Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002066-TA|BGIBMGA002066-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(731 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB... 376 e-102
UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|... 341 4e-92
UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila melanogaster|... 299 2e-79
UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome sh... 265 3e-69
UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC 4.6... 262 2e-68
UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41; Deutero... 260 7e-68
UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome s... 254 8e-66
UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella ve... 242 3e-62
UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebr... 237 6e-61
UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia califor... 228 5e-58
UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome sh... 215 4e-54
UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1) (... 206 2e-51
UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:... 196 2e-48
UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC 4.6... 195 3e-48
UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate ... 194 7e-48
UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC 4.6... 192 2e-47
UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC 4.6... 192 2e-47
UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1) (... 192 2e-47
UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain aden... 191 5e-47
UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl c... 185 4e-45
UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA... 185 4e-45
UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep: ... 185 4e-45
UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome sho... 182 3e-44
UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2; Caenor... 182 3e-44
UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome s... 180 2e-43
UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gamb... 176 2e-42
UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC 4.6... 175 5e-42
UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2; Caenor... 174 6e-42
UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73; Euteleo... 174 8e-42
UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate ... 173 1e-41
UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|R... 172 2e-41
UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole... 171 4e-41
UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate ... 171 6e-41
UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to ENSANGP000... 166 2e-39
UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl c... 165 3e-39
UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29; Euteleo... 165 5e-39
UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate ... 164 7e-39
UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whol... 161 5e-38
UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 161 6e-38
UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia califor... 160 1e-37
UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2; Sophopho... 160 1e-37
UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 159 2e-37
UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|... 159 2e-37
UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG571... 159 3e-37
UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6... 155 4e-36
UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|R... 153 1e-35
UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl c... 152 3e-35
UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate ... 151 9e-35
UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora... 150 1e-34
UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2; Apoc... 149 3e-34
UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7; D... 146 1e-33
UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep: ... 141 5e-32
UniRef50_UPI000155633D Cluster: PREDICTED: hypothetical protein,... 136 2e-30
UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella ve... 133 2e-29
UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whol... 128 5e-28
UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|... 126 3e-27
UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila melanogaste... 111 6e-23
UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep: ... 110 1e-22
UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4; Sop... 106 2e-21
UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:... 105 4e-21
UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 103 2e-20
UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,... 101 9e-20
UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 101 9e-20
UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1;... 100 1e-19
UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; ... 97 1e-18
UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmo... 97 2e-18
UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella ve... 96 3e-18
UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalyt... 96 3e-18
UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 95 5e-18
UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 95 6e-18
UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl c... 95 8e-18
UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 93 2e-17
UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate ... 92 4e-17
UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 92 4e-17
UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p... 92 6e-17
UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; ... 91 1e-16
UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1; L... 91 1e-16
UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4; Burkh... 90 2e-16
UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|R... 90 2e-16
UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3; Oscillatoriales... 89 3e-16
UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 89 3e-16
UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|... 89 4e-16
UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalyt... 89 4e-16
UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella ve... 88 7e-16
UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15; Mycobacterium|... 88 7e-16
UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 88 9e-16
UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, fami... 87 1e-15
UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalyt... 87 1e-15
UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep: CG3230... 87 2e-15
UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalyt... 87 2e-15
UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP045... 86 4e-15
UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theile... 85 5e-15
UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subuni... 83 2e-14
UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|R... 83 2e-14
UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2; Cul... 83 2e-14
UniRef50_A0MJN0 Cluster: Guanylate cyclase beta; n=11; Plasmodiu... 83 2e-14
UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl c... 83 3e-14
UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalyt... 83 3e-14
UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalyt... 83 3e-14
UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1; L... 83 3e-14
UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theile... 83 3e-14
UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep... 82 5e-14
UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-... 82 5e-14
UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC ... 82 6e-14
UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate ... 81 8e-14
UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulat... 81 8e-14
UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep: ... 81 8e-14
UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6; Mu... 81 8e-14
UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1; Ralst... 81 1e-13
UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gamb... 81 1e-13
UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A; ... 81 1e-13
UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 81 1e-13
UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to ENSANGP000... 80 2e-13
UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1; Chl... 80 2e-13
UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalyt... 80 2e-13
UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira inte... 80 2e-13
UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep: Gu... 80 2e-13
UniRef50_Q9GVB8 Cluster: Guanylyl cyclase enzyme; n=3; Plasmodiu... 80 2e-13
UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalyt... 80 2e-13
UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to ENSANGP000... 79 3e-13
UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalyt... 79 3e-13
UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1 p... 79 3e-13
UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whol... 79 6e-13
UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep: ... 79 6e-13
UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|R... 79 6e-13
UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1; M... 79 6e-13
UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalyt... 79 6e-13
UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12; Co... 79 6e-13
UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific... 79 6e-13
UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate ... 78 1e-12
UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1; Pseud... 77 1e-12
UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 77 1e-12
UniRef50_A2DBX9 Cluster: Adenylate and Guanylate cyclase catalyt... 77 2e-12
UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium falci... 77 2e-12
UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n... 77 2e-12
UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to ENSANGP000... 76 3e-12
UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to ENSANGP000... 76 3e-12
UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 76 4e-12
UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalyt... 76 4e-12
UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalyt... 76 4e-12
UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate ... 75 5e-12
UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA;... 75 5e-12
UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 75 5e-12
UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla mar... 75 5e-12
UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulat... 75 5e-12
UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera glyc... 75 5e-12
UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A p... 75 5e-12
UniRef50_A2FZG6 Cluster: Adenylate and Guanylate cyclase catalyt... 75 7e-12
UniRef50_A2DKP6 Cluster: Adenylate and Guanylate cyclase catalyt... 75 7e-12
UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6; Di... 75 7e-12
UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep: ... 75 9e-12
UniRef50_A2F3J3 Cluster: Adenylate and Guanylate cyclase catalyt... 75 9e-12
UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n... 74 1e-11
UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n... 74 2e-11
UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1; Al... 74 2e-11
UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 74 2e-11
UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalyt... 74 2e-11
UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriureti... 73 2e-11
UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific... 73 2e-11
UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to ENSANGP000... 73 3e-11
UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase ... 73 3e-11
UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalyt... 73 3e-11
UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalyt... 73 3e-11
UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 73 4e-11
UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 73 4e-11
UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalyt... 73 4e-11
UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3; D... 73 4e-11
UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2; ... 73 4e-11
UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=... 72 5e-11
UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla mar... 72 5e-11
UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1; ... 72 5e-11
UniRef50_A0LXB4 Cluster: Secreted protein containing adenylate/g... 72 5e-11
UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep: Gu... 72 5e-11
UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep: ... 72 5e-11
UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus japon... 72 5e-11
UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalyt... 72 5e-11
UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble gu... 72 6e-11
UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta proteobac... 72 6e-11
UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 72 6e-11
UniRef50_A2G2M4 Cluster: Adenylate and Guanylate cyclase catalyt... 72 6e-11
UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalyt... 72 6e-11
UniRef50_Q6E6T5 Cluster: L3i88 isoform b; n=5; Dictyocaulus vivi... 71 8e-11
UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 71 8e-11
UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 71 8e-11
UniRef50_A2DJR4 Cluster: Adenylate and Guanylate cyclase catalyt... 71 8e-11
UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor t... 71 1e-10
UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:... 71 1e-10
UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalyt... 71 1e-10
UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalyt... 71 1e-10
UniRef50_A2FB45 Cluster: Adenylate and Guanylate cyclase catalyt... 71 1e-10
UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalyt... 71 1e-10
UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 70 2e-10
UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla mar... 70 2e-10
UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|... 70 2e-10
UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=... 70 2e-10
UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep: ... 70 2e-10
UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriureti... 70 3e-10
UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira inte... 70 3e-10
UniRef50_Q9UDB0 Cluster: Type VI adenylyl cyclase; n=12; Euteleo... 70 3e-10
UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precur... 70 3e-10
UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7; Endopterygot... 69 3e-10
UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 69 5e-10
UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11... 69 5e-10
UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalyt... 69 5e-10
UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|R... 69 6e-10
UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25... 68 8e-10
UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalyt... 68 8e-10
UniRef50_A2F7J9 Cluster: Adenylate and Guanylate cyclase catalyt... 68 8e-10
UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla mar... 68 1e-09
UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalyt... 68 1e-09
UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalyt... 68 1e-09
UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella ve... 67 1e-09
UniRef50_A2DWV8 Cluster: Adenylate and Guanylate cyclase catalyt... 67 1e-09
UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 67 2e-09
UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 67 2e-09
UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, w... 67 2e-09
UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase ... 66 2e-09
UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2; Sinor... 66 2e-09
UniRef50_A7BYP5 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 66 2e-09
UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1; Pl... 66 2e-09
UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1; Mi... 66 2e-09
UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase ... 66 3e-09
UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 66 3e-09
UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalyt... 66 3e-09
UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, wh... 66 3e-09
UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to ENSANGP000... 66 4e-09
UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1; Janna... 66 4e-09
UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalyt... 66 4e-09
UniRef50_A2FPM7 Cluster: Adenylate and Guanylate cyclase catalyt... 66 4e-09
UniRef50_P16065 Cluster: Speract receptor precursor; n=7; Euechi... 66 4e-09
UniRef50_A2ES71 Cluster: Adenylate and Guanylate cyclase catalyt... 65 6e-09
UniRef50_UPI00006975C6 Cluster: Guanylyl CYclase family member (... 65 7e-09
UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 65 7e-09
UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalyt... 65 7e-09
UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7; ... 65 7e-09
UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1; Flavo... 64 1e-08
UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|R... 64 1e-08
UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella ve... 64 1e-08
UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2; ... 64 1e-08
UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena pyri... 64 2e-08
UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, wh... 64 2e-08
UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylat... 64 2e-08
UniRef50_Q5CUX5 Cluster: P-type ATpase fused to two adenyl cycla... 63 2e-08
UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 63 2e-08
UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, wh... 63 2e-08
UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular organis... 62 4e-08
UniRef50_A2DTD4 Cluster: Adenylate and Guanylate cyclase catalyt... 62 4e-08
UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 62 5e-08
UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 61 9e-08
UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA ... 61 9e-08
UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, wh... 61 9e-08
UniRef50_A2G2Z5 Cluster: Adenylate and Guanylate cyclase catalyt... 61 1e-07
UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 60 2e-07
UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2; Caeno... 60 2e-07
UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3; Caenor... 60 2e-07
UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1; Ca... 60 2e-07
UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalyt... 60 2e-07
UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalyt... 59 5e-07
UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|... 58 6e-07
UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n... 58 6e-07
UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 58 6e-07
UniRef50_A2D8T2 Cluster: Adenylate and Guanylate cyclase catalyt... 58 6e-07
UniRef50_A5NV94 Cluster: Response regulator receiver protein; n=... 58 1e-06
UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-... 58 1e-06
UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella ve... 57 1e-06
UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, w... 57 1e-06
UniRef50_A0BG69 Cluster: Chromosome undetermined scaffold_105, w... 57 1e-06
UniRef50_UPI00006CEB6E Cluster: Adenylate and Guanylate cyclase ... 57 2e-06
UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2; St... 56 3e-06
UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella ve... 56 3e-06
UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Parame... 56 4e-06
UniRef50_Q18628 Cluster: Putative uncharacterized protein acy-3;... 56 4e-06
UniRef50_Q17010 Cluster: Soluble guanylate cyclase; n=14; Cellia... 56 4e-06
UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n... 55 8e-06
UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, wh... 55 8e-06
UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, wh... 54 1e-05
UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella ve... 54 1e-05
UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane g... 54 2e-05
UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase ... 54 2e-05
UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep: C... 54 2e-05
UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, w... 54 2e-05
UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalyt... 53 3e-05
UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Parame... 53 3e-05
UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble gu... 52 4e-05
UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2; Xenopu... 52 6e-05
UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Parame... 52 6e-05
UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate ... 52 7e-05
UniRef50_Q3DXI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 52 7e-05
UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalyt... 52 7e-05
UniRef50_A2ECV6 Cluster: Adenylate and Guanylate cyclase catalyt... 52 7e-05
UniRef50_A6GG85 Cluster: Putative adenylate cyclase; n=1; Plesio... 51 1e-04
UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase ... 50 2e-04
UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic d... 50 2e-04
UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta proteobac... 50 2e-04
UniRef50_A0PW43 Cluster: Conserved hypothetical transmembrane pr... 50 2e-04
UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 50 2e-04
UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 50 3e-04
UniRef50_A2FB36 Cluster: Adenylate and Guanylate cyclase catalyt... 49 4e-04
UniRef50_UPI000065CD57 Cluster: Heat-stable enterotoxin receptor... 49 5e-04
UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1; Eryth... 49 5e-04
UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, wh... 49 5e-04
UniRef50_UPI0000DB7371 Cluster: PREDICTED: similar to Guanylyl c... 48 7e-04
UniRef50_A0Y7P2 Cluster: Adenylate/guanylate cyclase; n=1; marin... 48 7e-04
UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:... 48 9e-04
UniRef50_Q73L79 Cluster: Adenylate cyclase, putative; n=1; Trepo... 48 0.001
UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 48 0.001
UniRef50_UPI00006D0DB9 Cluster: Sodium/calcium exchanger protein... 47 0.002
UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor t... 47 0.002
UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha... 47 0.002
UniRef50_A7NLF3 Cluster: Adenylate/guanylate cyclase with GAF se... 46 0.003
UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalyt... 46 0.003
UniRef50_A2FVC2 Cluster: TB2/DP1, HVA22 family protein; n=3; Tri... 46 0.003
UniRef50_Q0EZJ3 Cluster: Adenylate cyclase; n=1; Mariprofundus f... 46 0.004
UniRef50_A0QDI3 Cluster: Adenylate and Guanylate cyclase catalyt... 46 0.004
UniRef50_Q4RZ92 Cluster: Chromosome 1 SCAF14944, whole genome sh... 46 0.005
UniRef50_Q8F375 Cluster: Adenylate cyclase; n=6; Leptospira|Rep:... 46 0.005
UniRef50_Q4BYX5 Cluster: Guanylate cyclase:Histidine kinase, HAM... 46 0.005
UniRef50_Q1MJZ0 Cluster: Putative adenylate/guanylate cyclase; n... 46 0.005
UniRef50_Q24GP9 Cluster: Adenylate and Guanylate cyclase catalyt... 46 0.005
UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella ve... 46 0.005
UniRef50_UPI00005A96A3 Cluster: PREDICTED: similar to adenylate ... 45 0.006
UniRef50_Q5N3R5 Cluster: Guanylyl cyclase; n=2; Synechococcus el... 45 0.006
UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit... 45 0.008
UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29... 45 0.008
UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4; ... 44 0.011
UniRef50_Q0EXI4 Cluster: Adenylate/guanylate cyclase catalytic d... 44 0.015
UniRef50_A3YYJ3 Cluster: Putative uncharacterized protein; n=1; ... 44 0.015
UniRef50_A0LFQ5 Cluster: Adenylate/guanylate cyclase precursor; ... 44 0.015
UniRef50_Q6DNF3 Cluster: Soluble guanylate cyclase gcy-37; n=2; ... 44 0.015
UniRef50_Q5BXY8 Cluster: SJCHGC07735 protein; n=1; Schistosoma j... 44 0.019
UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha... 44 0.019
UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha... 44 0.019
UniRef50_Q8DGN6 Cluster: Adenylate cyclase; n=1; Synechococcus e... 43 0.026
UniRef50_Q89II7 Cluster: Bll5647 protein; n=5; Bradyrhizobiaceae... 43 0.026
UniRef50_A2GB93 Cluster: Adenylate and Guanylate cyclase catalyt... 43 0.026
UniRef50_Q3DYQ5 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 43 0.034
UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome s... 42 0.045
UniRef50_Q7V427 Cluster: Putative adenylate cyclase precursor; n... 42 0.045
UniRef50_A3WDP1 Cluster: Adenylate/Guanylate Cyclase; n=1; Eryth... 42 0.045
UniRef50_A0NC46 Cluster: ENSANGP00000018386; n=1; Anopheles gamb... 42 0.045
UniRef50_Q4AKB7 Cluster: Similar to Adenylate cyclase family 3; ... 42 0.059
UniRef50_A5NV55 Cluster: Putative adenylate/guanylate cyclase; n... 42 0.078
UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, w... 42 0.078
UniRef50_Q6KZD1 Cluster: Histidinol dehydrogenase; n=5; cellular... 42 0.078
UniRef50_Q1IJR6 Cluster: Adenylate/guanylate cyclase; n=1; Acido... 41 0.10
UniRef50_A5UWN3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 41 0.10
UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble gu... 41 0.14
UniRef50_Q61150 Cluster: Guanylyl cyclase C; n=6; Euteleostomi|R... 41 0.14
UniRef50_Q2W153 Cluster: Adenylate cyclase 1; n=3; Magnetospiril... 41 0.14
UniRef50_Q0LCB6 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 41 0.14
UniRef50_Q20XY3 Cluster: Adenylate/guanylate cyclase; n=1; Rhodo... 40 0.18
UniRef50_Q1M6K1 Cluster: Putative transmembrane adenylate cyclas... 40 0.18
UniRef50_A0YWU6 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 40 0.18
UniRef50_A0LB38 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 40 0.18
UniRef50_Q7R2Z8 Cluster: GLP_385_25897_32469; n=1; Giardia lambl... 40 0.18
UniRef50_Q7A2G7 Cluster: Adenylate cyclase; n=4; Nostocaceae|Rep... 40 0.24
UniRef50_Q0LGQ8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 40 0.24
UniRef50_A4BGN9 Cluster: Adenylate cyclase, family 3; n=1; Reine... 40 0.24
UniRef50_A0Y8Z4 Cluster: Adenylate cyclase; n=1; marine gamma pr... 40 0.24
UniRef50_A0P2D1 Cluster: Adenylate cyclase 1 protein; n=2; Stapp... 40 0.24
UniRef50_A0P034 Cluster: Adenylate cyclase; n=1; Stappia aggrega... 40 0.24
UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;... 40 0.24
UniRef50_Q7UN49 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 40 0.32
UniRef50_Q5N0S8 Cluster: Guanylyl cyclase; n=2; Synechococcus el... 40 0.32
UniRef50_Q1VN94 Cluster: Two-component hybrid sensor and regulat... 40 0.32
UniRef50_Q04UM6 Cluster: Adenylate cyclase related protein; n=4;... 40 0.32
UniRef50_Q7UPH0 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 39 0.42
UniRef50_A6PCE2 Cluster: Putative adenylate/guanylate cyclase pr... 39 0.42
UniRef50_A0NUX8 Cluster: Adenylate cyclase 1 protein; n=1; Stapp... 39 0.42
UniRef50_Q5ZVF0 Cluster: Adenylate cyclase PLUS two component hy... 39 0.55
UniRef50_Q2LSB8 Cluster: Adenylate and guanylate cyclase catalyt... 39 0.55
UniRef50_Q0BS82 Cluster: Two-component sensor and regulator; n=1... 39 0.55
UniRef50_Q2GNE8 Cluster: Putative uncharacterized protein; n=1; ... 39 0.55
UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8; E... 39 0.55
UniRef50_UPI0000E490E0 Cluster: PREDICTED: similar to guanylate ... 38 0.73
UniRef50_Q9HZ23 Cluster: CyaB; n=13; Gammaproteobacteria|Rep: Cy... 38 0.73
UniRef50_Q1N6Q8 Cluster: Probable adenylate cyclase; n=1; Oceano... 38 0.73
UniRef50_Q73QP2 Cluster: Adenylate/guanylate cyclase catalytic d... 38 0.96
UniRef50_Q3E0R2 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 38 0.96
UniRef50_Q113T7 Cluster: Adenylate/guanylate cyclase; n=1; Trich... 38 0.96
UniRef50_Q0B020 Cluster: Transmembrane sensor domain-like protei... 38 0.96
UniRef50_A6M2S6 Cluster: Sugar isomerase; n=2; Firmicutes|Rep: S... 38 0.96
UniRef50_A4MIN5 Cluster: Adenylate/guanylate cyclase precursor; ... 38 0.96
UniRef50_UPI000038C573 Cluster: COG2114: Adenylate cyclase, fami... 38 1.3
UniRef50_Q98GL0 Cluster: Mlr3277 protein; n=5; Rhizobiales|Rep: ... 38 1.3
UniRef50_Q2SJM3 Cluster: Adenylate cyclase, family 3; n=1; Hahel... 38 1.3
UniRef50_Q10Z12 Cluster: Adenylate/guanylate cyclase; n=1; Trich... 38 1.3
UniRef50_Q0VSG5 Cluster: Adenylate cyclase family proteine ident... 38 1.3
UniRef50_A7BXW8 Cluster: Adenylate cyclase; n=3; Beggiatoa|Rep: ... 38 1.3
UniRef50_A0LDY9 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 38 1.3
UniRef50_A0LAQ0 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 38 1.3
UniRef50_Q176P1 Cluster: Putative uncharacterized protein; n=1; ... 38 1.3
UniRef50_A2G3F5 Cluster: Adenylate and Guanylate cyclase catalyt... 38 1.3
UniRef50_Q64EP7 Cluster: Histidinol dehydrogenase; n=2; environm... 38 1.3
UniRef50_Q9A4X2 Cluster: Putative uncharacterized protein; n=2; ... 37 1.7
UniRef50_Q8F7F2 Cluster: Adenylate cyclase; n=2; Leptospira inte... 37 1.7
UniRef50_Q8F2W9 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 37 1.7
UniRef50_Q2W7Z5 Cluster: Adenylate cyclase 1; n=2; Magnetospiril... 37 1.7
UniRef50_Q1PXG2 Cluster: Putative uncharacterized protein; n=1; ... 37 1.7
UniRef50_Q1GD86 Cluster: Adenylate/guanylate cyclase; n=4; Rhodo... 37 1.7
UniRef50_Q15YL4 Cluster: Adenylate/guanylate cyclase precursor; ... 37 1.7
UniRef50_Q10W13 Cluster: Adenylate/guanylate cyclase; n=2; Oscil... 37 1.7
UniRef50_A6LJV0 Cluster: Putative adenylate/guanylate cyclase; n... 37 1.7
UniRef50_A5Z902 Cluster: Putative uncharacterized protein; n=1; ... 37 1.7
UniRef50_A0L8N6 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 37 1.7
UniRef50_Q9P5M4 Cluster: Related to SCP160 protein; n=3; Sordari... 37 1.7
UniRef50_P40138 Cluster: Adenylate cyclase 2; n=3; Cystobacterin... 37 1.7
UniRef50_Q92SD3 Cluster: PUTATIVE ADENYLATE CYCLASE TRANSMEMBRAN... 37 2.2
UniRef50_Q7A2H3 Cluster: Adenylate cyclase; n=5; Nostocaceae|Rep... 37 2.2
UniRef50_Q44R57 Cluster: Similar to Adenylate cyclase family 3; ... 37 2.2
UniRef50_A3HTY4 Cluster: Putative uncharacterized protein; n=1; ... 37 2.2
UniRef50_A2C6I2 Cluster: Putative uncharacterized protein; n=1; ... 37 2.2
UniRef50_Q23GD8 Cluster: Putative uncharacterized protein; n=1; ... 37 2.2
UniRef50_Q22A82 Cluster: Protein kinase domain containing protei... 37 2.2
UniRef50_Q5DTS7 Cluster: MKIAA4004 protein; n=2; Murinae|Rep: MK... 36 2.9
UniRef50_Q6MNW4 Cluster: Adenylate cyclase precursor; n=1; Bdell... 36 2.9
UniRef50_Q5FPD7 Cluster: Adenylate cyclase; n=1; Gluconobacter o... 36 2.9
UniRef50_P72951 Cluster: Adenylate cyclase; n=2; Chroococcales|R... 36 2.9
UniRef50_Q1DD79 Cluster: Adenylate/guanylate cyclase domain prot... 36 2.9
UniRef50_A4AWH4 Cluster: Adenylate cyclase-related protein; n=2;... 36 2.9
UniRef50_A1WY91 Cluster: Putative adenylate/guanylate cyclase pr... 36 2.9
UniRef50_A0WBT7 Cluster: Adenylate/guanylate cyclase precursor; ... 36 2.9
UniRef50_Q9JK77 Cluster: Adenylyl cyclase 3; n=7; Euteleostomi|R... 36 3.9
UniRef50_Q5ZVW6 Cluster: Adenylate cyclase 1 protein; n=4; Legio... 36 3.9
UniRef50_O83498 Cluster: Adenylate cyclase; n=1; Treponema palli... 36 3.9
UniRef50_Q2YZX8 Cluster: Adenylate/guanylate cyclase; n=1; uncul... 36 3.9
UniRef50_A3HV31 Cluster: Two-component response regulator; n=1; ... 36 3.9
UniRef50_A1I794 Cluster: Putative adenylate/guanylate cyclase; n... 36 3.9
UniRef50_A0YII8 Cluster: Adenylate cyclase; n=2; Bacteria|Rep: A... 36 3.9
UniRef50_Q4PFK7 Cluster: Putative uncharacterized protein; n=1; ... 36 3.9
UniRef50_UPI0000E49F77 Cluster: PREDICTED: similar to Guanylate ... 36 5.1
UniRef50_Q97M75 Cluster: Sensor protein; n=1; Clostridium acetob... 36 5.1
UniRef50_Q1YP13 Cluster: Probable adenylate cyclase; n=1; gamma ... 36 5.1
UniRef50_Q1FIA2 Cluster: Putative uncharacterized protein; n=1; ... 36 5.1
UniRef50_Q111B1 Cluster: Adenylate/guanylate cyclase; n=2; Bacte... 36 5.1
UniRef50_Q0VR65 Cluster: Adenylate cyclase; n=1; Alcanivorax bor... 36 5.1
UniRef50_A4CY85 Cluster: Serine/threonine kinase; n=2; Synechoco... 36 5.1
UniRef50_Q6LFB4 Cluster: Putative uncharacterized protein; n=2; ... 36 5.1
UniRef50_Q24E28 Cluster: Putative uncharacterized protein; n=1; ... 36 5.1
UniRef50_P40137 Cluster: Adenylate cyclase 1; n=2; Stigmatella a... 36 5.1
UniRef50_Q2BGD8 Cluster: Adenylate cyclase; n=1; Neptuniibacter ... 35 6.8
UniRef50_Q1GZE1 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 35 6.8
UniRef50_Q0STI2 Cluster: Drug resistance transporter, EmrB/QacA ... 35 6.8
UniRef50_A4BFI0 Cluster: Adenylate cyclase, family 3; n=1; Reine... 35 6.8
UniRef50_A1T6C4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 35 6.8
UniRef50_A0LKW1 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 35 6.8
UniRef50_Q0U858 Cluster: Putative uncharacterized protein; n=1; ... 35 6.8
UniRef50_Q9K6Z2 Cluster: Histidinol dehydrogenase; n=10; Firmicu... 35 6.8
UniRef50_UPI0000E4A5D0 Cluster: PREDICTED: similar to adenylyl c... 35 9.0
UniRef50_Q8F210 Cluster: Adenylate cyclase; n=2; Leptospira inte... 35 9.0
UniRef50_Q8EXU0 Cluster: Adenylate cyclase; n=2; Leptospira inte... 35 9.0
UniRef50_Q89BY7 Cluster: Bll8011 protein; n=1; Bradyrhizobium ja... 35 9.0
UniRef50_Q0LGT9 Cluster: Response regulator receiver; n=1; Herpe... 35 9.0
UniRef50_A7CWV1 Cluster: Putative adenylate/guanylate cyclase; n... 35 9.0
UniRef50_A6TLP3 Cluster: Putative uncharacterized protein precur... 35 9.0
UniRef50_A4M524 Cluster: Putative uncharacterized protein; n=2; ... 35 9.0
UniRef50_A0P1E4 Cluster: Putative Adenylate/Guanylate cyclase; n... 35 9.0
UniRef50_A0LFQ6 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 35 9.0
UniRef50_Q18ED9 Cluster: Cell surface calcium-binding acidic-rep... 35 9.0
UniRef50_P19485 Cluster: Adenylate cyclase 1; n=2; Sinorhizobium... 35 9.0
>UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG32158-PB, isoform B - Tribolium castaneum
Length = 1333
Score = 376 bits (924), Expect = e-102
Identities = 211/428 (49%), Positives = 267/428 (62%), Gaps = 38/428 (8%)
Query: 9 DRVCAVQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIAT----------MIL 58
D V +Y E+DRML +YF CS +TA+ +VQ++ N + +
Sbjct: 801 DPVKEAKYILEKDRMLTLYFFCSTFCFTAIFLVQIVLINSKILRLNLNNFKKFLTNYRYF 860
Query: 59 CGIIVVSVTYLIFAIDLKFAGGKLKRISKRVHNNRTLAQLMSFI----VVGAVILQI--- 111
C + S+ L + + K+ +SK +H NR +AQ+ SFI + G V+L
Sbjct: 861 CIVCHKSIFNLNKNVWFQNVHLKIFAVSKYIHKNRNIAQIFSFIMAVCIYGLVMLHTVSF 920
Query: 112 -------QVVMVQEVLGVTNNTN--VPSYENSGGNC-PYDMNEHYLQVTLMAMFLCAVHQ 161
++ + + +N TN V S N +C PY + ++ L + ++M CAV+Q
Sbjct: 921 PALSLPEEIQCLNSTIVDSNCTNFTVYSLNNDNKDCKPYFLIDYLLLLVFISMIACAVYQ 980
Query: 162 IXXXXXXXXXXXXXXXXXXXXXXQEHLYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVA 221
+ ++ Y + + L QQ+ NI I +G +A
Sbjct: 981 VLISLFKTIILLGGMAGFIAA----YITYTKEVHAMHNETTL--TQQYVNIVILVGFVIA 1034
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
L+LH QQTE+TYRLDF+WKLQA EEKEDMEHL+AYNRKLLANILP HVA+HFL SDKN D
Sbjct: 1035 LILHGQQTEATYRLDFVWKLQATEEKEDMEHLEAYNRKLLANILPVHVAEHFLNSDKNND 1094
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
ELYHEQCD VC+MFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDE+L+E+
Sbjct: 1095 -----ELYHEQCDFVCIMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEDQ 1149
Query: 342 FKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRI 401
FKYIEKIKSTGATYMAASGLT +T D+ GYRHVTAMADYALR++EQL VNEHSFN FRI
Sbjct: 1150 FKYIEKIKSTGATYMAASGLTQNTCDMQGYRHVTAMADYALRIQEQLAEVNEHSFNHFRI 1209
Query: 402 RIGKSCSP 409
RIG + P
Sbjct: 1210 RIGINVGP 1217
Score = 151 bits (366), Expect = 7e-35
Identities = 78/124 (62%), Positives = 91/124 (73%), Gaps = 4/124 (3%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GIN+GPVVAGVIGARKPQYDIWGNAVNVASRMDSTG+LD IQVT+EVY ILS+RGY
Sbjct: 1208 RIRIGINVGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGVLDKIQVTKEVYQILSSRGY 1267
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG---VGDSIPDDIYNNPIPSTSSEGAVPPRPEHRP-LD 550
L CRGT+ VKGKG M TYFLEG +I NP+ + +S+ + P LD
Sbjct: 1268 PLTCRGTIQVKGKGTMETYFLEGRCKKPTQSETNITVNPLANINSDCSKTFLPHQTTVLD 1327
Query: 551 TLSE 554
T+SE
Sbjct: 1328 TISE 1331
Score = 62.1 bits (144), Expect = 5e-08
Identities = 72/278 (25%), Positives = 115/278 (41%), Gaps = 50/278 (17%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHF 273
I L VA + E R F+ Q E + ++ +LL ++LP HVA
Sbjct: 457 ILLCGNVAGVCTHYPREVAQRKAFLETRQCIEARLKIQRENQQQERLLLSVLPRHVAME- 515
Query: 274 LCSDKNIDQFDAQ--ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 331
+ +D +AQ ++Y ++ ++V ++FA I F+ L E +R+LNE+ A
Sbjct: 516 MKADIAGQPKEAQFHKIYIQRHENVSILFADICGFTT----LSDQCTAEELVRILNELFA 571
Query: 332 DFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYV 391
FD + AE + +IK G Y SGL + D H + L + + + V
Sbjct: 572 RFDRLAAEH---HCLRIKLLGDCYYCVSGLPEARPD-----HAHCTVEMGLDMIDAIALV 623
Query: 392 NEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIG 451
E S N +RV + G RV G V+G
Sbjct: 624 RE--------------------VMSVNVNMRVGIHTG------RVHCG---------VLG 648
Query: 452 ARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
RK Q+D+W N V +A+ M+S G+ + +T+E L
Sbjct: 649 LRKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCL 686
>UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|Rep:
CG32158-PB, isoform B - Drosophila melanogaster (Fruit
fly)
Length = 1662
Score = 341 bits (838), Expect = 4e-92
Identities = 198/422 (46%), Positives = 266/422 (63%), Gaps = 29/422 (6%)
Query: 9 DRVCAVQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTY 68
D V +Y +E DRML VYF CSL+V I++L+ F + + +A +++ + +
Sbjct: 801 DNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVF 860
Query: 69 LIFAIDLKFA-GGKLKRISKRVHNNRTLAQLMSFIVVGAVILQI--------QVVMVQ-- 117
L+ + F +KR S R+H+NR ++QL +F V ++L Q+ ++Q
Sbjct: 861 LVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMESGRQMELLQRR 920
Query: 118 ----EVLGVT--NNT--NVPSYENSGGNCPYDMNEH-YLQVTLMAMFLCAVHQIXXXXXX 168
+V G N+T N Y+ +C + + + +L +TL++M CA +Q+
Sbjct: 921 RFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLK 980
Query: 169 XXXXXXXXXXXXXXXXQEHLYYRNHFYDYQHRCGLDWNQQWTNIAIALGA-TVALLLHSQ 227
+LY R+ Q + ++ +I L A +AL+ HS
Sbjct: 981 LLLLLLASGSYMACSS--NLYSRSREMS-QELANEEALLRYIIDSIFLFAFMLALIFHSH 1037
Query: 228 QTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQE 287
QTE+TYRLDFIWKLQA EEKEDMEHLQAYNRKLL NILP HVA+HFL +K++D +
Sbjct: 1038 QTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLD-----D 1092
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LYHEQCDSVC++FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDE+L+EE F+ IEK
Sbjct: 1093 LYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEK 1152
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
IKSTGATYMAASGLT +T D V + HVTAMADYAL+L ++++ VN HSFN FR+RIG +
Sbjct: 1153 IKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINI 1212
Query: 408 SP 409
P
Sbjct: 1213 GP 1214
Score = 145 bits (351), Expect = 4e-33
Identities = 66/83 (79%), Positives = 75/83 (90%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GINIGPVVAGVIGA KPQYDIWGNAVNVASRMDSTGL+DHIQVTQE+ IL RG+
Sbjct: 1205 RMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGF 1264
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
+L CRG+VDVKGKG+M+TYFL+G
Sbjct: 1265 ELTCRGSVDVKGKGSMITYFLKG 1287
Score = 58.8 bits (136), Expect = 5e-07
Identities = 70/283 (24%), Positives = 112/283 (39%), Gaps = 53/283 (18%)
Query: 210 TNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHV 269
T +A+ L + H + E R FI Q E + + +LL ++LP HV
Sbjct: 454 TLVALLLANLTGVYTHWPK-EKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHV 512
Query: 270 AQHF---LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
A + QF ++Y ++ ++V ++FA I F+ L E +RLL
Sbjct: 513 AMEMKDDIAGQPRDTQF--HKIYIQRHENVSILFADICGFTS----LSDQCTAEELVRLL 566
Query: 327 NEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLRE 386
NE+ A FD + AE + +IK G Y SGL D H + L + +
Sbjct: 567 NELFARFDRLAAEH---HCLRIKLLGDCYYCVSGLPEPRPD-----HAHCAVEMGLDMID 618
Query: 387 QLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVV 446
+ V E + N +RV + G RV G+
Sbjct: 619 AIALVRE--------------------VMAVNVNMRVGIHTG------RVHCGV------ 646
Query: 447 AGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
+G K Q+D+W N V +A+ M+S G+ + +T+E L
Sbjct: 647 ---LGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCL 686
>UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila
melanogaster|Rep: AT09365p - Drosophila melanogaster
(Fruit fly)
Length = 532
Score = 299 bits (733), Expect = 2e-79
Identities = 142/190 (74%), Positives = 164/190 (86%), Gaps = 5/190 (2%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL+ HS QTE+TYRLDFIWKLQA EEKEDMEHLQAYNRKLL NILP HVA+HFL +K+
Sbjct: 49 LALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKH 108
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+D +LYHEQCDSVC++FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDE+L+E
Sbjct: 109 LD-----DLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSE 163
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
E F+ IEKIKSTGATYMAASGLT +T D V + HVTAMADYAL+L ++++ VN HSFN F
Sbjct: 164 ERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNF 223
Query: 400 RIRIGKSCSP 409
R+RIG + P
Sbjct: 224 RMRIGINIGP 233
Score = 89.0 bits (211), Expect = 4e-16
Identities = 41/46 (89%), Positives = 43/46 (93%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQ 480
R+ GINIGPVVAGVIGA KPQYDIWGNAVNVASRMDSTGL+DHIQ
Sbjct: 224 RMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQ 269
>UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome shotgun
sequence; n=3; Euteleostomi|Rep: Chromosome 9 SCAF14991,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1208
Score = 265 bits (650), Expect = 3e-69
Identities = 126/190 (66%), Positives = 153/190 (80%), Gaps = 5/190 (2%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL LH QQ EST RLDF+WKLQA EEKE+ME LQAYNR+LL NILP+ VA HFL ++
Sbjct: 947 LALYLHGQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 1006
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADFDEI++E
Sbjct: 1007 ND-----ELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1061
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
E F+ +EKIK+ G+TYMAASGL +ST D G H+ A+ADYA+RLREQ++Y+NEHSFN F
Sbjct: 1062 ERFRQLEKIKTIGSTYMAASGLNDSTYDREGRSHILALADYAMRLREQMKYINEHSFNNF 1121
Query: 400 RIRIGKSCSP 409
+++IG + P
Sbjct: 1122 QMKIGLNMGP 1131
Score = 130 bits (314), Expect = 1e-28
Identities = 58/77 (75%), Positives = 66/77 (85%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N+GPVVAGVIGARKPQYDIWGN VNVASRMDSTG+ D+IQVT ++Y +L + GYKL C
