Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002066-TA|BGIBMGA002066-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(731 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein. 263 2e-69
AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type V... 263 2e-69
AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein. 263 2e-69
AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type ... 260 9e-69
BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (br... 215 6e-55
AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type I... 215 6e-55
AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein. 215 6e-55
X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein. 206 2e-52
L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein. 206 2e-52
AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein. 206 2e-52
Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein. 206 3e-52
M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V p... 206 3e-52
DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase... 202 3e-51
L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein. 192 3e-48
AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase... 192 3e-48
D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein. 175 5e-43
BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7 pro... 175 5e-43
BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4 pro... 174 1e-42
BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4 pro... 174 1e-42
AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens ... 174 1e-42
AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type ... 174 1e-42
AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type I... 166 3e-40
AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein. 166 3e-40
DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9... 165 7e-40
DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9... 165 7e-40
AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type ... 165 7e-40
AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type I... 165 7e-40
BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 pro... 159 3e-38
AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cycla... 159 3e-38
AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein. 159 3e-38
AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein. 159 3e-38
AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens ... 158 7e-38
BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein. 110 1e-23
AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclas... 82 6e-15
BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein. 78 1e-13
AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide re... 78 1e-13
AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic pept... 78 1e-13
L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein. 77 3e-13
AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F, r... 77 3e-13
X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein... 75 7e-13
BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide rec... 75 7e-13
AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide rec... 75 7e-13
AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide rec... 75 7e-13
AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A t... 75 7e-13
M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein. 74 2e-12
AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein. 74 2e-12
S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled... 70 3e-11
M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin r... 70 3e-11
S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptid... 69 4e-11
AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide rec... 64 2e-09
X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein. 58 1e-07
BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1, so... 58 1e-07
AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cycla... 58 1e-07
Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of solubl... 53 4e-06
AK131333-1|BAD18492.1| 174|Homo sapiens 9. protein. 52 6e-06
BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein. 50 3e-05
AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens ... 50 3e-05
X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble... 47 3e-04
BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1, so... 47 3e-04
BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1, so... 47 3e-04
U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V p... 46 5e-04
Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase ... 44 0.003
X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein. 44 0.003
U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase... 44 0.003
BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein. 44 0.003
AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cycla... 44 0.003
AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein. 42 0.008
L26921-1|AAA60366.1| 80|Homo sapiens guanyl cyclase protein. 36 0.39
AL590452-8|CAH72528.1| 2240|Homo sapiens phosphodiesterase 4D in... 32 6.3
AL590452-4|CAH72524.1| 2346|Homo sapiens phosphodiesterase 4D in... 32 6.3
AL590452-3|CAH72523.1| 2362|Homo sapiens phosphodiesterase 4D in... 32 6.3
AL138796-7|CAI22827.1| 2240|Homo sapiens phosphodiesterase 4D in... 32 6.3
AL138796-4|CAI22824.1| 2346|Homo sapiens phosphodiesterase 4D in... 32 6.3
AL138796-3|CAI22823.1| 2362|Homo sapiens phosphodiesterase 4D in... 32 6.3
AB007923-1|BAA32299.2| 2296|Homo sapiens KIAA0454 protein protein. 32 6.3
>BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein.
Length = 1168
Score = 263 bits (644), Expect = 2e-69
Identities = 127/196 (64%), Positives = 155/196 (79%), Gaps = 5/196 (2%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHF 273
I L +AL LH+QQ EST RLDF+WKLQA EKE+ME LQAYNR+LL NILP+ VA HF
Sbjct: 901 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960
Query: 274 LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 333
L ++ D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADF
Sbjct: 961 LARERRND-----ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 1015
Query: 334 DEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNE 393
DEI++EE F+ +EKIK+ G+TYMAASGL ST D VG H+TA+ADYA+RL EQ++++NE
Sbjct: 1016 DEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINE 1075
Query: 394 HSFNCFRIRIGKSCSP 409
HSFN F+++IG + P
Sbjct: 1076 HSFNNFQMKIGLNMGP 1091
Score = 133 bits (321), Expect = 2e-30
Identities = 58/79 (73%), Positives = 68/79 (86%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N+GPVVAGVIGARKPQYDIWGN VNV+SRMDSTG+ D IQVT ++Y +L+A+GY+L C
Sbjct: 1086 GLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC 1145
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M TYFL G
Sbjct: 1146 RGVVKVKGKGEMTTYFLNG 1164
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/288 (23%), Positives = 116/288 (40%), Gaps = 50/288 (17%)
Query: 205 WNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANI 264
W Q N+ + L V + E + R F + + ++H +LL ++
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
Query: 265 LPEHVAQHFLCSDKNIDQFDA--QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
LP+HVA + D N + D ++Y ++ D+V ++FA I F+ L E
Sbjct: 346 LPQHVAME-MKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFT----SLASQCTAQEL 400
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+ LNE+ A FD++ AE + +IK G Y SGL + D H + +
Sbjct: 401 VMTLNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARAD-----HAHCCVEMGV 452
Query: 383 RLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINI 442
+ E + V E + N +RV + G RV G+
Sbjct: 453 DMIEAISLVRE--------------------VTGVNVNMRVGIHSG------RVHCGV-- 484
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
+G RK Q+D+W N V +A+ M++ G I +T+ L+
Sbjct: 485 -------LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN 525
>AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type VI
protein.
Length = 1168
Score = 263 bits (644), Expect = 2e-69
Identities = 127/196 (64%), Positives = 155/196 (79%), Gaps = 5/196 (2%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHF 273
I L +AL LH+QQ EST RLDF+WKLQA EKE+ME LQAYNR+LL NILP+ VA HF
Sbjct: 901 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960
Query: 274 LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 333
L ++ D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADF
Sbjct: 961 LARERRND-----ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 1015
Query: 334 DEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNE 393
DEI++EE F+ +EKIK+ G+TYMAASGL ST D VG H+TA+ADYA+RL EQ++++NE
Sbjct: 1016 DEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINE 1075
Query: 394 HSFNCFRIRIGKSCSP 409
HSFN F+++IG + P
Sbjct: 1076 HSFNNFQMKIGLNMGP 1091
Score = 133 bits (321), Expect = 2e-30
Identities = 58/79 (73%), Positives = 68/79 (86%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N+GPVVAGVIGARKPQYDIWGN VNV+SRMDSTG+ D IQVT ++Y +L+A+GY+L C
Sbjct: 1086 GLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC 1145
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M TYFL G
Sbjct: 1146 RGVVKVKGKGEMTTYFLNG 1164
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/288 (23%), Positives = 116/288 (40%), Gaps = 50/288 (17%)
Query: 205 WNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANI 264
W Q N+ + L V + E + R F + + ++H +LL ++
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
Query: 265 LPEHVAQHFLCSDKNIDQFDA--QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
LP+HVA + D N + D ++Y ++ D+V ++FA I F+ L E
Sbjct: 346 LPQHVAME-MKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFT----SLASQCTAQEL 400
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+ LNE+ A FD++ AE + +IK G Y SGL + D H + +
Sbjct: 401 VMTLNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARAD-----HAHCCVEMGV 452
Query: 383 RLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINI 442
+ E + V E + N +RV + G RV G+
Sbjct: 453 DMIEAISLVRE--------------------VTGVNVNMRVGIHSG------RVHCGV-- 484
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
+G RK Q+D+W N V +A+ M++ G I +T+ L+
Sbjct: 485 -------LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN 525
>AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein.
Length = 1160
Score = 263 bits (644), Expect = 2e-69
Identities = 127/196 (64%), Positives = 155/196 (79%), Gaps = 5/196 (2%)
Query: 214 IALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHF 273
I L +AL LH+QQ EST RLDF+WKLQA EKE+ME LQAYNR+LL NILP+ VA HF
Sbjct: 893 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 952
Query: 274 LCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 333
L ++ D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADF
Sbjct: 953 LARERRND-----ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADF 1007
Query: 334 DEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNE 393
DEI++EE F+ +EKIK+ G+TYMAASGL ST D VG H+TA+ADYA+RL EQ++++NE
Sbjct: 1008 DEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINE 1067
Query: 394 HSFNCFRIRIGKSCSP 409
HSFN F+++IG + P
Sbjct: 1068 HSFNNFQMKIGLNMGP 1083
Score = 133 bits (321), Expect = 2e-30
Identities = 58/79 (73%), Positives = 68/79 (86%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N+GPVVAGVIGARKPQYDIWGN VNV+SRMDSTG+ D IQVT ++Y +L+A+GY+L C
Sbjct: 1078 GLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC 1137
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M TYFL G
Sbjct: 1138 RGVVKVKGKGEMTTYFLNG 1156
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/288 (23%), Positives = 116/288 (40%), Gaps = 50/288 (17%)
Query: 205 WNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANI 264
W Q N+ + L V + E + R F + + ++H +LL ++
Sbjct: 331 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 390
Query: 265 LPEHVAQHFLCSDKNIDQFDA--QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVEC 322
LP+HVA + D N + D ++Y ++ D+V ++FA I F+ L E
Sbjct: 391 LPQHVAME-MKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFT----SLASQCTAQEL 445
Query: 323 LRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYAL 382
+ LNE+ A FD++ AE + +IK G Y SGL + D H + +
Sbjct: 446 VMTLNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARAD-----HAHCCVEMGV 497
Query: 383 RLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINI 442
+ E + V E + N +RV + G RV G+
Sbjct: 498 DMIEAISLVRE--------------------VTGVNVNMRVGIHSG------RVHCGV-- 529
Query: 443 GPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
+G RK Q+D+W N V +A+ M++ G I +T+ L+
Sbjct: 530 -------LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN 570
>AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type V
protein.
