Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002064-TA|BGIBMGA002064-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(566 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|... 533 e-150
UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB... 522 e-147
UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41; Deutero... 414 e-114
UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia califor... 385 e-105
UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate ... 370 e-101
UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:... 367 e-100
UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella ve... 363 9e-99
UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC 4.6... 357 6e-97
UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1) (... 354 3e-96
UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep: ... 343 6e-93
UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1) (... 339 9e-92
UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whol... 337 4e-91
UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome sh... 328 3e-88
UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl c... 326 1e-87
UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC 4.6... 322 1e-86
UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA... 317 4e-85
UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2; Caenor... 308 3e-82
UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia califor... 307 5e-82
UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2; Sophopho... 297 4e-79
UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whol... 296 9e-79
UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome s... 295 2e-78
UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|R... 295 2e-78
UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to ENSANGP000... 295 2e-78
UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl c... 293 8e-78
UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate ... 291 3e-77
UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|... 291 4e-77
UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate ... 290 6e-77
UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gamb... 290 6e-77
UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep: ... 289 2e-76
UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome s... 285 2e-75
UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella ve... 285 2e-75
UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC 4.6... 283 9e-75
UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC 4.6... 281 4e-74
UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain aden... 277 4e-73
UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73; Euteleo... 274 5e-72
UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora... 272 2e-71
UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebr... 269 1e-70
UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 269 1e-70
UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2; Apoc... 268 3e-70
UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate ... 264 6e-69
UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7; D... 259 2e-67
UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whol... 255 2e-66
UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6... 255 3e-66
UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2; Xenopu... 250 8e-65
UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate ... 239 1e-61
UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2; Caenor... 227 6e-58
UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella ve... 215 3e-54
UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,... 207 5e-52
UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole... 207 5e-52
UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG571... 206 9e-52
UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate ... 202 1e-50
UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate ... 200 1e-49
UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl c... 199 1e-49
UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:... 198 2e-49
UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29; Euteleo... 198 2e-49
UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4; Sop... 195 2e-48
UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p... 194 4e-48
UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 194 5e-48
UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome s... 187 8e-46
UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1;... 184 6e-45
UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome sho... 178 3e-43
UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep: CG3230... 168 4e-40
UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|... 155 4e-36
UniRef50_Q9JK77 Cluster: Adenylyl cyclase 3; n=7; Euteleostomi|R... 153 2e-35
UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila melanogaste... 153 2e-35
UniRef50_Q5DTS7 Cluster: MKIAA4004 protein; n=2; Murinae|Rep: MK... 151 4e-35
UniRef50_Q5BXY8 Cluster: SJCHGC07735 protein; n=1; Schistosoma j... 142 2e-32
UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 138 5e-31
UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC ... 137 6e-31
UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; ... 137 6e-31
UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4; Burkh... 136 1e-30
UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 136 1e-30
UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 135 3e-30
UniRef50_UPI00005A96A3 Cluster: PREDICTED: similar to adenylate ... 134 8e-30
UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 133 1e-29
UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 132 2e-29
UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, fami... 130 1e-28
UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1; Ralst... 130 1e-28
UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 127 9e-28
UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular organis... 126 1e-27
UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=... 124 8e-27
UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1; L... 124 8e-27
UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3; Oscillatoriales... 122 2e-26
UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 122 2e-26
UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15; Mycobacterium|... 122 2e-26
UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1; ... 122 3e-26
UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 120 1e-25
UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 120 1e-25
UniRef50_UPI0000E4A5D0 Cluster: PREDICTED: similar to adenylyl c... 118 3e-25
UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulat... 118 4e-25
UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2; Sinor... 118 5e-25
UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1; Janna... 117 7e-25
UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1; L... 116 1e-24
UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalyt... 115 4e-24
UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|R... 114 5e-24
UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 114 5e-24
UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, w... 114 5e-24
UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira inte... 114 7e-24
UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, w... 114 7e-24
UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome sh... 113 9e-24
UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; ... 113 9e-24
UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n... 113 9e-24
UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 113 9e-24
UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12; Co... 113 9e-24
UniRef50_A0BG69 Cluster: Chromosome undetermined scaffold_105, w... 113 1e-23
UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalyt... 112 3e-23
UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella ve... 112 3e-23
UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase ... 111 6e-23
UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, wh... 111 6e-23
UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep: C... 110 8e-23
UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella ve... 110 8e-23
UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, wh... 110 1e-22
UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira inte... 109 1e-22
UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 109 1e-22
UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, wh... 109 1e-22
UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|... 109 2e-22
UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, wh... 109 2e-22
UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Parame... 109 3e-22
UniRef50_UPI0000E47CE0 Cluster: PREDICTED: hypothetical protein;... 108 3e-22
UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera glyc... 108 3e-22
UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1; Mi... 108 4e-22
UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2; Cul... 107 6e-22
UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase ... 107 8e-22
UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, wh... 107 8e-22
UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta proteobac... 107 1e-21
UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla mar... 107 1e-21
UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena pyri... 106 2e-21
UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalyt... 106 2e-21
UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalyt... 106 2e-21
UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1; Pseud... 105 2e-21
UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29... 105 2e-21
UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to ENSANGP000... 105 3e-21
UniRef50_UPI00006CEB6E Cluster: Adenylate and Guanylate cyclase ... 104 5e-21
UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase ... 104 5e-21
UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase ... 104 5e-21
UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 104 5e-21
UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla mar... 104 5e-21
UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1; Chl... 104 5e-21
UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Parame... 104 5e-21
UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble gu... 104 7e-21
UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, w... 104 7e-21
UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha... 104 7e-21
UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep: Gu... 103 1e-20
UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Parame... 103 1e-20
UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep: Gu... 103 1e-20
UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 103 2e-20
UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|... 102 2e-20
UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 102 2e-20
UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit... 102 3e-20
UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA ... 102 3e-20
UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, wh... 102 3e-20
UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriureti... 101 4e-20
UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subuni... 101 4e-20
UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulat... 101 5e-20
UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalyt... 101 5e-20
UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha... 101 5e-20
UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2; ... 101 5e-20
UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n... 101 7e-20
UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla mar... 101 7e-20
UniRef50_A0LXB4 Cluster: Secreted protein containing adenylate/g... 101 7e-20
UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7; Endopterygot... 101 7e-20
UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=... 101 7e-20
UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha... 101 7e-20
UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2; Caeno... 100 9e-20
UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalyt... 100 9e-20
UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, wh... 100 9e-20
UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, w... 100 9e-20
UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep... 99 2e-19
UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium falci... 100 2e-19
UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus japon... 100 2e-19
UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylat... 100 2e-19
UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A p... 100 2e-19
UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase ... 99 3e-19
UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n... 99 3e-19
UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-... 99 3e-19
UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to ENSANGP000... 99 4e-19
UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to ENSANGP000... 99 4e-19
UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta proteobac... 98 5e-19
UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-... 98 5e-19
UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalyt... 98 6e-19
UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n... 98 6e-19
UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to ENSANGP000... 97 8e-19
UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA;... 97 8e-19
UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1; Flavo... 97 8e-19
UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP045... 97 1e-18
UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane g... 96 2e-18
UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n... 96 2e-18
UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmo... 96 2e-18
UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|... 96 3e-18
UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep: ... 96 3e-18
UniRef50_UPI00006D0DB9 Cluster: Sodium/calcium exchanger protein... 95 3e-18
UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella ve... 95 3e-18
UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor t... 95 4e-18
UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor t... 95 4e-18
UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla mar... 95 4e-18
UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A; ... 95 6e-18
UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theile... 95 6e-18
UniRef50_Q18628 Cluster: Putative uncharacterized protein acy-3;... 95 6e-18
UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1; M... 94 8e-18
UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1 p... 94 8e-18
UniRef50_P16065 Cluster: Speract receptor precursor; n=7; Euechi... 94 1e-17
UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 93 1e-17
UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 93 1e-17
UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate ... 93 2e-17
UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriureti... 93 2e-17
UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 93 2e-17
UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 93 2e-17
UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 93 2e-17
UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|R... 93 2e-17
UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:... 93 2e-17
UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella ve... 92 3e-17
UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precur... 92 3e-17
UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific... 92 3e-17
UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep: ... 92 4e-17
UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to ENSANGP000... 91 5e-17
UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep: ... 91 5e-17
UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble gu... 91 7e-17
UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:... 91 7e-17
UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1; Pl... 91 1e-16
UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7; ... 90 1e-16
UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate ... 90 2e-16
UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 89 2e-16
UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6; Mu... 89 3e-16
UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|R... 88 5e-16
UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate ... 88 7e-16
UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella ve... 88 7e-16
UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 87 9e-16
UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;... 87 9e-16
UniRef50_A2ECV6 Cluster: Adenylate and Guanylate cyclase catalyt... 87 9e-16
UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC 4.6... 87 1e-15
UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 87 1e-15
UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|R... 87 1e-15
UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble gu... 87 2e-15
UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl c... 87 2e-15
UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep: ... 86 2e-15
UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalyt... 86 2e-15
UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8; E... 86 2e-15
UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl c... 86 3e-15
UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalyt... 86 3e-15
UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2; St... 85 4e-15
UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalyt... 85 4e-15
UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|R... 85 5e-15
UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theile... 85 5e-15
UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella ve... 85 5e-15
UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 85 6e-15
UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3; D... 84 8e-15
UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to ENSANGP000... 84 1e-14
UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1; Eryth... 84 1e-14
UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 84 1e-14
UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep: ... 84 1e-14
UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila melanogaster|... 83 2e-14
UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalyt... 83 2e-14
UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 83 3e-14
UniRef50_Q24GP9 Cluster: Adenylate and Guanylate cyclase catalyt... 82 3e-14
UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalyt... 82 3e-14
UniRef50_A2GB93 Cluster: Adenylate and Guanylate cyclase catalyt... 82 4e-14
UniRef50_A2DWV8 Cluster: Adenylate and Guanylate cyclase catalyt... 82 4e-14
UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4; ... 82 4e-14
UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1; Al... 81 6e-14
UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3; Caenor... 81 6e-14
UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1; Ca... 81 6e-14
UniRef50_A2ES71 Cluster: Adenylate and Guanylate cyclase catalyt... 81 6e-14
UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 81 1e-13
UniRef50_A2DTD4 Cluster: Adenylate and Guanylate cyclase catalyt... 81 1e-13
UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic d... 80 1e-13
UniRef50_Q4TB76 Cluster: Chromosome undetermined SCAF7184, whole... 80 2e-13
UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella ve... 79 2e-13
UniRef50_A0P034 Cluster: Adenylate cyclase; n=1; Stappia aggrega... 79 3e-13
UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 79 3e-13
UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalyt... 79 3e-13
UniRef50_Q6DNF3 Cluster: Soluble guanylate cyclase gcy-37; n=2; ... 79 3e-13
UniRef50_UPI0000F1FEB6 Cluster: PREDICTED: similar to solble gua... 79 4e-13
UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 79 4e-13
UniRef50_A2DKP6 Cluster: Adenylate and Guanylate cyclase catalyt... 79 4e-13
UniRef50_A2DBX9 Cluster: Adenylate and Guanylate cyclase catalyt... 78 5e-13
UniRef50_A5NV94 Cluster: Response regulator receiver protein; n=... 78 7e-13
UniRef50_A2G2M4 Cluster: Adenylate and Guanylate cyclase catalyt... 78 7e-13
UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11... 77 1e-12
UniRef50_A2FPM7 Cluster: Adenylate and Guanylate cyclase catalyt... 77 1e-12
UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|R... 77 1e-12
UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalyt... 77 1e-12
UniRef50_A2FZG6 Cluster: Adenylate and Guanylate cyclase catalyt... 77 2e-12
UniRef50_A2FB45 Cluster: Adenylate and Guanylate cyclase catalyt... 76 2e-12
UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalyt... 76 2e-12
UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalyt... 75 4e-12
UniRef50_Q4RZ92 Cluster: Chromosome 1 SCAF14944, whole genome sh... 75 5e-12
UniRef50_A3YYJ3 Cluster: Putative uncharacterized protein; n=1; ... 75 7e-12
UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalyt... 75 7e-12
UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gamb... 73 2e-11
UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalyt... 73 2e-11
UniRef50_A0NC46 Cluster: ENSANGP00000018386; n=1; Anopheles gamb... 73 2e-11
UniRef50_UPI0000E490E0 Cluster: PREDICTED: similar to guanylate ... 73 3e-11
UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 73 3e-11
UniRef50_Q4BYX5 Cluster: Guanylate cyclase:Histidine kinase, HAM... 73 3e-11
UniRef50_A0LFQ5 Cluster: Adenylate/guanylate cyclase precursor; ... 73 3e-11
UniRef50_A0LQP8 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 72 4e-11
UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalyt... 72 4e-11
UniRef50_A6PCE2 Cluster: Putative adenylate/guanylate cyclase pr... 72 5e-11
UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalyt... 72 5e-11
UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalyt... 72 5e-11
UniRef50_UPI0000DB7371 Cluster: PREDICTED: similar to Guanylyl c... 71 6e-11
UniRef50_Q9GVB8 Cluster: Guanylyl cyclase enzyme; n=3; Plasmodiu... 71 6e-11
UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalyt... 71 8e-11
UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific... 71 8e-11
UniRef50_Q09BE7 Cluster: Adenylate cyclase 1; n=1; Stigmatella a... 71 1e-10
UniRef50_A7NLF3 Cluster: Adenylate/guanylate cyclase with GAF se... 70 1e-10
UniRef50_A0QDI3 Cluster: Adenylate and Guanylate cyclase catalyt... 70 1e-10
UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalyt... 70 1e-10
UniRef50_Q6MNW4 Cluster: Adenylate cyclase precursor; n=1; Bdell... 70 2e-10
UniRef50_A2D8T2 Cluster: Adenylate and Guanylate cyclase catalyt... 70 2e-10
UniRef50_Q0EZ20 Cluster: Adenylate/Guanylate Cyclase; n=1; Marip... 69 3e-10
UniRef50_Q17010 Cluster: Soluble guanylate cyclase; n=14; Cellia... 69 3e-10
UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalyt... 69 3e-10
UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalyt... 69 3e-10
UniRef50_Q1QA64 Cluster: Adenylate/guanylate cyclase; n=1; Psych... 69 4e-10
UniRef50_Q0LGQ8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 69 4e-10
UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalyt... 69 4e-10
UniRef50_A0MJN0 Cluster: Guanylate cyclase beta; n=11; Plasmodiu... 69 4e-10
UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 68 6e-10
UniRef50_Q08NP4 Cluster: Adenylate cyclase 1; n=2; Cystobacterin... 68 6e-10
UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalyt... 68 6e-10
UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalyt... 68 6e-10
UniRef50_P40137 Cluster: Adenylate cyclase 1; n=2; Stigmatella a... 68 6e-10
UniRef50_A0NLS4 Cluster: Adenylate cyclase 1; n=1; Stappia aggre... 68 8e-10
UniRef50_A0L8N6 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 67 1e-09
UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25... 67 1e-09
UniRef50_Q2LSB8 Cluster: Adenylate and guanylate cyclase catalyt... 66 2e-09
UniRef50_A7RY93 Cluster: Predicted protein; n=2; Nematostella ve... 66 2e-09
UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalyt... 66 2e-09
UniRef50_Q4T0C2 Cluster: Chromosome undetermined SCAF11234, whol... 66 2e-09
UniRef50_Q6FCE8 Cluster: Putative adenylate or guanylate cyclase... 66 3e-09
UniRef50_Q1DD79 Cluster: Adenylate/guanylate cyclase domain prot... 65 5e-09
UniRef50_A7BYP5 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 65 5e-09
UniRef50_A0LB38 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 64 7e-09
UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2; ... 64 9e-09
UniRef50_Q2LS04 Cluster: Adenylate cyclase; n=1; Syntrophus acid... 64 1e-08
UniRef50_Q9HZ23 Cluster: CyaB; n=13; Gammaproteobacteria|Rep: Cy... 63 2e-08
UniRef50_A4BIA0 Cluster: Adenylate/guanylate cyclase; n=1; Reine... 63 2e-08
UniRef50_A1WY91 Cluster: Putative adenylate/guanylate cyclase pr... 63 2e-08
UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalyt... 63 2e-08
UniRef50_Q98GL0 Cluster: Mlr3277 protein; n=5; Rhizobiales|Rep: ... 63 2e-08
UniRef50_Q2BGD8 Cluster: Adenylate cyclase; n=1; Neptuniibacter ... 63 2e-08
UniRef50_A7BVW4 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 63 2e-08
UniRef50_A2F3J3 Cluster: Adenylate and Guanylate cyclase catalyt... 62 3e-08
UniRef50_P72951 Cluster: Adenylate cyclase; n=2; Chroococcales|R... 62 4e-08
UniRef50_Q0VSG5 Cluster: Adenylate cyclase family proteine ident... 62 4e-08
UniRef50_UPI000065CD57 Cluster: Heat-stable enterotoxin receptor... 62 5e-08
UniRef50_Q98DR2 Cluster: Adenylate cyclase; n=1; Mesorhizobium l... 62 5e-08
UniRef50_Q92ZZ5 Cluster: Adenylate cyclase, putative; n=3; Alpha... 62 5e-08
UniRef50_Q1VN94 Cluster: Two-component hybrid sensor and regulat... 62 5e-08
UniRef50_A0Y7P2 Cluster: Adenylate/guanylate cyclase; n=1; marin... 62 5e-08
UniRef50_Q3SK56 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 61 7e-08
UniRef50_Q0YLX9 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 61 7e-08
UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalyt... 61 7e-08
UniRef50_Q7A2G7 Cluster: Adenylate cyclase; n=4; Nostocaceae|Rep... 61 9e-08
UniRef50_A0YII8 Cluster: Adenylate cyclase; n=2; Bacteria|Rep: A... 61 9e-08
UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalyt... 61 9e-08
UniRef50_Q8YVS0 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 60 1e-07
UniRef50_Q1NTA6 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 60 1e-07
UniRef50_Q2LQ30 Cluster: HD domain protein; n=1; Syntrophus acid... 60 2e-07
UniRef50_A4BGN9 Cluster: Adenylate cyclase, family 3; n=1; Reine... 60 2e-07
UniRef50_Q5ZVF0 Cluster: Adenylate cyclase PLUS two component hy... 60 2e-07
UniRef50_Q09E49 Cluster: Adenylate cyclase 2; n=2; Stigmatella a... 60 2e-07
UniRef50_A0XZ14 Cluster: Adenylate cyclase, family 3; n=1; Alter... 60 2e-07
UniRef50_Q21LJ4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 59 3e-07
UniRef50_Q0VR65 Cluster: Adenylate cyclase; n=1; Alcanivorax bor... 59 3e-07
UniRef50_A0Y8Z4 Cluster: Adenylate cyclase; n=1; marine gamma pr... 59 3e-07
UniRef50_Q3DXV1 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 59 4e-07
UniRef50_A0FNG2 Cluster: Adenylate/guanylate cyclase; n=1; Burkh... 59 4e-07
UniRef50_Q0LHB3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 58 5e-07
UniRef50_Q0EZU7 Cluster: Adenylate/Guanylate Cyclase; n=1; Marip... 58 5e-07
UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep: ... 58 5e-07
UniRef50_Q1N6Q8 Cluster: Probable adenylate cyclase; n=1; Oceano... 58 6e-07
UniRef50_Q10W13 Cluster: Adenylate/guanylate cyclase; n=2; Oscil... 58 6e-07
UniRef50_A7BYP4 Cluster: Guanylyl cyclase; n=1; Beggiatoa sp. PS... 58 6e-07
UniRef50_A6GEM5 Cluster: Adenylate cyclase; n=1; Plesiocystis pa... 58 6e-07
UniRef50_Q5CRV8 Cluster: Membrane associated adenyl cyclase with... 58 6e-07
UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 58 8e-07
UniRef50_Q89D21 Cluster: Bll7624 protein; n=7; Alphaproteobacter... 58 8e-07
UniRef50_Q10Z12 Cluster: Adenylate/guanylate cyclase; n=1; Trich... 58 8e-07
UniRef50_A6G1S4 Cluster: Putative adenylate cyclase; n=1; Plesio... 58 8e-07
UniRef50_A1T6C4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 58 8e-07
UniRef50_Q89K68 Cluster: Bll5043 protein; n=2; Bradyrhizobiaceae... 57 1e-06
UniRef50_Q08MU2 Cluster: Putative uncharacterized protein; n=2; ... 57 1e-06
UniRef50_A5V6C5 Cluster: Putative adenylate/guanylate cyclase; n... 57 1e-06
UniRef50_A3PVY7 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 57 1e-06
UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalyt... 57 1e-06
UniRef50_Q0EZJ3 Cluster: Adenylate cyclase; n=1; Mariprofundus f... 57 1e-06
UniRef50_A4ADE9 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 57 1e-06
UniRef50_A0YCM6 Cluster: Adenylate/Guanylate Cyclase; n=1; marin... 57 1e-06
UniRef50_A0WBT7 Cluster: Adenylate/guanylate cyclase precursor; ... 57 1e-06
UniRef50_Q2BPD5 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 56 2e-06
UniRef50_Q1YP13 Cluster: Probable adenylate cyclase; n=1; gamma ... 56 2e-06
UniRef50_A0PTR6 Cluster: Adenylylate/guanylate cyclase; n=1; Myc... 56 2e-06
UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6; Di... 56 2e-06
UniRef50_UPI000038C573 Cluster: COG2114: Adenylate cyclase, fami... 56 3e-06
UniRef50_Q1M6K1 Cluster: Putative transmembrane adenylate cyclas... 56 3e-06
UniRef50_A6LJV0 Cluster: Putative adenylate/guanylate cyclase; n... 56 3e-06
UniRef50_A0YWU6 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 56 3e-06
UniRef50_A0NUX8 Cluster: Adenylate cyclase 1 protein; n=1; Stapp... 56 3e-06
UniRef50_A0NQ18 Cluster: Putative uncharacterized protein; n=1; ... 56 3e-06
UniRef50_A0LM28 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 56 3e-06
UniRef50_A0LDY9 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 56 3e-06
UniRef50_Q5CUX5 Cluster: P-type ATpase fused to two adenyl cycla... 56 3e-06
UniRef50_Q8DGN6 Cluster: Adenylate cyclase; n=1; Synechococcus e... 55 4e-06
UniRef50_Q7WX64 Cluster: Putative sensor kinase; n=1; Ralstonia ... 55 4e-06
UniRef50_A6GS32 Cluster: Adenylate/guanylate cyclase; n=1; Limno... 55 4e-06
UniRef50_Q7UN49 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 55 6e-06
UniRef50_A3EW56 Cluster: Adenylate cyclase; n=1; Leptospirillum ... 55 6e-06
UniRef50_Q89SR2 Cluster: Bll2338 protein; n=4; Bradyrhizobiaceae... 54 1e-05
UniRef50_Q2K752 Cluster: Probable adenylate cyclase protein; n=2... 54 1e-05
UniRef50_Q123E0 Cluster: Adenylate/guanylate cyclase; n=1; Polar... 54 1e-05
UniRef50_A5P1B9 Cluster: CHASE3 domain protein precursor; n=1; M... 54 1e-05
UniRef50_A4GJB3 Cluster: Adenylate/guanylate cyclase; n=1; uncul... 54 1e-05
UniRef50_A3WDP1 Cluster: Adenylate/Guanylate Cyclase; n=1; Eryth... 54 1e-05
UniRef50_A4XM29 Cluster: Putative adenylate/guanylate cyclase; n... 54 1e-05
UniRef50_A4MIN5 Cluster: Adenylate/guanylate cyclase precursor; ... 54 1e-05
UniRef50_A7BVP0 Cluster: Adenylate/Guanylate cyclase; n=1; Beggi... 53 2e-05
UniRef50_UPI0000383FA3 Cluster: COG4252: Predicted transmembrane... 53 2e-05
UniRef50_Q2IUL6 Cluster: Adenylate/guanylate cyclase precursor; ... 53 2e-05
UniRef50_Q0LIY8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 53 2e-05
UniRef50_A6GG85 Cluster: Putative adenylate cyclase; n=1; Plesio... 53 2e-05
UniRef50_A4Z3F2 Cluster: Putative Adenylate cyclase; n=1; Bradyr... 53 2e-05
UniRef50_A2F7J9 Cluster: Adenylate and Guanylate cyclase catalyt... 53 2e-05
UniRef50_Q8EXW3 Cluster: Adenylate cyclase; n=2; Leptospira inte... 52 3e-05
UniRef50_Q5ZVW6 Cluster: Adenylate cyclase 1 protein; n=4; Legio... 52 3e-05
UniRef50_Q1YML1 Cluster: Putative adenylate/guanylate cyclase wi... 52 3e-05
UniRef50_Q1IS04 Cluster: Adenylate/guanylate cyclase; n=1; Acido... 52 3e-05
UniRef50_A7BPS8 Cluster: Two-component hybrid sensor and regulat... 52 3e-05
UniRef50_P19485 Cluster: Adenylate cyclase 1; n=2; Sinorhizobium... 52 3e-05
UniRef50_Q7A2D9 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 52 4e-05
UniRef50_Q1GW96 Cluster: Adenylate/guanylate cyclase precursor; ... 52 4e-05
UniRef50_A0LFQ6 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 52 4e-05
UniRef50_UPI000065F95C Cluster: Homolog of Oryzias latipes "Solu... 52 5e-05
UniRef50_Q7A2H3 Cluster: Adenylate cyclase; n=5; Nostocaceae|Rep... 52 5e-05
UniRef50_Q8F152 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 51 7e-05
UniRef50_Q89RB9 Cluster: Bll2853 protein; n=1; Bradyrhizobium ja... 51 7e-05
UniRef50_Q89FJ3 Cluster: Bll6707 protein; n=1; Bradyrhizobium ja... 51 7e-05
UniRef50_Q73P67 Cluster: Adenylate/guanylate cyclase catalytic d... 51 7e-05
UniRef50_Q2K6R9 Cluster: Adenylate cyclase protein; n=4; Rhizobi... 51 7e-05
UniRef50_Q3E5U5 Cluster: PAS:Adenylyl cyclase class-3/4/guanylyl... 51 7e-05
UniRef50_Q1N335 Cluster: Adenylate cyclase, family 3; n=1; Ocean... 51 7e-05
UniRef50_Q8F210 Cluster: Adenylate cyclase; n=2; Leptospira inte... 51 9e-05
UniRef50_Q89II7 Cluster: Bll5647 protein; n=5; Bradyrhizobiaceae... 51 9e-05
UniRef50_Q1VLI3 Cluster: Adenylate cyclase; n=1; Psychroflexus t... 51 9e-05
UniRef50_Q1IQP7 Cluster: Adenylate/guanylate cyclase; n=1; Acido... 51 9e-05
UniRef50_Q111B1 Cluster: Adenylate/guanylate cyclase; n=2; Bacte... 51 9e-05
UniRef50_A7NNT7 Cluster: Adenylate/guanylate cyclase with GAF an... 51 9e-05
UniRef50_A1WTT4 Cluster: Putative Chase2 sensor protein precurso... 51 9e-05
UniRef50_Q1GZE1 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 50 1e-04
UniRef50_Q0LK40 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 50 1e-04
UniRef50_A2G3F5 Cluster: Adenylate and Guanylate cyclase catalyt... 50 1e-04
UniRef50_Q5ZUQ4 Cluster: Adenylate/guanylate cyclase transmembra... 50 2e-04
UniRef50_Q3DYQ5 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 50 2e-04
UniRef50_Q164Z4 Cluster: Conserved domain protein; n=1; Roseobac... 50 2e-04
UniRef50_A3WI89 Cluster: Adenylate/guanylate cyclase catalytic d... 50 2e-04
UniRef50_Q15YL4 Cluster: Adenylate/guanylate cyclase precursor; ... 50 2e-04
UniRef50_O32392 Cluster: Adenylate cyclase; n=2; Bacteria|Rep: A... 50 2e-04
UniRef50_Q92ZC3 Cluster: Probable adenylate cyclase; n=3; Sinorh... 49 3e-04
UniRef50_Q8F2W9 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 49 3e-04
UniRef50_Q89KX9 Cluster: Bll4769 protein; n=1; Bradyrhizobium ja... 49 3e-04
UniRef50_Q2JH00 Cluster: Adenylate/guanylate cyclase; n=4; Frank... 49 3e-04
UniRef50_A4BFI0 Cluster: Adenylate cyclase, family 3; n=1; Reine... 49 3e-04
UniRef50_Q3A5C7 Cluster: Predicted ATPase, putative adenylate/gu... 49 4e-04
UniRef50_Q1PXG2 Cluster: Putative uncharacterized protein; n=1; ... 49 4e-04
UniRef50_A4Z0R3 Cluster: Putative Adenylate cyclase; n=1; Bradyr... 49 4e-04
UniRef50_Q92XH7 Cluster: Putative adenylate cyclase; n=2; Sinorh... 48 5e-04
UniRef50_Q89IJ7 Cluster: Blr5637 protein; n=4; Rhizobiales|Rep: ... 48 5e-04
UniRef50_Q7UPH0 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 48 5e-04
UniRef50_Q3DXI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 48 5e-04
UniRef50_Q1MJZ0 Cluster: Putative adenylate/guanylate cyclase; n... 48 5e-04
UniRef50_Q118H4 Cluster: Adenylate/guanylate cyclase; n=5; Bacte... 48 5e-04
UniRef50_A4U258 Cluster: Guanylate cyclase:CHASE2; n=1; Magnetos... 48 5e-04
UniRef50_Q0F3A7 Cluster: Adenylate/guanylate cyclase; n=1; Marip... 48 7e-04
UniRef50_Q04UM6 Cluster: Adenylate cyclase related protein; n=4;... 48 7e-04
UniRef50_A6UL86 Cluster: Sterile alpha motif SAM protein; n=1; S... 48 7e-04
UniRef50_A5V2T6 Cluster: Putative adenylate/guanylate cyclase pr... 48 7e-04
UniRef50_A1K340 Cluster: Putative adenylate/guanylate cyclase; n... 48 7e-04
UniRef50_A0L8S3 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 48 7e-04
UniRef50_Q8F2D7 Cluster: Adenylate cyclase; n=2; Leptospira inte... 48 9e-04
UniRef50_Q113T7 Cluster: Adenylate/guanylate cyclase; n=1; Trich... 48 9e-04
UniRef50_Q08WA0 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 48 9e-04
UniRef50_A7BU84 Cluster: Methyl-accepting chemotaxis sensory tra... 48 9e-04
UniRef50_A0YWK8 Cluster: Putative adenylate cyclase; n=1; Lyngby... 48 9e-04
UniRef50_A0PW43 Cluster: Conserved hypothetical transmembrane pr... 48 9e-04
UniRef50_A0LAQ0 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 48 9e-04
UniRef50_UPI0000E48651 Cluster: PREDICTED: similar to membrane g... 47 0.001
UniRef50_Q8EXU0 Cluster: Adenylate cyclase; n=2; Leptospira inte... 47 0.001
UniRef50_Q6MJX6 Cluster: Adenylate cyclase; n=1; Bdellovibrio ba... 47 0.001
UniRef50_Q0B020 Cluster: Transmembrane sensor domain-like protei... 47 0.001
UniRef50_A7BXW8 Cluster: Adenylate cyclase; n=3; Beggiatoa|Rep: ... 47 0.001
UniRef50_A1IE43 Cluster: Adenylate cyclase precursor; n=1; Candi... 47 0.001
UniRef50_A0YVQ1 Cluster: Two-component hybrid sensor and regulat... 47 0.001
UniRef50_A0L6N6 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 47 0.001
UniRef50_A2DJR4 Cluster: Adenylate and Guanylate cyclase catalyt... 47 0.001
UniRef50_Q92YL0 Cluster: Putative adenylate cyclase; n=1; Sinorh... 47 0.002
UniRef50_Q8UCB8 Cluster: Adenylate cyclase; n=1; Agrobacterium t... 47 0.002
UniRef50_A7BZE8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 47 0.002
UniRef50_Q20XY3 Cluster: Adenylate/guanylate cyclase; n=1; Rhodo... 46 0.002
UniRef50_A3YU70 Cluster: Guanylyl cyclase; n=1; Synechococcus sp... 46 0.002
>UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12;
Coelomata|Rep: CG32158-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1662
Score = 533 bits (1314), Expect = e-150
Identities = 263/409 (64%), Positives = 305/409 (74%), Gaps = 8/409 (1%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTV 186
++ +IV+ + +V+A LL LS+PAMNEI+L+ +SYV+L FL IE + +
Sbjct: 335 LVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFN 394
Query: 187 STGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLL----DNSSDM----QLYCT 238
+ C + Y+TY LP+RL EA IGG+ L+ V++ L L D + +M +L CT
Sbjct: 395 GSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCT 454
Query: 239 IATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAM 298
+ L+ N G+ TH P+E AQR+AF+ETR C+EA SVLPRHVAM
Sbjct: 455 LVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAM 514
Query: 299 EMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFD 358
EMK DIA QPR QFHKIYIQR+ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFD
Sbjct: 515 EMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFD 574
Query: 359 RLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMR 418
RLAAEHHCLRIKLLGDCYYCVSGLPE R DHA C VEMGLDMIDAIALVREVMAVNVNMR
Sbjct: 575 RLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMR 634
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
VGIHTGRVHC VLGL KWQFDVWSNDVTLAN+MESGG+ GRVHITKETL CL DY+VE
Sbjct: 635 VGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEV 694
Query: 479 GHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNVSKEMRVM 527
G G RN+YLKDH IETYLIVP D R KK ++ VNGN+SKE+R+M
Sbjct: 695 GKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMM 743
Score = 84.6 bits (200), Expect = 6e-15
Identities = 61/188 (32%), Positives = 90/188 (47%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + R + +Y ++ ++V ILFA I F+ L E
Sbjct: 1073 NILPVHVAEHFLS------REKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVE 1126
Query: 346 LVRLLNELFARFDRLAAEHH--CL-RIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD L +E C+ +IK G Y SGL D H +
Sbjct: 1127 CLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYA 1186
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
L + D I V N MR+GI+ G V V+G K Q+D+W N V +A+ M+S G+
Sbjct: 1187 LQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLV 1246
Query: 458 GRVHITKE 465
+ +T+E
Sbjct: 1247 DHIQVTQE 1254
Score = 41.5 bits (93), Expect = 0.058
Identities = 17/20 (85%), Positives = 19/20 (95%)
Query: 22 KVEMLYQRYFLRMNQTNMTH 41
+VEMLYQRYFLRMNQ+N TH
Sbjct: 63 QVEMLYQRYFLRMNQSNTTH 82
>UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG32158-PB, isoform B - Tribolium castaneum
Length = 1333
Score = 522 bits (1288), Expect = e-147
Identities = 254/402 (63%), Positives = 298/402 (74%), Gaps = 2/402 (0%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTV 186
++ + G ++ LLA LS+PAMNE+YL+ ISY +LV FL +E + S +
Sbjct: 342 LVLICTSGCCIAIYGVLLAVLSKPAMNEVYLIIISYFILVTFLTLEICISFFSETERPLL 401
Query: 187 STGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATLIAC- 245
TY+TYA +P+RL +A + G LA + + + + + ++ C
Sbjct: 402 GPTFSLATTYLTYALMPIRLKDALLAGTVLALTQVILLVYVGQLYAIADITSCFVILLCG 461
Query: 246 NAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIA 305
N AG+ TH PRE+AQR+AFLETR C+EA SVLPRHVAMEMKADIA
Sbjct: 462 NVAGVCTHYPREVAQRKAFLETRQCIEARLKIQRENQQQERLLLSVLPRHVAMEMKADIA 521
Query: 306 SQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHH 365
QP+ QFHKIYIQR+ENVSILFADICGFT+LSDQCTAEELVR+LNELFARFDRLAAEHH
Sbjct: 522 GQPKEAQFHKIYIQRHENVSILFADICGFTTLSDQCTAEELVRILNELFARFDRLAAEHH 581
Query: 366 CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR 425
CLRIKLLGDCYYCVSGLPEAR DHA C VEMGLDMIDAIALVREVM+VNVNMRVGIHTGR
Sbjct: 582 CLRIKLLGDCYYCVSGLPEARPDHAHCTVEMGLDMIDAIALVREVMSVNVNMRVGIHTGR 641
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRN 485
VHC VLGLRKWQFDVWSNDVTLAN+MESGG+ GRVHITKETL CLG+DY VEPG+GG RN
Sbjct: 642 VHCGVLGLRKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLGNDYVVEPGNGGDRN 701
Query: 486 AYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNVSKEMRVM 527
+YLKDHNI+TYLIV + P + ++NGN+SKEMRVM
Sbjct: 702 SYLKDHNIDTYLIVAPSCFQ-GSTPYQNHSMNGNISKEMRVM 742
Score = 89.4 bits (212), Expect = 2e-16
Identities = 72/254 (28%), Positives = 114/254 (44%), Gaps = 18/254 (7%)
Query: 224 HLLLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXX 283
H + + ++ Q Y I L+ A +L Q E R F+ E
Sbjct: 1010 HAMHNETTLTQQYVNIVILVGFVIALILHGQQTEATYRLDFVWKLQATEEKEDMEHLEAY 1069
Query: 284 XXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSD 339
++LP HVA + S +++ +Y ++ + V I+FA I F+ L
Sbjct: 1070 NRKLLANILPVHVAEHF---LNSDKNNDE---LYHEQCDFVCIMFASIPNFSEFYVELEG 1123