Sbjct: 1126 GLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDYIQVTTDLYHVLDSNGYKLDC 1185
Query: 499 RGTVDVKGKGNMVTYFL 515
RG V VKGKG M TYFL
Sbjct: 1186 RGLVKVKGKGEMTTYFL 1202
Score = 48.0 bits (109), Expect = 9e-04
Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 13/107 (12%)
Query: 397 NCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGALIVRRVPAGINI--------G 443
+C RI+I C + A A+C + + V+ A+ + R G+N+ G
Sbjct: 425 HCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSG 484
Query: 444 PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
V GV+G RK Q+D+W N V +A++M++ G I +T+ L+
Sbjct: 485 RVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLN 531
Score = 36.7 bits (81), Expect = 2.2
Identities = 20/93 (21%), Positives = 49/93 (52%), Gaps = 3/93 (3%)
Query: 14 VQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL--IF 71
+QY+ + D + Y +C L V+ + +Q++ F T + + I II+ ++ ++ I+
Sbjct: 692 LQYSRKIDDRIGGYVACILFVFFCICFIQIIIFPKTALMLGLYISIFIILTNILFVCAIY 751
Query: 72 AIDLKFAGGKLKRISKRVHNNRTLAQLMSFIVV 104
+ +F L+ ++K++ +RT + L+ +
Sbjct: 752 SCIKRFPAA-LQSVTKKIVQSRTNSTLVGVFTI 783
>UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC
4.6.1.1) (Adenylate cyclase type VI) (ATP
pyrophosphate-lyase 6) (Adenylyl cyclase 6)
(Ca(2+)-inhibitable adenylyl cyclase).; n=2;
Coelomata|Rep: Adenylate cyclase type 6 (EC 4.6.1.1)
(Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6)
(Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl
cyclase). - Xenopus tropicalis
Length = 355
Score = 262 bits (643), Expect = 2e-68
Identities = 125/190 (65%), Positives = 153/190 (80%), Gaps = 5/190 (2%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL LH+QQ EST RLDF+WKLQA EKE+ME LQAYNR+LL NILP+ VA HFL +
Sbjct: 94 LALYLHAQQVESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAAHFLAREHR 153
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADFDEI++E
Sbjct: 154 ND-----ELYYQSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 208
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
E FK +EKIK+ G+TYMAASGL ++T D G H+TA+ADYA++LREQ++Y+NEHSFN F
Sbjct: 209 EKFKQLEKIKTIGSTYMAASGLNDTTYDKEGKTHITALADYAMKLREQMKYINEHSFNNF 268
Query: 400 RIRIGKSCSP 409
+++IG + P
Sbjct: 269 QMKIGLNIGP 278
Score = 132 bits (318), Expect = 4e-29
Identities = 58/77 (75%), Positives = 67/77 (87%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIGPVVAGVIGARKPQYDIWGN VNVASRMDSTGL D IQVT ++Y +L+A+GY++ C
Sbjct: 273 GLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMEC 332
Query: 499 RGTVDVKGKGNMVTYFL 515
RG + VKGKG M TYFL
Sbjct: 333 RGVIKVKGKGEMTTYFL 349
>UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41;
Deuterostomia|Rep: Adenylate cyclase type 5 - Homo
sapiens (Human)
Length = 1261
Score = 260 bits (638), Expect = 7e-68
Identities = 122/190 (64%), Positives = 154/190 (81%), Gaps = 5/190 (2%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL LH+QQ EST RLDF+WKLQA EEKE+ME LQAYNR+LL NILP+ VA HFL ++
Sbjct: 999 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 1058
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADFDEI++E
Sbjct: 1059 ND-----ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1113
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
+ F+ +EKIK+ G+TYMAASGL +ST D VG H+ A+AD+A++L +Q++Y+NEHSFN F
Sbjct: 1114 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 1173
Query: 400 RIRIGKSCSP 409
+++IG + P
Sbjct: 1174 QMKIGLNIGP 1183
Score = 132 bits (318), Expect = 4e-29
Identities = 59/79 (74%), Positives = 67/79 (84%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIGPVVAGVIGARKPQYDIWGN VNVASRMDSTG+ D IQVT ++Y +L+A Y+L C
Sbjct: 1178 GLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC 1237
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M+TYFL G
Sbjct: 1238 RGVVKVKGKGEMMTYFLNG 1256
Score = 59.3 bits (137), Expect = 4e-07
Identities = 67/261 (25%), Positives = 111/261 (42%), Gaps = 53/261 (20%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQ--ELYHEQCDSVCVMFASIPNFSEFYVELEGN 316
+LL ++LP HVA + +D N Q D ++Y ++ D+V ++FA I F+ L
Sbjct: 430 RLLLSVLPRHVAME-MKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS----LASQ 484
Query: 317 NEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTA 376
E + LNE+ A FD++ AE + +IK G Y SGL + D H
Sbjct: 485 CTAQELVMTLNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARAD-----HAHC 536
Query: 377 MADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRV 436
+ + + E + V E + N +RV + G RV
Sbjct: 537 CVEMGMDMIEAISLVRE--------------------VTGVNVNMRVGIHSG------RV 570
Query: 437 PAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKL 496
G+ +G RK Q+D+W N V +A+ M++ G I +T+ + L+ Y++
Sbjct: 571 HCGV---------LGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEV 620
Query: 497 R--CRGTVDVKGKGNMVTYFL 515
C G + K + + FL
Sbjct: 621 EPGCGGERNAYLKEHSIETFL 641
>UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 15
SCAF14542, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 971
Score = 254 bits (621), Expect = 8e-66
Identities = 151/339 (44%), Positives = 201/339 (59%), Gaps = 39/339 (11%)
Query: 210 TNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHV 269
T++ + +A+ H QQ E T RLDF+W++QA EE +M+ L+ +N +L NILP HV
Sbjct: 560 TSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV 619
Query: 270 AQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEI 329
A+HFL D+ D +ELY + D+V VMFASIP F++FY + E NN+GVECLRLLNEI
Sbjct: 620 ARHFLEKDR-----DNEELYSQSYDAVGVMFASIPAFADFYSQTEMNNQGVECLRLLNEI 674
Query: 330 IADFDEI-----------------------LAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
IADFDE+ L E+ F+ IEKIK+ G+TYMA SGL+ Q
Sbjct: 675 IADFDEVRSKACRGGGTKSFNLSLLSWSQLLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQ 734
Query: 367 DLVG-YRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRV 425
+ H+ A+AD+A+ L E +Q +N+HSFN F +RIG+
Sbjct: 735 QCEDKWGHLCALADFAIALNESIQEINKHSFNNFELRIGEG---RGRRPRRWRRRWPAGA 791
Query: 426 EPGGALIVRR---VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
GGA + AG+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQV
Sbjct: 792 GEGGAALTATDGLSLAGMAQGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQVP 851
Query: 483 QEVYDILSARGYKLRCRGTVDVKG----KGNMVTYFLEG 517
+E + IL RG+ RG + VKG +G + T+FL G
Sbjct: 852 EETFLILKERGFAFEYRGEIYVKGISEQEGKIRTHFLLG 890
Score = 50.4 bits (115), Expect = 2e-04
Identities = 37/150 (24%), Positives = 66/150 (44%), Gaps = 16/150 (10%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHE----QCDSVCVMFASIPNFSEFYVELE 314
+L+ ++LP V + N++ Q +H + ++V ++FA + F+ L
Sbjct: 85 RLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLP 144
Query: 315 GNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHV 374
E +R+LNE+ A FD + E + +IK G Y SGL QD H
Sbjct: 145 AQ----ELVRMLNELFARFDRLAHEH---HCLRIKILGDCYYCVSGLPEPRQD-----HA 192
Query: 375 TAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+ L + + ++YV + + +RIG
Sbjct: 193 HCCVEMGLSMLKTIRYVRSRTKHDIDMRIG 222
Score = 48.8 bits (111), Expect = 5e-04
Identities = 51/224 (22%), Positives = 100/224 (44%), Gaps = 26/224 (11%)
Query: 323 LRLLNEIIADFDEILAEEPFK-YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
L ++N++ DE L + + YI + ++ + G TN + L V + +
Sbjct: 97 LEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLPAQELVRMLNELF 156
Query: 382 LRLREQLQYVNEHSFNCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGALIVRR- 435
R ++L H +C RI+I C + A+C + + + + R
Sbjct: 157 ARF-DRLA----HEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMLKTIRYVRS 211
Query: 436 -------VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
+ GI+ G V+ GV+G RK Q+D+W V++A++++S G+ I +++ D
Sbjct: 212 RTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDC 271
Query: 489 LSARGYKL---RCRGTVDVKGKGNMVTYFLEGVGD---SIPDDI 526
L+ Y++ + D + N+ T+ + D S+P+DI
Sbjct: 272 LNG-DYEVEEGHGKDRNDFLRRHNIETFLIRQPEDALLSLPEDI 314
>UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1052
Score = 242 bits (592), Expect = 3e-62
Identities = 152/418 (36%), Positives = 226/418 (54%), Gaps = 33/418 (7%)
Query: 16 YTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYLIFAID- 74
Y+ ERDRM K Y SC +VY +L QLL + +A + L ++V++TYL+ +
Sbjct: 561 YSQERDRMFKSYTSCVFLVYLFILGTQLLVLPRNYVTLA-VFLSIFLIVAITYLLVVSEK 619
Query: 75 LKFAGGKLKRISKRVHNNRTLAQLM-SFIVVGAVILQI---------------QVVMVQE 118
F L +S + +R + +++ S +++G + + ++ + E
Sbjct: 620 FSFLPESLTNLSSTICQSRVICRIIASILIIGLYVAAVGNLFGCDEPPTPEFTKIFLNNE 679
Query: 119 VLGVTNNTNVPSYEN-SGGNCPYDMNEHYLQVTLMAMFLCAVH-QIXXXXXXXXXXXXXX 176
V N + P +C Y + VTL+ M CAV Q+
Sbjct: 680 TKLVCNASRYPPQLGVENQSCDYPQYVTFC-VTLV-MIGCAVFLQLSTVLKFSLLTVMAI 737
Query: 177 XXXXXXXXQEHLYYRNHFYDYQHRCGLDWNQ--QWTNIAIALGAT--VALLLHSQQTEST 232
+ H D+ CGL +W++++I + +AL H E
Sbjct: 738 VYILLVQYVAKNSFLRH--DFLQFCGLGSGHFIEWSDLSILIVVIFILALTAHGYLHEQI 795
Query: 233 YRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQ 292
RLDF+WKLQA EEK++ME L+ YN+KLL NILP HVAQHFL N ++ +LY++
Sbjct: 796 SRLDFLWKLQATEEKKEMEQLREYNKKLLYNILPVHVAQHFLGHKANKNE----DLYYQS 851
Query: 293 CDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTG 352
CD V VMF++I NFS+FY EL+ N EGVECLRLLNEI+ADFDE+L+E F+ IEKIK+ G
Sbjct: 852 CDKVAVMFSNICNFSDFYTELDANGEGVECLRLLNEILADFDELLSEPQFQCIEKIKTIG 911
Query: 353 ATYMAASGLTNSTQD-LVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
TYMAASG+ +Q+ L H+ MAD+A+ ++ +L+ +N HSFN F ++IG + P
Sbjct: 912 ETYMAASGIKPESQEKLATLNHICTMADFAMAMKRKLEDINLHSFNNFAMKIGLNFGP 969
Score = 122 bits (293), Expect = 5e-26
Identities = 57/79 (72%), Positives = 64/79 (81%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N GPVVAGVIGA KPQYDIWG+ VNVASRM STG +HIQVT+ +Y+ILS RGY C
Sbjct: 964 GLNFGPVVAGVIGAHKPQYDIWGDTVNVASRMYSTGKDNHIQVTKAMYEILSTRGYTFDC 1023
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG MVTY+L G
Sbjct: 1024 RGLVAVKGKGKMVTYWLLG 1042
Score = 59.7 bits (138), Expect = 3e-07
Identities = 65/282 (23%), Positives = 120/282 (42%), Gaps = 49/282 (17%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + + A + + TE + R F+ + E + ++ +LL ++LP +VA
Sbjct: 257 NLLLFICANITGVFTHYPTEISQRQAFLETRRCIEARLTIQKENQNQERLLLSVLPRYVA 316
Query: 271 QHFLCS-DKNIDQFDA-QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNE 328
+ I Q ++Y ++ ++V ++FA I F+ L ++ LNE
Sbjct: 317 MEMKDDIESGISQNSQFHKIYIQRHENVSILFADIEGFTV----LSSQCTAQSLIKTLNE 372
Query: 329 IIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQL 388
+ A FD++ E + +IK G Y SGL + D H + + L + + +
Sbjct: 373 LYARFDQLAVE---NHCLRIKILGDCYYCVSGLPDPRPD-----HAHSCIEMGLAMIDAI 424
Query: 389 QYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAG 448
+V + A+ N +RV V G +V +G+
Sbjct: 425 SFVRD--------------------ATQVNLNMRVGVHMG------KVHSGV-------- 450
Query: 449 VIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
+G K QYD+W + V +A+ M+S GL + +T+EV D L+
Sbjct: 451 -LGLVKWQYDVWSDDVTIANHMESGGLPGRVHITKEVLDCLN 491
>UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebrate
adenylate cyclase 2 (Brain) (ADCY2); n=2; Danio
rerio|Rep: Novel protein similar to vertebrate adenylate
cyclase 2 (Brain) (ADCY2) - Danio rerio
Length = 793
Score = 237 bits (581), Expect = 6e-61
Identities = 135/282 (47%), Positives = 180/282 (63%), Gaps = 34/282 (12%)
Query: 234 RLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQC 293
RLDF+W+ + +E E++E ++ NR LL N+LP HVA+HFL +N + ++LYH+
Sbjct: 546 RLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFL--GRN---WKNEDLYHQSY 600
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
D+VCVMFASIP+F EFY E + N EG+ECLRLLNEIIADFDE+L++ F +EKIK+ G+
Sbjct: 601 DTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGS 660
Query: 354 TYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDAT 413
TYMAA+GL +VT +YA Q ++ F + +GK D
Sbjct: 661 TYMAATGL-----------NVTPGLEYAQYHDRQYMHIGTMVEFAFAL-VGKL----DVI 704
Query: 414 ASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDST 473
+ R+RV GIN GPV+AGVIGA+KPQYDIWGN VNVASRM+ST
Sbjct: 705 NKHSFNDFRMRV-------------GINHGPVIAGVIGAQKPQYDIWGNTVNVASRMEST 751
Query: 474 GLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
G+L IQVT+E IL GY CRG ++VKGKG++ T+F+
Sbjct: 752 GVLGKIQVTEETNWILQTLGYMCSCRGIINVKGKGDLRTFFV 793
Score = 43.6 bits (98), Expect = 0.019
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKL 496
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + ++ + L+ YK+
Sbjct: 145 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG-AYKV 201
>UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1085
Score = 228 bits (557), Expect = 5e-58
Identities = 116/202 (57%), Positives = 148/202 (73%), Gaps = 7/202 (3%)
Query: 208 QWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPE 267
+W I I + + L +H+QQ EST RLDFIW++QA +EKE+ME L+ YN KLL+NILP
Sbjct: 804 RWEAIIIIVMVVIILFVHAQQVESTARLDFIWRIQAQDEKEEMESLREYNLKLLSNILPL 863
Query: 268 HVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLN 327
HVA+HFL S KN D + LY+E ++V VMFASI NFSEFY+ELE NNEGVECLRLLN
Sbjct: 864 HVAKHFL-SMKN----DGK-LYYEDINNVGVMFASIVNFSEFYMELEANNEGVECLRLLN 917
Query: 328 EIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQ 387
EIIADFD +L + F +EKIK+ G TYM ASGLT+ T + + H+ A+ADY L+ Q
Sbjct: 918 EIIADFDTLLTHKRFFAVEKIKTVGQTYMCASGLTSRT-NFLDMTHILALADYTFALKNQ 976
Query: 388 LQYVNEHSFNCFRIRIGKSCSP 409
L+Y+NE+SFN F +RIG + P
Sbjct: 977 LEYINENSFNNFVMRIGLNIGP 998
Score = 115 bits (276), Expect = 5e-24
Identities = 58/88 (65%), Positives = 67/88 (76%), Gaps = 2/88 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIGPVVAGVIGA+KP YDIWGN VNVASRMDSTG + IQVT E+Y ILS Y L
Sbjct: 993 GLNIGPVVAGVIGAKKPHYDIWGNTVNVASRMDSTGEPNKIQVTAEMYRILSKNKYSLSP 1052
Query: 499 RGTVDVKGKGNMVTYFLEGV--GDSIPD 524
RG V VKGKG+M T+FL+ + G S+ D
Sbjct: 1053 RGLVRVKGKGDMHTFFLDAMPPGASLED 1080
Score = 48.0 bits (109), Expect = 9e-04
Identities = 47/202 (23%), Positives = 84/202 (41%), Gaps = 17/202 (8%)
Query: 206 NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL 265
+Q N+ I + V + E+ R F+ + M+ +LL ++L
Sbjct: 237 DQVVANVFIYICVNVIGVYFHYPMEAQQREAFLETRNCISVRLAMQKENQKQERLLLSVL 296
Query: 266 PEHVAQHF---LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
P HVA + +K F ++Y ++ D+V ++FA I F+ L E
Sbjct: 297 PRHVAMEMKADIAGNKKEAMF--HKIYIQRHDNVSILFADICGFTA----LSSTCTAQEL 350
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
++LLNE+ A FD + E + +IK G Y SG+ + +D H + L
Sbjct: 351 VQLLNELYARFDSLATE---NHCLRIKLLGDCYYCVSGMPDPRRD-----HAHCAVEMGL 402
Query: 383 RLREQLQYVNEHSFNCFRIRIG 404
+ E + V + + +R+G
Sbjct: 403 DMVEAIALVRDLTGTNVNMRVG 424
Score = 48.0 bits (109), Expect = 9e-04
Identities = 21/52 (40%), Positives = 32/52 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
GI+ G V GV+G K Q+D+W N V +A+ M+S GL H+ ++ D L+
Sbjct: 424 GIHSGRVHCGVLGLYKWQFDVWSNDVTLANHMESGGLPGHVHISSATKDYLN 475
>UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 3
SCAF13974, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1108
Score = 215 bits (525), Expect = 4e-54
Identities = 127/311 (40%), Positives = 177/311 (56%), Gaps = 35/311 (11%)
Query: 228 QTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFL------------- 274
Q E+ RLDF+W+LQA +E EDM L+ +N LL NILP HVAQHFL
Sbjct: 756 QLEAMARLDFLWRLQARKEVEDMRELREHNECLLLNILPAHVAQHFLERDRSNEVARLRL 815
Query: 275 --CSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIAD 332
C+ ++ AQELY + V V+FAS+P FS +Y + E + ECLRLLN II D
Sbjct: 816 SACTCAGVNLAFAQELYSQSYQRVGVLFASLPGFSRYYEQKEAADRHFECLRLLNHIITD 875
Query: 333 FDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLV----GYRHVTAMADYALRLREQL 388
FDE+L E F+ +EKIK+ G++YMAASGL+ Q + + H+ + +AL ++E L
Sbjct: 876 FDELLDESYFQDVEKIKTMGSSYMAASGLSPDRQSVQECEDAWHHLGELVLFALSMQETL 935
Query: 389 QYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAG 448
++N + N F++R+G D + P G+ GPV+AG
Sbjct: 936 SHINTDTGNSFQLRVG------DNNKKKRELMKALDSPP------LATSTGVAHGPVIAG 983
Query: 449 VIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKG-- 506
VIGA KPQYDIWG VN+ASRM+STG+ IQV + IL RG+ + RG++ +KG
Sbjct: 984 VIGATKPQYDIWGTTVNLASRMESTGISGMIQVPEATSCILVERGFLRQLRGSIYIKGIS 1043
Query: 507 --KGNMVTYFL 515
G + T+F+
Sbjct: 1044 ERHGKIRTFFV 1054
Score = 37.9 bits (84), Expect = 0.96
Identities = 14/37 (37%), Positives = 27/37 (72%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL 475
G++ G V+ GV+G +K Q+DIW V++A+ +++ G+
Sbjct: 403 GVHSGSVLCGVLGLQKWQFDIWSWDVDIANSLEAAGV 439
>UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8)
(Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=29; Euteleostomi|Rep: Adenylate
cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII)
(ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1251
Score = 206 bits (502), Expect = 2e-51
Identities = 105/214 (49%), Positives = 145/214 (67%), Gaps = 7/214 (3%)
Query: 195 YDYQHRCGLDW-NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHL 253
YD + G D+ + ++ + +A+ H QQ E T RLDF+W++QA EE +M+ L
Sbjct: 884 YDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKEL 943
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+ +N +L NILP HVA+HFL D+ D +ELY + D+V VMFASIP F++FY +
Sbjct: 944 REHNENMLRNILPSHVARHFLEKDR-----DNEELYSQSYDAVGVMFASIPGFADFYSQT 998
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YR 372
E NN+GVECLRLLNEIIADFDE+L E+ F+ IEKIK+ G+TYMA SGL+ Q +
Sbjct: 999 EMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWG 1058
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKS 406
H+ A+AD++L L E +Q +N+HSFN F +RIG S
Sbjct: 1059 HLCALADFSLALTESIQEINKHSFNNFELRIGIS 1092
Score = 93.9 bits (223), Expect = 1e-17
Identities = 53/106 (50%), Positives = 65/106 (61%), Gaps = 4/106 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQV +E Y IL +G+
Sbjct: 1090 GISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDY 1149
Query: 499 RGTVDVKG----KGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAV 540
RG + VKG +G + TYFL G P + +P S AV
Sbjct: 1150 RGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAV 1195
Score = 52.0 bits (119), Expect = 6e-05
Identities = 45/203 (22%), Positives = 83/203 (40%), Gaps = 16/203 (7%)
Query: 206 NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL 265
NQ + + A + S ++ R F+ + E + +E +L+ ++L
Sbjct: 319 NQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVL 378
Query: 266 PEHVAQHFLCSDKNIDQFDAQELYHE----QCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
P V + N++ Q +H + ++V ++FA + F+ L E
Sbjct: 379 PRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ----E 434
Query: 322 CLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
+R+LNE+ A FD + E + +IK G Y SGL QD H +
Sbjct: 435 LVRMLNELFARFDRLAHEH---HCLRIKILGDCYYCVSGLPEPRQD-----HAHCCVEMG 486
Query: 382 LRLREQLQYVNEHSFNCFRIRIG 404
L + + ++YV + + +RIG
Sbjct: 487 LSMIKTIRYVRSRTKHDVDMRIG 509
Score = 52.0 bits (119), Expect = 6e-05
Identities = 53/231 (22%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 323 LRLLNEIIADFDEILAEEPFK-YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
L ++N++ DE L + + YI + ++ + G TN + L V + +
Sbjct: 384 LEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELF 443
Query: 382 LRLREQLQYVNEHSFNCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGALIVRR- 435
R ++L H +C RI+I C + A+C + + + + R
Sbjct: 444 ARF-DRLA----HEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRS 498
Query: 436 -------VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
+ GI+ G V+ GV+G RK Q+D+W V++A++++S G+ I +++ D
Sbjct: 499 RTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDC 558
Query: 489 LSARGYKLRCRGTV--DVKGKGNMVTYFLEGVGD---SIPDDIYNNPIPST 534
L+ G + K N+ TY ++ D S+P+DI + S+
Sbjct: 559 LNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSS 609
>UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:
ENSANGP00000027378 - Anopheles gambiae str. PEST
Length = 2040
Score = 196 bits (477), Expect = 2e-48
Identities = 105/227 (46%), Positives = 145/227 (63%), Gaps = 8/227 (3%)
Query: 188 LYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEK 247
L + N F Y R ++A L +A+L H +Q E T RLDF+W+LQA++EK
Sbjct: 850 LSHANIFDCYDQRVESAIPLHTISVARILIFMIAILAHGRQVEWTARLDFLWQLQASQEK 909
Query: 248 EDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFS 307
++M LQ NR++L N+LP HVA HFL D + + +LYH+ V V+FAS+PNF
Sbjct: 910 KEMSVLQQSNRRILYNLLPSHVAAHFL--DNQFARSN-MDLYHQSYSKVGVIFASVPNFH 966
Query: 308 EFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
EFY EL+G+N+GVECLRLLNEIIADFDE+L EE F I+KIK+ G+TYMAA GL +
Sbjct: 967 EFYTELDGSNQGVECLRLLNEIIADFDELLCEERFHAIDKIKTVGSTYMAAVGLIPEHKM 1026
Query: 368 LVG-----YRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
L R +TA+ D+ +R L+ +NE+S+N F +R+G + P
Sbjct: 1027 LPSEPGSMRRLMTALVDFVKAMRVTLKNINENSYNNFMLRVGVNVGP 1073
Score = 125 bits (301), Expect = 5e-27
Identities = 56/77 (72%), Positives = 64/77 (83%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N+GPVVAGVIGARKPQYDIWGN VNVASRMDSTG+ + QVTQEV D L ++ RC
Sbjct: 1068 GVNVGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGIPGYTQVTQEVVDSLQGSHFEFRC 1127
Query: 499 RGTVDVKGKGNMVTYFL 515
RG + VKGKG+MVTYFL
Sbjct: 1128 RGQIKVKGKGDMVTYFL 1144
Score = 54.0 bits (124), Expect = 1e-05
Identities = 47/202 (23%), Positives = 86/202 (42%), Gaps = 12/202 (5%)
Query: 203 LDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLA 262
L + Q N+ I +G VA + + E R F+ + +ME +LL
Sbjct: 181 LAYQQLAANMVIFVGVNVAGFVVNVMMERAQRRAFLDTRNCIAARLEMEDENEKLERLLL 240
Query: 263 NILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
++LP+HVA + + ++Y ++ ++V ++FA I F+ L E
Sbjct: 241 SVLPQHVAMEMKNDILSPVEGQFHKIYIQKHENVSILFADIVGFT----VLASQCSAQEL 296
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+RLLNE+ FD++ + + +IK G Y SG+ + D H + L
Sbjct: 297 VRLLNELFGRFDQLAHD---NHCLRIKILGDCYYCVSGIPDPRAD-----HARCAVEMGL 348
Query: 383 RLREQLQYVNEHSFNCFRIRIG 404
+ + + V E + +R+G
Sbjct: 349 DMIDAIASVVEQTDVILNMRVG 370
Score = 52.8 bits (121), Expect = 3e-05
Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 13/109 (11%)
Query: 394 HSFNCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGAL--------IVRRVPAGI 440
H +C RI+I C D A A C + + ++ A+ ++ + GI
Sbjct: 312 HDNHCLRIKILGDCYYCVSGIPDPRADHARCAVEMGLDMIDAIASVVEQTDVILNMRVGI 371
Query: 441 NIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
+ G V+ GV+G RK Q+D+W N V +A+ M+S G + VT+ D L
Sbjct: 372 HSGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDAL 420
>UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC
4.6.1.1) (Adenylate cyclase type VIII) (ATP
pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Danio rerio|Rep: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase). - Danio rerio
Length = 888
Score = 195 bits (476), Expect = 3e-48
Identities = 100/191 (52%), Positives = 134/191 (70%), Gaps = 14/191 (7%)
Query: 223 LLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQ 282
L+ Q E T RLDF+W++QA EE +M L+ +N +L NILP HVA+HFL D+
Sbjct: 623 LVRMSQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDR---- 678
Query: 283 FDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPF 342
D +ELY + D+V VMFASIP F++FY + E NN+GVECLRLLNEIIADFDE+L EE F
Sbjct: 679 -DNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERF 737
Query: 343 KYIEKIKSTGATYMAASGLTNSTQD-LVG--------YRHVTAMADYALRLREQLQYVNE 393
+ IEKIK+ G+TYMA SGL N + ++G + H+ A+AD+A+ L E +Q +N+
Sbjct: 738 QDIEKIKTIGSTYMAVSGLLNVYRIWVIGMFKQCEDKWGHLCALADFAIALNESIQEINK 797
Query: 394 HSFNCFRIRIG 404
HSFN F++RIG
Sbjct: 798 HSFNNFQLRIG 808
Score = 89.0 bits (211), Expect = 4e-16
Identities = 44/81 (54%), Positives = 57/81 (70%), Gaps = 4/81 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQ+ +E Y IL+ RG+
Sbjct: 808 GMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEY 867
Query: 499 RGTVDVKG----KGNMVTYFL 515
RG + VKG +G + T+F+
Sbjct: 868 RGEIYVKGISEQEGKIRTHFM 888
Score = 49.6 bits (113), Expect = 3e-04
Identities = 43/197 (21%), Positives = 81/197 (41%), Gaps = 16/197 (8%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+ + L A + S ++ R F+ + E + +E +L+ ++LP V
Sbjct: 5 VLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVL 64
Query: 272 HFLCSDKNIDQFDAQELYHE----QCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLN 327
+ N++ Q +H + ++V ++FA + F+ L E +R+LN
Sbjct: 65 EMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ----ELVRMLN 120
Query: 328 EIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQ 387
E+ A FD + E + +IK G Y SGL D H + L + +
Sbjct: 121 ELFARFDRLAHEH---HCLRIKILGDCYYCVSGLPEPRPD-----HAHCCVEMGLSMIKT 172
Query: 388 LQYVNEHSFNCFRIRIG 404
++YV + + +RIG
Sbjct: 173 IRYVRSRTKHDIDMRIG 189
Score = 48.8 bits (111), Expect = 5e-04
Identities = 42/182 (23%), Positives = 82/182 (45%), Gaps = 19/182 (10%)
Query: 323 LRLLNEIIADFDEILAEEPFK-YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
L ++N++ DE L + + YI + ++ + G TN + L V + +
Sbjct: 64 LEMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELF 123
Query: 382 LRLREQLQYVNEHSFNCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGALIVRR- 435
R ++L H +C RI+I C + A+C + + + + R
Sbjct: 124 ARF-DRLA----HEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRS 178
Query: 436 -------VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
+ GI+ G V+ GV+G RK Q+D+W V++A++++S G+ I +++ D
Sbjct: 179 RTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDC 238
Query: 489 LS 490
L+
Sbjct: 239 LN 240
>UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate
cyclase; n=5; Coelomata|Rep: Ca(2+)/calmodulin-responsive
adenylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 2248
Score = 194 bits (473), Expect = 7e-48
Identities = 100/228 (43%), Positives = 147/228 (64%), Gaps = 11/228 (4%)
Query: 188 LYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEK 247
L ++N F Y +R ++A +A+L+H + E T RLDF+W+LQA++EK
Sbjct: 858 LSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEK 917
Query: 248 EDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQF-DAQELYHEQCDSVCVMFASIPNF 306
++M+ LQ N+++L N+LP HVA HFL + QF + ELYH+ V V+FAS+PNF
Sbjct: 918 KEMDVLQESNKRILHNLLPAHVAAHFLDA-----QFRNNMELYHQSYAKVGVIFASVPNF 972
Query: 307 SEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL----- 361
+EFY E++G+++G+ECLRLLNEIIADFDE+L E+ F+ I+KIK+ G+TYMA GL
Sbjct: 973 NEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYK 1032
Query: 362 TNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
RH+TA+ +Y +R LQ +N HS+N F +R+G + P
Sbjct: 1033 IQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGP 1080
Score = 127 bits (306), Expect = 1e-27
Identities = 62/91 (68%), Positives = 72/91 (79%), Gaps = 1/91 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GINIGPVVAGVIGARKPQYDIWGN VNVASRMDSTG+ + QVTQEV D L ++ RC
Sbjct: 1075 GINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRC 1134
Query: 499 RGTVDVKGKGNMVTYFLEGVGD-SIPDDIYN 528
RGT+ VKGKG+MVTYFL G+ S+ ++ N
Sbjct: 1135 RGTIKVKGKGDMVTYFLCDSGNKSLNGEVRN 1165
Score = 58.0 bits (134), Expect = 8e-07
Identities = 49/202 (24%), Positives = 87/202 (43%), Gaps = 12/202 (5%)
Query: 203 LDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLA 262
L++NQ NI I +G VA L+ + E R F+ + +++ +LL
Sbjct: 181 LEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLL 240
Query: 263 NILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
++LP+HVA + +Y ++ ++V ++FA I F+ L E
Sbjct: 241 SVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTV----LSSQCSAQEL 296
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+RLLNE+ FD++ + + +IK G Y SGL +D H + L
Sbjct: 297 VRLLNELFGRFDQLAHD---NHCLRIKILGDCYYCVSGLPEPRKD-----HAKCAVEMGL 348
Query: 383 RLREQLQYVNEHSFNCFRIRIG 404
+ + + V E + +R+G
Sbjct: 349 DMIDAIATVVEATDVILNMRVG 370
Score = 51.6 bits (118), Expect = 7e-05
Identities = 23/59 (38%), Positives = 36/59 (61%)
Query: 432 IVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
++ + GI+ G V+ GV+G RK Q+D+W N V +A+ M+S G + VT+ D LS
Sbjct: 363 VILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLS 421
>UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 781
Score = 192 bits (469), Expect = 2e-47
Identities = 94/193 (48%), Positives = 137/193 (70%), Gaps = 10/193 (5%)
Query: 221 ALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD-KN 279
+L LHS+Q + RLD++W +QA EE++DME ++ N+++L N+LP HVAQHFL S+ +N
Sbjct: 517 SLALHSRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRN 576
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+D LY++ V VMFASIPNF++FY+EL+GNN GVECLRLLNEIIADFDE++ +
Sbjct: 577 MD------LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEK 630
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVG---YRHVTAMADYALRLREQLQYVNEHSF 396
E +K IEKIK+ G+TYM A GL +T Y H++ +AD+++ + + L +N S+
Sbjct: 631 ECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSY 690
Query: 397 NCFRIRIGKSCSP 409
N F +R+G + P
Sbjct: 691 NEFVLRVGINVGP 703
Score = 125 bits (302), Expect = 4e-27
Identities = 57/79 (72%), Positives = 66/79 (83%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT++V+ IL + Y+ C
Sbjct: 698 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVC 757
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M+TYFLEG
Sbjct: 758 RGKVSVKGKGEMLTYFLEG 776
Score = 48.8 bits (111), Expect = 5e-04
Identities = 20/52 (38%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+ + L+
Sbjct: 96 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLN 147
Score = 35.9 bits (79), Expect = 3.9
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
++FA I F+ L E ++LLNE+ FDE+ E + +IK G Y
Sbjct: 2 ILFADIVGFTS----LASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYC 54
Query: 358 ASGLTNSTQD 367
SGLT D
Sbjct: 55 VSGLTQPKTD 64
>UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=2;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 953
Score = 192 bits (469), Expect = 2e-47
Identities = 94/193 (48%), Positives = 137/193 (70%), Gaps = 10/193 (5%)
Query: 221 ALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD-KN 279
+L LHS+Q + RLD++W +QA EE++DME ++ N+++L N+LP HVAQHFL S+ +N
Sbjct: 689 SLALHSRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRN 748
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+D LY++ V VMFASIPNF++FY+EL+GNN GVECLRLLNEIIADFDE++ +
Sbjct: 749 MD------LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEK 802
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVG---YRHVTAMADYALRLREQLQYVNEHSF 396
E +K IEKIK+ G+TYM A GL +T Y H++ +AD+++ + + L +N S+
Sbjct: 803 ECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSY 862
Query: 397 NCFRIRIGKSCSP 409
N F +R+G + P
Sbjct: 863 NEFVLRVGINVGP 875
Score = 125 bits (302), Expect = 4e-27
Identities = 57/79 (72%), Positives = 66/79 (83%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT++V+ IL + Y+ C
Sbjct: 870 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVC 929
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M+TYFLEG
Sbjct: 930 RGKVSVKGKGEMLTYFLEG 948
Score = 52.4 bits (120), Expect = 4e-05
Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQEL 288
TE R F+ E++ +E +LL ++LP +VA + ++
Sbjct: 83 TERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKI 142
Query: 289 YHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKI 348
Y ++ D+V ++FA I F+ L E ++LLNE+ FDE+ E + +I
Sbjct: 143 YIQRHDNVSILFADIVGFTS----LASQCTAQELVKLLNELFGKFDELATE---NHCRRI 195
Query: 349 KSTGATYMAASGLTNSTQD 367
K G Y SGLT D
Sbjct: 196 KILGDCYYCVSGLTQPKTD 214
Score = 48.8 bits (111), Expect = 5e-04
Identities = 20/52 (38%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+ + L+
Sbjct: 246 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLN 297
>UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=27; Euteleostomi|Rep: Adenylate
cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I)
(ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1119
Score = 192 bits (469), Expect = 2e-47
Identities = 100/202 (49%), Positives = 143/202 (70%), Gaps = 11/202 (5%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+AI L + AL LH++Q + RLD++W QA EE+EDME ++ NR++L N+LP HVAQ
Sbjct: 789 VAILL-FSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQ 847
Query: 272 HFLCSD-KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
HFL S+ +N+D LY++ V VMFASIPNF++FY+EL+GNN GVECLRLLNEII
Sbjct: 848 HFLMSNPRNMD------LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEII 901
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGL--TNSTQDLVGY-RHVTAMADYALRLREQ 387
ADFDE++ ++ +K IEKIK+ G+TYMAA GL T+ T+ H++ +AD+A+ + +
Sbjct: 902 ADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDV 961
Query: 388 LQYVNEHSFNCFRIRIGKSCSP 409
L +N S+N F +R+G + P
Sbjct: 962 LDEINYQSYNDFVLRVGINVGP 983
Score = 124 bits (298), Expect = 1e-26
Identities = 58/82 (70%), Positives = 65/82 (79%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT+EV+ +L Y C
Sbjct: 978 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC 1037
Query: 499 RGTVDVKGKGNMVTYFLEGVGD 520
RG V VKGKG M+TYFLEG D
Sbjct: 1038 RGKVSVKGKGEMLTYFLEGRTD 1059
Score = 53.6 bits (123), Expect = 2e-05
Identities = 41/163 (25%), Positives = 69/163 (42%), Gaps = 7/163 (4%)
Query: 205 WNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANI 264
W N + +G + + TE + R F+ E++ +E +LL ++
Sbjct: 211 WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSL 270
Query: 265 LPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLR 324
LP +VA + ++Y ++ D+V ++FA I F+ L E ++
Sbjct: 271 LPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTG----LASQCTAQELVK 326
Query: 325 LLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
LLNE+ FDE+ E + +IK G Y SGLT D
Sbjct: 327 LLNELFGKFDELATE---NHCRRIKILGDCYYCVSGLTQPKTD 366
Score = 47.6 bits (108), Expect = 0.001
Identities = 19/45 (42%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+
Sbjct: 398 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITK 442
>UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain adenylate
cyclase 1; n=1; Canis lupus familiaris|Rep: PREDICTED:
similar to brain adenylate cyclase 1 - Canis familiaris
Length = 1161
Score = 191 bits (466), Expect = 5e-47
Identities = 92/189 (48%), Positives = 134/189 (70%), Gaps = 7/189 (3%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD-KNI 280
L LH++Q + RLD++W QA EE++DME ++ N+++L N+LP HVAQHFL S+ +N+
Sbjct: 831 LALHARQVDVKLRLDYLWTAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNM 890
Query: 281 DQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEE 340
D LY++ V VMFASIPNF +FY+EL+GNN GVECLRLLNEIIADFDE++ ++
Sbjct: 891 D------LYYQSYSQVGVMFASIPNFDDFYIELDGNNMGVECLRLLNEIIADFDELMDKD 944
Query: 341 PFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFR 400
+K +EKIK+ G+TYMAA GL +T H++ +AD+A+ + + L +N S+N F
Sbjct: 945 FYKDLEKIKTIGSTYMAAVGLAPTTGTKCISSHLSTLADFAIEMFDVLDEINYQSYNDFV 1004
Query: 401 IRIGKSCSP 409
+R+G + P
Sbjct: 1005 LRVGINVGP 1013
Score = 125 bits (302), Expect = 4e-27
Identities = 58/82 (70%), Positives = 66/82 (80%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT+EV+ +L Y+ C
Sbjct: 1008 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRGTYRFVC 1067
Query: 499 RGTVDVKGKGNMVTYFLEGVGD 520
RG V VKGKG M+TYFLEG D
Sbjct: 1068 RGKVSVKGKGEMLTYFLEGRTD 1089
Score = 47.6 bits (108), Expect = 0.001
Identities = 19/45 (42%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+
Sbjct: 323 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITR 367
Score = 35.9 bits (79), Expect = 3.9
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 293 CDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTG 352
C + ++FA I F+ L E ++LLNE+ FDE+ E + +IK G
Sbjct: 224 CAWLRILFADIVGFTG----LASQCTAQELVKLLNELFGKFDELATE---NHCRRIKILG 276
Query: 353 ATYMAASGLTNSTQD 367
Y SGLT D
Sbjct: 277 DCYYCVSGLTQPKTD 291
>UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl
cyclase 78C CG10564-PA; n=2; Apocrita|Rep: PREDICTED:
similar to Adenylyl cyclase 78C CG10564-PA - Apis
mellifera
Length = 1299
Score = 185 bits (450), Expect = 4e-45
Identities = 99/192 (51%), Positives = 125/192 (65%), Gaps = 10/192 (5%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
V + H + E T RLDF+WK QA E DM + N +LL NILP+HVA HFL D+
Sbjct: 1003 VMVTYHGRLVEVTSRLDFLWKQQAERELSDMIESRHNNMQLLKNILPDHVAHHFLTQDR- 1061
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
A ELY + D V VMFAS+PNF+EFY E N+G+EC+RLLNEIIADFDE+L E
Sbjct: 1062 -----APELYSQSRDKVGVMFASVPNFTEFYSE--DVNKGMECIRLLNEIIADFDELLDE 1114
Query: 340 EPFKYIEKIKSTGATYMAASGLT--NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
F IEKIK+ GATYMAASGL + ++ H+ + DYA+ +R +L+ VN HSFN
Sbjct: 1115 NRFHCIEKIKTVGATYMAASGLNPCQNDKNKDDMEHLCRLVDYAVAMRLRLEDVNIHSFN 1174
Query: 398 CFRIRIGKSCSP 409
F +R+G SC P
Sbjct: 1175 NFDLRVGISCGP 1186
Score = 109 bits (263), Expect = 2e-22
Identities = 49/81 (60%), Positives = 63/81 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GP+V GVIGARKP +DIWGN VN+ASRMDSTG++ IQV Q++ L +RGY+ +
Sbjct: 1181 GISCGPLVGGVIGARKPVFDIWGNTVNLASRMDSTGVMGKIQVPQDIARFLESRGYQTQK 1240
Query: 499 RGTVDVKGKGNMVTYFLEGVG 519
RG ++VKGKG M TYF+ G G
Sbjct: 1241 RGLIEVKGKGTMETYFVLGKG 1261
Score = 44.8 bits (101), Expect = 0.008
Identities = 17/52 (32%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
GI+ G V+ GV+G RK Q+D+W V +A+ ++S G+ + ++++ + L+
Sbjct: 479 GIHSGSVLCGVLGLRKWQFDVWSYDVTLANHLESGGIPGRVHISEDTLNCLN 530
Score = 41.1 bits (92), Expect = 0.10
Identities = 38/167 (22%), Positives = 74/167 (44%), Gaps = 16/167 (9%)
Query: 210 TNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHV 269
TN+ + L +A + T+ R F+ ++ E ++ ++ KLL ++LP+ V
Sbjct: 288 TNVLLYLAMNLAGMYTKYLTDRGQRQAFLETHRSMETRQRTQNENNRQEKLLLSVLPDFV 347
Query: 270 AQHFL------CSDKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
A+ + + F + +Y + ++V ++FA I F+ L
Sbjct: 348 AKEMIRDIARETARGGTISFTPNQFHRIYIHRYENVSILFADIKGFT----ALASQCSAQ 403
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
E +++LN++ A FD++ AE + +IK G Y GL + D
Sbjct: 404 ELVKVLNDLFARFDKLSAE---NHCLRIKLLGDCYYCICGLPIARSD 447
>UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG10564-PA - Tribolium castaneum
Length = 1551
Score = 185 bits (450), Expect = 4e-45
Identities = 97/188 (51%), Positives = 130/188 (69%), Gaps = 12/188 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFD 284
H++ E T RLDF+WK QA E DME + N +LL NILP+HVAQHFL +++N
Sbjct: 1052 HARLVEVTSRLDFLWKQQAERELNDMEETRHTNTQLLKNILPDHVAQHFLSNERN----- 1106
Query: 285 AQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
++ELY + + V V+FASIPNF+EFY E N+G+EC+RLLNEIIADFDE+L EE F
Sbjct: 1107 SEELYSQSREEVGVLFASIPNFTEFY--SEDINKGLECIRLLNEIIADFDELLDEERFSM 1164
Query: 345 IEKIK--STGATYMAASGLTNSTQDLVGY---RHVTAMADYALRLREQLQYVNEHSFNCF 399
IEKIK S ATYMAASGL + +D + H+ A+ D+A+ +R++L +N+ SFN F
Sbjct: 1165 IEKIKTVSATATYMAASGLNPTHKDALNTDSPEHLCALIDFAIAMRQKLDEINKESFNNF 1224
Query: 400 RIRIGKSC 407
+R+G SC
Sbjct: 1225 GLRVGVSC 1232
Score = 103 bits (248), Expect = 1e-20
Identities = 47/92 (51%), Positives = 61/92 (66%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G +V GVIGARKP +DIWGN VN ASRMDSTG++ IQV + +L RGY+++
Sbjct: 1229 GVSCGSLVCGVIGARKPVFDIWGNTVNEASRMDSTGVIGQIQVPKYTAQLLGVRGYEVKK 1288
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNP 530
RG ++VKGKG M TYF+ G P P
Sbjct: 1289 RGIIEVKGKGQMETYFVMGRQQGRPPSFQRQP 1320
Score = 45.2 bits (102), Expect = 0.006
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N + + A + T+ + R F+ ++ E + + KLL ++LP+ VA
Sbjct: 299 NFLLYVAVNFAGMYTKYLTDRSQRKAFLETHRSMETRYRTQSENDKQEKLLLSVLPDFVA 358
Query: 271 QHFLCSDKNIDQ------FDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLR 324
+ + + ++ ++Y + ++V ++FA I F+ L E +R
Sbjct: 359 KEMIRDIEREERGGVFQPHQFHKIYIHRYENVSILFADIKGFTA----LASQCSAQELVR 414
Query: 325 LLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
+LNE+ A FD++ AE + +IK G Y SGL D
Sbjct: 415 ILNELFARFDKLAAE---NHCLRIKLLGDCYYCVSGLPTPRSD 454
Score = 44.0 bits (99), Expect = 0.015
Identities = 19/52 (36%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
GI+ G V+ GV+G RK Q+DI+ V +A+ M+S G+ + +++ Y L+
Sbjct: 486 GIHSGSVLCGVLGLRKWQFDIFSYDVRLANHMESGGIPGRVHISEATYQCLN 537
>UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep:
Adenylate cyclase - Aplysia californica (California sea
hare)
Length = 1339
Score = 185 bits (450), Expect = 4e-45
Identities = 93/191 (48%), Positives = 129/191 (67%), Gaps = 10/191 (5%)
Query: 224 LHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQF 283
L +++ E T RLDF+WK QA EEK M+ LQ N ++L N+LPEHVA HFL N
Sbjct: 835 LQNREQEWTLRLDFLWKSQAAEEKAGMQELQRQNSRILCNLLPEHVANHFLHLQTN---- 890
Query: 284 DAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFK 343
ELY +Q + V V FASIPNFS+FYVEL NN+GVECLR+LNEIIADFDE+L F
Sbjct: 891 SHMELYSQQYNKVAVFFASIPNFSDFYVELAANNQGVECLRVLNEIIADFDELLDIPYFY 950
Query: 344 YIEKIKSTGATYMAASG-----LTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+EKIK+ G+ YMAA+G L +D + + ++T + D+ + ++E+L+ +NE+S+N
Sbjct: 951 GVEKIKTIGSCYMAATGLKPTHLVKGREDSITF-YLTMLVDFVMSMKEKLKNINENSYNN 1009
Query: 399 FRIRIGKSCSP 409
F +R+G + P
Sbjct: 1010 FELRVGINVGP 1020
Score = 121 bits (291), Expect = 8e-26
Identities = 73/135 (54%), Positives = 84/135 (62%), Gaps = 7/135 (5%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGARKPQYDIWGN VNVASRM+STG+ IQVT+EVY +L + + C
Sbjct: 1015 GINVGPVVAGVIGARKPQYDIWGNTVNVASRMESTGVSSKIQVTEEVYAVLKS-VFTFEC 1073
Query: 499 RGTVDVKGKGNMVTYFL-EGVGDSIPDDIYNNPIPSTSS--EGAVPPR--PEHRPLDTLS 553
RG V VKGKG+M+TYFL E P I+ P P S G+ R E PL S
Sbjct: 1074 RGKVPVKGKGDMITYFLRERRRPRDPSCIFPPPTPPESPMVNGSSSTRRSAESLPLTAPS 1133
Query: 554 EAHTDEDGGPSPRAS 568
A D S RAS
Sbjct: 1134 AAAVTPDPS-SKRAS 1147
Score = 52.4 bits (120), Expect = 4e-05
Identities = 43/164 (26%), Positives = 68/164 (41%), Gaps = 7/164 (4%)
Query: 198 QHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYN 257
+H L W Q N + L A VA L T+ T R F + D++
Sbjct: 200 RHFPDLHWRQLVANTILFLCANVAGLFTHNSTDRTQRRTFKDTRDCIAARLDIQDQNEKL 259
Query: 258 RKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNN 317
++L ++LP+HVA ++Y + D+V ++FA I F+ L
Sbjct: 260 ERILMSVLPQHVAMEMKNDITTPHHGMFHKIYIQLHDNVTILFADIVGFTC----LSSQC 315
Query: 318 EGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
E +R+LNE+ FD++ + +IK G Y SGL
Sbjct: 316 TAQELVRILNELFGRFDQLAKQ---NNCMRIKILGDCYYCVSGL 356
Score = 47.2 bits (107), Expect = 0.002
Identities = 29/106 (27%), Positives = 54/106 (50%), Gaps = 13/106 (12%)
Query: 397 NCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGAL--------IVRRVPAGINIG 443
NC RI+I C +A A+ A C + + ++ A+ + + G++ G
Sbjct: 339 NCMRIKILGDCYYCVSGLPEARANHAACCVEMGLDMIDAIASVCDQTGVKLNMRVGLHTG 398
Query: 444 PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
V+ GV+G +K QYD++ N V +A+ M++ G+ + +T+ D L
Sbjct: 399 RVLCGVLGLKKWQYDVFSNDVKLANHMEAGGIAGRVHITKSTLDQL 444
>UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 8 SCAF9864, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 879
Score = 182 bits (443), Expect = 3e-44
Identities = 92/197 (46%), Positives = 131/197 (66%), Gaps = 12/197 (6%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+ LL+ ++Q E RLDF+WK + +E E++E ++ NR LL N+LP HVA+HFL +
Sbjct: 603 ITLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARN-- 660
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+ ++LYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLNEIIADFDE+L++