Length = 894
Score = 260 bits (638), Expect = 9e-69
Identities = 122/190 (64%), Positives = 154/190 (81%), Gaps = 5/190 (2%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+AL LH+QQ EST RLDF+WKLQA EEKE+ME LQAYNR+LL NILP+ VA HFL ++
Sbjct: 632 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 691
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
D ELY++ C+ V VMFASI NFSEFYVELE NNEGVECLRLLNEIIADFDEI++E
Sbjct: 692 ND-----ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 746
Query: 340 EPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCF 399
+ F+ +EKIK+ G+TYMAASGL +ST D VG H+ A+AD+A++L +Q++Y+NEHSFN F
Sbjct: 747 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 806
Query: 400 RIRIGKSCSP 409
+++IG + P
Sbjct: 807 QMKIGLNIGP 816
Score = 132 bits (318), Expect = 6e-30
Identities = 59/79 (74%), Positives = 67/79 (84%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+NIGPVVAGVIGARKPQYDIWGN VNVASRMDSTG+ D IQVT ++Y +L+A Y+L C
Sbjct: 811 GLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC 870
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG V VKGKG M+TYFL G
Sbjct: 871 RGVVKVKGKGEMMTYFLNG 889
Score = 59.3 bits (137), Expect = 5e-08
Identities = 67/261 (25%), Positives = 111/261 (42%), Gaps = 53/261 (20%)
Query: 259 KLLANILPEHVAQHFLCSDKNIDQFDAQ--ELYHEQCDSVCVMFASIPNFSEFYVELEGN 316
+LL ++LP HVA + +D N Q D ++Y ++ D+V ++FA I F+ L
Sbjct: 63 RLLLSVLPRHVAME-MKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS----LASQ 117
Query: 317 NEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTA 376
E + LNE+ A FD++ AE + +IK G Y SGL + D H
Sbjct: 118 CTAQELVMTLNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARAD-----HAHC 169
Query: 377 MADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRV 436
+ + + E + V E + N +RV + G RV
Sbjct: 170 CVEMGMDMIEAISLVRE--------------------VTGVNVNMRVGIHSG------RV 203
Query: 437 PAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKL 496
G+ +G RK Q+D+W N V +A+ M++ G I +T+ + L+ Y++
Sbjct: 204 HCGV---------LGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEV 253
Query: 497 R--CRGTVDVKGKGNMVTYFL 515
C G + K + + FL
Sbjct: 254 EPGCGGERNAYLKEHSIETFL 274
>BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (brain)
protein.
Length = 1091
Score = 215 bits (524), Expect = 6e-55
Identities = 166/528 (31%), Positives = 253/528 (47%), Gaps = 57/528 (10%)
Query: 9 DRVCAVQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTY 68
++V +Y A K Y +C+ +++ + IVQ+L T + + +++ + +
Sbjct: 585 NKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILF 644
Query: 69 LIFAIDLKFAGGKLKRI------SKRVHNNRTLAQLMSFIVVGAVILQIQVVMV------ 116
+ FA L K + S + NR ++ I+ A+IL + V +
Sbjct: 645 VCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDS 704
Query: 117 QEVLGVTNNTNVPSYENSGGNCPYDMNE------HYLQVTLMAMFLCAVHQIXXXXXXXX 170
+E + T NT S+ S + +++ ++ + C+V
Sbjct: 705 EETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKML 764
Query: 171 XXXXXXXXXXXXXXQEHLYYRNHFYDYQ-HRCGLDWNQQWTNIAIALGAT-VALLLHSQQ 228
H + + R G+ W T +++L + LL+ +Q
Sbjct: 765 IMMVALVGYNTILLHTHAHVLGDYSQVLFERPGI-WKDLKTMGSVSLSIFFITLLVLGRQ 823
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDKNIDQFDAQE 287
E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S KN +E
Sbjct: 824 NEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKN------EE 877
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A+ + K
Sbjct: 878 LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIADFD-DLLSK 929
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
K +G + G T G V + +++ Q ++ F + +GK
Sbjct: 930 PKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFAFAL-VGKL- 984
Query: 408 SPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVA 467
DA + ++RV GIN GPV+AGVIGA+KPQYDIWGN VNVA
Sbjct: 985 ---DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYDIWGNTVNVA 1028
Query: 468 SRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
SRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 1029 SRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 1076
Score = 45.2 bits (102), Expect = 8e-04
Identities = 26/81 (32%), Positives = 48/81 (59%), Gaps = 6/81 (7%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + ++ + L+ YK+
Sbjct: 385 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG-AYKVE- 442
Query: 499 RGTVDVKG---KGNMV-TYFL 515
G D++ K ++V TYF+
Sbjct: 443 EGDGDIRDPYLKQHLVKTYFV 463
Score = 32.7 bits (71), Expect = 4.8
Identities = 39/171 (22%), Positives = 67/171 (39%), Gaps = 22/171 (12%)
Query: 203 LDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLA 262
L W Q N+ I + +A H E + + + + +E + +LL
Sbjct: 187 LVW-QILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245
Query: 263 NILPEHVAQHFLC------------SDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFY 310
++LP H+A +N + F LY ++ +V +++A I F+
Sbjct: 246 SLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNF--HNLYVKRHTNVSILYADIVGFT--- 300
Query: 311 VELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
L + E + +LNE+ FD+I E +IK G Y SGL
Sbjct: 301 -RLASDCSPGELVHMLNELFGKFDQIAKENE---CMRIKILGDCYYCVSGL 347
>AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type II
protein.
Length = 1091
Score = 215 bits (524), Expect = 6e-55
Identities = 166/528 (31%), Positives = 253/528 (47%), Gaps = 57/528 (10%)
Query: 9 DRVCAVQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTY 68
++V +Y A K Y +C+ +++ + IVQ+L T + + +++ + +
Sbjct: 585 NKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILF 644
Query: 69 LIFAIDLKFAGGKLKRI------SKRVHNNRTLAQLMSFIVVGAVILQIQVVMV------ 116
+ FA L K + S + NR ++ I+ A+IL + V +
Sbjct: 645 VCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDS 704
Query: 117 QEVLGVTNNTNVPSYENSGGNCPYDMNE------HYLQVTLMAMFLCAVHQIXXXXXXXX 170
+E + T NT S+ S + +++ ++ + C+V
Sbjct: 705 EETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKML 764
Query: 171 XXXXXXXXXXXXXXQEHLYYRNHFYDYQ-HRCGLDWNQQWTNIAIALGAT-VALLLHSQQ 228
H + + R G+ W T +++L + LL+ +Q
Sbjct: 765 IMMVALVGYNTILLHTHAHVLGDYSQVLFERPGI-WKDLKTMGSVSLSIFFITLLVLGRQ 823
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDKNIDQFDAQE 287
E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S KN +E
Sbjct: 824 NEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKN------EE 877
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A+ + K
Sbjct: 878 LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIADFD-DLLSK 929
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
K +G + G T G V + +++ Q ++ F + +GK
Sbjct: 930 PKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFAFAL-VGKL- 984
Query: 408 SPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVA 467
DA + ++RV GIN GPV+AGVIGA+KPQYDIWGN VNVA
Sbjct: 985 ---DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYDIWGNTVNVA 1028
Query: 468 SRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
SRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 1029 SRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 1076
Score = 45.2 bits (102), Expect = 8e-04
Identities = 26/81 (32%), Positives = 48/81 (59%), Gaps = 6/81 (7%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + ++ + L+ YK+
Sbjct: 385 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG-AYKVE- 442
Query: 499 RGTVDVKG---KGNMV-TYFL 515
G D++ K ++V TYF+
Sbjct: 443 EGDGDIRDPYLKQHLVKTYFV 463
>AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein.
Length = 887
Score = 215 bits (524), Expect = 6e-55
Identities = 166/528 (31%), Positives = 253/528 (47%), Gaps = 57/528 (10%)
Query: 9 DRVCAVQYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTY 68
++V +Y A K Y +C+ +++ + IVQ+L T + + +++ + +
Sbjct: 381 NKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILF 440
Query: 69 LIFAIDLKFAGGKLKRI------SKRVHNNRTLAQLMSFIVVGAVILQIQVVMV------ 116
+ FA L K + S + NR ++ I+ A+IL + V +
Sbjct: 441 VCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDS 500
Query: 117 QEVLGVTNNTNVPSYENSGGNCPYDMNE------HYLQVTLMAMFLCAVHQIXXXXXXXX 170
+E + T NT S+ S + +++ ++ + C+V
Sbjct: 501 EETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKML 560
Query: 171 XXXXXXXXXXXXXXQEHLYYRNHFYDYQ-HRCGLDWNQQWTNIAIALGAT-VALLLHSQQ 228
H + + R G+ W T +++L + LL+ +Q
Sbjct: 561 IMMVALVGYNTILLHTHAHVLGDYSQVLFERPGI-WKDLKTMGSVSLSIFFITLLVLGRQ 619
Query: 229 TESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDKNIDQFDAQE 287
E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S KN +E
Sbjct: 620 NEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKN------EE 673
Query: 288 LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEK 347
LYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A+ + K
Sbjct: 674 LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIADFD-DLLSK 725
Query: 348 IKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSC 407
K +G + G T G V + +++ Q ++ F + +GK
Sbjct: 726 PKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFAFAL-VGKL- 780
Query: 408 SPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVA 467
DA + ++RV GIN GPV+AGVIGA+KPQYDIWGN VNVA
Sbjct: 781 ---DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYDIWGNTVNVA 824
Query: 468 SRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
SRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 825 SRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 872
Score = 45.2 bits (102), Expect = 8e-04
Identities = 26/81 (32%), Positives = 48/81 (59%), Gaps = 6/81 (7%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + ++ + L+ YK+
Sbjct: 181 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG-AYKVE- 238
Query: 499 RGTVDVKG---KGNMV-TYFL 515
G D++ K ++V TYF+
Sbjct: 239 EGDGDIRDPYLKQHLVKTYFV 259
>X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein.
