Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002064-TA|BGIBMGA002064-PA|IPR001054|Adenylyl cyclase
class-3/4/guanylyl cyclase
(566 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein. 412 e-114
AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type V... 412 e-114
AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein. 412 e-114
AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type ... 391 e-108
AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase... 354 4e-97
Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein. 339 1e-92
DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase... 333 1e-90
L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein. 305 2e-82
BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3 pro... 291 6e-78
AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein. 291 6e-78
AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cycla... 290 8e-78
BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2 (br... 287 7e-77
AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein. 287 9e-77
D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein. 286 2e-76
BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7 pro... 286 2e-76
AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type I... 282 2e-75
AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein. 279 2e-74
BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4 pro... 274 7e-73
BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4 pro... 274 7e-73
AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type ... 274 7e-73
BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein. 248 4e-65
DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9... 198 3e-50
DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9... 198 3e-50
AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type ... 198 3e-50
AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type I... 198 3e-50
AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein. 198 3e-50
AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type I... 195 3e-49
AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein. 163 1e-39
U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V p... 149 2e-35
AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens ... 114 9e-25
Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase ... 104 1e-21
U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase... 104 1e-21
AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cycla... 104 1e-21
BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein. 103 2e-21
X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble... 101 9e-21
BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1, so... 101 9e-21
BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1, so... 101 9e-21
X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein... 100 3e-20
S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptid... 100 3e-20
BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide rec... 100 3e-20
AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide rec... 100 3e-20
AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide rec... 100 3e-20
AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide rec... 100 3e-20
AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A t... 100 3e-20
M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein. 99 4e-20
AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein. 99 4e-20
AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclas... 99 4e-20
X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein. 98 6e-20
BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1, so... 98 6e-20
BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein. 98 6e-20
AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide re... 98 6e-20
AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic pept... 98 6e-20
L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein. 98 8e-20
AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F, r... 98 8e-20
M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V p... 96 3e-19
X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein. 94 1e-18
AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens ... 93 3e-18
S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled... 92 4e-18
M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin r... 92 4e-18
U65474-1|AAD00122.1| 74|Homo sapiens adenylyl cyclase type VI ... 81 1e-14
AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cycla... 81 1e-14
X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein. 80 2e-14
L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein. 80 2e-14
AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein. 80 2e-14
AJ005282-1|CAA06466.1| 995|Homo sapiens NPR-Bi protein. 77 2e-13
AF497515-1|AAM94372.1| 301|Homo sapiens adenylate cyclase type ... 76 4e-13
AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens ... 73 3e-12
AL160157-1|CAI15432.2| 385|Homo sapiens guanylate cyclase 1, so... 67 1e-10
Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of solubl... 67 2e-10
BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein. 58 6e-08
>BC064923-1|AAH64923.1| 1168|Homo sapiens ADCY6 protein protein.
Length = 1168
Score = 412 bits (1014), Expect = e-114
Identities = 204/383 (53%), Positives = 260/383 (67%), Gaps = 3/383 (0%)
Query: 130 VIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTG 189
V +L +A +F L+ +R + + + +SYVVL ++ A + RS +
Sbjct: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
Query: 190 ACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM---QLYCTIATLIACN 246
F Y+ Y LP+R+ A + GL L+ +++ L+ QL + + N
Sbjct: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
Query: 247 AAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS 306
G+ TH P E++QR+AF ETR ++A SVLP+HVAMEMK DI +
Sbjct: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
Query: 307 QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC 366
+ FHKIYIQ+++NVSILFADI GFTSL+ QCTA+ELV LNELFARFD+LAAE+HC
Sbjct: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
Query: 367 LRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRV 426
LRIK+LGDCYYCVSGLPEAR DHA CCVEMG+DMI+AI+LVREV VNVNMRVGIH+GRV
Sbjct: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNA 486
HC VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HIT+ TL L DY+VEPG GG RNA
Sbjct: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
Query: 487 YLKDHNIETYLIVPDDTSRVDKK 509
YLK+ +IET+LI+ R ++K
Sbjct: 541 YLKEQHIETFLILGASQKRKEEK 563
Score = 86.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 97/188 (51%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP+ VA +A + R+++ +Y Q E V+++FA I F+ + A E
Sbjct: 950 NILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASIANFSEFYVELEANNEGVE 1003
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD + +E +IK +G Y SGL + D H +
Sbjct: 1004 CLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYA 1063
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ +++ + + E N M++G++ G V V+G RK Q+D+W N V +++ M+S GV
Sbjct: 1064 MRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1123
Query: 458 GRVHITKE 465
R+ +T +
Sbjct: 1124 DRIQVTTD 1131
Score = 32.7 bits (71), Expect = 3.6
Identities = 12/20 (60%), Positives = 18/20 (90%)
Query: 21 SKVEMLYQRYFLRMNQTNMT 40
+K+E LYQRYF +MNQ+++T
Sbjct: 134 AKLERLYQRYFFQMNQSSLT 153
>AF250226-1|AAF82478.1| 1168|Homo sapiens adenylyl cyclase type VI
protein.
Length = 1168
Score = 412 bits (1014), Expect = e-114
Identities = 204/383 (53%), Positives = 260/383 (67%), Gaps = 3/383 (0%)
Query: 130 VIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTG 189
V +L +A +F L+ +R + + + +SYVVL ++ A + RS +
Sbjct: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
Query: 190 ACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM---QLYCTIATLIACN 246
F Y+ Y LP+R+ A + GL L+ +++ L+ QL + + N
Sbjct: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
Query: 247 AAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS 306
G+ TH P E++QR+AF ETR ++A SVLP+HVAMEMK DI +
Sbjct: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
Query: 307 QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC 366
+ FHKIYIQ+++NVSILFADI GFTSL+ QCTA+ELV LNELFARFD+LAAE+HC
Sbjct: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
Query: 367 LRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRV 426
LRIK+LGDCYYCVSGLPEAR DHA CCVEMG+DMI+AI+LVREV VNVNMRVGIH+GRV
Sbjct: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNA 486
HC VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HIT+ TL L DY+VEPG GG RNA
Sbjct: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
Query: 487 YLKDHNIETYLIVPDDTSRVDKK 509
YLK+ +IET+LI+ R ++K
Sbjct: 541 YLKEQHIETFLILGASQKRKEEK 563
Score = 86.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 97/188 (51%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP+ VA +A + R+++ +Y Q E V+++FA I F+ + A E
Sbjct: 950 NILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASIANFSEFYVELEANNEGVE 1003
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD + +E +IK +G Y SGL + D H +
Sbjct: 1004 CLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYA 1063
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ +++ + + E N M++G++ G V V+G RK Q+D+W N V +++ M+S GV
Sbjct: 1064 MRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1123
Query: 458 GRVHITKE 465
R+ +T +
Sbjct: 1124 DRIQVTTD 1131
Score = 32.7 bits (71), Expect = 3.6
Identities = 12/20 (60%), Positives = 18/20 (90%)
Query: 21 SKVEMLYQRYFLRMNQTNMT 40
+K+E LYQRYF +MNQ+++T
Sbjct: 134 AKLERLYQRYFFQMNQSSLT 153
>AB007882-1|BAA24852.2| 1160|Homo sapiens KIAA0422 protein.
Length = 1160
Score = 412 bits (1014), Expect = e-114
Identities = 204/383 (53%), Positives = 260/383 (67%), Gaps = 3/383 (0%)
Query: 130 VIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTG 189
V +L +A +F L+ +R + + + +SYVVL ++ A + RS +
Sbjct: 226 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 285
Query: 190 ACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDM---QLYCTIATLIACN 246
F Y+ Y LP+R+ A + GL L+ +++ L+ QL + + N
Sbjct: 286 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 345
Query: 247 AAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS 306
G+ TH P E++QR+AF ETR ++A SVLP+HVAMEMK DI +
Sbjct: 346 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 405
Query: 307 QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC 366
+ FHKIYIQ+++NVSILFADI GFTSL+ QCTA+ELV LNELFARFD+LAAE+HC
Sbjct: 406 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 465
Query: 367 LRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRV 426
LRIK+LGDCYYCVSGLPEAR DHA CCVEMG+DMI+AI+LVREV VNVNMRVGIH+GRV
Sbjct: 466 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 525
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNA 486
HC VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HIT+ TL L DY+VEPG GG RNA
Sbjct: 526 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 585
Query: 487 YLKDHNIETYLIVPDDTSRVDKK 509
YLK+ +IET+LI+ R ++K
Sbjct: 586 YLKEQHIETFLILGASQKRKEEK 608
Score = 86.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 97/188 (51%), Gaps = 18/188 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP+ VA +A + R+++ +Y Q E V+++FA I F+ + A E
Sbjct: 942 NILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASIANFSEFYVELEANNEGVE 995
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEARDD-----HAKCCVEMG 397
+RLLNE+ A FD + +E +IK +G Y SGL + D H +
Sbjct: 996 CLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYA 1055
Query: 398 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVA 457
+ +++ + + E N M++G++ G V V+G RK Q+D+W N V +++ M+S GV
Sbjct: 1056 MRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1115
Query: 458 GRVHITKE 465
R+ +T +
Sbjct: 1116 DRIQVTTD 1123
Score = 32.7 bits (71), Expect = 3.6
Identities = 12/20 (60%), Positives = 18/20 (90%)
Query: 21 SKVEMLYQRYFLRMNQTNMT 40
+K+E LYQRYF +MNQ+++T
Sbjct: 179 AKLERLYQRYFFQMNQSSLT 198
>AF497517-1|AAM94374.1| 894|Homo sapiens adenylate cyclase type V
protein.
