Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002069-TA|BGIBMGA002069-PA|IPR001452|Src homology-3,
IPR000980|SH2 motif, IPR001245|Tyrosine protein kinase,
IPR011009|Protein kinase-like, IPR000719|Protein kinase,
IPR008266|Tyrosine protein kinase, active site, IPR001720|PI3 kinase,
P85 regulatory subunit
(473 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 779 0.0
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 778 0.0
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 754 0.0
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 686 0.0
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 672 0.0
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 658 0.0
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 588 e-166
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 565 e-160
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 386 e-106
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 347 3e-94
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 342 1e-92
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 341 3e-92
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 336 5e-91
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 332 1e-89
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 331 2e-89
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 331 3e-89
UniRef50_A2RQD6 Cluster: Bcr-abl1 e6a2 chimeric protein; n=10; E... 330 4e-89
UniRef50_A2RQD7 Cluster: Bcr-abl1 e19a2 chimeric protein; n=2; H... 329 1e-88
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 327 3e-88
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 325 2e-87
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 323 5e-87
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 319 9e-86
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 318 2e-85
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 315 2e-84
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 301 2e-80
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 296 7e-79
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 287 6e-76
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 285 2e-75
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 284 3e-75
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 283 9e-75
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 281 3e-74
UniRef50_A2RQD3 Cluster: Bcr-abl1 e13a3 chimeric protein; n=21; ... 280 5e-74
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 278 3e-73
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 277 3e-73
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 276 8e-73
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 276 1e-72
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 270 5e-71
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 268 3e-70
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 267 5e-70
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 260 7e-68
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 257 5e-67
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 256 7e-67
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 256 1e-66
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 249 1e-64
UniRef50_Q4RNL0 Cluster: Chromosome 21 SCAF15012, whole genome s... 243 7e-63
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 240 5e-62
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 238 3e-61
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 237 3e-61
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 229 9e-59
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 225 3e-57
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 222 2e-56
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 219 1e-55
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 217 4e-55
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 215 2e-54
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 210 5e-53
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 210 8e-53
UniRef50_Q4RNX3 Cluster: Chromosome 10 SCAF15009, whole genome s... 208 2e-52
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 204 5e-51
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 200 5e-50
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 200 8e-50
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 200 8e-50
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 198 3e-49
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 196 1e-48
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 196 1e-48
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 188 2e-46
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 188 3e-46
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 187 6e-46
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 187 6e-46
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 186 1e-45
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 186 1e-45
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 186 1e-45
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 185 2e-45
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 185 3e-45
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 184 3e-45
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 184 4e-45
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 184 6e-45
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 184 6e-45
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 184 6e-45
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 183 8e-45
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 183 8e-45
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 183 1e-44
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 183 1e-44
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 182 1e-44
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 182 1e-44
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 182 2e-44
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 182 2e-44
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 182 2e-44
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 182 2e-44
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 182 2e-44
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 182 2e-44
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 182 2e-44
UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31... 182 2e-44
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 180 6e-44
UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:... 180 6e-44
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 180 7e-44
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 180 7e-44
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 180 1e-43
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 180 1e-43
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 180 1e-43
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 180 1e-43
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 179 1e-43
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 179 1e-43
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 179 1e-43
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 179 1e-43
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 179 1e-43
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 179 1e-43
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 179 2e-43
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 179 2e-43
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 179 2e-43
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 178 2e-43
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 178 2e-43
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 178 3e-43
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 178 3e-43
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 177 4e-43
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 177 5e-43
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 177 5e-43
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 177 5e-43
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 177 7e-43
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 177 7e-43
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 177 7e-43
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 176 9e-43
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 176 1e-42
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 176 1e-42
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 176 1e-42
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 175 2e-42
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 175 2e-42
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 175 2e-42
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 175 2e-42
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 175 2e-42
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 175 3e-42
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 174 4e-42
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 174 4e-42
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 174 4e-42
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 174 4e-42
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 174 5e-42
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 174 5e-42
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 173 6e-42
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 173 6e-42
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 173 6e-42
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 173 6e-42
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 173 6e-42
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 172 1e-41
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 172 1e-41
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 172 2e-41
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 171 3e-41
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 171 3e-41
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 171 3e-41
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 171 3e-41
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 171 4e-41
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 171 4e-41
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 171 4e-41
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 170 6e-41
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 170 6e-41
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 170 6e-41
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 170 8e-41
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 170 8e-41
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 170 8e-41
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 170 8e-41
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 169 1e-40
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 169 1e-40
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 169 1e-40
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 169 1e-40
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 169 1e-40
UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=... 169 1e-40
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 169 1e-40
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 169 2e-40
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 169 2e-40
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 169 2e-40
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 169 2e-40
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 168 2e-40
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 168 2e-40
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 168 3e-40
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 168 3e-40
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 167 4e-40
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 167 4e-40
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 167 4e-40
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 167 4e-40
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 167 6e-40
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 167 6e-40
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 167 7e-40
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 167 7e-40
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 166 1e-39
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 166 1e-39
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 166 1e-39
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 166 1e-39
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 166 1e-39
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 166 1e-39
UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor; ... 166 1e-39
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 165 2e-39
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 165 2e-39
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 165 2e-39
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 165 2e-39
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 165 2e-39
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 165 2e-39
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 165 2e-39
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 165 2e-39
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 165 2e-39
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 165 2e-39
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 165 3e-39
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 165 3e-39
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 164 4e-39
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 164 5e-39
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 164 5e-39
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 164 5e-39
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 163 7e-39
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 163 7e-39
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 163 7e-39
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 163 9e-39
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 163 1e-38
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 162 2e-38
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 162 2e-38
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 162 2e-38
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 162 2e-38
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 162 2e-38
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 161 3e-38
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 161 3e-38
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 161 3e-38
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 161 4e-38
UniRef50_Q613B1 Cluster: Putative uncharacterized protein CBG164... 161 4e-38
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 161 4e-38
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 161 5e-38
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 160 6e-38
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 160 6e-38
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 160 6e-38
UniRef50_Q19726 Cluster: Putative uncharacterized protein kin-14... 160 6e-38
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 160 8e-38
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 160 8e-38
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 160 8e-38
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 160 8e-38
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 160 8e-38
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 159 1e-37
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 159 1e-37
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 159 1e-37
UniRef50_Q18865 Cluster: Putative uncharacterized protein; n=5; ... 159 1e-37
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 159 1e-37
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 159 2e-37
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 159 2e-37
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 159 2e-37
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 158 3e-37
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 158 3e-37
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 158 3e-37
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 158 3e-37
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 158 3e-37
UniRef50_Q22765 Cluster: Putative uncharacterized protein; n=3; ... 158 3e-37
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 158 3e-37
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 158 3e-37
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 157 4e-37
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 157 4e-37
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 157 4e-37
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 157 4e-37
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 157 4e-37
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 157 6e-37
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 157 6e-37
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 157 6e-37
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 157 6e-37
UniRef50_O01325 Cluster: Putative uncharacterized protein; n=2; ... 157 6e-37
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 157 6e-37
UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core eu... 157 8e-37
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 157 8e-37
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 156 1e-36
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 156 1e-36
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 156 1e-36
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 155 2e-36
UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;... 155 2e-36
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 155 2e-36
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 155 2e-36
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 155 3e-36
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 154 4e-36
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 154 4e-36
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 154 4e-36
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 154 5e-36
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 154 5e-36
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 153 7e-36
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 153 1e-35
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 153 1e-35
UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1; n... 153 1e-35
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 153 1e-35
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 153 1e-35
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 153 1e-35
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 153 1e-35
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 152 2e-35
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 152 2e-35
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 152 2e-35
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 151 3e-35
UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep: EDR1... 151 4e-35
UniRef50_Q9XW34 Cluster: Putative uncharacterized protein; n=3; ... 151 4e-35
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 151 5e-35
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 151 5e-35
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 151 5e-35
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 150 7e-35
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 150 9e-35
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 150 9e-35
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 149 1e-34
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 149 1e-34
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 149 1e-34
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 149 1e-34
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 149 1e-34
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 149 1e-34
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 149 2e-34
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 149 2e-34
UniRef50_Q0IZJ5 Cluster: Os09g0566500 protein; n=9; Magnoliophyt... 149 2e-34
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 149 2e-34
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 149 2e-34
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 148 4e-34
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 148 4e-34
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 148 4e-34
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 147 5e-34
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 146 8e-34
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 146 8e-34
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 146 8e-34
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 146 1e-33
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 146 1e-33
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 146 1e-33
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 146 1e-33
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 145 2e-33
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 144 3e-33
UniRef50_Q9ZSD8 Cluster: Ethylene-inducible CTR1-like protein ki... 144 3e-33
UniRef50_P42159 Cluster: Class II receptor tyrosine kinase; n=5;... 144 3e-33
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 144 3e-33
UniRef50_UPI00015B4B9F Cluster: PREDICTED: similar to prenylcyst... 144 4e-33
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 144 4e-33
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 144 6e-33
UniRef50_Q9LYI8 Cluster: MAP3K delta-1 protein kinase; n=3; Arab... 144 6e-33
UniRef50_Q61B52 Cluster: Putative uncharacterized protein CBG134... 144 6e-33
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 144 6e-33
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 143 8e-33
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 143 1e-32
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 143 1e-32
UniRef50_Q9U3B5 Cluster: Putative uncharacterized protein; n=3; ... 143 1e-32
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 143 1e-32
UniRef50_Q9TYX4 Cluster: Putative uncharacterized protein R11E3.... 142 1e-32
UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1; Trichom... 142 1e-32
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 142 2e-32
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 142 2e-32
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 142 2e-32
UniRef50_Q94AB2 Cluster: AT3g58640/F14P22_230; n=13; Magnoliophy... 141 3e-32
UniRef50_Q6ER39 Cluster: CTR1-like kinase kinase kinase-like; n=... 141 3e-32
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 141 3e-32
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 141 4e-32
UniRef50_Q23102 Cluster: Putative uncharacterized protein; n=1; ... 141 4e-32
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 141 4e-32
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 141 4e-32
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 140 5e-32
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 140 7e-32
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 140 7e-32
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 140 7e-32
UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genom... 140 1e-31
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 140 1e-31
UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole gen... 139 1e-31
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 139 1e-31
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 139 1e-31
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 139 1e-31
UniRef50_Q01JS4 Cluster: OSIGBa0152L12.10 protein; n=4; Oryza sa... 139 2e-31
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 138 2e-31
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 138 3e-31
UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Or... 138 4e-31
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 138 4e-31
UniRef50_Q621U0 Cluster: Putative uncharacterized protein CBG023... 137 5e-31
UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin domain-cont... 137 7e-31
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 137 7e-31
UniRef50_UPI0000499A85 Cluster: protein kinase; n=1; Entamoeba h... 136 9e-31
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 136 9e-31
UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein;... 136 9e-31
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 136 1e-30
UniRef50_Q61CN6 Cluster: Putative uncharacterized protein CBG128... 136 2e-30
UniRef50_Q54TA1 Cluster: E set domain-containing protein; n=1; D... 136 2e-30
UniRef50_P11681 Cluster: Tyrosine-protein kinase ABL; n=2; Dipte... 136 2e-30
UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Tritic... 135 2e-30
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 135 2e-30
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 135 2e-30
UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1; Dictyos... 135 3e-30
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 134 4e-30
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 134 4e-30
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 134 4e-30
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 134 4e-30
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 134 4e-30
UniRef50_Q9SZM7 Cluster: Protein kinase like protein; n=1; Arabi... 134 6e-30
UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum lycopersicu... 134 6e-30
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 134 6e-30
UniRef50_Q6W5B1 Cluster: TEL/JAK2 fusion protein; n=4; Danio rer... 133 8e-30
UniRef50_A7RX97 Cluster: Predicted protein; n=1; Nematostella ve... 133 1e-29
UniRef50_A2DZZ0 Cluster: TKL family protein kinase; n=1; Trichom... 133 1e-29
UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1; Dictyos... 132 1e-29
UniRef50_Q9FGZ6 Cluster: Protein kinase; n=3; Arabidopsis thalia... 132 2e-29
UniRef50_Q9C547 Cluster: Protein kinase, putative; 12576-15979; ... 132 2e-29
UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole gen... 132 2e-29
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 132 2e-29
UniRef50_Q54RZ7 Cluster: MORN repeat-containing protein; n=1; Di... 132 2e-29
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 132 3e-29
UniRef50_A0D9Q7 Cluster: Chromosome undetermined scaffold_42, wh... 132 3e-29
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 131 3e-29
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 131 3e-29
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 131 3e-29
UniRef50_O43283 Cluster: Mitogen-activated protein kinase kinase... 131 3e-29
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 131 3e-29
UniRef50_P91360 Cluster: Putative uncharacterized protein; n=1; ... 131 4e-29
UniRef50_UPI00015B628A Cluster: PREDICTED: similar to LD14856p; ... 130 6e-29
UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine k... 130 8e-29
UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed line... 130 8e-29
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 130 8e-29
UniRef50_O17755 Cluster: Putative uncharacterized protein; n=3; ... 130 8e-29
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 130 8e-29
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 130 8e-29
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 130 1e-28
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 130 1e-28
UniRef50_A2DI38 Cluster: TKL family protein kinase; n=2; Trichom... 130 1e-28
UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=... 130 1e-28
UniRef50_UPI00015535B8 Cluster: PREDICTED: similar to mixed line... 129 1e-28
UniRef50_UPI0000DB7B8A Cluster: PREDICTED: similar to CG8789-PA,... 129 1e-28
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 129 1e-28
UniRef50_P80192 Cluster: Mitogen-activated protein kinase kinase... 129 1e-28
UniRef50_Q3U1V8 Cluster: Mitogen-activated protein kinase kinase... 129 2e-28
UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to mitogen-ac... 128 2e-28
UniRef50_Q9GZG1 Cluster: Putative uncharacterized protein; n=6; ... 128 2e-28
UniRef50_Q9BI25 Cluster: SHK1 protein; n=2; Dictyostelium discoi... 128 2e-28
UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;... 128 3e-28
UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677; ... 128 3e-28
UniRef50_Q8ITG6 Cluster: Focal adhesion kinase; n=2; Protostomia... 128 3e-28
UniRef50_Q5BXT3 Cluster: SJCHGC03955 protein; n=1; Schistosoma j... 128 3e-28
UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase... 128 3e-28
UniRef50_Q4S5N1 Cluster: Chromosome 9 SCAF14729, whole genome sh... 128 4e-28
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 128 4e-28
UniRef50_UPI0000585FA7 Cluster: PREDICTED: similar to leucine zi... 127 5e-28
UniRef50_Q4RVA1 Cluster: Chromosome 15 SCAF14992, whole genome s... 127 5e-28
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 127 5e-28
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 127 7e-28
UniRef50_Q27HR1 Cluster: Ret tyrosine-kinase receptor; n=1; Bran... 127 7e-28
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 127 7e-28
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 126 1e-27
UniRef50_Q03351 Cluster: NT-3 growth factor receptor precursor; ... 126 1e-27
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 126 1e-27
UniRef50_Q8T0Z7 Cluster: Tyrosine kinase-like protein; n=1; Bomb... 126 1e-27
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 126 1e-27
UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 126 1e-27
UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3; ... 126 2e-27
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 126 2e-27
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 125 2e-27
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 125 2e-27
UniRef50_Q4T1R9 Cluster: Chromosome 4 SCAF10492, whole genome sh... 125 3e-27
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 125 3e-27
UniRef50_Q019B0 Cluster: Tyrosine kinase specific for activated ... 125 3e-27
UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole gen... 125 3e-27
UniRef50_Q5CVX5 Cluster: Ser/Thr protein kinase with MORN repeat... 125 3e-27
UniRef50_Q13470 Cluster: Non-receptor tyrosine-protein kinase TN... 125 3e-27
UniRef50_Q02779 Cluster: Mitogen-activated protein kinase kinase... 125 3e-27
UniRef50_UPI00006CE4F4 Cluster: Protein kinase domain containing... 124 4e-27
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 124 4e-27
UniRef50_Q4H377 Cluster: Mitogen-activated protein kinase kinase... 124 4e-27
UniRef50_A0C299 Cluster: Chromosome undetermined scaffold_144, w... 124 4e-27
UniRef50_Q5TCX8 Cluster: Mitogen-activated protein kinase kinase... 124 4e-27
UniRef50_Q4S8H3 Cluster: Chromosome 2 SCAF14705, whole genome sh... 124 5e-27
UniRef50_Q4RHE1 Cluster: Chromosome 3 SCAF15050, whole genome sh... 124 5e-27
UniRef50_A2EGD0 Cluster: TKL family protein kinase; n=3; Trichom... 124 5e-27
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 124 5e-27
UniRef50_O15197 Cluster: Ephrin type-B receptor 6 precursor; n=2... 124 5e-27
UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1 ... 124 5e-27
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 124 7e-27
UniRef50_Q6J4P8 Cluster: Insulin-like receptor; n=2; Apis mellif... 124 7e-27
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 124 7e-27
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 123 9e-27
UniRef50_UPI0000D572D6 Cluster: PREDICTED: similar to CG2845-PA;... 123 9e-27
UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,... 123 9e-27
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 123 9e-27
UniRef50_A2FCV2 Cluster: TKL family protein kinase; n=1; Trichom... 123 9e-27
UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1; Trichom... 123 9e-27
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 123 9e-27
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 123 9e-27
UniRef50_O12990 Cluster: Tyrosine-protein kinase Jak1; n=8; Eute... 123 9e-27
UniRef50_UPI0000F1F986 Cluster: PREDICTED: similar to mixed line... 123 1e-26
UniRef50_UPI000049A16F Cluster: protein kinase; n=1; Entamoeba h... 123 1e-26
UniRef50_Q9STU7 Cluster: Putative uncharacterized protein T22A6.... 123 1e-26
UniRef50_Q55AN7 Cluster: SMAD/FHA domain-containing protein; n=2... 123 1e-26
UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA... 122 2e-26
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 122 2e-26
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 122 2e-26
UniRef50_Q4RX00 Cluster: Chromosome 11 SCAF14979, whole genome s... 122 2e-26
UniRef50_Q0IR49 Cluster: Os11g0678000 protein; n=7; Oryza sativa... 122 2e-26
UniRef50_Q0IPW2 Cluster: Os12g0163800 protein; n=7; Magnoliophyt... 122 2e-26
UniRef50_A4S4M0 Cluster: Predicted protein; n=1; Ostreococcus lu... 122 2e-26
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 122 2e-26
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 122 2e-26
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 122 2e-26
UniRef50_Q17HL3 Cluster: Discoidin domain receptor; n=3; Culicid... 122 3e-26
UniRef50_UPI000155F437 Cluster: PREDICTED: similar to Mitogen ac... 121 4e-26
UniRef50_A4S2A1 Cluster: Predicted protein; n=1; Ostreococcus lu... 121 4e-26
UniRef50_Q16584 Cluster: Mitogen-activated protein kinase kinase... 121 4e-26
UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (E... 121 5e-26
UniRef50_Q54IP4 Cluster: SH2 domain-containing protein; n=1; Dic... 121 5e-26
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 121 5e-26
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 121 5e-26
UniRef50_Q96Q04 Cluster: Serine/threonine-protein kinase LMTK3 p... 121 5e-26
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 120 6e-26
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 120 6e-26
UniRef50_Q9VW24 Cluster: CG8789-PA, isoform A; n=3; Diptera|Rep:... 120 6e-26
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 120 6e-26
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 120 6e-26
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 120 8e-26
UniRef50_Q4RU24 Cluster: Chromosome 12 SCAF14996, whole genome s... 120 8e-26
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 120 8e-26
UniRef50_A0CL90 Cluster: Chromosome undetermined scaffold_20, wh... 120 8e-26
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 779 bits (1927), Expect = 0.0
Identities = 365/413 (88%), Positives = 390/413 (94%), Gaps = 3/413 (0%)
Query: 52 SANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAH 111
+ANRWTSKENLLA EEDDPQLFVALYDFQAGGENQL+LKKGEQVRI+SYNKSGEWCEAH
Sbjct: 91 AANRWTSKENLLAQ-EEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAH 149
Query: 112 TLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRS 171
+ TG VGWVPSNYVTPVNSLEKHSWYHG I RNAAEYLLSSGINGSFLVRESESSPGQRS
Sbjct: 150 SSTGQVGWVPSNYVTPVNSLEKHSWYHGRICRNAAEYLLSSGINGSFLVRESESSPGQRS 209
Query: 172 ISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK 231
ISLRYEGRVYHYRINED++GK++VT+ESKF TLAELVHHHS+ DGLITQLLYPAPK +K
Sbjct: 210 ISLRYEGRVYHYRINEDSEGKMFVTTESKFNTLAELVHHHSMLADGLITQLLYPAPKHNK 269
Query: 232 PTVFPLAP-PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKD 290
PTVFPL+P PD WEI+RTDIVM+HKLGGGQYGDVYEA WKR N+TVAVKTLK+DTMALKD
Sbjct: 270 PTVFPLSPEPDEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKD 329
Query: 291 FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLM 350
FLEEA+IMKEM+H NLVQLLGVCTREPPFYIITEFMS+GNLL+YLR ++ + AVVLM
Sbjct: 330 FLEEAAIMKEMKHRNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRNESKHQI-NAVVLM 388
Query: 351 YMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKF 410
+MATQIASGMSYLESR+FIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKF
Sbjct: 389 HMATQIASGMSYLESRNFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKF 448
Query: 411 PIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PIKWTAPEGLAYN FSTKSDVWAFGILLWEIATYGMSPYPGVDL DVYHMLEK
Sbjct: 449 PIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEK 501
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 778 bits (1923), Expect = 0.0
Identities = 365/413 (88%), Positives = 390/413 (94%), Gaps = 3/413 (0%)
Query: 52 SANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAH 111
+ANRWTSKENLLA EEDDPQLFVALYDFQAGGENQL LKKGEQVRI+SYNKSGEWCEAH
Sbjct: 92 AANRWTSKENLLAQ-EEDDPQLFVALYDFQAGGENQLGLKKGEQVRILSYNKSGEWCEAH 150
Query: 112 TLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRS 171
+ +G VGWVPSNYVTPVNSLEKHSWYHG ISRNAAEYLLSSGINGSFLVRESESSPGQRS
Sbjct: 151 SSSGQVGWVPSNYVTPVNSLEKHSWYHGRISRNAAEYLLSSGINGSFLVRESESSPGQRS 210
Query: 172 ISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK 231
ISLRYEGRVYHYRINED+DGK+YVT+ES F TLAELVHHHS+ DGLITQLLYPAPKR+K
Sbjct: 211 ISLRYEGRVYHYRINEDSDGKMYVTTESIFNTLAELVHHHSMLADGLITQLLYPAPKRNK 270
Query: 232 PTVFPLAP-PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKD 290
PTVFPL+P PD WEI+RTDIVM+HKLGGGQYGDVYEA WKR N+TVAVKTLK+DTMALKD
Sbjct: 271 PTVFPLSPEPDEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKD 330
Query: 291 FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLM 350
FLEEA+IMKEM+H NLVQL+GVCTREPPFYIITEFMS+GNLL+YLR ++ + AVVLM
Sbjct: 331 FLEEAAIMKEMKHRNLVQLIGVCTREPPFYIITEFMSKGNLLDYLRNESKHQI-NAVVLM 389
Query: 351 YMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKF 410
+MATQIASGMSYLESR+FIHRDLAARNCLVGE+HLVKVADFGLARLMRDDTYTAHAGAKF
Sbjct: 390 HMATQIASGMSYLESRNFIHRDLAARNCLVGESHLVKVADFGLARLMRDDTYTAHAGAKF 449
Query: 411 PIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PIKWTAPEGLAYN FSTKSDVWAFGILLWEIATYGMSPYPGVDL DVYHMLEK
Sbjct: 450 PIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEK 502
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 754 bits (1865), Expect = 0.0
Identities = 355/416 (85%), Positives = 384/416 (92%), Gaps = 5/416 (1%)
Query: 52 SANRWTSKENLLAHH-EEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEA 110
SA+RWTSKENLLA EEDDPQLFVALYDFQAGGENQL+LKKGEQVRI+SYNKSGEWCEA
Sbjct: 169 SAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEA 228
Query: 111 HTLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR 170
H+ +G VGWVPSNYVTP+NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR
Sbjct: 229 HSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR 288
Query: 171 SISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSV--AGDGLITQLLYPAPK 228
SISLRYEGRVYHYRI+ED DGKV+VT E+KF TLAELVHHHSV G GLIT LLYPAPK
Sbjct: 289 SISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPK 348
Query: 229 RSKPTVFPLAP-PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMA 287
++KPTVFPL+P PD WEI RTDI+MKHKLGGGQYG+VYEA WKR TVAVKTLK+DTMA
Sbjct: 349 QNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMA 408
Query: 288 LKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAV 347
LKDFLEEA+IMKEM+HPNLVQL+GVCTREPPFYIITEFMS GNLL++LR+ RE + AV
Sbjct: 409 LKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETL-DAV 467
Query: 348 VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAG 407
L+YMATQIASGMSYLESR++IHRDLAARNCLVG+N LVKVADFGLARLMRDDTYTAHAG
Sbjct: 468 ALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAG 527
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
AKFPIKWTAPEGLAYN FSTKSDVWAFG+LLWEIATYGMSPYP +DL DVYH L+K
Sbjct: 528 AKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDK 583
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 686 bits (1696), Expect = 0.0
Identities = 315/412 (76%), Positives = 361/412 (87%), Gaps = 3/412 (0%)
Query: 53 ANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHT 112
A RW SKENLLA E+DP LFVALYDF A G+N L++ KGE++R++ YN +GEWCEA T
Sbjct: 45 AARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT 104
Query: 113 LTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSI 172
G GWVPSNY+TPVNSLEKHSWYHGP+SRNAAEYLLSSGINGSFLVRESESSPGQRSI
Sbjct: 105 KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSI 163
Query: 173 SLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKP 232
SLRYEGRVYHYRIN +DGK+YV+SES+F TLAELVHHHS DGLIT L YPAPKR+KP
Sbjct: 164 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 223
Query: 233 TVFPLAPP-DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDF 291
TV+ ++P D WE++RTDI MKHKLGGGQYG+VYE WK+ ++TVAVKTLK+DTM +++F
Sbjct: 224 TVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 283
Query: 292 LEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMY 351
L+EA++MKE++HPNLVQLLGVCTREPPFYIITEFM+ GNLL+YLR R+ V AVVL+Y
Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV-NAVVLLY 342
Query: 352 MATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFP 411
MATQI+S M YLE ++FIHRDLAARNCLVGENHLVKVADFGL+RLM DTYTAHAGAKFP
Sbjct: 343 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 402
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
IKWTAPE LAYN FS KSDVWAFG+LLWEIATYGMSPYPG+DL+ VY +LEK
Sbjct: 403 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 454
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 672 bits (1660), Expect = 0.0
Identities = 308/405 (76%), Positives = 354/405 (87%), Gaps = 3/405 (0%)
Query: 60 ENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGW 119
ENLLA E+DP LFVALYDF A G+N L++ KGE++R++ YN +GEWCEA T G GW
Sbjct: 1 ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GW 59
Query: 120 VPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGR 179
VPSNY+TPVNSLEKHSWYHGP+SRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGR
Sbjct: 60 VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGR 119
Query: 180 VYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAP 239
