQP 493
Query: 490 F 490
+
Sbjct: 494 Y 494
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 159 bits (386), Expect = 2e-38
Identities = 126/481 (26%), Positives = 224/481 (46%), Gaps = 33/481 (6%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P FPPGP P +G +Y L + + +R+ S Y + + L +G V+
Sbjct: 35 RPMGFPPGPPGLPFIG---NIYSLAASSELPHVYMRKQSQVYGE---IFSLDLGGISTVV 88
Query: 82 VNSLEANKEMLFNED--IDGRPKGIFYQTRTWGERRGVLLTD--GELWKEQRRFLIKHLK 137
+N + KE L ++ RP + T + G LL G W + RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMT---KMGGLLNSRYGRGWVDHRRLAVNSFR 145
Query: 138 EFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
FG+G+ E+ LE D + R Q+ + N ++ G R+
Sbjct: 146 YFGYGQKSF-ESKILEETKFFNDAIETYKGRPFDFKQL---ITNAVSNITNLIIFGERFT 201
Query: 198 PSDPQMKILQSMLFDLFAA-VDMVGTA----FSHFPILSIVAPTLSGYRNFIKTHKRIWK 252
D Q M+ +LF+ V++ +A ++ FP + I+ ++ + ++
Sbjct: 202 YEDTDF---QHMI-ELFSENVELAASASVFLYNAFPWIGILP--FGKHQQLFRNAAVVYD 255
Query: 253 FLREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTET 310
FL + + + +P + F+D Y+ + + + +T+S+ L+ ++ +AGTET
Sbjct: 256 FLSRLIEKASVNRKPQLP-QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
T+ + + ++ +Q + Q+EID ++G + PS +D+ MPY EA++HE +R
Sbjct: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSL 429
G+ H D + G IP+ T V++N ++ DE Y+ +P F PERFL +G +
Sbjct: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434
Query: 430 PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAP 489
+ PF L + C+G+ LA+ +F+F T +LQRF L P E +P L G T P
Sbjct: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL-HFPHELVPDLKPRLGMTLQPQP 493
Query: 490 F 490
+
Sbjct: 494 Y 494
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 157 bits (381), Expect = 8e-38
Identities = 97/344 (28%), Positives = 167/344 (48%), Gaps = 9/344 (2%)
Query: 126 KEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILN 185
KE RRF + L+ FG G+ + + + EA +V + + ++ N
Sbjct: 1 KEIRRFCLITLRNFGMGKRSIEDRVQEEARCLVEE----LRKTNASPCDPTFILGCAPCN 56
Query: 186 TLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIK 245
+ +++ R++ D Q L L + V + +I+ + +K
Sbjct: 57 VICSIIFHKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN-NFSTIIDYFPGSHNKLLK 115
Query: 246 THKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDM 303
+ ++ E + H++S + +DF+D ++ + + H + + ++ L+A DM
Sbjct: 116 NLLTLKSYVLERIKEHQESLDMN-NPRDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDM 174
Query: 304 FMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHE 363
F AGTETTS ++ + L++ EV K QEEI+RVVG++R P + DR +MPY +A+VHE
Sbjct: 175 FGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRSHMPYTDAVVHE 234
Query: 364 CVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV 423
R+ +PH D IP+ T ++++ T++L D FP P F P FL
Sbjct: 235 VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLD 294
Query: 424 NGRVSLPDHYF-PFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
G +YF PF K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 295 EGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 338
>BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein.
Length = 443
Score = 157 bits (380), Expect = 1e-37
Identities = 109/416 (26%), Positives = 199/416 (47%), Gaps = 19/416 (4%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQ-M 203
+ + + EA +V ++ ++ N + +++ +R++ D + +
Sbjct: 140 SIEDRVQEEARCLVEELRKT----NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFL 195
Query: 204 KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKD 263
+++ +L ++FP L P + + I ++ E + H++
Sbjct: 196 NLMEKFNENLRILSSPWIQVCNNFPALIDYLP--GSHNKIAENFAYIKSYVLERIKEHQE 253
Query: 264 SFQPDKEDKDFMDVYIRALRE--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
S + +DF+D ++ + + H + + ++ L+A DMF AGTETTS ++ +
Sbjct: 254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLL 312
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
L++ EV K QEEI+ VVG++R P + DR +MPY +A+VHE R+ +PH
Sbjct: 313 LLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC 372
Query: 382 DTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
D IP+ T ++++ T++L ++ FP P F P FL +G D++ PF
Sbjct: 373 DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPF 428
>CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein.
Length = 446
Score = 155 bits (377), Expect = 3e-37
Identities = 86/319 (26%), Positives = 163/319 (51%), Gaps = 7/319 (2%)
Query: 183 ILNTLWTMMAGNRYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYR 241
+ N + ++ G R+ DP+ +++L L + + P+L + P L+G
Sbjct: 131 VSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG-- 187
Query: 242 NFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAM 299
++ K L E L H+ ++ P + +D + ++ + + +++++ L +
Sbjct: 188 KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIV 247
Query: 300 CMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEA 359
D+F AG TTS ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY A
Sbjct: 248 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 307
Query: 360 IVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPE 419
++HE R GV H RD + G IP+ T +++N +++L DE + +P+ F PE
Sbjct: 308 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPE 367
Query: 420 RFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLD 478
FL G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS
Sbjct: 368 HFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHH 427
Query: 479 HMDGATPSAAPFKALVIPR 497
+ + +P++ +PR
Sbjct: 428 GVFAFLVTPSPYELCAVPR 446
>BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 446
Score = 155 bits (377), Expect = 3e-37
Identities = 86/319 (26%), Positives = 163/319 (51%), Gaps = 7/319 (2%)
Query: 183 ILNTLWTMMAGNRYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYR 241
+ N + ++ G R+ DP+ +++L L + + P+L + P L+G
Sbjct: 131 VSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG-- 187
Query: 242 NFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAM 299
++ K L E L H+ ++ P + +D + ++ + + +++++ L +
Sbjct: 188 KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIV 247
Query: 300 CMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEA 359
D+F AG TTS ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY A
Sbjct: 248 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 307
Query: 360 IVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPE 419
++HE R GV H RD + G IP+ T +++N +++L DE + +P+ F PE
Sbjct: 308 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPE 367
Query: 420 RFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLD 478
FL G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS
Sbjct: 368 HFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHH 427
Query: 479 HMDGATPSAAPFKALVIPR 497
+ + +P++ +PR
Sbjct: 428 GVFAFLVTPSPYELCAVPR 446
>BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein.
Length = 446
Score = 155 bits (377), Expect = 3e-37
Identities = 86/319 (26%), Positives = 163/319 (51%), Gaps = 7/319 (2%)
Query: 183 ILNTLWTMMAGNRYNPSDPQ-MKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYR 241
+ N + ++ G R+ DP+ +++L L + + P+L + P L+G
Sbjct: 131 VSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAG-- 187
Query: 242 NFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAM 299
++ K L E L H+ ++ P + +D + ++ + + +++++ L +
Sbjct: 188 KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIV 247
Query: 300 CMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEA 359
D+F AG TTS ++++ ++ +VQR+ Q+EID V+G+ R P + D+ +MPY A
Sbjct: 248 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 307
Query: 360 IVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPE 419
++HE R GV H RD + G IP+ T +++N +++L DE + +P+ F PE
Sbjct: 308 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPE 367
Query: 420 RFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLD 478
FL G P+ + PF + C+G+ LA+ +F+F T++LQ FS G+ PS
Sbjct: 368 HFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHH 427
Query: 479 HMDGATPSAAPFKALVIPR 497
+ + +P++ +PR
Sbjct: 428 GVFAFLVTPSPYELCAVPR 446
>BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 152 bits (368), Expect = 3e-36
Identities = 127/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G +S
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLISK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1
variant protein.
Length = 484
Score = 152 bits (368), Expect = 3e-36
Identities = 124/452 (27%), Positives = 216/452 (47%), Gaps = 47/452 (10%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
K K PPGP P++G + K +L A+ +S Y VL +RIG +V+
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVV 85
Query: 82 VNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEF 139
++ L+ ++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145
Query: 140 GFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPS 199
T+ EH+ + + V+ ++TL +MAG +
Sbjct: 146 SIASDPASSTSCYLEEHV---------SKEAEVL----------ISTLQELMAGPGH--F 184
Query: 200 DPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELA 259
+P ++ S+ + A +H +LS+V L+ +++ +++ + F+++ +
Sbjct: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV--NLNAFKDL---NEKFYSFMQKMVK 239
Query: 260 RHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKS 314
H +F+ +D D I + L E+ V S+ +++ + +D+F AG +T + +
Sbjct: 240 EHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTA 297
Query: 315 MSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFG 374
+S+ YLV VQRK QEE+D V+G+ R P ++DR ++PY EA + E RH F
Sbjct: 298 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 357
Query: 375 VPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRVS--LPD 431
+PH RDT+L G +IP+ V N I D+ + P F PERFL +G + L +
Sbjct: 358 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 417
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 418 KVIIFGMGKRKCIGETIARWEVFLFLAILLQR 449
>U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochrome
P450 protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1
protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein.