Length = 476
Score = 206 bits (503), Expect = 2e-52
Identities = 129/297 (43%), Positives = 173/297 (58%), Gaps = 36/297 (12%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDK 278
+ LL+ +Q E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S K
Sbjct: 200 ITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLK 259
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
N +ELYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A
Sbjct: 260 N------EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIA 306
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+ + K K +G + G T G V + +++ Q ++
Sbjct: 307 DFD-DLLSKPKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFA 362
Query: 399 FRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYD 458
F + +GK DA + ++RV GIN GPV+AGVIGA+KPQYD
Sbjct: 363 FAL-VGKL----DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYD 404
Query: 459 IWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
IWGN VNVASRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 405 IWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 461
>L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein.
Length = 476
Score = 206 bits (503), Expect = 2e-52
Identities = 129/297 (43%), Positives = 173/297 (58%), Gaps = 36/297 (12%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDK 278
+ LL+ +Q E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S K
Sbjct: 200 ITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLK 259
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
N +ELYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A
Sbjct: 260 N------EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIA 306
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+ + K K +G + G T G V + +++ Q ++
Sbjct: 307 DFD-DLLSKPKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFA 362
Query: 399 FRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYD 458
F + +GK DA + ++RV GIN GPV+AGVIGA+KPQYD
Sbjct: 363 FAL-VGKL----DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYD 404
Query: 459 IWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
IWGN VNVASRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 405 IWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 461
>AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein.
Length = 367
Score = 206 bits (503), Expect = 2e-52
Identities = 129/297 (43%), Positives = 173/297 (58%), Gaps = 36/297 (12%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLC-SDK 278
+ LL+ +Q E RLDF+WK + +E+E++E ++ NR LL N+LP HVA+HFL S K
Sbjct: 91 ITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLK 150
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
N +ELYH+ D VCVMFASIP+F EFY E + N EG+ECLRLLN EI+A
Sbjct: 151 N------EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN-------EIIA 197
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNC 398
+ + K K +G + G T G V + +++ Q ++
Sbjct: 198 DFD-DLLSKPKFSGVEKIKTIGSTYMAA--TGLSAVPSQ-EHSQEPERQYMHIGTMVEFA 253
Query: 399 FRIRIGKSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYD 458
F + +GK DA + ++RV GIN GPV+AGVIGA+KPQYD
Sbjct: 254 FAL-VGKL----DAINKHSFNDFKLRV-------------GINHGPVIAGVIGAQKPQYD 295
Query: 459 IWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFL 515
IWGN VNVASRMDSTG+LD IQVT+E +L GY CRG ++VKGKG++ TYF+
Sbjct: 296 IWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 352
>Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein.
Length = 1251
Score = 206 bits (502), Expect = 3e-52
Identities = 105/214 (49%), Positives = 145/214 (67%), Gaps = 7/214 (3%)
Query: 195 YDYQHRCGLDW-NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHL 253
YD + G D+ + ++ + +A+ H QQ E T RLDF+W++QA EE +M+ L
Sbjct: 884 YDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKEL 943
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+ +N +L NILP HVA+HFL D+ D +ELY + D+V VMFASIP F++FY +
Sbjct: 944 REHNENMLRNILPSHVARHFLEKDR-----DNEELYSQSYDAVGVMFASIPGFADFYSQT 998
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YR 372
E NN+GVECLRLLNEIIADFDE+L E+ F+ IEKIK+ G+TYMA SGL+ Q +
Sbjct: 999 EMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWG 1058
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKS 406
H+ A+AD++L L E +Q +N+HSFN F +RIG S
Sbjct: 1059 HLCALADFSLALTESIQEINKHSFNNFELRIGIS 1092
Score = 93.9 bits (223), Expect = 2e-18
Identities = 53/106 (50%), Positives = 65/106 (61%), Gaps = 4/106 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQV +E Y IL +G+
Sbjct: 1090 GISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDY 1149
Query: 499 RGTVDVKG----KGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAV 540
RG + VKG +G + TYFL G P + +P S AV
Sbjct: 1150 RGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAV 1195
Score = 52.0 bits (119), Expect = 7e-06
Identities = 45/203 (22%), Positives = 83/203 (40%), Gaps = 16/203 (7%)
Query: 206 NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL 265
NQ + + A + S ++ R F+ + E + +E +L+ ++L
Sbjct: 319 NQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVL 378
Query: 266 PEHVAQHFLCSDKNIDQFDAQELYHE----QCDSVCVMFASIPNFSEFYVELEGNNEGVE 321
P V + N++ Q +H + ++V ++FA + F+ L E
Sbjct: 379 PRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ----E 434
Query: 322 CLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
+R+LNE+ A FD + E + +IK G Y SGL QD H +
Sbjct: 435 LVRMLNELFARFDRLAHEH---HCLRIKILGDCYYCVSGLPEPRQD-----HAHCCVEMG 486
Query: 382 LRLREQLQYVNEHSFNCFRIRIG 404
L + + ++YV + + +RIG
Sbjct: 487 LSMIKTIRYVRSRTKHDVDMRIG 509
Score = 52.0 bits (119), Expect = 7e-06
Identities = 53/231 (22%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 323 LRLLNEIIADFDEILAEEPFK-YIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYA 381
L ++N++ DE L + + YI + ++ + G TN + L V + +
Sbjct: 384 LEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELF 443
Query: 382 LRLREQLQYVNEHSFNCFRIRIGKSC-----SPSDATASSANCTLRVRVEPGGALIVRR- 435
R ++L H +C RI+I C + A+C + + + + R
Sbjct: 444 ARF-DRLA----HEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRS 498
Query: 436 -------VPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDI 488
+ GI+ G V+ GV+G RK Q+D+W V++A++++S G+ I +++ D
Sbjct: 499 RTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDC 558
Query: 489 LSARGYKLRCRGTV--DVKGKGNMVTYFLEGVGD---SIPDDIYNNPIPST 534
L+ G + K N+ TY ++ D S+P+DI + S+
Sbjct: 559 LNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSS 609
>M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V
protein.
Length = 675
Score = 206 bits (502), Expect = 3e-52
Identities = 105/214 (49%), Positives = 145/214 (67%), Gaps = 7/214 (3%)
Query: 195 YDYQHRCGLDW-NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHL 253
YD + G D+ + ++ + +A+ H QQ E T RLDF+W++QA EE +M+ L
Sbjct: 308 YDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKEL 367
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+ +N +L NILP HVA+HFL D+ D +ELY + D+V VMFASIP F++FY +
Sbjct: 368 REHNENMLRNILPSHVARHFLEKDR-----DNEELYSQSYDAVGVMFASIPGFADFYSQT 422
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YR 372
E NN+GVECLRLLNEIIADFDE+L E+ F+ IEKIK+ G+TYMA SGL+ Q +
Sbjct: 423 EMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWG 482
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKS 406
H+ A+AD++L L E +Q +N+HSFN F +RIG S
Sbjct: 483 HLCALADFSLALTESIQEINKHSFNNFELRIGIS 516
Score = 93.9 bits (223), Expect = 2e-18
Identities = 53/106 (50%), Positives = 65/106 (61%), Gaps = 4/106 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQV +E Y IL +G+
Sbjct: 514 GISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDY 573
Query: 499 RGTVDVKG----KGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAV 540
RG + VKG +G + TYFL G P + +P S AV
Sbjct: 574 RGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAV 619
>DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase 8
protein.
Length = 1120
Score = 202 bits (494), Expect = 3e-51
Identities = 104/214 (48%), Positives = 144/214 (67%), Gaps = 7/214 (3%)
Query: 195 YDYQHRCGLDW-NQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHL 253
YD + G D+ + ++ + +A+ H QQ E T RLDF+W++QA EE +M+ L
Sbjct: 753 YDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKEL 812
Query: 254 QAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVEL 313
+ +N +L NILP HVA+HFL D+ D +ELY + D+V VMFASIP F++FY +
Sbjct: 813 REHNENMLRNILPSHVARHFLEKDQ-----DNEELYSQSYDAVGVMFASIPGFADFYSQT 867
Query: 314 EGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVG-YR 372
E NN+GVECLRLLNEIIADFDE+L E+ F+ IEKIK+ G+TYMA SG + Q +
Sbjct: 868 EMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGPSPEKQQCEDKWG 927
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKS 406
H+ A+AD++L L E +Q +N+HSFN F +RIG S
Sbjct: 928 HLCALADFSLALTESIQEINKHSFNNFELRIGIS 961
Score = 93.5 bits (222), Expect = 2e-18
Identities = 48/83 (57%), Positives = 58/83 (69%), Gaps = 4/83 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G VVAGVIGA+KPQYDIWG VN+ASRMDSTG+ IQV +E Y IL +G+
Sbjct: 959 GISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDY 1018
Query: 499 RGTVDVKG----KGNMVTYFLEG 517
RG + VKG +G + TYFL G
Sbjct: 1019 RGEIYVKGISEQEGKIKTYFLLG 1041
Score = 54.4 bits (125), Expect = 1e-06
Identities = 31/101 (30%), Positives = 55/101 (54%), Gaps = 5/101 (4%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ G V+ GV+G RK Q+D+W V++A++++S G+ I +++ D L+
Sbjct: 509 GIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISEATLDCLNGDYNVEEG 568
Query: 499 RGTV--DVKGKGNMVTYFLEGVGD---SIPDDIYNNPIPST 534
G + GK N+ TY ++ D S+P+DI + S+
Sbjct: 569 HGKERNEFLGKHNIETYLIKQPEDSLLSLPEDIVKESVSSS 609
Score = 52.0 bits (119), Expect = 7e-06
Identities = 42/183 (22%), Positives = 78/183 (42%), Gaps = 16/183 (8%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
S ++ R F+ + E + +E +L+ ++LP V + N++
Sbjct: 339 SYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDGHL 398
Query: 286 QELYHE----QCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
Q +H + ++V ++FA + F+ L E +R+LNE+ A FD ++ E
Sbjct: 399 QHQFHRIYIHRYENVSILFADVKGFTNLSATLSAQ----ELVRMLNELFARFDRLVHEH- 453
Query: 342 FKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRI 401
+ +IK G Y SGL QD H + L + + ++YV + + +
Sbjct: 454 --HCLRIKILGDCYYCVSGLPEPRQD-----HAHCCVEMGLSMIKTIRYVRSRTKHDVDM 506
Query: 402 RIG 404
RIG
Sbjct: 507 RIG 509
>L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein.
