Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002043-TA|BGIBMGA002043-PA|IPR003018|GAF,
IPR002073|3'5'-cyclic nucleotide phosphodiesterase,
IPR003607|Metal-dependent phosphohydrolase, HD region
(929 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic... 697 0.0
UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase... 502 e-140
UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cycl... 483 e-134
UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella ve... 460 e-128
UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein;... 409 e-112
UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod... 373 e-101
UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP phosphod... 367 e-99
UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic phosphodies... 346 2e-93
UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP... 345 3e-93
UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and c... 344 6e-93
UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep: CG82... 336 2e-90
UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1; Strongy... 335 3e-90
UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep: E... 329 2e-88
UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to phosphodie... 322 4e-86
UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic phosphodiest... 319 2e-85
UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whol... 303 1e-80
UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep:... 302 2e-80
UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic phosphodieste... 282 3e-74
UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n... 269 2e-70
UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP p... 260 1e-67
UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome sh... 252 2e-65
UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic phosphod... 241 8e-62
UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21; ... 238 6e-61
UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to Phosphodie... 226 2e-57
UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 223 1e-56
UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 222 4e-56
UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase... 217 1e-54
UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 213 2e-53
UniRef50_Q4RNP2 Cluster: Chromosome 2 SCAF15010, whole genome sh... 204 1e-50
UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 203 2e-50
UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 202 3e-50
UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome sh... 180 2e-43
UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 178 6e-43
UniRef50_A2E5S0 Cluster: GAF domain containing protein; n=1; Tri... 177 1e-42
UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 166 3e-39
UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella ve... 164 9e-39
UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 163 1e-38
UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to cGMP-depen... 162 3e-38
UniRef50_A7SYX3 Cluster: Predicted protein; n=1; Nematostella ve... 161 1e-37
UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1; Tri... 161 1e-37
UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 158 6e-37
UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 157 2e-36
UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA... 156 2e-36
UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 155 7e-36
UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 153 3e-35
UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cycli... 152 4e-35
UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep:... 151 8e-35
UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 151 1e-34
UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 149 3e-34
UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic ... 148 8e-34
UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3; Tri... 148 8e-34
UniRef50_UPI00015B464B Cluster: PREDICTED: similar to ENSANGP000... 144 1e-32
UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 142 4e-32
UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648... 142 5e-32
UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 142 5e-32
UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 141 7e-32
UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3; D... 137 1e-30
UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1; Tri... 136 2e-30
UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 131 1e-28
UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus lu... 127 1e-27
UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, wh... 127 1e-27
UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 126 3e-27
UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 126 3e-27
UniRef50_UPI0000E47CF4 Cluster: PREDICTED: similar to camp/cgmp ... 124 8e-27
UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic ... 123 3e-26
UniRef50_A2EAR4 Cluster: GAF domain containing protein; n=1; Tri... 123 3e-26
UniRef50_Q090R6 Cluster: CGMP-dependent 3',5'-cyclic phosphodies... 120 1e-25
UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-speci... 120 2e-25
UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 120 2e-25
UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, wh... 118 6e-25
UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep: MG... 118 7e-25
UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3; ... 118 7e-25
UniRef50_A2DVK5 Cluster: GAF domain containing protein; n=1; Tri... 117 1e-24
UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic phosphodiest... 117 1e-24
UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 117 2e-24
UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase... 116 3e-24
UniRef50_A2FCG3 Cluster: GAF domain containing protein; n=1; Tri... 115 5e-24
UniRef50_A5V6C5 Cluster: Putative adenylate/guanylate cyclase; n... 115 7e-24
UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3; L... 115 7e-24
UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1; Strongylocent... 115 7e-24
UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cycli... 114 9e-24
UniRef50_Q7A2D9 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 113 2e-23
UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide pho... 113 2e-23
UniRef50_A3WDP1 Cluster: Adenylate/Guanylate Cyclase; n=1; Eryth... 113 2e-23
UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiestera... 113 2e-23
UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep:... 113 2e-23
UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 113 2e-23
UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 113 3e-23
UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=... 112 4e-23
UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic phosphodiest... 112 5e-23
UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to phosphodie... 111 6e-23
UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to Phosphodie... 111 8e-23
UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide pho... 111 8e-23
UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella ve... 111 8e-23
UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1; ... 110 1e-22
UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide pho... 110 2e-22
UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=3... 110 2e-22
UniRef50_Q1IM31 Cluster: Serine phosphatase; n=1; Acidobacteria ... 109 4e-22
UniRef50_A0LL31 Cluster: Serine phosphatase; n=1; Syntrophobacte... 108 6e-22
UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase... 108 8e-22
UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3; Trypa... 107 1e-21
UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to phosphodie... 106 2e-21
UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p ... 106 3e-21
UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cycl... 106 3e-21
UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep:... 105 4e-21
UniRef50_Q24GJ8 Cluster: GAF domain containing protein; n=1; Tet... 105 6e-21
UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep:... 104 1e-20
UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, wh... 104 1e-20
UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 104 1e-20
UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic phosphodiester... 104 1e-20
UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 104 1e-20
UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, wh... 103 2e-20
UniRef50_A0LGQ1 Cluster: Putative PAS/PAC sensor protein; n=1; S... 103 3e-20
UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 103 3e-20
UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome sh... 102 5e-20
UniRef50_Q23PX5 Cluster: GAF domain containing protein; n=1; Tet... 102 5e-20
UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to ENSANGP000... 101 7e-20
UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide pho... 101 1e-19
UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, wh... 101 1e-19
UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 100 2e-19
UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163, w... 100 2e-19
UniRef50_Q1IKE0 Cluster: Diguanylate cyclase with GAF sensor; n=... 99 3e-19
UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whol... 100 4e-19
UniRef50_Q7M8J3 Cluster: RESPONSE REGULATOR PROTEIN-CheY-like nd... 100 4e-19
UniRef50_A0YPV9 Cluster: Adenylate/Guanylate Cyclase; n=1; Lyngb... 100 4e-19
UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 100 4e-19
UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, wh... 100 4e-19
UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 99 5e-19
UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, wh... 99 5e-19
UniRef50_Q8YVS0 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 99 6e-19
UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2; Cryptos... 98 8e-19
UniRef50_A0NF29 Cluster: ENSANGP00000029810; n=2; Endopterygota|... 98 8e-19
UniRef50_A0WBQ4 Cluster: Diguanylate cyclase with GAF sensor; n=... 98 1e-18
UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p - ... 98 1e-18
UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, w... 98 1e-18
UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP phosp... 97 2e-18
UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3; P... 97 2e-18
UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella ve... 97 2e-18
UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 97 3e-18
UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome s... 96 3e-18
UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr... 96 3e-18
UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide pho... 96 4e-18
UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies... 96 4e-18
UniRef50_Q23RX8 Cluster: GAF domain containing protein; n=1; Tet... 95 6e-18
UniRef50_O95263 Cluster: High affinity cAMP-specific and IBMX-in... 95 6e-18
UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13; Euteleostom... 95 1e-17
UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affin... 94 1e-17
UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic phosphodies... 94 1e-17
UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, wh... 93 3e-17
UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome s... 93 4e-17
UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome s... 93 4e-17
UniRef50_Q53E02 Cluster: TaR2; n=5; Cystobacterineae|Rep: TaR2 -... 93 4e-17
UniRef50_A4J938 Cluster: Metal dependent phosphohydrolase; n=1; ... 92 5e-17
UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 92 7e-17
UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep: PD... 92 7e-17
UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase... 92 7e-17
UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whol... 91 1e-16
UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 91 1e-16
UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, wh... 91 1e-16
UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome sh... 90 3e-16
UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1; Ostr... 89 4e-16
UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 89 5e-16
UniRef50_Q22SL3 Cluster: GAF domain containing protein; n=1; Tet... 89 7e-16
UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, wh... 89 7e-16
UniRef50_A0C536 Cluster: Chromosome undetermined scaffold_15, wh... 89 7e-16
UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139, w... 89 7e-16
UniRef50_Q8F1G6 Cluster: Sigma factor sigB regulation protein rs... 88 9e-16
UniRef50_A0H2E0 Cluster: GAF; n=2; Chloroflexus|Rep: GAF - Chlor... 88 9e-16
UniRef50_A5UVY8 Cluster: GAF sensor signal transduction histidin... 88 1e-15
UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus lu... 88 1e-15
UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to phosphodie... 87 2e-15
UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome s... 87 2e-15
UniRef50_A5UQK5 Cluster: Sensor protein; n=2; Roseiflexus|Rep: S... 87 2e-15
UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 87 2e-15
UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase, pu... 87 2e-15
UniRef50_Q53I59 Cluster: Cyclic nucleotide specific phosphodiest... 87 3e-15
UniRef50_Q01S08 Cluster: Transcriptional regulator, NifA subfami... 85 8e-15
UniRef50_A0C3Y8 Cluster: Chromosome undetermined scaffold_148, w... 85 8e-15
UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, wh... 85 1e-14
UniRef50_Q73KY8 Cluster: Sigma-54 dependent transcriptional regu... 84 1e-14
UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase... 84 1e-14
UniRef50_Q8CXS5 Cluster: CGMP-dependent 3',5'-cyclic phosphodies... 82 6e-14
UniRef50_Q83A76 Cluster: GAF domain protein; n=5; Coxiella burne... 82 6e-14
UniRef50_Q04NN0 Cluster: Serine phosphatase RsbU, regulator of s... 82 6e-14
UniRef50_A2E4B2 Cluster: Response regulator receiver domain cont... 82 6e-14
UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide phosphodiester... 82 8e-14
UniRef50_A6C1F0 Cluster: Probable two-component response regulat... 81 1e-13
UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus muscul... 81 1e-13
UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2; Eukar... 81 2e-13
UniRef50_Q53S13 Cluster: Putative uncharacterized protein PDE11A... 81 2e-13
UniRef50_UPI00006CA67B Cluster: GAF domain containing protein; n... 80 3e-13
UniRef50_A5UTQ7 Cluster: Sensor protein; n=1; Roseiflexus sp. RS... 80 3e-13
UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase, p... 79 4e-13
UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1; ... 79 5e-13
UniRef50_Q8F3G8 Cluster: Sigma factor sigB regulation protein rs... 78 1e-12
UniRef50_Q73JB6 Cluster: GAF domain/HD domain protein; n=1; Trep... 77 2e-12
UniRef50_A7AVW3 Cluster: cAMP-specific phosphodiesterase, putati... 77 2e-12
UniRef50_Q0LHC9 Cluster: Metal-dependent phosphohydrolase, HD su... 77 2e-12
UniRef50_A2EE12 Cluster: GAF domain containing protein; n=1; Tri... 77 2e-12
UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic nuc... 77 3e-12
UniRef50_A6GDL8 Cluster: Sigma-54 dependent transcriptional regu... 77 3e-12
UniRef50_Q1IL10 Cluster: Serine phosphatase; n=1; Acidobacteria ... 76 5e-12
UniRef50_Q0LNF0 Cluster: Sensor protein; n=1; Herpetosiphon aura... 76 5e-12
UniRef50_A4LZ56 Cluster: Diguanylate cyclase with GAF sensor; n=... 76 5e-12
UniRef50_A5UV73 Cluster: Metal dependent phosphohydrolase; n=4; ... 75 7e-12
UniRef50_Q2LUL4 Cluster: General secretion pathway protein E; n=... 75 9e-12
UniRef50_Q31LP1 Cluster: GAF; n=2; Synechococcus elongatus|Rep: ... 75 1e-11
UniRef50_A4VD13 Cluster: Putative uncharacterized protein; n=1; ... 75 1e-11
UniRef50_A5UXN7 Cluster: Sensor protein; n=5; Chloroflexi (class... 74 2e-11
UniRef50_Q3JEL0 Cluster: Protein phosphatase 2C-like, stage II s... 73 3e-11
UniRef50_A0H3D2 Cluster: Sensor protein; n=4; Chloroflexaceae|Re... 73 3e-11
UniRef50_A2FCG2 Cluster: GAF domain containing protein; n=1; Tri... 73 3e-11
UniRef50_A2DCH1 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 73 4e-11
UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, wh... 73 4e-11
UniRef50_Q8DLK6 Cluster: Tlr0485 protein; n=3; Cyanobacteria|Rep... 72 6e-11
UniRef50_A3ZU96 Cluster: Probable two-component response regulat... 72 6e-11
UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces cap... 72 6e-11
UniRef50_Q4FPK0 Cluster: Sigma factor sigB regulation protein; n... 71 1e-10
UniRef50_Q31L46 Cluster: Metal dependent phosphohydrolase; n=2; ... 71 1e-10
UniRef50_A0W5M8 Cluster: Metal dependent phosphohydrolase; n=2; ... 71 2e-10
UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic phosp... 70 3e-10
UniRef50_Q2WAI7 Cluster: Serine phosphatase RsbU; n=3; Magnetosp... 70 3e-10
UniRef50_A0W4L6 Cluster: Metal dependent phosphohydrolase; n=2; ... 69 4e-10
UniRef50_Q8EZC6 Cluster: GGDEF domain protein; n=4; Leptospira|R... 69 8e-10
UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, wh... 69 8e-10
UniRef50_Q2JV17 Cluster: GAF domain protein; n=2; Synechococcus|... 68 1e-09
UniRef50_Q025X3 Cluster: Serine phosphatase; n=1; Solibacter usi... 68 1e-09
UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2; ... 68 1e-09
UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia... 68 1e-09
UniRef50_Q1D911 Cluster: GAF/GGDEF domain protein; n=3; Cystobac... 67 2e-09
UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic phos... 66 5e-09
UniRef50_Q6MLW2 Cluster: NtrC family transcriptional regulator; ... 65 7e-09
UniRef50_Q2LSR2 Cluster: HD-GYP domain protein; n=1; Syntrophus ... 65 7e-09
UniRef50_Q2IFQ3 Cluster: Putative GAF sensor protein; n=1; Anaer... 65 7e-09
UniRef50_Q0LJE8 Cluster: Sensor protein; n=1; Herpetosiphon aura... 65 7e-09
UniRef50_A1HLR9 Cluster: Diguanylate cyclase/phosphodiesterase w... 65 1e-08
UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans H... 65 1e-08
UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 64 2e-08
UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1; ... 64 2e-08
UniRef50_A1K343 Cluster: HD-domain containing protein; n=2; Prot... 64 2e-08
UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cycl... 64 2e-08
UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4; ... 64 2e-08
UniRef50_A0L8S2 Cluster: Metal dependent phosphohydrolase; n=6; ... 63 3e-08
UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, wh... 63 3e-08
UniRef50_A0W5Q9 Cluster: Putative GAF sensor protein; n=1; Geoba... 63 4e-08
UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2; Crypto... 63 4e-08
UniRef50_Q5BYM4 Cluster: SJCHGC06481 protein; n=1; Schistosoma j... 63 4e-08
UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1; Crypto... 63 4e-08
UniRef50_Q1II68 Cluster: Metal dependent phosphohydrolase; n=1; ... 62 5e-08
UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans N... 62 5e-08
UniRef50_A0LKA7 Cluster: Metal dependent phosphohydrolase; n=4; ... 62 7e-08
UniRef50_UPI0000660DD6 Cluster: Homolog of Homo sapiens "Phospho... 61 2e-07
UniRef50_A6LSE0 Cluster: Diguanylate cyclase; n=1; Clostridium b... 61 2e-07
UniRef50_A6GI21 Cluster: Sensor protein; n=1; Plesiocystis pacif... 61 2e-07
UniRef50_Q4FXD4 Cluster: Putative uncharacterized protein; n=3; ... 61 2e-07
UniRef50_Q29FT2 Cluster: GA17041-PA; n=1; Drosophila pseudoobscu... 61 2e-07
UniRef50_UPI00006A17C5 Cluster: cGMP-inhibited 3',5'-cyclic phos... 60 2e-07
UniRef50_A6GFS9 Cluster: Sensor protein; n=1; Plesiocystis pacif... 60 2e-07
UniRef50_A1WTT3 Cluster: Metal dependent phosphohydrolase; n=1; ... 60 2e-07
UniRef50_A0XZ13 Cluster: Metal dependent phosphohydrolase; n=1; ... 60 3e-07
UniRef50_Q74BT7 Cluster: Sensor protein; n=2; Geobacter|Rep: Sen... 60 4e-07
UniRef50_Q0LKQ1 Cluster: GGDEF domain; n=1; Herpetosiphon aurant... 60 4e-07