Query: 340 QCTAEELVRLLNELFARFDRLAAEH---HCLRIKLLGDCYYCVSGLPEARDD-----HAK 391
E +RLLNE+ A FD L +E + +IK G Y SGL + D H
Sbjct: 1124 NNEGVECLRLLNEIIADFDELLSEDQFKYIEKIKSTGATYMAASGLTQNTCDMQGYRHVT 1183
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ L + + +A V E + +R+GI+ G V V+G RK Q+D+W N V +A+ M
Sbjct: 1184 AMADYALRIQEQLAEVNEHSFNHFRIRIGINVGPVVAGVIGARKPQYDIWGNAVNVASRM 1243
Query: 452 ESGGVAGRVHITKE 465
+S GV ++ +TKE
Sbjct: 1244 DSTGVLDKIQVTKE 1257
Score = 39.9 bits (89), Expect = 0.18
Identities = 16/20 (80%), Positives = 20/20 (100%)
Query: 22 KVEMLYQRYFLRMNQTNMTH 41
+VEMLYQRYFL+MNQ+NMT+
Sbjct: 281 QVEMLYQRYFLKMNQSNMTN 300
>UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41;
Deuterostomia|Rep: Adenylate cyclase type 5 - Homo
sapiens (Human)
Length = 1261
Score = 414 bits (1020), Expect = e-114
Identities = 208/382 (54%), Positives = 260/382 (68%), Gaps = 5/382 (1%)
Query: 132 VLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGAC 191
VL + V + +R A ++ ++ Y ++ L ++ RS +
Sbjct: 273 VLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWT 332
Query: 192 SLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM----QLYCTIATLIACNA 247
F Y Y LPVR+ A + G+ L+A+++ A L N+ D QL + N
Sbjct: 333 VFFIYTIYTLLPVRMRAAVLSGVLLSALHL-AIALRTNAQDQFLLKQLVSNVLIFSCTNI 391
Query: 248 AGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQ 307
G+ TH P E++QR+AF ETR+C++A SVLPRHVAMEMKADI ++
Sbjct: 392 VGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK 451
Query: 308 PRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 367
FHKIYIQ+++NVSILFADI GFTSL+ QCTA+ELV LNELFARFD+LAAE+HCL
Sbjct: 452 QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511
Query: 368 RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVH 427
RIK+LGDCYYCVSGLPEAR DHA CCVEMG+DMI+AI+LVREV VNVNMRVGIH+GRVH
Sbjct: 512 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVH 571
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAY 487
C VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HITK TL L DY+VEPG GG RNAY
Sbjct: 572 CGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAY 631
Query: 488 LKDHNIETYLIVPDDTSRVDKK 509
LK+H+IET+LI+ R ++K
Sbjct: 632 LKEHSIETFLILRCTQKRKEEK 653
Score = 95.1 bits (226), Expect = 4e-18
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 20/277 (7%)
Query: 215 ALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAAGMLTH-QPRELAQRRAFLETRDCVEA 273
A+ N G ++++ + L +I+ + H Q E R FL E
Sbjct: 966 AIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE 1025
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICG 333
++LP+ VA +A + R+++ +Y Q E V+++FA I
Sbjct: 1026 KEEMEELQAYNRRLLHNILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASIAN 1079
Query: 334 FTSLSDQCTAE----ELVRLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGLPEAR 386
F+ + A E +RLLNE+ A FD + +E +IK +G Y SGL ++
Sbjct: 1080 FSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDST 1139
Query: 387 DD-----HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVW 441
D H K + + ++D + + E N M++G++ G V V+G RK Q+D+W
Sbjct: 1140 YDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW 1199
Query: 442 SNDVTLANYMESGGVAGRVHITKETLCCL-GDDYKVE 477
N V +A+ M+S GV R+ +T + L + Y++E
Sbjct: 1200 GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLE 1236
>UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1085
Score = 385 bits (948), Expect = e-105
Identities = 200/414 (48%), Positives = 257/414 (62%), Gaps = 5/414 (1%)
Query: 117 IYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFA 176
I++ + + +VLG+ L F L L R ++ + L IS++ L L + +
Sbjct: 118 IFFYTNGLTSPVRGVVLGIIVLTFVVLEVLLYRITLDFLTLQIISFLSLFLLLAVVCTIT 177
Query: 177 GTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAA--VNIGAHLLLDNSSDM- 233
+ ++ F Y+ Y +P+ + A + G+ L V++ ++ + S
Sbjct: 178 LDTEPHDVSDGLWVTVFFVYMIYTGIPISMSAALVSGVLLPVFQVSLASNFNVSQSYVRD 237
Query: 234 QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLP 293
Q+ + I N G+ H P E QR AFLETR+C+ SVLP
Sbjct: 238 QVVANVFIYICVNVIGVYFHYPMEAQQREAFLETRNCISVRLAMQKENQKQERLLLSVLP 297
Query: 294 RHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNEL 353
RHVAMEMKADIA + FHKIYIQR++NVSILFADICGFT+LS CTA+ELV+LLNEL
Sbjct: 298 RHVAMEMKADIAGNKKEAMFHKIYIQRHDNVSILFADICGFTALSSTCTAQELVQLLNEL 357
Query: 354 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAV 413
+ARFD LA E+HCLRIKLLGDCYYCVSG+P+ R DHA C VEMGLDM++AIALVR++
Sbjct: 358 YARFDSLATENHCLRIKLLGDCYYCVSGMPDPRRDHAHCAVEMGLDMVEAIALVRDLTGT 417
Query: 414 NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
NVNMRVGIH+GRVHC VLGL KWQFDVWSNDVTLAN+MESGG+ G VHI+ T L D
Sbjct: 418 NVNMRVGIHSGRVHCGVLGLYKWQFDVWSNDVTLANHMESGGLPGHVHISSATKDYLNGD 477
Query: 474 YKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNVSKEMRVM 527
Y +EPG G R++Y+K IETYLI DT R P S +G S M++M
Sbjct: 478 YDLEPGDGASRDSYIKQCGIETYLI-KVDTRRHKSVPFESRREHG-TSGAMKLM 529
Score = 79.8 bits (188), Expect = 2e-13
Identities = 51/176 (28%), Positives = 82/176 (46%), Gaps = 12/176 (6%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELFARFDRLAAEHHCL--- 367
K+Y + NV ++FA I F+ + A E +RLLNE+ A FD L
Sbjct: 877 KLYYEDINNVGVMFASIVNFSEFYMELEANNEGVECLRLLNEIIADFDTLLTHKRFFAVE 936
Query: 368 RIKLLGDCYYCVSGLPEARD----DHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
+IK +G Y C SGL + H + + + + + E N MR+G++
Sbjct: 937 KIKTVGQTYMCASGLTSRTNFLDMTHILALADYTFALKNQLEYINENSFNNFVMRIGLNI 996
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLG-DDYKVEP 478
G V V+G +K +D+W N V +A+ M+S G ++ +T E L + Y + P
Sbjct: 997 GPVVAGVIGAKKPHYDIWGNTVNVASRMDSTGEPNKIQVTAEMYRILSKNKYSLSP 1052
>UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate
cyclase; n=5; Coelomata|Rep:
Ca(2+)/calmodulin-responsive adenylate cyclase -
Drosophila melanogaster (Fruit fly)
Length = 2248
Score = 370 bits (911), Expect = e-101
Identities = 199/388 (51%), Positives = 256/388 (65%), Gaps = 18/388 (4%)
Query: 126 HIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLV---AFLLIEFSFAGT--SV 180
+I N IV GL A+V LL C + + +L T+ Y +L+ + ++ G+ V
Sbjct: 68 NIFNAIVCGLFAVVLV-LLQC---SVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPV 123
Query: 181 LRSLTVSTGACSLF--TYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM----- 233
++ G + ++ YA +P+++ EA G+AL +V+I + + +
Sbjct: 124 DTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEY 183
Query: 234 -QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVL 292
QL I I N AG++ + E AQRR FL+TR+C+ + SVL
Sbjct: 184 NQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVL 243
Query: 293 PRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNE 352
P+HVAM+MK DI S P QFH+IYIQ++ENVSILFADI GFT LS QC+A+ELVRLLNE
Sbjct: 244 PQHVAMQMKNDILS-PVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNE 302
Query: 353 LFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMA 412
LF RFD+LA ++HCLRIK+LGDCYYCVSGLPE R DHAKC VEMGLDMIDAIA V E
Sbjct: 303 LFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATD 362
Query: 413 VNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
V +NMRVGIHTGRV C VLGLRKWQFDVWSNDVTLAN+MESGG GRVH+T+ TL L
Sbjct: 363 VILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSG 422
Query: 473 DYKVEPGHGGYRNAYLKDHNIETYLIVP 500
+Y+VE GHG R++YL+DH ++T+ IVP
Sbjct: 423 EYEVEAGHGDERSSYLRDHGVDTFFIVP 450
Score = 79.4 bits (187), Expect = 2e-13
Identities = 61/195 (31%), Positives = 92/195 (47%), Gaps = 22/195 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGF----TSLSDQCTAEE 345
++LP HVA + +Q R+ ++Y Q Y V ++FA + F T + E
Sbjct: 933 NLLPAHVAAHF---LDAQFRNNM--ELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLE 987
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL----------PEARDDHAKC 392
+RLLNE+ A FD L E +IK +G Y V GL P + H
Sbjct: 988 CLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTA 1047
Query: 393 CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
+E M ++ + N +RVGI+ G V V+G RK Q+D+W N V +A+ M+
Sbjct: 1048 LIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMD 1107
Query: 453 SGGVAGRVHITKETL 467
S GV G +T+E +
Sbjct: 1108 STGVPGYSQVTQEVV 1122
>UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:
ENSANGP00000027378 - Anopheles gambiae str. PEST
Length = 2040
Score = 367 bits (902), Expect = e-100
Identities = 180/311 (57%), Positives = 227/311 (72%), Gaps = 7/311 (2%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNIGA---HLLLDNSSDM---QLYCTIATLIACNAAG 249
+++YA +P+++ EA + GL L ++++G ++ N + QL + + N AG
Sbjct: 141 FLSYAMMPLQIWEAALFGLILPSIHVGLTGYNIYTGNFQYLAYQQLAANMVIFVGVNVAG 200
Query: 250 MLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPR 309
+ + E AQRRAFL+TR+C+ A SVLP+HVAMEMK DI S P
Sbjct: 201 FVVNVMMERAQRRAFLDTRNCIAARLEMEDENEKLERLLLSVLPQHVAMEMKNDILS-PV 259
Query: 310 HEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRI 369
QFHKIYIQ++ENVSILFADI GFT L+ QC+A+ELVRLLNELF RFD+LA ++HCLRI
Sbjct: 260 EGQFHKIYIQKHENVSILFADIVGFTVLASQCSAQELVRLLNELFGRFDQLAHDNHCLRI 319
Query: 370 KLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCV 429
K+LGDCYYCVSG+P+ R DHA+C VEMGLDMIDAIA V E V +NMRVGIH+GRV C
Sbjct: 320 KILGDCYYCVSGIPDPRADHARCAVEMGLDMIDAIASVVEQTDVILNMRVGIHSGRVLCG 379
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLK 489
VLGLRKWQFDVWSNDVTLAN+MESGG GRVH+T+ TL LG +Y+VE GHG R++YL+
Sbjct: 380 VLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDALGGEYEVEAGHGDTRDSYLR 439
Query: 490 DHNIETYLIVP 500
D+ I+TY IVP
Sbjct: 440 DNEIDTYFIVP 450
Score = 80.6 bits (190), Expect = 1e-13
Identities = 59/195 (30%), Positives = 95/195 (48%), Gaps = 21/195 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGF----TSLSDQCTAEE 345
++LP HVA + ++ + +H Q Y V ++FA + F T L E
Sbjct: 925 NLLPSHVAAHFLDNQFARSNMDLYH----QSYSKVGVIFASVPNFHEFYTELDGSNQGVE 980
Query: 346 LVRLLNELFARFDRLAAEH--HCL-RIKLLGDCYYCVSGL-PEAR--DDHAKCCVEMGLD 399
+RLLNE+ A FD L E H + +IK +G Y GL PE + +
Sbjct: 981 CLRLLNEIIADFDELLCEERFHAIDKIKTVGSTYMAAVGLIPEHKMLPSEPGSMRRLMTA 1040
Query: 400 MIDAIALVREVMA-VNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
++D + +R + +N N +RVG++ G V V+G RK Q+D+W N V +A+ M+
Sbjct: 1041 LVDFVKAMRVTLKNINENSYNNFMLRVGVNVGPVVAGVIGARKPQYDIWGNTVNVASRMD 1100
Query: 453 SGGVAGRVHITKETL 467
S G+ G +T+E +
Sbjct: 1101 STGIPGYTQVTQEVV 1115
>UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1052
Score = 363 bits (892), Expect = 9e-99
Identities = 175/306 (57%), Positives = 219/306 (71%), Gaps = 4/306 (1%)
Query: 194 FTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATL---IACNAAGM 250
F Y+TY LPVR+ A GG L A+++ + ++ ++ + L I N G+
Sbjct: 210 FIYMTYTMLPVRMRIAVFGGCLLLALHLISSACVNRNNPNLARLLVGNLLLFICANITGV 269
Query: 251 LTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQ-PR 309
TH P E++QR+AFLETR C+EA SVLPR+VAMEMK DI S +
Sbjct: 270 FTHYPTEISQRQAFLETRRCIEARLTIQKENQNQERLLLSVLPRYVAMEMKDDIESGISQ 329
Query: 310 HEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRI 369
+ QFHKIYIQR+ENVSILFADI GFT LS QCTA+ L++ LNEL+ARFD+LA E+HCLRI
Sbjct: 330 NSQFHKIYIQRHENVSILFADIEGFTVLSSQCTAQSLIKTLNELYARFDQLAVENHCLRI 389
Query: 370 KLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCV 429
K+LGDCYYCVSGLP+ R DHA C+EMGL MIDAI+ VR+ VN+NMRVG+H G+VH
Sbjct: 390 KILGDCYYCVSGLPDPRPDHAHSCIEMGLAMIDAISFVRDATQVNLNMRVGVHMGKVHSG 449
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLK 489
VLGL KWQ+DVWS+DVT+AN+MESGG+ GRVHITKE L CL DY+VE GHG R++YLK
Sbjct: 450 VLGLVKWQYDVWSDDVTIANHMESGGLPGRVHITKEVLDCLNGDYEVEEGHGQERDSYLK 509
Query: 490 DHNIET 495
I++
Sbjct: 510 QLGIDS 515
Score = 85.0 bits (201), Expect = 5e-15
Identities = 70/249 (28%), Positives = 120/249 (48%), Gaps = 26/249 (10%)
Query: 231 SDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXS 290
SD+ + + ++A A G L Q R FL E +
Sbjct: 771 SDLSILIVVIFILALTAHGYLHEQ----ISRLDFLWKLQATEEKKEMEQLREYNKKLLYN 826
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----EL 346
+LP HVA A+ ++E +Y Q + V+++F++IC F+ + A E
Sbjct: 827 ILPVHVAQHFLGHKAN--KNED---LYYQSCDKVAVMFSNICNFSDFYTELDANGEGVEC 881
Query: 347 VRLLNELFARFDRLAAE--HHCL-RIKLLGDCYYCVSGL-PEARDDHAKCCVEMGLDMID 402
+RLLNE+ A FD L +E C+ +IK +G+ Y SG+ PE+++ A + M D
Sbjct: 882 LRLLNEILADFDELLSEPQFQCIEKIKTIGETYMAASGIKPESQEKLAT--LNHICTMAD 939
Query: 403 -AIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGG 455
A+A+ R++ +N++ M++G++ G V V+G K Q+D+W + V +A+ M S G
Sbjct: 940 FAMAMKRKLEDINLHSFNNFAMKIGLNFGPVVAGVIGAHKPQYDIWGDTVNVASRMYSTG 999
Query: 456 VAGRVHITK 464
+ +TK
Sbjct: 1000 KDNHIQVTK 1008
>UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=2;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 953
Score = 357 bits (877), Expect = 6e-97
Identities = 175/312 (56%), Positives = 216/312 (69%), Gaps = 5/312 (1%)
Query: 193 LFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIACNAA 248
L T+V YA LPVR A + G ++ +I + +L+ T+ ++ N +
Sbjct: 16 LVTFVAYALLPVRTLLAIVFGFMVSVSHIIVTATSISPKKKRLWRTLVVNAILFVSVNLS 75
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQP 308
G+ E AQR+AFL+ R+C+E S+LPR+VAMEMK D P
Sbjct: 76 GVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPP 135
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
FHKIYIQR++NVSILFADI GFTSL+ QCTA+ELV+LLNELF +FD LA E+HC R
Sbjct: 136 ERI-FHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRR 194
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 428
IK+LGDCYYCVSGL + + DHA CCVEMGLDMID I V E V++NMRVG+HTGRV C
Sbjct: 195 IKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLC 254
Query: 429 VVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYL 488
VLGLRKWQ+DVWSNDVTLAN ME+GG+ G+VHITK TL CL DY+VEPG+G RN++L
Sbjct: 255 GVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFL 314
Query: 489 KDHNIETYLIVP 500
K HNIET+ IVP
Sbjct: 315 KKHNIETFFIVP 326
Score = 83.4 bits (197), Expect = 1e-14
Identities = 60/192 (31%), Positives = 91/192 (47%), Gaps = 23/192 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 731 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVE 784
Query: 346 LVRLLNELFARFDRLAAEHHCLR----IKLLGDCYYCVSGLPEARDDHAKCCV------- 394
+RLLNE+ A FD L E C + IK +G Y GL AK +
Sbjct: 785 CLRLLNEIIADFDELM-EKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTL 843
Query: 395 -EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMES 453
+ ++M D + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S
Sbjct: 844 ADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDS 903
Query: 454 GGVAGRVHITKE 465
GV G++ +T++
Sbjct: 904 TGVQGKIQVTED 915
>UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=27; Euteleostomi|Rep: Adenylate
cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I)
(ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1119
Score = 354 bits (871), Expect = 3e-96
Identities = 186/382 (48%), Positives = 238/382 (62%), Gaps = 13/382 (3%)
Query: 137 ALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRS------LTVSTGA 190
AL+ + L P + ++ L + + + A L F+ G + + T G
Sbjct: 104 ALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGV 163
Query: 191 CSLF--TYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIA 244
L T+V+YA LPVR A GL +AA ++ L + +L+ T+ +
Sbjct: 164 WQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVG 223
Query: 245 CNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI 304
N G+ E +QR+AFL+ R C+E S+LPR+VAMEMK D
Sbjct: 224 VNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF 283
Query: 305 ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 364
P FHKIYIQR++NVSILFADI GFT L+ QCTA+ELV+LLNELF +FD LA E+
Sbjct: 284 LKPPERI-FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATEN 342
Query: 365 HCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 424
HC RIK+LGDCYYCVSGL + + DHA CCVEMGLDMID I V E V++NMRVG+HTG
Sbjct: 343 HCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTG 402
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYR 484
RV C VLGLRKWQ+DVWSNDVTLAN ME+ G+ G+VHITK TL CL DY+VEPG+G R
Sbjct: 403 RVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHER 462
Query: 485 NAYLKDHNIETYLIVPDDTSRV 506
N++LK HNIET+ IVP ++
Sbjct: 463 NSFLKTHNIETFFIVPSHRRKI 484
Score = 86.2 bits (204), Expect = 2e-15
Identities = 59/191 (30%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 839 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVE 892
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP--------EARDDHAKCCV 394
+RLLNE+ A FD L + +IK +G Y GL ++ H
Sbjct: 893 CLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLA 952
Query: 395 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESG 454
+ ++M D + + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S
Sbjct: 953 DFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDST 1012
Query: 455 GVAGRVHITKE 465
GV GR+ +T+E
Sbjct: 1013 GVQGRIQVTEE 1023
>UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep:
Adenylate cyclase - Aplysia californica (California sea
hare)
Length = 1339
Score = 343 bits (844), Expect = 6e-93
Identities = 179/374 (47%), Positives = 234/374 (62%), Gaps = 14/374 (3%)
Query: 138 LVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFA----GTSV-----LRSLTVST 188
LVF + M E + + ++YV+L + A GT + +++ +
Sbjct: 100 LVFLLFFILMKTSVMKEHHFMAVNYVILFFVASLGILSAPLPLGTPPGYPEHILNMSEGS 159
Query: 189 GACSLFTYVTYATLPVR-LHEATIGGLALAAVNIGAHLLLDNSSDM---QLYCTIATLIA 244
+ + YA +P+R L + GG + + + D+ QL +
Sbjct: 160 WVVAFLVFNVYALMPLRTLSKCLFGGFIPLVHLVVSSQTCRHFPDLHWRQLVANTILFLC 219
Query: 245 CNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI 304
N AG+ TH + QRR F +TRDC+ A SVLP+HVAMEMK DI
Sbjct: 220 ANVAGLFTHNSTDRTQRRTFKDTRDCIAARLDIQDQNEKLERILMSVLPQHVAMEMKNDI 279
Query: 305 ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 364
+ P H FHKIYIQ ++NV+ILFADI GFT LS QCTA+ELVR+LNELF RFD+LA ++
Sbjct: 280 TT-PHHGMFHKIYIQLHDNVTILFADIVGFTCLSSQCTAQELVRILNELFGRFDQLAKQN 338
Query: 365 HCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 424
+C+RIK+LGDCYYCVSGLPEAR +HA CCVEMGLDMIDAIA V + V +NMRVG+HTG
Sbjct: 339 NCMRIKILGDCYYCVSGLPEARANHAACCVEMGLDMIDAIASVCDQTGVKLNMRVGLHTG 398
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYR 484
RV C VLGL+KWQ+DV+SNDV LAN+ME+GG+AGRVHITK TL L Y+VEPG G R
Sbjct: 399 RVLCGVLGLKKWQYDVFSNDVKLANHMEAGGIAGRVHITKSTLDQLHGQYEVEPGRGEER 458
Query: 485 NAYLKDHNIETYLI 498
+AY+K ++T+ I
Sbjct: 459 DAYIKKLGVQTFFI 472
Score = 88.2 bits (209), Expect = 5e-16
Identities = 68/243 (27%), Positives = 109/243 (44%), Gaps = 21/243 (8%)
Query: 251 LTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRH 310
L ++ +E R FL E ++LP HVA + Q
Sbjct: 835 LQNREQEWTLRLDFLWKSQAAEEKAGMQELQRQNSRILCNLLPEHVANHF---LHLQTNS 891
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELFARFDRLAAEHHC 366
++Y Q+Y V++ FA I F+ + A E +R+LNE+ A FD L +
Sbjct: 892 HM--ELYSQQYNKVAVFFASIPNFSDFYVELAANNQGVECLRVLNEIIADFDELLDIPYF 949
Query: 367 L---RIKLLGDCYYCVSGLP-----EARDD----HAKCCVEMGLDMIDAIALVREVMAVN 414
+IK +G CY +GL + R+D + V+ + M + + + E N
Sbjct: 950 YGVEKIKTIGSCYMAATGLKPTHLVKGREDSITFYLTMLVDFVMSMKEKLKNINENSYNN 1009
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
+RVGI+ G V V+G RK Q+D+W N V +A+ MES GV+ ++ +T+E L +
Sbjct: 1010 FELRVGINVGPVVAGVIGARKPQYDIWGNTVNVASRMESTGVSSKIQVTEEVYAVLKSVF 1069
Query: 475 KVE 477
E
Sbjct: 1070 TFE 1072
>UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=29; Euteleostomi|Rep: Adenylate
cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type
VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1251
Score = 339 bits (834), Expect = 9e-92
Identities = 175/319 (54%), Positives = 216/319 (67%), Gaps = 8/319 (2%)
Query: 193 LFT-YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIA--TLIAC-NAA 248
LFT + TY+ LP+ L A + GL + + + +++ + + + +A L C N A
Sbjct: 275 LFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTA 334
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS-Q 307
G+ + AQR+AFLETR CVEA SVLPR V +EM D+ + +
Sbjct: 335 GIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE 394
Query: 308 PRH--EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHH 365
H QFH+IYI RYENVSILFAD+ GFT+LS +A+ELVR+LNELFARFDRLA EHH
Sbjct: 395 DEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHH 454
Query: 366 CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR 425
CLRIK+LGDCYYCVSGLPE R DHA CCVEMGL MI I VR +V+MR+GIH+G
Sbjct: 455 CLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGS 514
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRN 485
V C VLGLRKWQFDVWS DV +AN +ESGG+ GR+HI+K TL CL DY VE GHG RN
Sbjct: 515 VLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERN 574
Query: 486 AYLKDHNIETYLI-VPDDT 503
+L+ HNIETYLI P+D+
Sbjct: 575 EFLRKHNIETYLIKQPEDS 593
Score = 95.9 bits (228), Expect = 3e-18
Identities = 65/196 (33%), Positives = 97/196 (49%), Gaps = 19/196 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + R + ++Y Q Y+ V ++FA I GF Q E
Sbjct: 953 NILPSHVARHF----LEKDRDNE--ELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVE 1006
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-PEARD-----DHAKCCVEM 396
+RLLNE+ A FD L E +IK +G Y VSGL PE + H +
Sbjct: 1007 CLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADF 1066
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L + ++I + + N +R+GI G V V+G +K Q+D+W V LA+ M+S GV
Sbjct: 1067 SLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV 1126
Query: 457 AGRVHITKETLCCLGD 472
+GR+ + +ET L D
Sbjct: 1127 SGRIQVPEETYLILKD 1142
>UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF13838, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1085
Score = 337 bits (829), Expect = 4e-91
Identities = 166/293 (56%), Positives = 199/293 (67%), Gaps = 2/293 (0%)
Query: 214 LALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEA 273
L+LA + L L S L + N +G+ E QR+ FL+ R C+E
Sbjct: 63 LSLAELLSSPRLTLSKGSH-PLAANAVLFASVNLSGVFVRILTERTQRKVFLQARSCIEE 121
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICG 333
S+LPR+VAMEMK D P FHKIYIQR++NVSILFADI G
Sbjct: 122 RLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERI-FHKIYIQRHDNVSILFADIVG 180
Query: 334 FTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCC 393
FTSL+ QCTA+ELV+LLNELF +FD LA E+HC RIK+LGDCYYCVSGL + + DHA CC
Sbjct: 181 FTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHAHCC 240
Query: 394 VEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMES 453
VEMGLDMID IA V E V++NMRVG+HTGRV C VLGLRKWQ+DVWSNDVTLAN ME+
Sbjct: 241 VEMGLDMIDTIASVVEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEA 300
Query: 454 GGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRV 506
GG+ G+VHIT+ TL CL DY+VEPG G R+A+L+ H IETY IVP +V
Sbjct: 301 GGLPGKVHITRTTLECLNGDYEVEPGFGHERHAFLQKHRIETYFIVPSHRRKV 353
Score = 44.8 bits (101), Expect = 0.006
Identities = 18/44 (40%), Positives = 30/44 (68%)
Query: 420 GIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
GI+ G V V+G R+ Q+D+W N V +A+ M+S GV G++ ++
Sbjct: 948 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVS 991
>UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 9
SCAF14991, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1208
Score = 328 bits (805), Expect = 3e-88
Identities = 178/394 (45%), Positives = 239/394 (60%), Gaps = 11/394 (2%)
Query: 123 RVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLR 182
R + V VL ++ +F ++ +R ++ Y+ +SY+V+ ++++ G ++
Sbjct: 180 RAPDVAYVTVLSVAMALFLAMMVVCNRNGFHQDYMWIVSYLVIGVLIVVQVF--GVLMVY 237
Query: 183 SLTVSTGACS--LFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQL-YCTI 239
+ S G F Y+ Y LPVR+ A + G L+ +++ L+ L CT+
Sbjct: 238 PPSASEGIWGTVFFIYIIYTLLPVRMRAAVVSGAVLSVIHVVTAWHLNQDFTFVLKQCTL 297
Query: 240 ATL--IACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXX--XXXSVLPRH 295
+ I L P+ L+ + ++ E ++ H
Sbjct: 298 SRRYHILKPFQRPLRFAPQLLSDSNLWTDSFSGREKHHQNDFLYLYLLSCIKGQALESSH 357
Query: 296 VAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFA 355
+ A P++ F + ++ SILFADI GFTSL+ QCTA+ELV LNELFA
Sbjct: 358 PISSSQCPPARVPQNTSF--LQFRQNLAYSILFADIEGFTSLASQCTAQELVMTLNELFA 415
Query: 356 RFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNV 415
RFD+LA+E+HCLRIK+LGDCYYCVSGLPE R DHA CCVEMG+DMI+AI+LVREV VNV
Sbjct: 416 RFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNV 475
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
NMRVGIH+GRVHC VLGLRKWQFDVWSNDVTLAN ME+GG AGR+HITK TL L DY+
Sbjct: 476 NMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNGDYE 535
Query: 476 VEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
VEPG GG RNAYLK+HNIET+L++ R D+K
Sbjct: 536 VEPGFGGERNAYLKEHNIETFLVLGCSQKRKDEK 569
Score = 85.0 bits (201), Expect = 5e-15
Identities = 58/201 (28%), Positives = 102/201 (50%), Gaps = 19/201 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP+ VA +A + R+++ +Y Q E V+++FA I F+ + A E
Sbjct: 990 NILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASISNFSEFYVELEANNEGVE 1043
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD + +E +IK +G Y SGL ++ D H +
Sbjct: 1044 CLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNDSTYDREGRSHILALADYA 1103
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ + + + + E N M++G++ G V V+G RK Q+D+W N V +A+ M+S GV
Sbjct: 1104 MRLREQMKYINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1163
Query: 458 GRVHITKETLCCL-GDDYKVE 477
+ +T + L + YK++
Sbjct: 1164 DYIQVTTDLYHVLDSNGYKLD 1184
>UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl
cyclase 78C CG10564-PA; n=2; Apocrita|Rep: PREDICTED:
similar to Adenylyl cyclase 78C CG10564-PA - Apis
mellifera
Length = 1299
Score = 326 bits (800), Expect = 1e-87
Identities = 171/321 (53%), Positives = 210/321 (65%), Gaps = 18/321 (5%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIATL-------IAC 245
Y YA LP+ L + G A ++ G LL D + + C + L +A
Sbjct: 237 YAPYAMLPLPLRWCVLAGYGTALTHMVMAGITLLRDPTYLHDITCIVRMLTTNVLLYLAM 296
Query: 246 NAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIA 305
N AGM T + QR+AFLET +E SVLP VA EM DIA
Sbjct: 297 NLAGMYTKYLTDRGQRQAFLETHRSMETRQRTQNENNRQEKLLLSVLPDFVAKEMIRDIA 356
Query: 306 SQPRH--------EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARF 357
+ QFH+IYI RYENVSILFADI GFT+L+ QC+A+ELV++LN+LFARF
Sbjct: 357 RETARGGTISFTPNQFHRIYIHRYENVSILFADIKGFTALASQCSAQELVKVLNDLFARF 416
Query: 358 DRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNM 417
D+L+AE+HCLRIKLLGDCYYC+ GLP AR DHA CCVEMGL MI AI VR V++NM
Sbjct: 417 DKLSAENHCLRIKLLGDCYYCICGLPIARSDHAHCCVEMGLHMIKAIRDVRYTTKVDLNM 476
Query: 418 RVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
R+GIH+G V C VLGLRKWQFDVWS DVTLAN++ESGG+ GRVHI+++TL CL D Y+VE
Sbjct: 477 RIGIHSGSVLCGVLGLRKWQFDVWSYDVTLANHLESGGIPGRVHISEDTLNCLNDVYEVE 536
Query: 478 PGHGGYRNAYLKDHNIETYLI 498
PG+G R+ YLK+ N+ TYLI
Sbjct: 537 PGNGTERDNYLKERNVVTYLI 557
Score = 90.2 bits (214), Expect = 1e-16
Identities = 64/188 (34%), Positives = 100/188 (53%), Gaps = 19/188 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSL--SDQCTAEELV 347
++LP HVA +Q R + +Y Q + V ++FA + FT D E +
Sbjct: 1046 NILPDHVAHHF----LTQDRAPE---LYSQSRDKVGVMFASVPNFTEFYSEDVNKGMECI 1098
Query: 348 RLLNELFARFDRLAAEH--HCL-RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMID-A 403
RLLNE+ A FD L E+ HC+ +IK +G Y SGL ++D K +E ++D A
Sbjct: 1099 RLLNEIIADFDELLDENRFHCIEKIKTVGATYMAASGLNPCQNDKNKDDMEHLCRLVDYA 1158
Query: 404 IALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+A+ + VN++ +RVGI G + V+G RK FD+W N V LA+ M+S GV
Sbjct: 1159 VAMRLRLEDVNIHSFNNFDLRVGISCGPLVGGVIGARKPVFDIWGNTVNLASRMDSTGVM 1218
Query: 458 GRVHITKE 465
G++ + ++
Sbjct: 1219 GKIQVPQD 1226
>UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC
4.6.1.1) (Adenylate cyclase type VIII) (ATP
pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Danio rerio|Rep: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase). - Danio rerio
Length = 888
Score = 322 bits (792), Expect = 1e-86
Identities = 157/273 (57%), Positives = 188/273 (68%), Gaps = 3/273 (1%)
Query: 235 LYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPR 294
L + + N AGM + AQR+AFLETR C+EA SVLPR
Sbjct: 1 LLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPR 60
Query: 295 HVAMEMKADIAS---QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLN 351
V +EM D+ + + QFH+IYI RYENVSILFAD+ GFT+LS +A+ELVR+LN
Sbjct: 61 FVVLEMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLN 120
Query: 352 ELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVM 411
ELFARFDRLA EHHCLRIK+LGDCYYCVSGLPE R DHA CCVEMGL MI I VR
Sbjct: 121 ELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRT 180
Query: 412 AVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLG 471
+++MR+GIH+G V C VLGLRKWQFDVWS DV +AN +ESGG+ GR+HI+K L CL
Sbjct: 181 KHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLN 240
Query: 472 DDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
DY+VE GHG RN +L+ HNIET+LI + S
Sbjct: 241 GDYEVEEGHGKDRNDFLRRHNIETFLIKQPEES 273
Score = 84.2 bits (199), Expect = 8e-15
Identities = 60/204 (29%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + R + ++Y Q Y+ V ++FA I GF Q E
Sbjct: 663 NILPSHVARHF----LEKDRDNE--ELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVE 716
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL------------PEARDDHA 390
+RLLNE+ A FD L E +IK +G Y VSGL + D
Sbjct: 717 CLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMAVSGLLNVYRIWVIGMFKQCEDKWG 776
Query: 391 KCCV--EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLA 448
C + + + ++I + + N +R+G+ G V V+G +K Q+D+W V LA
Sbjct: 777 HLCALADFAIALNESIQEINKHSFNNFQLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLA 836
Query: 449 NYMESGGVAGRVHITKETLCCLGD 472
+ M+S GV+G++ + +ET L +
Sbjct: 837 SRMDSTGVSGKIQLPEETYAILNE 860
>UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG10564-PA - Tribolium castaneum
Length = 1551
Score = 317 bits (779), Expect = 4e-85
Identities = 178/346 (51%), Positives = 213/346 (61%), Gaps = 16/346 (4%)
Query: 169 LLIEFSFAGTSVLRSLTVSTGACSLFT-YVTYATLPVRLHEATIGGLALAA---VNIGAH 224
LL SF G S+ LFT +V YA LP+ L I G A + I
Sbjct: 219 LLTTQSFCGNGFGFSIKEDLVWYVLFTVFVPYAMLPLPLRWCMIAGCLSAVGHIIVISIE 278
Query: 225 LLLDNSSDMQLYCTIATLIA-------CNAAGMLTHQPRELAQRRAFLETRDCVEAXXXX 277
L S C I ++A N AGM T + +QR+AFLET +E
Sbjct: 279 LYTPKSLHDDNECKIRRIVANFLLYVAVNFAGMYTKYLTDRSQRKAFLETHRSMETRYRT 338
Query: 278 XXXXXXXXXXXXSVLPRHVAMEMKADIASQPRH-----EQFHKIYIQRYENVSILFADIC 332
SVLP VA EM DI + R QFHKIYI RYENVSILFADI
Sbjct: 339 QSENDKQEKLLLSVLPDFVAKEMIRDIEREERGGVFQPHQFHKIYIHRYENVSILFADIK 398
Query: 333 GFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKC 392
GFT+L+ QC+A+ELVR+LNELFARFD+LAAE+HCLRIKLLGDCYYCVSGLP R DHA C
Sbjct: 399 GFTALASQCSAQELVRILNELFARFDKLAAENHCLRIKLLGDCYYCVSGLPTPRSDHAHC 458
Query: 393 CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
VEMGL MI AI R V++NMR+GIH+G V C VLGLRKWQFD++S DV LAN+ME
Sbjct: 459 SVEMGLHMIKAIRDTRTKTQVDLNMRIGIHSGSVLCGVLGLRKWQFDIFSYDVRLANHME 518
Query: 453 SGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI 498
SGG+ GRVHI++ T CL Y+VEPG+G R+ YL++H++ TYLI
Sbjct: 519 SGGIPGRVHISEATYQCLNGAYEVEPGNGQERDCYLREHDVTTYLI 564
Score = 84.6 bits (200), Expect = 6e-15
Identities = 71/248 (28%), Positives = 106/248 (42%), Gaps = 23/248 (9%)
Query: 241 TLIACNAAGMLTHQPR--ELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAM 298
T++ C M+ + R E+ R FL + ++LP HVA
Sbjct: 1039 TILLCVFFLMVAYHARLVEVTSRLDFLWKQQAERELNDMEETRHTNTQLLKNILPDHVAQ 1098
Query: 299 EMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSL--SDQCTAEELVRLLNELFAR 356
S R+ + ++Y Q E V +LFA I FT D E +RLLNE+ A
Sbjct: 1099 HF----LSNERNSE--ELYSQSREEVGVLFASIPNFTEFYSEDINKGLECIRLLNEIIAD 1152
Query: 357 FDRLAAEHHCLRIKLLGDC-----YYCVSGL-PEARD-------DHAKCCVEMGLDMIDA 403
FD L E I+ + Y SGL P +D +H ++ + M
Sbjct: 1153 FDELLDEERFSMIEKIKTVSATATYMAASGLNPTHKDALNTDSPEHLCALIDFAIAMRQK 1212
Query: 404 IALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
+ + + N +RVG+ G + C V+G RK FD+W N V A+ M+S GV G++ +
Sbjct: 1213 LDEINKESFNNFGLRVGVSCGSLVCGVIGARKPVFDIWGNTVNEASRMDSTGVIGQIQVP 1272
Query: 464 KETLCCLG 471
K T LG
Sbjct: 1273 KYTAQLLG 1280
>UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 4 -
Caenorhabditis elegans
Length = 954
Score = 308 bits (756), Expect = 3e-82
Identities = 145/274 (52%), Positives = 190/274 (69%)
Query: 226 LLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXX 285
LL S + + + +I N G L + P E QR+ F ETR CV++
Sbjct: 144 LLPMSFMLMILTRVMMVILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQE 203
Query: 286 XXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEE 345
+VLP+++A E+K D+ FHKIYI++YE++SILFADICGFT+L+ + ++
Sbjct: 204 KILLAVLPKNIAFEVKKDMQETHEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKD 263
Query: 346 LVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIA 405
LV +LNELFARFD++A+ H C+RIK+LGDCYYCV G+PE + +HA VEMG DMI+AI
Sbjct: 264 LVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIR 323
Query: 406 LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
LVRE+ VNVNMRVGIHTG+ HC VLGL+KWQFDVWSNDVTLAN MESGG+AGRVHIT
Sbjct: 324 LVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDA 383
Query: 466 TLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
T L Y +E G+GG R+ +L+ I+T+L+V
Sbjct: 384 TRSYLKGAYILEEGNGGSRSKFLEKEKIKTWLVV 417
Score = 83.0 bits (196), Expect = 2e-14
Identities = 57/190 (30%), Positives = 91/190 (47%), Gaps = 20/190 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA D S K+Y + +N I+FA + F +C E
Sbjct: 728 NILPSHVAKHFVEDATS------VSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVE 781
Query: 346 LVRLLNELFARFDRLAAE-------HHCLRIKLLGDCYYCVSGLP--EARDD-HAKCCVE 395
+RLLNE+ + FD++ + +IK + Y SGL E D+ H +
Sbjct: 782 CLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECGDNSHVEAIAL 841
Query: 396 MGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGG 455
+++ + N N+R+GI+ G V V+G K +D+W N V +A+ M+SGG
Sbjct: 842 FARELLVKLESTNIHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGG 901
Query: 456 VAGRVHITKE 465
VAGR+ +T+E
Sbjct: 902 VAGRIQVTEE 911
>UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1246
Score = 307 bits (754), Expect = 5e-82
Identities = 159/347 (45%), Positives = 217/347 (62%), Gaps = 8/347 (2%)
Query: 161 SYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVN 220
S V+++ +++ + G S R+ T V+Y LP+ + G + +
Sbjct: 288 SLVIVIGTIVLANLYFGFSNSRTPTSDIPVLFYTVVVSYMVLPLSRKWTLVSGSVVIVFH 347
Query: 221 I-GAHLLLDNSSDM--QLYCTIATLIACNAAGMLTHQ-PRELAQRRAFLETRDCVEAXXX 276
+ A L SD+ QL+C L + N G LTH+ ++A RRAFL+ R+ V++
Sbjct: 348 LLTAGLCSTTHSDLGLQLFCNFLVLSSANIIG-LTHKFLSDVAHRRAFLDARNSVDSMIK 406
Query: 277 XXXXXXXXXXXXXSVLPRHVAMEMKADIAS---QPRHEQFHKIYIQRYENVSILFADICG 333
S +P ++ E+K D+ +PR FH +Y+QRY VSIL+ADI
Sbjct: 407 LEKEKQQQDELLVSCIPSNLVKEIKKDLQENMREPRPTLFHDLYVQRYHGVSILYADIVN 466
Query: 334 FTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCC 393
FT L+ +CTA ELV++LNELF RFD+LA + C+RIK+LGDCYYCVSG+P A HA C
Sbjct: 467 FTPLASECTAAELVKMLNELFGRFDQLAKKSSCMRIKILGDCYYCVSGIPTADKKHAHNC 526
Query: 394 VEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMES 453
V MGL M+DAI VRE V+V+MR+G+HTG V C VLGLRKWQ+DVWS+DVT+AN MES
Sbjct: 527 VRMGLRMLDAIRDVRENTGVDVDMRIGVHTGSVLCGVLGLRKWQYDVWSDDVTIANNMES 586
Query: 454 GGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVP 500
GGV GRVHI+K+TL CL +Y VEPG GG R+ +L D ++TYL+VP
Sbjct: 587 GGVPGRVHISKQTLDCLDGEYDVEPGLGGERSTFLADTGVDTYLVVP 633
Score = 86.6 bits (205), Expect = 2e-15
Identities = 59/196 (30%), Positives = 98/196 (50%), Gaps = 21/196 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+++P HV + S +HE +Y + YE+VS++FA I F Q + E
Sbjct: 1021 NIIPSHVIAYY---LRSSRKHED---LYHEAYESVSVMFASIPNFKDFYQQTKSNGEGME 1074
Query: 346 LVRLLNELFARFDRLAAE--HHCLRIKLLGDCYYCVSGLPEAR----DDHAK-----CCV 394
+R+LNE+ + FD L + +IK +G Y +GL + DD A V
Sbjct: 1075 CIRVLNEIISDFDLLVIKKFQDVEKIKTIGSTYMAATGLHRGQAGNQDDEAGERTIVTMV 1134
Query: 395 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESG 454
E L M+ + V + N ++R+G++ G V V+G RK Q+D+W + V +A+ M+S
Sbjct: 1135 EFSLAMMSTLDTVNQHSFNNFSLRIGVNHGPVIAGVIGARKPQYDIWGDTVNVASRMDSS 1194
Query: 455 GVAGRVHITKETLCCL 470
G G++ + +ET L
Sbjct: 1195 GEPGKIQMREETAAVL 1210
>UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2;
Sophophora|Rep: Adenylate cyclase type 2 - Drosophila
melanogaster (Fruit fly)
Length = 1307
Score = 297 bits (730), Expect = 4e-79
Identities = 168/391 (42%), Positives = 233/391 (59%), Gaps = 21/391 (5%)
Query: 126 HIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLT 185
H++ ++L L+AL+ +L L PA+ +++ ++ F L + L L
Sbjct: 107 HLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLP 166
Query: 186 VSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLL--DNSSDM-QLYCTIATL 242
+ +LF + ++ LP+ + + L + A++I + D + ++ L+ I L
Sbjct: 167 MY----ALFLCI-HSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVML 221
Query: 243 IACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKA 302
+ + +G+ + A R TR +E SV+P ++A E+K
Sbjct: 222 ASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKR 281
Query: 303 DI------ASQPRHEQ-------FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
I A Q Q FH++++QR+ NV+ILFADI FT LS TA +LV+
Sbjct: 282 SIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKT 341
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN+LF RFD++A E+ CLRIK+LGDCYYCVSGLP +R HA CV MGL MIDAI VRE
Sbjct: 342 LNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVRE 401
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+NV+MR+GIHTG V C VLGLRKWQFDVWS+DVTLAN+MESGGVAGRVHITK+TL
Sbjct: 402 ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDF 461
Query: 470 LGDDYKVEPGHGGYRNAYLKDHNIETYLIVP 500
LGD ++VE G GG R+AYL DH +E+YLIVP
Sbjct: 462 LGDKFEVEQGEGGNRDAYLADHKVESYLIVP 492
Score = 79.4 bits (187), Expect = 2e-13
Identities = 58/186 (31%), Positives = 98/186 (52%), Gaps = 19/186 (10%)
Query: 300 MKADIASQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELF 354
+ A +A+ H E+ ++Y + Y V+++FA I + D+ E +RLLNE+
Sbjct: 1084 LPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEII 1143
Query: 355 ARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDDHA---KCCVEMGLDMID--AIAL 406
FD+L + +IK + Y C SGL ++D A K E + ++ AIAL
Sbjct: 1144 CDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATDEKRTEEHNVVILVEFAIAL 1203
Query: 407 VREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
+ + ++N +R+G++ G V V+G +K Q+D+WSN V +A+ M+S GV GR+
Sbjct: 1204 MSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRL 1263
Query: 461 HITKET 466
T+ T
Sbjct: 1264 QTTENT 1269
>UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whole
genome shotgun sequence; n=3; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14199,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 982
Score = 296 bits (727), Expect = 9e-79
Identities = 170/428 (39%), Positives = 254/428 (59%), Gaps = 35/428 (8%)
Query: 117 IYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFA 176
+ Y +++VA ++ V +GL+A V LL L + ++ + YV+ + + +
Sbjct: 95 VVYTEDKVAMLV-VAAVGLAADVVLYLLCLLQKLPAPLVWRGAVPYVLWLMIAIHVLCYM 153
Query: 177 GTSVLR--SLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLL------- 227
+ R + S G + F++ ++ TLPV L + L L A++ G H+L+
Sbjct: 154 ALNYQRFPHASNSVGWQAFFSFSSFLTLPVNL----VPLLLLTALSCGIHVLVLGVTVTQ 209
Query: 228 --DNSSD-----MQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXX 280
+N+ QL ++ + G++++ + R AFLE R +E
Sbjct: 210 SFENNLQGPMLVRQLLASVMLYLCAAMVGVMSYYMADRKYRMAFLEARRSLEVKLTLEEQ 269
Query: 281 XXXXXXXXXSVLPRHVAMEMKADIASQPRHE----QFHKIYIQRYENVSILFADICGFTS 336
S+LP+H+A EM + +Q + + QF+ +Y+ R+ENVSILFADI GFT
Sbjct: 270 STQQEELLLSILPKHIADEMLQGMKNQAQQQEVQQQFNTMYMYRHENVSILFADIVGFTQ 329
Query: 337 LSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEM 396
LS C+A+ELV+LLNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ RDDHA C + M
Sbjct: 330 LSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDFRDDHAACSIMM 389
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
GL M+DAI+ VRE V+MRVG+HTG V VLG ++WQFDVWS DVTLAN MESGG+
Sbjct: 390 GLAMVDAISYVREKTRTEVDMRVGVHTGTVLGGVLGQKRWQFDVWSTDVTLANKMESGGI 449
Query: 457 AGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQH-SFA 515
GRVHI++ T L ++++EPG+GG R YL + I+TYL++ P+H +
Sbjct: 450 PGRVHISQTTKDSLHGEFELEPGNGGERCEYLLEKGIDTYLVL---------APKHMANG 500
Query: 516 VNGNVSKE 523
+NGNV+++
Sbjct: 501 LNGNVTRQ 508
Score = 72.1 bits (169), Expect = 4e-11
Identities = 64/203 (31%), Positives = 98/203 (48%), Gaps = 37/203 (18%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----- 344
++LP HVA K + ++ R E+ +Y Q Y + ++FA I F SD T E
Sbjct: 734 NMLPEHVA---KHFLGTKKRDEE---LYSQSYSQIGVMFASIPNF---SDFYTEEGINNG 784
Query: 345 --ELVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEARDDHAKCCVEMGL 398
E +R+LNE+ + FD L + +IK +G Y SGL PE + + L
Sbjct: 785 GIECLRILNEIISDFDSLLDKEEFRSITKIKTIGSTYMAASGLTPECHTNGYNKSEDQPL 844
Query: 399 --------DMIDAIALVREVMAVNVN--------MRVGIHTGRVHCVVLGLRKWQFDVWS 442
D+ D AL +V N+N +R+GI+ G V V+G RK +D+W
Sbjct: 845 VEHWRHLSDLAD-FALSMKVTLNNLNKQSFNNFMLRIGINKGGVLAGVIGARKPHYDIWG 903
Query: 443 NDVTLANYMESGGVAGRVHITKE 465
N V +A+ MES GV G + + ++
Sbjct: 904 NTVNVASRMESTGVMGNIQVVED 926
>UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 15
SCAF14542, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 971
Score = 295 bits (725), Expect = 2e-78
Identities = 141/217 (64%), Positives = 167/217 (76%), Gaps = 4/217 (1%)
Query: 290 SVLPRHVAMEMKADIAS-QPRH--EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEEL 346
SVLPR V +EM D+ + + H QFH+IYI RYENVSILFAD+ GFT+LS A+EL
Sbjct: 89 SVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLPAQEL 148
Query: 347 VRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIAL 406
VR+LNELFARFDRLA EHHCLRIK+LGDCYYCVSGLPE R DHA CCVEMGL M+ I
Sbjct: 149 VRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMLKTIRY 208
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
VR +++MR+GIH+G V C VLGLRKWQFDVWS DV +AN +ESGG+ GR+HI+K
Sbjct: 209 VRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAA 268
Query: 467 LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI-VPDD 502
L CL DY+VE GHG RN +L+ HNIET+LI P+D
Sbjct: 269 LDCLNGDYEVEEGHGKDRNDFLRRHNIETFLIRQPED 305
Score = 46.4 bits (105), Expect = 0.002
Identities = 20/51 (39%), Positives = 32/51 (62%)
Query: 420 GIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
G+ G V V+G +K Q+D+W V LA+ M+S GV+G++ + +ET L
Sbjct: 808 GMAQGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQVPEETFLIL 858
Score = 35.9 bits (79), Expect = 2.9
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 10/78 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + R + ++Y Q Y+ V ++FA I F Q E