Length = 839
Score = 192 bits (469), Expect = 3e-48
Identities = 100/202 (49%), Positives = 143/202 (70%), Gaps = 11/202 (5%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+AI L + AL LH++Q + RLD++W QA EE+EDME ++ NR++L N+LP HVAQ
Sbjct: 509 VAILL-FSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQ 567
Query: 272 HFLCSD-KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
HFL S+ +N+D LY++ V VMFASIPNF++FY+EL+GNN GVECLRLLNEII
Sbjct: 568 HFLMSNPRNMD------LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEII 621
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGL--TNSTQDLVGY-RHVTAMADYALRLREQ 387
ADFDE++ ++ +K IEKIK+ G+TYMAA GL T+ T+ H++ +AD+A+ + +
Sbjct: 622 ADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDV 681
Query: 388 LQYVNEHSFNCFRIRIGKSCSP 409
L +N S+N F +R+G + P
Sbjct: 682 LDEINYQSYNDFVLRVGINVGP 703
Score = 124 bits (298), Expect = 1e-27
Identities = 58/82 (70%), Positives = 65/82 (79%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT+EV+ +L Y C
Sbjct: 698 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC 757
Query: 499 RGTVDVKGKGNMVTYFLEGVGD 520
RG V VKGKG M+TYFLEG D
Sbjct: 758 RGKVSVKGKGEMLTYFLEGRTD 779
Score = 47.6 bits (108), Expect = 2e-04
Identities = 19/45 (42%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+
Sbjct: 118 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITK 162
Score = 41.9 bits (94), Expect = 0.008
Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 287 ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIE 346
++Y ++ D+V ++FA I F+ L E ++LLNE+ FDE+ E +
Sbjct: 13 KIYIQRHDNVSILFADIVGFTG----LASQCTAQELVKLLNELFGKFDELATE---NHCR 65
Query: 347 KIKSTGATYMAASGLTNSTQD 367
+IK G Y SGLT D
Sbjct: 66 RIKILGDCYYCVSGLTQPKTD 86
>AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase 1
variant protein.
Length = 1045
Score = 192 bits (469), Expect = 3e-48
Identities = 100/202 (49%), Positives = 143/202 (70%), Gaps = 11/202 (5%)
Query: 212 IAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQ 271
+AI L + AL LH++Q + RLD++W QA EE+EDME ++ NR++L N+LP HVAQ
Sbjct: 776 VAILL-FSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQ 834
Query: 272 HFLCSD-KNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEII 330
HFL S+ +N+D LY++ V VMFASIPNF++FY+EL+GNN GVECLRLLNEII
Sbjct: 835 HFLMSNPRNMD------LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEII 888
Query: 331 ADFDEILAEEPFKYIEKIKSTGATYMAASGL--TNSTQDLVGY-RHVTAMADYALRLREQ 387
ADFDE++ ++ +K IEKIK+ G+TYMAA GL T+ T+ H++ +AD+A+ + +
Sbjct: 889 ADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDV 948
Query: 388 LQYVNEHSFNCFRIRIGKSCSP 409
L +N S+N F +R+G + P
Sbjct: 949 LDEINYQSYNDFVLRVGINVGP 970
Score = 89.8 bits (213), Expect = 3e-17
Identities = 40/51 (78%), Positives = 46/51 (90%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
GIN+GPVVAGVIGAR+PQYDIWGN VNVASRMDSTG+ IQVT+EV+ +L
Sbjct: 965 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLL 1015
Score = 53.6 bits (123), Expect = 2e-06
Identities = 41/163 (25%), Positives = 69/163 (42%), Gaps = 7/163 (4%)
Query: 205 WNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANI 264
W N + +G + + TE + R F+ E++ +E +LL ++
Sbjct: 198 WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSL 257
Query: 265 LPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLR 324
LP +VA + ++Y ++ D+V ++FA I F+ L E ++
Sbjct: 258 LPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTG----LASQCTAQELVK 313
Query: 325 LLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
LLNE+ FDE+ E + +IK G Y SGLT D
Sbjct: 314 LLNELFGKFDELATE---NHCRRIKILGDCYYCVSGLTQPKTD 353
Score = 47.6 bits (108), Expect = 2e-04
Identities = 19/45 (42%), Positives = 31/45 (68%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
G++ G V+ GV+G RK QYD+W N V +A+ M++ GL + +T+
Sbjct: 385 GLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITK 429
>D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein.
Length = 1088
Score = 175 bits (426), Expect = 5e-43
Identities = 88/195 (45%), Positives = 126/195 (64%), Gaps = 11/195 (5%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+ LL S+Q + RLD +WK + +E E+ E ++ NR LL N+LP HVA HF+ N
Sbjct: 816 ITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLN 875
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
++ YH+ D VCVMFAS+P+F FY E + N EG+ECLRLLNEIIADFDE+L +
Sbjct: 876 ------EDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLK 929
Query: 340 EPFKYIEKIKSTGATYMAASGLT----NSTQDLV-GYRHVTAMADYALRLREQLQYVNEH 394
F +EKIK+ G+TYMAA+GL+ + Q+L + H+ M ++++ L +L +N H
Sbjct: 930 PKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRH 989
Query: 395 SFNCFRIRIGKSCSP 409
SFN FR+R+G + P
Sbjct: 990 SFNSFRLRVGINHGP 1004
Score = 117 bits (282), Expect = 1e-25
Identities = 54/81 (66%), Positives = 62/81 (76%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GIN GPV+AGVIGARKPQYDIWGN VNVASRM+STG L IQVT+E IL GY
Sbjct: 995 RLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGY 1054
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
CRG ++VKGKG + TYF+
Sbjct: 1055 SCECRGLINVKGKGELRTYFV 1075
Score = 50.0 bits (114), Expect = 3e-05
Identities = 20/45 (44%), Positives = 33/45 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
GI+ G V+ GVIG RK QYD+W + V++A+RM++ G+ + +T+
Sbjct: 382 GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITE 426
>BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7
protein.