UniRef50_A2FSQ8 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 60 4e-07
UniRef50_Q1PXG2 Cluster: Putative uncharacterized protein; n=1; ... 59 5e-07
UniRef50_Q5C1P7 Cluster: SJCHGC07646 protein; n=1; Schistosoma j... 59 5e-07
UniRef50_Q0B026 Cluster: Metal dependent phosphohydrolase; n=2; ... 59 6e-07
UniRef50_Q74ER5 Cluster: GAF domain/GGDEF domain protein; n=2; G... 58 8e-07
UniRef50_UPI000023CCA1 Cluster: hypothetical protein FG06914.1; ... 58 1e-06
UniRef50_A6G506 Cluster: Metal dependent phosphohydrolase; n=1; ... 58 1e-06
UniRef50_Q30S23 Cluster: Metal dependent phosphohydrolase; n=2; ... 58 1e-06
UniRef50_A6FZ14 Cluster: Sensor protein; n=1; Plesiocystis pacif... 58 1e-06
UniRef50_Q08NK5 Cluster: Sensor protein; n=1; Stigmatella aurant... 57 2e-06
UniRef50_A6G581 Cluster: Sensor protein; n=1; Plesiocystis pacif... 57 2e-06
UniRef50_A1HTU0 Cluster: Diguanylate cyclase precursor; n=1; The... 57 3e-06
UniRef50_Q0V6F8 Cluster: Putative uncharacterized protein; n=1; ... 57 3e-06
UniRef50_UPI0001555C30 Cluster: PREDICTED: hypothetical protein,... 56 3e-06
UniRef50_Q82SM4 Cluster: Bacterial type II secretion system prot... 56 3e-06
UniRef50_Q1K0H7 Cluster: Sensor protein; n=1; Desulfuromonas ace... 56 4e-06
UniRef50_Q0LQW5 Cluster: Stage II sporulation E; n=1; Herpetosip... 56 4e-06
UniRef50_A4B1J5 Cluster: Phosphoenolpyruvate-protein phosphotran... 56 4e-06
UniRef50_A3TKM4 Cluster: GAF:ATP-binding region, ATPase-like; n=... 56 4e-06
UniRef50_Q1NJC2 Cluster: GAF precursor; n=2; delta proteobacteri... 56 6e-06
UniRef50_A4J477 Cluster: Diguanylate cyclase/phosphodiesterase w... 56 6e-06
UniRef50_A0Z996 Cluster: Sensor protein; n=1; marine gamma prote... 56 6e-06
UniRef50_A0H2P6 Cluster: Sensor protein; n=2; Chloroflexus|Rep: ... 56 6e-06
UniRef50_Q4SV96 Cluster: Chromosome 10 SCAF13771, whole genome s... 55 8e-06
UniRef50_Q2BPD4 Cluster: Bacterial type II secretion system prot... 55 8e-06
UniRef50_Q1IVB0 Cluster: Multi sensor diguanylate cyclase / meta... 55 8e-06
UniRef50_Q2SC53 Cluster: Phosphotransferase system enzyme I PtsP... 55 1e-05
UniRef50_Q1PXJ5 Cluster: Putative uncharacterized protein; n=1; ... 55 1e-05
UniRef50_A4G3J3 Cluster: Sensor protein; n=1; Herminiimonas arse... 54 1e-05
UniRef50_A5DVX9 Cluster: Putative uncharacterized protein; n=1; ... 54 1e-05
UniRef50_Q47TU6 Cluster: GAF domain protein; n=7; Actinomycetale... 54 2e-05
UniRef50_A5UX58 Cluster: Diguanylate cyclase; n=4; Roseiflexus|R... 54 2e-05
UniRef50_A4CGH4 Cluster: Sensor protein; n=1; Robiginitalea bifo... 54 2e-05
UniRef50_UPI0000E45FE8 Cluster: PREDICTED: similar to ankyrin 2,... 54 2e-05
UniRef50_Q39SE1 Cluster: Putative GAF sensor protein; n=1; Geoba... 54 2e-05
UniRef50_A6SWA6 Cluster: Sensor protein; n=1; Janthinobacterium ... 54 2e-05
UniRef50_A0GKX1 Cluster: Sensor protein; n=2; Proteobacteria|Rep... 54 2e-05
UniRef50_A2G4P7 Cluster: GAF domain containing protein; n=1; Tri... 54 2e-05
UniRef50_Q1N6Q6 Cluster: HD-GYP domain protein; n=1; Oceanobacte... 53 3e-05
UniRef50_A5UVM1 Cluster: Sensor protein; n=2; Roseiflexus|Rep: S... 53 4e-05
UniRef50_A0L7V4 Cluster: Metal dependent phosphohydrolase precur... 53 4e-05
UniRef50_A6QBE4 Cluster: Putative uncharacterized protein; n=1; ... 52 5e-05
UniRef50_A6G4K4 Cluster: Sensor protein; n=1; Plesiocystis pacif... 52 5e-05
UniRef50_A0JWU5 Cluster: Putative signal transduction histidine ... 52 5e-05
UniRef50_Q1Q7L2 Cluster: Similar to response regulatory protein;... 52 7e-05
UniRef50_Q0LMZ0 Cluster: Sensor protein; n=1; Herpetosiphon aura... 52 7e-05
UniRef50_Q0F0P8 Cluster: Sensory box/GGDEF family protein; n=1; ... 52 7e-05
UniRef50_Q8F687 Cluster: Serine/threonine protein kinases; n=5; ... 52 1e-04
UniRef50_Q2BPD6 Cluster: Metal dependent phosphohydrolase; n=1; ... 52 1e-04
UniRef50_Q0LIF4 Cluster: ATP-binding region, ATPase-like precurs... 52 1e-04
UniRef50_Q7UK84 Cluster: Probable two-component response regulat... 51 1e-04
UniRef50_Q93TY5 Cluster: Putative adenylate cyclase CyaA; n=1; T... 51 2e-04
UniRef50_Q3W4L5 Cluster: GAF:ATP-binding region, ATPase-like pre... 51 2e-04
UniRef50_A5V1N1 Cluster: Sensor protein; n=2; Roseiflexus|Rep: S... 51 2e-04
UniRef50_A2F4K8 Cluster: GAF domain containing protein; n=1; Tri... 51 2e-04
UniRef50_Q3KVL8 Cluster: High-affinity phosphodiesterase; n=4; E... 51 2e-04
UniRef50_Q0LK14 Cluster: Sensor protein; n=1; Herpetosiphon aura... 50 2e-04
UniRef50_A1GBW5 Cluster: Signal transduction histidine kinase, n... 50 2e-04
UniRef50_A0H095 Cluster: Sensor protein; n=2; Chloroflexus|Rep: ... 50 2e-04
UniRef50_Q5C402 Cluster: SJCHGC07495 protein; n=1; Schistosoma j... 50 2e-04
UniRef50_Q0LMK4 Cluster: Sensor protein; n=1; Herpetosiphon aura... 50 3e-04
UniRef50_O94034 Cluster: Nucleotide phosphodiesterase; n=4; Sacc... 50 3e-04
UniRef50_Q5L217 Cluster: Sensor protein; n=3; Bacillaceae|Rep: S... 50 4e-04
UniRef50_Q47KE3 Cluster: GAF:ATP-binding region, ATPase-like; n=... 50 4e-04
UniRef50_Q31JE4 Cluster: Metal dependent phosphohydrolase; n=1; ... 50 4e-04
UniRef50_Q1D5B9 Cluster: Sensor protein; n=1; Myxococcus xanthus... 50 4e-04
UniRef50_A0GY27 Cluster: Stage II sporulation E; n=2; Chloroflex... 50 4e-04
UniRef50_Q0LHI5 Cluster: Sensor protein; n=1; Herpetosiphon aura... 49 5e-04
UniRef50_A6G2A7 Cluster: Sensor protein; n=1; Plesiocystis pacif... 49 5e-04
UniRef50_A6CD98 Cluster: Sensor protein; n=1; Planctomyces maris... 49 5e-04
UniRef50_A4XM27 Cluster: Diguanylate cyclase; n=1; Caldicellulos... 49 5e-04
UniRef50_A4TX64 Cluster: Methyl-accepting chemotaxis protein; n=... 49 5e-04
UniRef50_Q74DK0 Cluster: Response regulator; n=3; Geobacter|Rep:... 49 7e-04
UniRef50_Q1PXD5 Cluster: Putative uncharacterized protein; n=1; ... 49 7e-04
UniRef50_Q0BUK2 Cluster: Phosphoenolpyruvate-protein phosphotran... 49 7e-04
UniRef50_A6FZT9 Cluster: Sensor protein; n=1; Plesiocystis pacif... 49 7e-04
UniRef50_A5UUW0 Cluster: Sensor protein; n=2; Roseiflexus|Rep: S... 49 7e-04
UniRef50_A2EA57 Cluster: 3'5'-cyclic nucleotide phosphodiesteras... 49 7e-04
UniRef50_Q8YZY1 Cluster: Sensor protein; n=2; Nostocaceae|Rep: S... 48 9e-04
UniRef50_Q1IN96 Cluster: Putative GAF sensor protein; n=1; Acido... 48 9e-04
UniRef50_Q1IM85 Cluster: Sensor protein; n=1; Acidobacteria bact... 48 9e-04
UniRef50_Q01WV2 Cluster: Adenylate/guanylate cyclase; n=1; Solib... 48 9e-04
UniRef50_Q7RXW7 Cluster: Putative uncharacterized protein NCU004... 48 9e-04
UniRef50_Q8F9P5 Cluster: Nif-specific regulatory protein; n=4; L... 48 0.001
UniRef50_A7HJ01 Cluster: Metal dependent phosphohydrolase; n=2; ... 48 0.001
UniRef50_A7BYE9 Cluster: Serine/threonine kinase with two-compon... 48 0.001
UniRef50_A6GDA4 Cluster: Sensor protein; n=1; Plesiocystis pacif... 48 0.001
UniRef50_Q47Y28 Cluster: Phosphoenolpyruvate-protein phosphotran... 48 0.002
UniRef50_A0EDW1 Cluster: Chromosome undetermined scaffold_90, wh... 48 0.002
UniRef50_Q8YV44 Cluster: Two-component sensor histidine kinase; ... 47 0.002
UniRef50_Q2IQ06 Cluster: Sensor protein; n=1; Anaeromyxobacter d... 47 0.002
UniRef50_Q3DYZ8 Cluster: GAF:ATP-binding region, ATPase-like:His... 47 0.002
UniRef50_Q0LGS9 Cluster: GGDEF domain; n=1; Herpetosiphon aurant... 47 0.002
UniRef50_Q609J6 Cluster: Polyketide synthase; n=1; Methylococcus... 47 0.003
UniRef50_Q2W7A5 Cluster: Predicted ATPase; n=1; Magnetospirillum... 47 0.003
UniRef50_Q2W335 Cluster: Predicted ATPase; n=1; Magnetospirillum... 47 0.003
UniRef50_Q1NPH4 Cluster: Sensor protein; n=1; delta proteobacter... 47 0.003
UniRef50_Q0LNE3 Cluster: Sensor protein; n=1; Herpetosiphon aura... 47 0.003
UniRef50_A2SP17 Cluster: Sugar diacid utilization regulator-like... 47 0.003
UniRef50_A0LS79 Cluster: Putative signal transduction histidine ... 47 0.003
UniRef50_A0LIA4 Cluster: Putative GAF sensor protein; n=1; Syntr... 47 0.003
UniRef50_Q89RB0 Cluster: Sensor protein; n=2; Rhizobiales|Rep: S... 46 0.004
UniRef50_Q89QL8 Cluster: Sensor protein; n=2; Rhizobiales|Rep: S... 46 0.004
UniRef50_Q72EL2 Cluster: GAF domain protein; n=2; Desulfovibrio ... 46 0.004
UniRef50_Q10YL5 Cluster: Sensor protein; n=3; Cyanobacteria|Rep:... 46 0.004
UniRef50_Q0YGJ6 Cluster: GGDEF domain; n=1; Geobacter sp. FRC-32... 46 0.004
UniRef50_A5D1X2 Cluster: Putative uncharacterized protein; n=1; ... 46 0.004
UniRef50_P06776 Cluster: 3',5'-cyclic-nucleotide phosphodiestera... 46 0.004
UniRef50_Q8YTN2 Cluster: Sensor protein; n=2; Nostocaceae|Rep: S... 46 0.005
UniRef50_Q1NII7 Cluster: GAF:Metal-dependent phosphohydrolase, H... 46 0.005
UniRef50_A6PCE1 Cluster: Metal dependent phosphohydrolase; n=1; ... 46 0.005
UniRef50_A6DQP3 Cluster: Putative GAF sensor protein; n=1; Lenti... 46 0.005
UniRef50_A1FD97 Cluster: Sensor protein; n=3; Pseudomonas putida... 46 0.005
UniRef50_Q465N5 Cluster: Putative uncharacterized protein; n=2; ... 46 0.005
UniRef50_Q8YUQ3 Cluster: Sensor protein; n=2; Bacteria|Rep: Sens... 46 0.006
UniRef50_Q3W3M1 Cluster: GAF:ATP-binding region, ATPase-like; n=... 46 0.006
UniRef50_Q0LQ58 Cluster: Sensor protein; n=1; Herpetosiphon aura... 46 0.006
UniRef50_A5UW73 Cluster: Protein serine phosphatase with GAF(S) ... 46 0.006
UniRef50_A0WCC8 Cluster: Response regulator receiver modulated G... 46 0.006
UniRef50_Q4C6M8 Cluster: PleD gene product; n=1; Crocosphaera wa... 45 0.008
UniRef50_A6EXE2 Cluster: Serine/threonine kinase with two-compon... 45 0.008
UniRef50_Q9XBM4 Cluster: Sensor protein; n=3; Cystobacterineae|R... 45 0.011
UniRef50_Q9RNG5 Cluster: Phosphoenolpyruvate-protein phosphotran... 45 0.011
UniRef50_Q3E3Y2 Cluster: Sensor protein; n=2; Chloroflexus|Rep: ... 45 0.011
UniRef50_UPI0000E0EEEB Cluster: general secretion pathway protei... 44 0.014
UniRef50_A6FY34 Cluster: Sensor protein; n=1; Plesiocystis pacif... 44 0.014
UniRef50_A5D5Z4 Cluster: Sensor protein; n=1; Pelotomaculum ther... 44 0.014
UniRef50_Q6CY30 Cluster: Similar to sp|P06776 Saccharomyces cere... 44 0.014
UniRef50_Q0W3A5 Cluster: Sensor protein; n=1; uncultured methano... 44 0.014
UniRef50_Q2RGK0 Cluster: Metal dependent phosphohydrolase; n=1; ... 44 0.019
UniRef50_Q3E1D6 Cluster: GGDEF; n=2; Chloroflexus|Rep: GGDEF - C... 44 0.019
UniRef50_Q0LH94 Cluster: Stage II sporulation E precursor; n=1; ... 44 0.019
UniRef50_Q09D69 Cluster: Sensor protein; n=1; Stigmatella aurant... 44 0.019
UniRef50_A6C6H7 Cluster: Putative uncharacterized protein; n=1; ... 44 0.019
UniRef50_A1ZPR5 Cluster: Serine/threonine kinase with GAF domain... 44 0.019
UniRef50_A1SFD0 Cluster: GAF domain protein; n=1; Nocardioides s... 44 0.019
UniRef50_Q5LP18 Cluster: Phosphoenolpyruvate-protein phosphotran... 44 0.025
UniRef50_Q3E582 Cluster: GAF; n=1; Chloroflexus aurantiacus J-10... 44 0.025
UniRef50_Q2BHT1 Cluster: Sensor protein; n=1; Neptuniibacter cae... 44 0.025
UniRef50_Q1IL92 Cluster: Sensor protein; n=2; Bacteria|Rep: Sens... 44 0.025
UniRef50_Q113I0 Cluster: Sensor protein; n=1; Trichodesmium eryt... 44 0.025
UniRef50_Q0SEH4 Cluster: Sensor kinase, two-component system; n=... 44 0.025
UniRef50_Q0A623 Cluster: Putative GAF sensor protein; n=1; Alkal... 44 0.025
UniRef50_Q092C7 Cluster: Sensor protein; n=1; Stigmatella aurant... 44 0.025
UniRef50_A6GB99 Cluster: Sensor protein; n=1; Plesiocystis pacif... 44 0.025
UniRef50_A6G485 Cluster: Sensor protein; n=1; Plesiocystis pacif... 44 0.025
UniRef50_A3PVG2 Cluster: GAF sensor signal transduction histidin... 44 0.025
UniRef50_A0YQ59 Cluster: Sensor protein; n=1; Lyngbya sp. PCC 81... 44 0.025
UniRef50_Q5C3V6 Cluster: SJCHGC08281 protein; n=1; Schistosoma j... 44 0.025
UniRef50_UPI00006CA9CC Cluster: GAF domain containing protein; n... 43 0.033
UniRef50_Q3M1D8 Cluster: Serine/Threonine protein kinase and Sig... 43 0.033
UniRef50_Q3E5U5 Cluster: PAS:Adenylyl cyclase class-3/4/guanylyl... 43 0.033
UniRef50_Q1NX85 Cluster: PAS; n=3; delta proteobacterium MLMS-1|... 43 0.033
UniRef50_Q097E6 Cluster: TaR2; n=1; Stigmatella aurantiaca DW4/3... 43 0.033
UniRef50_A5V255 Cluster: GAF sensor signal transduction histidin... 43 0.033
UniRef50_A1HRZ7 Cluster: Diguanylate cyclase; n=1; Thermosinus c... 43 0.033
UniRef50_Q758Y3 Cluster: ADR395Cp; n=1; Eremothecium gossypii|Re... 43 0.033
UniRef50_Q74C06 Cluster: GGDEF domain protein; n=4; Geobacter|Re... 43 0.044
UniRef50_Q1PWN3 Cluster: Sensor protein; n=1; Candidatus Kueneni... 43 0.044
UniRef50_Q1LCF8 Cluster: Sensor protein; n=1; Ralstonia metallid... 43 0.044
UniRef50_Q0LGE0 Cluster: Sensor protein; n=1; Herpetosiphon aura... 43 0.044
UniRef50_A6C5B5 Cluster: Putative uncharacterized protein; n=1; ... 43 0.044
UniRef50_A0CYW4 Cluster: Chromosome undetermined scaffold_31, wh... 43 0.044
UniRef50_Q8STT1 Cluster: Putative uncharacterized protein ECU09_... 43 0.044
UniRef50_A7TPP3 Cluster: Putative uncharacterized protein; n=1; ... 43 0.044
UniRef50_A4RPY9 Cluster: Putative uncharacterized protein; n=1; ... 43 0.044
UniRef50_UPI00006CD10E Cluster: 3''''5''''-cyclic nucleotide pho... 42 0.058
UniRef50_Q83BF9 Cluster: Phosphoenolpyruvate-protein phosphotran... 42 0.058
UniRef50_Q7UP36 Cluster: Putative uncharacterized protein; n=1; ... 42 0.058
UniRef50_Q2JCY0 Cluster: Putative signal transduction histidine ... 42 0.058
UniRef50_Q01Y41 Cluster: Putative GAF sensor protein; n=1; Solib... 42 0.058
UniRef50_A7HHY3 Cluster: Multi-sensor signal transduction histid... 42 0.058
UniRef50_A0GYK3 Cluster: Sensor protein; n=5; cellular organisms... 42 0.058
UniRef50_P73168 Cluster: Slr1385 protein; n=1; Synechocystis sp.... 42 0.077
UniRef50_A0Q276 Cluster: Sensor protein; n=1; Clostridium novyi ... 42 0.077
UniRef50_A2G8V4 Cluster: Putative uncharacterized protein; n=1; ... 42 0.077
UniRef50_UPI0000DAE83F Cluster: hypothetical protein Rgryl_01001... 42 0.10
UniRef50_Q8YYF0 Cluster: Sensor protein; n=7; Nostocaceae|Rep: S... 42 0.10
UniRef50_Q1D3G7 Cluster: Sensor protein; n=3; Cystobacterineae|R... 42 0.10
UniRef50_A1ZQI8 Cluster: Serine/threonine protein kinases; n=1; ... 42 0.10
UniRef50_A0GHR3 Cluster: Sensor protein; n=7; Proteobacteria|Rep... 42 0.10
UniRef50_Q8F629 Cluster: GGDEF domain protein; n=4; Leptospira|R... 41 0.13
UniRef50_Q82FJ5 Cluster: Putative two-component system sensor ki... 41 0.13
UniRef50_Q7TX69 Cluster: TWO COMPONENT SENSOR HISTIDINE KINASE D... 41 0.13
UniRef50_Q2K0G3 Cluster: Hypothetical conserved protein; n=2; Al... 41 0.13
UniRef50_Q0HSH5 Cluster: PTSINtr with GAF domain, PtsP; n=18; Sh... 41 0.13
UniRef50_Q09BC0 Cluster: Sensor protein; n=2; Stigmatella aurant... 41 0.13
UniRef50_A6G0W1 Cluster: Sensor protein; n=1; Plesiocystis pacif... 41 0.13
UniRef50_A5UPW4 Cluster: Sensor protein; n=2; Roseiflexus|Rep: S... 41 0.13
UniRef50_A4CFH5 Cluster: Putative orphan protein; putative GGDEF... 41 0.13
UniRef50_A3HS12 Cluster: Putative orphan protein ; putative GGDE... 41 0.13
UniRef50_A0LH02 Cluster: Transcriptional regulator, NifA subfami... 41 0.13
UniRef50_A0E4G9 Cluster: Chromosome undetermined scaffold_78, wh... 41 0.13
UniRef50_Q0W6Q5 Cluster: Sensor protein; n=1; uncultured methano... 41 0.13
UniRef50_UPI000038D7F7 Cluster: COG3605: Signal transduction pro... 41 0.18
UniRef50_Q9L708 Cluster: Sensor protein; n=3; Nostocaceae|Rep: S... 41 0.18
UniRef50_Q749X0 Cluster: HAMP domain/GAF domain/HD domain protei... 41 0.18
UniRef50_Q1YML1 Cluster: Putative adenylate/guanylate cyclase wi... 41 0.18
UniRef50_Q09B75 Cluster: Sensor protein; n=1; Stigmatella aurant... 41 0.18
UniRef50_A3ER00 Cluster: Transcriptional regulator containing GA... 41 0.18
UniRef50_A1I9E3 Cluster: Putative uncharacterized protein; n=1; ... 41 0.18
UniRef50_Q5SJL9 Cluster: GGDEF domain protein; n=2; Thermus ther... 40 0.23
UniRef50_A5FX95 Cluster: PTSINtr with GAF domain, PtsP; n=1; Aci... 40 0.23
UniRef50_A0Z9V8 Cluster: Sensor protein; n=1; Nodularia spumigen... 40 0.23
UniRef50_A2E3J3 Cluster: Putative uncharacterized protein; n=1; ... 40 0.23
UniRef50_A6G8U5 Cluster: Sensor protein; n=1; Plesiocystis pacif... 40 0.31
UniRef50_A4XM25 Cluster: GAF domain protein; n=1; Caldicellulosi... 40 0.31
UniRef50_A0ZM31 Cluster: Sensor protein; n=1; Nodularia spumigen... 40 0.31
UniRef50_Q6N7Z7 Cluster: Sensor protein; n=3; Rhodopseudomonas p... 40 0.41
UniRef50_Q67MH3 Cluster: Conserved domain protein; n=1; Symbioba... 40 0.41
UniRef50_Q0LIM1 Cluster: Histidine kinase, dimerisation and phos... 40 0.41
UniRef50_A6G1S4 Cluster: Putative adenylate cyclase; n=1; Plesio... 40 0.41
UniRef50_A3IV21 Cluster: Sensor protein; n=1; Cyanothece sp. CCY... 40 0.41
UniRef50_A2WIL5 Cluster: Sensor protein; n=2; Burkholderia cepac... 40 0.41
UniRef50_A1IE47 Cluster: Serine/threonine protein kinase and sig... 40 0.41
UniRef50_Q5QJ55 Cluster: PmoR; n=1; Mycobacterium sp. M156|Rep: ... 39 0.54
UniRef50_Q1VQE8 Cluster: Sensor protein; n=1; Psychroflexus torq... 39 0.54
UniRef50_Q0F2J5 Cluster: Sensor protein; n=1; Mariprofundus ferr... 39 0.54
UniRef50_A7HC49 Cluster: Transcriptional regulator, NifA subfami... 39 0.54
UniRef50_A1ZCG0 Cluster: Serine/threonine kinase with GAF domain... 39 0.54
UniRef50_A1ATH2 Cluster: Multi-sensor hybrid histidine kinase pr... 39 0.54
UniRef50_P91590 Cluster: Transglutiminase; n=1; Ciona intestinal... 39 0.54
UniRef50_Q8YYG4 Cluster: Sensor protein; n=4; Nostocaceae|Rep: S... 39 0.72
UniRef50_Q6FEW8 Cluster: Phosphoenolpyruvate-protein phosphotran... 39 0.72
UniRef50_Q3WGM8 Cluster: GAF:ATP-binding region, ATPase-like; n=... 39 0.72
UniRef50_Q1ASD1 Cluster: Diguanylate cyclase/phosphodiesterase w... 39 0.72
UniRef50_Q04ZE6 Cluster: ATPase/Protein kinase; n=3; Leptospira|... 39 0.72
UniRef50_A6W3M8 Cluster: GAF domain-containing protein; n=2; Mar... 39 0.72
UniRef50_A5NVV6 Cluster: Putative GAF sensor protein; n=1; Methy... 39 0.72
UniRef50_A5CY93 Cluster: Hypothetical signal transduction protei... 39 0.72
UniRef50_A4XBR6 Cluster: Diguanylate cyclase precursor; n=2; Sal... 39 0.72
UniRef50_A3QE18 Cluster: Diguanylate cyclase/phosphodiesterase w... 39 0.72
UniRef50_A0LJE0 Cluster: Putative GAF sensor protein; n=1; Syntr... 39 0.72
UniRef50_UPI000038DC38 Cluster: COG3899: Predicted ATPase; n=1; ... 38 0.95
UniRef50_Q9KBD4 Cluster: BH1994 protein; n=3; Bacillus|Rep: BH19... 38 0.95
UniRef50_Q8YN83 Cluster: Sensor protein; n=2; Nostocaceae|Rep: S... 38 0.95
UniRef50_Q1ARZ9 Cluster: Putative PAS/PAC sensor protein; n=1; R... 38 0.95
UniRef50_Q091Q8 Cluster: Sensor protein; n=2; Cystobacterineae|R... 38 0.95
>UniRef50_Q16HU8 Cluster: Camp and camp-inhibited cgmp 3,5-cyclic
phosphodiesterase; n=5; Eumetazoa|Rep: Camp and
camp-inhibited cgmp 3,5-cyclic phosphodiesterase - Aedes
aegypti (Yellowfever mosquito)
Length = 767
Score = 697 bits (1723), Expect = 0.0
Identities = 355/702 (50%), Positives = 475/702 (67%), Gaps = 31/702 (4%)
Query: 130 KNNAINDILKIYKEDPREHTVLWQLAKSVATSIGVETYRVYKLFPDHPTFVQHFVIDHTK 189
K + D++ + P + VLW+LA + +++ + +R+Y L H + ++
Sbjct: 72 KRQMLQDLIHSLQLRPTKMHVLWELASCICSAVNADGFRLY-LTDASDADALHLCLSNSF 130
Query: 190 LPQN-QPVPSTLERSDPQQVELVLEVAKKGTSKRVSRFDDPLRFPETPLSLLRSCNSRNK 248
+ +N P P + +SD + VAK R S+ DD RF + L
Sbjct: 131 IDENGDPKPLRI-KSD---AAIPNYVAKTREPIRFSKGDDDQRFNKDVLD--------KS 178
Query: 249 QGNYILYQPIITKSGKTSYVLEMWRTK--DRFKVIDEEISGHIVVWGSVALHYCKLYVDK 306
+ +++ QPI+ G VLE+WR F DEEI +VWG +A+HY L +
Sbjct: 179 EMAHVMCQPIVYPDGSLVAVLELWRRDCGSPFYEEDEEIGCSYLVWGGIAIHYAHLNLVG 238
Query: 307 KRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTV 366
++R ++DFLL VVK+IF++MVS+D L+ +++ FAQRLV+ADRASLFLVD ++ EL +T+
Sbjct: 239 LKQRKLNDFLLAVVKSIFQDMVSMDMLVSKVMNFAQRLVDADRASLFLVDSKSKELYATI 298
Query: 367 FDLKFEPGL-------DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVD 419
FD+ + +L+ KEIR P+ GIAG VA++GE +NI DAY+D RFNR +D
Sbjct: 299 FDVGCDEKTAMNENENELNKAPKEIRFPLGTGIAGQVAMTGEILNIVDAYADSRFNRTID 358