Sbjct: 613 NILPSHVARHF----LEKDRDNE--ELYSQSYDAVGVMFASIPAFADFYSQTEMNNQGVE 666
Query: 346 LVRLLNELFARFDRLAAE 363
+RLLNE+ A FD + ++
Sbjct: 667 CLRLLNEIIADFDEVRSK 684
Score = 35.5 bits (78), Expect = 3.8
Identities = 18/35 (51%), Positives = 22/35 (62%), Gaps = 1/35 (2%)
Query: 240 ATLIAC-NAAGMLTHQPRELAQRRAFLETRDCVEA 273
A L C N AG+ + AQR+AFLETR C+EA
Sbjct: 18 AVLFMCMNTAGIFISYLSDRAQRQAFLETRRCIEA 52
>UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1285
Score = 295 bits (725), Expect = 2e-78
Identities = 173/420 (41%), Positives = 239/420 (56%), Gaps = 25/420 (5%)
Query: 124 VAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFA--GTSVL 181
+A +I++I+ L + A L + + + + + +++ L SFA T +
Sbjct: 56 LACLISIIMCKLQEEIVADLTMLTGASVVLCVISVALHFPMVMNSPLAALSFAMLTTGTI 115
Query: 182 RSLTVSTGA----CSLFTYV--TYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM-- 233
++ ++ GA LF + + LP+ + + + L V+IG L D+
Sbjct: 116 GAVAIAVGAELAPLPLFALILGVHTMLPISWPVSVVLAVILCLVHIGGRLW-SGVQDLPA 174
Query: 234 ----QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXX 289
QL + L + + +G+ + A A TR +E
Sbjct: 175 YFFPQLVAEMIFLASASISGLYYRIMSDAAHIDAVDGTRIGIEQRVRLECEREQQEQLLL 234
Query: 290 SVLPRHVAMEMKADI----------ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSD 339
SV+P ++A E+K I A +FH++++QR+ NVSIL+ADI FT LS+
Sbjct: 235 SVIPAYIAAEVKRSIMLKMADACQTAGGQSQTRFHEMHVQRHNNVSILYADIVNFTPLSE 294
Query: 340 QCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLD 399
Q TA +LV+ LNELF RFD++A E+ CLRIK+LGDCYYCVSGLP +R HA CV MGL
Sbjct: 295 QLTASDLVKTLNELFGRFDQIAQENQCLRIKILGDCYYCVSGLPVSRPQHAANCVNMGLQ 354
Query: 400 MIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGR 459
MI+AI VRE NV+MR+GIHTG V C VLGLRKWQFDVWS+DVTLAN+MESGGVAGR
Sbjct: 355 MIEAIRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGR 414
Query: 460 VHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGN 519
VHITK TL LGD ++VEPG G R +YL DH IETYLIVP ++ P+ S + N +
Sbjct: 415 VHITKATLDYLGDRFEVEPGGGAGRESYLADHKIETYLIVPPKKQSINDPPKRSPSSNAH 474
Score = 77.8 bits (183), Expect = 7e-13
Identities = 60/201 (29%), Positives = 104/201 (51%), Gaps = 31/201 (15%)
Query: 290 SVLPRHVAME-MKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE---- 344
++LP HVA +K + A Q ++Y + Y +V+++FA I + D+
Sbjct: 1054 NILPAHVAQHFLKKERAVQ-------ELYHESYSSVAVMFASIPNYKEFYDETDVNKQGL 1106
Query: 345 ELVRLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMG---- 397
E +RLLNE+ FD+L + +IK +G Y SGL +++ A E+
Sbjct: 1107 ECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMVASGLRPGKEEGATKNNELDEKRT 1166
Query: 398 -----LDMID-AIALVREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDV 445
+ ++D AIAL+ + +N +R+G++ G V V+G +K Q+D+WSN V
Sbjct: 1167 EEHNVVVLVDFAIALMTALDQINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTV 1226
Query: 446 TLANYMESGGVAGRVHITKET 466
+A+ M+S GV GR+ +++ T
Sbjct: 1227 NVASRMDSCGVMGRIQVSENT 1247
>UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to
ENSANGP00000010056; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010056 - Nasonia
vitripennis
Length = 947
Score = 295 bits (724), Expect = 2e-78
Identities = 150/325 (46%), Positives = 208/325 (64%), Gaps = 17/325 (5%)
Query: 200 ATLP-VRLHEATIGGLALAAVNIGAHLLLDN---SSDMQLY---CTIATLIACNAAGMLT 252
ATLP VR H ++ G LAA+ +++ +++Y + ++ AG+
Sbjct: 57 ATLPRVRRHRPSLVGFCLAALYFIKRIVVYTMVYDEQLKVYEVESDVFFVLTALIAGLYY 116
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI-------- 304
A R+ F T+ +E+ SV+P ++A E+K I
Sbjct: 117 RVLTSRAHRQTFASTKTIIESRIKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADAC 176
Query: 305 --ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
S+ + +FH++Y+QR+ NVSIL+ADI FT LS+Q +A +LV+ LNELF RFD++A
Sbjct: 177 QEVSKHKQTRFHEMYVQRHNNVSILYADIVNFTPLSEQLSASDLVKTLNELFGRFDQIAQ 236
Query: 363 EHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIH 422
++ C+RIK+LGDCYYCVSGLP +R +HA CV MGL MI+AI VRE NV+MR+GIH
Sbjct: 237 DNQCMRIKILGDCYYCVSGLPVSRPNHAYNCVNMGLQMIEAIRFVREATGFNVDMRIGIH 296
Query: 423 TGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGG 482
TG V C VLGLRKWQFDVWS+DVTLAN+MESGG+ G+VH+TK TL LGD ++VEPG+GG
Sbjct: 297 TGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGKVHVTKATLLQLGDRFEVEPGNGG 356
Query: 483 YRNAYLKDHNIETYLIVPDDTSRVD 507
R AYL +H +ET+LI+P ++ D
Sbjct: 357 SREAYLAEHKVETFLIIPPKKNKED 381
Score = 71.7 bits (168), Expect = 5e-11
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 27/197 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA +A++ + +H + Y +++++FA I + D+ E
Sbjct: 717 NILPAHVAGHF---LATRENQDLYH----ESYNSIAVMFASIPNYKEFYDETDINKQGLE 769
Query: 346 LVRLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGLPEARDD-------------H 389
+RLLNE+ FD+L + +IK +G Y GL ++D +
Sbjct: 770 CLRLLNEIICDFDKLLLKPKYSSIEKIKTIGSTYMLACGLSPGKEDGDGLIDLTKQREHN 829
Query: 390 AKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLAN 449
VE + + + + +R+G++ G V V+G +K Q+D+W N V +A+
Sbjct: 830 VIVLVEFAISLTTLLDQINRESFQRFKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVAS 889
Query: 450 YMESGGVAGRVHITKET 466
M+S G G++ +T++T
Sbjct: 890 RMDSCGEMGKIQVTEDT 906
>UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl
cyclase 76E CG7978-PA; n=1; Apis mellifera|Rep:
PREDICTED: similar to Adenylyl cyclase 76E CG7978-PA -
Apis mellifera
Length = 969
Score = 293 bits (719), Expect = 8e-78
Identities = 160/359 (44%), Positives = 217/359 (60%), Gaps = 16/359 (4%)
Query: 167 AFLLIEFSFAGTSVLRSLTVSTGACSLFT-YVTYATLPVRLHEA-TIGGLALAAVNIGAH 224
A LLI F +G + +L + T + A LP + TI + L +++
Sbjct: 97 ARLLIGFVASGILGIGALIIRASVPLFITIHAMIAVLPRDTRQTPTIFAIILIIIHLSIR 156
Query: 225 LL-LDNSSDMQLYCTIATLIACNAA---GMLTHQPRELAQRRAFLETRDCVEAXXXXXXX 280
+ LD+SS Q+ T + +I A G A R F T+ +E+
Sbjct: 157 FIFLDHSSYYQIVQTCSEIIFLFTAILSGSYYSILTAKAHNRTFARTKTVIESRIKLECE 216
Query: 281 XXXXXXXXXSVLPRHVAMEMKADI----------ASQPRHEQFHKIYIQRYENVSILFAD 330
SV+P ++A E+K I S + +F+++Y+QR+ NVSIL+AD
Sbjct: 217 REQQEQLLLSVIPAYIAAEVKRGIMLKMANACQEVSNHKQTRFYEMYVQRHNNVSILYAD 276
Query: 331 ICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHA 390
I FT LS+Q +A LV++LNELF RFD++A ++ C+RIK+LGDCYYCVSGLP +R +HA
Sbjct: 277 IVNFTPLSEQLSASSLVKILNELFGRFDQIAQDNQCMRIKILGDCYYCVSGLPISRPNHA 336
Query: 391 KCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANY 450
CV MGL MIDAI VRE NV+MR+GIHTG V C VLGLRKWQFDVWS+DVTLAN+
Sbjct: 337 YNCVTMGLQMIDAIKFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANH 396
Query: 451 MESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
MESGG+ GRVHITK TL LG+ ++VEPG+GG R YL HNIET+LI+P + + + +
Sbjct: 397 MESGGLPGRVHITKATLLQLGNRFEVEPGNGGSREVYLAQHNIETFLIIPPEKTNQENR 455
Score = 79.8 bits (188), Expect = 2e-13
Identities = 52/195 (26%), Positives = 94/195 (48%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA ++ + +Y +RY +++++FA I + D+ E
Sbjct: 740 NILPAHVAEHFLTNVRA------IQDLYHERYSSIAVMFASIPNYKEFYDETDINKQGLE 793
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDDHAK----------- 391
+RLLNE+ FD+L + +IK +G Y SGL +D K
Sbjct: 794 CLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMLASGLSPGKDTDEKELLKQENHNII 853
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+E L ++ + + + +R+G++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 854 ILIEFALALMTILDQINKESFQKFKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRM 913
Query: 452 ESGGVAGRVHITKET 466
+S G G+V +T++T
Sbjct: 914 DSCGEMGKVQVTEDT 928
>UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate
cyclase 2; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Adenylate cyclase 2 -
Strongylocentrotus purpuratus
Length = 889
Score = 291 bits (714), Expect = 3e-77
Identities = 146/275 (53%), Positives = 187/275 (68%), Gaps = 13/275 (4%)
Query: 243 IACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKA 302
+ N G+ ++AQRR FL+TR C+E+ SVLP H+A EMK
Sbjct: 3 VCVNFIGVCHKHLLDVAQRRTFLDTRSCIESRIKLEHEQAQQERLLLSVLPAHLAYEMKT 62
Query: 303 DIASQPR--------HE-----QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++ ++ R H FH +Y++R++NVSIL+ADI GFT+L+ +C+ ELV+
Sbjct: 63 EMMARVRDPTMSPISHRPSSSTHFHSLYVKRHKNVSILYADIVGFTALASECSPPELVKT 122
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNELF RFD+LA E C+RIK+LGDCYYCVSGLP +R HA CVEMGL M +AI VR+
Sbjct: 123 LNELFGRFDQLAEEFDCMRIKILGDCYYCVSGLPISRPTHAINCVEMGLAMCEAIKTVRD 182
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+V+VNMRVG+HTG V C VLGLRKWQ+DVWS+DVTLAN+MES GV GRVHIT+ TL
Sbjct: 183 ATSVDVNMRVGVHTGNVLCGVLGLRKWQYDVWSHDVTLANHMESCGVPGRVHITQATLDN 242
Query: 470 LGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
LG Y+VEPG G R+ YL+D NIET+ IV +S
Sbjct: 243 LGLKYEVEPGRGHERSEYLRDMNIETFFIVNPKSS 277
Score = 80.2 bits (189), Expect = 1e-13
Identities = 57/192 (29%), Positives = 100/192 (52%), Gaps = 22/192 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + + + + +H Q Y ++++FA I F + E
Sbjct: 657 NMLPSHVAQHF---VKQRMKSDLYH----QSYNLIAVMFASIPNFKEFYTETDVNNEGLE 709
Query: 346 LVRLLNELFARFDRLAAE--HHCL-RIKLLGDCYYCVSGL--PEARDDHAKCCVEMGLDM 400
+RLLNE+ A FD L ++ + C+ +IK +G Y +GL PE+ + +G+
Sbjct: 710 CLRLLNEIIADFDELLSKPKYSCVEKIKTIGSTYMSAAGLKQPESGVSTKQSLYYVGVLT 769
Query: 401 IDAIALVREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESG 454
A+AL ++ +N +R+GI+ G V V+G RK Q+D+W N V +A+ M++
Sbjct: 770 EFAMALQDKLEQLNKQAFNDFKLRIGINHGPVVAGVIGARKPQYDIWGNTVNVASRMDTT 829
Query: 455 GVAGRVHITKET 466
G+ G + +T+ET
Sbjct: 830 GMIGEIQVTEET 841
>UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21;
Theria|Rep: Adenylate cyclase type 3 - Homo sapiens
(Human)
Length = 1144
Score = 291 bits (713), Expect = 4e-77
Identities = 158/390 (40%), Positives = 231/390 (59%), Gaps = 18/390 (4%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAM--NEIYLLTISYVVLVAFLLIEFSFAGTSVLRSL 184
+ ++ V G+ LV +L L + + + + + YV+ + FS+ G + R+
Sbjct: 105 LASLAVAGIG-LVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAH 163
Query: 185 TVS--TGACSLFTYVTYATLPVRLHEATIGGLALAAVN---IGAHLLLDNSSDM------ 233
S G F + + TLP+ L I + V+ +G + ++
Sbjct: 164 AASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLL 223
Query: 234 -QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVL 292
++ + + A G++++ + R+AFLE R +E S+L
Sbjct: 224 REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283
Query: 293 PRHVAMEMKADIA---SQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
P+HVA EM D+ SQ +QF+ +Y+ R+ENVSILFADI GFT LS C+A+ELV+L
Sbjct: 284 PKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKL 343
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ R+DHA C + MGL M++AI+ VRE
Sbjct: 344 LNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVRE 403
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
V+MRVG+HTG V VLG ++WQ+DVWS DVT+AN ME+GG+ GRVHI++ T+ C
Sbjct: 404 KTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDC 463
Query: 470 LGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
L ++ VEPG GG R YL++ IETYLI+
Sbjct: 464 LKGEFDVEPGDGGSRCDYLEEKGIETYLII 493
Score = 72.9 bits (171), Expect = 2e-11
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 894 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 948 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 1008 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1067
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 1068 VNVASRMESTGVMGNIQVVEET 1089
>UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate
cyclase 8; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to adenylate cyclase 8 - Tribolium castaneum
Length = 912
Score = 290 bits (712), Expect = 6e-77
Identities = 152/314 (48%), Positives = 204/314 (64%), Gaps = 8/314 (2%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNIGAHLL--LDNSSDM-QLYCTIATLIACNAAGMLT 252
+V Y P+ L A + G V+I +L L+N+ D+ + C N AG
Sbjct: 7 FVPYTLFPLSLLWALVLGSTSFMVHIILIVLYKLENNFDLKETACDGVFFFTVNFAGAYI 66
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRH-- 310
+ +QRR+F++T +E S+LP VA EM ADI ++ R
Sbjct: 67 KILTDGSQRRSFVQTLRFLENRFKAQQENEKQVQLIFSILPDFVAKEMFADIENEERRGS 126
Query: 311 ---EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 367
+QFHKIYI +Y NVSILFADI GFT+L+ +CTA+ELVR LN+LFARFD+LA +H CL
Sbjct: 127 VQPQQFHKIYIHKYNNVSILFADIKGFTALASKCTAQELVRNLNDLFARFDKLATKHDCL 186
Query: 368 RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVH 427
RIKLLGDCYYCVSGLP AR+DHA C VEMGL+MI AI + V+++MR+GIH+G V
Sbjct: 187 RIKLLGDCYYCVSGLPNAREDHADCAVEMGLNMIKAIKDTKTKTQVDIDMRIGIHSGSVL 246
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAY 487
C VLGLRKWQFD+WS+DV +AN ME+ G+AGRVHI+ TL L +++VE HG +++
Sbjct: 247 CGVLGLRKWQFDIWSHDVKIANRMEATGIAGRVHISDATLRALTKEFRVEAAHGREKDSL 306
Query: 488 LKDHNIETYLIVPD 501
L+ ++I+TY I+ D
Sbjct: 307 LRKNDIQTYFILED 320
Score = 79.8 bits (188), Expect = 2e-13
Identities = 57/191 (29%), Positives = 91/191 (47%), Gaps = 20/191 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
+VLP HVA K ++ + R+E+ +Y Q + + +LFA I F+ + E +RL
Sbjct: 656 NVLPEHVA---KHFLSREYRNEE---LYSQARDGIGVLFATIPNFSKFYSEAKGLECLRL 709
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDC-----YYCVSGL-PEARDD--------HAKCCVE 395
LNE+ A FD + + I+ + Y VSGL P + D H ++
Sbjct: 710 LNEIIATFDEVLDDERFSSIEKIKTVSATATYMAVSGLNPSIKHDPLIGDTPEHLGALID 769
Query: 396 MGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGG 455
+ + + + N+RVGI G + C V+G +K FDVW N V A+ M+S G
Sbjct: 770 FAITLRQRLEEINRDSFNRFNLRVGISYGDLVCGVIGAKKPIFDVWGNTVNEASRMDSTG 829
Query: 456 VAGRVHITKET 466
+ G + + K T
Sbjct: 830 LMGEIQVPKNT 840
>UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000010056 - Anopheles gambiae
str. PEST
Length = 881
Score = 290 bits (712), Expect = 6e-77
Identities = 138/213 (64%), Positives = 163/213 (76%), Gaps = 2/213 (0%)
Query: 290 SVLPRHVAMEMK--ADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELV 347
SV+P ++A EM A +FH++++QR+ NVSIL+ADI FT LS+Q TA +LV
Sbjct: 97 SVIPAYIAAEMADACQRAGGQTQTRFHEMHVQRHNNVSILYADIVNFTPLSEQLTASDLV 156
Query: 348 RLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALV 407
+ LNELF RFD++A E+ CLRIK+LGDCYYCVSGLP +R HA CV MGL MIDAI V
Sbjct: 157 KTLNELFGRFDQIAQENQCLRIKILGDCYYCVSGLPVSRPHHAANCVNMGLQMIDAIRFV 216
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
RE NV+MR+GIHTG V C VLGLRKWQFDVWS+DVTLAN+MESGGVAGRVHITK TL
Sbjct: 217 REATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKATL 276
Query: 468 CCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVP 500
LGD ++VEPG G R +YL DH IETYLIVP
Sbjct: 277 DYLGDMFEVEPGGGASRESYLADHKIETYLIVP 309
Score = 87.8 bits (208), Expect = 7e-16
Identities = 58/190 (30%), Positives = 98/190 (51%), Gaps = 20/190 (10%)
Query: 290 SVLPRHVAME-MKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE---- 344
++LP HVA +K + A Q ++Y + Y +V+++FA I + D+
Sbjct: 668 NILPAHVAQHFLKKERAVQ-------ELYHESYSSVAVMFASIPNYKEFYDETDVNKQGL 720
Query: 345 ELVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDDHAK-----CCVEM 396
E +RLLNE+ FD+L + +IK +G Y SGL +++ A VE
Sbjct: 721 ECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMIASGLRPGKEEGATEHNVVVLVEF 780
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+ ++ A+ + +R+G++ G V V+G +K Q+D+WSN V +A+ M+S GV
Sbjct: 781 AIALMTALDQINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGV 840
Query: 457 AGRVHITKET 466
GRV +T+ T
Sbjct: 841 MGRVQVTENT 850
>UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep:
Adcy3 protein - Mus musculus (Mouse)
Length = 1005
Score = 289 bits (708), Expect = 2e-76
Identities = 161/362 (44%), Positives = 219/362 (60%), Gaps = 18/362 (4%)
Query: 173 FSFAGTSVLRSLTVS--TGACSLFTYVTYATLPVRLHEATIGGLALAAVN---IG---AH 224
FS+ G + R+ S G + F + + TLP+ L I + V+ +G A
Sbjct: 152 FSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQ 211
Query: 225 LLLDNSSDMQLYCTIAT---LIACNA-AGMLTHQPRELAQRRAFLETRDCVEAXXXXXXX 280
D MQL I L C G++++ + R+AFLE R +E
Sbjct: 212 QQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQ 271
Query: 281 XXXXXXXXXSVLPRHVAMEMKADIA---SQPRHEQFHKIYIQRYENVSILFADICGFTSL 337
S+LP+HVA EM D+ SQ +QF+ +Y+ R+ENVSILFADI GFT L
Sbjct: 272 SQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQL 331
Query: 338 SDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMG 397
S C+A+ELV+LLNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ R+DHA C + MG
Sbjct: 332 SSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMG 391
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
L M++AI+ VRE V+MRVG+HTG V VLG ++WQ+DVWS DVT+AN ME+GG+
Sbjct: 392 LAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIP 451
Query: 458 GRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVN 517
GRVHI++ T+ CL ++ VEPG GG R YL + IETYLI+ S+ + K +N
Sbjct: 452 GRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLII---ASKPEVKKTAQNGLN 508
Query: 518 GN 519
G+
Sbjct: 509 GS 510
Score = 39.5 bits (88), Expect = 0.23
Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGF----TSLSDQCTAEE 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F T S E
Sbjct: 895 NMLPEHVARHF---LGSKKRDEE---LYSQSYDEIGVMFASLPNFADFYTEESINNGGIE 948
Query: 346 LVRLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL 382
+R LNE+ + FD L +IK +G Y SG+
Sbjct: 949 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGV 988
>UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=7; Clupeocephala|Rep: Chromosome 14
SCAF15003, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1077
Score = 285 bits (699), Expect = 2e-75
Identities = 158/341 (46%), Positives = 205/341 (60%), Gaps = 31/341 (9%)
Query: 193 LFT-YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATLIAC---NAA 248
LFT + TY LP+ L A G + +++ L+ + L A + C N A
Sbjct: 139 LFTLFATYTLLPLPLLWAMCAGSLTSLLHLVVELIRSYDDVVLLKKVFAKGLLCLGMNTA 198
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKAD---IA 305
G+ H + AQR+ FLETR C+E S+LPR VA+EM AD +
Sbjct: 199 GLFIHYLTDHAQRQVFLETRRCIEGRLKLEQENQRQERLVLSILPRFVALEMIADMNCLE 258
Query: 306 SQPRHEQFHKIYIQRYENV------------------------SILFADICGFTSLSDQC 341
+ ++FHKIYI +Y++V SILFADI GFT LS
Sbjct: 259 DELSPQEFHKIYIHQYKDVRYVHSLYSSSPRLLAWFPHSSGLCSILFADIKGFTLLSMNL 318
Query: 342 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMI 401
+A++LVR LNELF RFDRLA EHHCLRIK+LGDCYYCVSG+PE + HA+ CVEMGL MI
Sbjct: 319 SAQDLVRTLNELFGRFDRLAEEHHCLRIKILGDCYYCVSGVPEPQRAHARHCVEMGLAMI 378
Query: 402 DAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVH 461
+ I VR+ + V+MR+GIH+G V C VLGL+KWQFDVWS DV +AN +E+GG+ GR+H
Sbjct: 379 NTIRYVRKQLKFEVDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIH 438
Query: 462 ITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDD 502
I++ TL CL YK E G G RN +L HNI+T+LI PD+
Sbjct: 439 ISRATLDCLEGTYKTEDGRGRDRNEFLLKHNIDTFLICPDE 479
Score = 93.5 bits (222), Expect = 1e-17
Identities = 62/190 (32%), Positives = 93/190 (48%), Gaps = 19/190 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA R + ++Y Q Y+ V ++FA I GF +Q + +
Sbjct: 818 NILPVHVARHFL------DRSKNDEELYSQSYDEVGVMFASIAGFNEYFEQKEIKHEGVD 871
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARD------DHAKCCVEM 396
+RLLNE+ A FD L E + +IK +G CY SGL R +H V
Sbjct: 872 CLRLLNEIIAGFDELLEESYFSYVEKIKTIGSCYMAASGLAPDRQVSMDEWNHLSELVLF 931
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L M + + + N +RVGI G V V+G K Q+D+W + V LA+ M+S GV
Sbjct: 932 ALAMQETLKEINRHSTKNFQLRVGIAHGPVVAGVIGATKPQYDIWGSTVNLASRMDSTGV 991
Query: 457 AGRVHITKET 466
+GR+ + + T
Sbjct: 992 SGRIQVPEAT 1001
>UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1212
Score = 285 bits (699), Expect = 2e-75
Identities = 162/385 (42%), Positives = 225/385 (58%), Gaps = 12/385 (3%)
Query: 123 RVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLR 182
+V+ +I V G L+ L A PA L + ++ + + LL++ G L
Sbjct: 156 QVSRLIVTGVYGAFYLLLVVLYASKLYPARLMKCLPYLVWLGIFSQLLVD-QVLGYDPLT 214
Query: 183 SLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNI---GAHLLLD-NSSDMQLYCT 238
+ S G + F++++Y LP RL + + ++ ++ G ++ N QL
Sbjct: 215 P-SDSVGMFAFFSFISYVMLPARLALCAVFAIMISIAHLVVAGTQARMNLNYLGQQLVAN 273
Query: 239 IATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAM 298
+ N G + + + QRR+ LETR+ +E SVLP+HVA
Sbjct: 274 TLVFVCANILGAIDYHIADRKQRRSVLETRESLEVKLTLDAQNQQQRRLLLSVLPKHVAE 333
Query: 299 EMKADIASQPR----HEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELF 354
EM D F K++I+ ++ SILFADI GFT LS +CTAE+L+ LNELF
Sbjct: 334 EMTKDFEGDGNPALTDNAFKKLFIRTHDTCSILFADIVGFTELSSKCTAEQLIVTLNELF 393
Query: 355 ARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAV- 413
A FD+LAA++HCLRIK+LGDCYYC+SGL ++ + HA C V MGLDM++ IA VRE V
Sbjct: 394 ANFDKLAAKNHCLRIKILGDCYYCISGLDDSCN-HALCAVNMGLDMVEHIAHVREEKGVK 452
Query: 414 NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
++NMRVGIHTG V VLG RKWQF+ WSNDVTLAN+MESGG+ GRVHI++ TL + D
Sbjct: 453 SLNMRVGIHTGMVLAGVLGQRKWQFEAWSNDVTLANHMESGGIPGRVHISEPTLNSIKDY 512
Query: 474 YKVEPGHGGYRNAYLKDHNIETYLI 498
++VE G GG R+ YL D I+TYLI
Sbjct: 513 FEVEDGDGGSRDDYLADKKIKTYLI 537
Score = 78.6 bits (185), Expect = 4e-13
Identities = 51/163 (31%), Positives = 81/163 (49%), Gaps = 12/163 (7%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELFARFDRLAAEHHCL---R 368
+Y Y+ VS++FA I F+ + E +RLLNE+ FD + A+ L +
Sbjct: 889 LYSHSYKRVSVMFASIPNFSEFYSEDNINNGGVECIRLLNEVITDFDEVLADPRFLGVEK 948
Query: 369 IKLLGDCYYCVSGL-PEARD----DHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
IK + Y SGL PE+ D + V+ L + D + + + +RVGI
Sbjct: 949 IKTISSTYMAASGLRPESEDAEESQNLVDIVDFALTLRDKLDFINQESFNQFVLRVGICQ 1008
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G + V+G +K +D+W N V +A+ ME+ G AG + IT +T
Sbjct: 1009 GPIVAGVIGAKKPHYDIWGNTVNVASRMETTGKAGCIQITAQT 1051
>UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=1;
Xenopus tropicalis|Rep: Adenylate cyclase type 1 (EC
4.6.1.1) (Adenylate cyclase type I) (ATP
pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 781
Score = 283 bits (694), Expect = 9e-75
Identities = 127/176 (72%), Positives = 147/176 (83%)
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SILFADI GFTSL+ QCTA+ELV+LLNELF +FD LA E+HC RIK+LGDCYYCVSGL +
Sbjct: 1 SILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQ 60
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
+ DHA CCVEMGLDMID I V E V++NMRVG+HTGRV C VLGLRKWQ+DVWSND
Sbjct: 61 PKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSND 120
Query: 445 VTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVP 500
VTLAN ME+GG+ G+VHITK TL CL DY+VEPG+G RN++LK HNIET+ IVP
Sbjct: 121 VTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLKKHNIETFFIVP 176
Score = 83.4 bits (197), Expect = 1e-14
Identities = 60/192 (31%), Positives = 91/192 (47%), Gaps = 23/192 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 559 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVE 612
Query: 346 LVRLLNELFARFDRLAAEHHCLR----IKLLGDCYYCVSGLPEARDDHAKCCV------- 394
+RLLNE+ A FD L E C + IK +G Y GL AK +
Sbjct: 613 CLRLLNEIIADFDELM-EKECYKDIEKIKTIGSTYMGAVGLVPTTGTKAKKSIYSHLSTL 671
Query: 395 -EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMES 453
+ ++M D + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S
Sbjct: 672 ADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDS 731
Query: 454 GGVAGRVHITKE 465
GV G++ +T++
Sbjct: 732 TGVQGKIQVTED 743
>UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC
4.6.1.1) (Adenylate cyclase type VIII) (ATP
pyrophosphate-lyase 8) (Adenylyl cyclase 8)
(Ca(2+)/calmodulin- activated adenylyl cyclase).; n=4;
Clupeocephala|Rep: Adenylate cyclase type 8 (EC 4.6.1.1)
(Adenylate cyclase type VIII) (ATP pyrophosphate-lyase
8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated
adenylyl cyclase). - Takifugu rubripes
Length = 1020
Score = 281 bits (689), Expect = 4e-74
Identities = 161/388 (41%), Positives = 227/388 (58%), Gaps = 34/388 (8%)
Query: 142 CLLACLSRPAMNEIYLLTISYVVLVA-FLLIEFSFAGTSVLRSLTVSTGAC-SLFTYVTY 199
C+L + M + L + Y+ +V+ F I G + S C SLF+ TY
Sbjct: 88 CVLVLTRKEVMMSV--LWLRYLSVVSWFSQILQVLVGAFIWAESDHSWYVCFSLFS--TY 143
Query: 200 ATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIACNAAGMLTHQP 255
LP+ L + + G + +++ + + D+ + + + +A N AG+ H
Sbjct: 144 TLLPLPLLWSIVAGTITSILDLVLDVF-SHYGDLAIVRKVLSKALLYLAMNTAGLSIHYL 202
Query: 256 RELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRH---EQ 312
+ QR++FLETR C+E S+LPR + ++M D+A + +Q
Sbjct: 203 SDRTQRQSFLETRRCIEGRVRLERENQRQERLVMSILPRFLVLDMIGDMAPIDDYLLPQQ 262
Query: 313 FHKIYIQRYENV--------------------SILFADICGFTSLSDQCTAEELVRLLNE 352
FHKIYI Y++V SILFADI GFTSLS +A+ELVR LNE
Sbjct: 263 FHKIYIHHYKDVRHLCAFFVMFEIHHRLALFCSILFADIIGFTSLSLILSAQELVRTLNE 322
Query: 353 LFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMA 412
LF RFDRLA EH CLRIK+LGDCYYCVSG+PE + HA+CCV+MGL MI+AI +R +
Sbjct: 323 LFGRFDRLAEEHRCLRIKILGDCYYCVSGVPEPQRGHARCCVDMGLSMINAIRYIRREIQ 382
Query: 413 VNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
+ ++MR+G+H+G V C VLGL+KWQFD+WS DV +AN +E+ GV GRVHI++ TL CLG
Sbjct: 383 LELDMRIGVHSGSVLCGVLGLQKWQFDIWSWDVDIANSLEAAGVPGRVHISRATLDCLGG 442
Query: 473 DYKVEPGHGGYRNAYLKDHNIETYLIVP 500
Y+ E GHG R+ +L+ HNI+TYL+ P
Sbjct: 443 IYETEVGHGQDRSEFLRKHNIDTYLVHP 470
Score = 87.8 bits (208), Expect = 7e-16
Identities = 61/194 (31%), Positives = 90/194 (46%), Gaps = 19/194 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEE---- 345
++LP HVA R ++Y Q YE V +LFA + GF+ +Q A +
Sbjct: 807 NILPAHVAQHFLE------RDRNNEELYSQSYERVGVLFASLPGFSDYYEQKEAADQHFG 860
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDD------HAKCCVEM 396
+RLLN + FD L E + +IK +G Y SGL R + H V
Sbjct: 861 CLRLLNHIITDFDELLDESYFQDVEKIKTMGSSYMAASGLSPDRQECEDGWHHLSELVLF 920
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L M + + + + +RVGI G V V+G K Q+D+W V +A+ MES GV
Sbjct: 921 ALSMQETLKHINTDTGNSFQLRVGIAHGPVIAGVIGATKPQYDIWGTTVNVASRMESTGV 980
Query: 457 AGRVHITKETLCCL 470
+G + + + T C L
Sbjct: 981 SGMIQVPESTSCIL 994
>UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain
adenylate cyclase 1; n=1; Canis lupus familiaris|Rep:
PREDICTED: similar to brain adenylate cyclase 1 - Canis
familiaris
Length = 1161
Score = 277 bits (680), Expect = 4e-73
Identities = 124/181 (68%), Positives = 145/181 (80%)
Query: 326 ILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEA 385
ILFADI GFT L+ QCTA+ELV+LLNELF +FD LA E+HC RIK+LGDCYYCVSGL +
Sbjct: 229 ILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQP 288
Query: 386 RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDV 445
+ DHA CCVEMGLDMID I V E V++NMRVG+HTGRV C VLGLRKWQ+DVWSNDV
Sbjct: 289 KTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDV 348
Query: 446 TLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSR 505
TLAN ME+ G+ G+VHIT+ TL CL DY+VE GHG RN++LK HNIET+ IVP +
Sbjct: 349 TLANVMEAAGLPGKVHITRTTLACLNGDYEVEEGHGHKRNSFLKAHNIETFFIVPSHQRK 408
Query: 506 V 506
V
Sbjct: 409 V 409
Score = 87.4 bits (207), Expect = 9e-16
Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 872 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFDDFYIELDGNNMGVE 925
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEAR-----DDHAKCCVEMG 397
+RLLNE+ A FD L + +IK +G Y GL H +
Sbjct: 926 CLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTTGTKCISSHLSTLADFA 985
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
++M D + + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S GV
Sbjct: 986 IEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1045
Query: 458 GRVHITKE 465
GR+ +T+E
Sbjct: 1046 GRIQVTEE 1053
>UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73;
Euteleostomi|Rep: Adenylate cyclase type 4 - Homo
sapiens (Human)
Length = 1077
Score = 274 bits (671), Expect = 5e-72
Identities = 155/386 (40%), Positives = 217/386 (56%), Gaps = 16/386 (4%)
Query: 140 FACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTY 199
F+ LL SR + + +S +V VA L + +F T + S + Y
Sbjct: 72 FSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAY 131
Query: 200 ATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIAT---LIAC-NAAGMLT 252
A LP+ + +A + GLA + ++ G +L S L +A L C N AG+
Sbjct: 132 AMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYH 191
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI-------- 304
E A R F E + + S+LP ++A EMKA+I
Sbjct: 192 KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
Query: 305 ASQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
S+P FH +Y++R++ VS+L+ADI GFT L+ +C+ +ELV +LNELF +FD++A E
Sbjct: 252 GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
H C+RIK+LGDCYYCVSGLP + DHA CV MGLDM AI +R V++NMRVG+H+
Sbjct: 312 HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT TL L Y VE +
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
Query: 484 RNAYLKDHNIETYLIVPDDTSRVDKK 509
R+ YL++ TYL++ D+K
Sbjct: 432 RDPYLRELGEPTYLVIDPRAEEEDEK 457
Score = 92.7 bits (220), Expect = 2e-17
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 24/199 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + I R+E +Y Q YE V +LFA + F + E
Sbjct: 844 NVLPAHVAPQF---IGQNRRNED---LYHQSYECVCVLFASVPDFKEFYSESNINHEGLE 897
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PEARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL +A+ D + C +G
Sbjct: 898 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLG 957
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A+AL ++ +N + +RVG++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 958 TMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRM 1017
Query: 452 ESGGVAGRVHITKETLCCL 470
ES GV G++ +T+ET L
Sbjct: 1018 ESTGVLGKIQVTEETAWAL 1036
>UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4;
Sophophora|Rep: Adenylyl cyclase 78C-L - Drosophila
melanogaster (Fruit fly)
Length = 1718
Score = 272 bits (667), Expect = 2e-71
Identities = 144/320 (45%), Positives = 198/320 (61%), Gaps = 17/320 (5%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSD----------MQLYCTIATLIAC 245
+V YA LP+ L +GG A+ ++ ++ Q++ A
Sbjct: 433 FVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAI 492
Query: 246 NAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI- 304
N AGM T + QR AF+ET +E S+LP V ++++++
Sbjct: 493 NVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMY 552
Query: 305 -ASQPRHE-QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
+ P E QF+K+Y+ +NVSILFADI GFT L+ + +A++LV++LN+LFARFDR+A
Sbjct: 553 KGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAE 612
Query: 363 EHHCLRIKLLGDCYYCVSGLP----EARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMR 418
++HCLR+KLLGDCYYCVS + R DHA C VE GL MI AI VR V++NMR
Sbjct: 613 DNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMR 672
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
+GIH+G V C VLG +KW FDVWSNDV +AN+MESGG+ GRVHI++ TL CL D Y+VEP
Sbjct: 673 IGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEP 732
Query: 479 GHGGYRNAYLKDHNIETYLI 498
G+GG R+ +LK N++TYLI
Sbjct: 733 GNGGCRDNHLKMLNVKTYLI 752
Score = 66.5 bits (155), Expect = 2e-09
Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 23/198 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSL--SDQCTAEELV 347
++LP HVA +D E ++Y + + ++FA I F D + +
Sbjct: 1362 NILPDHVATYYLSD-------EHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACI 1414
Query: 348 RLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP--------EARDDHAKCCVEM 396
R+LNE+ FD L E +IK +G Y +GL E +D VE
Sbjct: 1415 RILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEF 1474
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
M + + N +RVGI +G + V+G RK +D+W N V +A+ M+S G
Sbjct: 1475 AFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGE 1534
Query: 457 AGRVHI---TKETLCCLG 471
RV + T E LC G
Sbjct: 1535 NWRVQVPENTAELLCSRG 1552
>UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebrate
adenylate cyclase 2 (Brain) (ADCY2); n=2; Danio
rerio|Rep: Novel protein similar to vertebrate adenylate
cyclase 2 (Brain) (ADCY2) - Danio rerio
Length = 793
Score = 269 bits (660), Expect = 1e-70
Identities = 131/246 (53%), Positives = 172/246 (69%), Gaps = 9/246 (3%)
Query: 290 SVLPRHVAMEMKADIASQ---PRHEQ------FHKIYIQRYENVSILFADICGFTSLSDQ 340
S+LP H+A MKA+I + P Q FH +Y+QR+ NVSIL+ADI GFT L+
Sbjct: 6 SLLPAHIARVMKAEIIQRLKGPNFSQAENTNNFHNLYVQRHTNVSILYADIVGFTRLASD 65
Query: 341 CTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM 400
C+ ELV +LNELF +FD++A ++ C+RIK+LGDCYYCVSGLP+ DHAK CV+MGLDM
Sbjct: 66 CSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAKNCVKMGLDM 125
Query: 401 IDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
+AI VRE V++NMRVG+H+G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRV
Sbjct: 126 CEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRV 185
Query: 461 HITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNV 520
HI+ TL L YKVE G+G R++YLK+H I TYL++ S + Q V
Sbjct: 186 HISSVTLEHLNGAYKVEQGNGQSRDSYLKEHGIVTYLVINPKKSEKNINSQDFGKVMNTS 245
Query: 521 SKEMRV 526
SK+ +
Sbjct: 246 SKKTSI 251
Score = 84.6 bits (200), Expect = 6e-15
Identities = 64/195 (32%), Positives = 98/195 (50%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA R+ + +Y Q Y+ V ++FA I F + E
Sbjct: 575 NVLPAHVAEHFLG------RNWKNEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLE 628
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP-----EARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL E H + + +G
Sbjct: 629 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIG 688
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A ALV ++ +N + MRVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 689 TMVEFAFALVGKLDVINKHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 748
Query: 452 ESGGVAGRVHITKET 466
ES GV G++ +T+ET
Sbjct: 749 ESTGVLGKIQVTEET 763
>UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1400
Score = 269 bits (660), Expect = 1e-70
Identities = 148/329 (44%), Positives = 197/329 (59%), Gaps = 15/329 (4%)
Query: 196 YVTYATLPVRLHEATIGG-------LALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAA 248
+V YA LP+ L I G L + +N H Q+ +A N A
Sbjct: 229 FVPYAMLPLPLKWCMIAGSVSAICHLIVTTINKFLHESDTTCIVRQMIANSLLYLAINFA 288
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQP 308
GM T + QR AF+ET +E S+LP V +++ ++ P
Sbjct: 289 GMYTKYLTDRGQRLAFIETHKAMEHKRESEKEYQRTQRLLDSILPMFVNNDIRKEMYKSP 348
Query: 309 RHEQ----FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 364
Q F K+YI +NVSILFADI GFT L+ + +A++LV++LN+LFARFD++A ++
Sbjct: 349 EQPQVDTQFKKLYIYHMDNVSILFADIKGFTELASKTSAQQLVKVLNDLFARFDKIAEDN 408
Query: 365 HCLRIKLLGDCYYCVSGLP----EARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVG 420
HCLRIKLLGDCYYCVS ++R DHA C VE GL MI AI VR V+++MR+G
Sbjct: 409 HCLRIKLLGDCYYCVSMFDSQSWKSRPDHAVCSVETGLHMIKAIKDVRVQTNVDLDMRIG 468
Query: 421 IHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGH 480
IH+G V C VLG +KW FDVWSNDV +AN+MESGGV GRVHI++ TL CL D Y+VEPG+
Sbjct: 469 IHSGSVMCGVLGEKKWHFDVWSNDVIIANHMESGGVPGRVHISEATLNCLNDTYEVEPGN 528
Query: 481 GGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
G R+++LK NI+TYLI + R K+
Sbjct: 529 GASRDSHLKMMNIKTYLIKRTEPLRPRKR 557
Score = 69.3 bits (162), Expect = 3e-10
Identities = 56/194 (28%), Positives = 89/194 (45%), Gaps = 20/194 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSL--SDQCTAEELV 347
++LP HVA ++ E+ ++Y Q +E ++FA I F D + +
Sbjct: 1043 NILPDHVASYYLSE-------ERADELYAQMHELCGVMFASIPNFKDFYSEDIENGKACI 1095
Query: 348 RLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP-------EARDDHAKC-CVEM 396
R+LNE+ + FD L E +IK +G Y S L + +D+ A C VE
Sbjct: 1096 RILNEIISDFDSLLEEERFKTVEKIKTVGATYMAASNLRSGNKTKVDEKDEEAVCDLVEF 1155
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L M + V + +RVGI +G + V+G RK +D+W N V +A+ M+S G
Sbjct: 1156 ALAMRQKLQEVNKDAFNTFQLRVGISSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGE 1215
Query: 457 AGRVHITKETLCCL 470
+V + T L
Sbjct: 1216 NWKVQVPDYTAALL 1229
>UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2;
Apocrita|Rep: ORF for hypothetical protein - Apis
mellifera (Honeybee)
Length = 998
Score = 268 bits (657), Expect = 3e-70
Identities = 144/311 (46%), Positives = 189/311 (60%), Gaps = 5/311 (1%)
Query: 193 LFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM----QLYCTIATLIACNAA 248
L Y+ +ATLP+RL + + A V + + + L + L T+ +
Sbjct: 138 LMLYLLFATLPLRLSFCVVLACSTATVYVMSVVGLSKAPAQIPVDVLVLTVTLSASAMVL 197
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQP 308
G+ ++ E QRRAFLETR +E SVLP HVA++M+ D+ +
Sbjct: 198 GLSSYSLTEFQQRRAFLETRQSLEVQLVIEEQSTEQERLLLSVLPEHVAVKMRQDLGAS- 256
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
QF KIY+ R+ENVSIL+ADI GFT++S +A ELV++LNELFARFD+L+ LR
Sbjct: 257 LDTQFKKIYMSRHENVSILYADIVGFTAISSTYSASELVKILNELFARFDQLSERFEQLR 316
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 428
IK+LGDCYYC+SG P R DHA CV MGL M++AI V++ V+MRVGIHTG V
Sbjct: 317 IKILGDCYYCISGAPIERPDHAVLCVYMGLSMVEAIKYVQQTTNSPVDMRVGIHTGAVLA 376
Query: 429 VVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYL 488
VLG R+WQFDV+S DV LAN MES G+AGRVHI+ TL L +++VEP HG R L
Sbjct: 377 GVLGQRQWQFDVYSKDVELANKMESSGMAGRVHISNATLSFLNGEFEVEPAHGEDREEAL 436
Query: 489 KDHNIETYLIV 499
+ I TY IV
Sbjct: 437 QKAGIVTYFIV 447
Score = 96.3 bits (229), Expect = 2e-18
Identities = 68/254 (26%), Positives = 117/254 (46%), Gaps = 20/254 (7%)
Query: 227 LDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXX 286
L+ S+ +C TL+ + ++ + E ++R +L R+ V
Sbjct: 696 LEPSAVPSKFCLSVTLLTVATSLVIVSRYAEKSRRMLYLRGREVVAQRERAADMKRRNGA 755
Query: 287 XXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE-- 344
++LP HVA A S+ RH +Y Q Y V +LFA + F + +
Sbjct: 756 LIYNILPPHVA----AYFLSRARHHD--DLYSQSYAEVGVLFASMPNFADFYSEESINNQ 809
Query: 345 --ELVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGLPEARDD-------HAKC 392
E +R LNE+ + FD + ++ ++IK +G Y SG+ E+ + H
Sbjct: 810 GLECLRFLNEVISDFDAILDQNKFKDIIKIKTIGSTYMAASGITESAESEDGPRWGHLST 869
Query: 393 CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
VE L++ A++ + E + +++GI+ G V V+G RK +D+W N V +A+ ME
Sbjct: 870 LVEFALELKKALSSINEQSFNHFVLKMGINHGPVTAGVIGARKPHYDIWGNTVNVASRME 929
Query: 453 SGGVAGRVHITKET 466
S G G + +T ET
Sbjct: 930 STGKVGCIQVTDET 943
>UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate
cyclase 7; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
similar to adenylate cyclase 7 - Ornithorhynchus
anatinus
Length = 816
Score = 264 bits (646), Expect = 6e-69
Identities = 126/232 (54%), Positives = 167/232 (71%), Gaps = 10/232 (4%)
Query: 290 SVLPRHVAMEMKADIASQ------PRH---EQFHKIYIQRYENVSILFADICGFTSLSDQ 340
SVLP H++M MK I + RH FH +Y++R++NV L+ADI GFT L+
Sbjct: 377 SVLPAHISMGMKLAIIERLKENNDTRHAPDNNFHSLYVKRHQNVXXLYADIVGFTRLASD 436
Query: 341 CTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM 400
C+ +ELV +LNELF +FD++A E+ C+RIK+LGDCYYCVSGLP + HA+ CV+MGLDM
Sbjct: 437 CSPKELVVMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDM 496
Query: 401 IDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
+AI V+E V+++MRVGIH+G V C V+GLRKWQ+DVWS+DV+LAN MES GV GRV
Sbjct: 497 CEAIKQVKEATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMESAGVPGRV 556
Query: 461 HITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQH 512
HIT+ TL L +Y+VE G+G R+AYLK+ NI+TYL++ D R P H
Sbjct: 557 HITEATLSHLDKEYEVEEGNGQLRDAYLKEMNIQTYLVI-DPRQRRQPLPTH 607
>UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7;
Diptera|Rep: Adenylyl cyclase isoform DAC39E -
Drosophila melanogaster (Fruit fly)
Length = 1167
Score = 259 bits (634), Expect = 2e-67
Identities = 157/395 (39%), Positives = 219/395 (55%), Gaps = 18/395 (4%)
Query: 117 IYYEKERVAHIINVIVLGLSALVFACLLACLSR---PAMNEIYLLTISYVVLVAFLLIEF 173
I +++ +IN +L L+ L LL R PA+ + + + V +LL
Sbjct: 87 IPWDQSAPTRVINCCML-LAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSIL 145
Query: 174 SFAGTSVLR---SLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLL--- 227
F +L+ S G L ++ Y TLP++L GL++ + L L
Sbjct: 146 HFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL---IFLGLSIGCITYFICLSLPVG 202
Query: 228 ----DNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXX 283
D+ QL + G+L + E Q+RAFLE + +E
Sbjct: 203 YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAE 262
Query: 284 XXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTA 343
SVLP+HVA++M+ D+ S E F KIY+ R+ENVSIL+ADI GFT++S +A
Sbjct: 263 QERLLLSVLPKHVAIKMREDLGSSSS-EAFKKIYMSRHENVSILYADIVGFTAISSTYSA 321
Query: 344 EELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDA 403
++LV++LNELFARFDRLA ++ LRIK+LGDCYYC+SG P+ R DHA CV MGL M+ A
Sbjct: 322 QDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKA 381
Query: 404 IALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
I V++ V+MRVGIHTG V +LG R+WQFDV+S DV LAN MES G AGRVHI+
Sbjct: 382 IKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHIS 441
Query: 464 KETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI 498
+TL L +++VE G R L+ ++TY I
Sbjct: 442 DKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI 476
Score = 81.4 bits (192), Expect = 6e-14
Identities = 59/195 (30%), Positives = 95/195 (48%), Gaps = 23/195 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + ++ H+ +Y Q Y V +LFA + F+ + T E
Sbjct: 871 NVLPVHVAEHFMKN--TKRSHDD---LYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLE 925
Query: 346 LVRLLNELFARFD---RLAAEHHCLRIKLLGDCYYCVSGLP---EARDD--------HAK 391
+R LNE+ + FD L ++IK +G Y SG+ R+D H
Sbjct: 926 CLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINLQRTVRNDAPITERWSHLA 985
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE L++ A+ + E + +++GI+ G + V+G RK +D+W N V +A+ M
Sbjct: 986 ILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRM 1045
Query: 452 ESGGVAGRVHITKET 466
ES G AG + +T+ET
Sbjct: 1046 ESTGKAGAIQVTEET 1060
>UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whole
genome shotgun sequence; n=3; Euteleostomi|Rep:
Chromosome undetermined SCAF14699, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1292
Score = 255 bits (625), Expect = 2e-66
Identities = 135/302 (44%), Positives = 185/302 (61%), Gaps = 36/302 (11%)
Query: 234 QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLP 293
QL + G++++ + R+AFLE R +E S+LP
Sbjct: 225 QLLANVVIYACAITVGIMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILP 284
Query: 294 RHVAMEMKADIASQPRH---EQFHKIYIQRYENV------------------------SI 326
+H+A EM D+ +P +QF+ +Y+ R+ENV SI
Sbjct: 285 KHIADEMLQDMKKEPSQKEMQQFNTMYMYRHENVRYTHRAYADPHVRATERLCACGLVSI 344
Query: 327 LFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA---------EHHCLRIKLLGDCYY 377
LFADI GFT LS C+A+ELV+LLNELFARFD+LAA ++H LRIK+LGDCYY
Sbjct: 345 LFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAVSPDSRSHSKYHQLRIKILGDCYY 404
Query: 378 CVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
C+ GLP+ R+DHA C + MGL M++AI+ VRE +V+MRVG+H+G V VLG ++WQ