Length = 543
Score = 151 bits (365), Expect = 7e-36
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 150 bits (363), Expect = 1e-35
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 30/490 (6%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
R PPGP P++G A V + + + L+ Y V +R+G IV++N
Sbjct: 48 RSAPPGPFAWPLIGNAAAVGQAA------HLSFARLARRY---GDVFQIRLGSCPIVVLN 98
Query: 84 SLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTD-GELWKEQRRFLIKHLKEFGFG 142
A + L + + F R R + E WK QRR ++ F F
Sbjct: 99 GERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNF-FT 157
Query: 143 RSGMGETAKLEAEHIVIDVMHMI-----GDRGSAVIQMHNFFNVYILNTLWTMMAGNRYN 197
R LE H++ + ++ G A + V + N + + G RY+
Sbjct: 158 RQPRSRQV-LEG-HVLSEARELVALLVRGSADGAFLDPRPLTVVAMANVMSAVCFGCRYS 215
Query: 198 PSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLRE 256
DP+ + L S + V G+ P L P + +R F + ++ F+ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSSFILD 274
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEG------QLVAMCMDMFMAGTET 310
+ RH +S +P +D MD +I + + +++ G + A D+F A +T
Sbjct: 275 KFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT 334
Query: 311 TSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMG 370
S ++ + R +VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R
Sbjct: 335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSF 394
Query: 371 RTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS- 428
+PH +T++ G HIP+DT+V N ++ D +P P +F P RFL +G ++
Sbjct: 395 VPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINK 454
Query: 429 -LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSA 487
L F + K RC+G+ L+K +F+F + + + P E ++ G T
Sbjct: 455 DLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKP 513
Query: 488 APFKALVIPR 497
FK V R
Sbjct: 514 KSFKVNVTLR 523
>AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450
epoxygenase protein.
Length = 339
Score = 150 bits (363), Expect = 1e-35
Identities = 91/345 (26%), Positives = 167/345 (48%), Gaps = 18/345 (5%)
Query: 22 KPRKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVM 81
+P+ +PPGP P LG + + + +L E+ L K + L +G V+
Sbjct: 8 RPKNYPPGPWRLPFLG---NFFLVDFEQSHL-----EVQLFVKKYGNLFSLELGDISAVL 59
Query: 82 VNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
+ L KE L + D + + + ++ G++++ G+ WKEQRRF + L+ FG
Sbjct: 60 ITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGL 119
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ G+ E + EA+H+ I + H N + N + ++ G R+ D
Sbjct: 120 GKKGLEERIQEEAQHLT----EAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 175
Query: 202 QMKILQSMLFDL-FAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
+ L +L ++ + ++ FP + P ++ K++ F+ + +
Sbjct: 176 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP--GPHQTLFSNWKKLKLFVSHMIDK 233
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ + P E +DF+D Y++ + +H +++ E L+ +D+F AGTETTS ++ +
Sbjct: 234 HRKDWNP-AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWA 292
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHE 363
Y+ E+Q K Q EIDRV+G+ + PS R +MPY A++HE
Sbjct: 293 LLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARESMPYTNAVIHE 337
>X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120
AA) protein.
Length = 210
Score = 144 bits (349), Expect = 6e-34
Identities = 72/175 (41%), Positives = 101/175 (57%), Gaps = 1/175 (0%)
Query: 296 LVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMP 355
LV D+F+AGTETTS ++ + L++ EV K QEEID V+G+ R P + DR +MP
Sbjct: 7 LVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMP 66
Query: 356 YNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYS 415
Y +A+VHE R+ GVPH DT IP+ T +++ T++L D+ FP P
Sbjct: 67 YTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDREFPNPNI 126
Query: 416 FKPERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
F P FL NG D++ PF K C G+ LA+ +F+F TT+LQ F+L V
Sbjct: 127 FDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV 181
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 143 bits (347), Expect = 1e-33
Identities = 79/245 (32%), Positives = 130/245 (53%), Gaps = 6/245 (2%)
Query: 225 SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALRE 284
++FP+L P + +K ++RE++ H+ S + +DF+D ++ + +
Sbjct: 83 NNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKEHQASLDVNNP-RDFIDCFLIKMEQ 139
Query: 285 H--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGK 342
+ + ++ LV D+ AGTETTS ++ + L++ EV K QEEI+RVVG+
Sbjct: 140 EKDNQKSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 199
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
+R P + DR +MPY +A+VHE R+ +PH D IP+ T ++++ T+
Sbjct: 200 NRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTS 259
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGLAKHRCMGDALAKCNIFVFTTTML 461
+L D FP P F P FL G +YF PF K C+G+ LA+ +F+F T +L
Sbjct: 260 VLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL 319
Query: 462 QRFSL 466
Q F+L
Sbjct: 320 QNFNL 324
>BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein
protein.
Length = 310
Score = 142 bits (345), Expect = 2e-33
Identities = 69/184 (37%), Positives = 107/184 (58%), Gaps = 1/184 (0%)
Query: 284 EHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
+H + + ++ L+A DMF AGTETTS ++ + L++ EV K QEEI+ VVG++
Sbjct: 95 KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN 154
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
R P + DR +MPY +A+VHE R+ +PH D IP+ T ++++ T++
Sbjct: 155 RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSV 214
Query: 404 LLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
L ++ FP P F P FL +G D++ PF K CMG+ LA+ +F+F TT+LQ
Sbjct: 215 LHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQ 274
Query: 463 RFSL 466
F+L
Sbjct: 275 NFNL 278
>BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein.
Length = 431
Score = 142 bits (345), Expect = 2e-33
Identities = 69/184 (37%), Positives = 107/184 (58%), Gaps = 1/184 (0%)
Query: 284 EHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
+H + + ++ L+A DMF AGTETTS ++ + L++ EV K QEEI+ VVG++
Sbjct: 216 KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN 275
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
R P + DR +MPY +A+VHE R+ +PH D IP+ T ++++ T++
Sbjct: 276 RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSV 335
Query: 404 LLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
L ++ FP P F P FL +G D++ PF K CMG+ LA+ +F+F TT+LQ
Sbjct: 336 LHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQ 395
Query: 463 RFSL 466
F+L
Sbjct: 396 NFNL 399
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/134 (29%), Positives = 65/134 (48%), Gaps = 8/134 (5%)
Query: 25 KFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNS 84
+ P GP PI+G + +L K + K++ S Y PV + G IV+++
Sbjct: 28 RLPSGPTPLPIIG---NILQLDVKD--MSKSLTNFSKVY---GPVFTVYFGLKPIVVLHG 79
Query: 85 LEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
EA KE L + + +G F + G+L ++G+ WKE RRF + L+ FG G+
Sbjct: 80 YEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR 139
Query: 145 GMGETAKLEAEHIV 158
+ + + EA +V
Sbjct: 140 SIEDRVQEEARCLV 153
>M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrome
P-450 1 mRNA, complete cds, clone Hp1-2. ).
Length = 393
Score = 139 bits (336), Expect = 2e-32
Identities = 103/374 (27%), Positives = 179/374 (47%), Gaps = 22/374 (5%)
Query: 24 RKFPPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVN 83
RK PPGP PI+G ++ +++ + K+ S Y PV + G + IV+ +
Sbjct: 27 RKLPPGPTPLPIIGNMLQI-DVKD----ICKSFTNFSKVY---GPVFTVYFGMNPIVVFH 78
Query: 84 SLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGF 141
EA KE L + E+ GR Q T G G++ ++G+ WKE RRF + +L+ FG
Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTNLRNFGM 136
Query: 142 GRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDP 201
G+ + + + EA H +++ + ++ N + +++ R++ D
Sbjct: 137 GKRSIEDRVQEEA-HCLVEELRKTK---ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQ 192
Query: 202 QMKILQSMLFDLFAAVDMVGTAF-SHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELAR 260
L + F ++ ++FP+L P + +K ++RE++
Sbjct: 193 NFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVALTRSYIREKVKE 250
Query: 261 HKDSFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFC 318
H+ S + +DFMD ++ + + + + ++ LV D+F+AGTETTS ++ +
Sbjct: 251 HQASLDVNNP-RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 309
Query: 319 FSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHR 378
L++ EV K QEEID V+G+ R P + DR +MPY +A+VHE R+ GVPH
Sbjct: 310 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 369
Query: 379 ALRDTTLAGCHIPE 392
DT IP+
Sbjct: 370 VTTDTKFRNYLIPK 383
>AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 variant protein.