Query: 420 EATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
+ TGYKT SILCMPI + G +IGVVQMVNKR YF +DE AFE+F+ + GLALHHA+L
Sbjct: 359 QITGYKTESILCMPIFIRGNIIGVVQMVNKRSG-YFSKEDEEAFEMFAVYCGLALHHAKL 417
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFY-LDPFRFDEFEKC 538
YD+I R EQKYRVALEVLSYHNTC E EV+ L++ PL + D Y PF D+F+K
Sbjct: 418 YDKIRRSEQKYRVALEVLSYHNTCSESEVEHCLVEGIPLKIPGIDSYDFSPFVIDDFQKA 477
Query: 539 KCIISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKE 598
+ MF+DLF +++FD T+L RFTLTVKKNYR VPYHN+ HG++VA+ MY+I+K+
Sbjct: 478 IYSVFMFKDLFGLSRFDKTSLIRFTLTVKKNYRRVPYHNWTHGFSVANTMYSIIKN-CPH 536
Query: 599 RFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTIL 658
F N+ LALF+ LCHDLDHRG NK+M +T SPLAA+Y+TST+EHHHFN TVTIL
Sbjct: 537 VFRPNEC---LALFIGSLCHDLDHRGKNNKFMLDTESPLAAIYSTSTMEHHHFNQTVTIL 593
Query: 659 QQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSH 718
QQ+GHNIFS ++S +YK++L I+HCILATDLA FFPN DK+ +L D QFSW H
Sbjct: 594 QQEGHNIFSKLNSNEYKQVLSLIKHCILATDLALFFPNKDKLSKLV--DNEQFSWTVAEH 651
Query: 719 RDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEE 778
R L I+MT ADLSASAKPW +Q +TVKVIF EFYDQGD+E+ AGR PI MMDR++PE+
Sbjct: 652 RMLIQTIAMTGADLSASAKPWAVQTETVKVIFAEFYDQGDEEKKAGRQPIAMMDRDQPEQ 711
Query: 779 QPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
Q ASQ+GFL+ ICIPCY +L+R++P TKPM M +NL RW+
Sbjct: 712 QAASQLGFLNGICIPCYTLLHRLIPETKPMLTMCNENLERWQ 753
>UniRef50_P91119 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-5; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic
phosphodiesterase pde-5 - Caenorhabditis elegans
Length = 710
Score = 502 bits (1239), Expect = e-140
Identities = 259/487 (53%), Positives = 336/487 (68%), Gaps = 16/487 (3%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVF 367
++R +S+FLLDV ++IF ++VS+D +I +++ FAQ+LV+ADRASLFLVD +N+++ + +F
Sbjct: 213 KQRKLSNFLLDVARSIFHDIVSMDAVIIKVMNFAQKLVDADRASLFLVDSKNAQIYARIF 272
Query: 368 DLKF--EPGLDLDME-KKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
D+ E + ++ E +KEIR +++GIAG+VA +GE +NI +AY D RFN DVD TGY
Sbjct: 273 DVGTGDEEHVRVNSEGQKEIRFDMSKGIAGYVASTGEGLNIENAYEDERFNADVDSKTGY 332
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
T +ILCMPI + G VIGVVQMVNK D F DE AFEIF+ + GLALHHA+LYD+I
Sbjct: 333 TTKTILCMPILIRGIVIGVVQMVNKHDG-VFTRQDEDAFEIFAVYCGLALHHAKLYDKIR 391
Query: 485 RKEQKYRVALEVLSYHNTCREYEVQAML---LDKEPLNVDFADFYLDPFRFDEFEKCKCI 541
R EQKYRVALEVL+YH+ C EV + ++ + ++ DF + R E EK
Sbjct: 392 RSEQKYRVALEVLAYHSVCNADEVNKLKKIEINNRIVELETIDF--NGMRLSELEKPLYA 449
Query: 542 ISMFRDLF-DMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+ MF+ LF D +FD L RF LTV+KNYR V YHN+ HGW+VAHAM+A L + + F
Sbjct: 450 VYMFKTLFADTLRFDTEDLIRFVLTVRKNYRRVAYHNWAHGWSVAHAMFATLMNS-PDAF 508
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
+A LAL+V+CLCHDLDHRG N YM ++PLA++Y+TS +E HHFN TVTILQQ
Sbjct: 509 TKLEA---LALYVSCLCHDLDHRGKNNAYMKTMSTPLASIYSTSVMERHHFNQTVTILQQ 565
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRD 720
DGHNI +SSEDYK+ L I+HCILATDLA FF N K+ + D F + HR
Sbjct: 566 DGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSNKAKLNVIL--DNNTFDINRQEHRL 623
Query: 721 LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQP 780
L A+ MT DL ASAKPW IQ +TVKVIFEEFYDQGD ER +G+ PIPMMDR + P
Sbjct: 624 LTQAVMMTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAERLSGKEPIPMMDRQQAHMLP 683
Query: 781 ASQVGFL 787
Q L
Sbjct: 684 QMQASRL 690
>UniRef50_Q9Y233 Cluster: cAMP and cAMP-inhibited cGMP 3',5'-cyclic
phosphodiesterase 10A; n=44; Euteleostomi|Rep: cAMP and
cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A -
Homo sapiens (Human)
Length = 779
Score = 483 bits (1190), Expect = e-134
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.41
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 1.7
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>UniRef50_A7SW30 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 600
Score = 460 bits (1134), Expect = e-128
Identities = 232/558 (41%), Positives = 354/558 (63%), Gaps = 25/558 (4%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L QPII G V+E+ + F+ DEEI +VWGS+A+H+ ++ +++
Sbjct: 61 VLCQPIIQSDGTLVGVVELVKALGSMPFEKEDEEILNSYLVWGSIAIHHAEISKQITKQK 120
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
+++ FLL+VV++IF+E+ ++D +I++I+ FA++LVNADR SLFL+D + EL + +FD
Sbjct: 121 DLNTFLLNVVRSIFDEVCTMDTVIEKIMAFAKKLVNADRCSLFLLDQASEELFANLFDDG 180
Query: 371 FEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISIL 430
E G EIR P+++GIAG+VA +G +NI DAY D RFNR+VD TGY T +IL
Sbjct: 181 NEDGSFRC--GNEIRFPVSKGIAGYVACTGSILNIRDAYRDERFNREVDMKTGYTTHTIL 238
Query: 431 CMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKY 490
C+P++ +G +IGV QMVN + +F +D +FE+F+ + GLALH++++Y+ + +QK+
Sbjct: 239 CVPVRCKGSIIGVCQMVNSHNG-FFSPNDMQSFEMFAGYCGLALHYSKMYNSLFCAQQKH 297
Query: 491 RVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFD 550
+VALEV+SYH E E + L + AD + P + F +I +
Sbjct: 298 QVALEVISYHCCASEKETEEFL--------NSADLVMLPPAYYPFSYLSALIFVL----- 344
Query: 551 MTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLA 610
+ + D+ T+ RF+L+V+K YR +PYHN+ H ++VAH+++ +++ D K DY K L+
Sbjct: 345 IFRVDLETIARFSLSVRKCYRDIPYHNWCHAFSVAHSLWIVIR-DNKSLTDYEK----LS 399
Query: 611 LFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHIS 670
LF+A +CHD+DHRG N +M +PLA +YTTST+E HHF V IL+ +G N+F +
Sbjct: 400 LFIAGICHDVDHRGKNNAFMLHCKTPLANLYTTSTMEWHHFKQGVFILESEGQNVFGQLD 459
Query: 671 SEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAA 730
+E Y+ +L I+ I+ATDL FF N ++ L + F W++ HR L + MTA
Sbjct: 460 AESYRRVLELIQEAIIATDLMLFFGNKKELETL--QENKAFRWEEEKHRSLIRCLLMTAC 517
Query: 731 DLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQI 790
DL SAKPW+IQ+ V +FEEFY QGD+ER G P+PMMDR+K ++ P +QVGFL I
Sbjct: 518 DLCTSAKPWDIQVVAVNKVFEEFYIQGDEERKMGLDPLPMMDRSKHDDLPENQVGFLKGI 577
Query: 791 CIPCYDMLYRILPNTKPM 808
PCY +L +P P+
Sbjct: 578 VRPCYSLLMDFVPEMAPL 595
Score = 64.1 bits (149), Expect = 2e-08
Identities = 42/150 (28%), Positives = 72/150 (48%), Gaps = 7/150 (4%)
Query: 385 RMPINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP-IKVEGKVI 441
R PI +G +A HVA +GE + I D D RF + + +S+LC P I+ +G ++
Sbjct: 15 RQPIGKGGTVAAHVAETGERLFIKDILGDERFPKGIGVEGMTTAMSVLCQPIIQSDGTLV 74
Query: 442 GVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS--Y 499
GVV++V F +DE + + +A+HHA + +I +++ L V+ +
Sbjct: 75 GVVELVKALGSMPFEKEDEEILNSYLVWGSIAIHHAEISKQITKQKDLNTFLLNVVRSIF 134
Query: 500 HNTCREYEV--QAMLLDKEPLNVDFADFYL 527
C V + M K+ +N D +L
Sbjct: 135 DEVCTMDTVIEKIMAFAKKLVNADRCSLFL 164
>UniRef50_UPI0000588CD9 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 701
Score = 409 bits (1008), Expect = e-112
Identities = 226/581 (38%), Positives = 342/581 (58%), Gaps = 37/581 (6%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L P+I +G+ V+E+ R F +++I+G W ++AL DK +
Sbjct: 124 VLSLPLIQPNGEIVAVIELSRQVGSPPFTQQEKQIAGTYFTWVAIAL-------DKIQVE 176
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
NM + IF+++V++D L + I+ FA+ LV+ADR +LFLVD EL + FD
Sbjct: 177 NM--------QVIFDDIVAIDDLSQHIMMFAKSLVSADRCALFLVDTETEELYADQFDDG 228
Query: 371 FE-PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
+ G + ++K +IR P++RGIAGHVA +G+ +NIPDAY D RFNR+VD TGY T SI
Sbjct: 229 LDRDGKPVFVKKSQIRFPLSRGIAGHVAKTGDIVNIPDAYQDRRFNREVDVKTGYSTRSI 288
Query: 430 LCMPIKVEGKVIGVVQMVNK--RDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
LCMPI G +IGVVQM+NK +D + F DE+ F+IF+ + LALH +R+Y +
Sbjct: 289 LCMPITSHGLIIGVVQMINKMGQDGQTTAFDQTDESNFKIFAMYCALALHFSRIYRDSQQ 348
Query: 486 KEQKYRVALEVLSYHNTCREYEVQAML--LDKE----PLNVDFADFYLDPFRFDEFEKCK 539
E+ V E L Y+ TC E +V +L +K+ P ++ DF+ P+ E
Sbjct: 349 SERNLAVVQEQLIYYTTCSEQQVDRLLNSWNKQSFTVPTEIEQFDFHSRPYVSSLNE--- 405
Query: 540 CIISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKER 599
I M + LF + FD+TTL RF LTV+K+YR VP+HNF H + V H M+ IL + R
Sbjct: 406 IFIYMVQKLFGPSSFDLTTLARFILTVRKHYRLVPFHNFCHAFDVCHCMFMILLHS-EGR 464
Query: 600 FDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQ 659
F A+F +CHD+DHRG TN + ++ +PL +Y++S +E HHF + V+IL
Sbjct: 465 F---TDEEMYAMFFGSICHDMDHRGLTNSFHAKFGTPLGKLYSSSIMESHHFAMIVSILH 521
Query: 660 QDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHR 719
++G N+FSH+ + +K+I+ I+ I++TDL FFPN ++ +L + F W HR
Sbjct: 522 REGFNVFSHLPPDTFKKIVDLIQDIIMSTDLTNFFPNHKELSKLLVAQ--TFDWTIDHHR 579
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ MTA DL AS K W IQ + V+ ++EEFY QGD E+ G PI M+DR+ +
Sbjct: 580 WSIRNMCMTACDLCASTKMWPIQQQIVECLYEEFYSQGDIEKERGETPIQMLDRDNQPNR 639
Query: 780 PASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
Q+ FL+ +C+PC+ + +LP ++P+ + NL +W+
Sbjct: 640 AQEQIEFLTNVCLPCFSDIADLLPESQPLLSGCKDNLQQWQ 680
>UniRef50_Q9VJ79 Cluster: Dual 3',5'-cyclic-AMP and -GMP
phosphodiesterase 11; n=9; Eumetazoa|Rep: Dual
3',5'-cyclic-AMP and -GMP phosphodiesterase 11 -
Drosophila melanogaster (Fruit fly)
Length = 1451
Score = 373 bits (918), Expect = e-101
Identities = 217/627 (34%), Positives = 332/627 (52%), Gaps = 19/627 (3%)
Query: 218 GTSKRVSRFDDPLRFPETPLSLLRSCNSRNKQG---NYILYQPIITKSGKTSYVLEMWRT 274
G + V+ +P+ P+ +C + G +L PI SG V ++
Sbjct: 488 GIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINK 547
Query: 275 KDR--FKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQ 332
+ F IDE++ + + + L +LY + E + LLD+ + IFEE +++
Sbjct: 548 MNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEH 607
Query: 333 LIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKK----EIRMPI 388
++ RIL Q L+ R + LV + S VFD + + + + E R PI
Sbjct: 608 MVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPI 667
Query: 389 NRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGVVQMV 447
N GI GHVA +GET+N+P+AY D RF+ VDE + +K SILCM IK G++IGV+Q++
Sbjct: 668 NIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLI 727
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
NK ++ F +DE E F+ F G+ +H+ +Y++ + K V LEVLSYH + E
Sbjct: 728 NKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDE 787
Query: 508 VQAMLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFT 563
+ + P V F DF D F++ + K + MF DL + +F D L R+
Sbjct: 788 AHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWL 847
Query: 564 LTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHR 623
L+VKKNYR V YHN+ H + VA M+AIL + + + + LAL + CLCHDLDHR
Sbjct: 848 LSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKI-FGEIEC-LALIIGCLCHDLDHR 905
Query: 624 GYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
G N + + +SPLA +Y+TST+EHHHF+ + IL G+ I +++SS+DY ++ +
Sbjct: 906 GTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLED 965
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
IL+TDLA +F E + + ++P R L A+SMT DLSA KPWEI+
Sbjct: 966 AILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEK 1023
Query: 744 KTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL 802
+ ++ EF++QGD E+ I PI +M+R K +E P QV F+ IC+P Y+ +
Sbjct: 1024 RVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLS 1083
Query: 803 PNTKPMYAMATKNLNRWKARADKILFK 829
+P+ N W AD + K
Sbjct: 1084 DKLEPLVEGVRDNRGHWIDLADVVKTK 1110
Score = 134 bits (323), Expect = 1e-29
Identities = 77/204 (37%), Positives = 124/204 (60%), Gaps = 9/204 (4%)
Query: 301 KLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
+L ++ ++ + + + ++VK I E+ + L +IL+ L+NADR SLFLV R +
Sbjct: 392 RLSRNELKQLDEKELIFELVKDICNEL-EVRTLCHKILQNVSILLNADRGSLFLVQGRCN 450
Query: 361 E-------LVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYR 413
LVS +FD+ ++ ++ E+R+ GIAGHVA SGE +NIPDAY D R
Sbjct: 451 GPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDER 510
Query: 414 FNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGL 472
FN ++D TGY+T ++LCMPIK G VIGV Q++NK + + F + DE F + F G+
Sbjct: 511 FNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGI 570
Query: 473 ALHHARLYDRIMRKEQKYRVALEV 496
L +A+LY++ + ++ +V L++
Sbjct: 571 GLRNAQLYEKSQLEIKRNQVLLDL 594
>UniRef50_Q9HCR9 Cluster: Dual 3',5'-cyclic-AMP and -GMP
phosphodiesterase 11A; n=42; Eumetazoa|Rep: Dual
3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo
sapiens (Human)
Length = 934
Score = 367 bits (902), Expect = e-99
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 355 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 414
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 415 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 474
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 475 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 595 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 654
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 655 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 712
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 713 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 772
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 773 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 830
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 831 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 890
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 891 LKPMLDSVATNRSKWEELHQKRL 913
Score = 132 bits (319), Expect = 4e-29
Identities = 77/199 (38%), Positives = 119/199 (59%), Gaps = 9/199 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVS 364
++ N F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS
Sbjct: 197 KKHNERQFFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 365 TVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
FD+ L E+++P +GI G+V GET+NIPDAY D RFN ++D+
Sbjct: 256 KFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315
Query: 422 TGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++ F G+A+ +A+L
Sbjct: 316 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 375
Query: 480 YDRIMRKEQKYRVALEVLS 498
+ ++ ++ R LEV++
Sbjct: 376 FAASRKEYERSRALLEVVN 394
>UniRef50_O00408 Cluster: cGMP-dependent 3',5'-cyclic
phosphodiesterase; n=47; Eumetazoa|Rep: cGMP-dependent
3',5'-cyclic phosphodiesterase - Homo sapiens (Human)
Length = 941
Score = 346 bits (850), Expect = 2e-93
Identities = 200/563 (35%), Positives = 309/563 (54%), Gaps = 22/563 (3%)
Query: 276 DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIK 335
D F DE + H + S L + +++ + LL V K +F + + L++
Sbjct: 356 DLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQ 415
Query: 336 RILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGH 395
I+ A+ L NA+ S+FL+D +ELV+ VFD G +D E EIR+P ++GIAGH
Sbjct: 416 EIITEARNLSNAEICSVFLLD--QNELVAKVFD-----GGVVDDESYEIRIPADQGIAGH 468
Query: 396 VALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKRDDKY 454
VA +G+ +NIPDAY+ F R VD++TG++T +ILC PIK E +VIGV ++VNK + +
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 455 FGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLD 514
F DE FS + G+++ H+ LY ++ + + +A E++ YH + E +L D
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 515 K-EP---LNVDFADFYLDPFRFDEFEKCKCIISMFRDL--FDMTQFDITTLTRFTLTVKK 568
+P ++ +FA F P E + I+SM +D+ + + D TL RF L VKK
Sbjct: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKK 648
Query: 569 NYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNK 628
YR PYHN+ H ++V+H Y + K+ E +Y + ALF++C+CHDLDHRG N
Sbjct: 649 GYRDPPYHNWMHAFSVSHFCYLLYKN--LELTNYLEDIEIFALFISCMCHDLDHRGTNNS 706
Query: 629 YMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
+ + S LAA+Y++ S +E HHF + IL G NIF H S +DY+ +L +R IL
Sbjct: 707 FQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIIL 766
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATDLA +L ++L + E + ++ H L + + MT+ DLS K W+ K
Sbjct: 767 ATDLA---HHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIA 823
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
++I++EF+ QGD E+A G P+ MMDR K P Q+ F+ I +P Y +L + P
Sbjct: 824 ELIYKEFFSQGDLEKAMGNRPMEMMDREK-AYIPELQISFMEHIAMPIYKLLQDLFPKAA 882
Query: 807 PMYAMATKNLNRWKARADKILFK 829
+Y N W + K +
Sbjct: 883 ELYERVASNREHWTKVSHKFTIR 905
>UniRef50_UPI00015B4531 Cluster: PREDICTED: similar to cyclic GMP
stimulated phosphodiesterase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to cyclic GMP
stimulated phosphodiesterase - Nasonia vitripennis
Length = 1684
Score = 345 bits (848), Expect = 3e-93
Identities = 185/511 (36%), Positives = 300/511 (58%), Gaps = 16/511 (3%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL V K +F + L L++ I+ A++L A+R SLFL++ ELV+ VFD GL
Sbjct: 176 LLVVSKKLFTRLGDLTDLLREIMTEARKLTKAERCSLFLLESEQQELVAKVFD-----GL 230
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
+ +E+R+ + +GIAGHVA +G+ +NI +AY F R +DE TG+KT +ILC PI+
Sbjct: 231 PTEESAQEMRISLGQGIAGHVATTGKLLNIRNAYEHPLFYRGIDEVTGFKTRNILCFPIR 290
Query: 436 VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALE 495
E +IGV Q+ NK + YF DE FS + G+++ H+ +Y +I + + +++ E
Sbjct: 291 DENGIIGVAQLCNKINGLYFDVFDEEVAMAFSIYCGISIMHSIVYKKIQDAQARSKLSNE 350
Query: 496 VLSYHNTCREYEVQAMLLDKEPLNV-DFADFYLDPFRFDEFEKCKC-IISMFRDLFDMTQ 553
++ YH E +VQA+L + N+ DF F+ P R + C ++ MF DL + +
Sbjct: 351 LMMYHMQVEEEDVQALLNCGDDHNIKDFDTFHFCP-RTVPYRHMPCYVLKMFADLNFIRR 409
Query: 554 FDI--TTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLAL 611
+ I T L RF L VKK YR PYHN+ H ++VAH Y ++K+ R Y + L
Sbjct: 410 WKIRKTVLARFILYVKKGYRDAPYHNWMHAFSVAHFAYLLMKNLNLVRDGYMTSLQALVF 469
Query: 612 FVACLCHDLDHRGYTNKYMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHI 669
V+CLCHD+DHRG N + ++ + LA++Y++ S +E HH ++ IL +G NIF ++
Sbjct: 470 LVSCLCHDIDHRGTNNSFQTKCGTILASLYSSEGSVMERHHLAQSMCILNTEGCNIFENL 529
Query: 670 SSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTA 729
SSE+Y E L +R+ ILATDLA+ F ++++ R++ + + ++P H+ + A+ MT
Sbjct: 530 SSEEYSEALDLLRNNILATDLASHFRSVEEQRDVTKQG---YDKNNPKHQKILHAMFMTC 586
Query: 730 ADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQ 789
DL+ K W + +T + I++EF+ QGD E++ G PI MMDR + P QV F++
Sbjct: 587 CDLNDQTKNWRVSKQTAEQIYDEFFSQGDLEKSMGTAPIEMMDRER-ASIPDLQVQFITN 645
Query: 790 ICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ +P + L + P+ +P+ + +N W+
Sbjct: 646 LVLPLFTNLATLFPSMQPIVHIIERNREIWR 676
>UniRef50_UPI0000E48F4D Cluster: PREDICTED: similar to camp and
camp-inhibited cgmp 3,5-cyclic phosphodiesterase; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
camp and camp-inhibited cgmp 3,5-cyclic
phosphodiesterase - Strongylocentrotus purpuratus
Length = 1197
Score = 344 bits (846), Expect = 6e-93
Identities = 156/265 (58%), Positives = 203/265 (76%), Gaps = 5/265 (1%)
Query: 554 FDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFV 613
FD L RF LTV+KNYR VPYHN+ H ++VAH++Y ++ + + F+ +A LALFV
Sbjct: 12 FDYDELCRFILTVRKNYRRVPYHNWTHAFSVAHSVYTMIMTGQGQVFNPLEA---LALFV 68
Query: 614 ACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSED 673
ACLCHDLDHRG N +M TASPLA++Y+TST+EHHHFN+T+TILQ DGHNIF H+SSE+
Sbjct: 69 ACLCHDLDHRGKNNAFMVNTASPLASVYSTSTMEHHHFNMTITILQNDGHNIFKHLSSEE 128
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLS 733
YK++LG IRH ILATDLA FFPN K++++ +E FSWD+ HR A+SMTA DL+
Sbjct: 129 YKQVLGDIRHAILATDLALFFPNKAKLKKIV--EEKNFSWDNQEHRQCVKALSMTACDLA 186
Query: 734 ASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIP 793
A+ KPW IQ +TVKVIF+EFY QGD+E+AAGR PIPMMDR++ E PA+QV F+ IC+P
Sbjct: 187 ANTKPWHIQQQTVKVIFDEFYQQGDEEKAAGRNPIPMMDRDRAHELPANQVSFIVGICLP 246
Query: 794 CYDMLYRILPNTKPMYAMATKNLNR 818
CYD+L +++P+ KPMY A N+
Sbjct: 247 CYDLLAQLVPSAKPMYEGAASMNNK 271
>UniRef50_Q9VFI9 Cluster: CG8279-PA; n=8; Endopterygota|Rep:
CG8279-PA - Drosophila melanogaster (Fruit fly)
Length = 1131
Score = 336 bits (826), Expect = 2e-90
Identities = 180/444 (40%), Positives = 256/444 (57%), Gaps = 15/444 (3%)
Query: 392 IAGHVALSGETMNIPDAYS---DYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
IA VA +G+T+NI D D+ R DE T +ILCMPI + KVIGV Q++
Sbjct: 541 IAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDS--TQAILCMPIMNAQKKVIGVAQLI 598
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