Length = 894
Score = 391 bits (963), Expect = e-108
Identities = 184/276 (66%), Positives = 216/276 (78%)
Query: 234 QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLP 293
QL + N G+ TH P E++QR+AF ETR+C++A SVLP
Sbjct: 11 QLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP 70
Query: 294 RHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNEL 353
RHVAMEMKADI ++ FHKIYIQ+++NVSILFADI GFTSL+ QCTA+ELV LNEL
Sbjct: 71 RHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 130
Query: 354 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAV 413
FARFD+LAAE+HCLRIK+LGDCYYCVSGLPEAR DHA CCVEMG+DMI+AI+LVREV V
Sbjct: 131 FARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGV 190
Query: 414 NVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDD 473
NVNMRVGIH+GRVHC VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HITK TL L D
Sbjct: 191 NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGD 250
Query: 474 YKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
Y+VEPG GG RNAYLK+H+IET+LI+ R ++K
Sbjct: 251 YEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEK 286
Score = 95.1 bits (226), Expect = 6e-19
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 20/277 (7%)
Query: 215 ALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAAGMLTH-QPRELAQRRAFLETRDCVEA 273
A+ N G ++++ + L +I+ + H Q E R FL E
Sbjct: 599 AIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE 658
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICG 333
++LP+ VA +A + R+++ +Y Q E V+++FA I
Sbjct: 659 KEEMEELQAYNRRLLHNILPKDVAAHF---LARERRNDE---LYYQSCECVAVMFASIAN 712
Query: 334 FTSLSDQCTAE----ELVRLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGLPEAR 386
F+ + A E +RLLNE+ A FD + +E +IK +G Y SGL ++
Sbjct: 713 FSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDST 772
Query: 387 DD-----HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVW 441
D H K + + ++D + + E N M++G++ G V V+G RK Q+D+W
Sbjct: 773 YDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW 832
Query: 442 SNDVTLANYMESGGVAGRVHITKETLCCL-GDDYKVE 477
N V +A+ M+S GV R+ +T + L + Y++E
Sbjct: 833 GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLE 869
>AB209496-1|BAD92733.1| 1045|Homo sapiens brain adenylate cyclase 1
variant protein.
Length = 1045
Score = 354 bits (871), Expect = 4e-97
Identities = 186/382 (48%), Positives = 238/382 (62%), Gaps = 13/382 (3%)
Query: 137 ALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRS------LTVSTGA 190
AL+ + L P + ++ L + + + A L F+ G + + T G
Sbjct: 91 ALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGV 150
Query: 191 CSLF--TYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIA 244
L T+V+YA LPVR A GL +AA ++ L + +L+ T+ +
Sbjct: 151 WQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVG 210
Query: 245 CNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI 304
N G+ E +QR+AFL+ R C+E S+LPR+VAMEMK D
Sbjct: 211 VNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF 270
Query: 305 ASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 364
P FHKIYIQR++NVSILFADI GFT L+ QCTA+ELV+LLNELF +FD LA E+
Sbjct: 271 LKPPERI-FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATEN 329
Query: 365 HCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 424
HC RIK+LGDCYYCVSGL + + DHA CCVEMGLDMID I V E V++NMRVG+HTG
Sbjct: 330 HCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTG 389
Query: 425 RVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYR 484
RV C VLGLRKWQ+DVWSNDVTLAN ME+ G+ G+VHITK TL CL DY+VEPG+G R
Sbjct: 390 RVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHER 449
Query: 485 NAYLKDHNIETYLIVPDDTSRV 506
N++LK HNIET+ IVP ++
Sbjct: 450 NSFLKTHNIETFFIVPSHRRKI 471
Score = 86.2 bits (204), Expect = 3e-16
Identities = 59/191 (30%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 826 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVE 879
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP--------EARDDHAKCCV 394
+RLLNE+ A FD L + +IK +G Y GL ++ H
Sbjct: 880 CLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLA 939
Query: 395 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESG 454
+ ++M D + + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S
Sbjct: 940 DFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDST 999
Query: 455 GVAGRVHITKE 465
GV GR+ +T+E
Sbjct: 1000 GVQGRIQVTEE 1010
>Z35309-1|CAA84552.1| 1251|Homo sapiens adenylyl cyclase protein.
Length = 1251
Score = 339 bits (834), Expect = 1e-92
Identities = 175/319 (54%), Positives = 216/319 (67%), Gaps = 8/319 (2%)
Query: 193 LFT-YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIA--TLIAC-NAA 248
LFT + TY+ LP+ L A + GL + + + +++ + + + +A L C N A
Sbjct: 275 LFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTA 334
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS-Q 307
G+ + AQR+AFLETR CVEA SVLPR V +EM D+ + +
Sbjct: 335 GIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE 394
Query: 308 PRH--EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHH 365
H QFH+IYI RYENVSILFAD+ GFT+LS +A+ELVR+LNELFARFDRLA EHH
Sbjct: 395 DEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHH 454
Query: 366 CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR 425
CLRIK+LGDCYYCVSGLPE R DHA CCVEMGL MI I VR +V+MR+GIH+G
Sbjct: 455 CLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGS 514
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRN 485
V C VLGLRKWQFDVWS DV +AN +ESGG+ GR+HI+K TL CL DY VE GHG RN
Sbjct: 515 VLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERN 574
Query: 486 AYLKDHNIETYLI-VPDDT 503
+L+ HNIETYLI P+D+
Sbjct: 575 EFLRKHNIETYLIKQPEDS 593
Score = 95.9 bits (228), Expect = 3e-19
Identities = 65/196 (33%), Positives = 97/196 (49%), Gaps = 19/196 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + R + ++Y Q Y+ V ++FA I GF Q E
Sbjct: 953 NILPSHVARHF----LEKDRDNE--ELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVE 1006
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-PEARD-----DHAKCCVEM 396
+RLLNE+ A FD L E +IK +G Y VSGL PE + H +
Sbjct: 1007 CLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADF 1066
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L + ++I + + N +R+GI G V V+G +K Q+D+W V LA+ M+S GV
Sbjct: 1067 SLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV 1126
Query: 457 AGRVHITKETLCCLGD 472
+GR+ + +ET L D
Sbjct: 1127 SGRIQVPEETYLILKD 1142
>DQ104739-1|AAZ13596.1| 1120|Homo sapiens brain adenylate cyclase 8
protein.
Length = 1120
Score = 333 bits (818), Expect = 1e-90
Identities = 173/319 (54%), Positives = 213/319 (66%), Gaps = 8/319 (2%)
Query: 193 LFT-YVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIA--TLIAC-NAA 248
LFT + TY LP+ L A + GL + + + +++ + + + +A L C N A
Sbjct: 275 LFTLFATYGMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINRVVAQAVLFMCMNTA 334
Query: 249 GMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIAS-Q 307
G+ + AQR+AFLETR CVEA SVLPR V +EM D+ + +
Sbjct: 335 GIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE 394
Query: 308 PRH--EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHH 365
H QFH+IYI RYENVSILFAD+ GFT+LS +A+ELVR+LNELFARFDRL EHH
Sbjct: 395 DGHLQHQFHRIYIHRYENVSILFADVKGFTNLSATLSAQELVRMLNELFARFDRLVHEHH 454
Query: 366 CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR 425
CLRIK+LGDCYYCVSGLPE R DHA CCVEMGL MI I VR +V+MR+GIH+G
Sbjct: 455 CLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGS 514
Query: 426 VHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRN 485
V C VLGLRKWQFDVWS DV +AN +ESGG+ GR+HI++ TL CL DY VE GHG RN
Sbjct: 515 VLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISEATLDCLNGDYNVEEGHGKERN 574
Query: 486 AYLKDHNIETYLI-VPDDT 503
+L HNIETYLI P+D+
Sbjct: 575 EFLGKHNIETYLIKQPEDS 593
Score = 93.9 bits (223), Expect = 1e-18
Identities = 63/196 (32%), Positives = 95/196 (48%), Gaps = 19/196 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + + ++Y Q Y+ V ++FA I GF Q E
Sbjct: 822 NILPSHVARHFLE------KDQDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVE 875
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSG-LPEARD-----DHAKCCVEM 396
+RLLNE+ A FD L E +IK +G Y VSG PE + H +
Sbjct: 876 CLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGPSPEKQQCEDKWGHLCALADF 935
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L + ++I + + N +R+GI G V V+G +K Q+D+W V LA+ M+S GV
Sbjct: 936 SLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV 995
Query: 457 AGRVHITKETLCCLGD 472
+GR+ + +ET L D
Sbjct: 996 SGRIQVPEETYLILKD 1011
>L05500-1|AAA02907.1| 839|Homo sapiens adenylyl cyclase protein.