Length = 336
Score = 138 bits (334), Expect = 4e-32
Identities = 73/216 (33%), Positives = 112/216 (51%), Gaps = 6/216 (2%)
Query: 224 FSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR 283
+++FP P +R IK + +++ E + H S P+ +D D + +
Sbjct: 114 YNNFPSFLHYLP--GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP-RDLTDCLLVEME 170
Query: 284 E--HGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+ H Y+ + D+F AGTETTS ++ + L++ E++ K EEIDRV+G
Sbjct: 171 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 230
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
R+P++ DR MPY +A+VHE R +PH A RDT G IP+ T+VV
Sbjct: 231 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 290
Query: 402 NILLDENYFPEPYSFKPERFL-VNGRVSLPDHYFPF 436
++L D FP+P FKPE FL NG+ D++ PF
Sbjct: 291 SVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPF 326
>AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens
cDNA FLJ20359 fis, clone HEP16626. ).
Length = 408
Score = 134 bits (325), Expect = 5e-31
Identities = 98/372 (26%), Positives = 167/372 (44%), Gaps = 13/372 (3%)
Query: 68 PVLGLRIGKDRIVMVNSLEANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELW 125
PV + +G+ + V++ EA KE L +++ RP +Q G G+ + G W
Sbjct: 9 PVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGG--GIFFSSGARW 66
Query: 126 KEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILN 185
+ R+F ++ L G GR + + E + + + G RG N
Sbjct: 67 RAARQFTVRALHSLGVGREPVADKILQELKCLS---GQLDGYRGRPFPLA--LLGWAPSN 121
Query: 186 TLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIK 245
+ ++ G R++ DP L ++ ++ + G F + + L +R ++
Sbjct: 122 ITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL--FNVHPWLGALLQLHRPVLR 179
Query: 246 THKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCMDMFM 305
+ + LR L + P ++D I+ + ++E VA +DM M
Sbjct: 180 KIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVM 239
Query: 306 AGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECV 365
AGTETTS ++ + + R +VQ + QEE+DRV+G R P + D+ +PY A++HE V
Sbjct: 240 AGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHE-V 298
Query: 366 RHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VN 424
+ F+ VP DT L G +P+ T V+ T++LLDE + P F P FL N
Sbjct: 299 QRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDAN 358
Query: 425 GRVSLPDHYFPF 436
G + + PF
Sbjct: 359 GHFVKREAFLPF 370
>L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 217
Score = 132 bits (319), Expect = 3e-30
Identities = 66/172 (38%), Positives = 97/172 (56%), Gaps = 1/172 (0%)
Query: 296 LVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMP 355
LV D+ AGTETTS ++ + L++ EV K QEEI+RV+G++R P + DR +MP
Sbjct: 14 LVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMP 73
Query: 356 YNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYS 415
Y +A+VHE R+ +PH D IP+ T ++++ T++L D FP P
Sbjct: 74 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEM 133
Query: 416 FKPERFLVNGRVSLPDHYF-PFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
F P FL G +YF PF K C+G+ LA+ +F+F T +LQ F+L
Sbjct: 134 FDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 185
>AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1
protein.
Length = 251
Score = 132 bits (319), Expect = 3e-30
Identities = 68/187 (36%), Positives = 108/187 (57%), Gaps = 4/187 (2%)
Query: 280 RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRV 339
+ L E+ V S+ +++ + +D+F AG +T + ++S+ YLV VQRK QEE+D V
Sbjct: 31 KQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 89
Query: 340 VGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSN 399
+G+ R P ++DR ++PY EA + E RH F +PH RDT+L G +IP+ V N
Sbjct: 90 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 149
Query: 400 YTNILLDENYFPEPYSFKPERFLV-NGRVS--LPDHYFPFGLAKHRCMGDALAKCNIFVF 456
I D+ + P F PERFL +G + L + FG+ K +C+G+ +A+ +F+F
Sbjct: 150 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 209
Query: 457 TTTMLQR 463
+LQR
Sbjct: 210 LAILLQR 216
>M12079-1|AAA52152.1| 191|Homo sapiens POR protein.
Length = 191
Score = 131 bits (317), Expect = 5e-30
Identities = 65/175 (37%), Positives = 103/175 (58%), Gaps = 3/175 (1%)
Query: 292 SEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDR 351
S+ +++ + +D+F AG +T + ++S+ YLV VQRK QEE+D V+G+ R P ++DR
Sbjct: 9 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 68
Query: 352 PNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFP 411
++PY EA + E RH F +PH RDT+L G +IP+ V N I D+ +
Sbjct: 69 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 128
Query: 412 EPYSFKPERFLV-NGRVS--LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
P F PERFL +G + L + FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 129 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQR 183
>M12078-1|AAA52154.1| 192|Homo sapiens POR protein.
Length = 192
Score = 131 bits (317), Expect = 5e-30
Identities = 69/187 (36%), Positives = 106/187 (56%), Gaps = 7/187 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N + ++V + D+F AG +T + ++S+ YLV + E+QRK Q+E+D V+G++R P +
Sbjct: 6 NLIPQEKIVNLLNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 65
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDEN 408
+DRP +PY EA + E RH F +PH RDTTL G +IP+ V N + D
Sbjct: 66 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 125
Query: 409 YFPEPYSFKPERFLVNGRVSL-----PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
+ +P F+PERFL ++ G+ K RC+G+ LAK IF+F +LQ+
Sbjct: 126 LWEDPSEFRPERFLTADGTAINKPLSEKMMMLVGMGKRRCIGEVLAKWEIFLFLAILLQQ 185
Query: 464 --FSLVP 468
FS+ P
Sbjct: 186 LEFSVPP 192
>K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein.
Length = 331
Score = 130 bits (313), Expect = 1e-29
Identities = 83/287 (28%), Positives = 144/287 (50%), Gaps = 10/287 (3%)
Query: 185 NTLWTMMAGNRYNPSDPQM-KILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNF 243
N + +++ G+R++ D ++ + + ML + V+ G + F S++ +
Sbjct: 18 NVISSIVFGDRFDYKDRELLSLFRIMLVIVPVHVNSTGQLYEMFS--SVMKQLPGPQQQA 75
Query: 244 IKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVY-IRALREHGEVNT--YSEGQLVAMC 300
+ + + F+ +++ H P+ +DF+D + IR E NT Y E +LV
Sbjct: 76 FQLLQGLEDFIAKKV-EHNTPLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLE-KLVMTS 132
Query: 301 MDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAI 360
+++F+ GTET S ++ + F L++ V+ K EEIDRV+GK+R P DR MPY EA+
Sbjct: 133 LNLFIGGTETVSTTLRYGFLLLIKHPGVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAM 192
Query: 361 VHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPER 420
+HE R P R +DT +P+ T V ++L D + +P F P+
Sbjct: 193 IHEIQRFGDVIPMIWPGRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPIFLSKPQDFNPQH 252
Query: 421 FL-VNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
F + G D + PF + + C G+ LA+ +F+F TT++Q F L
Sbjct: 253 FTELEGAPKKSDAFVPFSIGQPNCFGEGLARMELFLFFTTVMQNFRL 299
>M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein.