NK + F D D + FE F+ F GL +H+ ++Y+ + K +VALE LSYH T + +
Sbjct: 599 NKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQ 658
Query: 508 VQAMLLD--KEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFT 563
+ + D E + + F F + + C+ ++ MF ++QF I L R+
Sbjct: 659 TEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWV 718
Query: 564 LTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHR 623
L+V+KNYR V YHN+ H VA M+A+LK+ ERF + L L VACLCHDLDHR
Sbjct: 719 LSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEI--LGLLVACLCHDLDHR 776
Query: 624 GYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
G N + ++T SPLA +YTTST+EHHHF+ V IL +G+NIF +S EDY+ ++ +
Sbjct: 777 GTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVES 836
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
IL+TDLA +F + EL + E F W +DL + MTA D+SA AKPWE+Q
Sbjct: 837 AILSTDLAMYFKKRNAFLELVENGE--FDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQH 894
Query: 744 KTVKVIFEEFYDQGDKER-AAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL 802
K K++ +EF+DQGD E+ P+ MMDR + +E P QVGF+ IC+P Y +L
Sbjct: 895 KVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTF 954
Query: 803 PNTKPMYAMATKNLNRWKARADKI 826
P P+Y +N W+ A+K+
Sbjct: 955 PWITPLYEGTLENRRNWQDLAEKV 978
Score = 107 bits (258), Expect = 1e-21
Identities = 65/190 (34%), Positives = 111/190 (58%), Gaps = 8/190 (4%)
Query: 314 DFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR--NSELVSTVFDLKF 371
+ +++++ + E+ +D L +IL L +ADR SLFL N LV+ +FD+
Sbjct: 246 ELFMELIRDVANEL-DIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQ 304
Query: 372 EPGLDLDMEK---KEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L + + +EI +P GIAG VA + + +NI +AY D RFN ++D TGYKT +
Sbjct: 305 KTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNA 364
Query: 429 ILCMPI-KVEGKVIGVVQMVNKRDD-KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
ILCMPI EG +IGV Q++NK + F + D F + TF G+ + +A+L++ +++
Sbjct: 365 ILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQE 424
Query: 487 EQKYRVALEV 496
++ ++ L +
Sbjct: 425 YRRNQILLNL 434
Score = 46.4 bits (105), Expect = 0.004
Identities = 30/109 (27%), Positives = 54/109 (49%), Gaps = 3/109 (2%)
Query: 251 NYILYQPIITKSGKTSYVLEMWRTKDRFKVIDE---EISGHIVVWGSVALHYCKLYVDKK 307
N IL PI G V ++ + DE EI + + + + +L+
Sbjct: 363 NAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSV 422
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVD 356
+E + LL++ ++IFEE +L+ L+ +I+ A+ L+ +R S+FLVD
Sbjct: 423 QEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVD 471
>UniRef50_Q3SBD3 Cluster: Sperm phosphodiesterase 5; n=1;
Strongylocentrotus purpuratus|Rep: Sperm
phosphodiesterase 5 - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 949
Score = 335 bits (824), Expect = 3e-90
Identities = 202/586 (34%), Positives = 308/586 (52%), Gaps = 43/586 (7%)
Query: 278 FKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRI 337
F DEE+ + + + + + +L+ E + LL + + IFEE SLD ++ +I
Sbjct: 282 FNPADEEVFKNYLTFCGIGIMNAQLFEMSVNEYKRNQMLLQLARGIFEEQTSLDNVVHKI 341
Query: 338 LEFAQRLVNADRASLFLVDY----------------RNSELVSTVFD--------LKFEP 373
+ A L+ R +F+++ R+S + FD + F
Sbjct: 342 MRQAVSLLKCQRCMVFILETTEESYLPAQLRMAEGKRHSIAYQSSFDAPLNDVKNISFLK 401
Query: 374 GLDL---DMEKKE------IRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
G +L D EK + ++ IN IA HVA SGET NI D +F D +
Sbjct: 402 GFELTDEDTEKLKTIPHEMLKNSINATIARHVADSGETTNIADFTVQKQFKEISDVDPEF 461
Query: 425 KTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
+ S+LC PI E K+IGV QM+NK + F D DE FE F+ F GL +H+ ++++
Sbjct: 462 RIRSVLCQPIYNSEQKIIGVAQMINKACKQTFTDQDEHLFEAFAIFCGLGIHNTQMFENA 521
Query: 484 MRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPL--NVDFADFYLDPFRFDEFEKCKCI 541
MR K +VAL+VLSYH T + EV + P + +F F E + +
Sbjct: 522 MRLMAKQQVALDVLSYHATAQPDEVSKLKKSCVPSARELKLYEFSFSDFDLTEDQTLQGT 581
Query: 542 ISMFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKER 599
+ MF + L + L R+TL+V+KNYR V YHN+ H + VA M++I+ + +
Sbjct: 582 LRMFIECNLIEKYHIPYDVLCRWTLSVRKNYRPVIYHNWRHAFNVAQTMFSIVMTGKLRK 641
Query: 600 FDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQ 659
+ AL VACLCHDLDHRG N + +T+SPL+ +Y TST+EHHHF+ + IL
Sbjct: 642 LLTDLEI--FALIVACLCHDLDHRGTNNTFQVKTSSPLSLLYGTSTMEHHHFDHCIMILN 699
Query: 660 QDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHR 719
+G+NIF +S +DY+E + + IL+TDLA +F +L ++ + +WD+ +
Sbjct: 700 SEGNNIFEFMSPDDYREAIRMLESAILSTDLAIYFKKRADFFKLV--EKGEHTWDNEEKK 757
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKER-AAGRIPIPMMDRNKPEE 778
L + MTA D+SA AKPW +Q K +++F EF+ QGD ER P+ MMDR K +E
Sbjct: 758 GLLRGMLMTACDVSAIAKPWLVQQKVAELVFSEFFQQGDLEREKLKEEPMAMMDRKKKDE 817
Query: 779 QPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
P QVGF+ IC+P Y M + P+ KP+ + N + W+A ++
Sbjct: 818 LPKMQVGFIDGICMPVYKMFAELWPDLKPLESGTQLNRDNWQALSE 863
Score = 113 bits (273), Expect = 2e-23
Identities = 66/165 (40%), Positives = 101/165 (61%), Gaps = 8/165 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE--LVST 365
R+ + + +++++ I +E+ L+ L +IL L N DR SLFL LVS
Sbjct: 111 RQLDEKELFMELIRDIADEL-DLNTLCHKILMNVSILTNGDRCSLFLARGTKDRRFLVSK 169
Query: 366 VFDLKFEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATG 423
+FD+ ++ L E++EI +P +GIAGHVA + ET+NI +AY D RFN +VD+ TG
Sbjct: 170 LFDVNENSTVEDSLHSEEEEIHIPFGQGIAGHVAQTKETVNIKNAYEDKRFNPEVDKITG 229
Query: 424 YKTISILCMPI-KVEGKVIGVVQMVNK--RDDKYFGDDDEAAFEI 465
YKT SI+CMPI +G+V+GV Q++NK ++ D+EA E+
Sbjct: 230 YKTHSIMCMPICNHDGEVVGVAQVINKITGSHEFAAKDEEAQVEL 274
>UniRef50_Q7Q8G2 Cluster: ENSANGP00000013023; n=2; Diptera|Rep:
ENSANGP00000013023 - Anopheles gambiae str. PEST
Length = 747
Score = 329 bits (809), Expect = 2e-88
Identities = 211/604 (34%), Positives = 301/604 (49%), Gaps = 40/604 (6%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTK-DR-FKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI SG V ++ + D+ F DE+I + + + L +LY + E
Sbjct: 139 LLCMPIKDASGDVVGVAQVINKQGDQCFSTADEKIFSSYLQFCGIGLRNAQLYEKSQLEV 198
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
+ LLD+ + IFEE +++ ++ RIL Q L+ R + LV + S VFD +
Sbjct: 199 KRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEASKGSFSRVFDFE 258
Query: 371 FEP--GLDLDMEKK--EIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
G D D E R PIN GI G+VA +GET+NI +AY D RF+ VDE ++
Sbjct: 259 ANDLSGEDGDARTSPFESRFPINVGITGYVATTGETVNICNAYEDDRFDPSVDEGLNFRH 318
Query: 427 ISILCMPIKVE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG-------------- 471
+ILCM IK ++IGV+Q++NK DD F +DE E F+ F G
Sbjct: 319 KTILCMAIKNSLSQIIGVIQLINKFDDLTFTKNDENFVEAFAIFCGMGIHNTHMYEKAII 378
Query: 472 -----------LALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNV 520
L+ H + D R + LE + +H L K P +
Sbjct: 379 AMAKQSVTLEVLSYHASATIDDAYRLRVTCTLRLEFVCFHKALTLIFNLLQQL-KVPSSA 437
Query: 521 DFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYH 576
F DF D D+ K + MF DL + +F I L R+ L+VKKNYR V YH
Sbjct: 438 FFKLYDFKFDDLTLDDDHTLKACLRMFLDLDLVERFHIEYEVLCRWLLSVKKNYRNVTYH 497
Query: 577 NFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASP 636
N+ H + V M+AIL S + + + LAL +ACLCHDLDHRG N + + +SP
Sbjct: 498 NWRHAFNVTQMMFAILTSTQWWKI-FGEIEC-LALIIACLCHDLDHRGTNNSFQIKASSP 555
Query: 637 LAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN 696
LA +Y+TST+EHHHF+ + I+ G+ I S++SSEDY ++ + IL+TDLA +F
Sbjct: 556 LAQLYSTSTMEHHHFDQCLMIINSPGNQILSNMSSEDYSRVIRVLEDAILSTDLAVYFRK 615
Query: 697 LDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQ 756
L SW R L A+SMT DLSA KPWEI+ + ++ EF++Q
Sbjct: 616 RGAFLNLVEPASEMSSWQAEEPRSLLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQ 675
Query: 757 GDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKN 815
GD ER I PI +M+R K ++ P QVGF+ ICIP Y+ + P+ +N
Sbjct: 676 GDMERQELNITPIDIMNREKEDQLPMMQVGFIDSICIPIYEAFATLSDKLTPLIDGVREN 735
Query: 816 LNRW 819
W
Sbjct: 736 KQHW 739
Score = 138 bits (333), Expect = 8e-31
Identities = 77/205 (37%), Positives = 124/205 (60%), Gaps = 10/205 (4%)
Query: 301 KLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV----- 355
+L ++ ++ + + + ++VK I ++ + L +IL+ L+NADR SLFLV
Sbjct: 4 RLSRNELKQLDERELIFELVKDICNDL-DVRSLCHKILQNVSILLNADRGSLFLVQGKST 62
Query: 356 ---DYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDY 412
D LVS +FD+ L+ ++ E+++ GIAGHVA SGE +NIPDAY D
Sbjct: 63 CGGDNTKKCLVSKLFDVCSNSTLEEMEQQDEVKVAWGTGIAGHVAESGEPVNIPDAYQDE 122
Query: 413 RFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG 471
RFNR++D TGY+T ++LCMPIK G V+GV Q++NK+ D+ F DE F + F G
Sbjct: 123 RFNREIDVQTGYRTKALLCMPIKDASGDVVGVAQVINKQGDQCFSTADEKIFSSYLQFCG 182
Query: 472 LALHHARLYDRIMRKEQKYRVALEV 496
+ L +A+LY++ + ++ +V L++
Sbjct: 183 IGLRNAQLYEKSQLEVKRNQVLLDL 207
>UniRef50_UPI0000D555D7 Cluster: PREDICTED: similar to
phosphodiesterase 10A; n=4; Tribolium castaneum|Rep:
PREDICTED: similar to phosphodiesterase 10A - Tribolium
castaneum
Length = 745
Score = 322 bits (790), Expect = 4e-86
Identities = 187/575 (32%), Positives = 319/575 (55%), Gaps = 19/575 (3%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L P++T G+ V+E++R + F D +I+ + W A+H + +R++
Sbjct: 181 VLCVPVVTPDGECFAVIELYRQLFDEPFSKDDLKITLIVTGWMGAAIHQNSRRLALQRQQ 240
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE-LVSTVFDL 369
++D+LLD+ K F E V ++++I I+ FA+ +NA++ ++F++D + + LV+ ++D
Sbjct: 241 ELNDYLLDLTKCFFGESVVMEKMISEIVNFAKVTLNAEKGTIFIIDRDSGDDLVADMYD- 299
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + +K +R RGIA VA SG T+N+ DAY D RFN+++D+ TG+ T SI
Sbjct: 300 DTEDGKEFKKAQK-VRFSKERGIASLVARSGITVNVKDAYKDARFNKEIDQKTGFITRSI 358
Query: 430 LCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
LCMPI VEG ++GVVQ+VNK+ +F DE+ F F + LAL ++ R+
Sbjct: 359 LCMPIVGVEG-ILGVVQVVNKKRGGHFTSTDESLFRTFCVYCALALRFTKVQKRMQSTRL 417
Query: 489 KYRVALEVLSYH-NTCREYEVQAMLLDKE-PLNVDFADFYLDPFRFDEFEKCKCIISMFR 546
L+++ C + + + + + +DF F D + + I+ MF
Sbjct: 418 LNNCFLKMIQLQVKPCIHDIITYNVANSQVVIPMDFDHFGWHINTEDHPKMPQYILYMFL 477
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
L T + + L+VKK YR PYHNF+H + V H MY ILK ++K+ + +
Sbjct: 478 QLIKNTLHPERCI-HYILSVKKFYRRNPYHNFEHAFNVVHCMYLILKRNIKQ---FTETE 533
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIF 666
+ AL +A LCHD+DH G+TN ++ + + LA +Y S LE+H + + + +L D + +
Sbjct: 534 IK-ALMIAALCHDVDHPGFTNNFLELSNNDLANLYENSCLENHQYYVAMLLL--DHNKVL 590
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
+H+S E+Y+ + I+ I+ATD +F N + ++ + F W + +HR
Sbjct: 591 THLSKEEYEVLRTEIKQAIIATDPLVYFANQINLEKICNTH--SFDWGNETHRYYLKGTM 648
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
M ADLS KP+ + + ++ E Y QGD E+ G P+ MMDR+K P QV F
Sbjct: 649 MMVADLSGMCKPFLVSKRITDNLYAECYLQGDLEKEMGLCPLSMMDRDKSNFIPEDQVTF 708
Query: 787 LSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKA 821
++ + +PC D+L ++LPNT+ +Y+ TK++ +K+
Sbjct: 709 ITTVILPCLDILAQLLPNTEALYS-DTKSVLSFKS 742
>UniRef50_O76074 Cluster: cGMP-specific 3',5'-cyclic
phosphodiesterase; n=47; Euteleostomi|Rep: cGMP-specific
3',5'-cyclic phosphodiesterase - Homo sapiens (Human)
Length = 875
Score = 319 bits (784), Expect = 2e-85
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 5e-28
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>UniRef50_Q4SVG8 Cluster: Chromosome undetermined SCAF13758, whole
genome shotgun sequence; n=4; Tetraodontidae|Rep:
Chromosome undetermined SCAF13758, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 928
Score = 303 bits (745), Expect = 1e-80
Identities = 187/530 (35%), Positives = 280/530 (52%), Gaps = 25/530 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEP-G 374
LLD+ +F+E L+ L+++ + A ++F+ D + S+VF ++ E G
Sbjct: 395 LLDLASLLFQEQQCLEVLLRKFAGTILSFMQAQACTVFIADPDSMNSFSSVFHMENEELG 454
Query: 375 LDLDMEKKEIRMP-INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA--TGYKTISILC 431
D+ K++ + +N A +V + +T+NI D D RF + A + + S+LC
Sbjct: 455 EVPDVPKRDADVSQMNYMYAQYVKNTMQTLNIADVSKDQRFPWTGENADVSNDQIKSLLC 514
Query: 432 MPIK--VEGKVIGVVQMVNKRDD----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
PI+ + KVIGV Q+VNK D+ K F +DE E F+ F GL + + ++Y+R+ R
Sbjct: 515 TPIRNGKKDKVIGVCQLVNKMDEADSVKTFNRNDEQFLEAFAIFCGLGIQNTQMYERVER 574
Query: 486 KEQKYRVALEVLSYHNTC-----REYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKC 540
K V LEVLSYH T RE +V ++ DF F + E
Sbjct: 575 AMAKQEVTLEVLSYHATASEEESRELQVTVGATVPSAQSLSLLDFSFSDFELSDMETTLA 634
Query: 541 IISMFRDLFDMTQFDI--TTLTRFTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVK 597
+ MF DL + F + T L R+ L++KKNYR +V YHN+ H + A +M+A+LKS
Sbjct: 635 TVRMFVDLDLVQNFQMKYTNLCRWVLSIKKNYRKSVAYHNWRHAFNTAQSMFALLKSG-- 692
Query: 598 ERFDYNKASSR-LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVT 656
R LAL +A L HDLDHRG N Y+ + PLA +Y ST+EHHHF+ +
Sbjct: 693 -RLQNELTDLEVLALMIATLSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDHCLM 751
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDP 716
IL G+ I S +S ++YK L I ILATDLA + EL ++ +QF W+D
Sbjct: 752 ILNSPGNQILSGLSLDEYKSTLKMIERAILATDLALHMKRRGEFFELTKN--SQFRWEDE 809
Query: 717 SHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNK 775
HRDL ++ MTA D+SA KPW +Q + +++ EF++QGDKER I P +M+R K
Sbjct: 810 GHRDLLRSMLMTACDISAITKPWPVQQRIAELVATEFFEQGDKERRELNIEPSDLMNREK 869
Query: 776 PEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
++ P+ QV F+ IC Y L + P+ KN +WK A++
Sbjct: 870 KDKIPSMQVSFIDAICTQLYQTLAGMSEYCSPLLEGCRKNREQWKHLAEE 919
Score = 101 bits (241), Expect = 1e-19
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 11/152 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK + + + L +I L+ ADR SLFLV D N + L+S +FD+ E
Sbjct: 129 LLELVKEVSSHL-DVTALCHKIFLHTNELIAADRYSLFLVGEDSSNQKFLLSRLFDVA-E 186
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
+ IR+ N+GI GHVA +G+ +NI +AY D RFN +VD TGYKT SILC+
Sbjct: 187 GSTVEETSSSCIRLDWNKGIVGHVAATGQPLNIRNAYQDSRFNAEVDLITGYKTQSILCL 246
Query: 433 PIKVE-GKVIGVVQMVNKRDDKYFGDDDEAAF 463
PIK + +V+GV Q +NK+ D EAAF
Sbjct: 247 PIKNQRDEVVGVAQAINKK-----SSDGEAAF 273
>UniRef50_O96076 Cluster: EFPDE2; n=1; Ephydatia fluviatilis|Rep:
EFPDE2 - Ephydatia fluviatilis
Length = 819
Score = 302 bits (742), Expect = 2e-80
Identities = 188/557 (33%), Positives = 293/557 (52%), Gaps = 23/557 (4%)
Query: 273 RTKDR-FKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLD 331
+ DR F DEE + + + S L+ +Y + + ++ LL V K +F + +L
Sbjct: 260 KNNDRPFTKHDEEGLLYSLHFCSSMLNNTLVYQRELALKKQNEVLLQVAKNLFTSLDNLV 319
Query: 332 QLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRG 391
L++ I+ A L NA+R SLFL+D S LV+TVF+ G D+ ++++ + + + +G
Sbjct: 320 SLLRGIMNAASSLTNAERCSLFLLDKSRSNLVATVFN-----G-DV-LKERTLTIKVGQG 372
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGVVQMVNKR 450
IAG+VA +G +NI DA +F +VD++TG+ T ILC PI G V+GV ++ NK
Sbjct: 373 IAGYVAKTGTIVNIVDAQKHPQFFAEVDKSTGFHTKHILCFPIMDNNGVVVGVAELCNKI 432
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
+ K+F DE FS + G++++H++LY+ +M + + +A E++ YH R E++
Sbjct: 433 NGKFFTKYDEELARTFSAYCGISIYHSKLYETVMASQGRSSLATELMLYHMKIRPDELER 492
Query: 511 MLLDKEPLNVDFADFY----LDPFRFDEFEKCKCIISMFR--DLFDMTQFDITTLTRFTL 564
P F + P ++SM DL + Q L RF +
Sbjct: 493 ATKTPLPPVSSFHEHMCKLTFSPLDIKNSADEIAVMSMMNEMDLINKFQLHPDILARFVI 552
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
VKK YR PYHN+ H ++VAH +YA+ K LALFV+CLCHD+DHRG
Sbjct: 553 MVKKGYRDPPYHNWMHAFSVAHFLYALYCCSSK--LSCLDDLEVLALFVSCLCHDIDHRG 610
Query: 625 YTNKYMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIR 682
N + + S LA +Y++ S +E HH T+ IL G NIF ++S DY+ + I+
Sbjct: 611 TNNAFQVCSNSTLACLYSSEGSVMERHHLAQTLCILNSPGCNIFENLSDSDYRTTIQLIQ 670
Query: 683 HCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQ 742
IL TD+A+ L I+++ + +P H L ++ MT+ DL+AS K WE
Sbjct: 671 DNILDTDIASHLKKLKHIKQMANDG---YERSNPEHHRLMCSLIMTSCDLTASCKTWESN 727
Query: 743 IKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL 802
+I++EF+ QGD E+A G P MMDR++ P Q+ FL I P Y +L R+L
Sbjct: 728 KAISDLIYQEFFSQGDLEKALGVTPSEMMDRDR-AFIPEQQLQFLDNIAGPVYQLLSRLL 786
Query: 803 PNTKPMYAMATKNLNRW 819
P + Y N +W
Sbjct: 787 PESAAAYHTLLDNREQW 803
Score = 80.6 bits (190), Expect = 2e-13
Identities = 59/201 (29%), Positives = 104/201 (51%), Gaps = 19/201 (9%)
Query: 303 YVDKKRERNMSDFLLDVVKAIFE-EMVSLD-QLIKRILEFAQRLVNADRASLFLVDYRNS 360
+++ + E+ D +L V + + ++VSL +++K I+E + NA +LF+ +
Sbjct: 119 HLNSEHEKKRIDNMLRVCGELIDLDVVSLSIKILKHIMEVS----NAKACTLFVYEDVTQ 174
Query: 361 ELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDE 420
ELV+ ++ G+ LD KEIR P++ I G +GE +NI + D RFN +D
Sbjct: 175 ELVAYTYN-----GVPLD---KEIRKPVSSSIYGECFTTGEIINISNVPQDMRFNPRIDT 226
Query: 421 ATGYKTISILCMPIKVEG-----KVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALH 475
GY+ +LC+P+K G VIGV+ + +K +D+ F DE F L+
Sbjct: 227 IKGYEPTHLLCIPVKDRGAQGSQSVIGVLVVCDKNNDRPFTKHDEEGLLYSLHFCSSMLN 286
Query: 476 HARLYDRIMRKEQKYRVALEV 496
+ +Y R + +++ V L+V
Sbjct: 287 NTLVYQRELALKKQNEVLLQV 307
>UniRef50_Q17L35 Cluster: Cgmp-dependent 3,5-cyclic
phosphodiesterase; n=2; Culicidae|Rep: Cgmp-dependent
3,5-cyclic phosphodiesterase - Aedes aegypti
(Yellowfever mosquito)
Length = 502
Score = 282 bits (692), Expect = 3e-74
Identities = 177/493 (35%), Positives = 272/493 (55%), Gaps = 32/493 (6%)
Query: 341 AQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSG 400
A+ L A+R SLFL+D + ELVS VFD G + KEIR+ +GIAG+VA +G
Sbjct: 4 AKELAAAERCSLFLLDKQTGELVSKVFD-----GNEAS---KEIRIASGKGIAGYVAQTG 55
Query: 401 ETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDE 460
+NI +AY F + VDE+TG+KT +ILC PI E VIGV Q+ NK + +F DE
Sbjct: 56 NLLNIRNAYQHPLFYKGVDESTGFKTRNILCFPICDEQGVIGVAQLCNKLNGFHFDKCDE 115
Query: 461 AAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNV 520
FS + G+++ HA ++ ++ + E +Y+++ E+L YH + E+Q +L E +N
Sbjct: 116 EVATAFSVYCGISIMHALVHKQVQKAEARYKLSQELLLYHMKVPDTEIQHVL---EAVNA 172
Query: 521 DFAD-FYLDPFRFD----EFE----KCKCIISMFRDLFDMTQFDI--TTLTRFTLTVKKN 569
AD F +D RFD E + + I MF DL +T F I L RF L V+K
Sbjct: 173 HEADQFAMDLPRFDFCPREVKNYALSVQLSIKMFYDLNFVTTFQIPEDKLARFILLVQKG 232
Query: 570 YRTVPYHNFDHGWTVAHAMYAILKS-DVKERFDYNKASSRLALFVACLCHDLDHRGYTNK 628
YR PYHN+ H ++VAH Y+++ + + E K + +A CHDLDHRG +N
Sbjct: 233 YRDTPYHNWWHAFSVAHFAYSLMVNLKLIENGVITKMQG-FSFLIAAFCHDLDHRGTSNT 291
Query: 629 YMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
Y ++++SPLA +Y++ S E HH + + IL I +S+E++KE + F+R IL
Sbjct: 292 YQTQSSSPLARLYSSEGSVNERHHLSQAICILNDSSSKILDSLSTEEFKECIDFLRDLIL 351
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATDLA F + ++ L R + + + S++ L +++ +T DLS K W+
Sbjct: 352 ATDLANHFRIMPHLKRL-RPE----NLGEGSNQRLLLSLMITCCDLSDQVKSWKTVQHVA 406
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
+++ EF+ +GD E+ G P MMDR K P Q+ FL+ + P +++L +I P T+
Sbjct: 407 HLVYAEFFAEGDLEKQMGLRPNAMMDRKK-ACIPVLQIEFLTMVVRPTFEILAQIFPETQ 465
Query: 807 PMYAMATKNLNRW 819
N +W
Sbjct: 466 HFLETIDCNRQQW 478
>UniRef50_UPI0000D8B81A Cluster: UPI0000D8B81A related cluster; n=1;
Mus musculus|Rep: UPI0000D8B81A UniRef100 entry - Mus
musculus
Length = 746
Score = 269 bits (660), Expect = 2e-70
Identities = 160/443 (36%), Positives = 237/443 (53%), Gaps = 33/443 (7%)
Query: 409 YSD-YRF-NRDVDEATGYKTISILCMPIKVEGKVI--GVVQMVNKRDDKYFGDDDEAAFE 464
Y D Y F N D+ +G+ S+LC+PI I GV Q++N+ D K F D D+ FE
Sbjct: 304 YKDIYIFQNTRADQISGFHIRSVLCVPIWNSNHQIIAGVAQVLNRLDGKPFDDADQRLFE 363
Query: 465 IFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKE-------- 516
F F GL +++ +YD++ + K VAL+VLSYH TC + EV + K
Sbjct: 364 AFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKVRKRWSCTVSTQ 423
Query: 517 ---------PLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFT 563
PL + A D + D F D + MF +L + +F D TL R+
Sbjct: 424 RERVYAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWL 483
Query: 564 LTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHR 623
LTV+KNYR V YHN+ H + V M+A+L + + + LA+ V CLCHDLDHR
Sbjct: 484 LTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--EILTEVEILAVIVGCLCHDLDHR 541
Query: 624 GYTNKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIR 682