Sbjct: 661 ---WKNEDLYHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSK 717
Query: 340 EPFKYIEKIKSTGATYMAASGLT-------NSTQDLVGYRHVTAMADYALRLREQLQYVN 392
F +EKIK+ G+TYMAA+GL S + Y H+ M ++A L +L +N
Sbjct: 718 PKFSGVEKIKTIGSTYMAATGLNASPGPEHASQEHDRQYMHIGTMVEFAFALVGKLDVIN 777
Query: 393 EHSFNCFRIRIGKSCSP 409
+HSFN F++R+G + P
Sbjct: 778 KHSFNDFKLRVGINHGP 794
Score = 115 bits (277), Expect = 4e-24
Identities = 52/81 (64%), Positives = 63/81 (77%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GIN GPV+AGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E IL GY
Sbjct: 785 KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETSRILQTLGY 844
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
CRG ++VKGKG + TYF+
Sbjct: 845 MCSCRGIINVKGKGELKTYFV 865
Score = 45.2 bits (102), Expect = 0.006
Identities = 20/58 (34%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKL 496
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + +T + L+ YK+
Sbjct: 324 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNG-AYKV 380
>UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 2 -
Caenorhabditis elegans
Length = 1080
Score = 182 bits (443), Expect = 3e-44
Identities = 116/309 (37%), Positives = 172/309 (55%), Gaps = 26/309 (8%)
Query: 212 IAIALGATVALLLHSQQ-TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
++I+L V LL T + + + E+ D+E +Q N+ L+ NILP VA
Sbjct: 768 VSISLSLLVVLLFFIDWITNYERKRESACHVSFQNEERDVETMQDINKILIENILPSSVA 827
Query: 271 QHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
FL D+ ++ ELY Q ++VCVMFASIPNF +F+ E + N + +ECLRLLNEI+
Sbjct: 828 AKFLSPDRAVN-----ELYARQHENVCVMFASIPNFKDFWSEWDTNRK-LECLRLLNEIV 881
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YRHVTAMADYALRLRE-QL 388
+FD++L++ F +EKIK+ G+TYMAA+GL S D Y Y +R +
Sbjct: 882 CEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRHGNM 941
Query: 389 QYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAG 448
+ N + F + + + + S N LR+ G+++GP+VAG
Sbjct: 942 AFRNANLMIEFALAMSQILDALNRD-SFQNFELRI---------------GMSVGPLVAG 985
Query: 449 VIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKG-K 507
VIGA+KPQYDIWGN VN+ASRMD+ G I T ++ +L GY+++ RG + VKG K
Sbjct: 986 VIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVK 1045
Query: 508 GNMVTYFLE 516
M T+ +E
Sbjct: 1046 EPMETFLIE 1054
Score = 49.6 bits (113), Expect = 3e-04
Identities = 24/72 (33%), Positives = 43/72 (59%), Gaps = 3/72 (4%)
Query: 418 NCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLD 477
N +VR+ G + +R G++ G V+ G++G RK Q+DIW + V +A+ M+S G+
Sbjct: 391 NTIKQVRIATGVDVNMR---IGVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPG 447
Query: 478 HIQVTQEVYDIL 489
+ +T+ D+L
Sbjct: 448 AVHITKSTKDML 459
>UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=7; Clupeocephala|Rep: Chromosome 14
SCAF15003, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1077
Score = 180 bits (437), Expect = 2e-43
Identities = 92/191 (48%), Positives = 128/191 (67%), Gaps = 6/191 (3%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
VA+ + +Q E+T RLDF+W+LQA +E EDM L+ +N LL NILP HVA+HFL KN
Sbjct: 775 VAVFYNGRQWEATARLDFLWRLQAQQEVEDMRELREHNECLLYNILPVHVARHFLDRSKN 834
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+ELY + D V VMFASI F+E++ + E +EGV+CLRLLNEIIA FDE+L E
Sbjct: 835 -----DEELYSQSYDEVGVMFASIAGFNEYFEQKEIKHEGVDCLRLLNEIIAGFDELLEE 889
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQ-DLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
F Y+EKIK+ G+ YMAASGL Q + + H++ + +AL ++E L+ +N HS
Sbjct: 890 SYFSYVEKIKTIGSCYMAASGLAPDRQVSMDEWNHLSELVLFALAMQETLKEINRHSTKN 949
Query: 399 FRIRIGKSCSP 409
F++R+G + P
Sbjct: 950 FQLRVGIAHGP 960
Score = 89.0 bits (211), Expect = 4e-16
Identities = 46/81 (56%), Positives = 56/81 (69%), Gaps = 4/81 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI GPVVAGVIGA KPQYDIWG+ VN+ASRMDSTG+ IQV + IL+ G+ L
Sbjct: 955 GIAHGPVVAGVIGATKPQYDIWGSTVNLASRMDSTGVSGRIQVPEATKKILTEWGFVLEL 1014
Query: 499 RGTVDVKG----KGNMVTYFL 515
RG + VKG +G + TYF+
Sbjct: 1015 RGEIFVKGVSERQGKVRTYFI 1035
Score = 41.9 bits (94), Expect = 0.059
Identities = 17/51 (33%), Positives = 32/51 (62%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GI+ G V+ GV+G +K Q+D+W V +A+ +++ G+ I +++ D L
Sbjct: 397 GIHSGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDCL 447
>UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000010056 - Anopheles gambiae
str. PEST
Length = 881
Score = 176 bits (429), Expect = 2e-42
Identities = 88/192 (45%), Positives = 123/192 (64%), Gaps = 7/192 (3%)
Query: 220 VALLLHSQQTESTY--RLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD 277
++ +LH+ + Y R DF+WK + E+E++E ++ N+ LL NILP HVAQHFL +
Sbjct: 623 ISAVLHTLDRQGEYAARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKE 682
Query: 278 KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEIL 337
+ + QELYHE SV VMFASIPN+ EFY E + N +G+ECLRLLNEII DFD++L
Sbjct: 683 RAV-----QELYHESYSSVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLL 737
Query: 338 AEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
+ F IEKIK+ G+TYM ASGL ++ +V + ++A+ L L +N SF
Sbjct: 738 LKPKFSGIEKIKTIGSTYMIASGLRPGKEEGATEHNVVVLVEFAIALMTALDQINRESFQ 797
Query: 398 CFRIRIGKSCSP 409
FR+RIG + P
Sbjct: 798 RFRLRIGLNHGP 809
Score = 110 bits (264), Expect = 1e-22
Identities = 48/82 (58%), Positives = 61/82 (74%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPV+AGVIGA+KPQYDIW N VNVASRMDS G++ +QVT+ +L A GY
Sbjct: 800 RLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRVQVTENTAKVLMAAGY 859
Query: 495 KLRCRGTVDVKGKGNMVTYFLE 516
CRG + VKGKG + TYF++
Sbjct: 860 SCDCRGPIHVKGKGILTTYFVK 881
Score = 49.2 bits (112), Expect = 4e-04
Identities = 20/51 (39%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GI+ G V+ GV+G RK Q+D+W + V +A+ M+S G+ + +T+ D L
Sbjct: 229 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKATLDYL 279
>UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC
4.6.1.1) (Adenylate cyclase type VIII) (ATP
pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=4;
Clupeocephala|Rep: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase). - Takifugu rubripes
Length = 1020
Score = 175 bits (425), Expect = 5e-42
Identities = 121/402 (30%), Positives = 206/402 (51%), Gaps = 28/402 (6%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLL--AFNMTPIGIATMILCGIIVVSVTYLIFA 72
+Y+ RD + K CS ++ ++ VQ+L A + P+ + +++ G + + L
Sbjct: 569 KYSQMRDELFKSNIVCSFILSLLLMAVQVLIPAPRIFPM-VVLVLVSGCVYSMLLVLTLG 627
Query: 73 IDLKFAGGKLKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVPSYE 132
+ K L+ + +H N L+ + ++ I V + + NN++ P
Sbjct: 628 EEFKRCPPPLQSLCCWIHENEFTRTLVMLTAI-SINFGIATVDIVSRTSIHNNSSDPFLA 686
Query: 133 NSGGNCP-YDMNEH--YLQVT-LMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXXQEHL 188
P ++ H Y+ ++ +++M CAV + + H
Sbjct: 687 PPTSTWPAVNICTHPEYMVLSGVVSMVTCAVF-LRLRCVLKLVILLLATMLYTFLIETH- 744
Query: 189 YYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKE 248
R+H + C + + L A+L +S+ E+ RLDF+W+LQA +E E
Sbjct: 745 --RSHQLCTKGIC----------VILMLMFVTAVLYNSRTLEAMARLDFLWRLQARKEVE 792
Query: 249 DMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSE 308
DM L+ +N LL NILP HVAQHFL D+N +ELY + + V V+FAS+P FS+
Sbjct: 793 DMRELREHNECLLLNILPAHVAQHFLERDRN-----NEELYSQSYERVGVLFASLPGFSD 847
Query: 309 FYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDL 368
+Y + E ++ CLRLLN II DFDE+L E F+ +EKIK+ G++YMAASGL+ Q+
Sbjct: 848 YYEQKEAADQHFGCLRLLNHIITDFDELLDESYFQDVEKIKTMGSSYMAASGLSPDRQEC 907
Query: 369 V-GYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
G+ H++ + +AL ++E L+++N + N F++R+G + P
Sbjct: 908 EDGWHHLSELVLFALSMQETLKHINTDTGNSFQLRVGIAHGP 949
Score = 84.2 bits (199), Expect = 1e-14
Identities = 41/68 (60%), Positives = 49/68 (72%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI GPV+AGVIGA KPQYDIWG VNVASRM+STG+ IQV + IL RG+ +
Sbjct: 944 GIAHGPVIAGVIGATKPQYDIWGTTVNVASRMESTGVSGMIQVPESTSCILVERGFLRQL 1003
Query: 499 RGTVDVKG 506
RG++ VKG
Sbjct: 1004 RGSIFVKG 1011
Score = 42.3 bits (95), Expect = 0.045
Identities = 16/51 (31%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G +K Q+DIW V++A+ +++ G+ + +++ D L
Sbjct: 390 GVHSGSVLCGVLGLQKWQFDIWSWDVDIANSLEAAGVPGRVHISRATLDCL 440
>UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 4 -
Caenorhabditis elegans
Length = 954
Score = 174 bits (424), Expect = 6e-42
Identities = 95/206 (46%), Positives = 129/206 (62%), Gaps = 12/206 (5%)
Query: 209 WTNIAIALGATVALLLHS-QQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPE 267
+ N + T+ L++ S +++E R DFIWKLQA +E+ M+ NR +L NILP
Sbjct: 673 YANFCVLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPS 732
Query: 268 HVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLN 327
HVA+HF+ D +LYHE D+ C+MFA++ F +FY+E +GNNEGVECLRLLN
Sbjct: 733 HVAKHFV-----EDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLN 787
Query: 328 EIIADFDEILAE----EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALR 383
EII+DFD+IL + E FK IEKIK+ TYM ASGL ++ HV A+A +A
Sbjct: 788 EIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAG--RECGDNSHVEAIALFARE 845
Query: 384 LREQLQYVNEHSFNCFRIRIGKSCSP 409
L +L+ N HSFN F +RIG + P
Sbjct: 846 LLVKLESTNIHSFNNFNLRIGINVGP 871
Score = 114 bits (274), Expect = 9e-24
Identities = 52/77 (67%), Positives = 60/77 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIG+ KP YDIWGN+VNVASRMDS G+ IQVT+EV IL GY C
Sbjct: 866 GINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFEC 925
Query: 499 RGTVDVKGKGNMVTYFL 515
RG ++VKGKG M T+FL
Sbjct: 926 RGQINVKGKGMMETFFL 942
Score = 45.6 bits (103), Expect = 0.005
Identities = 18/44 (40%), Positives = 29/44 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
GI+ G GV+G +K Q+D+W N V +A++M+S GL + +T
Sbjct: 338 GIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHIT 381
>UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73;
Euteleostomi|Rep: Adenylate cyclase type 4 - Homo
sapiens (Human)
Length = 1077
Score = 174 bits (423), Expect = 8e-42
Identities = 88/194 (45%), Positives = 128/194 (65%), Gaps = 11/194 (5%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+ ++
Sbjct: 803 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-- 860
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
++LYH+ + VCV+FAS+P+F EFY E N+EG+ECLRLLNEIIADFDE+L++
Sbjct: 861 ---NEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 917
Query: 342 FKYIEKIKSTGATYMAASGL-TNSTQDLV-----GYRHVTAMADYALRLREQLQYVNEHS 395
F +EKIK+ G+TYMAA+GL S QD H+ M ++A+ L +L +N+HS
Sbjct: 918 FSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHS 977
Query: 396 FNCFRIRIGKSCSP 409
FN FR+R+G + P
Sbjct: 978 FNNFRLRVGLNHGP 991
Score = 110 bits (265), Expect = 1e-22
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 982 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 1041
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 1042 TCYSRGVIKVKGKGQLCTYFL 1062
Score = 44.8 bits (101), Expect = 0.008
Identities = 18/52 (34%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + +T +L+
Sbjct: 368 GVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 419
Score = 38.3 bits (85), Expect = 0.73
Identities = 42/167 (25%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N + L VA + H E R F L + + ++ + + LL +ILP ++A
Sbjct: 177 NAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA 236
Query: 271 QHF---LCSDKNIDQFDAQE-------LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
+ + + Q E LY ++ V V++A I F+ E
Sbjct: 237 REMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPK---- 292
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
E + +LNE+ FD+I E +IK G Y SGL S D
Sbjct: 293 ELVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYCVSGLPLSLPD 336
>UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate
cyclase 2; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Adenylate cyclase 2 -
Strongylocentrotus purpuratus
Length = 889
Score = 173 bits (422), Expect = 1e-41
Identities = 87/195 (44%), Positives = 134/195 (68%), Gaps = 13/195 (6%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
V L+L ++ E T RL F+W+++ E+E++E +++ N+ LL N+LP HVAQHF
Sbjct: 614 VMLVLIDRRIEYTARLGFLWQMKYRVEREEVETMESLNKVLLENMLPSHVAQHF------ 667
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
+ Q +LYH+ + + VMFASIPNF EFY E + NNEG+ECLRLLNEIIADFDE+L++
Sbjct: 668 VKQRMKSDLYHQSYNLIAVMFASIPNFKEFYTETDVNNEGLECLRLLNEIIADFDELLSK 727
Query: 340 EPFKYIEKIKSTGATYMAASGLTN-----STQDLVGYRHVTAMADYALRLREQLQYVNEH 394
+ +EKIK+ G+TYM+A+GL ST+ + Y V + ++A+ L+++L+ +N+
Sbjct: 728 PKYSCVEKIKTIGSTYMSAAGLKQPESGVSTKQSLYY--VGVLTEFAMALQDKLEQLNKQ 785
Query: 395 SFNCFRIRIGKSCSP 409
+FN F++RIG + P
Sbjct: 786 AFNDFKLRIGINHGP 800
Score = 111 bits (267), Expect = 6e-23
Identities = 51/84 (60%), Positives = 62/84 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPVVAGVIGARKPQYDIWGN VNVASRMD+TG++ IQVT+E ++L G+
Sbjct: 795 GINHGPVVAGVIGARKPQYDIWGNTVNVASRMDTTGMIGEIQVTEETANVLMELGFTCET 854
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSI 522
RG + VKGKG + TY + + SI
Sbjct: 855 RGIISVKGKGKLKTYIVRRMSRSI 878
Score = 51.2 bits (117), Expect = 1e-04
Identities = 21/54 (38%), Positives = 34/54 (62%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ GV+G RK QYD+W + V +A+ M+S G+ + +TQ D L +
Sbjct: 193 GVHTGNVLCGVLGLRKWQYDVWSHDVTLANHMESCGVPGRVHITQATLDNLGLK 246
>UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1285
Score = 172 bits (419), Expect = 2e-41
Identities = 126/421 (29%), Positives = 201/421 (47%), Gaps = 36/421 (8%)
Query: 16 YTAERDRMLKVYFSCSLVVYTAVLIVQLLAF--NMTPIGI--ATMILCGIIVVSVTYLIF 71
Y + D + C+ +++ ++ ++Q++ F N+ IG AT + G+ + +
Sbjct: 795 YRTQPDSSFRYDLICTFILFLSIGLIQIVVFKSNVVVIGSLSATTVALGLFLYLSNRQMS 854
Query: 72 AIDLKFAGG--------KLKRISKRVHNNRTLAQLMSFIVVG-AVILQIQVVMVQEVLGV 122
+ + G + RI+ V + +A F VV +L+++V +Q V
Sbjct: 855 DLSSPASNGPGQVIAANRSLRIAIFVISTALIAACAIFSVVSIGGVLKLRVRQLQSKPMV 914
Query: 123 TNNTNVPSYENSGGNCPYDMNEHYLQVTLMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXX 182
+ NV N + YD+ + + + +++CA+
Sbjct: 915 KVSANVLLVNNGTESVTYDVQ--FAPLAPVYLYMCAISLAAVSAFLQSGFIIKLLLMLLF 972
Query: 183 XX-QEHLYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTY--RLDFIW 239
Q L +++ ++ W + L +A +LH+ + Y R DF+W
Sbjct: 973 IGVQCSLLWQSSLFETYQILNNSWPLAFQGGLFLL--LIASVLHTLDRQGEYVSRTDFLW 1030
Query: 240 KLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVM 299
K + E+E++E ++ N+ LL NILP HVAQHFL ++ + QELYHE SV VM
Sbjct: 1031 KAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAV-----QELYHESYSSVAVM 1085
Query: 300 FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAAS 359
FASIPN+ EFY E + N +G+ECLRLLNEII DFD++L + F IEKIK+ G+TYM AS
Sbjct: 1086 FASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMVAS 1145
Query: 360 GL----------TNSTQDLVGYRH-VTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCS 408
GL N + H V + D+A+ L L +N SF FR+RIG +
Sbjct: 1146 GLRPGKEEGATKNNELDEKRTEEHNVVVLVDFAIALMTALDQINRESFQRFRLRIGLNHG 1205
Query: 409 P 409
P
Sbjct: 1206 P 1206
Score = 108 bits (260), Expect = 5e-22
Identities = 47/82 (57%), Positives = 61/82 (74%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPV+AGVIGA+KPQYDIW N VNVASRMDS G++ IQV++ +L A GY
Sbjct: 1197 RLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRIQVSENTAKVLMAAGY 1256
Query: 495 KLRCRGTVDVKGKGNMVTYFLE 516
CRG + VKGKG + TY+++
Sbjct: 1257 SCECRGPIPVKGKGILTTYYVK 1278
Score = 50.4 bits (115), Expect = 2e-04
Identities = 21/54 (38%), Positives = 34/54 (62%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
GI+ G V+ GV+G RK Q+D+W + V +A+ M+S G+ + +T+ D L R
Sbjct: 375 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKATLDYLGDR 428
>UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF8089, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 821
Score = 171 bits (417), Expect = 4e-41
Identities = 90/196 (45%), Positives = 127/196 (64%), Gaps = 11/196 (5%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
V L+ ++Q E R+DF+ E+E+ME ++ NR LL N+LP VA FL K
Sbjct: 554 VVCLILARQDELGCRVDFLLDRCFQMEREEMETMENINRLLLQNVLPFDVASFFL--GKT 611
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
I Q+LY + D VCVMFAS+P F EFY E NN+G+ECLR LNEII+DFDE+L++
Sbjct: 612 IRN---QDLYSQSYDCVCVMFASVPQFKEFYSESSANNDGLECLRFLNEIISDFDELLSK 668
Query: 340 EPFKYIEKIKSTGATYMAASGLT------NSTQDLVGYRHVTAMADYALRLREQLQYVNE 393
F +EKIK+ G+TYMAA+GLT + + + Y HV AM ++A+ L +L+++N+
Sbjct: 669 PKFSSVEKIKTIGSTYMAAAGLTLAPVGDENKKVEMSYSHVRAMVEFAIALMSKLEFINK 728
Query: 394 HSFNCFRIRIGKSCSP 409
HSFN F++RIG + P
Sbjct: 729 HSFNIFKLRIGINHGP 744
Score = 115 bits (277), Expect = 4e-24
Identities = 51/77 (66%), Positives = 64/77 (83%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPV+AGVIGA KPQYDIWGN+VNVASRM+STG+LD IQVT+E ++ + GY +
Sbjct: 739 GINHGPVIAGVIGAHKPQYDIWGNSVNVASRMESTGVLDKIQVTEETSQMVESVGYNVTL 798
Query: 499 RGTVDVKGKGNMVTYFL 515
RG V+VKGKG++ TYF+
Sbjct: 799 RGVVNVKGKGDLTTYFV 815
Score = 56.4 bits (130), Expect = 3e-06
Identities = 54/203 (26%), Positives = 92/203 (45%), Gaps = 18/203 (8%)
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LY Q V +++A I F++ L E + +LN++ FD+I + +
Sbjct: 45 LYIRQHKDVSILYADIVGFTKLASSLSPQ----ELVAVLNKLFGRFDDIAKKNGCL---R 97
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
IK G Y SGL + + H L + ++ V+ + + S
Sbjct: 98 IKILGDCYYCVSGLPDPIPN-----HARNCVQMGLDMCTAIRCVSFMVLSSLGLLFLLSW 152
Query: 408 SPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVA 467
S ++ C+ ++R E G I RV G++ G V+ GVIG +K QYD+W + V +A
Sbjct: 153 SRNNDFP--CGCS-KLR-EATGVEISMRV--GVHTGNVLCGVIGLQKWQYDVWSHDVTLA 206
Query: 468 SRMDSTGLLDHIQVTQEVYDILS 490
+ M+S GL + +T+E L+
Sbjct: 207 NHMESGGLPGRVHITEETLQHLN 229
>UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate
cyclase 7; n=1; Equus caballus|Rep: PREDICTED: similar
to adenylate cyclase 7 - Equus caballus
Length = 958
Score = 171 bits (416), Expect = 6e-41
Identities = 84/181 (46%), Positives = 119/181 (65%), Gaps = 11/181 (6%)
Query: 234 RLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQC 293
RLD +WK + +E E+ E ++ NR LL N+LP HVA HF+ N ++ YH+
Sbjct: 700 RLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLN------EDWYHQSY 753
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
D VCVMFAS+P+F FY E + N EG+ECLRLLNEI+ADFDE+L + F +EKIK+ G+
Sbjct: 754 DCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIVADFDELLLKPKFSGVEKIKTIGS 813
Query: 354 TYMAASGLT----NSTQDLV-GYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCS 408
TYMAA+GL+ + QDL + H+ M ++++ L +L +N HSFN FR+R+G +
Sbjct: 814 TYMAAAGLSVPSGHDNQDLERQHAHIGIMVEFSIALMSKLDGINRHSFNSFRLRVGINHG 873
Query: 409 P 409
P
Sbjct: 874 P 874
Score = 117 bits (281), Expect = 1e-24
Identities = 54/81 (66%), Positives = 62/81 (76%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GIN GPV+AGVIGARKPQYDIWGN VNVASRM+STG L IQVT+E IL GY
Sbjct: 865 RLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETSAILQGLGY 924
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
CRG ++VKGKG + TYF+
Sbjct: 925 SCECRGLINVKGKGELRTYFV 945
Score = 50.4 bits (115), Expect = 2e-04
Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
E G I RV GI+ G V+ GVIG RK QYD+W + V++A+RM++ G+ + +T+
Sbjct: 235 EATGVDISMRV--GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITE 290
>UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to
ENSANGP00000010056; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010056 - Nasonia
vitripennis
Length = 947
Score = 166 bits (404), Expect = 2e-39
Identities = 121/405 (29%), Positives = 199/405 (49%), Gaps = 27/405 (6%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYLIFAID 74
QY +RD Y S ++Y + VQ + + I I G++ +S+ I +
Sbjct: 478 QYREQRDEQYPWYVLVSTLLYLIMFFVQTV-YMPGNITIYGCFGAGLLCLSMLSAISWLA 536
Query: 75 LKFAGGKLKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVPSYENS 134
+ G+ S + ++ ++ + + G ++I V ++ VL V ++V S +
Sbjct: 537 SRNGKGRSSNDS-HIVSSSSIGEERVLLSRG---IRISVYLITAVLAVA--SSVVSLVDV 590
Query: 135 GGNCPYDMNEHYLQVTLMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXXQEHLYYRNHF 194
N M Y++ +A+ + H + + ++++
Sbjct: 591 NPNWEKSMAPMYVECAAIALIVAWTH-LRVGSLLKLSVMIISILTLLGIFSQCQVIQDYY 649
Query: 195 YDYQHRCGLDWNQQWTNIAIALGATVALLLH--SQQTESTYRLDFIWKLQANEEKEDMEH 252
YD ++ I L A V L+LH ++ E T R DF+WK + E++++E
Sbjct: 650 YDPRNE--FFKVHYLVQIGFLL-ALVGLVLHVLDRRIEYTSRTDFLWKNKLKVEQDEVET 706
Query: 253 LQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVE 312
++ N+ LL NILP HVA HFL + +N Q+LYHE +S+ VMFASIPN+ EFY E
Sbjct: 707 MRGINKILLENILPAHVAGHFLATREN------QDLYHESYNSIAVMFASIPNYKEFYDE 760
Query: 313 LEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGY- 371
+ N +G+ECLRLLNEII DFD++L + + IEKIK+ G+TYM A GL+ +D G
Sbjct: 761 TDINKQGLECLRLLNEIICDFDKLLLKPKYSSIEKIKTIGSTYMLACGLSPGKEDGDGLI 820
Query: 372 -------RHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
+V + ++A+ L L +N SF F++RIG + P
Sbjct: 821 DLTKQREHNVIVLVEFAISLTTLLDQINRESFQRFKLRIGLNHGP 865
Score = 110 bits (265), Expect = 1e-22
Identities = 51/87 (58%), Positives = 64/87 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N GPV+AGV+GA+KPQYDIWGN VNVASRMDS G + IQVT++ IL GY+L C
Sbjct: 860 GLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKIQVTEDTAKILRNAGYELIC 919
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDD 525
RG VKGKG + TYF++ D+ D+
Sbjct: 920 RGPTYVKGKGTLTTYFVKTPFDNKEDN 946
Score = 46.8 bits (106), Expect = 0.002
Identities = 20/45 (44%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
GI+ G V+ GV+G RK Q+D+W + V +A+ M+S GL + VT+
Sbjct: 294 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGKVHVTK 338
Score = 41.5 bits (93), Expect = 0.078
Identities = 45/206 (21%), Positives = 88/206 (42%), Gaps = 23/206 (11%)
Query: 210 TNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHV 269
+++ L A +A L + T +R F E + +E + +LL +++P ++
Sbjct: 101 SDVFFVLTALIAGLYYRVLTSRAHRQTFASTKTIIESRIKLECEREQQEQLLLSVIPAYI 160
Query: 270 AQHF----------LCSD-KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
A C + Q E+Y ++ ++V +++A I NF+ +L +
Sbjct: 161 AAEVKRSIMLKMADACQEVSKHKQTRFHEMYVQRHNNVSILYADIVNFTPLSEQLSAS-- 218
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
+ ++ LNE+ FD+I + +IK G Y SGL S + H
Sbjct: 219 --DLVKTLNELFGRFDQIAQD---NQCMRIKILGDCYYCVSGLPVSRPN-----HAYNCV 268
Query: 379 DYALRLREQLQYVNEHSFNCFRIRIG 404
+ L++ E +++V E + +RIG
Sbjct: 269 NMGLQMIEAIRFVREATGFNVDMRIG 294
>UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl
cyclase 76E CG7978-PA; n=1; Apis mellifera|Rep:
PREDICTED: similar to Adenylyl cyclase 76E CG7978-PA -
Apis mellifera
Length = 969
Score = 165 bits (402), Expect = 3e-39
Identities = 90/198 (45%), Positives = 128/198 (64%), Gaps = 13/198 (6%)
Query: 220 VALLLH--SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD 277
V L+LH +Q E T R DF+W+ + E++++E ++ N+ LL NILP HVA+HFL +
Sbjct: 695 VCLVLHVLDRQIEYTSRTDFLWESKLKIEQDEVETMRGINKILLENILPAHVAEHFLTNV 754
Query: 278 KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEIL 337
+ I Q+LYHE+ S+ VMFASIPN+ EFY E + N +G+ECLRLLNEII DFD++L
Sbjct: 755 RAI-----QDLYHERYSSIAVMFASIPNYKEFYDETDINKQGLECLRLLNEIICDFDKLL 809
Query: 338 AEEPFKYIEKIKSTGATYMAASGL-----TNSTQDLVGYRH-VTAMADYALRLREQLQYV 391
+ F IEKIK+ G+TYM ASGL T+ + L H + + ++AL L L +
Sbjct: 810 LKPKFSGIEKIKTIGSTYMLASGLSPGKDTDEKELLKQENHNIIILIEFALALMTILDQI 869
Query: 392 NEHSFNCFRIRIGKSCSP 409
N+ SF F++RIG + P
Sbjct: 870 NKESFQKFKLRIGLNHGP 887
Score = 112 bits (269), Expect = 4e-23
Identities = 49/78 (62%), Positives = 62/78 (79%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N GPV+AGV+GA+KPQYDIWGN VNVASRMDS G + +QVT++ IL A GY+L C
Sbjct: 882 GLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKVQVTEDTAKILIAAGYELIC 941
Query: 499 RGTVDVKGKGNMVTYFLE 516
RG VKGKG ++TYF++
Sbjct: 942 RGPTYVKGKGTLITYFVK 959
Score = 46.8 bits (106), Expect = 0.002
Identities = 19/45 (42%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
GI+ G V+ GV+G RK Q+D+W + V +A+ M+S GL + +T+
Sbjct: 366 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGRVHITK 410
Score = 37.9 bits (84), Expect = 0.96
Identities = 50/229 (21%), Positives = 93/229 (40%), Gaps = 25/229 (10%)
Query: 187 HLYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEE 246
HL R F D H Q + I A ++ +S T + F E
Sbjct: 152 HLSIRFIFLD--HSSYYQIVQTCSEIIFLFTAILSGSYYSILTAKAHNRTFARTKTVIES 209
Query: 247 KEDMEHLQAYNRKLLANILPEHVAQHF----------LCSD-KNIDQFDAQELYHEQCDS 295
+ +E + +LL +++P ++A C + N Q E+Y ++ ++
Sbjct: 210 RIKLECEREQQEQLLLSVIPAYIAAEVKRGIMLKMANACQEVSNHKQTRFYEMYVQRHNN 269
Query: 296 VCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATY 355
V +++A I NF+ +L ++ +++LNE+ FD+I + +IK G Y
Sbjct: 270 VSILYADIVNFTPLSEQLSASS----LVKILNELFGRFDQIAQD---NQCMRIKILGDCY 322
Query: 356 MAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
SGL S + H L++ + +++V E + +RIG
Sbjct: 323 YCVSGLPISRPN-----HAYNCVTMGLQMIDAIKFVREATGFNVDMRIG 366
>UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29;
Euteleostomi|Rep: Adenylate cyclase type 9 - Homo sapiens
(Human)
Length = 1353
Score = 165 bits (400), Expect = 5e-39
Identities = 115/289 (39%), Positives = 156/289 (53%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D + ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNNNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 44.8 bits (101), Expect = 0.008
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate
cyclase 8; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to adenylate cyclase 8 - Tribolium castaneum
Length = 912
Score = 164 bits (399), Expect = 7e-39
Identities = 128/400 (32%), Positives = 198/400 (49%), Gaps = 36/400 (9%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILC-GIIVVSVTYLIFAI 73
QYT ++ M + C +++ LI QL+ F+ T +AT+ + + + VT L+
Sbjct: 425 QYTEIKNDMYRSNIVCCFIMWIFALICQLIVFDPTQPTLATLFISVSVFLALVTLLVAGD 484
Query: 74 DLKFAGGKLKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVPSYEN 133
K +K+ +K + +NR AV+ + ++M + GV+ +N
Sbjct: 485 QYKHFPKIVKKFNKSLSSNRRRRT--------AVLASVVIIM--SMSGVSTLIIESKLKN 534
Query: 134 SGGNCPYDMNEHYLQVTLM-AMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXXQEHLYYRN 192
+ N H +V ++L A+ YR
Sbjct: 535 DANS-----NIHPEKVIFSWIIYLFALATAIRINYRIKILLAFLLVSVYVILANIEPYRQ 589
Query: 193 HFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEH 252
HF+ L Q+ + +A + + H++ E T RL F+WK +A E + M
Sbjct: 590 HFFPEIENSLLPI--QFPVLLVAF--FLLIFYHARLIEVTSRLYFLWKHKAQIELDGMRA 645
Query: 253 LQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVE 312
+ N +LL N+LPEHVA+HFL + + +ELY + D + V+FA+IPNFS+FY E
Sbjct: 646 ARQTNMQLLTNVLPEHVAKHFLSRE-----YRNEELYSQARDGIGVLFATIPNFSKFYSE 700
Query: 313 LEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIK--STGATYMAASGLTNSTQ--DL 368
+G +ECLRLLNEIIA FDE+L +E F IEKIK S ATYMA SGL S + L
Sbjct: 701 AKG----LECLRLLNEIIATFDEVLDDERFSSIEKIKTVSATATYMAVSGLNPSIKHDPL 756
Query: 369 VG--YRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKS 406
+G H+ A+ D+A+ LR++L+ +N SFN F +R+G S
Sbjct: 757 IGDTPEHLGALIDFAITLRQRLEEINRDSFNRFNLRVGIS 796
Score = 96.7 bits (230), Expect = 2e-18
Identities = 51/100 (51%), Positives = 66/100 (66%), Gaps = 2/100 (2%)
Query: 420 TLRVRVEPGGALIVRR--VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLD 477
TLR R+E R + GI+ G +V GVIGA+KP +D+WGN VN ASRMDSTGL+
Sbjct: 773 TLRQRLEEINRDSFNRFNLRVGISYGDLVCGVIGAKKPIFDVWGNTVNEASRMDSTGLMG 832
Query: 478 HIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
IQV + +L +GY+L+ RG V VKGKG M T+F+ G
Sbjct: 833 EIQVPKNTAQLLVHQGYELKKRGLVRVKGKGLMETFFVLG 872
Score = 52.0 bits (119), Expect = 6e-05
Identities = 34/119 (28%), Positives = 61/119 (51%), Gaps = 12/119 (10%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA--RGYKL 496
GI+ G V+ GV+G RK Q+DIW + V +A+RM++TG+ + ++ L+ R
Sbjct: 239 GIHSGSVLCGVLGLRKWQFDIWSHDVKIANRMEATGIAGRVHISDATLRALTKEFRVEAA 298
Query: 497 RCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNN-PIPSTSSEGAVPPRPEHRPLDTLSE 554
R + K ++ TYF+ + D +Y N +P ++ PP+ + +D + E
Sbjct: 299 HGREKDSLLRKNDIQTYFI------LEDPVYENVELPKMATP---PPKRQSVNVDWIPE 348
Score = 44.0 bits (99), Expect = 0.015
Identities = 35/145 (24%), Positives = 67/145 (46%), Gaps = 13/145 (8%)
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA--- 285
T+ + R F+ L+ E + + +L+ +ILP+ VA+ +N ++ +
Sbjct: 70 TDGSQRRSFVQTLRFLENRFKAQQENEKQVQLIFSILPDFVAKEMFADIENEERRGSVQP 129
Query: 286 ---QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPF 342
++Y + ++V ++FA I F+ L E +R LN++ A FD++ +
Sbjct: 130 QQFHKIYIHKYNNVSILFADIKGFTA----LASKCTAQELVRNLNDLFARFDKLATKHDC 185
Query: 343 KYIEKIKSTGATYMAASGLTNSTQD 367
+IK G Y SGL N+ +D
Sbjct: 186 L---RIKLLGDCYYCVSGLPNARED 207
>UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whole
genome shotgun sequence; n=3; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14199,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 982
Score = 161 bits (392), Expect = 5e-38
Identities = 90/207 (43%), Positives = 133/207 (64%), Gaps = 19/207 (9%)
Query: 209 WTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEH 268
W AI + T+A++ + +S R F+WK+ +++KE + ++ N L+ N+LPEH
Sbjct: 683 WAMAAIFV-LTMAVIADMLEVQS--RKLFLWKIGVHDQKEKVFEMRRCNEALVTNMLPEH 739
Query: 269 VAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNE 328
VA+HFL + K +ELY + + VMFASIPNFS+FY E NN G+ECLR+LNE
Sbjct: 740 VAKHFLGTKKR-----DEELYSQSYSQIGVMFASIPNFSDFYTEEGINNGGIECLRILNE 794
Query: 329 IIADFDEILAEEPFKYIEKIKSTGATYMAASGLT--------NSTQD---LVGYRHVTAM 377
II+DFD +L +E F+ I KIK+ G+TYMAASGLT N ++D + +RH++ +
Sbjct: 795 IISDFDSLLDKEEFRSITKIKTIGSTYMAASGLTPECHTNGYNKSEDQPLVEHWRHLSDL 854
Query: 378 ADYALRLREQLQYVNEHSFNCFRIRIG 404
AD+AL ++ L +N+ SFN F +RIG
Sbjct: 855 ADFALSMKVTLNNLNKQSFNNFMLRIG 881
Score = 107 bits (257), Expect = 1e-21
Identities = 48/79 (60%), Positives = 62/79 (78%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV ++ YDIL G+
Sbjct: 881 GINKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYDILKEYGFHFVR 940
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+F++G
Sbjct: 941 RGPIFVKGKGELLTFFMKG 959
Score = 60.5 bits (140), Expect = 2e-07
Identities = 53/204 (25%), Positives = 93/204 (45%), Gaps = 19/204 (9%)
Query: 207 QQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILP 266
Q ++ + L A + ++ + YR+ F+ ++ E K +E +LL +ILP
Sbjct: 223 QLLASVMLYLCAAMVGVMSYYMADRKYRMAFLEARRSLEVKLTLEEQSTQQEELLLSILP 282
Query: 267 EHVAQHFLCSDKN-IDQFDAQE----LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
+H+A L KN Q + Q+ +Y + ++V ++FA I F+ +L E
Sbjct: 283 KHIADEMLQGMKNQAQQQEVQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQE 338
Query: 322 CLRLLNEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADY 380
++LLNE+ A FD++ A KY + +IK G Y GL + D H
Sbjct: 339 LVKLLNELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDFRDD-----HAACSIMM 389
Query: 381 ALRLREQLQYVNEHSFNCFRIRIG 404
L + + + YV E + +R+G
Sbjct: 390 GLAMVDAISYVREKTRTEVDMRVG 413
Score = 46.0 bits (104), Expect = 0.004
Identities = 17/51 (33%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ Q+D+W V +A++M+S G+ + ++Q D L
Sbjct: 413 GVHTGTVLGGVLGQKRWQFDVWSTDVTLANKMESGGIPGRVHISQTTKDSL 463
>UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1400
Score = 161 bits (391), Expect = 6e-38
Identities = 90/188 (47%), Positives = 123/188 (65%), Gaps = 11/188 (5%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFD 284
H++ E T RLDFIWK QA +E +M+ + N L+ NILP+HVA ++L S++ D+
Sbjct: 1005 HARLVEVTSRLDFIWKEQAEKELSNMKSNRHLNDLLIKNILPDHVASYYL-SEERADELY 1063
Query: 285 AQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
AQ HE C VMFASIPNF +FY E N G C+R+LNEII+DFD +L EE FK
Sbjct: 1064 AQ--MHELCG---VMFASIPNFKDFYSEDIEN--GKACIRILNEIISDFDSLLEEERFKT 1116
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD---YALRLREQLQYVNEHSFNCFRI 401
+EKIK+ GATYMAAS L + + V + A+ D +AL +R++LQ VN+ +FN F++
Sbjct: 1117 VEKIKTVGATYMAASNLRSGNKTKVDEKDEEAVCDLVEFALAMRQKLQEVNKDAFNTFQL 1176
Query: 402 RIGKSCSP 409
R+G S P
Sbjct: 1177 RVGISSGP 1184
Score = 96.7 bits (230), Expect = 2e-18
Identities = 48/83 (57%), Positives = 59/83 (71%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GP+V+GVIGARKP YDIWGN VNVASRMDSTG +QV +L +GY
Sbjct: 1179 GISSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWKVQVPDYTAALLQTKGYTCVQ 1238
Query: 499 RGTVDVKGKGNMVTYFLEGVGDS 521
RG V+VKGKG M+TY++ G+ S
Sbjct: 1239 RGEVNVKGKGLMLTYWVLGMNVS 1261
Score = 46.8 bits (106), Expect = 0.002
Identities = 45/158 (28%), Positives = 69/158 (43%), Gaps = 12/158 (7%)
Query: 207 QQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILP 266
Q N + L A + T+ RL FI +A E K + E ++LL +ILP
Sbjct: 274 QMIANSLLYLAINFAGMYTKYLTDRGQRLAFIETHKAMEHKRESEKEYQRTQRLLDSILP 333
Query: 267 EHVAQHF---LCSDKNIDQFDAQ--ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
V + Q D Q +LY D+V ++FA I F+ EL +
Sbjct: 334 MFVNNDIRKEMYKSPEQPQVDTQFKKLYIYHMDNVSILFADIKGFT----ELASKTSAQQ 389
Query: 322 CLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAAS 359
+++LN++ A FD+I AE+ + +IK G Y S
Sbjct: 390 LVKVLNDLFARFDKI-AED--NHCLRIKLLGDCYYCVS 424
Score = 44.0 bits (99), Expect = 0.015
Identities = 17/52 (32%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
GI+ G V+ GV+G +K +D+W N V +A+ M+S G+ + +++ + L+
Sbjct: 468 GIHSGSVMCGVLGEKKWHFDVWSNDVIIANHMESGGVPGRVHISEATLNCLN 519
>UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1246
Score = 160 bits (389), Expect = 1e-37
Identities = 122/413 (29%), Positives = 194/413 (46%), Gaps = 26/413 (6%)
Query: 16 YTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYLIFAIDL 75
YT + D M Y + V++ + I Q + + + T + ++ +VT + F +
Sbjct: 760 YTKQSDDMFPFYVMITFVIFVVIFITQAIMLPRSTMYFVTSTVGILLFTAVTIICFCNQI 819
Query: 76 KFA--GGK----LKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
F G K L+R+S + + ++S +G + L + + + G N+T
Sbjct: 820 PFLKRGHKYLRILQRMSTYIEQSYWTRIVLSLGCMGLISL-VSTLSLVHCEGPGNSTMSS 878
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXXXXXQEHL 188
NS P Y L+ L + I H+
Sbjct: 879 HLANSTTLTPGTSACSYPSYYLVCFLLAFTGYSIFVQISFIIKFIFYCLMFVVVNIVVHV 938
Query: 189 YYRNHF--YDYQHRCGLDW-NQQWTNIAIALGATVALLL---H--SQQTESTYRLDFIWK 240
+ F YD + D N + VA+LL H +Q E RL ++K
Sbjct: 939 GRGDMFDLYDQNLKSSNDGLNTFMVPLKAKTSVYVAMLLITMHFLDRQMEYANRLGHLFK 998
Query: 241 LQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMF 300
+Q E E ++ + A N+ +L NI+P HV ++L S + ++LYHE +SV VMF
Sbjct: 999 MQFQRETEQVKMMAAINKIVLENIIPSHVIAYYLRSSRK-----HEDLYHEAYESVSVMF 1053
Query: 301 ASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASG 360
ASIPNF +FY + + N EG+EC+R+LNEII+DFD +L + F+ +EKIK+ G+TYMAA+G
Sbjct: 1054 ASIPNFKDFYQQTKSNGEGMECIRVLNEIISDFD-LLVIKKFQDVEKIKTIGSTYMAATG 1112
Query: 361 L----TNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
L + D G R + M +++L + L VN+HSFN F +RIG + P
Sbjct: 1113 LHRGQAGNQDDEAGERTIVTMVEFSLAMMSTLDTVNQHSFNNFSLRIGVNHGP 1165
Score = 97.1 bits (231), Expect = 1e-18
Identities = 46/77 (59%), Positives = 55/77 (71%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N GPV+AGVIGARKPQYDIWG+ VNVASRMDS+G IQ+ +E +L GY L
Sbjct: 1160 GVNHGPVIAGVIGARKPQYDIWGDTVNVASRMDSSGEPGKIQMREETAAVLVKYGYNLEL 1219
Query: 499 RGTVDVKGKGNMVTYFL 515
RG VKGK M T++L
Sbjct: 1220 RGITKVKGKEPMKTFYL 1236
Score = 50.4 bits (115), Expect = 2e-04
Identities = 19/51 (37%), Positives = 34/51 (66%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G RK QYD+W + V +A+ M+S G+ + ++++ D L
Sbjct: 553 GVHTGSVLCGVLGLRKWQYDVWSDDVTIANNMESGGVPGRVHISKQTLDCL 603
Score = 38.3 bits (85), Expect = 0.73
Identities = 40/202 (19%), Positives = 86/202 (42%), Gaps = 16/202 (7%)
Query: 207 QQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILP 266
Q + N + A + L H ++ +R F+ + + +E + +LL + +P
Sbjct: 364 QLFCNFLVLSSANIIGLTHKFLSDVAHRRAFLDARNSVDSMIKLEKEKQQQDELLVSCIP 423
Query: 267 EHVAQHFLCS-DKNIDQFDA---QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
++ + +N+ + +LY ++ V +++A I NF+ E E
Sbjct: 424 SNLVKEIKKDLQENMREPRPTLFHDLYVQRYHGVSILYADIVNFTPLASECTA----AEL 479
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+++LNE+ FD++ + +IK G Y SG+ + + +H L
Sbjct: 480 VKMLNELFGRFDQLAKKSS---CMRIKILGDCYYCVSGIPTADK-----KHAHNCVRMGL 531
Query: 383 RLREQLQYVNEHSFNCFRIRIG 404
R+ + ++ V E++ +RIG
Sbjct: 532 RMLDAIRDVRENTGVDVDMRIG 553
>UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2;
Sophophora|Rep: Adenylate cyclase type 2 - Drosophila
melanogaster (Fruit fly)
Length = 1307
Score = 160 bits (388), Expect = 1e-37
Identities = 86/198 (43%), Positives = 119/198 (60%), Gaps = 14/198 (7%)
Query: 220 VALLLHSQQTESTY--RLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD 277
+ L+LH+ + Y R DF+WK + E+E++E ++ N+ LL NILP HVA HFL +
Sbjct: 1037 IILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE 1096
Query: 278 KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEIL 337
++ ELYHE V VMFASIPN+ EFY E + N +G+ECLRLLNEII DFD++L
Sbjct: 1097 RST------ELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLL 1150
Query: 338 AEEPFKYIEKIKSTGATYMAASGLTNSTQD------LVGYRHVTAMADYALRLREQLQYV 391
+ F IEKIK+ +TYM ASGL +D +V + ++A+ L L +
Sbjct: 1151 LKPKFSGIEKIKTIASTYMCASGLRPGKEDGATDEKRTEEHNVVILVEFAIALMSILDSI 1210
Query: 392 NEHSFNCFRIRIGKSCSP 409
N SF FR+RIG + P
Sbjct: 1211 NRESFQRFRLRIGLNHGP 1228
Score = 111 bits (267), Expect = 6e-23
Identities = 49/82 (59%), Positives = 61/82 (74%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPV+AGVIGA+KPQYDIW N VNVASRMDS G++ +Q T+ IL GY
Sbjct: 1219 RLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGY 1278
Query: 495 KLRCRGTVDVKGKGNMVTYFLE 516
+ CRG VKGKGN+VTYF++
Sbjct: 1279 ECECRGLTYVKGKGNLVTYFVK 1300
Score = 50.8 bits (116), Expect = 1e-04
Identities = 20/51 (39%), Positives = 34/51 (66%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GI+ G V+ GV+G RK Q+D+W + V +A+ M+S G+ + +T++ D L
Sbjct: 412 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFL 462
Score = 37.1 bits (82), Expect = 1.7
Identities = 31/118 (26%), Positives = 56/118 (47%), Gaps = 12/118 (10%)
Query: 287 ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIE 346
EL+ ++ +V ++FA I NF+ L + + ++ LN++ FD+I E
Sbjct: 307 ELHVQRHTNVTILFADIVNFTPLSSSLTAS----DLVKTLNDLFGRFDQIAQE---NQCL 359
Query: 347 KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+IK G Y SGL S +H T + L++ + +++V E + +RIG
Sbjct: 360 RIKILGDCYYCVSGLPISRP-----QHATNCVNMGLQMIDAIRHVREATGINVDMRIG 412
>UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1154
Score = 159 bits (386), Expect = 2e-37
Identities = 116/339 (34%), Positives = 174/339 (51%), Gaps = 23/339 (6%)
Query: 192 NHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDME 251
++ YD N + ++ + + + +Q+E R+D+ WK Q ++KE+ E
Sbjct: 803 HYIYDNSASMNPGMNSKVAHLLLVVFTVIVFQWIDRQSEYIARVDYNWKRQLLKQKEEAE 862
Query: 252 HLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYV 311
+ N+ L+ NILP HVA+ + I++ E Y+E+ +V VMFA+I N +
Sbjct: 863 VTKQTNKILVENILPTHVAEIY------INRQLKNEFYNEEYKNVAVMFATITNM-DINT 915
Query: 312 ELEGNNEGVECLRLLNEIIADFDEILAE-EPFKYIEKIKSTGATYMAASGLT----NSTQ 366
++ NE L++LNEII DFDE L + + +EKIK G TYMAA GL +S+
Sbjct: 916 DISVENEK-SVLKVLNEIICDFDEKLQYFDGYLKVEKIKVAGWTYMAACGLDPGRCDSSS 974
Query: 367 DLVGYRHVTAMADYALRL--REQLQYVNEHSFNCFRIRIGKSCSPSD-ATASSANCTLRV 423
L YR V+ + +L R L R S S+ T L +
Sbjct: 975 SLGPYRSVSGITRTSLMTNGRRSLNPRTSDLSPQLPHRNNSSTRHSNNVTIVMTEFALEL 1034
Query: 424 R-------VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLL 476
+E + GI+ G V+AGV+G+ KP YDIWGNAVN+ASRMDSTG+
Sbjct: 1035 MKVLRDFSIENFKQTNPGLLRVGISNGKVMAGVVGSSKPLYDIWGNAVNMASRMDSTGIP 1094
Query: 477 DHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
IQVT+E +I+ + GY+ RG + VKG+G + TYF+
Sbjct: 1095 GKIQVTKESAEIIQSYGYQCEYRGQIFVKGRGKIPTYFV 1133
Score = 53.2 bits (122), Expect = 2e-05
Identities = 23/51 (45%), Positives = 35/51 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GI+ G +++GVIGA K QYDIW V +A++M+STG + VT + ++L
Sbjct: 428 GIHSGSIISGVIGACKWQYDIWSRDVIIANKMESTGEAGKVHVTMQTLELL 478
>UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|Rep:
Adenylate cyclase type 3 - Homo sapiens (Human)
Length = 1144
Score = 159 bits (386), Expect = 2e-37
Identities = 127/427 (29%), Positives = 199/427 (46%), Gaps = 43/427 (10%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAI 73
+Y+ E+++ FSCS VV +V++L T ++ I+++ +T + AI
Sbjct: 623 RYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI 682
Query: 74 DLKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
+ KL S + R T A L FI+V A ++ + + +Q G +N T
Sbjct: 683 FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM 741
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXX----XXX 184
E S P N + + + L V H +
Sbjct: 742 ETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDE 801
Query: 185 QEHLYYRNH------FYDYQ-HRCGLDWNQQWTNIAIALGATVALLL-------HSQQTE 230
+H +R H Q GL+ + + TV + L S+ E
Sbjct: 802 YDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVE 861
Query: 231 STYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYH 290
R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K +ELY
Sbjct: 862 KLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----DEELYS 916
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
+ D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I KIK+
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 351 TGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
G+TYMAASG+T + ++H+ +AD+AL +++ L +N SFN
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 398 CFRIRIG 404
F +RIG
Sbjct: 1037 NFMLRIG 1043
Score = 102 bits (245), Expect = 3e-20
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 1103 RGPIFVKGKGELLTFFLKG 1121
Score = 61.3 bits (142), Expect = 9e-08
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 229 NVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 289 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 344
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 345 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 395
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 396 EAISYVREKTKTGVDMRVG 414
Score = 48.8 bits (111), Expect = 5e-04
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 464
>UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG5712-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to ACXD
CG5712-PA - Apis mellifera
Length = 1051
Score = 159 bits (385), Expect = 3e-37
Identities = 115/333 (34%), Positives = 173/333 (51%), Gaps = 39/333 (11%)
Query: 190 YRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKED 249
YR++ + R + +I + T +L L +Q E RLD++WK Q +E+++
Sbjct: 743 YRSNLFQSGDRWNPYLEPRLAHILSIVFLTFSLHLIDRQAEYLNRLDYLWKRQLTKEQDE 802
Query: 250 MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEF 309
H + N+ LL NILPEHVA+ +L ++ ++ E YHE +V VMFAS+ +
Sbjct: 803 AFHTRNANKFLLRNILPEHVAEFYLNMNRTVE----NEPYHEAHSNVAVMFASLTD---- 854
Query: 310 YVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD-L 368
V ++ +N L +LNEII +FD++L E F IEKIK G TYMAA GL S +D +
Sbjct: 855 -VSIDESN----TLAVLNEIICEFDKLLFEPYFNRIEKIKIAGTTYMAACGLEASRRDSM 909
Query: 369 VGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPG 428
+ + D +++ Q + ++R + P LR+ + G
Sbjct: 910 RSPENEENITDNVVKVMAQFAVEMIAVLDKLKMRTFYTSKP---------YRLRIGISHG 960
Query: 429 GALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