Length = 495
Score = 126 bits (304), Expect = 2e-28
Identities = 114/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG L +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LSDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 125 bits (302), Expect = 3e-28
Identities = 109/430 (25%), Positives = 192/430 (44%), Gaps = 27/430 (6%)
Query: 65 KETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTD- 121
K P+ +R+G V+V + KE+L + D GRP+ + R+G+ D
Sbjct: 59 KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADS 117
Query: 122 GELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNV 181
G W+ RR + F + G + K+ + I + M+ I + V
Sbjct: 118 GAHWQLHRRLA---MATFALFKDGDQKLEKIICQEIST-LCDMLATHNGQSIDISFPVFV 173
Query: 182 YILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGY 240
+ N + + Y DP++ ++Q+ + + + P L I TL
Sbjct: 174 AVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK-DSLVDLVPWLKIFPNKTLEKL 232
Query: 241 RNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNT--------YS 292
++ +K + L + L +K+ F+ D + +D ++A N S
Sbjct: 233 KSHVKIRNDL---LNKILENYKEKFRSDSIT-NMLDTLMQAKMNSDNGNAGPDQDSELLS 288
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRP 352
+ ++ D+F AG ETT+ + + ++L+ +V++K EEID+ VG R P+++DR
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348
Query: 353 NMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPE 412
+ EA + E +R +PH+A D+++ + + T V+ N + +E + +
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408
Query: 413 PYSFKPERFLVNGRVSL--PD-HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPV 469
P F PERFL L P Y PFG C+G+ LA+ +F+ +LQRF L V
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL-EV 467
Query: 470 PGEG-LPSLD 478
P +G LPSL+
Sbjct: 468 PDDGQLPSLE 477
>M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPTMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKIQPFQVRLQPR 483
>AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFRERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 THLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P450,
subfamily XXIA (steroid 21-hydroxylase, congenital a
protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450
21-hydroxylase protein.
Length = 495
Score = 125 bits (301), Expect = 4e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 124 bits (300), Expect = 5e-28
Identities = 113/457 (24%), Positives = 207/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ ++FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGAPVCLGEPLARLDLFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 124 bits (300), Expect = 5e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKGDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 124 bits (300), Expect = 5e-28
Identities = 113/457 (24%), Positives = 206/457 (45%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVEEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 124 bits (299), Expect = 7e-28
Identities = 113/457 (24%), Positives = 205/457 (44%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens
cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
Length = 465
Score = 124 bits (299), Expect = 7e-28
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 211 QLGQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLQEGHVHMAAVDLLIGGTETTA 268
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 269 NTLSWAAVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 327
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 328 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 387
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 388 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 443
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 444 MQPFQVRLQPR 454
>AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 124 bits (298), Expect = 1e-27
Identities = 113/457 (24%), Positives = 205/457 (44%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F+ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSPLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 464
Score = 123 bits (297), Expect = 1e-27
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 210 QLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLLEGHVHMAAVDLLIGGTETTA 267
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 268 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 326
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 327 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 386
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 387 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 442
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 443 MQPFQVRLQPR 453
>AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 123 bits (297), Expect = 1e-27
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 211 QLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLLEGHVHMAAVDLLIGGTETTA 268
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 269 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 327
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 328 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 387
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 388 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 443
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 444 MQPFQVRLQPR 454
>AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 123 bits (297), Expect = 1e-27
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 211 QLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLLEGHVHMAAVDLLIGGTETTA 268
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 269 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 327
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 328 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 387
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 388 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 443
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 444 MQPFQVRLQPR 454
>AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 465
Score = 123 bits (297), Expect = 1e-27
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 211 QLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLLEGHVHMAAVDLLIGGTETTA 268
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 269 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 327
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 328 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 387
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 388 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 443
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 444 MQPFQVRLQPR 454
>AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450
21-hydroxylase protein.
Length = 403
Score = 123 bits (297), Expect = 1e-27
Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)
Query: 257 ELARHKDSFQPDKEDKDFMDVYIRALR----EHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+L +HK+S + +D MD ++ + E G EG + +D+ + GTETT+
Sbjct: 149 QLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGS-GQLLEGHVHMAAVDLLIGGTETTA 206
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSVNDRPNMPYNEAIVHECVRHF 368
++S+ +L+ E+Q++ QEE+D +G RVP DR +P A + E +R
Sbjct: 207 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLR 265
Query: 369 MGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVS 428
+PHR R ++++G IPE T+++ N LDE + P+ F P+RFL G+ S
Sbjct: 266 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 325
Query: 429 LPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATP--S 486
FG C+G+ LA+ +FV T +LQ F+L+P G+ LPSL + +
Sbjct: 326 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPSLQPLPHCSVILK 381
Query: 487 AAPFKALVIPR 497
PF+ + PR
Sbjct: 382 MQPFQVRLQPR 392
>M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein.
Length = 377
Score = 123 bits (296), Expect = 2e-27
Identities = 90/363 (24%), Positives = 171/363 (47%), Gaps = 22/363 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP+ P+LG ++ ++ G L +R K V + +G +VM+ +E
Sbjct: 31 PPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCGVE 82
Query: 87 ANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
A +E L + E GR K + G G+L +G WK RRF + +++FG G+
Sbjct: 83 AIREALVDNAEAFSGRGKIVIMDPVYQGY--GMLFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F+ N + +++ G R++ D +
Sbjct: 141 SVEERIQDEAQCLIEELRKSKG----ALVDPTFLFHSITANIICSIIFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARHKD 263
++ F + + + F + S G +R K + I ++ + +H++
Sbjct: 197 KTLNLFCQSFLLISSISSQL--FELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P +D +D Y+ + + + +S L+ + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-RDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + +EI++VVG R P+++DR MPY EA++ E R GVPH +
Sbjct: 314 MLKYPHVAERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHIVTQ 373
Query: 382 DTT 384
T+
Sbjct: 374 HTS 376
>BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein.
Length = 377
Score = 123 bits (296), Expect = 2e-27
Identities = 90/363 (24%), Positives = 171/363 (47%), Gaps = 22/363 (6%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP+ P+LG ++ ++ G L +R K V + +G +VM+ +E
Sbjct: 31 PPGPRPLPLLGNLLQM----DRRGLLKSFLRFRE----KYGDVFTVHLGPRPVVMLCGVE 82
Query: 87 ANKEMLFN--EDIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
A +E L + E GR K + G G+L +G WK RRF + +++FG G+
Sbjct: 83 AIREALVDNAEAFSGRGKIVIMDPVYQGY--GMLFANGNRWKVLRRFSVTTMRDFGMGKR 140
Query: 145 GMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNPSDPQMK 204
+ E + EA+ ++ ++ G A++ F+ N + +++ G R++ D +
Sbjct: 141 SVEERIQDEAQCLIEELRKSKG----ALVDPTFLFHSITANIICSIIFGKRFHYQDQEFL 196
Query: 205 ILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSG-YRNFIKTHKRIWKFLREELARHKD 263
++ F + + + F + S G +R K + I ++ + +H++
Sbjct: 197 KTLNLFCQSFLLISSISSQL--FELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254
Query: 264 SFQPDKEDKDFMDVYIRALREH--GEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSY 321
+ P +D +D Y+ + + + +S L+ + +F AGTETTS ++ + F
Sbjct: 255 TLDPSAP-RDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLL 313
Query: 322 LVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALR 381
+++ V + +EI++VVG R P+++DR MPY EA++ E R GVPH +
Sbjct: 314 MLKYPHVAERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHIVTQ 373
Query: 382 DTT 384
T+
Sbjct: 374 HTS 376
>AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 123 bits (296), Expect = 2e-27
Identities = 112/457 (24%), Positives = 205/457 (44%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTE T+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTENTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 122 bits (293), Expect = 4e-27
Identities = 112/457 (24%), Positives = 205/457 (44%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 49 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 107
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 108 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 161
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 162 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 213
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 214 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 272
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 273 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 331
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP DR +P A + E +R +PH R ++++G IPE T+++ N
Sbjct: 332 SRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGTVIIPNLQG 390
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 391 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 447
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+P G+ LPSL + + PF+ + PR
Sbjct: 448 AFTLLP-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 483
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 120 bits (288), Expect = 2e-26
Identities = 111/457 (24%), Positives = 204/457 (44%), Gaps = 40/457 (8%)
Query: 59 LSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNE--DIDGRPKGIFYQTRTWGERRG 116
L LT K P+ L +G +V++NS +E + + D GRP+ + Y+ +
Sbjct: 50 LGLTQ-KFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 108
Query: 117 VLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMH 176
L LWK ++ L G+ ++ + E + + + + + +
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIE 162
Query: 177 NFFNVYILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSI-VAP 235
F++ + + + G++ + ++ + + V +SH+ I + V P
Sbjct: 163 EEFSLLTCSIICYLTFGDKIKDDN--------LMPAYYKCIQEVLKTWSHWSIQIVDVIP 214
Query: 236 TLS-----GYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALR----EHG 286
L G R + ++ + +L +HK+S + +D MD ++ + E G
Sbjct: 215 FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEG 273
Query: 287 EVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----K 342
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G
Sbjct: 274 S-GQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
Query: 343 DRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTN 402
RVP D +P A + E +R +PHR R ++++G IPE T+++ N
Sbjct: 333 SRVP-YKDHARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 391
Query: 403 ILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
LDE + P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ
Sbjct: 392 AHLDETVWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
Query: 463 RFSLVPVPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
F+L+ G+ LPSL + + PF+ + PR
Sbjct: 449 AFTLLS-SGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
>M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein.