Length = 839
Score = 305 bits (750), Expect = 2e-82
Identities = 136/200 (68%), Positives = 161/200 (80%)
Query: 307 QPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC 366
+P FHKIYIQR++NVSILFADI GFT L+ QCTA+ELV+LLNELF +FD LA E+HC
Sbjct: 5 KPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHC 64
Query: 367 LRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRV 426
RIK+LGDCYYCVSGL + + DHA CCVEMGLDMID I V E V++NMRVG+HTGRV
Sbjct: 65 RRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRV 124
Query: 427 HCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNA 486
C VLGLRKWQ+DVWSNDVTLAN ME+ G+ G+VHITK TL CL DY+VEPG+G RN+
Sbjct: 125 LCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNS 184
Query: 487 YLKDHNIETYLIVPDDTSRV 506
+LK HNIET+ IVP ++
Sbjct: 185 FLKTHNIETFFIVPSHRRKI 204
Score = 86.2 bits (204), Expect = 3e-16
Identities = 59/191 (30%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTS----LSDQCTAEE 345
++LP HVA + S PR+ +Y Q Y V ++FA I F L E
Sbjct: 559 NLLPAHVAQHF---LMSNPRNMD---LYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVE 612
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLP--------EARDDHAKCCV 394
+RLLNE+ A FD L + +IK +G Y GL ++ H
Sbjct: 613 CLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLA 672
Query: 395 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESG 454
+ ++M D + + + +RVGI+ G V V+G R+ Q+D+W N V +A+ M+S
Sbjct: 673 DFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDST 732
Query: 455 GVAGRVHITKE 465
GV GR+ +T+E
Sbjct: 733 GVQGRIQVTEE 743
>BC126235-1|AAI26236.1| 1144|Homo sapiens adenylate cyclase 3
protein.
Length = 1144
Score = 291 bits (713), Expect = 6e-78
Identities = 158/390 (40%), Positives = 231/390 (59%), Gaps = 18/390 (4%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAM--NEIYLLTISYVVLVAFLLIEFSFAGTSVLRSL 184
+ ++ V G+ LV +L L + + + + + YV+ + FS+ G + R+
Sbjct: 105 LASLAVAGIG-LVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAH 163
Query: 185 TVS--TGACSLFTYVTYATLPVRLHEATIGGLALAAVN---IGAHLLLDNSSDM------ 233
S G F + + TLP+ L I + V+ +G + ++
Sbjct: 164 AASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLL 223
Query: 234 -QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVL 292
++ + + A G++++ + R+AFLE R +E S+L
Sbjct: 224 REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283
Query: 293 PRHVAMEMKADIA---SQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
P+HVA EM D+ SQ +QF+ +Y+ R+ENVSILFADI GFT LS C+A+ELV+L
Sbjct: 284 PKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKL 343
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ R+DHA C + MGL M++AI+ VRE
Sbjct: 344 LNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVRE 403
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
V+MRVG+HTG V VLG ++WQ+DVWS DVT+AN ME+GG+ GRVHI++ T+ C
Sbjct: 404 KTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDC 463
Query: 470 LGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
L ++ VEPG GG R YL++ IETYLI+
Sbjct: 464 LKGEFDVEPGDGGSRCDYLEEKGIETYLII 493
Score = 72.9 bits (171), Expect = 3e-12
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 894 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 948 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 1008 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1067
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 1068 VNVASRMESTGVMGNIQVVEET 1089
>AC012073-2|AAY14787.1| 1144|Homo sapiens unknown protein.
Length = 1144
Score = 291 bits (713), Expect = 6e-78
Identities = 158/390 (40%), Positives = 231/390 (59%), Gaps = 18/390 (4%)
Query: 127 IINVIVLGLSALVFACLLACLSRPAM--NEIYLLTISYVVLVAFLLIEFSFAGTSVLRSL 184
+ ++ V G+ LV +L L + + + + + YV+ + FS+ G + R+
Sbjct: 105 LASLAVAGIG-LVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAH 163
Query: 185 TVS--TGACSLFTYVTYATLPVRLHEATIGGLALAAVN---IGAHLLLDNSSDM------ 233
S G F + + TLP+ L I + V+ +G + ++
Sbjct: 164 AASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLL 223
Query: 234 -QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVL 292
++ + + A G++++ + R+AFLE R +E S+L
Sbjct: 224 REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283
Query: 293 PRHVAMEMKADIA---SQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRL 349
P+HVA EM D+ SQ +QF+ +Y+ R+ENVSILFADI GFT LS C+A+ELV+L
Sbjct: 284 PKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKL 343
Query: 350 LNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVRE 409
LNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ R+DHA C + MGL M++AI+ VRE
Sbjct: 344 LNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVRE 403
Query: 410 VMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCC 469
V+MRVG+HTG V VLG ++WQ+DVWS DVT+AN ME+GG+ GRVHI++ T+ C
Sbjct: 404 KTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDC 463
Query: 470 LGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
L ++ VEPG GG R YL++ IETYLI+
Sbjct: 464 LKGEFDVEPGDGGSRCDYLEEKGIETYLII 493
Score = 72.9 bits (171), Expect = 3e-12
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 894 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 948 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 1008 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1067
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 1068 VNVASRMESTGVMGNIQVVEET 1089
>AF033861-1|AAD13403.1| 1144|Homo sapiens type III adenylyl cyclase
protein.
Length = 1144
Score = 290 bits (712), Expect = 8e-78
Identities = 152/355 (42%), Positives = 216/355 (60%), Gaps = 15/355 (4%)
Query: 160 ISYVVLVAFLLIEFSFAGTSVLRSLTVS--TGACSLFTYVTYATLPVRLHEATIGGLALA 217
+ YV+ + FS+ G + R+ S G F + + TLP+ L I +
Sbjct: 139 LPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSC 198
Query: 218 AVN---IGAHLLLDNSSDM-------QLYCTIATLIACNAAGMLTHQPRELAQRRAFLET 267
V+ +G + ++ ++ + + A G++++ + R+AFLE
Sbjct: 199 VVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEA 258
Query: 268 RDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIA---SQPRHEQFHKIYIQRYENV 324
R +E S+LP+HVA EM D+ SQ +QF+ +Y+ R+ENV
Sbjct: 259 RQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENV 318
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SILFADI GFT LS C+A+ELV+LLNELFARFD+LAA++H LRIK+LGDCYYC+ GLP+
Sbjct: 319 SILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPD 378
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R+DHA C + MGL M++AI+ VRE V+MRVG+HTG V VLG ++WQ+DVWS D
Sbjct: 379 YREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTD 438
Query: 445 VTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
VT+AN ME+GG+ GRVHI++ T+ CL ++ VEPG GG R YL++ IETYLI+
Sbjct: 439 VTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLII 493
Score = 72.9 bits (171), Expect = 3e-12
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 894 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 948 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 1008 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 1067
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 1068 VNVASRMESTGVMGNIQVVEET 1089
>BC111743-1|AAI11744.1| 1091|Homo sapiens adenylate cyclase 2
(brain) protein.
Length = 1091
Score = 287 bits (704), Expect = 7e-77
Identities = 164/412 (39%), Positives = 235/412 (57%), Gaps = 25/412 (6%)
Query: 121 KERVAHIINV-IVLGLSALVFACLLACLSRPAMNEIYLLT-ISYVVLVAFLLIEFSFAGT 178
++ VA +I V L + +F +L C+ + L + + ++ LVA + F GT
Sbjct: 73 EDHVAFLITVPTALAIFFAIF--ILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGT 130
Query: 179 SVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGG-LALAAVNIGAHLLLDNSSD----- 232
S +V Y LP + +A I L ++ I + L +
Sbjct: 131 V---SPWDQVSFFLFIIFVLYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHL 187
Query: 233 -MQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSV 291
Q+ + I N AG ELA ++ + +T +C+++ S+
Sbjct: 188 VWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSL 247
Query: 292 LPRHVAMEMKADIASQ---PRHEQ------FHKIYIQRYENVSILFADICGFTSLSDQCT 342
LP H+AMEMKA+I + P+ Q FH +Y++R+ NVSIL+ADI GFT L+ C+
Sbjct: 248 LPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCS 307
Query: 343 AEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMID 402
ELV +LNELF +FD++A E+ C+RIK+LGDCYYCVSGLP + +HAK CV+MGLDM +
Sbjct: 308 PGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCE 367
Query: 403 AIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHI 462
AI VR+ V++NMRVG+H+G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHI
Sbjct: 368 AIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 427
Query: 463 TKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSF 514
+ TL L YKVE G G R+ YLK H ++TY ++ R + PQH F
Sbjct: 428 SSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGER--RSPQHLF 477
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 858 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 911
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 912 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 971
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 972 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 1031
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 1032 DSTGVLDKIQVTEET 1046
>AB011083-1|BAA25437.1| 933|Homo sapiens KIAA0511 protein protein.