Length = 1080
Score = 175 bits (426), Expect = 5e-43
Identities = 88/195 (45%), Positives = 126/195 (64%), Gaps = 11/195 (5%)
Query: 220 VALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKN 279
+ LL S+Q + RLD +WK + +E E+ E ++ NR LL N+LP HVA HF+ N
Sbjct: 808 ITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLN 867
Query: 280 IDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAE 339
++ YH+ D VCVMFAS+P+F FY E + N EG+ECLRLLNEIIADFDE+L +
Sbjct: 868 ------EDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLK 921
Query: 340 EPFKYIEKIKSTGATYMAASGLT----NSTQDLV-GYRHVTAMADYALRLREQLQYVNEH 394
F +EKIK+ G+TYMAA+GL+ + Q+L + H+ M ++++ L +L +N H
Sbjct: 922 PKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRH 981
Query: 395 SFNCFRIRIGKSCSP 409
SFN FR+R+G + P
Sbjct: 982 SFNSFRLRVGINHGP 996
Score = 117 bits (282), Expect = 1e-25
Identities = 54/81 (66%), Positives = 62/81 (76%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ GIN GPV+AGVIGARKPQYDIWGN VNVASRM+STG L IQVT+E IL GY
Sbjct: 987 RLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGY 1046
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
CRG ++VKGKG + TYF+
Sbjct: 1047 SCECRGLINVKGKGELRTYFV 1067
Score = 50.0 bits (114), Expect = 3e-05
Identities = 20/45 (44%), Positives = 33/45 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
GI+ G V+ GVIG RK QYD+W + V++A+RM++ G+ + +T+
Sbjct: 374 GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITE 418
>BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 174 bits (423), Expect = 1e-42
Identities = 88/194 (45%), Positives = 128/194 (65%), Gaps = 11/194 (5%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+ ++
Sbjct: 803 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-- 860
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
++LYH+ + VCV+FAS+P+F EFY E N+EG+ECLRLLNEIIADFDE+L++
Sbjct: 861 ---NEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 917
Query: 342 FKYIEKIKSTGATYMAASGL-TNSTQDLV-----GYRHVTAMADYALRLREQLQYVNEHS 395
F +EKIK+ G+TYMAA+GL S QD H+ M ++A+ L +L +N+HS
Sbjct: 918 FSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHS 977
Query: 396 FNCFRIRIGKSCSP 409
FN FR+R+G + P
Sbjct: 978 FNNFRLRVGLNHGP 991
Score = 110 bits (265), Expect = 1e-23
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 982 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 1041
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 1042 TCYSRGVIKVKGKGQLCTYFL 1062
Score = 44.8 bits (101), Expect = 0.001
Identities = 18/52 (34%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + +T +L+
Sbjct: 368 GVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 419
Score = 38.3 bits (85), Expect = 0.096
Identities = 42/167 (25%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N + L VA + H E R F L + + ++ + + LL +ILP ++A
Sbjct: 177 NAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA 236
Query: 271 QHF---LCSDKNIDQFDAQE-------LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
+ + + Q E LY ++ V V++A I F+ E
Sbjct: 237 REMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPK---- 292
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
E + +LNE+ FD+I E +IK G Y SGL S D
Sbjct: 293 ELVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYCVSGLPLSLPD 336
>BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 174 bits (423), Expect = 1e-42
Identities = 88/194 (45%), Positives = 128/194 (65%), Gaps = 11/194 (5%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+ ++
Sbjct: 803 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-- 860
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
++LYH+ + VCV+FAS+P+F EFY E N+EG+ECLRLLNEIIADFDE+L++
Sbjct: 861 ---NEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 917
Query: 342 FKYIEKIKSTGATYMAASGL-TNSTQDLV-----GYRHVTAMADYALRLREQLQYVNEHS 395
F +EKIK+ G+TYMAA+GL S QD H+ M ++A+ L +L +N+HS
Sbjct: 918 FSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHS 977
Query: 396 FNCFRIRIGKSCSP 409
FN FR+R+G + P
Sbjct: 978 FNNFRLRVGLNHGP 991
Score = 110 bits (265), Expect = 1e-23
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 982 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 1041
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 1042 TCYSRGVIKVKGKGQLCTYFL 1062
Score = 44.8 bits (101), Expect = 0.001
Identities = 18/52 (34%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + +T +L+
Sbjct: 368 GVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 419
Score = 38.3 bits (85), Expect = 0.096
Identities = 42/167 (25%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N + L VA + H E R F L + + ++ + + LL +ILP ++A
Sbjct: 177 NAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA 236
Query: 271 QHF---LCSDKNIDQFDAQE-------LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
+ + + Q E LY ++ V V++A I F+ E
Sbjct: 237 REMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPK---- 292
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
E + +LNE+ FD+I E +IK G Y SGL S D
Sbjct: 293 ELVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYCVSGLPLSLPD 336
>AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens
cDNA FLJ32183 fis, clone PLACE6001886, highly similar to
ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). ).
Length = 506
Score = 174 bits (423), Expect = 1e-42
Identities = 88/194 (45%), Positives = 128/194 (65%), Gaps = 11/194 (5%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+ ++
Sbjct: 232 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-- 289
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
++LYH+ + VCV+FAS+P+F EFY E N+EG+ECLRLLNEIIADFDE+L++
Sbjct: 290 ---NEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 346
Query: 342 FKYIEKIKSTGATYMAASGL-TNSTQDLV-----GYRHVTAMADYALRLREQLQYVNEHS 395
F +EKIK+ G+TYMAA+GL S QD H+ M ++A+ L +L +N+HS
Sbjct: 347 FSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHS 406
Query: 396 FNCFRIRIGKSCSP 409
FN FR+R+G + P
Sbjct: 407 FNNFRLRVGLNHGP 420
Score = 110 bits (265), Expect = 1e-23
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 411 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 470
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 471 TCYSRGVIKVKGKGQLCTYFL 491
>AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type IV
protein.
Length = 1077
Score = 174 bits (423), Expect = 1e-42
Identities = 88/194 (45%), Positives = 128/194 (65%), Gaps = 11/194 (5%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNID 281
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+ ++
Sbjct: 803 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRR-- 860
Query: 282 QFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEP 341
++LYH+ + VCV+FAS+P+F EFY E N+EG+ECLRLLNEIIADFDE+L++
Sbjct: 861 ---NEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 917
Query: 342 FKYIEKIKSTGATYMAASGL-TNSTQDLV-----GYRHVTAMADYALRLREQLQYVNEHS 395
F +EKIK+ G+TYMAA+GL S QD H+ M ++A+ L +L +N+HS
Sbjct: 918 FSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHS 977
Query: 396 FNCFRIRIGKSCSP 409
FN FR+R+G + P
Sbjct: 978 FNNFRLRVGLNHGP 991
Score = 110 bits (265), Expect = 1e-23
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 982 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 1041
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 1042 TCYSRGVIKVKGKGQLCTYFL 1062
Score = 44.8 bits (101), Expect = 0.001
Identities = 18/52 (34%), Positives = 33/52 (63%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS 490
G++ G V+ GVIG +K QYD+W + V +A+ M++ G+ + +T +L+
Sbjct: 368 GVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 419
Score = 38.3 bits (85), Expect = 0.096
Identities = 42/167 (25%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N + L VA + H E R F L + + ++ + + LL +ILP ++A
Sbjct: 177 NAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA 236
Query: 271 QHF---LCSDKNIDQFDAQE-------LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGV 320
+ + + Q E LY ++ V V++A I F+ E
Sbjct: 237 REMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPK---- 292
Query: 321 ECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQD 367
E + +LNE+ FD+I E +IK G Y SGL S D
Sbjct: 293 ELVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYCVSGLPLSLPD 336
>AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1353
Score = 166 bits (403), Expect = 3e-40
Identities = 115/289 (39%), Positives = 157/289 (54%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D ++ ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNSNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 41.5 bits (93), Expect = 0.010
Identities = 15/54 (27%), Positives = 32/54 (59%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTRTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein.
Length = 1364
Score = 166 bits (403), Expect = 3e-40
Identities = 115/289 (39%), Positives = 157/289 (54%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 1008 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1057
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1058 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1114
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1115 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1159
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D ++ ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1160 ----VDDFNSNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1202
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1203 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1251
Score = 44.8 bits (101), Expect = 0.001
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 500 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 553
>DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 165 bits (400), Expect = 7e-40
Identities = 115/289 (39%), Positives = 156/289 (53%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D + ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNNNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 44.8 bits (101), Expect = 0.001
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 165 bits (400), Expect = 7e-40
Identities = 115/289 (39%), Positives = 156/289 (53%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D + ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNNNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 44.8 bits (101), Expect = 0.001
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type 9
protein.
Length = 1353
Score = 165 bits (400), Expect = 7e-40
Identities = 115/289 (39%), Positives = 156/289 (53%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D + ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNNNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 44.8 bits (101), Expect = 0.001
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1294
Score = 165 bits (400), Expect = 7e-40
Identities = 115/289 (39%), Positives = 156/289 (53%), Gaps = 46/289 (15%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
+++ E +YRL + ++A+ + ++ ++ LL NI+P HVA+ Q
Sbjct: 997 NREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE----------QLKV 1046
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDEILAEEPFKY 344
+ Y + DS V+FASI NFSEFY E EG G EC R+LNE+I DFDE+L++ +
Sbjct: 1047 SQTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSS 1103
Query: 345 IEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIG 404
IEKIK+ GATYMAASGL TA A +E LQ + E + R+
Sbjct: 1104 IEKIKTIGATYMAASGLN------------TAQAQDGSHPQEHLQILFEFAKEMMRV--- 1148
Query: 405 KSCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAV 464
D + ++RV G N GP+ AGVIG K YDIWG+ V
Sbjct: 1149 ----VDDFNNNMLWFNFKLRV-------------GFNHGPLTAGVIGTTKLLYDIWGDTV 1191
Query: 465 NVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTY 513
N+ASRMD+TG+ IQV++E Y +LS GY RGTV+VKGKG M TY
Sbjct: 1192 NIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 44.8 bits (101), Expect = 0.001
Identities = 16/54 (29%), Positives = 33/54 (61%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR 492
G++ G V+ G++G R+ ++D+W N VN+A+ M+ G+ + +++ L R
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542
>BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 protein.
Length = 1144
Score = 159 bits (386), Expect = 3e-38
Identities = 127/427 (29%), Positives = 199/427 (46%), Gaps = 43/427 (10%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAI 73
+Y+ E+++ FSCS VV +V++L T ++ I+++ +T + AI
Sbjct: 623 RYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI 682
Query: 74 DLKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
+ KL S + R T A L FI+V A ++ + + +Q G +N T
Sbjct: 683 FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM 741
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXX----XXX 184
E S P N + + + L V H +
Sbjct: 742 ETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDE 801
Query: 185 QEHLYYRNH------FYDYQ-HRCGLDWNQQWTNIAIALGATVALLL-------HSQQTE 230
+H +R H Q GL+ + + TV + L S+ E
Sbjct: 802 YDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVE 861
Query: 231 STYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYH 290
R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K +ELY
Sbjct: 862 KLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----DEELYS 916
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
+ D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I KIK+
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 351 TGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
G+TYMAASG+T + ++H+ +AD+AL +++ L +N SFN
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 398 CFRIRIG 404
F +RIG
Sbjct: 1037 NFMLRIG 1043
Score = 102 bits (245), Expect = 4e-21
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 1103 RGPIFVKGKGELLTFFLKG 1121
Score = 61.3 bits (142), Expect = 1e-08
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 229 NVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 289 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 344
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 345 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 395
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 396 EAISYVREKTKTGVDMRVG 414
Score = 48.8 bits (111), Expect = 7e-05
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 464
>AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cyclase
protein.