VYHYRIN +DGK+YV+ ES+F TLAELVHHHS DGLIT L YPAPKR+KPTV+ ++P
Sbjct: 120 VYHYRINTASDGKLYVSPESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP 179
Query: 240 P-DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIM 298
D WE++RTDI MKHKLGGGQYG+VYE WK+ ++TVAVKTLK+DTM +++FL+EA++M
Sbjct: 180 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 239
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
KE++HPNLVQLLGVCTREPPFYIITEFM+ GNLL+YLR R+ V AVVL+YMATQI+S
Sbjct: 240 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV-NAVVLLYMATQISS 298
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPE 418
M YLE ++FIHRDLAARNCLVGENHLVKVADFGL+RLM DTYTAHAG KFPIKWTAPE
Sbjct: 299 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPE 358
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
LAYN FS KSDVWAFG+LLWEIATYGMSPYPG+DL+ VY +LEK
Sbjct: 359 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 403
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 658 bits (1626), Expect = 0.0
Identities = 305/412 (74%), Positives = 354/412 (85%), Gaps = 4/412 (0%)
Query: 53 ANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHT 112
A RW+SKENLL E DP LFVALYDF A G+N L++ KGE++R++ YN++GEW E +
Sbjct: 92 AIRWSSKENLLGA-TESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS 150
Query: 113 LTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSI 172
G GWVPSNY+TPVNSLEKHSWYHGP+SR+AAEYLLSS INGSFLVRESESSPGQ SI
Sbjct: 151 KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSI 209
Query: 173 SLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKP 232
SLRYEGRVYHYRIN ADGKVYVT+ES+F TLAELVHHHS DGL+T L YPAPK +KP
Sbjct: 210 SLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP 269
Query: 233 TVFPLAP-PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDF 291
TV+ ++P D WE++RTDI MKHKLGGGQYG+VY WK+ ++TVAVKTLK+DTM +++F
Sbjct: 270 TVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEF 329
Query: 292 LEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMY 351
L+EA++MKE++HPNLVQLLGVCT EPPFYI+TE+M GNLL+YLR RE V AVVL+Y
Sbjct: 330 LKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT-AVVLLY 388
Query: 352 MATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFP 411
MATQI+S M YLE ++FIHRDLAARNCLVGENH+VKVADFGL+RLM DTYTAHAGAKFP
Sbjct: 389 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFP 448
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
IKWTAPE LAYNTFS KSDVWAFG+LLWEIATYGMSPYPG+DL+ VY +LEK
Sbjct: 449 IKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 588 bits (1452), Expect = e-166
Identities = 269/341 (78%), Positives = 307/341 (90%), Gaps = 2/341 (0%)
Query: 124 YVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 183
Y+TPVNSLEKHSWYHGP+SRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
Sbjct: 1 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 60
Query: 184 RINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPP-DH 242
RIN +DGK+YV+SES+F TLAELVHHHS DGLIT L YPAPKR+KPT++ ++P D
Sbjct: 61 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK 120
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMR 302
WE++RTDI MKHKLGGGQYG+VYE WK+ ++TVAVKTLK+DTM +++FL+EA++MKE++
Sbjct: 121 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 180
Query: 303 HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSY 362
HPNLVQLLGVCTREPPFYIITEFM+ GNLL+YLR R+ V AVVL+YMATQI+S M Y
Sbjct: 181 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV-SAVVLLYMATQISSAMEY 239
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAY 422
LE ++FIHRDLAARNCLVGENHLVKVADFGL+RLM DTYTAHAGAKFPIKWTAPE LAY
Sbjct: 240 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 299
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
N FS KSDVWAFG+LLWEIATYGMSPYPG+DL+ VY +LEK
Sbjct: 300 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 340
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 565 bits (1395), Expect = e-160
Identities = 264/417 (63%), Positives = 328/417 (78%), Gaps = 16/417 (3%)
Query: 61 NLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLT------ 114
N ++ LFVALYDF GE QL+L+KG+QVRI+ YNK+ EWCEA +
Sbjct: 107 NTVSSSSSSSAPLFVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDA 166
Query: 115 ------GAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 168
G +GWVPSN++ P NSL+K++WYHG ISR+ +E +L SGI GSFLVRESE+S G
Sbjct: 167 SNQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIG 226
Query: 169 QRSISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPK 228
Q +IS+R++GRV+HYRIN D K+++T E KF TL ELVHHHSV DGLI L+YPA K
Sbjct: 227 QYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASK 286
Query: 229 RSKPT-VFPLAP--PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDT 285
+ K +F L+P PD WE+DR++I+M +KLGGGQYGDVYE WKR + T+AVK LK+D
Sbjct: 287 KDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDA 346
Query: 286 MALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG 345
M L +FL EA+IMK++ H NLV+LLGVCT E PFYIITEFM GNLLEYLR + +P
Sbjct: 347 MPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLP- 405
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAH 405
++L+ MA+QIASGMSYLE+R FIHRDLAARNCLV E+++VK+ADFGLAR M++DTYTAH
Sbjct: 406 PIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAH 465
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
AGAKFPIKWTAPEGLA+NTFS+KSDVWAFG+LLWEIATYGM+PYPGV+L++VY +LE
Sbjct: 466 AGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLE 522
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 386 bits (950), Expect = e-106
Identities = 188/396 (47%), Positives = 264/396 (66%), Gaps = 8/396 (2%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEW-CEAHTLTGAVGWVPSNYVTPVNSL 131
++V YD+ + ++ L+ KKG+ + I+S ++ W + G G++PSNYV SL
Sbjct: 58 IYVGKYDYDSRTDDDLSFKKGDLMYIISTDEGDWWFARSKDTAGKEGYIPSNYVAEYKSL 117
Query: 132 EKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINEDA 189
+ W+ G I R AE +L+ N GSFL+R+SE++PG S+S++ + RV HYR+
Sbjct: 118 DAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRLE 177
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPP--DHWEIDR 247
DG ++VT S F L ELV H+ + DGL +LLYP + KP L + WEI++
Sbjct: 178 DGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQANEEWEIEK 237
Query: 248 TDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLV 307
T I + +LG GQ+G+V+E W G +VAVKTLK TM++++FL+EASIMK +RHP L+
Sbjct: 238 TQIKLLRRLGAGQFGEVWEGLWN-GTTSVAVKTLKPGTMSVEEFLQEASIMKRLRHPKLI 296
Query: 308 QLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRS 367
QL VCT+E P YI+TE M G+LLEYLR + V L+ +A Q+ASGMSYLE ++
Sbjct: 297 QLYAVCTKEEPIYIVTELMKYGSLLEYLRG--EDGVLKIEQLVDVAAQVASGMSYLEQQN 354
Query: 368 FIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFST 427
+IHRDLAARN LVGE+ + KVADFGLAR++ ++ Y AH GAKFPIKWTAPE YN F+
Sbjct: 355 YIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTI 414
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
KSDVW+FG++L+EI TYG PYPG+ +V +++
Sbjct: 415 KSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQQ 450
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 347 bits (854), Expect = 3e-94
Identities = 181/399 (45%), Positives = 249/399 (62%), Gaps = 12/399 (3%)
Query: 74 FVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEK 133
FVAL+D+ ++ L + KG+ I+ + W TG G+VP N++ V SLE
Sbjct: 160 FVALHDYVKRVDDDLNMTKGQIFNILDNSHCDWWYAECVSTGNRGYVPKNHLAAVTSLES 219
Query: 134 HSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRIN----- 186
+ WY G + R AE+ L N GSFLVR SES + S+S+R E V HYRI
Sbjct: 220 NEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIRSRYSR 279
Query: 187 -EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPP--DHW 243
+ + Y++ + F + +LV+H+ GL +L P + + P L+ D W
Sbjct: 280 TDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEPVGLSHKLIDKW 339
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRH 303
EI ++ I++K K+G GQ+G+V++A W + I VAVKTLK + DFL EA MK + H
Sbjct: 340 EIPKSSIILKEKIGQGQFGEVFKAVWNKTTI-VAVKTLKPSSCDAADFLREAQTMKRLHH 398
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
PNL+QL VCT+ PFYI+TE+MS+G+LL YL++ + ++M MA +IA GM+YL
Sbjct: 399 PNLIQLYAVCTQTEPFYIVTEYMSKGSLLNYLQSPEGNALNMQCLIM-MAAKIAPGMAYL 457
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYN 423
ESR IHRDLAARN LVGE H VK+ADFGLAR++ + Y AHAGA+FPIKWT+PE Y+
Sbjct: 458 ESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHNREYVAHAGARFPIKWTSPEAANYS 517
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
F+ KSDVW+FGILL EI TYG SPYPG+ A+V ++
Sbjct: 518 RFTIKSDVWSFGILLTEIVTYGRSPYPGMHNAEVLRQVD 556
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase
Yes; n=422; root|Rep: Proto-oncogene tyrosine-protein
kinase Yes - Homo sapiens (Human)
Length = 543
Score = 342 bits (841), Expect = 1e-92
Identities = 187/399 (46%), Positives = 256/399 (64%), Gaps = 14/399 (3%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL-TGAVGWVPSNYVTPVNSL 131
+FVALYD++A L+ KKGE+ +I++ N G+W EA ++ TG G++PSNYV P +S+
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
Query: 132 EKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR----YEG-RVYHYR 184
+ WY G + R AE LL + N G FLVRESE++ G S+S+R G V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWE 244
I + +G Y+T+ ++F TL +LV H++ DGL +L P KP LA D WE
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPT-VKPQTQGLAK-DAWE 271
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
I R + ++ KLG G +G+V+ W G VA+KTLK TM + FL+EA IMK++RH
Sbjct: 272 IPRESLRLEVKLGQGCFGEVWMGTWN-GTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHD 330
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
LV L V + EP YI+TEFMS+G+LL++L+ G + + L+ MA QIA GM+Y+E
Sbjct: 331 KLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLK-LPQLVDMAAQIADGMAYIE 388
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNT 424
++IHRDL A N LVGEN + K+ADFGLARL+ D+ YTA GAKFPIKWTAPE Y
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
Query: 425 FSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
F+ KSDVW+FGIL E+ T G PYPG+ +V +E+
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER 487
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 341 bits (837), Expect = 3e-92
Identities = 186/407 (45%), Positives = 250/407 (61%), Gaps = 20/407 (4%)
Query: 72 QLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSL 131
+ VALY + + + L+ +KG+ + ++ ++ W H TG G+VP N+V ++
Sbjct: 74 ETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTI 133
Query: 132 EKHSWYHGPISRNAAEYL-LSSGI-NGSFLVRESESSPGQRSISLRYE------GRVYHY 183
E WY G I RN AE L LSS + G+FL+RE E+ + ++++R G V HY
Sbjct: 134 ESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHY 193
Query: 184 RINE-DADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLA--PP 240
+I D D ++T+ F +L ELV ++S DGL QL +PAP R PT L+
Sbjct: 194 KIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAP-RLAPTRPDLSHDTQ 252
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKE 300
+WEI R + +K KLG G +G+V+ W RG + VA+KT+K TM+ + FL+EA IMK+
Sbjct: 253 QNWEIPRNQLHLKRKLGDGNFGEVWYGKW-RGIVEVAIKTMKPGTMSPEAFLQEAQIMKQ 311
Query: 301 MRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGM 360
HPNLV+L VCTRE PFYIITE+M G+LL+YLR G L+ MA QIA+GM
Sbjct: 312 CDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTL--GIQALVDMAAQIANGM 369
Query: 361 SYLESRSFIHRDLAARNCLVGEN----HLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWT 415
YLE R +HRDLAARN LVG+ +VKVADFGLAR LM +D Y A GAKFPIKWT
Sbjct: 370 MYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWT 429
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
APE F+ KSDVW++GILL+EI T G PYPG+ +V +E
Sbjct: 430 APEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVE 476
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 336 bits (827), Expect = 5e-91
Identities = 184/402 (45%), Positives = 239/402 (59%), Gaps = 16/402 (3%)
Query: 74 FVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAH-------TLTGAVGWVPSNYVT 126
FVAL+D+QA L+ + G++++++ G W H + G++PSNYV
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 127 PVNSLEKHSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 184
SL+ W+ G I R+ AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLA--PPDH 242
I +G ++T F TL E V H++ DGL +L P K P F L+ D
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMR 302
WEIDR I + +LG GQ+G+V+E W VAVKTLK +M DFL EA IMK +R
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
Query: 303 HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSY 362
HP L+QL VCT E P YIITE M G+L EYL+ + + MA Q+ASGM+Y
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKI-HLTQQVDMAAQVASGMAY 344
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR---DDTYTAHAGAKFPIKWTAPEG 419
LESR++IHRDLAARN LVGE+++ KVADFGLAR+ + +D Y + K P+KWTAPE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 420 LAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
+ N FS KSDVW+FGILL+EI TYG PY G+ A V ML
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQML 446
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 332 bits (816), Expect = 1e-89
Identities = 168/379 (44%), Positives = 235/379 (62%), Gaps = 9/379 (2%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKH 134
+A+YD+ L L KG++V + + W A G+ G++PSNYV + L+
Sbjct: 259 IAMYDYPGLERGDLPLVKGQRVTVFDATREF-WWRARDEQGSEGYIPSNYVKKMG-LDSE 316
Query: 135 SWYHGPISRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
W+ +SR AE +L G G F+VR S S ++S+ +EG+V HY I D K
Sbjct: 317 EWFFPQLSRTRAENILKGEGREGGFVVRNS-SRENMYTLSICHEGQVRHYHIKLDESNKY 375
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAP--PDHWEIDRTDIV 251
+++ + +F ++ EL+ +H + G GL+T+L P P + P L P + WEID+ +
Sbjct: 376 FISEKHRFPSIKELIEYHKLNGGGLVTRLRKP-PVQLAPNPQSLGPLFDEAWEIDKVSLS 434
Query: 252 MKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLG 311
+ +LG GQ+G V WK G I VA+K +++ M DF+EEA +MK+ +H NLV+L G
Sbjct: 435 LGKELGSGQFGRVVSGKWK-GKIDVAIKMMREGAMNEDDFIEEAKVMKQFQHENLVKLYG 493
Query: 312 VCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHR 371
VCT+ P +I+ E M G LL++LR +E V +++ MATQI S M YLE FIHR
Sbjct: 494 VCTKNGPIFIVQELMVNGCLLQFLRQ-RKELVEKTEIILDMATQICSAMKYLEESGFIHR 552
Query: 372 DLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDV 431
DLAARNCLVGE ++VKVADFGLAR + DD YTA G KFPIKW APE + + FS+KSDV
Sbjct: 553 DLAARNCLVGERNVVKVADFGLARFVVDDEYTASEGTKFPIKWAAPEVITHAKFSSKSDV 612
Query: 432 WAFGILLWEIATYGMSPYP 450
W+FGILLWE+ T G +PYP
Sbjct: 613 WSFGILLWELWTGGKTPYP 631
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 331 bits (814), Expect = 2e-89
Identities = 182/401 (45%), Positives = 266/401 (66%), Gaps = 20/401 (4%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL-TGAVGWVPSNYVTPVNSL 131
+ VALYD++A L+ +KG+Q+ ++ +SGEW +A +L T G++PSNYV V+SL
Sbjct: 82 IVVALYDYEAIHHEDLSFQKGDQMVVLE--ESGEWWKARSLATRKEGYIPSNYVARVDSL 139
Query: 132 EKHSWYHGPISRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR-YEGR----VYHYR 184
E W+ ISR AE LL+ G + GSF++R+SE++ G S+S+R Y+ R V HY+
Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWE 244
I +G Y++ S F TL ELV H+ DGL +L P SKP P D WE
Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMS-SKPQK-PWEK-DAWE 256
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
I R + ++ KLG GQ+G+V+ A + + + VAVKT+K +M+++ FL EA++MK ++H
Sbjct: 257 IPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSVEAFLAEANVMKTLQHD 315
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--GARECVPGAVVLMYMATQIASGMSY 362
LV+L V T+EP YIITEFM++G+LL++L++ G+++ +P L+ + QIA GM++
Sbjct: 316 KLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPK---LIDFSAQIAEGMAF 371
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAY 422
+E R++IHRDL A N LV + + K+ADFGLAR++ D+ YTA GAKFPIKWTAPE + +
Sbjct: 372 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 431
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+F+ KSDVW+FGILL EI TYG PYPG+ +V LE+
Sbjct: 432 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER 472
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 331 bits (813), Expect = 3e-89
Identities = 177/387 (45%), Positives = 245/387 (63%), Gaps = 14/387 (3%)
Query: 74 FVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEK 133
+ ALYD++A + LT +KGE + I + W LT G+VP NY+ P + L+
Sbjct: 121 YKALYDYEARTADDLTFRKGEILIITNKTDPNWWLATSMLTKREGYVPRNYIEPADVLQA 180
Query: 134 HSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL--RYEGR---VYHYRIN 186
W+ ++R AE L N G+FL+R SE+SPG S+S+ + R V HYRI
Sbjct: 181 EDWFFEKMTRKEAEKQLQLAGNSRGTFLIRGSETSPGAYSLSVLDHDDARGFNVKHYRIR 240
Query: 187 E-DADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEI 245
D DG Y+++ F TL +LV+H++ DGL+ +LL P P R KP +F ++ D WEI
Sbjct: 241 TLDNDG-YYISTRITFHTLHDLVNHYTSQADGLVCRLLNPCP-RQKPVMFEISK-DVWEI 297
Query: 246 DRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPN 305
R I ++ KLG GQ+G+V+E W G + VAVKTLK+ M FL+EA+IMK++RHP
Sbjct: 298 PRRSIKLERKLGNGQFGEVWEGTWN-GTVRVAVKTLKEGAMDPTAFLQEANIMKKLRHPK 356
Query: 306 LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLES 365
LV LL VC+ P YI+TE M+ G LL+YL G + + L+ + Q+A GM+YLES
Sbjct: 357 LVALLAVCSEGEPIYIVTELMTNGCLLDYLHEGEGKQL-REPELIDITAQVADGMAYLES 415
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTF 425
+ F+HRDLAARN LVG+ KVADFGL+R++ D+ Y A GAK PIKWTAPE + + F
Sbjct: 416 QRFVHRDLAARNILVGDLRNCKVADFGLSRIIEDE-YIAKEGAKMPIKWTAPEAINFGKF 474
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGV 452
+ KSDVW+FGIL++E+ T G PYPG+
Sbjct: 475 TIKSDVWSFGILIYEVITKGRVPYPGM 501
>UniRef50_A2RQD6 Cluster: Bcr-abl1 e6a2 chimeric protein; n=10;
Euteleostomi|Rep: Bcr-abl1 e6a2 chimeric protein - Homo
sapiens (Human)
Length = 585
Score = 330 bits (812), Expect = 4e-89
Identities = 151/203 (74%), Positives = 173/203 (85%), Gaps = 2/203 (0%)
Query: 53 ANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHT 112
A RW SKE+LLA E+DP LFVALYDF A G+N L++ KGE++R++ YN +GEWCEA T
Sbjct: 384 AARWNSKEDLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT 443
Query: 113 LTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSI 172
G GWVPSNY+TPVNSLEKHSWYHGP+SRNAAEYLLSSGINGSFLVRESESSPGQRSI
Sbjct: 444 KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSI 502
Query: 173 SLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKP 232
SLRYEGRVYHYRIN +DGK+YV+SES+F TLAELVHHHS DGLIT L YPAPKR+KP
Sbjct: 503 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 562
Query: 233 TVFPLAPP-DHWEIDRTDIVMKH 254
TV+ ++P D WE++RTDI MKH
Sbjct: 563 TVYGVSPNYDKWEMERTDITMKH 585
>UniRef50_A2RQD7 Cluster: Bcr-abl1 e19a2 chimeric protein; n=2; Homo
sapiens|Rep: Bcr-abl1 e19a2 chimeric protein - Homo
sapiens (Human)
Length = 498
Score = 329 bits (808), Expect = 1e-88
Identities = 150/203 (73%), Positives = 173/203 (85%), Gaps = 2/203 (0%)
Query: 53 ANRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHT 112
A RW SKENLLA E+DP LFVALYDF A G+N L++ KGE++R++ YN +GEWCEA T
Sbjct: 297 AARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT 356
Query: 113 LTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSI 172
G GWVPSNY+TPVNSLEKHSWYHGP+SRNAAE+LLSSGINGSFLVRESESSPGQRSI
Sbjct: 357 KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEHLLSSGINGSFLVRESESSPGQRSI 415
Query: 173 SLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKP 232
SLRYEGRVYHYRIN +DGK+YV+SES+F TLAELVHHHS DGLIT L YPAPKR+KP
Sbjct: 416 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 475
Query: 233 TVFPLAPP-DHWEIDRTDIVMKH 254
+V+ ++P D WE++RTDI MKH
Sbjct: 476 SVYGVSPNYDKWEMERTDITMKH 498
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 327 bits (804), Expect = 3e-88
Identities = 172/401 (42%), Positives = 251/401 (62%), Gaps = 12/401 (2%)
Query: 72 QLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSL 131
++ VALYD+++ E+ L+ KG+++ ++ +S W + T G +P N+V S+
Sbjct: 98 RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV 157
Query: 132 EKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR--YEGRVYH---YR 184
W+ + R A+ LL + N G+FLVR SE +P S+S++ +GR YH YR
Sbjct: 158 NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYR 217
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPP--DH 242
I +G Y+ + F +L LV +S GL L P PK +P ++ L P D
Sbjct: 218 IKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPK-PQPQMWDLGPELRDK 276
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMR 302
+EI R++I + KLG G +G+V+ W R +I VAVKTL++ TM+ FL+EA+IMK+ R
Sbjct: 277 YEIPRSEIQLLRKLGRGNFGEVFYGKW-RNSIDVAVKTLREGTMSTAAFLQEAAIMKKFR 335
Query: 303 HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSY 362
H LV L VC++E P YI+ E+MS+G+LL++LR G + L+Y+ATQ+ASGM Y
Sbjct: 336 HNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFED-LIYIATQVASGMEY 394
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAY 422
LES+ IHRDLAARN L+GEN++ K+ DFGLAR++ DD Y G++FP+KWTAPE + Y
Sbjct: 395 LESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIY 454
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
FS KSDVW++GILL E+ TYG PYPG+ +V +E+
Sbjct: 455 GKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIER 495
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 325 bits (798), Expect = 2e-87
Identities = 173/406 (42%), Positives = 259/406 (63%), Gaps = 19/406 (4%)
Query: 68 EDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAV-GWVPSNYVT 126
E+ ++ VALY ++A + L KKGE+++I+ + GEW +A +LT G++PSNYV
Sbjct: 60 EEKEKIVVALYPYEAIHADDLGFKKGEKLKIIE--EHGEWWKARSLTTRKEGFIPSNYVA 117
Query: 127 PVNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-- 179
+++E W++ I+R AE L + N GS+L+RESE+S G S+S+R +G+
Sbjct: 118 EADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDV 177
Query: 180 VYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQL--LYPAPKRSKPTVFPL 237
V HY+I +G Y++ + F ++ ++ H+ DGL +L PK KP
Sbjct: 178 VKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPW---- 233
Query: 238 APPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASI 297
D WEI + I M KLG GQ+G+V+ A + VAVKTLK TM+++ FLEEA++
Sbjct: 234 -DKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNST-KVAVKTLKPGTMSVEAFLEEANL 291
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
MK ++H LV+L V T+ P YIITE+M+ G+LL++L++ A + ++ + A QIA
Sbjct: 292 MKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSA-QIA 350
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAP 417
GM+Y+E +++IHRDL A N LV E L K+ADFGLAR++ DD YTA GAKFPIKWTAP
Sbjct: 351 EGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAP 410
Query: 418 EGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
E + Y +F+ KSD+W+FG+LL+EI TYG PYPG+ ++V +++
Sbjct: 411 EAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQR 456
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 323 bits (794), Expect = 5e-87
Identities = 168/398 (42%), Positives = 245/398 (61%), Gaps = 10/398 (2%)
Query: 72 QLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTP--VN 129
+L VALY F+A L+L+K + ++ ++ W + G VG++PSNYV P +
Sbjct: 345 KLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKPKALL 403
Query: 130 SLEKHSWYHGPISRNAAEYLLSSGIN-GSFLVRESESSPGQRSISLRY---EGRVYHYRI 185
LE++ WY G +SR AE LL G G F+VR+S S+ G ++SL + V HY I
Sbjct: 404 GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHI 462
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEI 245
++A + Y++ + T+ +L+++H GL +L R P L+ D WEI
Sbjct: 463 KQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSH-DKWEI 521
Query: 246 DRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPN 305
++++ +LG GQ+G V W RG+I AVK +K+ TM+ DF+EEA +M +++HPN
Sbjct: 522 HPMELMLMEELGSGQFGVVRRGKW-RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPN 580
Query: 306 LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLES 365
LVQL GVC++ P YI+TE+M G+LL YLR + + +L+ M Q++ GM+YLE
Sbjct: 581 LVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLER 640
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTF 425
++IHRDLAARNCLVG ++VKVADFGLAR + DD YT+ G KFPIKW PE L Y F
Sbjct: 641 HNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRF 700
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
S+KSDVWA+G+L+WEI T G PY + +V +++
Sbjct: 701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQR 738
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 319 bits (784), Expect = 9e-86
Identities = 177/407 (43%), Positives = 244/407 (59%), Gaps = 22/407 (5%)
Query: 71 PQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNS 130
P+ +VAL+D+ A E + L + ++V +++ S W + +G G+VPS++V S
Sbjct: 114 PKHYVALFDYNARTEEETFLSRRDEVLLLADTDSEWWLVQNLSSGRKGYVPSSFVAKKGS 173
Query: 131 LEKHSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGR--------V 180
+E W+ +SR +E LL G FLVRESE+S G ++S+R E R V
Sbjct: 174 VEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTV 233
Query: 181 YHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQL----LYPAPKRSKPTVFP 236
HYRI Y+T++ F +L EL+ +S+ GL +L L P P S +V
Sbjct: 234 KHYRIKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCKLTRACLCPPPITSDLSV-- 291
Query: 237 LAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEAS 296
DHWEI ++ IV+ KLG GQ+G+V++ W G VAVKTLK TM +DFL+EA
Sbjct: 292 -KTKDHWEISKSSIVLIEKLGAGQFGEVWKGTWN-GTTEVAVKTLKQGTMTKEDFLKEAR 349
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
IM+ +HP LV+L VCT E P YI+TE M G+LL+YLR G + + L+ M QI
Sbjct: 350 IMRAAQHPKLVRLYAVCT-EDPIYIVTELMCNGSLLQYLRDGPGKNLL-INQLVDMMAQI 407
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD--TYTAHAGAKFPIKW 414
A+GM+YLE +IHRDLAARN LVGEN+ VKVADFGLAR++ D TY A KFPIKW
Sbjct: 408 ANGMAYLEKEHYIHRDLAARNILVGENNCVKVADFGLARMVEDHYCTYMAQKSTKFPIKW 467
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
TAPE F+ KSDVW+FGI+++E+ T G PYP ++ + H +
Sbjct: 468 TAPEAALMGRFTIKSDVWSFGIVIYELITLGQVPYPSMNNTETLHQV 514
>UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase BLK - Homo
sapiens (Human)
Length = 505
Score = 318 bits (782), Expect = 2e-85
Identities = 178/407 (43%), Positives = 255/407 (62%), Gaps = 20/407 (4%)
Query: 66 HEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL-TGAVGWVPSNY 124
H ++D VALYD+ A + L + KGE+++++ +G+W A +L TG G+VPSN+
Sbjct: 55 HLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLK--GTGDWWLARSLVTGREGYVPSNF 112
Query: 125 VTPVNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR 179
V V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G
Sbjct: 113 VARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGE 172
Query: 180 -VYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLA 238
+ HY+I +G Y++ F +L LV H+S GDGL +L P + + P A
Sbjct: 173 LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN--PWA 230
Query: 239 PPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIM 298
D WEI R + + KLG GQ+G+V+ +K N+ VA+KTLK+ TM+ + FL EA++M
Sbjct: 231 Q-DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVM 288
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--GARECVPGAVVLMYMATQI 356
K ++H LV+L V T+EP YI+TE+M+RG LL++L+ G+R +P L+ M+ QI
Sbjct: 289 KALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPR---LIDMSAQI 344
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTA 416
A GM+Y+E + IHRDL A N LV E K+ADFGLAR++ D YTA GAKFPIKWTA
Sbjct: 345 AEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTA 403
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE + + F+ K+DVW+FG+LL E+ TYG PYPG+ +V LE+
Sbjct: 404 PEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLER 450
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 315 bits (773), Expect = 2e-84
Identities = 166/396 (41%), Positives = 242/396 (61%), Gaps = 19/396 (4%)
Query: 67 EEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVT 126
E++ ++ VA+YDFQA + L L++G++ I+ N W A G G++PSNYVT
Sbjct: 177 EDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDV-HWWRARDKYGNEGYIPSNYVT 235
Query: 127 --PVNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG--- 178
N+L+++ WY ++R+ AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 236 GKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGS 294
Query: 179 ---RVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK--PT 233
R YH + + K Y+ + FG++ E++ +H GL+T+L YP + K PT
Sbjct: 295 SGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPT 354
Query: 234 VFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLE 293
+ + WEI+ +++ +LG G +G V W R VA+K +++ M +DF+E
Sbjct: 355 TAGFSY-EKWEINPSELTFMRELGSGLFGVVRLGKW-RAQYKVAIKAIREGAMCEEDFIE 412
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMA 353
EA +M ++ HP LVQL GVCT++ P YI+TEFM RG LL +LR R+ VL+ M
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ--RQGHFSRDVLLSMC 470
Query: 354 TQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIK 413
+ GM YLE SFIHRDLAARNCLV E +VKV+DFG+AR + DD YT+ +GAKFP+K
Sbjct: 471 QDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVK 530
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
W PE Y+ FS+KSDVW+FG+L+WE+ T G P+
Sbjct: 531 WCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPF 566
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 301 bits (740), Expect = 2e-80
Identities = 158/385 (41%), Positives = 231/385 (60%), Gaps = 16/385 (4%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPV-NSLEK 133
VALYD+ N L L+KG++ I+ + W A G G++PSNYVT +S+E
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNL-PWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
Query: 134 HSWYHGPISRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRY------EGRVYHYRIN 186
+ WY ++R+ AE LL G G F+VR+S S G+ ++S+ +G + HY +
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
Query: 187 EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK--PTVFPLAPPDHWE 244
+ Y+ + F T+ EL+++H GLI++L YP +++K P+ L WE
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS-WE 396
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
ID D+ +LG GQ+G V W RG VA+K +K+ +M+ +F+EEA +M + H
Sbjct: 397 IDPKDLTFLKELGTGQFGVVKYGKW-RGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 455
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
LVQL GVCT++ P +IITE+M+ G LL YLR L+ M + M YLE
Sbjct: 456 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLE 513
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNT 424
S+ F+HRDLAARNCLV + +VKV+DFGL+R + DD YT+ G+KFP++W+ PE L Y+
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
Query: 425 FSTKSDVWAFGILLWEIATYGMSPY 449
FS+KSD+WAFG+L+WEI + G PY
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPY 598
>UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep:
Zgc:153964 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 511
Score = 296 bits (727), Expect = 7e-79
Identities = 161/401 (40%), Positives = 247/401 (61%), Gaps = 15/401 (3%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHT--LTGAV--GWVPSNYVTPV 128
+++AL+DF+A + +L+ K G++ I ++SG+W A+ + G V G+VP NY+
Sbjct: 70 IYMALWDFKARNDQELSFKAGDKFEIT--DRSGDWWTANKKDIFGRVTTGFVPYNYLAR- 126
Query: 129 NSLEKHSWYHGPISR-NAAEYLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRIN 186
+S+E W+ G ++R A +L+S N GSFLVR SES +S+R + H++I
Sbjct: 127 DSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIF 186
Query: 187 EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEID 246
+ D + YV + KF ++ E++ H+ + I LL R KP P D WE+
Sbjct: 187 QTGD-QFYVDALFKFSSIVEVIEHYQ-SHPLSIGDLLSEPCIRIKPENVPPPSTDEWELP 244
Query: 247 RTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKD-DTMALKDFLEEASIMKEMRHPN 305
+ + ++++LG G + DVY WK + VA+K LK+ D + L++F E IMK +RH +
Sbjct: 245 KEEFQLENQLGSGHFADVYSGKWKNHS-KVAIKILKNNDALVLREFQLEVQIMKRLRHKH 303
Query: 306 LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLES 365
L+ L VCT PFYIITE + +G+LL +LR + L+ MA Q+A GM+YLE+
Sbjct: 304 LISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQ-MESLIDMAAQVADGMAYLEA 362
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTF 425
+ IHRDLAARN LVG+ ++ K+ADFGLAR++++ Y + K P KWTAPE + + T+
Sbjct: 363 NNSIHRDLAARNVLVGDGYVCKIADFGLARIIKEPVYLSD-DKKIPYKWTAPEAIGHGTY 421
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKF 466
S+KSDVW+FGILL+EI T+G PYPGV+ +VY ++ K +
Sbjct: 422 SSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDLITKENY 462
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 287 bits (703), Expect = 6e-76
Identities = 150/395 (37%), Positives = 233/395 (58%), Gaps = 18/395 (4%)
Query: 68 EDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTP 127
E + + +ALYD+Q +L L++ E+ ++ ++ W G G+VPS+Y+
Sbjct: 170 EPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGYVPSSYLVE 228
Query: 128 V--NSLEKHSWYHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVY--- 181
N+LE + WY+ ISR+ AE LL +G G+F+VR+S ++ G ++S+ + V
Sbjct: 229 KSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENN 287
Query: 182 ----HYRINEDADG--KVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAP-KRSKPTV 234
HY I E D + YV + F ++ L+++H G GL+T+L YP R K V
Sbjct: 288 PCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV 347
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEE 294
W ID +++ ++G GQ+G V+ W + VA+KT+++ M+ +DF+EE
Sbjct: 348 TAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKD-KVAIKTIREGAMSEEDFIEE 406
Query: 295 ASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMAT 354
A +M ++ HP LVQL GVC + P ++ EFM G L +YLR + + A L+ M
Sbjct: 407 AEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT--QRGLFAAETLLGMCL 464
Query: 355 QIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKW 414
+ GM+YLE IHRDLAARNCLVGEN ++KV+DFG+ R + DD YT+ G KFP+KW
Sbjct: 465 DVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKW 524
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
+PE +++ +S+KSDVW+FG+L+WE+ + G PY
Sbjct: 525 ASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPY 559
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 285 bits (698), Expect = 2e-75
Identities = 156/388 (40%), Positives = 225/388 (57%), Gaps = 16/388 (4%)
Query: 71 PQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTG--AVGWVPSNYVTPV 128
PQLF+ALYDF A +L++++G+ R+ + + G + A L+G + G VP +V
Sbjct: 53 PQLFLALYDFTARCGGELSVRRGD--RLCALEEGGGYIFARRLSGQPSAGLVPITHVAKA 110
Query: 129 N--SLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYR 184
+ +L WY +SR A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWE 244
++ ADG +Y+ F L EL+ ++ + LL P + P D WE
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR------QDVWE 224
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
++ + KLG G +G+V+E W G++ VA+K +K M L D +E +K +RH
Sbjct: 225 RPHSEFALGRKLGEGYFGEVWEGLWL-GSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHE 283
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
L++L VC+ P YI+TE M +GNL +L + +L + A Q+A GMSYLE
Sbjct: 284 RLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGF-ACQVAEGMSYLE 342
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNT 424
+ +HRDLAARN LV + KVADFGLARL++DD Y+ + +K P+KWTAPE Y
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
Query: 425 FSTKSDVWAFGILLWEIATYGMSPYPGV 452
FS KSDVW+FG+LL E+ TYG PY G+
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGM 430
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 284 bits (697), Expect = 3e-75
Identities = 159/396 (40%), Positives = 229/396 (57%), Gaps = 16/396 (4%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKH 134
+A Y+F E L KG+ + I++ K W +A G G +P+NYV ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 135 S------WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINED 188
+ W+HG I+R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 189 ADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRT 248
A K+ + E F L +LV H++ DGL T+L+ P W ++
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMK 193
Query: 249 DIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQ 308
++ + +G G++GDV + RGN VAVK +K+D A + FL EAS+M ++RH NLVQ
Sbjct: 194 ELKLLQTIGKGEFGDVMLGDY-RGN-KVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQ 250
Query: 309 LLGVCTREPP-FYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRS 367
LLGV E YI+TE+M++G+L++YLR+ R + G +L + + + M YLE +
Sbjct: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-SLDVCEAMEYLEGNN 309
Query: 368 FIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFST 427
F+HRDLAARN LV E+++ KV+DFGL + + + T G K P+KWTAPE L FST
Sbjct: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTG-KLPVKWTAPEALREKKFST 365
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
KSDVW+FGILLWEI ++G PYP + L DV +EK
Sbjct: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 510
Score = 283 bits (693), Expect = 9e-75
Identities = 156/408 (38%), Positives = 249/408 (61%), Gaps = 22/408 (5%)
Query: 68 EDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL--TGAV---GWVPS 122
E +L+ AL+ ++A G ++L+ ++GEQ RI + GEW A L GAV G+VP+
Sbjct: 52 EPGSELYKALWSYKARGADELSFQEGEQFRICE--RQGEWWTALKLGRDGAVTGRGFVPN 109
Query: 123 NYVTPVNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGR- 179
+++ ++++ WY G ++R E LL + N G+FLVR SE +S+ R
Sbjct: 110 HFLARRQTVKEQPWYFGTLNRFETEILLLAPENDVGAFLVRHSEKDNIGYVLSVLSGDRS 169
Query: 180 --VYHYRINEDADGKVYVTSESKFGTLAELVHHH---SVAGDGLITQLLYPAPK-RSKPT 233
V H +I+++ + Y+ F +L +LV ++ S+ GD + Q P + + KP
Sbjct: 170 REVKHIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLDGDSFLKQ---PCRRVKPKPK 226
Query: 234 VFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLE 293
+ + WE+ + + ++ +LG G + DVY WK G + VA+K LK+D++ ++F+
Sbjct: 227 DLSHSTVNDWELPKEEFTLEEELGKGFFADVYRGKWK-GMVNVAIKILKNDSINHREFML 285
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMA 353
E I+K++RH +L+ L VCT PFYIITE M +G+LL L+ + + A +L MA
Sbjct: 286 ETQILKKLRHKHLIALFAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDL-NAQMLTEMA 344
Query: 354 TQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIK 413
+Q+A GM+YLE ++ IHRDLAARN LVG N++ KVAD GLAR++++ Y++ A+ P K
Sbjct: 345 SQVADGMAYLEEQNSIHRDLAARNVLVGANYICKVADLGLARIVKESVYSSE-DAQIPYK 403
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
W+APE +++ FS KSDVW+FG+LL+E+ TYG PYP +VY+M+
Sbjct: 404 WSAPEAISHGRFSNKSDVWSFGVLLYEMFTYGGVPYPAFSNIEVYNMI 451
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 281 bits (689), Expect = 3e-74
Identities = 153/385 (39%), Positives = 220/385 (57%), Gaps = 40/385 (10%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTP-VNSLEK 133
+A Y++ N L L+K E+ ++ + W +A G G++PSNY+ +N LEK
Sbjct: 179 IAEYEYAPMTTNDLELRKDEEYTLLEISDPN-WFKAKDKYGKEGYIPSNYIVQALNGLEK 237
Query: 134 HSWYHGPISRNAAEYLLSS-GINGSFLVRESESSPGQRSISL------RYEGRVYHYRIN 186
+ WY I+R+ AE LL + +G FLVR+S G+ ++S+ G HY I
Sbjct: 238 YDWYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRHYNIL 297
Query: 187 EDADGKVYVTSESKFGTLAELV--HHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWE 244
ADG+ Y+ + F + EL+ H H+ AG WE
Sbjct: 298 LTADGQFYLAEKHNFTNIPELINYHQHNAAGS--------------------------WE 331
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
ID + +LG GQ+G V W+ G VA+K +K+ +M+ DF+EEA +M ++ H
Sbjct: 332 IDPRQLTFIRELGNGQFGVVKYGKWQ-GRHDVAIKMVKEGSMSEDDFIEEAKVMMKLCHG 390
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
NLVQL GVCT++ P YI+TE+++ G LL YL+ G P ++ L+ M ++ GM YLE
Sbjct: 391 NLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGLLN--PTSIALLEMCKDVSEGMKYLE 448
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNT 424
+ FIHRDLAARNCLV N +KV DFGL+R + DD YT+ G+KFP++W+ PE L Y
Sbjct: 449 ANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCK 508
Query: 425 FSTKSDVWAFGILLWEIATYGMSPY 449
FS+KSD+WAFG+L+WEI T G PY
Sbjct: 509 FSSKSDIWAFGVLMWEIYTQGRMPY 533
>UniRef50_A2RQD3 Cluster: Bcr-abl1 e13a3 chimeric protein; n=21;
Eumetazoa|Rep: Bcr-abl1 e13a3 chimeric protein - Homo
sapiens (Human)
Length = 235
Score = 280 bits (687), Expect = 5e-74
Identities = 126/165 (76%), Positives = 144/165 (87%), Gaps = 2/165 (1%)
Query: 91 KKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLL 150
K+GE++R++ YN +GEWCEA T G GWVPSNY+TP NSLEKHSWYHGP+SRNAAEYLL
Sbjct: 72 KEGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPANSLEKHSWYHGPVSRNAAEYLL 130
Query: 151 SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHH 210
SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN +DGK+YV+SES+F TLAELVHH
Sbjct: 131 SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHH 190
Query: 211 HSVAGDGLITQLLYPAPKRSKPTVFPLAPP-DHWEIDRTDIVMKH 254
HS DGLIT L YPAPKR+KPTV+ ++P D WE++RTDI MKH
Sbjct: 191 HSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKH 235
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 278 bits (681), Expect = 3e-73
Identities = 160/405 (39%), Positives = 225/405 (55%), Gaps = 24/405 (5%)
Query: 76 ALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKHS 135
A YDF + L KKG+ + I + + W TG G +P+NYV + S K +
Sbjct: 26 AAYDFNGASKEDLPFKKGDILTIENPTEDPNWWLVRDKTGRTGMIPANYVELIGSDTKKT 85
Query: 136 ---------------WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 180
W+HG ISR AE LL +G FLVRES PG ++ + ++ +V
Sbjct: 86 GTLPRDASGQLIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQV 145
Query: 181 YHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRS-KPTVFPLAP 239
HYR+ + +GK+ + E F +L ELV H+ DGL T+L P K+ +
Sbjct: 146 DHYRM-QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTRLRKPVVKQGGREFKIDARK 204
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKD-DTMALKDFLEEASIM 298
+WEI +IV ++G GQ+GDV+E + RG VA+KTLKD A+ FL EA M
Sbjct: 205 FVNWEISPREIVKSAQIGSGQFGDVFEGLY-RGQ-KVAIKTLKDVQGDAIDQFLLEADTM 262
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+RH NLVQL+GVCT+ P I++EFM +G LL+YLR+ R + A L + I +
Sbjct: 263 TRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGF-CRDICA 321
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPE 418
M YLE + F+HRDLAARN L+ ++ + KVADFGLA+ D K PIKWTAPE
Sbjct: 322 AMEYLEEQKFVHRDLAARNILLSDDGVAKVADFGLAK---DSQLGVTDIGKLPIKWTAPE 378
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ ++KSDVW+FG++LWEI +G +PYP + +V + K
Sbjct: 379 AIRLKVSTSKSDVWSFGVVLWEIFAFGRAPYPRMGQKEVVDAVVK 423
>UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF5507, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1116
Score = 277 bits (680), Expect = 3e-73
Identities = 143/324 (44%), Positives = 200/324 (61%), Gaps = 9/324 (2%)
Query: 136 WYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
WY+G I+R AE LL + N GSFLVR SES + +IS R EG+V+H+RI + G
Sbjct: 250 WYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGAY 309
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK--PTVF----PLAPPDHWEIDR 247
+V+ F TL EL+ ++ L L P ++ P++ L + WE R
Sbjct: 310 FVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQRELFDMEPWERPR 369
Query: 248 TDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLV 307
+ + KLG G +G+V+EA W N VA+KTLK + +F++E +K + HP L+
Sbjct: 370 EEFRLLRKLGEGHFGEVWEALWSTENRRVAIKTLKQEDTKQDEFVKEVQALKSLHHPKLI 429
Query: 308 QLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRS 367
QLL +C+R P YI+TE M++G+L YL A A V + L+YM +QIA GM+YLE R+
Sbjct: 430 QLLAMCSRGEPVYIVTELMTKGSLKAYL-ASAEGQVLTSAHLIYMGSQIAEGMAYLEDRN 488
Query: 368 FIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFST 427
+HRDLAARN LVGE+ + KVADFGLAR+++D YTA K P++WTAPE + FS
Sbjct: 489 IVHRDLAARNILVGEDLVCKVADFGLARIIKDSVYTASRNTKIPVRWTAPEAAIHQRFSV 548
Query: 428 KSDVWAFGILLWEIATYGMSPYPG 451
KSDVW+FG+LL+E+ + G PY G
Sbjct: 549 KSDVWSFGVLLYEMMSRGKMPYEG 572
Score = 233 bits (570), Expect = 7e-60
Identities = 128/299 (42%), Positives = 177/299 (59%), Gaps = 7/299 (2%)
Query: 156 GSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAG 215
G+FL+R SE +S+R +V HY++ + + YV +F +LAELV ++
Sbjct: 736 GAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTS 795
Query: 216 DGLITQLLYPAPKR--SKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN 273
L P + S P + P P WE+ + + ++ +LG G + VY WK
Sbjct: 796 LNNAGPLGNPCKRNTLSTPALLPF-PTIGWELPKKEFELEEELGSGCFARVYRGRWKN-L 853
Query: 274 ITVAVKTLKDDT-MALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLL 332
I VAVK LK D+ + DF E I+K +RH +L+ L VCT P++IITE M +G+LL
Sbjct: 854 IRVAVKILKSDSELNHGDFQTEVQILKNLRHRHLLSLFAVCTESRPYWIITELMEKGSLL 913
Query: 333 EYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
+LR+ + A L+ M TQ+A GMSYLE + IHRDLAARN LVGE++ KV DFG
Sbjct: 914 IFLRSPEGQNQDVAS-LIDMGTQVADGMSYLEEQKSIHRDLAARNVLVGEDYTCKVGDFG 972
Query: 393 LARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
LAR++++ Y K P KWTAPE +++ FS KSDVW+FGILL+EI TYG PYPG
Sbjct: 973 LARVIKEPFYITE-DKKIPYKWTAPEAISHGKFSNKSDVWSFGILLYEITTYGGVPYPG 1030
Score = 95.5 bits (227), Expect = 3e-18
Identities = 65/219 (29%), Positives = 108/219 (49%), Gaps = 13/219 (5%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL--TGAV---GWVPSNYVTP 127
++ AL+ FQ+ L+ ++G+ R++S + +W + +G V G VP NY+ P
Sbjct: 3 IYRALWAFQSQQGEHLSFREGDLFRVLS--RRDDWWSVRRIDASGRVLDSGLVPGNYLAP 60
Query: 128 VNSLEKHSWYHGPISR-NAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 185
S + W+ G ++R A +LL+ G+FL+R SE +S+R +V HY++
Sbjct: 61 AESGQTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKV 120
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKR--SKPTVFPLAPPDHW 243
+ + YV +F +LAELV ++ L P + S P + P P W
Sbjct: 121 LQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLPF-PTIGW 179
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLK 282
E+ + + ++ +LG G + VY WK I VAVK LK
Sbjct: 180 ELPKKEFELEEELGSGCFARVYRGRWK-NLIRVAVKILK 217
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 276 bits (677), Expect = 8e-73
Identities = 144/339 (42%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDAD 190
L+ W+HG ISR AE LL+ NG FLVRES++ PG ++ + Y+GRV +YR+ +
Sbjct: 104 LKTMPWFHGRISREDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNEK 163
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDH----WEID 246
G V V + F L +LV H+ DGL T+L P K + +F + D W I
Sbjct: 164 GLVTVDDDEYFDNLIKLVEHYQKEADGLCTRLKAPVDKEGQ-HLFVVDVNDFKEKGWAIP 222
Query: 247 RTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKD---DTMALKDFLEEASIMKEMRH 303
+ ++ K +G G++G+V+ ++ VA+K++KD D A FL EAS+M +RH
Sbjct: 223 KASLLKKSLIGKGEFGEVWLGDYE--GKKVAMKSMKDHLKDEKAKTQFLAEASVMTTLRH 280
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
PNLV L+G+ + P Y+ITEFM++G+L++YLR+ R + + + A + GM YL
Sbjct: 281 PNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDF-ARDVVKGMVYL 339
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYN 423
ES++F+HRDLAARN L+ E+++ KV+DFGLA + + GAK P+KWTAPE L N
Sbjct: 340 ESQNFVHRDLAARNVLIAEDNVAKVSDFGLA---KSSSNVKQEGAKLPVKWTAPEALREN 396
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
FS K+DVW+FG+LLWEI +YG PYP V + DV + +E
Sbjct: 397 KFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANHVE 435
Score = 37.5 bits (83), Expect = 0.76
Identities = 16/51 (31%), Positives = 27/51 (52%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYV 125
+ Y+F + L KKG+++ I++ +K W +A G G +P NYV
Sbjct: 12 IGKYNFPGSSPHDLPFKKGDRLVIVAPSKDPNWYKARREDGLEGMIPFNYV 62
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 276 bits (676), Expect = 1e-72
Identities = 155/401 (38%), Positives = 225/401 (56%), Gaps = 20/401 (4%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLT-GAVGWVPSNYVTPVNSLEK 133
VA YDF+ E L KKG+ + I+ + W A ++ G G +P NYV +L
Sbjct: 28 VARYDFKGNSEKDLPFKKGDIIEILQSTRDPNWYNAKKVSDGRTGLIPINYVQQRRALHL 87
Query: 134 HS--WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRS---ISLRYEGRVYHYRINED 188
H W+ G I+R AE LL+ G FLVRES + PG + +S + +V HYR+
Sbjct: 88 HEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVIST 147
Query: 189 ADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK---PTVFPLA-PPDHWE 244
+D +V V E+ F TL EL+ H+ DGL T L P K+++ +F + + W
Sbjct: 148 SDNQVTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTEILQSAIFKESFQKEGWA 207
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHP 304
+ D+ K +G G++G+VY+ W + TVA+K L+DD+ + L EAS+M ++H
Sbjct: 208 VPIEDVEFKELIGKGEFGNVYKGVWAKK--TVAIKKLRDDSKTAQSLLAEASVMTTLQHK 265
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
NLV L+ + + I+TE+ +G L+EYLR R + + A + +GM YLE
Sbjct: 266 NLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGF-AIDVCNGMRYLE 324
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNT 424
++ IHRDLAARN L+ + KV+DFGLA+ D A KFP+KWTAPE +
Sbjct: 325 EKNIIHRDLAARNVLLSDELCAKVSDFGLAK----DVEQELASGKFPVKWTAPEAIELKI 380
Query: 425 FSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVK 465
FSTKSDVW+FGILLWEI ++G +PYP L + +L K+K
Sbjct: 381 FSTKSDVWSFGILLWEIFSFGRNPYPREPLDE---LLTKIK 418
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 270 bits (662), Expect = 5e-71
Identities = 142/357 (39%), Positives = 212/357 (59%), Gaps = 15/357 (4%)
Query: 111 HTLTGAVGWV--PSNYVTPVNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSP 167
HT T + W S+ +L+ + W+ G ISR+ +E LL G G+F+VR S S
Sbjct: 270 HT-TSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQV 327
Query: 168 GQRSISL------RYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQ 221
G ++SL +G V HY ++ +A+ K+Y+ F ++ +L+H+H G+IT+
Sbjct: 328 GMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITR 387
Query: 222 LLYPAPKRSKPTVFPLAPPDH-WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKT 280
L +P ++ ++ + WE+ R +I + +LG GQ+G V WK G VAVK
Sbjct: 388 LRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWK-GQYDVAVKM 446
Query: 281 LKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGAR 340
+K+ +M+ +F +EA M ++ HP LV+ GVC++E P YI+TE++S G LL YLR+ +
Sbjct: 447 IKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGK 506
Query: 341 ECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD 400
P L+ M + GM++LES FIHRDLAARNCLV + VKV+DFG+ R + DD
Sbjct: 507 GLEPSQ--LLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDD 564
Query: 401 TYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
Y + G KFP+KW+APE Y +S+KSDVWAFGIL+WE+ + G PY D + V
Sbjct: 565 QYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQV 621
>UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11;
Mammalia|Rep: Tyrosine-protein kinase 6 - Homo sapiens
(Human)
Length = 451
Score = 268 bits (656), Expect = 3e-70
Identities = 153/385 (39%), Positives = 222/385 (57%), Gaps = 12/385 (3%)
Query: 74 FVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTG---AVGWVPSNYVTPVNS 130
+V L+DF++ + +L+ + G+ + + W G A G+VP NY+ +
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 131 LEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINED 188
+E W+ G ISR+ A L + N G+FL+R SE +S+R V HY+I
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
Query: 189 ADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRT 248
A G++++ F +L ELV++H L L AP R K PL D WE R
Sbjct: 133 AGGRLHLNEAVSFLSLPELVNYHRA--QSLSHGLRLAAPCR-KHEPEPLPHWDDWERPRE 189
Query: 249 DIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLE-EASIMKEMRHPNLV 307
+ + KLG G +G+V+E WK + VA+K + D + + L+ E MK++RH +++
Sbjct: 190 EFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 248
Query: 308 QLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRS 367
L V + P YIITE M++G+LLE LR + +P + L+ +A Q+A GM YLES++
Sbjct: 249 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSE-LLDIAWQVAEGMCYLESQN 307
Query: 368 FIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFST 427
+IHRDLAARN LVGEN L KV DFGLARL+++D Y +H P KWTAPE L+ +ST
Sbjct: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
Query: 428 KSDVWAFGILLWEIATYGMSPYPGV 452
KSDVW+FGILL E+ + G PYPG+
Sbjct: 367 KSDVWSFGILLHEMFSRGQVPYPGM 391
>UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1;
Eptatretus burgeri|Rep: TEC family protein tyrosine
kinase - Eptatretus burgeri (Inshore hagfish)
Length = 636
Score = 267 bits (654), Expect = 5e-70
Identities = 152/388 (39%), Positives = 221/388 (56%), Gaps = 15/388 (3%)
Query: 72 QLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVN-- 129
Q VA +DF L L KG I+ +K+ W A G G +PS YV P+
Sbjct: 196 QQVVAKFDFPGIEAQDLPLVKGCTYVILD-DKNPHWWRAQDEEGREGLIPSTYVYPLTRF 254
Query: 130 SLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYE----GRVYHYR 184
LE++ W+ I+R AE LL +G GSFLVRES S G+ ++S+ Y V HY
Sbjct: 255 DLEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRES-SQVGKLTVSV-YSCIPCEVVKHYH 312
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPA-PKRSKPTVFPLAPPDHW 243
+ + G+ Y+ + F T+++L+H+H GL+T+L +P P P+ L+ W
Sbjct: 313 VKQLPTGEWYLAEKHTFSTISDLIHYHQHNAAGLVTRLRHPVRPGEELPSTAGLSY-GKW 371
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRH 303
E+D ++ +LG G G V W RG +A++ L + +A DF E +M ++ H
Sbjct: 372 ELDALELTSLRELGRGALGVVQLGMW-RGVRHIAIRMLHEGVLAEDDFFHEVKLMMQLSH 430
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
PNLVQL GV TR P I+ E+++ G L +L+A R G+ L+ + + M YL
Sbjct: 431 PNLVQLYGVVTRYRPLRIVMEYLALGCLRTFLQA--RPGKLGSAWLLEACSDVCKAMVYL 488
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYN 423
ES SF+HRDLAAR+CLVGE+ +KV+DFG+AR + DD YT GA+FP+KW+ PE
Sbjct: 489 ESNSFLHRDLAARHCLVGEDFSIKVSDFGMARYVLDDQYTCSQGARFPVKWSPPEVFDRG 548
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPG 451
FS+KSDVW+FG+++WE+ + G PY G
Sbjct: 549 RFSSKSDVWSFGVVMWEVFSEGTLPYDG 576
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 260 bits (636), Expect = 7e-68
Identities = 139/331 (41%), Positives = 203/331 (61%), Gaps = 14/331 (4%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYV 195
W+HG I+R+ AE+LL +G FLVRES + PG ++ + ++ +V HYR+ + K+ +
Sbjct: 479 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKY-LENKLTI 537
Query: 196 TSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDH----WEIDRTDIV 251
E F L +LV H+ DGL TQL+ PK K F + D W I ++
Sbjct: 538 DDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQE-FCINSKDFVDKGWVIPEAELQ 596
Query: 252 MKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLG 311
++ +G G++GDV + N VAVK LKD+ A++ FL EAS+M + H NLV+ +G
Sbjct: 597 LRESIGKGEFGDVMLGILR--NEKVAVKMLKDEG-AVQKFLAEASVMTTLEHDNLVKFIG 653
Query: 312 VCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHR 371
+ Y++TE+MS+G+L++YLR+ R+ + +++ A ASGM YLE++ +HR
Sbjct: 654 LVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIF-AYDTASGMEYLEAKKVVHR 712
Query: 372 DLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDV 431
DLAARN L+ E+ + KV+DFGLAR ++ Y G K PIKWTAPE L FS KSD+
Sbjct: 713 DLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDM 768
Query: 432 WAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
W+FGILLWEI ++G PYP + LADV +E
Sbjct: 769 WSFGILLWEIYSFGRVPYPRIPLADVVKHVE 799
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 257 bits (629), Expect = 5e-67
Identities = 138/322 (42%), Positives = 192/322 (59%), Gaps = 10/322 (3%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYV 195
W+HG I R AE LL +G FLVRES + PG ++ + + +V HYRI A+ K+ +
Sbjct: 378 WFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKY-AENKLTI 436
Query: 196 TSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHK 255
+ F L +LV H+++ DGL T+L+ PK + WEI D+ +K
Sbjct: 437 DDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEE--FCVKDFQDNGWEIKMEDLQLKEN 494
Query: 256 LGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTR 315
+G G++GDV K VAVK LKD A FL EA +M + H NLV+ +G+
Sbjct: 495 IGKGEFGDVMLGILKGEK--VAVKVLKDAGRASNKFLAEAGVMTTLEHENLVKFIGLVFH 552
Query: 316 EPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAA 375
+ Y++TE+MS+G+L++YLR+ R+ + + + A SGM YLE + IHRDLAA
Sbjct: 553 DKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINF-AFDTCSGMEYLEMKKVIHRDLAA 611
Query: 376 RNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFG 435
RN L+ E + KV+DFGLAR D+ YTA +K PIKWTAPE L FS K+D+W+FG
Sbjct: 612 RNVLISEECVAKVSDFGLAR---DERYTADI-SKLPIKWTAPEALKEGKFSNKTDMWSFG 667
Query: 436 ILLWEIATYGMSPYPGVDLADV 457
ILLWEI ++G PYP + LADV
Sbjct: 668 ILLWEIYSFGRVPYPRIPLADV 689
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 256 bits (628), Expect = 7e-67
Identities = 142/323 (43%), Positives = 195/323 (60%), Gaps = 15/323 (4%)
Query: 136 WYHGPISRNAAEY-LLSSGIN-GSFLVRESESSPGQRSISLRYEG-----RVYHYRI-NE 187
W G SR AE L++ GIN G F+VR+ + PG +S+R V HYRI
Sbjct: 7 WDFGMCSRQDAEKKLMAIGINKGQFIVRDRD--PGTFELSVRDNNPQKGDHVKHYRIWKM 64
Query: 188 DADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDR 247
D ++ S F T++ELV H+ + DGL +L PK + P L D WE R
Sbjct: 65 DGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKEN-PNTIGLGK-DKWETPR 122
Query: 248 TDI-VMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNL 306
+ M +LG G++G+V++ W GN VAVKTLK+ TM+ FL EA++MK++RH +
Sbjct: 123 KSLGQMNRRLGEGKFGEVWQGVWN-GNTPVAVKTLKERTMSPAAFLAEANVMKKLRHEGI 181
Query: 307 VQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESR 366
VQL VC+ + P YI+TE MS G+L YL++ + L+ M IASGM YL S+
Sbjct: 182 VQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTK-MTTLIDMGAHIASGMDYLGSK 240
Query: 367 SFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFS 426
+ +HRDLAARN LVG+ ++VK+ADFG A+LM D Y GAK P+KWTAPE + + F+
Sbjct: 241 NVVHRDLAARNVLVGKGNVVKIADFGRAQLMEKDVYVGEEGAKLPLKWTAPEAVLHGRFT 300
Query: 427 TKSDVWAFGILLWEIATYGMSPY 449
KSDVW+FGIL+ E+ T+G PY
Sbjct: 301 IKSDVWSFGILMTEMVTFGGYPY 323
>UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC
2.7.10.2).; n=1; Xenopus tropicalis|Rep:
Tyrosine-protein kinase Tec (EC 2.7.10.2). - Xenopus
tropicalis
Length = 647
Score = 256 bits (626), Expect = 1e-66
Identities = 133/317 (41%), Positives = 190/317 (59%), Gaps = 14/317 (4%)
Query: 156 GSFLVRESESSPGQRSISL--RYEGR----VYHYRINEDADGKVYVTSESK-FGTLAELV 208
G F+VR S S G ++SL +Y G + HY I E K Y +E F T+ E++
Sbjct: 311 GGFIVRNS-SQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVFNTIPEMI 369
Query: 209 HHHSVAGDGLITQLLYPAPKRSK--PTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYE 266
+H GL+T+L YP ++K PT + D WEI+ +++ +LG G +G V
Sbjct: 370 EYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSY-DKWEINPSELTFMKELGSGLFGVVRL 428
Query: 267 AAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFM 326
W R VA+K +++ M+ +DF+EEA +M ++ H LVQL GVCT++ P YI+TEFM
Sbjct: 429 GKW-RAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVCTQQRPIYIVTEFM 487
Query: 327 SRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLV 386
G LL YLR + P +L+ M + MSYLE +FIHRDLAARNCLV + +V
Sbjct: 488 EHGCLLNYLRQRHGQFSPD--ILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAGVV 545
Query: 387 KVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGM 446
KV+DFG+ R + DD YT+ GAKFP+KW+ PE Y+ FS+KSDVW+FG+L+WE+ T G
Sbjct: 546 KVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGK 605
Query: 447 SPYPGVDLADVYHMLEK 463
P+ +V M+ +
Sbjct: 606 MPFESYSNVEVVEMVTR 622
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 249 bits (609), Expect = 1e-64
Identities = 142/399 (35%), Positives = 219/399 (54%), Gaps = 18/399 (4%)
Query: 75 VALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKH 134
VA +++ G + + + K + ++ + W + L G G+VPS + +
Sbjct: 191 VAQCNYEPSGNSAIRVVKSNKYHVLQ-EEDFAWWKVRDLEGNEGFVPSTCLAGQKK-NQE 248
Query: 135 SWYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRS------ISLRYEGRVYHYRIN 186
WY ISR +E LL S I+G F V ++ S S +G V HY ++
Sbjct: 249 IWYVAGISRAQSEQLLHQSPKISG-FTVALAQMSRLYTSKMKSPFYGENKKGTVKHYHVH 307
Query: 187 EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKR-SKPTVFPLAPPDHWEI 245
+ + K Y+T F T+ +L+++H G++ +L + + +K WE+
Sbjct: 308 KTPENKYYLTENHCFETIPKLINYHQHNSAGMVPRLRHVVSTQINKVPATASLGNGIWEL 367
Query: 246 DRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPN 305
R +IV +LG GQ+G V+ WK G VAVK +K+ ++ +F+EEA M ++ HP
Sbjct: 368 KREEIVPLRELGSGQFGAVHLGKWK-GLYDVAVKMIKEGVVSEDEFVEEAQTMMKLNHPK 426
Query: 306 LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLES 365
LV+L GVC++ P Y++ E+M G+LL YL+ +E P + L+ + + M++LES
Sbjct: 427 LVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQP--LQLLEICYDVCDAMAFLES 484
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTF 425
IHRDLAARNCLV N VK++DFG+ + + DD Y + G KFP+KW+APE Y F
Sbjct: 485 CQLIHRDLAARNCLVDSNLTVKLSDFGMTKYVLDDLYVSSLGTKFPVKWSAPEVFHYTKF 544
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKV 464
S+KSDVWAFGIL+WE+ T G PY +L D ++EKV
Sbjct: 545 SSKSDVWAFGILMWEVFTLGKQPY---ELYDNMQVIEKV 580
>UniRef50_Q4RNL0 Cluster: Chromosome 21 SCAF15012, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 21
SCAF15012, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 509
Score = 243 bits (595), Expect = 7e-63
Identities = 147/348 (42%), Positives = 207/348 (59%), Gaps = 17/348 (4%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL-TGAVGWVPSNYVTPVNSL 131
LF+ALYD+ A E+ L+ +KGE+ I++ N G+W EA +L TG G++PSNYV PV+S+
Sbjct: 5 LFIALYDYDARTEDDLSFRKGEKFHIIN-NTEGDWWEARSLDTGNSGYIPSNYVAPVDSI 63
Query: 132 EKHSWYHGPISRNAAE-YLLSSGIN-GSFLVRESESSPGQRSIS-----LRYEGRVYHYR 184
+ WY G + R AE LL+ G G+FL+RESE++ G+ S + L G Y
Sbjct: 64 QAEEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYVGYT 123
Query: 185 ---INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLA--P 239
++ G ++ + V H+ + + + KR P + L+
Sbjct: 124 SVPLHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGGYYITTSCKRGMPKLADLSVKT 183
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMK 299
D WEI R + + KLG GQ+G+V+ W G VAVKTLK TM+ + FLEEA IMK
Sbjct: 184 KDMWEIPRESLQLIKKLGNGQFGEVWMGMWN-GTTKVAVKTLKPGTMSPEAFLEEAQIMK 242
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASG 359
+RH LVQL V + EP YIITEFMS+G+LL++L+ G + + L+ MA QIASG
Sbjct: 243 RLRHDKLVQLYAVVSEEP-IYIITEFMSQGSLLDFLKDGEGQNLK-LPQLVDMAAQIASG 300
Query: 360 MSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAG 407
M+Y+E ++IHRDL A N LVG+N + K+ADFGLARL+ D+ YTA G
Sbjct: 301 MAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQG 348
Score = 78.2 bits (184), Expect = 4e-13
Identities = 34/73 (46%), Positives = 48/73 (65%)
Query: 391 FGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
+ ++ +M + +GAKFPIKWTAPE Y F+ KSDVW+FGILL E+ T G PYP
Sbjct: 381 YTISVIMNRHSVAMVSGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELITKGRVPYP 440
Query: 451 GVDLADVYHMLEK 463
G++ +V +E+
Sbjct: 441 GMNNREVLEQVER 453
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 240 bits (588), Expect = 5e-62
Identities = 134/335 (40%), Positives = 195/335 (58%), Gaps = 16/335 (4%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDAD 190
L + WYHG I R A+ LL G FLVRES PG+ +S+ +G+ H+ I + D
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFII-QYVD 511
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDI 250
+Y + F + +L+ HH +IT+ K + P+ W + D+
Sbjct: 512 N-MYRFEGTGFSNIPQLIDHHYTTKQ-VITK------KSGVVLLNPIPKDKKWILSHEDV 563
Query: 251 VMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDT-MALK-DFLEEASIMKEMRHPNLVQ 308
++ LG G +G+VY+ K +VAVKT K+D LK FL+EA I+K+ HPN+V+
Sbjct: 564 ILGELLGKGNFGEVYKGTLK-DKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVK 622
Query: 309 LLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSF 368
L+GVCT+ P YII E +S G+ L +LR E L+ + A+GM YLES++
Sbjct: 623 LIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELK--LKQLVKFSLDAAAGMLYLESKNC 680
Query: 369 IHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTK 428
IHRDLAARNCLVGEN+++K++DFG++R Y++ + PIKWTAPE L Y +S++
Sbjct: 681 IHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSE 740
Query: 429 SDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
SDVW+FGILLWE + G+ PYPG+ +E+
Sbjct: 741 SDVWSFGILLWETFSLGVCPYPGMTNQQAREQVER 775
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 238 bits (582), Expect = 3e-61
Identities = 134/339 (39%), Positives = 200/339 (58%), Gaps = 24/339 (7%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDAD 190
+E+ WYHG ISR A LL G FLVR S +++++ EG + H+ I + +
Sbjct: 512 VEEEPWYHGEISRQEATGLLKK--MGDFLVRYSADKE-HYTLTVKMEG-IKHFIIQHNEE 567
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVF-PLAPPD--HWEIDR 247
G + + ++ L+ HH + P ++S+ + P+ PD + I
Sbjct: 568 G--FRFEGDPYPSIPMLIDHHF--------KNRLPVTRKSQAILRQPVKKPDLREYNISH 617
Query: 248 TDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKD-FLEEASIMKEMRHPNL 306
+I++ K+G G +GDV++ K N+ VAVK+ + + K FL+EA I+K+ RHPN+
Sbjct: 618 DNILIGEKIGKGNFGDVFKGYLKTHNMEVAVKSCRSEDFPDKQKFLQEAEILKQYRHPNI 677
Query: 307 VQLLGVCTREPPFYIITEFMSRGNLLEYLRA--GARECVPGAVVLMYMATQIASGMSYLE 364
V+L+GVC + P YII E M+ GN L +LR G R V L M + A+GM +LE
Sbjct: 678 VELIGVCAEKEPLYIIMELMAGGNFLSFLRGPEGKRLKVNN---LTEMCVEAAAGMVFLE 734
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEGLAYN 423
R+ IHRDLAARNCLVG+N+++K++DFG++R D YT +G K PIKWT+PE L Y
Sbjct: 735 QRNCIHRDLAARNCLVGDNNVLKISDFGMSREEDDGIYTVSSGLKQIPIKWTSPEALNYG 794
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
++T+SDVW++GILLWE TYG PYPG++ + +E
Sbjct: 795 RYTTQSDVWSYGILLWETYTYGSGPYPGMNNRETRERIE 833
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 237 bits (581), Expect = 3e-61
Identities = 134/347 (38%), Positives = 197/347 (56%), Gaps = 23/347 (6%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYV 195
W+H ISR E LL +G+FLVRES + PG ++ + + G+V HYRI + + G++
Sbjct: 151 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTC 210
Query: 196 TSESKFGTLAELVHHHSVAGDGLITQLLYPAP------KRSKPTVFPLAPPDHWEIDRT- 248
E F L +LV H+ DGL +L+ P + + F + E DRT
Sbjct: 211 DKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLE-DRTS 269
Query: 249 ------------DIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEAS 296
DI + +G G++GDV +K + + V + M L L+EA
Sbjct: 270 VFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGM-LDSLLDEAK 328
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
M + HPNLV L+GV + Y+ITE+M+ GNL++ LR+ R + ++M+ A I
Sbjct: 329 FMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMF-AMDI 387
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTA 416
GM YLES+ +HRDLAARN L+ ++ + KV+DFGLA+ ++ + +G KFPIKWTA
Sbjct: 388 CQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASG-KFPIKWTA 446
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE L ++ F+TKSDVW+FGILLWEI ++G PYP + + DV +EK
Sbjct: 447 PEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEK 493
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 229 bits (561), Expect = 9e-59
Identities = 134/384 (34%), Positives = 209/384 (54%), Gaps = 17/384 (4%)
Query: 87 QLTLKKGEQVRIMSYNKSGEWCEA-HTLTGAVGWVPSNYVTPVNSLEKHS------WYHG 139
+L +KG+ V I+ ++ W H +G G + + + +L W+HG
Sbjct: 66 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 125
Query: 140 PISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYVTSES 199
IS A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 126 KISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDEAV 184
Query: 200 KFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGG 259
F L ++V H+S + T+L+ P K + W ++ + + ++G G
Sbjct: 185 FFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEG 244
Query: 260 QYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPF 319
++G V + + VAVK +K D A + FL+E ++M +M+H NLV+LLGV +
Sbjct: 245 EFGAVLQGEYLGQK--VAVKNIKCDVTA-QAFLDETAVMTKMQHENLVRLLGVILHQG-L 300
Query: 320 YIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCL 379
YI+ E +S+GNL+ +LR R V A +L + + +A GM YLES+ +HRDLAARN L
Sbjct: 301 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQF-SLHVAEGMEYLESKKLVHRDLAARNIL 359
Query: 380 VGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLW 439
V E+ + KV+DFGLA+ R ++ + P+KWTAPE L + F++KSDVW+FG+LLW
Sbjct: 360 VSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLW 415
Query: 440 EIATYGMSPYPGVDLADVYHMLEK 463
E+ +YG +PYP + L +V +EK
Sbjct: 416 EVFSYGRAPYPKMSLKEVSEAVEK 439
>UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular
organisms|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 225 bits (549), Expect = 3e-57
Identities = 134/337 (39%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 125 VTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 184
V P +E+ W++ + R AE + G +L+R S S + +++ + G+ H+
Sbjct: 515 VPPETRVEEERWFYPNMERKEAEEKCKN--TGDYLIRYS-SKQNRYVLTVCWAGQGKHFV 571
Query: 185 INE--DADGKVYVTSESK-FGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPD 241
I E D K ES+ F ++ EL+ H V +T+ S+P L D
Sbjct: 572 IQEAPDEQTKTKYRFESRSFPSVRELLDFH-VNSQTPVTKA--SGAILSRPI---LREDD 625
Query: 242 HWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKD-DTMALKDFLEEASIMKE 300
W + DI M KLG G +GDV+EAA K G VAVKT + D + FL+EA I+K+
Sbjct: 626 KWALKHEDIKMGRKLGKGAFGDVWEAALK-GQGKVAVKTCRSTDVPDREKFLQEAEILKQ 684
Query: 301 MRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGM 360
HPN+V+L+GV P I+ E M G+LL+YLR A + G L++M+ GM
Sbjct: 685 YDHPNIVKLIGVSWDTEPVLIVMELMPGGSLLDYLRKKAAQMTKGK--LLHMSIDACGGM 742
Query: 361 SYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEG 419
YLES++ IHRDLAARNCLVGEN +VK++DFG++R YT +G + PIKWTAPE
Sbjct: 743 EYLESKNCIHRDLAARNCLVGENDIVKISDFGMSREEEGGMYTVQSGTRQIPIKWTAPEA 802
Query: 420 LAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLAD 456
L Y +++ SDVW+FG+LL+E+ + G +PYPG+ A+
Sbjct: 803 LNYGRYTSASDVWSFGVLLYEVFSGGSTPYPGMSNAE 839
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 222 bits (542), Expect = 2e-56
Identities = 103/195 (52%), Positives = 140/195 (71%), Gaps = 2/195 (1%)
Query: 269 WKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSR 328
WK NI VAVK L++ TM+ + FL+EA+IMK+ RH LV L GVC+ P YI+ E+MS+
Sbjct: 224 WKN-NIEVAVKMLREGTMSTQAFLQEAAIMKKFRHKRLVTLFGVCSEHEPIYIVQEYMSK 282
Query: 329 GNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKV 388
G+LL++LR + + L+Y+A Q+ASGM YLES+ IHRDLAARN L+GEN++ K+
Sbjct: 283 GSLLDFLRKDEGKELEFED-LVYIAFQVASGMEYLESKQLIHRDLAARNVLIGENNIAKI 341
Query: 389 ADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSP 448
DFGLAR++ D+ Y G++FP+KWTAPE + Y FS KSDVW++GI L E+ TYG P
Sbjct: 342 CDFGLARVIEDNEYCPKQGSRFPVKWTAPEAIVYGKFSIKSDVWSYGIFLMELFTYGQVP 401
Query: 449 YPGVDLADVYHMLEK 463
YPG+ +V M+EK
Sbjct: 402 YPGMHGREVIDMVEK 416
Score = 87.4 bits (207), Expect = 7e-16
Identities = 49/150 (32%), Positives = 86/150 (57%), Gaps = 9/150 (6%)
Query: 72 QLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEA-HTLTGAVGWVPSNYVTPVNS 130
++ VALY+++A + ++ KKG+++ ++ + G+W H +T G++P N+V S
Sbjct: 71 RVVVALYNYEARDSSDVSFKKGDRMEVID-DSEGDWLNVIHLITKVQGYIPGNFVAAELS 129
Query: 131 LEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHY 183
+E W+ +SR AE LL + N G+FLVR SE +P S+S++ E V HY
Sbjct: 130 VESEDWFFENVSRKEAEKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEEIREYHVKHY 189
Query: 184 RINEDADGKVYVTSESKFGTLAELVHHHSV 213
+I +G Y+++ F TL ELV+ +++
Sbjct: 190 KIKPLDNGGFYISTNKTFLTLVELVNAYTM 219
>UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine
kinase; n=3; Strongylocentrotus purpuratus|Rep: 220 kDa
ABL-related protein tyrosine kinase - Strongylocentrotus
purpuratus (Purple sea urchin)
Length = 200
Score = 219 bits (535), Expect = 1e-55
Identities = 104/140 (74%), Positives = 116/140 (82%), Gaps = 1/140 (0%)
Query: 324 EFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGEN 383
EFM GNLLEYLR +P AV L+YMATQ+A GMSYLE SFIHRDLAARNCL+GE+
Sbjct: 1 EFMPYGNLLEYLRDNDETSLP-AVTLLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEH 59
Query: 384 HLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIAT 443
HL+KVADFGLAR+++ + YTA AGAKFPIKWTAPE LAY FS+KSDVWAFGILLWEIAT
Sbjct: 60 HLLKVADFGLARMVQGEIYTAQAGAKFPIKWTAPESLAYVKFSSKSDVWAFGILLWEIAT 119
Query: 444 YGMSPYPGVDLADVYHMLEK 463
YG SPYPGVDL VY LE+
Sbjct: 120 YGCSPYPGVDLQHVYGKLEQ 139
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 217 bits (531), Expect = 4e-55
Identities = 122/331 (36%), Positives = 186/331 (56%), Gaps = 19/331 (5%)
Query: 125 VTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 184
+T SL W+HG + R LL+ +G FLVRE+ + +++ G H+
Sbjct: 425 MTTNKSLVDEEWFHGVLPREEVVRLLTQ--DGDFLVRETTRNDECQTVLSVCWGGHKHFI 482
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWE 244
+ A+G Y F ++ +L+ + +G P RS ++ P + WE
Sbjct: 483 VQTTAEGH-YRFEGPAFPSIRDLILYQYTSG--------LPVTGRSGALLYKPIPRERWE 533
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMA--LKDFLEEASIMKEMR 302
++ D+V+ K+G G +GDVY A K N VAVKT + K FL+E I+K+
Sbjct: 534 LNNDDVVLLDKIGRGNFGDVYRAQLKNSNDVVAVKTCRVTLPEDHKKKFLQEGRILKQYD 593
Query: 303 HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSY 362
HPN+V+L+G+C ++ P I+ E + G+LL +LR ++ LM M A+GM Y
Sbjct: 594 HPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLR---KKTALTDAQLMKMCLDAAAGMRY 650
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEGLA 421
LES++ IHRDLAARNCLVG N++VK++DFG++R ++ Y G K PIKWTAPE L
Sbjct: 651 LESKNCIHRDLAARNCLVGYNNVVKISDFGMSR--EEEEYIVSDGMKQIPIKWTAPEALN 708
Query: 422 YNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
+ +++ DVW++GIL WEI + G +PY G+
Sbjct: 709 FGKYTSLCDVWSYGILCWEIFSRGGTPYSGL 739
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 215 bits (526), Expect = 2e-54
Identities = 111/265 (41%), Positives = 162/265 (61%), Gaps = 11/265 (4%)
Query: 201 FGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQ 260
F T+ +L+ HH + +IT+ K + P+ W ++ D+V+ LG G
Sbjct: 510 FTTIPQLIEHH-FSSKQVITK------KSGVVLLNPVVKDKKWILNHEDVVLGELLGKGN 562
Query: 261 YGDVYEAAWKRGNITVAVKTLKDDTMA-LK-DFLEEASIMKEMRHPNLVQLLGVCTREPP 318
+G+V++ +R VAVKT K+D + LK FL EA I+K+ HPN+V+L+GVCT+ P
Sbjct: 563 FGEVFKGTLQRDKTPVAVKTCKEDLPSELKIRFLSEARILKQYDHPNIVKLIGVCTQRQP 622
Query: 319 FYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNC 378
YI+ E + G+ L YLR E L+ A A+GM+YLES++ IHRDLAARNC
Sbjct: 623 IYIVMELVPGGDFLSYLRKKKDELKTKQ--LLRFAVDAAAGMAYLESKNCIHRDLAARNC 680
Query: 379 LVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILL 438
LVG+N+ +K++DFG++R D Y++ + PIKWTAPE L Y +S++SDVW++GILL
Sbjct: 681 LVGDNNALKISDFGMSRQEDDGIYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSYGILL 740
Query: 439 WEIATYGMSPYPGVDLADVYHMLEK 463
WE + GM PYPG+ +EK
Sbjct: 741 WETFSLGMCPYPGMTNQQAREQVEK 765
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 210 bits (514), Expect = 5e-53
Identities = 105/243 (43%), Positives = 152/243 (62%), Gaps = 7/243 (2%)
Query: 225 PAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDD 284
P K+S + P D W ++ D+V+ ++G G +G+V+ + N VAVK+ ++
Sbjct: 466 PLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRET 525
Query: 285 TMA-LK-DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-GARE 341
LK FL+EA I+K+ HPN+V+L+GVCT++ P YI+ E + G+ L +LR GAR
Sbjct: 526 LPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARL 585
Query: 342 CVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT 401
V L+ M A+GM YLES+ IHRDLAARNCLV E +++K++DFG++R D
Sbjct: 586 RVK---TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGV 642
Query: 402 YTAHAGAK-FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHM 460
Y A G++ P+KWTAPE L Y +S++SDVW+FGILLWE + G SPYP +
Sbjct: 643 YAASGGSRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREF 702
Query: 461 LEK 463
+EK
Sbjct: 703 VEK 705
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 210 bits (512), Expect = 8e-53
Identities = 120/327 (36%), Positives = 183/327 (55%), Gaps = 21/327 (6%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRES-ESSPGQRSISLRYEGRVYHYRINEDA 189
L + W+HG + R LL + G FLVRE+ + Q +S+ + G H+ + A
Sbjct: 823 LHEEEWFHGVLPREEVVRLLRN--EGDFLVRETTRNDESQTVLSVCWNGHK-HFIVQTTA 879
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTD 249
+G Y F ++ EL+ H Q P RS + + WE+ D
Sbjct: 880 EGH-YRFEGPAFPSIQELIVHQY--------QSELPVTGRSGAVLRKPVLRERWELSNDD 930
Query: 250 IVMKHKLGGGQYGDVYEAAWKRG-NITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNL 306
+++ K+G G +GDVY+A K N VAVKT + + FL+E I+K+ HPN+
Sbjct: 931 VILLDKIGRGNFGDVYKAKLKSSKNTLVAVKTCRMTLPEEQKRKFLQEGRILKQYDHPNI 990
Query: 307 VQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESR 366
V+L+G+C ++ P I+ E ++ G+LL +LR A G +M M A+GM YLES+
Sbjct: 991 VKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTL--GQRQMMGMCRDAAAGMRYLESK 1048
Query: 367 SFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEGLAYNTF 425
+ IHRDLAARNCL+G ++VK++DFG++R ++ Y G K PIKWTAPE L + +
Sbjct: 1049 NCIHRDLAARNCLIGSENIVKISDFGMSR--EEEEYIVSGGMKQIPIKWTAPEALNFGKY 1106
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGV 452
++ DVW++GIL+WEI + G +PY G+
Sbjct: 1107 TSLCDVWSYGILVWEIFSRGDTPYSGM 1133
>UniRef50_Q4RNX3 Cluster: Chromosome 10 SCAF15009, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 10 SCAF15009, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 466
Score = 208 bits (508), Expect = 2e-52
Identities = 142/400 (35%), Positives = 221/400 (55%), Gaps = 47/400 (11%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLT-GAVGWVPSNYVTPVNSL 131
L VA+Y + + L +KG++++I++ + S EW A +LT G G++P N++ ++++
Sbjct: 54 LVVAIYSYNPKHDGDLGFEKGDKLKIINKDDS-EWYLAESLTTGQRGYIPYNFIA-MSTM 111
Query: 132 EKHSWYHGPISRN-AAEYLLSSG-INGSFLVRESESSPGQRSISLR-YEGR---VYHYRI 185
E +W+ ISRN A L++ G GSFLVRESE++PG S+S+R ++ V HYRI
Sbjct: 112 ETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDNNGDGVKHYRI 171
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAP--PDHW 243
+G Y+T++ F +L ELV H+S DGL T+L+ P ++ P P D W
Sbjct: 172 RNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPCQSKA-----PQKPWWQDEW 226
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRH 303
EI R + ++ KLG GQ+G+V+ + VA+K LK TM+++ FL EA++MK ++H
Sbjct: 227 EIPRESLKLERKLGAGQFGEVWMGVYNNER-RVAIKCLKIGTMSVEAFLAEANMMKNLQH 285
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
LV+L V T+EP YI+TE+M G+L++ Y+ T S +S
Sbjct: 286 ARLVRLFAVVTQEP-IYIVTEYMENGSLVD-----------------YLKTTEGSSLSM- 326
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYN 423
+ I AR L+ + + F L ++ +T + K A + + +
Sbjct: 327 --NTLIDMASQARTLLL---YCTIIVLFRLPQI-----FTHRKVSLLMFKKNA-KAINFG 375
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TFS KSDVW+FGILL EI TYG PYPG+ +V LE+
Sbjct: 376 TFSIKSDVWSFGILLTEIVTYGRIPYPGMSNPEVIQQLER 415
>UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12;
Tetrapoda|Rep: Arg protein-tyrosine kinase - Xenopus
laevis (African clawed frog)
Length = 721
Score = 204 bits (497), Expect = 5e-51
Identities = 90/108 (83%), Positives = 99/108 (91%)
Query: 356 IASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWT 415
I+S M YLE ++FIHRDLAARNCLVGENH+VKVADFGL+RLM DTYTAHAGAKFPIKWT
Sbjct: 1 ISSAMEYLERKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 60
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE LAYNTFS KSDVWAFG+LLWEIATYGMSPYPG+DL+ VY +LEK
Sbjct: 61 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 108
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 200 bits (489), Expect = 5e-50
Identities = 118/329 (35%), Positives = 183/329 (55%), Gaps = 26/329 (7%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRES-ESSPGQRSISLRYEGRVYHYRINEDA 189
L + W+HG + R LL++ +G FLVRE+ + Q +S+ + G H+ +
Sbjct: 955 LYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGHK-HFIVQTTG 1011
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTD 249
+G + F ++ EL+ H ++L P +S + + WE+ D
Sbjct: 1012 EGN-FRFEGPPFASIQELIMHQ------YHSEL--PVTVKSGAILRRPVCRERWELSNDD 1062
Query: 250 IVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKD-----FLEEASIMKEMRHP 304
+V+ ++G G +GDVY+A K + VAVKT + M L D FL+E I+K+ HP
Sbjct: 1063 VVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR---MTLPDEQKRKFLQEGRILKQYDHP 1119
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLE 364
N+V+L+G+C ++ P I+ E + G+LL YLR + M M A+GM YLE
Sbjct: 1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ--MGMCRDAAAGMRYLE 1177
Query: 365 SRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEGLAYN 423
S++ IHRDLAARNCLV H VK++DFG++R ++ Y G K P+KWTAPE L +
Sbjct: 1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFG 1235
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGV 452
+++ DVW++GIL+WEI + G +PY G+
Sbjct: 1236 KYTSLCDVWSYGILMWEIFSKGDTPYSGM 1264
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 200 bits (487), Expect = 8e-50
Identities = 96/229 (41%), Positives = 147/229 (64%), Gaps = 9/229 (3%)
Query: 228 KRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMA 287
KR++ + P D W ++ D+++ +G G +G+V+ + N VAVK +++ A
Sbjct: 469 KRTEIVLKKPIPKDKWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTPVAVKACRENLPA 528
Query: 288 L---KDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVP 344
K +E A I+K+ HPN+V+L+GVCT++ P YII E + G+ L +LR
Sbjct: 529 EHKNKFLMEAARILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTEGHNLKS 588
Query: 345 GAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA 404
+L+ MA +ASG++YLES+ IHRD+AARNCLVGE +VK++DFG++R +D Y+A
Sbjct: 589 S--MLIRMAENVASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSREEQDGVYSA 646
Query: 405 HAGAK-FPIKWTAPEGLAYNT---FSTKSDVWAFGILLWEIATYGMSPY 449
G K P+KWTAPE L Y + ++T+SDVW+FG+LLWE + G++PY
Sbjct: 647 TGGMKQIPVKWTAPEALNYGSPGRYTTESDVWSFGVLLWETFSRGVTPY 695
>UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase
LCK; n=11; Coelomata|Rep: Proto-oncogene
tyrosine-protein kinase LCK - Homo sapiens (Human)
Length = 516
Score = 200 bits (487), Expect = 8e-50
Identities = 100/194 (51%), Positives = 137/194 (70%), Gaps = 6/194 (3%)
Query: 272 GNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNL 331
G+ VAVK+LK +M+ FL EA++MK+++H LV+L V T+EP YIITE+M G+L
Sbjct: 273 GHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSL 331
Query: 332 LEYLR--AGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVA 389
+++L+ +G + + L+ MA QIA GM+++E R++IHRDL A N LV + K+A
Sbjct: 332 VDFLKTPSGIKLTINK---LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIA 388
Query: 390 DFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
DFGLARL+ D+ YTA GAKFPIKWTAPE + Y TF+ KSDVW+FGILL EI T+G PY
Sbjct: 389 DFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPY 448
Query: 450 PGVDLADVYHMLEK 463
PG+ +V LE+
Sbjct: 449 PGMTNPEVIQNLER 462
Score = 99.5 bits (237), Expect = 2e-19
Identities = 60/148 (40%), Positives = 89/148 (60%), Gaps = 10/148 (6%)
Query: 73 LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLT-GAVGWVPSNYVTPVNSL 131
L +AL+ ++ + L +KGEQ+RI+ +SGEW +A +LT G G++P N+V NSL
Sbjct: 123 LVIALHSYEPSHDGDLGFEKGEQLRILE--QSGEWWKAQSLTTGQEGFIPFNFVAKANSL 180
Query: 132 EKHSWYHGPISRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HYR 184
E W+ +SR AE LL+ G +GSFL+RESES+ G S+S+R +G V HY+
Sbjct: 181 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 240
Query: 185 INEDADGKVYVTSESKFGTLAELVHHHS 212
I +G Y++ F L ELV H++
Sbjct: 241 IRNLDNGGFYISPRITFPGLHELVRHYT 268
>UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 618
Score = 198 bits (483), Expect = 3e-49
Identities = 139/422 (32%), Positives = 222/422 (52%), Gaps = 40/422 (9%)
Query: 66 HEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYV 125
H E + ++ + F A ++++++G+ + ++ + W A G+VP ++V
Sbjct: 135 HSEPEEKMLIVENRFLAQTPKEMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHV 194
Query: 126 TPVNSLEKHSWYHGPISRNAAEY-LLSSGIN-GSFLVRESESSPG-----QRSISLRYEG 178
V + + W+ G IS AE ++ + GSFL+RE+ + + S + +
Sbjct: 195 --VYAEYREPWFAGNISSILAEQRVMQPQLPIGSFLIRENSKTDTFVLVVRSSHNESPQA 252
Query: 179 RVYHYRINEDADG--KVYVTSESKFGTLAELVHHHS---VAGD-GLITQLLYPAPKRSKP 232
+ + R N++ + + FG+L +LV+H+S V G+ + T+L AP +
Sbjct: 253 YIIYRRPNQEGFEIRDNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAPPLPEQ 312
Query: 233 TVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDD---TMALK 289
T + H ++R+++ ++G GQ+G+VY A WK + VAVK+LK D +A
Sbjct: 313 TEYMAMKKIH--VNRSEVRRVKEIGRGQFGEVYLAKWK--GVDVAVKSLKPDHSEQLANT 368
Query: 290 DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVP----- 344
FLEEA + ++ H N++ LL VC + P+ IITEFM+ G+LL +L+ + P
Sbjct: 369 QFLEEAKTLTKLSHQNVIHLLAVCDTDKPYLIITEFMTNGSLLAWLQKLTKTLPPIPLMS 428
Query: 345 ------GAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENH-----LVKVADFGL 393
++ ++ Q+ASGM YL + +HRDLAARN LVG LVKVADFGL
Sbjct: 429 EETGRKNVLIGASISAQVASGMDYLSANKIVHRDLAARNVLVGTVSSNGVPLVKVADFGL 488
Query: 394 ARL--MRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
AR + D+ Y P KW APE F+TK+DVW++GILLWEI T G +PY G
Sbjct: 489 ARKTDVGDENYVMKTDNMLPWKWMAPECFDEQIFNTKTDVWSYGILLWEIGTLGKTPYRG 548