V AG V+GA+KP YDIWG+AVN+ASRMD+TG+ IQ+T E +
Sbjct: 961 ------EVTAG---------VVGAQKPLYDIWGDAVNMASRMDTTGVPGKIQITAETAAV 1005
Query: 489 LSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDS 521
L +G K RG VK KG + TYF+ G+ D+
Sbjct: 1006 LEQQGIKCHLRGDTYVKPKGLVTTYFI-GIDDN 1037
Score = 54.0 bits (124), Expect = 1e-05
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 3/73 (4%)
Query: 422 RVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
+VR E G + +R G++ G +++G++G K QYD+W V +A++M+ TG + +
Sbjct: 318 KVRRESGVDVNMR---IGVHSGNIISGILGVSKWQYDVWSRDVVIANKMEQTGKPGKVHI 374
Query: 482 TQEVYDILSARGY 494
TQ+ D++ A Y
Sbjct: 375 TQQTLDLVDANEY 387
>UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6.1.1)
(Adenylate cyclase type III) (ATP pyrophosphate-lyase 3)
(Adenylyl cyclase 3) (AC-III) (AC3) (Adenylate cyclase,
olfactive type).; n=1; Takifugu rubripes|Rep: Adenylate
cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III)
(ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III)
(AC3) (Adenylate cyclase, olfactive type). - Takifugu
rubripes
Length = 1159
Score = 155 bits (376), Expect = 4e-36
Identities = 119/422 (28%), Positives = 207/422 (49%), Gaps = 37/422 (8%)
Query: 16 YTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAID 74
Y++E+++ F C ++V + +++ M + T+ + ++++ +T + AI
Sbjct: 643 YSSEKEKRSGAAFCCCMMVLFFITAMEVFLDPMLVVNYVTLAVGEVLLLILTVCSLAAIF 702
Query: 75 LKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVPS 130
+ KL S + R T A F++ AVI + + V + ++N T+ P+
Sbjct: 703 PRMFSKKLVAFSLWIDFTRWARNTWAMAAIFVLTMAVIADM-LSCVPPAIQISNGTSGPA 761
Query: 131 YENSGGNCPYDMNEHYLQVTLMAMFLCAVH-QIXXXXXXXXXXXXXXXXXXXXXXQEHLY 189
E+ G +HY + +M++ + Q+
Sbjct: 762 LESYGDRGCTRNPKHYSFMAVMSLIATTLLVQVSHLIKLALMVLVVTAEGAVNIYSWRDI 821
Query: 190 YRNHFYDY----QHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANE 245
Y YDY +R + ++ + I + ++ + + E R F+WK+ ++
Sbjct: 822 Y--DLYDYVQFGSYRTSVVPSKYLMTVMIIV-MMISFYIFGRHLEVQSRKLFLWKIGVHD 878
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCS---DKNIDQFDAQELYHEQCDSVCVMFAS 302
+KE + ++ N L+ N+LPEHVA+HFL + D+ I + YH+ + + VMFAS
Sbjct: 879 QKEKVFEMRRCNEALVTNMLPEHVAKHFLGTKMRDEVIFSVYVRLHYHQSYNEIGVMFAS 938
Query: 303 IPNFSEFYVELEGNNEGVECLRLLNEIIADFD---------EILAEEPFKYIEKIKSTGA 353
IPNFS+FY E NN G+ECLR+LNEII+DFD ++L E F+ I KIK+ G+
Sbjct: 939 IPNFSDFYTEESINNGGIECLRILNEIISDFDSVTFFCLFHQLLDREEFRSITKIKTIGS 998
Query: 354 TYMAASGLT--------NSTQD---LVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIR 402
TYMAASGLT + +D ++H++ +AD+AL ++ L +N+ SFN F +R
Sbjct: 999 TYMAASGLTPECHTNGYDKPEDQSLFERWQHLSDLADFALSMKVTLNNLNKQSFNNFMLR 1058
Query: 403 IG 404
IG
Sbjct: 1059 IG 1060
Score = 106 bits (254), Expect = 2e-21
Identities = 47/79 (59%), Positives = 63/79 (79%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV ++ Y+IL G++
Sbjct: 1060 GINKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYNILKDYGFRFIR 1119
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+F++G
Sbjct: 1120 RGPIFVKGKGELLTFFMKG 1138
Score = 46.8 bits (106), Expect = 0.002
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ Q+D+W V VA++M+S G+ + ++Q D L
Sbjct: 441 GVHTGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGKVHISQTTKDSL 491
>UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 554
Score = 153 bits (372), Expect = 1e-35
Identities = 78/187 (41%), Positives = 118/187 (63%), Gaps = 6/187 (3%)
Query: 228 QTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQE 287
Q + R+ F+WK + +++KE ++ N L+ N+LP HVA+HF+ + K +
Sbjct: 297 QIDKVDRVIFMWKTEVSDQKERASDMRRRNEALVYNVLPMHVAEHFMGNRKR----SHDD 352
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LY + V V+FAS+PNFS+FY E NN+G+ECLR LNE+I+DFD +L F+ + K
Sbjct: 353 LYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDVIK 412
Query: 348 IKSTGATYMAASGLTNSTQDLVGYR--HVTAMADYALRLREQLQYVNEHSFNCFRIRIGK 405
IK+ G+TYMAASGL S D + R H+ + ++AL L++ LQ +NE SFN F +++G
Sbjct: 413 IKTIGSTYMAASGLNPSRIDPISVRWAHLALLVEFALELKKALQGINEQSFNHFVLKMGV 472
Query: 406 SCSPSDA 412
+ P A
Sbjct: 473 NHGPITA 479
Score = 109 bits (261), Expect = 3e-22
Identities = 50/79 (63%), Positives = 58/79 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N GP+ AGVIGARKP YDIWGN VNVASRM+STG IQVT+E IL GY
Sbjct: 471 GVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCQILQTFGYTFEQ 530
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG ++TY+L+G
Sbjct: 531 RGLVAVKGKGQLMTYYLQG 549
>UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl
cyclase type IX; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to adenylyl cyclase type IX -
Strongylocentrotus purpuratus
Length = 1073
Score = 152 bits (369), Expect = 3e-35
Identities = 108/305 (35%), Positives = 161/305 (52%), Gaps = 45/305 (14%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
I + L + + + +++ E +RL++ QA + E M+ LQ KLL +I+P+ V +
Sbjct: 801 ILVILLLLILIFVLNREYEIGFRLNYYSNYQALVDHEKMKSLQEEAEKLLHHIVPQFVTE 860
Query: 272 HFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL-EGNNEGVECLRLLNEII 330
+ K + + D+V V+F SI NF++FY E EG G EC+R+L+E+I
Sbjct: 861 QLRTTSK----------FSQNHDNVAVIFCSIVNFNDFYEEAYEG---GKECIRVLHELI 907
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQY 390
+DFD +L + +K +EKIK+ G+TYMAA GL S + +T M D++ + QLQ
Sbjct: 908 SDFDNLLNDPKYKEVEKIKTIGSTYMAACGLRPSEKPNNVQTLITLM-DFSDEMMMQLQK 966
Query: 391 VNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVI 450
N+ + T + N LR+ G N G + +GVI
Sbjct: 967 FNDDVLS--------------MTIGAFNFILRI---------------GYNHGKLTSGVI 997
Query: 451 GARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNM 510
G K YDIWG+ VNVASRMDSTG+ H+QVT+ +L Y+ RG V V+GKG+M
Sbjct: 998 GTTKLLYDIWGDTVNVASRMDSTGMPGHVQVTEHSMTVLEPY-YEFEKRGEVKVRGKGDM 1056
Query: 511 VTYFL 515
TY L
Sbjct: 1057 TTYLL 1061
Score = 50.0 bits (114), Expect = 2e-04
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G V+ G++G R+ ++D+W N V +A++M+++G + V+ E L R Y L
Sbjct: 308 GIHTGTVLCGIVGNRRFKFDVWSNDVTIANKMEASGQPGKVHVSAESIKFLKER-YVLD- 365
Query: 499 RGTVDVKG-KGNMVTYFLEGVGDSI-PDDIYNNPIPSTSS-EGA 539
G D M TYF+ G S P Y+ + S +S +GA
Sbjct: 366 EGNADKHALLIGMKTYFIAGRNASASPATKYHGNMSSVASLDGA 409
>UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to adenylate cyclase - Nasonia vitripennis
Length = 1092
Score = 151 bits (365), Expect = 9e-35
Identities = 112/312 (35%), Positives = 164/312 (52%), Gaps = 40/312 (12%)
Query: 219 TVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDK 278
T +L L +Q E RLD+ WK Q +E+++ H + N+ LL NILPEHVA +L
Sbjct: 814 TFSLHLIDRQAEYLNRLDYQWKRQLTKEQDEAFHTRNANKLLLRNILPEHVADFYL---- 869
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
N+D+ D LYHE D+V VMFA++ + S ++ +N V+ N+II FD++L
Sbjct: 870 NMDRADEHTLYHEAHDNVAVMFATLTDLS-----IDESNILVD----FNQIICHFDKLLF 920
Query: 339 EEPFK-YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALR-LREQLQYVNEHSF 396
E + IEKIK G TYMAA GL S + T+ +D +R +Q+ E +
Sbjct: 921 ESNYVCRIEKIKLAGTTYMAACGLEVSRRHSTQSSSSTSESDVKYNVVRVMVQFAAEMMY 980
Query: 397 NCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQ 456
I++ ++ LR+ + G V AG+ +GA+KP
Sbjct: 981 VLESIKM----------QTTRPYKLRIGIAHG------EVTAGV---------VGAQKPL 1015
Query: 457 YDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLE 516
YDIWG+AVN+ASRMD+TG + IQVT E ++L G + RG VK KG + TYF+
Sbjct: 1016 YDIWGDAVNMASRMDTTGEVGKIQVTTETAEVLKDEGIRCHLRGDTWVKPKGYVTTYFVG 1075
Query: 517 GVGDSIPDDIYN 528
D ++IY+
Sbjct: 1076 LNEDKELENIYD 1087
Score = 56.8 bits (131), Expect = 2e-06
Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
KSC + +R RV+ + V + G++ G +++G++G K QYD+W V
Sbjct: 378 KSCVDLGLDMINIINAVRARVQRESGVDVN-MRIGVHSGKIISGILGTNKWQYDVWSRDV 436
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGY 494
+A++M+ TG + VTQ+ D+L Y
Sbjct: 437 IIANKMEQTGEAGKVHVTQQTLDLLDVNSY 466
>UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora|Rep:
Adenylyl cyclase 78C-L - Drosophila melanogaster (Fruit
fly)
Length = 1718
Score = 150 bits (364), Expect = 1e-34
Identities = 85/201 (42%), Positives = 123/201 (61%), Gaps = 11/201 (5%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+ + + V + H++ E T RLDFIWK QA E +M+ +A N L+ NILP+HVA
Sbjct: 1311 LILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVAT 1370
Query: 272 HFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 331
++L SD++ D ELY + + VMFASIPNF +FY E N G C+R+LNEII
Sbjct: 1371 YYL-SDEHTD-----ELYSKMHNLCGVMFASIPNFQDFYSEDIDN--GKACIRILNEIIC 1422
Query: 332 DFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYR---HVTAMADYALRLREQL 388
DFDE+L E F +EKIK+ GATYMAA+GL + L G V + ++A ++++L
Sbjct: 1423 DFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKL 1482
Query: 389 QYVNEHSFNCFRIRIGKSCSP 409
+ +N +FN F++R+G P
Sbjct: 1483 EEINGDAFNNFQLRVGICSGP 1503
Score = 96.7 bits (230), Expect = 2e-18
Identities = 47/83 (56%), Positives = 58/83 (69%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI GP+V+GVIGARKP YDIWGN VNVASRMDSTG +QV + ++L +RGY
Sbjct: 1498 GICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVK 1557
Query: 499 RGTVDVKGKGNMVTYFLEGVGDS 521
RG + VKGKG M T+++ G S
Sbjct: 1558 RGEIAVKGKGMMTTFYVHPKGIS 1580
Score = 50.8 bits (116), Expect = 1e-04
Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 16/204 (7%)
Query: 207 QQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILP 266
Q + N + VA + T+ RL FI +A E K++ E +KLL +ILP
Sbjct: 481 QIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILP 540
Query: 267 EHV-----AQHFLCSDKNID-QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
V ++ + +D ++ QF+ +LY D+V ++FA I F+ EL
Sbjct: 541 NIVNNQIRSEMYKGTDPTVETQFN--KLYVYPMDNVSILFADIKGFT----ELASKTSAQ 594
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADY 380
+ +++LN++ A FD I AE+ + ++K G Y S S H +
Sbjct: 595 QLVKILNDLFARFDRI-AED--NHCLRVKLLGDCYYCVSQF-ESDNWKTRPDHAVCSVET 650
Query: 381 ALRLREQLQYVNEHSFNCFRIRIG 404
L + + ++ V H+ +RIG
Sbjct: 651 GLHMIKAIKDVRLHTHVDLNMRIG 674
Score = 43.2 bits (97), Expect = 0.026
Identities = 17/52 (32%), Positives = 32/52 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
GI+ G V+ GV+G +K +D+W N V +A+ M+S G+ + +++ L+
Sbjct: 674 GIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLN 725
>UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2;
Apocrita|Rep: ORF for hypothetical protein - Apis
mellifera (Honeybee)
Length = 998
Score = 149 bits (361), Expect = 3e-34
Identities = 118/386 (30%), Positives = 190/386 (49%), Gaps = 22/386 (5%)
Query: 31 SLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYLIFAIDLKFAGGKLKRISKRVH 90
SL+ V++ + P G T G++V+ L A L G +K + R
Sbjct: 538 SLLGGPLVMVCSAPVWRFQPWGPFTWGGIGVVVLFAVVLAGATCL---GSSIKAMWLR-- 592
Query: 91 NNRTLAQLMSFIVVGAVILQI-QVVMVQEVLGVTNNTNVPSYENSGGNCPYDMNEHYLQV 149
R LA LM F + ++L + V+V+E + N+TNV CPY Y+ V
Sbjct: 593 --RALASLMVFSLGLFLLLDMFNCVVVEETIPSLNSTNV----TLSTKCPYPSYYSYIGV 646
Query: 150 -TLMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXXQEHLYYRNHFYDYQHRCGLDWNQQ 208
TL+A + L + +H + ++
Sbjct: 647 LTLVATSMPTYICYLGKAYLMYAIAGSQCFINIWLLGSRLDWEDHASSPLEPSAVP-SKF 705
Query: 209 WTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEH 268
++ + AT +L++ S+ E + R+ ++ + ++E ++ N L+ NILP H
Sbjct: 706 CLSVTLLTVAT-SLVIVSRYAEKSRRMLYLRGREVVAQRERAADMKRRNGALIYNILPPH 764
Query: 269 VAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNE 328
VA +FL ++ D +LY + V V+FAS+PNF++FY E NN+G+ECLR LNE
Sbjct: 765 VAAYFLSRARHHD-----DLYSQSYAEVGVLFASMPNFADFYSEESINNQGLECLRFLNE 819
Query: 329 IIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYR--HVTAMADYALRLRE 386
+I+DFD IL + FK I KIK+ G+TYMAASG+T S + G R H++ + ++AL L++
Sbjct: 820 VISDFDAILDQNKFKDIIKIKTIGSTYMAASGITESAESEDGPRWGHLSTLVEFALELKK 879
Query: 387 QLQYVNEHSFNCFRIRIGKSCSPSDA 412
L +NE SFN F +++G + P A
Sbjct: 880 ALSSINEQSFNHFVLKMGINHGPVTA 905
Score = 102 bits (245), Expect = 3e-20
Identities = 53/95 (55%), Positives = 64/95 (67%), Gaps = 3/95 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPV AGVIGARKP YDIWGN VNVASRM+STG + IQVT E IL G+
Sbjct: 897 GINHGPVTAGVIGARKPHYDIWGNTVNVASRMESTGKVGCIQVTDETRKILEPFGFGFEQ 956
Query: 499 RGTVDVKGKGNMVTYFL---EGVGDSIPDDIYNNP 530
RG V VKGKG ++T++L +GV ++ D+ P
Sbjct: 957 RGLVFVKGKGQLLTHYLVSKDGVSLNLDSDLPVEP 991
Score = 51.2 bits (117), Expect = 1e-04
Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 16/195 (8%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+ ++ A V L TE R F+ Q+ E + +E +LL ++LPEHVA
Sbjct: 188 VTLSASAMVLGLSSYSLTEFQQRRAFLETRQSLEVQLVIEEQSTEQERLLLSVLPEHVAV 247
Query: 272 HFLCS-DKNID-QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEI 329
++D QF +++Y + ++V +++A I F+ + E +++LNE+
Sbjct: 248 KMRQDLGASLDTQF--KKIYMSRHENVSILYADIVGFT----AISSTYSASELVKILNEL 301
Query: 330 IADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQ 389
A FD++ E F+ + +IK G Y SG D H L + E ++
Sbjct: 302 FARFDQL--SERFEQL-RIKILGDCYYCISGAPIERPD-----HAVLCVYMGLSMVEAIK 353
Query: 390 YVNEHSFNCFRIRIG 404
YV + + + +R+G
Sbjct: 354 YVQQTTNSPVDMRVG 368
Score = 46.8 bits (106), Expect = 0.002
Identities = 23/79 (29%), Positives = 43/79 (54%), Gaps = 2/79 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G V+AGV+G R+ Q+D++ V +A++M+S+G+ + ++ L+
Sbjct: 368 GIHTGAVLAGVLGQRQWQFDVYSKDVELANKMESSGMAGRVHISNATLSFLNGEFEVEPA 427
Query: 499 RG--TVDVKGKGNMVTYFL 515
G + K +VTYF+
Sbjct: 428 HGEDREEALQKAGIVTYFI 446
>UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7;
Diptera|Rep: Adenylyl cyclase isoform DAC39E - Drosophila
melanogaster (Fruit fly)
Length = 1167
Score = 147 bits (355), Expect = 1e-33
Identities = 82/223 (36%), Positives = 129/223 (57%), Gaps = 12/223 (5%)
Query: 196 DYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQA 255
D++H+ + + ++ + L A +AL ++ + R+ F WK + E+KE ++
Sbjct: 806 DFEHQPII--STRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQ 863
Query: 256 YNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEG 315
N L+ N+LP HVA+HF+ + K +LY + V V+FAS+PNFS+FY E
Sbjct: 864 RNEALVYNVLPVHVAEHFMKNTKR----SHDDLYSQSYAEVGVLFASMPNFSDFYSEETV 919
Query: 316 NNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLT------NSTQDLV 369
NN+G+ECLR LNE+I+DFD +L F+ I KIK+ G+TYMAASG+ N
Sbjct: 920 NNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINLQRTVRNDAPITE 979
Query: 370 GYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDA 412
+ H+ + ++AL L+ LQ +NE SFN F +++G + P A
Sbjct: 980 RWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITA 1022
Score = 107 bits (258), Expect = 8e-22
Identities = 51/88 (57%), Positives = 62/88 (70%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GP+ AGVIGARKP YDIWGN VNVASRM+STG IQVT+E +IL GY
Sbjct: 1014 GINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ 1073
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDDI 526
RG V VKGKG ++T++L+G S + +
Sbjct: 1074 RGLVAVKGKGQLMTFYLQGKSQSSAEPV 1101
Score = 56.0 bits (129), Expect = 3e-06
Identities = 72/296 (24%), Positives = 129/296 (43%), Gaps = 51/296 (17%)
Query: 197 YQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAY 256
Y H L NQ N + A + LL+ E+ + F+ ++ E K +E A
Sbjct: 203 YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAE 262
Query: 257 NRKLLANILPEHVAQHFLCSDKNIDQFDA-QELYHEQCDSVCVMFASIPNFSEFYVELEG 315
+LL ++LP+HVA + D +A +++Y + ++V +++A I F+ +
Sbjct: 263 QERLLLSVLPKHVAIK-MREDLGSSSSEAFKKIYMSRHENVSILYADIVGFT----AISS 317
Query: 316 NNEGVECLRLLNEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHV 374
+ +++LNE+ A FD LAE KY + +IK G Y SG + D H
Sbjct: 318 TYSAQDLVKMLNELFARFDR-LAE---KYQQLRIKILGDCYYCISGAPDERPD-----HA 368
Query: 375 TAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVR 434
L + + ++YV + K+ SP D +RV + G L
Sbjct: 369 VLCVHMGLSMVKAIKYVQQ-----------KANSPVD---------MRVGIHTGAVL--- 405
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
AGI +G R+ Q+D++ V +A++M+S+G + ++ + L+
Sbjct: 406 ---AGI---------LGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLN 449
>UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep:
Adcy3 protein - Mus musculus (Mouse)
Length = 1005
Score = 141 bits (342), Expect = 5e-32
Identities = 67/137 (48%), Positives = 94/137 (68%), Gaps = 5/137 (3%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
S+ E R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K
Sbjct: 858 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----D 912
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYI 345
+ELY + D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I
Sbjct: 913 EELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVI 972
Query: 346 EKIKSTGATYMAASGLT 362
KIK+ G+TYMAASG+T
Sbjct: 973 TKIKTIGSTYMAASGVT 989
Score = 62.5 bits (145), Expect = 4e-08
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A + ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 229 NVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 289 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 344
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 345 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 395
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 396 EAISYVREKTKTGVDMRVG 414
Score = 48.8 bits (111), Expect = 5e-04
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 464
>UniRef50_UPI000155633D Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 301
Score = 136 bits (329), Expect = 2e-30
Identities = 67/94 (71%), Positives = 75/94 (79%), Gaps = 5/94 (5%)
Query: 242 QANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFA 301
QA EEKE+ME LQAYNR+LL NILP+ VA HFL ++ D ELY++ C+ V VMFA
Sbjct: 213 QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRND-----ELYYQSCECVAVMFA 267
Query: 302 SIPNFSEFYVELEGNNEGVECLRLLNEIIADFDE 335
SI NFSEFYVELE NNEGVECLRLLNEIIADFDE
Sbjct: 268 SIANFSEFYVELEANNEGVECLRLLNEIIADFDE 301
>UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1212
Score = 133 bits (321), Expect = 2e-29
Identities = 63/124 (50%), Positives = 87/124 (70%)
Query: 281 DQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEE 340
D+ ++LY V VMFASIPNFSEFY E NN GVEC+RLLNE+I DFDE+LA+
Sbjct: 882 DEKKKEDLYSHSYKRVSVMFASIPNFSEFYSEDNINNGGVECIRLLNEVITDFDEVLADP 941
Query: 341 PFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFR 400
F +EKIK+ +TYMAASGL ++D +++ + D+AL LR++L ++N+ SFN F
Sbjct: 942 RFLGVEKIKTISSTYMAASGLRPESEDAEESQNLVDIVDFALTLRDKLDFINQESFNQFV 1001
Query: 401 IRIG 404
+R+G
Sbjct: 1002 LRVG 1005
Score = 99.1 bits (236), Expect = 4e-19
Identities = 44/79 (55%), Positives = 57/79 (72%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI GP+VAGVIGA+KP YDIWGN VNVASRM++TG IQ+T + Y+ + + +
Sbjct: 1005 GICQGPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQTYETIKDKDFVFVY 1064
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG ++TY+L G
Sbjct: 1065 RGAVRVKGKGQLITYYLTG 1083
Score = 47.2 bits (107), Expect = 0.002
Identities = 24/61 (39%), Positives = 38/61 (62%), Gaps = 2/61 (3%)
Query: 423 VRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
VR E G + RV GI+ G V+AGV+G RK Q++ W N V +A+ M+S G+ + ++
Sbjct: 445 VREEKGVKSLNMRV--GIHTGMVLAGVLGQRKWQFEAWSNDVTLANHMESGGIPGRVHIS 502
Query: 483 Q 483
+
Sbjct: 503 E 503
Score = 45.2 bits (102), Expect = 0.006
Identities = 47/173 (27%), Positives = 76/173 (43%), Gaps = 22/173 (12%)
Query: 241 LQANEEKEDMEHLQAYN---RKLLANILPEHVAQHF---LCSDKNIDQFD--AQELYHEQ 292
L+ E E L A N R+LL ++LP+HVA+ D N D ++L+
Sbjct: 300 LETRESLEVKLTLDAQNQQQRRLLLSVLPKHVAEEMTKDFEGDGNPALTDNAFKKLFIRT 359
Query: 293 CDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTG 352
D+ ++FA I F+ EL + + LNE+ A+FD++ A+ + +IK G
Sbjct: 360 HDTCSILFADIVGFT----ELSSKCTAEQLIVTLNELFANFDKLAAK---NHCLRIKILG 412
Query: 353 ATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEH-SFNCFRIRIG 404
Y SGL +S H + L + E + +V E +R+G
Sbjct: 413 DCYYCISGLDDSC------NHALCAVNMGLDMVEHIAHVREEKGVKSLNMRVG 459
Score = 45.2 bits (102), Expect = 0.006
Identities = 54/255 (21%), Positives = 99/255 (38%), Gaps = 15/255 (5%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGI---IVVSVTYLIF 71
QY E+ M SC ++ V+L + P + + ++ GI ++ T L F
Sbjct: 646 QYALEKQDMCSEALSCLCIIMLCCYFVELA---ILPTSLRSHLVFGIGFLLMFVPTVLTF 702
Query: 72 AIDLKFAGGKLKRISKRVHNN---RTL-AQLMSFIVVGAVILQIQVVMVQEVLGVTNNTN 127
A+ G + +S + + RTL A L ++ GA ++ ++V T
Sbjct: 703 AVKFPQTCGPVLSVSYLLEGSKPARTLVAALCVIVLAGAELIDFLDCSSRDVSSDMIRTW 762
Query: 128 V---PSYENSGGNCPYDMNEHYLQVTLMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXX 184
+ S + + C Y Y + ++ V
Sbjct: 763 INQSKSLDPTSEYCEYPQYFSYNGILILVGISVLVQLSHALKVMLMIGVLIAYWIINLVR 822
Query: 185 QEHLYYRNHFYDYQHRCGLDWNQQWTNIAIALGAT-VALLLHSQQTESTYRLDFIWKLQA 243
Q+ L+ Y Y G + + ++ L T + L LH +Q E T RL F+WK++A
Sbjct: 823 QDKLFVNYDKYVY-FNSGSTFVPKMYFSSVVLALTFIILALHGRQVERTARLLFLWKMEA 881
Query: 244 NEEKEDMEHLQAYNR 258
+E+K++ + +Y R
Sbjct: 882 DEKKKEDLYSHSYKR 896
>UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF13838, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1085
Score = 128 bits (309), Expect = 5e-28
Identities = 89/214 (41%), Positives = 117/214 (54%), Gaps = 36/214 (16%)
Query: 335 EILAEEPFKYIEKIKSTGATYMAASGL--TNSTQDLVGYR-HVTAMADYALRLREQLQYV 391
+++ E ++ IEKIK+ G+TYMAA GL T S Q H+ ++D+A+ + + L +
Sbjct: 848 QLMDRECYRDIEKIKTIGSTYMAAVGLVPTTSAQARKSIAAHLCTVSDFAVDMFDVLDAI 907
Query: 392 NEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIG 451
N S+N F +R+G+ P R E ++V GIN+GPVVAGVIG
Sbjct: 908 NYQSYNDFVLRVGEFRDPHTCPPPLGGGK---RSERQPDVLV----TGINVGPVVAGVIG 960
Query: 452 ARKPQYDIWGNAVNVASRMDSTGLLDHIQVT------------------------QEVYD 487
AR+PQYDIWGN VNVASRMDSTG+ IQV+ Q D
Sbjct: 961 ARRPQYDIWGNTVNVASRMDSTGVPGKIQVSSGFRTHAAPPPAPPPALPPLAFLPQVTED 1020
Query: 488 I--LSARGYKLRCRGTVDVKGKGNMVTYFLEGVG 519
+ L A Y+ CRG V VKGKG M+TYFLEG G
Sbjct: 1021 VHRLIAERYRFVCRGQVTVKGKGQMLTYFLEGRG 1054
Score = 70.9 bits (166), Expect = 1e-10
Identities = 30/57 (52%), Positives = 43/57 (75%)
Query: 221 ALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSD 277
AL LHS+Q + RLD++W QA EE++DME ++ N+++L N+LP HVAQHFL S+
Sbjct: 690 ALALHSRQLDLKLRLDYLWATQAEEERDDMEKVKLDNKRILFNLLPAHVAQHFLLSN 746
Score = 55.2 bits (127), Expect = 6e-06
Identities = 40/139 (28%), Positives = 62/139 (44%), Gaps = 7/139 (5%)
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQEL 288
TE T R F+ EE+ +E +LL ++LP +VA + ++
Sbjct: 104 TERTQRKVFLQARSCIEERLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKI 163
Query: 289 YHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKI 348
Y ++ D+V ++FA I F+ L E ++LLNE+ FDE+ E + +I
Sbjct: 164 YIQRHDNVSILFADIVGFT----SLASQCTAQELVKLLNELFGKFDELATE---NHCRRI 216
Query: 349 KSTGATYMAASGLTNSTQD 367
K G Y SGLT D
Sbjct: 217 KILGDCYYCVSGLTQPKAD 235
Score = 48.4 bits (110), Expect = 7e-04
Identities = 20/52 (38%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+ + L+
Sbjct: 267 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITRTTLECLN 318
>UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|Rep:
CG5983-PA, isoform A - Drosophila melanogaster (Fruit
fly)
Length = 1130
Score = 126 bits (303), Expect = 3e-27
Identities = 101/310 (32%), Positives = 153/310 (49%), Gaps = 26/310 (8%)
Query: 222 LLLHSQQTESTYRLDFIWKLQAN-EEKEDMEHLQAYNRK-LLANILPEHVAQHFLCSDKN 279
L +++++ +S + +KL + + K+ L + LL NILP HV +L S
Sbjct: 799 LTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNS--- 855
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEIL-A 338
ELY+E V VMFA + NF + LR+LN+II FD +L A
Sbjct: 856 ---LAKHELYYENYRMVSVMFAMLINFPM----------NLPSLRVLNDIITQFDRLLTA 902
Query: 339 EEPFKYIEKIKSTGATYMAASGL----TNSTQDLVGYRHVTAMADYALRLREQLQYVNEH 394
+ +EKIK G TYMAA GL ++ + +R+ + + ++ N
Sbjct: 903 YREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYD 962
Query: 395 S-FNCFRIRIGKSCSPSDATASSANCTLRVRVEP-GGALIVRRVPAGINIGPVVAGVIGA 452
S N + + D + A C +L ++ GI+ G ++AGV+GA
Sbjct: 963 SDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGA 1022
Query: 453 RKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVT 512
+P YDIWGN VN+ASRM+STGL HIQVT+E IL K RG VKG+G++ T
Sbjct: 1023 SQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPT 1082
Query: 513 YFLEGVGDSI 522
YF+ G+ +++
Sbjct: 1083 YFV-GIDENL 1091
Score = 50.0 bits (114), Expect = 2e-04
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 423 VRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
VR E G + +R G++ G ++AG+IG K Q+DIWG V +A+ ++STG ++ V+
Sbjct: 398 VRAERGLDIDMR---IGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVS 454
Query: 483 QEVYDILSARGYKL 496
+L+ Y +
Sbjct: 455 GRTLSMLNPADYTI 468
>UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila
melanogaster|Rep: CG32301-PA - Drosophila melanogaster
(Fruit fly)
Length = 1076
Score = 111 bits (267), Expect = 6e-23
Identities = 102/297 (34%), Positives = 148/297 (49%), Gaps = 47/297 (15%)
Query: 245 EEKEDMEHLQAYNRKLL-ANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
E+K ++ ++ K++ ANILP HVA+ F ++ +LY+E V VMFA+I
Sbjct: 768 EKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRS------DQLYYENFSQVAVMFATI 821
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY-IEKIKSTGATYMAASGL- 361
N+ E + G LR L+E+I FDE+L Y IEKIK G TY+AA GL
Sbjct: 822 ENY-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLH 871
Query: 362 -TNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCT 420
+ T V T L+ +++ + I I K P+ AT + + T
Sbjct: 872 VDHYTDFSVSVPISTNRESDKLQKSGSVRFA---PMDGDEIMI-KDLHPTQATTNEDDNT 927
Query: 421 LRVRVEPGGAL--IVR-------------RVPAGINIG----PVVAGVIGARKPQYDIWG 461
+ V E L I+R ++ + IG PV+AGV+G KP YDIWG
Sbjct: 928 ILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWG 987
Query: 462 NAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC--RGTVDVKGKGNMVTYFLE 516
+ VN+ASRM STG+ D I VT+ ++L R + +RC RG VKG G + TY ++
Sbjct: 988 HTVNMASRMTSTGVRDGIHVTESTANVL--RDFNIRCTYRGMTFVKGVGQVPTYLVD 1042
Score = 46.0 bits (104), Expect = 0.004
Identities = 17/51 (33%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G ++AG+IG K Q+DIW V++ +R++S+GL + ++ +L
Sbjct: 382 GVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLL 432
>UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep:
ADCY4 protein - Homo sapiens (Human)
Length = 130
Score = 110 bits (265), Expect = 1e-22
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 35 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 94
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 95 TCYSRGVIKVKGKGQLCTYFL 115
Score = 39.5 bits (88), Expect = 0.32
Identities = 15/37 (40%), Positives = 25/37 (67%)
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
H+ M ++A+ L +L +N+HSFN FR+R+G + P
Sbjct: 8 HLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGP 44
>UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4;
Sophophora|Rep: Adenylyl cyclase isoform DAC9 -
Drosophila melanogaster (Fruit fly)
Length = 1708
Score = 106 bits (254), Expect = 2e-21
Identities = 75/217 (34%), Positives = 122/217 (56%), Gaps = 22/217 (10%)
Query: 203 LDWNQQWTNIAIALGATVALLLH---SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRK 259
+ W Q + ++ I L + L+L +++ E YRL F AN++K +++++
Sbjct: 1297 IKWFQDY-HVEIYLDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADM 1355
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL NI+P+HVA+H KN + Y E ++ ++FASI NF+E Y E G
Sbjct: 1356 LLHNIIPKHVAEHL----KNTAK------YSENHHNIAIIFASIVNFNEMYDE--SYLGG 1403
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
E LR+LNE+I DFDE+L+ F+ +EKIK+ G+T+MAASGL S + G H+ + +
Sbjct: 1404 KEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDPSHRG-TGDEHIHTLME 1462
Query: 380 YALRLREQLQYVNEH--SFNCFRIRIGKSCSPSDATA 414
+++ ++E + N+ FN +RIG + D TA
Sbjct: 1463 FSIAMQEVVDAFNKDLLEFNLI-LRIGMNI--GDVTA 1496
Score = 84.6 bits (200), Expect = 8e-15
Identities = 46/87 (52%), Positives = 57/87 (65%), Gaps = 1/87 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIG V AGVIG K YDIWG+AVNVASRMDSTGL + IQV ++ L+ R Y+
Sbjct: 1488 GMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-YEFEP 1546
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDD 525
RG+V VKGK +M + D+ DD
Sbjct: 1547 RGSVYVKGKDHMEVFLYTTRRDNPLDD 1573
Score = 52.0 bits (119), Expect = 6e-05
Identities = 18/60 (30%), Positives = 39/60 (65%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ G++ G V+ G++G R+ ++D+W N V++A++M+S+G + + ++QE L Y
Sbjct: 446 KMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYY 505
>UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:
ENSANGP00000019838 - Anopheles gambiae str. PEST
Length = 1536
Score = 105 bits (252), Expect = 4e-21
Identities = 74/211 (35%), Positives = 117/211 (55%), Gaps = 18/211 (8%)
Query: 198 QHRCGLDW-NQQWTNIAIALGATVALLLH-SQQTESTYRLDFIWKLQANEEKEDMEHLQA 255
+ R DW N I + L + L+ +++ E YRL F AN++K +++++
Sbjct: 1247 RRRHSFDWFNNYRVEIYVDLLLLLVLVWFLNREFEIGYRLSFHGSAVANQDKIRVQNMKN 1306
Query: 256 YNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEG 315
LL NI+P+HVA+ KN + Y E ++ ++FASI NF+E Y E
Sbjct: 1307 QADMLLHNIIPKHVAEQL----KNTAK------YSENHHNIGIIFASIVNFNEMYDE--S 1354
Query: 316 NNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVT 375
G E LR+LNE+I DFDE+LA F+ +EKIK+ G+T+MAASGL S++ Y H+
Sbjct: 1355 YLGGKEYLRVLNELIGDFDELLARPEFRCVEKIKTIGSTFMAASGLDPSSRGET-YEHLY 1413
Query: 376 AMADYALRLREQLQYVNEH--SFNCFRIRIG 404
+ D+AL +++ ++ N FN +R+G
Sbjct: 1414 TLLDFALAMQQVVESFNRDLLEFNLI-MRVG 1443
Score = 82.6 bits (195), Expect = 3e-14
Identities = 43/79 (54%), Positives = 49/79 (62%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G N G V AGVIG K YDIWG+AVNVASRMDSTG+ +QV + +L R Y
Sbjct: 1443 GYNFGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGVAGRVQVGADCIPVLGER-YDFEP 1501
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGK +M Y L G
Sbjct: 1502 RGKVYVKGKDHMEVYLLVG 1520
Score = 52.4 bits (120), Expect = 4e-05
Identities = 40/150 (26%), Positives = 69/150 (46%), Gaps = 19/150 (12%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS---- 490
++ G++ G V+ G++G ++ ++D+W N V +A+RM+S+G D + V++E L
Sbjct: 444 KMRVGVHTGTVLCGIVGTKRVKFDVWSNDVTLANRMESSGKPDQVHVSEETCGFLGDSYI 503
Query: 491 -ARGYKLRCRGTVDVKGKG-NMVTYFLEG------------VGDSIPDDIYNNPIPSTSS 536
G ++ T V GK ++V EG +G S P + + +S
Sbjct: 504 IEEGEEVDGHRTYFVLGKRLDLVGSITEGLSSIGLPVDLNLLGASSPSCLSRSATNLSSI 563
Query: 537 EGAVPPRPEHRPLDTLSEAHTDEDGGPSPR 566
+ AVPP P+ S H P PR
Sbjct: 564 QPAVPPASPAGPV-FFSSLHASPVSTPRPR 592
>UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 833
Score = 103 bits (246), Expect = 2e-20
Identities = 92/271 (33%), Positives = 137/271 (50%), Gaps = 56/271 (20%)
Query: 247 KEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNF 306
+E++ + + +LL NILP+ + + + Q + Q L E+ D V ++FA + +F
Sbjct: 617 EEELRIEREKSERLLLNILPQKIVE-------TLKQ-EKQGLIAEKYDEVSILFADLVDF 668
Query: 307 SEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
+ L ++ ++LLNEI + FD+ LAE +EKIK+ G YM A+GL +
Sbjct: 669 TALSERLTP----IQLVKLLNEIFSTFDQ-LAEG--LDLEKIKTIGDAYMMAAGLPLPRE 721
Query: 367 DLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVE 426
D H +AD AL +Q V +H F G+ TL++R+
Sbjct: 722 D-----HAETIADMAL----SMQLVVDH----FPFDYGE--------------TLQIRI- 753
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
GI+ G VVAGVIG K YD+WG+ VN+A RM+S+G IQVT VY
Sbjct: 754 ------------GIHTGTVVAGVIGTHKFIYDLWGDTVNIAYRMESSGKPGKIQVTAAVY 801
Query: 487 DILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
+ L Y RG + +KGKG M+TY+L G
Sbjct: 802 ERLK-NEYIFEKRGEIPIKGKGKMMTYWLIG 831
>UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,
isoform A; n=2; Endopterygota|Rep: PREDICTED: similar to
CG9210-PA, isoform A - Tribolium castaneum
Length = 1370
Score = 101 bits (241), Expect = 9e-20
Identities = 70/189 (37%), Positives = 104/189 (55%), Gaps = 17/189 (8%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
V + L +++ E YRL F +N +K ++++L+ L+ NI+PEHVA+
Sbjct: 1109 VLVWLLNREFEIGYRLSFHANYVSNRDKINVQNLKTQADYLIYNIVPEHVAE-------- 1160
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
Q Y E V ++FASI NF+E Y E G E LR+LNE+IADFDE+L
Sbjct: 1161 --QLKKNAKYSENFKDVGIIFASIVNFNEMYDE--SYLGGKEYLRVLNELIADFDELLDR 1216
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQ--DLVGYRHVTAMADYALRLREQLQYVNEH--S 395
F +EKIK+ G+T+MAASGL ++T+ H+ A+ D+AL ++ + N
Sbjct: 1217 PEFASVEKIKTIGSTFMAASGLNSTTRRNQKDPNEHLYALMDFALEMQNVITDFNRDLLE 1276
Query: 396 FNCFRIRIG 404
FN +RIG
Sbjct: 1277 FNLI-LRIG 1284
Score = 83.0 bits (196), Expect = 3e-14
Identities = 43/78 (55%), Positives = 50/78 (64%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G N G V A VIG K YDIWG+AVN+ASRMDSTG+ IQ+ + +L R Y R
Sbjct: 1284 GYNFGEVTAAVIGNTKLYYDIWGDAVNIASRMDSTGVNGCIQIGENCLQVLETR-YVFRP 1342
Query: 499 RGTVDVKGKGNMVTYFLE 516
RG+V VKGK NM Y LE
Sbjct: 1343 RGSVYVKGKDNMSVYLLE 1360
Score = 50.4 bits (115), Expect = 2e-04
Identities = 31/86 (36%), Positives = 49/86 (56%), Gaps = 7/86 (8%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G V+ G++G R+ ++D+W N V +A+RM+STG + V+++ + L Y L
Sbjct: 436 GVHTGTVLCGIVGTRRFKFDVWSNDVTLANRMESTGKPGMVHVSEKTCEFLQDM-YLLE- 493
Query: 499 RGTVDVKGKGNMVTYFLEG-VGDSIP 523
G V G M TYF+ G GD P
Sbjct: 494 EGE-PVLG---MKTYFILGRTGDKTP 515
>UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 545
Score = 101 bits (241), Expect = 9e-20
Identities = 47/80 (58%), Positives = 60/80 (75%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPVVAGVIGA+K YD+WG+ VN+ASRM+S G++ IQVT+ Y L + YK
Sbjct: 466 GINTGPVVAGVIGAKKFIYDLWGDTVNIASRMESHGIIGEIQVTEATYQRLQDK-YKFEK 524
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
RG ++VKGKG M TYFL+G+
Sbjct: 525 RGLINVKGKGEMSTYFLKGI 544
Score = 64.5 bits (150), Expect = 1e-08
Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 22/172 (12%)
Query: 238 IWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC 297
IW+ + K+ +E Q + +LL NILPE +A KN E + + V
Sbjct: 322 IWRSFQSALKQ-LEVEQEKSERLLLNILPESIALRL----KN-----KPETIADNFEEVT 371
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
V+FA I F++ ++ E + LLNEI ++FD+I + +EKIK+ G Y+
Sbjct: 372 VLFADIAGFTQLSAKISPT----ELVNLLNEIFSEFDQITTQ---NNLEKIKTIGDAYLV 424
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
GL N D H A+A AL ++ +L N+ + ++RIG + P
Sbjct: 425 VGGLPNPRSD-----HAEAIAKLALEMQNKLIEFNQKHDHNLQLRIGINTGP 471
>UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
acy-1 - Caenorhabditis elegans
Length = 1253
Score = 100 bits (240), Expect = 1e-19
Identities = 70/208 (33%), Positives = 105/208 (50%), Gaps = 17/208 (8%)
Query: 209 WTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEH 268
W + + + V + + Q E+ +R+ F +QA + E M+ ++ LL N++P H
Sbjct: 971 WELLLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAH 1030
Query: 269 VAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLN 327
+ K Y E ++V V+FASI N+++ Y E EG G E LR+LN
Sbjct: 1031 AVESLKTDTK----------YSENHETVGVLFASITNWNDMYEENFEG---GREFLRVLN 1077
Query: 328 EIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD--LVGYRHVTAMADYALRLR 385
E+I DFDE+L F +IEKIK+ G YMAASGL + L H+ M D+AL ++
Sbjct: 1078 EVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQ 1137
Query: 386 EQLQYVNEHSFNC-FRIRIGKSCSPSDA 412
L NE N F ++G + P A
Sbjct: 1138 HVLSVFNEDLLNFDFVCKLGLNIGPVTA 1165
Score = 91.5 bits (217), Expect = 7e-17
Identities = 50/93 (53%), Positives = 61/93 (65%), Gaps = 3/93 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIGPV AGVIG K YDIWG+ VN+ASRM STG+L+ IQV+Q + L R Y+
Sbjct: 1157 GLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDR-YEFEF 1215
Query: 499 RGTVDVKG-KGNMVTYFLEG-VGDSIPDDIYNN 529
R ++VKG G M TY L G GD IP I +N
Sbjct: 1216 RDHIEVKGIDGGMDTYLLVGRKGDGIPPSIKDN 1248
Score = 44.8 bits (101), Expect = 0.008
Identities = 24/100 (24%), Positives = 57/100 (57%), Gaps = 12/100 (12%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE-------VYDILSA 491
GI+ G V+ G++G ++ ++D++ N V +A+ M+S+G+ + V++ +Y+I
Sbjct: 414 GIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEG 473
Query: 492 RGY----KLRCRGTVDVKGKGNMVTYFLEG-VGDSIPDDI 526
Y +++ +GT +M T+F++G + D + +++
Sbjct: 474 PDYDGPLRMQVQGTERRVKPESMKTFFIKGRINDGVEEEV 513
>UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; n=3;
Bacteria|Rep: Extracellular ligand-binding receptor -
Lyngbya sp. PCC 8106
Length = 1301
Score = 97.5 bits (232), Expect = 1e-18
Identities = 49/83 (59%), Positives = 59/83 (71%), Gaps = 1/83 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GIN GPVVAGVIG RK YD+WG+AVNVASRM+S G IQVT+ YD+L + Y
Sbjct: 1218 RLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVASRMESHGEAGKIQVTKATYDLLKDQ-Y 1276
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
RG +DVKG G M TY+L+G
Sbjct: 1277 IFEKRGIIDVKGIGRMATYWLQG 1299
Score = 60.9 bits (141), Expect = 1e-07
Identities = 48/156 (30%), Positives = 74/156 (47%), Gaps = 21/156 (13%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
Q + +LL NILP +A+ + +I E+ D +MFA I +F+ F ++
Sbjct: 1093 QQKSERLLQNILPRSIAERLKQAPHSIA---------ERFDHATIMFADIVDFTGFSSQI 1143
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
E + LLNEI + FD + +EKIK+ G +YM GL D H
Sbjct: 1144 APT----ELVDLLNEIFSAFDAFAQKHD---LEKIKTIGDSYMVVGGLPTPKDD-----H 1191
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
V A+A+ AL ++ ++ H FR+RIG + P
Sbjct: 1192 VKAIAEMALDMQREICRFQRHDGLPFRLRIGINTGP 1227
>UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmodium
(Vinckeia)|Rep: Guanylyl cyclase, putative - Plasmodium
berghei
Length = 1993
Score = 96.7 bits (230), Expect = 2e-18
Identities = 78/289 (26%), Positives = 135/289 (46%), Gaps = 20/289 (6%)
Query: 239 WKLQANEEKE-----DMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQC 293
++L+ N+ K +E + R++L +LP V + S+ N + L E
Sbjct: 829 YRLEYNQRKNFLLEYSVEASRRKQREILNTMLPPFVVDEMIYSELNEEGIPIS-LKAEDI 887
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
++V ++F I F +E + +L+ + FD+ E F KI++
Sbjct: 888 ETVTIIFCDIYEFQNIVATIEPTR----LVEMLDRLFLCFDK--CTEHFN-CTKIETVFE 940
Query: 354 TYMAASGLTNS-TQDLVGYR---HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
TY+AA GL + D G + D+AL + + ++ ++ N + I+ S
Sbjct: 941 TYLAACGLVKKCSDDNKGNKAKEDAHDSIDFALSILQVSSHI-KYETNKYMIKKENSSEN 999
Query: 410 SDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASR 469
+ + +E I RV GIN G ++AGV+G++KPQY ++G+ VN ASR
Sbjct: 1000 KQLNDNDEDIAKDKALERRPTRI--RVKIGINSGRIIAGVVGSKKPQYALFGDTVNTASR 1057
Query: 470 MDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGV 518
M +TG D+I +++ YD++ + + +VKGKG M TY L V
Sbjct: 1058 MKTTGKPDYIHISEATYDLIKDDKTLIYEKKETEVKGKGIMPTYLLTSV 1106
Score = 36.7 bits (81), Expect = 2.2
Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V GVIG+ + +YD+WG V + M S G+ I V++ + D L
Sbjct: 1839 GLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLM-SNGVPGKINVSETLKDFL 1888
>UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1100
Score = 96.3 bits (229), Expect = 3e-18
Identities = 70/209 (33%), Positives = 110/209 (52%), Gaps = 21/209 (10%)
Query: 210 TNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHV 269
T + L VALL ++Q E R +F +A + K+ + + LL ++ P+HV
Sbjct: 832 TAALVLLWLLVALL--NRQLEMGVRRNFSGDAEAAKVKKKSQVHKQQADWLLLSLFPKHV 889
Query: 270 AQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNE 328
++ SD Y ++ VMFASI NFS+FY E EG G EC+R+LNE
Sbjct: 890 SEALKTSDH----------YSMNYNNAGVMFASIVNFSDFYEENFEG---GKECIRVLNE 936
Query: 329 IIADFDEILAEEPFKYIEKIKS-TGATYMAASGLT---NSTQDLVGYRHVTAMADYALRL 384
++ DFDE+L + +EKIK+ G+T+MA +GL N +++ Y H+ + ++AL +
Sbjct: 937 LVGDFDELLDNIEYMEVEKIKTVNGSTFMAGAGLNQEDNIRREIHPYEHLKQLVEFALEM 996
Query: 385 REQLQYVNEHSFNC-FRIRIGKSCSPSDA 412
+ NEH F++RIG + P A
Sbjct: 997 FNVVDRFNEHMLGFKFKLRIGFNAGPVTA 1025
Score = 82.6 bits (195), Expect = 3e-14
Identities = 41/79 (51%), Positives = 53/79 (67%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G N GPV AGVIG K YDIWG+ VN+ASRMDSTG+ + IQV++ ++L+ +
Sbjct: 1017 GFNAGPVTAGVIGTTKLLYDIWGDTVNLASRMDSTGVPEKIQVSESTKEMLN-DFFIFER 1075
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RGT+ VKGKG + TY G
Sbjct: 1076 RGTIPVKGKGYVTTYLYLG 1094
Score = 50.0 bits (114), Expect = 2e-04
Identities = 21/79 (26%), Positives = 41/79 (51%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G V+ G++G ++ ++D+W N V +A+RM++ GL + +T+ L +
Sbjct: 386 GVHTGTVLCGIVGTKRFKFDVWSNDVTLANRMETAGLPGRVHITEATVGFLRDQYIVENG 445
Query: 499 RGTVDVKGKGNMVTYFLEG 517
G + TYF+ G
Sbjct: 446 HGETRNAALKGITTYFIVG 464
Score = 41.1 bits (92), Expect = 0.10
Identities = 27/111 (24%), Positives = 52/111 (46%), Gaps = 12/111 (10%)
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
++V ++FA I F++ + N + +RLLN++ FD + + + EKI + G
Sbjct: 288 ENVSILFADIVGFTK----MSSNKSADQLVRLLNDLFGRFDRL---TEYNHCEKISTLGD 340
Query: 354 TYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
Y +G T + H T + L + EQ++ + + N +R+G
Sbjct: 341 CYYCVAGCPKPTPN-----HATYCVEMGLDMLEQIKEFDNDTDNDVDMRVG 386
>UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1597
Score = 96.3 bits (229), Expect = 3e-18
Identities = 85/296 (28%), Positives = 143/296 (48%), Gaps = 58/296 (19%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E+++ + +A + KLL ILP + +KNI F S ++F I
Sbjct: 1332 EQQKQADAAKATSEKLLYQILPRDIVVQINRGEKNIS-FTVS--------SASIVFIDIV 1382
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FS++ L E + L+ D I+A+ F + KIK G YMAA GL N
Sbjct: 1383 KFSDYSSSLTPQ----EIMANLSHYFNTLDTIMAK--FDLLTKIKLIGDIYMAAGGLFNP 1436
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVR 424
+L +H M ++ + +L+ +N +R+ NC+L VR
Sbjct: 1437 --ELPPQKHAEQMVLFSTEVIGELEEIN--------LRL--------------NCSLSVR 1472
Query: 425 VEPGGALIVRRVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
V G+N G P++AGV+G KP +DI G+ +N+ASR+ ST + +H+Q++Q
Sbjct: 1473 V-------------GVNTGGPIIAGVLGKDKPVFDIIGDPINIASRLQSTDIANHVQISQ 1519
Query: 484 EVYDILSARGYKLRCRGTVDVKGKGNMVTYFLE--GVGDSIPDDIYNNPIPSTSSE 537
Y++++ ++ RG V +KGKG+ +TY + + DS+ D+ PI ++S+
Sbjct: 1520 STYEMINHLNLNVKPRGEVFLKGKGSQMTYLVSPPNLQDSLELDV---PIQMSNSQ 1572
>UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 358
Score = 95.5 bits (227), Expect = 5e-18
Identities = 44/84 (52%), Positives = 60/84 (71%), Gaps = 1/84 (1%)
Query: 433 VRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
+ + GIN GPVVAGVIG +K YD+WG+AVN+ASRM+S G + IQV+ Y++L +
Sbjct: 263 ILNIRIGINTGPVVAGVIGLKKFSYDLWGDAVNIASRMESHGKIGEIQVSSSTYELLKHK 322
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLE 516
Y L RG V VKG+G M+TY+L+
Sbjct: 323 -YVLEKRGIVQVKGRGEMITYWLK 345
Score = 51.2 bits (117), Expect = 1e-04
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 23/154 (14%)
Query: 257 NRKLLANILPEHVAQHFLCSDKNIDQFDAQE-LYHEQCDSVCVMFASIPNFSEFYVELEG 315
+ +LL NILP+ +A+ Q Q L ++ + ++FA I +F+ ++
Sbjct: 143 SEQLLLNILPQAIAE----------QLKKQPGLIADRFEQATILFADITDFTGLASQISP 192
Query: 316 NNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVT 375
E + LLN+I + FD LAE +EKIK+ G YM GL D H
Sbjct: 193 T----ELVSLLNQIFSSFDR-LAER--HGLEKIKTIGDAYMVVGGLPKPRTD-----HAE 240
Query: 376 AMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
A+AD AL +++++ IRIG + P
Sbjct: 241 AIADMALDMQQEIYRFKREDNKILNIRIGINTGP 274
>UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 442
Score = 95.1 bits (226), Expect = 6e-18
Identities = 47/79 (59%), Positives = 56/79 (70%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI IGPVVAGVIG RK YD+WG+ VN+ASRM+S G+ + IQVT+ Y L Y L
Sbjct: 362 GIAIGPVVAGVIGLRKFIYDLWGDTVNIASRMESHGIANEIQVTETTYHALK-DDYSLEK 420