Length = 933
Score = 287 bits (703), Expect = 9e-77
Identities = 136/269 (50%), Positives = 185/269 (68%), Gaps = 3/269 (1%)
Query: 234 QLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLP 293
++ + + A G++++ + R+AFLE R +E S+LP
Sbjct: 14 EILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILP 73
Query: 294 RHVAMEMKADIA---SQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLL 350
+HVA EM D+ SQ +QF+ +Y+ R+ENVSILFADI GFT LS C+A+ELV+LL
Sbjct: 74 KHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLL 133
Query: 351 NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREV 410
NELFARFD+LAA++H LRIK+LGDCYYC+ GLP+ R+DHA C + MGL M++AI+ VRE
Sbjct: 134 NELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREK 193
Query: 411 MAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
V+MRVG+HTG V VLG ++WQ+DVWS DVT+AN ME+GG+ GRVHI++ T+ CL
Sbjct: 194 TKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL 253
Query: 471 GDDYKVEPGHGGYRNAYLKDHNIETYLIV 499
++ VEPG GG R YL++ IETYLI+
Sbjct: 254 KGEFDVEPGDGGSRCDYLEEKGIETYLII 282
Score = 72.9 bits (171), Expect = 3e-12
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 683 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 736
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 737 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 796
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 797 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 856
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 857 VNVASRMESTGVMGNIQVVEET 878
>D25538-1|BAA05021.2| 1088|Homo sapiens KIAA0037 protein.
Length = 1088
Score = 286 bits (701), Expect = 2e-76
Identities = 169/464 (36%), Positives = 243/464 (52%), Gaps = 34/464 (7%)
Query: 105 SFDDTDPSHYKRIYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVV 164
+F DPS ++ I +A ++ + LS L++ + CL R + + LLT + +V
Sbjct: 61 AFSQGDPSRHQAIL----GMAFLVLAVFAALSVLMY---VECLLRRWLRALALLTWACLV 113
Query: 165 LVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAH 224
+ ++L+ F + +V Y LP + G +A+ AV+ +H
Sbjct: 114 ALGYVLV---FDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMR----GAVAVGAVSTASH 166
Query: 225 LLLDNSS-----------DMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEA 273
LL+ S +QL + N G + A R F T C++
Sbjct: 167 LLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI 226
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHE---------QFHKIYIQRYENV 324
SVLP H++M MK I + + FH +Y++R++NV
Sbjct: 227 RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNV 286
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SIL+ADI GFT L+ C+ +ELV +LNELF +FD++A + C+RIK+LGDCYYCVSGLP
Sbjct: 287 SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 346
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
+ HA+ CV+MGLDM AI VRE V++NMRVGIH+G V C V+GLRKWQ+DVWS+D
Sbjct: 347 SLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHD 406
Query: 445 VTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
V+LAN ME+ GV GRVHIT+ TL L Y+VE GHG R+ YLK+ NI TYL++ +
Sbjct: 407 VSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 466
Query: 505 RVDKKPQHSFAVNGNVSKEMRVMXXXXXXXXXXXXXVPPAAIRH 548
+ QH G+ + +MR P A + H
Sbjct: 467 QPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNH 510
Score = 82.6 bits (195), Expect = 3e-15
Identities = 65/206 (31%), Positives = 102/206 (49%), Gaps = 25/206 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA D ++ + +H Q Y+ V ++FA + F +C E
Sbjct: 859 NVLPAHVAAHFIGDKLNE---DWYH----QSYDCVCVMFASVPDFKVFYTECDVNKEGLE 911
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEA----RDDHAKCCVEMGL 398
+RLLNE+ A FD L + +IK +G Y +GL A + + +G+
Sbjct: 912 CLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGV 971
Query: 399 DMIDAIALVREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
+ +IAL+ ++ +N +RVGI+ G V V+G RK Q+D+W N V +A+ ME
Sbjct: 972 MVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRME 1031
Query: 453 SGGVAGRVHITKETLCCL-GDDYKVE 477
S G G++ +T+ET L G Y E
Sbjct: 1032 STGELGKIQVTEETCTILQGLGYSCE 1057
>BC126271-1|AAI26272.1| 1080|Homo sapiens adenylate cyclase 7
protein.
Length = 1080
Score = 286 bits (701), Expect = 2e-76
Identities = 169/464 (36%), Positives = 243/464 (52%), Gaps = 34/464 (7%)
Query: 105 SFDDTDPSHYKRIYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVV 164
+F DPS ++ I +A ++ + LS L++ + CL R + + LLT + +V
Sbjct: 53 AFSQGDPSRHQAIL----GMAFLVLAVFAALSVLMY---VECLLRRWLRALALLTWACLV 105
Query: 165 LVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAH 224
+ ++L+ F + +V Y LP + G +A+ AV+ +H
Sbjct: 106 ALGYVLV---FDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMR----GAVAVGAVSTASH 158
Query: 225 LLLDNSS-----------DMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEA 273
LL+ S +QL + N G + A R F T C++
Sbjct: 159 LLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI 218
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHE---------QFHKIYIQRYENV 324
SVLP H++M MK I + + FH +Y++R++NV
Sbjct: 219 RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNV 278
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SIL+ADI GFT L+ C+ +ELV +LNELF +FD++A + C+RIK+LGDCYYCVSGLP
Sbjct: 279 SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 338
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
+ HA+ CV+MGLDM AI VRE V++NMRVGIH+G V C V+GLRKWQ+DVWS+D
Sbjct: 339 SLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHD 398
Query: 445 VTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTS 504
V+LAN ME+ GV GRVHIT+ TL L Y+VE GHG R+ YLK+ NI TYL++ +
Sbjct: 399 VSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 458
Query: 505 RVDKKPQHSFAVNGNVSKEMRVMXXXXXXXXXXXXXVPPAAIRH 548
+ QH G+ + +MR P A + H
Sbjct: 459 QPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNH 502
Score = 82.6 bits (195), Expect = 3e-15
Identities = 65/206 (31%), Positives = 102/206 (49%), Gaps = 25/206 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA D ++ + +H Q Y+ V ++FA + F +C E
Sbjct: 851 NVLPAHVAAHFIGDKLNE---DWYH----QSYDCVCVMFASVPDFKVFYTECDVNKEGLE 903
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGLPEA----RDDHAKCCVEMGL 398
+RLLNE+ A FD L + +IK +G Y +GL A + + +G+
Sbjct: 904 CLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGV 963
Query: 399 DMIDAIALVREVMAVN------VNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYME 452
+ +IAL+ ++ +N +RVGI+ G V V+G RK Q+D+W N V +A+ ME
Sbjct: 964 MVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRME 1023
Query: 453 SGGVAGRVHITKETLCCL-GDDYKVE 477
S G G++ +T+ET L G Y E
Sbjct: 1024 STGELGKIQVTEETCTILQGLGYSCE 1049
>AF410885-1|AAP97285.1| 1091|Homo sapiens adenylyl cyclase type II
protein.
Length = 1091
Score = 282 bits (692), Expect = 2e-75
Identities = 163/412 (39%), Positives = 237/412 (57%), Gaps = 25/412 (6%)
Query: 121 KERVAHIINV-IVLGLSALVFACLLACLSRPAMNEIYLLT-ISYVVLVAFLLIEFSFAGT 178
++ VA +I V L + +F +L C+ + L + + ++ LVA + F GT
Sbjct: 73 EDHVAFLITVPTALAIFFAIF--ILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGT 130
Query: 179 SVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGG-LALAAVNIGAHLLLDNSSDMQLYC 237
S +V Y LP + +A I L ++ I + L + + +
Sbjct: 131 V---SPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHL 187
Query: 238 TIATLIACN-----AAGMLTHQP-RELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSV 291
+A C+ G H+ ELA ++ + +T +C+++ S+
Sbjct: 188 GLADPGQCDHFHLWEPGXTNHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSL 247
Query: 292 LPRHVAMEMKADIASQ---PRHEQ------FHKIYIQRYENVSILFADICGFTSLSDQCT 342
LP H+AMEMKA+I + P+ Q FH +Y++R+ NVSIL+ADI GFT L+ C+
Sbjct: 248 LPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCS 307
Query: 343 AEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMID 402
ELV +LNELF +FD++A E+ C+RIK+LGDCYYCVSGLP + +HAK CV+MGLDM +
Sbjct: 308 PGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCE 367
Query: 403 AIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHI 462
AI VR+ V++NMRVG+H+G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHI
Sbjct: 368 AIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 427
Query: 463 TKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSF 514
+ TL L YKVE G G R+ YLK H ++TY ++ R + PQH F
Sbjct: 428 SSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGER--RSPQHLF 477
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 858 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 911
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 912 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 971
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 972 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 1031
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 1032 DSTGVLDKIQVTEET 1046
>AB028983-1|BAA83012.1| 887|Homo sapiens KIAA1060 protein protein.