Length = 1144
Score = 159 bits (386), Expect = 3e-38
Identities = 127/427 (29%), Positives = 199/427 (46%), Gaps = 43/427 (10%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAI 73
+Y+ E+++ FSCS VV +V++L T ++ I+++ +T + AI
Sbjct: 623 RYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI 682
Query: 74 DLKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
+ KL S + R T A L FI+V A ++ + + +Q G +N T
Sbjct: 683 FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM 741
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXX----XXX 184
E S P N + + + L V H +
Sbjct: 742 ETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDE 801
Query: 185 QEHLYYRNH------FYDYQ-HRCGLDWNQQWTNIAIALGATVALLL-------HSQQTE 230
+H +R H Q GL+ + + TV + L S+ E
Sbjct: 802 YDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVE 861
Query: 231 STYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYH 290
R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K +ELY
Sbjct: 862 KLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----DEELYS 916
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
+ D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I KIK+
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 351 TGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
G+TYMAASG+T + ++H+ +AD+AL +++ L +N SFN
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 398 CFRIRIG 404
F +RIG
Sbjct: 1037 NFMLRIG 1043
Score = 102 bits (245), Expect = 4e-21
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 1103 RGPIFVKGKGELLTFFLKG 1121
Score = 61.3 bits (142), Expect = 1e-08
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 229 NVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 289 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 344
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 345 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 395
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 396 EAISYVREKTKTGVDMRVG 414
Score = 48.8 bits (111), Expect = 7e-05
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 464
>AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein.
Length = 1144
Score = 159 bits (386), Expect = 3e-38
Identities = 127/427 (29%), Positives = 199/427 (46%), Gaps = 43/427 (10%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAI 73
+Y+ E+++ FSCS VV +V++L T ++ I+++ +T + AI
Sbjct: 623 RYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI 682
Query: 74 DLKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
+ KL S + R T A L FI+V A ++ + + +Q G +N T
Sbjct: 683 FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM 741
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXX----XXX 184
E S P N + + + L V H +
Sbjct: 742 ETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDE 801
Query: 185 QEHLYYRNH------FYDYQ-HRCGLDWNQQWTNIAIALGATVALLL-------HSQQTE 230
+H +R H Q GL+ + + TV + L S+ E
Sbjct: 802 YDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVE 861
Query: 231 STYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYH 290
R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K +ELY
Sbjct: 862 KLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----DEELYS 916
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
+ D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I KIK+
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 351 TGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
G+TYMAASG+T + ++H+ +AD+AL +++ L +N SFN
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 398 CFRIRIG 404
F +RIG
Sbjct: 1037 NFMLRIG 1043
Score = 102 bits (245), Expect = 4e-21
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 1103 RGPIFVKGKGELLTFFLKG 1121
Score = 61.3 bits (142), Expect = 1e-08
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 229 NVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 289 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 344
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 345 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 395
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 396 EAISYVREKTKTGVDMRVG 414
Score = 48.8 bits (111), Expect = 7e-05
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 464
>AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein.
Length = 933
Score = 159 bits (386), Expect = 3e-38
Identities = 127/427 (29%), Positives = 199/427 (46%), Gaps = 43/427 (10%)
Query: 15 QYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYL-IFAI 73
+Y+ E+++ FSCS VV +V++L T ++ I+++ +T + AI
Sbjct: 412 RYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI 471
Query: 74 DLKFAGGKLKRISKRVHNNR----TLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVP 129
+ KL S + R T A L FI+V A ++ + + +Q G +N T
Sbjct: 472 FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM 530
Query: 130 SYENSGGNCPYDMNEHYLQVTLMAMFLCAV-HQIXXXXXXXXXXXXXXXXXXX----XXX 184
E S P N + + + L V H +
Sbjct: 531 ETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDE 590
Query: 185 QEHLYYRNH------FYDYQ-HRCGLDWNQQWTNIAIALGATVALLL-------HSQQTE 230
+H +R H Q GL+ + + TV + L S+ E
Sbjct: 591 YDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVE 650
Query: 231 STYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYH 290
R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K +ELY
Sbjct: 651 KLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----DEELYS 705
Query: 291 EQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKS 350
+ D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I KIK+
Sbjct: 706 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 765
Query: 351 TGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFN 397
G+TYMAASG+T + ++H+ +AD+AL +++ L +N SFN
Sbjct: 766 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 825
Query: 398 CFRIRIG 404
F +RIG
Sbjct: 826 NFMLRIG 832
Score = 102 bits (245), Expect = 4e-21
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 832 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 891
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 892 RGPIFVKGKGELLTFFLKG 910
Score = 61.3 bits (142), Expect = 1e-08
Identities = 54/199 (27%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 211 NIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVA 270
N+ + L A ++ + +R F+ Q+ E K ++E L+ +ILP+HVA
Sbjct: 18 NVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 77
Query: 271 QHFLCS-DKNIDQFDAQE---LYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLL 326
L K+ Q D Q+ +Y + ++V ++FA I F+ +L E ++LL
Sbjct: 78 DEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT----QLSSACSAQELVKLL 133
Query: 327 NEIIADFDEILAEEPFKYIE-KIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLR 385
NE+ A FD++ A KY + +IK G Y GL + +D H L +
Sbjct: 134 NELFARFDKLAA----KYHQLRIKILGDCYYCICGLPDYRED-----HAVCSILMGLAMV 184
Query: 386 EQLQYVNEHSFNCFRIRIG 404
E + YV E + +R+G
Sbjct: 185 EAISYVREKTKTGVDMRVG 203
Score = 48.8 bits (111), Expect = 7e-05
Identities = 18/51 (35%), Positives = 33/51 (64%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL 489
G++ G V+ GV+G ++ QYD+W V VA++M++ G+ + ++Q D L
Sbjct: 203 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 253
>AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens
cDNA PSEC0115 fis, clone PLACE1000086, highly similar to
ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1). ).
Length = 378
Score = 158 bits (383), Expect = 7e-38
Identities = 81/192 (42%), Positives = 119/192 (61%), Gaps = 18/192 (9%)
Query: 226 SQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDA 285
S+ E R F+WK++ +++KE + ++ +N L+ N+LPEHVA+HFL S K
Sbjct: 91 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR-----D 145
Query: 286 QELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYI 345
+ELY + D + VMFAS+PNF++FY E NN G+ECLR LNEII+DFD +L F+ I
Sbjct: 146 EELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVI 205
Query: 346 EKIKSTGATYMAASGLT-------------NSTQDLVGYRHVTAMADYALRLREQLQYVN 392
KIK+ G+TYMAASG+T + ++H+ +AD+AL +++ L +N
Sbjct: 206 TKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNIN 265
Query: 393 EHSFNCFRIRIG 404
SFN F +RIG
Sbjct: 266 NQSFNNFMLRIG 277
Score = 102 bits (245), Expect = 4e-21
Identities = 47/79 (59%), Positives = 61/79 (77%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
G+N G V+AGVIGARKP YDIWGN VNVASRM+STG++ +IQV +E IL G++
Sbjct: 277 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 336
Query: 499 RGTVDVKGKGNMVTYFLEG 517
RG + VKGKG ++T+FL+G
Sbjct: 337 RGPIFVKGKGELLTFFLKG 355
>BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein.
Length = 130
Score = 110 bits (265), Expect = 1e-23
Identities = 52/81 (64%), Positives = 61/81 (75%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGY 494
R+ G+N GPVVAGVIGA+KPQYDIWGN VNVASRM+STG+L IQVT+E L + GY
Sbjct: 35 RLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGY 94
Query: 495 KLRCRGTVDVKGKGNMVTYFL 515
RG + VKGKG + TYFL
Sbjct: 95 TCYSRGVIKVKGKGQLCTYFL 115
Score = 39.5 bits (88), Expect = 0.042
Identities = 15/37 (40%), Positives = 25/37 (67%)
Query: 373 HVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSP 409
H+ M ++A+ L +L +N+HSFN FR+R+G + P
Sbjct: 8 HLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGP 44
>AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclase
subunit beta 2 protein.
Length = 617
Score = 82.2 bits (194), Expect = 6e-15
Identities = 47/126 (37%), Positives = 72/126 (57%), Gaps = 15/126 (11%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRC 498
GI+ GPV+A V+G + P+Y ++G+ VN ASRM+S GL + + ++ Y L +G+K+
Sbjct: 487 GIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQGFKIIE 546
Query: 499 RGTVDVKGKGNMVTYFLEGVGDSIPDDIYNN--------------PIPSTSSEGAVPPR- 543
RG ++VKGKG M TYFL ++ D+I +P+T +G+V P
Sbjct: 547 RGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQGSVQPSC 606
Query: 544 PEHRPL 549
PEH L
Sbjct: 607 PEHSSL 612
>BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein.
Length = 618
Score = 77.8 bits (183), Expect = 1e-13
Identities = 42/99 (42%), Positives = 60/99 (60%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ G++ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 514 SFRIRHRPHDQL---RLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKI 570
Query: 480 QVTQEVYDILSARG-YKLRCRGTVDVKGKGNMVTYFLEG 517
V+ D L G ++L RG V++KGKG M TY+L G
Sbjct: 571 HVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLG 609
>AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide
receptor B/guanylate cyclase B (atrionatriuretic peptide
re protein.
Length = 1047
Score = 77.8 bits (183), Expect = 1e-13
Identities = 42/99 (42%), Positives = 60/99 (60%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ G++ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 943 SFRIRHRPHDQL---RLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKI 999
Query: 480 QVTQEVYDILSARG-YKLRCRGTVDVKGKGNMVTYFLEG 517
V+ D L G ++L RG V++KGKG M TY+L G
Sbjct: 1000 HVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLG 1038
>AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic peptide
Btype receptor protein.