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RGT+ VKGKG M TY L+G
Sbjct: 421 RGTILVKGKGEMTTYLLKG 439
Score = 51.6 bits (118), Expect = 7e-05
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 234 RLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQC 293
R +F +L E + ++ Q + L+ NILP +AQ + Q +
Sbjct: 212 RSEFNSRLALEEAYQQLQVEQERSEALILNILPVPIAQR-------LKQKPVTTIADNFT 264
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
D+ V+F I F+E L G E ++LL +I + FD LA++ +EKIK+ G
Sbjct: 265 DAG-VLFGDIVGFTE----LSGKMPPAELVQLLGQIFSRFDH-LADK--HNLEKIKTIGD 316
Query: 354 TYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
YM SGL +D + +AD AL +++ + N + F++RIG + P
Sbjct: 317 AYMVVSGLPIPKED-----YAERIADMALDMQKTILEFNAETERKFQMRIGIAIGP 367
>UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl
cyclase 35C CG9210-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Adenylyl cyclase
35C CG9210-PA, isoform A - Apis mellifera
Length = 729
Score = 94.7 bits (225), Expect = 8e-18
Identities = 71/221 (32%), Positives = 113/221 (51%), Gaps = 18/221 (8%)
Query: 205 WNQQWTNIAIALGATVALLLH---SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLL 261
++++ N I L + LLL +++ E +YRL F A +K ++ ++ LL
Sbjct: 448 YHERLYNSEIFLDMILLLLLVWFLNREFEISYRLSFHGNAVAARDKTRVQSMKNQADWLL 507
Query: 262 ANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
NI+P++VA DQ Y + +V ++FASI NF+E Y E G E
Sbjct: 508 HNIIPKYVA----------DQLKTTAKYSQNHKAVGIIFASIVNFNELYDE--SYLGGKE 555
Query: 322 CLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST--QDLVGYRHVTAMAD 379
LR+LNE+I DFDE+L + F +EKIK+ G+T+MAASGL Q+ Y+H+ + D
Sbjct: 556 YLRVLNELIGDFDELLEKPEFSNVEKIKTIGSTFMAASGLNPQVRQQNEHEYKHLFQLID 615
Query: 380 YALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCT 420
+A+ L + + N F++ + + D TA T
Sbjct: 616 FAMTLHKVINDFNRDLLG-FKLILRIGFNYGDVTAGVIGAT 655
Score = 94.3 bits (224), Expect = 1e-17
Identities = 49/84 (58%), Positives = 56/84 (66%), Gaps = 1/84 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G N G V AGVIGA K YDIWG+AVN+ASRMDSTG+ IQV + V D+LS R Y+
Sbjct: 641 GFNYGDVTAGVIGATKLYYDIWGDAVNIASRMDSTGVAGRIQVAKNVLDVLSER-YEFEP 699
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSI 522
RG V VKGK NM + L G D I
Sbjct: 700 RGQVYVKGKDNMDVFLLIGKKDDI 723
>UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1;
Beggiatoa sp. PS|Rep: Adenylate/guanylate cyclase -
Beggiatoa sp. PS
Length = 430
Score = 93.1 bits (221), Expect = 2e-17
Identities = 44/83 (53%), Positives = 59/83 (71%), Gaps = 1/83 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G VVAGVIG +K YD+WG+ VN ASRM+S G+ IQV+ VYD L + Y
Sbjct: 346 KIRIGIHNGAVVAGVIGLKKFAYDLWGDTVNTASRMESHGIAGCIQVSNRVYDALEDK-Y 404
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
L RGT+++KGKG M+TY L+G
Sbjct: 405 VLTKRGTIEIKGKGEMITYMLKG 427
Score = 55.6 bits (128), Expect = 4e-06
Identities = 51/175 (29%), Positives = 79/175 (45%), Gaps = 21/175 (12%)
Query: 230 ESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELY 289
E + +F + E ++ Q + +LL NILP +AQ K +Q A
Sbjct: 197 ERLQKAEFEARFALQTEHGALKVEQEKSERLLLNILPLSIAQRL----KQEEQIIADHF- 251
Query: 290 HEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIK 349
+V V+FA I F++ L + + LLNEI + FD+++ + +EKIK
Sbjct: 252 ----TNVTVLFADIVGFTQLSERLSAK----KLVELLNEIFSTFDKLVEKHG---LEKIK 300
Query: 350 STGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+ G YM GL +D VT +A+ AL ++E L N +IRIG
Sbjct: 301 TIGDAYMVVGGLPVPIED-----SVTPIAEMALDMQEALAQFNRRYHYDLKIRIG 350
>UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate
cyclase type ix; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to adenylate cyclase type ix - Nasonia
vitripennis
Length = 1314
Score = 92.3 bits (219), Expect = 4e-17
Identities = 67/215 (31%), Positives = 112/215 (52%), Gaps = 18/215 (8%)
Query: 205 WNQQWTNIAIALGATVALLLH---SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLL 261
+N++ N I L + LLL +++ E +YRL F A +K ++ ++ LL
Sbjct: 1041 YNERLYNSEIFLDLALLLLLVWFLNREFEISYRLSFHGNAVAARDKSRVQSMKNQADWLL 1100
Query: 262 ANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
NI+P++VA DQ Y + +V ++FA+I NF+E Y E G E
Sbjct: 1101 HNIIPKYVA----------DQLKTTAKYSQNHKAVGIIFATIVNFNELYDE--SYLGGKE 1148
Query: 322 CLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST--QDLVGYRHVTAMAD 379
LR+LNE+I DFDE+L ++ + +EKIK+ G+T+MAASGL Q + H+ + D
Sbjct: 1149 YLRVLNELIGDFDELLEKQDYSNVEKIKTIGSTFMAASGLNPQVRQQSEHEHTHIYQLLD 1208
Query: 380 YALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATA 414
+A+ + + + N+ F++ + + D TA
Sbjct: 1209 FAMAMHKVIYDFNQDLLG-FKLILRVGFNFGDVTA 1242
Score = 85.8 bits (203), Expect = 4e-15
Identities = 45/89 (50%), Positives = 56/89 (62%), Gaps = 3/89 (3%)
Query: 429 GALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
G ++ RV G N G V AGVIG+ K YDIWG+AVN+ASRMDSTG+ IQ D+
Sbjct: 1226 GFKLILRV--GFNFGDVTAGVIGSSKLYYDIWGDAVNIASRMDSTGVAGEIQFASNCLDV 1283
Query: 489 LSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ R Y RG V VKGK NM + L+G
Sbjct: 1284 IAER-YNYEPRGQVYVKGKDNMNVFLLKG 1311
Score = 44.8 bits (101), Expect = 0.008
Identities = 14/51 (27%), Positives = 34/51 (66%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ G++G ++ ++D+W N V +A++++STG + ++++ L
Sbjct: 458 GVHTGTVLCGIVGTKRFKFDVWSNDVTLANKLESTGKPGRVHLSEKTLSFL 508
>UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 657
Score = 92.3 bits (219), Expect = 4e-17
Identities = 44/77 (57%), Positives = 55/77 (71%), Gaps = 1/77 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GPVVAGVIG K YD+WG+ VNVASRM+S G+ IQVT EVY+ L + +
Sbjct: 578 GIHAGPVVAGVIGLSKFSYDLWGDTVNVASRMESNGVSGQIQVTSEVYERLKDQ-FVFAL 636
Query: 499 RGTVDVKGKGNMVTYFL 515
RG++ +KGKG M TYFL
Sbjct: 637 RGSIPIKGKGEMTTYFL 653
Score = 56.8 bits (131), Expect = 2e-06
Identities = 46/169 (27%), Positives = 77/169 (45%), Gaps = 21/169 (12%)
Query: 241 LQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMF 300
+Q + +++++ + KLL NILP+ +A+ I + V V+F
Sbjct: 436 IQRKQAQQELQSQKEQTEKLLLNILPQPIAERLQKQPGIIADY---------FQDVSVLF 486
Query: 301 ASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASG 360
A + F++F E + L +LN I + FD++ +EKIK+ G YM G
Sbjct: 487 ADLVGFTDFSSEA----TPAQILEILNSIFSHFDQL---SQHYGLEKIKTIGDAYMVVGG 539
Query: 361 LTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
L +D H+ A+A AL ++ L N+ + N F +RIG P
Sbjct: 540 LPLYHRD-----HLHAIAKMALDMQTNLTQFNQQTGNNFLLRIGIHAGP 583
>UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p -
Drosophila melanogaster (Fruit fly)
Length = 1162
Score = 91.9 bits (218), Expect = 6e-17
Identities = 93/368 (25%), Positives = 157/368 (42%), Gaps = 34/368 (9%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLA----FNMTPIGIATMILCGIIVVSVTYLI 70
QY E D MLK + + V+Y +L +QLL+ ++ I T+IL ++++ Y
Sbjct: 604 QYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIVSWYKK 663
Query: 71 FAI------DLKFAGGKLKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTN 124
I D+ G+L R+ + ++ ++ +I V + +V+G ++
Sbjct: 664 LWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSS 723
Query: 125 NTNVPSYENSGGNCPYDMNEHYLQVTLMAMFLCAVHQIXXXXXXXXXXXXXXXXXXXXXX 184
+ + + + YD ++ + V +
Sbjct: 724 DEDYADLDPT-----YDERVQCFHPWILTNCMTLVISMSFLFTRIPFIIKSCFSALIMIG 778
Query: 185 QEHLYYR--NHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQ 242
L N Y +++N ++++I + + L +QTE ++D+ WK Q
Sbjct: 779 YAVLVVSEFNFIYANSPSTNVNFNAKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQ 838
Query: 243 ANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFAS 302
+++ED + LL NILP HVA +L + ELY+E+ D+V VMFAS
Sbjct: 839 LIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQ------NELYYEEYDNVAVMFAS 892
Query: 303 IPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE-EPFKYIEKIKSTGATYMAASGL 361
I NF + LR+LNEII DFD++L + +EKIK TYMAA GL
Sbjct: 893 IKNFDTDKIG----------LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGL 942
Query: 362 TNSTQDLV 369
S + V
Sbjct: 943 DVSRSEQV 950
Score = 83.0 bits (196), Expect = 3e-14
Identities = 44/98 (44%), Positives = 60/98 (61%), Gaps = 4/98 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T ++ E G+ + GI+ G +AGV+G KP YDIWGN VN+ASRMDSTG+ I
Sbjct: 1047 TENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQI 1106
Query: 480 QVTQEVYDILSARGYKLRC--RGTVDVKGKGNMVTYFL 515
QVT+ L R + ++C RG VKG+GN+ TY +
Sbjct: 1107 QVTENT--ALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
Score = 52.4 bits (120), Expect = 4e-05
Identities = 21/51 (41%), Positives = 36/51 (70%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V++GVIGA K Q+DIW V++A+R+++TG + V+Q+ +L
Sbjct: 422 GVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLL 472
>UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; n=1;
Trichodesmium erythraeum IMS101|Rep: Adenylate/guanylate
cyclase precursor - Trichodesmium erythraeum (strain
IMS101)
Length = 1209
Score = 91.1 bits (216), Expect = 1e-16
Identities = 44/79 (55%), Positives = 56/79 (70%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPVVAGVIG +K YD+WG+ VN+ASRM+S G+ IQVT+ Y IL + +
Sbjct: 1127 GINTGPVVAGVIGRKKFIYDLWGDTVNIASRMESQGIPGVIQVTEATYQILKHK-FLFTE 1185
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + +KGKG M TYFL+G
Sbjct: 1186 RGLIHIKGKGYMKTYFLQG 1204
Score = 57.6 bits (133), Expect = 1e-06
Identities = 54/157 (34%), Positives = 78/157 (49%), Gaps = 23/157 (14%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
Q + KLL NILP+ +A DK + Q++ E D V V+FA + F++ L
Sbjct: 998 QGKSEKLLLNILPKPIA------DKLKEN---QDIIAEGFDEVTVLFADLVGFTQ----L 1044
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKY-IEKIKSTGATYMAASGLTNSTQDLVGYR 372
+ + LNEI + FD +LAE KY +EKIK+ G YM GL ++
Sbjct: 1045 ASSVYPKRLVYWLNEIFSKFD-LLAE---KYGLEKIKTIGDAYMVVGGLPTPMEN----- 1095
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
H A+A A+ +RE+L + S F IRIG + P
Sbjct: 1096 HAEAIALIAIDMREELAHFAHKSKQDFLIRIGINTGP 1132
>UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 2 beta -
Limax marginatus
Length = 406
Score = 90.6 bits (215), Expect = 1e-16
Identities = 46/101 (45%), Positives = 65/101 (64%), Gaps = 4/101 (3%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ GPVVAGV+G R P+Y ++G+ VN ASRM+S G+ I ++ + L +GY
Sbjct: 154 QIRVGIHTGPVVAGVVGVRMPRYCLFGDTVNTASRMESHGMPGRIHLSPSTFQALEGQGY 213
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGD---SIP-DDIYNNPI 531
+CRG +KGKG MVTYFL G + S P D+I N P+
Sbjct: 214 TCKCRGETLIKGKGCMVTYFLLGDQNHTISEPEDEIRNIPV 254
>UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4;
Burkholderiaceae|Rep: Adenylate/guanylate cyclase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 395
Score = 90.2 bits (214), Expect = 2e-16
Identities = 84/264 (31%), Positives = 121/264 (45%), Gaps = 49/264 (18%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
Q + +LL N+LP +A+ +I E+ ++ V V+FA I +F+ F +
Sbjct: 174 QKVSERLLLNMLPYPIAERLKVHLDDIAG-SFPEVIADRFADVSVLFADIVDFTGFSAGM 232
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
+ + +LNEI FD I +EKIK+ G YMAA+GL D H
Sbjct: 233 RPE----QLVEMLNEIFTGFDTIADHCG---LEKIKTIGDAYMAAAGLPVPAAD-----H 280
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIV 433
T A AL + + L FN R +C L++R+
Sbjct: 281 ATRAAHMALDMIDALA-----RFNAAR-----------------HCNLKLRI-------- 310
Query: 434 RRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
GIN G VVAGVIG RK YD+WG AVN+ASRM+S G+ +QVT + ++
Sbjct: 311 -----GINSGEVVAGVIGKRKFIYDLWGAAVNLASRMESQGVAGRVQVT-DATRVMLGEA 364
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEG 517
+ RG + KG G T+F+ G
Sbjct: 365 FVFEERGLIAAKGMGEFRTWFVVG 388
>UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|Rep:
Guanylate cyclase - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 859
Score = 89.8 bits (213), Expect = 2e-16
Identities = 47/99 (47%), Positives = 64/99 (64%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T R+ +P L +R AGI+ GPVVAGV+G + P+Y ++G+ VN ASRM+ST I
Sbjct: 720 TFRIPHKPSMQLQIR---AGIHSGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSTALKI 776
Query: 480 QVTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFLEG 517
Q + + +L GY L CRG VKGKG+MVTY+L+G
Sbjct: 777 QCSSSTFYLLEEIGGYVLECRGVQQVKGKGDMVTYWLQG 815
>UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3;
Oscillatoriales|Rep: Adenylate cyclase - Spirulina
platensis
Length = 671
Score = 89.4 bits (212), Expect = 3e-16
Identities = 45/83 (54%), Positives = 57/83 (68%), Gaps = 1/83 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GIN G VVAGVIG +K YD+WG+AVN+ASRM+S+G IQVT+E Y L Y
Sbjct: 582 QIRIGINTGAVVAGVIGIKKFIYDLWGDAVNIASRMESSGTPGSIQVTEETYHRLK-YNY 640
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
+ RG + VKGKG M TY+L G
Sbjct: 641 IFKKRGLIPVKGKGQMTTYWLLG 663
Score = 47.2 bits (107), Expect = 0.002
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 24/151 (15%)
Query: 257 NRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGN 316
+ +LL N+LP+ +A + K I + V ++FA I F+ L
Sbjct: 457 SEELLLNVLPKPIADQLKANKKAIAS---------AIEEVTILFADIVGFTP----LSAR 503
Query: 317 NEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTA 376
+ +E + LLNE+ + FD LA++ +EKIK+ G YM GL L H A
Sbjct: 504 MDPIELVSLLNEMFSIFDN-LADK--HKLEKIKTIGDAYMVVGGL-----PLPQNNHAEA 555
Query: 377 MADYALRLR---EQLQYVNEHSFNCFRIRIG 404
+AD AL ++ +Q Q F+IRIG
Sbjct: 556 IADMALEMQAAMKQFQGSYLMGSESFQIRIG 586
>UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1;
Methylobacillus flagellatus KT|Rep: Adenylate/guanylate
cyclase - Methylobacillus flagellatus (strain KT / ATCC
51484 / DSM 6875)
Length = 426
Score = 89.4 bits (212), Expect = 3e-16
Identities = 45/88 (51%), Positives = 60/88 (68%), Gaps = 1/88 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G VVAG+IG + YD+WG+AVN+ASRM++TGL + IQV+ Y++L A Y
Sbjct: 338 GMNSGAVVAGIIGNTRFSYDLWGDAVNIASRMETTGLPNEIQVSAATYELLKA-DYCFEP 396
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDDI 526
R VDVKGKG +VTY L+G D D+
Sbjct: 397 RCGVDVKGKGKVVTYLLKGRMDKHDVDV 424
Score = 46.8 bits (106), Expect = 0.002
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 20/148 (13%)
Query: 257 NRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGN 316
+ +LL +ILPE VA K + + + D+V ++FA I NF++ +
Sbjct: 211 SEQLLRSILPESVA-------KRLHETQCGRIADSH-DAVTILFADIVNFTQ----ISAG 258
Query: 317 NEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTA 376
+ LLN + + FD++ A+ +EKIK+ G YM +G + D H
Sbjct: 259 MTPAAVVDLLNHVFSRFDQLAAQYG---VEKIKTIGDAYMVIAGAPSPRTD-----HAHV 310
Query: 377 MADYALRLREQLQYVNEHSFNCFRIRIG 404
MAD AL + L V+ +RIG
Sbjct: 311 MADMALEVPALLDKVSREIGMPLAMRIG 338
>UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1276
Score = 89.0 bits (211), Expect = 4e-16
Identities = 44/88 (50%), Positives = 62/88 (70%), Gaps = 2/88 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
G++ G VVAGV+G++ P+Y ++G+ VN +SRM+S GL I V+Q+ YDIL G+KL
Sbjct: 1183 GMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLE 1242
Query: 498 CRGTVDVKGKGNMVTYFLEGVGD-SIPD 524
RG+V++KGKG TY+L G D IPD
Sbjct: 1243 LRGSVEMKGKGMQTTYWLRGYKDVEIPD 1270
Score = 35.9 bits (79), Expect = 3.9
Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 14/116 (12%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E D V + F+ I F+ L + ++ + LLN++ FD ++ + FK + K+++
Sbjct: 1080 ESYDCVTIYFSDIVGFTS----LSSQSTPMQVVTLLNDLYLAFDGVV--DNFK-VYKVET 1132
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQ-YVNEH-SFNCFRIRIG 404
G YM SGL D H +A +L L +++ +V H ++RIG
Sbjct: 1133 IGDAYMVVSGLPERRDD-----HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIG 1183
>UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Plasmodium vivax|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Plasmodium vivax
Length = 3979
Score = 89.0 bits (211), Expect = 4e-16
Identities = 83/313 (26%), Positives = 146/313 (46%), Gaps = 41/313 (13%)
Query: 239 WKLQANEEKE-----DMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQC 293
++L+ N+ K +E + R++L +LP V + S+ N + L E
Sbjct: 2770 YRLEYNQRKNFLLEYSVESSRRKQREILNTMLPPFVVDEMIYSELNEEGIPIS-LKAEDI 2828
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
++V ++F I +F +E + +L+ + FD+ E F KI++
Sbjct: 2829 ETVTIIFCDIYDFQNIVASIEPTR----LVEVLDRLFLCFDK--CTEQFN-CTKIETVFE 2881
Query: 354 TYMAASGLT----NSTQDLVGYRHVTAMADYALRLREQLQYVN----EHSF----NCFR- 400
TY+AA GL + +++ G + D+AL + + ++ +H F +C
Sbjct: 2882 TYLAACGLVKKEGSESKENKGQQDAHDSIDFALSILQVSSHIKYERTKHMFKRGDSCGSG 2941
Query: 401 ------------IRIGKSCSPSDATASS-ANCTLRVRVEPGG-ALIVR-RVPAGINIGPV 445
I G + + ++A A++ AN GG R RV GIN G +
Sbjct: 2942 AEGSQEAAKKDVITSGGANAATNANAANIANTANAANSANGGEGRPARIRVKIGINSGRI 3001
Query: 446 VAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVK 505
+AGV+G++KPQY ++G+ VN ASRM +TG D+I +++ YD++ + + ++K
Sbjct: 3002 IAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYDLVKDDKTLVYEKKETEIK 3061
Query: 506 GKGNMVTYFLEGV 518
GKG M TY L V
Sbjct: 3062 GKGTMTTYLLTSV 3074
Score = 39.9 bits (89), Expect = 0.24
Identities = 18/51 (35%), Positives = 31/51 (60%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V GVIG+ + +YD+WG V + M+S G+ I V++ + + L
Sbjct: 3823 GLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLMESNGVPGKINVSETLKNFL 3873
>UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 622
Score = 88.2 bits (209), Expect = 7e-16
Identities = 42/92 (45%), Positives = 61/92 (66%)
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
+P G R+ GI+ G VVAGV+G + P+Y ++G+ VN ASRM+STGL I V+++
Sbjct: 531 DPAGLNDHLRIRIGIHTGTVVAGVVGLKMPRYCLFGDTVNTASRMESTGLAMAIHVSEDT 590
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
L+ Y L+ RG++D+KGKG M TY+L G
Sbjct: 591 QKFLAKANYALKQRGSMDIKGKGGMKTYWLLG 622
>UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15;
Mycobacterium|Rep: Adenylate cyclase - Mycobacterium
bovis
Length = 443
Score = 88.2 bits (209), Expect = 7e-16
Identities = 48/92 (52%), Positives = 64/92 (69%), Gaps = 3/92 (3%)
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
+P G + RV G+ GPVVAGV+G+R+ YD+WG+AVNVASRM+ST + IQV EV
Sbjct: 335 DPRGNPVPLRV--GLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEV 392
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
Y+ L + LR RG ++VKGKG M T++L G
Sbjct: 393 YERLK-DDFVLRERGHINVKGKGVMRTWYLIG 423
Score = 53.6 bits (123), Expect = 2e-05
Identities = 43/160 (26%), Positives = 74/160 (46%), Gaps = 20/160 (12%)
Query: 250 MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEF 309
ME + LLAN+LP +A+ ++NI ++ D V+FA I F+E
Sbjct: 212 MEAEHDRSEALLANMLPASIAERLKEPERNI--------IADKYDEASVLFADIVGFTE- 262
Query: 310 YVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLV 369
+ + +R L+ + + FDE++ + +EKIK +G +YM SG+ D
Sbjct: 263 ---RASSTAPADLVRFLDRLYSAFDELVDQHG---LEKIKVSGDSYMVVSGVPRPRPD-- 314
Query: 370 GYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
H A+AD+AL + + + N +R+G + P
Sbjct: 315 ---HTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGP 351
>UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 491
Score = 87.8 bits (208), Expect = 9e-16
Identities = 40/79 (50%), Positives = 56/79 (70%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GPV+AG+IG +K YD+WG+AVN ASRM+S G+ IQ+T+ +D L + +
Sbjct: 404 GINSGPVIAGIIGTKKFIYDLWGDAVNTASRMESHGIAGEIQLTETTFDYLQ-KEFLFVE 462
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG +++KGKG M TY L+G
Sbjct: 463 RGLIEIKGKGKMRTYLLKG 481
Score = 58.8 bits (136), Expect = 5e-07
Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 21/161 (13%)
Query: 249 DMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSE 308
++ + Q + +LL +ILP+ +A + NI A+ ++FA I F+
Sbjct: 270 ELSNEQKKSEELLLSILPQSIANRLKNGEVNIADCFAE---------ATILFADIVGFTT 320
Query: 309 FYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDL 368
E++ + +R+LNEI +DFD + + +K +EKIK+ G YM GL N +D
Sbjct: 321 LSKEVKPE----KVVRILNEIFSDFDRLC--DRYK-LEKIKTIGDAYMVVGGLPNPRKD- 372
Query: 369 VGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
H A+A+ AL + + L N + IRIG + P
Sbjct: 373 ----HAAAIAEMALDMLDDLNQFNAKNNVKLEIRIGINSGP 409
>UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, family
3 (some proteins contain HAMP domain); n=1; Nostoc
punctiforme PCC 73102|Rep: COG2114: Adenylate cyclase,
family 3 (some proteins contain HAMP domain) - Nostoc
punctiforme PCC 73102
Length = 433
Score = 87.4 bits (207), Expect = 1e-15
Identities = 42/80 (52%), Positives = 55/80 (68%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GPVVAGVIG +K YD+WG+ VN ASRM+S G+ +IQV + Y +L + Y
Sbjct: 351 GISTGPVVAGVIGLKKFAYDLWGDTVNTASRMESHGIAGNIQVCEATYQLLKDK-YLFDK 409
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
RG + VKGKG M+TY L+ V
Sbjct: 410 RGLIQVKGKGEMMTYILKKV 429
Score = 64.5 bits (150), Expect = 1e-08
Identities = 55/163 (33%), Positives = 78/163 (47%), Gaps = 21/163 (12%)
Query: 247 KEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNF 306
++ ME Q + +LL NILP +A+ I + + E V V+FA I F
Sbjct: 215 RKAMELAQQKSERLLLNILPGMIAEQLKQQPTTI-----ADSFME----VTVLFADIVGF 265
Query: 307 SEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
+E L E + LLN I FD+ LAE +EKIK+ G YMA +GL N ++
Sbjct: 266 TE----LSARTSPTELVELLNTIFCLFDQ-LAE--LHKVEKIKTIGDAYMAVAGLPNQSK 318
Query: 367 DLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
D H A+A+ AL ++ + N + F IRIG S P
Sbjct: 319 D-----HALAIANMALDMQNAIAIFNAENNQLFSIRIGISTGP 356
>UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1593
Score = 87.4 bits (207), Expect = 1e-15
Identities = 76/270 (28%), Positives = 127/270 (47%), Gaps = 51/270 (18%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+++ E +A + KLL ILP + + +I+ F S ++F I
Sbjct: 1348 QRKSAEQAKAQSEKLLFQILPRDIVTRLNSGETDIN-FTVP--------SATIIFIDIVK 1398
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
FS + L + + L+ I A FD ++A+ + I KIK G YMAA+GL +
Sbjct: 1399 FSNYAATLSP----AQIMDHLSIIFAKFDTLVAK--YNLITKIKLIGDVYMAAAGLFGT- 1451
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRV 425
D+ +H + M ++AL E L ++E + N F ++N R+ +
Sbjct: 1452 -DIAPEKHASQMVNFAL---ESLTALDEAN-NMF----------------NSNLMTRIGI 1490
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
G LI AGV+G KP +DI G+ +NVASR+ STG+ +Q+++E
Sbjct: 1491 NTNGPLI--------------AGVLGTDKPVFDIIGDPINVASRLQSTGIPGTVQISEET 1536
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
Y ++ Y + RG +++KGKG + Y +
Sbjct: 1537 YKLIVNMNYNIERRGEIELKGKGKKMAYIV 1566
>UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep: CG32305-PA
- Drosophila melanogaster (Fruit fly)
Length = 1102
Score = 87.0 bits (206), Expect = 2e-15
Identities = 43/79 (54%), Positives = 56/79 (70%), Gaps = 4/79 (5%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G V+AGV+G KP YDIWG+ VN+ASRM STGLLD+IQVT+ +L R + +RC
Sbjct: 943 GISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL--RQFNIRC 1000
Query: 499 --RGTVDVKGKGNMVTYFL 515
RG +VKG G + TY +
Sbjct: 1001 NYRGHTEVKGVGKVPTYLV 1019
Score = 68.9 bits (161), Expect = 5e-10
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 18/176 (10%)
Query: 187 HLYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEE 246
HLYY ++ L + + + + L+L + + ++ ++ E
Sbjct: 689 HLYY-GFAFERSETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEA 747
Query: 247 KEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNF 306
+ + + ++ANILP HVAQ + + +LY+E V VMFASI NF
Sbjct: 748 HQQTDEKLRSIKIIMANILPTHVAQVYKVRRPH------DQLYYENFSKVAVMFASIENF 801
Query: 307 SEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY-IEKIKSTGATYMAASGL 361
N LR+L+EII FD++L + +Y IEKIK G TYM A GL
Sbjct: 802 ----------NADTAGLRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGL 847
Score = 47.2 bits (107), Expect = 0.002
Identities = 20/51 (39%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V AG+IG K Q+DIW V++ +R++S+GL + V+Q +L
Sbjct: 361 GVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSML 411
>UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 87.0 bits (206), Expect = 2e-15
Identities = 74/275 (26%), Positives = 132/275 (48%), Gaps = 51/275 (18%)
Query: 241 LQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMF 300
L ++++ E +A + KLL ILP+ + +K+I F+ + H V F
Sbjct: 1324 LDETKKRKAAETAKAKSEKLLYQILPKDIVLRLNRGEKDIS-FN---INHSS-----VFF 1374
Query: 301 ASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASG 360
I FS++ L + E ++ L+ + +FD+I+ + P + KIK G YMAASG
Sbjct: 1375 IDIVKFSQYSSHLSPS----EIMQNLSLVFNNFDKIVVQFPL--VNKIKLIGDVYMAASG 1428
Query: 361 LTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCT 420
+ + QD H + L+ + ++ +N T +++
Sbjct: 1429 IFH--QDNSKEEHAESAVKCCLKCLKSMEDIN--------------------TKLNSSLE 1466
Query: 421 LRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQ 480
LR+ + GG LI GV+GA KP +DI G+ +NVA+R+ S+ + +Q
Sbjct: 1467 LRIGINSGGPLI--------------GGVLGADKPTFDIIGDPINVAARLQSSDIPGRVQ 1512
Query: 481 VTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
++Q + +++ + + + RG V +KGKGN +TYF+
Sbjct: 1513 ISQSIKELIKSNDFTIEERGEVFLKGKGNQITYFI 1547
>UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP04501p
- Drosophila melanogaster (Fruit fly)
Length = 710
Score = 85.8 bits (203), Expect = 4e-15
Identities = 38/82 (46%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARG 493
++ G++ GPVVAG++G + P+Y ++G+ VN ASRM+STG I +T+E++D L G
Sbjct: 588 QIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGG 647
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
++ RG +DVKGKG M TY+L
Sbjct: 648 FRTEHRGLIDVKGKGLMSTYWL 669
Score = 39.1 bits (87), Expect = 0.42
Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 20/147 (13%)
Query: 238 IWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC 297
++ L +++ ++++ + + LL +LP VA K Q A ELY ++V
Sbjct: 444 LYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL----KQTQQVPA-ELY----EAVT 494
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
+ F+ I F+E + +E + LN I FDE + E + + K+++ G +YM
Sbjct: 495 IYFSDIVGFTEIAADCTP----LEVVTFLNSIYRVFDERI--ECYD-VYKVETIGDSYMV 547
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRL 384
ASGL G +H++ +A AL L
Sbjct: 548 ASGLPVKN----GNKHISEIATMALDL 570
>UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theileria
parva|Rep: Cation-transporting ATPase - Theileria parva
Length = 2664
Score = 85.4 bits (202), Expect = 5e-15
Identities = 68/244 (27%), Positives = 116/244 (47%), Gaps = 17/244 (6%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E+ ++V V+FA + NF E +E + + +L+ + FD E F I KI++
Sbjct: 1695 ERHENVTVIFADVYNFQELIATIEPHR----LVEILDTLFLSFDRCSKE--FNAI-KIET 1747
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADY-ALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
TY+ + GL S+ +T D+ R ++ + S I I + +
Sbjct: 1748 VSETYLTSMGLNTSSTSQTKSLGMTDGHDHDQSRNKKSGSSLGRRSRRSKDIAIDTAVNK 1807
Query: 410 SDATASSANCTLRVRVEPGGALIVRR--------VPAGINIGPVVAGVIGARKPQYDIWG 461
DA +A+ +L + + + V GIN G V++G++G++KPQY ++G
Sbjct: 1808 LDAYVQAASSSLDMSIAMLQVATTIKLNTNESIGVKIGINSGYVISGLVGSKKPQYALFG 1867
Query: 462 NAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLE-GVGD 520
+ VN ASRM TG + I +++ Y+++ + VKGKG M TY LE +G
Sbjct: 1868 DTVNTASRMKMTGEVGRIHISESTYELVKGDKTLEFINREIAVKGKGVMNTYLLEKALGT 1927
Query: 521 SIPD 524
S P+
Sbjct: 1928 SYPN 1931
Score = 44.0 bits (99), Expect = 0.015
Identities = 17/52 (32%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G + GVIG+ + +YD+WG V A+ ++S G+ + V+++ DI++
Sbjct: 2562 GLHYGSCIGGVIGSGRLRYDVWGTDVYTANMIESNGVPGEVCVSEKFRDIIT 2613
>UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subunit
beta-2 (EC 4.6.1.2) (GCS-beta-2).; n=2; Gallus
gallus|Rep: Guanylate cyclase soluble subunit beta-2 (EC
4.6.1.2) (GCS-beta-2). - Gallus gallus
Length = 659
Score = 83.4 bits (197), Expect = 2e-14
Identities = 37/96 (38%), Positives = 61/96 (63%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ GPV+AGV+G + P+Y ++G+ VN+ASRM+S G+ I ++ Y L + +
Sbjct: 564 QIRVGIHTGPVLAGVVGEKMPRYCLFGDTVNIASRMESHGVPSKIHLSSSAYQCLKYKNF 623
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNP 530
++ RG ++VKGKG M TYFL + ++I P
Sbjct: 624 EMTERGEIEVKGKGKMHTYFLVRNKTACENEIMGRP 659
>UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|Rep:
Cya1625 - Mycobacterium smegmatis
Length = 369
Score = 83.4 bits (197), Expect = 2e-14
Identities = 46/89 (51%), Positives = 60/89 (67%), Gaps = 3/89 (3%)
Query: 434 RRVPA--GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA 491
RRVP G+ GPVVAGV+GAR+ YD+WG+AVNVASRM+ST + IQV ++ +
Sbjct: 260 RRVPLRIGLAAGPVVAGVVGARRFFYDVWGDAVNVASRMESTDVEGRIQVPDDMC-LRLR 318
Query: 492 RGYKLRCRGTVDVKGKGNMVTYFLEGVGD 520
+ L RG V+VKGKG M T++L G D
Sbjct: 319 HAFVLEERGEVEVKGKGVMRTWYLVGRRD 347
Score = 44.0 bits (99), Expect = 0.015
Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 22/174 (12%)
Query: 238 IWK-LQANEEKED-MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDS 295
+W L+ ED ME + KLLANILP +A + A+ + ++ D
Sbjct: 119 VWSALREIARAEDAMEAEYQRSEKLLANILPATIATRL--------KDPARTIIADRYDD 170
Query: 296 VCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATY 355
++FA I Y + + +R L+ + D D ++ + +EK+K++G +Y
Sbjct: 171 ASILFADIAG----YTKRASETAPCDLVRFLDTLYTDLDALVEQH---CLEKVKTSGDSY 223
Query: 356 MAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
M G+ D H A+A AL + + + + +RIG + P
Sbjct: 224 MVVGGIPEPRTD-----HAEALAALALDMAAAVADLTDPEGRRVPLRIGLAAGP 272
>UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2;
Culicidae|Rep: Soluble guanylate cyclase gcy - Aedes
aegypti (Yellowfever mosquito)
Length = 1025
Score = 83.4 bits (197), Expect = 2e-14
Identities = 45/130 (34%), Positives = 70/130 (53%), Gaps = 1/130 (0%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G++ G VVAG++G + P+Y ++G++VN ASRM+ST I ++Q + L + Y
Sbjct: 516 RIRVGVHSGAVVAGIVGLKMPRYCLFGDSVNTASRMESTSQAMKIHISQSTRNFLPS-NY 574
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAVPPRPEHRPLDTLSE 554
+ RG +DVKGKG M TY+L+ + P + + I S E + + T S
Sbjct: 575 HVSERGEIDVKGKGTMKTYWLDHKENRPPLQLLSEEIRQPSIEYIESSKDRRVSISTYSV 634
Query: 555 AHTDEDGGPS 564
H GG S
Sbjct: 635 PHKQSSGGLS 644
>UniRef50_A0MJN0 Cluster: Guanylate cyclase beta; n=11; Plasmodium
(Vinckeia)|Rep: Guanylate cyclase beta - Plasmodium
berghei
Length = 2952
Score = 83.4 bits (197), Expect = 2e-14
Identities = 78/282 (27%), Positives = 129/282 (45%), Gaps = 26/282 (9%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDA-QELYHEQCDSVCVMFASIPNFSEFYVELEGNN 317
++L +LP + ++ L SD D + + E + V+F I +F LE +
Sbjct: 1502 EILHTMLPSFLVEYLLVSDPKADGIMVGKNISGEDRGIISVIFCDIDDFQTMVSTLEPHT 1561
Query: 318 EGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YRHVTA 376
++ L+ + FD+ + + F I KI++ +Y+AASGL+ + V ++ T
Sbjct: 1562 ----LVQTLDNLYLYFDKCI--KYFNCI-KIETVFESYLAASGLSEKKNNCVHKIKYDTK 1614
Query: 377 MA-DYALRLREQLQYVNEHSFNCF-RIRIGKSCSPSDATASSANCTLRVRVEPGGALIVR 434
A A+ Y++ + + S P ++ N +LR+
Sbjct: 1615 CAIKMAIAQLSAKYYISYKVLDTLSNNKDSNSIFPIESKYIYKNISLRI----------- 1663
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
GI+ G ++GVIG+ KPQY ++G+ VN ASRM ST L DHI V+ + Y L
Sbjct: 1664 ----GIHTGKAISGVIGSVKPQYSLFGDTVNTASRMKSTSLKDHIHVSYDTYKYLKDDKT 1719
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSS 536
+ ++ +KGKG M TY L + D+ D STSS
Sbjct: 1720 LVWKERSIFIKGKGEMKTYLLVDILDNSKKDHTKALEESTSS 1761
Score = 38.3 bits (85), Expect = 0.73
Identities = 15/46 (32%), Positives = 30/46 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
G++ G V G+IG+ + +YD+WG V +A+ ++S G+ I +++
Sbjct: 2895 GLHYGSCVGGIIGSVRIRYDMWGLDVLIANHIESNGIPGEIVCSEQ 2940
>UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl
cyclase-G; n=6; Euteleostomi|Rep: PREDICTED: similar to
guanylyl cyclase-G - Monodelphis domestica
Length = 1111
Score = 83.0 bits (196), Expect = 3e-14
Identities = 50/110 (45%), Positives = 68/110 (61%), Gaps = 8/110 (7%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
G++ GPVVAGV+G P+Y ++G+ VN+ASRM+S L I V+Q L S GY L+
Sbjct: 974 GLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESNSLPLRIHVSQTTASALRSVGGYVLQ 1033
Query: 498 CRGTVDVKGKGNMVTYFLEG-VG--DSIPDDIYNNPIPSTSSEGAVPPRP 544
RGT+ VKGKG TY+L+G VG S+P+ + N S E PP+P
Sbjct: 1034 ERGTIKVKGKGEQTTYWLKGKVGFAMSLPEFMEEN----ESQEPLQPPQP 1079
Score = 35.9 bits (79), Expect = 3.9
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 13/121 (10%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
EQ DSV + F+ I F++ L + ++ + LLN++ + FD I+ + K+++
Sbjct: 870 EQFDSVTIFFSDIVGFTK----LCSLSTPLQVVGLLNDLYSLFDNIIKTYD---VYKVET 922
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQY--VNEHSFNCFRIRIGKSCS 408
G YM ASGL G +HV +A +L + + + ++RIG
Sbjct: 923 IGDAYMVASGLPLRN----GIQHVEEIATMSLHFLSVVVHFKIGHKPEEKLKLRIGLHTG 978
Query: 409 P 409
P
Sbjct: 979 P 979
>UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 696
Score = 83.0 bits (196), Expect = 3e-14
Identities = 82/304 (26%), Positives = 133/304 (43%), Gaps = 53/304 (17%)
Query: 242 QANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFA 301
Q + +E + +LL ILP + Q + I F +S ++F
Sbjct: 445 QIERQMRQVEEAKKSAERLLNQILPPMIVQKMNAGETEIS-FTV--------NSATIIFI 495
Query: 302 SIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
I FS++ L + ++ L I +DE++ + F + KIK G YMAA+GL
Sbjct: 496 DIQKFSDYAATLTAR----QIMQNLGRIFNYYDELVPK--FPTLIKIKLIGDVYMAAAGL 549
Query: 362 TNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTL 421
N D+ H T M ++A+ L+ NE A+ ++
Sbjct: 550 FN--PDVSPDVHATEMINFAIGCLHGLEEANE--------------------ILEASLSV 587
Query: 422 RVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
R+ + GG +I AG+ +G KP +DI G+ +NVASR+ ST + + IQ+
Sbjct: 588 RIGINTGGPII-----AGV---------LGIDKPLFDIIGDPINVASRLQSTDIPNMIQI 633
Query: 482 TQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAVP 541
+Q YD++ +G+ + RG + +KGKG + Y + I IPS S GA+P
Sbjct: 634 SQATYDLIKDKGFNVAERGKIFLKGKGEQMAYII--TPPERQRVISAQTIPSQLSVGALP 691
Query: 542 PRPE 545
E
Sbjct: 692 TAEE 695
>UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=5; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1681
Score = 83.0 bits (196), Expect = 3e-14
Identities = 85/322 (26%), Positives = 143/322 (44%), Gaps = 57/322 (17%)
Query: 200 RCGLDWNQQWTNI---AIALGATVALLLHSQQTESTYRLDFIWKLQANE--EKEDMEHLQ 254
+CGL + Q + + + LL S + + K Q E +KE +E +
Sbjct: 1401 QCGLVFESQLEGVRDDGVKVPLKATLLGFSSNHRNADFFAVMCKDQTEEMRQKEAVEVAK 1460
Query: 255 AYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELE 314
+ LL ILP + + +K+I S V+F I FS + L
Sbjct: 1461 KKSDDLLLKILPPDIIRRINKGEKDITMV---------VPSASVIFIDICQFSTYMATLS 1511
Query: 315 GNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHV 374
+C+ LN + +D+ILA+ P I KIK G YMAA+GL + D H
Sbjct: 1512 AQ----QCMSNLNAVFTAYDKILADLPL--ITKIKLIGDDYMAAAGL--FSPDEPPKSHA 1563
Query: 375 TAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVR 434
+ LR+ + ++ +NE +A+ +R+ V GG +I
Sbjct: 1564 IQTITFGLRVLDAIEELNEQ--------------------LNASLMVRIGVNSGGPII-- 1601
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG- 493
AG+ +G KP +DI G+ +NVA+R+ ST + ++Q+++ Y+I++ G
Sbjct: 1602 ---AGV---------LGTDKPLFDIIGDTINVAARLQSTDIPGNVQISKGTYEIVAGEGK 1649
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
+ + RG + +KGKGN +TY +
Sbjct: 1650 FHIEERGEIYLKGKGNQMTYLV 1671
>UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 1 beta -
Limax marginatus
Length = 444
Score = 82.6 bits (195), Expect = 3e-14
Identities = 38/83 (45%), Positives = 55/83 (66%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ G++ GPVVAGV+G + P+Y ++G+ VN ASRM+S G I ++ Y L + GY
Sbjct: 151 QIRVGVHTGPVVAGVVGVKMPRYCLFGDTVNTASRMESHGAPGRIHMSPTAYRALCSSGY 210
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
+ RG ++VKGKG M TYFL G
Sbjct: 211 VFKQRGQMEVKGKGVMSTYFLCG 233
>UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theileria
annulata|Rep: Cation-transporting ATPase - Theileria
annulata
Length = 2559
Score = 82.6 bits (195), Expect = 3e-14
Identities = 66/250 (26%), Positives = 119/250 (47%), Gaps = 18/250 (7%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E+ ++V V+FA + NF E +E + + +L+ + FD E F I KI++
Sbjct: 1661 ERHENVTVIFADVYNFQELIATIEPHR----LVEILDTLFLSFDRCSKE--FNAI-KIET 1713
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADY--ALRLREQLQYVNEHSFNCFRIRIGKSCS 408
TY+ + GL S +T+ + + ++ + S I I +
Sbjct: 1714 VSETYLTSMGLNTSASSQTNSLGLTSESSENGQSKTKKSRSTLGRKSRRSKDIAIDTIIN 1773
Query: 409 PSDATASSANCTLRVRV---EPGGALIVRR-----VPAGINIGPVVAGVIGARKPQYDIW 460
D+ +A+ +L + + + + + V GIN G V++G++G++KPQY ++
Sbjct: 1774 RFDSYVQAASSSLDMSIAMLQVATTIKLNNNESIGVKIGINSGYVISGLVGSKKPQYALF 1833
Query: 461 GNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLE-GVG 519
G+ VN ASRM TG + I +++ Y+++ ++VKGKG M TY LE +G
Sbjct: 1834 GDTVNTASRMKMTGEVGKIHISESTYELVKNDKTLEFINREIEVKGKGVMNTYLLEKALG 1893
Query: 520 DSIPDDIYNN 529
S P+ +N
Sbjct: 1894 TSYPNFTNSN 1903
Score = 45.2 bits (102), Expect = 0.006
Identities = 18/52 (34%), Positives = 34/52 (65%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G + GVIG+ + +YD+WG V A+ ++S G+ + V+++ DI+S
Sbjct: 2457 GLHYGSCIGGVIGSGRLRYDVWGTDVYTANMIESNGVPGEVCVSEKFRDIIS 2508
>UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep:
Guanylate cyclase - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 1176
Score = 82.2 bits (194), Expect = 5e-14
Identities = 45/107 (42%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA--R 492
++ G++ GPVVAGV+G + P+Y ++G+ VN ASRM+STGL I V Q D+L++
Sbjct: 1047 KIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKL 1106
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG-VGDSIPDDIYNNPIPSTSSEG 538
GYK+ RG ++KGKG T++L G G P I + P S+ G
Sbjct: 1107 GYKIDTRGRTELKGKGVEETFWLVGRDGFDKPLPIPPDLTPGASNHG 1153
Score = 40.3 bits (90), Expect = 0.18
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 20/138 (14%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + LLA +LP+ VA L + K + E V + F+ I
Sbjct: 910 ERTEELEVERQKTDALLAQMLPKSVALA-LKTGKPVKP--------EHFAEVTLYFSDIV 960
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+A + K+++ G YM ASG+ N
Sbjct: 961 GFTT----ISALSEPIEVVDLLNDLYTHFDGIIA---IHDVYKVETIGDAYMVASGVPNR 1013
Query: 365 TQDLVGYRHVTAMADYAL 382
G RH MA+ +L
Sbjct: 1014 N----GTRHAAEMANMSL 1027
>UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-2;
n=32; Euteleostomi|Rep: Guanylate cyclase soluble
subunit beta-2 - Homo sapiens (Human)
Length = 617
Score = 82.2 bits (194), Expect = 5e-14
Identities = 47/126 (37%), Positives = 72/126 (57%), Gaps = 15/126 (11%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GPV+A V+G + P+Y ++G+ VN ASRM+S GL + + ++ Y L +G+K+
Sbjct: 487 GIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQGFKIIE 546
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDDIYNN--------------PIPSTSSEGAVPPR- 543
RG ++VKGKG M TYFL ++ D+I +P+T +G+V P
Sbjct: 547 RGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQGSVQPSC 606
Query: 544 PEHRPL 549
PEH L
Sbjct: 607 PEHSSL 612
>UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC
7120|Rep: Adenylate cyclase - Anabaena sp. (strain PCC
7120)
Length = 472
Score = 81.8 bits (193), Expect = 6e-14
Identities = 39/83 (46%), Positives = 56/83 (67%), Gaps = 1/83 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GIN GPVVAGVIG +K YD+WG+ VN+ASRM+S G + I V+ +++L +
Sbjct: 384 KIRIGINSGPVVAGVIGIKKFIYDLWGDTVNIASRMESHGTPNRIHVSAASHELLK-DSF 442
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
RG +KGKG+M TY+L+G
Sbjct: 443 LFEDRGVTAIKGKGDMQTYWLKG 465
Score = 62.1 bits (144), Expect = 5e-08
Identities = 51/156 (32%), Positives = 74/156 (47%), Gaps = 14/156 (8%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
QA + KLL NILP+ +A+ S + +Q + + VMFA I F++ L
Sbjct: 252 QAQSEKLLLNILPQAIAERLKQSQPSPQT--SQMMIADGFSDATVMFADIVGFTD----L 305
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
G + LLN+I + FD +LAE +EKIK+ G YM GL N D H
Sbjct: 306 SGRIPPQRLVDLLNQIFSRFD-LLAES--YNLEKIKTIGDAYMVVGGLPNPRPD-----H 357
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
A+A L + + + N + F+IRIG + P
Sbjct: 358 AIAIAHMGLDILDAIAQFNLDTGEQFKIRIGINSGP 393
>UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate
cyclase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 699
Score = 81.4 bits (192), Expect = 8e-14
Identities = 36/83 (43%), Positives = 58/83 (69%), Gaps = 1/83 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS-ARGY 494
+ GI+ GPVVA V+G + P+Y ++G+ VN+ASRM +TG+ +Q++ E + L+ GY
Sbjct: 561 IRVGIHSGPVVAAVVGLKMPRYCLFGDTVNIASRMQTTGVPGRVQISYETFAALNDLGGY 620
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
K+ RG +++KGKG + TY+L G
Sbjct: 621 KVVKRGEIEIKGKGLLTTYWLNG 643
>UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulator;
n=3; Bacteria|Rep: Two-component hybrid sensor and
regulator - Bradyrhizobium japonicum
Length = 527
Score = 81.4 bits (192), Expect = 8e-14
Identities = 38/84 (45%), Positives = 59/84 (70%), Gaps = 1/84 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ GPVVAG+IGA + YD+WG+ VNVASR+++ L + I V++++ L R +
Sbjct: 445 QIRIGIHSGPVVAGIIGAHRFIYDVWGDTVNVASRLEAYSLPNRIHVSRDIARHLVGR-F 503
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGV 518
L RG++DVKGKG + T+FL +
Sbjct: 504 ALEPRGSIDVKGKGKLETFFLSRI 527
Score = 45.2 bits (102), Expect = 0.006
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 12/119 (10%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
++ + V V+FA + F+E + + LN + ++FD + E +EKIK+
Sbjct: 348 DRFEGVSVLFADLVGFTEHSSRVTP----AAMVEYLNRLFSEFDALARELG---VEKIKT 400
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
G YMA +GL + D + A+A AL + ++L VN H +IRIG P
Sbjct: 401 IGDAYMAVAGLPDPNPDA-----IAAIAKMALGMIDRLGRVNSHFGWPLQIRIGIHSGP 454
>UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 574
Score = 81.4 bits (192), Expect = 8e-14
Identities = 37/83 (44%), Positives = 57/83 (68%), Gaps = 1/83 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGY 494
+ G+N GP VAGV+G P+Y ++G+ +N ASRM+STG I +++ +IL G+
Sbjct: 461 IRVGVNTGPCVAGVVGTTMPRYCLFGDTINTASRMESTGEPMKIHLSENTKEILDKLGGF 520
Query: 495 KLRCRGTVDVKGKGNMVTYFLEG 517
K++ RGT++VKGKG M T++L G
Sbjct: 521 KIKRRGTIEVKGKGTMETFWLVG 543
>UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6;
Murinae|Rep: Guanylate cyclase 2G precursor - Mus
musculus (Mouse)
Length = 1100
Score = 81.4 bits (192), Expect = 8e-14
Identities = 39/80 (48%), Positives = 57/80 (71%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYD-ILSARGYKLR 497
G++ GPVVAGV+G P+Y ++G+ VN+ASRM+S+ L I V+Q +L+A GY L+
Sbjct: 999 GLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQ 1058
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RGT+ VKGKG T++L+G
Sbjct: 1059 KRGTISVKGKGEQTTFWLKG 1078
Score = 37.1 bits (82), Expect = 1.7
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 20/126 (15%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
KLL+ +LP V + L + K+++ E +SV + F+ I F++ L +
Sbjct: 872 KLLSTMLPSFVGEQ-LIAGKSVEP--------EHFESVTIFFSDIVGFTK----LCSLSS 918
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
++ ++LLN++ + FD + + K+++ G YM ASGL G +H +A
Sbjct: 919 PLQVVKLLNDLYSLFDHTIQSHD---VYKVETIGDAYMVASGLPIRN----GAQHADEIA 971
Query: 379 DYALRL 384
AL L
Sbjct: 972 TMALHL 977
>UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1;
Ralstonia eutropha H16|Rep: Putative regulatory protein
- Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428
/ Stanier 337)(Cupriavidus necator (strain ATCC 17699 /
H16 / DSM 428 / Stanier337))
Length = 412
Score = 81.0 bits (191), Expect = 1e-13