Length = 887
Score = 279 bits (683), Expect = 2e-74
Identities = 134/267 (50%), Positives = 183/267 (68%), Gaps = 11/267 (4%)
Query: 257 ELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQ---PRHEQ- 312
ELA ++ + +T +C+++ S+LP H+AMEMKA+I + P+ Q
Sbjct: 9 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 68
Query: 313 -----FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 367
FH +Y++R+ NVSIL+ADI GFT L+ C+ ELV +LNELF +FD++A E+ C+
Sbjct: 69 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 128
Query: 368 RIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVH 427
RIK+LGDCYYCVSGLP + +HAK CV+MGLDM +AI VR+ V++NMRVG+H+G V
Sbjct: 129 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 188
Query: 428 CVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAY 487
C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHI+ TL L YKVE G G R+ Y
Sbjct: 189 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 248
Query: 488 LKDHNIETYLIVPDDTSRVDKKPQHSF 514
LK H ++TY ++ R + PQH F
Sbjct: 249 LKQHLVKTYFVINPKGER--RSPQHLF 273
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 654 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 707
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 708 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 767
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 768 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 827
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 828 DSTGVLDKIQVTEET 842
>BC117475-1|AAI17476.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 274 bits (671), Expect = 7e-73
Identities = 155/386 (40%), Positives = 217/386 (56%), Gaps = 16/386 (4%)
Query: 140 FACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTY 199
F+ LL SR + + +S +V VA L + +F T + S + Y
Sbjct: 72 FSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAY 131
Query: 200 ATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIAT---LIAC-NAAGMLT 252
A LP+ + +A + GLA + ++ G +L S L +A L C N AG+
Sbjct: 132 AMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYH 191
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI-------- 304
E A R F E + + S+LP ++A EMKA+I
Sbjct: 192 KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
Query: 305 ASQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
S+P FH +Y++R++ VS+L+ADI GFT L+ +C+ +ELV +LNELF +FD++A E
Sbjct: 252 GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
H C+RIK+LGDCYYCVSGLP + DHA CV MGLDM AI +R V++NMRVG+H+
Sbjct: 312 HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT TL L Y VE +
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
Query: 484 RNAYLKDHNIETYLIVPDDTSRVDKK 509
R+ YL++ TYL++ D+K
Sbjct: 432 RDPYLRELGEPTYLVIDPRAEEEDEK 457
Score = 92.7 bits (220), Expect = 3e-18
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 24/199 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + I R+E +Y Q YE V +LFA + F + E
Sbjct: 844 NVLPAHVAPQF---IGQNRRNED---LYHQSYECVCVLFASVPDFKEFYSESNINHEGLE 897
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PEARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL +A+ D + C +G
Sbjct: 898 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLG 957
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A+AL ++ +N + +RVG++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 958 TMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRM 1017
Query: 452 ESGGVAGRVHITKETLCCL 470
ES GV G++ +T+ET L
Sbjct: 1018 ESTGVLGKIQVTEETAWAL 1036
>BC117473-1|AAI17474.1| 1077|Homo sapiens adenylate cyclase 4
protein.
Length = 1077
Score = 274 bits (671), Expect = 7e-73
Identities = 155/386 (40%), Positives = 217/386 (56%), Gaps = 16/386 (4%)
Query: 140 FACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTY 199
F+ LL SR + + +S +V VA L + +F T + S + Y
Sbjct: 72 FSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAY 131
Query: 200 ATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIAT---LIAC-NAAGMLT 252
A LP+ + +A + GLA + ++ G +L S L +A L C N AG+
Sbjct: 132 AMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYH 191
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI-------- 304
E A R F E + + S+LP ++A EMKA+I
Sbjct: 192 KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
Query: 305 ASQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
S+P FH +Y++R++ VS+L+ADI GFT L+ +C+ +ELV +LNELF +FD++A E
Sbjct: 252 GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
H C+RIK+LGDCYYCVSGLP + DHA CV MGLDM AI +R V++NMRVG+H+
Sbjct: 312 HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT TL L Y VE +
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
Query: 484 RNAYLKDHNIETYLIVPDDTSRVDKK 509
R+ YL++ TYL++ D+K
Sbjct: 432 RDPYLRELGEPTYLVIDPRAEEEDEK 457
Score = 92.7 bits (220), Expect = 3e-18
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 24/199 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + I R+E +Y Q YE V +LFA + F + E
Sbjct: 844 NVLPAHVAPQF---IGQNRRNED---LYHQSYECVCVLFASVPDFKEFYSESNINHEGLE 897
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PEARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL +A+ D + C +G
Sbjct: 898 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLG 957
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A+AL ++ +N + +RVG++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 958 TMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRM 1017
Query: 452 ESGGVAGRVHITKETLCCL 470
ES GV G++ +T+ET L
Sbjct: 1018 ESTGVLGKIQVTEETAWAL 1036
>AF497516-1|AAM94373.1| 1077|Homo sapiens adenylate cyclase type IV
protein.
Length = 1077
Score = 274 bits (671), Expect = 7e-73
Identities = 155/386 (40%), Positives = 217/386 (56%), Gaps = 16/386 (4%)
Query: 140 FACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTY 199
F+ LL SR + + +S +V VA L + +F T + S + Y
Sbjct: 72 FSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAY 131
Query: 200 ATLPVRLHEATIGGLALAAVNI---GAHLLLDNSSDMQLYCTIAT---LIAC-NAAGMLT 252
A LP+ + +A + GLA + ++ G +L S L +A L C N AG+
Sbjct: 132 AMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYH 191
Query: 253 HQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI-------- 304
E A R F E + + S+LP ++A EMKA+I
Sbjct: 192 KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
Query: 305 ASQPRH-EQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 363
S+P FH +Y++R++ VS+L+ADI GFT L+ +C+ +ELV +LNELF +FD++A E
Sbjct: 252 GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
Query: 364 HHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHT 423
H C+RIK+LGDCYYCVSGLP + DHA CV MGLDM AI +R V++NMRVG+H+
Sbjct: 312 HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
Query: 424 GRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGY 483
G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT TL L Y VE +
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
Query: 484 RNAYLKDHNIETYLIVPDDTSRVDKK 509
R+ YL++ TYL++ D+K
Sbjct: 432 RDPYLRELGEPTYLVIDPRAEEEDEK 457
Score = 92.7 bits (220), Expect = 3e-18
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 24/199 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + I R+E +Y Q YE V +LFA + F + E
Sbjct: 844 NVLPAHVAPQF---IGQNRRNED---LYHQSYECVCVLFASVPDFKEFYSESNINHEGLE 897
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PEARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL +A+ D + C +G
Sbjct: 898 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLG 957
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A+AL ++ +N + +RVG++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 958 TMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRM 1017
Query: 452 ESGGVAGRVHITKETLCCL 470
ES GV G++ +T+ET L
Sbjct: 1018 ESTGVLGKIQVTEETAWAL 1036
>BC039891-1|AAH39891.1| 433|Homo sapiens ADCY7 protein protein.
Length = 433
Score = 248 bits (607), Expect = 4e-65
Identities = 145/383 (37%), Positives = 208/383 (54%), Gaps = 34/383 (8%)
Query: 105 SFDDTDPSHYKRIYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVV 164
+F DPS ++ I +A ++ + LS L++ + CL R + + LLT + +V
Sbjct: 53 AFSQGDPSRHQAIL----GMAFLVLAVFAALSVLMY---VECLLRRWLRALALLTWACLV 105
Query: 165 LVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAH 224
+ ++L+ F + +V Y LP + G +A+ AV+ +H
Sbjct: 106 ALGYVLV---FDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMR----GAVAVGAVSTASH 158
Query: 225 LLLDNSS-----------DMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEA 273
LL+ S +QL + N G + A R F T C++
Sbjct: 159 LLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI 218
Query: 274 XXXXXXXXXXXXXXXXSVLPRHVAMEMKADIASQPRHE---------QFHKIYIQRYENV 324
SVLP H++M MK I + + FH +Y++R++NV
Sbjct: 219 RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNV 278
Query: 325 SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 384
SIL+ADI GFT L+ C+ +ELV +LNELF +FD++A + C+RIK+LGDCYYCVSGLP
Sbjct: 279 SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 338
Query: 385 ARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
+ HA+ CV+MGLDM AI VRE V++NMRVGIH+G V C V+GLRKWQ+DVWS+D
Sbjct: 339 SLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHD 398
Query: 445 VTLANYMESGGVAGRVHITKETL 467
V+LAN ME+ GV GRVHIT+ TL
Sbjct: 399 VSLANRMEAAGVPGRVHITEATL 421
>DQ008441-1|AAY27880.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 198 bits (484), Expect = 3e-50
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 118/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + ++ N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1255
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1256 LSISPDI 1262
>DQ005545-1|AAY21237.1| 1353|Homo sapiens adenylyl cyclase type 9
protein.
Length = 1353
Score = 198 bits (484), Expect = 3e-50
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 118/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + ++ N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1255
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1256 LSISPDI 1262
>AY028959-1|AAK29464.1| 1353|Homo sapiens adenylate cyclase type 9
protein.
Length = 1353
Score = 198 bits (484), Expect = 3e-50
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 118/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + ++ N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1255
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1256 LSISPDI 1262
>AF036927-1|AAC24201.1| 1294|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1294
Score = 198 bits (484), Expect = 3e-50
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 66.5 bits (155), Expect = 2e-10
Identities = 48/190 (25%), Positives = 94/190 (49%), Gaps = 24/190 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIA-LVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + ++ N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET 466
R+ +++E+
Sbjct: 1203 ECRIQVSEES 1212
>AB011092-1|BAA25446.3| 1364|Homo sapiens KIAA0520 protein protein.