Length = 230
Score = 119 bits (286), Expect = 3e-26
Identities = 70/211 (33%), Positives = 112/211 (53%), Gaps = 11/211 (5%)
Query: 293 EGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG----KDRVPSV 348
EG + +D+ + GTETT+ ++S+ +L+ E+Q++ QEE+D +G RVP
Sbjct: 14 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGPGASSSRVP-Y 72
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDEN 408
DR +P A + E +R +PHR R ++++G IPE T+++ N LDE
Sbjct: 73 KDRARLPLLIATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 132
Query: 409 YFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVP 468
+ P+ F P+RFL G+ S FG C+G+ LA+ +FV T +LQ F+L+P
Sbjct: 133 VWERPHEFWPDRFLEPGKNS---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 189
Query: 469 VPGEGLPSLDHMDGATP--SAAPFKALVIPR 497
G+ LPSL + + PF+ + PR
Sbjct: 190 -SGDALPSLQPLPHCSVILKMQPFQVRLQPR 219
>AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family 1
subfamily A polypeptide 1 protein.
Length = 483
Score = 118 bits (285), Expect = 4e-26
Identities = 115/453 (25%), Positives = 204/453 (45%), Gaps = 60/453 (13%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLE 86
PPGP P++G + K +L A+ +S Y VL +RIG +V+++ L+
Sbjct: 40 PPGPWGWPLIGHMLTL----GKNPHL--ALSRMSQQY---GDVLQIRIGSTPVVVLSGLD 90
Query: 87 ANKEMLFNE--DIDGRPKGIFYQTRTWGERRGVLLTDGELWKEQRRFLIKHLKEFGFGRS 144
++ L + D GRP + + G+ G +W +RR LK F
Sbjct: 91 TIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASD 150
Query: 145 GMGETAKLEAEHIVIDVMHMIGD-----RGSAVIQMHNFFNVYILNTLWTMMAGNRYNPS 199
T+ EH+ + +I G + + V + N + + G RY+ +
Sbjct: 151 PASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN 210
Query: 200 DPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVA-PTLSGYRNFIKTHKRIWKFLREEL 258
++ L + L + F V G PIL + P+L+ +++ +++ + F+++ +
Sbjct: 211 HQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQKMV 266
Query: 259 ARHKDSFQPDKEDKDFMDVYI-----RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSK 313
H +F+ +D D I + L E+ V S+ +++ + +D+F AG +T +
Sbjct: 267 KEHYKTFEKG-HIRDITDSLIEHCQEKQLDENANVQL-SDEKIINIVLDLFGAGFDTVTT 324
Query: 314 SMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTF 373
++S+ YLV VQRK QEE+D V+G+ R P ++DR + PY EA + E TF
Sbjct: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHPPYMEAFILE--------TF 376
Query: 374 GVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV-NGRVS--LP 430
R ++ IP + V+ P F PERFL +G + L
Sbjct: 377 -------RHSSFVPFTIPHKKLWVN--------------PSEFLPERFLTPDGAIDKVLS 415
Query: 431 DHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
+ FG+ K +C+G+ +A+ +F+F +LQR
Sbjct: 416 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 448
>L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein.
Length = 169
Score = 108 bits (260), Expect = 4e-23
Identities = 54/137 (39%), Positives = 77/137 (56%), Gaps = 1/137 (0%)
Query: 331 KAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHI 390
K QEEI+RV+G++R P + DR +MPY +A+VHE R+ +PH D I
Sbjct: 1 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCDIKFRNYLI 60
Query: 391 PEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYF-PFGLAKHRCMGDALA 449
P+ T ++ + T++L D FP P F P FL G YF PF K C+G+ALA
Sbjct: 61 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 120
Query: 450 KCNIFVFTTTMLQRFSL 466
+F+F T++LQ F+L
Sbjct: 121 GMELFLFLTSILQNFNL 137
>AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1
protein.
Length = 175
Score = 108 bits (259), Expect = 5e-23
Identities = 55/143 (38%), Positives = 83/143 (58%), Gaps = 1/143 (0%)
Query: 280 RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRV 339
+ L E+ V S+ +++ + +D+F AG +T + ++S+ YLV VQRK QEE+D V
Sbjct: 31 KQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 89
Query: 340 VGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSN 399
+G+ R P ++DR ++PY EA + E RH F +PH RDT+L G +IP+ V N
Sbjct: 90 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 149
Query: 400 YTNILLDENYFPEPYSFKPERFL 422
I D+ + P F PERFL
Sbjct: 150 QWQINHDQKLWVNPSEFLPERFL 172
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 103 bits (248), Expect = 1e-21
Identities = 96/373 (25%), Positives = 166/373 (44%), Gaps = 23/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAV- 172
+ + + + E WK R L F G+ + E + A++ + V ++ +R +
Sbjct: 115 KSAISIAEDEEWKRLRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRRERETGKP 169
Query: 173 IQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFP 228
+ + + F Y ++ + + G + NP DP ++ + +L F +D + + FP
Sbjct: 170 VTLKDVFGAYSMDVITSSSFGVNVDSLNNPQDPLVENTKKLL--RFDFLDPFFLSITVFP 227
Query: 229 ILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPD--KEDKDFMDVYIRALREHG 286
L + L N + + FLR+ + R K+S D K DF+ + I + +
Sbjct: 228 FLIPILEVL----NICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSK 283
Query: 287 EVNTY---SEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E ++ S+ +LVA + AG ETTS +SF L +VQ+K QEEID V+
Sbjct: 284 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK 343
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + M Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 344 APPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGWVVMIPSYAL 402
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 403 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 462
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 463 NFSFKPCKETQIP 475
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 103 bits (248), Expect = 1e-21
Identities = 96/373 (25%), Positives = 166/373 (44%), Gaps = 23/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAV- 172
+ + + + E WK R L F G+ + E + A++ + V ++ +R +
Sbjct: 115 KSAISIAEDEEWKRLRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRRERETGKP 169
Query: 173 IQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHFP 228
+ + + F Y ++ + + G + NP DP ++ + +L F +D + + FP
Sbjct: 170 VTLKDVFGAYSMDVITSSSFGVNVDSLNNPQDPLVENTKKLL--RFDFLDPFFLSITVFP 227
Query: 229 ILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPD--KEDKDFMDVYIRALREHG 286
L + L N + + FLR+ + R K+S D K DF+ + I + +
Sbjct: 228 FLIPILEVL----NICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSK 283
Query: 287 EVNTY---SEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E ++ S+ +LVA + AG ETTS +SF L +VQ+K QEEID V+
Sbjct: 284 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK 343
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + M Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 344 APPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGWVVMIPSYAL 402
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 403 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 462
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 463 NFSFKPCKETQIP 475
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 101 bits (243), Expect = 4e-21
Identities = 85/315 (26%), Positives = 142/315 (45%), Gaps = 16/315 (5%)
Query: 170 SAVIQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
++++ ++ F Y ++ + + G + NP DP ++ + +L F +D + +
Sbjct: 17 TSLVLLYIVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL--RFDFLDPFFLSIT 74
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPD--KEDKDFMDVYIRAL- 282
FP L + L N + + FLR+ + R K+S D K DF+ + I +
Sbjct: 75 VFPFLIPILEVL----NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 130
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + AG ETTS +SF L +VQ+K QEEID V+
Sbjct: 131 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 190
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
P+ + M Y + +V+E +R F + +D + G IP+ +V+
Sbjct: 191 NKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 249
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +
Sbjct: 250 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 309
Query: 461 LQRFSLVPVPGEGLP 475
LQ FS P +P
Sbjct: 310 LQNFSFKPCKETQIP 324
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 101 bits (243), Expect = 4e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGCETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLA 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 125 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 178
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 179 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 238
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 239 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 297
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 298 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 357
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 358 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 401
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 101 bits (242), Expect = 6e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 101 bits (241), Expect = 8e-21
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 TYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 12/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSITVFPFLIPILEVL----NICVFPREVTNFLRK 251
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 371 MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 97/336 (28%), Positives = 147/336 (43%), Gaps = 21/336 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPERFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTM 460
+ D Y+ EP F PERF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRA 459
Query: 461 LQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 LQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 491
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 100 bits (239), Expect = 1e-20
Identities = 83/283 (29%), Positives = 125/283 (44%), Gaps = 11/283 (3%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + L F +D + + FP L+ V L N K FL +
Sbjct: 198 NPQDPFVESTKKFL--KFGFLDPLFLSIILFPFLTPVFEAL----NVSLFPKDTINFLSK 251
Query: 257 ELARHKDSFQPDKEDK--DFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K S DK+ DF+ + I + +E S+ +L A + AG ETTS
Sbjct: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K Q+EID V+ P+ + M Y + +V+E +R F
Sbjct: 312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVA 370
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDH 432
+ ++D + G IP+ +MVV + D Y+ EP F+PERF P
Sbjct: 371 IRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430
Query: 433 YFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 99.1 bits (236), Expect = 3e-20
Identities = 99/372 (26%), Positives = 159/372 (42%), Gaps = 23/372 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + L + E WK R L F G+ + E + A++ +++ + ++G
Sbjct: 115 KSAISLAEDEEWKRIRSLLSP---TFTSGK--LKEMFPIIAQYGDVLVRNLRREAEKGKP 169
Query: 172 VIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V + + F Y I T + + + NP DP ++ + L F +D + + F
Sbjct: 170 VT-LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL--KFGFLDPLFLSIILF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL--R 283
P L+ V L N K FL + + R K S DK+ DF+ + I + +
Sbjct: 227 PFLTPVFEAL----NVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 282
Query: 284 EHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E S+ +L A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + M Y + +V+E +R F + +D + G IP+ +MVV +
Sbjct: 343 APPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
D Y+ EP F+PERF P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461
Query: 464 FSLVPVPGEGLP 475
FS P +P
Sbjct: 462 FSFKPCKETQIP 473
>DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1
protein.