Identities = 40/84 (47%), Positives = 55/84 (65%), Gaps = 1/84 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G VVAGVIG RK YD+WG AVN+ASRM+S G+ +QVT +L ++
Sbjct: 328 GINSGAVVAGVIGKRKFIYDLWGAAVNIASRMESHGVAGRVQVTDATRRLL-GESFQFEE 386
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSI 522
RG+++ KG G + T+FL G D++
Sbjct: 387 RGSIEAKGIGALHTWFLTGRNDAV 410
Score = 64.9 bits (151), Expect = 7e-09
Identities = 55/194 (28%), Positives = 93/194 (47%), Gaps = 13/194 (6%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
NI A AL L +++ ++++ L + + + + Q + +LL N+LP +A
Sbjct: 148 NITEKKRAEAALALKNEELQASWELIRRQRDELQSLYDRILAEQKLSERLLLNLLPYPIA 207
Query: 271 QHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
+ L + ++ EL + V V+FA I F+ F + + + +LNEI
Sbjct: 208 ER-LKARPDLIASGVPELIADSFPEVTVLFADIVAFTRFSAGMSPE----QLVAILNEIF 262
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQY 390
+FD I AE + +EKIK+ G YMAA+GL D H A AL + + L +
Sbjct: 263 TEFDTI-AE--VRGLEKIKTIGDAYMAAAGLPEPAPD-----HAVRAAHMALNMSDALMH 314
Query: 391 VNEHSFNCFRIRIG 404
N+H+ ++RIG
Sbjct: 315 FNQHTGFNLQMRIG 328
>UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000003998 - Anopheles gambiae
str. PEST
Length = 649
Score = 81.0 bits (191), Expect = 1e-13
Identities = 39/82 (47%), Positives = 55/82 (67%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G + GP+VAG++G + P+Y ++G+ VN ASRM+S+G D IQV+ L GY
Sbjct: 562 VKIGFHSGPIVAGIVGLKVPRYCLFGDTVNTASRMESSGETDCIQVSGYTAQKLKKLGYV 621
Query: 496 LRCRGTVDVKGKGNMVTYFLEG 517
L RG V VKGKG+M T++L+G
Sbjct: 622 LAYRGKVAVKGKGDMETFWLQG 643
>UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A;
n=1; Microscilla marina ATCC 23134|Rep: Atrial
natriuretic peptide receptor A - Microscilla marina ATCC
23134
Length = 562
Score = 80.6 bits (190), Expect = 1e-13
Identities = 35/80 (43%), Positives = 54/80 (67%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GP++AGVIG +K YD+WG+ VN ASRM+S G+++ I V+Q Y+++ ++
Sbjct: 455 GINTGPLIAGVIGTKKFAYDVWGDTVNTASRMESNGVVNEISVSQVTYELVK-DFFECEY 513
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
G V KGKG + Y ++G+
Sbjct: 514 HGRVQAKGKGEIDMYLVKGI 533
Score = 37.9 bits (84), Expect = 0.96
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
KLL NILP VA+ + K+ D VMF F++ + +
Sbjct: 327 KLLLNILPSDVAEELKINGKS---------QVRNYDMATVMFTDFKGFTK----IASFTD 373
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
E ++ L+ A FD+I+ E +EKIK+ G YM G+ N +
Sbjct: 374 PAEIVKNLDTCFAAFDQIIEEYN---LEKIKTIGDAYMCVGGIPNENK 418
>UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1146
Score = 80.6 bits (190), Expect = 1e-13
Identities = 42/87 (48%), Positives = 56/87 (64%), Gaps = 2/87 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--ARGYKL 496
GIN G VVAGV+G P+Y ++G+AVN ASRM+S G I V+ E +L+ G++
Sbjct: 1038 GINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRT 1097
Query: 497 RCRGTVDVKGKGNMVTYFLEGVGDSIP 523
RG V +KGKG M TY+L G DS+P
Sbjct: 1098 EERGEVIIKGKGVMNTYWLLGENDSVP 1124
>UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to
ENSANGP00000011644; n=3; Euteleostomi|Rep: PREDICTED:
similar to ENSANGP00000011644 - Danio rerio
Length = 584
Score = 80.2 bits (189), Expect = 2e-13
Identities = 39/81 (48%), Positives = 54/81 (66%), Gaps = 1/81 (1%)
Query: 438 AGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY-DILSARGYKL 496
AGI+ GP VAGV+G + P+Y ++G+ VN ASRM+ST L I + Y ++ Y+L
Sbjct: 423 AGIHTGPCVAGVVGYKMPRYCLFGDTVNTASRMESTSLPQKIHASSATYLALMKDNAYEL 482
Query: 497 RCRGTVDVKGKGNMVTYFLEG 517
+ RG V+VKGKG M TY+L G
Sbjct: 483 QLRGEVEVKGKGKMDTYWLIG 503
>UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1;
Chlamydomonas reinhardtii|Rep: Soluble guanylyl cyclase
beta - Chlamydomonas reinhardtii
Length = 991
Score = 80.2 bits (189), Expect = 2e-13
Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 7/150 (4%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARG 493
R+ G++ GPVVAGV+G + P++ ++G+ VN ASRM+S G I +++ Y L S
Sbjct: 569 RIRVGMHSGPVVAGVVGRKMPRFCLFGDTVNTASRMESHGEAGQIHISEACYCCLRSKER 628
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPS-----TSSEGAVPPRPEHRP 548
+++R RG + VKGKG M TY L + + IP D P+P + P PE P
Sbjct: 629 FEIRERGNITVKGKGTMRTYLLSPL-ERIPCDSLFAPLPQLHVTCNLTSPDQPMGPESMP 687
Query: 549 LDTLSEAHTDEDGGPSPRASIPMVNTRKRL 578
L + SP P + R+ +
Sbjct: 688 ASCLECLLQECRSSVSPSGGYPAPSPRRAI 717
Score = 46.8 bits (106), Expect = 0.002
Identities = 44/150 (29%), Positives = 67/150 (44%), Gaps = 20/150 (13%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL +LP VA C KN ++ AQE H + V+F+ I F+E + +
Sbjct: 449 LLYQMLPPEVAS---CL-KNEERAPAQE--HPEAT---VLFSDIVGFTE----IASRSSP 495
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+E LL+E+ FD + E P Y K+++ G YM +T D H + +
Sbjct: 496 LEVCSLLDELYQRFDAAIEEYPQLY--KVETIGDAYMVVCNVTVPCDD-----HADVLLE 548
Query: 380 YALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
+ALR+ E+ V RIR+G P
Sbjct: 549 FALRMHEEASRVASSLGEPVRIRVGMHSGP 578
>UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1457
Score = 80.2 bits (189), Expect = 2e-13
Identities = 36/95 (37%), Positives = 62/95 (65%), Gaps = 6/95 (6%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
++ GIN G PV+AGV+G KP +DI G+ +NVA+R+ ST ++HI ++Q +D++
Sbjct: 1359 QIRIGINTGGPVIAGVLGTDKPAFDIIGDPINVAARLQSTDEVNHIHISQATFDLIRGSN 1418
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYN 528
Y++ RG +KGKG +TY++ ++P ++N
Sbjct: 1419 YEVTQRGETFLKGKGKQMTYYV-----TVPPTVFN 1448
>UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 418
Score = 79.8 bits (188), Expect = 2e-13
Identities = 40/83 (48%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G + GPV AGVIG K YDIWG+ VN+ASRM+S+G I V++E Y +LS +
Sbjct: 319 VRIGFHTGPVAAGVIGKNKFSYDIWGDTVNIASRMESSGEPGKINVSEESYKLLSP-FFT 377
Query: 496 LRCRGTVDVKGKGNMVTYFLEGV 518
RG + K KG + YFLEG+
Sbjct: 378 FTSRGKIAAKNKGEISMYFLEGL 400
>UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 975
Score = 79.8 bits (188), Expect = 2e-13
Identities = 39/80 (48%), Positives = 54/80 (67%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR-GYKLR 497
G++ GP AGV+G P+Y ++G+ VN ASRM+STG I ++QE D L AR GY +
Sbjct: 501 GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIE 560
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG +D+KGKG M T++L G
Sbjct: 561 PRGLIDIKGKGMMNTFWLLG 580
>UniRef50_Q9GVB8 Cluster: Guanylyl cyclase enzyme; n=3;
Plasmodium|Rep: Guanylyl cyclase enzyme - Plasmodium
falciparum
Length = 3124
Score = 79.8 bits (188), Expect = 2e-13
Identities = 67/265 (25%), Positives = 122/265 (46%), Gaps = 23/265 (8%)
Query: 259 KLLANILPEHVAQHFLCSD-KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNN 317
++L +LP + ++ L SD KN + + E + V+F I +F L+ +
Sbjct: 1509 EILHTMLPNFLVEYLLISDPKNDGIMVGKNISGEDRGIISVIFCDIDDFQNMVSTLQPH- 1567
Query: 318 EGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAM 377
+ L+ + FD+ + + F I KI++ +Y+AASGL+ + + M
Sbjct: 1568 ---VLVETLDNLYLYFDKCI--KYFNCI-KIETVFESYLAASGLSEKKNNALD----KIM 1617
Query: 378 ADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVP 437
D ++ + ++ + +++ + ++T+ + ++
Sbjct: 1618 YDTKCAIKLAIAQLSAKYYISYKVLDTREHFSDNSTSYDKYINKNISLK----------- 1666
Query: 438 AGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR 497
GI+ G ++GVIG+ KPQY ++G+ VN ASRM ST L DHI V+ + Y L +
Sbjct: 1667 IGIHTGKAISGVIGSVKPQYALFGDTVNTASRMKSTSLPDHIHVSYDTYKYLKEDNTFIW 1726
Query: 498 CRGTVDVKGKGNMVTYFLEGVGDSI 522
V +KGKG M TY L + D +
Sbjct: 1727 KERKVFIKGKGKMKTYLLVDILDDV 1751
Score = 38.7 bits (86), Expect = 0.55
Identities = 15/46 (32%), Positives = 31/46 (67%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
G++ G V G+IG+ + +YD+WG V +A++++S G+ I +++
Sbjct: 3067 GLHYGSCVGGIIGSVRIRYDMWGLDVLIANKIESNGIPGEIICSEQ 3112
>UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 79.8 bits (188), Expect = 2e-13
Identities = 83/299 (27%), Positives = 129/299 (43%), Gaps = 51/299 (17%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL Q +TY + Q ++E E + + +LL ILP + +K+
Sbjct: 1321 LALASQGQGEINTYVFFIEDESQILHKQEQAELAKKKSEELLFQILPRDIVFKLNQGEKD 1380
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
I F S +MF I FS++ L + + L+ I FD+ L +
Sbjct: 1381 IT-FTVP--------SATIMFIDIVRFSDYAANLTPQ----QIMGNLSLIFDTFDKHLTD 1427
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
P I KIK G YM A+GL T D H M +A+ +++ +N
Sbjct: 1428 YPL--ITKIKLIGDVYMCAAGL--FTPDGQLQDHAQQMLRFAIDCLAEIENIN------- 1476
Query: 400 RIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDI 459
A + ++RV V GG LI G++G KP +DI
Sbjct: 1477 -------------VALESMLSVRVGVNTGGPLI--------------GGILGTDKPVFDI 1509
Query: 460 WGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGV 518
G+ +NVA+R+ ST + +Q+ Q VYD++ A + + RG V +KGKGN+ TY + V
Sbjct: 1510 IGDPINVAARLQSTDIPGKVQIPQSVYDLVHAMEFNIEKRGEVYLKGKGNVTTYLVSPV 1568
>UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to
ENSANGP00000014144; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000014144 - Nasonia
vitripennis
Length = 1648
Score = 79.4 bits (187), Expect = 3e-13
Identities = 39/89 (43%), Positives = 57/89 (64%), Gaps = 1/89 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG-Y 494
V G++ GPV AGV+G + P Y ++G+ VN ASRM+S+GL I V++ DIL G +
Sbjct: 1514 VRIGVHSGPVCAGVVGQKMPHYCLFGDTVNTASRMESSGLPLRIHVSRATKDILDKYGTF 1573
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGDSIP 523
L RG V++KGKG + T++L G + P
Sbjct: 1574 DLELRGDVELKGKGKVTTFWLTGCSEPDP 1602
Score = 35.5 bits (78), Expect = 5.1
Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 16/123 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E+ E + + + +LL +LP VA + + + EQ + V + F+ I
Sbjct: 1376 EKTEQLSLEKRRSEELLYQVLPRQVACQLMAGEM---------VQPEQFECVTIYFSDIV 1426
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ L + +E + LN++ + FD I+ F + K+++ G YM SGL
Sbjct: 1427 GFTA----LCAKSTPMEVVDFLNDLYSTFDRIIG---FYDVYKVETIGDAYMVVSGLPER 1479
Query: 365 TQD 367
D
Sbjct: 1480 NGD 1482
>UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1498
Score = 79.4 bits (187), Expect = 3e-13
Identities = 75/271 (27%), Positives = 127/271 (46%), Gaps = 50/271 (18%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
++++D E +A + KLL ILP+ + +K+I F + + F I
Sbjct: 1254 KKRKDAEIAKAKSEKLLYQILPKDIVVRLNRGEKDI-SFTIPK--------ATIFFVDIV 1304
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FS + L + E + L+ + + FD+I+ + P I KIK G YMAA+G+ +
Sbjct: 1305 KFSNYAAALSPS----EIMSNLSLVFSTFDKIVVKYP--TILKIKLIGDVYMAAAGIFSD 1358
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVR 424
Q + + A+ ++ +Q V E +++ SA +R+
Sbjct: 1359 PQ-----MNPSKPAEESVNCCLDIQKVMEQ----INVKL------------SAGLEVRIG 1397
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
V GG LI GV+G KP +DI G+ +NVASR+ ST + +Q++QE
Sbjct: 1398 VNTGGPLI--------------GGVLGTDKPTFDIIGDPINVASRLQSTDIPGKVQISQE 1443
Query: 485 VYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
++++ + + RG V +KGKGN TYF+
Sbjct: 1444 TKEMIAGSNFVIEERGEVYLKGKGNRTTYFV 1474
>UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1
precursor; n=5; Caenorhabditis|Rep: Guanylate cyclase
receptor-type gcy-1 precursor - Caenorhabditis elegans
Length = 1137
Score = 79.4 bits (187), Expect = 3e-13
Identities = 82/295 (27%), Positives = 132/295 (44%), Gaps = 61/295 (20%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL+ +LP+ VA+ Q + E DSV V F+ + F+ L
Sbjct: 870 LLSRMLPKQVAERLKAG---------QTVEPEGFDSVTVFFSDVVKFTI----LASKCSP 916
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+ + LLN++ ++FD I+ + + K++S G Y+ SGL GY H+ + D
Sbjct: 917 FQTVNLLNDLYSNFDTIIEQHG---VYKVESIGDGYLCVSGLPTRN----GYAHIKQIVD 969
Query: 380 YALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAG 439
+L+ E + SFN + P + N LR+ V G
Sbjct: 970 MSLKFMEYCK-----SFNIPHL-------PRE------NVELRIGVNSG----------- 1000
Query: 440 INIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA---RGYKL 496
P VAGV+G P+Y ++G+ VN ASRM+S G I +T + + +L+ Y+
Sbjct: 1001 ----PCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYET 1056
Query: 497 RCRGTVDVKGKGNMVTYFLEG-VGDSIPDD---IYNNPIPSTSSEGAVP-PRPEH 546
RG V +KGKG M T+++ G G+ P + I N P +++ +P P H
Sbjct: 1057 SSRGEVIIKGKGVMETFWVHGRFGEMEPTELRSISNRSTPPVTNDRWIPNPSSSH 1111
>UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whole
genome shotgun sequence; n=3; Euteleostomi|Rep:
Chromosome undetermined SCAF14699, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1292
Score = 78.6 bits (185), Expect = 6e-13
Identities = 48/102 (47%), Positives = 60/102 (58%), Gaps = 26/102 (25%)
Query: 287 ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEI---------- 336
ELY + + + VMFASIPNFS+FY E NN G+ECLR LNEII+DFD +
Sbjct: 978 ELYSQSYEEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSVSCRPPPAFTC 1037
Query: 337 ---------------LAEEP-FKYIEKIKSTGATYMAASGLT 362
L +EP F+ I KIK+ G+TYMAASG+T
Sbjct: 1038 ARVHGSVTCDLCSRQLLDEPQFRCITKIKTIGSTYMAASGVT 1079
Score = 72.5 bits (170), Expect = 4e-11
Identities = 32/43 (74%), Positives = 38/43 (88%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV
Sbjct: 1160 GLNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQV 1202
Score = 56.4 bits (130), Expect = 3e-06
Identities = 24/59 (40%), Positives = 38/59 (64%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDK 278
V+ S+ E R F+WK++ +E+KE + ++ +N L+ N+LPEHVA+HFL S K
Sbjct: 884 VSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKK 942
Score = 54.0 bits (124), Expect = 1e-05
Identities = 45/164 (27%), Positives = 72/164 (43%), Gaps = 3/164 (1%)
Query: 354 TYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDAT 413
T + S D ++H+ +AD+AL ++ L +N SFN F +RIG + A
Sbjct: 1110 TVVVLSSQKEERSDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLRIGLNKGGVLAG 1169
Query: 414 ASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDST 473
A + + R+ + +G + A P A V + +
Sbjct: 1170 VIGARKP-HYDIWGNTVNVASRMESTGVMGNIQVCPGCAFAPDTKTTTLA-GVCVGL-TA 1226
Query: 474 GLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
G+ QV +E Y IL G++ RG + VKGKG ++TYFL+G
Sbjct: 1227 GVCPLFQVVEECYSILKEYGFRFVRRGPIFVKGKGELLTYFLKG 1270
Score = 51.6 bits (118), Expect = 7e-05
Identities = 59/232 (25%), Positives = 94/232 (40%), Gaps = 43/232 (18%)
Query: 207 QQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILP 266
Q N+ I A ++ + +R F+ Q+ E K ++E +LL +ILP
Sbjct: 225 QLLANVVIYACAITVGIMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILP 284
Query: 267 EHVAQHFLC------SDKNIDQFDAQELY-HEQ---------------------CDSVCV 298
+H+A L S K + QF+ +Y HE C V +
Sbjct: 285 KHIADEMLQDMKKEPSQKEMQQFNTMYMYRHENVRYTHRAYADPHVRATERLCACGLVSI 344
Query: 299 MFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP-----FKYIE-KIKSTG 352
+FA I F++ L + E ++LLNE+ A FD++ A P KY + +IK G
Sbjct: 345 LFADIVGFTQ----LSSSCSAQELVKLLNELFARFDKLAAVSPDSRSHSKYHQLRIKILG 400
Query: 353 ATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
Y GL + +D H L + E + YV E + +R+G
Sbjct: 401 DCYYCICGLPDYRED-----HAACSIMMGLAMVEAISYVREKTQTDVDMRVG 447
Score = 46.8 bits (106), Expect = 0.002
Identities = 17/51 (33%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q + L
Sbjct: 447 GVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLECL 497
>UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep:
Guanylate cyclase - Manduca sexta (Tobacco hawkmoth)
(Tobacco hornworm)
Length = 1258
Score = 78.6 bits (185), Expect = 6e-13
Identities = 44/97 (45%), Positives = 60/97 (61%), Gaps = 4/97 (4%)
Query: 422 RVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
RVR P L +R G++ GP AGV+G P+Y ++G+ VN ASRM+STG IQ
Sbjct: 999 RVRHLPDTPLHLR---IGLHSGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQT 1055
Query: 482 TQEVYD-ILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
+ + +L+A GY+LR RG +KGKG M TY+L G
Sbjct: 1056 SAATAEKLLAAGGYRLRSRGLTQIKGKGAMHTYWLLG 1092
>UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 987
Score = 78.6 bits (185), Expect = 6e-13
Identities = 41/96 (42%), Positives = 61/96 (63%), Gaps = 4/96 (4%)
Query: 421 LRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQ 480
L +R PG + +R GI+ G VAGV+G + P+Y ++G+ VN ASRM+STG I
Sbjct: 895 LEIRHRPGEFIQIR---IGIHSGQCVAGVVGLKMPRYCLFGDTVNTASRMESTGDAMKIH 951
Query: 481 VTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFL 515
++ Y++L GY+ RG ++VKGKG+M TY+L
Sbjct: 952 ISSVTYNLLKKIGGYRFEERGVINVKGKGDMRTYWL 987
>UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1;
Manduca sexta|Rep: NO-insensitive guanylyl cyclase -
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Length = 500
Score = 78.6 bits (185), Expect = 6e-13
Identities = 47/121 (38%), Positives = 72/121 (59%), Gaps = 11/121 (9%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTG--LLDHIQ-VTQ 483
PG L++R G++ GP VAGV+G + P+Y ++G+ VN ASRM+S G L H+ T+
Sbjct: 254 PGERLLLR---IGMHTGPCVAGVVGLKMPRYCLFGDTVNTASRMESHGEALKIHVSPKTK 310
Query: 484 EVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAVPPR 543
EV D+ ++L CRG + +KGKG M TY+L +G+ +P +NP + + V
Sbjct: 311 EVLDLYDC--FELDCRGEITMKGKGKMTTYWL--LGEKVPQH-QDNPNEAIDTRNNVVNN 365
Query: 544 P 544
P
Sbjct: 366 P 366
Score = 41.1 bits (92), Expect = 0.10
Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 22/146 (15%)
Query: 241 LQANEEKEDMEHLQAYNR--KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCV 298
L+A E+ ++L+ + +LL +LP+ VA + Q + E D V +
Sbjct: 116 LEALVEERTSDYLEEKRKCEELLYQLLPKSVASQLIMG---------QPVMAETYDQVTI 166
Query: 299 MFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAA 358
F+ I F++ L + +E + LLN++ FD I+ E F + K+++ G YM
Sbjct: 167 YFSDIIGFTQ----LSAESTPLEVVDLLNDLYTSFDSII--ENFD-VYKVETIGDAYMVV 219
Query: 359 SGLTNSTQDLVGYRHVTAMADYALRL 384
SGL G RH +A +L L
Sbjct: 220 SGLPMRN----GNRHAAEIARMSLAL 241
>UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; cellular organisms|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1591
Score = 78.6 bits (185), Expect = 6e-13
Identities = 72/270 (26%), Positives = 121/270 (44%), Gaps = 51/270 (18%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+K+ E +A + KLL ILP V +K+I S ++F I
Sbjct: 1336 QKKQAEEAKAKSEKLLYQILPRDVVVQLNKGEKDISFV---------VPSATIIFIDINK 1386
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
FSE+ L + + LN A D+I A+ + ++KIK G YMAA+GL N+
Sbjct: 1387 FSEYSANLTPQ----DIMANLNHYFACIDKIAAK--YNMLQKIKLIGDIYMAAAGLFNT- 1439
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRV 425
D +H + L + + +N +++ AN +RV +
Sbjct: 1440 -DSPAEQHAEQTILFGLDVVATMDEIN--------LKL------------DANLQIRVGI 1478
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
GG +I AGV+G KP +DI G+ +NVA+R+ ST ++ + ++Q
Sbjct: 1479 NSGGPVI--------------AGVLGTDKPVFDIIGDPINVAARLQSTCEVNRVHISQAT 1524
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
+D++ + + RG +KGKG +TY++
Sbjct: 1525 FDLVKGSNFDVVQRGETFLKGKGKQITYYI 1554
>UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12;
Coelomata|Rep: Soluble guanylate cyclase 88E -
Drosophila melanogaster (Fruit fly)
Length = 947
Score = 78.6 bits (185), Expect = 6e-13
Identities = 36/89 (40%), Positives = 58/89 (65%), Gaps = 1/89 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G++ G VVAG++G + P+Y ++G+ VN ASRM+ST + + +++ +L Y
Sbjct: 513 RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST-KVLIGPNY 571
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGVGDSIP 523
K+ RG +DVKGKG M TY+LE + +P
Sbjct: 572 KIIERGEIDVKGKGTMGTYWLEERENRLP 600
Score = 35.1 bits (77), Expect = 6.8
Identities = 37/147 (25%), Positives = 66/147 (44%), Gaps = 20/147 (13%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
+LL ++P+ VA + ID E DSV ++F+ I F+E +
Sbjct: 390 ELLYQMIPKQVADRLRRGENPIDTC-------EMFDSVSILFSDIVTFTEICSRI----T 438
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
+E + +LN + + FD+ L E Y K+++ G YM +G + + H +
Sbjct: 439 PMEVVSMLNAMYSIFDK-LTERNSVY--KVETIGDAYMVVAGAPDKDAN-----HAERVC 490
Query: 379 DYALRLREQLQYVNEHSF-NCFRIRIG 404
D AL + + + + + S RIR+G
Sbjct: 491 DMALDMVDAITDLKDPSTGQHLRIRVG 517
>UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific;
n=3; Dictyostelium discoideum|Rep: Adenylate cyclase,
germination specific - Dictyostelium discoideum (Slime
mold)
Length = 858
Score = 78.6 bits (185), Expect = 6e-13
Identities = 40/85 (47%), Positives = 55/85 (64%), Gaps = 3/85 (3%)
Query: 435 RVPAGINIGPVVAGVI-GARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI-LSAR 492
+V GI+ GPV++GVI G KP +D+WG+ VNVASRM+STG+ I V+ VY +
Sbjct: 489 QVRVGIHCGPVISGVISGYAKPHFDVWGDTVNVASRMESTGIAGQIHVSDRVYQLGKEDF 548
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG 517
+ RC + VKGKG M T++L G
Sbjct: 549 NFSERC-DIIHVKGKGRMKTWYLMG 572
Score = 44.8 bits (101), Expect = 0.008
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 16/160 (10%)
Query: 254 QAYNRKLLANILPE--HVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYV 311
Q + L+A I+ E ++ L + ++ + +++ E+ ++ CV F I F+ F
Sbjct: 351 QRKQKSLIAKIMREKNNLINKILPLEVSVKLENGEDVVAERSNNACVFFLDIAGFTRF-- 408
Query: 312 ELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGY 371
+ + +++L +I D + A+ IEKIK+ G YMA G+ D+
Sbjct: 409 --SSIHSPEQVIQVLIKIFNSMDLLCAKHG---IEKIKTIGDAYMATCGIFPKCDDI--- 460
Query: 372 RHVT-AMADYALRLREQLQYVNEHSFNC-FRIRIGKSCSP 409
RH T M +A+ + E + E SF+ ++R+G C P
Sbjct: 461 RHNTYKMLGFAMDVLEFIP--KEMSFHLGLQVRVGIHCGP 498
>UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 650
Score = 77.8 bits (183), Expect = 1e-12
Identities = 39/92 (42%), Positives = 60/92 (65%), Gaps = 4/92 (4%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
PG + +R GI+ GPVVAG++G++ P+Y ++G VN+AS+M+S GL + IQ++ + +
Sbjct: 532 PGTKMTLR---IGIHTGPVVAGIVGSKMPRYCLFGETVNIASKMESNGLPNRIQISDDCH 588
Query: 487 DILS-ARGYKLRCRGTVDVKGKGNMVTYFLEG 517
IL GY + RG V + KG M TY+L G
Sbjct: 589 RILKITGGYTMVRRGEVLLTDKGTMTTYWLTG 620
>UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1;
Pseudoalteromonas atlantica T6c|Rep: Adenylate/guanylate
cyclase - Pseudoalteromonas atlantica (strain T6c /
BAA-1087)
Length = 407
Score = 77.4 bits (182), Expect = 1e-12
Identities = 40/79 (50%), Positives = 50/79 (63%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI G VVAGVIG K YD+WG AV +A+RM+S G D IQVTQ Y+ ++ Y
Sbjct: 327 GIGSGEVVAGVIGRSKFCYDLWGEAVTLAARMESHGRTDQIQVTQSTYE-MAKHKYCFEP 385
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V +KG G + TY+L G
Sbjct: 386 RGEVKIKGLGQIKTYWLLG 404
Score = 40.7 bits (91), Expect = 0.14
Identities = 39/145 (26%), Positives = 62/145 (42%), Gaps = 21/145 (14%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL NILP +AQ K + Q +Q D V + F + NFS L+
Sbjct: 204 LLLNILPRPIAQRL----KTV-----QGKIADQYDQVSICFLDLENFSLLVKTLKAQ--- 251
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+ LL+++ + FD + +EKIK+ G YMAA+G+ + + H
Sbjct: 252 -ALVDLLDDVFSQFDRLSEHHG---LEKIKTIGDGYMAAAGVPD-----INNAHAVQCCA 302
Query: 380 YALRLREQLQYVNEHSFNCFRIRIG 404
YAL +++ + +RIG
Sbjct: 303 YALAVKDAFSALQHKYHLTTGLRIG 327
>UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1119
Score = 77.4 bits (182), Expect = 1e-12
Identities = 37/84 (44%), Positives = 55/84 (65%), Gaps = 1/84 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARG 493
R+ G+N GP VAGV+G + P+Y ++G+ VN ASRM+S G+ I + +IL G
Sbjct: 934 RLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGG 993
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEG 517
Y++ RG V++KGKG +TYF+ G
Sbjct: 994 YEIEERGIVEMKGKGKQMTYFVRG 1017
Score = 43.2 bits (97), Expect = 0.026
Identities = 47/168 (27%), Positives = 78/168 (46%), Gaps = 24/168 (14%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHF-LCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
E E++E +A + LL +LPE VA L S+ + + F E C V F+
Sbjct: 797 ERNEELEGEKAKSEALLKMMLPEVVADSLKLGSNVSAESF-------ENCT---VFFSDC 846
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTN 363
P F VE+ ++ ++ ++ LN++ FD I+ + F + K+++ YM ASGL
Sbjct: 847 PGF----VEMSATSKPIDIVQFLNDLYTVFDRII--DQFD-VYKVETIADAYMVASGLPV 899
Query: 364 STQDLVGYRHVTAMADYALRLREQLQ-YVNEHSFN-CFRIRIGKSCSP 409
G H +A L L + ++ + H N R+RIG + P
Sbjct: 900 PN----GNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGP 943
>UniRef50_A2DBX9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=11; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1544
Score = 77.0 bits (181), Expect = 2e-12
Identities = 35/83 (42%), Positives = 56/83 (67%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ GIN G P+VAGVIG KP ++I G A+N+A M+S G+ + +++ VY+++ +
Sbjct: 1462 RIRVGINTGGPIVAGVIGTEKPTFEILGPAINIAHEMESHGIPMKVHISRSVYELIYGQN 1521
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ ++ RG +DVK KG M TY +E
Sbjct: 1522 FDIKERGEIDVK-KGKMFTYIVE 1543
Score = 45.6 bits (103), Expect = 0.005
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 17/145 (11%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
+LA+ILP + +KNI C S ++F + F+ + G+++
Sbjct: 1339 MLASILPPMLVVKVQAGEKNISF---------ACQSATILFLDVVEFTPWC----GSHDA 1385
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+R+LN + +FD I K + KIK G YMAA G+ + H + D
Sbjct: 1386 QYVMRMLNIMFKEFDVIT--NAHKTMTKIKCIGDCYMAAGGIFDEVNQ--PPVHAKEVVD 1441
Query: 380 YALRLREQLQYVNEHSFNCFRIRIG 404
+ ++ ++L ++E RIR+G
Sbjct: 1442 FGCKVIKKLLEIDEQENEKLRIRVG 1466
>UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium
falciparum|Rep: Guanylyl cyclase - Plasmodium falciparum
Length = 4226
Score = 76.6 bits (180), Expect = 2e-12
Identities = 34/84 (40%), Positives = 55/84 (65%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
RV GI+ G ++AGV+G++KPQY ++G+ VN ASRM +TG D+I +++ Y+++
Sbjct: 3234 RVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDDKT 3293
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGV 518
+ + ++KGKG M TY L V
Sbjct: 3294 LIYEKKETEIKGKGIMTTYLLTSV 3317
Score = 40.3 bits (90), Expect = 0.18
Identities = 18/51 (35%), Positives = 31/51 (60%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V GVIG+ + +YD+WG V + M+S G+ I V++ + + L
Sbjct: 4072 GLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLMESNGIPGKINVSETLKNFL 4122
>UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n=48;
Euteleostomi|Rep: Retinal guanylyl cyclase 2 precursor -
Homo sapiens (Human)
Length = 1108
Score = 76.6 bits (180), Expect = 2e-12
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 2/85 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--AR 492
R+ G++ GPVVAGV+G P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 978 RIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG 517
GY++ RG ++KGKG T++L G
Sbjct: 1038 GYEVELRGRTELKGKGTEETFWLIG 1062
Score = 40.7 bits (91), Expect = 0.14
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + KLL +LP VA+ L ++ E D V + F+ I
Sbjct: 841 ERTEELEIEKQKTEKLLTQMLPPSVAES-LKKGCTVEP--------EGFDLVTLYFSDIV 891
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 892 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPKR 944
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 945 N----GSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGP 987
>UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to
ENSANGP00000003998; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000003998 - Nasonia
vitripennis
Length = 643
Score = 76.2 bits (179), Expect = 3e-12
Identities = 43/117 (36%), Positives = 66/117 (56%), Gaps = 3/117 (2%)
Query: 421 LRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQ 480
+R V P G I R+ GI+ GP VAGV+G + P+Y +G+ VN ASRM +T L +
Sbjct: 516 VRSLVLPSGLEIQIRI--GIHSGPAVAGVVGIKVPRYCFFGDTVNTASRMQTTSLPGKVH 573
Query: 481 VTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSSE 537
++ +L Y + RG V VKGKGNM T++L + + D++ N S++ +
Sbjct: 574 ISPHTRALLPQDRYVIESRGIVSVKGKGNMETFWLRPKVE-LEDELDRNSASSSACQ 629
Score = 45.6 bits (103), Expect = 0.005
Identities = 41/154 (26%), Positives = 77/154 (50%), Gaps = 20/154 (12%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
+LL +++P+ VA +D ++ E S+ V+F + +F+ Y +EG
Sbjct: 407 ELLYSMIPQSVADRLRAGTSPLDTCESFE-------SISVLFCELCDFN--YSTIEG--- 454
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
++ + +N + + FD ++ + F + K+++ G YMAASG + T D H +A
Sbjct: 455 AMDIVSSMNAVYSCFDSLM--DKFN-VYKVETVGRVYMAASGAPDRTDD-----HAINVA 506
Query: 379 DYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDA 412
D +L+L Q++ + S +IRIG P+ A
Sbjct: 507 DVSLQLISQVRSLVLPSGLEIQIRIGIHSGPAVA 540
>UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1268
Score = 76.2 bits (179), Expect = 3e-12
Identities = 70/226 (30%), Positives = 110/226 (48%), Gaps = 45/226 (19%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E D V + F+ I F++ L + + + LLN++ FD+I++ + + K+++
Sbjct: 873 ESFDCVTIFFSDIVGFTK----LSSMSTPFQVVDLLNDLYTLFDDIIS---YYNVYKVET 925
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPS 410
G YM SGL + RH + AL L +++Q F+IR P
Sbjct: 926 IGDAYMLVSGLPIRNDN----RHAAEIGSTALHLIDEVQK--------FKIRH----RPD 969
Query: 411 DATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRM 470
D TL++RV GI+ GPVV GV+G P+Y ++G+ VN +SRM
Sbjct: 970 D--------TLKLRV-------------GIHSGPVVTGVVGLTMPRYCLFGDTVNTSSRM 1008
Query: 471 DSTGLLDHIQVTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFL 515
+S G I + E IL GY + RG V +KGKG+++TY+L
Sbjct: 1009 ESNGEALKIHCSAECKAILDEVGGYDVPERGIVAMKGKGSLLTYWL 1054
>UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1170
Score = 75.8 bits (178), Expect = 4e-12
Identities = 40/81 (49%), Positives = 52/81 (64%), Gaps = 2/81 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--ARGYKL 496
GIN G VVAGV+G P+Y ++G+AVN ASRM+S G I VT E +L+ G++
Sbjct: 1032 GINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRT 1091
Query: 497 RCRGTVDVKGKGNMVTYFLEG 517
RG V +KGKG M TY+L G
Sbjct: 1092 ESRGEVIIKGKGVMETYWLLG 1112
>UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 75.8 bits (178), Expect = 4e-12
Identities = 34/84 (40%), Positives = 54/84 (64%), Gaps = 1/84 (1%)
Query: 436 VPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
V G+N G P++ G++G KP +DI G+ +NVASR+ ST + +Q+ Q V+D++ +
Sbjct: 1464 VRIGVNTGGPLIGGILGTDKPVFDIIGDPINVASRLQSTDIPGKVQIPQSVFDLVHNLDF 1523
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGV 518
+ RG V +KGKGN+ TY + V
Sbjct: 1524 NIEKRGEVYLKGKGNVTTYLVSPV 1547
Score = 41.9 bits (94), Expect = 0.059
Identities = 47/186 (25%), Positives = 77/186 (41%), Gaps = 17/186 (9%)
Query: 219 TVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDK 278
T+ L + +TY + Q +++E E + + +LL ILP + +K
Sbjct: 1299 TILALSSKGEEINTYVFFISDESQILKKQEQAELAKKKSEELLFQILPRDIVFKLNQGEK 1358
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
+I F S +MF I FS++ L + + L+ I FD L
Sbjct: 1359 DIT-FTVP--------SATIMFIDIVRFSDYAANLTPQ----QIMGNLSLIFDTFDRHLT 1405
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+ P I KIK G YM A+GL T D H M +A+ ++++ +N +
Sbjct: 1406 DYPL--ITKIKLIGDVYMCAAGL--FTPDGQPQEHAQQMLHFAIDCLQEIENINVTLESM 1461
Query: 399 FRIRIG 404
+RIG
Sbjct: 1462 LAVRIG 1467
>UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=7; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 75.8 bits (178), Expect = 4e-12
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 51/273 (18%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+ + E +A + KLL ILP + +K+I F +S ++F I
Sbjct: 1334 QMKQAEEAKAKSEKLLYQILPRDIVVQLNRGEKDIT-FTV--------NSATIIFIDIVR 1384
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
FSE+ V L + ++ L+ A D+I ++ + + KIK G YMAA+GL N
Sbjct: 1385 FSEYTVNLSPQ----DIMQNLSLYFAGIDKIASK--YNMVTKIKLIGDIYMAAAGLFNPE 1438
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRV 425
+ M L +L +N +R+ S T+RV V
Sbjct: 1439 TSPESHAEQAVM--LGLDSIAELDEIN--------MRLDSS------------LTIRVGV 1476
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
GG +I AGV+G KP +DI G+ +NVA+R+ ST +H+ ++Q
Sbjct: 1477 NSGGPII--------------AGVLGTDKPAFDIIGDPINVAARLQSTDEANHVHISQAT 1522
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFLEGV 518
YD++ + + R +KGKG +TY + V
Sbjct: 1523 YDLIKGMSFDIAARVETFLKGKGKQMTYLVNPV 1555
>UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to guanylate cyclase - Nasonia vitripennis
Length = 1542
Score = 75.4 bits (177), Expect = 5e-12
Identities = 70/228 (30%), Positives = 105/228 (46%), Gaps = 45/228 (19%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E D V + F+ I F+ E + + + LN++ FD I+ + K+++
Sbjct: 965 EAFDLVTIYFSDIVGFTAMSAE----STPFQVVNFLNDLYTLFDRIIKGYD---VYKVET 1017
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPS 410
G YM SGL G RH +A +L L L V H+ + PS
Sbjct: 1018 IGDAYMVVSGLPIKN----GNRHAGEIASMSLEL---LNAVKHHTI---------AHRPS 1061
Query: 411 DATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRM 470
+ TL++R+ GI+ GPVVAGV+G P+Y ++G+ VN ASRM
Sbjct: 1062 E--------TLKLRI-------------GIHTGPVVAGVVGLTMPRYCLFGDTVNTASRM 1100
Query: 471 DSTGLLDHIQVTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFLEG 517
+S G I ++ + D L GY + RG V +KGKG + TY+L G
Sbjct: 1101 ESNGEPLRIHISAQCKDALDKIGGYVIEERGLVQMKGKGEVKTYWLTG 1148
>UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA; n=2;
Endopterygota|Rep: PREDICTED: similar to CG9783-PA -
Tribolium castaneum
Length = 1044
Score = 75.4 bits (177), Expect = 5e-12
Identities = 37/84 (44%), Positives = 54/84 (64%), Gaps = 1/84 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARG 493
R+ G++ GP AGV+G P+Y ++G+ VN ASRM+STG I +++ + L A G
Sbjct: 946 RLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIHLSEATKERLEKAGG 1005
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEG 517
Y+L RG ++KGKG M TY+L G
Sbjct: 1006 YQLEYRGPTEIKGKGTMHTYWLLG 1029
>UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon
nigroviridis|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 549
Score = 75.4 bits (177), Expect = 5e-12
Identities = 40/87 (45%), Positives = 55/87 (63%), Gaps = 4/87 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T R+ +P L +R AGI+ GPVVAGV+G + P+Y ++G+ VN ASRM+ST L I
Sbjct: 427 TFRIPHKPNTQLQIR---AGIHSGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSLALKI 483
Query: 480 QVTQEVYDIL-SARGYKLRCRGTVDVK 505
Q + + +L GY L CRGT+ VK
Sbjct: 484 QCSSSTFYLLQEIGGYSLECRGTLQVK 510
>UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 408
Score = 75.4 bits (177), Expect = 5e-12
Identities = 35/87 (40%), Positives = 53/87 (60%), Gaps = 1/87 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN GP+VAGVIG K YD+WG+ VN ASRM+S G ++ + ++ + ++ ++
Sbjct: 300 GINTGPLVAGVIGKNKFAYDVWGDTVNTASRMESNGEVNKVNISGVTHQLVKDY-FECEY 358
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDD 525
RG V+VKGKG + YF+ + D
Sbjct: 359 RGKVNVKGKGEVDMYFVNRIKPEFASD 385
Score = 46.8 bits (106), Expect = 0.002
Identities = 44/166 (26%), Positives = 83/166 (50%), Gaps = 21/166 (12%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+KE ++ +A + +LL NILPE +A+ S ++ +A+ ++V V+FA I
Sbjct: 159 KKEQIKQEKAKSDELLLNILPEDIAEELKASGRS----EARNY-----NTVSVLFADIKG 209
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL--TN 363
F+ ++ + ++ L FDEI+ E ++ +EKIK+ G YMAA G+ N
Sbjct: 210 FTTAAEKM----SAADVVKHLEYYFTAFDEIM--EKYE-LEKIKTIGDAYMAAGGIPQPN 262
Query: 364 STQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
++ L M ++ + +E + N+ C+ +R+G + P
Sbjct: 263 TSNSLEMVCAALEMQNFMRQHKEARRSSND---LCWELRLGINTGP 305
>UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulator;
n=1; Microscilla marina ATCC 23134|Rep: Two-component
hybrid sensor and regulator - Microscilla marina ATCC
23134
Length = 1269
Score = 75.4 bits (177), Expect = 5e-12
Identities = 33/90 (36%), Positives = 56/90 (62%), Gaps = 1/90 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G+N G V+AGVIG +K YD+WG++VN A+RM+S G + + ++ Y+++ +
Sbjct: 1165 VRLGVNTGEVIAGVIGTKKFAYDVWGDSVNTAARMESGGKVGEVNISHNTYEMVKDY-FD 1223
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGDSIPDD 525
+ RG V+ KGKG + YF++ + + D
Sbjct: 1224 VEHRGKVNAKGKGEVDMYFVKRIKSELSAD 1253
Score = 41.5 bits (93), Expect = 0.078
Identities = 39/122 (31%), Positives = 57/122 (46%), Gaps = 17/122 (13%)
Query: 243 ANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFAS 302
A E++ E + N LL NILPE VA + K ++ A V+F
Sbjct: 1025 ATLEQKIEERTEEINT-LLLNILPEEVANDLKTNGKAPVKYYAMST---------VLFTD 1074
Query: 303 IPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLT 362
F++ E++ E + LNE A FD+I+ E + +EKIK+ G YMAA G+
Sbjct: 1075 FQGFTKQASEMDSK----ELVEDLNEYFAGFDDIM--EQYN-LEKIKTIGDAYMAAGGIP 1127
Query: 363 NS 364
S
Sbjct: 1128 QS 1129
>UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1174
Score = 75.4 bits (177), Expect = 5e-12
Identities = 71/236 (30%), Positives = 113/236 (47%), Gaps = 48/236 (20%)
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYI 345
Q + EQ + V V F+ I F+ L + + L+NE+ FD I+ E +
Sbjct: 941 QSVEPEQFECVTVFFSDIVQFAA----LSNQMRPLHVVNLMNELYTTFDAIVDEHD---V 993
Query: 346 EKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGK 405
K++S G Y+ SGL N +L H AD AL +++N S FRI
Sbjct: 994 YKVESIGDGYLCVSGLPNRNGNL----HAKQCADMAL------KFLN--SLQSFRI---- 1037
Query: 406 SCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVN 465
+ ++ +R+R+ G++ GP VAGV+G P+Y ++G+ VN
Sbjct: 1038 --------SEHSDQRIRLRI-------------GLHSGPCVAGVVGLAMPRYCLFGDTVN 1076
Query: 466 VASRMDSTGLLDHIQVTQEVYDIL--SARG--YKLRCRGTVDVKGKGNMVTYFLEG 517
ASRM+S+ + I +++E +L ++ G Y RG V +KGKG M T++L G
Sbjct: 1077 TASRMESSSSANKIHISKETCILLHENSEGGAYLTESRGEVIIKGKGVMETFWLLG 1132
>UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A
precursor; n=57; Chordata|Rep: Atrial natriuretic peptide
receptor A precursor - Homo sapiens (Human)
Length = 1061
Score = 75.4 bits (177), Expect = 5e-12
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>UniRef50_A2FZG6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=4; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1552
Score = 74.9 bits (176), Expect = 7e-12
Identities = 34/83 (40%), Positives = 56/83 (67%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ GIN G P+VAGVIG KP ++I G A+N+A M++ G+ + +++ VY+++ +
Sbjct: 1470 RIRVGINTGGPIVAGVIGTEKPTFEILGPAINIAHEMENKGVPMKVHISRPVYELIYGQQ 1529
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ ++ RG +DVKG G M TY +E
Sbjct: 1530 FDIKERGEIDVKG-GKMFTYLVE 1551
Score = 44.4 bits (100), Expect = 0.011
Identities = 39/145 (26%), Positives = 65/145 (44%), Gaps = 17/145 (11%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
+LA+ILP + +KNI F Q S V+F + F+ + G+++
Sbjct: 1347 MLASILPAMLVPRVQAGEKNIS-FSVQ--------SATVLFLDVVEFTPWC----GSHDA 1393
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+R+LN + +FD I K + KIK G YMAA G+ + H + D
Sbjct: 1394 QYVMRMLNIMFKEFDAIT--NAHKTMTKIKCIGDCYMAAGGIFDEVNQPA--VHAKEVVD 1449
Query: 380 YALRLREQLQYVNEHSFNCFRIRIG 404
+ + ++L ++E RIR+G
Sbjct: 1450 FGCLVIKKLLDIDEKENEKLRIRVG 1474
>UniRef50_A2DKP6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=17; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1548
Score = 74.9 bits (176), Expect = 7e-12
Identities = 34/83 (40%), Positives = 56/83 (67%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ GIN G P+VAGVIG KP ++I G A+N+A M++ G+ + +++ VY+++ +
Sbjct: 1466 RIRVGINTGGPIVAGVIGTEKPTFEILGPAINIAHEMENKGVPMKVHISRPVYELIYGQQ 1525
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ ++ RG +DVKG G M TY +E
Sbjct: 1526 FDIKERGEIDVKG-GKMFTYLVE 1547
Score = 45.2 bits (102), Expect = 0.006
Identities = 39/145 (26%), Positives = 66/145 (45%), Gaps = 17/145 (11%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
+LA+ILP + +KNI F Q S V+F + F+ + G+++
Sbjct: 1343 MLASILPPMLVPRVQAGEKNIS-FSVQ--------SATVLFLDVVEFTPWC----GSHDA 1389
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMAD 379
+R+LN + +FD I K + KIK G YMAA G+ + H + D
Sbjct: 1390 QYVMRMLNIMFKEFDAIT--NAHKTMTKIKCIGDCYMAACGIFDEVNQPA--VHAKEVVD 1445
Query: 380 YALRLREQLQYVNEHSFNCFRIRIG 404
+ + ++L ++E+ RIR+G
Sbjct: 1446 FGTLVIKKLLEIDENENENLRIRVG 1470
>UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6;
Diptera|Rep: Soluble guanylate cyclase 89Db - Drosophila
melanogaster (Fruit fly)
Length = 669
Score = 74.9 bits (176), Expect = 7e-12
Identities = 38/80 (47%), Positives = 52/80 (65%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
+ GIN GPVVAGV+G + P+Y ++G+ VN ASRM+S+ IQ++ + GYK
Sbjct: 585 IRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYK 644
Query: 496 LRCRGTVDVKGKGNMVTYFL 515
+ RG V VKGKG M TY+L
Sbjct: 645 VEARGFVKVKGKGEMETYWL 664
Score = 38.3 bits (85), Expect = 0.73
Identities = 41/172 (23%), Positives = 80/172 (46%), Gaps = 27/172 (15%)
Query: 242 QANEEKEDMEHLQAYNRK---LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCV 298
+++E ++ +E ++ R+ LL +++P +A+ S++++ Q + V V
Sbjct: 445 RSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQ---------SFEEVSV 495
Query: 299 MFASIPNFSEFYVELEGN-NEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
+F + N Y N + ++ + LN++ + DE + PF Y K+++ G YMA
Sbjct: 496 IFIEVMNI---YDSGSNNIQDAMQAVTTLNKVFSALDEEIIS-PFVY--KVETVGMVYMA 549
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
SG + V H D ALR+ ++ V H+ IR+G + P
Sbjct: 550 VSGAPD-----VNPLHAEHACDLALRV---MKKVKAHALPGVAIRVGINSGP 593
>UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep:
Guanylate cyclase - Asterias amurensis (Starfish)
Length = 1067
Score = 74.5 bits (175), Expect = 9e-12
Identities = 39/80 (48%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
GI+ G VAGV+G P+Y ++G+ VN ASRM+S GL I V+ E +L GY L
Sbjct: 971 GIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALKIHVSPECRQVLQELGGYNLV 1030
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG V +KGKG ++TY+LEG
Sbjct: 1031 ERGLVAMKGKGEILTYWLEG 1050
>UniRef50_A2F3J3 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=6; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1576
Score = 74.5 bits (175), Expect = 9e-12
Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 50/271 (18%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
++++ E +A + KLL ILP+ + + +I S + F I
Sbjct: 1330 QKRKAAEEAKAKSEKLLYQILPKDIVVRLNRGETDISF---------TIPSATIFFIDIV 1380
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FS + L + E + L+ + A FD+I+ E P I KIK G YMAA+GL +
Sbjct: 1381 KFSNYTATLTPS----EIMANLSLVFATFDKIVGEYPI--ITKIKLIGDVYMAAAGLFCT 1434
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVR 424
+D ++ LR ++ ++ +N +++ SA+ +R+
Sbjct: 1435 EED-DPKKYAEDSVRACLRCQKAMEEIN--------VKL------------SASLEVRIG 1473
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
V GG LI GV+G+ KP +DI G+ +NVA+R+ ST + +Q++ +
Sbjct: 1474 VNSGGPLI--------------GGVLGSDKPTFDIIGDPINVAARLQSTDIPGCVQISGD 1519
Query: 485 VYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
++ + + RG + +KGKGN +TYF+
Sbjct: 1520 TKTLIEGLDFVIEERGEIYLKGKGNRLTYFV 1550
>UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n=23;
Eukaryota|Rep: Retinal guanylyl cyclase 1 precursor -
Homo sapiens (Human)
Length = 1103
Score = 74.1 bits (174), Expect = 1e-11
Identities = 44/104 (42%), Positives = 61/104 (58%), Gaps = 5/104 (4%)
Query: 416 SANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL 475
SA T R+R P + R+ G++ GP VAGV+G P+Y ++G+ VN ASRM+STGL
Sbjct: 958 SAVGTFRMRHMPE---VPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1014
Query: 476 LDHIQVTQEVYDILSA--RGYKLRCRGTVDVKGKGNMVTYFLEG 517
I V IL A GY++ RG ++KGKG T++L G
Sbjct: 1015 PYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
Score = 39.1 bits (87), Expect = 0.42