Length = 1364
Score = 198 bits (484), Expect = 3e-50
Identities = 96/167 (57%), Positives = 116/167 (69%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 393 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 452
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HTG V C +LG
Sbjct: 453 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILG 512
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 513 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 559
Score = 67.3 bits (157), Expect = 1e-10
Identities = 63/247 (25%), Positives = 117/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1045 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1093
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1094 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1153
Query: 398 LDMIDAIALVREVMA-VNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + M N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1154 KEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1213
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1214 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1266
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1267 LSISPDI 1273
>AJ133123-1|CAB65084.1| 1353|Homo sapiens adenylyl cyclase type IX
protein.
Length = 1353
Score = 195 bits (476), Expect = 3e-49
Identities = 95/167 (56%), Positives = 115/167 (68%)
Query: 313 FHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 372
F +Q+ E VSILFADI GFT +S +A LV LLN+LF RFDRL E C +I L
Sbjct: 382 FRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTL 441
Query: 373 GDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLG 432
GDCYYCV+G PE R DHA CC+EMGL MI AI + VNMRVG+HT V C +LG
Sbjct: 442 GDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTRTVLCGILG 501
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPG 479
+R+++FDVWSNDV LAN ME GVAG+VHI++ T L D Y++E G
Sbjct: 502 MRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 67.3 bits (157), Expect = 1e-10
Identities = 63/247 (25%), Positives = 117/247 (47%), Gaps = 34/247 (13%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCT--AEELV 347
+++P HVA ++K + Y + +++ ++FA I F+ ++ +E
Sbjct: 1034 NIIPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 348 RLLNELFARFDRLAAE---HHCLRIKLLGDCYYCVSGL--PEARD-----DHAKCCVEMG 397
R+LNEL FD L ++ +IK +G Y SGL +A+D +H + E
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 398 LDMIDAIALVREVMA-VNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
+M+ + M N +RVG + G + V+G K +D+W + V +A+ M++ GV
Sbjct: 1143 KEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 457 AGRVHITKET---LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHS 513
R+ +++E+ L +G D+ + G N K ++TYL RV PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDF----DYRGTVNVKGKG-QMKTYLYPKCTDHRV--IPQHQ 1255
Query: 514 FAVNGNV 520
+++ ++
Sbjct: 1256 LSISPDI 1262
>AC069008-1|AAS07467.1| 105|Homo sapiens unknown protein.
Length = 105
Score = 163 bits (396), Expect = 1e-39
Identities = 74/105 (70%), Positives = 84/105 (80%), Gaps = 1/105 (0%)
Query: 300 MKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDR 359
MK D P FHKIYIQR++NVSILFADI GFT L+ QCTA+ELV+LLNELF +FD
Sbjct: 1 MKEDFLKPPERI-FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDE 59
Query: 360 LAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAI 404
LA E+HC RIK+LGDCYYCVSGL + + DHA CCVEMGLDMID I
Sbjct: 60 LATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTI 104
>U65473-1|AAD00121.1| 105|Homo sapiens adenylyl cyclase type V
protein.
Length = 105
Score = 149 bits (362), Expect = 2e-35
Identities = 68/94 (72%), Positives = 79/94 (84%)
Query: 416 NMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYK 475
NMRVGIH+GRVHC VLGLRKWQFDVWSNDVTLAN+ME+GG AGR+HITK TL L DY+
Sbjct: 1 NMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYE 60
Query: 476 VEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
VEPG GG RNAYLK+H+IET+LI+ R ++K
Sbjct: 61 VEPGCGGERNAYLKEHSIETFLILRCTQKRKEEK 94
>AK126468-1|BAC86560.1| 419|Homo sapiens protein ( Homo sapiens
cDNA FLJ44504 fis, clone UTERU3001240, highly similar
to Adenylate cyclase, type IV (EC 4.6.1.1). ).
Length = 419
Score = 114 bits (274), Expect = 9e-25
Identities = 52/103 (50%), Positives = 70/103 (67%)
Query: 407 VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
+R V++NMRVG+H+G V C V+GL+KWQ+DVWS+DVTLAN+ME+GGV GRVHIT T
Sbjct: 48 LRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGAT 107
Query: 467 LCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKK 509
L L Y VE +R+ YL++ TYL++ D+K
Sbjct: 108 LALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEK 150
>Y15723-1|CAA75738.1| 690|Homo sapiens soluble guanylyl cyclase
protein.
Length = 690
Score = 104 bits (249), Expect = 1e-21
Identities = 50/157 (31%), Positives = 90/157 (57%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL + D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
>U58855-1|AAB94794.1| 690|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 690
Score = 104 bits (249), Expect = 1e-21
Identities = 50/157 (31%), Positives = 90/157 (57%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL + D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 532 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
>AF233750-1|AAF64043.1| 564|Homo sapiens soluble guanylate cyclase
large subunit protein.
Length = 564
Score = 104 bits (249), Expect = 1e-21
Identities = 50/157 (31%), Positives = 90/157 (57%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 346 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 405
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
Y GL + D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 406 YCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 465
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 466 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 502
>BC028384-1|AAH28384.1| 690|Homo sapiens GUCY1A3 protein protein.
Length = 690
Score = 103 bits (247), Expect = 2e-21
Identities = 52/160 (32%), Positives = 96/160 (60%), Gaps = 6/160 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +GD
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVN---VNMRVGIHTGRVHCVVLG 432
Y GL + D HA V++ L + + L EVM+ + + MR+G+H+G V V+G
Sbjct: 532 YCVAGGLHKESDTHA---VQIALMAVKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVG 588
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
>X63282-1|CAA44921.1| 732|Homo sapiens alpha2-subunit of soluble
guanylyl cyclase protein.
Length = 732
Score = 101 bits (241), Expect = 9e-21
Identities = 51/155 (32%), Positives = 90/155 (58%)
Query: 312 QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 371
Q ++ +++++V++LF+DI GFT++ QCT +++ +LNEL+ RFD +++
Sbjct: 508 QGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVET 567
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVL 431
+GD Y +GL HAK M L M++ V + MR+GIH+G V V+
Sbjct: 568 IGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G+R ++ ++ N+VTLA+ ESG R++++ T
Sbjct: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662
>BC130488-1|AAI30489.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 101 bits (241), Expect = 9e-21
Identities = 51/155 (32%), Positives = 90/155 (58%)
Query: 312 QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 371
Q ++ +++++V++LF+DI GFT++ QCT +++ +LNEL+ RFD +++
Sbjct: 508 QGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVET 567
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVL 431
+GD Y +GL HAK M L M++ V + MR+GIH+G V V+
Sbjct: 568 IGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G+R ++ ++ N+VTLA+ ESG R++++ T
Sbjct: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662
>BC130484-1|AAI30485.1| 732|Homo sapiens guanylate cyclase 1,
soluble, alpha 2 protein.
Length = 732
Score = 101 bits (241), Expect = 9e-21
Identities = 51/155 (32%), Positives = 90/155 (58%)
Query: 312 QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 371
Q ++ +++++V++LF+DI GFT++ QCT +++ +LNEL+ RFD +++
Sbjct: 508 QGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVET 567
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVL 431
+GD Y +GL HAK M L M++ V + MR+GIH+G V V+
Sbjct: 568 IGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
G+R ++ ++ N+VTLA+ ESG R++++ T
Sbjct: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662
>X15357-1|CAA33417.1| 1061|Homo sapiens ANP-A receptor preprotein (AA
-32 to 1029) protein.
Length = 1061
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>S72628-1|AAD14112.1| 415|Homo sapiens atrial natriuretic peptide
receptor guanylate protein.
Length = 415
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 234 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 293
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 294 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 352
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 353 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 391
>BC063304-1|AAH63304.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>AL713889-5|CAI13614.1| 255|Homo sapiens natriuretic peptide
receptor A/guanylate cyclase A (atrionatriuretic peptide
re protein.
Length = 255
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 48 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 107
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 108 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 166
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 167 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 205
>AL713889-4|CAI13613.1| 1061|Homo sapiens natriuretic peptide receptor
A/guanylate cyclase A (atrionatriuretic peptide re
protein.
Length = 1061
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>AF190631-1|AAF01340.1| 1061|Homo sapiens natriuretic peptide receptor
A protein.
Length = 1061
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>AB010491-1|BAA31199.1| 1061|Homo sapiens natriuretic peptide A type
receptor protein.
Length = 1061
Score = 99.5 bits (237), Expect = 3e-20
Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 867 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDA 926
Query: 376 YYCVSGLPEARDDHAKCC--VEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVL 431
Y VSGLP R+ C M L ++DA+ +R + +R+GIHTG V V+
Sbjct: 927 YMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVV 985
Query: 432 GLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
GL+ ++ ++ + V A+ MES G A ++H++ ET L
Sbjct: 986 GLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1024
>M92432-1|AAA60547.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 99.1 bits (236), Expect = 4e-20
Identities = 55/163 (33%), Positives = 90/163 (55%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+E V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 876 FEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 935
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ A+ +R + V V +R+G+H+G V+GL +
Sbjct: 936 GLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 995
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET---LCCLGDDYKVE 477
+ ++ + V A+ MES G+ R+H+ T L L Y+VE
Sbjct: 996 YCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
>AJ222657-1|CAA10914.1| 1103|Homo sapiens guanylyl cyclase protein.