Sbjct: 405 CICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQ 464
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYL 497
+DVWS DVT+AN ME+GG+ GRVHI++ TL CL ++ VEPG+GG R YL++ IETYL
Sbjct: 465 YDVWSTDVTVANKMEAGGIPGRVHISQSTLECLHGEFDVEPGNGGERCDYLRERGIETYL 524
Query: 498 IV 499
+V
Sbjct: 525 VV 526
Score = 48.0 bits (109), Expect = 7e-04
Identities = 20/49 (40%), Positives = 31/49 (63%)
Query: 414 NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHI 462
N +R+G++ G V V+G RK +D+W N V +A+ MES GV G + +
Sbjct: 1154 NFMLRIGLNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQV 1202
>UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC
4.6.1.1) (Adenylate cyclase type III) (ATP
pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III)
(AC3) (Adenylate cyclase, olfactive type).; n=1;
Takifugu rubripes|Rep: Adenylate cyclase type 3 (EC
4.6.1.1) (Adenylate cyclase type III) (ATP
pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III)
(AC3) (Adenylate cyclase, olfactive type). - Takifugu
rubripes
Length = 1159
Score = 255 bits (624), Expect = 3e-66
Identities = 159/442 (35%), Positives = 243/442 (54%), Gaps = 64/442 (14%)
Query: 117 IYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVV--LVAFLLIEFS 174
+ Y ++++A ++ V +GL+A + +L L + + ++ + Y++ ++A ++ +
Sbjct: 84 VVYTEDKLAMVV-VAAVGLAADIVLYVLCLLQKLPASPVWRGAVPYILWLMIAIHVLCYM 142
Query: 175 FAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLL------- 227
+ S G + FT+ ++ TLP+ L + L LAA++ G H+L+
Sbjct: 143 ALNYERFPHASDSVGWQAFFTFSSFLTLPLNL----VALLLLAALSCGIHVLVLGVIVTR 198
Query: 228 ---DNSSD----MQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXX 280
DN QL ++ + G++++ + R AFLE R +E
Sbjct: 199 SFEDNLQGPMLVRQLLASVMLYLCAATMGVMSYYMADRKYRMAFLEARRSLEVKVTLEEQ 258
Query: 281 XXXXXXXXXSVLPRHVAMEMKADIASQPRHE------QFHKIYIQRYENV---------- 324
S+LP+H+A EM + Q + + QF+ +Y+ R+ENV
Sbjct: 259 STQQEELLLSILPKHIADEMLQGMKDQAQQQDVQQQQQFNTMYMYRHENVRSESLFHHRD 318
Query: 325 --------------SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA-------- 362
SILFADI GFT LS C+A+ELV+LLNELFARFD+LAA
Sbjct: 319 SLVSAKRQPYCFCCSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAVSFCSQFL 378
Query: 363 -----EHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNM 417
++H LRIK+LGDCYYC+ GLP+ R+DHA C + MGL M+DAI+ VRE V+M
Sbjct: 379 YFSFIKYHQLRIKILGDCYYCICGLPDFREDHAACSIMMGLAMVDAISYVREKTKTEVDM 438
Query: 418 RVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
RVG+HTG V VLG ++WQFDVWS DVT+AN MESGG+ G+VHI++ T L ++++E
Sbjct: 439 RVGVHTGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGKVHISQTTKDSLHGEFELE 498
Query: 478 PGHGGYRNAYLKDHNIETYLIV 499
PG+GG R YL + I+TYL++
Sbjct: 499 PGNGGERCEYLLEKGIDTYLVL 520
Score = 64.9 bits (151), Expect = 5e-09
Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 40/220 (18%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYI-----QRYENVSILFADICGFTSLSDQCTAE 344
++LP HVA K + ++ R E +Y+ Q Y + ++FA I F+ + +
Sbjct: 896 NMLPEHVA---KHFLGTKMRDEVIFSVYVRLHYHQSYNEIGVMFASIPNFSDFYTEESIN 952
Query: 345 ----ELVRLLNELFARFDRL---AAEHHCL---------RIKLLGDCYYCVSGL-PEA-- 385
E +R+LNE+ + FD + H L +IK +G Y SGL PE
Sbjct: 953 NGGIECLRILNEIISDFDSVTFFCLFHQLLDREEFRSITKIKTIGSTYMAASGLTPECHT 1012
Query: 386 -------------RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
R H + L M + + + N +R+GI+ G V V+G
Sbjct: 1013 NGYDKPEDQSLFERWQHLSDLADFALSMKVTLNNLNKQSFNNFMLRIGINKGGVLAGVIG 1072
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
RK +D+W N V +A+ MES GV G + + ++ L D
Sbjct: 1073 ARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYNILKD 1112
>UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2;
Xenopus|Rep: Adenylate cyclase type VII - Xenopus laevis
(African clawed frog)
Length = 667
Score = 250 bits (612), Expect = 8e-65
Identities = 135/321 (42%), Positives = 189/321 (58%), Gaps = 17/321 (5%)
Query: 195 TYVTYATLPVRLHEATI----GGLALAAVNIGAHLLLDNSSD---MQLYCTIATLIACNA 247
T+ Y LP+ + I G++ V +L S+D QL + N
Sbjct: 25 TFSVYTMLPLGMQTCVIISIISGISHIIVISITVVLCSGSNDAIAFQLIANAVIFLCGNL 84
Query: 248 AGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS- 306
G + A R + T C+ SVLP +++M + I
Sbjct: 85 MGAYHKYHMQDASRDLYSYTVKCIRIKMKLELKKRQQESLLLSVLPVYISMGDELAIQDR 144
Query: 307 --------QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFD 358
QP + F +Y++R++NVSIL+ADI GFT L+ C+ +ELV +LNELF +FD
Sbjct: 145 LTETNDNRQPDNN-FTALYVKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFD 203
Query: 359 RLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMR 418
++A E+ C+RIK+LGDCYYCVSGLP + ++AK CV+MGLD+ ++I VRE ++NMR
Sbjct: 204 QIAKENECMRIKILGDCYYCVSGLPVSLPNNAKNCVKMGLDICESIKQVREATGADINMR 263
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
VG+H+G V C V+GLRKWQFDVWS+DV+LAN MES G+ GRVHIT+ TL + Y VE
Sbjct: 264 VGVHSGNVLCGVIGLRKWQFDVWSHDVSLANRMESAGLPGRVHITEATLKHMNGAYDVEE 323
Query: 479 GHGGYRNAYLKDHNIETYLIV 499
GHG R+ YLK+ NI+TYL++
Sbjct: 324 GHGELRDPYLKEMNIKTYLVI 344
>UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate
cyclase 7; n=1; Equus caballus|Rep: PREDICTED: similar
to adenylate cyclase 7 - Equus caballus
Length = 958
Score = 239 bits (585), Expect = 1e-61
Identities = 114/224 (50%), Positives = 150/224 (66%)
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SIL+ADI GFT L+ C+ +ELV +LNELF +FD++A + C+RIK+LGDCYYCVSGLP
Sbjct: 151 SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 210
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
+ HA+ CV+MGLDM +AI VRE V+++MRVGIH+G V C V+GLRKWQ+DVWS+D
Sbjct: 211 SLPTHARNCVKMGLDMCEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHD 270
Query: 445 VTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
V+LAN ME+ GV GRVHIT+ TL L Y+VE GHG R+ YLK+ NI TYL++ +
Sbjct: 271 VSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 330
Query: 505 RVDKKPQHSFAVNGNVSKEMRVMXXXXXXXXXXXXXVPPAAIRH 548
+ QH G+ + +MR P A + H
Sbjct: 331 QPPPPSQHLPKPKGDAALKMRASVRMTRYLESWGAARPFAHLNH 374
Score = 85.4 bits (202), Expect = 4e-15
Identities = 67/206 (32%), Positives = 103/206 (50%), Gaps = 25/206 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA D ++ + +H Q Y+ V ++FA + F +C E
Sbjct: 729 NVLPAHVAAHFIGDKLNE---DWYH----QSYDCVCVMFASVPDFKVFYTECDVNKEGLE 781
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL--PEARD--DHAKCCVEMGL 398
+RLLNE+ A FD L + +IK +G Y +GL P D D + +G+
Sbjct: 782 CLRLLNEIVADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHDNQDLERQHAHIGI 841
Query: 399 DMIDAIALVREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
+ +IAL+ ++ +N +RVGI+ G V V+G RK Q+D+W N V +A+ ME
Sbjct: 842 MVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRME 901
Query: 453 SGGVAGRVHITKETLCCL-GDDYKVE 477
S G G++ +T+ET L G Y E
Sbjct: 902 STGELGKIQVTEETSAILQGLGYSCE 927
>UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 2 -
Caenorhabditis elegans
Length = 1080
Score = 227 bits (555), Expect = 6e-58
Identities = 107/199 (53%), Positives = 142/199 (71%), Gaps = 2/199 (1%)
Query: 310 HEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRI 369
H+ FH +++Q ++NVSILFADI FT L+ Q TA++LVR LNEL+++FDR A C+RI
Sbjct: 299 HKLFHDLHVQVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRI 358
Query: 370 KLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCV 429
K LGDCYYCVSG+P R +HA CV MGL+MI+ I VR V+VNMR+G+HTG V C
Sbjct: 359 KFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGSVLCG 418
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLK 489
++GLRKWQFD+WS+DVTLAN+MES GV G VHITK T L DY + + + ++
Sbjct: 419 IMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLGDYCIVDANTD--DPHVV 476
Query: 490 DHNIETYLIVPDDTSRVDK 508
+ TY I+PD TS +++
Sbjct: 477 SYGQPTYHILPDKTSAIER 495
Score = 65.3 bits (152), Expect = 4e-09
Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 35/221 (15%)
Query: 314 HKIYIQRYENVSILFADICGFTSLSDQCTAE---ELVRLLNELFARFDRLAAE---HHCL 367
+++Y +++ENV ++FA I F + E +RLLNE+ FD+L ++
Sbjct: 838 NELYARQHENVCVMFASIPNFKDFWSEWDTNRKLECLRLLNEIVCEFDKLLSKPKFSSVE 897
Query: 368 RIKLLGDCYYCVSGLPEARDDH--------------------------AKCCVEMGLDMI 401
+IK +G Y +GL E+ D+ A +E L M
Sbjct: 898 KIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRHGNMAFRNANLMIEFALAMS 957
Query: 402 DAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVH 461
+ + N +R+G+ G + V+G +K Q+D+W N V LA+ M++ G ++H
Sbjct: 958 QILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIH 1017
Query: 462 ITKETLCCL-GDDYKVEPGHGGYRNAYLKDHNIETYLIVPD 501
T + L Y+V+ G R +K+ +ET+LI D
Sbjct: 1018 ATTDMGRVLQTGGYRVQ-SRGKIRVKGVKE-PMETFLIEVD 1056
>UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1100
Score = 215 bits (524), Expect = 3e-54
Identities = 105/187 (56%), Positives = 131/187 (70%), Gaps = 2/187 (1%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F + R ENVSILFADI GFT +S +A++LVRLLN+LF RFDRL +HC +I L
Sbjct: 279 FRPFQMHRMENVSILFADIVGFTKMSSNKSADQLVRLLNDLFGRFDRLTEYNHCEKISTL 338
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G P+ +HA CVEMGLDM++ I +V+MRVG+HTG V C ++G
Sbjct: 339 GDCYYCVAGCPKPTPNHATYCVEMGLDMLEQIKEFDNDTDNDVDMRVGVHTGTVLCGIVG 398
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHN 492
++++FDVWSNDVTLAN ME+ G+ GRVHIT+ T+ L D Y VE GHG RNA LK
Sbjct: 399 TKRFKFDVWSNDVTLANRMETAGLPGRVHITEATVGFLRDQYIVENGHGETRNAALK--G 456
Query: 493 IETYLIV 499
I TY IV
Sbjct: 457 ITTYFIV 463
Score = 72.9 bits (171), Expect = 2e-11
Identities = 89/369 (24%), Positives = 152/369 (41%), Gaps = 47/369 (12%)
Query: 125 AHIINVIVLGLS-ALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRS 183
+HI+ +++ L A VF+ + C S+ A N SY+V VA L F + L S
Sbjct: 737 SHIVGALLMCLPMATVFSNFMDC-SQLADNNARNF-FSYIVAVALL----HFCNFTQLTS 790
Query: 184 LTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATLI 243
+ T ++FT +TY L L + A + S M T A ++
Sbjct: 791 W-MKTSLAAVFT-MTYIIL-----------LQFDDFCVRAAPMTTEGSRMAKEVTAALVL 837
Query: 244 ACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKAD 303
+L Q E+ RR F + + S+ P+HV+ +K
Sbjct: 838 LWLLVALLNRQ-LEMGVRRNFSGDAEAAKVKKKSQVHKQQADWLLLSLFPKHVSEALKTS 896
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLA 361
H Y Y N ++FA I F+ ++ +E +R+LNEL FD L
Sbjct: 897 -----DH------YSMNYNNAGVMFASIVNFSDFYEENFEGGKECIRVLNELVGDFDELL 945
Query: 362 AEHHCLRIKLL----GDCYYCVSGLPEARD--------DHAKCCVEMGLDMIDAIALVRE 409
+ ++ + G + +GL + + +H K VE L+M + + E
Sbjct: 946 DNIEYMEVEKIKTVNGSTFMAGAGLNQEDNIRREIHPYEHLKQLVEFALEMFNVVDRFNE 1005
Query: 410 -VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLC 468
++ +R+G + G V V+G K +D+W + V LA+ M+S GV ++ +++ T
Sbjct: 1006 HMLGFKFKLRIGFNAGPVTAGVIGTTKLLYDIWGDTVNLASRMDSTGVPEKIQVSESTKE 1065
Query: 469 CLGDDYKVE 477
L D + E
Sbjct: 1066 MLNDFFIFE 1074
>UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,
isoform A; n=2; Endopterygota|Rep: PREDICTED: similar to
CG9210-PA, isoform A - Tribolium castaneum
Length = 1370
Score = 207 bits (506), Expect = 5e-52
Identities = 131/339 (38%), Positives = 178/339 (52%), Gaps = 18/339 (5%)
Query: 157 LLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEA-TIGGLA 215
++++S+VVLV SF TS + S C + Y +P++L+ + TIG L
Sbjct: 159 VISLSFVVLVPMKTDPLSFPITSDI-SPVGHFSICIEILMLIYTLIPLKLYMSITIGFLY 217
Query: 216 LAAVNIGAHLLLDNSSDMQLYCTIATL--IACNAAGMLTHQPRELAQRRAFLETRDCVEA 273
AA + L N S T+ L + G+ + R F++ +
Sbjct: 218 SAAFET-LTISLQNQSLEASTITVRLLSHFCIHVIGLHILIMTNVRMRNTFMKVGQSLLV 276
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQ-------------FHKIYIQR 320
S++P VA + ++ + R +Q F + R
Sbjct: 277 RRQLESEKKLKENMIHSLMPSSVAEWLLSEEETFTRSDQRNSDPETNDIRSLFRPFNMNR 336
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
ENVSILFADI GFT ++ + +AEELV +LN LF RFD L H+C +I LGDCYYCVS
Sbjct: 337 MENVSILFADIVGFTKMASKKSAEELVEILNNLFQRFDHLCKFHNCEKISTLGDCYYCVS 396
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
G PE R DHAKCCVEMGL MI AI + VNMRVG+HTG V C ++G R+++FDV
Sbjct: 397 GCPEPRHDHAKCCVEMGLSMIQAIKQFDQEKNEGVNMRVGVHTGTVLCGIVGTRRFKFDV 456
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
WSNDVTLAN MES G G VH++++T L D Y +E G
Sbjct: 457 WSNDVTLANRMESTGKPGMVHVSEKTCEFLQDMYLLEEG 495
Score = 81.0 bits (191), Expect = 8e-14
Identities = 62/222 (27%), Positives = 105/222 (47%), Gaps = 27/222 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++V I+FA I F + D+ +E +
Sbjct: 1152 NIVPEHVAEQLKKNAK-----------YSENFKDVGIIFASIVNFNEMYDESYLGGKEYL 1200
Query: 348 RLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEAR-------DDHAKCCVEMG 397
R+LNEL A FD L +IK +G + SGL ++H ++
Sbjct: 1201 RVLNELIADFDELLDRPEFASVEKIKTIGSTFMAASGLNSTTRRNQKDPNEHLYALMDFA 1260
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L+M + I R+++ N+ +R+G + G V V+G K +D+W + V +A+ M+S GV
Sbjct: 1261 LEMQNVITDFNRDLLEFNLILRIGYNFGEVTAAVIGNTKLYYDIWGDAVNIASRMDSTGV 1320
Query: 457 AGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI 498
G + I + L L Y P Y KD N+ YL+
Sbjct: 1321 NGCIQIGENCLQVLETRYVFRPRGSVYVKG--KD-NMSVYLL 1359
>UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF8089, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 821
Score = 207 bits (506), Expect = 5e-52
Identities = 116/262 (44%), Positives = 166/262 (63%), Gaps = 42/262 (16%)
Query: 290 SVLPRHVAMEMKADIA---SQPRHEQ--------FHKIYIQRYENVSILFADICGFTSLS 338
SVLPR++AME+K+++ S+P ++ FH +YI+++++VSIL+ADI GFT L+
Sbjct: 8 SVLPRYIAMELKSEVIKRLSKPESKEKNESNRHNFHSLYIRQHKDVSILYADIVGFTKLA 67
Query: 339 DQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAK------- 391
+ +ELV +LN+LF RFD +A ++ CLRIK+LGDCYYCVSGLP+ +HA+
Sbjct: 68 SSLSPQELVAVLNKLFGRFDDIAKKNGCLRIKILGDCYYCVSGLPDPIPNHARNCVQMGL 127
Query: 392 --C----CVE------MGL----------DMIDAIALVREVMAVNVNMRVGIHTGRVHCV 429
C CV +GL D + +RE V ++MRVG+HTG V C
Sbjct: 128 DMCTAIRCVSFMVLSSLGLLFLLSWSRNNDFPCGCSKLREATGVEISMRVGVHTGNVLCG 187
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLK 489
V+GL+KWQ+DVWS+DVTLAN+MESGG+ GRVHIT+ETL L Y+VE G R+ L
Sbjct: 188 VIGLQKWQYDVWSHDVTLANHMESGGLPGRVHITEETLQHLNGAYQVEESDGASRDPLL- 246
Query: 490 DHNIETYLIVPDDTSRVDKKPQ 511
H +TYL++ + ++P+
Sbjct: 247 -HGRKTYLVIDPHKPDISRRPK 267
Score = 77.4 bits (182), Expect = 1e-12
Identities = 54/169 (31%), Positives = 88/169 (52%), Gaps = 18/169 (10%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELFARFDRLAAE---HHCLR 368
+Y Q Y+ V ++FA + F + +A E +R LNE+ + FD L ++ +
Sbjct: 617 LYSQSYDCVCVMFASVPQFKEFYSESSANNDGLECLRFLNEIISDFDELLSKPKFSSVEK 676
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCCVEMGLD----MID-AIALVREVMAVNVN------M 417
IK +G Y +GL A VEM M++ AIAL+ ++ +N + +
Sbjct: 677 IKTIGSTYMAAAGLTLAPVGDENKKVEMSYSHVRAMVEFAIALMSKLEFINKHSFNIFKL 736
Query: 418 RVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
R+GI+ G V V+G K Q+D+W N V +A+ MES GV ++ +T+ET
Sbjct: 737 RIGINHGPVIAGVIGAHKPQYDIWGNSVNVASRMESTGVLDKIQVTEET 785
>UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD
CG5712-PA; n=1; Apis mellifera|Rep: PREDICTED: similar
to ACXD CG5712-PA - Apis mellifera
Length = 1051
Score = 206 bits (504), Expect = 9e-52
Identities = 117/322 (36%), Positives = 168/322 (52%), Gaps = 21/322 (6%)
Query: 199 YATLPV--RLHEATIGGLALAAVNIGAHLLL-DNSSDMQLYCTIATL--IACNAAGMLTH 253
Y LP+ LH +G + L+ NS D T+ + N G+
Sbjct: 92 YVFLPLTKNLHALILGITTTTCYLVALSLITYRNSFDFSTKIITDTIYFVCVNGLGLYFR 151
Query: 254 QPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS------- 306
E+ RR+FL+ R CVE+ S+LP+H+A ++K +
Sbjct: 152 FMNEIVTRRSFLDHRKCVESTLRLNYEKDQEEQLTRSILPQHIAAKIKKEFRDIFKFLEE 211
Query: 307 ---QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
P+ F + ++ + NVSIL+AD+ F+ L+ +LV LN+LF FD +
Sbjct: 212 HKKPPKPSSFSDLCVETHNNVSILYADVVNFSGLTVTLPVRKLVETLNDLFGSFDEASER 271
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMI----DAIALVREVMAVNVNMRV 419
H+ LRIK LGDCYYCVSG+P HAK CV++GLDMI D A VR V+VNMR+
Sbjct: 272 HNVLRIKFLGDCYYCVSGVPTPNSQHAKSCVDLGLDMIKIIKDVRAKVRRESGVDVNMRI 331
Query: 420 GIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL-GDDYKVEP 478
G+H+G + +LG+ KWQ+DVWS DV +AN ME G G+VHIT++TL + ++Y P
Sbjct: 332 GVHSGNIISGILGVSKWQYDVWSRDVVIANKMEQTGKPGKVHITQQTLDLVDANEYDCVP 391
Query: 479 GHGGYRNAYLKDHNIETYLIVP 500
+ LK + I +YLI P
Sbjct: 392 -VDSLNDEVLKKYGIRSYLITP 412
Score = 68.5 bits (160), Expect = 4e-10
Identities = 63/240 (26%), Positives = 113/240 (47%), Gaps = 34/240 (14%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP HVA E ++ +E +H + + NV+++FA + S+ + T + +
Sbjct: 816 NILPEHVA-EFYLNMNRTVENEPYH----EAHSNVAVMFASLTD-VSIDESNT----LAV 865
Query: 350 LNELFARFDRLAAEHHCLRI---KLLGDCYYCVSGLPEAR--------------DDHAKC 392
LNE+ FD+L E + RI K+ G Y GL +R D+ K
Sbjct: 866 LNEIICEFDKLLFEPYFNRIEKIKIAGTTYMAACGLEASRRDSMRSPENEENITDNVVKV 925
Query: 393 CVEMGLDMI---DAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLAN 449
+ ++MI D + + + +R+GI G V V+G +K +D+W + V +A+
Sbjct: 926 MAQFAVEMIAVLDKLKMRTFYTSKPYRLRIGISHGEVTAGVVGAQKPLYDIWGDAVNMAS 985
Query: 450 YMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHN-IETYLIVPDDTSRVDK 508
M++ GV G++ IT ET L + ++ G + Y+K + TY I DD ++ +
Sbjct: 986 RMDTTGVPGKIQITAETAAVL-EQQGIKCHLRG--DTYVKPKGLVTTYFIGIDDNRQLQR 1042
>UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to adenylate cyclase - Nasonia vitripennis
Length = 1092
Score = 202 bits (494), Expect = 1e-50
Identities = 133/398 (33%), Positives = 206/398 (51%), Gaps = 27/398 (6%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTV 186
++N ++ + AL F L + + + I +++++ L I + S SL+
Sbjct: 98 VVNALLFPIIALSFRTELVA-KKSYLPVYFSCLIIFLLVIGDLSIAIYYTSKSSNESLSF 156
Query: 187 STGACSLFTYVTYATLPV--RLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATLI- 243
+ V Y LP+ LH A I G+ + I + LL+ ++ + I++ +
Sbjct: 157 RPVYATHTLLVCYIFLPLASNLH-AFILGVTASFCYIASLLLVTYRNEPDIGTKISSDVI 215
Query: 244 --AC-NAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEM 300
C N G+ E+ RR+FL+ R CVE+ S+LP H A ++
Sbjct: 216 YHTCVNCLGLYFRFMNEIMTRRSFLDRRKCVESTLRLNYEKDQEEQLTRSILPPHFAAKI 275
Query: 301 KAD------------IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVR 348
K + I F +Y++ +ENVSIL+AD+ F+ L+ ++LV
Sbjct: 276 KKNFRDILTFLPVLIIKFISDCALFRDLYVETHENVSILYADVVNFSGLTVTLPVKKLVE 335
Query: 349 LLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAI---- 404
LN+LF FD + H+ LRIK LGDCYYCVSG+P HAK CV++GLDMI+ I
Sbjct: 336 TLNDLFGSFDEASERHNVLRIKFLGDCYYCVSGVPIPNSQHAKSCVDLGLDMINIINAVR 395
Query: 405 ALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITK 464
A V+ V+VNMR+G+H+G++ +LG KWQ+DVWS DV +AN ME G AG+VH+T+
Sbjct: 396 ARVQRESGVDVNMRIGVHSGKIISGILGTNKWQYDVWSRDVIIANKMEQTGEAGKVHVTQ 455
Query: 465 ETLCCLG-DDYKVEPGHGGYRNAYLKDHNI-ETYLIVP 500
+TL L + Y P +A L+ + I ++YLI P
Sbjct: 456 QTLDLLDVNSYNCSP-VTKLNDAVLEKYGIFQSYLISP 492
Score = 60.5 bits (140), Expect = 1e-07
Identities = 49/203 (24%), Positives = 91/203 (44%), Gaps = 25/203 (12%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+L R++ E AD H +Y + ++NV+++FA + T LS ++
Sbjct: 854 LLLRNILPEHVADFYLNMDRADEHTLYHEAHDNVAVMFATL---TDLS--IDESNILVDF 908
Query: 351 NELFARFDRLAAEHHCL----RIKLLGDCYYCVSGLPEARDDHA---------------- 390
N++ FD+L E + + +IKL G Y GL +R
Sbjct: 909 NQIICHFDKLLFESNYVCRIEKIKLAGTTYMAACGLEVSRRHSTQSSSSTSESDVKYNVV 968
Query: 391 KCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANY 450
+ V+ +M+ + ++ +R+GI G V V+G +K +D+W + V +A+
Sbjct: 969 RVMVQFAAEMMYVLESIKMQTTRPYKLRIGIAHGEVTAGVVGAQKPLYDIWGDAVNMASR 1028
Query: 451 MESGGVAGRVHITKETLCCLGDD 473
M++ G G++ +T ET L D+
Sbjct: 1029 MDTTGEVGKIQVTTETAEVLKDE 1051
>UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate
cyclase type ix; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to adenylate cyclase type ix -
Nasonia vitripennis
Length = 1314
Score = 200 bits (487), Expect = 1e-49
Identities = 97/179 (54%), Positives = 121/179 (67%), Gaps = 2/179 (1%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F + ++VSILFADI GFT +S TAEELV +LN+LF RFD L H C +I L
Sbjct: 351 FRPFNMHSMDDVSILFADIVGFTKMSSNKTAEELVGILNDLFERFDDLCELHGCEKISTL 410
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCVSG PE R DHAKCCVEMGL MI+AI VNMRVG+HTG V C ++G
Sbjct: 411 GDCYYCVSGCPEPRPDHAKCCVEMGLAMIEAIKQFDIERREGVNMRVGVHTGTVLCGIVG 470
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGH--GGYRNAYLK 489
++++FDVWSNDVTLAN +ES G GRVH++++TL L + Y E G G + ++K
Sbjct: 471 TKRFKFDVWSNDVTLANKLESTGKPGRVHLSEKTLSFLEEQYLTEDGEPVNGIKTYFIK 529
Score = 80.6 bits (190), Expect = 1e-13
Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 13/175 (7%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLAAEH---HCLRIKL 371
Y Q ++ V I+FA I F L D+ +E +R+LNEL FD L + + +IK
Sbjct: 1118 YSQNHKAVGIIFATIVNFNELYDESYLGGKEYLRVLNELIGDFDELLEKQDYSNVEKIKT 1177
Query: 372 LGDCYYCVSGL-PEARD--DHAKCCVEMGLDMIDAIALV-----REVMAVNVNMRVGIHT 423
+G + SGL P+ R +H + LD A+ V ++++ + +RVG +
Sbjct: 1178 IGSTFMAASGLNPQVRQQSEHEHTHIYQLLDFAMAMHKVIYDFNQDLLGFKLILRVGFNF 1237
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
G V V+G K +D+W + V +A+ M+S GVAG + L + + Y EP
Sbjct: 1238 GDVTAGVIGSSKLYYDIWGDAVNIASRMDSTGVAGEIQFASNCLDVIAERYNYEP 1292
>UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl
cyclase type IX; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to adenylyl cyclase type IX -
Strongylocentrotus purpuratus
Length = 1073
Score = 199 bits (486), Expect = 1e-49
Identities = 116/293 (39%), Positives = 161/293 (54%), Gaps = 14/293 (4%)
Query: 223 AHLLLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXX 282
A L D + ++ + + + GM ++ R FL+ + V A
Sbjct: 100 ASLQPDEVNATHVFTKLFLHLCIHMMGMHIFFMSQVRNRSTFLKVVETVVAQNLHKREKQ 159
Query: 283 XXXXXXXSVLPRHVAMEMKADIASQP-------RHEQ----FHKIYIQRYENVSILFADI 331
S++P +A E+ S P R + F Y+ R ENVSIL+ADI
Sbjct: 160 IKEATIQSLMPDTIAKELLKGRESNPEVRPHIGRRQSSEPIFRPFYMNRMENVSILYADI 219
Query: 332 CGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAK 391
GFT +S +AE LV LLN LF RFD L H+C +I LGDCYYCVSG P R+DHA+
Sbjct: 220 AGFTKMSANKSAEVLVGLLNNLFGRFDLLCRRHNCEKICTLGDCYYCVSGCPVKREDHAQ 279
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
CCVEMGL MI+AI VNMRVGIHTG V C ++G R+++FDVWSNDVT+AN M
Sbjct: 280 CCVEMGLSMIEAIKDFCHETGEKVNMRVGIHTGTVLCGIVGNRRFKFDVWSNDVTIANKM 339
Query: 452 ESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
E+ G G+VH++ E++ L + Y ++ G+ ++A L ++TY I + S
Sbjct: 340 EASGQPGKVHVSAESIKFLKERYVLDEGNAD-KHALL--IGMKTYFIAGRNAS 389
Score = 70.5 bits (165), Expect = 1e-10
Identities = 45/176 (25%), Positives = 86/176 (48%), Gaps = 15/176 (8%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLAAE---HHCLRIKL 371
+ Q ++NV+++F I F ++ +E +R+L+EL + FD L + +IK
Sbjct: 868 FSQNHDNVAVIFCSIVNFNDFYEEAYEGGKECIRVLHELISDFDNLLNDPKYKEVEKIKT 927
Query: 372 LGDCYYCVSGL-PEARDDHAKCCVE---------MGLDMIDAIALVREVMAVNVNMRVGI 421
+G Y GL P + ++ + + M L + L + A N +R+G
Sbjct: 928 IGSTYMAACGLRPSEKPNNVQTLITLMDFSDEMMMQLQKFNDDVLSMTIGAFNFILRIGY 987
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
+ G++ V+G K +D+W + V +A+ M+S G+ G V +T+ ++ L Y+ E
Sbjct: 988 NHGKLTSGVIGTTKLLYDIWGDTVNVASRMDSTGMPGHVQVTEHSMTVLEPYYEFE 1043
>UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:
ENSANGP00000019838 - Anopheles gambiae str. PEST
Length = 1536
Score = 198 bits (484), Expect = 2e-49
Identities = 95/178 (53%), Positives = 121/178 (67%), Gaps = 2/178 (1%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F ++ R ENVSILFADI GFT +S TAE+LV +LN+LF RFD L + C +I L
Sbjct: 341 FRPFHMNRMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCLVNGCEKISTL 400
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCVSG PE R DHA CCVEMGL MI++I + + MRVG+HTG V C ++G
Sbjct: 401 GDCYYCVSGCPEPRPDHAICCVEMGLGMIESIRVFDAQRNEGIKMRVGVHTGTVLCGIVG 460
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGH--GGYRNAYL 488
++ +FDVWSNDVTLAN MES G +VH+++ET LGD Y +E G G+R ++
Sbjct: 461 TKRVKFDVWSNDVTLANRMESSGKPDQVHVSEETCGFLGDSYIIEEGEEVDGHRTYFV 518
Score = 103 bits (248), Expect = 1e-20
Identities = 72/220 (32%), Positives = 115/220 (52%), Gaps = 24/220 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P+HVA ++K Y + + N+ I+FA I F + D+ +E +
Sbjct: 1314 NIIPKHVAEQLKNTAK-----------YSENHHNIGIIFASIVNFNEMYDESYLGGKEYL 1362
Query: 348 RLLNELFARFDRLAA--EHHCL-RIKLLGDCYYCVSGL-PEARDD---HAKCCVEMGLDM 400
R+LNEL FD L A E C+ +IK +G + SGL P +R + H ++ L M
Sbjct: 1363 RVLNELIGDFDELLARPEFRCVEKIKTIGSTFMAASGLDPSSRGETYEHLYTLLDFALAM 1422
Query: 401 IDAI-ALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGR 459
+ + R+++ N+ MRVG + G V V+G K +D+W + V +A+ M+S GVAGR
Sbjct: 1423 QQVVESFNRDLLEFNLIMRVGYNFGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGVAGR 1482
Query: 460 VHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
V + + + LG+ Y EP Y KDH +E YL+V
Sbjct: 1483 VQVGADCIPVLGERYDFEPRGKVYVKG--KDH-MEVYLLV 1519
>UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29;
Euteleostomi|Rep: Adenylate cyclase type 9 - Homo
sapiens (Human)
Length = 1353
Score = 198 bits (484), Expect = 2e-49
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 67.7 bits (158), Expect = 8e-10
Identities = 62/247 (25%), Positives = 118/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + ++ N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1255
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1256 LSISPDI 1262
>UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4;
Sophophora|Rep: Adenylyl cyclase isoform DAC9 -
Drosophila melanogaster (Fruit fly)
Length = 1708
Score = 195 bits (476), Expect = 2e-48
Identities = 97/175 (55%), Positives = 116/175 (66%)
Query: 305 ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 364
AS F ++ ENVSILFADI GFT +S TAE+LV +LN+LF RFD L +
Sbjct: 335 ASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLS 394
Query: 365 HCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 424
C +I LGDCYYCVSG PE R DHA CCVEMGL MIDA+ V MRVG+HTG
Sbjct: 395 GCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTG 454
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
V C ++G R+ +FDVWSNDV+LAN MES G +VHI++ET LGD Y +E G
Sbjct: 455 TVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEG 509
Score = 93.1 bits (221), Expect = 2e-17
Identities = 64/210 (30%), Positives = 108/210 (51%), Gaps = 18/210 (8%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLAA--EHHCL-RIKL 371
Y + + N++I+FA I F + D+ +E +R+LNEL FD L + E + +IK
Sbjct: 1375 YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKT 1434
Query: 372 LGDCYYCVSGL-PEAR---DDHAKCCVEMGLDMIDAI-ALVREVMAVNVNMRVGIHTGRV 426
+G + SGL P R D+H +E + M + + A ++++ N+ +R+G++ G V
Sbjct: 1435 IGSTFMAASGLDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDV 1494
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNA 486
V+G K +D+W + V +A+ M+S G+ R+ + K+ L L + Y+ EP Y
Sbjct: 1495 TAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNRYEFEPRGSVYVKG 1554
Query: 487 YLKDHNIETYLIV-----PDDTSRVDKKPQ 511
KDH +E +L P D DK Q
Sbjct: 1555 --KDH-MEVFLYTTRRDNPLDDDEADKVEQ 1581
>UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p -
Drosophila melanogaster (Fruit fly)
Length = 1162
Score = 194 bits (474), Expect = 4e-48
Identities = 113/340 (33%), Positives = 178/340 (52%), Gaps = 31/340 (9%)
Query: 190 ACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTI--ATLIAC-N 246
A +L+ + +P L +G I ++ D Q++ + A ++C N
Sbjct: 162 AYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVN 221
Query: 247 AAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIA- 305
G+ R++A R FL+ R VE S+LP +A ++ D+
Sbjct: 222 LLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKN 281
Query: 306 ----SQPRHEQFHKI----------------------YIQRYENVSILFADICGFTSLSD 339
S+ +H+Q ++ +I+ +E+V++L+AD+ +T L+
Sbjct: 282 RIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTT 341
Query: 340 QCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLD 399
++LV L++LF RFD + E++ LRIK LGDCYYCV+GL DHAKCCV++GL
Sbjct: 342 TLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLR 401
Query: 400 MIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGR 459
MI I VRE +N++MR+G+H+G V V+G KWQFD+WS DV +AN +E+ G GR
Sbjct: 402 MIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGR 461
Query: 460 VHITKETLCCLGDDYKVEPGHGGYR-NAYLKDHNIETYLI 498
VH++++TL L +Y E G R + L+ H I T+LI
Sbjct: 462 VHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI 501
Score = 54.0 bits (124), Expect = 1e-05
Identities = 28/83 (33%), Positives = 49/83 (59%), Gaps = 4/83 (4%)
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+R+GI GR V+G+ K +D+W N V +A+ M+S GV G++ +T+ T L ++ +
Sbjct: 1063 LRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKL-REFNI 1121
Query: 477 EPGHGGYRNAYLKDH-NIETYLI 498
+ + G ++K NI TY+I
Sbjct: 1122 QCNYRGM--TFVKGRGNIPTYII 1142
>UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1154
Score = 194 bits (473), Expect = 5e-48
Identities = 92/189 (48%), Positives = 128/189 (67%), Gaps = 1/189 (0%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F K+Y+Q++ NV+IL+AD+ +T ++ Q + LV +L+ELF +FD A E + LRIK L
Sbjct: 321 FSKLYVQKHTNVTILYADVVNYTFITTQLPVKSLVDVLHELFVKFDEAAKEFNVLRIKFL 380
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCVSG+P HAK CV++GL MI I VR +N++MR+GIH+G + V+G
Sbjct: 381 GDCYYCVSGVPIKNKHHAKSCVDLGLRMIKDIRDVRMSRDLNIDMRIGIHSGSIISGVIG 440
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYR-NAYLKDH 491
KWQ+D+WS DV +AN MES G AG+VH+T +TL L +Y E G + + L H
Sbjct: 441 ACKWQYDIWSRDVIIANKMESTGEAGKVHVTMQTLELLDGEYIYEDGTDKAKSDPVLVKH 500
Query: 492 NIETYLIVP 500
NI+T+LIVP
Sbjct: 501 NIQTFLIVP 509
Score = 51.2 bits (117), Expect = 7e-05
Identities = 21/50 (42%), Positives = 34/50 (68%)
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+RVGI G+V V+G K +D+W N V +A+ M+S G+ G++ +TKE+
Sbjct: 1054 LRVGISNGKVMAGVVGSSKPLYDIWGNAVNMASRMDSTGIPGKIQVTKES 1103
>UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 18
SCAF14786, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 576
Score = 187 bits (455), Expect = 8e-46
Identities = 95/180 (52%), Positives = 117/180 (65%), Gaps = 1/180 (0%)
Query: 293 PRHVAMEMKADIASQPRHEQ-FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLN 351
P+H K S PR + F ++R E VSILFADI GFT +S +A LV LLN
Sbjct: 373 PKHTHNNHKCKKTSIPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAPALVGLLN 432
Query: 352 ELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVM 411
+LF RFDRL C +I LGDCYYCV+G PE DHA CCVEMGL MI AI +
Sbjct: 433 DLFGRFDRLCELTGCEKISTLGDCYYCVAGCPEPSADHAYCCVEMGLGMIQAIEQFCQET 492
Query: 412 AVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLG 471
V+MRVG+HTG V C +LG+++++FDVWSNDV LAN ME GVAG+VH+++ T LG
Sbjct: 493 RETVSMRVGVHTGTVLCGILGMKRFKFDVWSNDVNLANLMEQLGVAGKVHLSEATAQFLG 552
>UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein acy-1 - Caenorhabditis elegans
Length = 1253
Score = 184 bits (448), Expect = 6e-45
Identities = 93/172 (54%), Positives = 115/172 (66%)
Query: 308 PRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 367
P + +F + NVSILFADI GFT +S +A+ELV LLN+LF RFD L
Sbjct: 302 PEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLE 361
Query: 368 RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVH 427
+I LGDCYYCV+G PE DDHA VEMGLDMI AI VNMRVGIHTG+V
Sbjct: 362 KISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVM 421
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
C ++G ++++FDV+SNDVTLAN MES GVAGRVH+++ T L Y++E G
Sbjct: 422 CGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEG 473
Score = 73.7 bits (173), Expect = 1e-11
Identities = 56/196 (28%), Positives = 94/196 (47%), Gaps = 15/196 (7%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLAAEH---HCLRIKL 371
Y + +E V +LFA I + + ++ E +R+LNE+ FD L H +IK
Sbjct: 1041 YSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKT 1100
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAV-NVNM-------RVGIHT 423
+G Y SGL R + E M+D V+ V++V N ++ ++G++
Sbjct: 1101 IGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGLNI 1160
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V V+G K +D+W + V +A+ M S GV R+ +++ T L D Y+ E +
Sbjct: 1161 GPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEFE--FRDH 1218
Query: 484 RNAYLKDHNIETYLIV 499
D ++TYL+V
Sbjct: 1219 IEVKGIDGGMDTYLLV 1234
>UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 8 SCAF9864, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 879
Score = 178 bits (434), Expect = 3e-43
Identities = 82/142 (57%), Positives = 104/142 (73%), Gaps = 2/142 (1%)
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
G YYCVSGLPE+ +HAK CV+MGLDM +AI VR+ V++NMRVG+H+G V C V+G
Sbjct: 277 GGSYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIG 336
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHN 492
L+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT TL L YKVE G G R+ YLK+H
Sbjct: 337 LQKWQYDVWSHDVTLANHMEAGGVPGRVHITSVTLEHLNGAYKVEDGDGQERDPYLKEHG 396
Query: 493 IETYLIVPDDTSRVDKKPQHSF 514
+ TYL++ R + PQH +
Sbjct: 397 VITYLVINPKVER--RSPQHHY 416
Score = 87.4 bits (207), Expect = 9e-16
Identities = 66/196 (33%), Positives = 102/196 (52%), Gaps = 25/196 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA A R+ + +Y Q Y+ V ++FA I F + E
Sbjct: 646 NVLPAHVAEHFLA------RNWKNEDLYHQSYDLVCVMFASIPDFKEFYTESDVNKEGLE 699
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PE-ARDDHAKCCVEM 396
+RLLNE+ A FD L ++ +IK +G Y +GL PE A +H + + +
Sbjct: 700 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNASPGPEHASQEHDRQYMHI 759
Query: 397 GLDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANY 450
G + A ALV ++ +N + +RVGI+ G V V+G +K Q+D+W N V +A+
Sbjct: 760 GTMVEFAFALVGKLDVINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASR 819
Query: 451 MESGGVAGRVHITKET 466
MES GV G++ +T+ET
Sbjct: 820 MESTGVLGKIQVTEET 835
>UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep:
CG32305-PA - Drosophila melanogaster (Fruit fly)
Length = 1102
Score = 168 bits (408), Expect = 4e-40
Identities = 97/317 (30%), Positives = 156/317 (49%), Gaps = 17/317 (5%)
Query: 199 YATLPVRLHEAT---IGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIACNAAGML 251
Y TLP+ ++ + + G+ ++ + IG + +D + +A+ L N
Sbjct: 124 YMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSF 183
Query: 252 THQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQ---- 307
R+ RRA L V S+LPR + ++ +I S+
Sbjct: 184 FTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQ 243
Query: 308 -----PRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
P K++++ Y NVSIL AD+ +T L+ A +LV +L++LF FD A
Sbjct: 244 DKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAAN 303
Query: 363 EHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIH 422
+ +RIK LGD Y CV+G+P HA CCV+ L+MI V +++N+R+G+H
Sbjct: 304 RNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVH 363
Query: 423 TGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGG 482
+G V ++G KWQFD+WS DV + N +ES G+ G VH+++ TL L + Y G
Sbjct: 364 SGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEA 423
Query: 483 YRN-AYLKDHNIETYLI 498
+N L+ I T+L+
Sbjct: 424 AKNDPILQQAGIRTFLV 440
Score = 45.2 bits (102), Expect = 0.005
Identities = 27/106 (25%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
++++GI G V V+GL K +D+W + V +A+ M S G+ + +T+ T L +
Sbjct: 939 SLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL-RQFN 997
Query: 476 VEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNVS 521
+ + G+ + TYL+V D Q S ++ + S
Sbjct: 998 IRCNYRGHTEV-KGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDSKS 1042
>UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13;
Sophophora|Rep: CG5983-PA, isoform A - Drosophila
melanogaster (Fruit fly)
Length = 1130
Score = 155 bits (375), Expect = 4e-36
Identities = 76/182 (41%), Positives = 113/182 (62%), Gaps = 2/182 (1%)
Query: 318 IQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYY 377
IQ + +VSIL+AD+ +T L+ T LV++L++L+ RFD A+ RIK LGDCYY
Sbjct: 309 IQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYY 368
Query: 378 CVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
CV+GL DHAKCCV +G+ MI I VR ++++MR+G+H+G + ++G K Q
Sbjct: 369 CVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQ 428
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD-DYKVEPGHGGYRNAYLKDHNIETY 496
FD+W DV +AN++ES G G VH++ TL L DY + G ++ + + I TY
Sbjct: 429 FDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTY 487
Query: 497 LI 498
L+
Sbjct: 488 LL 489
Score = 46.0 bits (104), Expect = 0.003
Identities = 30/110 (27%), Positives = 59/110 (53%), Gaps = 8/110 (7%)
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
+GI +G + V+G + +D+W N V +A+ MES G+ G + +T+E+ L ++ ++
Sbjct: 1008 IGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL-QEFDIKC 1066
Query: 479 GHGGYRNAYLKDH-NIETYLIVPDDTSRVDKKPQHSFAVNGNVSKEMRVM 527
+ G ++K +I TY + D+ + K + VN ++S+ VM
Sbjct: 1067 IYRGM--TFVKGRGDIPTYFVGIDE----NLKFMSAKLVNRSLSRRFSVM 1110
Score = 35.1 bits (77), Expect = 5.0
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 10/73 (13%)
Query: 314 HKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA---EHHCL-RI 369
H++Y + Y VS++FA + F +R+LN++ +FDRL E++ + +I
Sbjct: 859 HELYYENYRMVSVMFAMLINFPMNLPS------LRVLNDIITQFDRLLTAYREYYVVEKI 912
Query: 370 KLLGDCYYCVSGL 382
K++G Y GL
Sbjct: 913 KVVGCTYMAACGL 925
>UniRef50_Q9JK77 Cluster: Adenylyl cyclase 3; n=7; Euteleostomi|Rep:
Adenylyl cyclase 3 - Mus musculus (Mouse)
Length = 110
Score = 153 bits (370), Expect = 2e-35
Identities = 70/110 (63%), Positives = 88/110 (80%)
Query: 326 ILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEA 385
ILFADI GFT LS C+A+ELV+LLNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+
Sbjct: 1 ILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDY 60
Query: 386 RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
R+DHA C + MGL M++AI+ VRE V+MRVG+HTG V VLG ++
Sbjct: 61 REDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKR 110
>UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila
melanogaster|Rep: CG32301-PA - Drosophila melanogaster
(Fruit fly)
Length = 1076
Score = 153 bits (370), Expect = 2e-35
Identities = 100/316 (31%), Positives = 150/316 (47%), Gaps = 13/316 (4%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM----QLYCTIATLIACNAAGML 251
Y+ + V+ A GLA++ G L+D S + +L A L N M
Sbjct: 146 YLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMF 205
Query: 252 THQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHE 311
+ +E R L V S++P +A ++ IAS +
Sbjct: 206 LSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEED 265
Query: 312 Q-----FHK---IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
F K ++++ + VSIL AD+ FT L+ +LV +L+ELF FD A
Sbjct: 266 PSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANH 325
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
+ RIK LGD Y CV+G+P HA CV LDMI+ V + +++R+G+H+
Sbjct: 326 NRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHS 385
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G + ++GL KWQFD+WS DV + N +ES G+ G VHI+ TL L + Y E G
Sbjct: 386 GEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTA 445
Query: 484 R-NAYLKDHNIETYLI 498
+ + L+ N+ TYLI
Sbjct: 446 KLDPLLQRSNLSTYLI 461
Score = 46.0 bits (104), Expect = 0.003
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++++GI G V V+GL K +D+W + V +A+ M S GV +H+T+ T L D
Sbjct: 961 SLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRD 1017
>UniRef50_Q5DTS7 Cluster: MKIAA4004 protein; n=2; Murinae|Rep:
MKIAA4004 protein - Mus musculus (Mouse)
Length = 422
Score = 151 bits (367), Expect = 4e-35
Identities = 91/232 (39%), Positives = 127/232 (54%), Gaps = 18/232 (7%)
Query: 196 YVTYATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIAT---LIAC-NAA 248
+ YA LP+ + +A G+ + ++ G +L S L +A L C N
Sbjct: 161 FTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWQPESQRALLPQLAANAVLFLCGNVV 220
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIA--- 305
G E A R F E + + S+LP ++A EMKA+I
Sbjct: 221 GAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARL 280
Query: 306 -----SQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDR 359
S+P + FH +Y++R++ VS+L+ADI GFT L+ +C+ +ELV +LNELF +FD+
Sbjct: 281 QAGQRSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQ 340
Query: 360 LAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAI--ALVRE 409
+A EH C+RIK+LGDCYYCVSGLP + DHA CV MGLDM AI ALV E
Sbjct: 341 IAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRSALVCE 392
>UniRef50_Q5BXY8 Cluster: SJCHGC07735 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07735 protein - Schistosoma
japonicum (Blood fluke)
Length = 228
Score = 142 bits (344), Expect = 2e-32
Identities = 70/128 (54%), Positives = 87/128 (67%)
Query: 352 ELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVM 411
+LF RFDRL C +I LGDCYYCVSG P DHA+ VEMG M AI E
Sbjct: 1 DLFGRFDRLCELVGCEKIATLGDCYYCVSGCPNPVVDHAERTVEMGRAMCLAIQQFDEDH 60
Query: 412 AVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLG 471
+ VNMRVG+HTG+V C ++G ++++FDVWSNDVTLAN MES G AG+VHI++ TL +
Sbjct: 61 SEEVNMRVGVHTGKVICGIVGTKRFKFDVWSNDVTLANEMESSGEAGKVHISEATLSFVK 120
Query: 472 DDYKVEPG 479
D Y+V G
Sbjct: 121 DIYEVSEG 128
>UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1;
Beggiatoa sp. PS|Rep: Adenylate/guanylate cyclase -
Beggiatoa sp. PS
Length = 430
Score = 138 bits (333), Expect = 5e-31
Identities = 67/166 (40%), Positives = 101/166 (60%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R +Q +I + NV++LFADI GFT LS++ +A++LV LLNE+F+ FD+L +H +
Sbjct: 239 RLKQEEQIIADHFTNVTVLFADIVGFTQLSERLSAKKLVELLNEIFSTFDKLVEKHGLEK 298
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 428
IK +GD Y V GLP +D EM LDM +A+A ++ +R+GIH G V
Sbjct: 299 IKTIGDAYMVVGGLPVPIEDSVTPIAEMALDMQEALAQFNRRYHYDLKIRIGIHNGAVVA 358
Query: 429 VVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
V+GL+K+ +D+W + V A+ MES G+AG + ++ L D Y
Sbjct: 359 GVIGLKKFAYDLWGDTVNTASRMESHGIAGCIQVSNRVYDALEDKY 404
>UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC
7120|Rep: Adenylate cyclase - Anabaena sp. (strain PCC
7120)
Length = 472
Score = 137 bits (332), Expect = 6e-31
Identities = 69/188 (36%), Positives = 110/188 (58%), Gaps = 3/188 (1%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP+ +A +K SQP + + + + +++FADI GFT LS + + LV L
Sbjct: 261 NILPQAIAERLKQ---SQPSPQTSQMMIADGFSDATVMFADIVGFTDLSGRIPPQRLVDL 317
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN++F+RFD LA ++ +IK +GD Y V GLP R DHA MGLD++DAIA
Sbjct: 318 LNQIFSRFDLLAESYNLEKIKTIGDAYMVVGGLPNPRPDHAIAIAHMGLDILDAIAQFNL 377
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+R+GI++G V V+G++K+ +D+W + V +A+ MES G R+H++ +
Sbjct: 378 DTGEQFKIRIGINSGPVVAGVIGIKKFIYDLWGDTVNIASRMESHGTPNRIHVSAASHEL 437
Query: 470 LGDDYKVE 477
L D + E
Sbjct: 438 LKDSFLFE 445
>UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; n=3;
Bacteria|Rep: Extracellular ligand-binding receptor -