G N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++
Sbjct: 542 GTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 601
Query: 683 HCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSH----RDLAMAISMTAADLSASAKP 738
ILATDL +F + +P H L ++ MTA DL A KP
Sbjct: 602 QSILATDLTLYFDEKILFSRIILQCPLHDGEAEPGHYKQCDPLLRSMLMTACDLGAVTKP 661
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
WEI + +++ EF++QGD+ER+ ++ P + DRN+ +E P Q+ ++ IC+P Y
Sbjct: 662 WEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQA 721
Query: 798 LYRILPNTKPMYAMATKNLNRWK 820
L ++ KPM N +W+
Sbjct: 722 LVKVNAKLKPMLDSVAANRRKWE 744
Score = 110 bits (265), Expect = 1e-22
Identities = 67/154 (43%), Positives = 93/154 (60%), Gaps = 9/154 (5%)
Query: 315 FLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVSTVFDLKF 371
F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS FD+
Sbjct: 4 FFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHA 62
Query: 372 EPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
L E+++P +GI G+V GET+NIPDAY D RFN ++D+ TGYKT S
Sbjct: 63 GTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKS 122
Query: 429 ILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDE 460
+LCMPI+ +G++IGV Q +NK + F +DDE
Sbjct: 123 LLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDDE 156
Score = 39.5 bits (88), Expect = 0.41
Identities = 16/41 (39%), Positives = 29/41 (70%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVD 356
LL+VV +FEE L++++K+I+ AQ L+ +R S+ L++
Sbjct: 185 LLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE 225
>UniRef50_UPI000065DEB3 Cluster: Dual 3',5'-cyclic-AMP and -GMP
phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP
and cGMP phosphodiesterase 11A).; n=1; Takifugu
rubripes|Rep: Dual 3',5'-cyclic-AMP and -GMP
phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP
and cGMP phosphodiesterase 11A). - Takifugu rubripes
Length = 937
Score = 260 bits (637), Expect = 1e-67
Identities = 185/559 (33%), Positives = 285/559 (50%), Gaps = 56/559 (10%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELV--STVFDLKFE- 372
LL+VV +FEE L++++++I++ A L+ +R S+ L++ +S +V S F+L
Sbjct: 379 LLEVVNDLFEEQTDLEKIVRKIMQRALTLLQCERCSVLLLEDIDSPVVKFSKTFELMSPL 438
Query: 373 --PGLDLDMEKKEIR-MPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
D+ MEK IN IA VA +G +NI D D RF+ + D+A+G+ S+
Sbjct: 439 CTMDHDISMEKLSCSDWLINNSIAELVASTGLPVNISDVCQDPRFDAEADQASGFHIRSV 498
Query: 430 LCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFE-------------------IFSTF 469
LC+PI ++IGV Q++N+ D K F D D+ FE F F
Sbjct: 499 LCVPIWNRTHQIIGVAQILNRLDRKTFNDADQRLFEEIHVILKHNCYFLCLFLSQAFVIF 558
Query: 470 FGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFA--DFYL 527
GL +++ +Y+++ + K VAL++LSYH TC + EV + K PL+ + +F+
Sbjct: 559 CGLGINNTMMYNQVKKTWAKQSVALDMLSYHATCSKVEVDRLKAAKIPLSSELGIDEFHF 618
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTVKKNYRTVPYHNFDH--GWT 583
+ F D + MF +L + +F D L R+ LTV+KNYRTV YHN+ H +T
Sbjct: 619 NDFSLDNDAMITASLRMFLELGVVQKFKIDYEVLCRWLLTVRKNYRTVAYHNWRHLQCFT 678
Query: 584 V-AHAMYAILK-------SDVKERFDYN----KASSRLALFVACLCHDLDHRGYTNKY-M 630
V H Y IL D+ R N K S A CH + + + +
Sbjct: 679 VHVHNDYKILALMVGCLCHDLDHRGTNNAFQAKCVSEAWGMTANWCHISEAKKPNSLFPS 738
Query: 631 SETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATD 689
S T S LA +Y TS TLEHHHFN V ILQ +GHNIF+++ S++Y ++ ++ IL+TD
Sbjct: 739 SRTGSALALLYGTSATLEHHHFNHAVMILQSEGHNIFANLCSKEYSNMMQLLKQAILSTD 798
Query: 690 LAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT---- 745
L F K E S E F W D HR++ ++ MTA DL A +PW+I ++
Sbjct: 799 LTLHFERRTKFFESVLSGE--FKWTDEGHREVFRSMLMTACDLGAVTRPWKISKRSGALV 856
Query: 746 -VKVIFEEFYDQGDKERAAGRI---PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRI 801
+++ + GD+ I P P+ DRN+ +E P Q+ ++ IC P Y L ++
Sbjct: 857 GIQISSNSSFWPGDETVCRNLIIFSPQPIFDRNRKDELPDLQLEWIDGICKPLYKTLLKL 916
Query: 802 LPNTKPMYAMATKNLNRWK 820
+PM N N+W+
Sbjct: 917 NRKLQPMVDEMDANRNKWQ 935
Score = 110 bits (265), Expect = 1e-22
Identities = 69/165 (41%), Positives = 99/165 (60%), Gaps = 8/165 (4%)
Query: 303 YVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVD--YRNS 360
Y + +E N +F L++VK I ++ L L +IL LV+ADR SLFLV+
Sbjct: 74 YKYRLKETNEREFFLELVKDISNDL-DLTNLSYKILINVCILVDADRCSLFLVEGPAHKR 132
Query: 361 ELVSTVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRD 417
LVS FD+ + + E+++P +GI G+VA GET+NIP+AY D+RF+ +
Sbjct: 133 TLVSKFFDVHSGTTVRPSSSTLNSNEVQVPWGKGIIGYVAEHGETVNIPNAYEDHRFSDE 192
Query: 418 VDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRD-DKYFGDDDE 460
+D+ TGYKT SILC+ I +G+VIGVVQ +NK F +DDE
Sbjct: 193 IDKLTGYKTQSILCLAICNSDGEVIGVVQAINKNPMGTPFTEDDE 237
>UniRef50_Q4RHZ1 Cluster: Chromosome 8 SCAF15044, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 8 SCAF15044, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 884
Score = 252 bits (618), Expect = 2e-65
Identities = 170/527 (32%), Positives = 274/527 (51%), Gaps = 34/527 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELV--STVFDLKF-- 371
LL+VV +FEE L++++++I++ A L+ +R S+ L++ +S +V S F+L
Sbjct: 367 LLEVVNDLFEEQTDLEKIVRKIMQRALTLLQCERCSVLLLEDIDSPVVKFSKTFELMSPL 426
Query: 372 -EPGLDLDMEKKEIR-MPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
D+ MEK IN IA VA +G +NI D D RF+ + D+A+G+ S+
Sbjct: 427 CNMDRDISMEKLSCSDWLINNSIAELVASTGLPVNISDVCQDPRFDAEADQASGFHIRSV 486
Query: 430 LCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
LC+PI ++IGV Q++N+ D K F D D+ FE F F GL +++ +Y+++ +
Sbjct: 487 LCVPIWNRTHQIIGVAQILNRLDRKTFNDADQRLFEAFVIFCGLGINNTMMYNQVKKTWA 546
Query: 489 KYRVALEVLSYHNTCREYEVQAMLLDKEPLN--VDFADFYLDPFRFDEFEKCKCIISMFR 546
K VAL++LSYH TC + EV + K PL+ + +F+ + F D + MF
Sbjct: 547 KQSVALDMLSYHATCSKVEVDRLKAAKIPLSGELGIEEFHFNDFSLDNDAMITASLRMFL 606
Query: 547 DLFDMTQFDI---------TTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVK 597
+L + +F I L R+ LTV+KNYRTV YHN+ H + V+ M+ ++ +
Sbjct: 607 ELGVVQKFKIDYEVRGQPRKVLCRWLLTVRKNYRTVAYHNWRHAFNVSQCMFIMITTASF 666
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVT 656
+ D + LAL V CLCHDLDHRG N + ++T S LA +Y T++TLEHHHFN V
Sbjct: 667 Q--DVLSDAEVLALMVGCLCHDLDHRGTNNAFQAKTGSALALLYGTSATLEHHHFNHAVM 724
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDP 716
ILQ + + + E+ C L + + ++ EL S+ F D
Sbjct: 725 ILQSE-----VGVDQNELVEVHADDSGCDLGA-VTRPWKISKQVAELVTSE--FFEQGDR 776
Query: 717 SHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI---PMMDR 773
+L + +++ LS +A + + +K + V+ D D P+ P+ DR
Sbjct: 777 ERAELKLTPAVSKKVLSVTA--FAVLLKKIFVVSIGRNDTKDPLDVTKGSPLSLQPIFDR 834
Query: 774 NKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
N+ +E PA Q+ ++ IC P Y L ++ +PM N N+W+
Sbjct: 835 NRKDELPALQLEWIDGICKPLYQTLLKLNRKLQPMADEIDANRNKWQ 881
Score = 126 bits (303), Expect = 4e-27
Identities = 75/197 (38%), Positives = 118/197 (59%), Gaps = 8/197 (4%)
Query: 303 YVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVD--YRNS 360
Y + +E N +F L++VK I ++ L L +IL LV+ADR SLFLV+
Sbjct: 147 YKYRLKETNEREFFLELVKDISNDL-DLTNLSYKILINVCILVDADRCSLFLVEGPAHKR 205
Query: 361 ELVSTVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRD 417
LVS FD+ + + E+++P +GI G+VA GET+NIP+AY D+RF+ +
Sbjct: 206 TLVSKFFDVHSGTTVRPSSSTLNSNEVQVPWGKGIIGYVAEHGETVNIPNAYEDHRFSDE 265
Query: 418 VDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRD-DKYFGDDDEAAFEIFSTFFGLALH 475
+D+ TGYKT SILC+ I +G+VIGVVQ +NK F +DDE +++ F G+++
Sbjct: 266 IDKLTGYKTQSILCLAICNSDGEVIGVVQAINKSPMGTPFTEDDEKVLQMYLPFCGISIS 325
Query: 476 HARLYDRIMRKEQKYRV 492
+A+L+ ++ ++ RV
Sbjct: 326 NAKLFSESRKEYERSRV 342
>UniRef50_P16499 Cluster: Rod cGMP-specific 3',5'-cyclic
phosphodiesterase subunit alpha; n=90; Vertebrata|Rep:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit
alpha - Homo sapiens (Human)
Length = 860
Score = 241 bits (589), Expect = 8e-62
Identities = 148/473 (31%), Positives = 243/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G NI +A ++ + F ++ + +G+ ++L MPI + +++GV
Sbjct: 345 GLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFY 404
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + Y+ + + E + + +++ YH C E
Sbjct: 405 NRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEE 464
Query: 508 VQAML-----LDKEP-----------LNVDFAD---FYLDPFRFD-----EFEKCKCIIS 543
+Q +L KEP L + D + ++ F F E E KC I
Sbjct: 465 IQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQ 524
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ V M+++L + +R
Sbjct: 525 MYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKR-- 582
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y LA+ A CHD+DHRG N Y ++ +PLA ++ +S LE HH T+L+ +
Sbjct: 583 YFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDE 642
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NIF +++ ++ + + I+ATDLA +F KI + ++ E++ W
Sbjct: 643 SLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMM 702
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMMD
Sbjct: 703 LEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMD 762
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK +E P QVGF+ +C Y R PM T N WKA AD+
Sbjct: 763 RNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADE 815
Score = 82.2 bits (194), Expect = 6e-14
Identities = 54/166 (32%), Positives = 88/166 (53%), Gaps = 5/166 (3%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S+ + D+++ F+E + ++ I +++ L+ ADR SLF+ RN +EL + +F++
Sbjct: 58 SEIIFDLLRD-FQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVH 116
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L M +EI P++ GI GHVA S + N+P+ D F VD T YKT +
Sbjct: 117 KDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKN 176
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLAL 474
IL PI V+ ++ VNK D +F DE + F L +
Sbjct: 177 ILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM 222
>UniRef50_Q6S996 Cluster: Class I phosphodiesterase PDEB1; n=21;
Trypanosomatidae|Rep: Class I phosphodiesterase PDEB1 -
Leishmania major
Length = 940
Score = 238 bits (582), Expect = 6e-61
Identities = 169/534 (31%), Positives = 262/534 (49%), Gaps = 44/534 (8%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFE-EMVSLDQLIKRILEF 340
DEE+ ++ + +L C++ +E+ SD +LDVV + ++ +D +++ +L
Sbjct: 374 DEELFETFSMFAAASLRNCRINETLLKEKKKSDAILDVVALLSNTDIRDVDSIVRHVLHG 433
Query: 341 AQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSG 400
A++L+NADR+S+FL+D +EL S + D EIR P +GIAG VA SG
Sbjct: 434 AKKLLNADRSSMFLLDKERNELYSKMAD-----------SANEIRFPCGQGIAGTVAESG 482
Query: 401 ETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDD----KYFG 456
NI DAY+D RFN VD GY+T SILC PI + G+V+ VVQ+VNK D F
Sbjct: 483 VGENIMDAYADSRFNSAVDRQLGYRTQSILCEPITLNGEVLAVVQLVNKLGDDGSVTCFT 542
Query: 457 DDDEAAFEIFSTFFGLALHHARLYDRIM---RKEQKYRVALEVLSYHNTCREYEVQAMLL 513
D F++FS F G++++++ L + + R+ + ++ + +V A+
Sbjct: 543 PMDRETFQVFSLFAGISINNSHLLEFAVNAGREAMTLSLQRNSITAQRAPKSVKVIAVTP 602
Query: 514 DKEP--LNVDFA---DFYLDPFR-FDEFEK--------CKCIISMFRDLFDMTQFDI--T 557
++ +++DF DF F F+ EK + ++ + +F
Sbjct: 603 EEREAVMSIDFGGAYDFTSPGFNLFEVREKYSEPMDAAAGVVYNLLWNSGLPEKFGCREQ 662
Query: 558 TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLC 617
TL F L ++ YR VPYHNF H V ++ L + + + L V L
Sbjct: 663 TLLNFILQCRRRYRRVPYHNFYHVVDVCQTLHTYLYTG--KASELLTELECYVLLVTALV 720
Query: 618 HDLDHRGYTNKYMSETASPL----AAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSED 673
HDLDH G N + +T SPL +A S LE HH ++ + IL ++F +S +D
Sbjct: 721 HDLDHMGVNNSFYLKTDSPLGILSSASGNNSVLEVHHCSLAIEILSDPAADVFEGLSGQD 780
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLS 733
+ C+LATD+A L + EL S F D+ +HR L M + A D+S
Sbjct: 781 VAYAYRALIDCVLATDMAKHADALSRFTELATSG---FEKDNDTHRRLVMETLIKAGDVS 837
Query: 734 ASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
KP+E + EEFY QGD E+ G +PM DR+K E Q+GF+
Sbjct: 838 NVTKPFETSRMWAMAVTEEFYRQGDMEKEKGVEVLPMFDRSKNNELARGQIGFI 891
Score = 119 bits (287), Expect = 3e-25
Identities = 79/247 (31%), Positives = 129/247 (52%), Gaps = 28/247 (11%)
Query: 306 KKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVST 365
+KRE N + ++ + + + + L++ I+ A+ L +DR S+FLV S
Sbjct: 225 RKREANKIEAMVGMATRLARDTLEESVLVQSIINTAKTLTESDRCSIFLVKADGS----- 279
Query: 366 VFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYK 425
+ FE G + +P GIAGHVA SG +NIP+AY D RF+R VD+ TGY
Sbjct: 280 -LEAHFEDG-------NVVVLPAGTGIAGHVAESGAVVNIPNAYEDDRFHRSVDKVTGYH 331
Query: 426 TISILCMPIKVEGKVIGVVQMVNKRD---------DKYFGDDDEAAFEIFSTFFGLALHH 476
T +ILC+PI EG ++ V Q++NK D + FG DE FE FS F +L +
Sbjct: 332 TRTILCLPIAFEGTIVAVAQLINKLDMVTQSGQRLPRVFGRRDEELFETFSMFAAASLRN 391
Query: 477 ARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLD-----KEPLNVDFAD-FYLDPF 530
R+ + ++++++K L+V++ + +V +++ K+ LN D + F LD
Sbjct: 392 CRINETLLKEKKKSDAILDVVALLSNTDIRDVDSIVRHVLHGAKKLLNADRSSMFLLDKE 451
Query: 531 RFDEFEK 537
R + + K
Sbjct: 452 RNELYSK 458
>UniRef50_UPI0000F1D4E2 Cluster: PREDICTED: similar to
Phosphodiesterase 5A; n=4; Danio rerio|Rep: PREDICTED:
similar to Phosphodiesterase 5A - Danio rerio
Length = 905
Score = 226 bits (552), Expect = 2e-57
Identities = 163/558 (29%), Positives = 269/558 (48%), Gaps = 39/558 (6%)
Query: 278 FKVIDEEI-SGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKR 336
F DE++ S H++++G + ++ +L ++E + LL++ + + + S+D ++
Sbjct: 364 FSEQDEKVLSSHMMLFGLILENH-QLCESSEQENKRNQVLLELAQLVSHDYPSVDAMLGE 422
Query: 337 ILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEP-GLDLDMEKKEIRMP-INRGIAG 394
+ + A ++F+ D ++ L S + +++E + ++ ++ A
Sbjct: 423 LAAVILPITKAQFCTVFISDDSSTRLFSRMVRIEYEEIECSVHCSSRDCDTDDVSYIYAM 482
Query: 395 HVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKR---- 450
HV S ET+NI NR + + +++ + K VIGV Q+VNKR
Sbjct: 483 HVQNSMETLNI--------VNRPISMVSPIRSLIGAPLRGKQSSNVIGVCQLVNKRMAIA 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
+ + F DE E F+ + L L + K RV L V + +A
Sbjct: 535 ESEAFSRADEHLLEDFAVYCALGLQKFNT----QQTADKTRVRLAVT---------KEEA 581
Query: 511 MLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTVKK 568
+ + L++ DF F + + ++ MF DL +F D L ++ L+V+K
Sbjct: 582 AIPSADTLSL--LDFGFSDFDMSQNAMTQAVVRMFLDLNLPQEFKIDYKALCQWVLSVQK 639
Query: 569 NYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTN 627
YR+ V YHN+ H A M+A+L++ KE + LAL +A L HDLDHRG N
Sbjct: 640 CYRSNVVYHNWSHALRTAQCMFAMLQT--KELKSNLSSLEVLALMIASLSHDLDHRGVNN 697
Query: 628 KYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILA 687
Y+ + PLA +Y S+LEHHH+++ + IL G I S +S +Y L I ILA
Sbjct: 698 SYIQRSNQPLAQLYGQSSLEHHHYDMCLLILNNPGSQILSSLSVNEYMACLQMIEKNILA 757
Query: 688 TDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVK 747
TDLA FF K +L ++ W D HR+L ++ MTA+D+ A KPW +Q + +
Sbjct: 758 TDLAIFFEKRTKFFKLAENNSC--LWKDEGHRELLRSMLMTASDICAITKPWPVQKRIAE 815
Query: 748 VIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
++ EFY QGD+E+ I PI +MDR P QV ++ IC P Y+ L I +
Sbjct: 816 LVATEFYAQGDREKRELNIQPIDVMDRENASRLPQMQVDYIDGICSPLYEALAFICESCS 875
Query: 807 PMYAMATKNLNRWKARAD 824
P+ +KN W+ D
Sbjct: 876 PLKEGCSKNRKHWQEMVD 893
Score = 53.2 bits (122), Expect = 3e-05
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
D D + N+ I +V +G + + DA+ D RF ++ E + S+L +P+
Sbjct: 281 DADSVHSNAQTKWNKSIMEYVVRTGRPLTVKDAHEDPRFQVELYEGEEDRPTSVLSVPVL 340
Query: 436 VEGK-VIGVVQMVNKR---DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYR 491
K VIGVV VNK +F + DE FGL L + +L + ++ ++ +
Sbjct: 341 NHKKEVIGVVLAVNKTRTCASSFFSEQDEKVLSSHMMLFGLILENHQLCESSEQENKRNQ 400
Query: 492 VALEV 496
V LE+
Sbjct: 401 VLLEL 405
>UniRef50_A2DYU6 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1091
Score = 223 bits (546), Expect = 1e-56
Identities = 164/581 (28%), Positives = 275/581 (47%), Gaps = 27/581 (4%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
IL PI + V EM D F D + V+ ++L LY + + +
Sbjct: 506 ILSVPIYNNRTEIIGVTEMINKNDNKPFTQWDINVIQIFNVFAGISLENVFLYKEAQEKG 565
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
LLDV +I + + +L+K IL A++ +NA+ +SLFL+D + L S + D
Sbjct: 566 EQLRSLLDVSFSITKRE-DVQRLLKDILSNARKQINAECSSLFLLDETSDSLTSYIADGG 624
Query: 371 FEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISIL 430
P +P++ GI + A S + + D Y FNR VD +TG+KT S+L
Sbjct: 625 TLPP----------NLPLSSGIVAYCAKSKKGIINNDVYHSPEFNRTVDISTGFKTNSLL 674
Query: 431 CMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
+P+ G++IGVV+MVNK D+ F + D + F+ +A+ + RL
Sbjct: 675 AVPVLSGSGELIGVVEMVNKVDN-CFNNKDLEIVQNFAVLSSVAIENDRLKGIATNGSAD 733
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFA-DFYLDPFR-FDEFEKCKCIISMFRD 547
++ + T + + L +E V + +F+ FR + + + S F
Sbjct: 734 VEMSKWITEPERTLTDQIPAKLKLTEEQQKVASSLNFFSPDFRGINHIRELFYLFSKFNI 793
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVA-HAMYAILKSDVKERFDYNKAS 606
L D + RF ++ Y VPYHN+ H V + Y + S E
Sbjct: 794 LRDF-KISNELFFRFIYKIRSTYNDVPYHNWMHACDVTEYVAYELKTSGFDEMLS---PL 849
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNI 665
+ AL ++ +CHD +H G+ N + + +PL ++ TS +E HH +++ IL D +N+
Sbjct: 850 EKFALLLSAVCHDANHEGFNNIFNIKAQTPLGLLFKDTSVMETHHLTVSIDILSDDSYNL 909
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
+S ED K++ + ILATD+A F + + L D +F + HR +AM++
Sbjct: 910 IYSLSEEDTKKMWQMMIQNILATDMAKHFEMIKTTKALV--DAGEFDLNKEEHRRIAMSL 967
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQV 784
+ AD+S ++P+E+ ++ EFY QGD E+A G + P+ DR P ++P SQ+
Sbjct: 968 LLKVADISNVSRPFELADNWCDILNVEFYRQGDLEKATGIGLTSPLNDREHP-DKPKSQI 1026
Query: 785 GFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
GF + +C+P Y+++ I P + NL W A+K
Sbjct: 1027 GFYNFVCLPLYNVVATIFPKLQVNADSVKSNLAVWMELAEK 1067
Score = 116 bits (280), Expect = 2e-24
Identities = 76/207 (36%), Positives = 117/207 (56%), Gaps = 14/207 (6%)
Query: 309 ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFD 368
ER LL+V + + + D+L+ I+E ++L NADR +LF+V+ +L+++
Sbjct: 397 ERESLGALLEVAELLGNQR-DKDKLLLTIMEKGRQLTNADRCALFIVNDDKDKLITS--- 452
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
F+ GL+ I +PIN+GIAGH MNI DAY + F+ D+ TGY+T S
Sbjct: 453 --FQNGLE-----NAITIPINKGIAGHTYAERTIMNITDAYENQYFDPTTDKETGYRTRS 505
Query: 429 ILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKE 487
IL +PI ++IGV +M+NK D+K F D +IF+ F G++L + LY K
Sbjct: 506 ILSVPIYNNRTEIIGVTEMINKNDNKPFTQWDINVIQIFNVFAGISLENVFLYKEAQEKG 565
Query: 488 QKYRVALEVLSYHNTCREYEVQAMLLD 514
++ R L+V S+ T RE +VQ +L D
Sbjct: 566 EQLRSLLDV-SFSITKRE-DVQRLLKD 590
>UniRef50_A2FBN7 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1090
Score = 222 bits (542), Expect = 4e-56
Identities = 163/580 (28%), Positives = 277/580 (47%), Gaps = 29/580 (5%)
Query: 251 NYILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCKLYVDKKR 308
N +L PI + G+ V EM D F D ++ V+ +++ KLY +
Sbjct: 516 NTLLCVPIFNQKGEVIGVTEMVNKLDGKPFSEWDAKVIQIFNVFCGISIQNAKLYKESVD 575
Query: 309 ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFD 368
DV A+ + + +++++I+ ++ A+RAS+FL D N L + D
Sbjct: 576 METQLQSFFDVSVAV-SKSEDMKEVLQQIIARSRDAAEAERASIFLFDPANDCLKVFLAD 634
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
P +P+N GIA + D Y D RFNR VD A+G+KT +
Sbjct: 635 GTNVPET----------LPMNTGIAAQCVKLRRAIVANDVYHDPRFNRSVDTASGFKTNN 684
Query: 429 ILCMPIKVE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKE 487
++ +P+ G ++GVV+M NK+D F D D + F++F + L L + E
Sbjct: 685 LVVVPLLTPGGDILGVVEMCNKKDGD-FDDHDAKLVQSFASFVEMTLEKFELKNIASLGE 743
Query: 488 QKYRVALEV-LSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFR 546
+ + + S +C E ++ L +++ N+ +F ++ ++ K II F
Sbjct: 744 TEIEMLKWIGESERESCTEIPLRLRLKEEQIQNLRQLNFM--ALDWEPMDRIKSIIYQFY 801
Query: 547 DLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGW-TVAHAMYAILKSDVKERFDYN 603
+F I+ L RF V + Y + PYHN+ H V + Y + +++ F
Sbjct: 802 SFGIPQEFRISNQMLFRFIWEVMRTYHSTPYHNWIHAVDVVQYVSYEMRLGELENIFTKF 861
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDG 662
+ A+ VA +CHD H G+ N Y + +PL ++ S +E +H + ++IL +
Sbjct: 862 EI---FAMLVAAVCHDAGHSGFNNIYNVKAETPLGILFKEQSVMETYHCTVAISILTRKE 918
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
N+F I+ E K++ I ILATD+A F + E D F+ +DP R +A