Length = 1103
Score = 99.1 bits (236), Expect = 4e-20
Identities = 55/163 (33%), Positives = 90/163 (55%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
+E V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 876 FEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 935
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ A+ +R + V V +R+G+H+G V+GL +
Sbjct: 936 GLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 995
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKET---LCCLGDDYKVE 477
+ ++ + V A+ MES G+ R+H+ T L L Y+VE
Sbjct: 996 YCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
>AF038499-1|AAD09440.2| 617|Homo sapiens soluble guanylyl cyclase
subunit beta 2 protein.
Length = 617
Score = 99.1 bits (236), Expect = 4e-20
Identities = 56/183 (30%), Positives = 100/183 (54%), Gaps = 10/183 (5%)
Query: 291 VLPRHVAMEMKAD----IASQPRH-----EQFHKIYIQRYENVSILFADICGFTSLSDQC 341
VL +H+A+E K A P+H + K+ +++ +ILF+D+ FT++ C
Sbjct: 348 VLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTAC 407
Query: 342 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM- 400
++V +LN ++++FDRL + H +++ +GD Y V G+P +HA+ L M
Sbjct: 408 EPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMR 467
Query: 401 IDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRV 460
I A + V + +RVGIHTG V V+G + ++ ++ + V A+ MES G+ +V
Sbjct: 468 ISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKV 527
Query: 461 HIT 463
H++
Sbjct: 528 HLS 530
>X66533-1|CAA47144.1| 619|Homo sapiens guanylate cyclase protein.
Length = 619
Score = 98.3 bits (234), Expect = 6e-20
Identities = 59/182 (32%), Positives = 101/182 (55%), Gaps = 10/182 (5%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEE----LVRLLNELFARFDR 359
+A++ RH++ + +RY+NV+ILF+ I GF + + + E +V LLN+L+ RFD
Sbjct: 402 VANELRHKR--PVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459
Query: 360 LAAEHH---CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVN 416
L +++ +GD Y VSGLPE HA+ + LDM++ V +V +V
Sbjct: 460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQ 518
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+ +GIHTG V V+G R ++ ++ N V L + E+ G G++++++ T CL
Sbjct: 519 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578
Query: 477 EP 478
+P
Sbjct: 579 DP 580
>BC047620-1|AAH47620.2| 619|Homo sapiens guanylate cyclase 1,
soluble, beta 3 protein.
Length = 619
Score = 98.3 bits (234), Expect = 6e-20
Identities = 59/182 (32%), Positives = 101/182 (55%), Gaps = 10/182 (5%)
Query: 304 IASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEE----LVRLLNELFARFDR 359
+A++ RH++ + +RY+NV+ILF+ I GF + + + E +V LLN+L+ RFD
Sbjct: 402 VANELRHKR--PVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459
Query: 360 LAAEHH---CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVN 416
L +++ +GD Y VSGLPE HA+ + LDM++ V +V +V
Sbjct: 460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQ 518
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKV 476
+ +GIHTG V V+G R ++ ++ N V L + E+ G G++++++ T CL
Sbjct: 519 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578
Query: 477 EP 478
+P
Sbjct: 579 DP 580
>BC023017-1|AAH23017.1| 618|Homo sapiens NPR2 protein protein.
Length = 618
Score = 98.3 bits (234), Expect = 6e-20
Identities = 51/154 (33%), Positives = 90/154 (58%), Gaps = 3/154 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 423 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDA 482
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSGLP HA M L ++DA++ +R + +R+G+HTG V V+G
Sbjct: 483 YMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVG 542
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
L+ ++ ++ + V A+ MES G A ++H++ T
Sbjct: 543 LKMPRYCLFGDTVNTASRMESNGQALKIHVSSTT 576
>AL133410-13|CAI10987.1| 1047|Homo sapiens natriuretic peptide
receptor B/guanylate cyclase B (atrionatriuretic peptide
re protein.
Length = 1047
Score = 98.3 bits (234), Expect = 6e-20
Identities = 51/154 (33%), Positives = 90/154 (58%), Gaps = 3/154 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 852 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDA 911
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSGLP HA M L ++DA++ +R + +R+G+HTG V V+G
Sbjct: 912 YMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVG 971
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
L+ ++ ++ + V A+ MES G A ++H++ T
Sbjct: 972 LKMPRYCLFGDTVNTASRMESNGQALKIHVSSTT 1005
>AB005647-1|BAA81737.1| 1047|Homo sapiens atrial natriuretic peptide
Btype receptor protein.
Length = 1047
Score = 98.3 bits (234), Expect = 6e-20
Identities = 51/154 (33%), Positives = 90/154 (58%), Gaps = 3/154 (1%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 852 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDA 911
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGRVHCVVLG 432
Y VSGLP HA M L ++DA++ +R + +R+G+HTG V V+G
Sbjct: 912 YMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVG 971
Query: 433 LRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
L+ ++ ++ + V A+ MES G A ++H++ T
Sbjct: 972 LKMPRYCLFGDTVNTASRMESNGQALKIHVSSTT 1005
>L37378-1|AAA74451.1| 1108|Homo sapiens guanylyl cyclase protein.
Length = 1108
Score = 97.9 bits (233), Expect = 8e-20
Identities = 53/163 (32%), Positives = 93/163 (57%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 880 FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 939
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ ++ +R + V V +R+G+H+G V V+GL +
Sbjct: 940 GLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPR 999
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCC---LGDDYKVE 477
+ ++ + V A+ MES G+ R+H++ T+ L + Y+VE
Sbjct: 1000 YCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
>AL031387-4|CAB41303.1| 1108|Homo sapiens guanylate cyclase 2F,
retinal protein.
Length = 1108
Score = 97.9 bits (233), Expect = 8e-20
Identities = 53/163 (32%), Positives = 93/163 (57%), Gaps = 6/163 (3%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
++ V++ F+DI GFT++S E+V LLN+L+ FD + H +++ +GD Y S
Sbjct: 880 FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVAS 939
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ HA M LD++ ++ +R + V V +R+G+H+G V V+GL +
Sbjct: 940 GLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPR 999
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCC---LGDDYKVE 477
+ ++ + V A+ MES G+ R+H++ T+ L + Y+VE
Sbjct: 1000 YCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
>M83533-1|AAA35523.2| 675|Homo sapiens adenylyl cyclase type V
protein.
Length = 675
Score = 95.9 bits (228), Expect = 3e-19
Identities = 65/196 (33%), Positives = 97/196 (49%), Gaps = 19/196 (9%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + R + ++Y Q Y+ V ++FA I GF Q E
Sbjct: 377 NILPSHVARHF----LEKDRDNE--ELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVE 430
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-PEARD-----DHAKCCVEM 396
+RLLNE+ A FD L E +IK +G Y VSGL PE + H +
Sbjct: 431 CLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADF 490
Query: 397 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGV 456
L + ++I + + N +R+GI G V V+G +K Q+D+W V LA+ M+S GV
Sbjct: 491 SLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGV 550
Query: 457 AGRVHITKETLCCLGD 472
+GR+ + +ET L D
Sbjct: 551 SGRIQVPEETYLILKD 566
>X66534-1|CAA47145.1| 717|Homo sapiens guanylate cyclase protein.
Length = 717
Score = 94.3 bits (224), Expect = 1e-18
Identities = 47/157 (29%), Positives = 88/157 (56%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ +++ NV++LF+DI GFT++ QC+ +++ +LN L+ RFD+ E +++ +
Sbjct: 469 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIAMP 528
Query: 376 YYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRK 435
+ GL + D HA M L M++ V + MR+G+H+G V V+G++
Sbjct: 529 IVWLGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 588
Query: 436 WQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGD 472
++ ++ N+VTLAN ES V +++++ T L D
Sbjct: 589 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 625
>AK056745-1|BAB71270.1| 506|Homo sapiens protein ( Homo sapiens
cDNA FLJ32183 fis, clone PLACE6001886, highly similar to
ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). ).
Length = 506
Score = 92.7 bits (220), Expect = 3e-18
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 24/199 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA + I R+E +Y Q YE V +LFA + F + E
Sbjct: 273 NVLPAHVAPQF---IGQNRRNED---LYHQSYECVCVLFASVPDFKEFYSESNINHEGLE 326
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----PEARDDHAKCCVEMG 397
+RLLNE+ A FD L ++ +IK +G Y +GL +A+ D + C +G
Sbjct: 327 CLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLG 386
Query: 398 LDMIDAIALVREVMAVNVN------MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
+ A+AL ++ +N + +RVG++ G V V+G +K Q+D+W N V +A+ M
Sbjct: 387 TMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRM 446
Query: 452 ESGGVAGRVHITKETLCCL 470
ES GV G++ +T+ET L
Sbjct: 447 ESTGVLGKIQVTEETAWAL 465
>S57551-1|AAB19934.2| 1073|Homo sapiens guanylate cyclase-coupled
enterotoxin receptor protein.