Query: 452 VD 453
D
Sbjct: 549 WD 550
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 196 bits (477), Expect = 1e-48
Identities = 111/271 (40%), Positives = 156/271 (57%), Gaps = 23/271 (8%)
Query: 215 GDGLITQLLYPAPKRSKPTVFPLAPPD-HWEIDRTDIVMKHKLGGGQYGDVYEA-----A 268
GDGL+ L +PPD WE R+ + ++ LG G++G V A A
Sbjct: 465 GDGLLIGLESLTAVNRTLLAQKSSPPDPKWEFPRSRLSIEQVLGEGEFGRVLRAKAQDIA 524
Query: 269 WKRGNITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNLVQLLGVCTREP-PFYIITEF 325
+G TVAVKTLK+D A L D L E ++KE +HPN+++LLG CT P Y+I EF
Sbjct: 525 GWQGQTTVAVKTLKEDASASELADLLSEYQLLKEAQHPNVIRLLGACTTAGGPIYLIIEF 584
Query: 326 MSRGNLLEYLRAG------ARECVPGAVV-------LMYMATQIASGMSYLESRSFIHRD 372
G+L YLR R + V ++ A QI+ GM+YL +HRD
Sbjct: 585 AEFGSLRNYLRRSRHLESEGRPSIDPVVNYTITPRDILSFAWQISKGMAYLADIKLVHRD 644
Query: 373 LAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDV 431
LAARN L+G + K++DFGL R + DD Y + + P+KW APE LA + +++KSDV
Sbjct: 645 LAARNVLLGAGKVCKISDFGLTRDVYEDDAYLKRSKGRVPVKWMAPESLADHVYTSKSDV 704
Query: 432 WAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
W+FG+LLWE+ T G SPYPGVD+ ++Y++L+
Sbjct: 705 WSFGVLLWELVTLGASPYPGVDVHNLYNLLK 735
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 196 bits (477), Expect = 1e-48
Identities = 100/224 (44%), Positives = 137/224 (61%), Gaps = 8/224 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAW--KRGNITVAVKTLK---DDTMALKDFLEEASIM 298
EI I + ++GGG++G VY+ W ++ + +AVKTLK D M DFL EASIM
Sbjct: 529 EIPPKYIKLVEEIGGGEFGTVYKGMWNERKPPVPIAVKTLKPGSSDKMR-DDFLTEASIM 587
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV T+ P II EFM G+L YLR + L+ MA +A+
Sbjct: 588 GQFHHPNVIKLYGVITKVEPAMIIMEFMDNGSLYYYLRHNDEKL--SLQQLLKMACGVAA 645
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPE 418
GM YL ++HRDLAARN LV ++ + KVADFGL+R +D Y G K P++WTAPE
Sbjct: 646 GMQYLSEVGYVHRDLAARNILVSKDEVCKVADFGLSRETTNDEYDVKKGGKIPVRWTAPE 705
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
++Y F+T SDVW++G+LLWE+ +YG PY D V LE
Sbjct: 706 AISYRKFTTASDVWSYGVLLWEVMSYGQQPYEDWDNQMVLDKLE 749
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep:
Eph receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 188 bits (459), Expect = 2e-46
Identities = 96/225 (42%), Positives = 141/225 (62%), Gaps = 11/225 (4%)
Query: 248 TDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKD--DTMALKDFLEEASIMKEMR 302
+D + + G G++G+VY+ K + I VA+KTLK +DFL EASIM +
Sbjct: 576 SDKLQHYSTGRGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFD 635
Query: 303 HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSY 362
HPN+++L GV T+ P IITEFM G L +LR + + L+ M IA+GM Y
Sbjct: 636 HPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT--VIQLVGMLRGIAAGMKY 693
Query: 363 LESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT----YTAHAGAKFPIKWTAPE 418
L +++HRDLAARN LV N + KV+DFGL+R ++DDT YT+ G K P++WTAPE
Sbjct: 694 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 753
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+AY F++ SDVW++GI++WE+ ++G PY + DV + +E+
Sbjct: 754 AIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 798
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 188 bits (458), Expect = 3e-46
Identities = 98/229 (42%), Positives = 141/229 (61%), Gaps = 11/229 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V K + I VA+KTLK +DFL EASIM
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P IITEFM G+L +LR + + L+ M IA+
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT--VIQLVGMLRGIAA 732
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT----YTAHAGAKFPIKW 414
GM YL +++HRDLAARN LV N + KV+DFGL+R + DDT YT+ G K PI+W
Sbjct: 733 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 792
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE + Y F++ SDVW++GI++WE+ +YG PY + DV + +E+
Sbjct: 793 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ 841
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 187 bits (455), Expect = 6e-46
Identities = 102/259 (39%), Positives = 148/259 (57%), Gaps = 33/259 (12%)
Query: 238 APPDHWEIDRTDIVMKHKLGGGQYGDVYEA-----AWKRGNITVAVKTLKDDTMA--LKD 290
AP WE R ++++ LG G++G V A + + G TVAVKTLKDD L D
Sbjct: 731 APDPKWEFPRNRLIIEQTLGEGEFGKVLRAKALNISGQPGLTTVAVKTLKDDARESELND 790
Query: 291 FLEEASIMKEMRHPNLVQLLGVCTREP-PFYIITEFMSRGNLLEYLRAGAR---EC--VP 344
L E ++KE+ HPN+++LLGVCT P Y+I EF G+L YLR EC +P
Sbjct: 791 LLSEYQLLKEVSHPNVIRLLGVCTAPGGPIYLIIEFAEHGSLRNYLRRSRHLKSECGRLP 850
Query: 345 GAVV-------------------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHL 385
+ V ++ A QI GM+YL +HRDLAARN L+ + +
Sbjct: 851 SSTVDENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQI 910
Query: 386 VKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATY 444
K++DFGL R + DD Y + + P+KW APE L+ + ++ KSDVW+FGIL+WE+ T
Sbjct: 911 CKISDFGLTRDIYEDDAYFKRSKGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTL 970
Query: 445 GMSPYPGVDLADVYHMLEK 463
G +PYPG+ + +++H+L +
Sbjct: 971 GATPYPGIAVQNLFHLLRQ 989
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 187 bits (455), Expect = 6e-46
Identities = 109/261 (41%), Positives = 153/261 (58%), Gaps = 24/261 (9%)
Query: 227 PKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW------KRGNIT-VAVK 279
P S + + L WE+ R +++ LG G +G V A K +T VAVK
Sbjct: 449 PMLSGLSEYELPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVK 508
Query: 280 TLKDDTMA--LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR 336
LK D L D + E +MK + +H N++ LLG CT++ P Y+I E+ S+GNL EYLR
Sbjct: 509 MLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLREYLR 568
Query: 337 AG---ARE------CVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGEN 383
A A E CVP ++ L+ A Q+A GM YL S+ IHRDLAARN LV E+
Sbjct: 569 ARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTED 628
Query: 384 HLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIA 442
+++K+ADFGLAR + D Y + P+KW APE L ++ +SDVW+FG+LLWEI
Sbjct: 629 NIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 688
Query: 443 TYGMSPYPGVDLADVYHMLEK 463
T G SPYPGV + +++ +L++
Sbjct: 689 TLGGSPYPGVPMEELFKLLKE 709
>UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=19;
Mammalia|Rep: Ephrin type-A receptor 1 precursor - Homo
sapiens (Human)
Length = 976
Score = 186 bits (453), Expect = 1e-45
Identities = 98/226 (43%), Positives = 142/226 (62%), Gaps = 10/226 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNI---TVAVKTLKDDTMALK--DFLEEASIM 298
E+D +++ +G G++G+VY + + TVA+KTLKD + + +FL EA+IM
Sbjct: 618 ELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIM 677
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HP+++ L GV T+ P IITEFM G L +LR + VPG +V M IAS
Sbjct: 678 GQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQG--IAS 735
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD--DTYTAHAGAKFPIKWTA 416
GM+YL + +++HRDLAARN LV +N KV+DFGL RL+ D TY G K PI+WTA
Sbjct: 736 GMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGG-KIPIRWTA 794
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE +A+ F+T SDVW+FGI++WE+ ++G PY + +V +E
Sbjct: 795 PEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE 840
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 186 bits (452), Expect = 1e-45
Identities = 97/227 (42%), Positives = 142/227 (62%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKD--DTMALKDFLEEASIM 298
EID ++I ++ +G G++G+V + + I VA+K+LK +DFL EASIM
Sbjct: 717 EIDASNIRIERVIGAGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRDFLSEASIM 776
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV TR P IITEFM G+L +L+ + + L+ M IAS
Sbjct: 777 GQFDHPNIIRLEGVVTRCKPVMIITEFMENGSLDTFLKKHDGQFT--VIQLVGMLRGIAS 834
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL S++HRDLAARN LV N + KV+DFGL+R++ DD A+ G K PI+WTA
Sbjct: 835 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 894
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE +AY F++ SDVW++GI++WE+ +YG PY + DV +++
Sbjct: 895 PEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAIDE 941
>UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 7 SCAF14601, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 761
Score = 186 bits (452), Expect = 1e-45
Identities = 96/229 (41%), Positives = 141/229 (61%), Gaps = 11/229 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V K + VA+KTLK +DFL EASIM
Sbjct: 403 EIDVSFVKIEEVIGAGEFGEVCRGRLKIPGKKENYVAIKTLKGGYTDKQRRDFLSEASIM 462
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ +HPN++ L GV T P I+TEFM G L +LR + P + L+ M IAS
Sbjct: 463 GQFQHPNIIHLEGVITASCPVMILTEFMENGALDSFLRLNDSQFTP--IQLVGMLRGIAS 520
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR----DDTYTAHAGAKFPIKW 414
GM YL S++HRDLAARN L+ N + KV+DFGL+R ++ D TYT+ G K PI+W
Sbjct: 521 GMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRW 580
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE +A+ F++ SDVW++GI++WE+ ++G PY + DV + +E+
Sbjct: 581 TAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 629
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 185 bits (451), Expect = 2e-45
Identities = 94/230 (40%), Positives = 143/230 (62%), Gaps = 7/230 (3%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAW--KRGNITVAVKTLK-DDTMALKD-FLEEASIM 298
+EI R + + +G GQ+GDV++ + + + VAVKT K + T AL + FLEEA IM
Sbjct: 431 YEISRELVTLVETIGQGQFGDVHKGIYIDQDEKVEVAVKTCKVESTQALGERFLEEAYIM 490
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
K+ HP++++L+GVCT +PP +I+ E G + +L+ E +++L A Q++
Sbjct: 491 KQFDHPHIIKLIGVCT-DPPIWIVMELAPFGEMRMFLQTHKEELTLASLILY--AYQLSM 547
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPE 418
+SYLES+ F+HRD+AARN LV VK+ DFGL+RL+ D +Y + K PIKW APE
Sbjct: 548 ALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKASKGKLPIKWMAPE 607
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
+ + F++ SDVW FG+ +WEI YG+ P+ GV +V +E + P
Sbjct: 608 SINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLP 657
>UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Tribolium castaneum
Length = 1293
Score = 185 bits (450), Expect = 3e-45
Identities = 103/241 (42%), Positives = 140/241 (58%), Gaps = 20/241 (8%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVY--EAAWK-RGNITVAVKTLK--DDTMALKDFLEEA 295
D WEI R +V+ KLG G +G VY EA + +G + VAVKTLK T DFL EA
Sbjct: 892 DKWEIPRNSVVINRKLGEGAFGTVYGGEANFPDKGWVAVAVKTLKVGSSTEEKLDFLSEA 951
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV------- 348
+MK H N+++LLGVCT+E P Y I EFM G+L +L A R V +
Sbjct: 952 EVMKRFDHKNIIKLLGVCTKEEPIYTIMEFMLYGDLKTFLLA-RRHLVNDKTIEESDEIS 1010
Query: 349 ---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
L MA +A G+SYL ++HRD+A+RNCL+ +VK+ADFG+ R + +D Y
Sbjct: 1011 SKKLTMMALDVARGLSYLAQLKYVHRDVASRNCLINAQRIVKLADFGMTRPMFENDYYKF 1070
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKV 464
P++W +PE LA F+ SDVW++G+LL+EI T+G PY G+ +V LE V
Sbjct: 1071 TRKGMLPVRWMSPESLALGVFTPSSDVWSYGVLLYEIITFGSFPYQGMTNGEV---LEYV 1127
Query: 465 K 465
K
Sbjct: 1128 K 1128
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 184 bits (449), Expect = 3e-45
Identities = 102/237 (43%), Positives = 138/237 (58%), Gaps = 14/237 (5%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKDDTMALK--DFLE 293
D WE R + + + LG G +G V++ K G I VAVKTLK++ + D +
Sbjct: 350 DKWEFPRHRLKVFNILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATERERLDLAQ 409
Query: 294 EASIMKEMR-HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV---PGAVV- 348
E +MK + HPN+V+LLG CT P ++I E++S G L +LRA E PG
Sbjct: 410 ELRVMKNLDPHPNVVRLLGCCTEREPMFVILEYVSGGKLQSFLRASREERNHGGPGLTSR 469
Query: 349 -LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHA 406
L QIA GM YL S+ IHRDLAARN L+ EN KVADFG AR + + Y +
Sbjct: 470 DLTGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKVADFGFARDVAANQIYERKS 529
Query: 407 GAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ PI+W APE L N FS KSD+W+FG+L+WEI T G +PYPG+ A+V +++
Sbjct: 530 EGRLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEVMRRIKE 586
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 184 bits (448), Expect = 4e-45
Identities = 98/229 (42%), Positives = 139/229 (60%), Gaps = 14/229 (6%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V K + + VA+KTLK +DFL EASIM
Sbjct: 636 EIDISCVKIEQVIGAGEFGEVCSGNLKLPGKREMFVAIKTLKTGYTEKQRRDFLSEASIM 695
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P IITEFM G+L +LR L+ M IAS
Sbjct: 696 GQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDAFLRVSIH-----GDQLVGMLRGIAS 750
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT----YTAHAGAKFPIKW 414
GM YL +++HRDLAARN LV N + KV+DFGL+R + DDT YT+ G K PI+W
Sbjct: 751 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 810
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE + Y F++ SDVW++GI++WE+ +YG PY + DV + +E+
Sbjct: 811 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ 859
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 184 bits (447), Expect = 6e-45
Identities = 98/229 (42%), Positives = 138/229 (60%), Gaps = 11/229 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V K R + VA+KTLK +DFL EASIM
Sbjct: 630 EIDISCVKIEEVIGAGEFGEVCRGRLKQAGRREMVVAIKTLKAGYTERQRRDFLAEASIM 689
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV TR P IITEFM G L +LR L+ M +A+
Sbjct: 690 GQFDHPNVIRLEGVLTRSCPVLIITEFMENGALDSFLRLNDGRFT--MTQLVGMLRGVAA 747
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM----RDDTYTAHAGAKFPIKW 414
GM YL +++HRDLAARN LV N + KV+DFGL+R + D TYT+ G K PI+W
Sbjct: 748 GMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLDDTSADPTYTSSLGGKIPIRW 807
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE +A+ F+T SDVW++GI++WE+ +YG PY + DV +E+
Sbjct: 808 TAPEAIAFRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQ 856
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 184 bits (447), Expect = 6e-45
Identities = 107/251 (42%), Positives = 146/251 (58%), Gaps = 23/251 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEA-AWKRGNI----TVAVKTLKDDTMA-- 287
+ L + WEIDR+ I +K +LG G +G V +A A ++ TVAVK LK D
Sbjct: 319 YELPIDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENE 378
Query: 288 LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--------- 337
L D L E MK + H N++ L+G CT+ P Y++ EF GNL ++LR
Sbjct: 379 LADLLSEMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRS 438
Query: 338 ---GARECVPGAVVLMYM--ATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
+ P +V ++ A QIA GM YL + IHRDLAARN LVGE++++K+ADFG
Sbjct: 439 RSDSSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFG 498
Query: 393 LARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
LAR +RD D Y + PIKW A E L ++T+SDVW FGILLWEI T G SPYPG
Sbjct: 499 LARNVRDMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPG 558
Query: 452 VDLADVYHMLE 462
+ + ++ +L+
Sbjct: 559 IPVEKLFELLK 569
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 184 bits (447), Expect = 6e-45
Identities = 107/251 (42%), Positives = 146/251 (58%), Gaps = 23/251 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEA-AWKRGNI----TVAVKTLKDDTMA-- 287
+ L + WEIDR+ I +K +LG G +G V +A A ++ TVAVK LK D
Sbjct: 104 YELPIDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENE 163
Query: 288 LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--------- 337
L D L E MK + H N++ L+G CT+ P Y++ EF GNL ++LR
Sbjct: 164 LADLLSEMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRS 223
Query: 338 ---GARECVPGAVVLMYM--ATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
+ P +V ++ A QIA GM YL + IHRDLAARN LVGE++++K+ADFG
Sbjct: 224 RSDSSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFG 283
Query: 393 LARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
LAR +RD D Y + PIKW A E L ++T+SDVW FGILLWEI T G SPYPG
Sbjct: 284 LARNVRDMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPG 343
Query: 452 VDLADVYHMLE 462
+ + ++ +L+
Sbjct: 344 IPVEKLFELLK 354
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 183 bits (446), Expect = 8e-45
Identities = 96/227 (42%), Positives = 139/227 (61%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDDTM--ALKDFLEEASIM 298
EID + I ++ +G G++G+V K + I VA+KTLK + KDFL EASIM
Sbjct: 582 EIDPSRIRIERVIGAGEFGEVCSGRLKTPAKKEIPVAIKTLKGGYVDRQRKDFLREASIM 641
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV T+ P I+ E+M G+L +LR + + L+ M IAS
Sbjct: 642 GQFDHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFLRKHDGQFT--VIQLVGMLRGIAS 699
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL ++HRDLAARN LV N + KV+DFGL+R++ DD A+ G K PI+WTA
Sbjct: 700 GMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 759
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE +A+ FS+ SD W++GI++WE+ +YG PY + DV +E+
Sbjct: 760 PEAIAFRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEE 806
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 183 bits (446), Expect = 8e-45
Identities = 97/214 (45%), Positives = 133/214 (62%), Gaps = 11/214 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDDTMALK--DFLEEASIM 298
EID + I + +G G++G+V+ K +G + VA+KTLK + DFL EASIM
Sbjct: 676 EIDPSAISKQKVIGVGEFGEVFRGVMKTRGQGEVNVAIKTLKPGYSEKQRLDFLSEASIM 735
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ I+TE+M G L YL+ E P +V M IA+
Sbjct: 736 GQFSHPNIIHLEGVVTKFKHIMIVTEYMDNGALDTYLKGRDGEIPPYQLVGMLRG--IAA 793
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD---TYTAHAGAKFPIKWT 415
GM YL + S++HRDLAARN LV N KV+DFGL+R++ DD TYT G K PI+WT
Sbjct: 794 GMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDDEGTYTTRGG-KIPIRWT 852
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
APE +AY F++ SDVW+FGI++WE+ +G PY
Sbjct: 853 APEAIAYRKFTSASDVWSFGIVMWEVMAFGERPY 886
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 183 bits (445), Expect = 1e-44
Identities = 101/229 (44%), Positives = 139/229 (60%), Gaps = 12/229 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRG-----NITVAVKTLKDDTM--ALKDFLEEAS 296
EID I ++ +GGG++GDV K +I VA+KTLK + A DFL EAS
Sbjct: 735 EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
IM + HPN++ L GV TR P IITE+M G+L +LR + + L+ M I
Sbjct: 795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQ--TLQLIVMLRGI 852
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD--DTYTAHAGAKFPIKW 414
ASGMSYL +++HRDLAARN LV + K+ADFGL+R + + D YT G K P++W
Sbjct: 853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGG-KIPVRW 911
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE +A+ F++ SDVW++G++LWE+ +YG PY DV +EK
Sbjct: 912 TAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEK 960
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 183 bits (445), Expect = 1e-44
Identities = 109/245 (44%), Positives = 145/245 (59%), Gaps = 24/245 (9%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEA-------AWKRGNITVAVKTLKDDTMA--LKDFLE 293
WE R +V+ LG G +G V A A TVAVK LKD+ L D +
Sbjct: 692 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 751
Query: 294 EASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-----------GAR- 340
E +MK + RH N++ LLGVCT+E P Y+I E ++GNL E+LRA G R
Sbjct: 752 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 811
Query: 341 -ECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD 399
E VL+ A Q+A GM YLESR IHRDLAARN LV E++++K+ADFGLAR +
Sbjct: 812 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 871
Query: 400 -DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
D Y + + P+KW APE L ++ +SDVW+FGILLWEI T G SPYPG+ + +++
Sbjct: 872 IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 931
Query: 459 HMLEK 463
+L +
Sbjct: 932 SLLRE 936
>UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=2; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 1071
Score = 182 bits (444), Expect = 1e-44
Identities = 95/229 (41%), Positives = 140/229 (61%), Gaps = 11/229 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V + + I VA+KTLK +DFL EASIM
Sbjct: 718 EIDISCVKIEQVIGAGEFGEVCSGNLRQPGKREILVAIKTLKVGYTERQRRDFLSEASIM 777
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P IITEFM G+L +LR + + L+ M IA+
Sbjct: 778 GQFDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFT--VIQLVGMLRGIAA 835
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT----YTAHAGAKFPIKW 414
G+ YL +++HRDLAARN LV N + KV+DFGL+R + DDT YT+ G K PI+W
Sbjct: 836 GVKYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 895
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE + Y F++ SD W++GI++WE+ +YG PY + DV + +E+
Sbjct: 896 TAPEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQ 944
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 182 bits (444), Expect = 1e-44
Identities = 105/236 (44%), Positives = 135/236 (57%), Gaps = 19/236 (8%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVY--EAAWKRGN---ITVAVKTLKDDTMAL--KDFLE 293
D WE R + + LG G +G V+ EA GN TVAVKTLK+ + KD L
Sbjct: 461 DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLS 520
Query: 294 EASIMKEMR-HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG------- 345
E +MK + H N+V LLG CT + P ++I E+++RG L YLR+ E G
Sbjct: 521 ELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSN 580
Query: 346 ---AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDT 401
+ L Q+A GM YL SR IHRDLAARN L+ ++H KVADFG AR ++
Sbjct: 581 VLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKI 640
Query: 402 YTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
Y + K PI+W A E L N FS KSD+W+FGIL+WEI T G +PYPG+ ADV
Sbjct: 641 YERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADV 696
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 182 bits (443), Expect = 2e-44
Identities = 107/266 (40%), Positives = 144/266 (54%), Gaps = 15/266 (5%)
Query: 211 HSVAGDGLITQLLYPAPKRSKPTVFPLAPPDH--------WEIDRTDIVMKHKLGGGQYG 262
H + +G +++ P K+ K V P D EID T I + +GGG++G
Sbjct: 370 HLIYANGTNGEVILPHIKKVKTYVDPFTYEDPNQAVKEFATEIDATQIRILEVIGGGEFG 429
Query: 263 DVYEAAW---KRGNITVAVKTLKDDTMAL--KDFLEEASIMKEMRHPNLVQLLGVCTREP 317
DV + I VAVKTLK DFL EASIM + HPN+++LLGV T+
Sbjct: 430 DVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTR 489
Query: 318 PFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARN 377
P I+TEFM G+L +YLR L+ M + GM +L +F+HRDLAARN
Sbjct: 490 PAMIVTEFMENGSLDKYLRENDGRFT--VTQLLGMMRGVGFGMRFLSEMNFVHRDLAARN 547
Query: 378 CLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGIL 437
LV E+ + KVADFGL+R D G K PI+WTAPE + Y F++ SDVW+ G++
Sbjct: 548 ILVNEHLVCKVADFGLSRRKELDGAYETRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVV 607
Query: 438 LWEIATYGMSPYPGVDLADVYHMLEK 463
+WEI +YG PY DV +EK
Sbjct: 608 MWEIMSYGERPYWNWPNQDVIKAVEK 633
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 182 bits (443), Expect = 2e-44
Identities = 94/226 (41%), Positives = 141/226 (62%), Gaps = 9/226 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDDTMALK--DFLEEASIM 298
E+D + + M++ +G G++G+VY + + + I VA+KTLK + +FL EA+IM
Sbjct: 610 ELDVSCVTMENVIGEGEFGEVYRGSLRLPGKERIVVAIKTLKSTYSDSQWWNFLREATIM 669
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+V L GV T+ P IITE+M G L +LR + P V L+ M IAS
Sbjct: 670 GQFNHPNIVHLEGVVTKRRPMMIITEYMENGALDTFLRENEEKFSP--VQLVNMLQGIAS 727
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM+YL +++HRDLAARN LV + KV+DFGL+R++ +D + G K PI+WTA
Sbjct: 728 GMTYLSEHNYVHRDLAARNILVTRSLQCKVSDFGLSRILENDAEGTYETKGGKIPIRWTA 787
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE +A+ F++ SDVW+FGI++WE+ ++G PY + +V LE
Sbjct: 788 PEAIAHRIFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSLE 833
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 182 bits (443), Expect = 2e-44
Identities = 113/349 (32%), Positives = 188/349 (53%), Gaps = 24/349 (6%)
Query: 133 KHSWYHGPISRNAAEYLLSS-GI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINEDAD 190
K W+HG ISR +E + + G+ +G FLVRE + ++ + + +YHY + +
Sbjct: 160 KQLWFHGAISREESEQRMKAFGLRDGLFLVRE-RTEVNSFALCVAVKNDIYHYLLEMNTL 218
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLL-YPAPKRSKPTVFPLAPP-----DHW- 243
G++ + + KF L ++V H+S DGL+ L+ A R + P+ H
Sbjct: 219 GQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPGAVVKRVKHGP 278
Query: 244 -EIDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITVAVKTLKDDTMALK---DFLEEA 295
I+ +++ + +LG G +G V ++ N + A+K LK + L EA
Sbjct: 279 RRIEDSELSTQGELGAGTFGTVRLGVYRPKNGEPEVQCALKYLKQSEELPNQKAEILREA 338
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQ 355
M + H N+V+L G+C +P ++ E +G L ++LR R P + ++ MA Q
Sbjct: 339 DAMAALDHCNIVRLFGICVGDP-ICLVMELARQGPLNKFLRK--RPTFP-VIKILNMALQ 394
Query: 356 IASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAHAGAKFPIK 413
++ GM+YLE F+HRDLAARN LV ++ VK++DFG++R + + Y A ++P+K
Sbjct: 395 VSRGMAYLEEVRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAETAGRWPLK 454
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
W APE + Y F +KSDVW++G+ +WE ++G PY G+ D+ MLE
Sbjct: 455 WYAPECIYYAKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLE 503
Score = 85.0 bits (201), Expect = 4e-15
Identities = 43/100 (43%), Positives = 62/100 (62%), Gaps = 2/100 (2%)
Query: 128 VNSLEKHSWYHGPISRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEGRVYHYRI 185
+ L K WYHG ISR AE LL + ++GSFLVR+S ++ G+ +SL ++G+ YHY I
Sbjct: 1 MTDLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYII 60
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYP 225
+ DG V + +KF + EL+ +H+ DGLIT L P
Sbjct: 61 SRHPDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQP 100
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=8; Clupeocephala|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 714
Score = 182 bits (442), Expect = 2e-44
Identities = 95/216 (43%), Positives = 133/216 (61%), Gaps = 12/216 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDDTMALKD--FLEEASIM 298
EID T + ++ +G Q+G+V ++ R + VAVKTL+ + FL EA ++
Sbjct: 347 EIDPTHLKIEEVIGAAQFGEVSRGRYRPLGRREVLVAVKTLRWGASDREKGMFLSEAGVL 406
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV TR PP I+TEFM G L +LR + + L+ M I +
Sbjct: 407 GQFDHPNVLKLEGVITRTPPERIVTEFMENGPLDSFLRENEGQF--SVLQLVGMLRGIGA 464
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD-----DTYTAHAGAKFPIK 413
GM YL R+F+HRDLAARN LV N + KV+DFGL+RLMR TYTA G+K P++
Sbjct: 465 GMRYLAERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNIPTYTASLGSKIPVR 524
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
WTAPE + FS+ SDVW+FG+L+WE+ +YG PY
Sbjct: 525 WTAPEAFQHRKFSSASDVWSFGVLMWEVMSYGERPY 560
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 182 bits (442), Expect = 2e-44
Identities = 93/223 (41%), Positives = 139/223 (62%), Gaps = 15/223 (6%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGN-----ITVAVKTLKDDTMALK--DFLEEAS 296
++ R + + + LG G +G+VY A ++ + + VAVKTL++D K DFL+EA+
Sbjct: 1187 QVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAA 1246
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV----LMYM 352
IM + HPN+V L+GVC P+YI+ E ++ G+L ++LR +++ L++
Sbjct: 1247 IMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFC 1306
Query: 353 ATQIASGMSYLESRSFIHRDLAARNCLV---GENHLVKVADFGLAR-LMRDDTYTAHAGA 408
A +A G Y+ES+ FIHRD+AARNCL+ G +VK+ADFG++R + R D Y A
Sbjct: 1307 ALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKA 1366
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
PIKW PE F++K+DVW+FGILLWE+ + G SPYPG
Sbjct: 1367 MLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPG 1409
>UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1048
Score = 182 bits (442), Expect = 2e-44
Identities = 98/225 (43%), Positives = 137/225 (60%), Gaps = 12/225 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT----VAVKTLKD--DTMALKDFLEEASI 297
EID + I ++ +GGG++G+V + N VA+KTLK T DFL EASI
Sbjct: 637 EIDASYIGIEEVIGGGEFGEVCLGRMRLPNSKKEHDVAIKTLKAGYSTQQKLDFLGEASI 696
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + HPN+++L GV T+ P IITE+M G+L +LR E + L+ + IA
Sbjct: 697 MGQFDHPNVIRLEGVVTKSQPHMIITEYMENGSLDTFLRKHDGEFT--VIQLVGILRNIA 754
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR---DDTYTAHAGAKFPIKW 414
+GM YL ++HRDLAARN LV + KV+DFGL+R++ D TYT G K PI+W
Sbjct: 755 AGMKYLSDMGYVHRDLAARNILVNAQLICKVSDFGLSRVLEESSDSTYTTRGG-KIPIRW 813
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
TAPE + Y F++ SDVW++GI++WE+ +YG PY G+ DV H
Sbjct: 814 TAPEAINYRKFTSASDVWSYGIVMWEVMSYGERPYWGMSNQDVIH 858
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 182 bits (442), Expect = 2e-44
Identities = 101/246 (41%), Positives = 149/246 (60%), Gaps = 25/246 (10%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEA-AWKRGNI----TVAVKTLKDDTMA--LKDFLE 293
+ WE+DR+ I + LG G +G V +A A N+ VAVK L +D L D +
Sbjct: 265 EEWELDRSQISLLGILGEGAFGRVVKADAIGLPNMPYRCNVAVKMLXEDATEHELADLVS 324
Query: 294 EASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG------- 345
E +MK + +H N++ L+G CT++ P +++ E+ S+GNL ++LRA R +P
Sbjct: 325 EMEVMKTIGQHVNIINLIGACTQKGPLFVVVEYASQGNLRQFLRA--RRPIPEYANPLTE 382
Query: 346 -------AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR 398
V L+ + Q+A GM YLES+ IHRDLAARN LV +NH++K+ADFGLAR +
Sbjct: 383 PPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDIH 442
Query: 399 D-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
D D Y + P+KW A E L ++ +SDVWA+GIL+WEI T+G SPYPG+ L +
Sbjct: 443 DIDYYRKTTDGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKL 502
Query: 458 YHMLEK 463
+ +L++
Sbjct: 503 FELLKE 508
>UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31;
n=4; Caenorhabditis|Rep: Probable tyrosine-protein
kinase kin-31 - Caenorhabditis elegans
Length = 437
Score = 182 bits (442), Expect = 2e-44
Identities = 120/348 (34%), Positives = 183/348 (52%), Gaps = 42/348 (12%)
Query: 126 TPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ-RS--ISLRYEGR--- 179
TP ++EK +++HG I R LL + NG ++VR S+ PG+ RS +S+ + +
Sbjct: 10 TPTPTIEKEAYFHGLIQREDVFQLLDN--NGDYVVRLSDPKPGEPRSYILSVMFNNKLDE 67
Query: 180 ---VYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFP 236
V H+ IN + K +V + F T+ +++ H+ + ++ P R +
Sbjct: 68 NSSVKHFVINS-VENKYFVNNNMSFNTIQQMLSHYQKSRTEILEACKILHPVRRQ----- 121
Query: 237 LAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAA--WKRGN--ITVAVKTLKDDTMA---LK 289
WE+D +IV++ KLG G +G+V +KRG + VAVK +K D + +K
Sbjct: 122 -----FWELDHGNIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVKQVKTDGIGKDQIK 176
Query: 290 DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVL 349
DFL EA M+ + HPN+V+ LG+ + P +++ E + G L YL+ E +P
Sbjct: 177 DFLMEARTMRNLGHPNIVRFLGIAVLQEPLFLVMELATGGALDSYLK--HNELLP-IDKR 233
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK 409
M Q A G+ Y+ + +HRD+AARNCL G+ VK++DFGL R R Y H K
Sbjct: 234 HEMLLQAAWGLEYIHGKPMLHRDIAARNCLYGDGK-VKISDFGLTR--RGTIYQLHPETK 290
Query: 410 FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
PI+W A S K+DVWA+GIL WEI G PYPG+ +V
Sbjct: 291 SPIRWLA-------VCSQKTDVWAYGILCWEIFNNGAEPYPGLTANEV 331
>UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1006
Score = 180 bits (439), Expect = 6e-44
Identities = 99/236 (41%), Positives = 142/236 (60%), Gaps = 18/236 (7%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKD--DTMALKDFLEEASIM 298
EID + I ++ +G G++G+V + + I VA+K+LK +DFL EASIM
Sbjct: 655 EIDVSSIHIERVIGMGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRDFLSEASIM 714
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV TR P IITE+M G+L +LR + + L+ M IAS
Sbjct: 715 GQFDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAFLRKHDGQFT--VIQLVGMLRGIAS 772
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-----------G 407
GM YL S++HRDLAARN LV N + KV+DFGL+R++ DD A+ G
Sbjct: 773 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRENTGTYLSPG 832
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
K PI+WTAPE +AY F+T SDVW++GI++WE+ +YG PY ++ DV +E+
Sbjct: 833 GKIPIRWTAPEAIAYRKFTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEE 888
>UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:
Tyrosine kinase - Homo sapiens (Human)
Length = 600
Score = 180 bits (439), Expect = 6e-44
Identities = 105/230 (45%), Positives = 140/230 (60%), Gaps = 15/230 (6%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW-----KRGNITVAVKTLKDDTMALKDFLEEASIMK 299
IDR +++ LG G+ G VYE W K I VA+KTLK DTMA K+ L+EAS+MK
Sbjct: 237 IDRNLLILGKILGEGEKGTVYEGLWNIPEGKEVKIPVAIKTLKLDTMANKEILDEASVMK 296
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEF---MSRGNL--LEYLRAGARECVPGAVVLMYMAT 354
+P++V+LLG+C Y+ITE+ + R N E R+ E P L+
Sbjct: 297 GFGNPHVVRLLGICMTST-IYVITEYCLLVYRRNKDKAEQHRSNCAELNPPLQTLLKFMV 355
Query: 355 QIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLA-RLMRDDTYTAHAGAKFPIK 413
IA GM YL +R+F+HRDLAARNC++ ++ V VADFGL+ ++ D Y AK P+K
Sbjct: 356 DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK 415
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIAT--YGMSPYPGVDLADVYHML 461
W A E LA + TKSDVWAFG+ +WEIAT GM+PYPGV ++Y L
Sbjct: 416 WIAIESLADRVY-TKSDVWAFGVTMWEIATTLRGMTPYPGVQNHEMYDYL 464
>UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep:
Ephrin receptor - Mus musculus (Mouse)
Length = 819
Score = 180 bits (438), Expect = 7e-44
Identities = 91/227 (40%), Positives = 139/227 (61%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI+ + I ++ +G G++G+V K + + VA+KTLK +DFL EASIM
Sbjct: 485 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 544
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P I+TE+M G+L +L+ + + L+ M IA+
Sbjct: 545 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT--VIQLVGMLRGIAA 602
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL ++HRDLAARN L+ N + KV+DFGL+R++ DD A+ G K PI+WTA
Sbjct: 603 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 662
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE +A+ F++ SDVW++GI++WE+ +YG PY + DV +E+
Sbjct: 663 PEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 709
>UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: Eph
receptor - Manduca sexta (Tobacco hawkmoth) (Tobacco
hornworm)
Length = 1011
Score = 180 bits (438), Expect = 7e-44
Identities = 100/229 (43%), Positives = 140/229 (61%), Gaps = 12/229 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITVAVKTLKDDTM--ALKDFLEEASI 297
EID + I ++ +GGG++GDV K + I VA+KTLK + A +DFL EASI
Sbjct: 641 EIDASCITIEAIIGGGEFGDVCRGKLKLASCGQEIDVAIKTLKPGSTERARRDFLAEASI 700
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + HPN++ L GV T+ P IITEFM G+L +LRA + + + L+ M IA
Sbjct: 701 MGQFEHPNVIFLQGVVTKCNPIMIITEFMENGSLDTFLRANDGKFM--VLQLVGMLRGIA 758
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR---DDTYTAHAGAKFPIKW 414
+GM YL ++IHRDLAARN LV + + K+ADFGL+R + D YT G K P++W
Sbjct: 759 TGMQYLSEMNYIHRDLAARNVLVNSHLVCKIADFGLSREIESTADGAYTTRGG-KIPVRW 817
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE +A+ F++ SDVW+ GI+ WE+ ++G PY DV +EK
Sbjct: 818 TAPEAIAFRKFTSASDVWSMGIVCWEVMSFGERPYWNWSNQDVIKSIEK 866
>UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 1173
Score = 180 bits (437), Expect = 1e-43
Identities = 94/223 (42%), Positives = 136/223 (60%), Gaps = 11/223 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EID + + ++ +G G++G+V + + I VA+KTLK +DFL EASIM
Sbjct: 655 EIDISCVKIEQVIGAGEFGEVCSGNLRQPGKREILVAIKTLKVGYTERQRRDFLSEASIM 714
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P IITEFM G+L +LR + + L+ M IA+
Sbjct: 715 GQFDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFT--VIQLVGMLRGIAA 772
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT----YTAHAGAKFPIKW 414
G+ YL +++HRDLAARN LV N + KV+DFGL+R + DDT YT+ G K PI+W
Sbjct: 773 GVKYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 832
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
TAPE + Y F++ SD W++GI++WE+ +YG PY + DV
Sbjct: 833 TAPEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDV 875
>UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Ephrin
receptor - Apis mellifera (Honeybee)
Length = 996
Score = 180 bits (437), Expect = 1e-43
Identities = 101/229 (44%), Positives = 136/229 (59%), Gaps = 11/229 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTM--ALKDFLEEAS 296
EID I ++ +GGG++GDV K R I VA+KTLK + A DFL EAS
Sbjct: 627 EIDAGYITIEAIIGGGEFGDVCRGKLKLPPDGRTEIDVAIKTLKPGSADKARNDFLTEAS 686
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
IM + HPN++ L GV T+ P IITEFM G+L +LRA + + L+ M I
Sbjct: 687 IMGQFEHPNVIFLQGVVTKSNPVMIITEFMENGSLDTFLRANDGKFQ--VLQLVGMLRGI 744
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKW 414
ASGM YL +++HRDLAARN LV + K+ADFGL+R + T A+ G K P++W
Sbjct: 745 ASGMQYLAEMNYVHRDLAARNVLVNAALVCKIADFGLSREIESATEGAYTTRGGKIPVRW 804
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE +A+ F++ SDVW+ GI+ WE+ +YG PY DV +EK
Sbjct: 805 TAPEAIAFRKFTSASDVWSMGIVCWEVMSYGERPYWNWSNQDVIKSIEK 853
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 180 bits (437), Expect = 1e-43
Identities = 94/228 (41%), Positives = 132/228 (57%), Gaps = 15/228 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMALK--DFL 292
PD WE+ R I M +LG G +G VYE K VA+KT+ + + +FL
Sbjct: 985 PDKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFL 1044
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-------GARECVPG 345
EAS+MKE ++V+LLGV ++ P +I E M+RG+L YLR+ + + P
Sbjct: 1045 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPS 1104
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++ MA +IA GMSYL + F+HRDLAARNC+V E+ VK+ DFG+ R + D Y
Sbjct: 1105 LKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRK 1164
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W +PE L F+T SDVW+FG++LWEIAT PY G+
Sbjct: 1165 GGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGM 1212
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 180 bits (437), Expect = 1e-43
Identities = 103/253 (40%), Positives = 145/253 (57%), Gaps = 24/253 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW-------KRGNITVAVKTLKDDTMA 287
+ L WE R + + LG G +G V A + +TVAVK LKDD
Sbjct: 462 YDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATE 521
Query: 288 --LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA----GAR 340
L D + E +MK + RH N++ LLG CT++ P Y+I E+ S+GNL EYLRA G
Sbjct: 522 KDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 581
Query: 341 ECVPGAVV---------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADF 391
A V L+ Q+A GM YL S+ IHRDLAARN LV E++++K+ADF
Sbjct: 582 YSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADF 641
Query: 392 GLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
GLAR + + D Y + P+KW APE L ++ +SDVW+FG+L+WEI T G SPYP
Sbjct: 642 GLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 701
Query: 451 GVDLADVYHMLEK 463
G+ + +++ +L++
Sbjct: 702 GIPVEELFKLLKE 714
>UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine
protein kinase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tyrosine protein kinase -
Strongylocentrotus purpuratus
Length = 1566
Score = 179 bits (436), Expect = 1e-43
Identities = 100/234 (42%), Positives = 134/234 (57%), Gaps = 18/234 (7%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVY--EAAWKRGN-ITVAVKTLKDDTMALK--DFLEEA 295
D WE+ R ++V+ KLG G +G VY EA VAVKTLK + DFL EA
Sbjct: 1011 DEWEMPRENVVLNRKLGEGAFGTVYGGEALLDDNKWAAVAVKTLKLGASVEEKLDFLSEA 1070
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV------- 348
+MK H N+V LLGVCTR P Y + EFM G+L +L G R V V
Sbjct: 1071 EVMKRFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFL-LGRRHLVGEGVYERNQHVM 1129
Query: 349 ----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD-DTYT 403
L M + IASG+SYL S +++HRDLA RNCLV ++ VK+ DFG+ R + D D Y
Sbjct: 1130 CPDQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRALYDSDYYR 1189
Query: 404 AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
+K P++W APE L F+T SDVW+ G++++E+ T+G PY + A+V
Sbjct: 1190 LGKRSKLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNAEV 1243
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 179 bits (436), Expect = 1e-43
Identities = 94/229 (41%), Positives = 132/229 (57%), Gaps = 5/229 (2%)
Query: 234 VFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTL--KDDTMALKDF 291
V P+ D WEIDR DI + +LG G +G VYE K A+KT+ K + +F
Sbjct: 904 VGPIYVEDDWEIDRNDIEIIRELGKGSFGTVYEGLIKSRQYPCAIKTISEKSSISSKMEF 963
Query: 292 LEEASIMKEMRHPN-LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLM 350
L E S+MK + +++LLG+ +R ++I E M RG+L YLR +
Sbjct: 964 LNEGSVMKSFSETHHVIKLLGIVSRGDRPFVIMELMERGDLKSYLRRCRGPSQNLTTNEI 1023
Query: 351 Y-MATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGA 408
Y MA++IA GM+YL + F+HRDLAARNC+V + VK+ DFG+AR + D Y
Sbjct: 1024 YRMASEIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMARDIYETDYYRKGTAG 1083
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
PI+W APE LA F+T SDVW++G++LWE+AT PY G+ +V
Sbjct: 1084 LLPIRWMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGAEEV 1132
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta
cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence; n=18; Eumetazoa|Rep:
14 days pregnant adult female placenta cDNA, RIKEN
full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence - Mus musculus (Mouse)
Length = 386
Score = 179 bits (436), Expect = 1e-43
Identities = 104/253 (41%), Positives = 146/253 (57%), Gaps = 24/253 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW------KRGNIT-VAVKTLKDDTMA 287
+ L WE+ R +V+ LG G +G V A K +T VAVK LK D
Sbjct: 27 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 86
Query: 288 --LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA----GAR 340
L D + E +MK + +H N++ LLG CT++ P Y+I E+ S+GNL EYL+A G
Sbjct: 87 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 146
Query: 341 ECVP---------GAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADF 391
C + L+ A Q+A GM YL S+ IHRDLAARN LV E++++K+ADF
Sbjct: 147 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMKIADF 206
Query: 392 GLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
GLAR + D Y + P+KW APE L ++ +SDVW+FG+LLWEI T G SPYP