Lyngbya sp. PCC 8106
Length = 1301
Score = 137 bits (332), Expect = 6e-31
Identities = 75/188 (39%), Positives = 107/188 (56%), Gaps = 10/188 (5%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LPR +A +K + H I +R+++ +I+FADI FT S Q ELV L
Sbjct: 1102 NILPRSIAERLK---------QAPHSI-AERFDHATIMFADIVDFTGFSSQIAPTELVDL 1151
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNE+F+ FD A +H +IK +GD Y V GLP +DDH K EM LDM I +
Sbjct: 1152 LNEIFSAFDAFAQKHDLEKIKTIGDSYMVVGGLPTPKDDHVKAIAEMALDMQREICRFQR 1211
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+ +R+GI+TG V V+G RK+ +D+W + V +A+ MES G AG++ +TK T
Sbjct: 1212 HDGLPFRLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVASRMESHGEAGKIQVTKATYDL 1271
Query: 470 LGDDYKVE 477
L D Y E
Sbjct: 1272 LKDQYIFE 1279
>UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4;
Burkholderiaceae|Rep: Adenylate/guanylate cyclase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 395
Score = 136 bits (330), Expect = 1e-30
Identities = 74/188 (39%), Positives = 105/188 (55%), Gaps = 2/188 (1%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP +A +K + F ++ R+ +VS+LFADI FT S E+LV +
Sbjct: 183 NMLPYPIAERLKVHLDDIAG--SFPEVIADRFADVSVLFADIVDFTGFSAGMRPEQLVEM 240
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNE+F FD +A +IK +GD Y +GLP DHA M LDMIDA+A
Sbjct: 241 LNEIFTGFDTIADHCGLEKIKTIGDAYMAAAGLPVPAADHATRAAHMALDMIDALARFNA 300
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
N+ +R+GI++G V V+G RK+ +D+W V LA+ MES GVAGRV +T T
Sbjct: 301 ARHCNLKLRIGINSGEVVAGVIGKRKFIYDLWGAAVNLASRMESQGVAGRVQVTDATRVM 360
Query: 470 LGDDYKVE 477
LG+ + E
Sbjct: 361 LGEAFVFE 368
>UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 545
Score = 136 bits (330), Expect = 1e-30
Identities = 63/157 (40%), Positives = 100/157 (63%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+E V++LFADI GFT LS + + ELV LLNE+F+ FD++ +++ +IK +GD Y V
Sbjct: 367 FEEVTVLFADIAGFTQLSAKISPTELVNLLNEIFSEFDQITTQNNLEKIKTIGDAYLVVG 426
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
GLP R DHA+ ++ L+M + + + N+ +R+GI+TG V V+G +K+ +D+
Sbjct: 427 GLPNPRSDHAEAIAKLALEMQNKLIEFNQKHDHNLQLRIGINTGPVVAGVIGAKKFIYDL 486
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
W + V +A+ MES G+ G + +T+ T L D YK E
Sbjct: 487 WGDTVNIASRMESHGIIGEIQVTEATYQRLQDKYKFE 523
>UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 358
Score = 135 bits (327), Expect = 3e-30
Identities = 72/182 (39%), Positives = 105/182 (57%), Gaps = 3/182 (1%)
Query: 299 EMKADIASQPRHEQFHK---IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFA 355
++ +I Q EQ K + R+E +ILFADI FT L+ Q + ELV LLN++F+
Sbjct: 145 QLLLNILPQAIAEQLKKQPGLIADRFEQATILFADITDFTGLASQISPTELVSLLNQIFS 204
Query: 356 RFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNV 415
FDRLA H +IK +GD Y V GLP+ R DHA+ +M LDM I + +
Sbjct: 205 SFDRLAERHGLEKIKTIGDAYMVVGGLPKPRTDHAEAIADMALDMQQEIYRFKREDNKIL 264
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
N+R+GI+TG V V+GL+K+ +D+W + V +A+ MES G G + ++ T L Y
Sbjct: 265 NIRIGINTGPVVAGVIGLKKFSYDLWGDAVNIASRMESHGKIGEIQVSSSTYELLKHKYV 324
Query: 476 VE 477
+E
Sbjct: 325 LE 326
>UniRef50_UPI00005A96A3 Cluster: PREDICTED: similar to adenylate
cyclase 1; n=1; Canis lupus familiaris|Rep: PREDICTED:
similar to adenylate cyclase 1 - Canis familiaris
Length = 546
Score = 134 bits (323), Expect = 8e-30
Identities = 60/93 (64%), Positives = 72/93 (77%)
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
V E V++N+RVG+HT RV C VLGLRKWQ+DVWSNDVTLAN ME G+ +VHIT+ T
Sbjct: 154 VAEATEVDLNVRVGLHTSRVLCGVLGLRKWQYDVWSNDVTLANVMEVAGLPRKVHITRTT 213
Query: 467 LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
L CL DY+VE GHG RN++LK HNIET+ IV
Sbjct: 214 LACLNGDYEVEEGHGHERNSFLKAHNIETFFIV 246
>UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 491
Score = 133 bits (321), Expect = 1e-29
Identities = 80/256 (31%), Positives = 126/256 (49%), Gaps = 10/256 (3%)
Query: 219 VNIGAHLLLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXX 278
+N H+ L +S M +I + A Q E ++R F T + A
Sbjct: 213 INRQVHVGLRGTSIMLTGLSILAISALTLVIGRLRQTSEELEQRVFERTTELRRANIELS 272
Query: 279 XXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLS 338
S+LP+ +A +K + + +ILFADI GFT+LS
Sbjct: 273 NEQKKSEELLLSILPQSIANRLKNGEVN----------IADCFAEATILFADIVGFTTLS 322
Query: 339 DQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGL 398
+ E++VR+LNE+F+ FDRL + +IK +GD Y V GLP R DHA EM L
Sbjct: 323 KEVKPEKVVRILNEIFSDFDRLCDRYKLEKIKTIGDAYMVVGGLPNPRKDHAAAIAEMAL 382
Query: 399 DMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAG 458
DM+D + V + +R+GI++G V ++G +K+ +D+W + V A+ MES G+AG
Sbjct: 383 DMLDDLNQFNAKNNVKLEIRIGINSGPVIAGIIGTKKFIYDLWGDAVNTASRMESHGIAG 442
Query: 459 RVHITKETLCCLGDDY 474
+ +T+ T L ++
Sbjct: 443 EIQLTETTFDYLQKEF 458
>UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 442
Score = 132 bits (319), Expect = 2e-29
Identities = 65/157 (41%), Positives = 95/157 (60%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+ + +LF DI GFT LS + ELV+LL ++F+RFD LA +H+ +IK +GD Y VS
Sbjct: 263 FTDAGVLFGDIVGFTELSGKMPPAELVQLLGQIFSRFDHLADKHNLEKIKTIGDAYMVVS 322
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
GLP ++D+A+ +M LDM I MR+GI G V V+GLRK+ +D+
Sbjct: 323 GLPIPKEDYAERIADMALDMQKTILEFNAETERKFQMRIGIAIGPVVAGVIGLRKFIYDL 382
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
W + V +A+ MES G+A + +T+ T L DDY +E
Sbjct: 383 WGDTVNIASRMESHGIANEIQVTETTYHALKDDYSLE 419
>UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, family
3 (some proteins contain HAMP domain); n=1; Nostoc
punctiforme PCC 73102|Rep: COG2114: Adenylate cyclase,
family 3 (some proteins contain HAMP domain) - Nostoc
punctiforme PCC 73102
Length = 433
Score = 130 bits (314), Expect = 1e-28
Identities = 66/154 (42%), Positives = 92/154 (59%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+ V++LFADI GFT LS + + ELV LLN +F FD+LA H +IK +GD Y V+
Sbjct: 252 FMEVTVLFADIVGFTELSARTSPTELVELLNTIFCLFDQLAELHKVEKIKTIGDAYMAVA 311
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
GLP DHA M LDM +AIA+ ++R+GI TG V V+GL+K+ +D+
Sbjct: 312 GLPNQSKDHALAIANMALDMQNAIAIFNAENNQLFSIRIGISTGPVVAGVIGLKKFAYDL 371
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
W + V A+ MES G+AG + + + T L D Y
Sbjct: 372 WGDTVNTASRMESHGIAGNIQVCEATYQLLKDKY 405
>UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1;
Ralstonia eutropha H16|Rep: Putative regulatory protein
- Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428
/ Stanier 337)(Cupriavidus necator (strain ATCC 17699 /
H16 / DSM 428 / Stanier337))
Length = 412
Score = 130 bits (314), Expect = 1e-28
Identities = 65/157 (41%), Positives = 93/157 (59%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+ V++LFADI FT S + E+LV +LNE+F FD +A +IK +GD Y +
Sbjct: 229 FPEVTVLFADIVAFTRFSAGMSPEQLVAILNEIFTEFDTIAEVRGLEKIKTIGDAYMAAA 288
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
GLPE DHA M L+M DA+ + N+ MR+GI++G V V+G RK+ +D+
Sbjct: 289 GLPEPAPDHAVRAAHMALNMSDALMHFNQHTGFNLQMRIGINSGAVVAGVIGKRKFIYDL 348
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
W V +A+ MES GVAGRV +T T LG+ ++ E
Sbjct: 349 WGAAVNIASRMESHGVAGRVQVTDATRRLLGESFQFE 385
>UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 657
Score = 127 bits (306), Expect = 9e-28
Identities = 63/175 (36%), Positives = 99/175 (56%), Gaps = 3/175 (1%)
Query: 303 DIASQPRHEQFHK---IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDR 359
+I QP E+ K I +++VS+LFAD+ GFT S + T +++ +LN +F+ FD+
Sbjct: 458 NILPQPIAERLQKQPGIIADYFQDVSVLFADLVGFTDFSSEATPAQILEILNSIFSHFDQ 517
Query: 360 LAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRV 419
L+ + +IK +GD Y V GLP DH +M LDM + + N +R+
Sbjct: 518 LSQHYGLEKIKTIGDAYMVVGGLPLYHRDHLHAIAKMALDMQTNLTQFNQQTGNNFLLRI 577
Query: 420 GIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
GIH G V V+GL K+ +D+W + V +A+ MES GV+G++ +T E L D +
Sbjct: 578 GIHAGPVVAGVIGLSKFSYDLWGDTVNVASRMESNGVSGQIQVTSEVYERLKDQF 632
>UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular
organisms|Rep: Guanylyl cyclase - Dictyostelium
discoideum (Slime mold)
Length = 1486
Score = 126 bits (305), Expect = 1e-27
Identities = 68/217 (31%), Positives = 118/217 (54%), Gaps = 8/217 (3%)
Query: 296 VAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFA 355
VA + ADI + + ++ + ++NV+I +DI GFT ++ + + +LV LN++++
Sbjct: 1144 VAEILPADIVKSMKSGR--QLIVDEFKNVTIFLSDIVGFTEMAARMSPRQLVETLNQIYS 1201
Query: 356 RFDRLAAEHHCLRIKLLGDCYYCVSGLPEA-RDDHAKCCVEMGLDMIDAIALVREVMAVN 414
FD +A E L+I +GD Y+CVSG P+ + DHA M + M+++I +R V +
Sbjct: 1202 TFDEIAQEFGVLKIATIGDAYFCVSGCPDKDQTDHAFRVANMAIKMLESIKSIRTVDNIP 1261
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
+ MR+GIHTG V V+G++ + +W V + MES A +H++++T L Y
Sbjct: 1262 IRMRIGIHTGPVIAGVVGIKMIHYQLWGESVQITQQMESTSRADMIHVSEDTFNILKSKY 1321
Query: 475 KVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQ 511
E G +K I+TY ++ T D +P+
Sbjct: 1322 LFEERPDG----IIKKRKIKTYFLLRALTEN-DPQPE 1353
Score = 84.2 bits (199), Expect = 8e-15
Identities = 42/148 (28%), Positives = 84/148 (56%), Gaps = 5/148 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + Y+ V++LF +I F +L ++ ++ +++ LLNE++ FDRL + +++ +G+
Sbjct: 386 LIVDSYDPVTVLFCEIVNFNALVEKMSSTQVINLLNEVYNSFDRLTDVYGVTKVEHIGNV 445
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y V G PE DHA+ M L M ++++R V V R+G+HTG V ++G +K
Sbjct: 446 YMVVGGCPELCPDHAQRVAHMSLGM---LSVIRRFGIVQV--RIGMHTGPVVGGIIGKKK 500
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHIT 463
+ ++ + + ++ M S GR+ ++
Sbjct: 501 LSWHLFGDTINTSSRMASHSSIGRIQVS 528
>UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=1;
Methylobacterium sp. 4-46|Rep: Response regulator
receiver protein - Methylobacterium sp. 4-46
Length = 531
Score = 124 bits (298), Expect = 8e-27
Identities = 60/159 (37%), Positives = 90/159 (56%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
R+ V++LF D+ GFT L+ + T V LL+ +F+ FDR A +IK +GD Y
Sbjct: 347 RFAQVTVLFCDLVGFTPLAGRLTPGGTVDLLSRVFSAFDRSVARRGVEKIKTIGDAYMAA 406
Query: 380 SGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFD 439
G+PE DHA+ + DM+ + V + V + +RVGIH+G V+G ++ +D
Sbjct: 407 GGIPETTPDHARRIALLAFDMMADVEEVGRALGVELAVRVGIHSGEAVAGVIGQSRFAYD 466
Query: 440 VWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
VW + V +A MES G AGR+HI++ T LG D+ P
Sbjct: 467 VWGDSVNIAARMESHGQAGRIHISESTRRALGGDFFCTP 505
>UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 1 beta -
Limax marginatus
Length = 444
Score = 124 bits (298), Expect = 8e-27
Identities = 67/218 (30%), Positives = 122/218 (55%), Gaps = 10/218 (4%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
+A+ H Q K+ ++++ V++LF+DI FT+++ C+ ++V +LNE++ RFD ++
Sbjct: 40 VATALTHGQ--KVEAEKFDQVTVLFSDIVTFTNIASACSPMDIVNMLNEMYQRFDERTSQ 97
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIH 422
H+ +++ +GD Y VSG+PE +HA+ + LDM++ LVR + + +RVG+H
Sbjct: 98 HNVYKVETIGDAYMIVSGVPERTTNHAQPVADFALDMVEDAGLVRSPATGLPLQIRVGVH 157
Query: 423 TGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITK---ETLCCLGDDYK---- 475
TG V V+G++ ++ ++ + V A+ MES G GR+H++ LC G +K
Sbjct: 158 TGPVVAGVVGVKMPRYCLFGDTVNTASRMESHGAPGRIHMSPTAYRALCSSGYVFKQRGQ 217
Query: 476 VEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
+E G + Y +++ L P D K +HS
Sbjct: 218 MEVKGKGVMSTYFLCGHLDRMLTEPQDEFTALKVHRHS 255
>UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3;
Oscillatoriales|Rep: Adenylate cyclase - Spirulina
platensis
Length = 671
Score = 122 bits (295), Expect = 2e-26
Identities = 69/180 (38%), Positives = 108/180 (60%), Gaps = 13/180 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
+VLP+ +A ++KA+ K E V+ILFADI GFT LS + ELV L
Sbjct: 463 NVLPKPIADQLKAN----------KKAIASAIEEVTILFADIVGFTPLSARMDPIELVSL 512
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNE+F+ FD LA +H +IK +GD Y V GLP +++HA+ +M L+M A+ +
Sbjct: 513 LNEMFSIFDNLADKHKLEKIKTIGDAYMVVGGLPLPQNNHAEAIADMALEMQAAMKQFQG 572
Query: 410 ---VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ + + +R+GI+TG V V+G++K+ +D+W + V +A+ MES G G + +T+ET
Sbjct: 573 SYLMGSESFQIRIGINTGAVVAGVIGIKKFIYDLWGDAVNIASRMESSGTPGSIQVTEET 632
>UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 833
Score = 122 bits (295), Expect = 2e-26
Identities = 62/159 (38%), Positives = 95/159 (59%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
++Y+ VSILFAD+ FT+LS++ T +LV+LLNE+F+ FD+LA +IK +GD Y
Sbjct: 653 EKYDEVSILFADLVDFTALSERLTPIQLVKLLNEIFSTFDQLAEGLDLEKIKTIGDAYMM 712
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
+GLP R+DHA+ +M L M + + +R+GIHTG V V+G K+ +
Sbjct: 713 AAGLPLPREDHAETIADMALSMQLVVDHFPFDYGETLQIRIGIHTGTVVAGVIGTHKFIY 772
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
D+W + V +A MES G G++ +T L ++Y E
Sbjct: 773 DLWGDTVNIAYRMESSGKPGKIQVTAAVYERLKNEYIFE 811
>UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15;
Mycobacterium|Rep: Adenylate cyclase - Mycobacterium
bovis
Length = 443
Score = 122 bits (295), Expect = 2e-26
Identities = 66/186 (35%), Positives = 103/186 (55%), Gaps = 2/186 (1%)
Query: 296 VAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFA 355
+A + A IA + + + I +Y+ S+LFADI GFT + +LVR L+ L++
Sbjct: 223 LANMLPASIAERLKEPE-RNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYS 281
Query: 356 RFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNV 415
FD L +H +IK+ GD Y VSG+P R DH + + LDM + A +++ V
Sbjct: 282 AFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPV 341
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
+RVG+ TG V V+G R++ +DVW + V +A+ MES G++ + E L DD+
Sbjct: 342 PLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFV 401
Query: 476 V-EPGH 480
+ E GH
Sbjct: 402 LRERGH 407
>UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1;
Microscilla marina ATCC 23134|Rep: Heat-stable
enterotoxin receptor - Microscilla marina ATCC 23134
Length = 711
Score = 122 bits (293), Expect = 3e-26
Identities = 71/213 (33%), Positives = 118/213 (55%), Gaps = 17/213 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP A E+K + P+H Y+ VS+LF D GFT L+++ T +E++
Sbjct: 508 NILPEQTATELKEKGYATPQH----------YDLVSVLFTDFKGFTKLAEKITPQEVIEE 557
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIA---L 406
LN F FD++ +H+ +IK +GD Y G+P A + V+ GL+M +
Sbjct: 558 LNYCFTAFDKILEKHNLEKIKTIGDAYMAAGGIPLANQTNPVDAVKAGLEMQAFMVHWKK 617
Query: 407 VREVMAVNV-NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+E + V +R+GIHTG + V+G +K+ +D+W + V LA+ MESGG AG+V+I+ +
Sbjct: 618 DKEAQGLPVWELRLGIHTGEIIAGVVGKKKFAYDIWGDTVNLASRMESGGEAGKVNISGD 677
Query: 466 TLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI 498
T + D ++ E + G NA K N++ Y +
Sbjct: 678 TYALIKDHFQCE--YRGKINAKNKG-NVDMYFV 707
>UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:
Adenylate cyclase - Leptospira interrogans
Length = 492
Score = 120 bits (288), Expect = 1e-25
Identities = 56/141 (39%), Positives = 88/141 (62%), Gaps = 1/141 (0%)
Query: 325 SILFADICGFTSLSDQC-TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
++LFADI GF+ LS Q T +LV +LN++F FD +A+++ +IK +GDCY G+P
Sbjct: 317 TVLFADIVGFSKLSTQIPTPNQLVEILNQIFTCFDDIASKYQLEKIKTIGDCYMMAGGIP 376
Query: 384 EARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSN 443
A +DH + G+DMI + +++ N+R+GIHTG V V+G K+ +D+W +
Sbjct: 377 IATEDHVEKIALAGIDMIQGLKDLQKSWKYEFNIRIGIHTGDVVAGVIGKNKFVYDLWGD 436
Query: 444 DVTLANYMESGGVAGRVHITK 464
V A+ MES G GR+H ++
Sbjct: 437 SVNTASRMESHGEPGRIHCSE 457
>UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Herpetosiphon aurantiacus ATCC 23779|Rep:
Adenylyl cyclase class-3/4/guanylyl cyclase -
Herpetosiphon aurantiacus ATCC 23779
Length = 355
Score = 120 bits (288), Expect = 1e-25
Identities = 65/180 (36%), Positives = 100/180 (55%), Gaps = 4/180 (2%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
IA Q + +Q + + + +VS+LFADI GFT LS A+ELV LN LF+RFD++ +
Sbjct: 158 IADQLKDQQAN--IAEYFSSVSVLFADIVGFTELSGHINAKELVAWLNRLFSRFDQMTLD 215
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
+IK +GD Y +GLP A+ DHA+ M+ I + + MR+GIH+
Sbjct: 216 VGLEKIKTIGDAYMVAAGLPIAQPDHAERLALFATSMLAEIEQITMPNGKPLQMRIGIHS 275
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD--DYKVEPGHG 481
G V V+G K+ +D+W + V +A+ MES + ++ ET L D + ++P HG
Sbjct: 276 GPVVAGVIGTIKFSYDLWGDTVNIASRMESSAHPNTIQVSAETYALLQDHEHFSLQPRHG 335
>UniRef50_UPI0000E4A5D0 Cluster: PREDICTED: similar to adenylyl
cyclase type V, partial; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to adenylyl cyclase
type V, partial - Strongylocentrotus purpuratus
Length = 424
Score = 118 bits (285), Expect = 3e-25
Identities = 75/196 (38%), Positives = 100/196 (51%), Gaps = 5/196 (2%)
Query: 133 LGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACS 192
LGL +VF L +R + L + YVVL I + RS T
Sbjct: 230 LGLFEIVFIVLGVLCNRNSFTPRQLRFVCYVVLALLGAIVIIDVLDTEPRSATAGVWTTV 289
Query: 193 LFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM----QLYCTIATLIACNAA 248
Y+ Y LPVR+ A + GL + +++ A + NS D Q+ + + N A
Sbjct: 290 FIIYLIYTLLPVRMRLAVMFGLVYSILHV-ACAVGRNSQDSFLWKQVLANLFIFLGANLA 348
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQP 308
G+ TH P E+AQR+AFLETR C+EA SVLPRHVAMEMKADIA++
Sbjct: 349 GIFTHYPTEVAQRQAFLETRRCIEARLITQRENQQQERLLLSVLPRHVAMEMKADIANKR 408
Query: 309 RHEQFHKIYIQRYENV 324
QFHKIYIQR+++V
Sbjct: 409 EDIQFHKIYIQRHQDV 424
>UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulator;
n=3; Bacteria|Rep: Two-component hybrid sensor and
regulator - Bradyrhizobium japonicum
Length = 527
Score = 118 bits (284), Expect = 4e-25
Identities = 57/159 (35%), Positives = 91/159 (57%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
R+E VS+LFAD+ GFT S + T +V LN LF+ FD LA E +IK +GD Y V
Sbjct: 349 RFEGVSVLFADLVGFTEHSSRVTPAAMVEYLNRLFSEFDALARELGVEKIKTIGDAYMAV 408
Query: 380 SGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFD 439
+GLP+ D +M L MID + V + +R+GIH+G V ++G ++ +D
Sbjct: 409 AGLPDPNPDAIAAIAKMALGMIDRLGRVNSHFGWPLQIRIGIHSGPVVAGIIGAHRFIYD 468
Query: 440 VWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
VW + V +A+ +E+ + R+H++++ L + +EP
Sbjct: 469 VWGDTVNVASRLEAYSLPNRIHVSRDIARHLVGRFALEP 507
>UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2;
Sinorhizobium|Rep: Putative regulatory protein -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 520
Score = 118 bits (283), Expect = 5e-25
Identities = 62/169 (36%), Positives = 96/169 (56%), Gaps = 1/169 (0%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R + +I R++ VSILFADI GF+ ++ TA +LVR L+ +F RFD L +H +
Sbjct: 334 RLQDGEEIIADRFDEVSILFADIVGFSPIAASLTASDLVRRLDRMFRRFDLLTEQHRVEK 393
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 428
IK +GD Y G+PE DHA V +G M+ ++ + E +R+GIHTG V
Sbjct: 394 IKTIGDAYMAACGIPEPAPDHADRIVALGKSMLRSLQDM-EAGPDRFRVRIGIHTGPVVA 452
Query: 429 VVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
++G ++ +DVW V +A+ +ES GVA + I++ T L + +E
Sbjct: 453 GLIGRLRFVYDVWGETVNIASRLESQGVADVIQISEATRRALRGPWTLE 501
>UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1;
Jannaschia sp. CCS1|Rep: Adenylate/guanylate cyclase -
Jannaschia sp. (strain CCS1)
Length = 417
Score = 117 bits (282), Expect = 7e-25
Identities = 67/189 (35%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
S+LPR +A +KA+ P H NV+I+FADI FT LS + +V L
Sbjct: 217 SLLPREIAGRLKAE----P-----HTTIADSLPNVAIVFADIANFTPLSARLDPRRVVDL 267
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN +F FD LA H +IK +GD Y +G+P + + A +M LDM++
Sbjct: 268 LNGVFTEFDGLADRHQLEKIKTIGDAYMVAAGMPNSCGNPAHRAADMALDMLEVARATSV 327
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+ +R+G+H G V V+G RK +DVW V A+ ME+ GR+ IT
Sbjct: 328 ALPEGFEIRIGLHVGPVVAGVIGNRKLFYDVWGETVNTASRMETYSAPGRILITPAARAQ 387
Query: 470 LGDDYKVEP 478
LG+D+ EP
Sbjct: 388 LGEDFMFEP 396
>UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1;
Limax marginatus|Rep: Soluble guanylyl cyclase 2 beta -
Limax marginatus
Length = 406
Score = 116 bits (280), Expect = 1e-24
Identities = 58/173 (33%), Positives = 103/173 (59%), Gaps = 4/173 (2%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
+A+Q ++ Q + ++++ V++LF+DI FT ++ C+ ++V++LN+++ RFD+ E
Sbjct: 43 VANQLKNGQ--AVEAEKFDQVTVLFSDIVTFTDIASACSPMDIVKMLNDMYNRFDKKTNE 100
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIH 422
H +++ +GD Y V G+PE D HA+ LDM++ A V + +RVGIH
Sbjct: 101 HGVYKVETIGDAYMVVCGVPEKTDTHAQPVASFALDMVEQAACVMSPATGKPLQIRVGIH 160
Query: 423 TGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL-GDDY 474
TG V V+G+R ++ ++ + V A+ MES G+ GR+H++ T L G Y
Sbjct: 161 TGPVVAGVVGVRMPRYCLFGDTVNTASRMESHGMPGRIHLSPSTFQALEGQGY 213
>UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Tetrahymena|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Tetrahymena thermophila SB210
Length = 2997
Score = 115 bits (276), Expect = 4e-24
Identities = 70/205 (34%), Positives = 107/205 (52%), Gaps = 4/205 (1%)
Query: 318 IQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYY 377
I ++NV+IL+ADI GFT S E +V +L ELF +FD+ E+ ++ +GDCY
Sbjct: 2786 IDNFDNVTILYADIAGFTKYSASVRPENVVFMLRELFTKFDQKCQENDVFKLYTIGDCYV 2845
Query: 378 CVSGLPEARDDHAK---CCVEMGLDMIDAIALVREVMAVN-VNMRVGIHTGRVHCVVLGL 433
+ + D+AK ++MG MID I VR V+ + + MR+GIHTG + V+G
Sbjct: 2846 VMGLVNIENRDYAKEALNVIKMGFCMIDIIQQVRAVVNFDELEMRIGIHTGSIIGGVVGT 2905
Query: 434 RKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNI 493
++D++ DV +AN MES G +GRV I++ T + D Y+ E R + +N
Sbjct: 2906 GVVRYDIYGPDVVIANKMESNGESGRVMISEATYNLVNDGYQQEYEFEQARLIKIPAYNR 2965
Query: 494 ETYLIVPDDTSRVDKKPQHSFAVNG 518
E + R D + NG
Sbjct: 2966 EIQGYLVKKIQREDSNYSFKYLQNG 2990
Score = 59.7 bits (138), Expect = 2e-07
Identities = 47/161 (29%), Positives = 77/161 (47%), Gaps = 13/161 (8%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCY 376
Y + V+ILF DIC F S+ +Q + +++LL++LF +D + + +I+ +G Y
Sbjct: 2193 YQEDQGEVAILFCDICDFDSVIEQ-EKKNVIKLLDKLFRIYDESCSNYGLQKIETVGKTY 2251
Query: 377 YCVSGLP-----------EARDDHAKCCVEMGLDMID-AIALVREVMAVNVNMRVGIHTG 424
GL R V M DM + A + + +N+++GIH G
Sbjct: 2252 MAAGGLKGIPPVKKYLINNERIHPVTNSVLMAYDMYENAKKITYGNKSDKLNVKIGIHYG 2311
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
RV V+G K QF + + V +A+ + S G A V I+ E
Sbjct: 2312 RVMAGVIGGHKPQFSLIGDTVNMASRVCSTGAADSVTISAE 2352
>UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|Rep:
Cya1625 - Mycobacterium smegmatis
Length = 369
Score = 114 bits (275), Expect = 5e-24
Identities = 59/148 (39%), Positives = 87/148 (58%), Gaps = 2/148 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL-RIKLLGD 374
I RY++ SILFADI G+T + + +LVR L+ L+ D L E HCL ++K GD
Sbjct: 163 IIADRYDDASILFADIAGYTKRASETAPCDLVRFLDTLYTDLDAL-VEQHCLEKVKTSGD 221
Query: 375 CYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
Y V G+PE R DHA+ + LDM A+A + + V +R+G+ G V V+G R
Sbjct: 222 SYMVVGGIPEPRTDHAEALAALALDMAAAVADLTDPEGRRVPLRIGLAAGPVVAGVVGAR 281
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHI 462
++ +DVW + V +A+ MES V GR+ +
Sbjct: 282 RFFYDVWGDAVNVASRMESTDVEGRIQV 309
>UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1;
Methylobacillus flagellatus KT|Rep: Adenylate/guanylate
cyclase - Methylobacillus flagellatus (strain KT / ATCC
51484 / DSM 6875)
Length = 426
Score = 114 bits (275), Expect = 5e-24
Identities = 56/161 (34%), Positives = 95/161 (59%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V+ILFADI FT +S T +V LLN +F+RFD+LAA++ +IK +GD Y ++
Sbjct: 239 HDAVTILFADIVNFTQISAGMTPAAVVDLLNHVFSRFDQLAAQYGVEKIKTIGDAYMVIA 298
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
G P R DHA +M L++ + V + + + MR+G+++G V ++G ++ +D+
Sbjct: 299 GAPSPRTDHAHVMADMALEVPALLDKVSREIGMPLAMRIGMNSGAVVAGIIGNTRFSYDL 358
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHG 481
W + V +A+ ME+ G+ + ++ T L DY EP G
Sbjct: 359 WGDAVNIASRMETTGLPNEIQVSAATYELLKADYCFEPRCG 399
>UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_172, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2514
Score = 114 bits (275), Expect = 5e-24
Identities = 71/183 (38%), Positives = 101/183 (55%), Gaps = 14/183 (7%)
Query: 308 PRH--EQFHKIYIQR------YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDR 359
P H EQF K QR YENV++LFADI GFT S + + E++V +L LF FD+
Sbjct: 2289 PSHMLEQFLKFQQQRAVLKDSYENVTLLFADIAGFTEYSSKVSPEQVVFMLRNLFTEFDK 2348
Query: 360 LAAEHHCLRIKLLGDCYYCVSGLPEARD----DHAKCCVEMGLDMIDAIALVRE-VMAVN 414
E ++ +GDC Y V G+ +A+D AK VE+G +MI I VR+ +
Sbjct: 2349 CCQEKSVYKLYTIGDC-YVVMGMLDAKDRNIAQEAKNTVELGFEMISIIKRVRDHINFQG 2407
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
++MR+GIHTG + VLG ++D++ DV +AN MES G G + ++ T L Y
Sbjct: 2408 LDMRIGIHTGNIIGGVLGTEIVRYDIYGPDVLIANKMESKGERGNLQVSSTTKEILEQHY 2467
Query: 475 KVE 477
E
Sbjct: 2468 PEE 2470
Score = 55.6 bits (128), Expect = 3e-06
Identities = 35/146 (23%), Positives = 73/146 (50%), Gaps = 5/146 (3%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+ILF DIC F + + E ++ LL+ LF ++D L +++ +I+ +G Y +GL
Sbjct: 1745 VAILFCDICQFDKII-KAEKENVIHLLDILFRQYDSLCSQYGLQKIETVGKTYMAAAGLK 1803
Query: 384 EARDDHAKC----CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFD 439
++ +++ +M + + + +++G+H G V V+G K QF
Sbjct: 1804 NIVSQNSANPVLRAIQVAFEMRKFASQQDFCGSGEIIVKIGVHYGNVIAGVIGYHKPQFS 1863
Query: 440 VWSNDVTLANYMESGGVAGRVHITKE 465
+ + V + + S G G++ I+++
Sbjct: 1864 LIGDTVNTTSRVCSTGQDGQIKISED 1889
>UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 418
Score = 114 bits (274), Expect = 7e-24
Identities = 61/181 (33%), Positives = 102/181 (56%), Gaps = 14/181 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP +A E+K + P +YI + ++LF D GFT +S+ + EEL+
Sbjct: 198 NILPVSIAAELKKNNRVSP-------VYIN---SATVLFTDFKGFTQISESMSPEELISN 247
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
L+E F+ FD++ A+H +IK +GD + CV G+PE H L M DAI ++E
Sbjct: 248 LDECFSLFDQICADHGLEKIKTIGDSFMCVGGVPEVNRTHVFDVALAALKMCDAIQKLKE 307
Query: 410 VMAVN----VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
N ++R+G HTG V V+G K+ +D+W + V +A+ MES G G++++++E
Sbjct: 308 EKNKNGISYWDVRIGFHTGPVAAGVIGKNKFSYDIWGDTVNIASRMESSGEPGKINVSEE 367
Query: 466 T 466
+
Sbjct: 368 S 368
>UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_151, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2641
Score = 114 bits (274), Expect = 7e-24
Identities = 58/157 (36%), Positives = 95/157 (60%), Gaps = 6/157 (3%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
++ +++ E ++LFADI GFT S + E++V +L LF FD+ + ++ +GD
Sbjct: 2429 EVLVEQLEEATLLFADIAGFTEYSSKVEPEQVVNMLRNLFTEFDKKCLTQNTYKLYTIGD 2488
Query: 375 CYYCVSGLPEARD----DHAKCCVEMGLDMIDAIALVREVMAVN-VNMRVGIHTGRVHCV 429
CY V G+ + R AK VE+G MI+ I VR+++ + ++MR+GIHTG+V
Sbjct: 2489 CYVAV-GIIDIRQRNPAQEAKNVVELGFGMIEIIRNVRQIIGFDGLDMRIGIHTGKVIAG 2547
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+LG ++DV+ DV ++N MES G GRV +++ET
Sbjct: 2548 ILGTEIVRYDVYGADVMISNKMESNGEKGRVQVSEET 2584
Score = 76.6 bits (180), Expect = 2e-12
Identities = 48/150 (32%), Positives = 78/150 (52%), Gaps = 8/150 (5%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGL 382
NVSILF DICGF L E +V++L+ LF FD+L A++ +++ +G Y GL
Sbjct: 1799 NVSILFCDICGFDDLIT-VEKENIVKILDGLFRSFDQLCAQNGMQKVETVGKTYMAAGGL 1857
Query: 383 PEA-------RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
+ K V++ L+M+D V+ ++ +++GIH GRV V+G K
Sbjct: 1858 KAVDQGTKFYNQNCVKRAVQLSLEMMDHTRKVKYGQIGHLTIKIGIHYGRVIAGVIGHHK 1917
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
QF + + V + + S G G+V ++ E
Sbjct: 1918 PQFSLIGDTVNTTSRVCSTGQDGQVTLSNE 1947
>UniRef50_Q4SU92 Cluster: Chromosome 3 SCAF13974, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 3 SCAF13974, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1108
Score = 113 bits (273), Expect = 9e-24
Identities = 71/176 (40%), Positives = 102/176 (57%), Gaps = 8/176 (4%)
Query: 192 SLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDN--SSDMQLYCTIATL-IACNAA 248
SLF+ TY LP+ L + + G + +++ L + ++ ++ + A L +A N A
Sbjct: 142 SLFS--TYTLLPLPLLWSIVTGTITSVLDLVLDLFFHHGDAAVVRKVSSKALLYLAMNLA 199
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQP 308
G+ H + QR++FLETR C+E S+LPR + ++M D+A
Sbjct: 200 GLFIHYLSDRTQRQSFLETRRCIEGRVRLERENQRQERLVMSILPRFLVLDMIGDMAPVD 259
Query: 309 RH---EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLA 361
+ +QFHKIYI Y++VSILFADI GFTSLS +A+ELVR LNELF RFDRLA
Sbjct: 260 DYLLPQQFHKIYIHHYKDVSILFADIIGFTSLSLILSAQELVRTLNELFGRFDRLA 315
Score = 68.9 bits (161), Expect = 3e-10
Identities = 28/52 (53%), Positives = 40/52 (76%)
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAG 458
VR + + ++MR+G+H+G V C VLGL+KWQFD+WS DV +AN +E+ GV G
Sbjct: 390 VRREIQLELDMRIGVHSGSVLCGVLGLQKWQFDIWSWDVDIANSLEAAGVPG 441
Score = 61.7 bits (143), Expect = 5e-08
Identities = 55/195 (28%), Positives = 83/195 (42%), Gaps = 39/195 (20%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAE----ELVRLLNELFARFDRLAAEHH---CL 367
++Y Q Y+ V +LFA + GF+ +Q A E +RLLN + FD L E +
Sbjct: 830 ELYSQSYQRVGVLFASLPGFSRYYEQKEAADRHFECLRLLNHIITDFDELLDESYFQDVE 889
Query: 368 RIKLLGDCYYCVSGLPEARDDHAKC---------CVEMGLDMIDAIALVREVMAVNVNMR 418
+IK +G Y SGL R +C V L M + ++ + + +R
Sbjct: 890 KIKTMGSSYMAASGLSPDRQSVQECEDAWHHLGELVLFALSMQETLSHINTDTGNSFQLR 949
Query: 419 VG-------------------IHTGRVH----CVVLGLRKWQFDVWSNDVTLANYMESGG 455
VG TG H V+G K Q+D+W V LA+ MES G
Sbjct: 950 VGDNNKKKRELMKALDSPPLATSTGVAHGPVIAGVIGATKPQYDIWGTTVNLASRMESTG 1009
Query: 456 VAGRVHITKETLCCL 470
++G + + + T C L
Sbjct: 1010 ISGMIQVPEATSCIL 1024
>UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; n=1;
Trichodesmium erythraeum IMS101|Rep: Adenylate/guanylate
cyclase precursor - Trichodesmium erythraeum (strain
IMS101)
Length = 1209
Score = 113 bits (273), Expect = 9e-24
Identities = 54/151 (35%), Positives = 92/151 (60%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
I + ++ V++LFAD+ GFT L+ + LV LNE+F++FD LA ++ +IK +GD
Sbjct: 1023 IIAEGFDEVTVLFADLVGFTQLASSVYPKRLVYWLNEIFSKFDLLAEKYGLEKIKTIGDA 1082
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y V GLP ++HA+ + +DM + +A + +R+GI+TG V V+G +K
Sbjct: 1083 YMVVGGLPTPMENHAEAIALIAIDMREELAHFAHKSKQDFLIRIGINTGPVVAGVIGRKK 1142
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +D+W + V +A+ MES G+ G + +T+ T
Sbjct: 1143 FIYDLWGDTVNIASRMESQGIPGVIQVTEAT 1173
>UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n=1;
Beggiatoa sp. PS|Rep: Rh-like protein/ammonium
transporter - Beggiatoa sp. PS
Length = 391
Score = 113 bits (273), Expect = 9e-24
Identities = 59/157 (37%), Positives = 90/157 (57%), Gaps = 1/157 (0%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+ V++LFADI GFT++S Q +LV LN F+ D ++ +IK +GDCY V+
Sbjct: 206 FAEVTVLFADISGFTNMSTQIPPHQLVETLNLFFSEIDLQVEKYGIEKIKTIGDCYMAVA 265
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
G+P +HA E+ LD I +A E++ + MR+G+H+G V V+G RK+ +D+
Sbjct: 266 GIPFPCSNHAVRIAEIALD-IHEMAKNYEMLGKPLQMRIGLHSGPVIAGVIGKRKFIYDL 324
Query: 441 WSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
W + V A+ MES G+ G +T+ T L DY E
Sbjct: 325 WGDTVNTASRMESHGIPGETQVTEGTYLRLKTDYIFE 361
>UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2;
Caenorhabditis|Rep: Guanylate cyclase - Caenorhabditis
elegans
Length = 1012
Score = 113 bits (273), Expect = 9e-24
Identities = 65/194 (33%), Positives = 110/194 (56%), Gaps = 16/194 (8%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA ++K + +P + ++ V+I F+D+ FT+L+ +CT ++V LL
Sbjct: 797 MLPKQVAEKLKLGQSVEP----------ETFDCVTIFFSDVVSFTTLASRCTPLQVVNLL 846
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIALVR- 408
N+L+ FD + +H +++ +GD Y CVSGLP ++HAK M ++ AI R
Sbjct: 847 NDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRV 906
Query: 409 -EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ +N+RVG+HTG V V+G+ ++ ++ + V A+ MES G GRVHI+ E +
Sbjct: 907 PHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECM 966
Query: 468 CCLGD---DYKVEP 478
L + Y+ EP
Sbjct: 967 KFLTEVIGGYQTEP 980
>UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12;
Coelomata|Rep: Soluble guanylate cyclase 88E -
Drosophila melanogaster (Fruit fly)
Length = 947
Score = 113 bits (273), Expect = 9e-24
Identities = 53/159 (33%), Positives = 101/159 (63%), Gaps = 1/159 (0%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +++VSILF+DI FT + + T E+V +LN +++ FD+L + +++ +GD Y
Sbjct: 415 EMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMV 474
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
V+G P+ +HA+ +M LDM+DAI +++ ++ +RVG+H+G V ++GL+ +
Sbjct: 475 VAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPR 534
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+ ++ + V A+ MES +A +VHI++ T +G +YK+
Sbjct: 535 YCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKI 573
>UniRef50_A0BG69 Cluster: Chromosome undetermined scaffold_105, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_105, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2473
Score = 113 bits (272), Expect = 1e-23
Identities = 58/163 (35%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + ++E+ ++LFADI GFT S + E++V +L LF FD++ + ++ +GDC
Sbjct: 2253 VLVDQFEDATLLFADIAGFTEYSSRVEPEQVVNMLRNLFTEFDKICLTQNAYKLYTIGDC 2312
Query: 376 YYC---VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN-VNMRVGIHTGRVHCVVL 431
Y V AK VE+G MID I VR ++ + ++MR+GIHTG+V +L
Sbjct: 2313 YVAFGIVDVTQRNPAQEAKNVVELGFKMIDIIRQVRSIIGFDGLDMRIGIHTGKVIGGIL 2372
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
G ++DV+ DV ++N MES G G+V +++ET L Y
Sbjct: 2373 GTEIVRYDVYGADVMISNKMESNGERGKVQVSEETKQLLEQSY 2415
Score = 68.5 bits (160), Expect = 4e-10
Identities = 45/149 (30%), Positives = 71/149 (47%), Gaps = 8/149 (5%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
VSILF DICGF L E +V LL+ LF FD L + +I+ +G + GL
Sbjct: 1628 VSILFCDICGFDDLI-AVEKENIVNLLDSLFRGFDGLCVSNGMQKIETVGKTFMAAGGLK 1686
Query: 384 EA-------RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKW 436
K V++ L+M++ + + NV +++G+H GRV V+G K
Sbjct: 1687 AVDQGTKFINQSAVKRAVQLSLEMMEYAKKFKFGQSGNVKIKIGVHYGRVIAGVIGHHKP 1746
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKE 465
QF + + V + + S G G + ++ E
Sbjct: 1747 QFSLIGDTVNTTSRVCSTGQDGEITLSNE 1775
>UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 2814
Score = 112 bits (269), Expect = 3e-23
Identities = 57/154 (37%), Positives = 94/154 (61%), Gaps = 6/154 (3%)
Query: 318 IQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYY 377
+ +E+V+ILFADI GFT S Q E++V +L +LF FD+ E+ ++ +GDC Y
Sbjct: 2444 VDNFEDVTILFADIAGFTKYSSQVDPEQVVNMLKKLFYEFDKACQENEIFKLYTIGDC-Y 2502
Query: 378 CVSGLPEARD----DHAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLG 432
V G + R + AK + MG +MI+ I +R +V +++MR+G+HTG++ V+G
Sbjct: 2503 VVIGFTDIRKRNPAEEAKNVLNMGFNMIEIIKQLRAQVKFESLDMRIGVHTGKIIGGVIG 2562
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++D++ DV +AN MES G GR+ ++ +T
Sbjct: 2563 TDIVRYDIYGRDVVIANKMESSGEQGRILVSSQT 2596
Score = 69.7 bits (163), Expect = 2e-10
Identities = 48/160 (30%), Positives = 82/160 (51%), Gaps = 13/160 (8%)
Query: 318 IQRYEN---VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
IQ EN V++LF DIC F ++ Q +E++V LL+ LF FD L +++ C +I+ +G
Sbjct: 1757 IQLAENQGEVAVLFCDICDFDNIL-QSESEKIVALLDNLFRNFDILCSQNDCTKIETVGK 1815
Query: 375 CYYCVSGLP---EARDDH-----AKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGR 425
Y SGL + + H + + +G DM D + + + +++GIH GR
Sbjct: 1816 TYVAASGLSLELQNKKKHTVYNSVERLINLGFDMQDYVKNISWGKHGDKMRVKIGIHYGR 1875
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V V+G K QF + + + + + S G R+ I+ +
Sbjct: 1876 VMAGVIGYHKPQFSLIGDTINTTSRVMSTGEDNRMTISSQ 1915
>UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 582
Score = 112 bits (269), Expect = 3e-23
Identities = 64/180 (35%), Positives = 106/180 (58%), Gaps = 13/180 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSL--SDQCTAEELV 347
S+LP+ VA +++ + + + Y+ V+ILF+DI GFT+L +D+ ++V
Sbjct: 411 SILPKEVAAKLRLN----------QSVPAESYKTVTILFSDIVGFTALCSNDKIVPMDIV 460
Query: 348 RLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALV 407
++LN L+ FD L+ + +++ +GD Y V GLP +DHA MGL M++A +V
Sbjct: 461 KMLNRLYTYFDMLSGMNDVYKVETIGDAYMVVGGLPHPCEDHADRVASMGLGMMEAADVV 520
Query: 408 -REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
V + +R+GIHTG V V+G + ++ ++ N VTLAN MESG GR++I+ +T
Sbjct: 521 LSPVDREPLKIRIGIHTGPVMAGVVGKKMPRYCLFGNTVTLANKMESGTQPGRINISIDT 580
>UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2700
Score = 111 bits (266), Expect = 6e-23
Identities = 57/154 (37%), Positives = 92/154 (59%), Gaps = 8/154 (5%)
Query: 321 YENVSILFADICGFTSLSDQCT-AEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
+++V++LFADI GFT SD+ ++++ +L LF FD L +H ++ +GDCY +
Sbjct: 2506 FDDVTVLFADIKGFTEFSDKVVDPKKVLLMLKNLFESFDGLCVKHQVFKLYTIGDCYVVL 2565
Query: 380 SGLPEARDD-------HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
S + R D AK + MGLDMI+ I +++ +NMR+GIHTG++ ++G
Sbjct: 2566 SFITAERQDTIAEKIEEAKKVINMGLDMIETINIIKGTAYPFLNMRIGIHTGKIIGGIMG 2625
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++DV+ DV +AN MES G G+V I++ T
Sbjct: 2626 TDVVRYDVYGKDVMIANKMESNGEPGKVMISEST 2659
Score = 48.8 bits (111), Expect = 4e-04
Identities = 34/135 (25%), Positives = 66/135 (48%), Gaps = 13/135 (9%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
+ V+ILFAD+C + ++ +V L+++LF FD + +H +I+ +G Y +G
Sbjct: 1940 DEVAILFADVCDMDEIMEK-EGNNIVYLIDDLFRAFDFICEKHGAQKIETVGKTYMAATG 1998
Query: 382 LPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVN-----------MRVGIHTGRVHCVV 430
+ E D + G + + + +E++ V N +++GI+ G+V V
Sbjct: 1999 IIECEVDLDNNLKQKGKG-VRLLNMAKEMIDVAQNKKYGNGYKSFCLKIGINKGKVMAGV 2057
Query: 431 LGLRKWQFDVWSNDV 445
+G K QF + + V
Sbjct: 2058 IGNPKPQFSLIGDTV 2072
>UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_36, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2471
Score = 111 bits (266), Expect = 6e-23
Identities = 60/158 (37%), Positives = 93/158 (58%), Gaps = 4/158 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
Y + +ILFADI GFT S EE+V +L LF FD+L H+ ++ +GDCY +
Sbjct: 2284 YNDCTILFADIAGFTKYSSSVQPEEVVSMLKNLFDEFDKLTQIHNVFKLYTIGDCYVVIG 2343
Query: 381 GLPEARDD---HAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRKW 436
+ D A VEM L+M++AI+LVR ++ +++MR+GIHTG V ++G
Sbjct: 2344 VTDNFKRDPIQEAFNVVEMSLNMLEAISLVRNQINYHDLHMRIGIHTGNVIGGIIGTDII 2403
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
++DV+ D+ +AN MES GRV I++ T + D++
Sbjct: 2404 RYDVYGKDILIANKMESSSEEGRVLISETTKKLIEDNF 2441
Score = 53.6 bits (123), Expect = 1e-05
Identities = 37/149 (24%), Positives = 75/149 (50%), Gaps = 15/149 (10%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R +Q H + + V I+F D+C F + + + +V+L++ ++ +FD++ + +C +
Sbjct: 1572 RLDQGHLDFSENQGLVGIIFVDMCSFDVIVSE-EDQNIVQLMDNIYRQFDQICSSTNCQK 1630
Query: 369 IKLLGDCYYCVSGLP-----EARDDHAKCCVEMGLDMIDAIALVREVM-------AVNVN 416
I+ +G Y SGL + + H K +E +++ A + +E+ +
Sbjct: 1631 IETVGKTYMACSGLKCVEKFQPKGQHLKNPIERLVEL--AFGIQQEITNFKWGTNQKSFG 1688
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDV 445
+++GIH GRV V+G K QF + + V
Sbjct: 1689 LKIGIHYGRVLMGVIGSIKPQFSLIGDTV 1717
>UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep:
Cyclase - Rhizobium loti (Mesorhizobium loti)
Length = 356
Score = 110 bits (265), Expect = 8e-23
Identities = 61/189 (32%), Positives = 98/189 (51%), Gaps = 12/189 (6%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP +A +KAD H + VS+LFADI GFT + A + +
Sbjct: 161 NILPASIAERLKADEQIADNHAE-----------VSVLFADIVGFTERARSVGAVTTLAI 209
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN F DRL+ ++ C +IK +GDC V+GLP AR DHA+ L++ +A+ R
Sbjct: 210 LNYFFKAADRLSEQYGCEKIKTIGDCVMVVAGLPAARPDHAEALARYALELREAVQHER- 268
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
+ +R+GIH+G + V+G R++ +D+W V LA +++ + I+ T
Sbjct: 269 FAGERLRLRIGIHSGPIVAGVIGKRRFAYDLWGETVNLAARIQTSAEPDEIRISDATRRL 328
Query: 470 LGDDYKVEP 478
LG D+ +P
Sbjct: 329 LGPDFACDP 337
>UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 622
Score = 110 bits (265), Expect = 8e-23
Identities = 50/150 (33%), Positives = 96/150 (64%), Gaps = 2/150 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ + NV+ILF+D+ GFT++ ++V +LN ++ FD+L+ +H+ +++ +GD Y
Sbjct: 441 ETFSNVTILFSDVVGFTTICSLIAPMQVVTMLNCMYTTFDKLSEKHNVYKVETIGDAYMV 500
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN--VNMRVGIHTGRVHCVVLGLRKW 436
VSG+PE HA+ +M L+M+ A+ + + +N + +R+GIHTG V V+GL+
Sbjct: 501 VSGIPERTKYHAEHVADMALNMLSAMPEIEDPAGLNDHLRIRIGIHTGTVVAGVVGLKMP 560
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G+A +H++++T
Sbjct: 561 RYCLFGDTVNTASRMESTGLAMAIHVSEDT 590
>UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, whole
genome shotgun sequence; n=6; Eukaryota|Rep: Chromosome
undetermined scaffold_63, whole genome shotgun sequence -
Paramecium tetraurelia
Length = 2465
Score = 110 bits (264), Expect = 1e-22
Identities = 62/161 (38%), Positives = 96/161 (59%), Gaps = 6/161 (3%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
+ ENV+ILFADI GFT S + T EE++ +L LF FDR E + ++ +GDCY
Sbjct: 2254 KIENVTILFADIAGFTEYSSKVTPEEVLLMLKNLFVEFDRKCYELNVYKLYTIGDCYVAF 2313
Query: 380 SGLPEARD----DHAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLR 434
G+ + + + AK V++ +MI I +VR ++ ++MR+GIHTG V V+G
Sbjct: 2314 -GMIDYNERNPTEEAKNIVDLAFEMIRIIEVVRKQINFDGLDMRIGIHTGCVLGGVMGTD 2372
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
++D++ DV +AN MES G G+VH+++ T L DY+
Sbjct: 2373 IVRYDIYGPDVLIANKMESNGKKGQVHVSEITKQLLEQDYE 2413
Score = 50.8 bits (116), Expect = 9e-05
Identities = 39/156 (25%), Positives = 73/156 (46%), Gaps = 10/156 (6%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
Q NV+I+F DIC F + + E ++ L++LF FD+ +I+ +G Y
Sbjct: 1665 QNQGNVAIVFCDICNFDQIIME-EQENIISFLDDLFRTFDKYCEICGVQKIETVGKTYMA 1723
Query: 379 VSGLPEARDDHAKCC----VEMGLDMIDA-IALVREVMAVNVNM----RVGIHTGRVHCV 429
+GL + A V+ L++ + I +R + + + ++GIH GR
Sbjct: 1724 AAGLKACEQELAYLSEIQPVQRALNLAEMMITYIRSKLWGHQSQPLIGKIGIHYGRAISG 1783
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V+G K QF + + V + + S G R+ ++++
Sbjct: 1784 VIGFHKPQFSLIGDTVNTTSRVCSTGQEDRIILSEK 1819
>UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 366
Score = 109 bits (263), Expect = 1e-22
Identities = 55/151 (36%), Positives = 88/151 (58%), Gaps = 4/151 (2%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
RYENV++LF D+ GFT +++ + EEL+ L+ F FD + +H +IK +GD Y
Sbjct: 153 RYENVTVLFTDMAGFTKIAESMSPEELLSELDLFFREFDLITKKHGMEKIKTIGDSYMAA 212
Query: 380 SGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN----VNMRVGIHTGRVHCVVLGLRK 435
GLP + H+ V GL+ + L ++ N +R+GIH+G V V+G +K
Sbjct: 213 GGLPIVNNTHSIDAVLCGLEFQKFMRLKKKERENNHLPFWELRLGIHSGSVVAGVVGTKK 272
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +D+W + V A+ MES G+ G V+I++ET