Sbjct: 919 CNLFHSITEEAQKQMWTLIIKLILATDMAFHFKMVKAATEF--MDAGPFNPNDPEQRLIA 976
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERA-AGRIPIPMMDRNKPEEQPA 781
+ + AD+S ++P+++ K V+ EEF+ QGDKE+A A + P+ DR+ P ++P
Sbjct: 977 FQLVLKTADISNVSRPFKVADKWCDVLCEEFFRQGDKEKAQAFGLTSPLNDRDNP-DKPK 1035
Query: 782 SQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKA 821
SQ+GF + +CIP Y ++ RI P + NL WK+
Sbjct: 1036 SQIGFYNFVCIPLYSVISRIFPKFEVNLNSVKSNLEVWKS 1075
Score = 116 bits (279), Expect = 3e-24
Identities = 91/309 (29%), Positives = 152/309 (49%), Gaps = 26/309 (8%)
Query: 237 LSLLRSCNSRN---KQGNYILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVV 291
L+ L SC + K +L P+I Y + + K F DE++ I
Sbjct: 325 LNKLHSCYNMEFDFKNDEAVLVVPVIQSQVNYDYAVCIRGPKANSIFTRYDEDLLKKIAP 384
Query: 292 WGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFE--EMVS----LDQLIKRILEFAQRLV 345
+ ++A L+ + + S F D + A+ E E++S +D+L + I+E + L
Sbjct: 385 YIALAFSNSTLHSEFFNDFQNSKFEQDGLAALLEVAEVLSSQLDIDKLTETIMEKGRTLT 444
Query: 346 NADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNI 405
NADR SLFL++ L+++ F+ GLD ++ +PI RG G + +NI
Sbjct: 445 NADRCSLFLINETGERLITS-----FQHGLDTAID-----LPIRRGAVGLAVKEQKVVNI 494
Query: 406 PDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFE 464
DAY D F+R D +GY T ++LC+PI +G+VIGV +MVNK D K F + D +
Sbjct: 495 ADAYQDPNFDRSTDIESGYHTNTLLCVPIFNQKGEVIGVTEMVNKLDGKPFSEWDAKVIQ 554
Query: 465 IFSTFFGLALHHARLYDRIMRKEQKYRVALEV---LSYHNTCREYEVQAMLLDKEPLNVD 521
IF+ F G+++ +A+LY + E + + +V +S +E Q + ++ +
Sbjct: 555 IFNVFCGISIQNAKLYKESVDMETQLQSFFDVSVAVSKSEDMKEVLQQIIARSRDAAEAE 614
Query: 522 FADFYL-DP 529
A +L DP
Sbjct: 615 RASIFLFDP 623
>UniRef50_P30645 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-2; n=5; Eumetazoa|Rep: Probable 3',5'-cyclic
phosphodiesterase pde-2 - Caenorhabditis elegans
Length = 859
Score = 217 bits (530), Expect = 1e-54
Identities = 159/511 (31%), Positives = 245/511 (47%), Gaps = 30/511 (5%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPI 388
+L LI I+ A++ A+ ++FL D N ++V + G DM
Sbjct: 177 NLSALISCIIAEAKKNTEAEDYAVFLHDEDNKQMVLFNNETMLMTGKKFDM--------- 227
Query: 389 NRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP-IKVEGKVIGVVQMV 447
GI G VA + TMNI D FN ++DE K +++ P I +IGV+ +
Sbjct: 228 GYGIVGKVASTMRTMNIRDVSRCPFFNEEIDEQFSIKARNLIAFPLIDSSCSLIGVIVLY 287
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
NK + F DE + FS F ++ HA L +I + + E E
Sbjct: 288 NKENG--FSRHDEKYIKRFSYFVANSIAHAILAKQIEEVRTRIHMVEEFKIQGEDAVIEE 345
Query: 508 VQAMLLDKEPL------NVDFADFYLDPFRFDEFEKCKCIISMFRDL-FDMT-QFDITTL 559
V M L +PL + +FADF P E + + F DL F M + + L
Sbjct: 346 VDIMRLVNDPLRDWRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKL 405
Query: 560 TRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHD 619
+ L V YR VPYHN+ H + V H + L++D R + RL+L +ACLCHD
Sbjct: 406 SYLVLRVSAGYRPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDM--ERLSLLIACLCHD 463
Query: 620 LDHRGYTNKYMSETA--SPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYK 675
+DHRG TN + ++ +PL+ +Y+T S LE HHF T+ +LQQ+ +I ++ + D++
Sbjct: 464 IDHRGTTNSFQMQSLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQEECSILENLPAADFR 523
Query: 676 EILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSAS 735
I+ IR ILATD++A ++I+ + S+D HR L M + MTA+DLS
Sbjct: 524 TIVNTIREVILATDISAHLRKQERIKTMISEGYNPMSFD---HRYLLMCLVMTASDLSDQ 580
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
AK + + + I+ EF+ QGD E G P+ MMDR P Q+ FL +I +P +
Sbjct: 581 AKNFHNAKRIAENIYLEFFAQGDLELQLGVKPLEMMDRTN-AYVPTVQIDFLFKIGVPVF 639
Query: 796 DMLYRILPNTKPMYAMATKNLNRWKARADKI 826
+L ++P + N W A +++
Sbjct: 640 QLLASVVPEGRTTSEAIDANHLCWVALDEEV 670
>UniRef50_A2D762 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1081
Score = 213 bits (520), Expect = 2e-53
Identities = 152/575 (26%), Positives = 267/575 (46%), Gaps = 21/575 (3%)
Query: 253 ILYQPIITKSGKTSYVLEMW-RTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERN 311
IL PII + V EM + +F D + V+ ++L +LY D
Sbjct: 518 ILSVPIINNRSEVIGVTEMVNKINGKFTEWDAHMIKIFNVFCGISLENARLYQDSVEMSQ 577
Query: 312 MSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKF 371
DV ++ S+ +++ I++ A+ + A+ ASL ++D + L S + D
Sbjct: 578 QLHSFFDVSFSL-SNSESIQRILGDIIKNARNTIGAECASLLILDEPLNCLQSFLVDGGT 636
Query: 372 EPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILC 431
P ++P+ G+A S E + + Y D RFNR +D +KT +L
Sbjct: 637 IPS----------QLPLTTGLAAAAIKSREVIVSNNCYDDPRFNRTIDIENNFKTERLLV 686
Query: 432 MPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKY 490
PI +G V+G V+MVNK++ F DDD + F+ F ++L + RL +
Sbjct: 687 APIISQKGVVLGAVEMVNKKNGD-FDDDDCKLLKSFAAFAAVSLENQRLKSIADLGTSEA 745
Query: 491 RVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFD 550
+ + + + + L D++ V +F+ ++ K I +L +
Sbjct: 746 ELPKYISESEKSSSKTPSKLQLTDEQKKLVSSLNFFSPDYKGVGHIKILFFIFQKFNLLE 805
Query: 551 MTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLA 610
+ RF +++ Y VPYHN+ H V Y + E K LA
Sbjct: 806 EFKIPNDMFFRFIFAIREKYNEVPYHNWMH--CVDVCQYLAYEVSTAELDKVYKPLELLA 863
Query: 611 LFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHI 669
+FVA +CHD H G N Y + +PL ++ S +E HH + +++L ++ +N+F +
Sbjct: 864 MFVAAVCHDAGHEGLNNIYNVKAETPLGILFKDQSVMETHHCTVAISLLTKEEYNLFHSV 923
Query: 670 SSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTA 729
E +++ I ILATD+A F + E+ +D+A+F + P HR L+M + +
Sbjct: 924 DLEHQRQLWTTIIQLILATDMANHFKLVKDTNEI--ADKAEFDIEKPEHRLLSMKLLLKV 981
Query: 730 ADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVGFLS 788
D+S ++P++I K ++ EEF+ QGD E++ G + P+ DR ++P SQ+GF +
Sbjct: 982 GDISNVSRPFQIADKWCDILCEEFFRQGDNEKSLGIGLTSPLNDRLN-NDKPKSQIGFYN 1040
Query: 789 QICIPCYDMLYRILPNTKPMYAMATKNLNRWKARA 823
+C+P Y ++ ++ P + + NL WK A
Sbjct: 1041 FVCLPLYQVVAKLFPPLEVNHQSVKNNLEVWKELA 1075
Score = 97.1 bits (231), Expect = 2e-18
Identities = 79/253 (31%), Positives = 124/253 (49%), Gaps = 20/253 (7%)
Query: 253 ILYQPIITKSGKTSY--VLEMWRTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
IL P+ +G Y VL RT F+ D + + V+ S ++ + E
Sbjct: 344 ILINPVRESTGAFVYLYVLRGPRTATVFRSSDVVVFQKMTVFSSFSISNADKFTSMNEEL 403
Query: 311 NMSDFLLDVVKAIFE--EMVS----LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
S + A+ E E++S + +L + I+E + L +DR SLFLV+ + L++
Sbjct: 404 IQSSDRSQGLSALLEVAEVLSRQLDIGKLTEAIMEKGRSLTKSDRCSLFLVNEKRDRLIT 463
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
+ F+ GL I +PI++GIAG T I DAY+D F+ D TGY
Sbjct: 464 S-----FQHGLS-----NAIVIPIDKGIAGRTVREKTTAFIEDAYADPDFDSSTDLETGY 513
Query: 425 KTISILCMP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
+T +IL +P I +VIGV +MVNK + K F + D +IF+ F G++L +ARLY
Sbjct: 514 RTKNILSVPIINNRSEVIGVTEMVNKINGK-FTEWDAHMIKIFNVFCGISLENARLYQDS 572
Query: 484 MRKEQKYRVALEV 496
+ Q+ +V
Sbjct: 573 VEMSQQLHSFFDV 585
>UniRef50_Q4RNP2 Cluster: Chromosome 2 SCAF15010, whole genome
shotgun sequence; n=58; Fungi/Metazoa group|Rep:
Chromosome 2 SCAF15010, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1093
Score = 204 bits (497), Expect = 1e-50
Identities = 160/502 (31%), Positives = 237/502 (47%), Gaps = 59/502 (11%)
Query: 300 CKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVD--- 356
C+ + RE+ LL+VV +FEE L++++++I+ AQ L+ +R S+ L++
Sbjct: 456 CQTLIADGREQLEPTALLEVVNDLFEEQTDLEKIVRKIMHRAQTLLKCERCSVQLLEDIE 515
Query: 357 ------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRGIAGHVALSGETMNIPDAY 409
++ EL+S + MEK IN IA VA +G +NI DAY
Sbjct: 516 SPVVKFTKSFELLSPKCSADADSSFKDSMEKSSYSDWLINNSIAELVASTGLPVNISDAY 575
Query: 410 SDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEI--- 465
D RF+ + D+ + + S+LC+PI ++IGV Q++N+ D K F D D+ FE+
Sbjct: 576 QDPRFDAEADQFSDFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEVFLF 635
Query: 466 -----------------------FSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNT 502
F F GL +++ +YD++ + K VAL+VLSYH T
Sbjct: 636 DSAWAPRLRRRLANGCLLVSSQAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHAT 695
Query: 503 CREYEVQAMLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITT 558
C + EV PL + D F D + MF +L + +F D T
Sbjct: 696 CSKTEVDKFKAANIPLVCELGIDKLSFDDFSLDVDAMITAALRMFIELGMVQKFKIDYET 755
Query: 559 LTRFTLTVKKNYRT-VPYHNFDHGWT-----VAHAMYAILKSDVKERFD----YNKASSR 608
L R+ LT +K R V YHN+ H V A L D D R
Sbjct: 756 LCRWLLTCQKKLRDMVLYHNWRHSLQRLPVHVCDAHDGRLPGDPDGCGDPGAHRGMCVPR 815
Query: 609 LALFVACLCHDLDHRGYTNKYMSE-----TASPLAAMYTTS-TLEHHHFNITVTILQQDG 662
L C H + E T S L+ +Y TS TLEHHHFN V ILQ +G
Sbjct: 816 LGPQGHQQCFPGQHLQQSAALQRESNGKWTGSALSLLYGTSATLEHHHFNHAVMILQSEG 875
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
HNIF ++SS +Y +++ ++ ILATDL +F N + EL + E ++W+ +HRD+
Sbjct: 876 HNIFCNLSSTEYSDLMQLLKQSILATDLTLYFENRNNFFELVSNGE--YNWNVKTHRDMC 933
Query: 723 MAISMTAADLSASAKPWEIQIK 744
++ MTA DL A KPW+I K
Sbjct: 934 RSMMMTACDLGAVTKPWDISRK 955
Score = 124 bits (298), Expect = 1e-26
Identities = 69/157 (43%), Positives = 101/157 (64%), Gaps = 5/157 (3%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE--LVST 365
+E N +F L++VK I ++ L L +IL F +V+ADR SLFLV+ ++ LVS
Sbjct: 159 KEHNEREFFLELVKDISNDL-DLTSLSYKILVFVCIMVDADRCSLFLVEGTGNKKTLVSK 217
Query: 366 VFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYK 425
FD+ + M E+++P +GI G+VA GET+NIPDAY D RF+ ++D+ TGYK
Sbjct: 218 FFDVHAGTTVLPSMNSDEVQVPWGKGIIGYVAEHGETVNIPDAYQDRRFSDEIDKLTGYK 277
Query: 426 TISILCMPIK-VEGKVIGVVQMVNKRD-DKYFGDDDE 460
T S+LCMPI+ +G++IGV Q +NK + F +DDE
Sbjct: 278 TKSLLCMPIRNSDGEIIGVAQAINKSSAGQLFTEDDE 314
Score = 48.8 bits (111), Expect = 7e-04
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 766 IPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+P + DRN+ +E P Q+G++ IC P Y+ L ++ P +PM M N +W+
Sbjct: 1022 LPQAIFDRNRKDELPGLQLGWIDGICTPLYETLVKLNPKLQPMVDMIKANRAKWE 1076
>UniRef50_A2G2M9 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1136
Score = 203 bits (496), Expect = 2e-50
Identities = 157/576 (27%), Positives = 271/576 (47%), Gaps = 30/576 (5%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCKLY-VDKKRE 309
+L P++ + VL+M KD F D + + L ++Y V
Sbjct: 543 LLSVPVMNNRLEVIAVLQMINRKDGQPFSQTDFNYMKIFSIMFGLLLDNQQMYSVSTSAN 602
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
R +S F+ V ++ Q++ IL+ A+ +NA+R+SLFL+D +V+T+
Sbjct: 603 RQLSSFIS--VSTALSSNQNVKQILSEILQNARVTINAERSSLFLLD----NVVNTLTSY 656
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
+ G K +P++ GIA ++ I DAY D RFN+ +D TG+KT S+
Sbjct: 657 LVDGG------KMPQSIPLSHGIAATAVKQKISIVIQDAYHDPRFNKMIDFHTGFKTKSL 710
Query: 430 LCMP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
+ +P I +G VIGV +M+NK++ F D+ E FSTF L L RL D +
Sbjct: 711 IAVPVITSDGTVIGVAEMLNKQEG-IFTQSDQTLLESFSTFAALLLEKRRLKDITEKGTA 769
Query: 489 KYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDL 548
+ ++ + + + + + + + + DF+ ++ + +F D
Sbjct: 770 QIEMSKWIGEFERSTYTTPTKLRVPEAKQDVLKSLDFF--AIDWNGIGLFQIAFFVFNDF 827
Query: 549 FDMTQFDITTLTRFTL--TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
+ +F IT FT +++ Y PYHN+ H V Y + +
Sbjct: 828 GLLERFQITNDLFFTFLYRLREAYNEPPYHNWIHAIDV--LQYISYQVRITNSHKILTQF 885
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNI 665
LA+ VA LCHD H+G N + +PL ++ S +E H + + IL Q N+
Sbjct: 886 ELLAVCVAALCHDAGHQGLNNAFNVNAETPLGILFKDQSVMETFHCTVAIRILSQPETNL 945
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
F +++++ I +I H ILATD+A F + + E + + + +HR + M +
Sbjct: 946 FHSLNTKELTVIWKWIIHLILATDMAFHFKLIKQGNEAL--EAGVINLKEEAHRLMCMEL 1003
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI--PMMDRNKPEEQPASQ 783
M +D+S ++P++ K +V+ EEF+ QGDKE+ G +P P+M+R + + +P Q
Sbjct: 1004 VMKVSDISNVSRPFKYADKWCEVLSEEFWRQGDKEKELG-LPYSGPLMNR-EGQNKPKGQ 1061
Query: 784 VGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
VGF + +C+P Y ++ RI P NL +W
Sbjct: 1062 VGFYNFVCLPLYTLIARIFPELTVNLESVKSNLAQW 1097
Score = 75.8 bits (178), Expect = 5e-12
Identities = 57/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 278 FKVIDEEISGHIVVWGSVALH----YCKLYVDKKRE--RNMSDFLLDVVKAIFEEMVSLD 331
F DEE+ G + + +++L Y + RE + F L + ++ E
Sbjct: 395 FTSADEELLGLMTPYLALSLENADKYSSALLGNARESLEHHCVFGLQKIASLINEAAETK 454
Query: 332 QLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRG 391
++ LE ++L +ADR LF D V + + +P + + G
Sbjct: 455 VILNEALENIEKLTSADRVLLFQYDKDTDNYVVSAYIGSKDPPNPISKD---------HG 505
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKR 450
I G S E +N+ +AY D F+ +D T YKT ++L +P+ +VI V+QM+N++
Sbjct: 506 IVGKTFNSKEIINLTEAYEDPNFDNAIDLQTQYKTKTLLSVPVMNNRLEVIAVLQMINRK 565
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
D + F D +IFS FGL L + ++Y
Sbjct: 566 DGQPFSQTDFNYMKIFSIMFGLLLDNQQMY 595
>UniRef50_A2E8N2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1103
Score = 202 bits (494), Expect = 3e-50
Identities = 147/534 (27%), Positives = 261/534 (48%), Gaps = 30/534 (5%)
Query: 295 VALHYCKLYVDKKRERNMSDFLLDVVKAIFE--EMVSLDQLIKRILEFAQRLVNADRASL 352
+++ KL+ K + S L VV+ F + L LI I++ A+ + ADRA +
Sbjct: 551 ISIENAKLF---KESLDNSKRLRAVVECAFSLSKTDKLTLLISDIMKLARLSIGADRAGV 607
Query: 353 FLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDY 412
F++D + L S +++ G D K+I +PI+ G+A + E + D
Sbjct: 608 FVLDEKADMLKSILYE-----GTD-----KQILLPIDNGLAASCCKAKEGAISNNVQLDP 657
Query: 413 RFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG 471
R++ +++ G + ++L P+ +GKV+GV +M+NK F D + F++F
Sbjct: 658 RYDDTLNQQLGIRVTNLLVYPVLSNKGKVLGVAEMINKPSG--FSKADLNLLQFFTSFTA 715
Query: 472 LALHHARLYDRIMRKEQKYRVALEVLSYH-NTCREYEVQAMLLDKEPLNVDFADFYLDPF 530
+AL + + ++ E + + ++ E+ L+ E + +
Sbjct: 716 MALQNQNVSAKLAADAGSTLSTEEENALNPEEEKKCEIPERLVLPEQIQQKLTLREVFQP 775
Query: 531 RFDEFEKCKCIISMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAM 588
F E E+ + F+ M +F+IT L RF +T+++ Y +PYHN+ H V M
Sbjct: 776 DFSEDERVAELFYFFQHFDLMKKFNITAGLLYRFIMTIRETYNVIPYHNWTHAVDVTQFM 835
Query: 589 -YAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTL 646
Y + K+++ + F LA+ VA +CHD +H G+ N+Y + PL ++ S L
Sbjct: 836 VYQLEKAELSKVF---SPFEILAILVATICHDANHNGFNNQYNEKAQLPLGILFKDMSVL 892
Query: 647 EHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS 706
E +H + + I+ ++ NIF+ I ED I I H I ATD+ F + K +EL
Sbjct: 893 EVYHCTVAIGIISKEKTNIFTGIPEEDIPRIWTIIIHMIKATDMKLHFSIVQKAQELL-- 950
Query: 707 DEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-R 765
D +F +DP+ R L+M + + +D+S ++P++ K ++ EEF+ QGD E+ G
Sbjct: 951 DSGKFDMNDPACRLLSMQLLLKVSDISNVSRPFDFANKWCDILNEEFFRQGDNEKKLGLG 1010
Query: 766 IPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
+ P+ DR ++P Q+GF + IC+P Y+++ RI P + NL W
Sbjct: 1011 LSSPLNDREN-ADKPKGQIGFYNFICLPLYNVVKRIFPALSVNADSVSDNLKVW 1063
Score = 99 bits (238), Expect = 3e-19
Identities = 63/190 (33%), Positives = 104/190 (54%), Gaps = 13/190 (6%)
Query: 307 KRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTV 366
+ ER +L V+ + +E+ + ++L I+E A+ L ++DR SLFL++ L++T+
Sbjct: 397 RMEREGLTTILSAVQEVSKEL-NTEKLSDIIVEKARMLTHSDRCSLFLMNDTKDRLITTI 455
Query: 367 FDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
+ GLD I + + RGI G G T+ I DAY++ F+ D+ TGYKT
Sbjct: 456 -----QTGLD-----NYIDISVTRGIVGRTVKDGTTLIINDAYNNEYFDPTTDKETGYKT 505
Query: 427 ISILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
+IL PIK G+ IGV QMVNK Y +D E+F+ F G+++ +A+L+ +
Sbjct: 506 ETILSAPIKNTAGEPIGVTQMVNKYGGNY-TQNDARVIEVFNAFCGISIENAKLFKESLD 564
Query: 486 KEQKYRVALE 495
++ R +E
Sbjct: 565 NSKRLRAVVE 574
>UniRef50_Q4RG61 Cluster: Chromosome 2 SCAF15106, whole genome
shotgun sequence; n=3; Tetraodontidae|Rep: Chromosome 2
SCAF15106, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 899
Score = 180 bits (438), Expect = 2e-43
Identities = 89/253 (35%), Positives = 144/253 (56%), Gaps = 12/253 (4%)
Query: 556 ITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVAC 615
+ TLTR+ TV+K YR + YHN+ HG+ V H M+ +L++ ++ Y+ + A+ A
Sbjct: 587 LQTLTRWMYTVRKGYRAITYHNWRHGFNVGHTMFCLLQTGRLRKY-YSDLDA-FAMVAAA 644
Query: 616 LCHDLDHRGYTNKYMSE-TASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDY 674
CHD+DHRG N Y ++ +A PLA ++ TS +E HH + T++ ++ NIF ++ +
Sbjct: 645 FCHDIDHRGTNNLYQTKRSAHPLAKLHGTSIMERHHLEYSKTLMAEETLNIFCNLQKRQF 704
Query: 675 KEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ--------FSWDDPSHRDLAMAIS 726
+ + CI+ATDLA +F + + + E + ++P +++ MA+
Sbjct: 705 EHVQHLFDVCIIATDLALYFKKRTMFQNIVNATEPMADEKEAIGYVSNNPIRKEIVMAMM 764
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKER-AAGRIPIPMMDRNKPEEQPASQVG 785
MT DLSA KPWE+Q K ++ EF++QGD ER + PIPMMDRN E+ P Q G
Sbjct: 765 MTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLERNVLDQQPIPMMDRNCAEQLPKMQCG 824
Query: 786 FLSQICIPCYDML 798
F+ +C Y ++
Sbjct: 825 FIDFVCSFVYKVM 837
Score = 69.3 bits (162), Expect = 4e-10
Identities = 36/137 (26%), Positives = 73/137 (53%), Gaps = 3/137 (2%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ + +D + F ++ + TG+ ++L +PI + +++G+
Sbjct: 375 GLPSYVAENGFICNMMNVAADDFFTFQKEAVDETGFVIKNVLSLPIVNKKEEIVGIATFF 434
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ R E + +A E+L Y C + E
Sbjct: 435 NRKDGKPFDEHDEQITEALTQFLGWSVLNCDTYDKLNRMEYRKDIAQEMLMYQTRCTKDE 494
Query: 508 VQAMLLDKEPLNVDFAD 524
+Q +L K+ + + D
Sbjct: 495 MQTILNTKDKFDAEPED 511
Score = 44.8 bits (101), Expect = 0.011
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 8/85 (9%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNS--ELVSTVFDL----KFEPGLDLDMEKK 382
+++Q + ++L+ ++ ADR S + RN EL + +FD+ KFE +L +
Sbjct: 71 NMEQCLHKVLQRVALIIQADRLSYYQCRGRNGTPELATCLFDVTPTSKFEA--NLVHPQT 128
Query: 383 EIRMPINRGIAGHVALSGETMNIPD 407
EI P+ GI GH A S + NIPD
Sbjct: 129 EIVFPLEIGIVGHTAQSKKAQNIPD 153
Score = 44.4 bits (100), Expect = 0.014
Identities = 37/148 (25%), Positives = 66/148 (44%), Gaps = 23/148 (15%)
Query: 413 RFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG- 471
+F+ VD+ TGYKT +L P+ E + IGVV +NK F +DE F + F
Sbjct: 188 KFSDFVDKQTGYKTKCMLTYPMVAEKECIGVVMALNKIGAPAFTAEDEQLFHKYMNFAQV 247
Query: 472 LALHH--------------------ARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAM 511
+ L H +++++ + E+++ AL + + C Y V +
Sbjct: 248 ITLQHYTAYMFNVESRRSQVLLWSASKVFEELTDIERQFHKALYTVRTYLQCERYSVGLL 307
Query: 512 LLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ KE + ++F D + P + + E K
Sbjct: 308 DMTKEKVGLEFYDEW--PIKLGDVEPYK 333
>UniRef50_A2EY05 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Trichomonas vaginalis G3
Length = 922
Score = 178 bits (433), Expect = 6e-43
Identities = 141/575 (24%), Positives = 255/575 (44%), Gaps = 23/575 (4%)
Query: 251 NYILYQPIITKSGKT-SYVLEMWRTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRE 309
N ++ I SGK S VL + F DEE S I+ + + ++ C + ++
Sbjct: 358 NILVNVHIDVLSGKKWSLVLRGSQKLPIFTNCDEENSKIILPFLATSIQNC-MKINNSTS 416
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
N ++ + + I +E ++ ++ L+ L +DR L+ D N+ F+
Sbjct: 417 -NTEPRIIQMFEKISKEDNNIS-ILNETLKAITELTKSDRTVLYTNDANNNSYQIIAFE- 473
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
G +M + ++GI G + NI +A D ++ +D+ + Y+ S+
Sbjct: 474 ----G---NMNITNHFVAKDKGIVGRTFNEKKVFNIENASEDKDYDDSLDKKSNYEIKSV 526
Query: 430 LCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
L PI E V+ +Q+ NK D F D +FS F + + + + Q
Sbjct: 527 LSYPILNNEEDVVAAIQLSNKEDQNQFSQTDIKILSLFSKFISFVVENDQFKTQENNSLQ 586
Query: 489 KYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFY-LDPFRFDEFEKCKCIISMFRD 547
+ + +S ++ + + L + + N+ +FY +D FE I + F
Sbjct: 587 QDDEVSQFISKDEE-NKFIIPSKLENSKISNIFDLEFYTIDYIGTGLFEIAFKIFNEF-G 644
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ + Q + +F L +++NY PYHN+ H V Y + + ++ K+
Sbjct: 645 ILEKFQISSSLFLKFLLKLRRNYNNPPYHNWTHAIDVLQ--YVSYEIKLTNSHNHLKSQE 702
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIF 666
L++ VA LCHD+ H+G+ N Y +P ++ TS +E H + + ILQ+D N+F
Sbjct: 703 LLSVLVAALCHDVGHQGFNNAYNINVKTPFGILFKDTSVMETFHCAMAIKILQEDDTNLF 762
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
++ D + +I H ILATD+A F + ++ + S + + R M +
Sbjct: 763 YSLNDNDLSNVWSWIIHLILATDMAKHFKLIKEMNDTISS--RNLDMESENDRLCCMEMI 820