Identities = 44/167 (26%), Positives = 71/167 (42%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + +LL +LP VA+ + Y EQ V + F+ I
Sbjct: 837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP------VEPEYFEQ---VTLYFSDIV 887
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 888 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPQR 940
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 941 N----GQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGP 983
>UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n=1;
Beggiatoa sp. PS|Rep: Rh-like protein/ammonium
transporter - Beggiatoa sp. PS
Length = 391
Score = 73.7 bits (173), Expect = 2e-11
Identities = 38/78 (48%), Positives = 48/78 (61%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ GPV+AGVIG RK YD+WG+ VN ASRM+S G+ QVT+ Y L Y
Sbjct: 304 GLHSGPVIAGVIGKRKFIYDLWGDTVNTASRMESHGIPGETQVTEGTYLRLKT-DYIFET 362
Query: 499 RGTVDVKGKGNMVTYFLE 516
R + VKGKG M Y L+
Sbjct: 363 RPPIMVKGKGEMPVYLLK 380
>UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate or guanylate cyclase
- Algoriphagus sp. PR1
Length = 638
Score = 73.7 bits (173), Expect = 2e-11
Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
GIN GPVVAG++G +K QYDIWG+ VN A RM+++ ++ I +++ Y +L +
Sbjct: 553 GINSGPVVAGIVGIKKFQYDIWGDTVNTAQRMEASCEINQINISENTYSLLKDDPDFTFI 612
Query: 498 CRGTVDVKGKGNMVTYFLE 516
RG + VKGKG M ++++
Sbjct: 613 ERGILPVKGKGEMKMWYID 631
Score = 40.7 bits (91), Expect = 0.14
Identities = 36/107 (33%), Positives = 49/107 (45%), Gaps = 16/107 (14%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
KLL NILP VA+ K DA++ D V V+F +F++ L
Sbjct: 427 KLLLNILPAEVAEEL----KTKGSSDAKDF-----DQVTVIFTDFADFTKKAQHLSAK-- 475
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
E ++ LN FDEI +EKIK+ G YMAA GL + +
Sbjct: 476 --ELVKELNTCFKTFDEITYNLG---LEKIKTIGDAYMAAGGLNSKS 517
>UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1073
Score = 73.7 bits (173), Expect = 2e-11
Identities = 37/85 (43%), Positives = 56/85 (65%), Gaps = 2/85 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYD--ILSAR 492
R+ GI+ G V AGV+G P+Y ++G+ VNVASRM+ST + IQ++QE D +
Sbjct: 972 RIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYS 1031
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG 517
+++ RGTV+ KGKG + +Y+L G
Sbjct: 1032 EFQITLRGTVEAKGKGPVTSYWLLG 1056
>UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1574
Score = 73.7 bits (173), Expect = 2e-11
Identities = 32/81 (39%), Positives = 54/81 (66%), Gaps = 1/81 (1%)
Query: 436 VPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
+ GIN G P++AGV+G KP +DI G+ +NVASR+ ST ++HI V++E +++ + +
Sbjct: 1476 IRVGINTGGPIIAGVLGTDKPLFDIIGDPINVASRLQSTSAVNHIHVSKETAELVKSMNF 1535
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
+ RG +KGKG T+++
Sbjct: 1536 DVIPRGQTALKGKGTQQTFYI 1556
Score = 39.5 bits (88), Expect = 0.32
Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 23/167 (13%)
Query: 244 NEEKEDMEHLQAYNRK-----LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC- 297
N+EK M+ QA + K LL ILP + + +I F+ S C
Sbjct: 1330 NDEKLVMQMKQAEDEKKKSEKLLYQILPRDIVNQINRGENDIS-FNV---------STCS 1379
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
++F I FSE+ L + + L+ + D+ A+ P + KIK G YM
Sbjct: 1380 IIFIDINKFSEYAANLTPSM----IMTNLSFYFSVLDKTAAKYPL--LTKIKLIGDIYMG 1433
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
ASGL T+D+ H +AL + Q+ +N+ IR+G
Sbjct: 1434 ASGLF-PTEDMTNESHAEQTCLFALDVMYQMDEINKRLDTSLGIRVG 1479
>UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic
peptide receptor A - Strongylocentrotus purpuratus
Length = 853
Score = 73.3 bits (172), Expect = 2e-11
Identities = 40/97 (41%), Positives = 60/97 (61%), Gaps = 4/97 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ ++R P L +R AGI+ GP VAGVIG + P+Y ++G+ VN ASRM+S G I
Sbjct: 748 SFKIRHRPDEQLKLR---AGIHSGPCVAGVIGLKMPRYCLFGDTVNTASRMESNGEAMKI 804
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFL 515
+ + +IL ++L RG V++KGKG+ TY+L
Sbjct: 805 HASSDCKEILDKFDAFELDLRGQVEMKGKGSQTTYWL 841
>UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific;
n=1; Dictyostelium discoideum|Rep: Adenylate cyclase,
aggregation specific - Dictyostelium discoideum (Slime
mold)
Length = 1407
Score = 73.3 bits (172), Expect = 2e-11
Identities = 47/124 (37%), Positives = 63/124 (50%), Gaps = 2/124 (1%)
Query: 397 NCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQ 456
N + G SPS S + L V+ I R V GI+ GP+VAG IG + +
Sbjct: 1238 NTYMAVSGLDGSPSFLEKMS-DFALDVKAYTNSVAISRVVRIGISHGPLVAGCIGISRAK 1296
Query: 457 YDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLE 516
+D+WG+ N ASRM S + I VT VY+ L+ Y + VKGKG MVT+ L+
Sbjct: 1297 FDVWGDTANTASRMQSNAQDNEIMVTHSVYERLNKLFY-FDDEKEILVKGKGKMVTHVLK 1355
Query: 517 GVGD 520
G D
Sbjct: 1356 GKKD 1359
Score = 47.6 bits (108), Expect = 0.001
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 17/122 (13%)
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
+Y + V +MF I F E+ +E + ++ LN+I + FD +L ++ +EK
Sbjct: 1180 VYVQPHQDVSIMFIQIAGFQEY-------DEPKDLIKKLNDIFSFFDGLLNQKYGGTVEK 1232
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
IK+ G TYMA SGL S L M+D+AL ++ Y N + + +RIG S
Sbjct: 1233 IKTIGNTYMAVSGLDGSPSFL------EKMSDFALDVK---AYTNSVAISRV-VRIGISH 1282
Query: 408 SP 409
P
Sbjct: 1283 GP 1284
Score = 39.5 bits (88), Expect = 0.32
Identities = 31/137 (22%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFD 284
H E + FI + + +E +++ + + KLL NILP+ + ++ + + D
Sbjct: 369 HLYVLEKFRKESFIAEKKLIKESNILKNEKEKSSKLLNNILPDFIIENIVYDFEKRDIVI 428
Query: 285 AQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ ++ C +C I F+ +L+ + V+ LL ++ +FD ++
Sbjct: 429 PEPEEYKSCSILCF---DIVQFTNMSAKLDSPSRLVD---LLTQVFREFDTVVLRNG--- 479
Query: 345 IEKIKSTGATYMAASGL 361
+KIK+ G Y+ A GL
Sbjct: 480 CQKIKTDGDAYICACGL 496
Score = 37.5 bits (83), Expect = 1.3
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
GI G V GVIG++K Q+DIWG+ + + ++ G + V + +
Sbjct: 629 GIAAGSVYGGVIGSQKYQFDIWGDTIARSHTLEQLGQPGKVHVGETI 675
>UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000009149 - Nasonia
vitripennis
Length = 1329
Score = 72.9 bits (171), Expect = 3e-11
Identities = 38/88 (43%), Positives = 55/88 (62%), Gaps = 1/88 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
GI+ GPV AGV+G + P+Y ++G+ VN ASRM+STG I + E +L G+ L
Sbjct: 998 GIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGSPLRIHCSTETKQLLDQLGGFSLA 1057
Query: 498 CRGTVDVKGKGNMVTYFLEGVGDSIPDD 525
RG V +KGKG +TY+L G S+ ++
Sbjct: 1058 ERGLVSMKGKGERLTYWLIGEEPSMREE 1085
>UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2703
Score = 72.9 bits (171), Expect = 3e-11
Identities = 70/255 (27%), Positives = 113/255 (44%), Gaps = 40/255 (15%)
Query: 261 LANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
L+ +LP + + L S +N D+ + +V V+F I NF E ++ E
Sbjct: 1816 LSILLPRFIREK-LYSGQNYDKISTNQ------GNVAVLFCDITNFDEIMMQ-----EEE 1863
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLV-GYRHVTAMAD 379
+ +++L+ + FD+ + KI++ G TYMAA+GL + + G V D
Sbjct: 1864 KIVKVLDNLFRQFDKSCQANQ---VLKIETVGKTYMAAAGLRDVDEYYQDGQNQVNTFVD 1920
Query: 380 YALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAG 439
R C ++ + + T + N GG + G
Sbjct: 1921 PVKR--------------CLQVAMEMQEIAKNITWGNTN--------NGGKSGKVEIKIG 1958
Query: 440 INIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYD-ILSARGYKLRC 498
IN G V++GVIG KPQ+ + G+ VN ASR+ STGL I ++ Y ++ Y+
Sbjct: 1959 INYGTVISGVIGFHKPQFSLIGDTVNTASRVCSTGLPKTINISNSSYQKVIQLSQYRFEK 2018
Query: 499 RGTVDVKGKGNMVTY 513
R V+ KGKG + TY
Sbjct: 2019 R-EVEAKGKGIITTY 2032
Score = 44.8 bits (101), Expect = 0.008
Identities = 26/82 (31%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK--- 495
G++ G +V G++G + +YDI+G V +A++M+S G + V++ DIL R K
Sbjct: 2618 GVHTGKIVGGLVGTQIVRYDIYGVDVMIANKMESNGQKGSVVVSETTKDILQERYGKEFI 2677
Query: 496 LRCRGTVDVKGKG-NMVTYFLE 516
+G V +K N+ T+F +
Sbjct: 2678 FTEKGDVYIKATDTNIRTFFCD 2699
Score = 34.7 bits (76), Expect = 9.0
Identities = 36/166 (21%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 245 EEKEDMEHLQAYNRK------LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCV 298
+++E+ LQ+ N K L+ +LP+H+ + FL + A + E+ D +
Sbjct: 2468 KDQENFNTLQSLNEKNQQTDKLIQYLLPKHILERFLMNP------TASYIIAEKFDKQTI 2521
Query: 299 MFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAA 358
+FA I F+ + N+ +++L I +FD+ + + + K+ + G Y+
Sbjct: 2522 LFADIAGFTRY----SDQNQPETVVKMLRTIFTEFDQ---KCQYHKVFKVYTIGDCYVIL 2574
Query: 359 SGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+ +D + M A ++ E L+ E N +RIG
Sbjct: 2575 GNTNHENRDPPTEAYNVIM--MAFQMIEILKRTTELVENQIDMRIG 2618
>UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1416
Score = 72.9 bits (171), Expect = 3e-11
Identities = 32/81 (39%), Positives = 55/81 (67%), Gaps = 1/81 (1%)
Query: 436 VPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
V G+N G P++ GV+G KP +DI G+ +NVA+R+ ST + ++Q+++E +++ + +
Sbjct: 1315 VRVGVNSGGPLIGGVLGTDKPTFDIIGDPINVAARLQSTDIPGNVQISEETKNLIESSDF 1374
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
+ RG V +KGKGN TYF+
Sbjct: 1375 IIEERGEVYLKGKGNRKTYFV 1395
Score = 50.8 bits (116), Expect = 1e-04
Identities = 39/160 (24%), Positives = 73/160 (45%), Gaps = 15/160 (9%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
+++ D E +A + KLL ILP+ + +K+I + F I
Sbjct: 1174 KKRNDAEQAKAKSEKLLYQILPKDIVVRLNRGEKDISF---------SIPIATIFFIDIV 1224
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FS + L + E ++ L+ + A FD+ +++ ++ I KIK G YMAA+GL N+
Sbjct: 1225 KFSNYSATLSPS----EIMQNLSLVFATFDKNVSK--YQSITKIKLIGDVYMAAAGLFNN 1278
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+ H T + L+ + + +N + + +R+G
Sbjct: 1279 ADEKTAKDHATEAVNCCLQCIKSMTDINTNLESSLEVRVG 1318
>UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 72.9 bits (171), Expect = 3e-11
Identities = 72/271 (26%), Positives = 120/271 (44%), Gaps = 51/271 (18%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E+K E+ + + LL ILP + L +KNI + +S + F I
Sbjct: 1348 EQKRQAENEKMKSENLLYQILPRDIV---LQINKNIKEISFN------VNSATICFIDIN 1398
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FSE+ L NN + L+ + D+ L E P + KIK G YMAA G+ N+
Sbjct: 1399 KFSEYTTNLTPNN----IMSNLSYYFSVLDQTLKEYPL--LIKIKLIGDIYMAAGGIFNN 1452
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVR 424
D+ H M + + L+ +N+ + +IRIG
Sbjct: 1453 --DVGPEVHAEQMILFCFDVLYHLEEINKKLDSNLQIRIG-------------------- 1490
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ GG LI AG+ +G KP +DI G+ +NVA+R+ ST ++ + ++ +
Sbjct: 1491 INTGGPLI-----AGV---------LGTDKPLFDIIGDPINVAARLQSTSDVNKVHISGD 1536
Query: 485 VYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
++++ Y + RG +KGKG +TY++
Sbjct: 1537 TFELVKGLNYDITKRGETFLKGKGKQITYYI 1567
>UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2;
Tetraodontidae|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 510
Score = 72.5 bits (170), Expect = 4e-11
Identities = 71/250 (28%), Positives = 119/250 (47%), Gaps = 36/250 (14%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
KLL+++LP+++A L + K+++ + + V V F+ I F+ +
Sbjct: 266 KLLSSMLPKYIADQ-LMAGKSVEP--------QSYNLVTVFFSDIVGFTSMCAL----SS 312
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
+E + LN++ + FD+I+ + K+++ G YM ASG+ + G +H ++
Sbjct: 313 ALEVVSFLNDLYSLFDDIIRMYD---VYKVETIGDAYMVASGVPIAN----GNKHAIEIS 365
Query: 379 DYALRLREQLQYVNEHSF--NCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRV 436
AL ++ H IRIG + A A T R G V
Sbjct: 366 TMALHFLSSIKVFKIHHMPTETLAIRIGIHSGGTRA----AEVTNR---RSGATETV--- 415
Query: 437 PAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI-LSARGYK 495
G +GPVVAGV+G P+Y ++G+ VN+ASRM+S I V+Q DI L A ++
Sbjct: 416 --GF-VGPVVAGVVGTAMPRYCLFGDTVNMASRMESNSSALKIHVSQRTADILLQAGSFE 472
Query: 496 LRCRGTVDVK 505
L RG +++K
Sbjct: 473 LEERGEIEIK 482
>UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:
Adenylate cyclase - Leptospira interrogans
Length = 492
Score = 72.5 bits (170), Expect = 4e-11
Identities = 38/79 (48%), Positives = 50/79 (63%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGVIG K YD+WG++VN ASRM+S G I ++ VY+ + +
Sbjct: 413 GIHTGDVVAGVIGKNKFVYDLWGDSVNTASRMESHGEPGRIHCSEAVYESIKDL-FLFEE 471
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG M T+FL G
Sbjct: 472 RGVIPVKGKGPMRTFFLLG 490
Score = 47.6 bits (108), Expect = 0.001
Identities = 46/156 (29%), Positives = 75/156 (48%), Gaps = 22/156 (14%)
Query: 250 MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEF 309
+E + + LL NILP+ A+ + I + + V+FA I FS+
Sbjct: 279 LEKERQKSESLLLNILPKSTAERLKAGEVVIADYIKKST---------VLFADIVGFSKL 329
Query: 310 YVELEGNNEGVECLRLLNEIIADFDEILAEEPFKY-IEKIKSTGATYMAASGLTNSTQDL 368
++ N+ VE +LN+I FD+I + KY +EKIK+ G YM A G+ +T+D
Sbjct: 330 STQIPTPNQLVE---ILNQIFTCFDDIAS----KYQLEKIKTIGDCYMMAGGIPIATED- 381
Query: 369 VGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
HV +A + + + L+ + + F IRIG
Sbjct: 382 ----HVEKIALAGIDMIQGLKDLQKSWKYEFNIRIG 413
>UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1295
Score = 72.5 bits (170), Expect = 4e-11
Identities = 74/271 (27%), Positives = 125/271 (46%), Gaps = 51/271 (18%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+K+ E +A + KLL ILP + +K+I F +S ++F I
Sbjct: 1061 QKKQAEEAKAKSEKLLYQILPRDIVVQLNKGEKDIT-FTV--------NSATIIFIDINK 1111
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
FSE L + + L+ A D+I A+ + I KIK G YMAA+GL N
Sbjct: 1112 FSECSKNLSPQ----DIMSNLSYYFACIDKISAK--YNMILKIKLIGDIYMAAAGLFN-- 1163
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRV 425
++ +H A+ A+ +++ + E +R+ SAN +RV V
Sbjct: 1164 PEVNPEQH----AEQAVLFGQEIVNILEE----INLRL------------SANLQIRVGV 1203
Query: 426 EPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEV 485
G GP++AGV+G KP +DI G+ +NVA+R+ ST ++ + ++Q
Sbjct: 1204 NSG--------------GPIIAGVLGTDKPAFDIIGDVINVAARLQSTSDVNKVHISQAT 1249
Query: 486 YDILSARGYKLRCRGTVDVKGKGNMVTYFLE 516
D++ ++ G +KGKG +TY+++
Sbjct: 1250 LDLVKGMNCEVTQCGETFLKGKGKQLTYYVK 1280
>UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3;
Diptera|Rep: Guanylate cyclase 32E precursor - Drosophila
melanogaster (Fruit fly)
Length = 1163
Score = 72.5 bits (170), Expect = 4e-11
Identities = 38/96 (39%), Positives = 59/96 (61%), Gaps = 4/96 (4%)
Query: 421 LRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQ 480
L++R +P + +R G++ GP AGV+G + P+Y ++G+ VN ASRM+STG I
Sbjct: 956 LKIRHKPTETVQLR---IGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIH 1012
Query: 481 VTQEVYDILSARG-YKLRCRGTVDVKGKGNMVTYFL 515
+++ Y +L G Y RG +KGKG+M TY+L
Sbjct: 1013 ISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1048
>UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-35 -
Caenorhabditis elegans
Length = 688
Score = 72.5 bits (170), Expect = 4e-11
Identities = 33/84 (39%), Positives = 55/84 (65%), Gaps = 2/84 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL--LDHIQVTQEVYDILSAR 492
++ G++ GPVVAGV+G + P+Y ++G+ VNVA++M+S G+ H+ T ++ + +
Sbjct: 516 KIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSETGKLNGLKANP 575
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLE 516
Y RG +++GKG M TYFLE
Sbjct: 576 SYVFIDRGNTEIRGKGMMYTYFLE 599
>UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=1;
Methylobacterium sp. 4-46|Rep: Response regulator
receiver protein - Methylobacterium sp. 4-46
Length = 531
Score = 72.1 bits (169), Expect = 5e-11
Identities = 40/93 (43%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 426 EPGGALIVR-RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
E G AL V V GI+ G VAGVIG + YD+WG++VN+A+RM+S G I +++
Sbjct: 433 EVGRALGVELAVRVGIHSGEAVAGVIGQSRFAYDVWGDSVNIAARMESHGQAGRIHISES 492
Query: 485 VYDILSARGYKLRCRGTVDVKGKGNMVTYFLEG 517
L + RG +KGKG M TYFL+G
Sbjct: 493 TRRALGG-DFFCTPRGVTHIKGKGPMETYFLDG 524
Score = 35.1 bits (77), Expect = 6.8
Identities = 32/119 (26%), Positives = 52/119 (43%), Gaps = 16/119 (13%)
Query: 249 DMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSE 308
+ + L+ +LL N+LP + + I AQ V V+F + F+
Sbjct: 313 ERKFLREREERLLLNVLPRPILARMRNGEAAIADRFAQ---------VTVLFCDLVGFTP 363
Query: 309 FYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
L G + LL+ + + FD +A + +EKIK+ G YMAA G+ +T D
Sbjct: 364 ----LAGRLTPGGTVDLLSRVFSAFDRSVAR---RGVEKIKTIGDAYMAAGGIPETTPD 415
>UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 544
Score = 72.1 bits (169), Expect = 5e-11
Identities = 32/80 (40%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G ++AGVIG +K YD+WG+ VN ASRM+S+G + + ++ + Y+++ ++
Sbjct: 435 GINTGKLIAGVIGKKKFAYDVWGDTVNTASRMESSGEVGKVNISGKTYELVK-DFFECEH 493
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
RG V KGKG + YF+ +
Sbjct: 494 RGKVTAKGKGEIDMYFVRRI 513
>UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1;
Microscilla marina ATCC 23134|Rep: Heat-stable
enterotoxin receptor - Microscilla marina ATCC 23134
Length = 711
Score = 72.1 bits (169), Expect = 5e-11
Identities = 31/78 (39%), Positives = 51/78 (65%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G ++AGV+G +K YDIWG+ VN+ASRM+S G + ++ + Y ++ ++
Sbjct: 632 GIHTGEIIAGVVGKKKFAYDIWGDTVNLASRMESGGEAGKVNISGDTYALIKDH-FQCEY 690
Query: 499 RGTVDVKGKGNMVTYFLE 516
RG ++ K KGN+ YF+E
Sbjct: 691 RGKINAKNKGNVDMYFVE 708
Score = 36.7 bits (81), Expect = 2.2
Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 16/117 (13%)
Query: 250 MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEF 309
+E +A + +LL NILPE A +K + + Y D V V+F F++
Sbjct: 495 IEKEKAKSDELLLNILPEQTATEL--KEKG---YATPQHY----DLVSVLFTDFKGFTKL 545
Query: 310 YVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
++ E + LN FD+IL + +EKIK+ G YMAA G+ + Q
Sbjct: 546 AEKITPQ----EVIEELNYCFTAFDKILEKHN---LEKIKTIGDAYMAAGGIPLANQ 595
>UniRef50_A0LXB4 Cluster: Secreted protein containing
adenylate/guanylate cyclase catalytic domain; n=1;
Gramella forsetii KT0803|Rep: Secreted protein
containing adenylate/guanylate cyclase catalytic domain
- Gramella forsetii (strain KT0803)
Length = 610
Score = 72.1 bits (169), Expect = 5e-11
Identities = 32/83 (38%), Positives = 53/83 (63%), Gaps = 1/83 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G+N GPVVAGV+G +K YDIWG+ VN+A+RM+S + I +++ YD++ + +
Sbjct: 520 VRVGLNSGPVVAGVVGTKKFAYDIWGDTVNIAARMESHSDIGKINISENTYDLIKDK-FD 578
Query: 496 LRCRGTVDVKGKGNMVTYFLEGV 518
RG V+VK + Y+++ +
Sbjct: 579 CEYRGEVEVKNGRILKMYYVKDI 601
>UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1272
Score = 72.1 bits (169), Expect = 5e-11
Identities = 40/103 (38%), Positives = 61/103 (59%), Gaps = 4/103 (3%)
Query: 416 SANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL 475
SA ++R P L++R GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S+G+
Sbjct: 1022 SAVSEFKIRHRPTNRLLLR---IGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGV 1078
Query: 476 LDHIQVTQEVYDILS-ARGYKLRCRGTVDVKGKGNMVTYFLEG 517
I + + +L GY RG + +KGKG+ TY+L G
Sbjct: 1079 PLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLG 1121
>UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1280
Score = 72.1 bits (169), Expect = 5e-11
Identities = 34/81 (41%), Positives = 52/81 (64%), Gaps = 2/81 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA--RGYKL 496
G++ GP VAGV+G P+Y ++G+ VN ASRM+S G I + +L++ +G+ L
Sbjct: 1126 GMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLL 1185
Query: 497 RCRGTVDVKGKGNMVTYFLEG 517
RG++ +KGKG M TY+L G
Sbjct: 1186 EERGSLAIKGKGQMTTYWLNG 1206
Score = 35.1 bits (77), Expect = 6.8
Identities = 37/166 (22%), Positives = 65/166 (39%), Gaps = 17/166 (10%)
Query: 244 NEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
+E +++ Q ++ LL +LP VA+ L Q++ E V + F+ I
Sbjct: 983 DERTIELKDEQRRSQHLLQRMLPSSVAEQLLAG---------QDVIPEAFPPVTIYFSDI 1033
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTN 363
F+ + G + +E + LN++ FD I+ + K+++ G YM SG+
Sbjct: 1034 VGFTT----ISGESTPMEVVTFLNKLYTLFDSIIRRYD---VYKVETIGDAYMVVSGVPQ 1086
Query: 364 STQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
+ MA + L + S IRIG P
Sbjct: 1087 YKTMEYHAEQIAMMAIHILSAVRSFS-IPHRSCEPLMIRIGMHTGP 1131
>UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus
japonicus|Rep: Guanylate cyclase - Stichopus japonicus
(Sea cucumber)
Length = 1075
Score = 72.1 bits (169), Expect = 5e-11
Identities = 36/80 (45%), Positives = 51/80 (63%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG-YKLR 497
GI+ GP VAGV+G + P+Y ++G+ VN ASRM+S G I V+ IL G + L
Sbjct: 978 GIHSGPAVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSSTKKILDLFGTFVLE 1037
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG +++KGKG TY+L+G
Sbjct: 1038 KRGEIEMKGKGVQTTYWLQG 1057
>UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1612
Score = 72.1 bits (169), Expect = 5e-11
Identities = 41/121 (33%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 439 GINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR 497
GIN G P++AGV+G KP +DI G+ +NVA+R+ ST ++ + V+Q +++ Y++
Sbjct: 1432 GINSGGPIIAGVLGTDKPVFDIIGDPINVAARLQSTSEVNRVHVSQATLSLINNITYEVT 1491
Query: 498 CRGTVDVKGKGNMVTYFLE----GVGDSIPDDIYNNPIPSTSSEGAVPPRPEHRPLDTLS 553
RG +KGKG +TY++ + DS P + + + + AV PR LD S
Sbjct: 1492 PRGETFLKGKGKQLTYYITIADVNINDSPPQSKFESKL--SLHNIAVNPRNSLANLDLFS 1549
Query: 554 E 554
+
Sbjct: 1550 K 1550
Score = 43.2 bits (97), Expect = 0.026
Identities = 44/159 (27%), Positives = 64/159 (40%), Gaps = 17/159 (10%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+K+ E + + KLL ILP + +K+I S ++F I
Sbjct: 1291 QKKQAEEAKMKSEKLLYQILPRDIVLKLNKGEKDISFV---------VPSATIIFIDINK 1341
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
FSE+ L + L+ A D + + + I+KIK G YMAASGL N
Sbjct: 1342 FSEYSKNLTPQ----AIMSNLSYYFAQLDRVAGK--YGMIQKIKLIGDIYMAASGLFN-- 1393
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
D H ++L + L VN H + IRIG
Sbjct: 1394 PDSPPESHAEQAVQFSLACLDALDDVNIHLDSHLEIRIG 1432
>UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta-3; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta-3 - Strongylocentrotus purpuratus
Length = 818
Score = 71.7 bits (168), Expect = 6e-11
Identities = 38/95 (40%), Positives = 59/95 (62%), Gaps = 2/95 (2%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
++P + ++ GI+ G VVAGV+G + P+Y ++G+ VN ASRM+STG I +++
Sbjct: 509 IDPSSKDEIVKIRVGIHTGMVVAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHMSET 568
Query: 485 VYDILSA-RG-YKLRCRGTVDVKGKGNMVTYFLEG 517
L G Y + RG+ +VKGKG+M TY+L G
Sbjct: 569 TKKKLDQWEGYYDIEERGSTNVKGKGSMKTYWLHG 603
>UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta
proteobacterium MLMS-1|Rep: Adenylate cyclase - delta
proteobacterium MLMS-1
Length = 480
Score = 71.7 bits (168), Expect = 6e-11
Identities = 37/85 (43%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
+ GI GPVV+GVIG+ K YD+WG+ VN A+R++S+ L I L Y+
Sbjct: 387 IRVGIATGPVVSGVIGSVKFAYDLWGDTVNAANRLESSALPGRIHCNARFAHRLQEH-YR 445
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGD 520
RG +++KGKG M T FL G GD
Sbjct: 446 FEDRGEIEIKGKGVMHTCFLLGQGD 470
Score = 53.2 bits (122), Expect = 2e-05
Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 25/201 (12%)
Query: 212 IAIALGATVALLLHSQQTES-TYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
+A++LG V L L + + S ++R + + + E++ ++ N +LLANILP +A
Sbjct: 217 LAVSLGLAVLLALLTHRVRSASHRRELKHQRERREKERELALQNQENERLLANILPGPIA 276
Query: 271 QHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
++ I DA EL V V+F + F+ + ++ + LN I
Sbjct: 277 LRLKSGEELI--ADAHEL-------VTVIFIDMTGFTRY----SASHPARRVVDTLNRIF 323
Query: 331 ADFDEILAEEPFKY-IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRL-REQL 388
D++ KY +EKIK+ G YM GL D + H +AD AL L RE
Sbjct: 324 RMIDDL----TLKYRLEKIKTIGDAYMMVGGL-----DPMDDNHPRRVADMALELMREFD 374
Query: 389 QYVNEHSFNCFRIRIGKSCSP 409
+ E F IR+G + P
Sbjct: 375 RLKQELQVTDFSIRVGIATGP 395
>UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Herpetosiphon aurantiacus ATCC 23779|Rep:
Adenylyl cyclase class-3/4/guanylyl cyclase -
Herpetosiphon aurantiacus ATCC 23779
Length = 355
Score = 71.7 bits (168), Expect = 6e-11
Identities = 40/90 (44%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
P G + R+ GI+ GPVVAGVIG K YD+WG+ VN+ASRM+S+ + IQV+ E Y
Sbjct: 262 PNGKPLQMRI--GIHSGPVVAGVIGTIKFSYDLWGDTVNIASRMESSAHPNTIQVSAETY 319
Query: 487 DIL-SARGYKLRCRGTVDVKGKGNMVTYFL 515
+L + L+ R V++K G TY L
Sbjct: 320 ALLQDHEHFSLQPRHGVEMKHLGTRTTYIL 349
Score = 53.6 bits (123), Expect = 2e-05
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 21/156 (13%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
QA + +LL NILP+ +A NI ++ + SV V+FA I F+E L
Sbjct: 143 QAQSNRLLRNILPQTIADQLKDQQANIAEYFS---------SVSVLFADIVGFTE----L 189
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
G+ E + LN + + FD++ + +EKIK+ G YM A+GL + D H
Sbjct: 190 SGHINAKELVAWLNRLFSRFDQMTLDVG---LEKIKTIGDAYMVAAGLPIAQPD-----H 241
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
+A +A + +++ + + ++RIG P
Sbjct: 242 AERLALFATSMLAEIEQITMPNGKPLQMRIGIHSGP 277
>UniRef50_A2G2M4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=9; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1544
Score = 71.7 bits (168), Expect = 6e-11
Identities = 32/83 (38%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ GIN G P++AGVIG KP ++I G A+N A M+ G+ + +++ VY+++ +
Sbjct: 1462 RIRVGINTGGPIIAGVIGTEKPTFEILGPAINTAHEMEHHGVPMKVHISRPVYELIYGQQ 1521
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ ++ RG +D+KG G M TY +E
Sbjct: 1522 FDIKERGEIDIKG-GKMFTYLVE 1543
>UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1523
Score = 71.7 bits (168), Expect = 6e-11
Identities = 76/274 (27%), Positives = 119/274 (43%), Gaps = 54/274 (19%)
Query: 242 QANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFA 301
Q +++E+ E +A + KLL ILP + N D+ D + ++C F
Sbjct: 1260 QLAKQQEEAEKAKATSEKLLYQILPRDIVIRL-----NRDETDIT--FTVNSSTIC--FI 1310
Query: 302 SIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
I FSE+ L E + L+ D I ++ F + KIK G YM ASGL
Sbjct: 1311 DIVKFSEYSSHLSPQ----EIMYNLSYFFGTIDTISSK--FNLLTKIKVIGDIYMCASGL 1364
Query: 362 TNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTL 421
+ + + H M +A +L +N I C N ++
Sbjct: 1365 FDDSNE-----HAEQMILFANEFVRELDEIN----------IKLDC----------NLSV 1399
Query: 422 RVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
R+ V GG P++ V+G KP +DI G+ +NVASR+ ST + I +
Sbjct: 1400 RIGVNSGG--------------PILGCVLGKEKPVFDIIGDPINVASRLQSTSPPNCIHM 1445
Query: 482 TQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
+Q YD++S + ++ RG V +KGKG TY +
Sbjct: 1446 SQGTYDMVSNLNFDIKPRGEVYLKGKGKTNTYLM 1479
>UniRef50_Q6E6T5 Cluster: L3i88 isoform b; n=5; Dictyocaulus
viviparus|Rep: L3i88 isoform b - Dictyocaulus viviparus
(Bovine lungworm)
Length = 242
Score = 71.3 bits (167), Expect = 8e-11
Identities = 36/95 (37%), Positives = 58/95 (61%), Gaps = 2/95 (2%)
Query: 422 RVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV 481
R+ EP G V+ + GIN GP++AGV+ + P+Y ++G V +AS ++ G+ IQ
Sbjct: 59 RLVSEPVGENPVQ-IRIGINTGPIIAGVVTMKMPRYCLFGETVCLASCLEMNGIPGKIQC 117
Query: 482 TQEVYDILSARG-YKLRCRGTVDVKGKGNMVTYFL 515
+++ Y G + +CRG V++KG+G M TYFL
Sbjct: 118 SEKSYKYAMQTGRFDFKCRGRVNIKGRGTMETYFL 152
>UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1025
Score = 71.3 bits (167), Expect = 8e-11
Identities = 35/86 (40%), Positives = 55/86 (63%), Gaps = 2/86 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA--R 492
++ G++ G VAGV+G P+Y ++G+ VN ASRM+S G I ++ + YD+L++ +
Sbjct: 935 QIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLTSLYK 994
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEGV 518
Y RG V +KGKG M TY+L G+
Sbjct: 995 EYNTESRGEVIIKGKGVMQTYWLLGM 1020
Score = 34.7 bits (76), Expect = 9.0
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 7/71 (9%)
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
G + LLN++ FD I+ E+ Y K+++ G Y+ SGL G HV +A
Sbjct: 859 GFTVVNLLNDLYTTFDAII-EKNDSY--KVETIGDAYLVVSGLPRRN----GTEHVANIA 911
Query: 379 DYALRLREQLQ 389
+ +L L + LQ
Sbjct: 912 NMSLELMDSLQ 922
>UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 71.3 bits (167), Expect = 8e-11
Identities = 43/114 (37%), Positives = 63/114 (55%), Gaps = 7/114 (6%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA---RGYK 495
G+N GP VAGV+G P+Y ++G+ VN ASRM+S G I +T + + +L Y
Sbjct: 970 GVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHLLLLTHYPNHYD 1029
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGDSI--PDDIYNNPIPST--SSEGAVPPRPE 545
RG V +KGKG M T+++ G D I P ++ + PST + PP P+
Sbjct: 1030 TSSRGEVIIKGKGVMETFWVHGRIDDIAEPTELRSICKPSTVANERWITPPAPK 1083
>UniRef50_A2DJR4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1241
Score = 71.3 bits (167), Expect = 8e-11
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 3/93 (3%)
Query: 424 RVEPGGALIVRRVPAGINI-GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
R+ GG I + G+N GP+++GV+G KP +D+WG+AVNV++R++++ +D IQ+
Sbjct: 1137 RIGKGGMPIHLNI--GVNYDGPIISGVLGREKPFFDVWGDAVNVSARLETSSYIDTIQML 1194
Query: 483 QEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
Y L Y R R V +KGKG T+++
Sbjct: 1195 PHTYHALPEGIYPARERHDVFLKGKGTTNTFYI 1227
Score = 39.5 bits (88), Expect = 0.32
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 15/129 (11%)
Query: 237 FIWKLQANEEKEDMEHLQAYNR--KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCD 294
FI + K + E A NR LL I+P+ +A + ++ D Q D
Sbjct: 997 FILRDITEYSKNETELRDAQNRVDSLLTKIMPKVIATRLMSKTESEDIIS-------QVD 1049
Query: 295 SVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGAT 354
++F I +F + G+ E +++L+ I + FD+ +A+ P + KIK
Sbjct: 1050 KAVIIFIGIHDFIS-WCSTRGHEE---IMQILDVIFSKFDKKIAKYPT--LVKIKMINGV 1103
Query: 355 YMAASGLTN 363
YMAA+GL N
Sbjct: 1104 YMAAAGLFN 1112
>UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=3; Danio rerio|Rep: PREDICTED:
similar to receptor type guanylyl cyclase - Danio rerio
Length = 479
Score = 70.9 bits (166), Expect = 1e-10
Identities = 35/84 (41%), Positives = 53/84 (63%), Gaps = 1/84 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA-RG 493
RV G++ GP VAGV+G + P+Y ++G+ VN ASRM+S GL I V+ +L R
Sbjct: 393 RVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRN 452
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEG 517
++ RG + +KGKG + T++L G
Sbjct: 453 FRCELRGDIHIKGKGWVRTFWLLG 476
>UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 518
Score = 70.9 bits (166), Expect = 1e-10
Identities = 66/238 (27%), Positives = 109/238 (45%), Gaps = 45/238 (18%)
Query: 281 DQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEE 340
D +++ E D V + F+ I F+ L + ++ + LLN++ FDEI+
Sbjct: 323 DLVHGKQVTAENFDEVSIFFSDIVGFTS----LSSESTPLQVVDLLNDLYTLFDEIINNY 378
Query: 341 PFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFR 400
+ K+++ G YM SGL G++H +A AL + ++ + F+
Sbjct: 379 D---VYKVETIGDAYMVVSGLPIRN----GHQHAGEIATMALHMLREI--------DSFK 423
Query: 401 IRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIW 460
IR P+D LR+ + G + AGV+G + P+Y ++
Sbjct: 424 IR----HRPND------KLKLRIGIHSGSCV---------------AGVVGKKMPRYCLF 458
Query: 461 GNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFLEG 517
G+ VN ASRM+S G I ++ IL GY ++ RG V +KGKG +TY+L G
Sbjct: 459 GDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVG 516
>UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=4; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1585
Score = 70.9 bits (166), Expect = 1e-10
Identities = 28/73 (38%), Positives = 51/73 (69%)
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTV 502
GP++ GV+G KP +DI G+ +NVA+R+ ST + ++Q++Q+ + + +++ RG +
Sbjct: 1491 GPLLGGVLGTDKPTFDIIGDPINVAARLQSTDIPGNVQISQDTKEAIKDLDFEVEERGEI 1550
Query: 503 DVKGKGNMVTYFL 515
+KGKGN +TYF+
Sbjct: 1551 YLKGKGNRITYFV 1563
Score = 46.4 bits (105), Expect = 0.003
Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 16/160 (10%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
++++ E +A + KLL ILP+ + +K+I S + F I
Sbjct: 1343 KKRQAAEEAKAKSEKLLYQILPKDIVVRLNRGEKDISF---------TIPSATIFFIDIV 1393
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FSE+ L E + L+ + A FD I+AE ++ I KIK G YMAA+GL
Sbjct: 1394 KFSEYAALLTPT----EIMANLSLVFATFDNIVAE--YESITKIKLIGDVYMAAAGLFQD 1447
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+D +H + + ++ +N +RIG
Sbjct: 1448 PED-PSLKHAEDAVRCCIACSKAMEEINMKLNASLEVRIG 1486
>UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1096
Score = 70.9 bits (166), Expect = 1e-10
Identities = 32/88 (36%), Positives = 53/88 (60%), Gaps = 1/88 (1%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
++ G+N G P+ G++G +P +DI G+ VNVASRM+ L ++Q++ YD +
Sbjct: 1002 QITCGVNTGGPIKCGILGVTRPVFDIIGDVVNVASRMNLHCLPGYVQISPSTYDAIKYLN 1061
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEGVGDS 521
+ ++ RG + VKGKG M TY + +S
Sbjct: 1062 FNVKERGEIQVKGKGMMKTYVVSASSNS 1089
Score = 35.9 bits (79), Expect = 3.9
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 19/151 (12%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+A KL+ ++LP + + + +I F+ Q+ V+F SI +S ++
Sbjct: 875 KAKGEKLIESLLPPSIIKRMNEGETDIT-FEVQQ--------ATVLFTSIVGWSNLTQDM 925
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
+ + + +LN + +DE L F I K+K+ G YM GL + + G
Sbjct: 926 KAT----QVMTILNSLFVAYDEELHN--FPAITKMKTIGHIYMCCGGLFSDSSVNSG--- 976
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
+ +YA +L E Q V++ F+I G
Sbjct: 977 -QVVVEYATKLLEIAQKVSKDLGISFQITCG 1006
>UniRef50_A2FB45 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1552
Score = 70.5 bits (165), Expect = 1e-10
Identities = 33/83 (39%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ G+N G P+VAGVIG KP ++I G A+N A M+S G+ + +++ VY+++ +
Sbjct: 1470 RIRVGVNTGGPIVAGVIGTEKPTFEILGPAINTAHEMESHGVPMKVHISRPVYELIYGQQ 1529
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ + RG ++VK KG M TY +E
Sbjct: 1530 FNIIERGEIEVK-KGKMFTYIVE 1551
>UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1579
Score = 70.5 bits (165), Expect = 1e-10
Identities = 61/221 (27%), Positives = 103/221 (46%), Gaps = 42/221 (19%)
Query: 295 SVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGAT 354
S ++F I FSE+ L E + L+ + A FDE++ + P I KIK G
Sbjct: 1381 SASIIFIDIVKFSEYAASLTPQ----EIMGNLSTVFAAFDEMVKKYP--KITKIKLIGDV 1434
Query: 355 YMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATA 414
YMAA+GL + D H M ++ L +L VN +++
Sbjct: 1435 YMAAAGLFDEQDDPAS--HAKDMVNFGLDCLGELDEVN--------VKL----------- 1473
Query: 415 SSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTG 474
+A+ +R+ + GG L+ AG+ +G KP +DI G+ +N+A+R+ ST
Sbjct: 1474 -NASLEVRIGINTGGPLL-----AGV---------LGTDKPVFDIIGDPINIAARLQSTD 1518
Query: 475 LLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
+ IQ+++ + + + + RG V +KGKG +TY +
Sbjct: 1519 IAGRIQISKATKEYIENSNFNIEERGEVFLKGKGKQMTYLV 1559
>UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 464
Score = 70.1 bits (164), Expect = 2e-10
Identities = 32/84 (38%), Positives = 50/84 (59%), Gaps = 1/84 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GIN GPVVAGV+G +K +DIWG+ VN A R+ S + + V++ Y +L+ +
Sbjct: 379 QIRVGINTGPVVAGVVGLKKFSFDIWGDTVNTADRIQSGSVAGKVNVSESTY-LLTKDLF 437
Query: 495 KLRCRGTVDVKGKGNMVTYFLEGV 518
RG + K KG + YF+E +
Sbjct: 438 DFENRGKISAKNKGMIPMYFVENL 461
Score = 37.9 bits (84), Expect = 0.96
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 24/153 (15%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL NILPE A+ K F +L ++ VMF NF++F +
Sbjct: 257 LLLNILPEETAEEL----KKYG-FAKAKLQ----ENATVMFTDFVNFTKFSSSISSE--- 304
Query: 320 VECLRLLNEIIADFDEILAEEPFKY-IEKIKSTGATYMAASGLTNSTQDLVG-YRHVTAM 377
E + L+ +FD I KY +EKIK+ G +M+A G+T D+ R M
Sbjct: 305 -ELVSELDHCFRNFDAITT----KYRLEKIKTIGDAHMSACGVTGDGGDVADVIRAGIEM 359
Query: 378 ADYALR-LREQLQYVNEHSFNCFRIRIGKSCSP 409
D+ +E+ +++ E+ F+IR+G + P
Sbjct: 360 RDFVQSYAKEKPKHLQEY----FQIRVGINTGP 388
>UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 362
Score = 70.1 bits (164), Expect = 2e-10
Identities = 33/80 (41%), Positives = 50/80 (62%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G V+AGVIG +K YDIWG+ VN ASRM+S G + ++ + ++ ++
Sbjct: 261 GINSGEVIAGVIGRKKFAYDIWGDTVNSASRMESNGEAGKVNISGSTHALVKDL-FECEH 319
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
RG ++ KGKG + YF+ G+
Sbjct: 320 RGKINAKGKGEVDMYFVLGI 339
>UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1111
Score = 70.1 bits (164), Expect = 2e-10
Identities = 37/82 (45%), Positives = 51/82 (62%), Gaps = 1/82 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS-ARGYKLR 497
G+N G VVAGV+G P++ ++G+AVN ASRM+S G I V+ E +L G+
Sbjct: 994 GMNCGSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTE 1053
Query: 498 CRGTVDVKGKGNMVTYFLEGVG 519
RG V +KGKG M T++L G G
Sbjct: 1054 SRGEVIIKGKGVMETFWLTGQG 1075
>UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=5;
Pleocyemata|Rep: Guanylate cyclase PcGC-M2 precursor -
Procambarus clarkii (Red swamp crayfish)
Length = 1423
Score = 70.1 bits (164), Expect = 2e-10
Identities = 36/94 (38%), Positives = 60/94 (63%), Gaps = 4/94 (4%)
Query: 423 VRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVT 482
+R P L++R G++ GPV+AGV+G P+Y ++G+ VN ASRM+S G I ++
Sbjct: 1083 IRHRPEKKLLLR---IGLHTGPVIAGVVGLTMPRYCLFGDTVNTASRMESNGEPLRIHIS 1139
Query: 483 QEVYDIL-SARGYKLRCRGTVDVKGKGNMVTYFL 515
++ + L + GY + RG V +KGKG ++T++L
Sbjct: 1140 EQCHIALKNLGGYVMEPRGLVTMKGKGEVLTFWL 1173
>UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1292
Score = 70.1 bits (164), Expect = 2e-10
Identities = 34/80 (42%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG-YKLR 497
G++ GP VAGV+G + P+Y ++G+ VN ASRM+S G I ++ +L G +++
Sbjct: 1110 GLHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGEPLKIHISHTTKTLLDTFGTFEVT 1169
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG V +KGKG M+TY+L G
Sbjct: 1170 ERGLVPMKGKGEMLTYWLNG 1189
>UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic peptide
receptor A - Strongylocentrotus purpuratus
Length = 1008
Score = 69.7 bits (163), Expect = 3e-10
Identities = 39/97 (40%), Positives = 61/97 (62%), Gaps = 4/97 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T R+ P L +R GI+ GP VAGV+G + P+Y ++G+ VN ASRM+STG I
Sbjct: 910 TFRISHRPEEKLKLR---VGIHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESTGEAMKI 966
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFL 515
++++ IL + ++ RG V++KGKG+ +TY+L
Sbjct: 967 HLSEKTKLILEEFQCFQTILRGRVELKGKGSYLTYWL 1003
>UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 366
Score = 69.7 bits (163), Expect = 3e-10
Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 1/86 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGV+G +K YDIWG++VN ASRM+S+G+ + ++QE ++ + +
Sbjct: 257 GIHSGSVVAGVVGTKKFAYDIWGDSVNTASRMESSGIPGEVNISQETFEKIK-DFFICDY 315
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPD 524
RG + K KG + Y ++ + + + D
Sbjct: 316 RGKIKAKNKGEIDMYLVKKIREGLHD 341
>UniRef50_Q9UDB0 Cluster: Type VI adenylyl cyclase; n=12;
Euteleostomi|Rep: Type VI adenylyl cyclase - Homo
sapiens (Human)
Length = 64
Score = 69.7 bits (163), Expect = 3e-10
Identities = 30/52 (57%), Positives = 41/52 (78%)
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
ASGL ST D VG H+TA+ADYA+RL EQ++++NEHSFN F+++IG + P
Sbjct: 1 ASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGP 52
Score = 38.7 bits (86), Expect = 0.55
Identities = 16/18 (88%), Positives = 18/18 (100%)
Query: 439 GINIGPVVAGVIGARKPQ 456
G+N+GPVVAGVIGARKPQ
Sbjct: 47 GLNMGPVVAGVIGARKPQ 64
>UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precursor;
n=41; Euteleostomi|Rep: Heat-stable enterotoxin receptor
precursor - Homo sapiens (Human)
Length = 1073
Score = 69.7 bits (163), Expect = 3e-10
Identities = 39/98 (39%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR--GYKL 496
G++ GP AGV+G + P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 922 GVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLY 981
Query: 497 RCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPST 534
RG +KG+GN TY+L G + D +N P P T
Sbjct: 982 EVRGETYLKGRGNETTYWLTG----MKDQKFNLPTPPT 1015
>UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7;
Endopterygota|Rep: CG3216-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1141
Score = 69.3 bits (162), Expect = 3e-10
Identities = 34/87 (39%), Positives = 53/87 (60%), Gaps = 1/87 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG- 493
++ G++ G V AGV+G + P Y ++G+ VN ASRM+STG I V+ IL G
Sbjct: 1028 QIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGT 1087
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEGVGD 520
+++ RG V++KGKG + TY+L +
Sbjct: 1088 FQMEQRGDVELKGKGTVTTYWLNSTSE 1114
Score = 40.7 bits (91), Expect = 0.14
Identities = 43/161 (26%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 245 EEKEDMEHLQAYN-RKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
EEK L+ +LL ILP VAQ + D + E+ SV + F+ I
Sbjct: 890 EEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDL---------VEPEEFSSVTIYFSDI 940
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTN 363
F+ EL + ++ + LN++ + FD I+ F + K+++ G Y+ SGL
Sbjct: 941 VGFT----ELCARSSPMDVVNFLNDLYSTFDRIIG---FYDVYKVETIGDAYLVVSGLPE 993
Query: 364 STQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
D R + MA LR ++ + +IRIG
Sbjct: 994 PNGDKHA-REIALMALDILRAVSSFNLRHKPEYK-IQIRIG 1032
>UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Dechloromonas aromatica RCB|Rep: Adenylyl
cyclase class-3/4/guanylyl cyclase - Dechloromonas
aromatica (strain RCB)
Length = 431
Score = 68.9 bits (161), Expect = 5e-10
Identities = 38/85 (44%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V GI GPVVAGV+G +K YD+WG+ VN+ASR+ S G IQ+ Y L+ +
Sbjct: 338 VRIGIGTGPVVAGVVGKKKFIYDLWGDTVNLASRITSEGTPGMIQLDATTYHRLAGH-FA 396
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGD 520
T+ +KGKGN V Y L G+ D
Sbjct: 397 FDEPQTLHLKGKGNTVVYRLIGLQD 421
Score = 47.6 bits (108), Expect = 0.001
Identities = 48/151 (31%), Positives = 74/151 (49%), Gaps = 23/151 (15%)
Query: 240 KLQANEEKED--MEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC 297
K QA+ E+ ++ Q + +LL NILP +A+ + D+Q + D V
Sbjct: 196 KTQASLEETHRLLQDEQERSERLLLNILPGPIAERL--------KHDSQAIADGFAD-VT 246
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
VMF I NF+ EG + +LN I + FDE LAE+ +EKIK+ G YM
Sbjct: 247 VMFVDIVNFTRI---AEGMTPQ-QVFAMLNRIFSSFDE-LAEQ--YGMEKIKTIGDAYMV 299
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQL 388
A GL N + + ++A+ A+ +R+ L
Sbjct: 300 AGGLNNELNN-----YTQSIAELAIAMRDLL 325
>UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein daf-11 - Caenorhabditis elegans
Length = 1093
Score = 68.9 bits (161), Expect = 5e-10
Identities = 36/82 (43%), Positives = 52/82 (63%), Gaps = 2/82 (2%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G N GPV AGVIG + P+Y +G AV +AS+M+S+G+ D IQ+T +L + C
Sbjct: 879 GFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEENFPQFVC 938
Query: 499 --RGTVDVKGKGNMVTYFLEGV 518
RG ++G G ++TY+LEGV
Sbjct: 939 SNRGGRTIEGIGRILTYWLEGV 960
>UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1572
Score = 68.9 bits (161), Expect = 5e-10
Identities = 31/81 (38%), Positives = 52/81 (64%), Gaps = 1/81 (1%)
Query: 436 VPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
V G+N G P++ GV+G+ KP +DI G+ +NVA+R+ ST + IQ+++ ++ Y
Sbjct: 1469 VRIGVNSGGPLIGGVLGSDKPTFDIIGDTINVAARLQSTDIPGRIQISEGTKSLIDGLDY 1528
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