Sbjct: 273 FAYDIWGDSVNTASRMESSGIPGEVNISQET 303
>UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1146
Score = 109 bits (263), Expect = 1e-22
Identities = 60/178 (33%), Positives = 105/178 (58%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA ++KA I+ +P + +E V+I F+D+ FT+L+ +CT ++V+LL
Sbjct: 916 MLPKTVAEKLKAGISIEP----------ETFELVTIFFSDVVQFTTLASKCTPLQVVQLL 965
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIA--LV 407
N+L+ FD + ++ +++ +GD Y CVSGLP DH K M L + ++A V
Sbjct: 966 NDLYTIFDSIIEQNDVYKVETIGDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRV 1025
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ + +N+R+GI+ G V V+GL ++ ++ + V A+ MES G GR+H++ E
Sbjct: 1026 AHMPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSE 1083
>UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_86, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2476
Score = 109 bits (263), Expect = 1e-22
Identities = 63/176 (35%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
+Q + ++E+V++LFADI GFT S + E++V +L LF FD+ E + ++
Sbjct: 2267 QQSRAVLKDQHEDVTLLFADIAGFTEYSSKVAPEQVVFMLRNLFTEFDKCCQEKNVYKLY 2326
Query: 371 LLGDCYYCVSGLPEARDDH----AKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIHTGR 425
+GDC Y V G+ +A+D + AK VEM +MI+ I VR+ + +++MR+GIHTG+
Sbjct: 2327 TIGDC-YVVMGMVDAKDRNPALEAKNTVEMAFEMINIIRKVRDKINNSDLHMRIGIHTGK 2385
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHI---TKETL-CCLGDDYKVE 477
+ VLG ++D++ DV +AN MES G+V + TK+TL C ++++ +
Sbjct: 2386 IIGGVLGTDIVRYDIYGPDVLIANKMESKSERGQVQVSETTKKTLELCYPEEFQYQ 2441
Score = 53.6 bits (123), Expect = 1e-05
Identities = 36/146 (24%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+ILF DIC F ++ + + +V LL+ LF ++D L +++ +I+ +G Y SGL
Sbjct: 1698 VAILFCDICEFDTII-KVQQQNVVHLLDILFRQYDSLCNQYNLQKIETVGKTYMAASGLK 1756
Query: 384 EARDDH----AKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFD 439
+ +++ +M + N+ +++G+H G V V+G K QF
Sbjct: 1757 NLISQNNINPVFRALQVAFEMQKFASSQSFGQTENIVVKIGVHYGNVIAGVIGYHKPQFS 1816
Query: 440 VWSNDVTLANYMESGGVAGRVHITKE 465
+ + V + + S ++ I++E
Sbjct: 1817 LIGDTVNTTSRVCSTAQDNQIKISEE 1842
>UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1276
Score = 109 bits (262), Expect = 2e-22
Identities = 52/153 (33%), Positives = 93/153 (60%), Gaps = 2/153 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + Y+ V+I F+DI GFTSLS Q T ++V LLN+L+ FD + +++ +GD
Sbjct: 1077 VQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDA 1136
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGL 433
Y VSGLPE RDDHA +M L ++ + ++R + +R+G+H+G V V+G
Sbjct: 1137 YMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGS 1196
Query: 434 RKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ ++ ++ + V ++ MES G+ ++H++++T
Sbjct: 1197 KMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQT 1229
>UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_12, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2459
Score = 109 bits (262), Expect = 2e-22
Identities = 56/149 (37%), Positives = 94/149 (63%), Gaps = 6/149 (4%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGL 382
+ ++LFADI GFT+ S AE++V++L +L FD+ + + ++ +GDCY V G+
Sbjct: 2263 DATLLFADISGFTAYSASVPAEQVVKMLRQLMTSFDKECLQQNVYKVYTIGDCYV-VLGI 2321
Query: 383 PEARDDH----AKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
+ H AK +EMGL+M++ I VR E+ N+NMR+GIHTG+ + ++G +
Sbjct: 2322 NDMEQRHPGQEAKNVLEMGLEMVEIIKKVRREINFQNLNMRIGIHTGQFYGGIIGTDIVR 2381
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET 466
+D++ D +AN MES G AG+V ++++T
Sbjct: 2382 YDIFGIDAVIANKMESQGEAGKVMVSEDT 2410
Score = 62.5 bits (145), Expect = 3e-08
Identities = 47/175 (26%), Positives = 87/175 (49%), Gaps = 21/175 (12%)
Query: 311 EQFHKIYIQRYE-NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRI 369
EQ + I+ + +VSI+F +IC F + Q ++V L+++F D++ ++ +I
Sbjct: 1637 EQAEETQIEENQGSVSIIFLEICEFDKIL-QSKQRQVVSFLDDIFRVLDKICLQYGVQKI 1695
Query: 370 KLLGDCYYCVSGLPEARDDHAK------------CCVEMGLDMIDAIALVR------EVM 411
+ +G Y SGL ++ K +E+ LD + A++ R E++
Sbjct: 1696 ETVGKTYMACSGLKSTEIENNKDGLNQQKKNETALALELSLDFLKAVSEFRYEYKEQEIV 1755
Query: 412 AV-NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ + +++GIH G+V V+G K QF + + V A+ M S G GR+ I+ E
Sbjct: 1756 KLYKLKIKIGIHYGQVFAGVIGYHKPQFSLIGDTVNTASRMCSTGEVGRITISSE 1810
>UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Paramecium
tetraurelia|Rep: Cation-transporting ATPase - Paramecium
tetraurelia
Length = 2302
Score = 109 bits (261), Expect = 3e-22
Identities = 57/154 (37%), Positives = 92/154 (59%), Gaps = 4/154 (2%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCY 376
+I +E+V++LFADI GFT S T E +V +L LF FD+L ++ ++ +GDCY
Sbjct: 2101 FIDEFEDVTLLFADIKGFTEYSHTQTPEGVVTMLRNLFTEFDKLCQRYNVYKMYTIGDCY 2160
Query: 377 YCVSGLPEARDD---HAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLG 432
+ A+ + A V+MG M++ I VR ++ +NMR+GIHTG+V ++G
Sbjct: 2161 VVMGFTNSAKRNPIQEAINTVKMGFQMVEIIMQVRLKIKFDKLNMRIGIHTGQVTGGIIG 2220
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++D++ DV++AN MES G GRV +++ T
Sbjct: 2221 TDIVRYDIYGKDVSIANKMESSGEEGRVQVSQTT 2254
Score = 64.9 bits (151), Expect = 5e-09
Identities = 42/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
Q ++VSILFA IC F ++ + + +V +L+ LF +D L +H +I+ +G Y
Sbjct: 1564 QAQDDVSILFAYICDFDTIMKE-EGKNVVLMLDSLFRLYDNLCIQHGVQKIETVGYTYMA 1622
Query: 379 VSGLPEA---------RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCV 429
+G+ R + V M DM+ + + + M++GIH GRV
Sbjct: 1623 ATGIKACEQNMTAHVIRTEKTMRLVNMAFDMMQQVQGRKYGKGNQIEMKIGIHVGRVIAG 1682
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V+G K QF + + V + + S G G + ++++
Sbjct: 1683 VIGHHKPQFSLIGDPVNQTSRVGSTGDTGAITLSEQ 1718
>UniRef50_UPI0000E47CE0 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 364
Score = 108 bits (260), Expect = 3e-22
Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 24/254 (9%)
Query: 132 VLGLSALVFAC--LLACLSRPAMNEIYLLTISY-VVLVAFLLIEFSFAGTSVLRSLTVST 188
VLG +A + LL CL + E + S + L +L++ S ++R V T
Sbjct: 95 VLGRAASLIGATFLLTCLLALSCLEFIVPRFSSPLALFLWLILLISTYTIQIMRPAHVPT 154
Query: 189 GACSLFTYVTYAT---LPVRLHEATIGGLALAAVNIGAHLLLDNSSD-----MQLYCTIA 240
L + T A LPV A + G ++ +L + + +++ I
Sbjct: 155 DGVGLVLFTTLAVHTMLPVSHIVAVVIGALTCLPHVILSAILGSHDEPIDKLLKILSNIV 214
Query: 241 TLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEM 300
+ N G+ ++AQRR FL+TR C+E+ SVLP H+A EM
Sbjct: 215 MFVCVNFIGVCHKHLLDVAQRRTFLDTRSCIESRIKLEHEQAQQERLLLSVLPAHLAYEM 274
Query: 301 KADIASQPR--------HE-----QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELV 347
K ++ ++ R H FH +Y++R++NVSIL+ADI GFT+L+ +C+ ELV
Sbjct: 275 KTEMMARVRDPTMSPISHRPSSSTHFHSLYVKRHKNVSILYADIVGFTALASECSPPELV 334
Query: 348 RLLNELFARFDRLA 361
+ LNELF RFD+LA
Sbjct: 335 KTLNELFGRFDQLA 348
>UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1174
Score = 108 bits (260), Expect = 3e-22
Identities = 63/186 (33%), Positives = 104/186 (55%), Gaps = 13/186 (6%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
++PR VA +K + +P EQF E V++ F+DI F +LS+Q +V L+
Sbjct: 928 MMPRQVANSLKLGQSVEP--EQF--------ECVTVFFSDIVQFAALSNQMRPLHVVNLM 977
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIALVR- 408
NEL+ FD + EH +++ +GD Y CVSGLP + HAK C +M L ++++ R
Sbjct: 978 NELYTTFDAIVDEHDVYKVESIGDGYLCVSGLPNRNGNLHAKQCADMALKFLNSLQSFRI 1037
Query: 409 -EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
E + +R+G+H+G V+GL ++ ++ + V A+ MES A ++HI+KET
Sbjct: 1038 SEHSDQRIRLRIGLHSGPCVAGVVGLAMPRYCLFGDTVNTASRMESSSSANKIHISKETC 1097
Query: 468 CCLGDD 473
L ++
Sbjct: 1098 ILLHEN 1103
>UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1;
Microscilla marina ATCC 23134|Rep: Adenylate or
guanylate cyclase - Microscilla marina ATCC 23134
Length = 774
Score = 108 bits (259), Expect = 4e-22
Identities = 64/190 (33%), Positives = 101/190 (53%), Gaps = 14/190 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP A E+K + P+H Y VS+LF D GFT L+++ T E++
Sbjct: 571 NILPYATAQELKEKGNATPQH----------YPKVSVLFTDFKGFTKLAEKLTPTEVIAE 620
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIA---L 406
LN F+ FD + +++ +IK +GD Y G+P A D + ++ GL+M +A
Sbjct: 621 LNYCFSAFDDICQKYNIEKIKTIGDAYMAAGGIPVANDTNPIDTIKAGLEMQTFMAQWKT 680
Query: 407 VREVMAVNV-NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+E + V +R+GIHTG V V+G K+ +DVW + V LA MES G G V+I+
Sbjct: 681 NKEAQGLPVWELRLGIHTGEVVAGVVGKNKFAYDVWGDTVNLAARMESSGAPGMVNISGH 740
Query: 466 TLCCLGDDYK 475
T + D ++
Sbjct: 741 TYQLIKDQFE 750
>UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2;
Culicidae|Rep: Soluble guanylate cyclase gcy - Aedes
aegypti (Yellowfever mosquito)
Length = 1025
Score = 107 bits (258), Expect = 6e-22
Identities = 53/159 (33%), Positives = 97/159 (61%), Gaps = 1/159 (0%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ + +VSILF+D+ FT + + T E+V +LN +++ FD L ++ +++ +GD Y
Sbjct: 418 EMFNSVSILFSDVVTFTEICSRITPMEVVSMLNAMYSIFDTLTERNNVYKVETIGDAYMV 477
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
VSG PE +HA+ +M LDMI+AI +++ ++ +RVG+H+G V ++GL+ +
Sbjct: 478 VSGAPEKEQNHAEKVCDMALDMIEAITDLKDPSTGSHLRIRVGVHSGAVVAGIVGLKMPR 537
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+ ++ + V A+ MES A ++HI++ T L +Y V
Sbjct: 538 YCLFGDSVNTASRMESTSQAMKIHISQSTRNFLPSNYHV 576
>UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 1213
Score = 107 bits (257), Expect = 8e-22
Identities = 67/189 (35%), Positives = 99/189 (52%), Gaps = 9/189 (4%)
Query: 318 IQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYY 377
I + +NV+ LFADI GFT S E +V +L LF FD+ + + +I +GDC Y
Sbjct: 1021 IDQLDNVTFLFADIAGFTKYSGSVQPENVVNMLRILFNEFDQQCQKKNLYKIYTIGDC-Y 1079
Query: 378 CVSGLPEARD-----DHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVL 431
V G A + + AK VE+G +MI+ I VR ++ + MR+G+HTG V+
Sbjct: 1080 VVIGTKNASNRLRPHEEAKNVVELGFEMIEIIKKVRSIVQFEELEMRIGVHTGSYIGGVI 1139
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKD- 490
G ++D++ DV +AN MES G G+V ++K T+ L D Y Y+K
Sbjct: 1140 GTDIVRYDIYGPDVMIANKMESNGEQGKVMVSKTTMNLLYDHYGSRYNFTKGNEVYIKQF 1199
Query: 491 -HNIETYLI 498
+IE Y I
Sbjct: 1200 HKHIEGYFI 1208
Score = 67.3 bits (157), Expect = 1e-09
Identities = 45/150 (30%), Positives = 74/150 (49%), Gaps = 9/150 (6%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
VSILF DIC F + E +VRL+++LF FD L +I+ +G Y GL
Sbjct: 241 VSILFCDICDFEQILS-AEQENIVRLVDKLFRSFDSLCNHAGLQKIETVGKTYMAAGGLK 299
Query: 384 EARDDHAKC--------CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
++ + ++ V M +M+D I V +++GIH GRV V+G K
Sbjct: 300 DSENKKSQYKQINPVARAVIMSFEMMDIIKQFNYGDNEKVKIKIGIHYGRVIAGVIGCHK 359
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
QF + + V A+ + S G G++ ++++
Sbjct: 360 PQFSLIGDTVNTASRVCSTGDVGQITLSEQ 389
>UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_20, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2620
Score = 107 bits (257), Expect = 8e-22
Identities = 65/188 (34%), Positives = 103/188 (54%), Gaps = 9/188 (4%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
EN ++LFADI GFT S E +V +L LF+ FD+ + ++ +GDCY C+
Sbjct: 2428 ENATVLFADIAGFTKYSSSVEPETVVDMLRNLFSNFDQYCQKAEIYKLFTIGDCYVCMGV 2487
Query: 382 LP-EARD--DHAKCCVEMGLDMIDAI-ALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
L + RD A+ + G MI+ I ++ ++NMR+G+HTGRV V+G +
Sbjct: 2488 LDCKKRDPAGEAQKVLAFGFSMIEIINHYKKDPQYQHLNMRIGVHTGRVLGGVVGTDVVR 2547
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY-RNAYLKDHN--IE 494
+D++ DVT+AN MES G G++ +++ T + ++Y E Y ++ YL N I
Sbjct: 2548 YDIYGEDVTIANLMESSGQEGKILVSEITKNLVENEY--EGFQFDYAKDVYLPSKNLTIS 2605
Query: 495 TYLIVPDD 502
TY + P D
Sbjct: 2606 TYYVSPSD 2613
Score = 60.5 bits (140), Expect = 1e-07
Identities = 40/163 (24%), Positives = 80/163 (49%), Gaps = 10/163 (6%)
Query: 323 NVSILFADICGFTS-LSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
+VS+LF DI F + DQ E+++ L+ ++ FD+L + +I+ +G Y G
Sbjct: 1650 DVSVLFCDIYQFDKVIKDQ--QEKIIEFLDTIYRAFDQLCQNYDLQKIETVGKTYMAAGG 1707
Query: 382 LPE-------ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
L + + +E + M++ + ++ +V +++GIH GRV V+G+
Sbjct: 1708 LKDYDVVINQKNANSTSRALETAIQMMETVKTMKYGDNQDVQLKIGIHYGRVIAGVIGVH 1767
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
K QF + + V + + S G AG + +++ + D+ K +
Sbjct: 1768 KPQFSLIGDTVNTTSRVCSTGEAGFITLSEAAYLHVKDNTKYQ 1810
>UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta
proteobacterium MLMS-1|Rep: Adenylate cyclase - delta
proteobacterium MLMS-1
Length = 480
Score = 107 bits (256), Expect = 1e-21
Identities = 68/268 (25%), Positives = 123/268 (45%), Gaps = 14/268 (5%)
Query: 214 LALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAA---GMLTHQPRELAQRRAFLETRDC 270
+ + V++ + +S++ C ++ A +LTH+ R + RR R+
Sbjct: 190 VGIVGVDLSVDAYMARTSEVLRACLYGLAVSLGLAVLLALLTHRVRSASHRRELKHQRER 249
Query: 271 VEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFAD 330
E ++LP +A+ +K+ ++ +E V+++F D
Sbjct: 250 REKERELALQNQENERLLANILPGPIALRLKSG----------EELIADAHELVTVIFID 299
Query: 331 ICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHA 390
+ GFT S A +V LN +F D L ++ +IK +GD Y V GL D+H
Sbjct: 300 MTGFTRYSASHPARRVVDTLNRIFRMIDDLTLKYRLEKIKTIGDAYMMVGGLDPMDDNHP 359
Query: 391 KCCVEMGLDMI-DAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLAN 449
+ +M L+++ + L +E+ + ++RVGI TG V V+G K+ +D+W + V AN
Sbjct: 360 RRVADMALELMREFDRLKQELQVTDFSIRVGIATGPVVSGVIGSVKFAYDLWGDTVNAAN 419
Query: 450 YMESGGVAGRVHITKETLCCLGDDYKVE 477
+ES + GR+H L + Y+ E
Sbjct: 420 RLESSALPGRIHCNARFAHRLQEHYRFE 447
>UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 544
Score = 107 bits (256), Expect = 1e-21
Identities = 63/192 (32%), Positives = 107/192 (55%), Gaps = 14/192 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LPR VA E+K + K I++YE VS+LF D GFTS++++ T LVR
Sbjct: 311 NILPREVAEELK----------ESGKASIRQYEMVSVLFTDFKGFTSIAEKITPVALVRE 360
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM---IDAIAL 406
L F RFD + +++ +IK +GD Y G+P A + + GL+M ++ +
Sbjct: 361 LETCFLRFDEIIEKYNIEKIKTIGDAYMAAGGIPIANQTNPLDVILAGLEMQRYMNELKA 420
Query: 407 VREVMAVNV-NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
++ +R+GI+TG++ V+G +K+ +DVW + V A+ MES G G+V+I+ +
Sbjct: 421 AKQAAGEPYWELRLGINTGKLIAGVIGKKKFAYDVWGDTVNTASRMESSGEVGKVNISGK 480
Query: 466 TLCCLGDDYKVE 477
T + D ++ E
Sbjct: 481 TYELVKDFFECE 492
>UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena
pyriformis|Rep: Guanylyl cyclase - Tetrahymena pyriformis
Length = 2794
Score = 106 bits (254), Expect = 2e-21
Identities = 65/189 (34%), Positives = 100/189 (52%), Gaps = 9/189 (4%)
Query: 318 IQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYY 377
I +NV+ LFADI GFT S E +V +L LF FD+ + + +I +GDC Y
Sbjct: 2602 IDHLDNVTFLFADIAGFTKYSGSVQPENVVNMLRILFNEFDQQCQKKNLYKIYTIGDC-Y 2660
Query: 378 CVSGLPEARD-----DHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVL 431
V G A + + A+ VE+G +MI+ I VR ++ + MR+G+HTG V+
Sbjct: 2661 VVIGTKNANNRLRPHEEARNVVELGFEMIEIIKKVRSIVQFEELEMRIGVHTGSYIGGVI 2720
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKD- 490
G ++D++ DV +AN MES G G+V ++K T+ L ++Y + ++K
Sbjct: 2721 GTDIVRYDIYGPDVMVANKMESNGEQGKVMVSKTTMNLLLENYGNRYNFNKGNDVFIKQF 2780
Query: 491 -HNIETYLI 498
NIE Y I
Sbjct: 2781 HRNIEGYFI 2789
Score = 67.7 bits (158), Expect = 8e-10
Identities = 46/151 (30%), Positives = 74/151 (49%), Gaps = 9/151 (5%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGL 382
+VSILF DIC F + E +VR +++LF FD L +I+ +G Y GL
Sbjct: 1754 DVSILFCDICDFEQILST-EQENIVRTVDKLFRHFDGLCTHTGLQKIETVGKTYMAAGGL 1812
Query: 383 PEARDDHAKC--------CVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
+A ++ V M +M++A+ + +++GIH GRV V+G
Sbjct: 1813 KDAEGKKSQFRQINPVARAVIMSFEMMEAMKSFTYGDNEKIKIKIGIHYGRVIAGVIGCH 1872
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
K QF + + V +A+ + S G G+V I+ E
Sbjct: 1873 KPQFSLIGDTVNMASRVCSTGDVGQVTISDE 1903
>UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 2945
Score = 106 bits (254), Expect = 2e-21
Identities = 58/175 (33%), Positives = 99/175 (56%), Gaps = 6/175 (3%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
++++ +K + E V++LFADI GFTS S E+V++L LF FD+L +H +
Sbjct: 2727 QNKKQYKEISESLEKVTLLFADIAGFTSYSSNKQPSEVVKMLRNLFTSFDQLCLKHKVYK 2786
Query: 369 IKLLGDCYYCVSGLPEARDDHAKCC---VEMGLDMIDAIALVREVMA--VNVNMRVGIHT 423
+ +GDCY + + + + + C ++MG MI I ++ +VNMR+GIH
Sbjct: 2787 VYTIGDCYVVIGIVDKQNRQYQEECKNVIQMGFSMIQVIENIKREHEDFKSVNMRIGIHL 2846
Query: 424 G-RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
G +V ++G ++D++ DV +AN MES G GR++I+++T L + Y E
Sbjct: 2847 GEKVLGGIIGTNIVRYDIFGKDVVIANKMESNGQLGRINISEDTKKFLENHYPNE 2901
Score = 52.0 bits (119), Expect = 4e-05
Identities = 39/160 (24%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+ILF DIC F S+ ++ +L++ ++ L+ +FD++ E+ +I+ +G Y +GL
Sbjct: 2079 VAILFLDICDFDSILNE-EQTKLIKWIDNLYRQFDKICVEYGVQKIETVGKIYMACAGLK 2137
Query: 384 EARDDHAK----CCVEMGLDMIDAIALVREVMA--------VNVNMRVGIHTGRVHCVVL 431
+++ + E + + A ++ A ++++GIH G+V V+
Sbjct: 2138 LTKEEKLRQQKMLLTENETERLVLAAQEMQIKAKQYFWGNNQQTDVKIGIHYGKVIAGVI 2197
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLG 471
G K QF + + V A+ + S R+ ++ E LG
Sbjct: 2198 GAHKPQFSLIGDTVNTASRVCSKCKEKRISLSYEAHRRLG 2237
>UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Tetrahymena|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Tetrahymena thermophila SB210
Length = 2450
Score = 106 bits (254), Expect = 2e-21
Identities = 67/211 (31%), Positives = 116/211 (54%), Gaps = 13/211 (6%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+HV + D Q + ++F + ++V++LFADI GFTS S + E++V++L
Sbjct: 2247 LLPQHVLTKFFQD---QQKKQEFQ----ETLQDVTLLFADISGFTSYSSKSRPEDVVKML 2299
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE- 409
ELF FD+ + ++ +G + + + AK V+MG MI I VR+
Sbjct: 2300 RELFIEFDKSCITRNVYKVYTIGGMTNINNRIIH---EEAKNVVDMGFSMIKTIQYVRDK 2356
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
V ++ MR+GIHTG++ +LG ++D++ DV +AN +ES GV G++ +++ T
Sbjct: 2357 VNNSDLQMRIGIHTGKILGGILGTNIVRYDIFGKDVMIANKVESNGVGGQISVSEATKVL 2416
Query: 470 LGDDYKVEPGHGGYRNAYLK--DHNIETYLI 498
L ++YK + LK + I+TYL+
Sbjct: 2417 LENNYKDIFQFKDHNPIKLKNFEEEIKTYLV 2447
Score = 40.7 bits (91), Expect = 0.10
Identities = 37/156 (23%), Positives = 68/156 (43%), Gaps = 15/156 (9%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+I+F +I F + + E + L+ L+ FD + + +I+ +G Y SGL
Sbjct: 1584 VAIVFVEIVSFDEILKE-QDENFIHWLDNLYRSFDYVCQRYGVQKIETVGKVYMACSGLD 1642
Query: 384 EARDDHAKCC---------VEMGLDMIDAIALVREVM-----AVNVNMRVGIHTGRVHCV 429
A+ AK + LD AI + + + +++GIH GRV
Sbjct: 1643 VAKHQKAKKGNDRIWRENETKKALDAAFAIQKKAQKIYWGSKSQKTTLKIGIHYGRVIAG 1702
Query: 430 VLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V+G K QF + + V + + S A + ++++
Sbjct: 1703 VIGYHKPQFSLIGDTVNTTSRVCSHCEANNITLSQQ 1738
>UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1;
Pseudoalteromonas atlantica T6c|Rep: Adenylate/guanylate
cyclase - Pseudoalteromonas atlantica (strain T6c /
BAA-1087)
Length = 407
Score = 105 bits (253), Expect = 2e-21
Identities = 55/159 (34%), Positives = 88/159 (55%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
+Y+ VSI F D+ F+ L A+ LV LL+++F++FDRL+ H +IK +GD Y
Sbjct: 227 QYDQVSICFLDLENFSLLVKTLKAQALVDLLDDVFSQFDRLSEHHGLEKIKTIGDGYMAA 286
Query: 380 SGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFD 439
+G+P+ + HA C L + DA + ++ + +R+GI +G V V+G K+ +D
Sbjct: 287 AGVPDINNAHAVQCCAYALAVKDAFSALQHKYHLTTGLRIGIGSGEVVAGVIGRSKFCYD 346
Query: 440 VWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
+W VTLA MES G ++ +T+ T Y EP
Sbjct: 347 LWGEAVTLAARMESHGRTDQIQVTQSTYEMAKHKYCFEP 385
>UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29;
n=1; Caenorhabditis elegans|Rep: Putative uncharacterized
protein gcy-29 - Caenorhabditis elegans
Length = 1034
Score = 105 bits (253), Expect = 2e-21
Identities = 67/222 (30%), Positives = 113/222 (50%), Gaps = 13/222 (5%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+HVA+E+KA P+ Y++ +++F+DI GFT L T E+V LL
Sbjct: 817 LLPKHVAIELKAGRTVAPK----------MYDSATVMFSDIVGFTKLCSASTPIEVVNLL 866
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP-EARDDHAKCCVEMGLDMIDAIAL--V 407
N+L++ FD + ++H C +++ +GD Y VSG+P E H + L ++D + + V
Sbjct: 867 NKLYSEFDTVISKHDCYKVETIGDAYMVVSGIPIENGQRHVANISAVTLGIMDLLKVFEV 926
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ +R+G +G+V V+GL ++ ++ V +A MES G GRV IT+ +
Sbjct: 927 PHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRVQITETSK 986
Query: 468 CCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
L ++Y N +K + TY + D KK
Sbjct: 987 ILLENEYPEFIIEIRGINKDVKQDDFVTYWLTGKDEDYFKKK 1028
>UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to
ENSANGP00000014144; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000014144 - Nasonia
vitripennis
Length = 1648
Score = 105 bits (252), Expect = 3e-21
Identities = 63/179 (35%), Positives = 103/179 (57%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
VLPR VA ++ A QP EQF E V+I F+DI GFT+L + T E+V L
Sbjct: 1395 VLPRQVACQLMAGEMVQP--EQF--------ECVTIYFSDIVGFTALCAKSTPMEVVDFL 1444
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIA--LV 407
N+L++ FDR+ + +++ +GD Y VSGLPE D+H+K M L ++DA+ +
Sbjct: 1445 NDLYSTFDRIIGFYDVYKVETIGDAYMVVSGLPERNGDEHSKEIALMALAILDAVKSFTI 1504
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+++R+G+H+G V V+G + + ++ + V A+ MES G+ R+H+++ T
Sbjct: 1505 IHKQDAQLSVRIGVHSGPVCAGVVGQKMPHYCLFGDTVNTASRMESSGLPLRIHVSRAT 1563
>UniRef50_UPI00006CEB6E Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2842
Score = 104 bits (250), Expect = 5e-21
Identities = 59/149 (39%), Positives = 91/149 (61%), Gaps = 4/149 (2%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS- 380
+NV+ILFADI FT S Q E++V++L LF FDR + ++ +GDCY +S
Sbjct: 2642 DNVTILFADISQFTKYSSQVQPEQVVKMLRSLFYEFDRSVQYLNLFKLYTIGDCYVVLSF 2701
Query: 381 GLPEARD--DHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVLGLRKWQ 437
R+ + AK + MGL+MI I VR ++ ++MR+G+HTGR+ V+G +
Sbjct: 2702 NDINKRNIVEEAKNVIYMGLEMIRIIRNVRSIINFEELDMRIGVHTGRIIGGVIGTDIVR 2761
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET 466
+DV+ +DVT+AN MES G G++ I++ T
Sbjct: 2762 YDVYGSDVTIANKMESNGERGKILISQVT 2790
Score = 70.1 bits (164), Expect = 1e-10
Identities = 70/309 (22%), Positives = 133/309 (43%), Gaps = 15/309 (4%)
Query: 169 LLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLD 228
L+I+ F L S T +++Y + + H IG + + I +
Sbjct: 1715 LVIQILFKIIQDLVSFTNLMLVSIIYSYNMNFAIIAKPHLICIGSVMQNIIFIPLMIAQT 1774
Query: 229 NSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLET-RDCVEAXXXXXXXXXXXXXX 287
+SS + +I LI C +L L Q+ +T R+
Sbjct: 1775 SSSQSESSVSIYVLI-CAVIYILNFMVTLLIQKYTLEQTERNNFLQFSKMQQETQKVNNV 1833
Query: 288 XXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELV 347
+LP+ V + A+ S E ++I + E V++LF IC F +S Q E++V
Sbjct: 1834 LSILLPKFVRERISAEQLSNENTESRNQISEDQGE-VAVLFLLICDFDEIS-QSENEKIV 1891
Query: 348 RLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHA----------KCCVEMG 397
LL+ LF FD L + + +I+ +G+ Y C +GL + ++ + + +
Sbjct: 1892 MLLDNLFRYFDNLCSANDVTKIETVGNSYVCAAGLKSVEEQNSRKKANAINPVRRMINLA 1951
Query: 398 LDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
DM + + ++ ++ +++GIH G+V V+G K QF + + V + + S G
Sbjct: 1952 FDMKNYVQNIKWGSQGQSMVIKIGIHYGKVMAGVIGYHKPQFSLIGDTVNTTSRVMSTGE 2011
Query: 457 AGRVHITKE 465
G++ ++K+
Sbjct: 2012 NGKITLSKQ 2020
>UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2703
Score = 104 bits (250), Expect = 5e-21
Identities = 60/186 (32%), Positives = 100/186 (53%), Gaps = 5/186 (2%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
I ++++ +ILFADI GFT SDQ E +V++L +F FD+ H ++ +GDC
Sbjct: 2511 IIAEKFDKQTILFADIAGFTRYSDQNQPETVVKMLRTIFTEFDQKCQYHKVFKVYTIGDC 2570
Query: 376 YYCVSGL-PEARD--DHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y + E RD A + M MI+ + E++ ++MR+G+HTG++ ++G
Sbjct: 2571 YVILGNTNHENRDPPTEAYNVIMMAFQMIEILKRTTELVENQIDMRIGVHTGKIVGGLVG 2630
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLK--D 490
+ ++D++ DV +AN MES G G V +++ T L + Y E + Y+K D
Sbjct: 2631 TQIVRYDIYGVDVMIANKMESNGQKGSVVVSETTKDILQERYGKEFIFTEKGDVYIKATD 2690
Query: 491 HNIETY 496
NI T+
Sbjct: 2691 TNIRTF 2696
Score = 53.6 bits (123), Expect = 1e-05
Identities = 41/163 (25%), Positives = 79/163 (48%), Gaps = 20/163 (12%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGL 382
NV++LF DI F + Q E++V++L+ LF +FD+ + L+I+ +G Y +GL
Sbjct: 1843 NVAVLFCDITNFDEIMMQ-EEEKIVKVLDNLFRQFDKSCQANQVLKIETVGKTYMAAAGL 1901
Query: 383 PEARD-------------DHAKCCVEMGLDMIDAIALVREVMAVN------VNMRVGIHT 423
+ + D K C+++ ++M + + N V +++GI+
Sbjct: 1902 RDVDEYYQDGQNQVNTFVDPVKRCLQVAMEMQEIAKNITWGNTNNGGKSGKVEIKIGINY 1961
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G V V+G K QF + + V A+ + S G+ ++I+ +
Sbjct: 1962 GTVISGVIGFHKPQFSLIGDTVNTASRVCSTGLPKTINISNSS 2004
>UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2982
Score = 104 bits (250), Expect = 5e-21
Identities = 58/159 (36%), Positives = 90/159 (56%), Gaps = 6/159 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+E ++LFADI FT EE+V +L+ LF +FD E C ++ +GDC Y V
Sbjct: 2719 FEEATLLFADITDFTKYCSMRNPEEVVNMLSNLFLKFDMKCQELKCFKVYTIGDC-YVVL 2777
Query: 381 GLPEARD----DHAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRK 435
G+ A++ A V+MGL+M++ I VR EV +NMR+GIHTG++ + G
Sbjct: 2778 GVDNAKERNPAKEANNVVQMGLNMLEIIKQVRSEVNFETLNMRIGIHTGQIIGGITGSDI 2837
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDY 474
++D++ DV L+N MES G G++ +++ T L Y
Sbjct: 2838 VRYDIYGTDVMLSNKMESNGEPGKIMVSQTTKDLLESAY 2876
Score = 60.1 bits (139), Expect = 2e-07
Identities = 44/185 (23%), Positives = 89/185 (48%), Gaps = 17/185 (9%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ + +K++ ++P Q ++ SI+F DIC F + + E+++ L
Sbjct: 1864 LLPKFIINRIKSNDPNKPFRFQ------EKQGEASIIFCDICHFDDIIKEKN-EKIIPFL 1916
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD---------DHAKCCVEMGLDMI 401
+++F FD+ A +I+ +G Y +GL + D D + + L+M+
Sbjct: 1917 DKVFKNFDQFCARQGLQKIETVGKTYMASAGLKDFEDQVDIRQREIDPVERAANLALEML 1976
Query: 402 DAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
D + ++ N+ +++GIH G+V V+G K QF + + V + + S G V
Sbjct: 1977 DYVKDLKWSQNGKNLELKIGIHYGQVIAGVIGHHKPQFSLIGDTVNTTSRVCSKGNPSEV 2036
Query: 461 HITKE 465
I+++
Sbjct: 2037 TISEQ 2041
>UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1154
Score = 104 bits (250), Expect = 5e-21
Identities = 68/215 (31%), Positives = 115/215 (53%), Gaps = 16/215 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA +K QP H Y ++ F+DI GFT++S E+V LL
Sbjct: 920 LLPKSVAQALKKGRPVQPEH----------YSESTLYFSDIVGFTTISALSEPIEVVDLL 969
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--V 407
N+L+ FD + A H +++ +GD Y SG+P + HA M LD++ +IA +
Sbjct: 970 NDLYTMFDAIIATHDVYKVETIGDAYMVASGVPNRNGNRHAAEVANMSLDILHSIAAFKI 1029
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ + + V +R+G+H+G V V+GL ++ ++ + VT A++ME+ G+ R+HI+ T+
Sbjct: 1030 KHMPEIKVKIRIGLHSGPVVAGVVGLTMPRYCLFGDTVTTASHMEASGLPYRIHISLSTV 1089
Query: 468 CCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDD 502
L K+ H R A +K ++TY +V D
Sbjct: 1090 KVL-TSLKL-GYHMETRKAQVKG-AVDTYWLVGRD 1121
>UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 362
Score = 104 bits (250), Expect = 5e-21
Identities = 69/214 (32%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP+ +A E+KA P+ YE ++LF D GFTS++ + +L++
Sbjct: 137 NILPKEIAEELKAKGTVAPKP----------YELATVLFTDFKGFTSVAARMKPIDLLKE 186
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN F FD + +H RIK +GD Y CV G+P A + V L+M + RE
Sbjct: 187 LNACFDAFDEIIEKHEMERIKTIGDAYMCVGGVPNANTTNPVNAVLAALEMQRFMKQKRE 246
Query: 410 VMAVN----VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
A R+GI++G V V+G +K+ +D+W + V A+ MES G AG+V+I+
Sbjct: 247 EKASQGENYWQCRLGINSGEVIAGVIGRKKFAYDIWGDTVNSASRMESNGEAGKVNISGS 306
Query: 466 TLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
T + D ++ E H G NA K ++ Y ++
Sbjct: 307 THALVKDLFECE--HRGKINAKGKG-EVDMYFVL 337
>UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1;
Chlamydomonas reinhardtii|Rep: Soluble guanylyl cyclase
beta - Chlamydomonas reinhardtii
Length = 991
Score = 104 bits (250), Expect = 5e-21
Identities = 64/200 (32%), Positives = 109/200 (54%), Gaps = 6/200 (3%)
Query: 303 DIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
++AS ++E+ + Q + ++LF+DI GFT ++ + + E+ LL+EL+ RFD
Sbjct: 457 EVASCLKNEE--RAPAQEHPEATVLFSDIVGFTEIASRSSPLEVCSLLDELYQRFDAAIE 514
Query: 363 EHHCL-RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGI 421
E+ L +++ +GD Y V + DDHA +E L M + + V + V +RVG+
Sbjct: 515 EYPQLYKVETIGDAYMVVCNVTVPCDDHADVLLEFALRMHEEASRVASSLGEPVRIRVGM 574
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHG 481
H+G V V+G + +F ++ + V A+ MES G AG++HI++ CCL + E
Sbjct: 575 HSGPVVAGVVGRKMPRFCLFGDTVNTASRMESHGEAGQIHISEACYCCLRSKERFEIRER 634
Query: 482 GYRNAYLKDH-NIETYLIVP 500
G N +K + TYL+ P
Sbjct: 635 G--NITVKGKGTMRTYLLSP 652
>UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Paramecium
tetraurelia|Rep: Guanylyl cyclase, putative - Paramecium
tetraurelia
Length = 2634
Score = 104 bits (250), Expect = 5e-21
Identities = 67/203 (33%), Positives = 105/203 (51%), Gaps = 10/203 (4%)
Query: 307 QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC 366
QP ++ + +I ++ ++LFADI GFT S E +V +L LF FD
Sbjct: 2428 QPESDKT-ETFIDVLDHATVLFADIAGFTKYSSSVQPETVVEMLRNLFQSFDLYCQMAQI 2486
Query: 367 LRIKLLGDCYYCVSGLPEARDD---HAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIH 422
++ +GDCY C+ L + D A+ + GL MI I +++ ++NMR+G+H
Sbjct: 2487 YKLFTIGDCYVCMGVLDYTKRDPAEEAQKVLAFGLKMIQIINDIKQDPQYQHLNMRIGVH 2546
Query: 423 TGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHI---TKETLCCLGDDYKVEPG 479
TGRV V+G ++D++ DVT+AN MES G G++ I TK + DD+K E
Sbjct: 2547 TGRVLGGVVGTDVVRYDIYGEDVTIANLMESSGTEGKMLISDYTKNLVESEYDDFKFEYA 2606
Query: 480 HGGYRNAYLKDHNIETYLIVPDD 502
Y + KD I T+ + +D
Sbjct: 2607 KDVYIQS--KDMTIPTFFVSLND 2627
Score = 59.3 bits (137), Expect = 3e-07
Identities = 44/171 (25%), Positives = 84/171 (49%), Gaps = 9/171 (5%)
Query: 315 KIYIQRYE-NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLG 373
+I IQ+ + +V+ILF DI F + + E ++ L+ L+ FD+L + +I+ +G
Sbjct: 1641 QIQIQQDQGDVTILFCDIYQFDKVI-KYEQENILNFLDTLYRAFDQLCQTYDLQKIETVG 1699
Query: 374 DCYYCVSGLPE-------ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRV 426
Y GL + + +E + M+DA+ ++ +V +++GIH GRV
Sbjct: 1700 KTYMAAGGLKDYDAVINQKNANSTTRALETAIAMMDAVKTMKYGDNQDVKLKIGIHYGRV 1759
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
V+G+ K QF + + V + + S G AG + +++ + D K +
Sbjct: 1760 IAGVIGVHKPQFSLIGDTVNTTSRVCSTGDAGFITLSESAYNNIKDTTKYQ 1810
>UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta 2 subunit; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta 2 subunit - Strongylocentrotus purpuratus
Length = 645
Score = 104 bits (249), Expect = 7e-21
Identities = 52/153 (33%), Positives = 88/153 (57%), Gaps = 1/153 (0%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
K+ ++ V+I F+DI FT + QC ++V LLNE++ FD L + H+ +++ +GD
Sbjct: 491 KVEAGEFQQVTISFSDIVRFTDMCSQCDPIQIVYLLNEMYVVFDELTSVHNVYKVETIGD 550
Query: 375 CYYCVSGLPEARDDHAKCCVEMGLDMIDAI-ALVREVMAVNVNMRVGIHTGRVHCVVLGL 433
Y V GLP + HA+ GL ++ + ++ V + +RVGIHTG V V+G+
Sbjct: 551 AYMTVGGLPIPNETHAEQVACFGLGQVEGVKSISSPVTGEIIQIRVGIHTGPVVAGVVGV 610
Query: 434 RKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ ++ ++ + V A+ MES V G+VHI+ T
Sbjct: 611 KMPRYCLFGDTVNTASRMESHSVPGKVHISPST 643
>UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_150, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2413
Score = 104 bits (249), Expect = 7e-21
Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 7/165 (4%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R + ++ ++ + V++LFADI GFT S E++V +L LF FD+ H+ +
Sbjct: 2213 RPNEEKRVLREQADEVTLLFADIAGFTEYSSSVQPEQVVNMLRNLFTEFDKNCLLHNVFK 2272
Query: 369 IKLLGDCYYCV------SGLPEARDDHAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGI 421
+ +GDCY + G+ A V MG MIDAI VR + ++MR+G+
Sbjct: 2273 LYTIGDCYVVMGMVDYGKGIQRNPSQEAVNVVRMGFAMIDAIRRVRAHINHPTLDMRIGV 2332
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
HTG + VLG ++D++ DV +AN MES G G V +++ET
Sbjct: 2333 HTGSIIGGVLGTELVRYDIYGPDVLIANKMESKGAKGFVQVSQET 2377
Score = 54.8 bits (126), Expect = 6e-06
Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 11/130 (8%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V++LF DI F L +V +L++LF RFD L +H +I+ +G Y +GL
Sbjct: 1635 VAVLFCDIIDFDQLIKN-EQSNVVDILDKLFRRFDLLCQQHEVQKIETVGKTYMAAAGLK 1693
Query: 384 ---EARDDHAKCCVEMGLDMIDAIALVREVMAVNV-NMRVGIHTGRVHCVVLGLRKWQFD 439
+ + + + LDM R VM+ V +++GIH G V V+G K QF
Sbjct: 1694 IHMSQKSNPVNKVISLALDM------KRHVMSNEVFQIKIGIHYGNVIAGVIGHHKPQFS 1747
Query: 440 VWSNDVTLAN 449
+ + + A+
Sbjct: 1748 LIGDTINTAS 1757
>UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha-3;
n=12; Amniota|Rep: Guanylate cyclase soluble subunit
alpha-3 - Homo sapiens (Human)
Length = 690
Score = 104 bits (249), Expect = 7e-21
Identities = 50/157 (31%), Positives = 90/157 (57%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL + D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
>UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1272
Score = 103 bits (248), Expect = 1e-20
Identities = 54/151 (35%), Positives = 89/151 (58%), Gaps = 3/151 (1%)
Query: 314 HKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLG 373
HK+ + YE VSI F+DI GFT++S +CT ++V LN+L+ FD + + +++ +G
Sbjct: 933 HKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIG 992
Query: 374 DCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVV 430
D Y VSGLP D HA M L ++ A++ +R + +R+GIH+G V V
Sbjct: 993 DAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGV 1052
Query: 431 LGLRKWQFDVWSNDVTLANYMESGGVAGRVH 461
+GL+ ++ ++ + V A+ MES GV ++H
Sbjct: 1053 VGLKMPRYCLFGDTVNTASRMESSGVPLKIH 1083
>UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Paramecium
tetraurelia|Rep: Cation-transporting ATPase - Paramecium
tetraurelia
Length = 2285
Score = 103 bits (248), Expect = 1e-20
Identities = 65/181 (35%), Positives = 102/181 (56%), Gaps = 12/181 (6%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP H ++MK + R E +I ++V++LFADI GFT S T E +V +L
Sbjct: 2048 LLPTHSYLKMKNNTLYN-RSE-----FIDDLDDVTLLFADIKGFTEYSHTQTPEGVVTML 2101
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD----DHAKCCVEMGLDMIDAIAL 406
LF FD+L +++ ++ +GDC Y V G +A A V+MG MI+ I
Sbjct: 2102 RNLFTEFDKLCLQYNVYKMYTIGDC-YVVMGFQQATKRNPIQEAINTVKMGFSMIEIIME 2160
Query: 407 VREVMAVN-VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
VR+++ +NMR+GIHTG + ++G ++D++ DV++AN MES G G V I++
Sbjct: 2161 VRKLIDFPLLNMRIGIHTGSIIGGIIGTDIVRYDIYGQDVSIANKMESSGSEGHVQISET 2220
Query: 466 T 466
T
Sbjct: 2221 T 2221
Score = 64.5 bits (150), Expect = 7e-09
Identities = 44/164 (26%), Positives = 78/164 (47%), Gaps = 11/164 (6%)
Query: 312 QFHKIYIQRYEN-VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
Q +++Q +N VSILF +C F S+ + +V +L+ LF FD L +H +I+
Sbjct: 1517 QLGSLHMQEAQNDVSILFCYVCDFDSIMKE-EGRNVVLMLDSLFRIFDNLCLQHGVQKIE 1575
Query: 371 LLGDCYYCVSGLPEA---------RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGI 421
+G Y +G+ + + + V M DM++ I + + M++GI
Sbjct: 1576 TVGYTYMAATGIKASEINISPHMLKTEKTMRLVNMAFDMMEQIQGRQYGKGNQIEMKIGI 1635
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
H GRV ++G K QF + + V + + S G G + ++ E
Sbjct: 1636 HVGRVIAGLIGHHKPQFSLIGDPVNQTSRVGSTGDVGAITLSAE 1679
>UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 975
Score = 103 bits (247), Expect = 1e-20
Identities = 61/192 (31%), Positives = 106/192 (55%), Gaps = 14/192 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP VA ++K +A P + + +V+I F+DI GFT+++ C+ ++V LL
Sbjct: 380 MLPSSVAEKLKMGLAVDP----------EEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLL 429
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIAL--VR 408
N+L+ FD ++ +++ +GD Y VSGLP DHA+ M LD++ V+
Sbjct: 430 NDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVK 489
Query: 409 EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLC 468
+ V + +R+G+HTG V+GL ++ ++ + V A+ MES G + R+H+++ET
Sbjct: 490 HLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRD 549
Query: 469 CLG--DDYKVEP 478
L Y +EP
Sbjct: 550 RLDARGGYAIEP 561
>UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1151
Score = 103 bits (246), Expect = 2e-20
Identities = 57/176 (32%), Positives = 98/176 (55%), Gaps = 13/176 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LPR VA ++K + +P + ++ +I F+D+ FT+L+ +C+ ++V LL
Sbjct: 927 MLPRQVADKLKIGESVEP----------ESFQMATIFFSDVVSFTTLAGKCSPLQVVNLL 976
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIALVR- 408
N LF FD + H C +++ +GD Y SG+P+ D HAK E+ + ++ R
Sbjct: 977 NGLFTAFDGIIDTHDCYKVETIGDGYLVCSGIPKRNGDQHAKEIAELSFAFLRTVSSFRV 1036
Query: 409 -EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
+ + VN+R+G H+G V+GL ++ ++ + V A+ MES G AGRVHI+
Sbjct: 1037 DHLPSERVNLRIGFHSGPAVAGVVGLTMPRYCLFGDSVNTASRMESNGKAGRVHIS 1092
>UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1111
Score = 102 bits (245), Expect = 2e-20
Identities = 49/150 (32%), Positives = 90/150 (60%), Gaps = 3/150 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E V+I F+D+ FT+L+ +CT ++V LLN+L+ FD + +H +++ +GD Y C
Sbjct: 890 ETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLC 949
Query: 379 VSGLPEAR-DDHAKCCVEMGLDMIDAIALVR--EVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP ++H + M L + ++ R + + +N+R+G++ G V V+GL
Sbjct: 950 VSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTM 1009
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+F ++ + V A+ MES G G++H++ E
Sbjct: 1010 PRFCLFGDAVNTASRMESNGKPGKIHVSAE 1039
>UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1170
Score = 102 bits (245), Expect = 2e-20
Identities = 49/150 (32%), Positives = 91/150 (60%), Gaps = 3/150 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E V+I F+D+ FT+L+ +CT ++V LLN+L+ FD + ++ +++ +GD Y C
Sbjct: 928 ETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLC 987
Query: 379 VSGLPEAR-DDHAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP ++H + M L + ++ V+ + + +N+R+GI+ G V V+GL
Sbjct: 988 VSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTM 1047
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
++ ++ + V A+ MES G G++H+T E
Sbjct: 1048 PRYCLFGDAVNTASRMESNGKPGKIHVTAE 1077
>UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit;
n=5; Percomorpha|Rep: Soluble guanylyl cyclase alpha2
subunit - Oryzias latipes (Medaka fish) (Japanese
ricefish)
Length = 805
Score = 102 bits (244), Expect = 3e-20
Identities = 52/155 (33%), Positives = 89/155 (57%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+++++V++LF+DI GFT++ CT +++ +LNEL+ RFD +I+ +GD Y
Sbjct: 584 RKFDDVTMLFSDIVGFTAVCAHCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCV 643
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
GL + D HAK M L M++ V + +R+GIHTG V V+G++ ++
Sbjct: 644 AGGLHKKVDSHAKPIAHMALKMMELSEEVLTPDGKPIKLRIGIHTGSVLAGVVGVKMPRY 703
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
++ N+VTLA+ ESG ++++ T L DD
Sbjct: 704 CLFGNNVTLASKFESGSHPRCINVSPTTYQLLKDD 738
>UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA -
Drosophila melanogaster (Fruit fly)
Length = 787
Score = 102 bits (244), Expect = 3e-20
Identities = 68/191 (35%), Positives = 112/191 (58%), Gaps = 22/191 (11%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGF----TSLSDQCTAEE 345
SVLP+ VA E+ RH++ + +RY++V+++F+ I GF + +D A +
Sbjct: 506 SVLPKSVANEL--------RHQR--PVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMK 555
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMID 402
+V++LNEL+ FD L L +++ +GD Y VSGLP+ +DHAKC + LDM+D
Sbjct: 556 IVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMD 615
Query: 403 AIALVREVMAVN-VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVH 461
V+ M N V + +GIH+G V V+G R ++ ++ N V L + E+ GV GR++
Sbjct: 616 MAKNVK--MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRIN 673
Query: 462 ITKET--LCCL 470
+++ET L C+
Sbjct: 674 VSEETYRLLCM 684
>UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, whole
genome shotgun sequence; n=5; Alveolata|Rep: Chromosome
undetermined scaffold_66, whole genome shotgun sequence -
Paramecium tetraurelia
Length = 2408
Score = 102 bits (244), Expect = 3e-20
Identities = 52/151 (34%), Positives = 86/151 (56%), Gaps = 4/151 (2%)
Query: 320 RYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCV 379
+ ++++ILFADI GFT S + EE++ +L LF FDR + + ++ +GDCY +
Sbjct: 2209 KIDDLTILFADIAGFTEYSSKVNPEEVLVMLKNLFVEFDRKCCDLNVYKLYTIGDCYVAI 2268
Query: 380 SGLP---EARDDHAKCCVEMGLDMIDAIALVR-EVMAVNVNMRVGIHTGRVHCVVLGLRK 435
+ AK +++ +MI I VR ++ +NMR+G+HTG V V+G
Sbjct: 2269 GMIDYHNRNPQQEAKNIIDLAFEMIKIITQVRKQINFEGLNMRIGVHTGPVFGGVMGTDI 2328
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++D++ DV +AN MES GV G V +++ T
Sbjct: 2329 VRYDIYGPDVLIANKMESNGVKGNVQVSQST 2359
Score = 43.6 bits (98), Expect = 0.014
Identities = 32/151 (21%), Positives = 71/151 (47%), Gaps = 10/151 (6%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+I+F DIC F + + ++++ L+++F FD+ + +I+ +G Y +GL
Sbjct: 1631 VAIVFCDICNFDQMVTE-EKDKIITFLDDIFRTFDKYCQIYGVQKIETVGKTYLASAGLK 1689
Query: 384 EARDDHAKCC----VEMGLDMIDAIAL-VREVM----AVNVNMRVGIHTGRVHCVVLGLR 434
+ V+ L++ + + + +R M + ++GIH G V+G
Sbjct: 1690 ACEQELTYLSQVDPVQRALNLAEQMMIYIRSKMWGYKGQQLVGKIGIHYGGAISGVIGFH 1749
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
K QF + + V + + S G+ + ++++
Sbjct: 1750 KPQFSLIGDTVNTTSRICSTGLEDAITLSEQ 1780
>UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic
peptide receptor A - Strongylocentrotus purpuratus
Length = 853
Score = 101 bits (243), Expect = 4e-20
Identities = 60/178 (33%), Positives = 99/178 (55%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
VLPR VA ++K + P + YENV+I F+DI GFT++S + T ++V LL
Sbjct: 642 VLPRSVAEQLKLGKSVDP----------ESYENVTIFFSDIVGFTAISSESTPLQVVALL 691
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD-DHAKCCVEMGLDMIDAIA--LV 407
N+L+ FD + A +++ +GD Y VSGLP HA+ EM L +++A+ +
Sbjct: 692 NDLYICFDGIIANSDVYKVETIGDAYMVVSGLPIRNGITHAREIAEMSLSLLEAVKSFKI 751
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
R + +R GIH+G V+GL+ ++ ++ + V A+ MES G A ++H + +
Sbjct: 752 RHRPDEQLKLRAGIHSGPCVAGVIGLKMPRYCLFGDTVNTASRMESNGEAMKIHASSD 809
>UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subunit
beta-2 (EC 4.6.1.2) (GCS-beta-2).; n=2; Gallus
gallus|Rep: Guanylate cyclase soluble subunit beta-2 (EC
4.6.1.2) (GCS-beta-2). - Gallus gallus
Length = 659
Score = 101 bits (243), Expect = 4e-20