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVG 785
M AD+S ++P+ I K V+ +EF+ QGD E+ P+M R + + + Q+G
Sbjct: 821 MKVADISNVSRPFFIADKWCDVLQDEFWRQGDMEKQHELSYSSPLMSR-EGQNKAKGQIG 879
Query: 786 FLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
F +CIP Y ++ RI P NL W+
Sbjct: 880 FYKAVCIPLYSLVARIFPELNKSLDSVNANLKEWE 914
>UniRef50_A2E5S0 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1275
Score = 177 bits (431), Expect = 1e-42
Identities = 144/501 (28%), Positives = 235/501 (46%), Gaps = 39/501 (7%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPI 388
+L L+ I+ ++ L++ADR SLF++D +S+L STV D +K I +
Sbjct: 799 ALSGLLHHIMSTSRDLIDADRCSLFILDTNSSKLSSTVSD----------GQKAGIEITK 848
Query: 389 NRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMV 447
+GIAG+VA GE++NIPDAY D RF+R VD TGY+T SIL +PIK + IGVV+++
Sbjct: 849 GKGIAGYVAEKGESLNIPDAYKDPRFHRGVDNDTGYRTRSILAVPIKNNSNETIGVVELI 908
Query: 448 NK---RDDKYFGDDDEAAFEIFSTFFGLAL-HHARLYDRIMRKEQKYRVALEVLSYHNTC 503
NK ++ F +DE F+TF G+A H+ D + L +
Sbjct: 909 NKDIIKNGGVFTKEDEKLTSGFATFAGVAFDQHS---DNNRSGSHTLAIMLSNMMNAEEA 965
Query: 504 REYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDI--TTLTR 561
+ + E F F D E + + I+++F L +F I + L R
Sbjct: 966 NSFSPPKQIALNEEQMTRFDTFRFDVATVSEIDSARFIMTIFYKLGLSQRFKINNSRLIR 1025
Query: 562 FTLTVKKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDL 620
F L V Y P++N+ A +Y IL +D+K + +LAL V+ +CHD+
Sbjct: 1026 FILAVHDGYMKSPFYNWQRAVASAQFVYYILTTTDLK---NILTDLEKLALIVSTICHDI 1082
Query: 621 DHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILG 679
D+ + S T LA +Y +E HH T++IL++ NI ++++D +
Sbjct: 1083 DYTSVDDSNQS-TEIALAVLYHNRPVMEMHHCEHTISILERSEENILETLNADDSQSCWK 1141
Query: 680 FIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPW 739
I IL T++A F + ++ L ++ + HR L M + A+D S + + +
Sbjct: 1142 MIISLILGTNMAKHFNTVTTLQSLIFPNK-MINMKLEEHRLLIMQFIIKASDASYACRNF 1200
Query: 740 EIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLY 799
+ + ++ F D + A G+ + R SQVGF+ P + +L
Sbjct: 1201 PVCQREGTKAYKMFTD----KTAIGK----LFQRYLVN----SQVGFIILYAEPMFTLLT 1248
Query: 800 RILPNTKPMYAMATKNLNRWK 820
+ P+ P+ NL WK
Sbjct: 1249 HVFPSVDPLLEQVKLNLQYWK 1269
Score = 116 bits (279), Expect = 3e-24
Identities = 68/184 (36%), Positives = 109/184 (59%), Gaps = 12/184 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL V +++ E ++D L+ +IL A +LV+ADRASLF++D + L+S K G
Sbjct: 620 LLQVAESLSRE-TNIDTLVSQILVKACQLVSADRASLFVLDDSKNNLIS-----KVAHGT 673
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
D K +P+ +GI G VA +GET+NIPD Y D RFN +D+ TGY+T S++ +P+
Sbjct: 674 D-----KPFVLPVGQGIVGTVARTGETINIPDCYEDSRFNSAIDKKTGYRTKSMMTIPVH 728
Query: 436 VE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
+ +IGVVQ++NK++ + F D D + F G+AL ++ + D Q+ + L
Sbjct: 729 DQRHSIIGVVQLMNKQNGEAFSDADVELTKAMCVFTGIALANSIVIDSAFASSQRVQAML 788
Query: 495 EVLS 498
+ +S
Sbjct: 789 KTVS 792
>UniRef50_A2DG30 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1090
Score = 166 bits (403), Expect = 3e-39
Identities = 147/599 (24%), Positives = 273/599 (45%), Gaps = 38/599 (6%)
Query: 253 ILYQPIITKSGKTSYVLEMWR--TKDRFKVIDEEISGHIVVWGSVALHYCKLY-VDKKRE 309
I+ PI G+ + V E+ T D F D + V+ +AL +LY +
Sbjct: 448 IITVPIFNNRGEIAGVTELMNKITSDAFTEDDVSLLRGFNVFCGIALDNSRLYQASTELT 507
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
+ +S F+ V + + ++ + + IL+ A + A L+L+D +E ++ + L
Sbjct: 508 KQVSSFI--EVSSGLTKNTTMRNICESILQNAINICEAKSGILYLLD--GNEKITPLISL 563
Query: 370 KFEPGLDLDMEKK--EIRMPINRGIAGHVALSGETMNIP--DAYSDYRFNRDVDEATGYK 425
D + K+ E + + G+T P D ++ +R V+ A +
Sbjct: 564 NTNRETDQLIVKRCIENKSTVVMTFDEVNEYLGKTKGPPKQDKSLSHQLSR-VNAAMSRR 622
Query: 426 TI-------SILCMPIKV-EGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHA 477
+ SI +P+K +G V+GV+++ K + + E F+ F ++L
Sbjct: 623 ILPDMFTENSICLIPLKSSDGNVLGVMEV--DTTSKLM-TESQKLLECFAVFASVSLERN 679
Query: 478 RLYDRIMRKEQKYRVALEVL-SYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFE 536
L D + + ++ ++ V L + + +F D + +
Sbjct: 680 HLKDIAQLGSHEAELKQQMTRDERDSTTNIPVHLHLPQRTVTQLWTINF--DSLDWTDIG 737
Query: 537 KCKCIISMFRDLFDMTQ-FDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAH-AMYAIL 592
+ + ++F F++ Q F++T L RF + ++ YR VPYHN+ H V Y +
Sbjct: 738 YFQVVFAIF-SRFNLQQTFNVTNEKLYRFLIELRAGYRPVPYHNWAHAVDVLQFTAYQVH 796
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHF 651
S + E+ + AL VA +CHDL+H G+TN Y + +PL ++ S +E HH
Sbjct: 797 ISHLDEKIPKVEL---FALLVAAICHDLNHDGFTNDYNVKAETPLGILFKNQSVMEMHHC 853
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQF 711
+T+ I+ D N+FS + + +K++ + + ILATD+A F L + L D F
Sbjct: 854 EVTIDIMSNDQCNLFSALPPQQFKQVWNLVINLILATDMAKHFTILQEFNTLI--DGKTF 911
Query: 712 SWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM 771
S ++ +HR L + + + DLS ++P+++ + V+ EEF+ QGD E A G +
Sbjct: 912 SMENENHRHLLLQLIIKVGDLSNVSRPFDLANRWCAVLCEEFFRQGDLEMARGMQYSSAL 971
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKILFKQ 830
+ + + SQ+GF + +C+P Y + ++LP + NL WK+ AD+ K+
Sbjct: 972 NDREHLNKEKSQIGFYTSVCLPLYQSVAKVLPQLESNVVQVESNLETWKS-ADEAKIKK 1029
Score = 105 bits (252), Expect = 6e-21
Identities = 67/184 (36%), Positives = 104/184 (56%), Gaps = 12/184 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LLDV + + ++ +D LI I++ + L+ A+R SLFLV+ +EL+S F GL
Sbjct: 346 LLDVAEQL-SGVLDIDTLIPMIMQRSCDLLEAERCSLFLVNNTQTELISY-----FHAGL 399
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
EIR+PIN GI G A +GE + +AY D RF+ VD+ TG+KT +I+ +PI
Sbjct: 400 TT-----EIRIPINTGIVGVTATTGEIQVVNNAYEDPRFDSSVDKKTGFKTRNIITVPIF 454
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
G++ GV +++NK F +DD + F+ F G+AL ++RLY ++ +
Sbjct: 455 NNRGEIAGVTELMNKITSDAFTEDDVSLLRGFNVFCGIALDNSRLYQASTELTKQVSSFI 514
Query: 495 EVLS 498
EV S
Sbjct: 515 EVSS 518
>UniRef50_A7SVS5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 496
Score = 164 bits (399), Expect = 9e-39
Identities = 90/281 (32%), Positives = 151/281 (53%), Gaps = 9/281 (3%)
Query: 526 YLDPFRFDEFEKCKCIISMFRDLFDMTQFDI--TTLTRFTLTVKKNYRTVPYHNFDHGWT 583
Y + +++E E + M+ DL + +F I + L F V ++Y P+HNF H +
Sbjct: 173 YRNLSQWEEAEMLYLLQQMYIDLGLLDEFKIERSKLQHFLFEVYRHYNPTPFHNFRHAFC 232
Query: 584 VAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT 643
V MY ++ + E F+ L + + LCHDLDH GY N Y + LA Y
Sbjct: 233 VTQMMYGLIW--LTEIFNKITKQDLLIMLTSALCHDLDHPGYNNAYQINARTELALRYND 290
Query: 644 -STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRE 702
S LE+HH + I++QD NI ++S+E +K+I + CIL+TD+A L+K +E
Sbjct: 291 ISPLENHHCAVAFDIMKQDKSNILQNVSAETFKKIREGMIKCILSTDMARHSDILNKFKE 350
Query: 703 LYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERA 762
L +S F +DD +H+ + M I + +D+S A+P ++ + + +EF+ Q D E+
Sbjct: 351 LLKSG---FKFDDEAHKSMLMQIMIKVSDVSNEARPMDVAEPWLDCLLQEFFIQSDVEKL 407
Query: 763 AGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K +P++Q+GF+ + +P ++ L + P
Sbjct: 408 EGLPVAPFMDRDK-VTKPSAQIGFIKFVLVPLFEALGELFP 447
>UniRef50_A2FQ29 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1175
Score = 163 bits (397), Expect = 1e-38
Identities = 110/404 (27%), Positives = 196/404 (48%), Gaps = 17/404 (4%)
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
++C I + V+G V M K+ + F DD E +S F ++L + L M+
Sbjct: 759 MVCPIISSDRIVLGAVLMQWKKSNPQFNYDDLRLLESYSVFLSISLERSILKKIAMKGGA 818
Query: 489 KYRVALEVLSYHNTCREYEVQAM-LLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRD 547
+ + LS ++ Q + L+++E + DF P FD + K + +F +
Sbjct: 819 EVELQ-SWLSQSERFQQLIPQKLKLIEEERKMIYSIDF--TPVCFDGYGLFKVVFEVFME 875
Query: 548 --LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAH-AMYAILKSDVKERFDYNK 604
LF + TL RF V++ Y VPYHNF H V A+Y + KS ++ +
Sbjct: 876 FNLFQEFHINSETLFRFLHAVREGYNPVPYHNFLHAVDVMQFAVYLLKKSKLESEISKFE 935
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGH 663
L L ++CLCHD++H G++N Y + +PL +Y S LE HH ++ ++I+ ++
Sbjct: 936 I---LGLIISCLCHDINHDGFSNSYNEKAQTPLGILYKNQSVLETHHCSVCISIMTREDC 992
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAM 723
N+ ++ D +++ I + IL TD+A F L ++ ++ W + R +
Sbjct: 993 NLLKSLNISDTQKMWNLIINLILITDMAKHFEFLQELDKIINEKR---DWRQ-NDRQTIL 1048
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPAS 782
+ + +D+S + +E+ + V+ EEF+ QGD E+AAG P+ DR ++ S
Sbjct: 1049 QMIIKLSDISTIFRKFELADRWTAVLCEEFFRQGDLEKAAGMEYTSPLNDREHLDKSK-S 1107
Query: 783 QVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKI 826
Q+GF + +C+P + +IL +NL WK R +++
Sbjct: 1108 QIGFYTNVCLPFANKAAQILDGLDDALKNVNENLQTWKERVEQV 1151
Score = 121 bits (291), Expect = 1e-25
Identities = 74/188 (39%), Positives = 112/188 (59%), Gaps = 14/188 (7%)
Query: 294 SVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLF 353
+V +Y L K++ ++ LL+V + + E+ +D LI +I+ A LV A R SLF
Sbjct: 440 NVEKNYQSLDESMKQQTSLRS-LLEVAEILSGEL-KIDDLIPKIMARACELVMASRCSLF 497
Query: 354 LVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYR 413
LV+ +L++T + GL K I +PI GI G+ A +GE +NI DAY D R
Sbjct: 498 LVNDTRDKLITT-----YSGGL-----KNAIEVPIKSGIVGYTATTGEVLNIKDAYEDPR 547
Query: 414 FNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGL 472
FNR D TGY+T+++LC+PI +G V GV +M+NK D YF ++D +IF+ F G+
Sbjct: 548 FNRATDLKTGYRTVTVLCVPIFDNKGIVRGVTEMINKIDG-YFSEEDVKLIQIFNVFTGI 606
Query: 473 ALHHARLY 480
+L +A+LY
Sbjct: 607 SLDNAQLY 614
>UniRef50_UPI0000D56333 Cluster: PREDICTED: similar to
cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic
GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE);
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
cGMP-dependent 3,5-cyclic phosphodiesterase (Cyclic
GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) -
Tribolium castaneum
Length = 666
Score = 162 bits (394), Expect = 3e-38
Identities = 124/456 (27%), Positives = 209/456 (45%), Gaps = 25/456 (5%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
++ R+R + LLD + + + + +LI I ++L+NA + SLFL + + L+S
Sbjct: 205 EEARQRKQYETLLDATRKFYSHIDDIHELITVITNETRQLINARKCSLFLANLDDLLLIS 264
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
K+ L+ K +++ ++ I HVA +G +N FN + E +
Sbjct: 265 R----KYNTPLEAKKCKPCVKLALHFAIPDHVANTGTLINCHRNQESALFNESLMEFNEF 320
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
K +ILC P++ E K+IG VQ+ NKR + D+E A I S G AL + + +
Sbjct: 321 KLQNILCFPVRDEDKIIGAVQLYNKRKGNFTRFDEEIA-NILSVHGGFALSQSLKFTKSE 379
Query: 485 RKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYL---DPFRFDEFEKCKCI 541
+ + ++A ++ H EV + PL + +F L P E +
Sbjct: 380 NFKIRNQLADNLMIRHEHVNMDEVMKKIAC--PLIHQYPNFELFTFSPRSIVSLETTCLV 437
Query: 542 ISMFRDLFDMTQFDI--TTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKER 599
MF L T F I +FT+TVK R VP+HN+ H ++ AH Y L
Sbjct: 438 FKMFERLGFFTTFGIKREVFAKFTMTVKNCCREVPFHNWMHLFSTAHFAYLCLTHLQLVE 497
Query: 600 FDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT--STLEHHHFNITVTI 657
Y LA FV CLCHD+D+R + + + L +Y++ S +E H + + I
Sbjct: 498 DKYITQLEALAYFVTCLCHDVDYRAANSSFQQTPSDGLCTLYSSPGSVMERHRLSQILRI 557
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPS 717
L +G N ++ E+Y+ L ++ LATDL+ F + K + + D W
Sbjct: 558 LNSEGCNFVDILNRENYRLFLDLLKDLTLATDLSIHFKHYTK-KFIMTKD-----W--TV 609
Query: 718 HRDLAMAI---SMTAADLSASAKPWEIQIKTVKVIF 750
+D+A+ + T DL + +Q+K ++V+F
Sbjct: 610 SKDVAIQLFQEFFTQGDLEVNYYSNPLQMKDIEVVF 645
>UniRef50_A7SYX3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 466
Score = 161 bits (390), Expect = 1e-37
Identities = 85/235 (36%), Positives = 138/235 (58%), Gaps = 4/235 (1%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
++E+ + + ++ + +L+ + E + LL + K+IFEE ++D + I+ A
Sbjct: 232 EDEVFKDYLTFCAIGITNAQLFETSELEFKRNQVLLQLAKSIFEEQTNVDDCVNNIIVQA 291
Query: 342 QRLVNADRASLFLVDYR---NSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVAL 398
Q L+ +R +FL+D + S FD++F+ D + ++ GIA VA
Sbjct: 292 QALLQCERCMVFLIDDSPGTQGVVFSKAFDIQFKEDEDAVLSTPSSYWSVDTGIAFWVAT 351
Query: 399 SGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGD 457
SG+ +NIPDAYSD RF+ + D+A+G+ T SILCMPI E +IGVVQ++NK D K F +
Sbjct: 352 SGQVVNIPDAYSDDRFSPEADQASGFVTKSILCMPIYNREQNIIGVVQLMNKLDGKPFSE 411
Query: 458 DDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAML 512
DE+ FE F+ F GL +++ +LY+ + K +VA+EVLSYH + + EV +L
Sbjct: 412 SDESIFEAFAIFCGLGINNTKLYEEACKLLTKQKVAMEVLSYHASAQPAEVHKIL 466
Score = 100 bits (239), Expect = 2e-19
Identities = 58/126 (46%), Positives = 78/126 (61%), Gaps = 5/126 (3%)
Query: 314 DFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSELVSTVFDLKF 371
D +++++ I E+ +++L +IL L NADR SLFL N LVS +FD+
Sbjct: 105 DKFMELIRDIANEL-DINRLSHKILVNVSVLTNADRGSLFLTHGSKENRVLVSKLFDVTT 163
Query: 372 EPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
++ + E +I +P +GIAG A SGE +NI DAYSD RFNRDVD+ TGY T SI
Sbjct: 164 ASSVEESIQNEDDQIVVPFGKGIAGCAAESGEAINIKDAYSDPRFNRDVDKKTGYTTHSI 223
Query: 430 LCMPIK 435
LCMPIK
Sbjct: 224 LCMPIK 229
>UniRef50_A2FQB0 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1042
Score = 161 bits (390), Expect = 1e-37
Identities = 136/576 (23%), Positives = 259/576 (44%), Gaps = 40/576 (6%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKD--RFKVIDEEISGHIVVWGSVALHYCKLYVDK-KRE 309
IL PI GK V EM K+ F + D + V+ ++L +LY +
Sbjct: 493 ILSVPIFNNRGKIIGVTEMINKKNGQAFSMWDTNLIQIFNVFCGISLENARLYNESIDMS 552
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
+ + F + + + +++ I++ A+R + A RAS+F+VD N +++ +V
Sbjct: 553 KKLKSFF--GISFSVNKTEDIKRILSDIMKNARRGLQAKRASIFVVDDTNKQILRSVI-- 608
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
+D K ++ GI G + + + D ++ R+N VDE TG++T +I
Sbjct: 609 -------VDGGKIPATFNVSEGIIGACVRTKQAIFTNDPKNEPRWNPKVDEVTGFQTTNI 661
Query: 430 LCMP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
L +P I EG V+GVV+MVNK + K F D D + F +F + + ++R
Sbjct: 662 LAVPLISTEGDVMGVVEMVNKINGK-FSDADVMLLQAFCSFAAITIENSR---------N 711
Query: 489 KYRVALEVLSYHNTC-REYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIIS--MF 545
K + V S + V+ M + E + F F + E + + S +
Sbjct: 712 KQLAPMSVRSARPVIFNDRNVEKMAMTTEQME-GMTGISFCAFDFGDEELVRMVFSNLVI 770
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKS-DVKERFDYNK 604
+ + + + TL F L V+ Y VPYHN+ H V + +L+S + KE F+ +
Sbjct: 771 FGVPENMRTNHETLLHFILQVRLLYNDVPYHNWRHACDVVQFVSFVLQSINAKEIFEPIE 830
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEH-HHFNITVTILQQDGH 663
S A+F+A +CHD H GY+N + + ++PL +Y+ E H ++ ++
Sbjct: 831 IS---AIFIAAICHDAGHDGYSNIFNRQASTPLGQIYSGKNCEELFHLSLIARVVNSPEC 887
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAM 723
NIFS+++ + + I+ TDL F + + + + + R +
Sbjct: 888 NIFSNMTHATMAKFWAMMIRMIIDTDLEVF------SQVMSNNSLNNLDMKNQNSRIKVL 941
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQ 783
++ + +++S A+P+++ ++ + + E+Y QGD E++ G + + ++P Q
Sbjct: 942 SLILILSNISNVARPFDVAMRWLDCLSTEYYKQGDIEKSLGMKYTNVANNRALPDKPKEQ 1001
Query: 784 VGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
F++ +P ++ + P + NL W
Sbjct: 1002 SNFINTYALPLSKVVATLFPALDVICKSIATNLVEW 1037
Score = 109 bits (261), Expect = 4e-22
Identities = 74/202 (36%), Positives = 109/202 (53%), Gaps = 15/202 (7%)
Query: 294 SVALHYCKLYVDKKR---ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRA 350
S +L+Y + D K+ ER LL+V + I + + +L + I+E L +DR
Sbjct: 366 SNSLNYTGVLSDFKKTTEEREGLSALLEVAE-ILSRQLDIGRLCEIIMEKGCYLTKSDRC 424
Query: 351 SLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYS 410
SLFLV L + KF GL +E +PIN+GI G + +NI DAYS
Sbjct: 425 SLFLVSQDGKSLTT-----KFHRGLTNGIE-----IPINKGIVGKTVTQAKPLNIHDAYS 474
Query: 411 DYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTF 469
D FN D ATGYKT +IL +PI GK+IGV +M+NK++ + F D +IF+ F
Sbjct: 475 DPDFNVATDIATGYKTKTILSVPIFNNRGKIIGVTEMINKKNGQAFSMWDTNLIQIFNVF 534
Query: 470 FGLALHHARLYDRIMRKEQKYR 491
G++L +ARLY+ + +K +
Sbjct: 535 CGISLENARLYNESIDMSKKLK 556
>UniRef50_A2EIP4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1334
Score = 158 bits (384), Expect = 6e-37
Identities = 119/408 (29%), Positives = 204/408 (50%), Gaps = 27/408 (6%)
Query: 429 ILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKE 487
I C+P+ E +GV+++ + K +D + E FS F +++ R+ + E
Sbjct: 939 ICCLPLMSSEAATLGVIEI--SCNWKILSEDVKL-LECFSVFASVSIEIFRMKEVATLGE 995
Query: 488 QKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVD-FADFYLDPFR---FDEFEKCKCIIS 543
A E+ S+ E ++ + + +K +N+ + + F +D K + +
Sbjct: 996 ----AASEMKSWIAD-NELQLTSKIPNKLTINMSKLSSVLMVKFNAPDWDGIGLIKVVYA 1050
Query: 544 MFRDLFDMTQ-FDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAM-YAILKSDVKER 599
+F D+FD+ Q F +T L RF ++ NY+ VPYHN+ H V + Y IL S
Sbjct: 1051 IF-DIFDINQTFGVTNERLFRFLSEIRDNYKKVPYHNWRHAVDVMQFVAYQILVSGCNTI 1109
Query: 600 FDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTIL 658
+ A+ VACLCHD+ H G+TN + + +PL ++ S +E HH ++++ IL
Sbjct: 1110 LSKFEI---FAILVACLCHDVGHDGFTNAFNEKAETPLGLLFKNQSVMETHHCSVSIGIL 1166
Query: 659 QQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWD-DPS 717
++ NIFS + +YK + I ILATD+A F L I + R D +F + +
Sbjct: 1167 SKEECNIFSKLQPNEYKNMWILIIRLILATDMAKHFDILKDINQ--RVDNGEFDLQKNEN 1224
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
R + I + D+S ++P+E+ K V+ EEF+ QGD E+A+G P+ DR
Sbjct: 1225 DRYSFLEILIKCGDVSNVSRPFELANKWCDVLCEEFFRQGDLEQASGMEYTSPLNDR-AH 1283
Query: 777 EEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
++P SQ+GF + +C+P + +I+P + NL +WKA +
Sbjct: 1284 LDKPKSQIGFYTAVCLPLFQTAAKIMPKLQCNVDQVQSNLAQWKAEIE 1331
Score = 129 bits (312), Expect = 3e-28
Identities = 84/242 (34%), Positives = 135/242 (55%), Gaps = 20/242 (8%)
Query: 268 VLEMWRTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDF------LLDVVK 321
+L+ + K F +DE + + AL + L++ K + + F LL+V +
Sbjct: 346 ILKSPKGKPTFSALDENKLQVTIPFACRALSF--LFLPKSLDEEIDQFETRLKSLLEVAE 403
Query: 322 AIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEK 381
I ++ +D L+ I+ A +L++ +R SLFLVD ++ELV+ +F GL
Sbjct: 404 -ILSGVLDIDTLLPTIMNHATKLLSCERCSLFLVDAAHNELVT-----RFHGGLS----- 452
Query: 382 KEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKV 440
IR+ I RGI G A SG+ +NI DAY+D RF+R VD ATG+ T S+LC+PI+ G++
Sbjct: 453 NAIRVKIGRGIVGSCAQSGDIVNIKDAYADSRFDRSVDLATGFTTRSLLCIPIENNRGEI 512
Query: 441 IGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYH 500
GV +M+NK +D F DDD F+ F G+++ +ARLY + ++ R +E+ +
Sbjct: 513 TGVTEMINKLNDGLFDDDDIKMLLAFNVFCGISIDNARLYKASLDLTRQLRSFIEMTASL 572
Query: 501 NT 502
NT
Sbjct: 573 NT 574
>UniRef50_A2EHB3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1213
Score = 157 bits (380), Expect = 2e-36
Identities = 111/401 (27%), Positives = 190/401 (47%), Gaps = 16/401 (3%)
Query: 428 SILCMPIKVEGKVI-GVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
S++C+PI +V+ G V M K+ + F DD E +S F L+L +L + + +
Sbjct: 768 SLICVPILSSDRVVMGAVLMRWKKSQQKFTQDDLKLLESYSVFLSLSLERFKLKN--IAQ 825
Query: 487 EQKYRVALEVLSYHNTCREYEVQAMLL--DKEPLNVDFADFYLDPFRFDEFEKCKCIISM 544
V ++ + + E V LL D+E + +F ++ K I
Sbjct: 826 LGSLEVEMQNVMSNEERGEMRVPTKLLMSDEECGALLLRNFESTEWKGMALFKVAFNIFN 885
Query: 545 FRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGW-TVAHAMYAILKSDVKERFDYN 603
+LF + + F +K +Y VPYHNF H T+ + I+ +K+
Sbjct: 886 TFNLFKKFKISASCFFSFLFEMKNSYLPVPYHNFTHAIDTMQFMAHVIILCGLKDVLTQK 945
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDG 662
+ L L VAC+CHD +H G++N Y + +PL+ ++ S LE HH ++++TIL +D
Sbjct: 946 EI---LILLVACICHDANHDGFSNNYNYKAQTPLSILFKGQSVLETHHCSVSITILSKDE 1002
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW-DDPSHRDL 721
+F++ ++ + ++ATD++ F +D++RE +W D P R L
Sbjct: 1003 SALFNNFPDDEIASVWTLFIDLVMATDMSKHFDIVDEMREYLAMG---LTWKDHPKGRLL 1059
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
M + + AAD+S + +E + V+ EEF+ QGD ERA G P+ +R +Q
Sbjct: 1060 FMKLLIKAADISNCVREFETADRWADVLCEEFFRQGDLERALGMEYDGPLHERQHLNKQ- 1118
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKA 821
SQ+GF + +P Y ++ RI P N+ +W A
Sbjct: 1119 KSQLGFYKSVALPLYLLMERIEPGFSVFVTNVKNNMEKWAA 1159
Score = 118 bits (283), Expect = 1e-24
Identities = 75/174 (43%), Positives = 103/174 (59%), Gaps = 13/174 (7%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVF 367
R++ LL+V + + ++ +D LI I+ A LV ADR SLFLV+ + +L T