Length = 195
Score = 99.1 bits (236), Expect = 3e-20
Identities = 56/174 (32%), Positives = 92/174 (52%), Gaps = 4/174 (2%)
Query: 327 EVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLA 386
+VQ + Q E+D+VVG+DR+P + D+PN+PY A ++E +R + H +T++
Sbjct: 3 DVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTISHATTANTSVL 62
Query: 387 GCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFL-VNGRVS--LPDHYFPFGLAKHRC 443
G HIP+DT+V N ++ D +P P +F P RFL +G ++ L F + K RC
Sbjct: 63 GYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRC 122
Query: 444 MGDALAKCNIFVFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPR 497
+G+ L+K +F+F + + + P E ++ G T FK V R
Sbjct: 123 IGEELSKMQLFLFISILAHQCDFRANPNEP-AKMNFSYGLTIKPKSFKVNVTLR 175
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 99.1 bits (236), Expect = 3e-20
Identities = 99/372 (26%), Positives = 159/372 (42%), Gaps = 23/372 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + L + E WK R L F G+ + E + A++ +++ + ++G
Sbjct: 115 KSAISLAEDEEWKRIRSLLSP---TFTSGK--LKEMFPIIAQYGDVLVRNLRREAEKGKP 169
Query: 172 VIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V + + F Y I T + + + NP DP ++ + L F +D + + F
Sbjct: 170 VT-LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL--KFGFLDPLFLSIILF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL--R 283
P L+ V L N K FL + + R K S DK+ DF+ + I + +
Sbjct: 227 PFLTPVFEAL----NVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 282
Query: 284 EHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E S+ +L A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + M Y + +V+E +R F + +D + G IP+ +MVV +
Sbjct: 343 APPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
D Y+ EP F+PERF P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461
Query: 464 FSLVPVPGEGLP 475
FS P +P
Sbjct: 462 FSFKPCKETQIP 473
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 99.1 bits (236), Expect = 3e-20
Identities = 99/372 (26%), Positives = 159/372 (42%), Gaps = 23/372 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + L + E WK R L F G+ + E + A++ +++ + ++G
Sbjct: 115 KSAISLAEDEEWKRIRSLLSP---TFTSGK--LKEMFPIIAQYGDVLVRNLRREAEKGKP 169
Query: 172 VIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V + + F Y I T + + + NP DP ++ + L F +D + + F
Sbjct: 170 VT-LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL--KFGFLDPLFLSIILF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL--R 283
P L+ V L N K FL + + R K S DK+ DF+ + I + +
Sbjct: 227 PFLTPVFEAL----NVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 282
Query: 284 EHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E S+ +L A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + M Y + +V+E +R F + +D + G IP+ +MVV +
Sbjct: 343 APPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQR 463
D Y+ EP F+PERF P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461
Query: 464 FSLVPVPGEGLP 475
FS P +P
Sbjct: 462 FSFKPCKETQIP 473
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 96.7 bits (230), Expect = 2e-19
Identities = 82/284 (28%), Positives = 127/284 (44%), Gaps = 13/284 (4%)
Query: 197 NPSDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLRE 256
NP DP ++ + +L F +D + FP L + L N + + FLR+
Sbjct: 198 NPQDPFVENTKKLL--RFDFLDPFFLSII-FPFLIPILEVL----NICVFPREVTNFLRK 250
Query: 257 ELARHKDSFQPD--KEDKDFMDVYIRAL--REHGEVNTYSEGQLVAMCMDMFMAGTETTS 312
+ R K+S D K DF+ + I + +E S+ +LVA + AG ETTS
Sbjct: 251 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 310
Query: 313 KSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRT 372
+SF L +VQ+K QEEID V+ P+ + M Y + +V+E +R F
Sbjct: 311 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIA 369
Query: 373 FGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSL-PD 431
+ +D + G IP+ +V+ + D Y+ EP F PERF + ++ P
Sbjct: 370 MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 429
Query: 432 HYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP 475
Y PFG C+G A N+ + +LQ FS P +P
Sbjct: 430 TYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473
>AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1
protein.
Length = 144
Score = 96.7 bits (230), Expect = 2e-19
Identities = 49/134 (36%), Positives = 77/134 (57%), Gaps = 1/134 (0%)
Query: 280 RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRV 339
+ L E+ V S+ +++ + +D+F AG +T + ++S+ YLV VQRK QEE+D V
Sbjct: 11 KQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 69
Query: 340 VGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSN 399
+G+ R P ++DR ++PY EA + E RH F +PH RDT+L G +IP+ V N
Sbjct: 70 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 129
Query: 400 YTNILLDENYFPEP 413
I D+ + P
Sbjct: 130 QWQINHDQKLWVNP 143
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 96.3 bits (229), Expect = 2e-19
Identities = 97/337 (28%), Positives = 147/337 (43%), Gaps = 22/337 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPE-RFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTT 459
+ D Y+ EP F PE RF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIR 459
Query: 460 MLQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 ALQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 492
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 96.3 bits (229), Expect = 2e-19
Identities = 97/337 (28%), Positives = 147/337 (43%), Gaps = 22/337 (6%)
Query: 170 SAVIQMHNFFNVY----ILNTLWTMMAGNRYNPSDPQMKILQSMLFDLFAAVDMVGTAFS 225
S I + +FF Y I TL+ + + NP DP +K ++ +L F +D S
Sbjct: 167 SKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLLLIS 224
Query: 226 HFPILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL- 282
FP L+ V L N K + FL+ + R K+S DK+ DF I +
Sbjct: 225 LFPFLTPVFEAL----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280
Query: 283 -REHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVG 341
+E S+ +LVA + + A +TTS ++ F L +VQ+K QEEID V+
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340
Query: 342 KDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYT 401
+ + M Y + +V+E +R F V +D + G IP+ V+
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIY 399
Query: 402 NILLDENYFPEPYSFKPE-RFLVNGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTT 459
+ D Y+ EP F PE RF + S+ + Y PFG C+G A NI +
Sbjct: 400 ALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIR 459
Query: 460 MLQRFSLVPVPGEGLP-SLDHMDGATPSAAPFKALVI 495
LQ FS P +P LD++ P P K +V+
Sbjct: 460 ALQNFSFKPCKETQIPLKLDNL----PILQPEKPIVL 492
>AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1
protein.