Sbjct: 207 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 266
Query: 451 GVDLADVYHMLEK 463
GV + +++ +L++
Sbjct: 267 GVPVEELFKLLKE 279
>UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1;
Schistosoma mansoni|Rep: Fes-like tyrosine kinase protein
- Schistosoma mansoni (Blood fluke)
Length = 1259
Score = 179 bits (436), Expect = 1e-43
Identities = 101/282 (35%), Positives = 159/282 (56%), Gaps = 18/282 (6%)
Query: 172 ISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSK 231
+S+ + G + G+ + + F T+ EL+ +H + TQ A K
Sbjct: 891 LSVFWHGHRHFILYGGPETGEGWHLEDGHFSTIRELIEYH------MKTQTPVTA-KSGA 943
Query: 232 PTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMAL--- 288
V P++ PD WE+D D+ + K+G G +GDVY + VAVKT + D A
Sbjct: 944 CLVTPISRPD-WELDNRDVQLLQKIGQGNFGDVYRGVYN--GCEVAVKTCRVDMTASDLR 1000
Query: 289 KDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV 348
+ FL+ + HPN+V+L+G+ + P I+ E++ G+LL +LR ++ +P +
Sbjct: 1001 RKFLQGETTALNFNHPNIVKLVGIAVQSYPIMIVMEYVPGGSLLNHLRK-SKNALP-VMK 1058
Query: 349 LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTY-TAHAG 407
L+ M+ A+GM YLE+R+ IHRDLAARNCL+ ++ +K+ADFG++R + Y +
Sbjct: 1059 LLQMSLDAANGMMYLEARNCIHRDLAARNCLISDDGQLKIADFGMSR--EEHIYELSDKR 1116
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
+ PIKWTAPE L ++ K DVW++G+LLWEI T+G PY
Sbjct: 1117 GQIPIKWTAPEALRTGRYTIKCDVWSYGVLLWEIFTFGDVPY 1158
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 179 bits (436), Expect = 1e-43
Identities = 107/267 (40%), Positives = 151/267 (56%), Gaps = 17/267 (6%)
Query: 202 GTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQY 261
G + L HS D + +LY + + + D WE R + + +LG G +
Sbjct: 651 GLYSFLSPFHSYRKDQMPDGVLYASVNPEYMSTSDMYVADEWEFPRDKLEIIRELGKGSF 710
Query: 262 GDVYEAAWK-----RGNIT-VAVKTLKDDTMALKD---FLEEASIMKEMRHPNLVQLLGV 312
G VYE K I+ VA+K+++ + +++D FL EAS+MK + N+V+LLGV
Sbjct: 711 GMVYEGLAKGILPEEEEISRVAIKSVQANA-SMRDRIEFLNEASVMKLIDAHNVVRLLGV 769
Query: 313 CTREPPFYIITEFMSRGNLLEYLRAGARE------CVPGAVVLMYMATQIASGMSYLESR 366
++ P Y+I EFM++G+L +LRA E VP L+ MA +IA GMS+L +R
Sbjct: 770 VSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLPSVPTLEQLLNMAAEIADGMSFLAAR 829
Query: 367 SFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTF 425
++HRDL+ARNCLV KVADFGLAR + + D Y G PI+W APE + F
Sbjct: 830 KYVHRDLSARNCLVSGEGTCKVADFGLARDIYQSDYYRKERGGMLPIRWMAPESVKDGVF 889
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGV 452
SDVW+FGILLWE+AT G PY G+
Sbjct: 890 QASSDVWSFGILLWEMATLGELPYQGL 916
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 179 bits (436), Expect = 1e-43
Identities = 103/235 (43%), Positives = 145/235 (61%), Gaps = 17/235 (7%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN--ITVAVKTLKDDTMA---LKDFLEEASIMK 299
+DR + + LG G++G V E + + + VAVKT+K L+DFL EA MK
Sbjct: 524 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 583
Query: 300 EMRHPNLVQLLGVC----TRE--PPFYIITEFMSRGNL---LEYLRAGAREC-VPGAVVL 349
E HPN+++L+GVC RE P +I FM G+L L Y R G + +P +++
Sbjct: 584 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 643
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGA 408
+MA IASGM YL ++ FIHRDLAARNC++ EN V VADFGL++ + D Y A
Sbjct: 644 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 702
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
K P+KW A E LA +++KSDVW+FG+ +WEIAT G +PYPGV+ +++Y L +
Sbjct: 703 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ 757
>UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10323,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 815
Score = 179 bits (435), Expect = 2e-43
Identities = 96/228 (42%), Positives = 140/228 (61%), Gaps = 11/228 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI + I ++ +G G++G+V + + I VA+KTLK +DFL EASIM
Sbjct: 472 EIHLSSISIERIIGAGEFGEVCSGPLRLPGKREILVAIKTLKAGYTEQQRRDFLWEASIM 531
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV T+ P IITE+M G+L +L+ + + L+ M IAS
Sbjct: 532 GQFNHPNIIRLEGVVTKSKPVMIITEYMENGSLDTFLKKNDGQFT--VIQLVGMLRGIAS 589
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLV-KVADFGLARLMRDDTYTAHA--GAKFPIKWT 415
GM YL ++HRDLAARN LV + HLV KV+DFGL+R + DD A+ G K PI+WT
Sbjct: 590 GMRYLSDMGYVHRDLAARNILV-DGHLVCKVSDFGLSRALEDDPEAAYTTQGGKIPIRWT 648
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE +AY F++ SDVW++G+++WE+ +YG PY + DV +E+
Sbjct: 649 APEAIAYRKFTSASDVWSYGVVMWEVMSYGERPYWDMSNQDVIKAVEE 696
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 179 bits (435), Expect = 2e-43
Identities = 103/253 (40%), Positives = 146/253 (57%), Gaps = 24/253 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW-------KRGNITVAVKTLKDDTMA 287
+ L WE R + + LG G +G V A + +TVAVK LKDD
Sbjct: 354 YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 413
Query: 288 --LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA----GAR 340
L D + E +MK + +H N++ LLG CT++ P Y+I E+ S+GNL EYLRA G
Sbjct: 414 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 473
Query: 341 EC-----VPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADF 391
VP + L+ Q+A GM YL S+ IHRDLAARN LV EN+++K+ADF
Sbjct: 474 YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 533
Query: 392 GLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
GLAR + + D Y + P+KW APE L ++ +SDVW+FG+L+WEI T G SPYP
Sbjct: 534 GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 593
Query: 451 GVDLADVYHMLEK 463
G+ + +++ +L++
Sbjct: 594 GIPVEELFKLLKE 606
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens
(Human)
Length = 822
Score = 179 bits (435), Expect = 2e-43
Identities = 104/253 (41%), Positives = 146/253 (57%), Gaps = 24/253 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW------KRGNIT-VAVKTLKDDTMA 287
+ L WE+ R +V+ LG G +G V A K +T VAVK LK D
Sbjct: 463 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 522
Query: 288 --LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA----GAR 340
L D + E +MK + +H N++ LLG CT++ P Y+I E+ S+GNL EYL+A G
Sbjct: 523 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 582
Query: 341 ECVP---------GAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADF 391
C + L+ A Q+A GM YL S+ IHRDLAARN LV E++++K+ADF
Sbjct: 583 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 642
Query: 392 GLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
GLAR + D Y + P+KW APE L ++ +SDVW+FG+LLWEI T G SPYP
Sbjct: 643 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 702
Query: 451 GVDLADVYHMLEK 463
GV + +++ +L++
Sbjct: 703 GVPVEELFKLLKE 715
>UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1;
Girardia tigrina|Rep: Tyrosine-protein kinase SPK-1 -
Dugesia tigrina (Planarian)
Length = 497
Score = 178 bits (434), Expect = 2e-43
Identities = 133/429 (31%), Positives = 212/429 (49%), Gaps = 24/429 (5%)
Query: 52 SANRWTSKENLLAHHEEDDPQ---LFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWC 108
S N+ TSK + + P + A Y + A G+ ++ ++ E + ++
Sbjct: 13 SKNKNTSKCQKIPKKAYEGPPGSYMVKAKYKYAASGDTDISFEEKEIMYVLEQFDEFWLK 72
Query: 109 EAHTLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEY-LLSSGIN-GSFLVRESESS 166
G VPSNYV+ + + I R AE L+ G+ G++++R S
Sbjct: 73 VVKQKDNKEGLVPSNYVSKQDGSPQSVEAWREIQRWEAEKSLMKIGLQKGTYIIRPSRKE 132
Query: 167 PGQRSISLR-YEGR-----VYHYRIN--EDADGKVYVTSESKFGTLAELVHHHSVAGDGL 218
++S+R ++ + V H++I +D G Y + F + L+ + G G
Sbjct: 133 -NSYALSVRDFDEKKKICIVKHFQIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGN 191
Query: 219 I-TQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVA 277
L P P +P P+ D EI+R +I + +++G G +G V+ A W R + VA
Sbjct: 192 THIPLTDPMPDNYQP---PVHFQDI-EINRENIEILNEIGRGFFGSVHRAKWGR-SYEVA 246
Query: 278 VKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCT--REPPFYIITEFMSRGNLLEYL 335
K L+ + F+ EA IM ++RH +V+LLGVCT ++ P II E+M G+L EYL
Sbjct: 247 AKMLQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL 306
Query: 336 RAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR 395
+ + +++M +I+ GM+YLES +HRDL A N LV + KVADFGL
Sbjct: 307 KTPDGKKT-NLNQMVHMMAEISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLTE 365
Query: 396 LMRDDTYTAHAGA-KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDL 454
L +FP KWTAPE F++KSDVW++GI+++EI T+ SPYP +
Sbjct: 366 LTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILTWASSPYPDIPA 425
Query: 455 ADVYHMLEK 463
+V + K
Sbjct: 426 KEVIEKVSK 434
>UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=103;
Euteleostomi|Rep: Ephrin type-A receptor 5 precursor -
Homo sapiens (Human)
Length = 1037
Score = 178 bits (434), Expect = 2e-43
Identities = 90/227 (39%), Positives = 139/227 (61%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI+ + I ++ +G G++G+V K + + VA+KTLK +DFL EASIM
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 728
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN++ L GV T+ P I+TE+M G+L +L+ + + L+ M I++
Sbjct: 729 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT--VIQLVGMLRGISA 786
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL ++HRDLAARN L+ N + KV+DFGL+R++ DD A+ G K PI+WTA
Sbjct: 787 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 846
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE +A+ F++ SDVW++GI++WE+ +YG PY + DV +E+
Sbjct: 847 PEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 893
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 178 bits (433), Expect = 3e-43
Identities = 93/227 (40%), Positives = 141/227 (62%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI+ + I ++ +G G++G+V + + +I VA+KTLK +DFL EASIM
Sbjct: 409 EIEASRIKIEKIIGSGEFGEVCYGRMRLPGKRDIPVALKTLKVGYTEKQKRDFLAEASIM 468
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV T P IITE+M G+L +LR + + L+ + IA+
Sbjct: 469 AQFDHPNVIRLEGVVTHSKPVMIITEYMENGSLDSFLRRHDGQFT--IIQLVGLLRGIAA 526
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAH--AGAKFPIKWTA 416
GM+YL +IHRDLAARN LV N + KV+DFGL+R++ DD A+ +G K PI+WTA
Sbjct: 527 GMTYLSDLGYIHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSGGKIPIRWTA 586
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE + + FS+ SDVW++G+++WE+ +YG PY + DV +E+
Sbjct: 587 PEAITFRKFSSSSDVWSYGVVMWEVTSYGERPYWNLTNRDVIKSVEE 633
>UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=17; Euteleostomi|Rep: BDNF/NT-3 growth
factors receptor precursor - Gallus gallus (Chicken)
Length = 818
Score = 178 bits (433), Expect = 3e-43
Identities = 94/222 (42%), Positives = 135/222 (60%), Gaps = 17/222 (7%)
Query: 245 IDRTDIVMKHKLGGGQYGDV-----YEAAWKRGNITVAVKTLKDDT-MALKDFLEEASIM 298
I R +IV+K +LG G +G V Y ++ I VAVKTLKD + A KDF EA ++
Sbjct: 529 IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELL 588
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV-------PGAVV--- 348
++H ++V+ GVC P ++ E+M G+L ++LRA + V P +
Sbjct: 589 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQ 648
Query: 349 LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAG 407
++++A QIA+GM YL S+ F+HRDLA RNCLVGEN LVK+ DFG++R + D Y
Sbjct: 649 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 708
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
PI+W PE + Y F+T+SDVW+ G++LWEI TYG P+
Sbjct: 709 TMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW 750
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 177 bits (432), Expect = 4e-43
Identities = 102/238 (42%), Positives = 141/238 (59%), Gaps = 18/238 (7%)
Query: 243 WEIDRTDI-VMKHKLGGGQYGDVYEAA----WKRGN-ITVAVKTLKDD--TMALKDFLEE 294
WE R + + KLG G +G VYE R N I VAVK ++DD + DF++E
Sbjct: 543 WEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDFVKE 602
Query: 295 ASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG-------- 345
IMK + RHPN++QLLG+CT++ P +I E GNL +++RA ++
Sbjct: 603 MEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIGNFT 662
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAH 405
+ +L + QIA GM+YL SRS +HRDL+ARN LVGE+ +K+ADFGL R++ D Y
Sbjct: 663 SSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIV-DYYYRKK 721
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
P+KW APE L ++TKSDVW++GILLWEI T G SPY + V ++ K
Sbjct: 722 TDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRK 779
>UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=73; Gnathostomata|Rep: BDNF/NT-3 growth
factors receptor precursor - Homo sapiens (Human)
Length = 822
Score = 177 bits (431), Expect = 5e-43
Identities = 94/222 (42%), Positives = 135/222 (60%), Gaps = 17/222 (7%)
Query: 245 IDRTDIVMKHKLGGGQYGDV-----YEAAWKRGNITVAVKTLKDDT-MALKDFLEEASIM 298
I R +IV+K +LG G +G V Y ++ I VAVKTLKD + A KDF EA ++
Sbjct: 533 IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELL 592
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV-------PGAVV--- 348
++H ++V+ GVC P ++ E+M G+L ++LRA + V P +
Sbjct: 593 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 652
Query: 349 LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAG 407
++++A QIA+GM YL S+ F+HRDLA RNCLVGEN LVK+ DFG++R + D Y
Sbjct: 653 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 712
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
PI+W PE + Y F+T+SDVW+ G++LWEI TYG P+
Sbjct: 713 TMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW 754
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 177 bits (431), Expect = 5e-43
Identities = 94/228 (41%), Positives = 131/228 (57%), Gaps = 15/228 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMALK--DFL 292
PD WE+ R I M +LG G +G VYE K VA+KT+ + + +FL
Sbjct: 989 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 1048
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARE-------CVPG 345
EAS+MKE ++V+LLGV ++ P +I E M+RG+L YLR+ E P
Sbjct: 1049 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 1108
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++ MA +IA GM+YL + F+HRDLAARNC+V E+ VK+ DFG+ R + D Y
Sbjct: 1109 LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRK 1168
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W +PE L F+T SDVW+FG++LWEIAT PY G+
Sbjct: 1169 GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGL 1216
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 177 bits (431), Expect = 5e-43
Identities = 96/231 (41%), Positives = 135/231 (58%), Gaps = 10/231 (4%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW----KRGNITVAVKTLKDDT--MALKDFLEEASIM 298
+ T++ LG G +G VY+ W + I VA+K L + T A +F++EA IM
Sbjct: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
M HP+LV+LLGVC P ++T+ M G LLEY+ G+ +L+ QIA
Sbjct: 773 ASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNI--GSQLLLNWCVQIAK 829
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-GAKFPIKWTAP 417
GM YLE R +HRDLAARN LV + VK+ DFGLARL+ D +A G K PIKW A
Sbjct: 830 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 889
Query: 418 EGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
E + Y F+ +SDVW++G+ +WE+ T+G PY G+ ++ +LEK + P
Sbjct: 890 ECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLP 940
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 177 bits (430), Expect = 7e-43
Identities = 94/226 (41%), Positives = 141/226 (62%), Gaps = 9/226 (3%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKD--DTMALKDFLEEASI 297
+E+ R I + LG GQ+GDV++ +K + I VAVKT K D + FLEEA I
Sbjct: 421 YELQRDQIQLGEILGEGQFGDVHKGTYKAKDGSLIPVAVKTCKREADLNTTEKFLEEAYI 480
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M++ H ++++L+GVC+ E P +I+ E G L YL+ ++ + A +L+Y A Q++
Sbjct: 481 MQKFDHQHIIKLIGVCS-ESPVWIVMELAKLGELRAYLQNN-KDDLDLATLLLY-AFQLS 537
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD-TYTAHAGAKFPIKWTA 416
+ +SYLES+ F+HRD+AARN LV + VK+ DFGL+R M DD +Y + K PIKW +
Sbjct: 538 TALSYLESKKFVHRDIAARNVLVSSHTSVKLGDFGLSRSMNDDQSYYKASKGKLPIKWMS 597
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE + + F+ SDVW FG+ +WEI YG+ P+ GV +V +E
Sbjct: 598 PESINFRRFTIASDVWMFGVCMWEILMYGIKPFQGVKNNEVLTKIE 643
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 177 bits (430), Expect = 7e-43
Identities = 106/245 (43%), Positives = 142/245 (57%), Gaps = 24/245 (9%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEA-------AWKRGNITVAVKTLKDDTMA--LKDFLE 293
WE R +V+ LG G +G V A + TVAVK LKD+ L D +
Sbjct: 457 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVS 516
Query: 294 EASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-----------GAR- 340
E +MK + RH N++ LLGVCT+E P Y+I E ++GNL E+LRA G R
Sbjct: 517 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 576
Query: 341 -ECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD 399
E L+ A Q+A GM YLESR IHRDLAARN LV E+ ++K+ADFGLAR +
Sbjct: 577 SEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHH 636
Query: 400 -DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
D Y + + P+KW APE L ++ +SDVW+F ILLWEI T G SPYPG+ + +++
Sbjct: 637 IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELF 696
Query: 459 HMLEK 463
+L +
Sbjct: 697 SLLRE 701
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 177 bits (430), Expect = 7e-43
Identities = 93/215 (43%), Positives = 136/215 (63%), Gaps = 12/215 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITVAVKTLKDDTMALK--DFLEEASI 297
EI + + + +G G++G+VY+ K + + VA+KTLK + DFL EA I
Sbjct: 607 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI 666
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + H N+++L GV ++ P IITE+M G L ++LR E + L+ M IA
Sbjct: 667 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEF--SVLQLVGMLRGIA 724
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD---TYTAHAGAKFPIKW 414
+GM YL + +++HRDLAARN LV N + KV+DFGL+R++ DD TYT +G K PI+W
Sbjct: 725 AGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTT-SGGKIPIRW 783
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
TAPE ++Y F++ SDVW+FGI++WE+ TYG PY
Sbjct: 784 TAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPY 818
>UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=18; Gnathostomata|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Gallus gallus (Chicken)
Length = 947
Score = 176 bits (429), Expect = 9e-43
Identities = 101/243 (41%), Positives = 142/243 (58%), Gaps = 27/243 (11%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMA--LKDFLEEAS 296
E R +I +G G +G V++A VAVK LK++ A DF EA+
Sbjct: 649 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 708
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR--------------AGAREC 342
+M E +PN+V+LLGVC P ++ E+M+ G+L EYLR AR C
Sbjct: 709 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRDRSPRNLCSLVQGGLEARAC 768
Query: 343 VPGAVVL-----MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM 397
+ + L + +A Q+A+GM+YL R F+HRDLA RNCLVGEN +VK+ADFGL+R M
Sbjct: 769 LLNPLALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNM 828
Query: 398 RD-DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLAD 456
D Y A+ PI+W PE + YN ++T+SDVWA+G++LWEI +YGM PY G+ +
Sbjct: 829 YSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEE 888
Query: 457 VYH 459
V +
Sbjct: 889 VIY 891
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 176 bits (428), Expect = 1e-42
Identities = 91/228 (39%), Positives = 137/228 (60%), Gaps = 8/228 (3%)
Query: 249 DIVMKHKLGGGQYGDVY--EAAWKRGN-ITVAVKTLKDDTMALK--DFLEEASIMKEMRH 303
D+ +LG G +G VY E K G I VAVK LK++ A DF E ++ +++H
Sbjct: 373 DVRFVEELGEGAFGKVYKGELTQKNGERIFVAVKALKENASAKTQADFKREIELISDLKH 432
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYM--ATQIASGMS 361
N+V +LGV +E P ++ E+M++G+L E+L A + L ++ A QI GM
Sbjct: 433 DNIVCILGVVLKEEPLCMLFEYMAQGDLHEFLIANSPNEGKSLSQLQFLLIAQQICDGME 492
Query: 362 YLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGL 420
YL S ++HRDLAARNCLVG+N VK++DFGL+R + D Y + + P++W E +
Sbjct: 493 YLASHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESI 552
Query: 421 AYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
Y F+T+SDVW+FG++LWEI +YG+ PY G +V +M+ + P
Sbjct: 553 LYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQLLP 600
>UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111;
Euteleostomi|Rep: Focal adhesion kinase 1 - Homo sapiens
(Human)
Length = 1052
Score = 176 bits (428), Expect = 1e-42
Identities = 92/231 (39%), Positives = 142/231 (61%), Gaps = 8/231 (3%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAW---KRGNITVAVKTLKDDTM--ALKDFLEEASI 297
+EI R I + +G GQ+GDV++ + + + VA+KT K+ T + FL+EA
Sbjct: 415 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 474
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M++ HP++V+L+GV T E P +II E + G L +L+ + + A +++Y A Q++
Sbjct: 475 MRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQV-RKYSLDLASLILY-AYQLS 531
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAP 417
+ ++YLES+ F+HRD+AARN LV N VK+ DFGL+R M D TY + K PIKW AP
Sbjct: 532 TALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 591
Query: 418 EGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
E + + F++ SDVW FG+ +WEI +G+ P+ GV DV +E + P
Sbjct: 592 ESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP 642
>UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=51;
Euteleostomi|Rep: Ephrin type-A receptor 7 precursor -
Homo sapiens (Human)
Length = 998
Score = 176 bits (428), Expect = 1e-42
Identities = 93/227 (40%), Positives = 136/227 (59%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
E+D + I ++ +G G++G+V K + ++ VA+KTLK +DFL EASIM
Sbjct: 627 ELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIM 686
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+V L GV TR P I+ EFM G L +LR + + L+ M IA+
Sbjct: 687 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFT--VIQLVGMLRGIAA 744
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL ++HRDLAARN LV N + KV+DFGL+R++ DD + G K P++WTA
Sbjct: 745 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTA 804
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE + Y F++ SDVW++GI++WE+ +YG PY + DV +E+
Sbjct: 805 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEE 851
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 175 bits (427), Expect = 2e-42
Identities = 95/240 (39%), Positives = 141/240 (58%), Gaps = 19/240 (7%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEA-----AWKRGNITVAVKTLKD--DTMALKDFLEEA 295
WE RT++++ LG G++G V + K G TVAVK LK +++ L L E
Sbjct: 480 WEFPRTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTGANSVELLALLSEY 539
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR---------AGARECVPGA 346
+++E+ HPN+++LLG CT+ +I E+ G+L YLR A V
Sbjct: 540 QLLQEVNHPNVIRLLGACTKGDSPLLIIEYCQYGSLKNYLRLSRKLEVLNADYENAVEPI 599
Query: 347 VV--LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYT 403
V ++ A QI+ GM+YL +HRDLAARN L+ E + K++DFGL R + DD Y
Sbjct: 600 TVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYEDDAYL 659
Query: 404 AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ + P+KW APE LA + ++TKSDVWAFG+L WE+ T G SPYPG+ ++Y++L++
Sbjct: 660 KKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNLYNLLKQ 719
>UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n=4;
Caenorhabditis|Rep: Protein kinase protein 32, isoform a
- Caenorhabditis elegans
Length = 867
Score = 175 bits (426), Expect = 2e-42
Identities = 93/221 (42%), Positives = 135/221 (61%), Gaps = 11/221 (4%)
Query: 250 IVMKHKLGGGQYGDVYEAAW----KRGNITVAVKTLKDDTMALKD--FLEEASIMKEMRH 303
I +K +GGGQ+G+VY+A + K I VAVK K D L+E+S+M+ RH
Sbjct: 367 ITLKELIGGGQFGNVYKAVYHDLEKDERIAVAVKVCKTDAEPADTQLILQESSLMRNFRH 426
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
N++QL+GVC + P +++ E +G L EYL+ ++ +P ++ ++ +QI + YL
Sbjct: 427 SNIIQLIGVCV-DQPMWLVLELAPKGELREYLQQ-EKDWLPLRILTLF-CSQICDSLVYL 483
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR-DDTYTAHAGAKFPIKWTAPEGLAY 422
S F+HRD+AARN LV VK+ADFGL+R + D YTA G K PIKW APE + Y
Sbjct: 484 HSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDAVYTASRG-KLPIKWLAPESVNY 542
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
FS SDVW FG+ +WEI + G+ P+ GV +DV +E+
Sbjct: 543 RQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQ 583
>UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga
brevicollis|Rep: Receptor tyrosine kinase - Monosiga
brevicollis
Length = 1476
Score = 175 bits (426), Expect = 2e-42
Identities = 100/253 (39%), Positives = 145/253 (57%), Gaps = 14/253 (5%)
Query: 222 LLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT-----V 276
++ PA + + D WE+DR + + +LG G +G+V++A W R + +
Sbjct: 698 VVMPAAFEGSYDLLEVQDADVWEVDRQCVRLGEELGHGAFGEVFQA-WIRNSYSGKVRRC 756
Query: 277 AVKTLKDDTMA--LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLE 333
A KTLK D +DFL E ++MKE+ HPN++ ++G C RE P ++ E GN+ +
Sbjct: 757 AAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRD 816
Query: 334 YLRA-GARECVPGAVVLMYMAT---QIASGMSYLESRSFIHRDLAARNCLVGENHLVKVA 389
YLR A + P + + MA QIA GM++LE ++ IHRDLAARN LV +N K++
Sbjct: 817 YLRGCRATQENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKIS 876
Query: 390 DFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
DFGLAR + Y A K P+KW APE L ++TKSDVW+FG+ +WEI + G +PY
Sbjct: 877 DFGLARSIEGGEYKTTA-TKLPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPY 935
Query: 450 PGVDLADVYHMLE 462
DV LE
Sbjct: 936 KEHQNRDVLSFLE 948
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 175 bits (426), Expect = 2e-42
Identities = 99/232 (42%), Positives = 139/232 (59%), Gaps = 15/232 (6%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT---VAVKTLKDDTMA---LKDFLEEASIM 298
IDR +++ LG G++G V E K+ + T VAVKT+K D + +++FL EA+ M
Sbjct: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACM 641
Query: 299 KEMRHPNLVQLLGVCTRE-----PPFYIITEFMSRGNLLEYLRAGARECVPGAV---VLM 350
K+ HPN+++LLGVC P +I FM G+L YL E P + L+
Sbjct: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
Query: 351 YMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAK 409
IA GM YL +R+F+HRDLAARNC++ ++ V VADFGL++ + D Y AK
Sbjct: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
Query: 410 FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
P+KW A E LA +++KSDVWAFG+ +WEI T GM+PYPGV ++Y L
Sbjct: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYL 813
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 175 bits (426), Expect = 2e-42
Identities = 96/215 (44%), Positives = 129/215 (60%), Gaps = 10/215 (4%)
Query: 255 KLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMAL--KDFLEEASIMKEMRHPNLVQL 309
+LG G++G V + W I VA+KTL D M K+FL EA +M ++ HP +V L
Sbjct: 489 ELGVGEFGSVIKGIWLSPGGKEINVAMKTLHKDKMVQGEKEFLREALVMSQLNHPCIVSL 548
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
LGVC PP ++ E + G LL+YL E V L A+QIA GM YLE + F+
Sbjct: 549 LGVCLG-PPMILVQELVEMGALLDYLMDYQPEIQE--VDLKLWASQIAFGMMYLELKRFV 605
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAHAGAKFPIKWTAPEGLAYNTFST 427
HRDLAARN L+ VK++DFGL+R + D Y A G ++P++W APE + Y TFST
Sbjct: 606 HRDLAARNILLANKKQVKISDFGLSRAVGTGSDYYQAKQGGRWPVRWYAPESINYGTFST 665
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
KSDVW++GI LWE+ T+G PY + +V LE
Sbjct: 666 KSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFLE 700
Score = 65.7 bits (153), Expect = 2e-09
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 136 WYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
W H + RN A +L +S +GSFL+R S G ++L YE + YH++I AD
Sbjct: 287 WLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKTYHFQIKSRADRWF 346
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYPAP 227
Y+ F TL LV H+ DGL T L +P P
Sbjct: 347 YIDDGPLFETLPHLVDHYMQYADGLPTLLQFPVP 380
Score = 55.2 bits (127), Expect = 4e-06
Identities = 28/90 (31%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 136 WYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
WYHG I+R A +L G +G FL+R+ ++P +S+ + ++ H++IN D K
Sbjct: 10 WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRSQILHFQINCLGDNKF 69
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLL 223
+ + F L L+ ++ V DGL +L+
Sbjct: 70 SIDNGPIFQGLDMLISYYKVISDGLPCKLV 99
>UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2;
Anthomedusae|Rep: Protein-tyrosine kinase - Hydractinia
echinata (Snail fur) (Hermit crab hydroid)
Length = 1162
Score = 175 bits (425), Expect = 3e-42
Identities = 96/245 (39%), Positives = 146/245 (59%), Gaps = 16/245 (6%)
Query: 236 PLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRG----NITVAVKTLK-------DD 284
P++ D+ E+ R D+ + +G GQ+GDVY+ +K I VAVKT K +D
Sbjct: 416 PMSAKDY-EVARDDLTLDEIIGQGQFGDVYQGTFKSKISSVEIPVAVKTYKIELDKEQED 474
Query: 285 TMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVP 344
+ FLEEA +M++ HP++++L+G+ + + P YII E S G L YL+ R
Sbjct: 475 GTRAEKFLEEAYLMQQFDHPHVIKLIGIVS-DSPSYIIMELASYGELRSYLQQ-YRTQTE 532
Query: 345 GAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD-TYT 403
+L Y+ Q+++ +SYLESR+F+HRD+AARN L + H +K+ADFGL+R + ++ +Y
Sbjct: 533 SERLLTYIY-QLSTALSYLESRNFVHRDIAARNILAADPHTIKLADFGLSRWIDEEQSYY 591
Query: 404 AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ K PIKW APE + + FS+ SDVW FG+ WEI YG+ P+ GV V +E
Sbjct: 592 KASKGKLPIKWMAPESINFRRFSSASDVWMFGVCCWEILMYGVKPFQGVPNEKVIGKIEN 651
Query: 464 VKFAP 468
+ P
Sbjct: 652 GERLP 656
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 174 bits (424), Expect = 4e-42
Identities = 92/229 (40%), Positives = 141/229 (61%), Gaps = 9/229 (3%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMAL--KDFLEEASIMK 299
I D+ + +LG G++G V + +K + I VAVKTL+ D+ K+F EA IM
Sbjct: 460 ISEHDLHLGAELGQGEFGSVLKGLYKGADGKKIEVAVKTLRLDSQGHGEKEFAREAGIMV 519
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASG 359
+ HP +V+L+G+ T P ++ E +S G L++YL ++ +P + L A +IASG
Sbjct: 520 TLNHPCIVKLIGI-TNGKPMMMVQELISMGALVDYLYE-RKQPIPDVLTLKLWAAEIASG 577
Query: 360 MSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAP 417
M YLE++ F+HRDLAARN LV VK++DFGL+R + D Y A G ++P+KW AP
Sbjct: 578 MMYLETKRFVHRDLAARNILVQSMKQVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAP 637
Query: 418 EGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKF 466
E + + TFS SDVW++GI LWE+ ++G +PY + A+V +E + +
Sbjct: 638 ESINFGTFSHASDVWSYGITLWEMFSFGDAPYGDMTGAEVLDRVENLNY 686
Score = 72.9 bits (171), Expect = 2e-11
Identities = 41/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 119 WVPSNYVTPVNSLEKHSWYHGPISRN-AAEYLLSSGIN-GSFLVRESESSPGQRSISLRY 176
W + Y P + + + H I RN A E L G++ GSFL+R + PG +++L Y
Sbjct: 277 WATACYPKP--RMNTNDFLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVY 334
Query: 177 EGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFP 236
+ YHY + ++D ++ F TL +V H+++ DGL T LLYP P + V
Sbjct: 335 KQTPYHYEVVCESDCWYFIDDGPLFDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVPF 394
Query: 237 LAPP 240
+PP
Sbjct: 395 SSPP 398
Score = 65.3 bits (152), Expect = 3e-09
Identities = 37/97 (38%), Positives = 52/97 (53%), Gaps = 4/97 (4%)
Query: 130 SLEKHSWYHGPISRNAAEYLLSSGI----NGSFLVRESESSPGQRSISLRYEGRVYHYRI 185
S + WYHG I+R A +L+S G G FLVRES +PG ++L +G V ++I
Sbjct: 4 SADAERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQI 63
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQL 222
+G V + F L EL+HH+ + DGL QL
Sbjct: 64 MGHGEGWFSVDNGPLFQGLDELIHHYQLKPDGLPVQL 100
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor -
Aplysia californica (California sea hare)
Length = 1145
Score = 174 bits (424), Expect = 4e-42
Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 27/269 (10%)
Query: 220 TQLLYPAPKRSKPT-VFPLAPPDHW---EIDRTDIVMKHKLGGGQYGDVYEAA----WKR 271
T+ P K+++P + PL P E +I +LG G +G VY+ +
Sbjct: 537 TRASRPNNKQAQPVEMSPLNPKSASRAREFPMPNIRFLQELGEGAFGKVYKGELVGLYGE 596
Query: 272 GNIT-VAVKTLKDDTM--ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSR 328
++T VA+KTLK++ + DF E +M +MRHPN+V LLGVC ++ P ++ E+M++
Sbjct: 597 SSVTTVAIKTLKENALPKVQNDFRREVDLMSDMRHPNIVCLLGVCMKQEPMCMLFEYMAQ 656
Query: 329 GNLLEYLRAGAREC----------VPGAVVLMY-----MATQIASGMSYLESRSFIHRDL 373
G+L EYL + + G +L Y ++TQ+A+GM YL S F+HRDL
Sbjct: 657 GDLHEYLLSHSPHSDVTAAEDDSGTGGGHILEYSEMLHVSTQVAAGMEYLASHHFVHRDL 716
Query: 374 AARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVW 432
AARN LV + VK++DFGL+R + D Y + + P++W PE + Y F+T SDVW
Sbjct: 717 AARNILVADGLTVKISDFGLSRDVYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTDSDVW 776
Query: 433 AFGILLWEIATYGMSPYPGVDLADVYHML 461
AFG++LWE+ +YG+ PY G +V M+
Sbjct: 777 AFGVVLWEVFSYGLQPYYGFSNQEVIEMI 805
>UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep:
MBRTK2 - Monosiga brevicollis
Length = 759
Score = 174 bits (424), Expect = 4e-42
Identities = 94/248 (37%), Positives = 141/248 (56%), Gaps = 12/248 (4%)
Query: 225 PAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNI----TVAVKT 280
PA F + D WE++R + + KLG G +G V+ A + + + A K
Sbjct: 335 PATSEDLYAFFDVRDADIWEVERRSVRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKA 394
Query: 281 LKDDT--MALKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR- 336
LK A +DFL E ++MKE+ HPN++ + G C R+ P ++ E GNL +YLR
Sbjct: 395 LKPGAPFRARQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRK 454
Query: 337 ---AGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGL 393
+ ++ + G+ L QIASGMS+LE ++ IHRDLAARN L+ ++ K+ DFGL
Sbjct: 455 CRTSQSKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGL 514
Query: 394 ARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVD 453
AR + ++ Y A K P+KW APE L Y +++KSDVW+FG+ +WEI + G +PY
Sbjct: 515 ARSIENEDYETTA-TKLPVKWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVKHR 573
Query: 454 LADVYHML 461
D+ +L
Sbjct: 574 NVDILSLL 581
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 174 bits (424), Expect = 4e-42
Identities = 97/244 (39%), Positives = 142/244 (58%), Gaps = 17/244 (6%)
Query: 237 LAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMA--LK 289
+AP WEI + LG G +G V+ A + G TVAVK LK+D LK
Sbjct: 461 IAPDPAWEIKLEQLETDCLLGEGAFGRVFRATARDLPNHTGVQTVAVKMLKEDCCEQDLK 520
Query: 290 DFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV 348
DF+ E +MK + +H N++ LL V +++ YI+ E+ GNL +L+ +V+
Sbjct: 521 DFISEIEVMKSIGKHINILNLLAVSSQQGKLYIVVEYCRHGNLRSFLKDNRPVMQANSVI 580
Query: 349 L----MYMAT----QIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRD 399
+Y T Q+A GM++L S+ IHRD+AARN LVGE +L+K+ADFGLAR +
Sbjct: 581 TKKITLYDLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLARDIHEQ 640
Query: 400 DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
D Y + P+KW A E L ++T+SD+W+FGIL WEI T+G SPYPG+ L ++
Sbjct: 641 DYYRKCTDGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIALEKLFD 700
Query: 460 MLEK 463
+L++
Sbjct: 701 LLKQ 704
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 174 bits (423), Expect = 5e-42
Identities = 84/169 (49%), Positives = 115/169 (68%), Gaps = 4/169 (2%)
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMS-RGNLLEYLRAGARECVPGAVVLMYMATQ 355
I+K+ HPN+V+L+GVCT++ P YI+ E + G+ L +LR R+ P A+V M A
Sbjct: 710 ILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSGDFLTFLRNQGRDLKPKALVKM--AEN 767
Query: 356 IASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK-FPIKW 414
+ASGM+YLES+ IHRDLAARNCLV EN+ VK++DFG++R D Y A G + PIKW
Sbjct: 768 VASGMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQDDDGVYLAEGGLRQIPIKW 827
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TAPE L Y ++T+SDVW+FGILLWE + G++PY + +EK
Sbjct: 828 TAPEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEVEK 876
Score = 76.2 bits (179), Expect = 2e-12
Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 13/154 (8%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDAD 190
LE+ +WYHG I R + LL+ +G FLVR+S+ PG +S+ + G H+ + ++ D
Sbjct: 523 LEQQTWYHGAIPRLEVQQLLTK--DGDFLVRKSQEKPGY-VLSVHWSGACKHFLV-QNKD 578
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDI 250
+ ES F T+ +L+ + + + K+S+ + D W ++ DI
Sbjct: 579 NMYCLDGES-FHTIPQLIQQYQTSQQHVT--------KKSEVVLRRPVLKDKWVLEHDDI 629
Query: 251 VMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDD 284
++ H +G G +G+VY+ + N VAVKT K++
Sbjct: 630 ILGHIIGRGNFGEVYKGQLRPDNTPVAVKTCKNN 663
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 174 bits (423), Expect = 5e-42
Identities = 93/226 (41%), Positives = 133/226 (58%), Gaps = 15/226 (6%)
Query: 247 RTDIVMKHKLGGGQYGDVYEAAWK------RGNITVAVKTLKDDTMA--LKDFLEEASIM 298
R ++ +++ + G++G+V++ G I VAVKTL+ + K FL EA++M
Sbjct: 1699 RGNLKLENFIDRGEFGEVFQGTATDILGPGTGPIPVAVKTLRKGAIIEEQKKFLAEAALM 1758
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV---LMYMATQ 355
HPN+V++LGVC P YII E M G+LL +LR E P + L+ +A
Sbjct: 1759 GNFNHPNIVKVLGVCVENDPVYIIMELMPGGDLLHFLRDAKVERGPPLLTVKELIQIALD 1818
Query: 356 IASGMSYLESRSFIHRDLAARNCLV---GENHLVKVADFGLAR-LMRDDTYTAHAGAKFP 411
+A G YL+ FIHRDLAARNCLV G + +VK+ DFGLA+ L D Y K P
Sbjct: 1819 VAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDFGLAKDLYSSDYYQVEGQRKLP 1878
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
++W APE L F+ +SDVW+FG+L+WEI T+G PYP ++ +V
Sbjct: 1879 VRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYPALNNQEV 1924
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 173 bits (422), Expect = 6e-42
Identities = 99/233 (42%), Positives = 144/233 (61%), Gaps = 17/233 (7%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT---VAVKTLKDDTMA---LKDFLEEASIM 298
++R + + LG G++G V E + + T VAVKT+K D + +++FL EA+ M
Sbjct: 466 VERNLLNLGKVLGEGEFGSVMEGELQYSDGTNHKVAVKTMKMDNFSQREIEEFLSEAACM 525
Query: 299 KEMRHPNLVQLLGVCT-----REPPFYIITEFMSRGNLLEYL---RAGAR-ECVPGAVVL 349
K+ HPN+++LLGVC R P +I FM G+L +L R G+ + VP ++
Sbjct: 526 KDFNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIGSGPQHVPLRTLV 585
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGA 408
+M IA+GM YL SR+F+HRDLAARNC++ ++ V VADFGL++ + D Y A
Sbjct: 586 KFMI-DIATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIA 644
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
K P+KW A E LA ++ KSDVWAFG+ +WEI+T GM+PYPGV ++Y L
Sbjct: 645 KMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYL 697
>UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase
erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4).; n=1; Takifugu
rubripes|Rep: Receptor tyrosine-protein kinase erbB-4
precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4). - Takifugu
rubripes
Length = 1236
Score = 173 bits (422), Expect = 6e-42
Identities = 95/232 (40%), Positives = 135/232 (58%), Gaps = 12/232 (5%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW----KRGNITVAVKTLKDDT--MALKDFLEEASIM 298
+ T++ LG G +G VY+ W ++ I VAVK L + T A +F++EA IM
Sbjct: 665 LKETELKRVKVLGSGAFGTVYKGIWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIM 724
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
M HP+LV+LLGVC P ++T+ M G LL+Y+ G+ +L+ QIA
Sbjct: 725 ASMEHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLDYVHEHKDNI--GSQLLLNWCVQIAK 781
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTA 416
GM YLE R +HRDLAARN LV + +K+ DFGLARL+ + Y A G K IKW A
Sbjct: 782 GMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDVNEKEYNADGG-KMAIKWMA 840
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
E + Y F+ +SDVW++G+ +WE+ T+G PY G+ D+ +LEK + P
Sbjct: 841 LECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLP 892
>UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 712
Score = 173 bits (422), Expect = 6e-42
Identities = 96/214 (44%), Positives = 129/214 (60%), Gaps = 11/214 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI + I + +G G++G+VY K R VA+KTLK +DFL EASIM
Sbjct: 346 EIHPSHIAKEKVIGAGEFGEVYRGILKVPGRKESAVAIKTLKPGYTEKQRQDFLSEASIM 405
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ H N+++L GV T+ IITE+M G L YLR E + L+ M IA+
Sbjct: 406 GQFAHQNIIRLEGVVTKFKHAMIITEYMENGALDRYLRDHDGEFT--SFQLVGMLRGIAA 463
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD---TYTAHAGAKFPIKWT 415
GM YL S++HRDLAARN LV KV+DFGL+R++ DD TYT +G K PI+WT
Sbjct: 464 GMKYLSDMSYVHRDLAARNILVNNTLECKVSDFGLSRVLEDDPEGTYTT-SGGKIPIRWT 522
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
APE +AY F++ SDVW+FGI++WE+ +G PY
Sbjct: 523 APEAIAYRKFASASDVWSFGIVMWEVMAFGERPY 556
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 173 bits (422), Expect = 6e-42
Identities = 98/227 (43%), Positives = 137/227 (60%), Gaps = 13/227 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKD--DTMALKDFLEEASIMKEM 301
EID + ++ +G G++G+V + + N VA+KTLK +T DFL EASIM +
Sbjct: 640 EIDFKLVNIEQVIGRGEFGEVCKGTFF--NKCVAIKTLKVGYNTQERSDFLGEASIMGQF 697
Query: 302 RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMS 361
HPN+++L GV T+ P IITEFM G+L +LR +P A L M IA GM
Sbjct: 698 DHPNVIRLEGVVTKSRPLMIITEFMENGSLDAFLR-NQEGKIPSA-QLTEMLLSIAQGME 755
Query: 362 YLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM----RDDT--YTAHAGAKFPIKWT 415
YL + ++HRDLAARN LV N + KV+DFGL+R++ DD YT G PI+WT
Sbjct: 756 YLSNMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEQLEEDDVAMYTTR-GGMIPIRWT 814
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
+PE + TFST SDVW+FGI++WE+ ++G PY + DV ++
Sbjct: 815 SPEAITMRTFSTSSDVWSFGIVMWEVMSFGERPYWEMSNQDVVQFVD 861
>UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1002
Score = 173 bits (422), Expect = 6e-42
Identities = 96/226 (42%), Positives = 135/226 (59%), Gaps = 10/226 (4%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT--VAVKTLKDDTMALK--DFLEEASIMK 299
EID+T I + +G G++G+V G T VAVK LK + +FL EA M
Sbjct: 609 EIDQTRIKIDSVIGRGEFGEVCRGKMLTGKTTTSVAVKRLKHGASLIDHTNFLREACTMA 668
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASG 359
+ + PN++QL GV T+ P IITEFM G+L ++L+A R P + L+ M IASG
Sbjct: 669 QFKDPNIIQLKGVVTKSIPAMIITEFMEHGSLDKFLQA--RSGQPTVLQLLEMLRGIASG 726
Query: 360 MSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDD---TYTAHAGAKFPIKWTA 416
M YL S ++HRDLAARN LV + KV+DFGL+R + +D TYT G K ++WTA
Sbjct: 727 MKYLSSMKYVHRDLAARNILVNSQLVCKVSDFGLSRTLENDPQATYTTQ-GGKIALRWTA 785
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE + F++ SDVW++GI++WE+ +YG PY + V +LE
Sbjct: 786 PESIRCRQFTSASDVWSYGIVMWEVMSYGEKPYWDMSNEVVTEVLE 831
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 172 bits (419), Expect = 1e-41