Identities = 55/182 (30%), Positives = 101/182 (55%), Gaps = 11/182 (6%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP+HVA ++K + ++ ++ +ILF+D+ FT++ QC ++V +
Sbjct: 447 AMLPQHVANQLK----------EGKRVEAGEFKECTILFSDVVTFTNICAQCEPIQIVLM 496
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LN ++ +FDRL H +++ +GD Y V G+P HA+ L +I A V+
Sbjct: 497 LNSMYLQFDRLTTVHDVYKVETIGDAYMVVGGVPVPVSTHAERIANFALGIIIAAKGVQN 556
Query: 410 VMAVN-VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLC 468
++ N + +RVGIHTG V V+G + ++ ++ + V +A+ MES GV ++H++
Sbjct: 557 PVSGNPIQIRVGIHTGPVLAGVVGEKMPRYCLFGDTVNIASRMESHGVPSKIHLSSSAYQ 616
Query: 469 CL 470
CL
Sbjct: 617 CL 618
>UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulator;
n=1; Microscilla marina ATCC 23134|Rep: Two-component
hybrid sensor and regulator - Microscilla marina ATCC
23134
Length = 1269
Score = 101 bits (242), Expect = 5e-20
Identities = 67/210 (31%), Positives = 107/210 (50%), Gaps = 11/210 (5%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
K ++ Y ++LF D GFT + + ++ELV LNE FA FD + +++ +IK +GD
Sbjct: 1059 KAPVKYYAMSTVLFTDFQGFTKQASEMDSKELVEDLNEYFAGFDDIMEQYNLEKIKTIGD 1118
Query: 375 CYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN----VNMRVGIHTGRVHCVV 430
Y G+P++ + V GL + +A R ++R+G++TG V V
Sbjct: 1119 AYMAAGGIPQSNTTNPVDAVLAGLAIQQFVAAKRAERKAEGKQFWDVRLGVNTGEVIAGV 1178
Query: 431 LGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKD 490
+G +K+ +DVW + V A MESGG G V+I+ T + D + VE H G NA K
Sbjct: 1179 IGTKKFAYDVWGDSVNTAARMESGGKVGEVNISHNTYEMVKDYFDVE--HRGKVNAKGKG 1236
Query: 491 HNIETYLI--VPDDTSRVD--KKPQHSFAV 516
++ Y + + + S D KP +F V
Sbjct: 1237 -EVDMYFVKRIKSELSADDAGTKPNQAFWV 1265
>UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 3179
Score = 101 bits (242), Expect = 5e-20
Identities = 57/165 (34%), Positives = 93/165 (56%), Gaps = 11/165 (6%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R+ + + I+ +++ ++LFADI GFT+ S E++V +L LF +FD +H+ +
Sbjct: 2972 RNPEDNSIFTEKFTQTTLLFADISGFTAYSSNKKPEQVVHMLKSLFTKFDHKCIKHNVFK 3031
Query: 369 IKLLGDCYYCVSGLPEA--RDD--HAKCCVEMGLDMIDAIALVR------EVMAVNVNMR 418
+ +GDC Y V G +A RD AK +EMG MI+++ R +++MR
Sbjct: 3032 LYTIGDC-YIVMGFSDANKRDPPAEAKNVLEMGFSMIESLRQFRLEQKDPSDQNADIHMR 3090
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
+GIH G + V+G ++D++ DV LAN MES G GR+ I+
Sbjct: 3091 IGIHIGDIIGGVIGKNVVRYDIYGKDVLLANKMESNGERGRILIS 3135
Score = 50.4 bits (115), Expect = 1e-04
Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 10/147 (6%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
E SILF D+ F + D+ ++V LL+ LF FD L ++ +I+ +G Y G
Sbjct: 2228 EEASILFCDVSDFDKIMDR-EDYKIVSLLDNLFREFDELTFQYGLQKIETVGKTYMAAGG 2286
Query: 382 LPEARDDHAKCCVEMG--LDMIDAIALVREVMAVN-------VNMRVGIHTGRVHCVVLG 432
L + +K + + M+ + +V A + V +++G+H G + V+G
Sbjct: 2287 LKAVEKNLSKKITKSHHFIRMLIMSNKMHQVAAKSQWGDGYPVKLKIGVHIGPITAGVIG 2346
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGR 459
K QF + + V + + S GR
Sbjct: 2347 YHKPQFSLIGDTVNTTSRLCSNCEPGR 2373
>UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha-3;
n=16; Coelomata|Rep: Guanylate cyclase soluble subunit
alpha-3 - Mus musculus (Mouse)
Length = 691
Score = 101 bits (242), Expect = 5e-20
Identities = 49/157 (31%), Positives = 88/157 (56%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ V++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 472 VQAKKFSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 532 YCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
>UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-35 -
Caenorhabditis elegans
Length = 688
Score = 101 bits (242), Expect = 5e-20
Identities = 44/147 (29%), Positives = 91/147 (61%), Gaps = 1/147 (0%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ + + ++LF DI FT++ CT ++V LLN+L+ RFDRL H +++ +GD Y
Sbjct: 418 KEFADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMI 477
Query: 379 VSGLPEARDDHAKCCVEMGLDMI-DAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
V G+PE ++HA+ + + + M+ ++ ++ + + +R+G+H G V V+G++ +
Sbjct: 478 VGGVPERCENHAERVLNISIGMLMESKLVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPR 537
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITK 464
+ ++ + V +AN MES G+ ++H+++
Sbjct: 538 YCLFGDTVNVANKMESNGIQCKIHVSE 564
>UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n=1;
Methylobacterium sp. 4-46|Rep: Putative
adenylate/guanylate cyclase - Methylobacterium sp. 4-46
Length = 422
Score = 101 bits (241), Expect = 7e-20
Identities = 53/157 (33%), Positives = 86/157 (54%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
++V+I F DI GFT L+ + + +++RLLN+LF++ D +AA+H +IK +GD Y +G
Sbjct: 245 DHVTISFCDIVGFTHLASRTSPHDVIRLLNDLFSQLDDIAAKHGIEKIKTIGDAYMAAAG 304
Query: 382 LPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVW 441
+ +A A LD A+ E + MR GI TG+V V+G+ + FDVW
Sbjct: 305 VGDAIHKDAHAVAGFALDARRAVLETGERHGAAIQMRFGIATGQVISGVIGVTRPVFDVW 364
Query: 442 SNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
+ V LA+ +E+ G + + T L ++V P
Sbjct: 365 GSTVNLASRLETASPPGAITLDARTAELLDRRFRVRP 401
>UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 642
Score = 101 bits (241), Expect = 7e-20
Identities = 64/192 (33%), Positives = 101/192 (52%), Gaps = 14/192 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP VA E+K + K I+ +E VS+LF D GFT L++ +ELV+
Sbjct: 404 NILPEQVANELK----------EHGKAKIRHHEMVSVLFTDFKGFTKLAETMPPQELVQE 453
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM---IDAIAL 406
L + F FD + +H+ +IK +GD Y V GLP + V GL++ +D +
Sbjct: 454 LEKCFTLFDEIMEKHNLEKIKTIGDAYMAVGGLPVPNTTNFVDIVLAGLEIQRSMDQLKA 513
Query: 407 VREVMAVNV-NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+E R+GI+TG++ V+G K+ +DVW + V A+ MES G GRV+I+
Sbjct: 514 EKEAKGEPFWETRLGINTGKLIAGVIGKNKFAYDVWGDTVNTASRMESSGEIGRVNISGV 573
Query: 466 TLCCLGDDYKVE 477
T + D ++ E
Sbjct: 574 TYELVKDFFECE 585
>UniRef50_A0LXB4 Cluster: Secreted protein containing
adenylate/guanylate cyclase catalytic domain; n=1;
Gramella forsetii KT0803|Rep: Secreted protein
containing adenylate/guanylate cyclase catalytic domain
- Gramella forsetii (strain KT0803)
Length = 610
Score = 101 bits (241), Expect = 7e-20
Identities = 49/166 (29%), Positives = 94/166 (56%), Gaps = 3/166 (1%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
K+ +++E+V++LFAD FT +++ E L++ ++ F++FD++ ++ +IK +GD
Sbjct: 415 KVRAKKFESVTVLFADFKRFTLIAENLPPERLIKTIDYYFSQFDKIMEKYDIEKIKTIGD 474
Query: 375 CYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMA---VNVNMRVGIHTGRVHCVVL 431
Y SGLP DHA + +M + +E N ++RVG+++G V V+
Sbjct: 475 SYMAASGLPFPNQDHAYKILMAAFEMTQFVKETKENSLYDDANFDVRVGLNSGPVVAGVV 534
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
G +K+ +D+W + V +A MES G+++I++ T + D + E
Sbjct: 535 GTKKFAYDIWGDTVNIAARMESHSDIGKINISENTYDLIKDKFDCE 580
>UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7;
Endopterygota|Rep: CG3216-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1141
Score = 101 bits (241), Expect = 7e-20
Identities = 57/183 (31%), Positives = 101/183 (55%), Gaps = 13/183 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LPR VA ++ A +P + + +V+I F+DI GFT L + + ++V L
Sbjct: 910 ILPRPVAQQLMAGDLVEP----------EEFSSVTIYFSDIVGFTELCARSSPMDVVNFL 959
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIAL--V 407
N+L++ FDR+ + +++ +GD Y VSGLPE D HA+ M LD++ A++ +
Sbjct: 960 NDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNL 1019
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
R + +R+G+H+G V V+G + + ++ + V A+ MES G G++H++ T
Sbjct: 1020 RHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATK 1079
Query: 468 CCL 470
L
Sbjct: 1080 AIL 1082
>UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=5;
Pleocyemata|Rep: Guanylate cyclase PcGC-M2 precursor -
Procambarus clarkii (Red swamp crayfish)
Length = 1423
Score = 101 bits (241), Expect = 7e-20
Identities = 63/194 (32%), Positives = 106/194 (54%), Gaps = 16/194 (8%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP VA + IA +P Q +++V+I F+DI GFTSLS + T ++VR L
Sbjct: 973 MLPSSVAASLTQGIAVEP----------QGFDSVTIYFSDIVGFTSLSAESTPYQVVRFL 1022
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIA---L 406
N+L+ FD + + +++ +GD Y VSGLP+ HA M L+++D + +
Sbjct: 1023 NDLYTLFDNIIRGYDVYKVETIGDAYMVVSGLPKPNMGRHAGEIASMALELLDGVQNKFI 1082
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+R + +R+G+HTG V V+GL ++ ++ + V A+ MES G R+HI+++
Sbjct: 1083 IRHRPEKKLLLRIGLHTGPVIAGVVGLTMPRYCLFGDTVNTASRMESNGEPLRIHISEQC 1142
Query: 467 LCCLGD--DYKVEP 478
L + Y +EP
Sbjct: 1143 HIALKNLGGYVMEP 1156
>UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha-2;
n=39; Eumetazoa|Rep: Guanylate cyclase soluble subunit
alpha-2 - Homo sapiens (Human)
Length = 732
Score = 101 bits (241), Expect = 7e-20
Identities = 51/155 (32%), Positives = 90/155 (58%)
Query: 312 QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 371
Q ++ +++++V++LF+DI GFT++ QCT +++ +LNEL+ RFD +++
Sbjct: 508 QGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVET 567
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVL 431
+GD Y +GL HAK M L M++ V + MR+GIH+G V V+
Sbjct: 568 IGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G+R ++ ++ N+VTLA+ ESG R++++ T
Sbjct: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662
>UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2;
Caenorhabditis|Rep: Guanylyl cyclase protein 11 -
Caenorhabditis elegans
Length = 1032
Score = 100 bits (240), Expect = 9e-20
Identities = 61/178 (34%), Positives = 98/178 (55%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA +K QP +F Y++VSI F+DI GFT+LS + T ++V +L
Sbjct: 799 LLPKSVANSLKN---GQPVDAEF-------YDSVSIYFSDIVGFTALSSKSTPLQVVNML 848
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LV 407
N L+ FD + + C +++ +GD Y VSGLPE HA L+++D+I V
Sbjct: 849 NNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTV 908
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ +R+G HTG V V+G+R ++ ++ + V +AN MES G R+ I+ +
Sbjct: 909 SHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSD 966
>UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Plasmodium vivax|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Plasmodium vivax
Length = 3979
Score = 100 bits (240), Expect = 9e-20
Identities = 56/155 (36%), Positives = 91/155 (58%), Gaps = 10/155 (6%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ ++ LFADICGFTS ++ A E++ LL +LFA+FD + ++ ++ +GD Y +S
Sbjct: 3717 HDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVAIS 3776
Query: 381 GLPEARD-------DHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVLG 432
P D D + +EM MI I +RE + + N+NMR+G+H G V+G
Sbjct: 3777 E-PVTEDNQDYDPVDGTERVLEMAYSMIRIIKEIREKLCIPNLNMRIGLHYGSCVGGVIG 3835
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ ++D+W DV N MES GV G+++++ ETL
Sbjct: 3836 SGRLRYDLWGIDVLTGNLMESNGVPGKINVS-ETL 3869
Score = 41.9 bits (94), Expect = 0.044
Identities = 20/70 (28%), Positives = 35/70 (50%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
E V+I+F DI F ++ LV +L+ LF FD+ + +C +I+ + + Y G
Sbjct: 2829 ETVTIIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFETYLAACG 2888
Query: 382 LPEARDDHAK 391
L + +K
Sbjct: 2889 LVKKEGSESK 2898
Score = 39.1 bits (87), Expect = 0.31
Identities = 17/59 (28%), Positives = 37/59 (62%)
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
+ +++GI++GR+ V+G +K Q+ ++ + V A+ M++ G +HI++ T + DD
Sbjct: 2990 IRVKIGINSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYDLVKDD 3048
>UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_24, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2488
Score = 100 bits (240), Expect = 9e-20
Identities = 58/151 (38%), Positives = 87/151 (57%), Gaps = 6/151 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+EN +ILFADI GFT S E++V +L LF +FD + ++ +GDCY C+
Sbjct: 2294 FENCTILFADIAGFTKYSSSVEPEQVVNMLRILFQQFDEACQKFQVYKLYTIGDCYVCM- 2352
Query: 381 GLPEA--RD--DHAKCCVEMGLDMIDAIALV-REVMAVNVNMRVGIHTGRVHCVVLGLRK 435
G+ +A RD A V GL MI I + ++ ++NMR+G HTGRV V+G
Sbjct: 2353 GIIDANNRDPVGEAINVVLFGLKMIQIIQQINKDPQFQHLNMRIGAHTGRVIGGVVGTDV 2412
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++D++ DVT AN MES G G++ +++ T
Sbjct: 2413 VRYDIYGEDVTTANKMESKGQEGKIMVSQAT 2443
Score = 48.0 bits (109), Expect = 7e-04
Identities = 35/147 (23%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGL 382
+V+ILF DI F + ++V L+ L+ +FD+ + +I+ +G Y GL
Sbjct: 1571 DVAILFCDIYDFDDIIRN-EQIKVVEFLDNLYRQFDQFCQANELQKIETVGKTYMAAGGL 1629
Query: 383 PEAR-DDH---AKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
+ D+ + ++ L M +++ ++ V +++GIH GRV V+G K QF
Sbjct: 1630 KDYNMSDNLNPTERILDAALQMQESVKTMKYGDKKAVILKIGIHYGRVIAGVIGAHKPQF 1689
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKE 465
+ + V + + S G + ++++
Sbjct: 1690 SLIGDTVNTTSRVCSTSEPGIITLSQQ 1716
>UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_156, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2354
Score = 100 bits (240), Expect = 9e-20
Identities = 49/161 (30%), Positives = 94/161 (58%), Gaps = 4/161 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+EN +IL+ADI GFT S A++++++L+ LF +FD E++ ++ +GD Y +
Sbjct: 2166 FENATILYADIAGFTKYSTSVDAQQVLQMLSSLFNKFDVACTENNVYKLYSIGDSYVVIG 2225
Query: 381 GLPE---ARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIHTGRVHCVVLGLRKW 436
L R++ A V +G ++D + L+++ + ++NMR+GIHTG + ++G
Sbjct: 2226 VLDANNGIREEEAYNVVNLGFQLLDIVNLLKKNIQYPDINMRIGIHTGNIIGGIVGTDIV 2285
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
++D++ +DV +A ME GR+ ++++T+ L Y E
Sbjct: 2286 RYDIYGSDVAIAKKMEQNSQIGRIMVSEDTMKFLDATYTGE 2326
Score = 50.4 bits (115), Expect = 1e-04
Identities = 39/164 (23%), Positives = 80/164 (48%), Gaps = 13/164 (7%)
Query: 311 EQFHKIYIQRYEN---VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 367
E+ + YIQ E+ V+ILF +IC F + + ++ L+ ++ FD + +++
Sbjct: 1510 ERMARGYIQIQEDQGPVTILFCEICDFDDIIES-EKVSIISFLDSIYRTFDTICNQYNIQ 1568
Query: 368 RIKLLGDCYYCVSGLP--EARDDHAKCCVEMGLDMIDAIALVREVMAV-----NVNMRVG 420
+I+ +G Y C SGL + D +K + ++ AIA++ + + +++G
Sbjct: 1569 KIETVGQIYVCASGLKDYDIIDKQSKNSTQKMIEC--AIAMMESTNNLKYQDKQIVIKIG 1626
Query: 421 IHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITK 464
I+ G V V+G K QF + + V + + G++ +T+
Sbjct: 1627 INYGNVMAGVIGQHKPQFSLIGDTVNTTSRACTVCEPGKISLTE 1670
>UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep:
Guanylate cyclase - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 1176
Score = 99 bits (238), Expect = 2e-19
Identities = 60/193 (31%), Positives = 103/193 (53%), Gaps = 16/193 (8%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA+ +K +P H + V++ F+DI GFT++S E+V LL
Sbjct: 929 MLPKSVALALKTGKPVKPEH----------FAEVTLYFSDIVGFTTISALSEPIEVVDLL 978
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--V 407
N+L+ FD + A H +++ +GD Y SG+P HA M LD++ I +
Sbjct: 979 NDLYTHFDGIIAIHDVYKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKM 1038
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
R + V V +R+G+H+G V V+GL+ ++ ++ + V A+ MES G+ R+H+ + T+
Sbjct: 1039 RHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTV 1098
Query: 468 CCLGD---DYKVE 477
L YK++
Sbjct: 1099 DVLNSLKLGYKID 1111
>UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium
falciparum|Rep: Guanylyl cyclase - Plasmodium falciparum
Length = 4226
Score = 99.5 bits (237), Expect = 2e-19
Identities = 55/155 (35%), Positives = 91/155 (58%), Gaps = 10/155 (6%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ ++ LFADICGFTS ++ A E++ LL +LFA+FD + ++ ++ +GD Y +S
Sbjct: 3966 HDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVAIS 4025
Query: 381 GLPEARD-------DHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVLG 432
P D D + +EM MI I +RE + + N+NMR+G+H G V+G
Sbjct: 4026 E-PVTEDNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVIG 4084
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ ++D+W DV N MES G+ G+++++ ETL
Sbjct: 4085 SGRLRYDLWGIDVLTGNLMESNGIPGKINVS-ETL 4118
Score = 42.3 bits (95), Expect = 0.033
Identities = 19/59 (32%), Positives = 37/59 (62%)
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
+ ++VGIH+GR+ V+G +K Q+ ++ + V A+ M++ G +HI++ T + DD
Sbjct: 3233 IRVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDD 3291
Score = 37.9 bits (84), Expect = 0.71
Identities = 18/65 (27%), Positives = 32/65 (49%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+ +F DI F ++ LV +L+ LF FD+ + +C +I+ + + Y GL
Sbjct: 3012 VTTIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFETYLAACGLV 3071
Query: 384 EARDD 388
+ D
Sbjct: 3072 KREKD 3076
>UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus
japonicus|Rep: Guanylate cyclase - Stichopus japonicus
(Sea cucumber)
Length = 1075
Score = 99.5 bits (237), Expect = 2e-19
Identities = 58/176 (32%), Positives = 96/176 (54%), Gaps = 6/176 (3%)
Query: 297 AMEMKADIASQPRHEQFHK---IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNEL 353
A E+ I +P E+ K + + +E V+I F+DI GFT LS Q T ++V LLN+L
Sbjct: 849 AEELLYQILPKPVAEELKKGKPVTAETFEVVTIYFSDIVGFTKLSSQSTPLQVVDLLNDL 908
Query: 354 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--VREV 410
+ FD + + +++ +GD Y VSGLP D HA+ M L ++ I +R
Sbjct: 909 YTAFDAVIDNFNVYKVETIGDAYMVVSGLPIRNGDYHAREIARMSLALLQRIKTFRIRHR 968
Query: 411 MAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +R+GIH+G V+GL+ ++ ++ + V A+ MES G A ++H++ T
Sbjct: 969 SEERLKLRIGIHSGPAVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSST 1024
>UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylate
cyclase A; n=14; cellular organisms|Rep: Natriuretic
peptide receptor A/guanylate cyclase A - Homo sapiens
(Human)
Length = 255
Score = 99.5 bits (237), Expect = 2e-19
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 48 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 107
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 108 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 166
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 167 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 205
>UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A
precursor; n=57; Chordata|Rep: Atrial natriuretic peptide
receptor A precursor - Homo sapiens (Human)
Length = 1061
Score = 99.5 bits (237), Expect = 2e-19
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2815
Score = 99.1 bits (236), Expect = 3e-19
Identities = 54/163 (33%), Positives = 85/163 (52%), Gaps = 5/163 (3%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +V++LFADI GFT S +V +L LF FD + ++ +GDCY C
Sbjct: 2633 EELHDVTLLFADIAGFTKYSSTTDPIVVVNMLRRLFTDFDDHCLNQNVYKLYTIGDCYVC 2692
Query: 379 VSGLPEARD----DHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
GL + A V DMI I VR+ N+ MR+G+HTG+++ ++G
Sbjct: 2693 F-GLTNKNERNPAQEAHNVVRFAFDMIRIIENVRQYTDCNLQMRIGVHTGKLYGGIVGTE 2751
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
++D++ DV +AN MES G +G V +++ T L D++ E
Sbjct: 2752 IVRYDIYGQDVIIANKMESNGESGHVMVSETTKKLLEDNFPNE 2794
Score = 48.4 bits (110), Expect = 5e-04
Identities = 37/160 (23%), Positives = 74/160 (46%), Gaps = 14/160 (8%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
++ + V I+F DIC F + V++L++L+ +FD ++ +I+ +G Y
Sbjct: 1903 EKQDEVIIVFCDICNFDDIIFN-EKINTVKILDKLYRQFDLACQQNGLQKIETVGKTYLA 1961
Query: 379 VSGLPEARD-----------DHAKCCVEMGLDMIDAIALVREVMAVN--VNMRVGIHTGR 425
+G+ + AK ++ D+ + + +A N + ++VGIH G
Sbjct: 1962 AAGISDVEKLLKAEGRLQDVSPAKRALQFAFDLQRIVKSKQLYLASNKKIIIKVGIHLGP 2021
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V+G K QF + + V + + S G++ + I+KE
Sbjct: 2022 AISGVIGYHKPQFSLIGDTVNTTSRVCSTGLSDHIIISKE 2061
>UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n=23;
Eukaryota|Rep: Retinal guanylyl cyclase 1 precursor -
Homo sapiens (Human)
Length = 1103
Score = 99.1 bits (236), Expect = 3e-19
Identities = 55/163 (33%), Positives = 90/163 (55%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+E V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 876 FEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 935
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ A+ +R + V V +R+G+H+G V+GL +
Sbjct: 936 GLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 995
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET---LCCLGDDYKVE 477
+ ++ + V A+ MES G+ R+H+ T L L Y+VE
Sbjct: 996 YCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
>UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-2;
n=32; Euteleostomi|Rep: Guanylate cyclase soluble
subunit beta-2 - Homo sapiens (Human)
Length = 617
Score = 99.1 bits (236), Expect = 3e-19
Identities = 56/183 (30%), Positives = 100/183 (54%), Gaps = 10/183 (5%)
Query: 291 VLPRHVAMEMKAD----IASQPRH-----EQFHKIYIQRYENVSILFADICGFTSLSDQC 341
VL +H+A+E K A P+H + K+ +++ +ILF+D+ FT++ C
Sbjct: 348 VLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTAC 407
Query: 342 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM- 400
++V +LN ++++FDRL + H +++ +GD Y V G+P +HA+ L M
Sbjct: 408 EPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMR 467
Query: 401 IDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
I A + V + +RVGIHTG V V+G + ++ ++ + V A+ MES G+ +V
Sbjct: 468 ISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKV 527
Query: 461 HIT 463
H++
Sbjct: 528 HLS 530
>UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to
ENSANGP00000011644; n=3; Euteleostomi|Rep: PREDICTED:
similar to ENSANGP00000011644 - Danio rerio
Length = 584
Score = 98.7 bits (235), Expect = 4e-19
Identities = 54/162 (33%), Positives = 87/162 (53%), Gaps = 3/162 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ YE V+I F+DI GFT++S CT ++V +LN L+ FD + +++ +GD Y
Sbjct: 320 ESYEKVTIFFSDIVGFTAISASCTPLQVVEMLNNLYMCFDTRIDSYDVYKVETIGDAYMV 379
Query: 379 VSGLPEARDD-HAKCCVEMGLDMIDAIALV--REVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLPE D HA +M LD++ A+ V + + +R GIHTG V+G +
Sbjct: 380 VSGLPERNGDRHADEIAKMSLDLVAAVRQVPIPHMPTKRLQLRAGIHTGPCVAGVVGYKM 439
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
++ ++ + V A+ MES + ++H + T L D E
Sbjct: 440 PRYCLFGDTVNTASRMESTSLPQKIHASSATYLALMKDNAYE 481
>UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to
ENSANGP00000009149; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1319
Score = 98.7 bits (235), Expect = 4e-19
Identities = 53/151 (35%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E V+I F+DI GFTSLS + T E+V +LN+L+ FD + + + +++ +GD Y
Sbjct: 956 ESFECVTIFFSDIVGFTSLSSESTPFEVVDMLNDLYTLFDEIISYYDVYKVETIGDAYML 1015
Query: 379 VSGLPEARD-DHAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP + HA L +++ + VR VN+ +R+GIH+G V+GL
Sbjct: 1016 VSGLPLRNEKKHAAEIASTSLHLLEDVKAFKVRHRPEVNLKLRIGIHSGSTVSGVVGLTM 1075
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G A ++H + ET
Sbjct: 1076 PRYCLFGDTVNTASRMESNGEALKIHTSSET 1106
>UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta
proteobacterium MLMS-1|Rep: Guanylate cyclase - delta
proteobacterium MLMS-1
Length = 323
Score = 98.3 bits (234), Expect = 5e-19
Identities = 53/155 (34%), Positives = 87/155 (56%), Gaps = 5/155 (3%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCY 376
+ R + +ILF+D+ GFT L+++ ++ ELV +++++F FDR+ + + +IK +GD Y
Sbjct: 128 FAPRQYDCTILFSDVAGFTRLAEELSSVELVAIIDDIFRIFDRVVRDFNGTKIKTIGDAY 187
Query: 377 YCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE-----VMAVNVNMRVGIHTGRVHCVVL 431
V G P A +DH V L M + +A+ A R+GIH+G V V+
Sbjct: 188 MVVFGAPVADEDHPVRAVRAALAMQEGLAVFNRQRFGAATAQYFRCRIGIHSGPVTAGVV 247
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G + QFDV+ + V +A E+ G GRV+I+ T
Sbjct: 248 GEDRMQFDVFGDHVNIAARFETAGEPGRVNISAAT 282
>UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-1;
n=40; Coelomata|Rep: Guanylate cyclase soluble subunit
beta-1 - Homo sapiens (Human)
Length = 619
Score = 98.3 bits (234), Expect = 5e-19
Identities = 59/182 (32%), Positives = 101/182 (55%), Gaps = 10/182 (5%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEE----LVRLLNELFARFDR 359
+A++ RH++ + +RY+NV+ILF+ I GF + + + E +V LLN+L+ RFD
Sbjct: 402 VANELRHKR--PVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459
Query: 360 LAAEHH---CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVN 416
L +++ +GD Y VSGLPE HA+ + LDM++ V +V +V
Sbjct: 460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQ 518
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+ +GIHTG V V+G R ++ ++ N V L + E+ G G++++++ T CL
Sbjct: 519 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578
Query: 477 EP 478
+P
Sbjct: 579 DP 580
>UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalytic
domain containing protein; n=1; Babesia bovis|Rep:
Adenylate and guanylate cyclase catalytic domain
containing protein - Babesia bovis
Length = 2446
Score = 97.9 bits (233), Expect = 6e-19
Identities = 59/200 (29%), Positives = 105/200 (52%), Gaps = 9/200 (4%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
+H++ Y +E +S LF+DI GFT ++ A +++ LL LFARFDR + +H +
Sbjct: 2242 KHDKLKMSYC--HEKMSFLFSDIVGFTLWANSVDAGQVITLLQRLFARFDRSSTKHGLYK 2299
Query: 369 IKLLGDCYYCVS----GLPEARDDHAKC--CVEMGLDMIDAIALVREVMAV-NVNMRVGI 421
+ +GD Y VS +P ++ A ++M MI I VRE + +NMR+G+
Sbjct: 2300 LCTIGDAYVAVSEPAIEVPTEQEAIANIDGILQMAQSMIRTIRDVRESFDIPGLNMRIGL 2359
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHG 481
H G V+G + ++D+W D+ AN MES G+ G+++I++ L ++
Sbjct: 2360 HYGHAVGGVIGSGRLRYDLWGMDIHTANAMESHGIPGKINISERLKLILMTNFPERFTFE 2419
Query: 482 GYRNAYLKDHNIETYLIVPD 501
+ + + D + +++I D
Sbjct: 2420 FHSDVQVIDRCVRSFIITSD 2439
Score = 65.3 bits (152), Expect = 4e-09
Identities = 50/198 (25%), Positives = 94/198 (47%), Gaps = 20/198 (10%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
VS++F D+C F +L LV LL+ LF FDR A + +I+ + + Y GL
Sbjct: 1596 VSVVFCDVCNFQNLVATVEPTILVELLDSLFLAFDRCAEQFGATKIETVFETYLAALGLS 1655
Query: 384 EAR----DDHAKCCVEMGLDMIDAIALVREVMAVNVN------------MRVGIHTGRVH 427
+ A ++M L MI+ +R + ++VGI++G++
Sbjct: 1656 RGNIICPYEAAANSIDMALAMIEVARSIRYTSMQERDDGTFAEQDDVAVVKVGINSGKII 1715
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAY 487
++G +K Q+ ++ + V A+ M++ G +G +HI+ T + D + H +R +
Sbjct: 1716 SGLVGFKKPQYALFGDTVNTASRMKTTGESGYIHISTSTYDLVKSDVTL---HFEHRETF 1772
Query: 488 LKDHNI-ETYLIVPDDTS 504
+K I T+L++ + S
Sbjct: 1773 VKGKGIMNTHLLISAEGS 1790
>UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n=48;
Euteleostomi|Rep: Retinal guanylyl cyclase 2 precursor -
Homo sapiens (Human)
Length = 1108
Score = 97.9 bits (233), Expect = 6e-19
Identities = 53/163 (32%), Positives = 93/163 (57%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 880 FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 939
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ ++ +R + V V +R+G+H+G V V+GL +
Sbjct: 940 GLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPR 999
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCC---LGDDYKVE 477
+ ++ + V A+ MES G+ R+H++ T+ L + Y+VE
Sbjct: 1000 YCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
>UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000009149 - Nasonia
vitripennis
Length = 1329
Score = 97.5 bits (232), Expect = 8e-19
Identities = 59/179 (32%), Positives = 98/179 (54%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LPR+VA ++K HK+ + ++ V+I F+DI GFT++S + T ++V L
Sbjct: 876 MLPRYVAEQLKRG----------HKVEAENFDCVTIYFSDIVGFTAMSAESTPLQVVDFL 925
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD-DHAKCCVEMGLDMIDAIA--LV 407
N+L+ FD + +++ +GD Y VSGLP HA M L ++DAI +
Sbjct: 926 NDLYTCFDSTIENYDVYKVETIGDAYMVVSGLPIRNGIQHAGEIASMSLHLLDAIKQFSI 985
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
R + +R+GIH+G V V+GL+ ++ ++ + V A+ MES G R+H + ET
Sbjct: 986 RHRPLDKLQLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGSPLRIHCSTET 1044
>UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA;
n=2; Endopterygota|Rep: PREDICTED: similar to CG9783-PA
- Tribolium castaneum
Length = 1044
Score = 97.5 bits (232), Expect = 8e-19
Identities = 50/150 (33%), Positives = 85/150 (56%), Gaps = 2/150 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E V+I F+DI GFT++S T ++V LLN+L+ FD ++ +++ +GD Y
Sbjct: 847 EEFEEVTIYFSDIVGFTTISAHSTPFQVVDLLNDLYTCFDATINAYNVYKVETIGDAYMV 906
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVR--EVMAVNVNMRVGIHTGRVHCVVLGLRKW 436
V GLP DHA+ M LD++ R + + +R+G+HTG V+GL
Sbjct: 907 VGGLPVRVPDHAEQIATMALDLLHQSGRFRITHLPGTPLRLRIGLHTGPCCAGVVGLTMP 966
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G A R+H+++ T
Sbjct: 967 RYCLFGDTVNTASRMESTGAAWRIHLSEAT 996
>UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1;
Flavobacteriales bacterium HTCC2170|Rep:
Adenylate/guanylate cyclase - Flavobacteriales bacterium
HTCC2170
Length = 394
Score = 97.5 bits (232), Expect = 8e-19
Identities = 48/157 (30%), Positives = 87/157 (55%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+R++++++LF D FT L +A LV LN++F RFD + AE +I+ +GD Y
Sbjct: 217 KRHKDITVLFTDFENFTKLVASISAITLVNELNDIFGRFDEIMAETEVEKIETIGDSYMA 276
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
GL + +HA C+ M+ + + + MRVGIH+G V V+G +K+ +
Sbjct: 277 ACGLEKEMANHAANCIRAAQMMLSYLEERNKSHEIKWKMRVGIHSGTVVAGVVGKKKFAY 336
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
D++ + + A+ +E G G+++I+ T + +D+K
Sbjct: 337 DLFGDTINTASRIEFAGEVGKINISSSTYEQIKNDFK 373
>UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP04501p
- Drosophila melanogaster (Fruit fly)
Length = 710
Score = 97.1 bits (231), Expect = 1e-18
Identities = 59/178 (33%), Positives = 98/178 (55%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP VAM++K Q ++ + YE V+I F+DI GFT ++ CT E+V L
Sbjct: 470 MLPPSVAMQLK----------QTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFL 519
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP-EARDDHAKCCVEMGLDMIDAIALVRE 409
N ++ FD + +++ +GD Y SGLP + + H M LD++DA ++ R
Sbjct: 520 NSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRI 579
Query: 410 VMAVN--VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
A + V +R G+HTG V ++G + ++ ++ + V A+ MES G A ++HIT+E
Sbjct: 580 PRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEE 637
>UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane
guanylyl cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to membrane guanylyl cyclase -
Strongylocentrotus purpuratus
Length = 1376
Score = 96.3 bits (229), Expect = 2e-18
Identities = 58/167 (34%), Positives = 91/167 (54%), Gaps = 6/167 (3%)
Query: 297 AMEMKADIASQPRHEQFHK---IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNEL 353
A E+ I +P E+ K + + +E V+I F+DI GFT LS T E+V LLN+L
Sbjct: 1102 AEELLYQILPRPVAEELKKGKPVTAESFECVTIYFSDIVGFTKLSSASTPLEVVDLLNDL 1161
Query: 354 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREV 410
+ FD + + +++ +GD Y CVSGLP D HA+ M L ++ I +R
Sbjct: 1162 YTCFDAVIDNFNVYKVETIGDAYMCVSGLPIRNGDFHAREIARMSLALLHEITSFRIRHR 1221
Query: 411 MAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ +R+G+HTG V V+GL+ ++ ++ + V A+ MES G A
Sbjct: 1222 PEERLRLRIGVHTGPVVAGVVGLKMPRYCLFGDTVNTASRMESNGEA 1268
>UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: Putative
adenylate/guanylate cyclase - Victivallis vadensis ATCC
BAA-548
Length = 281
Score = 96.3 bits (229), Expect = 2e-18
Identities = 52/175 (29%), Positives = 92/175 (52%), Gaps = 10/175 (5%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP V ++ + AS+P + ++NV++ F+DI GFT +S + T E ++
Sbjct: 84 NILPERVIRVLQREGASKP----------ELFDNVTVFFSDIVGFTRMSAELTPEAVIAE 133
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
L+++F +FD + H C RIK +GD Y V GLPE R +H + L+ + +
Sbjct: 134 LSDIFTQFDHIFTSHGCERIKTIGDAYLAVCGLPEPRPEHCANILRSALEARAYLERRNQ 193
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITK 464
MR GIH+G V ++G K+ +D++ + V A ME R+++++
Sbjct: 194 DSPHQWRMRFGIHSGSVVGGIVGTEKYLYDIFGDTVNTAARMEQLSEPMRINVSE 248
>UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmodium
(Vinckeia)|Rep: Guanylyl cyclase, putative - Plasmodium
berghei
Length = 1993
Score = 96.3 bits (229), Expect = 2e-18
Identities = 56/154 (36%), Positives = 92/154 (59%), Gaps = 9/154 (5%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ ++ LFADICGFTS ++ A E++ LL +LFARFD + ++ ++ +GD Y +S
Sbjct: 1733 HDRLTFLFADICGFTSWANGVDASEVLTLLQKLFARFDNDSTKYGLYKLCTIGDAYVAIS 1792
Query: 381 -GLPEARDDH-----AKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTGRVHCVVLGL 433
+ E +D+ + +EM MI I VRE + + N+NMR+G+H G V+G
Sbjct: 1793 EPVTEDNNDYDPVDGTERILEMAYSMIRIIKEVREKLCIPNLNMRIGLHYGSCVGGVIGS 1852
Query: 434 RKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ ++D+W DV N M S GV G+++++ ETL
Sbjct: 1853 GRLRYDLWGIDVLTGNLM-SNGVPGKINVS-ETL 1884
Score = 40.7 bits (91), Expect = 0.10
Identities = 21/70 (30%), Positives = 34/70 (48%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
E V+I+F DI F ++ LV +L+ LF FD+ +C +I+ + + Y G
Sbjct: 888 ETVTIIFCDIYEFQNIVATIEPTRLVEMLDRLFLCFDKCTEHFNCTKIETVFETYLAACG 947
Query: 382 LPEARDDHAK 391
L + D K
Sbjct: 948 LVKKCSDDNK 957
Score = 39.5 bits (88), Expect = 0.23
Identities = 17/59 (28%), Positives = 37/59 (62%)
Query: 415 VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
+ +++GI++GR+ V+G +K Q+ ++ + V A+ M++ G +HI++ T + DD
Sbjct: 1022 IRVKIGINSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYDLIKDD 1080
>UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1128
Score = 95.9 bits (228), Expect = 3e-18
Identities = 50/154 (32%), Positives = 90/154 (58%), Gaps = 3/154 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT++S + T E+V LLN+L+ FD + + +++ +GD
Sbjct: 942 VQAEAFDSVTIYFSDIVGFTAISAESTPLEVVTLLNDLYTCFDAIIDNFNVYKVETIGDA 1001
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSGLP HA M L ++DA+ +R + +R+GIH+G V V+G
Sbjct: 1002 YMVVSGLPVRNGALHAPEIARMALALLDAVRTFQIRHRPEEQLKLRIGIHSGPVCAGVVG 1061
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
L+ ++ ++ + V ++ MES G A ++H++ T
Sbjct: 1062 LKMPRYCLFGDTVNTSSRMESSGEALKIHVSAAT 1095
>UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep:
Guanylate cyclase - Manduca sexta (Tobacco hawkmoth)
(Tobacco hornworm)
Length = 1258
Score = 95.9 bits (228), Expect = 3e-18
Identities = 49/150 (32%), Positives = 85/150 (56%), Gaps = 2/150 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E VSI F+DI GFT+L+ + T ++V LLN+L+ FD ++ +++ +GD Y
Sbjct: 910 EEFEEVSIYFSDIVGFTALAARSTPVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRKW 436
V GLP+ DHA+ M L ++ VR + +++R+G+H+G V+GL
Sbjct: 970 VGGLPKRARDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHSGPCCAGVVGLTMP 1029
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G A R+ + T
Sbjct: 1030 RYCLFGDTVNTASRMESTGAAWRIQTSAAT 1059
>UniRef50_UPI00006D0DB9 Cluster: Sodium/calcium exchanger protein;
n=1; Tetrahymena thermophila SB210|Rep: Sodium/calcium
exchanger protein - Tetrahymena thermophila SB210
Length = 5392
Score = 95.5 bits (227), Expect = 3e-18
Identities = 55/180 (30%), Positives = 98/180 (54%), Gaps = 9/180 (5%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP H+ + SQ + +Q +N ++LFADI GFT E+++++
Sbjct: 4050 NLLPSHIM----GQLLSQQQDQQSE--LTDSLQNTTLLFADIAGFTKYCSGKEPEKVLQM 4103
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD---HAKCCVEMGLDMIDAIAL 406
L +LF +FD+ ++ ++ +GDCY + L + AK +EM MI +I
Sbjct: 4104 LQKLFVQFDKACIDNEVYKVYTIGDCYVVMGTLNAKQRKPPIEAKHVIEMAFSMIKSIDE 4163
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+++ +++MR+GIHTG + V+G ++D++ +V +AN MES G GRV I++ T
Sbjct: 4164 MKKREFSDIDMRIGIHTGDIIGGVIGTDIVRYDIYGPNVLIANKMESNGERGRVMISETT 4223
Score = 47.6 bits (108), Expect = 9e-04
Identities = 36/160 (22%), Positives = 75/160 (46%), Gaps = 13/160 (8%)
Query: 318 IQRYEN-VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCY 376
+ + EN V+I+F DI F + + E +++LL+ L+ FD L + +I+ +G Y
Sbjct: 2432 VVKIENQVAIIFCDIYNFDDIIAKKNVE-VIKLLDNLYRAFDILCNLNGLQKIETVGKTY 2490
Query: 377 YCVSGLPEAR----------DDHAKCCVEMGLDMID-AIALVREVMAVNVNMRVGIHTGR 425
G+ +++ + KC + ++++ + L + +++GIH G
Sbjct: 2491 MACGGIVQSKLQQREGQYSEVNEVKCAINFAFEILEYSSTLTFGEDGEKIQLKIGIHFGN 2550
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V V+G K QF + + V + + S G V ++++
Sbjct: 2551 VIAGVIGYHKPQFSLIGDTVNTTSRVCSTSEPGTVTLSEQ 2590
>UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 584
Score = 95.5 bits (227), Expect = 3e-18
Identities = 49/154 (31%), Positives = 90/154 (58%), Gaps = 2/154 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC-YY 377
+ ++ ++LF+ + GFTS+ + A + V L+N LF +FD L +H+ + + LGD Y
Sbjct: 415 EEFDAATVLFSYMDGFTSICTRLNAMQAVTLINNLFIKFDLLTEKHNVYKFETLGDALYM 474
Query: 378 CVSGLPEARDDHAKCCVEMGLDMIDAIALVRE-VMAVNVNMRVGIHTGRVHCVVLGLRKW 436
VSG+P + HA+ M LDM+ A+ LV++ + + + VGIH+G V ++G R
Sbjct: 475 AVSGVPVRTEHHAEPMAAMALDMLKAVQLVKDPITKKPMTITVGIHSGPVAAGLVGERTL 534
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
Q+ ++ + V +A+ + + + R+HI++ CL
Sbjct: 535 QYCLFGDTVNIASRLRTTALPMRIHISENCRECL 568
>UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=3; Danio rerio|Rep: PREDICTED:
similar to receptor type guanylyl cyclase - Danio rerio
Length = 479
Score = 95.1 bits (226), Expect = 4e-18
Identities = 49/151 (32%), Positives = 87/151 (57%), Gaps = 3/151 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ Y+ V+I F+DI GFT++S T ++V +LN+L+ FD + H+ +++ +GD Y
Sbjct: 293 ETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMV 352
Query: 379 VSGLP-EARDDHAKCCVEMGLDMIDAIALVR--EVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP DDHAK M L ++ + V + +R+G+H+G V+GL+
Sbjct: 353 VSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKM 412
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G+ ++H++ T
Sbjct: 413 PRYCLFGDTVNTASRMESYGLPLKIHVSSST 443
>UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to receptor type
guanylyl cyclase - Strongylocentrotus purpuratus
Length = 688
Score = 95.1 bits (226), Expect = 4e-18
Identities = 49/141 (34%), Positives = 85/141 (60%), Gaps = 2/141 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
++YE+V+I F+DI GFTSL+ C+ ++V +LN L++ FD +++ +++ +GD Y
Sbjct: 430 EQYEHVTIYFSDIVGFTSLAAACSPLQVVNMLNGLYSMFDGCIDKYNVYKVETIGDAYMV 489
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRKW 436
VSGLP+A D HA M L++ + V + + +R+GIH+G V+GL+
Sbjct: 490 VSGLPDATDRHAWEISTMALELRSLVMGFKVPHMNDATLRLRIGIHSGSCVAGVVGLKMP 549
Query: 437 QFDVWSNDVTLANYMESGGVA 457
++ ++ + V A+ MES G A
Sbjct: 550 RYCLFGDTVNTASRMESSGEA 570
>UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 408
Score = 95.1 bits (226), Expect = 4e-18
Identities = 58/192 (30%), Positives = 103/192 (53%), Gaps = 14/192 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP +A E+KA S+ R+ Y VS+LFADI GFT+ +++ +A ++V+
Sbjct: 176 NILPEDIAEELKASGRSEARN----------YNTVSVLFADIKGFTTAAEKMSAADVVKH 225
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
L F FD + ++ +IK +GD Y G+P+ ++ V L+M + + +E
Sbjct: 226 LEYYFTAFDEIMEKYELEKIKTIGDAYMAAGGIPQPNTSNSLEMVCAALEMQNFMRQHKE 285
Query: 410 VMAVNVN----MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ + +R+GI+TG + V+G K+ +DVW + V A+ MES G +V+I+
Sbjct: 286 ARRSSNDLCWELRLGINTGPLVAGVIGKNKFAYDVWGDTVNTASRMESNGEVNKVNISGV 345
Query: 466 TLCCLGDDYKVE 477
T + D ++ E
Sbjct: 346 THQLVKDYFECE 357
>UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A;
n=1; Microscilla marina ATCC 23134|Rep: Atrial
natriuretic peptide receptor A - Microscilla marina ATCC
23134
Length = 562
Score = 94.7 bits (225), Expect = 6e-18
Identities = 57/192 (29%), Positives = 99/192 (51%), Gaps = 14/192 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
++LP VA E+K + SQ R+ Y+ +++F D GFT ++ E+V+
Sbjct: 331 NILPSDVAEELKINGKSQVRN----------YDMATVMFTDFKGFTKIASFTDPAEIVKN 380
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
L+ FA FD++ E++ +IK +GD Y CV G+P +A L + +A R
Sbjct: 381 LDTCFAAFDQIIEEYNLEKIKTIGDAYMCVGGIPNENKSNAVDATLAALSIRKFMADFRT 440
Query: 410 VMAVN----VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ +R+GI+TG + V+G +K+ +DVW + V A+ MES GV + +++
Sbjct: 441 EKLLRGEQVWELRLGINTGPLIAGVIGTKKFAYDVWGDTVNTASRMESNGVVNEISVSQV 500
Query: 466 TLCCLGDDYKVE 477
T + D ++ E
Sbjct: 501 TYELVKDFFECE 512
>UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theileria
parva|Rep: Cation-transporting ATPase - Theileria parva
Length = 2664
Score = 94.7 bits (225), Expect = 6e-18
Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 10/218 (4%)
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
E+ YI +EN+S LF+DI GFT ++ E++ LL +LFA FDR + ++
Sbjct: 2449 ERLKMCYI--HENMSFLFSDIVGFTKWAESVDPSEVIALLQKLFANFDRNTTNFNLYKLC 2506
Query: 371 LLGDCYYCVS-----GLPEARDDHAKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHTG 424
+GD Y +S + R + + M MI I ++ ++ ++ MR+G+H G
Sbjct: 2507 TIGDAYVAISEPKVIDNKDMRIQDLENILLMAYSMIHIIDETSKIFSIPDLKMRIGLHYG 2566
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYR 484
V+G + ++DVW DV AN +ES GV G V ++++ + + ++
Sbjct: 2567 SCIGGVIGSGRLRYDVWGTDVYTANMIESNGVPGEVCVSEKFRDIITRHFPNRFKFEHHK 2626
Query: 485 NAYLKDHNIETYLIVPDDTSRVDKKP--QHSFAVNGNV 520
+ + D +++Y+I + K P Q +FA GNV
Sbjct: 2627 DINIIDKTVKSYIIRNKSKEAMQKSPFSQMNFADAGNV 2664
Score = 50.0 bits (114), Expect = 2e-04
Identities = 23/73 (31%), Positives = 39/73 (53%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+R+ENV+++FAD+ F L LV +L+ LF FDR + E + ++I+ + + Y
Sbjct: 1695 ERHENVTVIFADVYNFQELIATIEPHRLVEILDTLFLSFDRCSKEFNAIKIETVSETYLT 1754
Query: 379 VSGLPEARDDHAK 391
GL + K
Sbjct: 1755 SMGLNTSSTSQTK 1767
Score = 42.7 bits (96), Expect = 0.025
Identities = 21/88 (23%), Positives = 48/88 (54%)
Query: 390 AKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLAN 449
A ++M + M+ ++ ++ +++GI++G V ++G +K Q+ ++ + V A+
Sbjct: 1815 ASSSLDMSIAMLQVATTIKLNTNESIGVKIGINSGYVISGLVGSKKPQYALFGDTVNTAS 1874
Query: 450 YMESGGVAGRVHITKETLCCLGDDYKVE 477
M+ G GR+HI++ T + D +E
Sbjct: 1875 RMKMTGEVGRIHISESTYELVKGDKTLE 1902
>UniRef50_Q18628 Cluster: Putative uncharacterized protein acy-3;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein acy-3 - Caenorhabditis elegans
Length = 1109
Score = 94.7 bits (225), Expect = 6e-18
Identities = 65/244 (26%), Positives = 105/244 (43%), Gaps = 7/244 (2%)
Query: 234 QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLP 293
+L I I N G+ + R AFL R+ EA S LP
Sbjct: 10 KLLAIIVVHIWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNKLLSSFLP 69
Query: 294 RHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNEL 353
H+ + + I H +Y + Y VS+ + + GF S+ QC++ + R+L EL
Sbjct: 70 YHLINQARHQITLYKPH-----LYNETYSQVSVAYGRLVGFESVLAQCSSIDAARVLKEL 124
Query: 354 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAV 413
+R +RLAA + C R+ G C +P HA +++ I R+
Sbjct: 125 DSRIERLAASNGCTRVASEGITAVC--SIPGIDSQHATKLCRFSMELETLINSFRDATGA 182
Query: 414 NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
+V++ +GI +G V V+G+ KW +DV + A M+S V+++ ET LG