Length = 1047
Score = 77.8 bits (183), Expect = 1e-13
Identities = 42/99 (42%), Positives = 60/99 (60%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ G++ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 943 SFRIRHRPHDQL---RLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKI 999
Query: 480 QVTQEVYDILSARG-YKLRCRGTVDVKGKGNMVTYFLEG 517
V+ D L G ++L RG V++KGKG M TY+L G
Sbjct: 1000 HVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLG 1038
>L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein.
Length = 1108
Score = 76.6 bits (180), Expect = 3e-13
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 2/85 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--AR 492
R+ G++ GPVVAGV+G P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 978 RIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG 517
GY++ RG ++KGKG T++L G
Sbjct: 1038 GYEVELRGRTELKGKGTEETFWLIG 1062
Score = 40.7 bits (91), Expect = 0.018
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + KLL +LP VA+ L ++ E D V + F+ I
Sbjct: 841 ERTEELEIEKQKTEKLLTQMLPPSVAES-LKKGCTVEP--------EGFDLVTLYFSDIV 891
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 892 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPKR 944
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 945 N----GSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGP 987
>AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F,
retinal protein.
Length = 1108
Score = 76.6 bits (180), Expect = 3e-13
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 2/85 (2%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILS--AR 492
R+ G++ GPVVAGV+G P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 978 RIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
Query: 493 GYKLRCRGTVDVKGKGNMVTYFLEG 517
GY++ RG ++KGKG T++L G
Sbjct: 1038 GYEVELRGRTELKGKGTEETFWLIG 1062
Score = 40.7 bits (91), Expect = 0.018
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + KLL +LP VA+ L ++ E D V + F+ I
Sbjct: 841 ERTEELEIEKQKTEKLLTQMLPPSVAES-LKKGCTVEP--------EGFDLVTLYFSDIV 891
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 892 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPKR 944
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 945 N----GSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGP 987
>X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein (AA
-32 to 1029) protein.
Length = 1061
Score = 75.4 bits (177), Expect = 7e-13
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 75.4 bits (177), Expect = 7e-13
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 75.4 bits (177), Expect = 7e-13
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide receptor
A protein.
Length = 1061
Score = 75.4 bits (177), Expect = 7e-13
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A type
receptor protein.
Length = 1061
Score = 75.4 bits (177), Expect = 7e-13
Identities = 41/99 (41%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 958 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1014
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVTYFLEG 517
++ E +L G++L RG V++KGKG + TY+L G
Sbjct: 1015 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
>M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 74.1 bits (174), Expect = 2e-12
Identities = 44/104 (42%), Positives = 61/104 (58%), Gaps = 5/104 (4%)
Query: 416 SANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL 475
SA T R+R P + R+ G++ GP VAGV+G P+Y ++G+ VN ASRM+STGL
Sbjct: 958 SAVGTFRMRHMPE---VPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1014
Query: 476 LDHIQVTQEVYDILSA--RGYKLRCRGTVDVKGKGNMVTYFLEG 517
I V IL A GY++ RG ++KGKG T++L G
Sbjct: 1015 PYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
Score = 39.1 bits (87), Expect = 0.055
Identities = 44/167 (26%), Positives = 71/167 (42%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + +LL +LP VA+ + Y EQ V + F+ I
Sbjct: 837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP------VEPEYFEQ---VTLYFSDIV 887
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 888 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPQR 940
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 941 N----GQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGP 983
>AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 74.1 bits (174), Expect = 2e-12
Identities = 44/104 (42%), Positives = 61/104 (58%), Gaps = 5/104 (4%)
Query: 416 SANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGL 475
SA T R+R P + R+ G++ GP VAGV+G P+Y ++G+ VN ASRM+STGL
Sbjct: 958 SAVGTFRMRHMPE---VPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1014
Query: 476 LDHIQVTQEVYDILSA--RGYKLRCRGTVDVKGKGNMVTYFLEG 517
I V IL A GY++ RG ++KGKG T++L G
Sbjct: 1015 PYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
Score = 39.1 bits (87), Expect = 0.055
Identities = 44/167 (26%), Positives = 71/167 (42%), Gaps = 22/167 (13%)
Query: 245 EEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIP 304
E E++E + +LL +LP VA+ + Y EQ V + F+ I
Sbjct: 837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP------VEPEYFEQ---VTLYFSDIV 887
Query: 305 NFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNS 364
F+ + +E +E + LLN++ FD I+ + K+++ G YM ASGL
Sbjct: 888 GFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPQR 940
Query: 365 TQDLVGYRHVTAMADYALRLREQL-QYVNEHSFNC-FRIRIGKSCSP 409
G RH +A+ +L + + + H RIRIG P
Sbjct: 941 N----GQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGP 983
>S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled
enterotoxin receptor protein.
Length = 1073
Score = 69.7 bits (163), Expect = 3e-11
Identities = 39/98 (39%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR--GYKL 496
G++ GP AGV+G + P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 922 GVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLY 981
Query: 497 RCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPST 534
RG +KG+GN TY+L G + D +N P P T
Sbjct: 982 EVRGETYLKGRGNETTYWLTG----MKDQKFNLPTPPT 1015
Score = 33.5 bits (73), Expect = 2.7
Identities = 46/166 (27%), Positives = 67/166 (40%), Gaps = 20/166 (12%)
Query: 223 LLHSQQTESTYRLDFIWKLQA---NEEKEDMEHLQAYNRKL-LANILPEHVAQHFLCSDK 278
L H Q+ ES Y I +LQ N E E Q Y + A+ L + +
Sbjct: 751 LFHDQKNES-YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSL 809
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
F ELY E V + F+ I F+ + +E + +LN+I FD I+
Sbjct: 810 KEKGFVEPELYEE----VTIYFSDIVGFTTICKY----STPMEVVDMLNDIYKSFDHIVD 861
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRL 384
+ K+++ G YM ASGL G RH +A AL +
Sbjct: 862 HHD---VYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALEI 900
>M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin
receptor protein.
Length = 1073
Score = 69.7 bits (163), Expect = 3e-11
Identities = 39/98 (39%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSAR--GYKL 496
G++ GP AGV+G + P+Y ++G+ VN ASRM+STGL I V+ IL +
Sbjct: 922 GVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLY 981
Query: 497 RCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPST 534
RG +KG+GN TY+L G + D +N P P T
Sbjct: 982 EVRGETYLKGRGNETTYWLTG----MKDQKFNLPTPPT 1015
Score = 33.5 bits (73), Expect = 2.7
Identities = 46/166 (27%), Positives = 67/166 (40%), Gaps = 20/166 (12%)
Query: 223 LLHSQQTESTYRLDFIWKLQA---NEEKEDMEHLQAYNRKL-LANILPEHVAQHFLCSDK 278
L H Q+ ES Y I +LQ N E E Q Y + A+ L + +
Sbjct: 751 LFHDQKNES-YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSL 809
Query: 279 NIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILA 338
F ELY E V + F+ I F+ + +E + +LN+I FD I+
Sbjct: 810 KEKGFVEPELYEE----VTIYFSDIVGFTTICKY----STPMEVVDMLNDIYKSFDHIVD 861
Query: 339 EEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRL 384
+ K+++ G YM ASGL G RH +A AL +
Sbjct: 862 HHD---VYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALEI 900
>S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptide
receptor guanylate protein.
Length = 415
Score = 69.3 bits (162), Expect = 4e-11
Identities = 38/94 (40%), Positives = 57/94 (60%), Gaps = 4/94 (4%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 325 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 381
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGNMVT 512
++ E +L G++L RG V++KGKG + T
Sbjct: 382 HLSSETKAVLEEFGGFELELRGDVEMKGKGKVRT 415
>AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide
receptor A/guanylate cyclase A (atrionatriuretic peptide
re protein.
Length = 255
Score = 63.7 bits (148), Expect = 2e-09
Identities = 43/118 (36%), Positives = 65/118 (55%), Gaps = 10/118 (8%)
Query: 420 TLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHI 479
+ R+R P L R+ GI+ GPV AGV+G + P+Y ++G+ VN ASRM+S G I
Sbjct: 139 SFRIRHRPQEQL---RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 195
Query: 480 QVTQEVYDILSA-RGYKLRCRGTVDVKGKGN---MVTYFLEGVGDSIPDDIYN-NPIP 532
++ E +L G++L RG V++K +G + T++ G S P N PIP
Sbjct: 196 HLSSETKAVLEEFGGFELELRGDVEMKVEGEASALPTFW--GPRGSYPSQAANATPIP 251
>X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein.
Length = 619
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/87 (40%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL----- 489
++ GI+ G VV GVIG R P+Y ++GN VN+ SR ++TG I V++ Y L
Sbjct: 518 QITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPEN 577
Query: 490 SARGYKLRCRGTVDVKGKGN-MVTYFL 515
S + L RG V +KGK M +FL
Sbjct: 578 SDPQFHLEHRGPVSMKGKKEPMQVWFL 604
Score = 41.1 bits (92), Expect = 0.014
Identities = 18/68 (26%), Positives = 35/68 (51%)
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
D+V ++F+ I F+ F + ++ + LLN++ FD + ++ K+++ G
Sbjct: 418 DNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGD 477
Query: 354 TYMAASGL 361
YM SGL
Sbjct: 478 KYMTVSGL 485
>BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1,
soluble, beta 3 protein.