Length = 1073
Score = 92.3 bits (219), Expect = 4e-18
Identities = 45/153 (29%), Positives = 88/153 (57%), Gaps = 3/153 (1%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
YE V+I F+DI GFT++ T E+V +LN+++ FD + H +++ +GD Y S
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ + HA +M L+++ + + + + + +R+G+H+G V+G++ +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
+ ++ + V A+ MES G+ R+H++ T+ L
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
>M73489-1|AAA36655.1| 1073|Homo sapiens heat-stable enterotoxin
receptor protein.
Length = 1073
Score = 92.3 bits (219), Expect = 4e-18
Identities = 45/153 (29%), Positives = 88/153 (57%), Gaps = 3/153 (1%)
Query: 321 YENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 380
YE V+I F+DI GFT++ T E+V +LN+++ FD + H +++ +GD Y S
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
Query: 381 GLPEARDD-HAKCCVEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCVVLGLRKWQ 437
GLP+ + HA +M L+++ + + + + + +R+G+H+G V+G++ +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
Query: 438 FDVWSNDVTLANYMESGGVAGRVHITKETLCCL 470
+ ++ + V A+ MES G+ R+H++ T+ L
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
>U65474-1|AAD00122.1| 74|Homo sapiens adenylyl cyclase type VI
protein.
Length = 74
Score = 81.0 bits (191), Expect = 1e-14
Identities = 37/63 (58%), Positives = 48/63 (76%)
Query: 447 LANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRV 506
LAN+ME+GG AGR+HIT+ TL L DY+VEPG GG RNAYLK+ +IET+LI+ R
Sbjct: 1 LANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRK 60
Query: 507 DKK 509
++K
Sbjct: 61 EEK 63
>AF020340-1|AAB94877.1| 586|Homo sapiens soluble guanylate cyclase
beta-1 subunit protein.
Length = 586
Score = 80.6 bits (190), Expect = 1e-14
Identities = 46/139 (33%), Positives = 76/139 (54%), Gaps = 4/139 (2%)
Query: 343 AEELVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLD 399
A ++V LLN+L+ RFD L +++ +GD Y VSGLPE HA+ + LD
Sbjct: 410 AMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALD 469
Query: 400 MIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGR 459
M++ V +V +V + +GIHTG V V+G R ++ ++ N V L + E+ G G+
Sbjct: 470 MMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGK 528
Query: 460 VHITKETLCCLGDDYKVEP 478
+++++ T CL +P
Sbjct: 529 INVSEYTYRCLMSPENSDP 547
>X74210-1|CAA52282.1| 476|Homo sapiens adenylate cyclase protein.
Length = 476
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 243 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 296
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 297 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 356
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 357 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 416
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 417 DSTGVLDKIQVTEET 431
>L21993-1|AAA64923.1| 476|Homo sapiens adenylyl cyclase protein.
Length = 476
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 243 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 296
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 297 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 356
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 357 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 416
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 417 DSTGVLDKIQVTEET 431
>AF070583-1|AAC28647.1| 367|Homo sapiens adenylyl cyclase protein.
Length = 367
Score = 80.2 bits (189), Expect = 2e-14
Identities = 59/195 (30%), Positives = 96/195 (49%), Gaps = 24/195 (12%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
+VLP HVA +A ++E+ +Y Q Y+ V ++FA I F + E
Sbjct: 134 NVLPAHVAEHF---LARSLKNEE---LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 187
Query: 346 LVRLLNELFARFDRLAAEHHCL---RIKLLGDCYYCVSGL-----------PEARDDHAK 391
+RLLNE+ A FD L ++ +IK +G Y +GL PE + H
Sbjct: 188 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIG 247
Query: 392 CCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYM 451
VE ++ + + + + +RVGI+ G V V+G +K Q+D+W N V +A+ M
Sbjct: 248 TMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRM 307
Query: 452 ESGGVAGRVHITKET 466
+S GV ++ +T+ET
Sbjct: 308 DSTGVLDKIQVTEET 322
>AJ005282-1|CAA06466.1| 995|Homo sapiens NPR-Bi protein.
Length = 995
Score = 76.6 bits (180), Expect = 2e-13
Identities = 38/113 (33%), Positives = 66/113 (58%), Gaps = 3/113 (2%)
Query: 316 IYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDC 375
+ + +++V+I F+DI GFT+LS + T ++V LLN+L+ FD + +++ +GD
Sbjct: 852 VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDA 911
Query: 376 YYCVSGLPEARDD-HAKCCVEMGLDMIDAIA--LVREVMAVNVNMRVGIHTGR 425
Y VSGLP HA M L ++DA++ +R + +R+G+HTG+
Sbjct: 912 YMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGK 964
>AF497515-1|AAM94372.1| 301|Homo sapiens adenylate cyclase type I
protein.
Length = 301
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 13/199 (6%)
Query: 137 ALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRS------LTVSTGA 190
AL+ + L P + ++ L + + + A L F+ G + + T G
Sbjct: 104 ALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGV 163
Query: 191 CSLF--TYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIAT----LIA 244
L T+V+YA LPVR A GL +AA ++ L + +L+ T+ +
Sbjct: 164 WQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVG 223
Query: 245 CNAAGMLTHQPRELAQRRAFLETRDCVEAXXXXXXXXXXXXXXXXSVLPRHVAMEMKADI 304
N G+ E +QR+AFL+ R C+E S+LPR+VAMEMK D
Sbjct: 224 VNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF 283
Query: 305 ASQPRHEQFHKIYIQRYEN 323
+P FHKIYIQR++N
Sbjct: 284 L-KPPERIFHKIYIQRHDN 301
>AK075424-1|BAC11613.1| 378|Homo sapiens protein ( Homo sapiens
cDNA PSEC0115 fis, clone PLACE1000086, highly similar to
ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1). ).
Length = 378
Score = 72.9 bits (171), Expect = 3e-12
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 31/202 (15%)
Query: 290 SVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAE----E 345
++LP HVA + S+ R E+ +Y Q Y+ + ++FA + F + + E
Sbjct: 128 NMLPEHVARHF---LGSKKRDEE---LYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 181
Query: 346 LVRLLNELFARFDRLAAEHH---CLRIKLLGDCYYCVSGL-PEA---------------- 385
+R LNE+ + FD L +IK +G Y SG+ P+
Sbjct: 182 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 241
Query: 386 -RDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSND 444
R H + L M D + + N +R+G++ G V V+G RK +D+W N
Sbjct: 242 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNT 301
Query: 445 VTLANYMESGGVAGRVHITKET 466
V +A+ MES GV G + + +ET
Sbjct: 302 VNVASRMESTGVMGNIQVVEET 323
>AL160157-1|CAI15432.2| 385|Homo sapiens guanylate cyclase 1,
soluble, beta 2 protein.
Length = 385
Score = 67.3 bits (157), Expect = 1e-10
Identities = 35/119 (29%), Positives = 64/119 (53%), Gaps = 9/119 (7%)
Query: 291 VLPRHVAMEMKAD----IASQPRH-----EQFHKIYIQRYENVSILFADICGFTSLSDQC 341
VL +H+A+E K A P+H + K+ +++ +ILF+D+ FT++ C
Sbjct: 246 VLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTAC 305
Query: 342 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDM 400
++V +LN ++++FDRL + H +++ +GD Y V G+P +HA+ L M
Sbjct: 306 EPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGM 364
>Z50053-1|CAA90393.1| 763|Homo sapiens alpha2i-subunit of soluble
guanylyl cyclase protein.
Length = 763
Score = 66.9 bits (156), Expect = 2e-10
Identities = 30/91 (32%), Positives = 54/91 (59%)
Query: 312 QFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 371
Q ++ +++++V++LF+DI GFT++ QCT +++ +LNEL+ RFD +++
Sbjct: 508 QGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVET 567
Query: 372 LGDCYYCVSGLPEARDDHAKCCVEMGLDMID 402
+GD Y +GL HAK M L M++
Sbjct: 568 IGDAYCVAAGLHRKSLCHAKPIALMALKMME 598
Score = 43.6 bits (98), Expect = 0.002
Identities = 20/50 (40%), Positives = 34/50 (68%)
Query: 417 MRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKET 466
MR+GIH+G V V+G+R ++ ++ N+VTLA+ ESG R++++ T
Sbjct: 644 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 693
>BC015982-1|AAH15982.2| 130|Homo sapiens ADCY4 protein protein.
Length = 130
Score = 58.4 bits (135), Expect = 6e-08
Identities = 28/82 (34%), Positives = 47/82 (57%)
Query: 389 HAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLA 448
H VE + + + ++ + N +RVG++ G V V+G +K Q+D+W N V +A
Sbjct: 8 HLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVA 67
Query: 449 NYMESGGVAGRVHITKETLCCL 470
+ MES GV G++ +T+ET L
Sbjct: 68 SRMESTGVLGKIQVTEETAWAL 89
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.325 0.137 0.418
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 75,097,260
Number of Sequences: 224733
Number of extensions: 2895487
Number of successful extensions: 9258
Number of sequences better than 10.0: 70
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 9018
Number of HSP's gapped (non-prelim): 113
length of query: 566
length of database: 73,234,838
effective HSP length: 94
effective length of query: 472
effective length of database: 52,109,936
effective search space: 24595889792
effective search space used: 24595889792
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 68 (31.5 bits)
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