Sbjct: 183 DVSVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGST 242
Query: 474 YKVE 477
+ E
Sbjct: 243 GEFE 246
>UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1;
Manduca sexta|Rep: NO-insensitive guanylyl cyclase -
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Length = 500
Score = 94.3 bits (224), Expect = 8e-18
Identities = 58/179 (32%), Positives = 99/179 (55%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA ++ I QP + + Y+ V+I F+DI GFT LS + T E+V LL
Sbjct: 141 LLPKSVASQL---IMGQP-------VMAETYDQVTIYFSDIIGFTQLSAESTPLEVVDLL 190
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--V 407
N+L+ FD + +++ +GD Y VSGLP + HA M L +++A+ + V
Sbjct: 191 NDLYTSFDSIIENFDVYKVETIGDAYMVVSGLPMRNGNRHAAEIARMSLALLNAVRVKTV 250
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +R+G+HTG V+GL+ ++ ++ + V A+ MES G A ++H++ +T
Sbjct: 251 PHRPGERLLLRIGMHTGPCVAGVVGLKMPRYCLFGDTVNTASRMESHGEALKIHVSPKT 309
>UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1
precursor; n=5; Caenorhabditis|Rep: Guanylate cyclase
receptor-type gcy-1 precursor - Caenorhabditis elegans
Length = 1137
Score = 94.3 bits (224), Expect = 8e-18
Identities = 54/187 (28%), Positives = 99/187 (52%), Gaps = 13/187 (6%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA +KA +P + +++V++ F+D+ FT L+ +C+ + V LL
Sbjct: 874 MLPKQVAERLKAGQTVEP----------EGFDSVTVFFSDVVKFTILASKCSPFQTVNLL 923
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD-DHAKCCVEMGLDMIDAIAL--V 407
N+L++ FD + +H +++ +GD Y CVSGLP H K V+M L ++ +
Sbjct: 924 NDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCKSFNI 983
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETL 467
+ NV +R+G+++G V+GL ++ ++ + V A+ MES G +H+T +
Sbjct: 984 PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAH 1043
Query: 468 CCLGDDY 474
L Y
Sbjct: 1044 SLLTTHY 1050
>UniRef50_P16065 Cluster: Speract receptor precursor; n=7;
Euechinoidea|Rep: Speract receptor precursor -
Strongylocentrotus purpuratus (Purple sea urchin)
Length = 1125
Score = 93.9 bits (223), Expect = 1e-17
Identities = 56/165 (33%), Positives = 95/165 (57%), Gaps = 7/165 (4%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E VSI F+DI GFT+LS T ++V LLN+L+ FD + + + +++ +GD Y
Sbjct: 908 ETFEMVSIFFSDIVGFTALSAASTPIQVVNLLNDLYTLFDAIISNYDVYKVETIGDAYML 967
Query: 379 VSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP D HA +++++ +V V + +R+GIH+G V+GL
Sbjct: 968 VSGLPLRNGDRHAGQIASTAHHLLESVKGFIVPHKPEVFLKLRIGIHSGSCVAGVVGLTM 1027
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHIT---KETLCCLGDDYKVE 477
++ ++ + V A+ MES G+A R+H++ K+ L LG Y++E
Sbjct: 1028 PRYCLFGDTVNTASRMESNGLALRIHVSPWCKQVLDKLG-GYELE 1071
>UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 93.5 bits (222), Expect = 1e-17
Identities = 52/178 (29%), Positives = 97/178 (54%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA +KA +P + +++V++ F+D+ FT L+ +C+ + V LL
Sbjct: 848 MLPKQVAERLKAGQTVEP----------EGFDSVTVFFSDVVKFTILASKCSPFQTVNLL 897
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD-DHAKCCVEMGLDMIDAIA--LV 407
N+L++ FD + +H +++ +GD Y CVSGLP H K V+M L ++ +
Sbjct: 898 NDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCRSFKI 957
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ NV +R+G+++G V+GL ++ ++ + V A+ MES G +H+T +
Sbjct: 958 PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSD 1015
>UniRef50_O16544 Cluster: Guanylate cyclase; n=3;
Caenorhabditis|Rep: Guanylate cyclase - Caenorhabditis
elegans
Length = 1143
Score = 93.5 bits (222), Expect = 1e-17
Identities = 47/150 (31%), Positives = 87/150 (58%), Gaps = 3/150 (2%)
Query: 309 RHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLR 368
R +Q + + +++V++ F+D+ FT L+ +C+ ++V LLN+L++ FD + EH C +
Sbjct: 844 RLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYK 903
Query: 369 IKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGR 425
++ +GD Y CVSGLP + H K VE+ LD + + + V +R+G+++G
Sbjct: 904 VESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGP 963
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGG 455
V+GL ++ ++ + V A+ MES G
Sbjct: 964 CVAGVVGLSMPRYCLFGDTVNTASRMESNG 993
>UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to guanylate cyclase - Nasonia vitripennis
Length = 1542
Score = 93.1 bits (221), Expect = 2e-17
Identities = 49/150 (32%), Positives = 89/150 (59%), Gaps = 3/150 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ ++ V+I F+DI GFT++S + T ++V LN+L+ FDR+ + +++ +GD Y
Sbjct: 965 EAFDLVTIYFSDIVGFTAMSAESTPFQVVNFLNDLYTLFDRIIKGYDVYKVETIGDAYMV 1024
Query: 379 VSGLP-EARDDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP + + HA M L++++A+ + + + +R+GIHTG V V+GL
Sbjct: 1025 VSGLPIKNGNRHAGEIASMSLELLNAVKHHTIAHRPSETLKLRIGIHTGPVVAGVVGLTM 1084
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
++ ++ + V A+ MES G R+HI+ +
Sbjct: 1085 PRYCLFGDTVNTASRMESNGEPLRIHISAQ 1114
>UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic
peptide receptor A - Strongylocentrotus purpuratus
Length = 1008
Score = 93.1 bits (221), Expect = 2e-17
Identities = 60/179 (33%), Positives = 97/179 (54%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
VLPR VA ++K A P Y++ +I F+DI GFT+LS T ++V LL
Sbjct: 804 VLPRSVADQLKRGEAVNPTS----------YDSTTIYFSDIVGFTTLSADSTPMQVVTLL 853
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIALVR- 408
N+L+ FD + + +IK + D Y VSGLP + HA+ M L +I ++ R
Sbjct: 854 NDLYTCFDEIIGNYDVYKIKTVCDAYMVVSGLPIGNGNLHAREISAMSLALIKEVSTFRI 913
Query: 409 -EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +RVGIH+G V+GL+ ++ ++ + V A+ MES G A ++H++++T
Sbjct: 914 SHRPEEKLKLRVGIHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESTGEAMKIHLSEKT 972
>UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 420
Score = 93.1 bits (221), Expect = 2e-17
Identities = 51/161 (31%), Positives = 91/161 (56%), Gaps = 4/161 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++NV++LFAD+ FT +S+ ++LV LL+ F R D + +H +IK +GD Y +
Sbjct: 237 HDNVTVLFADVKNFTIVSEGLLPDQLVALLDTYFQRIDAIIQKHGLEKIKTIGDAYLAAA 296
Query: 381 GLPEARDDHAKCCVEMGLDM---IDAIALVREVMAVN-VNMRVGIHTGRVHCVVLGLRKW 436
G+P+ A+ V L++ DA ++RE + + R+GI+TG V V+G +K+
Sbjct: 297 GVPKGNKATARDVVAAALEIQKTNDAYKVLRETEGLPFFDFRIGINTGTVVAGVVGDKKY 356
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
+D+W + V A +E GRV+I+ T + + +++E
Sbjct: 357 VYDIWGDAVNTAARIEENSAPGRVNISAFTHQVVKEHFELE 397
>UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 464
Score = 93.1 bits (221), Expect = 2e-17
Identities = 54/179 (30%), Positives = 94/179 (52%), Gaps = 7/179 (3%)
Query: 303 DIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
+ A + + F K +Q EN +++F D FT S ++EELV L+ F FD +
Sbjct: 265 ETAEELKKYGFAKAKLQ--ENATVMFTDFVNFTKFSSSISSEELVSELDHCFRNFDAITT 322
Query: 363 EHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVN----MR 418
++ +IK +GD + G+ D A + G++M D + + ++ +R
Sbjct: 323 KYRLEKIKTIGDAHMSACGVTGDGGDVADV-IRAGIEMRDFVQSYAKEKPKHLQEYFQIR 381
Query: 419 VGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVE 477
VGI+TG V V+GL+K+ FD+W + V A+ ++SG VAG+V++++ T D + E
Sbjct: 382 VGINTGPVVAGVVGLKKFSFDIWGDTVNTADRIQSGSVAGKVNVSESTYLLTKDLFDFE 440
>UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl
cyclase; n=1; Dechloromonas aromatica RCB|Rep: Adenylyl
cyclase class-3/4/guanylyl cyclase - Dechloromonas
aromatica (strain RCB)
Length = 431
Score = 92.7 bits (220), Expect = 2e-17
Identities = 46/163 (28%), Positives = 91/163 (55%), Gaps = 2/163 (1%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
IA + +H+ + + +V+++F DI FT +++ T +++ +LN +F+ FD LA +
Sbjct: 227 IAERLKHDS--QAIADGFADVTVMFVDIVNFTRIAEGMTPQQVFAMLNRIFSSFDELAEQ 284
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
+ +IK +GD Y GL +++ + E+ + M D + V +++++R+GI T
Sbjct: 285 YGMEKIKTIGDAYMVAGGLNNELNNYTQSIAELAIAMRDLLHRDFTVNDMHLDVRIGIGT 344
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G V V+G +K+ +D+W + V LA+ + S G G + + T
Sbjct: 345 GPVVAGVVGKKKFIYDLWGDTVNLASRITSEGTPGMIQLDATT 387
>UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1417
Score = 92.7 bits (220), Expect = 2e-17
Identities = 53/179 (29%), Positives = 101/179 (56%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA ++ I+ QP + + ++ V+I F+DI GFT++S + T ++V+ L
Sbjct: 929 LLPQSVAAQL---ISGQP-------VVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFL 978
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP-EARDDHAKCCVEMGLDMIDAI--ALV 407
N+L+ FD + +++ +GD Y VSGLP + HA+ + L +++A+ +
Sbjct: 979 NDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRI 1038
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +R+G+HTG V+GL+ ++ ++ + V A+ MES G A ++HI++ T
Sbjct: 1039 HHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETT 1097
>UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 518
Score = 92.7 bits (220), Expect = 2e-17
Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 3/155 (1%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
++ + ++ VSI F+DI GFTSLS + T ++V LLN+L+ FD + + +++ +GD
Sbjct: 329 QVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGD 388
Query: 375 CYYCVSGLP-EARDDHAKCCVEMGLDMIDAI--ALVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP HA M L M+ I +R + +R+GIH+G V+
Sbjct: 389 AYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVV 448
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G + ++ ++ + V A+ MES G A ++HI+ T
Sbjct: 449 GKKMPRYCLFGDTVNTASRMESNGEALKIHISPST 483
>UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 629
Score = 92.3 bits (219), Expect = 3e-17
Identities = 49/153 (32%), Positives = 90/153 (58%), Gaps = 3/153 (1%)
Query: 320 RYENVSILFADICGFTSLSDQCTAE-ELVRLLNELFARFDRLAAEHHCL-RIKLLGDCYY 377
+YE V+I+F+ I FT+ ++ E+V +LNE++ FD+L + + +++ +GD Y
Sbjct: 427 KYEIVTIMFSGIVDFTNYCNKIKEPMEIVEMLNEVYTEFDQLTDSNDDIYKVETVGDKYM 486
Query: 378 CVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
VSGLP D HA + LDMID I+ + + + + +GIH+G V V+G +K +
Sbjct: 487 AVSGLPTRCDKHALNIANLALDMID-ISKGMKAKGIQLQVTIGIHSGEVVAGVVGQKKPR 545
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
+ ++ N V L + E+ G+ G++++++ CL
Sbjct: 546 YCLFGNTVNLTSRTETTGLKGKINVSEYAYRCL 578
>UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor
precursor; n=41; Euteleostomi|Rep: Heat-stable
enterotoxin receptor precursor - Homo sapiens (Human)
Length = 1073
Score = 92.3 bits (219), Expect = 3e-17
Identities = 45/153 (29%), Positives = 88/153 (57%), Gaps = 3/153 (1%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
YE V+I F+DI GFT++ T E+V +LN+++ FD + H +++ +GD Y S
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ + HA +M L+++ + + + + + +R+G+H+G V+G++ +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
+ ++ + V A+ MES G+ R+H++ T+ L
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
>UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific;
n=3; Dictyostelium discoideum|Rep: Adenylate cyclase,
germination specific - Dictyostelium discoideum (Slime
mold)
Length = 858
Score = 92.3 bits (219), Expect = 3e-17
Identities = 52/157 (33%), Positives = 85/157 (54%), Gaps = 5/157 (3%)
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
E + +R N + F DI GFT S + E+++++L ++F D L A+H +IK
Sbjct: 382 ENGEDVVAERSNNACVFFLDIAGFTRFSSIHSPEQVIQVLIKIFNSMDLLCAKHGIEKIK 441
Query: 371 LLGDCYYCVSGL-PEARDDHAKCCVEMGLDMIDAIALVREVMA--VNVNMRVGIHTGRV- 426
+GD Y G+ P+ D +G M D + + + M+ + + +RVGIH G V
Sbjct: 442 TIGDAYMATCGIFPKCDDIRHNTYKMLGFAM-DVLEFIPKEMSFHLGLQVRVGIHCGPVI 500
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHIT 463
V+ G K FDVW + V +A+ MES G+AG++H++
Sbjct: 501 SGVISGYAKPHFDVWGDTVNVASRMESTGIAGQIHVS 537
>UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 574
Score = 91.9 bits (218), Expect = 4e-17
Identities = 49/159 (30%), Positives = 92/159 (57%), Gaps = 3/159 (1%)
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
+Q ++ + +E+V+I F+DI GFT +S TA E+V +LN L+ FD + ++ +++
Sbjct: 352 KQQRQVPAETFESVTIFFSDIVGFTYISAVSTAMEVVTMLNTLYRLFDTIILKYDVYKVE 411
Query: 371 LLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVH 427
+GD Y VSGLP+ D HA M LD++ I+ ++ + + +RVG++TG
Sbjct: 412 TIGDAYMVVSGLPQRNGDKHAGEIAMMSLDLLCGISGFIIPHMKNRTLEIRVGVNTGPCV 471
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
V+G ++ ++ + + A+ MES G ++H+++ T
Sbjct: 472 AGVVGTTMPRYCLFGDTINTASRMESTGEPMKIHLSENT 510
>UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1268
Score = 91.5 bits (217), Expect = 5e-17
Identities = 61/196 (31%), Positives = 102/196 (52%), Gaps = 4/196 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ ++ V+I F+DI GFT LS T ++V LLN+L+ FD + + ++ +++ +GD Y
Sbjct: 873 ESFDCVTIFFSDIVGFTKLSSMSTPFQVVDLLNDLYTLFDDIISYYNVYKVETIGDAYML 932
Query: 379 VSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP D+ HA L +ID + +R + +RVGIH+G V V+GL
Sbjct: 933 VSGLPIRNDNRHAAEIGSTALHLIDEVQKFKIRHRPDDTLKLRVGIHSGPVVTGVVGLTM 992
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIET 495
++ ++ + V ++ MES G A ++H + E L + + G A ++ T
Sbjct: 993 PRYCLFGDTVNTSSRMESNGEALKIHCSAECKAILDEVGGYDVPERGI-VAMKGKGSLLT 1051
Query: 496 YLIVPDDTSRVDKKPQ 511
Y +V D S KP+
Sbjct: 1052 YWLVDQDPSYKRFKPR 1067
>UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1292
Score = 91.5 bits (217), Expect = 5e-17
Identities = 49/154 (31%), Positives = 87/154 (56%), Gaps = 3/154 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + Y+ V+I F+DI GFTS+S Q T ++V LLN+L+ FD + +++ +GD
Sbjct: 1003 VIAETYDQVTIYFSDIVGFTSISAQSTPMQVVDLLNDLYTCFDSIVENFDVYKVETIGDA 1062
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAI--ALVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSGLP + HA+ + L ++ A+ +R + +R+G+H+G V+G
Sbjct: 1063 YMVVSGLPVRNGNLHAREISRLALALLAAVHKFTIRHRPNEQLKLRIGLHSGPCVAGVVG 1122
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
L+ ++ ++ + V A+ MES G ++HI+ T
Sbjct: 1123 LKMPRYCLFGDTVNTASRMESNGEPLKIHISHTT 1156
>UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta-3; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta-3 - Strongylocentrotus purpuratus
Length = 818
Score = 91.1 bits (216), Expect = 7e-17
Identities = 49/145 (33%), Positives = 86/145 (59%), Gaps = 2/145 (1%)
Query: 324 VSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 383
V+ILF+D+ GFT++ + +V LLN ++ +FD L+ + +++ +GD Y VSG P
Sbjct: 425 VTILFSDVVGFTTICSRIPPMAVVSLLNGMYIKFDNLSETYEVYKVETIGDAYMVVSGAP 484
Query: 384 EARDDHAKCCVEMGLDMIDAIALVREVMAVN--VNMRVGIHTGRVHCVVLGLRKWQFDVW 441
HA EM L M +++ + + + + V +RVGIHTG V V+GL+ ++ ++
Sbjct: 485 TTTKYHAVRIAEMSLAMRESMNDLIDPSSKDEIVKIRVGIHTGMVVAGVVGLKMPRYCLF 544
Query: 442 SNDVTLANYMESGGVAGRVHITKET 466
+ V A+ MES G A ++H+++ T
Sbjct: 545 GDTVNTASRMESTGEALKIHMSETT 569
>UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:
Guanylyl cyclase 2 - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 259
Score = 91.1 bits (216), Expect = 7e-17
Identities = 55/169 (32%), Positives = 90/169 (53%), Gaps = 13/169 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP VA +K +P H +E+VS+ F+DI GFT++S E+V LL
Sbjct: 101 MLPPSVAEALKLGTTVEPEH----------FESVSLYFSDIVGFTTISANSEPIEVVDLL 150
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIAL--V 407
N+L+ FD + H +++ +GD Y SG+P + HA M LD++ A+ +
Sbjct: 151 NDLYTTFDAVIGNHDVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVGTFRM 210
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
R + V V +R+G+HTG V+ L ++ ++ + VT A+ MES G+
Sbjct: 211 RHMPDVPVRIRIGLHTGPCVAGVVXLTMPRYCLFGDTVTTASRMESTGL 259
>UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1;
Plesiocystis pacifica SIR-1|Rep: Adenylate or guanylate
cyclase - Plesiocystis pacifica SIR-1
Length = 601
Score = 90.6 bits (215), Expect = 1e-16
Identities = 54/182 (29%), Positives = 88/182 (48%), Gaps = 16/182 (8%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
V+P + E+K P+H +E+ +++FAD+ GFT +S LV L
Sbjct: 374 VMPASIVRELKLHQRVDPKH----------HEDATVVFADLVGFTRISTTLEPRSLVAEL 423
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREV 410
+ LF FD +AA ++K +GD Y V+GLP+ HA L + +A+
Sbjct: 424 DRLFRAFDDVAARWQLEKLKTIGDAYMAVAGLPDPHPRHALAATLAALHLREAVRAYAAS 483
Query: 411 MAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITK 464
A + ++RVG+H+G + ++G K +DVW V A MES A R++++
Sbjct: 484 PAADGQIKPPWSVRVGLHSGPLIAGIIGRAKLAYDVWGETVNTAARMESSSAADRINVSA 543
Query: 465 ET 466
T
Sbjct: 544 PT 545
>UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-34 -
Caenorhabditis elegans
Length = 686
Score = 90.2 bits (214), Expect = 1e-16
Identities = 56/201 (27%), Positives = 105/201 (52%), Gaps = 5/201 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
YE +++F D+ F + C + +V+LLNE+F + DR+ +++ + D Y VS
Sbjct: 452 YE-ATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVS 510
Query: 381 GLPEARDDHAK--CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
G+P+ +HA+ C V +G+ M +A +++ V +R+G+H+G + V+G + ++
Sbjct: 511 GIPDYTSEHAENMCHVALGM-MWEARSVMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRY 569
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLI 498
++ VTLA+ MES GVAG++ + T + + E G N + ++ETY +
Sbjct: 570 CLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRG-DVETYFL 628
Query: 499 VPDDTSRVDKKPQHSFAVNGN 519
+ + + H VN N
Sbjct: 629 MRSLKKSIWEITDHERDVNVN 649
>UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate
cyclase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 699
Score = 89.8 bits (213), Expect = 2e-16
Identities = 54/178 (30%), Positives = 97/178 (54%), Gaps = 7/178 (3%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
+A+Q H + + + Y++ ++ FADI GF+ L + + ++V +LN L+ FD
Sbjct: 447 VANQLMHG--YNVQAEWYDSATVFFADIFGFSRLCAESSPMQVVEMLNGLYLVFDSRIEH 504
Query: 364 HHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIALVREVMAVN--VNMRVG 420
+ +++ + + Y SGLP + D HA + LD+ ++ + N + +RVG
Sbjct: 505 YDVYKVETINETYMLASGLPVRKGDQHAGEVATIALDLQYHVSFLEVPHKRNEKLTIRVG 564
Query: 421 IHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD--DYKV 476
IH+G V V+GL+ ++ ++ + V +A+ M++ GV GRV I+ ET L D YKV
Sbjct: 565 IHSGPVVAAVVGLKMPRYCLFGDTVNIASRMQTTGVPGRVQISYETFAALNDLGGYKV 622
>UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 520
Score = 89.4 bits (212), Expect = 2e-16
Identities = 55/169 (32%), Positives = 93/169 (55%), Gaps = 13/169 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LPR++A +K +P + + Y +V+I F+DI GFT L+ T ++V LL
Sbjct: 361 MLPRYIAESLKR---GEP-------VIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLL 410
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIALVRE 409
N+L+ FD + +H +++ +GD Y VSGLP HA M L+++ ++ R
Sbjct: 411 NDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRA 470
Query: 410 VMAVN--VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
N +++R+GIHTG V+GL+ ++ ++ + V A+ MES GV
Sbjct: 471 RHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519
>UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6;
Murinae|Rep: Guanylate cyclase 2G precursor - Mus
musculus (Mouse)
Length = 1100
Score = 89.0 bits (211), Expect = 3e-16
Identities = 45/151 (29%), Positives = 83/151 (54%), Gaps = 3/151 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E+V+I F+DI GFT L + ++V+LLN+L++ FD H +++ +GD Y
Sbjct: 895 EHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMV 954
Query: 379 VSGLPEARD-DHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
SGLP HA M L ++ + + + +R+G+HTG V V+G+
Sbjct: 955 ASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITM 1014
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V +A+ MES + R+H+++ T
Sbjct: 1015 PRYCLFGDTVNMASRMESSSLPLRIHVSQST 1045
>UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 554
Score = 88.2 bits (209), Expect = 5e-16
Identities = 59/191 (30%), Positives = 92/191 (48%), Gaps = 19/191 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + R +Y Q Y V +LFA + F+ + T E
Sbjct: 332 NVLPMHVAEHFMGN-----RKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLE 386
Query: 346 LVRLLNELFARFD---RLAAEHHCLRIKLLGDCYYCVSGLPEARDD-------HAKCCVE 395
+R LNE+ + FD L ++IK +G Y SGL +R D H VE
Sbjct: 387 CLRFLNEVISDFDALLELPQFQDVIKIKTIGSTYMAASGLNPSRIDPISVRWAHLALLVE 446
Query: 396 MGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGG 455
L++ A+ + E + +++G++ G + V+G RK +D+W N V +A+ MES G
Sbjct: 447 FALELKKALQGINEQSFNHFVLKMGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTG 506
Query: 456 VAGRVHITKET 466
AG + +T+ET
Sbjct: 507 KAGAIQVTEET 517
>UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 650
Score = 87.8 bits (208), Expect = 7e-16
Identities = 42/153 (27%), Positives = 87/153 (56%), Gaps = 3/153 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
++ + + +ILF+DI GFT + + + ++V +LN ++ +FD ++ +++ +GD
Sbjct: 434 VHAENFTAATILFSDIVGFTRICSESSPLQVVDMLNNVYTKFDSRIDTYNVYKVETIGDA 493
Query: 376 YYCVSGLPEAR-DDHAKCCVEMGLDMIDAI--ALVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSG+P+ + HA M LD+++ I ++ + +R+GIHTG V ++G
Sbjct: 494 YMVVSGVPQRNGNKHASEIALMALDLLNCIKGLVIPHRPGTKMTLRIGIHTGPVVAGIVG 553
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
+ ++ ++ V +A+ MES G+ R+ I+ +
Sbjct: 554 SKMPRYCLFGETVNIASKMESNGLPNRIQISDD 586
>UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 769
Score = 87.8 bits (208), Expect = 7e-16
Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 5/169 (2%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLA-- 361
+A++ RH + + +R E V++LF+ I F + E+V LLN ++ +FD L
Sbjct: 509 VANELRHNR--PVQAERAEMVTLLFSGIVDFAQICKNSKPMEIVMLLNNIYTKFDMLTDP 566
Query: 362 AEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGI 421
+ + +++ +GD Y VSGLPE HA+ M LDM + + +++GI
Sbjct: 567 SINDVYKVETVGDKYMAVSGLPERCAFHARSICNMALDMKHVTQSIIH-KGDKIQIKIGI 625
Query: 422 HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
H+G V V+G + ++ ++ N V L + E+ G G+V+IT+ T CL
Sbjct: 626 HSGEVVAGVVGHKTPRYCLFGNTVNLTSRTETTGAPGQVNITEFTYRCL 674
>UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2;
Tetraodontidae|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 1103
Score = 87.4 bits (207), Expect = 9e-16
Identities = 46/139 (33%), Positives = 82/139 (58%), Gaps = 3/139 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V+I F+DI GFT++S E+V LLN+L++ FD + + H +++ +GD Y S
Sbjct: 850 FDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLSSHDVYKVETIGDAYMVAS 909
Query: 381 GLPEAR-DDHAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ + HA M L+++ ++ +R + V V +R+GIH+G V+GL +
Sbjct: 910 GLPKRNGNKHAAEIANMSLNILSSVGTFHMRHMPDVPVRIRIGIHSGACVAGVVGLTMPR 969
Query: 438 FDVWSNDVTLANYMESGGV 456
+ ++ + V A+ MES G+
Sbjct: 970 YCLFGDTVNTASRMESTGL 988
>UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;
Aplysia californica|Rep: Soluble guanylate cyclase
subunit - Aplysia californica (California sea hare)
Length = 801
Score = 87.4 bits (207), Expect = 9e-16
Identities = 45/135 (33%), Positives = 76/135 (56%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSG 381
++V++LF+DI GFT++ T ++V +LN L+ FD+ + +I+ +GD Y G
Sbjct: 658 DDVTMLFSDIVGFTAICSTATPMQVVDMLNSLYTHFDQFCVDIDVYKIETIGDAYCVAGG 717
Query: 382 LPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVW 441
L HA+ M + M+ A + + MR+GIHTGRV V+G + ++ ++
Sbjct: 718 LHRRSAYHAQQIAWMAVKMMAAAENEKSHDGNVIKMRIGIHTGRVLAGVVGRKMPRYCLF 777
Query: 442 SNDVTLANYMESGGV 456
N+V++AN ESG V
Sbjct: 778 GNNVSIANKFESGSV 792
>UniRef50_A2ECV6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1372
Score = 87.4 bits (207), Expect = 9e-16
Identities = 59/175 (33%), Positives = 88/175 (50%), Gaps = 7/175 (4%)
Query: 303 DIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAA 362
+IASQ +Q K E V + F DI FT TAE +V LN +F FD
Sbjct: 1178 EIASQLLKDQ--KSISMTVEKVCVSFCDIVQFTPWCASQTAEGVVNTLNTMFTLFDDKCL 1235
Query: 363 EHHCL-RIKLLGDCYYCVSGLPEARDDHAKCCVEM---GLDMIDAIALVREVMAVNVNMR 418
+ + +IK +GDCY +G+ + D ++ +M LD++D+I V + + +R
Sbjct: 1236 RYRSVTKIKTIGDCYMSAAGIFDKGDSVSESSHQMLSFALDLVDSINEVNAKLGTKLRVR 1295
Query: 419 VGI-HTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
VG+ G + ++G+RK FDV+ V A MESGG +VHI KE + D
Sbjct: 1296 VGVAFGGPISAGLMGIRKPAFDVYGQVVNDAQAMESGGEPMKVHINKELYDIVND 1350
>UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC
4.6.1.1) (Adenylate cyclase type VI) (ATP
pyrophosphate-lyase 6) (Adenylyl cyclase 6)
(Ca(2+)-inhibitable adenylyl cyclase).; n=2;
Coelomata|Rep: Adenylate cyclase type 6 (EC 4.6.1.1)
(Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6)
(Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl
cyclase). - Xenopus tropicalis
Length = 355
Score = 87.0 bits (206), Expect = 1e-15
Identities = 55/188 (29%), Positives = 96/188 (51%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP+ VA +A + R+++ +Y Q E V+++FA IC F+ + A E
Sbjct: 137 NILPKDVAAHF---LAREHRNDE---LYYQSCECVAVMFASICNFSEFYVELEANNEGVE 190
Query: 346 LVRLLNELFARFDRLAAEH---HCLRIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD + +E +IK +G Y SGL + D H +
Sbjct: 191 CLRLLNEIIADFDEIISEEKFKQLEKIKTIGSTYMAASGLNDTTYDKEGKTHITALADYA 250
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ + + + + E N M++G++ G V V+G RK Q+D+W N V +A+ M+S G+
Sbjct: 251 MKLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLP 310
Query: 458 GRVHITKE 465
+ +T +
Sbjct: 311 DCIQVTTD 318
>UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1112
Score = 87.0 bits (206), Expect = 1e-15
Identities = 49/179 (27%), Positives = 95/179 (53%), Gaps = 13/179 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP+ VA ++K + +P + ++ V++ F+D+ FT+++ +C+ ++V LL
Sbjct: 888 MLPKQVADKLKLGQSVEP----------ETFDCVTVFFSDVVSFTTIASKCSPLQVVNLL 937
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAKCCVEMGLDMIDAIA--LV 407
N L+ D + AE +++ +GD Y CVSGLP +HA+ +M L + + +
Sbjct: 938 NNLYTLLDSIIAEFDVYKVETIGDGYLCVSGLPHRNGHEHAQHIAKMSLAFMRNLGSFTI 997
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ + +R+GIHTG V+GL ++ ++ + + A +ES R+HI+ T
Sbjct: 998 PHLPIERLRLRIGIHTGSTVAGVVGLSMPRYCLFGDTINTAARLESSSKPMRIHISTTT 1056
>UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 987
Score = 87.0 bits (206), Expect = 1e-15
Identities = 46/155 (29%), Positives = 89/155 (57%), Gaps = 3/155 (1%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
++ + ++ V+I F+D+ GFT L Q E+V +LN+L+ D + + + +++ +GD
Sbjct: 802 RVEAENFDCVTIFFSDLVGFTELCAQSNPFEVVEMLNDLYTCCDFIISSYDVYKVETIGD 861
Query: 375 CYYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP D HA + L ++++++ +R + +R+GIH+G+ V+
Sbjct: 862 AYMVVSGLPIRNGDRHAGEIASLALHLLNSLSNLEIRHRPGEFIQIRIGIHSGQCVAGVV 921
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
GL+ ++ ++ + V A+ MES G A ++HI+ T
Sbjct: 922 GLKMPRYCLFGDTVNTASRMESTGDAMKIHISSVT 956
>UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble
guanylyl cyclase alpha 1 subunit; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to soluble guanylyl
cyclase alpha 1 subunit - Nasonia vitripennis
Length = 705
Score = 86.6 bits (205), Expect = 2e-15
Identities = 47/151 (31%), Positives = 78/151 (51%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
I + Y +V++LF+DI GFT++ T ++ +L L+ +FD + +++ +GD
Sbjct: 489 IEAKNYADVTMLFSDIVGFTAICSTATPMMVINMLQNLYQQFDSYCGQLDVYKVETIGDA 548
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL HA+ MGL MI + MR+GIHTG V V+G +
Sbjct: 549 YCVACGLHRNTSTHAQQIAWMGLKMIQTCTQHSTHDGKPIKMRIGIHTGMVLAGVVGKKM 608
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ ++VT+AN ES RV+I+ T
Sbjct: 609 PRYCLFGHNVTIANKFESSSEPLRVNISPTT 639
>UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl
cyclase 35C CG9210-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Adenylyl cyclase
35C CG9210-PA, isoform A - Apis mellifera
Length = 729
Score = 86.6 bits (205), Expect = 2e-15
Identities = 59/196 (30%), Positives = 99/196 (50%), Gaps = 16/196 (8%)
Query: 317 YIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLAAE---HHCLRIKL 371
Y Q ++ V I+FA I F L D+ +E +R+LNEL FD L + + +IK
Sbjct: 525 YSQNHKAVGIIFASIVNFNELYDESYLGGKEYLRVLNELIGDFDELLEKPEFSNVEKIKT 584
Query: 372 LGDCYYCVSGL-PEARDD------HAKCCVEMGLDMIDAIA-LVREVMAVNVNMRVGIHT 423
+G + SGL P+ R H ++ + + I R+++ + +R+G +
Sbjct: 585 IGSTFMAASGLNPQVRQQNEHEYKHLFQLIDFAMTLHKVINDFNRDLLGFKLILRIGFNY 644
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V V+G K +D+W + V +A+ M+S GVAGR+ + K L L + Y+ EP Y
Sbjct: 645 GDVTAGVIGATKLYYDIWGDAVNIASRMDSTGVAGRIQVAKNVLDVLSERYEFEPRGQVY 704
Query: 484 RNAYLKDHNIETYLIV 499
KD N++ +L++
Sbjct: 705 VKG--KD-NMDVFLLI 717
>UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep:
Guanylate cyclase - Asterias amurensis (Starfish)
Length = 1067
Score = 86.2 bits (204), Expect = 2e-15
Identities = 46/150 (30%), Positives = 83/150 (55%), Gaps = 3/150 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ ++ V+I F+DI GFT+LS T ++V LLN L+ FD + + +++ +GD Y
Sbjct: 867 EAFDMVTIFFSDIVGFTALSAASTPIQVVNLLNALYTTFDATISNYDVYKVETIGDAYML 926
Query: 379 VSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
VSGLP + HA +++ + +V + +R+GIH+G V+GL
Sbjct: 927 VSGLPLRNGNRHAGMIASAAWHLLEEVTTFVVPHKRDEKLKLRIGIHSGSCVAGVVGLTM 986
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKE 465
++ ++ + V A+ MES G+A ++H++ E
Sbjct: 987 PRYCLFGDTVNTASRMESNGLALKIHVSPE 1016
>UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1545
Score = 86.2 bits (204), Expect = 2e-15
Identities = 58/185 (31%), Positives = 94/185 (50%), Gaps = 10/185 (5%)
Query: 322 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL-RIKLLGDCYYCVS 380
++ S++F DI FT A ++ +LN L+ FD A + +IK +GDCY
Sbjct: 1365 QSASVVFMDIVSFTPWCGSLPANRVMEILNRLYKEFDAKVASFPTMTKIKCIGDCYMAAG 1424
Query: 381 GL-PEARDD--HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT-GRVHCVVLGLRKW 436
G+ E HAK VE G++ I A+ +V E ++ +RVGI+T G + VLG K
Sbjct: 1425 GIFAEINQPAVHAKEIVEFGIEAIGAVGVVNEETKQSLQIRVGINTGGPLVAGVLGSGKP 1484
Query: 437 QFDVWSNDVTLANYMESGGVAGRVHITKETL-CCLGDDYKVEPGHGGYRNAYLKDHNIET 495
F++ + +A ME GV +VHI++ G ++K++ G +K+ + T
Sbjct: 1485 TFEILGPTINMAQQMEHHGVPMQVHISRAVYELIYGGNFKIKE-RG---QIEIKNGTVVT 1540
Query: 496 YLIVP 500
YL+ P
Sbjct: 1541 YLVSP 1545
>UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8;
Endopterygota|Rep: Head-specific guanylate cyclase -
Drosophila melanogaster (Fruit fly)
Length = 676
Score = 86.2 bits (204), Expect = 2e-15
Identities = 48/146 (32%), Positives = 78/146 (53%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
Y +V+ILF+DI GFTS+ + T ++ +L L+ FD +++ +GD Y S
Sbjct: 462 YPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVAS 521
Query: 381 GLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDV 440
GL A A M L MIDA + + MR+G+HTG V V+G + ++ +
Sbjct: 522 GLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCL 581
Query: 441 WSNDVTLANYMESGGVAGRVHITKET 466
+ + VT+AN ESG A +++++ T
Sbjct: 582 FGHSVTIANKFESGSEALKINVSPTT 607
>UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl
cyclase-G; n=6; Euteleostomi|Rep: PREDICTED: similar to
guanylyl cyclase-G - Monodelphis domestica
Length = 1111
Score = 85.8 bits (203), Expect = 3e-15
Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 3/155 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+++++V+I F+DI GFT L T ++V LLN+L++ FD + + +++ +GD Y
Sbjct: 870 EQFDSVTIFFSDIVGFTKLCSLSTPLQVVGLLNDLYSLFDNIIKTYDVYKVETIGDAYMV 929
Query: 379 VSGLPEARD-DHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
SGLP H + M L + + + + +R+G+HTG V V+G+
Sbjct: 930 ASGLPLRNGIQHVEEIATMSLHFLSVVVHFKIGHKPEEKLKLRIGLHTGPVVAGVVGITM 989
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
++ ++ + V +A+ MES + R+H+++ T L
Sbjct: 990 PRYCLFGDTVNMASRMESNSLPLRIHVSQTTASAL 1024
>UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1579
Score = 85.8 bits (203), Expect = 3e-15
Identities = 50/149 (33%), Positives = 86/149 (57%), Gaps = 5/149 (3%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL-RIKLLGDCYYCVSG 381
+ SI+F DI F+ + T +E++ L+ +FA FD + ++ + +IKL+GD Y +G
Sbjct: 1381 SASIIFIDIVKFSEYAASLTPQEIMGNLSTVFAAFDEMVKKYPKITKIKLIGDVYMAAAG 1440
Query: 382 LPEARDD---HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR-VHCVVLGLRKWQ 437
L + +DD HAK V GLD + + V + ++ +R+GI+TG + VLG K
Sbjct: 1441 LFDEQDDPASHAKDMVNFGLDCLGELDEVNVKLNASLEVRIGINTGGPLLAGVLGTDKPV 1500
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET 466
FD+ + + +A ++S +AGR+ I+K T
Sbjct: 1501 FDIIGDPINIAARLQSTDIAGRIQISKAT 1529
>UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2;
Strongylocentrotidae|Rep: Soluble guanylyl cyclase beta1
- Hemicentrotus pulcherrimus (Sea urchin)
Length = 604
Score = 85.4 bits (202), Expect = 4e-15
Identities = 53/179 (29%), Positives = 100/179 (55%), Gaps = 8/179 (4%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELVRLLNELFARFDRLA 361
+A++ RH + + +++E V+++F+ I GF + + A ++V LLN ++ +FD L
Sbjct: 395 VANELRHHR--PVPAKKFECVTLMFSGIFGFGDFCRRYSHDAMKIVSLLNSVYTKFDVLM 452
Query: 362 AEH-HCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN-VNMRV 419
+ +++ +GD Y VSGLP DHAKC +M L+M + A V +M + + + +
Sbjct: 453 ENNPDVYKVETVGDKYMAVSGLPVPCADHAKCIAKMALEMKELSADV--IMEGDPIVITI 510
Query: 420 GIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEP 478
G+++G V V+G R ++ ++ N V L + E+ GV G+++I CL + +P
Sbjct: 511 GVYSGEVVTGVVGQRMPRYCLFGNTVNLTSRTETTGVTGKINIADTAYDCLMEPQNADP 569
>UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=6; cellular organisms|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1529
Score = 85.4 bits (202), Expect = 4e-15
Identities = 52/161 (32%), Positives = 84/161 (52%), Gaps = 6/161 (3%)
Query: 323 NVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL-RIKLLGDCYYCVSG 381
+ +I+F DI FT TA+ + LN++F FD + + RIK +GDCY G
Sbjct: 1349 SATIVFIDIVEFTPWCSSNTAQVVTGTLNDIFTEFDTIIESLPVMERIKCIGDCYMAAGG 1408
Query: 382 L-PEARD--DHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT-GRVHCVVLGLRKWQ 437
+ E + A+ V+ GLD I AI V E +++ +RVG+H G + V+G K
Sbjct: 1409 IFAETPNVLQFARAAVDFGLDAIAAIGRVNEKHGMSLRVRVGVHIGGPIVAGVIGTGKPT 1468
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETL-CCLGDDYKVE 477
F+++ +++A ME GV +VH+++ G YK+E
Sbjct: 1469 FEIFGPAISMAQQMEHNGVPMKVHVSRSIYELIYGGTYKIE 1509
>UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|Rep:
Guanylate cyclase - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 859
Score = 85.0 bits (201), Expect = 5e-15
Identities = 53/184 (28%), Positives = 92/184 (50%), Gaps = 13/184 (7%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
S+LP+ VA +++ SQ Q Y + ++ F+DI GFT LS T ++V
Sbjct: 613 SMLPKQVADDLRQGKPSQA----------QSYVSATVFFSDIVGFTQLSSSSTPYQVVDF 662
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDD-HAKCCVEMGLDMIDAIALVR 408
LN+L+ FD + + +++ +GD Y VSG+P+ HA M LD++ R
Sbjct: 663 LNKLYTTFDNIIDNYDVYKVETIGDAYMVVSGVPQENGILHASEIASMALDLVGVCRTFR 722
Query: 409 --EVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ + +R GIH+G V V+G + ++ ++ + V A+ MES A ++ + T
Sbjct: 723 IPHKPSMQLQIRAGIHSGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSTALKIQCSSST 782
Query: 467 LCCL 470
L
Sbjct: 783 FYLL 786
>UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theileria
annulata|Rep: Cation-transporting ATPase - Theileria
annulata
Length = 2559
Score = 85.0 bits (201), Expect = 5e-15
Identities = 54/195 (27%), Positives = 99/195 (50%), Gaps = 10/195 (5%)
Query: 311 EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 370
E+ YI +E++S LF+DI GFT ++ E++ LL +LFA FDR + ++
Sbjct: 2344 ERLKMCYI--HEHMSFLFSDIVGFTKWAESVDPSEVIALLQKLFANFDRNTTNFNLYKLC 2401
Query: 371 LLGDCYYCVSGLPEARDDH------AKCCVEMGLDMIDAIALVREVMAV-NVNMRVGIHT 423
+GD Y +S P+ D+ + + M MI I ++ + ++ MR+G+H
Sbjct: 2402 TIGDAYVAISE-PKVIDNQDMRIKDLENILLMAYSMIHIIDETSKIFNIPDLKMRIGLHY 2460
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V+G + ++DVW DV AN +ES GV G V ++++ + + +
Sbjct: 2461 GSCIGGVIGSGRLRYDVWGTDVYTANMIESNGVPGEVCVSEKFRDIISQHFPNRFKFEHH 2520
Query: 484 RNAYLKDHNIETYLI 498
++ + D I++++I
Sbjct: 2521 KDINIIDKTIKSFII 2535
Score = 49.6 bits (113), Expect = 2e-04
Identities = 22/64 (34%), Positives = 37/64 (57%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+R+ENV+++FAD+ F L LV +L+ LF FDR + E + ++I+ + + Y
Sbjct: 1661 ERHENVTVIFADVYNFQELIATIEPHRLVEILDTLFLSFDRCSKEFNAIKIETVSETYLT 1720
Query: 379 VSGL 382
GL
Sbjct: 1721 SMGL 1724
Score = 41.9 bits (94), Expect = 0.044
Identities = 20/88 (22%), Positives = 49/88 (55%)
Query: 390 AKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLAN 449
A ++M + M+ ++ ++ +++GI++G V ++G +K Q+ ++ + V A+
Sbjct: 1782 ASSSLDMSIAMLQVATTIKLNNNESIGVKIGINSGYVISGLVGSKKPQYALFGDTVNTAS 1841
Query: 450 YMESGGVAGRVHITKETLCCLGDDYKVE 477
M+ G G++HI++ T + +D +E
Sbjct: 1842 RMKMTGEVGKIHISESTYELVKNDKTLE 1869
>UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 918
Score = 85.0 bits (201), Expect = 5e-15
Identities = 53/172 (30%), Positives = 94/172 (54%), Gaps = 13/172 (7%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH--------HC--LR 368
Q ++ V+ILF+ + GF L +A E+V ++N +F FD+L+ +H HC L+
Sbjct: 705 QHFDCVTILFSYLDGFVQLCSHVSAMEVVSVVNTMFTVFDKLSEKHDVYKAFDLHCSILK 764
Query: 369 IKLLGDC-YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMA-VNVNMRVGIHTGRV 426
+ LGD Y VSG P + HA+ M LDMIDA+ +++ + + + +G+H+G V
Sbjct: 765 FETLGDAIYMAVSGAPVPKARHAEPMAAMALDMIDAMDEIKKFCSNALLTITIGMHSGAV 824
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE-TLCCLGDDYKVE 477
V+G R Q+ ++ + V +A+ + + + R+HI+ C L ++ E
Sbjct: 825 VAGVVGKRTPQYCLFGHTVNIASRLRTTALPMRIHISNSCNECLLNTEFHTE 876
>UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1113
Score = 84.6 bits (200), Expect = 6e-15
Identities = 53/178 (29%), Positives = 91/178 (51%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP +VA E+K + P+ Y + +ILF+DI GFT++ T E+V +L
Sbjct: 894 LLPAYVANELKMGRSVAPK----------LYSSATILFSDIVGFTTICSGSTPLEVVNML 943
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARD-DHAKCCVEMGLDMIDAIA--LV 407
N L+ FD + +++ +GD Y VSG+PE + +H++ LDM + +
Sbjct: 944 NGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQI 1003
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V R G HTG V V+GL ++ ++ + V +++ MES G G + +++E
Sbjct: 1004 PHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEE 1061
>UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3;
Diptera|Rep: Guanylate cyclase 32E precursor - Drosophila
melanogaster (Fruit fly)
Length = 1163
Score = 84.2 bits (199), Expect = 8e-15
Identities = 45/149 (30%), Positives = 83/149 (55%), Gaps = 3/149 (2%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V+ILF+DI GFT L T E+V +LN+ + D + + + +++ +GD Y VS
Sbjct: 869 FDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVS 928
Query: 381 GLP-EARDDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP + HA + L +++ + +R V +R+G+H+G V+G + +
Sbjct: 929 GLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPR 988
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET 466
+ ++ + V A+ MES G + R+HI++ T
Sbjct: 989 YCLFGDTVNTASRMESTGDSMRIHISEAT 1017
>UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to
ENSANGP00000003998; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000003998 - Nasonia
vitripennis
Length = 643
Score = 83.8 bits (198), Expect = 1e-14
Identities = 42/160 (26%), Positives = 88/160 (55%), Gaps = 2/160 (1%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ +E++S+LF ++C F + + A ++V +N +++ FD L + + +++ +G Y
Sbjct: 432 ESFESISVLFCELCDFNYSTIE-GAMDIVSSMNAVYSCFDSLMDKFNVYKVETVGRVYMA 490
Query: 379 VSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQF 438
SG P+ DDHA ++ L +I + + + + +R+GIH+G V+G++ ++
Sbjct: 491 ASGAPDRTDDHAINVADVSLQLISQVRSLVLPSGLEIQIRIGIHSGPAVAGVVGIKVPRY 550
Query: 439 DVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD-YKVE 477
+ + V A+ M++ + G+VHI+ T L D Y +E
Sbjct: 551 CFFGDTVNTASRMQTTSLPGKVHISPHTRALLPQDRYVIE 590
>UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1;
Erythrobacter sp. NAP1|Rep: Adenylate/guanylate cyclase
- Erythrobacter sp. NAP1
Length = 420
Score = 83.8 bits (198), Expect = 1e-14
Identities = 43/152 (28%), Positives = 78/152 (51%)
Query: 315 KIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGD 374
++ + +VS++F DI GF+ L+ + + LV+LLN +F D A ++K +GD
Sbjct: 228 EVVADSFSDVSVVFVDIVGFSKLARKLSPGHLVKLLNAIFGLADECAKNAGVEKVKTIGD 287
Query: 375 CYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
Y V+G + ++ A + MI A+ ++V +RVGIHTG V V+G +
Sbjct: 288 AYLAVAGGTTSTENDAVSAIRFAEQMIAAVTDYARETRIDVAIRVGIHTGPVVGGVIGQQ 347
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+ +D W + + A +E G + +++ T
Sbjct: 348 RMAYDYWGDTMNTAARLEGVAKPGGIAVSEST 379
>UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1073
Score = 83.8 bits (198), Expect = 1e-14
Identities = 48/178 (26%), Positives = 97/178 (54%), Gaps = 13/178 (7%)
Query: 291 VLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+LP++VA E+K + + ++ +++F+DI GFT++ T E+V +L
Sbjct: 854 LLPKYVANELKMG----------RSVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSML 903
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEAR-DDHAK--CCVEMGLDMIDAIALV 407
N ++++FD +H +++ +GD Y VSG+PE ++H + C + L ++ +
Sbjct: 904 NSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEI 963
Query: 408 REVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKE 465
V + +R+GIHTG V V+GL ++ ++ + V +A+ MES ++ +++E
Sbjct: 964 PHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQE 1021
>UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1280
Score = 83.8 bits (198), Expect = 1e-14
Identities = 45/152 (29%), Positives = 84/152 (55%), Gaps = 4/152 (2%)
Query: 319 QRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 378
+ + V+I F+DI GFT++S + T E+V LN+L+ FD + + +++ +GD Y
Sbjct: 1021 EAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMV 1080
Query: 379 VSGLPEAR--DDHAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLGLR 434
VSG+P+ + + HA+ M + ++ A+ + + +R+G+HTG V+G
Sbjct: 1081 VSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKT 1140
Query: 435 KWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
++ ++ + V A+ MES G A R+H + T
Sbjct: 1141 MPRYTLFGDTVNTASRMESNGEALRIHCSSST 1172
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.325 0.137 0.418
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 564,412,445
Number of Sequences: 1657284
Number of extensions: 21292968
Number of successful extensions: 59530
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 490
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 58133
Number of HSP's gapped (non-prelim): 893
length of query: 566
length of database: 575,637,011
effective HSP length: 105
effective length of query: 461
effective length of database: 401,622,191
effective search space: 185147830051
effective search space used: 185147830051
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 75 (34.3 bits)
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