Identities = 100/245 (40%), Positives = 146/245 (59%), Gaps = 24/245 (9%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVY--EAAW----KRGNIT-VAVKTLKDDTMALK--DFLE 293
WE+ R + + LG G +G V EA K +T VAVK LK D D +
Sbjct: 341 WELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTKVAVKMLKADATEKDRADLIS 400
Query: 294 EASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA----------GAREC 342
E +MK + +H N++ LLG CT++ P Y++ E+ S+GNL +YLRA +R
Sbjct: 401 EMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRPAGLEYWSSSRPV 460
Query: 343 VPGAVVLMYM---ATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD 399
++ +M + A Q+A GM+YL S+ IHRDLAARN LV E++++K+ADFGLAR +
Sbjct: 461 SLASMEIMELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHH 520
Query: 400 -DTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
D Y + P+KW APE L ++ +SDVW+FG+LLWEI T G SPYPGV + +++
Sbjct: 521 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 580
Query: 459 HMLEK 463
+L++
Sbjct: 581 KLLKE 585
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 172 bits (419), Expect = 1e-41
Identities = 88/216 (40%), Positives = 137/216 (63%), Gaps = 11/216 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMA--LKDFLEEASIM 298
E+D + ++H+LG G +G V + + N + VAVKTLK++ + + ++EA IM
Sbjct: 351 ELDPKRLRLEHELGHGNFGSVVKGVYLLKNNKSVAVAVKTLKEEDIPGQKSEIVKEAEIM 410
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
++ HPN+V+L+GV T+ P F ++ E +G L ++L+ V +VLM Q+
Sbjct: 411 SKLDHPNIVRLIGV-TQSPGFMLVMELAPQGPLHKFLKKNRNMNVLDILVLML---QVDE 466
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAHAGAKFPIKWTA 416
GM+YLES+ F+HRDLAARN LV + VK++DFG++R M ++ Y A K+P+KW A
Sbjct: 467 GMNYLESQHFVHRDLAARNVLVVSENFVKISDFGMSRAMGVGNEYYRAERAGKWPLKWYA 526
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
PE + Y+ FS+K DVW++GI +WE +YG PY G+
Sbjct: 527 PECIYYHKFSSKGDVWSYGITMWEAVSYGGKPYQGM 562
Score = 65.7 bits (153), Expect = 2e-09
Identities = 35/96 (36%), Positives = 54/96 (56%), Gaps = 3/96 (3%)
Query: 136 WYHGPISRNAAEYLL---SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGK 192
W+HG I+R+ AE L +S +G++L+RES S G +S+ + +V HY I G
Sbjct: 9 WFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDKKVIHYAIQRQPSGM 68
Query: 193 VYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPK 228
V + +F ELV+HH + GL+T+L YP +
Sbjct: 69 VGIADGPQFPGPVELVNHHKTSLGGLMTKLTYPCER 104
Score = 60.1 bits (139), Expect = 1e-07
Identities = 33/88 (37%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 136 WYHGPISRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVY 194
W+HG I R AE L S G FL+RE S G I L Y+G VYHY + G++
Sbjct: 161 WFHGVIPRTEAERRLKSLSETGMFLIRERGSPRGSYVIGLFYQGGVYHYLFESNNQGQLS 220
Query: 195 VTSESKFGTLAELVHHHSVAGDGLITQL 222
+ S F L +V+ +S +GL L
Sbjct: 221 IKSGRSFDNLMAVVNFYSQKSEGLFCTL 248
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 172 bits (418), Expect = 2e-41
Identities = 94/226 (41%), Positives = 130/226 (57%), Gaps = 15/226 (6%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMALK--DFLE 293
D WE+ R I M LG G +G VYE K + + AVKT+ D + +FL
Sbjct: 321 DEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRERIEFLN 380
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV------PGAV 347
EAS+MK ++V+LLGV TR P +I E M G+L YLR+ R C P
Sbjct: 381 EASVMKGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYLRSH-RPCENMSNAPPKLD 439
Query: 348 VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHA 406
++ MA +IA GM+YL ++ F+HRDLAARNC+V E+ VKV DFG+ R + D Y +
Sbjct: 440 RILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMTRDIYERDYYRKGS 499
Query: 407 GAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W APE L FS+ SDVW++G++LWE+ T+ PY G+
Sbjct: 500 KGLLPVRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGL 545
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 171 bits (417), Expect = 3e-41
Identities = 97/230 (42%), Positives = 135/230 (58%), Gaps = 16/230 (6%)
Query: 250 IVMKHKLGGGQYGDVYEAAWKRGNIT---VAVKTLKDDTMALKDF---LEEASIMKEMRH 303
+ + LG G++G V EA K N + VAVK LK D + D L+EA+ MK+ H
Sbjct: 497 LTLGRMLGKGEFGSVREAFLKSENNSGQKVAVKVLKTDINSSSDIEQCLKEAAYMKDFHH 556
Query: 304 PNLVQLLGVCT------REPPFYIITEFMSRGNLLEYL---RAGARECVPGAVVLMYMAT 354
PN++QL+GV R P +I FM G+L +L R G +L+
Sbjct: 557 PNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSRLGDEPFTVSQQILIQFML 616
Query: 355 QIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIK 413
IA GM YL +++ IHRDLAARNC++ EN V VADFGL++ + D Y + +K P+K
Sbjct: 617 DIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSVSKLPVK 676
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
W A E LA N ++T+SDVWAFG+ +WEI T G +PYPGV+ +++Y L K
Sbjct: 677 WIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIYEYLIK 726
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 171 bits (417), Expect = 3e-41
Identities = 116/306 (37%), Positives = 157/306 (51%), Gaps = 34/306 (11%)
Query: 180 VYHYRINEDADGKVYVT---SESKFGTLAELVHHHSVAGDGLITQL--LYPAPKRSKPTV 234
V+H R+ K VT +E K LAEL AG GL ++ P + +
Sbjct: 1881 VWHRRLKNQKSAKEGVTVLINEDK--ELAEL--RGLAAGVGLANACYAIHTLPTQEEIEN 1936
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK------RGNITVAVKTLKDDTMAL 288
P P R + ++ LG G +G+VYE G I VAVKTLK +
Sbjct: 1937 LPAFP-------REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ 1989
Query: 289 K--DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGA 346
+ +FL+EA +M + HPN+++ LGVC P YII E M G+LL YLR G
Sbjct: 1990 EKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP 2049
Query: 347 VV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGEN-----HLVKVADFGLAR-L 396
++ L+ + I+ G YLE FIHRDLAARNCLV +VK+ DFGLAR +
Sbjct: 2050 LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI 2109
Query: 397 MRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLAD 456
++D Y P++W APE L F+T+SDVW+FGIL+WEI T G PYP D
Sbjct: 2110 YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLD 2169
Query: 457 VYHMLE 462
V + ++
Sbjct: 2170 VLNYVQ 2175
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 171 bits (416), Expect = 3e-41
Identities = 89/215 (41%), Positives = 127/215 (59%), Gaps = 11/215 (5%)
Query: 256 LGGGQYGDVYEAAW---KRGNITVAVKTLK--DDTMALKDFLEEASIMKEMRHPNLVQLL 310
+G G +G VY + + + AVK+L D +++FL E +MK HPN++ L+
Sbjct: 1063 IGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDLEEVEEFLREGILMKSFHHPNVLSLI 1122
Query: 311 GVC-TREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
G+C +E ++ FM G+L ++R+ R P L+ Q++ GM YL +R F+
Sbjct: 1123 GICLPQEGLPLVVLPFMKHGDLRHFIRSEERN--PTVKDLVGFGLQVSRGMEYLANRKFV 1180
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNTFS 426
HRDLAARNC++ E+ VKVADFGLAR + D Y + H A+ P+KW A E L F+
Sbjct: 1181 HRDLAARNCMLDESFHVKVADFGLARDVFDKEYYSVRRHKNARLPVKWMAMESLQTQKFT 1240
Query: 427 TKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
TKSDVW+FG+LLWE+ T G PYP VD D+ L
Sbjct: 1241 TKSDVWSFGVLLWELMTRGAPPYPDVDAYDITRYL 1275
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 171 bits (416), Expect = 3e-41
Identities = 96/226 (42%), Positives = 127/226 (56%), Gaps = 20/226 (8%)
Query: 254 HKL-GGGQYGDVYEA------AWKRGNITVAVKTLKDDT--MALKDFLEEASIMKEMRHP 304
HKL G G +G+VYE A G VAVKTLK +FL+EA +M + HP
Sbjct: 101 HKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHP 160
Query: 305 NLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV----LMYMATQIASGM 360
++++LLGVC P Y+I E M G+LL YLR ++ ++ L+ + I G
Sbjct: 161 HILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGC 220
Query: 361 SYLESRSFIHRDLAARNCLVGE------NHLVKVADFGLAR-LMRDDTYTAHAGAKFPIK 413
YLE FIHRDLAARNCLV E + +VK+ DFGLAR + ++D Y P++
Sbjct: 221 VYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVR 280
Query: 414 WTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
W APE L F+ SDVWAFG+L+WE T G PYPG+ +V H
Sbjct: 281 WMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIEVLH 326
>UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep:
MBTK3 - Monosiga brevicollis
Length = 357
Score = 171 bits (415), Expect = 4e-41
Identities = 97/230 (42%), Positives = 137/230 (59%), Gaps = 8/230 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMA--LKDFLEEASIMKEM 301
++ R+D++ +G GQ+G VY A +K GN VAVKT++ A + +F E+ +M +
Sbjct: 71 QLHRSDLIAGKPIGAGQFGQVYLAKYK-GN-QVAVKTVRQGASAEDIAEFTAESEVMLAL 128
Query: 302 RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV-LMYMATQIASGM 360
RH LVQLLGV ++ P+ + EFM G+L E L+ + + A + + A QI+ GM
Sbjct: 129 RHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLRLAYLEQLAFAVQISRGM 188
Query: 361 SYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD--DTYTAHAGAKFPIKWTAPE 418
+++ + ++H DLAARN L+ E + KVADFGL R DTYT AK PI+W A E
Sbjct: 189 AFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIE 248
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV-YHMLEKVKFA 467
+ FS KSDVWAFG+ L EIA YG PY GV DV H+L+ + A
Sbjct: 249 AMKTKVFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGNRLA 298
>UniRef50_P04629 Cluster: High affinity nerve growth factor receptor
precursor; n=28; Eumetazoa|Rep: High affinity nerve
growth factor receptor precursor - Homo sapiens (Human)
Length = 796
Score = 171 bits (415), Expect = 4e-41
Identities = 90/224 (40%), Positives = 134/224 (59%), Gaps = 19/224 (8%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW-----KRGNITVAVKTLKDDT-MALKDFLEEASIM 298
I R DIV+K +LG G +G V+ A ++ + VAVK LK+ + A +DF EA ++
Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELL 564
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR---------AGARECVPGAV-- 347
++H ++V+ GVCT P ++ E+M G+L +LR AG + PG +
Sbjct: 565 TMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL 624
Query: 348 -VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAH 405
L+ +A+Q+A+GM YL F+HRDLA RNCLVG+ +VK+ DFG++R + D Y
Sbjct: 625 GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG 684
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
PI+W PE + Y F+T+SDVW+FG++LWEI TYG P+
Sbjct: 685 GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPW 728
>UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24;
Euteleostomi|Rep: Activated CDC42 kinase 1 - Homo
sapiens (Human)
Length = 1036
Score = 171 bits (415), Expect = 4e-41
Identities = 94/228 (41%), Positives = 126/228 (55%), Gaps = 12/228 (5%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTM----ALKDFLEEASI 297
I D+ + KLG G +G V W + ++VAVK LK D + A+ DF+ E +
Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + H NL++L GV PP ++TE G+LL+ LR + G L A Q+A
Sbjct: 181 MHSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGT--LSRYAVQVA 237
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWT 415
GM YLES+ FIHRDLAARN L+ LVK+ DFGL R + DD Y K P W
Sbjct: 238 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 297
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L TFS SD W FG+ LWE+ TYG P+ G++ + + H ++K
Sbjct: 298 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 345
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 170 bits (414), Expect = 6e-41
Identities = 91/224 (40%), Positives = 138/224 (61%), Gaps = 11/224 (4%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN--ITVAVKTLKDDTMAL--KDFLEEASIMKE 300
ID + I +++G G++G V E +K + + VA+KTL D + K+FL EA +M
Sbjct: 558 IDASLIERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCG 617
Query: 301 MRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGM 360
+ HP +V+L+GVC PP ++ E +S+G LL++L+ + + + + ++ ATQIASGM
Sbjct: 618 LDHPCIVKLMGVCLG-PPMMLVQELVSQGALLDFLQ---NDSITASDLKLW-ATQIASGM 672
Query: 361 SYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAPE 418
YLE + F+HRDLAARN L+ K++DFGL+R +D Y + G ++P+KW APE
Sbjct: 673 MYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPE 732
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
+ Y TFS SDVW FG+ LWE+ + G PY A+V +E
Sbjct: 733 SIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIE 776
Score = 62.5 bits (145), Expect = 2e-08
Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 3/102 (2%)
Query: 128 VNSLEKHSWYHGPISRNAA-EYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRI 185
V L+ W+HG + R A E + G +G FL+R S + P +S+ G V+++ I
Sbjct: 343 VPRLQGKPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEI 402
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAP 227
N + Y+ F TL +L+ H+S DGL T LL+P P
Sbjct: 403 NTKMES-FYIDDGPYFDTLEQLIDHYSRYDDGLPTMLLHPIP 443
Score = 52.4 bits (120), Expect = 2e-05
Identities = 28/89 (31%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 136 WYHGPISRNAAEYLLSSGING--SFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
W+HG I+R+ A ++L +G +FLVRES S G +S+ + G H++I D
Sbjct: 76 WFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLPQHFQIQCMGDFYY 135
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQL 222
+ + F L +L++++ + +GL T+L
Sbjct: 136 KIDNGPLFQGLDQLINYYRMGSNGLPTKL 164
>UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 419
Score = 170 bits (414), Expect = 6e-41
Identities = 118/335 (35%), Positives = 181/335 (54%), Gaps = 27/335 (8%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESE---SSPGQRSISLRYEGRVYHYRINEDADGK 192
WYHG + R LL + +G FLVR S + +S++++G+ +H+++ E DG
Sbjct: 32 WYHGLLPRADINTLLEN--DGDFLVRTSHIVGQDSAKTVLSVKWKGKCHHWQLQEKEDGS 89
Query: 193 VYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVM 252
+ V E KF ++ ++V ++ L PA + P+ D WE+ I +
Sbjct: 90 I-VIEERKFESVLDMVT--TLRMKRLPVSANCPALLLN-----PINKQD-WELRHDQIKL 140
Query: 253 KHKLGGGQYGDVYEAAW--KRGNITVAVKTLKDD----TMAL-KDFLEEASIMKEMRHPN 305
LG G +G VY+AA+ K VAVK K + T A+ +D +EA IM++ +HPN
Sbjct: 141 GKMLGEGAFGGVYKAAFYCKGEKRMVAVKVNKGNEKISTRAMIEDVCKEARIMRQYQHPN 200
Query: 306 LVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLES 365
+V GVC + P ++ E S+G L +L+ + V L Y + + G+ YL
Sbjct: 201 VVCFFGVCVEKEPIMLVMELASQGALDSFLK-NEKNNVSLRDKLKY-SFDASKGLEYLHQ 258
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYT---AHAGAKFPIKWTAPEGLAY 422
IHRD+AARN L+ +N +VK+ DFGL++ + D + AK PI+W APE +
Sbjct: 259 HGCIHRDVAARNFLMHKN-VVKITDFGLSKQLSDLAHKYKLKDIQAKLPIRWLAPEVIVT 317
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
T++ KSDV++FGILLWEI G PYPG+ LA+V
Sbjct: 318 ATYTFKSDVYSFGILLWEIFMDGAIPYPGMKLAEV 352
>UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror2 precursor; n=2; Sophophora|Rep:
Tyrosine-protein kinase transmembrane receptor Ror2
precursor - Drosophila melanogaster (Fruit fly)
Length = 724
Score = 170 bits (414), Expect = 6e-41
Identities = 108/295 (36%), Positives = 153/295 (51%), Gaps = 23/295 (7%)
Query: 187 EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEID 246
E G + +K+GT+ HS L T K +KP A + E
Sbjct: 383 ETLGGNGNTNTLAKWGTIRSTATIHSNCV-ALTTVTNVSDAKGTKPN----ARLEKLEYP 437
Query: 247 RTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDT--MALKDFLEEASIMK 299
R DIV LG G +G V++A + ++ VAVK LKDD DF EA ++
Sbjct: 438 RGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLA 497
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV----------L 349
E HPN+V+LLGVC P ++ E+M+ G+L E+LRA + A L
Sbjct: 498 EFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHL 557
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLA-RLMRDDTYTAHAGA 408
+ MA IA+GM YL R F+HRDLA RNCL+ E+ VK+ADFGL+ ++ D Y
Sbjct: 558 LQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDEND 617
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PI+W E + YN FS +SDVWA+GI LWE+ ++ + PY G+ +V +++
Sbjct: 618 FIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKE 672
>UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-oncogene
c-ros-1 protein precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to proto-oncogene c-ros-1 protein
precursor - Apis mellifera
Length = 2105
Score = 170 bits (413), Expect = 8e-41
Identities = 96/233 (41%), Positives = 133/233 (57%), Gaps = 18/233 (7%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNIT-VAVKTLKDDTMALK--DFLEEASI 297
+I R I + LG G +G+V++ K R IT VA+KTL+ A + +FL+EA +
Sbjct: 1801 KIRREQITLAKFLGSGAFGEVFQGNAKDLERPGITPVAIKTLRKGASAQEKTEFLQEARL 1860
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG------AVVLMY 351
M RH ++++LLGVC P ++ E M G+LL YLRA +R P L+
Sbjct: 1861 MSHFRHKHVLRLLGVCLDTDPPLLVLELMEAGDLLSYLRA-SRSLQPSDSHALRLQDLLA 1919
Query: 352 MATQIASGMSYLESRSFIHRDLAARNCLVG----ENHLVKVADFGLAR-LMRDDTYTAHA 406
M +A G YLE F+HRDLA RNCLV EN +VK+ DFGLAR + ++D Y
Sbjct: 1920 MCEDVARGCRYLEELHFVHRDLACRNCLVSAKDRENRVVKIGDFGLARDIYKNDYYRKEG 1979
Query: 407 GAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
P++W APE L F+++SDVWAFG+L+WEI + G PYP +V H
Sbjct: 1980 EGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQQPYPARTNIEVLH 2032
>UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whole
genome shotgun sequence; n=8; Euteleostomi|Rep:
Chromosome undetermined SCAF15024, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 511
Score = 170 bits (413), Expect = 8e-41
Identities = 109/291 (37%), Positives = 172/291 (59%), Gaps = 29/291 (9%)
Query: 67 EEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTL-TGAVGWVPSNYV 125
E+ ++ +ALY ++A + L KKGE+++I+ + GEW A +L T G++PSNYV
Sbjct: 14 EKGVEKIVIALYPYEALHPDDLGFKKGERMKILE--ERGEWWRAKSLSTNREGFIPSNYV 71
Query: 126 TPVNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRY--EGR-- 179
+++E W+ ISR AE L + N GS+L+RESE++ G S+S+R +G
Sbjct: 72 GQADTMETEDWFFKDISRKDAERQLLAPANRAGSYLIRESETAKGSFSLSVRDVDDGGTD 131
Query: 180 -VYHYRINEDADGKVYVTSESKFGTLAELV-HHHSV--------AGDGLITQLLYPA--P 227
V HY+I +G Y++ + F ++ ++ H+H+ DGL +L P P
Sbjct: 132 LVKHYKIRLLDNGGYYISPKISFTDISSMIKHYHNRNPEPEPPGKADGLCRKLDRPCVKP 191
Query: 228 KRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT-VAVKTLKDDTM 286
K KP D WEI + I M +LG GQ+G+V+ A + NIT VAVKTLK TM
Sbjct: 192 KAEKPW-----DKDAWEISKDSIRMVKRLGAGQFGEVWMAYYN--NITRVAVKTLKPGTM 244
Query: 287 ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA 337
++ F++EA++MK+++H LV+L V T+ P YIITE+M+ G+LL++L++
Sbjct: 245 TVEAFMDEANLMKKLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKS 295
Score = 146 bits (353), Expect = 1e-33
Identities = 64/114 (56%), Positives = 85/114 (74%)
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAK 409
M + QIA GM+Y+E R++IHRDL A N LV E L K+ADFGLAR++ DD Y+A GAK
Sbjct: 344 MCICGQIAEGMAYIERRNYIHRDLRAANVLVSECLLCKIADFGLARVIEDDEYSAREGAK 403
Query: 410 FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
FPIKWTAPE + Y +F+ KSD+W+FG+LL+EI TYG PYPG+ +V +++
Sbjct: 404 FPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMTKGEVISSIQR 457
>UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep:
Tyrosine kinase - Schistosoma mansoni (Blood fluke)
Length = 1264
Score = 170 bits (413), Expect = 8e-41
Identities = 88/238 (36%), Positives = 143/238 (60%), Gaps = 12/238 (5%)
Query: 234 VFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMAL-- 288
++ PP ++ ++ + +K +LGGG +G V + ++ + + VAVKTLK + +A
Sbjct: 872 IYDELPPSNFLLNSQTVTLKERLGGGNFGHVVKGLYRTPSGQEVPVAVKTLKPNQIANSG 931
Query: 289 -KDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAV 347
++ L EA M +++H ++V+L+GVC +E F ++ E G + +YL+ V
Sbjct: 932 EREILAEARTMAQLKHRHIVRLIGVC-KEEQFMLVLELAPLGPINKYLKKRPDVSVHTLT 990
Query: 348 VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAH 405
LM+ Q+A GM+YLES F+HRDLAARN L+ H K++DFG+++ + D Y A
Sbjct: 991 ELMH---QVALGMAYLESCKFVHRDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAA 1047
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
K+P+KW APE + Y F +KSDVW++GI LWE+ +YG PY + A + ML++
Sbjct: 1048 TAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQ 1105
Score = 57.6 bits (133), Expect = 7e-07
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 4/96 (4%)
Query: 132 EKHSWYHGPISRNAAEYLL-SSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINEDA 189
E ++++G I+R AE LL ++G N G FL+RES + ++S+ + GRV+HY +
Sbjct: 45 ESTNYFYGKITREQAEELLFTNGANEGLFLLRESVNR--NYAVSICHLGRVHHYNVERHT 102
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYP 225
D + + KF ELV HHS DG +T P
Sbjct: 103 DCSYRIQTGHKFIGPVELVQHHSTQLDGFLTLAQLP 138
Score = 46.8 bits (106), Expect = 0.001
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 136 WYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
WYH I R AE L+S N G+FLVR + +SL + HYRI E +
Sbjct: 202 WYHHTIRRYEAESRLASEGNQDGAFLVRYRKEDRTY-VLSLTSQNEPKHYRIEEYLS-RW 259
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYPAP 227
+ F T+ EL+ H+ DGL+ +L P P
Sbjct: 260 SIEGGQYFETIMELIDHYHFRQDGLLCKLQKPIP 293
>UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2;
Culicidae|Rep: Tyrosine protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 722
Score = 170 bits (413), Expect = 8e-41
Identities = 92/235 (39%), Positives = 132/235 (56%), Gaps = 14/235 (5%)
Query: 232 PTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLK--DDTM 286
P+ P+ D WE+ + +V+ +LG G +G VY + G+ VAVKTLK T
Sbjct: 275 PSSIPVNTLDKWEVPKDRVVINRRLGEGAFGTVYGGEAQIGDEGWTAVAVKTLKIGSTTE 334
Query: 287 ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-----GARE 341
DFL EA MK H N+V+LLGVC + P Y I EFM G+L YL A +++
Sbjct: 335 DKVDFLSEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHLVNSKQ 394
Query: 342 CVPGAVV---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LM 397
+ L MA ++ +SYL + ++HRDLA RNC+V +VK+ DFG+AR
Sbjct: 395 SEDSDISPKRLTMMALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVVKLGDFGMARPTF 454
Query: 398 RDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
+D Y + P++W APE LA F+ SDVW++G+LL+EI ++G PY G+
Sbjct: 455 ENDYYRFNRKGMLPVRWMAPESLALGIFTPASDVWSYGVLLYEIISFGSFPYQGM 509
>UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3
precursor; n=30; Tetrapoda|Rep: Tyrosine-protein kinase
receptor TYRO3 precursor - Homo sapiens (Human)
Length = 890
Score = 169 bits (412), Expect = 1e-40
Identities = 97/233 (41%), Positives = 135/233 (57%), Gaps = 16/233 (6%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMA---LKDFLEEASIM 298
I + LG G++G V EA K+ + + VAVK LK D +A +++FL EA+ M
Sbjct: 513 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 572
Query: 299 KEMRHPNLVQLLGVCTRE------PPFYIITEFMSRGNLLEYL---RAGARECVPGAVVL 349
KE HP++ +L+GV R P +I FM G+L +L R G L
Sbjct: 573 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 632
Query: 350 MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGA 408
+ IA GM YL SR+FIHRDLAARNC++ E+ V VADFGL+R + D Y +
Sbjct: 633 IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 692
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
K P+KW A E LA N ++ +SDVWAFG+ +WEI T G +PY G++ A++Y+ L
Sbjct: 693 KLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL 745
>UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=53; Euteleostomi|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Homo sapiens (Human)
Length = 869
Score = 169 bits (412), Expect = 1e-40
Identities = 98/245 (40%), Positives = 142/245 (57%), Gaps = 29/245 (11%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMA--LKDFLEEAS 296
E R +I +G G +G V++A VAVK LK++ A DF EA+
Sbjct: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV------------- 343
+M E +PN+V+LLGVC P ++ E+M+ G+L E+LR+ + V
Sbjct: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
Query: 344 ---PGAVVL-----MYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR 395
PG L + +A Q+A+GM+YL R F+HRDLA RNCLVGEN +VK+ADFGL+R
Sbjct: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
Query: 396 -LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDL 454
+ D Y A+ PI+W PE + YN ++T+SDVWA+G++LWEI +YG+ PY G+
Sbjct: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
Query: 455 ADVYH 459
+V +
Sbjct: 809 EEVIY 813
>UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=22;
Euteleostomi|Rep: Ephrin type-A receptor 8 precursor -
Homo sapiens (Human)
Length = 1005
Score = 169 bits (412), Expect = 1e-40
Identities = 91/227 (40%), Positives = 136/227 (59%), Gaps = 9/227 (3%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWK---RGNITVAVKTLKDD--TMALKDFLEEASIM 298
EI+ + I ++ +G G G+V + + ++ VA+K LK +DFL EASIM
Sbjct: 629 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 688
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ HPN+++L GV TR I+TE+M G+L +LR + + L+ M + +
Sbjct: 689 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFT--IMQLVGMLRGVGA 746
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA--GAKFPIKWTA 416
GM YL ++HRDLAARN LV N + KV+DFGL+R++ DD A+ G K PI+WTA
Sbjct: 747 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 806
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
PE +A+ TFS+ SDVW+FG+++WE+ YG PY + DV +E+
Sbjct: 807 PEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEE 853
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 169 bits (411), Expect = 1e-40
Identities = 91/238 (38%), Positives = 143/238 (60%), Gaps = 15/238 (6%)
Query: 236 PLAPPDHW---EIDRTDIVMKH-KLGGGQYGDVYEAAW--KRGNITVAVKTLK--DDTMA 287
P A PD +++R+D+ ++ +LG G +G V + K+ VAVK LK DD A
Sbjct: 304 PYADPDELRSTKVNRSDLTLEDGELGSGNFGTVLRGVYQMKKTQKVVAVKILKNDDDNAA 363
Query: 288 LKD-FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGA 346
+KD L EA++M+++ +P +V+++G+C E ++ E G L ++L+ V
Sbjct: 364 VKDEMLREANVMQQLDNPYIVRMIGICEAEN-LMLVMELAELGPLHKFLQKNKHITVKNL 422
Query: 347 VVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTA 404
L++ Q++ GM YLE +F+HRDLAARN L+ H K++DFGL++ + +D Y A
Sbjct: 423 TELVH---QVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKA 479
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
K+P+KW APE + Y FS+KSDVW+FG+L+WE +YG PY G+ +V M+E
Sbjct: 480 KGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIE 537
Score = 62.1 bits (144), Expect = 3e-08
Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 132 EKHSWYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQR---SISLRYEGRVYHYRIN 186
EK W+HG I R +E L +S +NG + +R ++ L + +V HYRI+
Sbjct: 159 EKMPWFHGKIDREDSELRLLNTSRVNGQISNQTKRKQWQKRVPNALCLLHNNQVMHYRID 218
Query: 187 EDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRS 230
+D GK+ + KF TL +LV H+S DGL+ L P+ S
Sbjct: 219 KDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPS 262
Score = 54.8 bits (126), Expect = 5e-06
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 4/105 (3%)
Query: 136 WYHGPISRNAAEYLLSSGINGS--FLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
++ G I+R +E L G +G +L+R+S S G ++SL Y + YHY I + +
Sbjct: 10 YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTY 69
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYP--APKRSKPTVFP 236
+ T +++++HS DGLI L P P+ ++P V P
Sbjct: 70 AIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEPKVGP 114
>UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1;
Ciona intestinalis|Rep: Epidermal growth factor receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 878
Score = 169 bits (411), Expect = 1e-40
Identities = 92/225 (40%), Positives = 136/225 (60%), Gaps = 16/225 (7%)
Query: 256 LGGGQYGDVYEAAW-------KRGNITVAVKTLKDDT--MALKDFLEEASIMKEMRHPNL 306
LG G +G V++ W +R + VA+K L+D++ +A + L+EA +M HPNL
Sbjct: 129 LGSGAFGTVHKGYWIPDLAPRERVKVPVAIKVLRDESSQVASNEILDEAFVMASCEHPNL 188
Query: 307 VQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL-ES 365
V+LLG+ + +IT+ M GNLLEY+R G+ L+ + QIA GM YL E
Sbjct: 189 VRLLGISLSQR-IMLITQLMPLGNLLEYVRDNKDNI--GSQHLLNWSLQIAKGMKYLSEE 245
Query: 366 RSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAPEGLAYN 423
+ +HRDLAARN LV + V++ DFGLA+L+ ++D Y A G K PIKW A E + +
Sbjct: 246 KHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVKEDVYRAEGG-KMPIKWLALESIQHR 304
Query: 424 TFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
F+ KSDVW+FG+ +WE+ T+G PY V +V+ +LE+ + P
Sbjct: 305 IFTQKSDVWSFGVTMWELMTFGKKPYESVPAREVHTLLERGERLP 349
>UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=2;
Caenorhabditis|Rep: Defective spermatogenesis protein 8
- Caenorhabditis elegans
Length = 512
Score = 169 bits (411), Expect = 1e-40
Identities = 107/341 (31%), Positives = 181/341 (53%), Gaps = 29/341 (8%)
Query: 120 VPSNYVTPV-NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRS---ISLR 175
VPS+ V V N+++ +YHG + RN E +LS+ +G FL+R +E G+R IS++
Sbjct: 97 VPSDEVGRVENNIDNFPFYHGFMGRNECEAMLSN--HGDFLIRMTEI--GKRVAYVISIK 152
Query: 176 YEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVF 235
++ + H + K+Y T + F ++ EL+ +H P T+
Sbjct: 153 WKYQNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHK----------RNHKPIYEGMTLI 202
Query: 236 PLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRG----NITVAVKTLKDDTMALKD- 290
W+++ + + KLG GQ+G+V++ + K +TVAVKTL + ++ +
Sbjct: 203 CGLARHGWQLNNEQVTLNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEK 262
Query: 291 --FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV 348
FL EA++M + HPN+++ GVCT + P I+ EF G LE E V
Sbjct: 263 ILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEFCD-GKSLEDALLSKEEKVSAEDK 321
Query: 349 LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGA 408
++Y+ A G+ YL + IHRD+AARNCL+ ++K++DFGL+ ++ G
Sbjct: 322 ILYLF-HAACGIDYLHGKQVIHRDIAARNCLLNSKKILKISDFGLS--VKGVAIKERKGG 378
Query: 409 KFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
P+K+ APE L +ST SD++++G L++E+ T G +P+
Sbjct: 379 CLPVKYMAPETLKKGLYSTASDIYSYGALMYEVYTDGKTPF 419
>UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13;
Euteleostomi|Rep: Activated CDC42 kinase 2 - Bos taurus
(Bovine)
Length = 747
Score = 169 bits (411), Expect = 1e-40
Identities = 93/228 (40%), Positives = 126/228 (55%), Gaps = 12/228 (5%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTM----ALKDFLEEASI 297
I D+ + KLG G +G V W + ++VAVK LK D + A+ DF+ E +
Sbjct: 121 IGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + H NL++L GV PP ++TE G+LL+ LR + G L A Q+A
Sbjct: 181 MHSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGT--LSRYAVQVA 237
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWT 415
GM YLE++ FIHRDLAARN L+ LVK+ DFGL R + DD Y K P W
Sbjct: 238 EGMGYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 297
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L TFS SD W FG+ LWE+ TYG P+ G++ + + H ++K
Sbjct: 298 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 345
>UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 169 bits (410), Expect = 2e-40
Identities = 95/215 (44%), Positives = 131/215 (60%), Gaps = 12/215 (5%)
Query: 256 LGGGQYGDVYEAAW----KRGNITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNLVQL 309
LG G +G VY+ W + I VA+K L T A ++FL EA IM + H NL++L
Sbjct: 843 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKL 902
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
L VC +IT+ M G LL+Y+R R+ + G+ L+ +TQIA GMSYLE + +
Sbjct: 903 LAVCMSSQ-MMLITQLMPLGCLLDYVRNN-RDKI-GSKALLNWSTQIAKGMSYLEEKRLV 959
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNTFST 427
HRDLAARN LV LVK+ DFGLA+L+ D+ Y A AG K PIKW A E + F++
Sbjct: 960 HRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTS 1018
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
KSDVWAFG+ +WE+ T+G P+ + D+ ++E
Sbjct: 1019 KSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1053
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila
melanogaster|Rep: Tyrosine-protein kinase transmembrane
receptor Ror precursor - Drosophila melanogaster (Fruit
fly)
Length = 685
Score = 169 bits (410), Expect = 2e-40
Identities = 83/221 (37%), Positives = 135/221 (61%), Gaps = 8/221 (3%)
Query: 249 DIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMAL--KDFLEEASIMKEMRH 303
D+ +LG G +G VY+ + N ITVA+K LK++ +DF E ++ +++H
Sbjct: 409 DVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKH 468
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYM--ATQIASGMS 361
N+V +LGV + P+ ++ E+M+ G+L E+L + + L ++ A QI+ GM
Sbjct: 469 QNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQ 528
Query: 362 YLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGL 420
YL + ++HRDLAARNCLV E +VK++DFGL+R + D Y + + P++W E +
Sbjct: 529 YLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESI 588
Query: 421 AYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
Y F+T+SDVW+FG++LWEI +YGM PY G +V +++
Sbjct: 589 LYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLI 629
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 169 bits (410), Expect = 2e-40
Identities = 92/211 (43%), Positives = 123/211 (58%), Gaps = 11/211 (5%)
Query: 256 LGGGQYGDVYEAAWKRGN---ITVAVKTLK--DDTMALKDFLEEASIMKEMRHPNLVQLL 310
+G G +G VY + I AVK+L D + FL E IMK+ HPN++ LL
Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143
Query: 311 GVCTR-EPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
G+C R E ++ +M G+L ++R P L+ Q+A GM YL S+ F+
Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHN--PTVKDLIGFGLQVAKGMKYLASKKFV 1201
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRD-DTYTAH--AGAKFPIKWTAPEGLAYNTFS 426
HRDLAARNC++ E VKVADFGLAR M D + Y+ H GAK P+KW A E L F+
Sbjct: 1202 HRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT 1261
Query: 427 TKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
TKSDVW+FG++LWE+ T G PYP V+ D+
Sbjct: 1262 TKSDVWSFGVVLWELMTRGAPPYPDVNTFDI 1292
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 169 bits (410), Expect = 2e-40
Identities = 103/245 (42%), Positives = 141/245 (57%), Gaps = 29/245 (11%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLK----DDTMALKD 290
FPL +WE+ R+ +V+ LG G +G V A + N VAVK +K DD +A
Sbjct: 403 FPL--DSNWELPRSHLVLGATLGEGAFGRVVMA--EVNNAIVAVKMVKEGHTDDDIA--S 456
Query: 291 FLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYL---RAGARE----- 341
+ E +MK + RH N++ LLG C++ P Y+I E+ GNL ++L R R+
Sbjct: 457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDS 516
Query: 342 -----CVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
P V+ L+ A QIA GM YL SR IHRDLAARN LV +++++K+ADFG
Sbjct: 517 SQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
Query: 393 LAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
LAR + D Y + + PIKW APE L + +KSDVW++GILLWEI TYG PYP
Sbjct: 577 LARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPT 636
Query: 452 VDLAD 456
+ A+
Sbjct: 637 IMSAE 641
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 168 bits (409), Expect = 2e-40
Identities = 94/233 (40%), Positives = 133/233 (57%), Gaps = 17/233 (7%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWK------RGNITVAVKTLKDDTMAL--KDFL 292
D WE+DR I + +LG G +G VYE K I VAVKT+ D ++FL
Sbjct: 1028 DEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRREFL 1087
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGAR--ECVPGAVV-- 348
+EA+ MKE ++V+LLGV + P +I E M+ G+L YLR G R E PG +
Sbjct: 1088 KEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLR-GHRPDEDHPGVMPPH 1146
Query: 349 ---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++ MA +IA GM+YL + F+HRDLAARNC+V E VK+ DFG+ R + D Y
Sbjct: 1147 LLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIYETDYYRK 1206
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
P++W APE L F++ SDVW++G+++WE+ T PY G+ +V
Sbjct: 1207 GGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEV 1259
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 168 bits (409), Expect = 2e-40
Identities = 91/240 (37%), Positives = 133/240 (55%), Gaps = 17/240 (7%)
Query: 230 SKPTVFPLAP--PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLK 282
S VFP + PD WE+ R I + +LG G +G VYE + VAVKT+
Sbjct: 1001 SASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 1060
Query: 283 DDTMALK--DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGAR 340
+ + +FL EAS+MK ++V+LLGV ++ P ++ E M+ G+L YLR+
Sbjct: 1061 ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP 1120
Query: 341 ECV-------PGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGL 393
E P ++ MA +IA GM+YL ++ F+HRDLAARNC+V + VK+ DFG+
Sbjct: 1121 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 1180
Query: 394 AR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
R + D Y P++W APE L F+T SD+W+FG++LWEI + PY G+
Sbjct: 1181 TRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL 1240
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 168 bits (408), Expect = 3e-40
Identities = 100/252 (39%), Positives = 139/252 (55%), Gaps = 25/252 (9%)
Query: 236 PLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAW-------KRGNITVAVKTLKD-DTMA 287
P+ PD WE+D + I +G G +G V +A + VAVK L TM
Sbjct: 4 PIPEPDEWEVDYSSIAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATME 63
Query: 288 -LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-----GAR 340
++FL E +MK++ +H N+V +LG T +ITE+ G+L YLRA R
Sbjct: 64 DRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTR 123
Query: 341 ECVPGAVV--------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
+ + G L+ A QIA GM YL + F+HRDLAARN L+ E++LVK++DFG
Sbjct: 124 DSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFG 183
Query: 393 LARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYP 450
L R + + + + H K P+KW APE + N +TKSDVWAFG++LWEI T G SPYP
Sbjct: 184 LTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYP 243
Query: 451 GVDLADVYHMLE 462
G + Y L+
Sbjct: 244 GQSGKEFYKKLK 255
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 168 bits (408), Expect = 3e-40
Identities = 89/228 (39%), Positives = 134/228 (58%), Gaps = 15/228 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK---RGN--ITVAVKTLKDDTMALK--DFL 292
PD WE+ R I + +LG G +G VYE K +G + VAVKT+ + + +FL
Sbjct: 1002 PDEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFL 1061
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--GARECVPGAVV-- 348
EAS+MK ++V+LLGV ++ P +I E M+ G+L YLR+ E PG +
Sbjct: 1062 NEASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPT 1121
Query: 349 ---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++ MA +I+ GM+YL ++ F+HRDLAARNC+V +++ VK+ DFG+ R + D Y
Sbjct: 1122 LKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYETDYYRK 1181
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W +PE L F+ SDVW+FG++LWEI + PY G+
Sbjct: 1182 GGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGL 1229
>UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|Rep:
Focal adhesion kinase - Aedes aegypti (Yellowfever
mosquito)
Length = 1092
Score = 167 bits (407), Expect = 4e-40
Identities = 94/254 (37%), Positives = 140/254 (55%), Gaps = 30/254 (11%)
Query: 242 HWEIDRTDIVMKHKLGGGQYGDVY-------------------------EAAWKRGNITV 276
++E+DR I + +G GQ+GDV+ E K G+I V
Sbjct: 426 NYELDRNHITLNEIIGVGQFGDVHIGSCRLPSKSTLFDELSLSGENNNSEVQQKSGHIQV 485
Query: 277 AVKTLKDDT-MALKD-FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEY 334
AVKT K D +A + FLEEA IM++ HP++++L+G+C+ P +I+ E G L Y
Sbjct: 486 AVKTCKADADLATSEKFLEEAYIMQKFEHPHIIKLIGICSGSP-IWIVMELARLGELRAY 544
Query: 335 LRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLA 394
L+ + G ++L + Q+++ +SYLES+ F+HRD+AARN LV +K+ADFGL+
Sbjct: 545 LKKNGSKLKLGTLLLY--SYQLSTALSYLESKKFVHRDIAARNVLVSSPTCIKLADFGLS 602
Query: 395 RLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDL 454
R + D +Y PIKW APE + + F+T SDVW FG+ WEI G+ P+ G+
Sbjct: 603 RWVEDQSYYTSTKGMLPIKWMAPESINFRRFTTASDVWMFGVCTWEILMLGVKPFQGIKN 662
Query: 455 ADVYHMLEKVKFAP 468
DV LE + P
Sbjct: 663 CDVIGKLENGERLP 676
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 167 bits (407), Expect = 4e-40
Identities = 90/226 (39%), Positives = 133/226 (58%), Gaps = 10/226 (4%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT----VAVKTLKDDTMALK--DFLEEASIM 298
I + I+ + LG G++G VY+ + + +A+K L + T DFL EAS+M
Sbjct: 653 IPKECILTQKVLGRGEFGYVYQGLLRPQEPSDCTPIAIKQLVESTGKRNRVDFLREASVM 712
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+RH +V+L+G+C + PP ++ E + G++L+Y+ A P + L+ A QIA
Sbjct: 713 IRLRHHCIVKLIGIC-KGPPLMMVEELVPLGSMLDYIIANKGTINP-KLELVIWAAQIAC 770
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAHAGAKFPIKWTA 416
GM YLE F+HRDLAARN L+ + K++DFGL+R + DD Y A G K+PIKW A
Sbjct: 771 GMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLSRAIGAGDDYYRASQGGKWPIKWYA 830
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE Y TFS SDVW+FG+ +WE+ + G PY + DV ++E
Sbjct: 831 PESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKLIE 876
Score = 65.7 bits (153), Expect = 2e-09
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 128 VNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 186
+N E W+HG ISR AE +L G NG F+VRES SS G +S+ ++ V HY+I
Sbjct: 1 MNREENLCWFHGKISRERAEEILRQEGGNGVFMVRESTSSEGDFVLSVLFQDEVVHYQIR 60
Query: 187 EDADGKVY-VTSESKFGTLAELVHHHSVAGDGLITQL 222
D + + L L+ H+ + +GL+T+L
Sbjct: 61 RHGDDAFFSIDDHMPIHGLDSLIEHYRESSNGLVTRL 97
Score = 44.0 bits (99), Expect = 0.009
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 155 NGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVA 214
+G +LVR S + G ++L YE H+ I + +Y+ +L L+ H++
Sbjct: 330 SGVYLVRYS-TKHGVDVLTLLYENEAKHFIIQRKQN-YLYIDDGPYMTSLEHLIEHYTRF 387
Query: 215 GDGLITQLLYPAPKRSKPTV 234
DGL T L YP P + KP +
Sbjct: 388 SDGLQTNLRYPVPPKPKPPI 407
>UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23;
Theria|Rep: Tyrosine-protein kinase SYK - Homo sapiens
(Human)
Length = 635
Score = 167 bits (407), Expect = 4e-40
Identities = 91/232 (39%), Positives = 142/232 (61%), Gaps = 12/232 (5%)
Query: 240 PDHWEIDRTDIVMKHK-LGGGQYGDVYEAAWKRGNI--TVAVKTLKDDTM--ALKD-FLE 293
P +DR + ++ K LG G +G V + ++ + TVAVK LK++ ALKD L
Sbjct: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMA 353
EA++M+++ +P +V+++G+C E + ++ E G L +YL+ + L++
Sbjct: 420 EANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH-- 476
Query: 354 TQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTAHAGAKFP 411
Q++ GM YLE +F+HRDLAARN L+ H K++DFGL++ +R D Y A K+P
Sbjct: 477 -QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP 535
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+KW APE + Y FS+KSDVW+FG+L+WE +YG PY G+ ++V MLEK
Sbjct: 536 VKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587