+ RG + +KGKGN T+F+
Sbjct: 1529 IIEERGEIFLKGKGNRKTFFV 1549
Score = 37.9 bits (84), Expect = 0.96
Identities = 40/170 (23%), Positives = 72/170 (42%), Gaps = 16/170 (9%)
Query: 235 LDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCD 294
L F + + E+++ + +A + KLL ILP+ + + +I
Sbjct: 1319 LSFTNESEVIEKRKAADIAKAKSEKLLYQILPKDIVVRLNRGETDISF---------TIP 1369
Query: 295 SVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGAT 354
S + F I FS + L + E + L+ + A FD+ +++ + I KIK G
Sbjct: 1370 SATIFFIDIVKFSVYASSLTPS----EIMTNLSTVFAAFDQNVSK--YDLITKIKLIGDV 1423
Query: 355 YMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
YMAA+GL +D +H L + + +N + + +RIG
Sbjct: 1424 YMAAAGLFQGEED-DPTKHADQSIKCCLDCIKSMDEINSNLESSIEVRIG 1472
>UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1417
Score = 68.5 bits (160), Expect = 6e-10
Identities = 34/80 (42%), Positives = 51/80 (63%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG-YKLR 497
G++ G VAGV+G + P+Y ++G+ VN ASRM+S G I +++ + L G +
Sbjct: 1051 GLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTT 1110
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG V +KGKG M+TY+LEG
Sbjct: 1111 RRGFVPMKGKGEMLTYWLEG 1130
>UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25;
n=2; Caenorhabditis|Rep: Putative uncharacterized protein
gcy-25 - Caenorhabditis elegans
Length = 1044
Score = 68.1 bits (159), Expect = 8e-10
Identities = 39/103 (37%), Positives = 60/103 (58%), Gaps = 5/103 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T +VR P L ++ GI G V AG++G+ P++ I+G+ VN+A RM STG I
Sbjct: 913 TFKVRHRPSHTL---QIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSI 969
Query: 480 QVTQEVYDILSAR--GYKLRCRGTVDVKGKGNMVTYFLEGVGD 520
Q+++ + L + + L RG +DVKGKG +T++L G D
Sbjct: 970 QLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEKD 1012
>UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=12; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1567
Score = 68.1 bits (159), Expect = 8e-10
Identities = 27/74 (36%), Positives = 50/74 (67%)
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTV 502
GP++ GV+G KP +DI G+ +NVA+R+ ST + ++Q++ +++ + + RG +
Sbjct: 1475 GPLIGGVLGTDKPTFDIIGDPINVAARLQSTDIPGNVQISGNTKELIQNLDFVIEERGEI 1534
Query: 503 DVKGKGNMVTYFLE 516
+KGKGN +TYF++
Sbjct: 1535 YLKGKGNRMTYFVK 1548
Score = 38.3 bits (85), Expect = 0.73
Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 15/122 (12%)
Query: 240 KLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVM 299
+L+ +++++ E +A + KLL ILP+++ + +I +S +
Sbjct: 1323 ELEEIQKRKEAEEAKAKSEKLLYQILPKNIVVRLNGGETDIS---------FTINSATIF 1373
Query: 300 FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAAS 359
F I FS + L + E + L+ + A FD I+++ + I KIK G YMAA+
Sbjct: 1374 FIDIVKFSNYASLLTPS----EIMSNLSLVFATFDSIVSK--YTTITKIKLIGDVYMAAA 1427
Query: 360 GL 361
GL
Sbjct: 1428 GL 1429
>UniRef50_A2F7J9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1257
Score = 68.1 bits (159), Expect = 8e-10
Identities = 30/76 (39%), Positives = 49/76 (64%), Gaps = 1/76 (1%)
Query: 439 GINI-GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR 497
G+N GP+++GV+G KP +D+WG+AVNV++R++++ +D IQ+ + Y L Y
Sbjct: 1170 GVNYDGPIISGVLGREKPLFDVWGDAVNVSARLETSSYIDTIQMLPQTYHTLPEGYYNAF 1229
Query: 498 CRGTVDVKGKGNMVTY 513
R V +KGKG T+
Sbjct: 1230 ERNDVFLKGKGTTNTF 1245
Score = 41.9 bits (94), Expect = 0.059
Identities = 36/138 (26%), Positives = 59/138 (42%), Gaps = 13/138 (9%)
Query: 230 ESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELY 289
E TY + N + +++ QA LL I+P+ +A + D
Sbjct: 1012 EMTYAFILRDITEFNRSESELKGAQARVENLLTKIMPKVIATRLMSKSDREDIISC---- 1067
Query: 290 HEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIK 349
D ++F I +F + N+E + ++LL+ I + FD +A+ P + KIK
Sbjct: 1068 ---VDKAVIIFIGIHDFVSWCTNK--NHEDI--MQLLDVIFSKFDRKIAKYPT--LVKIK 1118
Query: 350 STGATYMAASGLTNSTQD 367
YMAA+GL N D
Sbjct: 1119 MINGVYMAAAGLFNEVSD 1136
>UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 642
Score = 67.7 bits (158), Expect = 1e-09
Identities = 30/80 (37%), Positives = 49/80 (61%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G ++AGVIG K YD+WG+ VN ASRM+S+G + + ++ Y+++ ++
Sbjct: 528 GINTGKLIAGVIGKNKFAYDVWGDTVNTASRMESSGEIGRVNISGVTYELVK-DFFECEY 586
Query: 499 RGTVDVKGKGNMVTYFLEGV 518
RG + K KG + YF+ +
Sbjct: 587 RGKIMAKNKGAIDMYFVNSI 606
Score = 37.1 bits (82), Expect = 1.7
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 16/116 (13%)
Query: 246 EKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPN 305
+ E ++ Q + LL NILPE VA K A+ +HE V V+F
Sbjct: 387 QNETIKQEQQISDALLLNILPEQVANELKEHGK------AKIRHHEM---VSVLFTDFKG 437
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
F++ + E ++ L + FDEI+ + +EKIK+ G YMA GL
Sbjct: 438 FTKLAETMPPQ----ELVQELEKCFTLFDEIMEKHN---LEKIKTIGDAYMAVGGL 486
>UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1564
Score = 67.7 bits (158), Expect = 1e-09
Identities = 32/76 (42%), Positives = 49/76 (64%), Gaps = 1/76 (1%)
Query: 439 GINI-GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR 497
G+N GPV+AGV+G+ KP +DI G+ +NVA+R+ STG + + V+Q Y++L + +
Sbjct: 1473 GVNSSGPVIAGVLGSDKPLFDIIGDPINVAARLQSTGSPNQVHVSQATYELLKDTDFYIS 1532
Query: 498 CRGTVDVKGKGNMVTY 513
G +KGKG TY
Sbjct: 1533 KVGDTFLKGKGVQTTY 1548
Score = 37.9 bits (84), Expect = 0.96
Identities = 39/164 (23%), Positives = 71/164 (43%), Gaps = 17/164 (10%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
+ K++ E +A + KLL I+P + + +I F ++F I
Sbjct: 1331 DRKKEAEIEKAKSEKLLYQIMPRDIVVRINNGESDIS-FSVP--------FATIIFIDIN 1381
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
FSE+ N + + L+ A+ D I ++ ++ + KIK G YMAA GL +
Sbjct: 1382 KFSEY----SSNLSPQDIMSNLSFYFAEIDRIASK--YEMLNKIKLIGDIYMAACGLFHP 1435
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCS 408
+ + H +AL + +++ +N + IRIG + S
Sbjct: 1436 NIEPI--HHAEDTIKFALEVVDEIDNINRCLESHLSIRIGVNSS 1477
>UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=6; cellular organisms|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1529
Score = 67.7 bits (158), Expect = 1e-09
Identities = 30/83 (36%), Positives = 56/83 (67%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
RV G++IG P+VAGVIG KP ++I+G A+++A +M+ G+ + V++ +Y+++
Sbjct: 1446 RVRVGVHIGGPIVAGVIGTGKPTFEIFGPAISMAQQMEHNGVPMKVHVSRSIYELIYGGT 1505
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
YK+ RG + +K +G +TY ++
Sbjct: 1506 YKIEERGEIQIK-QGKALTYLVD 1527
Score = 46.8 bits (106), Expect = 0.002
Identities = 42/151 (27%), Positives = 67/151 (44%), Gaps = 17/151 (11%)
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+A + +LLA+ILP + +KNI F S ++F I F+ +
Sbjct: 1317 RAKSDRLLASILPATLVPRVQAGEKNIS-FSVP--------SATIVFIDIVEFTPWC--- 1364
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRH 373
+N LN+I +FD I+ P +E+IK G YMAA G+ T +++ +
Sbjct: 1365 -SSNTAQVVTGTLNDIFTEFDTIIESLPV--MERIKCIGDCYMAAGGIFAETPNVLQF-- 1419
Query: 374 VTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
A D+ L + VNE R+R+G
Sbjct: 1420 ARAAVDFGLDAIAAIGRVNEKHGMSLRVRVG 1450
>UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 629
Score = 67.3 bits (157), Expect = 1e-09
Identities = 38/94 (40%), Positives = 57/94 (60%), Gaps = 4/94 (4%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
+V GI+ G VVAGV+G +KP+Y ++GN VN+ SR ++TGL I V++ Y L + +
Sbjct: 524 QVTIGIHSGEVVAGVVGQKKPRYCLFGNTVNLTSRTETTGLKGKINVSEYAYRCLLVQPH 583
Query: 495 K---LRCRGTVDVKGKGN-MVTYFLEGVGDSIPD 524
+ + RG V +KGK M+TY L+ PD
Sbjct: 584 EQFVFKKRGPVVMKGKKEPMITYILQRNDKYQPD 617
Score = 48.4 bits (110), Expect = 7e-04
Identities = 40/148 (27%), Positives = 76/148 (51%), Gaps = 19/148 (12%)
Query: 218 ATVALLLHSQQTESTYRLDFIWKL---QANEEKEDMEHLQAYNRKLLANILPEHVAQHF- 273
AT L+L S+Q + ++L ++ + + ++E+ Q N +LL +ILP VA
Sbjct: 359 ATRDLILLSEQHNAEFKLSQRLEILTDKLQQTSRELENEQQLNDRLLYSILPASVANDLR 418
Query: 274 LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 333
L N ++++ V +MF+ I +F+ + +++ E +E + +LNE+ +F
Sbjct: 419 LRKPVNANKYEI----------VTIMFSGIVDFTNYCNKIK---EPMEIVEMLNEVYTEF 465
Query: 334 DEILAEEPFKYIEKIKSTGATYMAASGL 361
D++ Y K+++ G YMA SGL
Sbjct: 466 DQLTDSNDDIY--KVETVGDKYMAVSGL 491
>UniRef50_A2DWV8 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1580
Score = 67.3 bits (157), Expect = 1e-09
Identities = 31/84 (36%), Positives = 55/84 (65%), Gaps = 2/84 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ AGIN G P++AGV+G KP +DI G+A++VA+ M+ G+ ++ + Q +YD++ +
Sbjct: 1492 RIRAGINCGGPIIAGVLGIEKPTFDILGSAISVAASMEHNGVPMNVHIPQHMYDLVYDQE 1551
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEG 517
+ + RG + +K K + TY + G
Sbjct: 1552 FVFKERGDIQIKDK-MIHTYLVSG 1574
>UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2;
Caenorhabditis|Rep: Guanylate cyclase - Caenorhabditis
elegans
Length = 1012
Score = 66.9 bits (156), Expect = 2e-09
Identities = 33/82 (40%), Positives = 51/82 (62%), Gaps = 2/82 (2%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--ARG 493
+ G++ GPVV GV+G P+Y ++G++VN ASRM+S G + ++ E L+ G
Sbjct: 916 IRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEVIGG 975
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
Y+ RG V VKGKG + T++L
Sbjct: 976 YQTEPRGEVIVKGKGAVQTHWL 997
>UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1151
Score = 66.9 bits (156), Expect = 2e-09
Identities = 34/86 (39%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA--RGYKL 496
G + GP VAGV+G P+Y ++G++VN ASRM+S G + ++ L++ GY
Sbjct: 1049 GFHSGPAVAGVVGLTMPRYCLFGDSVNTASRMESNGKAGRVHISSSANHFLTSVIGGYVT 1108
Query: 497 RCRGTVDVKGKGNMVTYFLEG-VGDS 521
RG V +KGKG M T++L G +G++
Sbjct: 1109 EPRGEVIIKGKGVMETFWLLGRIGEA 1134
>UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_172, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2514
Score = 66.9 bits (156), Expect = 2e-09
Identities = 32/80 (40%), Positives = 50/80 (62%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G++ G V+AGVIG KPQ+ + G+ VN SR+ STG I+++++ Y ++S
Sbjct: 1841 VKIGVHYGNVIAGVIGYHKPQFSLIGDTVNTTSRVCSTGQDGQIKISEDAYKLVSGSQDF 1900
Query: 496 LRCRGTVDVKGKGNMVTYFL 515
+ + V+ KGKG +VTY L
Sbjct: 1901 IFTKDFVEAKGKGVLVTYIL 1920
Score = 42.7 bits (96), Expect = 0.034
Identities = 19/51 (37%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GI+ G ++ GV+G +YDI+G V +A++M+S G ++QV+ +IL
Sbjct: 2413 GIHTGNIIGGVLGTEIVRYDIYGPDVLIANKMESKGERGNLQVSSTTKEIL 2463
Score = 34.7 bits (76), Expect = 9.0
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
+FD QE E V ++F I F + ++ E V + LL+ + +D + ++
Sbjct: 1735 EFDIQENQGE----VAILFCDICQFDKI---IKAEKENV--IHLLDILFRQYDSLCSQYG 1785
Query: 342 FKYIEKIKSTGATYMAASGLTN 363
++KI++ G TYMAA+GL N
Sbjct: 1786 ---LQKIETVGKTYMAAAGLKN 1804
>UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2815
Score = 66.5 bits (155), Expect = 2e-09
Identities = 61/218 (27%), Positives = 106/218 (48%), Gaps = 39/218 (17%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E+ D V ++F I NF + NE + +++L+++ FD + ++KI++
Sbjct: 1903 EKQDEVIIVFCDICNFDDIIF-----NEKINTVKILDKLYRQFDLACQQNG---LQKIET 1954
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPS 410
G TY+AA+G+++ + L + ++ + LQ+ +F+ RI K
Sbjct: 1955 VGKTYLAAAGISDVEKLLKAEGRLQDVSP----AKRALQF----AFDLQRIVKSKQL--- 2003
Query: 411 DATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRM 470
AS+ ++V + G P ++GVIG KPQ+ + G+ VN SR+
Sbjct: 2004 -YLASNKKIIIKVGIHLG---------------PAISGVIGYHKPQFSLIGDTVNTTSRV 2047
Query: 471 DSTGLLDHIQVTQEVYD-ILSARGYKLRCRGTVDVKGK 507
STGL DHI +++EVYD + YK + R DV+ K
Sbjct: 2048 CSTGLSDHIIISKEVYDKVYQLSQYKFQQR---DVEAK 2082
Score = 41.5 bits (93), Expect = 0.078
Identities = 16/51 (31%), Positives = 31/51 (60%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G + G++G +YDI+G V +A++M+S G H+ V++ +L
Sbjct: 2737 GVHTGKLYGGIVGTEIVRYDIYGQDVIIANKMESNGESGHVMVSETTKKLL 2787
Score = 35.9 bits (79), Expect = 3.9
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 13/107 (12%)
Query: 260 LLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEG 319
LL N+LP H+ FL S K +EL+ V ++FA I F+++ +
Sbjct: 2607 LLKNLLPAHILDTFLNSMKKEIPLICEELH-----DVTLLFADIAGFTKY----SSTTDP 2657
Query: 320 VECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQ 366
+ + +L + DFD+ + + K+ + G Y+ GLTN +
Sbjct: 2658 IVVVNMLRRLFTDFDDHCLNQ---NVYKLYTIGDCYV-CFGLTNKNE 2700
>UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2;
Sinorhizobium|Rep: Putative regulatory protein -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 520
Score = 66.5 bits (155), Expect = 2e-09
Identities = 35/82 (42%), Positives = 53/82 (64%), Gaps = 3/82 (3%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG- 493
RV GI+ GPVVAG+IG + YD+WG VN+ASR++S G+ D IQ+++ L RG
Sbjct: 440 RVRIGIHTGPVVAGLIGRLRFVYDVWGETVNIASRLESQGVADVIQISEATRRAL--RGP 497
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
+ L R ++++G G + TY +
Sbjct: 498 WTLERRCALELRGIGAVETYLV 519
Score = 45.6 bits (103), Expect = 0.005
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 13/126 (10%)
Query: 284 DAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFK 343
D +E+ ++ D V ++FA I FS L + + +R L+ + FD +L E+
Sbjct: 337 DGEEIIADRFDEVSILFADIVGFSPIAASLTAS----DLVRRLDRMFRRFD-LLTEQ--H 389
Query: 344 YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRI 403
+EKIK+ G YMAA G+ D + A+ LR + + E + FR+RI
Sbjct: 390 RVEKIKTIGDAYMAACGIPEPAPDHAD--RIVALGKSMLRSLQDM----EAGPDRFRVRI 443
Query: 404 GKSCSP 409
G P
Sbjct: 444 GIHTGP 449
>UniRef50_A7BYP5 Cluster: Adenylate/guanylate cyclase; n=1;
Beggiatoa sp. PS|Rep: Adenylate/guanylate cyclase -
Beggiatoa sp. PS
Length = 132
Score = 66.5 bits (155), Expect = 2e-09
Identities = 31/82 (37%), Positives = 53/82 (64%), Gaps = 1/82 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G VV GV+G +K YD++G+++N ASRM+S I +++ Y ++ + +
Sbjct: 51 QIRIGIHTGKVVGGVVGVKKYIYDVFGDSINTASRMESNSQPMKINISETTYQLVKDK-F 109
Query: 495 KLRCRGTVDVKGKGNMVTYFLE 516
K+ RG + VKGKG M YF++
Sbjct: 110 KVIERGPLFVKGKGEMNMYFID 131
>UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1;
Plesiocystis pacifica SIR-1|Rep: Adenylate or guanylate
cyclase - Plesiocystis pacifica SIR-1
Length = 601
Score = 66.5 bits (155), Expect = 2e-09
Identities = 32/90 (35%), Positives = 52/90 (57%), Gaps = 1/90 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
V G++ GP++AG+IG K YD+WG VN A+RM+S+ D I V+ + ++A +
Sbjct: 496 VRVGLHSGPLIAGIIGRAKLAYDVWGETVNTAARMESSSAADRINVSAPTHAQIAAY-FV 554
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGDSIPDD 525
RG V+ KG G + +F+E + + D
Sbjct: 555 TTPRGPVEAKGLGPVDMFFVERIAPAYAAD 584
>UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1;
Microscilla marina ATCC 23134|Rep: Adenylate or
guanylate cyclase - Microscilla marina ATCC 23134
Length = 774
Score = 66.5 bits (155), Expect = 2e-09
Identities = 29/78 (37%), Positives = 49/78 (62%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGV+G K YD+WG+ VN+A+RM+S+G + ++ Y ++ + ++
Sbjct: 695 GIHTGEVVAGVVGKNKFAYDVWGDTVNLAARMESSGAPGMVNISGHTYQLIKDQ-FETTY 753
Query: 499 RGTVDVKGKGNMVTYFLE 516
RG + K KG + YF++
Sbjct: 754 RGKIKAKNKGEVDMYFVK 771
>UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 1213
Score = 66.1 bits (154), Expect = 3e-09
Identities = 32/79 (40%), Positives = 50/79 (63%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G V+AGVIG KPQ+ + G+ VN ASR+ STG + I ++++ YD + Y
Sbjct: 340 KIKIGIHYGRVIAGVIGCHKPQFSLIGDTVNTASRVCSTGDVGQITLSEQAYDEIKQIPY 399
Query: 495 KLRCRGTVDVKGKGNMVTY 513
+ + V KGKG++ TY
Sbjct: 400 IIFQKKRVYAKGKGDINTY 418
Score = 39.1 bits (87), Expect = 0.42
Identities = 17/51 (33%), Positives = 31/51 (60%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G + GVIG +YDI+G V +A++M+S G + V++ ++L
Sbjct: 1128 GVHTGSYIGGVIGTDIVRYDIYGPDVMIANKMESNGEQGKVMVSKTTMNLL 1178
Score = 36.7 bits (81), Expect = 2.2
Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 247 KEDMEHLQAYNRKLLANILPEHVAQHFLCS-DKNIDQFDAQELYHEQCDSVCVMFASIPN 305
++ +E +L +LPEH+ FL + +K ID D Q D+V +FA I
Sbjct: 984 RQTLESRAKKQNDILMYLLPEHILSKFLNNPNKKIDLID-------QLDNVTFLFADIAG 1036
Query: 306 FSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNST 365
F+++ ++ N V LR+L F+E + K + KI + G Y+ G N++
Sbjct: 1037 FTKYSGSVQPENV-VNMLRIL------FNEFDQQCQKKNLYKIYTIGDCYVVI-GTKNAS 1088
Query: 366 QDLVGYRHVTAMADYALRLREQLQYVNE-HSFNCFRIRIG 404
L + + + + E ++ V F +RIG
Sbjct: 1089 NRLRPHEEAKNVVELGFEMIEIIKKVRSIVQFEELEMRIG 1128
>UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1113
Score = 66.1 bits (154), Expect = 3e-09
Identities = 38/94 (40%), Positives = 56/94 (59%), Gaps = 3/94 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG--YKL 496
G + G V AGV+G P+Y ++G+ VNV+SRM+STG IQ+++E + + A +
Sbjct: 1016 GFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTT 1075
Query: 497 RCRGTVDVKGKGNMVTYFLEG-VGDSIPDDIYNN 529
RG V VKGKG T++LE VGD+ + N
Sbjct: 1076 TERGEVQVKGKGTCRTFWLEDRVGDASTTNYIQN 1109
>UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1576
Score = 66.1 bits (154), Expect = 3e-09
Identities = 26/73 (35%), Positives = 48/73 (65%)
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTV 502
GP++ GV+G KP +DI G+ +NVA+R+ ST + ++Q++ +++ + + RG +
Sbjct: 1483 GPLIGGVLGTDKPTFDIIGDTINVAARLQSTDIPGNVQISASTKEMIEHLDFVIEERGLI 1542
Query: 503 DVKGKGNMVTYFL 515
+KGKG +TYF+
Sbjct: 1543 YLKGKGKQMTYFV 1555
Score = 42.7 bits (96), Expect = 0.034
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 18/193 (9%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANE--EKEDMEHLQAYNRKLLANILPEHVAQ 271
+ G T+ + ++ + L FI + + + +K+ E +A + KLL ILP+ +
Sbjct: 1302 VPFGITIIGMKENEGSADITSLVFILENEEEKIKQKKLAEESKAKSEKLLYQILPKDIVV 1361
Query: 272 HFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 331
+ +I S + F I FS Y EL +E + L L + A
Sbjct: 1362 RLNRGETDISF---------TIPSATIFFIDIVKFSS-YAELLTPSEIMANLSL---VFA 1408
Query: 332 DFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYV 391
FD I++E F+ I KIK G YMAA+GL ++ +H L+ + ++ +
Sbjct: 1409 TFDGIVSE--FQSITKIKLIGDVYMAAAGLFQDPKE-ESKQHAEDAVRCCLKCAKSMEEI 1465
Query: 392 NEHSFNCFRIRIG 404
N +RIG
Sbjct: 1466 NMKLNASLEVRIG 1478
>UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_24, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2488
Score = 66.1 bits (154), Expect = 3e-09
Identities = 39/106 (36%), Positives = 62/106 (58%), Gaps = 8/106 (7%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G V+AGVIGA KPQ+ + G+ VN SR+ ST I ++Q+ Y+ +S + Y+ +
Sbjct: 1671 GIHYGRVIAGVIGAHKPQFSLIGDTVNTTSRVCSTSEPGIITLSQQAYEKVSNKKYQFKL 1730
Query: 499 RGTVDVKGKGNMVTY-FLEG------VGDSIPDDIYNNPIPSTSSE 537
R V+ KGKG + TY F++ V + DD+ +P P ++
Sbjct: 1731 R-EVEAKGKGTIKTYQFIKSNKKQQQVILKVADDVSKSPNPHLQNQ 1775
Score = 42.3 bits (95), Expect = 0.045
Identities = 19/53 (35%), Positives = 31/53 (58%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSA 491
G + G V+ GV+G +YDI+G V A++M+S G I V+Q D++ +
Sbjct: 2397 GAHTGRVIGGVVGTDVVRYDIYGEDVTTANKMESKGQEGKIMVSQATKDLIES 2449
Score = 35.5 bits (78), Expect = 5.1
Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 9/114 (7%)
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
E V ++F I +F + NE ++ + L+ + FD+ ++KI++
Sbjct: 1567 EDQGDVAILFCDIYDFDDII-----RNEQIKVVEFLDNLYRQFDQFCQANE---LQKIET 1618
Query: 351 TGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
G TYMAA GL + + D AL+++E ++ + ++IG
Sbjct: 1619 VGKTYMAAGGLKDYNMS-DNLNPTERILDAALQMQESVKTMKYGDKKAVILKIG 1671
Score = 35.5 bits (78), Expect = 5.1
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 15/155 (9%)
Query: 251 EHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFY 310
E A ++L +LP+H+ F +D I D E C ++FA I F+++
Sbjct: 2257 ESKNAKQTQILQYLLPQHIIGRFFSTD--ITTTDNFTDVFENC---TILFADIAGFTKYS 2311
Query: 311 VELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG 370
+E + V LR+L FDE A + F+ + K+ + G Y+ + + +D VG
Sbjct: 2312 SSVE-PEQVVNMLRIL---FQQFDE--ACQKFQ-VYKLYTIGDCYVCMGIIDANNRDPVG 2364
Query: 371 YRHVTAMADYALRLREQLQYVN-EHSFNCFRIRIG 404
+ + L++ + +Q +N + F +RIG
Sbjct: 2365 --EAINVVLFGLKMIQIIQQINKDPQFQHLNMRIG 2397
>UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to
ENSANGP00000009149; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1319
Score = 65.7 bits (153), Expect = 4e-09
Identities = 32/78 (41%), Positives = 49/78 (62%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR-GYKLR 497
GI+ G V+GV+G P+Y ++G+ VN ASRM+S G I + E ++L G+ +
Sbjct: 1060 GIHSGSTVSGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHTSSETKNLLEQMGGFVVE 1119
Query: 498 CRGTVDVKGKGNMVTYFL 515
RG + +KGKG +VTY+L
Sbjct: 1120 ERGLISMKGKGQLVTYWL 1137
>UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1;
Jannaschia sp. CCS1|Rep: Adenylate/guanylate cyclase -
Jannaschia sp. (strain CCS1)
Length = 417
Score = 65.7 bits (153), Expect = 4e-09
Identities = 34/77 (44%), Positives = 46/77 (59%), Gaps = 1/77 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+++GPVVAGVIG RK YD+WG VN ASRM++ I +T L +
Sbjct: 338 GLHVGPVVAGVIGNRKLFYDVWGETVNTASRMETYSAPGRILITPAARAQL-GEDFMFEP 396
Query: 499 RGTVDVKGKGNMVTYFL 515
RG +DVKG G + T++L
Sbjct: 397 RGEIDVKGIGIVETWWL 413
Score = 43.2 bits (97), Expect = 0.026
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 20/173 (11%)
Query: 237 FIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSV 296
++ L A+ + +E A + LL ++LP +A + + + +V
Sbjct: 191 YVGFLNADTAERALEVEYARSEDLLYSLLPREIAGRL--------KAEPHTTIADSLPNV 242
Query: 297 CVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYM 356
++FA I NF+ L+ + LLN + +FD LA+ +EKIK+ G YM
Sbjct: 243 AIVFADIANFTPLSARLDPRR----VVDLLNGVFTEFDG-LADR--HQLEKIKTIGDAYM 295
Query: 357 AASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
A+G+ NS + +R AD AL + E + + F IRIG P
Sbjct: 296 VAAGMPNSCGN-PAHR----AADMALDMLEVARATSVALPEGFEIRIGLHVGP 343
>UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalytic
domain containing protein; n=1; Babesia bovis|Rep:
Adenylate and guanylate cyclase catalytic domain
containing protein - Babesia bovis
Length = 2446
Score = 65.7 bits (153), Expect = 4e-09
Identities = 83/312 (26%), Positives = 130/312 (41%), Gaps = 44/312 (14%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHF 273
IA+ VA + + E R +F+++ AN ++ +LL +LP V
Sbjct: 1524 IAINVFVAFV--GYRLEYNSRKNFLFEFSANNARKKQS-------ELLNTMLPTFVVTKM 1574
Query: 274 LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 333
+ + N D E+ V V+F + NF +E + LL+ + F
Sbjct: 1575 INARLNEDGIPIG-FEAEEHTLVSVVFCDVCNFQNLVATVEPTI----LVELLDSLFLAF 1629
Query: 334 DEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNE 393
D E F KI++ TY+AA GL+ + Y D AL + E + +
Sbjct: 1630 DR--CAEQFG-ATKIETVFETYLAALGLSRGNI-ICPYEAAANSIDMALAMIEVARSIRY 1685
Query: 394 HSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGAR 453
S D T + + V+V GIN G +++G++G +
Sbjct: 1686 TSMQ----------ERDDGTFAEQDDVAVVKV-------------GINSGKIISGLVGFK 1722
Query: 454 KPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLRCRGTVDVKGKGNMVT 512
KPQY ++G+ VN ASRM +TG +I ++ YD++ S R T VKGKG M T
Sbjct: 1723 KPQYALFGDTVNTASRMKTTGESGYIHISTSTYDLVKSDVTLHFEHRETF-VKGKGIMNT 1781
Query: 513 YFL-EGVGDSIP 523
+ L G S P
Sbjct: 1782 HLLISAEGSSYP 1793
Score = 42.7 bits (96), Expect = 0.034
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V GVIG+ + +YD+WG ++ A+ M+S G+ I +++ + IL
Sbjct: 2358 GLHYGHAVGGVIGSGRLRYDLWGMDIHTANAMESHGIPGKINISERLKLIL 2408
>UniRef50_A2FPM7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 713
Score = 65.7 bits (153), Expect = 4e-09
Identities = 28/82 (34%), Positives = 54/82 (65%), Gaps = 2/82 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
R+ G+N+G P+VAGV+G KP ++I+G + +A +M+ G+ + +++ VY+++
Sbjct: 631 RIRVGVNVGGPLVAGVLGTEKPTFEIFGPVIVMAQQMEHNGVPMKVHISRAVYELIYGGQ 690
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
YK+ RG + +K +G +VTY +
Sbjct: 691 YKIEERGEIQIK-QGRVVTYLV 711
>UniRef50_P16065 Cluster: Speract receptor precursor; n=7;
Euechinoidea|Rep: Speract receptor precursor -
Strongylocentrotus purpuratus (Purple sea urchin)
Length = 1125
Score = 65.7 bits (153), Expect = 4e-09
Identities = 35/80 (43%), Positives = 49/80 (61%), Gaps = 1/80 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARGYKLR 497
GI+ G VAGV+G P+Y ++G+ VN ASRM+S GL I V+ +L GY+L
Sbjct: 1012 GIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALRIHVSPWCKQVLDKLGGYELE 1071
Query: 498 CRGTVDVKGKGNMVTYFLEG 517
RG V + GKG + T++L G
Sbjct: 1072 DRGLVPMNGKGEIHTFWLLG 1091
Score = 36.7 bits (81), Expect = 2.2
Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 22/163 (13%)
Query: 244 NEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
+E ++++ + +LL +LP +A + K I + E + V + F+ I
Sbjct: 870 DERTQELQKEKTKTEQLLHRMLPPSIASQLI---KGI------AVLPETFEMVSIFFSDI 920
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTN 363
F+ L + ++ + LLN++ FD I++ + K+++ G YM SGL
Sbjct: 921 VGFTA----LSAASTPIQVVNLLNDLYTLFDAIISNYD---VYKVETIGDAYMLVSGLPL 973
Query: 364 STQDLVGYRHVTAMADYALRLREQLQ-YVNEHSFNCF-RIRIG 404
D RH +A A L E ++ ++ H F ++RIG
Sbjct: 974 RNGD----RHAGQIASTAHHLLESVKGFIVPHKPEVFLKLRIG 1012
>UniRef50_A2ES71 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1523
Score = 65.3 bits (152), Expect = 6e-09
Identities = 30/83 (36%), Positives = 55/83 (66%), Gaps = 2/83 (2%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
++ G+N G P+VAGV+G KP ++I G A+N+A +M+ G+ + V++ VY+++
Sbjct: 1438 QIRVGVNTGGPIVAGVLGTDKPTFEILGPAINMAQQMEHHGVPMKVHVSRAVYELIYGGP 1497
Query: 494 YKLRCRGTVDVKGKGNMVTYFLE 516
+ ++ RG V++K G +VTY +E
Sbjct: 1498 FDIKERGEVEIK-NGPVVTYLIE 1519
Score = 42.3 bits (95), Expect = 0.045
Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
++LA+ILP + +KNI+ F Q S+ V+F I +F+ + L +
Sbjct: 1314 RMLASILPPRLVVRVQAGEKNIN-FAVQ--------SITVVFMDIVSFTPWCGSLPAST- 1363
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMA 378
+ LN I ++D I A + KIK G YM A G+ H +
Sbjct: 1364 ---VMAALNRIFKEYDSICAMHTT--MTKIKCIGDCYMGAGGIFADVNQPA--LHAKDVV 1416
Query: 379 DYALRLREQLQYVNEHSFNCFRIRIG 404
++ L E L+ VNE +IR+G
Sbjct: 1417 EFGLECIEGLERVNEEINQKLQIRVG 1442
>UniRef50_UPI00006975C6 Cluster: Guanylyl CYclase family member
(gcy-27); n=1; Caenorhabditis elegans|Rep: Guanylyl
CYclase family member (gcy-27) - Caenorhabditis elegans
Length = 712
Score = 64.9 bits (151), Expect = 7e-09
Identities = 36/82 (43%), Positives = 49/82 (59%), Gaps = 1/82 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ-EVYDILSARG 493
RV G + GP+ AGVIG + P+Y ++G+ VN ASRM S IQ ++ +L+
Sbjct: 609 RVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATHE 668
Query: 494 YKLRCRGTVDVKGKGNMVTYFL 515
YKL RG V VKGKG + Y+L
Sbjct: 669 YKLVKRGIVHVKGKGEVNCYWL 690
Score = 44.0 bits (99), Expect = 0.015
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 9/82 (10%)
Query: 330 IADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLRE-QL 388
I DF IL P K +E +TG TYM ASG+ N + RHV +A+ +L +R L
Sbjct: 544 ICDFIVILKRRPPKEVE---TTGETYMVASGVPNENEG----RHVFEVAEMSLEIRAISL 596
Query: 389 QYVNEHSFNC-FRIRIGKSCSP 409
Y E+ N R+RIG P
Sbjct: 597 SYTLENDKNYKLRVRIGFHAGP 618
>UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon
nigroviridis|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 1001
Score = 64.9 bits (151), Expect = 7e-09
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
T ++R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 916 TFKIRHRPNDQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 972
Query: 480 QVTQEVYDILSARGY-KLRCRGTVDVKGK 507
V+ ++L GY L+ RG V++K +
Sbjct: 973 HVSSATKEVLDEFGYFDLQLRGDVEMKAR 1001
>UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1545
Score = 64.9 bits (151), Expect = 7e-09
Identities = 66/258 (25%), Positives = 116/258 (44%), Gaps = 54/258 (20%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
KLL +ILP + + +KNI F Q S V+F I +F+ + L N
Sbjct: 1339 KLLESILPAKLVRRVQQGEKNIS-FSVQ--------SASVVFMDIVSFTPWCGSLPANR- 1388
Query: 319 GVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL-TNSTQDLVGYRHVTAM 377
+ +LN + +FD +A F + KIK G YMAA G+ Q V H +
Sbjct: 1389 ---VMEILNRLYKEFDAKVAS--FPTMTKIKCIGDCYMAAGGIFAEINQPAV---HAKEI 1440
Query: 378 ADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVP 437
++ + + VNE + +IR+G + GG L+
Sbjct: 1441 VEFGIEAIGAVGVVNEETKQSLQIRVG--------------------INTGGPLV----- 1475
Query: 438 AGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR 497
AG+ +G+ KP ++I G +N+A +M+ G+ + +++ VY+++ +K++
Sbjct: 1476 AGV---------LGSGKPTFEILGPTINMAQQMEHHGVPMQVHISRAVYELIYGGNFKIK 1526
Query: 498 CRGTVDVKGKGNMVTYFL 515
RG +++K G +VTY +
Sbjct: 1527 ERGQIEIK-NGTVVTYLV 1543
>UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-34 -
Caenorhabditis elegans
Length = 686
Score = 64.9 bits (151), Expect = 7e-09
Identities = 29/78 (37%), Positives = 50/78 (64%), Gaps = 1/78 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG-YKLR 497
G++ G ++AGV+G + P+Y ++G V +AS+M+S G+ IQ + Y G ++
Sbjct: 551 GLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFS 610
Query: 498 CRGTVDVKGKGNMVTYFL 515
RG ++VKG+G++ TYFL
Sbjct: 611 PRGRINVKGRGDVETYFL 628
>UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1;
Flavobacteriales bacterium HTCC2170|Rep:
Adenylate/guanylate cyclase - Flavobacteriales bacterium
HTCC2170
Length = 394
Score = 64.5 bits (150), Expect = 1e-08
Identities = 29/82 (35%), Positives = 51/82 (62%), Gaps = 1/82 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G VVAGV+G +K YD++G+ +N ASR++ G + I ++ Y+ + +
Sbjct: 314 KMRVGIHSGTVVAGVVGKKKFAYDLFGDTINTASRIEFAGEVGKINISSSTYEQIK-NDF 372
Query: 495 KLRCRGTVDVKGKGNMVTYFLE 516
K RG + KGKG++ YF++
Sbjct: 373 KCLSRGKIFAKGKGDLEMYFVK 394
Score = 44.4 bits (100), Expect = 0.011
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 16/118 (13%)
Query: 244 NEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASI 303
++ +E + Q + LL NILP ++ + S K I + H+ + V+F
Sbjct: 179 DKSEESLMAEQKKSDDLLHNILPANIIRDLKESGKTIPK------RHKD---ITVLFTDF 229
Query: 304 PNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
NF++ + + + LN+I FDEI+AE +EKI++ G +YMAA GL
Sbjct: 230 ENFTKLVASISA----ITLVNELNDIFGRFDEIMAETE---VEKIETIGDSYMAACGL 280
>UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|Rep:
Guanylyl cyclase - Caenorhabditis elegans
Length = 1017
Score = 64.5 bits (150), Expect = 1e-08
Identities = 34/76 (44%), Positives = 46/76 (60%), Gaps = 1/76 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL-SARG 493
R+ G + GP+ AGVIG R P+Y ++G+ VN ASRM S + IQ ++ +L +
Sbjct: 924 RIRIGFHAGPIAAGVIGIRSPRYCLFGDTVNFASRMQSNCPPNQIQTSEITARLLFDSHE 983
Query: 494 YKLRCRGTVDVKGKGN 509
YK RG V VKGKGN
Sbjct: 984 YKFVKRGIVHVKGKGN 999
Score = 48.8 bits (111), Expect = 5e-04
Identities = 37/118 (31%), Positives = 58/118 (49%), Gaps = 13/118 (11%)
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
+S VMF I +F+ L + + + LN+I FD ++ K+++TG
Sbjct: 827 ESATVMFVQICDFNA----LMKRSSPEQVIAFLNDIYDQFDTVIKRHD---AYKVETTGE 879
Query: 354 TYMAASGLTNSTQDLVGYRHVTAMADYALRLRE-QLQYVNEHSFNC-FRIRIGKSCSP 409
TYM ASG+ + + RH+ +A+ +L +RE YV +H N RIRIG P
Sbjct: 880 TYMVASGVPHENEG----RHIFEVAEISLEIREISYIYVLQHDKNYKLRIRIGFHAGP 933
>UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 918
Score = 64.5 bits (150), Expect = 1e-08
Identities = 33/83 (39%), Positives = 51/83 (61%), Gaps = 1/83 (1%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYK 495
+ G++ G VVAGV+G R PQY ++G+ VN+ASR+ +T L I ++ + L +
Sbjct: 815 ITIGMHSGAVVAGVVGKRTPQYCLFGHTVNIASRLRTTALPMRIHISNSCNECLLNTEFH 874
Query: 496 LRCRGTVDVKG-KGNMVTYFLEG 517
RGT+ +KG +G M TY+L G
Sbjct: 875 TEFRGTILLKGIQGEMKTYWLIG 897
>UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-33 -
Caenorhabditis elegans
Length = 945
Score = 64.1 bits (149), Expect = 1e-08
Identities = 34/85 (40%), Positives = 53/85 (62%), Gaps = 4/85 (4%)
Query: 436 VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLD-HIQVTQEVYDIL---SA 491
+ GI GPVV GV+G R P+Y ++G+ VN ASRM+S+ IQ+ Q D + ++
Sbjct: 532 IKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQAS 591
Query: 492 RGYKLRCRGTVDVKGKGNMVTYFLE 516
++++ +G V VKGKG+M Y +E
Sbjct: 592 GAFRIKPKGNVFVKGKGDMRVYEIE 616
>UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena
pyriformis|Rep: Guanylyl cyclase - Tetrahymena pyriformis
Length = 2794
Score = 63.7 bits (148), Expect = 2e-08
Identities = 30/79 (37%), Positives = 49/79 (62%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G V+AGVIG KPQ+ + G+ VN+ASR+ STG + + ++ E Y+ + +
Sbjct: 1854 KIKIGIHYGRVIAGVIGCHKPQFSLIGDTVNMASRVCSTGDVGQVTISDEAYEEIKQVPH 1913
Query: 495 KLRCRGTVDVKGKGNMVTY 513
+ V KGKG++ TY
Sbjct: 1914 INFLKKKVYAKGKGDITTY 1932
Score = 39.5 bits (88), Expect = 0.32
Identities = 18/51 (35%), Positives = 31/51 (60%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G + GVIG +YDI+G V VA++M+S G + V++ ++L
Sbjct: 2709 GVHTGSYIGGVIGTDIVRYDIYGPDVMVANKMESNGEQGKVMVSKTTMNLL 2759
>UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_12, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2459
Score = 63.7 bits (148), Expect = 2e-08
Identities = 31/79 (39%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
++ GI+ G V AGVIG KPQ+ + G+ VN ASRM STG + I ++ E Y+ + +
Sbjct: 1761 KIKIGIHYGQVFAGVIGYHKPQFSLIGDTVNTASRMCSTGEVGRITISSEAYERVKDTEF 1820
Query: 495 KLRCRGTVDVKGKGNMVTY 513
R V+ KGKG+++ +
Sbjct: 1821 LFTSR-EVEAKGKGHLIVH 1838
>UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylate
cyclase A; n=14; cellular organisms|Rep: Natriuretic
peptide receptor A/guanylate cyclase A - Homo sapiens
(Human)
Length = 255
Score = 63.7 bits (148), Expect = 2e-08
Identities = 43/118 (36%), Positives = 65/118 (55%), Gaps = 10/118 (8%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 139 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 195
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGN---MVTYFLEGVGDSIPDDIYN-NPIP 532
++ E +L G++L RG V++K +G + T++ G S P N PIP
Sbjct: 196 HLSSETKAVLEEFGGFELELRGDVEMKVEGEASALPTFW--GPRGSYPSQAANATPIP 251
>UniRef50_Q5CUX5 Cluster: P-type ATpase fused to two adenyl cyclase
domains and 21 predicted transmembrane regions; n=2;
Cryptosporidium|Rep: P-type ATpase fused to two adenyl
cyclase domains and 21 predicted transmembrane regions -
Cryptosporidium parvum Iowa II
Length = 3848
Score = 63.3 bits (147), Expect = 2e-08
Identities = 41/115 (35%), Positives = 58/115 (50%), Gaps = 2/115 (1%)
Query: 407 CSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNV 466
CS D + N + E AL ++ GI+ G V++GV+G KPQY ++G+ VN
Sbjct: 2840 CSSKDRKGNKNNSFIFTGQEM--ALKQLKLKIGIHSGRVISGVVGTNKPQYALFGDTVNT 2897
Query: 467 ASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDS 521
ASRM S+ IQV+ +D++ VKGKG M T+ LE V S
Sbjct: 2898 ASRMKSSCETGKIQVSSMTHDLVKDISILKWKEKRSFVKGKGMMDTFTLESVSGS 2952
Score = 46.4 bits (105), Expect = 0.003
Identities = 15/52 (28%), Positives = 37/52 (71%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G + G++G+ + +Y++WG+ V + +RM+S G +I ++ +++++LS
Sbjct: 3733 GLHYGGCIGGIVGSSRLRYEVWGHDVIIGNRMESCGTPGNITISGQLHEVLS 3784
>UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 63.3 bits (147), Expect = 2e-08
Identities = 32/89 (35%), Positives = 55/89 (61%), Gaps = 5/89 (5%)
Query: 419 CTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDH 478
C ++ P ++VR G + GPV AGV+G P+Y ++G+ VN ASRM+STG+ +
Sbjct: 1012 CNFKLAHRPEELMMVR---IGFHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANK 1068
Query: 479 IQVTQEVYDILSA--RGYKLRCRGTVDVK 505
IQ+++ Y++L +++ RG ++VK
Sbjct: 1069 IQISEGAYNLLHCFFPQFQMVERGKIEVK 1097
>UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, whole
genome shotgun sequence; n=5; Alveolata|Rep: Chromosome
undetermined scaffold_66, whole genome shotgun sequence -
Paramecium tetraurelia
Length = 2408
Score = 63.3 bits (147), Expect = 2e-08
Identities = 31/79 (39%), Positives = 47/79 (59%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G ++GVIG KPQ+ + G+ VN SR+ STGL D I ++++ +D L +
Sbjct: 1735 GIHYGGAISGVIGFHKPQFSLIGDTVNTTSRICSTGLEDAITLSEQAFDQLKNENIEFEI 1794
Query: 499 RGTVDVKGKGNMVTYFLEG 517
R V++KG G TY +G
Sbjct: 1795 R-NVEMKGLGTRPTYIFKG 1812
Score = 45.6 bits (103), Expect = 0.005
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 3/95 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQV---TQEVYDILSARGYK 495
G++ GPV GV+G +YDI+G V +A++M+S G+ ++QV T++ + L + Y
Sbjct: 2313 GVHTGPVFGGVMGTDIVRYDIYGPDVLIANKMESNGVKGNVQVSQSTKKYLEELYSDLYN 2372
Query: 496 LRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNP 530
+++K G + +L + P + N P
Sbjct: 2373 FEFNVNLELKSIGRQIEGYLVKKYEEDPVNEQNIP 2407
Score = 37.9 bits (84), Expect = 0.96
Identities = 35/151 (23%), Positives = 68/151 (45%), Gaps = 19/151 (12%)
Query: 240 KLQANEEKEDMEHLQAYNR--KLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC 297
+L+ ++ + + ++ N+ +L +LP+ + DQ++ H+ V
Sbjct: 1581 QLEEDQAQNKLNFIEQNNKINDILGILLPKFIRDRL----NETDQYNI----HQNQGLVA 1632
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
++F I NF + E E + + L++I FD+ ++KI++ G TY+A
Sbjct: 1633 IVFCDICNFDQMVTE-----EKDKIITFLDDIFRTFDKYCQ---IYGVQKIETVGKTYLA 1684
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQL 388
++GL Q+L Y AL L EQ+
Sbjct: 1685 SAGLKACEQELT-YLSQVDPVQRALNLAEQM 1714
>UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular
organisms|Rep: Guanylyl cyclase - Dictyostelium
discoideum (Slime mold)
Length = 1486
Score = 62.5 bits (145), Expect = 4e-08
Identities = 34/82 (41%), Positives = 51/82 (62%), Gaps = 3/82 (3%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
+V G++ GPVV G+IG +K + ++G+ +N +SRM S + IQV+ V +L R Y
Sbjct: 481 QVRIGMHTGPVVGGIIGKKKLSWHLFGDTINTSSRMASHSSIGRIQVSHPVQQLL--RPY 538
Query: 495 KL-RCRGTVDVKGKGNMVTYFL 515
L RG + VKGKG M T++L
Sbjct: 539 FLFEDRGKIQVKGKGLMRTFYL 560
Score = 60.5 bits (140), Expect = 2e-07
Identities = 30/81 (37%), Positives = 49/81 (60%), Gaps = 2/81 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GI+ GPV+AGV+G + Y +WG +V + +M+ST D I V+++ ++IL ++ Y
Sbjct: 1263 RMRIGIHTGPVIAGVVGIKMIHYQLWGESVQITQQMESTSRADMIHVSEDTFNILKSK-Y 1321
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
R +K K + TYFL
Sbjct: 1322 LFEERPDGIIK-KRKIKTYFL 1341
Score = 35.1 bits (77), Expect = 6.8
Identities = 30/124 (24%), Positives = 55/124 (44%), Gaps = 11/124 (8%)
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYI 345
++L ++ +V + + I F+E + + + LN+I + FDEI E F +
Sbjct: 1160 RQLIVDEFKNVTIFLSDIVGFTEMAARMSPR----QLVETLNQIYSTFDEIAQE--FGVL 1213
Query: 346 EKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGK 405
KI + G Y SG + Q H +A+ A+++ E ++ + R+RIG
Sbjct: 1214 -KIATIGDAYFCVSGCPDKDQT----DHAFRVANMAIKMLESIKSIRTVDNIPIRMRIGI 1268
Query: 406 SCSP 409
P
Sbjct: 1269 HTGP 1272
>UniRef50_A2DTD4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 475
Score = 62.5 bits (145), Expect = 4e-08
Identities = 31/91 (34%), Positives = 56/91 (61%), Gaps = 4/91 (4%)
Query: 435 RVPAGINIG-PVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARG 493
++ G+N G P+VAGV+G +P ++I G A+N+A +M+ G+ + +++ VY+ + G
Sbjct: 388 QIRVGVNTGGPIVAGVLGVGRPTFEILGPAINMAQQMEHHGVPMKVHISRSVYENIYESG 447
Query: 494 YKLRCRGTVDVKGKGNMVTYFLEGVGDSIPD 524
+ + RG V+VK G + TY ++ D PD
Sbjct: 448 FVIHERGEVEVK-NGKVTTYLVD--PDENPD 475
>UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 420
Score = 62.1 bits (144), Expect = 5e-08
Identities = 28/79 (35%), Positives = 47/79 (59%), Gaps = 1/79 (1%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN G VVAGV+G +K YDIWG+AVN A+R++ + ++ + ++ ++L
Sbjct: 340 GINTGTVVAGVVGDKKYVYDIWGDAVNTAARIEENSAPGRVNISAFTHQVVKEH-FELEE 398
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + K KG + +++ G
Sbjct: 399 RGLISAKNKGKIEMFWVLG 417
Score = 38.7 bits (86), Expect = 0.55
Identities = 48/194 (24%), Positives = 83/194 (42%), Gaps = 21/194 (10%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+A A+ VA+ T + + L A +++ + E ++ N LL NI P +A+
Sbjct: 167 LAFAMAGLVAIFFLIANTFEKLKQQALESLVAKQKELEFEQERSEN--LLLNIFPADIAE 224
Query: 272 HFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 331
+ + Q H D+V V+FA + NF+ + EG + + LL+
Sbjct: 225 ELKSTGRT------QARLH---DNVTVLFADVKNFT---IVSEGLLPD-QLVALLDTYFQ 271
Query: 332 DFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYV 391
D I+ + +EKIK+ G Y+AA+G+ + R V A A + + + +
Sbjct: 272 RIDAIIQKHG---LEKIKTIGDAYLAAAGVPKGNKATA--RDVVAAALEIQKTNDAYKVL 326
Query: 392 NE-HSFNCFRIRIG 404
E F RIG
Sbjct: 327 RETEGLPFFDFRIG 340
>UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1154
Score = 61.3 bits (142), Expect = 9e-08
Identities = 73/275 (26%), Positives = 126/275 (45%), Gaps = 58/275 (21%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E +++E + KL+ +LP+ VAQ L + + E Y E + F+ I
Sbjct: 901 ERTDELEVERTKTDKLVGQLLPKSVAQA-LKKGRPVQP----EHYSEST----LYFSDIV 951
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+A + K+++ G YM ASG+ N
Sbjct: 952 GFTT----ISALSEPIEVVDLLNDLYTMFDAIIATHD---VYKVETIGDAYMVASGVPNR 1004
Query: 365 TQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVR 424
G RH +A+ +L + HS F+I+ P ++V+
Sbjct: 1005 N----GNRHAAEVANMSLDIL--------HSIAAFKIK----HMPE----------IKVK 1038
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ G ++ GPVVAGV+G P+Y ++G+ V AS M+++GL I ++
Sbjct: 1039 IRIG-----------LHSGPVVAGVVGLTMPRYCLFGDTVTTASHMEASGLPYRIHISLS 1087
Query: 485 VYDILSA--RGYKLRCRGTVDVKGKGNMVTYFLEG 517
+L++ GY + R + KG + TY+L G
Sbjct: 1088 TVKVLTSLKLGYHMETR---KAQVKGAVDTYWLVG 1119
>UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA -
Drosophila melanogaster (Fruit fly)
Length = 787
Score = 61.3 bits (142), Expect = 9e-08
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 6/94 (6%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR-- 492
++ GI+ G VV GVIG R P+Y ++GN VN+ SR ++TG+ I V++E Y +L
Sbjct: 628 QITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAIN 687
Query: 493 ---GYKLRCRGTVDVKGKGN-MVTYFLEGVGDSI 522
+ L RG V +KGK M +FL SI
Sbjct: 688 QDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSI 721
Score = 52.4 bits (120), Expect = 4e-05
Identities = 46/186 (24%), Positives = 90/186 (48%), Gaps = 18/186 (9%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRK---LLANILPEHVAQHFLCSDK 278
L+L S++ E+ Y+L ++ ++ ++ L++ +K LL ++LP+ VA
Sbjct: 462 LVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELR---- 517
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
+ + ++ DSV +MF+ I F ++ + ++ +++LNE+ FD +
Sbjct: 518 -----HQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTD 572
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+ + K+++ G YMA SGL + +D H MA AL + + + V S N
Sbjct: 573 SKRNLNVYKVETVGDKYMAVSGLPDHCED-----HAKCMARVALDMMDMAKNVKMGS-NP 626
Query: 399 FRIRIG 404
+I IG
Sbjct: 627 VQITIG 632
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.322 0.136 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 729,861,855
Number of Sequences: 1657284
Number of extensions: 28660732
Number of successful extensions: 79180
Number of sequences better than 10.0: 460
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 77928
Number of HSP's gapped (non-prelim): 979
length of query: 731
length of database: 575,637,011
effective HSP length: 106
effective length of query: 625
effective length of database: 399,964,907
effective search space: 249978066875
effective search space used: 249978066875
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 76 (34.7 bits)
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