Length = 619
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/87 (40%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL----- 489
++ GI+ G VV GVIG R P+Y ++GN VN+ SR ++TG I V++ Y L
Sbjct: 518 QITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPEN 577
Query: 490 SARGYKLRCRGTVDVKGKGN-MVTYFL 515
S + L RG V +KGK M +FL
Sbjct: 578 SDPQFHLEHRGPVSMKGKKEPMQVWFL 604
Score = 41.1 bits (92), Expect = 0.014
Identities = 18/68 (26%), Positives = 35/68 (51%)
Query: 294 DSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGA 353
D+V ++F+ I F+ F + ++ + LLN++ FD + ++ K+++ G
Sbjct: 418 DNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGD 477
Query: 354 TYMAASGL 361
YM SGL
Sbjct: 478 KYMTVSGL 485
>AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cyclase
beta-1 subunit protein.
Length = 586
Score = 57.6 bits (133), Expect = 1e-07
Identities = 35/87 (40%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 435 RVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDIL----- 489
++ GI+ G VV GVIG R P+Y ++GN VN+ SR ++TG I V++ Y L
Sbjct: 485 QITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPEN 544
Query: 490 SARGYKLRCRGTVDVKGKGN-MVTYFL 515
S + L RG V +KGK M +FL
Sbjct: 545 SDPQFHLEHRGPVSMKGKKEPMQVWFL 571
Score = 32.3 bits (70), Expect = 6.3
Identities = 15/59 (25%), Positives = 28/59 (47%)
Query: 303 IPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGL 361
I F+ F + ++ + LLN++ FD + ++ K+++ G YM SGL
Sbjct: 394 IVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGL 452
>Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of soluble
guanylyl cyclase protein.
Length = 763
Score = 52.8 bits (121), Expect = 4e-06
Identities = 61/252 (24%), Positives = 108/252 (42%), Gaps = 27/252 (10%)
Query: 240 KLQANEEK--EDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVC 297
KL+A E+ + +E + LL +I P VAQ + Q++ + D V
Sbjct: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQL---------WQGQQVQARKFDDVT 521
Query: 298 VMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMA 357
++F+ I F+ + ++ + +LNE+ FD F I K+++ G Y
Sbjct: 522 MLFSDIVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCV 574
Query: 358 ASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGKSCSPSDATASSA 417
A+GL + L + + MA + L E++ + R + S S
Sbjct: 575 AAGLHRKS--LCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQ 632
Query: 418 NCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLD 477
+ + L ++ GI+ G V+AGV+G R P+Y ++GN V +AS+ +S
Sbjct: 633 H-------QSETDLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPR 685
Query: 478 HIQVTQEVYDIL 489
I V+ Y +L
Sbjct: 686 RINVSPTTYQLL 697
>AK131333-1|BAD18492.1| 174|Homo sapiens 9. protein.
Length = 174
Score = 52.4 bits (120), Expect = 6e-06
Identities = 23/53 (43%), Positives = 35/53 (66%)
Query: 222 LLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFL 274
LL+ ++Q E RLDF+WK + +E+E+ E ++ R LL N+LP HVA F+
Sbjct: 103 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFI 155
>BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein.
Length = 433
Score = 50.0 bits (114), Expect = 3e-05
Identities = 20/45 (44%), Positives = 33/45 (73%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQ 483
GI+ G V+ GVIG RK QYD+W + V++A+RM++ G+ + +T+
Sbjct: 374 GIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITE 418
>AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens
cDNA FLJ44504 fis, clone UTERU3001240, highly similar
to Adenylate cyclase, type IV (EC 4.6.1.1). ).
Length = 419
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 406 SCSPSDATASSANCTLRVRVEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVN 465
SCS S + ASS ++R G + +R G++ G V+ GVIG +K QYD+W + V
Sbjct: 32 SCSMS-SLASSTRLPRKLRAATGVDINMR---VGVHSGSVLCGVIGLQKWQYDVWSHDVT 87
Query: 466 VASRMDSTGLLDHIQVTQEVYDILS 490
+A+ M++ G+ + +T +L+
Sbjct: 88 LANHMEAGGVPGRVHITGATLALLA 112
>X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble
guanylyl cyclase protein.
Length = 732
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
P G I R+ GI+ G V+AGV+G R P+Y ++GN V +AS+ +S I V+ Y
Sbjct: 606 PDGRPIQMRI--GIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTY 663
Query: 487 DIL 489
+L
Sbjct: 664 QLL 666
>BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
P G I R+ GI+ G V+AGV+G R P+Y ++GN V +AS+ +S I V+ Y
Sbjct: 606 PDGRPIQMRI--GIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTY 663
Query: 487 DIL 489
+L
Sbjct: 664 QLL 666
>BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 427 PGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVY 486
P G I R+ GI+ G V+AGV+G R P+Y ++GN V +AS+ +S I V+ Y
Sbjct: 606 PDGRPIQMRI--GIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTY 663
Query: 487 DIL 489
+L
Sbjct: 664 QLL 666
>U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V
protein.
Length = 105
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 439 GINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLR- 497
GI+ G V GV+G RK Q+D+W N V +A+ M++ G I +T+ + L+ Y++
Sbjct: 5 GIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEVEP 63
Query: 498 -CRGTVDVKGKGNMVTYFL 515
C G + K + + FL
Sbjct: 64 GCGGERNAYLKEHSIETFL 82
>Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase
protein.
Length = 690
Score = 43.6 bits (98), Expect = 0.003
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ P G I R+ G++ G V AGV+G + P+Y ++GN V +A++ +S + I V+
Sbjct: 564 MSPHGEPIKMRI--GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 621
Query: 485 VYDIL 489
Y +L
Sbjct: 622 TYRLL 626
>X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein.
Length = 717
Score = 43.6 bits (98), Expect = 0.003
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ P G I R+ G++ G V AGV+G + P+Y ++GN V +A++ +S + I V+
Sbjct: 561 MSPHGEPIKMRI--GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 618
Query: 485 VYDIL 489
Y +L
Sbjct: 619 TYRLL 623
>U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 690
Score = 43.6 bits (98), Expect = 0.003
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ P G I R+ G++ G V AGV+G + P+Y ++GN V +A++ +S + I V+
Sbjct: 564 MSPHGEPIKMRI--GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 621
Query: 485 VYDIL 489
Y +L
Sbjct: 622 TYRLL 626
>BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein.
Length = 690
Score = 43.6 bits (98), Expect = 0.003
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ P G I R+ G++ G V AGV+G + P+Y ++GN V +A++ +S + I V+
Sbjct: 564 MSPHGEPIKMRI--GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 621
Query: 485 VYDIL 489
Y +L
Sbjct: 622 TYRLL 626
>AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 564
Score = 43.6 bits (98), Expect = 0.003
Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 425 VEPGGALIVRRVPAGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQE 484
+ P G I R+ G++ G V AGV+G + P+Y ++GN V +A++ +S + I V+
Sbjct: 438 MSPHGEPIKMRI--GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 495
Query: 485 VYDIL 489
Y +L
Sbjct: 496 TYRLL 500
>AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein.
Length = 105
Score = 41.9 bits (94), Expect = 0.008
Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 287 ELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIE 346
++Y ++ D+V ++FA I F+ L E ++LLNE+ FDE+ E +
Sbjct: 15 KIYIQRHDNVSILFADIVGFTG----LASQCTAQELVKLLNELFGKFDELATE---NHCR 67
Query: 347 KIKSTGATYMAASGLTNSTQD 367
+IK G Y SGLT D
Sbjct: 68 RIKILGDCYYCVSGLTQPKTD 88
>L26921-1|AAA60366.1| 80|Homo sapiens guanyl cyclase protein.
Length = 80
Score = 36.3 bits (80), Expect = 0.39
Identities = 21/50 (42%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Query: 470 MDSTGLLDHIQVTQEVYDILSA--RGYKLRCRGTVDVKGKGNMVTYFLEG 517
M+STGL I V IL A GY++ RG ++KGKG T++L G
Sbjct: 1 MESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 50
>AL590452-8|CAH72528.1| 2240|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2240
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1819 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1878
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1879 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 1918
>AL590452-4|CAH72524.1| 2346|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2346
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1925 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1984
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1985 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
>AL590452-3|CAH72523.1| 2362|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2362
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1925 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1984
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1985 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
>AL138796-7|CAI22827.1| 2240|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2240
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1819 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1878
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1879 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 1918
>AL138796-4|CAI22824.1| 2346|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2346
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1925 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1984
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1985 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
>AL138796-3|CAI22823.1| 2362|Homo sapiens phosphodiesterase 4D
interacting protein (myomegalin) protein.
Length = 2362
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1925 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1984
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1985 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
>AB007923-1|BAA32299.2| 2296|Homo sapiens KIAA0454 protein protein.
Length = 2296
Score = 32.3 bits (70), Expect = 6.3
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 225 HSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANIL-PEHVAQHFLCSDKNIDQF 283
HSQ+TES + E ++++EH + ++LL ++ + HF ++ +
Sbjct: 1875 HSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEN 1934
Query: 284 DAQ-----ELYHEQCDSVCVMFASIPNFSEFYVELEGNNE 318
D++ L +QC+ +F S+ + + Y L GN++
Sbjct: 1935 DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 1974
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.322 0.136 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 94,607,304
Number of Sequences: 224733
Number of extensions: 3704492
Number of successful extensions: 9173
Number of sequences better than 10.0: 75
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 8902
Number of HSP's gapped (non-prelim): 177
length of query: 731
length of database: 73,234,838
effective HSP length: 95
effective length of query: 636
effective length of database: 51,885,203
effective search space: 32998989108
effective search space used: 32998989108
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 69 (31.9 bits)
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