Score = 83.8 bits (198), Expect = 9e-15
Identities = 42/99 (42%), Positives = 60/99 (60%), Gaps = 3/99 (3%)
Query: 132 EKHSWYHGPISRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDA 189
EK W+HG ISR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI++D
Sbjct: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPK 228
GK+ + KF TL +LV H+S DGL+ L P K
Sbjct: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
Score = 53.2 bits (122), Expect = 1e-05
Identities = 31/105 (29%), Positives = 56/105 (53%), Gaps = 4/105 (3%)
Query: 136 WYHGPISRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
++ G I+R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I + +G
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYP--APKRSKPTVFP 236
+ + A+L H+HS DGL+ L P P+ +P P
Sbjct: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGP 119
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 167 bits (407), Expect = 4e-40
Identities = 95/215 (44%), Positives = 130/215 (60%), Gaps = 12/215 (5%)
Query: 256 LGGGQYGDVYEAAW----KRGNITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNLVQL 309
LG G +G VY+ W + I VA+K L T A ++FL EA IM H NL++L
Sbjct: 944 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKL 1003
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
L VC +IT+ M G LL+Y+R R+ + G+ L+ +TQIA GMSYLE + +
Sbjct: 1004 LAVCMSSQ-MMLITQLMPLGCLLDYVRNN-RDKI-GSKALLNWSTQIAKGMSYLEEKRLV 1060
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNTFST 427
HRDLAARN LV LVK+ DFGLA+L+ D+ Y A AG K PIKW A E + F++
Sbjct: 1061 HRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTS 1119
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
KSDVWAFG+ +WE+ T+G P+ + D+ ++E
Sbjct: 1120 KSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1154
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 167 bits (406), Expect = 6e-40
Identities = 97/236 (41%), Positives = 131/236 (55%), Gaps = 22/236 (9%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKDDTMA--LKDFLEEAS 296
E R + + +KLG G + DVY+A K VAVK LK+ D +E S
Sbjct: 307 EFPRNRLTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELS 366
Query: 297 IMKEMR-HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR---------AGARECVPGA 346
+ + HPN+V +LG CT P+YII E++ NL YLR A R
Sbjct: 367 LYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTGESMTADYRNVKKQK 426
Query: 347 VV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD-DT 401
+ L+ QIA GM YL SR IHRDLAARN L+GE ++ KV+DFGLAR + D T
Sbjct: 427 DIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQT 486
Query: 402 YTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
Y + + P++W +PE L +NT++++SDVW+F IL+WEI T G PYPG+ V
Sbjct: 487 YEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGMSSKQV 542
Score = 44.8 bits (101), Expect = 0.005
Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 13/114 (11%)
Query: 209 HHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEA- 267
HH+ V T+ L PA + V + E R + + +KLG G + DVY+A
Sbjct: 102 HHNYVPSP---TKTLMPAIPNLR--VSTMRDETKMEFPRNRLTLLNKLGSGSFADVYKAE 156
Query: 268 ----AWKRGNITVAVKTLKDDTMA--LKDFLEEASIMKEM-RHPNLVQLLGVCT 314
K VAVK LKD D +E S+ + HPN+V +LG CT
Sbjct: 157 ALGIITKEQKTIVAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCT 210
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 167 bits (406), Expect = 6e-40
Identities = 101/246 (41%), Positives = 140/246 (56%), Gaps = 25/246 (10%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKDDTMALK--DFLEEA 295
WE+ ++ + +LG G +G V +A G +TVAVKTLK DFL E
Sbjct: 21 WEVPPQNLSVIKRLGSGNFGHVDKAMAIGIPGFPGQVTVAVKTLKATAQEKDKTDFLTEL 80
Query: 296 SIMKEMR-HPNLVQLLGVCTREPP-----FYIITEFMSRGNLLEYLRAGARE----CV-- 343
++MK +R HP++V+L+G CTR+ II E++ G+LL YLR C
Sbjct: 81 NLMKSLRPHPHVVRLIGCCTRQAGELSNHLAIIFEYLPYGDLLGYLRRSRGHEDWYCSGD 140
Query: 344 ---PGAVV---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM 397
P +V L+ A IA GM++L + +HRDLAARN LVGE++ K++D GLAR +
Sbjct: 141 LRPPSRLVSKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDLGLARDV 200
Query: 398 RDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
D YT + A+ P+KW PE L Y S+ SDVW++GI+LWEI T G SPYPGV +
Sbjct: 201 SQDIYTRTSSARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYPGVKSKGI 260
Query: 458 YHMLEK 463
ML +
Sbjct: 261 PRMLRE 266
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 167 bits (405), Expect = 7e-40
Identities = 93/231 (40%), Positives = 130/231 (56%), Gaps = 13/231 (5%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT---VAVKTLKD--DTMALKDFLEEASIM 298
+I R + + LG G +G+V++ +K VAVKTL + A DF+ EA IM
Sbjct: 914 QIPRDSVTLVKPLGQGAFGEVFQGVYKYSRSEEHPVAVKTLPSVSTSQAEADFMMEALIM 973
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGA-RECVPGAVV---LMYMAT 354
+ HPN+VQ +G+ + P YI+ E ++ G+L +LR R P + L+ A
Sbjct: 974 SKFEHPNIVQFIGISFDKHPRYIVLELLAGGDLKNFLREERPRPDRPTTLTMQSLIMCAY 1033
Query: 355 QIASGMSYLESRSFIHRDLAARNCLV---GENHLVKVADFGLAR-LMRDDTYTAHAGAKF 410
+A G Y+E FIHRD+AARNCL+ G +VK+ADFG+AR + R D Y A
Sbjct: 1034 DVAKGCKYMEEARFIHRDIAARNCLLSCKGPGRVVKIADFGMARDIYRSDYYRKGGKAML 1093
Query: 411 PIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
PIKW PE F+TK+DVWAFG+LLWEI ++G PY G +V M+
Sbjct: 1094 PIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANREVMSMV 1144
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming
protein erbB; n=8; root|Rep: Tyrosine-protein kinase
transforming protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 167 bits (405), Expect = 7e-40
Identities = 88/220 (40%), Positives = 132/220 (60%), Gaps = 10/220 (4%)
Query: 256 LGGGQYGDVYEAAW----KRGNITVAVKTLKDDTM--ALKDFLEEASIMKEMRHPNLVQL 309
LG G +G VY+ W ++ I VA+K L++ T A K+ L+EA +M + +P++ +L
Sbjct: 138 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 197
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
LG+C +IT+ M G LL+Y+R G+ L+ QIA GM+YLE R +
Sbjct: 198 LGICLTST-VQLITQLMPYGCLLDYIREHKDNI--GSQYLLNWCVQIAKGMNYLEERRLV 254
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-GAKFPIKWTAPEGLAYNTFSTK 428
HRDLAARN LV VK+ DFGLA+L+ D HA G K PIKW A E + + ++ +
Sbjct: 255 HRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIYTHQ 314
Query: 429 SDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
SDVW++G+ +WE+ T+G PY G+ +++ +LEK + P
Sbjct: 315 SDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLP 354
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 166 bits (404), Expect = 1e-39
Identities = 98/253 (38%), Positives = 146/253 (57%), Gaps = 25/253 (9%)
Query: 228 KRSKPTVFPLAPPD-HWEIDRTDIVMKHKLGGGQYGDVYEAAWKR-GN-ITVAVKTLKDD 284
+R KPT L P WE DI + +G G +G V +A K+ GN ++ A+K LK+
Sbjct: 660 RRPKPTPEALTYPILEWE----DIKFEDVIGEGNFGQVIKAMVKKDGNKMSAAIKMLKEF 715
Query: 285 TMAL--KDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR----- 336
+DF E ++ ++ +HPN++ L+G C YI E+ GNLL++LR
Sbjct: 716 ASENDHRDFAGELEVLCKLGQHPNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVL 775
Query: 337 ----AGARECVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKV 388
A A+E + + L+ A +A+GM YL + FIHRDLAARN LVG+N + K+
Sbjct: 776 ETDPAFAKEHGTASTLTSQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKI 835
Query: 389 ADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSP 448
ADFGL+R ++ Y + P++W A E L Y+ ++TKSDVW+FG+LLWEI + G +P
Sbjct: 836 ADFGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP 893
Query: 449 YPGVDLADVYHML 461
Y G+ A++Y L
Sbjct: 894 YCGMTCAELYEKL 906
>UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor
precursor; n=8; Eumetazoa|Rep: Putative insulin-like
peptide receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 1477
Score = 166 bits (404), Expect = 1e-39
Identities = 92/225 (40%), Positives = 131/225 (58%), Gaps = 16/225 (7%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAA----WKRGNITVAVKTLKDDTMALKD---FL 292
PD WE++R I + +LG G +G V+E + VAVKT ++ ++ D L
Sbjct: 1034 PDEWELNREKIELIRELGQGSFGMVFEGIAHGIGDHAELRVAVKTTNENA-SIHDRIQIL 1092
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLM-- 350
+EASIMK ++V+L+GV ++ P +++ E M RG+L YL+ R G + LM
Sbjct: 1093 QEASIMKAFNCNHVVKLIGVVSQGQPTFVVMELMGRGDLKSYLKE--RRPDDGGIPLMRQ 1150
Query: 351 ---YMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAG 407
M +IA GM+YL +R F+H DLAARNC+V + VK+ DFG+AR + + Y G
Sbjct: 1151 EIYQMVAEIADGMAYLAARKFVHCDLAARNCMVASDFTVKIGDFGMARDIYERNYYRKDG 1210
Query: 408 -AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
+ PI+W APE L FST SDVW+FG++LWEI T PY G
Sbjct: 1211 KSLLPIRWMAPESLKDGIFSTASDVWSFGVVLWEICTLASQPYQG 1255
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 166 bits (404), Expect = 1e-39
Identities = 103/251 (41%), Positives = 140/251 (55%), Gaps = 23/251 (9%)
Query: 236 PLAPPDHWEIDRTDIVMKHKLGGGQYGDVY--EAAW---KRGNITVAVKTLKDDTM--AL 288
PL P WE R + + +G G +G V EA + TVAVK LK + M
Sbjct: 627 PLDP--EWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREF 684
Query: 289 KDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--GARECVPG 345
D + E ++MK + ++PN++ LLG CT+E P Y+I EF GNL ++LR+ E
Sbjct: 685 SDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPEEYEKS 744
Query: 346 AVV----------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR 395
++ LM MA Q+A GM +L S+ IHRDLAARN LV E+ +K+ DFGLAR
Sbjct: 745 ILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLAR 804
Query: 396 -LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDL 454
+ D Y + P+KW APE L F+T+SDVW+FGILLWEI T G +PYP V +
Sbjct: 805 DIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPV 864
Query: 455 ADVYHMLEKVK 465
++ L K
Sbjct: 865 EQMFDYLRSGK 875
>UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47;
Euteleostomi|Rep: Protein tyrosine kinase 2 beta - Homo
sapiens (Human)
Length = 1009
Score = 166 bits (404), Expect = 1e-39
Identities = 90/224 (40%), Positives = 130/224 (58%), Gaps = 8/224 (3%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW---KRGNITVAVKTLKDD-TMALKD-FLEEASIMK 299
I R D+V+ LG G +G+VYE + K I VAVKT K D T+ K+ F+ EA IMK
Sbjct: 420 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMK 479
Query: 300 EMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASG 359
+ HP++V+L+G+ EP +II E G L YL + L+ + QI
Sbjct: 480 NLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLK--VLTLVLYSLQICKA 536
Query: 360 MSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEG 419
M+YLES + +HRD+A RN LV VK+ DFGL+R + D+ Y + + PIKW +PE
Sbjct: 537 MAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 596
Query: 420 LAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ + F+T SDVW F + +WEI ++G P+ ++ DV +LEK
Sbjct: 597 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEK 640
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 166 bits (403), Expect = 1e-39
Identities = 88/230 (38%), Positives = 131/230 (56%), Gaps = 17/230 (7%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK----RGNITVAVKTLKDDTMALK--DFLE 293
PD WE+ R I + +LG G +G VYE + + I AVKT+ + + +FL
Sbjct: 970 PDEWEVPRKKIELIRELGQGSFGMVYEGIAQDVRGKAQIKCAVKTVNEHATNRERLEFLN 1029
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV---------- 343
EAS+MK ++V+LLGV ++ P +I E M+ G+L YLR+ +
Sbjct: 1030 EASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKTYLRSHRPDAEVYDPATAKQP 1089
Query: 344 PGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTY 402
P ++ MA +IA GM+YL ++ F+HRDLAARNC+V E+ VK+ DFG+ R + D Y
Sbjct: 1090 PTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYY 1149
Query: 403 TAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W APE L F++ SDVW++G++LWE+AT PY G+
Sbjct: 1150 RKGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGL 1199
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor
- Crassostrea gigas (Pacific oyster) (Crassostrea
angulata)
Length = 804
Score = 166 bits (403), Expect = 1e-39
Identities = 96/243 (39%), Positives = 137/243 (56%), Gaps = 25/243 (10%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKDDTMALK--DFL 292
PD WE++R I + +LG G +G VYE K G I VAVKT+ + + +FL
Sbjct: 325 PDEWEVERDKIQLIRELGQGSFGMVYEGVARDLYGKGGEIKVAVKTVNEHATYRERMEFL 384
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR-------------AGA 339
EAS MK ++V+LLGV + P +I E M +G+L +LR AG
Sbjct: 385 SEASRMKAFSCNHVVRLLGVVSDGQPALLIMELMEKGDLKNFLRMHRPVEEDIDSTFAGI 444
Query: 340 RECV----PGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR 395
+E + P ++ MA +IA GM+YL + F+HRDLAARNC+V E+ VK+ADFG+ R
Sbjct: 445 KEHISRTPPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVKIADFGMTR 504
Query: 396 -LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDL 454
+ D Y A P++W APE L F++ SDVW++G++LWE+AT PY G+
Sbjct: 505 DIYETDYYRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATLAAQPYQGLSN 564
Query: 455 ADV 457
+V
Sbjct: 565 EEV 567
>UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor;
n=49; Euteleostomi|Rep: NT-3 growth factor receptor
precursor - Homo sapiens (Human)
Length = 839
Score = 166 bits (403), Expect = 1e-39
Identities = 97/239 (40%), Positives = 139/239 (58%), Gaps = 34/239 (14%)
Query: 245 IDRTDIVMKHKLGGGQYGDV-----YEAAWKRGNITVAVKTLKDDTMAL-KDFLEEASIM 298
I R DIV+K +LG G +G V Y + + + VAVK LKD T+A KDF EA ++
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 592
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV------P-------G 345
++H ++V+ GVC P ++ E+M G+L ++LRA + + P G
Sbjct: 593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELG 652
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++++A+QIASGM YL S+ F+HRDLA RNCLVG N LVK+ DFG++R + D Y
Sbjct: 653 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRL 712
Query: 405 H--AGAKF------------PIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
+G F PI+W PE + Y F+T+SDVW+FG++LWEI TYG P+
Sbjct: 713 FNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPW 771
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 165 bits (402), Expect = 2e-39
Identities = 97/249 (38%), Positives = 134/249 (53%), Gaps = 22/249 (8%)
Query: 236 PLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEA-----AWKRGNIT-VAVKTLKDDTM--A 287
P + WE R + ++ LG G +G V++A +G VAVKT+K+
Sbjct: 908 PSSQESRWEFPRDKLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDRE 967
Query: 288 LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARE----- 341
+D + E IM+ + HPN+V LLG CT + P Y+I E++ G LL YLR
Sbjct: 968 KEDLVRELEIMQRVGSHPNVVTLLGCCTEQEPHYLILEYVMYGKLLAYLRDHRTRQDFYN 1027
Query: 342 -CVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARL 396
A + L +A GM YL S+ IHRDLAARN LV N L K+ADFG++R
Sbjct: 1028 FSEDSAALTSRDLTVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSRF 1087
Query: 397 MRDD---TYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVD 453
+D T H PI+W APE L Y+ F+TK+DVW+FGIL+WEI T G +PYP +
Sbjct: 1088 ANEDGEVIETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMT 1147
Query: 454 LADVYHMLE 462
+V ++
Sbjct: 1148 AREVMRSVQ 1156
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 165 bits (402), Expect = 2e-39
Identities = 98/264 (37%), Positives = 146/264 (55%), Gaps = 19/264 (7%)
Query: 213 VAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRG 272
VA D ++T+ Y V+ L D +I R + + LG G +G+VY+ +++
Sbjct: 787 VASDSMMTE--YNPNYEFGGVVYTLK--DLKDIPREQLRLVKALGQGAFGEVYQGFYRQR 842
Query: 273 -----NITVAVKTLKD--DTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEF 325
+ VAVKTL + + A DFL EA IM + HPN+V +GVC + P +I+ E
Sbjct: 843 PCDTVEMPVAVKTLPEMSTSQAEMDFLMEALIMSKFNHPNIVHFIGVCFDKHPRFIVLEL 902
Query: 326 MSRGNLLEYLRAGARECVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLV- 380
++ G+L +LR + G+ + L+ +A +A G YLE FIHRD+AARNCL+
Sbjct: 903 LAGGDLKNFLRESRPKPERGSPLTMKDLVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLT 962
Query: 381 --GENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGIL 437
G +VK+ADFG++R + R D Y A PIKW PE F++K+DVW+FG+L
Sbjct: 963 TKGPGRVVKIADFGMSRDVYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGVL 1022
Query: 438 LWEIATYGMSPYPGVDLADVYHML 461
LWEI + G PY G +V ++
Sbjct: 1023 LWEIMSMGYMPYTGCANREVMQLV 1046
>UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 444
Score = 165 bits (402), Expect = 2e-39
Identities = 108/338 (31%), Positives = 178/338 (52%), Gaps = 28/338 (8%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRY-----EGRVYHYRI 185
+ + ++HG + R + LL NG +L+R SE R + + V HY I
Sbjct: 3 INEQPFFHGLLPREEVKLLLQK--NGDYLMRTSEPQGQARHLIISVMQNETSQEVAHYVI 60
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEI 245
+DG +T + KFGTL ELV+HH A I++ + S V P+ WE+
Sbjct: 61 RT-SDGAYSITDKIKFGTLTELVNHHKQAK---ISEEV-----ASSVLVNPIGRQS-WEL 110
Query: 246 DRTDIVMKHKLGGGQYGDVYEAAWKRGNITV--AVKTLKDDTMA---LKDFLEEASIMKE 300
+ DI M LG G +G+V K G+ TV A+K K + + +K+ + EA +M+
Sbjct: 111 NHADITMTKVLGEGAFGEVKLGTLKMGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRG 170
Query: 301 MRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGM 360
H N+V+ GV + P ++ E + G L +YL+ + P + ++ Q+A+G+
Sbjct: 171 FDHKNVVKCYGVAAIDEPLLVVMELVPGGALDKYLQKNSSVQWPEKLDII---AQVAAGL 227
Query: 361 SYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGL 420
+Y+ S++ IHRD+AARN L G+ + KV+DFGL+R+ + Y + PI+W +PE +
Sbjct: 228 AYIHSKNIIHRDIAARNILYGKG-VAKVSDFGLSRVGTE--YQMDPSKRVPIRWLSPETI 284
Query: 421 AYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
++ ++DV+AF IL WE+ G PYP + + V+
Sbjct: 285 VSFLYTPQTDVFAFSILCWEVIENGAQPYPEMLVVQVH 322
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14; Eutheria|Rep:
Insulin receptor-related protein precursor (EC 2.7.10.1)
(IRR) (IR- related receptor) [Contains: Insulin
receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 165 bits (402), Expect = 2e-39
Identities = 89/228 (39%), Positives = 132/228 (57%), Gaps = 15/228 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMALK--DFL 292
PD WE+ R I + +LG G +G VYE + + VA+KT+ + + +FL
Sbjct: 969 PDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFL 1028
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV-------PG 345
+EAS+MK + ++V+LLGV ++ P +I E M+RG+L +LR+ E P
Sbjct: 1029 KEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPA 1088
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
++ MA +IA GM+YL + F+HRDLAARNC+V ++ VK+ DFG+ R + D Y
Sbjct: 1089 LGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRK 1148
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W APE L F+T SDVW+FG++LWEI T PY G+
Sbjct: 1149 GGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL 1196
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 165 bits (401), Expect = 2e-39
Identities = 91/239 (38%), Positives = 137/239 (57%), Gaps = 19/239 (7%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVY-----EAAWKRGNITVAVKTLKDDTMALK--DFLEEA 295
WE R + + LG G++G V E A G TVAVK LK + +++ L E
Sbjct: 766 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEF 825
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGAR-ECV---------PG 345
+++E+ HPN+++LLG CT +I E+ G+L YLR + EC P
Sbjct: 826 QLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPV 885
Query: 346 AV-VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYT 403
V +++ A QI GM+YL +HRDLAARN L+ + + K++DFGL R + DD Y
Sbjct: 886 NVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 945
Query: 404 AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
+ + P+KW APE LA + +++KSDVW+FG+L WE+ T G SPYPG+ +++ +L+
Sbjct: 946 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLK 1004
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 165 bits (401), Expect = 2e-39
Identities = 94/237 (39%), Positives = 134/237 (56%), Gaps = 21/237 (8%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVY--EAA---WKRGNITVAVKTLKDDTMALK--DFLE 293
D WE R + + + LG G +G V+ EA G AVKTLK++ + D L
Sbjct: 375 DRWEFPRHRLKVFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEAERNDLLS 434
Query: 294 EASIMKEMR-HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA-----------GARE 341
E ++K + H N+V+LLG CT + P ++I E+++ G L +LR G +
Sbjct: 435 ELQVLKSLEPHINVVRLLGCCTEKDPIFVILEYVNMGKLQTFLRNSRVEKHYGNTHGKSK 494
Query: 342 CVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDD 400
+ + +M Q+A GM +L SR IHRDLAARN L+ ++H KVADFG AR ++
Sbjct: 495 ILTSGDLTSFMY-QVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARDIVTSK 553
Query: 401 TYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
Y + + PI+W A E L N F+ KSD+W+FGIL+WEI T G +PYPG+ ADV
Sbjct: 554 VYERKSEGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAADV 610
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 165 bits (401), Expect = 2e-39
Identities = 92/226 (40%), Positives = 128/226 (56%), Gaps = 14/226 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKR-----GNITVAVKTLKDDTMALK--DFL 292
PD +EI ++ + ++G G +G VYE K+ VAVKTL + K +FL
Sbjct: 89 PDEYEIPEENVELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFL 148
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV------PGA 346
+EAS+MK ++V+LLGV + +I EFM++G+L YLR+ + P
Sbjct: 149 KEASVMKAFNSHHVVRLLGVVSMSKRPMVIMEFMAKGDLKTYLRSTRPDAEIRKGDPPSL 208
Query: 347 VVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAH 405
+ M +IA GMSYL ++HRDLAARNCLV E+ VK+ DFGL R + D Y
Sbjct: 209 QQKLQMCGEIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDVYETDYYRID 268
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
+ P++W APE L F ++SDVW+FGI+LWEIAT PY G
Sbjct: 269 SRGILPVRWMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQG 314
>UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase receptor;
n=5; Endopterygota|Rep: Muscle-specific tyrosine kinase
receptor - Aedes aegypti (Yellowfever mosquito)
Length = 666
Score = 165 bits (401), Expect = 2e-39
Identities = 98/243 (40%), Positives = 141/243 (58%), Gaps = 28/243 (11%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNIT------VAVKTLKDD-TMALK-DFLEEA 295
E R +I+ LG G +G V++A G I VAVK LKD+ + L+ DF EA
Sbjct: 377 EFPRNNIIYIKDLGQGAFGRVFQAK-APGLIAGEDFTLVAVKMLKDEASQDLQVDFEREA 435
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV------- 348
++ E HPN+V+LLGVC P ++ EFM+RG+L E+LR +C P A
Sbjct: 436 CLLAEFDHPNIVKLLGVCAIGRPMCLLFEFMARGDLNEFLR----QCSPFAQQNRADNIT 491
Query: 349 -------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLA-RLMRDD 400
L+ +A+QIASGM YL R F+HRDLA RNCL+ +N +VK+ADFGL+ ++ D
Sbjct: 492 TELSHGDLLSIASQIASGMVYLSERKFVHRDLATRNCLIDDNMVVKIADFGLSHKIYLQD 551
Query: 401 TYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHM 460
Y PI+W E + YN ++ +SDVWA+G+ LWEI ++ M PY G+ +V
Sbjct: 552 YYKGDENDAIPIRWMPLESILYNKYTIESDVWAYGVCLWEIFSFAMQPYYGMTHEEVVKF 611
Query: 461 LEK 463
+++
Sbjct: 612 VKE 614
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 165 bits (401), Expect = 2e-39
Identities = 92/222 (41%), Positives = 127/222 (57%), Gaps = 11/222 (4%)
Query: 256 LGGGQYGDVYEAAWKR---GNITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNLVQLL 310
+G G +G VY + GN+ AVK+L T +++FL E +MK HP ++ LL
Sbjct: 66 IGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITYLEEVEEFLREGILMKGFHHPQVLSLL 125
Query: 311 GVCT-REPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
GVC R ++ +M G+L ++RA R P L+ Q+A GM YL + F+
Sbjct: 126 GVCLPRHGLPLVVLPYMRHGDLRHFVRAQERS--PTVKELIGFGLQVALGMEYLAQKKFV 183
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNTFS 426
HRDLAARNC++ E VKVADFGLAR + Y + H AK P++W A E L F+
Sbjct: 184 HRDLAARNCMLDETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQKFT 243
Query: 427 TKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
TKSDVW+FG+L+WE+ T G SPYP VD D+ L + + P
Sbjct: 244 TKSDVWSFGVLMWELLTRGASPYPEVDPYDMARYLLRGRRLP 285
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 165 bits (401), Expect = 2e-39
Identities = 91/258 (35%), Positives = 147/258 (56%), Gaps = 31/258 (12%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKDDTMA-- 287
F + WE R ++V+ LG G++G V +A + G TVAVK LK++
Sbjct: 709 FKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE 768
Query: 288 LKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAV 347
L+D L E +++K++ HP++++L G C+++ P +I E+ G+L +LR +R+ PG +
Sbjct: 769 LRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE-SRKVGPGYL 827
Query: 348 V----------------------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHL 385
L+ A QI+ GM YL +HRDLAARN LV E
Sbjct: 828 GSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK 887
Query: 386 VKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATY 444
+K++DFGL+R + +D+Y + + P+KW A E L + ++T+SDVW+FG+LLWEI T
Sbjct: 888 MKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTL 947
Query: 445 GMSPYPGVDLADVYHMLE 462
G +PYPG+ ++++L+
Sbjct: 948 GGNPYPGIPPERLFNLLK 965
>UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3;
Culicidae|Rep: Protein kinase protein - Aedes aegypti
(Yellowfever mosquito)
Length = 1081
Score = 165 bits (400), Expect = 3e-39
Identities = 88/229 (38%), Positives = 132/229 (57%), Gaps = 14/229 (6%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKR--GNIT-VAVKTLKDDTMA----LKDFLEEASI 297
I D+ M KLG G +G V W G I VAVK LK DT+A ++DF +E
Sbjct: 114 IHEKDVTMSVKLGDGSFGVVRRGEWNAPGGQIVPVAVKILKADTLAQPGVIEDFFKEVQA 173
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMY-MATQI 356
M + HPNLV+L GV +P ++TE + G+LL+ LR ++C ++ ++ + Q+
Sbjct: 174 MHTLNHPNLVRLHGVVLSQP-MMMVTELAANGSLLDTLR---KQCKNTSLTTIWNWSVQV 229
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKW 414
A+GM+YLES+ F+HRDLA RN L+ + +K+ DFGL R + ++D Y K P W
Sbjct: 230 ATGMAYLESKRFLHRDLACRNVLLASGNKIKIGDFGLMRALPQQEDCYVMTEHKKVPFPW 289
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L Y FS SD W F + LWE+ T+G P+ G++ + + +++
Sbjct: 290 CAPESLRYRQFSHASDTWMFAVTLWEMFTFGEDPWVGLNGSQILRKIDR 338
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 165 bits (400), Expect = 3e-39
Identities = 92/264 (34%), Positives = 149/264 (56%), Gaps = 31/264 (11%)
Query: 229 RSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAA-----WKRGNITVAVKTLKD 283
RS+ + WE R ++V+ LG G++G V +A + G TVAVK LK+
Sbjct: 365 RSQLETYKRQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKE 424
Query: 284 DTMA--LKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARE 341
+ L+D L E +++K++ HP++++L G C+++ P +I E+ G+L +LR +R+
Sbjct: 425 NASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE-SRK 483
Query: 342 CVPGAVV----------------------LMYMATQIASGMSYLESRSFIHRDLAARNCL 379
PG + L+ A QI+ GM YL +HRDLAARN L
Sbjct: 484 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 543
Query: 380 VGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILL 438
V E +K++DFGL+R + +D+Y + + P+KW A E L + ++T+SDVW+FG+LL
Sbjct: 544 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 603
Query: 439 WEIATYGMSPYPGVDLADVYHMLE 462
WEI T G +PYPG+ ++++L+
Sbjct: 604 WEIVTLGGNPYPGIPPERLFNLLK 627
>UniRef50_P00533 Cluster: Epidermal growth factor receptor
precursor; n=124; root|Rep: Epidermal growth factor
receptor precursor - Homo sapiens (Human)
Length = 1210
Score = 164 bits (399), Expect = 4e-39
Identities = 87/220 (39%), Positives = 132/220 (60%), Gaps = 10/220 (4%)
Query: 256 LGGGQYGDVYEAAW----KRGNITVAVKTLKDDTM--ALKDFLEEASIMKEMRHPNLVQL 309
LG G +G VY+ W ++ I VA+K L++ T A K+ L+EA +M + +P++ +L
Sbjct: 718 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 777
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
LG+C +IT+ M G LL+Y+R G+ L+ QIA GM+YLE R +
Sbjct: 778 LGICLTST-VQLITQLMPFGCLLDYVREHKDNI--GSQYLLNWCVQIAKGMNYLEDRRLV 834
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-GAKFPIKWTAPEGLAYNTFSTK 428
HRDLAARN LV VK+ DFGLA+L+ + HA G K PIKW A E + + ++ +
Sbjct: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQ 894
Query: 429 SDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
SDVW++G+ +WE+ T+G PY G+ +++ +LEK + P
Sbjct: 895 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP 934
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 164 bits (398), Expect = 5e-39
Identities = 92/239 (38%), Positives = 134/239 (56%), Gaps = 21/239 (8%)
Query: 232 PTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTM 286
PTV+ PD WE+ R I +LG G +G VYE K + A+KT+ +
Sbjct: 1067 PTVYV---PDEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHAT 1123
Query: 287 ALK--DFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA---GARE 341
+ +FL EAS+MK ++V+LLGV +R P ++ E M RG+L YLR+ A
Sbjct: 1124 DRERIEFLNEASVMKAFDTFHVVRLLGVVSRGQPTLVVMELMERGDLKTYLRSMRPDAEG 1183
Query: 342 CVPGAVV-------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLA 394
+P + ++ MA +IA GM+YL ++ F+HRDLAARNC+V + VKV DFG+
Sbjct: 1184 SLPSSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMT 1243
Query: 395 R-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
R + D Y P++W +PE L FS+ SD W++G++LWE+AT M PY G+
Sbjct: 1244 RDIYETDYYRKGTKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGL 1302
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|Rep:
Bm-DAF-2 precursor - Brugia malayi (Filarial nematode
worm)
Length = 1456
Score = 164 bits (398), Expect = 5e-39
Identities = 94/237 (39%), Positives = 135/237 (56%), Gaps = 18/237 (7%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITV---AVKTLKDDTMALK--D 290
PD WE+ R+ I ++ ++G G +G VY +T A+KT+ + + +
Sbjct: 1034 PDEWELKRSAIHLEDEIGRGTFGKVYRGYGDNCKSYLGVTFGECAIKTVSETANSAERLH 1093
Query: 291 FLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA---GARECV---- 343
FL EAS+MK+ P +V+L GV + P ++ E M +GNL +YLR+ A E V
Sbjct: 1094 FLIEASVMKQFNTPFIVKLYGVVSDGQPVLVVMEMMKKGNLRDYLRSRRPNAEENVNGLP 1153
Query: 344 -PGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTY 402
PGA+ A+Q+A GM+YLES F HRDLAARNC+V E VK+ DFG+AR + Y
Sbjct: 1154 VPGAIDFFRWASQVADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGMARDIYYHEY 1213
Query: 403 TAHAGAK-FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
AG + P++W APE L F+ KSDVW++GI L+E+ T PY G+ V+
Sbjct: 1214 YKPAGKRLMPVRWMAPESLMDGKFTMKSDVWSYGITLYEMLTLAQQPYLGLANESVF 1270
>UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein ark-1 - Caenorhabditis elegans
Length = 1043
Score = 164 bits (398), Expect = 5e-39
Identities = 96/236 (40%), Positives = 138/236 (58%), Gaps = 12/236 (5%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITVAVKTLKDDTMAL--KDFLEE 294
DH I I + +LG G++G V++A WK I VAVK + D + FL+E
Sbjct: 104 DHHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQE 163
Query: 295 ASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGA-RECVPGAVVLMYMA 353
A+IM MRH ++V+L GV +++E + G+LLE L A R+ P V+ Y A
Sbjct: 164 AAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDY-A 222
Query: 354 TQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMR--DDTYTAH--AGAK 409
QIA GMSYLE + IHRDLAARN LV LVK++DFGL+R + +D Y + K
Sbjct: 223 EQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLK 282
Query: 410 FPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVK 465
PI W APE + + F++KSDVWA+G+ +WE+ +YG P+ G A + ++++ K
Sbjct: 283 LPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKK 338
>UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA;
n=3; Tribolium castaneum|Rep: PREDICTED: similar to
CG14992-PA - Tribolium castaneum
Length = 1000
Score = 163 bits (397), Expect = 7e-39
Identities = 87/228 (38%), Positives = 131/228 (57%), Gaps = 12/228 (5%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMA----LKDFLEEASI 297
I ++I + KLG G +G V W N + VAVK LK D ++ +DF++E
Sbjct: 106 IPESNITLSIKLGDGSFGVVRRGEWTSPNGRVLPVAVKILKADALSQPGVFEDFIKEVQA 165
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + HPNL++L GV +P ++TE + G+LL+YLR ++ P ++ Y ATQ+A
Sbjct: 166 MHVLSHPNLIRLYGVVLSQP-MMMVTELANLGSLLDYLRKQCQQ-TPVPMLCEY-ATQVA 222
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWT 415
+GM+YLES+ F+HRDLA RN L+ +K+ DFGL R + +D Y K P W
Sbjct: 223 TGMAYLESKRFLHRDLACRNVLLASADKIKIGDFGLMRALPQEEDCYVMTEHKKVPFPWC 282
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L FS SD W FG+ +WE+ T+G P+ G+ +++ ++K
Sbjct: 283 APESLRSRQFSHASDTWMFGVTVWEMFTFGEDPWMGLIGSEILRKIDK 330
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 163 bits (397), Expect = 7e-39
Identities = 85/219 (38%), Positives = 123/219 (56%), Gaps = 15/219 (6%)
Query: 256 LGGGQYGDVYEAAWK----RGNITVAVKTLKDDTMALK--DFLEEASIMKEMRHPNLVQL 309
LG G +G+VYE K VA+KTL+ + +FL+EA +M +H ++++L
Sbjct: 1818 LGSGAFGEVYEGIVKGVGGEAETRVAIKTLRKGATEQEKAEFLQEAHLMSNFKHKHILKL 1877
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAG----ARECVPGAVVLMYMATQIASGMSYLES 365
+GVC YI+ E M G+LL YLR+ + + L+ M +A+G YLE
Sbjct: 1878 IGVCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLDLISMCVDVATGCRYLEE 1937
Query: 366 RSFIHRDLAARNCLVGE----NHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGL 420
F+HRDLA RNCLV +VK+ DFGLAR + ++D Y P++W +PE L
Sbjct: 1938 MHFVHRDLACRNCLVSSMDPRERVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESL 1997
Query: 421 AYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
F+++SD+WAFG+LLWEI T G PYP + +V H
Sbjct: 1998 VDGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNVEVLH 2036
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 163 bits (397), Expect = 7e-39
Identities = 94/238 (39%), Positives = 131/238 (55%), Gaps = 21/238 (8%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAW---KRGNITVAVKTLKDDTMAL--KDFLEEASI 297
WEI R +V+K KLG G++G V E + VA+K LK D KD L E +
Sbjct: 1 WEIPRDRVVLKDKLGEGEFGIVMEGELLIEEEAPRKVAIKMLKSDADRTDHKDMLRELDM 60
Query: 298 MKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV-------- 348
K + +H N+V L+G CT P YIITEF++ G LLE LR C+ + V
Sbjct: 61 FKGIGQHENVVSLIGACTLGMPLYIITEFIAGGTLLELLRES--RCITSSYVNANLVSKL 118
Query: 349 ----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYT 403
L+ +A A GM ++ F+HRDLA RN LV E+ K+ DFGL+R + D Y
Sbjct: 119 SGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYL 178
Query: 404 AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHML 461
G K P+KW APE L ++T+SD+W+FG+L+WE+ ++G PY V ++ ML
Sbjct: 179 NAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSML 236
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 163 bits (396), Expect = 9e-39
Identities = 89/248 (35%), Positives = 138/248 (55%), Gaps = 27/248 (10%)
Query: 232 PTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITV--AVKTLKDDTMA-- 287
PT++P+ +D DI + +G G +G V +A K+ + + A+K +K+
Sbjct: 813 PTIYPV-------LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDD 865
Query: 288 LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAG-ARECVPG 345
+DF E ++ ++ HPN++ LLG C Y+ E+ GNLL++LR E P
Sbjct: 866 HRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPA 925
Query: 346 AVV------------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGL 393
+ L++ A +A GM YL + FIHRDLAARN LVGEN++ K+ADFGL
Sbjct: 926 FAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGL 985
Query: 394 ARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVD 453
+R + Y + P++W A E L Y+ ++T SDVW++G+LLWEI + G +PY G+
Sbjct: 986 SR--GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT 1043
Query: 454 LADVYHML 461
A++Y L
Sbjct: 1044 CAELYEKL 1051
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to protein tyrosine kinase - Nasonia
vitripennis
Length = 739
Score = 163 bits (395), Expect = 1e-38
Identities = 90/221 (40%), Positives = 130/221 (58%), Gaps = 8/221 (3%)
Query: 249 DIVMKHKLGGGQYGDVYEAAWKRGNIT---VAVKTLKD--DTMALKDFLEEASIMKEMRH 303
+I++ LG G++G VYE + + T VA+K L+D + ++FL EA +M H
Sbjct: 463 NIILGEVLGEGEFGAVYEGLFDSPSGTQEPVAIKMLRDTHNIATREEFLREARLMMTFNH 522
Query: 304 PNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYL 363
+V+L+G + PP ++ E +S G++L YL P + ++ A+QIA GM YL
Sbjct: 523 HCIVKLIGF-SEGPPLLMVQELVSLGSMLAYLLEFPDRINPNYELKVW-ASQIACGMKYL 580
Query: 364 ESRSFIHRDLAARNCLVGENHLVKVADFGLARLM-RDDTYTAHAGAKFPIKWTAPEGLAY 422
E +HRDLAARN L+ H K++DFGL+R +D Y A AG K+PIKW APE Y
Sbjct: 581 EEIRLVHRDLAARNILLASKHQAKISDFGLSRTFGSNDYYKATAGGKWPIKWYAPESYNY 640
Query: 423 NTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
TFS SDVW++GI LWE+ +YG PY +V ++EK
Sbjct: 641 GTFSHASDVWSYGITLWEMFSYGEQPYGDRRGTEVIDLVEK 681
Score = 60.9 bits (141), Expect = 7e-08
Identities = 34/93 (36%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 136 WYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
W+HG +SR AE LL NG+FLVRES SS G +S+ ++G V HY+I + +
Sbjct: 9 WFHGNLSREDAESLLLEDGRDNGTFLVRESSSSLGDYVLSVLHDGEVAHYQIRKHGEDAF 68
Query: 194 Y-VTSESKFGTLAELVHHHSVAGDGLITQLLYP 225
+ + E+ L L+ ++ D L+T L P
Sbjct: 69 FSIDDETTIHGLETLIEYYQKENDRLVTILQTP 101
Score = 58.4 bits (135), Expect = 4e-07
Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 132 EKHS-WYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINED 188
EK S WYHG + R A LL + ++GSFLVR SE G R +++ Y YH++I +
Sbjct: 278 EKASDWYHGTLDRMEAINLLHKNGDLDGSFLVRLSERHDGIRVLTVMYNKTPYHFQIQKR 337
Query: 189 ADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPP 240
+ +++ + +L ++ H+ DGL L++P KP + P PP
Sbjct: 338 RN-FLFIDNGPYLPSLEHVIEHYRCMPDGLPGPLIHPIAPIPKPPI-PEMPP 387
>UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14482, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 621
Score = 162 bits (394), Expect = 2e-38
Identities = 87/238 (36%), Positives = 143/238 (60%), Gaps = 15/238 (6%)
Query: 236 PLAPPDHWE---IDRTDIVMKH-KLGGGQYGDVYEAAWK--RGNITVAVKTLKDDTMAL- 288
P A PD +DR+ + ++ +LG G +G V + +K + TVAVK LK+D L
Sbjct: 339 PYADPDELRSSTVDRSQLFLEDGELGSGNFGTVMKGIYKMKKTEKTVAVKILKNDEDNLS 398
Query: 289 --KDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGA 346
++ L EA++M+++ +P +V+++G+C E ++ E G L ++L+ + +
Sbjct: 399 VREEMLREANVMQQLDNPYIVRMIGICEAEN-LMLVMELAELGPLHKFLQKHKQISMKNI 457
Query: 347 VVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTA 404
L++ Q++ GM YLE +F+HRDLAARN L+ H K++DFGL++ + +D Y A
Sbjct: 458 TELVH---QVSVGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAVAEDKSYYKA 514
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
K+P+KW APE + Y FS+KSDVW+FG+L+WE ++G PY G+ +V M+E
Sbjct: 515 KGHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSFGQKPYKGMKGNEVMQMIE 572
Score = 83.4 bits (197), Expect = 1e-14
Identities = 41/103 (39%), Positives = 64/103 (62%), Gaps = 3/103 (2%)
Query: 128 VNSLEKHSWYHGPISRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI 185
+ + E+ W+HG I+R +E L +G ING FLVR+ +++ G ++ L +EG+V HYR+
Sbjct: 155 ITAHERMVWFHGAITREGSEPRLQNGSRINGRFLVRQRDTN-GSYALCLLHEGQVMHYRV 213
Query: 186 NEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPK 228
+ D GK+ + KF TL +LV H+S DGL+ L P P+
Sbjct: 214 DRDQAGKLSIPEGKKFDTLWQLVEHYSYKPDGLLHVLTEPCPR 256
Score = 56.8 bits (131), Expect = 1e-06
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 4/103 (3%)
Query: 136 WYHGPISRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
+++G I+R AE YL +G+ +G +L+R+S ++ G ++S+ GR YHY I A+
Sbjct: 10 FFYGNITREEAEDYLQLAGMADGLYLLRQSRNNLGGFALSVSSSGRSYHYSIERQANETY 69
Query: 194 YVTSESKFGTLAELVHHHSVAGDGLITQLLYPA--PKRSKPTV 234
+ +++ +HS DGL+T L P PK KP V
Sbjct: 70 AIPGGKSHQDPVDVIDYHSQVMDGLVTLLKKPCNRPKNVKPKV 112
>UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Receptor tyrosine kinase - Schistosoma
mansoni (Blood fluke)
Length = 1559
Score = 162 bits (394), Expect = 2e-38
Identities = 97/245 (39%), Positives = 139/245 (56%), Gaps = 20/245 (8%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVYEAAWKRGNI--TVAVKTL--KDDTMALKDFLEEASIMK 299
+I DIV+ ++G G +G VY KR VAVK + K DFL EA +M+
Sbjct: 990 DIPPADIVLNRRVGQGAFGMVYGGEAKRNGRWEAVAVKVIGNKSTYEGKTDFLSEAKLMR 1049
Query: 300 EMRHPNLVQLLGVCT--REPPFYIITEFMSRGNLLEYL--RAGARECVPG-----AVVLM 350
+ H N+V+L+G+C +E Y+I EFM G+L YL R + VP L
Sbjct: 1050 SLDHRNVVRLVGICLYPKENHLYLIMEFMLNGDLKTYLLSRRVLAQQVPDHDGVCPATLT 1109
Query: 351 YMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM----RDDTYTAHA 406
MA IA G++YL ++ IHRD+A RNCLVG + +VK+ DFGL R M + Y
Sbjct: 1110 GMAIDIAEGLAYLHRKNLIHRDIACRNCLVGSDGIVKIGDFGLTREMNSSENEGYYRFTR 1169
Query: 407 GAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKF 466
+ PI+W +PE + + FS SD+W++GI+L+EI T+G+ PY G L+DV ++E+VK
Sbjct: 1170 NCELPIRWMSPEAVQFGIFSVHSDIWSYGIVLYEIITFGVFPYDG--LSDV-EIVERVKR 1226
Query: 467 APFVI 471
F I
Sbjct: 1227 KDFSI 1231
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 162 bits (394), Expect = 2e-38
Identities = 98/253 (38%), Positives = 141/253 (55%), Gaps = 25/253 (9%)
Query: 228 KRSKPTVFPLAPPD-HWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITV--AVKTLKDD 284
+R K PL+ P WE DI + +G G +G V A K+ + + A+K LK+
Sbjct: 820 RRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEY 875
Query: 285 TMAL--KDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR----- 336
+DF E ++ ++ HPN++ LLG C YI E+ GNLL++LR
Sbjct: 876 ASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVL 935
Query: 337 ----AGARECVPGAVV----LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKV 388
A ARE + + L+ A+ A+GM YL + FIHRDLAARN LVGEN K+
Sbjct: 936 ETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKI 995
Query: 389 ADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSP 448
ADFGL+R ++ Y + P++W A E L Y+ ++TKSDVW+FG+LLWEI + G +P
Sbjct: 996 ADFGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP 1053
Query: 449 YPGVDLADVYHML 461
Y G+ A++Y L
Sbjct: 1054 YCGMTCAELYEKL 1066
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 162 bits (393), Expect = 2e-38
Identities = 96/241 (39%), Positives = 136/241 (56%), Gaps = 23/241 (9%)
Query: 235 FPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAA----WKRG-NITVAVKTLKDDTM--A 287
+ L WEI R+ + + LG G +G V +A K G + VAVK LK+
Sbjct: 518 YELPMDSDWEIPRSMLCLGKSLGEGAFGKVVKAEAVGLLKPGASSIVAVKMLKEGHTDNE 577
Query: 288 LKDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA--------- 337
+ D + E +MK + +H N++ LLG CT+ P Y++ E+ GNL ++LR
Sbjct: 578 MMDLVSEMEMMKMIGKHNNIINLLGCCTQGGPLYVVVEYAPYGNLRDFLRQHRPSSGYEP 637
Query: 338 --GARECVPGAVV---LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
G E + L+ A Q+A GM YL SR IHRDLAARN LV +++ +K+ADFG
Sbjct: 638 AIGLEEKEKKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADFG 697