Length = 157
Score = 94.7 bits (225), Expect = 7e-19
Identities = 48/128 (37%), Positives = 75/128 (58%), Gaps = 1/128 (0%)
Query: 280 RALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRV 339
+ L E+ V S+ +++ + +D+F AG +T + ++S+ YLV VQRK QEE+D V
Sbjct: 31 KQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 89
Query: 340 VGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSN 399
+G+ R P ++DR ++PY EA + E RH F +PH RDT+L G +IP+ V N
Sbjct: 90 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 149
Query: 400 YTNILLDE 407
I D+
Sbjct: 150 QWQINHDQ 157
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 92.3 bits (219), Expect = 4e-18
Identities = 90/373 (24%), Positives = 162/373 (43%), Gaps = 24/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + + + E WK R L F G+ + E + A++ +++ + + G
Sbjct: 115 KNAISIAEDEEWKRIRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRREAETGKP 169
Query: 172 VIQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V H F Y ++ + + G + NP DP ++ + +L F +D + F
Sbjct: 170 VTLKH-VFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL--RFNPLDPFVLSIKVF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSF--QPDKEDKDFMDVYIRALR-E 284
P L+ + L N +++ FL + + + K+ + K DF+ + I + +
Sbjct: 227 PFLTPILEAL----NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSK 282
Query: 285 HGEVN-TYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E + S+ +L+A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + + Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 343 APPTYDTVLQLEYLDMVVNETLRLF-PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 462 NFSFKPCKETQIP 474
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 92.3 bits (219), Expect = 4e-18
Identities = 90/373 (24%), Positives = 162/373 (43%), Gaps = 24/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + + + E WK R L F G+ + E + A++ +++ + + G
Sbjct: 115 KNAISIAEDEEWKRIRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRREAETGKP 169
Query: 172 VIQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V H F Y ++ + + G + NP DP ++ + +L F +D + F
Sbjct: 170 VTLKH-VFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL--RFNPLDPFVLSIKVF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSF--QPDKEDKDFMDVYIRALR-E 284
P L+ + L N +++ FL + + + K+ + K DF+ + I + +
Sbjct: 227 PFLTPILEAL----NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSK 282
Query: 285 HGEVN-TYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E + S+ +L+A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + + Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 343 APPTYDTVLQLEYLDMVVNETLRLF-PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 462 NFSFKPCKETQIP 474
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 92.3 bits (219), Expect = 4e-18
Identities = 90/373 (24%), Positives = 162/373 (43%), Gaps = 24/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + + + E WK R L F G+ + E + A++ +++ + + G
Sbjct: 115 KNAISIAEDEEWKRIRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRREAETGKP 169
Query: 172 VIQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V H F Y ++ + + G + NP DP ++ + +L F +D + F
Sbjct: 170 VTLKH-VFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL--RFNPLDPFVLSIKVF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSF--QPDKEDKDFMDVYIRALR-E 284
P L+ + L N +++ FL + + + K+ + K DF+ + I + +
Sbjct: 227 PFLTPILEAL----NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSK 282
Query: 285 HGEVN-TYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E + S+ +L+A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + + Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 343 APPTYDTVLQLEYLDMVVNETLRLF-PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 462 NFSFKPCKETQIP 474
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 92.3 bits (219), Expect = 4e-18
Identities = 90/373 (24%), Positives = 162/373 (43%), Gaps = 24/373 (6%)
Query: 114 RRGVLLTDGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEH--IVIDVMHMIGDRGSA 171
+ + + + E WK R L F G+ + E + A++ +++ + + G
Sbjct: 115 KNAISIAEDEEWKRIRSLLSP---TFTSGK--LKEMVPIIAQYGDVLVRNLRREAETGKP 169
Query: 172 VIQMHNFFNVYILNTLWTMMAG----NRYNPSDPQMKILQSMLFDLFAAVDMVGTAFSHF 227
V H F Y ++ + + G + NP DP ++ + +L F +D + F
Sbjct: 170 VTLKH-VFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL--RFNPLDPFVLSIKVF 226
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSF--QPDKEDKDFMDVYIRALR-E 284
P L+ + L N +++ FL + + + K+ + K DF+ + I + +
Sbjct: 227 PFLTPILEAL----NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSK 282
Query: 285 HGEVN-TYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKD 343
E + S+ +L+A + AG ETTS +SF L +VQ+K Q+EID V+
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342
Query: 344 RVPSVNDRPNMPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNI 403
P+ + + Y + +V+E +R F + +D + G IP+ +V+ +
Sbjct: 343 APPTYDTVLQLEYLDMVVNETLRLF-PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 404 LLDENYFPEPYSFKPERFLVNGRVSL-PDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQ 462
D Y+ EP F PERF + ++ P Y PFG C+G A N+ + +LQ
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 463 RFSLVPVPGEGLP 475
FS P +P
Sbjct: 462 NFSFKPCKETQIP 474
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 88.6 bits (210), Expect = 4e-17
Identities = 74/254 (29%), Positives = 113/254 (44%), Gaps = 11/254 (4%)
Query: 248 KRIWKFLREELARHKDSFQPDKEDK--DFMDVYIRAL--REHGEVNTYSEGQLVAMCMDM 303
K + FL+ + R K+S DK+ DF I + +E S+ +LVA + +
Sbjct: 133 KDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 192
Query: 304 FMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHE 363
A +TTS ++ F L +VQ+K QEEID V+ + + M Y + +V+E
Sbjct: 193 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 252
Query: 364 CVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEPYSFKPERFLV 423
+R F V +D + G IP+ V+ + D Y+ EP F PERF
Sbjct: 253 TLRLF-PVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 311
Query: 424 NGRVSLPDH-YFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGEGLP-SLDHMD 481
+ S+ + Y PFG C+G A NI + LQ FS P +P LD++
Sbjct: 312 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 370
Query: 482 GATPSAAPFKALVI 495
P P K +V+
Sbjct: 371 ---PILQPEKPIVL 381
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 87.0 bits (206), Expect = 1e-16
Identities = 108/459 (23%), Positives = 199/459 (43%), Gaps = 41/459 (8%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKET-PVLGLRIGKDRIVMVNSL 85
PP P + +LG +K E G + ++++ L + K+ PV+ + + V+V S
Sbjct: 36 PPRPSF--LLGHLPCFWKKDEVGG---RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSP 90
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGER---RGVLLT-DGELWKEQRRFLIKHLKEFGF 141
E+ K+ L + + K +GER +G++ + E W +QRR + + F
Sbjct: 91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-----DLAF 145
Query: 142 GRSGMG---ETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNP 198
RS + ET +AE +V +++ D G + M + ++ L G
Sbjct: 146 SRSSLVSLMETFNEKAEQLV-EILEAKAD-GQTPVSMQDMLTYTAMDILAKAAFGM---- 199
Query: 199 SDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREE- 257
+ +L L AV ++ + + +A L G R ++ + +FLR+
Sbjct: 200 ---ETSMLLGAQKPLSQAVKLMLEGIT--ASRNTLAKFLPGKRKQLREVRESIRFLRQVG 254
Query: 258 ---LARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKS 314
+ R +++ + +E D+ + L+ E + L+ + F+AG ET++
Sbjct: 255 RDWVQRRREALKRGEEVP--ADILTQILK--AEEGAQDDEGLLDNFVTFFIAGHETSANH 310
Query: 315 MSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFG 374
++F L R+ E+ + Q E+D V+G R D + Y ++ E +R + +G
Sbjct: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY-PPAWG 369
Query: 375 VPHRALRDTTLAGCHIPEDT-MVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHY 433
+T + G +P +T ++ S Y +D YF +P +F P+RF G Y
Sbjct: 370 TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD-TYFEDPLTFNPDRF-GPGAPKPRFTY 427
Query: 434 FPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGE 472
FPF L C+G A+ + V +LQR VPG+
Sbjct: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 87.0 bits (206), Expect = 1e-16
Identities = 108/459 (23%), Positives = 199/459 (43%), Gaps = 41/459 (8%)
Query: 27 PPGPKWTPILGCAKEVYKLREKTGYLYKAVRELSLTYCKET-PVLGLRIGKDRIVMVNSL 85
PP P + +LG +K E G + ++++ L + K+ PV+ + + V+V S
Sbjct: 36 PPRPSF--LLGHLPCFWKKDEVGG---RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSP 90
Query: 86 EANKEMLFNEDIDGRPKGIFYQTRTWGER---RGVLLT-DGELWKEQRRFLIKHLKEFGF 141
E+ K+ L + + K +GER +G++ + E W +QRR + + F
Sbjct: 91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-----DLAF 145
Query: 142 GRSGMG---ETAKLEAEHIVIDVMHMIGDRGSAVIQMHNFFNVYILNTLWTMMAGNRYNP 198