Query: 393 LARLMR-DDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
LAR + +D Y + P+KW APE L + ++T+SDVW++GILLWEI T G +PYP
Sbjct: 698 LARDIHCNDYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYPS 757
Query: 452 V 452
V
Sbjct: 758 V 758
>UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n=2;
Danio rerio|Rep: UPI00015A61DF UniRef100 entry - Danio
rerio
Length = 985
Score = 162 bits (393), Expect = 2e-38
Identities = 83/225 (36%), Positives = 135/225 (60%), Gaps = 7/225 (3%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMALKD-FLEEASIM 298
+ I R DIV+ LG G +G+V++ +K + + VAVKT KD + +K+ F+ EA IM
Sbjct: 355 FSISRNDIVLGRILGEGFFGEVHDGIYKSKSGERVNVAVKTCKDCSADVKEKFMSEALIM 414
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
K++ HP++V+L+G+ E P +I+ E G L YL+ + V L+ + QI+
Sbjct: 415 KKLDHPHIVRLIGII-EEDPVWIVMELYPFGELENYLKDNQNKLTN--VTLILYSLQISK 471
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPE 418
++YLE + +HRD+A RN LV + VK+ DFGL+R + ++ Y + + PIKW APE
Sbjct: 472 ALAYLEGVNMVHRDIAVRNVLVAKVDCVKLGDFGLSRYIEEEEYYKASVTRLPIKWMAPE 531
Query: 419 GLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
+ + F++ SDVW F + +WEI + G P+ ++ DV + LE+
Sbjct: 532 SINFRRFTSASDVWMFAVCMWEIMSGGQQPFFWLENKDVINQLEQ 576
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 161 bits (392), Expect = 3e-38
Identities = 85/228 (37%), Positives = 130/228 (57%), Gaps = 15/228 (6%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDDTMALK--DFL 292
PD WE+ R + + +LG G +G VYE K + + AVKT+ ++ + +FL
Sbjct: 1119 PDEWEVPRKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRERVEFL 1178
Query: 293 EEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV-------PG 345
EAS+MK ++V+LLGV ++ P ++ E M G+L YLR+ + P
Sbjct: 1179 NEASVMKGFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRPDVCENFSRQPPT 1238
Query: 346 AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
+M MA +IA GM+YL ++ F+HRDLAARNC+V ++ VK+ DFG+ R + D Y
Sbjct: 1239 LNRIMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMTRDVYETDYYRK 1298
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W APE L F++ SDVW++G++LWE+ T PY G+
Sbjct: 1299 GTKGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGL 1346
>UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, member
2; n=2; Tetrapoda|Rep: Discoidin domain receptor family,
member 2 - Xenopus tropicalis (Western clawed frog)
(Silurana tropicalis)
Length = 879
Score = 161 bits (392), Expect = 3e-38
Identities = 94/224 (41%), Positives = 132/224 (58%), Gaps = 26/224 (11%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVY--EAAWKRGNIT------------VAVKTLKDDTM--A 287
E R + +K KLG GQ+G+V+ EA + + VAVK L+ D A
Sbjct: 579 EFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTA 638
Query: 288 LKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYL-----RAGAREC 342
DFL+E I+ ++HPN+++LLGVC R+ P +ITE+M G+L ++L R+ +
Sbjct: 639 RNDFLKEIKIISRLKHPNIIRLLGVCVRDDPLCMITEYMENGDLNQFLSQREIRSQFTKA 698
Query: 343 --VPGAVV--LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LM 397
+P L+YMA QIA+GM YL S +F+HRDLA RNCLVG ++ +KVADFG++R L
Sbjct: 699 NNIPSVSRQNLLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTIKVADFGMSRNLY 758
Query: 398 RDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEI 441
D Y A PI+W A E + F+T SD WAFG+ LWE+
Sbjct: 759 SGDYYRIQGRAVLPIRWMAWESILLGKFTTCSDAWAFGVTLWEM 802
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 161 bits (392), Expect = 3e-38
Identities = 83/185 (44%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 289 KDFLEEASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR---------AG 338
++FL+E S+MK++ H N+V L T + PF ++ EF+ +G+LL+YLR G
Sbjct: 12 EEFLKEISLMKKLGSHKNIVNFLCCSTVKEPFMLVVEFLPKGDLLDYLRRNRSKQNDETG 71
Query: 339 AREC-VPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-L 396
+E + L+ + QIA+GM YL + F+HRDLAARN LV +N VKVADFGL R L
Sbjct: 72 EQEDEMITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLTRDL 131
Query: 397 MRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLAD 456
+ Y H+ K PIKW +PE + F+T+SDVW++G++LWEIAT G +PYP + D
Sbjct: 132 YEESAYQGHSNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTISTRD 191
Query: 457 VYHML 461
V+ ML
Sbjct: 192 VFVML 196
>UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2;
Schistosoma|Rep: Insulin receptor protein kinase -
Schistosoma mansoni (Blood fluke)
Length = 1499
Score = 161 bits (391), Expect = 4e-38
Identities = 88/194 (45%), Positives = 124/194 (63%), Gaps = 10/194 (5%)
Query: 274 ITVAVKTL-KDDTMA-LKDFLEEASIMKEMRHPNLVQLLGVCTREPPFY--IITEFMSRG 329
+ VAVKTL TM +++F EAS MK++ +VQ LG+ R+P + II E+M+ G
Sbjct: 1248 LEVAVKTLFPASTMDDIREFYNEASFMKQLNCMYIVQFLGIALRQPSSHPVIIMEYMAFG 1307
Query: 330 NLLEYLRA--GARECVPGAV---VLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENH 384
+L YLR +C G++ + + A Q+A+GM+YL IHRDLAARNCLV
Sbjct: 1308 DLATYLRQQMSKDDCPQGSIDTQLAINWAIQLATGMNYLAELHIIHRDLAARNCLVNSML 1367
Query: 385 LVKVADFGLARLMRDDTYTAHAG-AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIAT 443
VK+ADFGLARL+ + Y G A+ P++W APE L+ F+TKSDVW++G++LWEIAT
Sbjct: 1368 TVKIADFGLARLVNNQEYYRKIGQARLPVRWMAPETLSSAYFTTKSDVWSYGVVLWEIAT 1427
Query: 444 YGMSPYPGVDLADV 457
+ PYPG+ +V
Sbjct: 1428 FASLPYPGLSHEEV 1441
>UniRef50_Q613B1 Cluster: Putative uncharacterized protein CBG16480;
n=1; Caenorhabditis briggsae|Rep: Putative
uncharacterized protein CBG16480 - Caenorhabditis
briggsae
Length = 487
Score = 161 bits (391), Expect = 4e-38
Identities = 111/334 (33%), Positives = 168/334 (50%), Gaps = 43/334 (12%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ-RSISLRY-----EGRVYHYRINEDA 189
W+HG + R + LL NG FLVR SE S GQ R + L HY I +A
Sbjct: 67 WFHGLLPREEVQLLLLK--NGDFLVRMSEPSSGQARHLILSVMQNESSQEAMHYVIR-NA 123
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTD 249
DGK +T + F +L EL++HH +L PK P WE++ +D
Sbjct: 124 DGKFSITGKENFDSLIELINHHKQ------NKLHEDNPKSVLINAIGRQP---WELNHSD 174
Query: 250 IVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQL 309
+ M LG G +G+V K G + + + T EA +M+ H N+V+
Sbjct: 175 VTMTKTLGEGAFGEV-----KLGTLKMEITT-------------EARLMRGFNHKNVVRC 216
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
GV + P ++ E + G L YL+ + VP L + TQ+ASG+SY+ S++ +
Sbjct: 217 YGVAAVDEPLLVVMELVKGGGLDGYLQ---KNSVPWPEKLDIL-TQVASGISYIHSKNIM 272
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKS 429
HRD+AARN L G + KV+DFG++R+ + Y + K PI+W +PE L ++ K+
Sbjct: 273 HRDIAARNVLYGGG-VAKVSDFGMSRVGTE--YQMNPNKKVPIRWLSPETLITFVYTQKT 329
Query: 430 DVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
DV+AF +L WE+ G PYP + +V+ + K
Sbjct: 330 DVFAFSVLCWEVIENGTQPYPEFKVVEVHQKVAK 363
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 161 bits (391), Expect = 4e-38
Identities = 89/230 (38%), Positives = 124/230 (53%), Gaps = 19/230 (8%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWK----RGNITVAVKTLKDDTMA--LKDFLEEASIM 298
+D+ + LG G +G+VYE K VA+KTLK ++FL+EA +M
Sbjct: 1800 LDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLM 1859
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV------LMYM 352
+H ++ +LLGVC II E M G+LL YLR +PG L+ M
Sbjct: 1860 SNFKHKHITRLLGVCLEADALLIIMELMQGGDLLSYLRRS--RSLPGQAARLTMLDLISM 1917
Query: 353 ATQIASGMSYLESRSFIHRDLAARNCLVGE----NHLVKVADFGLAR-LMRDDTYTAHAG 407
+ASG YLE F+HRDLA RNCLV + +VK+ DFGLAR + ++D Y
Sbjct: 1918 CQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGE 1977
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
P++W +PE L F+++SD+WAFG+LLWEI T G PY + +V
Sbjct: 1978 GLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEV 2027
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 161 bits (390), Expect = 5e-38
Identities = 87/222 (39%), Positives = 130/222 (58%), Gaps = 11/222 (4%)
Query: 256 LGGGQYGDVYEAAW---KRGNITVAVKTLKDDT--MALKDFLEEASIMKEMRHPNLVQLL 310
+G G +G VY + + I A+K+L T ++ FL E +M+ + HPN++ L+
Sbjct: 1088 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 1147
Query: 311 GV-CTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
G+ E +++ +M G+LL+++R+ R P L+ Q+A GM YL + F+
Sbjct: 1148 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRN--PTVKDLISFGLQVARGMEYLAEQKFV 1205
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNTFS 426
HRDLAARNC++ E+ VKVADFGLAR + D Y + H A+ P+KW A E L F+
Sbjct: 1206 HRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFT 1265
Query: 427 TKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
TKSDVW+FG+LLWE+ T G PY +D D+ H L + + P
Sbjct: 1266 TKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLP 1307
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 160 bits (389), Expect = 6e-38
Identities = 94/233 (40%), Positives = 130/233 (55%), Gaps = 13/233 (5%)
Query: 246 DRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMALKD---FLEEASIMK 299
D I + +G G +G VY N AVK+L T LKD FL E IMK
Sbjct: 1061 DMLRIEDRQVIGKGHFGTVYHGYLIDSNKQETHCAVKSLNRIT-DLKDVDHFLREGLIMK 1119
Query: 300 EMRHPNLVQLLGV-CTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
HPN++ LLG+ +E ++ +M G++ ++R+ R P L+ Q+A
Sbjct: 1120 GFDHPNILSLLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRN--PTVKDLIGFGLQVAK 1177
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA---HAGAKFPIKWT 415
GM YL + F+HRDLAARNC++ E + VKVADFG+AR + D Y + H K P+KW
Sbjct: 1178 GMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYYSIQDHKQVKLPVKWM 1237
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
A E L F++KSDVW++GIL+WE+ T G SPYP VD D+ + L K + P
Sbjct: 1238 AIESLQTQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNYLLKGRRLP 1290
>UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2;
Branchiostoma floridae|Rep: Tyrosine-protein kinase
receptor - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 797
Score = 160 bits (389), Expect = 6e-38
Identities = 86/224 (38%), Positives = 129/224 (57%), Gaps = 19/224 (8%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKR-----GNITVAVKTLKDDTM--ALKDFLEEASI 297
I R I +LG G +G VY ++ VAVKTLK+ ++ A KDF EA +
Sbjct: 505 IQRDTIHFVGELGEGAFGRVYLGKCEKLKPDEDASLVAVKTLKEMSVEDARKDFDREAEL 564
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECV-----PGA------ 346
+ M+H N+V+ GVCT P+ +I E+M G+L YLR+ + P
Sbjct: 565 LTNMQHENIVKFYGVCTEGEPWLMIFEYMENGDLNNYLRSHGPDAAFLIKNPATHKELSI 624
Query: 347 VVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAH 405
V L+ ++ Q+ASG+ Y+ S+ F+HRDLA RNCLVG+ +VK+ DFG++R + D Y
Sbjct: 625 VELLQISVQVASGVEYMASQHFVHRDLATRNCLVGDKLVVKIGDFGMSRDIYSTDYYRVG 684
Query: 406 AGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
P++W PE + Y F+ +SD+W+FG++LWEI T+G P+
Sbjct: 685 GHTMLPVRWMPPESVLYRKFTIESDIWSFGVVLWEIFTFGKQPW 728
>UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 1462
Score = 160 bits (389), Expect = 6e-38
Identities = 94/232 (40%), Positives = 133/232 (57%), Gaps = 15/232 (6%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW-------KRGNITVAVKTLK--DDTM--ALKDFLE 293
+ +++ + LG G +G V +A W ++ I VAVKTLK +D + A + ++
Sbjct: 830 VKESELEFRKMLGSGAFGTVQKAIWTPLNIQGEKVKIAVAVKTLKTSEDLLQSANNEIMD 889
Query: 294 EASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR-AGARECVPGAVVLMYM 352
EA +M + P LV+LLG+ E +IT+ M G+LLEY+R R+ + +L +
Sbjct: 890 EAYMMASVECPYLVRLLGISMTEQ-VALITQLMPLGSLLEYVRNPTTRDSIRSRQILSW- 947
Query: 353 ATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-GAKFP 411
QIA GM YLE + +HRDLAARN LV + VK+ DFGLA+++ HA G K P
Sbjct: 948 CVQIAKGMKYLEEKHLVHRDLAARNVLVKTPNHVKITDFGLAKMLDTKEEIYHAEGGKLP 1007
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
IKW A E + FS SDVWAFG+ WE+ T+G PY GV DV +LE+
Sbjct: 1008 IKWLAIECITEREFSHLSDVWAFGVTCWELLTFGARPYEGVRAVDVLSLLER 1059
>UniRef50_Q19726 Cluster: Putative uncharacterized protein kin-14;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein kin-14 - Caenorhabditis elegans
Length = 418
Score = 160 bits (389), Expect = 6e-38
Identities = 108/341 (31%), Positives = 177/341 (51%), Gaps = 38/341 (11%)
Query: 132 EKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRS--ISLRYEGRVYHYRINEDA 189
+ + W+HG + R A+ LL GSFL+R SE G+ S +S+R++G++++ +N D
Sbjct: 26 QNNEWFHGVLQRQDADELLVKP--GSFLLRASEVH-GKMSMILSVRHDGKLHNIAVNSDT 82
Query: 190 DGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTV-FPLAPPDHWEIDRT 248
G+ + + ++ +LV H P K S + +P+ D W I
Sbjct: 83 -GENFWFEGHREKSIDQLVQWHMTTST--------PITKTSGVKLKYPIGKAD-WIISHE 132
Query: 249 DIVMKHKLGGGQYGDVYEAAWKRGN--ITVAVKTLK----DDTMALKDFLEEASIMKEMR 302
+++ KLG G +G+V A + G + AVKT++ DT A F++EA +M++
Sbjct: 133 NVIFIKKLGEGAFGEVSLAECEIGGRKVETAVKTMRCQMTRDTRAA--FMKEARLMRKYS 190
Query: 303 HPNLVQLLG-----------VCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMY 351
HP++V+++G + P I+ E G+LL +LR + +
Sbjct: 191 HPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSE--RLR 248
Query: 352 MATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFP 411
+ A G++YLE + +HRD+AARNCL+ +K++DFGL+ R + + K P
Sbjct: 249 FCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTEMHDDTLD-KVP 307
Query: 412 IKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
+KW APE + +S KSDVWAFG+L+WEI G PYPG+
Sbjct: 308 VKWLAPEVMQDKLYSLKSDVWAFGVLMWEIYADGADPYPGM 348
>UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG18247-PA - Tribolium castaneum
Length = 725
Score = 160 bits (388), Expect = 8e-38
Identities = 82/217 (37%), Positives = 131/217 (60%), Gaps = 8/217 (3%)
Query: 252 MKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMALKD-FLEEASIMKEMRHPNLV 307
M +G G++G VYE + + N I VA+KT++ + + + L+EA +M + H +V
Sbjct: 452 MGRVIGEGEFGSVYEGTYTKRNGEEIKVAIKTVRHEQIETSNAILKEAHVMMRLNHHCVV 511
Query: 308 QLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRS 367
+L+G+ ++ P ++ E ++ G++L Y+ P + ++ A QIA GM+YLE +
Sbjct: 512 KLIGL-SKGRPLLMVQELVALGSMLNYIILNKESINPNSEFKIW-AAQIACGMNYLEEQR 569
Query: 368 FIHRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNTF 425
FIHRDLAARN L+ H K++DFGL+R + D Y A G K+P+KW APE Y F
Sbjct: 570 FIHRDLAARNILLASQHQAKISDFGLSRALAADHEYYRALQGGKWPLKWYAPESYNYGQF 629
Query: 426 STKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
S KSDVW+FG+ +WE+ ++G PY + +D ++E
Sbjct: 630 SHKSDVWSFGVAIWEMYSFGDVPYGELKGSDAIKIIE 666
Score = 60.1 bits (139), Expect = 1e-07
Identities = 36/114 (31%), Positives = 59/114 (51%), Gaps = 4/114 (3%)
Query: 123 NYVTPVNSLEKHSWYHGPISRNAAEYLLS--SGINGSFLVRESESSPGQRSISLRYEGRV 180
NY P + WYHG + R+ AE + S +G+FLVR S+ + +R ++L E
Sbjct: 273 NYQCPAPKTHRSYWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESLF 331
Query: 181 YHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTV 234
Y+Y I + D +++ + +L ++ ++S DGL T L P P + KP V
Sbjct: 332 YNYIIRKQ-DDYLFIDNGPYLESLEHIIEYYSFIPDGLPTVLQTPVPPKPKPPV 384
Score = 55.2 bits (127), Expect = 4e-06
Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Query: 136 WYHGPISRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKV 193
WYHG +SR A E LL +GSFLVRES SS G +S+ + V H++I ++
Sbjct: 9 WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHSEDAF 68
Query: 194 Y-VTSESKFGTLAELVHHHSVAGDGLITQ 221
+ + +K L L+ H+ V G++++
Sbjct: 69 FSIDENTKIHGLESLIEHY-VNTKGILSE 96
>UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome
shotgun sequence; n=3; Fungi/Metazoa group|Rep:
Chromosome 3 SCAF14978, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 958
Score = 160 bits (388), Expect = 8e-38
Identities = 82/226 (36%), Positives = 133/226 (58%), Gaps = 7/226 (3%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRG---NITVAVKTLKDDTMALKD-FLEEAS 296
+ ++I R DI++ LG G +G+V+ +K N++VA+KT K+ + +K+ FL EAS
Sbjct: 378 EKYKISRDDIIVGQILGEGFFGEVHNGVYKTQTGENLSVAIKTCKNCSADVKEKFLSEAS 437
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
+MK + HP++V+L+GV +P +I+ E G L +YL V+L+ QI
Sbjct: 438 VMKNLDHPHIVRLIGVIEADP-VWIVMELYEHGELGKYLVEQQYSLT--TVMLITYCLQI 494
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTA 416
++YLE + +HRD+A RN LV VK+ DFGL+R + ++ Y + ++ PIKW A
Sbjct: 495 CKALAYLEGLNVVHRDIAVRNILVASPLCVKLGDFGLSRYIEEEEYYKASASRLPIKWMA 554
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
PE + + F+T SDVW FG+ +WEI + P+ ++ + V LE
Sbjct: 555 PESINFRRFTTASDVWMFGVCVWEIFSMAQQPFFWLENSQVIDQLE 600
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 295
Score = 160 bits (388), Expect = 8e-38
Identities = 99/243 (40%), Positives = 135/243 (55%), Gaps = 23/243 (9%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKR-----GNITVAVKTLK--DDTMALKDFLEEA 295
WE R + LG G +G V +A + G++ VAVK +K D A +D + E
Sbjct: 2 WEFPRDRVKTSVVLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMAEL 61
Query: 296 SIMKEMR-HPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR--AGARE-------CVPG 345
++K + HPN++ LLG CTR P +I EF G+L YLR G + VP
Sbjct: 62 DLLKLIDPHPNVIGLLGCCTRGDPLMVIVEFCQYGDLQSYLRHCRGIEDKYYEQIYMVPE 121
Query: 346 ----AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDD 400
A L+ Q A GM++L S +HRDLAARN L+ E + KV+DFG AR + +D
Sbjct: 122 KKLTAKDLLSFGIQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFARDIYVED 181
Query: 401 TYTAHA-GAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYH 459
YT G +FPIKW A E L +TKSDVW++G+LLWEI T G SPYPG++ +V +
Sbjct: 182 HYTRKTQGGRFPIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQEVIN 241
Query: 460 MLE 462
L+
Sbjct: 242 FLQ 244
>UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR1 precursor; n=21; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR1
precursor - Homo sapiens (Human)
Length = 937
Score = 160 bits (388), Expect = 8e-38
Identities = 84/210 (40%), Positives = 126/210 (60%), Gaps = 17/210 (8%)
Query: 276 VAVKTLKD--DTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLE 333
VA+KTLKD + +F +EAS+M E+ HPN+V LLG T+E P ++ E++++G+L E
Sbjct: 503 VAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHE 562
Query: 334 YL-------RAGARECVPGAVV-------LMYMATQIASGMSYLESRSFIHRDLAARNCL 379
+L G G V +++A QIA+GM YL S F+H+DLAARN L
Sbjct: 563 FLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNIL 622
Query: 380 VGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILL 438
+GE VK++D GL+R + D Y + + PI+W PE + Y FS+ SD+W+FG++L
Sbjct: 623 IGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVL 682
Query: 439 WEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
WEI ++G+ PY G +V M+ K + P
Sbjct: 683 WEIFSFGLQPYYGFSNQEVIEMVRKRQLLP 712
>UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2
precursor; n=36; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-2 precursor - Homo sapiens
(Human)
Length = 1255
Score = 160 bits (388), Expect = 8e-38
Identities = 89/231 (38%), Positives = 132/231 (57%), Gaps = 10/231 (4%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW----KRGNITVAVKTLKDDTM--ALKDFLEEASIM 298
+ T++ LG G +G VY+ W + I VA+K L+++T A K+ L+EA +M
Sbjct: 715 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 774
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIAS 358
+ P + +LLG+C ++T+ M G LL+++R G+ L+ QIA
Sbjct: 775 AGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRL--GSQDLLNWCMQIAK 831
Query: 359 GMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHA-GAKFPIKWTAP 417
GMSYLE +HRDLAARN LV + VK+ DFGLARL+ D HA G K PIKW A
Sbjct: 832 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMAL 891
Query: 418 EGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
E + F+ +SDVW++G+ +WE+ T+G PY G+ ++ +LEK + P
Sbjct: 892 ESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLP 942
>UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC
2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein
2).; n=3; Deuterostomia|Rep: Activated CDC42 kinase 1
(EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor
protein 2). - Takifugu rubripes
Length = 1127
Score = 159 bits (387), Expect = 1e-37
Identities = 89/228 (39%), Positives = 123/228 (53%), Gaps = 10/228 (4%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAW--KRGNI-TVAVKTLKDDTM----ALKDFLEEASI 297
I D+ + KLG G +G V W G + VAVK LK D + AL+DF+ E +
Sbjct: 133 IPEKDLTLFEKLGDGSFGVVKRGEWLTPTGKVLNVAVKCLKTDVLSQPDALEDFICEVNA 192
Query: 298 MKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIA 357
M + H NL++L GV P ++TE G+LLE LR + L A Q++
Sbjct: 193 MHSLDHQNLIRLYGVVLTHP-MKMVTELAPLGSLLERLRCVHPQGPVLIHTLCQYAVQVS 251
Query: 358 SGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWT 415
GM+YLE R FIHRDLAARN L+ H +K+ DFGL R + + Y K P W
Sbjct: 252 CGMAYLEQRRFIHRDLAARNILLASAHKIKIGDFGLMRALPNNHEHYVMQEHRKVPFAWC 311
Query: 416 APEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L TFS +D W FG+ LWE+ T+G P+ G++ + + H ++K
Sbjct: 312 APESLKTRTFSHATDTWMFGVTLWEMFTHGQEPWLGLNGSQILHKIDK 359
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 159 bits (387), Expect = 1e-37
Identities = 88/222 (39%), Positives = 127/222 (57%), Gaps = 11/222 (4%)
Query: 256 LGGGQYGDVYEAAW---KRGNITVAVKTLK--DDTMALKDFLEEASIMKEMRHPNLVQLL 310
+G G +G VY + + I AVK+L + + FL E +M+ + HPN++ L+
Sbjct: 686 IGKGHFGVVYHGEYIDEDQNRIHCAVKSLSRITEVQEAEAFLREGLLMRGLHHPNVLALI 745
Query: 311 G-VCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
G V E ++ +M G+LL ++R+ R P L+ Q+A GM YL + F+
Sbjct: 746 GIVLPPEGLPRVLLPYMRHGDLLRFIRSPQRN--PTVKDLISFGLQVARGMEYLAEQKFV 803
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNTFS 426
HRDLAARNC++ E+ VKVADFGLAR + D Y + H A+ P+KW A E L F+
Sbjct: 804 HRDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRHARLPVKWMALESLQTYRFT 863
Query: 427 TKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAP 468
TKSDVW+FG+LLWE+ T G PYP +D D+ L + + P
Sbjct: 864 TKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRLP 905
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 159 bits (387), Expect = 1e-37
Identities = 89/230 (38%), Positives = 125/230 (54%), Gaps = 20/230 (8%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWK----RGNITVAVKTLKDDTMA--LKDFLEEASIM 298
+D+ + LG G +G+VYE K VA+KTLK ++FL+EA +M
Sbjct: 446 LDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLM 505
Query: 299 KEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVV------LMYM 352
+H ++ +LLGVC II E M G+LL YL A + +PG L+ M
Sbjct: 506 SNFKHKHITRLLGVCLEADALLIIMELMQGGDLLSYLPA---QPLPGQAARLTMLDLISM 562
Query: 353 ATQIASGMSYLESRSFIHRDLAARNCLVGE----NHLVKVADFGLAR-LMRDDTYTAHAG 407
+ASG YLE F+HRDLA RNCLV + +VK+ DFGLAR + ++D Y
Sbjct: 563 CQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGE 622
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
P++W +PE L F+++SD+WAFG+LLWEI T G PY + +V
Sbjct: 623 GLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEV 672
>UniRef50_Q18865 Cluster: Putative uncharacterized protein; n=5;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 431
Score = 159 bits (386), Expect = 1e-37
Identities = 111/336 (33%), Positives = 172/336 (51%), Gaps = 30/336 (8%)
Query: 136 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ-RSISLRYEGR----VYHYRINEDAD 190
+YHG + R + +L+ G FL+R SE G+ R L G H+ + E AD
Sbjct: 11 YYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKNTSANHFVVRE-AD 67
Query: 191 GKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDI 250
KVYV + F T+ ELV+H+ + T+ K + WE+ D+
Sbjct: 68 HKVYV-DKIGFPTIIELVNHYVSTKESFSTK-----DGTVKVVLKHAVERQKWELYHEDV 121
Query: 251 VMKHKLGGGQYGDVYEAAWKR---GN---ITVAVKTLKDDTMA---LKDFLEEASIMKEM 301
+ KLG G +G+V++ + N + VAVKT K ++M +K+ + EA +M+ +
Sbjct: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
Query: 302 RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMS 361
H N+V+ GV P Y+I E ++ G L+ + L+Y A A+G++
Sbjct: 182 DHINVVKFFGVAAGTEPLYVIME-LADGGALDSALGKLHFPMIKKYELIYQA---ANGLA 237
Query: 362 YLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLA 421
Y+ ++ +HRD+AARNCL G VK+ADFGL+R D YT K PI+W PE +
Sbjct: 238 YIHEKNLMHRDVAARNCLYGGGQ-VKIADFGLSREGAD--YTMDLKKKVPIRWLPPETIR 294
Query: 422 YNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
++ K+DV+AFG++ WEI G PYPG + +V
Sbjct: 295 SGLYTPKTDVFAFGVMAWEITEDGKEPYPGFKVIEV 330
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 159 bits (386), Expect = 1e-37
Identities = 97/247 (39%), Positives = 140/247 (56%), Gaps = 25/247 (10%)
Query: 242 HWEIDRTDIVMKHKLGGGQYGDVYEAAWK-----RGNITVAVKTLKDD-TMA-LKDFLEE 294
+WE R+ +V+ LG G +G V A + + VAVK LK+ T A +KD + E
Sbjct: 618 NWEFPRSKLVLGKSLGEGAFGKVVMAEANGLVKGQASTVVAVKMLKEGHTDADVKDLVCE 677
Query: 295 ASIMKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLR------AGARECVPG-- 345
+MK + +H N++ LLG C ++ P Y+I E+ GNL ++LR A + + G
Sbjct: 678 MEVMKMIGKHVNIINLLGCCCKDGPLYVIVEYAPHGNLKDFLRSHRFGTANYEDMISGEK 737
Query: 346 ------AVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMR 398
L+ A QIA GM +L SR IHRDLAARN LV + +++K+ADFGLAR +
Sbjct: 738 EKKILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIHS 797
Query: 399 DDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVY 458
+ Y K PI+W APE L + ++SDVW+FG+LLWEI T G +PY + D
Sbjct: 798 QEYYRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYSSIPTWD-- 855
Query: 459 HMLEKVK 465
++LE +K
Sbjct: 856 NLLEHLK 862
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 159 bits (385), Expect = 2e-37
Identities = 82/199 (41%), Positives = 118/199 (59%), Gaps = 6/199 (3%)
Query: 274 ITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPF-YIITEFMSRGNLL 332
I V+V + D ++ FL+E IMK H N++ LLG+ + ++ +M G+L
Sbjct: 1120 IFVSVSSGITDAEEVEQFLKEGIIMKGFHHCNVLSLLGILLPQEGLPLVVLPYMKHGDLR 1179
Query: 333 EYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
++R R P L+ Q+A+GM YL + F+HRDLAARNC++ E++ VKVADFG
Sbjct: 1180 HFIRCEKRN--PTVKDLIGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFG 1237
Query: 393 LARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPY 449
+AR + D Y + H AK P+KW A E L F+ KSDVW+FG+L+WE+ T G SPY
Sbjct: 1238 MARDVLDKEYYSVQNHRKAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPY 1297
Query: 450 PGVDLADVYHMLEKVKFAP 468
P VD D+ H L + + P
Sbjct: 1298 PDVDPYDITHYLLRGRRLP 1316
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 159 bits (385), Expect = 2e-37
Identities = 92/215 (42%), Positives = 127/215 (59%), Gaps = 12/215 (5%)
Query: 256 LGGGQYGDVYEAAW----KRGNITVAVKTLKDDTMA--LKDFLEEASIMKEMRHPNLVQL 309
LG G +G VY+ W + I VA+K L T A ++FL EA IM ++L
Sbjct: 843 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMAXXXXXXXLKL 902
Query: 310 LGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFI 369
L VC +IT+ M G LL+Y+R R+ + G+ L+ +TQIA GMSYLE + +
Sbjct: 903 LAVCMSSQ-MMLITQLMPLGCLLDYVRNN-RDKI-GSKALLNWSTQIAKGMSYLEEKRLV 959
Query: 370 HRDLAARNCLVGENHLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNTFST 427
HRDLAARN LV LVK+ DFGLA+L+ D+ Y A AG K PIKW A E + F++
Sbjct: 960 HRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTS 1018
Query: 428 KSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLE 462
KSDVWAFG+ +WE+ T+G P+ + D+ ++E
Sbjct: 1019 KSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1053
>UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing
receptor 1 precursor; n=40; Mammalia|Rep: Epithelial
discoidin domain-containing receptor 1 precursor - Homo
sapiens (Human)
Length = 913
Score = 159 bits (385), Expect = 2e-37
Identities = 94/237 (39%), Positives = 135/237 (56%), Gaps = 35/237 (14%)
Query: 240 PDHWEIDRTDIVMKHKLGGGQYGDV---------------YEAAWKRGN-ITVAVKTLKD 283
P + R+ + K KLG GQ+G+V + ++G+ + VAVK L+
Sbjct: 600 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 659
Query: 284 DTM--ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAG--- 338
D A DFL+E IM ++ PN+++LLGVC ++ P +IT++M G+L ++L A
Sbjct: 660 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 719
Query: 339 --ARECVPGA-----------VVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHL 385
A E PG +L+++A QIASGM YL + +F+HRDLA RNCLVGEN
Sbjct: 720 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 779
Query: 386 VKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEI 441
+K+ADFG++R L D Y A PI+W A E + F+T SDVWAFG+ LWE+
Sbjct: 780 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 836
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 158 bits (384), Expect = 3e-37
Identities = 92/228 (40%), Positives = 132/228 (57%), Gaps = 16/228 (7%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAW-KRGN---ITVAVKTLKDD-TMALKD-FLEE 294
D WE+ R I+ +LG G +G VY+ K GN + A+KT+ ++ T +D FL E
Sbjct: 984 DEWEVPREHIIQLEELGQGSFGMVYKGIMTKLGNDVNVPCAIKTVTENATERERDSFLIE 1043
Query: 295 ASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA------GARECVPGAVV 348
A+IMKE ++V+L GV + P +I E M+ G+L YLR E P
Sbjct: 1044 ATIMKEFHTHHVVRLYGVVSVGQPTLVIMELMANGDLKSYLRRHRPDYENGEESSPQPPT 1103
Query: 349 L--MY-MATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTA 404
L +Y MA +IA GM+YL ++ F+HRDLAARNC+V E+ VK+ DFG+ R + D Y
Sbjct: 1104 LKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRK 1163
Query: 405 HAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
P++W APE L FS+ SDV+++G++LWE+AT PY G+
Sbjct: 1164 GTKGFLPVRWMAPESLKDGMFSSSSDVFSYGVVLWEMATLASQPYQGL 1211
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 158 bits (383), Expect = 3e-37
Identities = 90/224 (40%), Positives = 126/224 (56%), Gaps = 13/224 (5%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWK-RGNIT--VAVKTLKDDT--MALKDFLEEA 295
D +I R I + LG G +G+V++ ++ R N VAVK + + DF+ EA
Sbjct: 879 DLTQIPRECITLIRPLGQGAFGEVFQGVYRYRRNQEQPVAVKAIPSSSRPQTEADFMMEA 938
Query: 296 SIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGA-RECVPGAVV---LMY 351
IM + HPN+V +GV P YI+ E ++ GNL +LR R P ++ L+
Sbjct: 939 LIMSKFNHPNIVHFIGVSFERNPKYIVLELLAGGNLKNFLREERPRADRPTSLRMQDLIM 998
Query: 352 MATQIASGMSYLESRSFIHRDLAARNCLV---GENHLVKVADFGLAR-LMRDDTYTAHAG 407
+A+G Y+E FIHRD+AARNCL+ G +VK+ADFG+A+ + R D Y
Sbjct: 999 CGFDVANGCKYMEEARFIHRDIAARNCLLTSKGPGRIVKIADFGMAKDIYRSDYYRKGGK 1058
Query: 408 AKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
A PIKW PE F+TK+DVWAFG+LLWEI ++G PY G
Sbjct: 1059 AMLPIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYIPYTG 1102
>UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4;
Caenorhabditis|Rep: Isoform b of Q10656 - Caenorhabditis
elegans
Length = 988
Score = 158 bits (383), Expect = 3e-37
Identities = 93/257 (36%), Positives = 142/257 (55%), Gaps = 36/257 (14%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKR---GNITVAVKTLKDDT--MALKDFLEEASI 297
WE++R+ + + H LG G +G+V++A +K I VAVK LK L D + E
Sbjct: 581 WEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMET 640
Query: 298 MKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGN---------------------LLEYL 335
K + H N+++L+G CT P Y++ E GN L +YL
Sbjct: 641 FKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYL 700
Query: 336 ---RAGAR---ECVPGAVV--LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVK 387
+A + E +P L+ A Q+A GM++L S+ IHRDLAARN LVG+ H++K
Sbjct: 701 EPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLK 760
Query: 388 VADFGLARLMR-DDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGM 446
++DFGL+R + +D Y + PIKW A E L N ++ +SDVW++G+LLWEI T G
Sbjct: 761 ISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGG 820
Query: 447 SPYPGVDLADVYHMLEK 463
+PYP + + ++Y L++
Sbjct: 821 TPYPTIAMPELYANLKE 837
>UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep:
CG14992-PA - Drosophila melanogaster (Fruit fly)
Length = 1073
Score = 158 bits (383), Expect = 3e-37
Identities = 86/229 (37%), Positives = 120/229 (52%), Gaps = 13/229 (5%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN----ITVAVKTLKDDTMA----LKDFLEEAS 296
I DI M KLG G +G V W I VAVK LK D + + DF E
Sbjct: 118 IHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQ 177
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
M + H NLV+L GV +P +ITE RG+LL+ LR R ++ + QI
Sbjct: 178 AMHALDHANLVRLYGVVLSQP-MMMITELAERGSLLDTLRKQCRHT--SLTIIWNWSVQI 234
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKW 414
+GM+YLE + F+HRDLA RN L+ + +K+ DFGL R + DD Y K P W
Sbjct: 235 VTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPW 294
Query: 415 TAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
APE L + FS SD W FG+ LWE+ ++G P+ G++ + + +++
Sbjct: 295 CAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDR 343
>UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56;
n=15; Sophophora|Rep: Focal adhesion kinase homolog
DFak56 - Drosophila melanogaster (Fruit fly)
Length = 1200
Score = 158 bits (383), Expect = 3e-37
Identities = 94/257 (36%), Positives = 140/257 (54%), Gaps = 33/257 (12%)
Query: 242 HWEIDRTDIVMKHKLGGGQYGDVYEAAW---------------KRGN------------I 274
++E+DR+ I K+G GQ+GDVY + K N I
Sbjct: 449 NYELDRSLITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVI 508
Query: 275 TVAVKTLK--DDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLL 332
VA+KT K DD ++FL EA IM++ HP++++L+G+C+ P +I+ E G L
Sbjct: 509 QVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICS-VMPIWIVMELAKLGELR 567
Query: 333 EYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFG 392
YL+ + G L+ Q+++ +SYLES+ F+HRD+AARN LV VK+ADFG
Sbjct: 568 AYLKTNSERLSHGT--LLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFG 625
Query: 393 LARLMRDDTYT-AHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPG 451
L+R + D +Y + PIKW +PE + + F+T SDVW FG+ +WEI G+ P+ G
Sbjct: 626 LSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQG 685
Query: 452 VDLADVYHMLEKVKFAP 468
V +DV LE + P
Sbjct: 686 VKNSDVILKLENGERLP 702
>UniRef50_Q22765 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 546
Score = 158 bits (383), Expect = 3e-37
Identities = 113/353 (32%), Positives = 167/353 (47%), Gaps = 25/353 (7%)
Query: 131 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ---RSISLRYEGRVYHYRINE 187
L +YHG + R Y+L G F+ R +E + G+ + I L + +
Sbjct: 11 LMNQKFYHGYLPREDLPYVLKK--KGDFIFRVTERTVGKEQKKDIVLSIAWPTESVAMID 68
Query: 188 DADGKVYVTSESKFGTLAEL-VHHHSVAGDGLITQLLYPAPKRSKPTV-FPLAPPD---H 242
D K Y+ S +L + HS+ D L Y + P + L P
Sbjct: 69 TKDIKNYLIERSANSVWLDLKISFHSI--DALYNH--YRKNELVHPNLRIKLGRPICLFF 124
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITV--AVKTLKDDTMA----LKDFLEEAS 296
WE + I + K+G G YG+V++ RGN T A+K ++ D A +K+ + EA
Sbjct: 125 WEFKHSQINLIKKVGKGAYGEVFKGTVTRGNKTFNGAIKAMRKDLDAGNEKMKEVMAEAR 184
Query: 297 IMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQI 356
+M+ + HPN+V+ G+ E P YI+ EF++ G L YL+ ++ MA
Sbjct: 185 LMRSLNHPNIVRCRGIAVLEQPVYIVIEFINGGGLDSYLKKNSQTLTMDQK--NRMAISA 242
Query: 357 ASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTA 416
A G+ ++ S IHRD+AARNCL +LVK++DFGL+R + Y K P KW A
Sbjct: 243 AWGIEFMHSHDIIHRDIAARNCLYDNKNLVKLSDFGLSR--KGSVYRMKKAMKMPTKWLA 300
Query: 417 PEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKVKFAPF 469
PE L TFS SDV+ FG+LL+EI T PY V + + F F
Sbjct: 301 PESLTTFTFSGASDVYTFGVLLYEIYTC-QEPYLAVKAGEAKRYILSGAFPNF 352
>UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15
precursor; n=7; Caenorhabditis elegans|Rep: Myoblast
growth factor receptor egl-15 precursor - Caenorhabditis
elegans
Length = 1040
Score = 158 bits (383), Expect = 3e-37
Identities = 93/257 (36%), Positives = 142/257 (55%), Gaps = 36/257 (14%)
Query: 243 WEIDRTDIVMKHKLGGGQYGDVYEAAWKR---GNITVAVKTLKDDT--MALKDFLEEASI 297
WE++R+ + + H LG G +G+V++A +K I VAVK LK L D + E
Sbjct: 633 WEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMET 692
Query: 298 MKEM-RHPNLVQLLGVCTREPPFYIITEFMSRGN---------------------LLEYL 335
K + H N+++L+G CT P Y++ E GN L +YL
Sbjct: 693 FKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYL 752
Query: 336 ---RAGAR---ECVPGAVV--LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVK 387
+A + E +P L+ A Q+A GM++L S+ IHRDLAARN LVG+ H++K
Sbjct: 753 EPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLK 812
Query: 388 VADFGLARLMR-DDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGM 446
++DFGL+R + +D Y + PIKW A E L N ++ +SDVW++G+LLWEI T G
Sbjct: 813 ISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGG 872
Query: 447 SPYPGVDLADVYHMLEK 463
+PYP + + ++Y L++
Sbjct: 873 TPYPTIAMPELYANLKE 889
>UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2
precursor; n=54; Euteleostomi|Rep: Discoidin
domain-containing receptor 2 precursor - Homo sapiens
(Human)
Length = 855
Score = 158 bits (383), Expect = 3e-37
Identities = 93/227 (40%), Positives = 127/227 (55%), Gaps = 26/227 (11%)
Query: 244 EIDRTDIVMKHKLGGGQYGDVY----EAAWKRGN------------ITVAVKTLKDDTM- 286
E R + K KLG GQ+G+V+ E K + + VAVK L+ D
Sbjct: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616
Query: 287 -ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPG 345
A DFL+E IM ++ PN++ LL VC + P +ITE+M G+L ++L
Sbjct: 617 NARNDFLKEIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676
Query: 346 AVV-------LMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLAR-LM 397
+ V L +MATQIASGM YL S +F+HRDLA RNCLVG+N+ +K+ADFG++R L
Sbjct: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736
Query: 398 RDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATY 444
D Y A PI+W + E + F+T SDVWAFG+ LWE T+
Sbjct: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTF 783
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 157 bits (382), Expect = 4e-37
Identities = 89/227 (39%), Positives = 130/227 (57%), Gaps = 13/227 (5%)
Query: 242 HWEIDRTDIVM--KHKLGGGQYGDVYEAAWKRGNIT---VAVKTLK--DDTMALKDFLEE 294
H I R D+++ +G G +G V+ + A+K+L D + FL+E
Sbjct: 1069 HVVIAREDLLLHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKE 1128
Query: 295 ASIMKEMRHPNLVQLLGVCT-REPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMA 353
I+K+ HPN++ LLG+C E ++ +M G+L ++R + P LM
Sbjct: 1129 GIIVKDFSHPNVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHN--PTVKDLMGFG 1186
Query: 354 TQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD-DTYTAH--AGAKF 410
Q+A GM YL S+ F+HRDLAARNC++ E++ VKVAD GLAR + D + Y+ H G K
Sbjct: 1187 LQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARDVYDKEYYSVHNKHGVKL 1246
Query: 411 PIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADV 457
P+KW A E L + F+TKSDVW+FG+LLWE+ T G PY V+ D+
Sbjct: 1247 PVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDI 1293
>UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep:
Zgc:154019 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 732
Score = 157 bits (382), Expect = 4e-37
Identities = 90/224 (40%), Positives = 128/224 (57%), Gaps = 8/224 (3%)
Query: 245 IDRTDIVMKHKLGGGQYGDVYEAAWKRGN---ITVAVKTLKDDTMAL-KDFLEEASIMKE 300
I +++ +LG G +G V +A W + VAVKTL+ + L DFL+E + M+
Sbjct: 106 IQDRELLFGDRLGSGSFGVVRKAEWHTPTGRVLPVAVKTLRSGQVDLVSDFLQEVTSMQS 165
Query: 301 MRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGM 360
+ HPN++ L GV P ++TE G+L + LR E P + + ++ +TQIA+GM
Sbjct: 166 LDHPNIIHLYGVVLTHP-LKMVTELAPLGSLYDTLRLRHGE-YPLSRLWLF-STQIAAGM 222
Query: 361 SYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAPEG 419
YLESR FIHRDLAARN L+ VK+ DFGL R + D D Y A + P W APE
Sbjct: 223 EYLESRRFIHRDLAARNVLLAAREQVKIGDFGLMRGLDDRDHYIMTAHRRIPFAWCAPES 282
Query: 420 LAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEK 463
L +FS SDVW FG+ LWE+ TY P+ G+ + + +E+
Sbjct: 283 LRTGSFSHASDVWMFGVTLWEMFTYCEEPWLGLSGRQILYRVER 326
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 157 bits (382), Expect = 4e-37
Identities = 90/249 (36%), Positives = 130/249 (52%), Gaps = 28/249 (11%)
Query: 241 DHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKE 300
D WE+D + LG G +G V ++ + + + +D + E ++MK
Sbjct: 577 DEWELDPHSLKFSTLLGQGAFGKVVTGYYEDQKVAIKIVREGAPLSYKEDLVAEINLMKR 636
Query: 301 M-RHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRA---------------------- 337
+ HPN+V L+G CT P ++ E++ GNL +L+
Sbjct: 637 IGSHPNIVCLIGACTMSEPIALVMEYVPYGNLQNFLKKCRMDGDVRKRCDGPSEITYTVI 696
Query: 338 ---GAREC-VPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGL 393
G+ E V V ++ A Q+A M YL + ++HRDLAARN L+ N +VKV DFGL
Sbjct: 697 QDNGSMESGVVTPVDMLSFARQVAMAMEYLAEKKYVHRDLAARNVLIDYNKVVKVCDFGL 756
Query: 394 AR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGV 452
+R + D+ Y K P+KW A E L F+T+SDVW+FGILLWEI T G SPYP V
Sbjct: 757 SRDIFNDNHYKKLTNGKLPLKWMAIESLRDRMFTTQSDVWSFGILLWEIVTMGASPYPNV 816
Query: 453 DLADVYHML 461
LAD+Y++L
Sbjct: 817 ALADLYYVL 825
>UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona
intestinalis|Rep: Discoidin receptor - Ciona
intestinalis (Transparent sea squirt)
Length = 457
Score = 157 bits (382), Expect = 4e-37
Identities = 81/185 (43%), Positives = 112/185 (60%), Gaps = 14/185 (7%)
Query: 274 ITVAVKTLKDDTM--ALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNL 331
+ VAVK L+ D A +DFL+E +M +M+ PN+V L+ VCT + P+ +ITE+M G+L
Sbjct: 180 VLVAVKVLRADATSNAKEDFLKEVRVMSQMQDPNIVHLIAVCTNDEPYAMITEYMENGDL 239
Query: 332 LEYLRAGA-----------RECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLV 380
+YLR+ A VL+ M QIASGM YL S F+HRDLA RNCLV
Sbjct: 240 NQYLRSCADKMNSDPSSKENSLFSSNEVLINMCVQIASGMRYLSSHKFVHRDLATRNCLV 299
Query: 381 GENHLVKVADFGLARLM-RDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLW 439
NH +++ADFG++R M + D Y A PI+W + E + FS+ SD WAFG+ LW
Sbjct: 300 DSNHSIRIADFGMSRNMYQSDYYRIQGRAVLPIRWMSWECVLMGKFSSASDAWAFGVTLW 359
Query: 440 EIATY 444
EI ++
Sbjct: 360 EIFSF 364
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.320 0.135 0.416
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 524,149,785
Number of Sequences: 1657284
Number of extensions: 21554372
Number of successful extensions: 72586
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 5941
Number of HSP's successfully gapped in prelim test: 5082
Number of HSP's that attempted gapping in prelim test: 50566
Number of HSP's gapped (non-prelim): 13589
length of query: 473
length of database: 575,637,011
effective HSP length: 104
effective length of query: 369
effective length of database: 403,279,475
effective search space: 148810126275
effective search space used: 148810126275
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 74 (33.9 bits)
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