RS + ET +AE +V +++ D G + M + ++ L G
Sbjct: 146 SRSSLVSLMETFNEKAEQLV-EILEAKAD-GQTPVSMQDMLTYTAMDILAKAAFGM---- 199
Query: 199 SDPQMKILQSMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYRNFIKTHKRIWKFLREE- 257
+ +L L AV ++ + + +A L G R ++ + +FLR+
Sbjct: 200 ---ETSMLLGAQKPLSQAVKLMLEGIT--ASRNTLAKFLPGKRKQLREVRESIRFLRQVG 254
Query: 258 ---LARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQLVAMCMDMFMAGTETTSKS 314
+ R +++ + +E D+ + L+ E + L+ + F+AG ET++
Sbjct: 255 RDWVQRRREALKRGEEVP--ADILTQILK--AEEGAQDDEGLLDNFVTFFIAGHETSANH 310
Query: 315 MSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNMPYNEAIVHECVRHFMGRTFG 374
++F L R+ E+ + Q E+D V+G R D + Y ++ E +R + +G
Sbjct: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY-PPAWG 369
Query: 375 VPHRALRDTTLAGCHIPEDT-MVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHY 433
+T + G +P +T ++ S Y +D YF +P +F P+RF G Y
Sbjct: 370 TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD-TYFEDPLTFNPDRF-GPGAPKPRFTY 427
Query: 434 FPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSLVPVPGE 472
FPF L C+G A+ + V +LQR VPG+
Sbjct: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N S+ +L A ++ +A ETT+ S+ + L R +VQ+K +EI V+ +++VP
Sbjct: 52 NRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA 111
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPH--RALRDTTLAGCH-IPEDTMVVSNYTNILL 405
D NMPY +A C++ M T VP R L T+ G + +P+ T+++ N +
Sbjct: 112 EDLRNMPYLKA----CLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 167
Query: 406 DENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFS 465
E+ F + F+PER+L P + PFG+ K C+G LA+ + + +++++
Sbjct: 168 SEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 227
Query: 466 LVPVPGEGLPSLDHMDGATPS 486
+ E + L H PS
Sbjct: 228 IQATDNEPVEML-HSGTLVPS 247
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N S+ +L A ++ +A ETT+ S+ + L R +VQ+K +EI V+ +++VP
Sbjct: 167 NRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA 226
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPH--RALRDTTLAGCH-IPEDTMVVSNYTNILL 405
D NMPY +A C++ M T VP R L T+ G + +P+ T+++ N +
Sbjct: 227 EDLRNMPYLKA----CLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 282
Query: 406 DENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFS 465
E+ F + F+PER+L P + PFG+ K C+G LA+ + + +++++
Sbjct: 283 SEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 342
Query: 466 LVPVPGEGLPSLDHMDGATPS 486
+ E + L H PS
Sbjct: 343 IQATDNEPVEML-HSGTLVPS 362
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N S+ +L A ++ +A ETT+ S+ + L R +VQ+K +EI V+ +++VP
Sbjct: 309 NRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA 368
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPH--RALRDTTLAGCH-IPEDTMVVSNYTNILL 405
D NMPY +A C++ M T VP R L T+ G + +P+ T+++ N +
Sbjct: 369 EDLRNMPYLKA----CLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 424
Query: 406 DENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFS 465
E+ F + F+PER+L P + PFG+ K C+G LA+ + + +++++
Sbjct: 425 SEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 484
Query: 466 LVPVPGEGLPSLDHMDGATPS 486
+ E + L H PS
Sbjct: 485 IQATDNEPVEML-HSGTLVPS 504
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N S+ +L A ++ +A ETT+ S+ + L R +VQ+K +EI V+ +++VP
Sbjct: 167 NRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA 226
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPH--RALRDTTLAGCH-IPEDTMVVSNYTNILL 405
D NMPY +A C++ M T VP R L T+ G + +P+ T+++ N +
Sbjct: 227 EDLRNMPYLKA----CLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 282
Query: 406 DENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFS 465
E+ F + F+PER+L P + PFG+ K C+G LA+ + + +++++
Sbjct: 283 SEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 342
Query: 466 LVPVPGEGLPSLDHMDGATPS 486
+ E + L H PS
Sbjct: 343 IQATDNEPVEML-HSGTLVPS 362
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 85.4 bits (202), Expect = 4e-16
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 289 NTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSV 348
N S+ +L A ++ +A ETT+ S+ + L R +VQ+K +EI V+ +++ P
Sbjct: 308 NRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE 367
Query: 349 NDRPNMPYNEAIVHECVRHFMGRTFGVPH--RALRDTTLAGCH-IPEDTMVVSNYTNILL 405
D NMPY +A C++ M T GVP R L T+ G + +P+ T+++ N +
Sbjct: 368 EDLRNMPYLKA----CLKESMRLTPGVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGS 423
Query: 406 DENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIFVFTTTMLQRFS 465
E+ F + F+PER+L P + PFG+ K C+G LA+ + + +++++
Sbjct: 424 SEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 483
Query: 466 LVPVPGEGLPSLDHMDGATPS 486
+ E + L H PS
Sbjct: 484 IQATDNEPVEML-HSGTLVPS 503
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 85.0 bits (201), Expect = 5e-16
Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 5/175 (2%)
Query: 295 QLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNM 354
++ A +M +AG +TTS ++S+ L R EVQ+ EI + +G+ VP+ D P +
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVPTAADVPKV 228
Query: 355 PYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDT-MVVSNYTNILLDENYFPEP 413
P A++ E +R F G D + G IP+ T + + +Y DEN FP
Sbjct: 229 PLVRALLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRA 286
Query: 414 YSFKPERFLVNGRVSLPDHY--FPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
F+PER+L G + D++ PFG C+G +A+ I + +LQ F +
Sbjct: 287 KEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEI 341
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 85.0 bits (201), Expect = 5e-16
Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 5/175 (2%)
Query: 295 QLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPNM 354
++ A +M +AG +TTS ++S+ L R EVQ+ EI + +G+ VP+ D P +
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKV 228
Query: 355 PYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDT-MVVSNYTNILLDENYFPEP 413
P A++ E +R F G D + G IP+ T + + +Y DEN FP
Sbjct: 229 PLVRALLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRA 286
Query: 414 YSFKPERFLVNGRVSLPDHY--FPFGLAKHRCMGDALAKCNIFVFTTTMLQRFSL 466
F+PER+L G + D++ PFG C+G +A+ I + +LQ F +
Sbjct: 287 KEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEI 341
>AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P450
2E1 protein.
Length = 97
Score = 83.4 bits (197), Expect = 2e-15
Identities = 41/97 (42%), Positives = 53/97 (54%), Gaps = 1/97 (1%)
Query: 354 MPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPEDTMVVSNYTNILLDENYFPEP 413
MPY +A+VHE R +PH A RDT G IP+ T+VV ++L D FP+P
Sbjct: 1 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 60
Query: 414 YSFKPERFL-VNGRVSLPDHYFPFGLAKHRCMGDALA 449
FKPE FL NG+ D++ PF K C G+ LA
Sbjct: 61 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLA 97
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 83.0 bits (196), Expect = 2e-15
Identities = 63/252 (25%), Positives = 116/252 (46%), Gaps = 14/252 (5%)
Query: 228 PILSIVAPTLSGYRNFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGE 287
P+L L G+ K K + E+L + Q D + Y+ L G+
Sbjct: 263 PVLPFWKRYLDGWNAIFSFGK---KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ 319
Query: 288 VNTYSEGQLVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPS 347
+ S + + ++ MAG +TTS ++++ +L ++ E+Q+ EE+ VV +VP
Sbjct: 320 L---SPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPAGQVPQ 376
Query: 348 VNDRPNMPYNEAIVHECVRHFMGRTFGVPHRAL-RDTTLAGCHIPEDTMVVSNYTNILLD 406
D +MP +A++ E +R + R + ++ + G P++T V + + D
Sbjct: 377 HKDFAHMPLLKAVLKETLRLY--PVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYEVSRD 434
Query: 407 ENYFPEPYSFKPERFLVNGRVSLP--DHYF---PFGLAKHRCMGDALAKCNIFVFTTTML 461
F EP SF+P R+L N + + P H F PFG C+G +A+ + + ++
Sbjct: 435 PTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLI 494
Query: 462 QRFSLVPVPGEG 473
Q++ +V P G
Sbjct: 495 QKYKVVLAPETG 506
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.324 0.139 0.431
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 74,346,888
Number of Sequences: 224733
Number of extensions: 3211682
Number of successful extensions: 6723
Number of sequences better than 10.0: 464
Number of HSP's better than 10.0 without gapping: 327
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 5559
Number of HSP's gapped (non-prelim): 573
length of query: 498
length of database: 73,234,838
effective HSP length: 93
effective length of query: 405
effective length of database: 52,334,669
effective search space: 21195540945
effective search space used: 21195540945
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (22.0 bits)
S2: 67 (31.1 bits)
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