Sbjct: 467 RQQKRLRSLLEVAETLSGQL-RMDVLIPNIMSRACDLVKADRCSLFLVNDSHDKLQMT-- 523
Query: 368 DLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTI 427
F GL K I +PIN GI G A GE +NI DAY D RFNR D ATGY+T+
Sbjct: 524 ---FGAGL-----KNTIEIPINAGIVGWSATKGEILNIKDAYDDPRFNRGTDLATGYRTL 575
Query: 428 SILCMPIKVEGKVI-GVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+IL +PI + K I GV +M+NK D F +DDE +IF+ F G+++ +ARLY
Sbjct: 576 TILSVPIFDDKKGIRGVTEMINKLDG-VFTEDDEKLIQIFNVFCGISIENARLY 628
>UniRef50_UPI0000D577EC Cluster: PREDICTED: similar to CG32648-PA;
n=2; Coelomata|Rep: PREDICTED: similar to CG32648-PA -
Tribolium castaneum
Length = 938
Score = 156 bits (379), Expect = 2e-36
Identities = 92/281 (32%), Positives = 139/281 (49%), Gaps = 10/281 (3%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKS-DVKERFDYNKA 605
DL DI TL F KNY VP+HNF H + VA MYAI S D+ + +
Sbjct: 218 DLCSKFAIDINTLRNFLYEAYKNYNDVPFHNFRHCFCVAQMMYAISWSVDLPSKVGDLEV 277
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHN 664
L L +C+CHDLDH GY N Y + LA Y S LE+HH ++ IL+ + N
Sbjct: 278 ---LILLTSCICHDLDHPGYNNIYQINAKTELAIRYNDISPLENHHCSVAFRILENEDCN 334
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
IF SED+K + I CILATD+A L RE+ F ++D +H +L
Sbjct: 335 IFKSFKSEDFKTVREGIIRCILATDMARHNEILTNFREI----TPNFDYNDKAHVNLLCM 390
Query: 725 ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQV 784
+ + +D+S A+P ++ + + +EF+ Q D E+ G P MDR K +P+SQ
Sbjct: 391 VLIKVSDISNEARPMDVAEPWLDRLLQEFFKQSDAEKLEGLPVTPFMDREK-ITKPSSQC 449
Query: 785 GFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
F+ + +P ++ L +L + + + + R ++
Sbjct: 450 SFIGFVLLPLFEALGDLLTELQDLIVQPVREALEYYRRLNE 490
>UniRef50_A2FKH2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1086
Score = 155 bits (375), Expect = 7e-36
Identities = 113/406 (27%), Positives = 200/406 (49%), Gaps = 19/406 (4%)
Query: 428 SILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
SI +P+ G ++GV+++ + + K +D + + F+ F +A+ A L D + +
Sbjct: 666 SICSIPLMDSSGIILGVMEL--ECNWKIINEDMDI-LDCFAVFASVAIERANLKD--IAE 720
Query: 487 EQKYRVALEVLSYHNTCREYEV-QAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMF 545
+ + L+ + Y V Q+ L +E ++ F D +D K I ++F
Sbjct: 721 HGQVEIDLKHWLTESERDGYSVPQSFQLPQEVID-GFFTVNFDAPMWDGIGHFKVIFNIF 779
Query: 546 RDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAM-YAILKSDVKERFDY 602
+ F +T RF ++ Y+ VPYHN+ H V + Y ++ S +D
Sbjct: 780 HHFGVLQIFKVTNEKFFRFLTALRDKYKKVPYHNWRHAVDVTQFVTYELITSG----YDK 835
Query: 603 NKASSRL-ALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQ 660
+S L L VACLCHD +H G+TN Y + +PL ++ S +E HH I + I+ +
Sbjct: 836 ILSSFELYGLLVACLCHDANHDGFTNVYNVKAETPLGILFKNQSVMETHHCAIAIDIISK 895
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRD 720
+ NIF+ ++ +YK++ I + IL TD+A F L + L+ + E + ++P H
Sbjct: 896 EETNIFASLNPAEYKKMWSLIINLILITDMAKHFTFLKEFNGLFDAGEWK-PKENPQHFL 954
Query: 721 LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQP 780
+ M + + D+S ++P+E+ K V+ EEF+ QGD E+A G ++ ++P
Sbjct: 955 MLMQMLLKCGDISNVSRPFELADKWCDVLCEEFFRQGDLEQAQGMNYTSDLNDRAHLDKP 1014
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW-KARADK 825
SQ+GF + +C+P Y + +P + NL W KA+ DK
Sbjct: 1015 KSQIGFYTFVCLPLYQATAKAIPKLQVNVDQVNSNLAIWKKAQEDK 1060
Score = 125 bits (301), Expect = 6e-27
Identities = 67/166 (40%), Positives = 105/166 (63%), Gaps = 12/166 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL++ +A+ ++ ++ LI I+E A L++A+R SLFLVD LV+ F+ GL
Sbjct: 358 LLEIAQAL-SGVLDIETLIPTIMERACNLLHAERCSLFLVDKGKQSLVT-----HFQSGL 411
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
D K + +P+ RGI GH A++G +NI DAYSD RF+R +D+ TG++T+S+L +PI
Sbjct: 412 D-----KALTIPLTRGIVGHTAITGNVVNIKDAYSDTRFDRTIDQTTGFRTVSLLTVPIY 466
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
G++ GV +M+NK D + F +DD F+ F G +L +A+LY
Sbjct: 467 NNRGEITGVTEMINKLDGEGFTEDDVRMMHPFNVFCGTSLDNAKLY 512
>UniRef50_A2DF08 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1040
Score = 153 bits (370), Expect = 3e-35
Identities = 149/604 (24%), Positives = 270/604 (44%), Gaps = 56/604 (9%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
IL PI G+ + V EM D+F D ++ V+ ++L KLY
Sbjct: 445 ILCLPIYNNRGEIAGVTEMINKIGSDKFDADDIKMLMAFNVFCGISLDNAKLYQASLDLT 504
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
+D+ A+ + ++ IL A + ++ RA+++ +D N +L V +
Sbjct: 505 KQLRTFVDLSAAL-SHADKIRNALQSILMSAMKAMDGLRATIYHIDQTNGKLTKLV-NAG 562
Query: 371 FEPGLD-----LDMEK--------KEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRD 417
EP D L ++K +EI +N G A + ++ + M++ ++ R R
Sbjct: 563 IEPKYDTIFAQLALQKLAPQIFGAQEIEEIVNSG-ADNKSVQDDNMSVKSNKANERQRRI 621
Query: 418 VDEAT------------GYKTISILCMPIKV-EGKVIGVVQMVNKRDDKYFGDDDEAAFE 464
T G ++I+C P+ E +GV+++ +++ E
Sbjct: 622 ASIITRNASIETMKSGGGAAEVNIVCSPMLTSENTPLGVLEIETAVK---MMNENLKLLE 678
Query: 465 IFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFAD 524
FS F +++ +L D I++ Q R +++S + + L K P + +
Sbjct: 679 CFSVFAAISIEKFQLID-IVKLGQGERELKQMIS--------DEERTLTTKIPEKMSIEN 729
Query: 525 FYLDPFRFDEFEKCKCIISMFRDLF---DMT-QFDITT--LTRFTLTVKKNYRTVPYHNF 578
+ FD I++ ++F D+ +F+IT L RF ++ Y+ VPYHN+
Sbjct: 730 DSIWKRHFDAQLWADQYITVLFNIFYRFDLPKEFNITNEKLFRFLTEIRDTYKKVPYHNW 789
Query: 579 DHGWTVAH-AMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPL 637
H V +Y +L+S + + AL V+ +CHD +H G+TN Y + +PL
Sbjct: 790 RHAVDVTQFVVYELLESGCDKVLTKFEV---FALLVSAVCHDANHDGFTNVYNVKAETPL 846
Query: 638 AAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN 696
++ S +E HH + + ++ ++ NIFS +++ D + + I IL+TD+A F
Sbjct: 847 GILFKNQSVMETHHCQVAIGVISKEECNIFSALNAGDNRTMWMTIISLILSTDMAKHFEI 906
Query: 697 LDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQ 756
L + D +FS ++ HR L M + + AD+S ++P++I + ++ EEF+ Q
Sbjct: 907 LKNFNAIM--DAGEFSMENKDHRILLMQLLLKTADISNVSRPFDIANRWCDILCEEFFRQ 964
Query: 757 GDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNL 816
GD E A G ++ ++P SQ+GF + +C+P Y L R P NL
Sbjct: 965 GDLEMAQGMEYTSDLNDKAHLDKPKSQIGFYTFVCLPLYQALARAFPQLSVNVKSVQSNL 1024
Query: 817 NRWK 820
WK
Sbjct: 1025 AIWK 1028
Score = 130 bits (314), Expect = 2e-28
Identities = 75/182 (41%), Positives = 110/182 (60%), Gaps = 12/182 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LLD+ + + + +D LI I++ A +L+ ++R SLFLVD ELV+ F GL
Sbjct: 343 LLDIAQNL-SGTLDIDVLIPTIMDRAIQLLKSERCSLFLVDQTKQELVT-----HFHGGL 396
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
D EIRMP+NRGI GH A++GET+NI DAY D RF++ VD TGY+T SILC+PI
Sbjct: 397 DT-----EIRMPMNRGIVGHCAMTGETVNIEDAYLDSRFDKTVDLKTGYRTKSILCLPIY 451
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
G++ GV +M+NK F DD F+ F G++L +A+LY + ++ R +
Sbjct: 452 NNRGEIAGVTEMINKIGSDKFDADDIKMLMAFNVFCGISLDNAKLYQASLDLTKQLRTFV 511
Query: 495 EV 496
++
Sbjct: 512 DL 513
>UniRef50_O76083 Cluster: High affinity cGMP-specific 3',5'-cyclic
phosphodiesterase 9A; n=62; Eumetazoa|Rep: High affinity
cGMP-specific 3',5'-cyclic phosphodiesterase 9A - Homo
sapiens (Human)
Length = 593
Score = 152 bits (369), Expect = 4e-35
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 262 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 321
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 322 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 378
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 379 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 438
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 439 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 494
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 495 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 533
>UniRef50_Q7PQX7 Cluster: ENSANGP00000010843; n=6; Coelomata|Rep:
ENSANGP00000010843 - Anopheles gambiae str. PEST
Length = 547
Score = 151 bits (366), Expect = 8e-35
Identities = 89/280 (31%), Positives = 150/280 (53%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDI--TTLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + +++++ + +MF +L + +F+I TL + V K+Y VP+HN+ H + VA
Sbjct: 50 DSYEWEDWDVIHLMQTMFVELNLLEKFNIPIVTLREWLYEVYKHYNDVPFHNYRHCFCVA 109
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY I +++ +R + L L V+C+CHDLDH GY N Y + LA Y
Sbjct: 110 QMMYTIAWHTNLVQRLGELEV---LVLLVSCICHDLDHPGYNNIYQINARTELALRYNDI 166
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH +I +L+ NIF ++S E YK++ I CILATD+A ++I
Sbjct: 167 SPLENHHCSIAFRLLEHPECNIFRNMSKEMYKDVREGIIRCILATDMARH----NEILTQ 222
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
++ +F + + H +L + + AD+S A+P ++ V + +EF+ Q E++
Sbjct: 223 FQEATPEFDYSNKVHTNLLCMVLIKVADISNEARPMDVAEPWVDRLLQEFFAQSAAEKSE 282
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MD +K +P SQV F+ + +P ++ L +LP
Sbjct: 283 GLPVTPFMDPDK-VSKPGSQVRFIGLVLLPLFEALGELLP 321
>UniRef50_A2F408 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1086
Score = 151 bits (365), Expect = 1e-34
Identities = 107/403 (26%), Positives = 194/403 (48%), Gaps = 16/403 (3%)
Query: 429 ILCMP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKE 487
I C+P I EG+VIGV+ +++ + ++D + + F+ F ++L + L D
Sbjct: 663 ICCLPLINSEGEVIGVMLLMSIQR---MMNEDMSLLDCFAIFAAVSLERSELKDIAKLGS 719
Query: 488 QKYRVALEVL-SYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFR 546
++ + V + + V+ L +E + F D ++ K + ++F
Sbjct: 720 IEFELKEWVADNERELTNQIPVKLQLPIEESSKLWIVSF--DAPKWAGIGFFKEVFAIFA 777
Query: 547 DLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
+ I+ L RF ++ Y VPYHN+ H V + Y I+ S ++
Sbjct: 778 RFKFQENYGISNEKLFRFLCELRDTYNKVPYHNWRHACDVTQFVTYEIILSGAEKILSNM 837
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
+ AL VA LCHD +H G+TN + + +PL ++ S +E HH + + I+ ++
Sbjct: 838 EL---FALIVAALCHDANHDGFTNVFNEKAETPLGILFKNQSVMETHHCEVAIGIISKEE 894
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
N+F+ + S+D+K + I ILATD++ F L + + L +DE ++ P R
Sbjct: 895 TNLFAKLKSQDFKFMWTTIIELILATDMSKHFTLLKEFKAL--NDEGKWDKTQPDIRLRM 952
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M + + AD+S ++P+E+ + V+ EEF+ QGD E A+G ++ + ++P S
Sbjct: 953 MKLLLKTADISNVSRPFELADRWCDVLCEEFFRQGDLEMASGMQYTSDLNDREHLDKPKS 1012
Query: 783 QVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
Q+GF + +C+P Y + P + NL WKA +K
Sbjct: 1013 QIGFYTFVCLPLYQATAQAFPPLEVNVQQVQSNLAVWKAAFEK 1055
Score = 122 bits (295), Expect = 3e-26
Identities = 80/213 (37%), Positives = 121/213 (56%), Gaps = 12/213 (5%)
Query: 285 ISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRL 344
IS +V S A K+ K+ + LL+V +A+ +V +DQLI I+E + L
Sbjct: 338 ISSFVVQSVSSAFLPEKVDSQKQNFQERLHALLEVAEALSGILV-IDQLIPMIMEKSCSL 396
Query: 345 VNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMN 404
+NA+R SLFLVD EL + F GL IR+P+ GIAG A +GET+N
Sbjct: 397 LNAERCSLFLVDVVKKELKTF-----FHGGL-----ANAIRIPLTSGIAGKTATTGETIN 446
Query: 405 IPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAF 463
I DAY+D F+R +D TGY+T SIL PI G++IGV +M+NK +D F ++D
Sbjct: 447 IQDAYNDVNFDRSIDAKTGYRTKSILATPIYNNRGEIIGVTEMINKCNDGIFDEEDIRLL 506
Query: 464 EIFSTFFGLALHHARLYDRIMRKEQKYRVALEV 496
F+ F G++L +A+LY+ + ++ R +++
Sbjct: 507 IGFNVFCGISLDNAKLYEASLNLARQVRSFVDI 539
Score = 35.5 bits (78), Expect = 6.7
Identities = 43/196 (21%), Positives = 86/196 (43%), Gaps = 18/196 (9%)
Query: 307 KRERNMSDFLLD---VVKAIFE--EMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE 361
K+ N S F+ D ++K+ + ++ SL I I +L+ +A ++L R +
Sbjct: 187 KKFTNYSSFIFDSPQILKSSYSCVQIESLQNTINNICAAVTKLMRCRKAEIWLFRRRKN- 245
Query: 362 LVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
+F LKF+ ++ E + GIAG+V + T++ + + +N D
Sbjct: 246 ----IF-LKFDTISAEEIPVSEAKT----GIAGYVLTTCSTVSERNVCDNANYNPTSD-- 294
Query: 422 TGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYD 481
G+ + L +P + K + V + YF +D A S+F ++ A L +
Sbjct: 295 -GFYPEAFLGVPFVEKTKRVWCVVCRGRSSPPYFTPNDTAKLTAISSFVVQSVSSAFLPE 353
Query: 482 RIMRKEQKYRVALEVL 497
++ ++Q ++ L L
Sbjct: 354 KVDSQKQNFQERLHAL 369
>UniRef50_A2ENJ2 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1087
Score = 149 bits (361), Expect = 3e-34
Identities = 85/285 (29%), Positives = 142/285 (49%), Gaps = 7/285 (2%)
Query: 541 IISMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKE 598
+ +F + +FDI+ RF + Y+ VPYHN+ H V Y + +
Sbjct: 796 VFGIFNHFDLLREFDISNEKFFRFLSAISATYKKVPYHNWRHAVDVTQ--YVTFELETSG 853
Query: 599 RFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI 657
AL VA +CHD +H G+TN Y + +PL ++ S +E HH + +++
Sbjct: 854 IVSKLTKFDIFALLVAAICHDANHDGFTNVYNVKAETPLGILFKNQSVMETHHCAMAISV 913
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPS 717
+ ++ NIF+ +++E YK+I I + ILATD+A F L +I + DE + S D+P
Sbjct: 914 ISKEETNIFAKLNAEQYKKIWTTIINLILATDMAKHFTFLKEINGI--MDEGKLSIDNPD 971
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPE 777
+ + + AD+S ++P+E+ K V+ EEF+ QGD E A G ++
Sbjct: 972 DVSYYLELILKCADISNVSRPFELADKWCDVLCEEFFRQGDLEMAQGMQYTSDLNDRSHL 1031
Query: 778 EQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKAR 822
+P SQ+GF + +C+P ++ R +P + NL WK R
Sbjct: 1032 NKPKSQIGFYTFVCLPLFEAAARAMPPLQCNVDQIRSNLEVWKER 1076
Score = 117 bits (282), Expect = 1e-24
Identities = 64/166 (38%), Positives = 104/166 (62%), Gaps = 12/166 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL+V +A+ ++ +D L+ I+ A +L++ +R SLFLVD EL++ +F+ GL
Sbjct: 378 LLEVAEAL-SGVLDIDTLVPMIMTRACQLLHTERCSLFLVDNEKKELIT-----RFQGGL 431
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
+ K IR+P++RGI G+ +G +NIPDAY+D RF++ VD+ TGY T +++ +PI
Sbjct: 432 N-----KSIRIPMSRGIVGYTVTTGNIVNIPDAYADPRFDQSVDKKTGYHTRNLVTVPIF 486
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
++GV +M+NK D F D+D F+ F G++L +ARLY
Sbjct: 487 NNRNDIVGVTEMINKIDGDCFDDEDLKMVVAFNVFCGISLDNARLY 532
>UniRef50_Q16VA1 Cluster: High-affinity cgmp-specific 3,5-cyclic
phosphodiesterase; n=1; Aedes aegypti|Rep: High-affinity
cgmp-specific 3,5-cyclic phosphodiesterase - Aedes
aegypti (Yellowfever mosquito)
Length = 1022
Score = 148 bits (358), Expect = 8e-34
Identities = 88/280 (31%), Positives = 150/280 (53%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + +++++ + +MF +L + +F I TL + V K+Y VP+HN+ H + VA
Sbjct: 55 DSYEWEDWDVIHLMQTMFVELNLLEKFQIPRETLREWLYEVYKHYNDVPFHNYRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MYAI +++ +R + L L V+C+CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYAITWHTNLVQRLGELEV---LILLVSCICHDLDHPGYNNIYQINARTELALRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH +I +L+ NIF ++S + YK++ I CILATD+A ++I
Sbjct: 172 SPLENHHCSIAFRLLEHPDCNIFRNMSKDLYKDVREGIIRCILATDMARH----NEILTQ 227
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
++ F +++ H +L + + AD+S A+P ++ + + +EF+ Q E++
Sbjct: 228 FQEATPVFDYNNKVHTNLLCMVLIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MD +K +P SQV F+ + +P ++ L +LP
Sbjct: 288 GLPVTPFMDPDK-VSKPGSQVRFIGLVLLPLFEALGELLP 326
>UniRef50_A2FK96 Cluster: GAF domain containing protein; n=3;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1174
Score = 148 bits (358), Expect = 8e-34
Identities = 142/580 (24%), Positives = 241/580 (41%), Gaps = 41/580 (7%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKD--RFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
IL PI G +M D F D E+ V+ +AL +LY +
Sbjct: 621 ILCVPIRNNDGSIMGCTQMINKLDGNEFTKTDIELMSAFNVFCGIALSNAQLYESATITK 680
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
+LD+V + +L+QL+ ++ A+ LV + +F +D R + +
Sbjct: 681 KKMSAILDIVLNM-SSTSTLNQLVTNLMSNAKDLVESKYVFIFAID-RERHICHPI---- 734
Query: 371 FEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISIL 430
I N + G VA SG +N D D RFN G K SIL
Sbjct: 735 --------AVNDTISFSTNEDVVGFVATSGGEVNEEDPTQDRRFNTMFLSQMGIKPNSIL 786
Query: 431 CMPIKVE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHH--ARLYDRIMRKE 487
+PI +VIGV++ V+K F DD+ + FS F GLA+ A+ + + E
Sbjct: 787 AIPILDSLNQVIGVIEAVDKVGSPKFTADDQLLLKNFSAFAGLAMQRWMAKSPEDFWKPE 846
Query: 488 QKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRD 547
+ L T E+ L EPL + D F + E+ + ++ F D
Sbjct: 847 SQLVTILTATELKMT----EMPGRLNIIEPLLSTVSSIEFDAVAFPKNEQFRILLFFFHD 902
Query: 548 LFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKA 605
L + +F+I T+ RF ++ + Y VP+HNF+H V Y I+K V F
Sbjct: 903 LGLLKEFNIQIETILRFITSISEQYHHVPFHNFNHAVDVTQMAYMIVK--VGRLFSNFTK 960
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHN 664
LAL V+ +CHD+ HRG S+ +PL+ ++ +E H + + + + N
Sbjct: 961 LEILALLVSAICHDMGHRGKMGT-SSKVQTPLSLLFKDQPVMETFHCSSAIKTIGKPSCN 1019
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
I S ++++ + + IL+T+ + +D + + DE + R M
Sbjct: 1020 ILSSLNADQLHDFWVLVIDTILSTETSQHQKIIDDAKLSFAPDET-LPLANTQQRARMMK 1078
Query: 725 ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQV 784
+ + +L++ A+P++ V+ +EF D D E A P+E
Sbjct: 1079 LILRIGNLASCARPFDSTKSWSSVLSDEFTD--DSENAG---------EKTPQEIARWNA 1127
Query: 785 GFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
L I P +++L + +P K + +N+ +W+ A+
Sbjct: 1128 DHLKAIAAPAFELLSKAVPLLKGIGKQFKRNVEKWEEIAN 1167
Score = 123 bits (297), Expect = 2e-26
Identities = 74/183 (40%), Positives = 105/183 (57%), Gaps = 12/183 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL V + + E+ + LI++++ AQ +NADR SLFLVD L S V
Sbjct: 519 LLAVAQELSAEL-DTNALIRKVMTKAQSFINADRCSLFLVDKVRGGLWSVV--------- 568
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
E +I +P+ GIAG VA +GE +NIPDAYSD RFN VD+ TGY T SILC+PI+
Sbjct: 569 -AHGENSKIFVPLGEGIAGTVAKTGEIINIPDAYSDPRFNPAVDKKTGYLTKSILCVPIR 627
Query: 436 -VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
+G ++G QM+NK D F D F+ F G+AL +A+LY+ ++K L
Sbjct: 628 NNDGSIMGCTQMINKLDGNEFTKTDIELMSAFNVFCGIALSNAQLYESATITKKKMSAIL 687
Query: 495 EVL 497
+++
Sbjct: 688 DIV 690
Score = 53.6 bits (123), Expect = 2e-05
Identities = 52/181 (28%), Positives = 82/181 (45%), Gaps = 10/181 (5%)
Query: 316 LLDVVKAIF-EEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPG 374
L D K++ + V L L++ I R++ + +F D +++ LV + + G
Sbjct: 335 LTDTTKSLLIDRQVML--LLESIQLTTSRVIGCEVLQVFFADEKDNSLVQ-LREAARSKG 391
Query: 375 LDLDMEKK--EIRMPINR-GIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILC 431
D D I+ PI+ GIAG + + +NIP A FN +D Y S+L
Sbjct: 392 SDDDSLSSVTRIKTPIDSAGIAGTCYKTKQIINIPIAKERVDFNMTMDGE--YPNGSLLA 449
Query: 432 MPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKY 490
MP+K G V+ V KR F DE E S + AL +A+L++ ++ QK
Sbjct: 450 MPLKSSNGTVMLVAVARQKRSGMMFNKTDEIMLEALSRVYSSALQNAQLHESNIQNIQKA 509
Query: 491 R 491
R
Sbjct: 510 R 510
>UniRef50_UPI00015B464B Cluster: PREDICTED: similar to
ENSANGP00000010843; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010843 - Nasonia
vitripennis
Length = 801
Score = 144 bits (348), Expect = 1e-32
Identities = 89/280 (31%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDI--TTLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D ++++ E + +MF +L +F+I +TL F V NY VP+HNF H + VA
Sbjct: 497 DARQWEDEELLLMLQTMFFELELPQKFNIPLSTLRNFIYEVYNNYNEVPFHNFRHCFCVA 556
Query: 586 HAMYAILKS-DVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
+Y I S + K R + L L V+C+CHDLDH GY N Y + LA Y
Sbjct: 557 QMLYIITGSVNTKSRIGDLEV---LVLIVSCICHDLDHPGYNNIYQINARTELALRYNDI 613
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH ++ IL+ NI + + E Y+ + I CILATD+A ++I
Sbjct: 614 SPLENHHCSVAFHILEAPECNILASLQPETYRIVREGIIRCILATDMARH----NEILAQ 669
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + H +L + + AD+S A+P ++ + + +EF+ Q D E+
Sbjct: 670 FTDAVPDFDYSSKVHINLLSMVLIKVADISNEARPMDVAEPWLDSLLQEFFKQSDAEKLE 729
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K +P+SQ F+ + +P +++L + P
Sbjct: 730 GLPVTPFMDRDK-VTKPSSQCSFIGLVLLPLFEILGELFP 768
>UniRef50_A2DJF3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1006
Score = 142 bits (344), Expect = 4e-32
Identities = 88/303 (29%), Positives = 145/303 (47%), Gaps = 11/303 (3%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D R+D + + + + QF + T F + +Y VPYHN+ H V
Sbjct: 707 DAQRWDGIGHLRVVFYLMNYFGVLKQFKVRNDTFLHFLDEISNSYNKVPYHNWRHAVDVT 766
Query: 586 HAM-YAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
+ Y ++ S V + K AL +A +CHD++H G+TN Y + +PL ++
Sbjct: 767 QFVSYQLVVSGV---YKILKPIELYALLIAAICHDVNHDGFTNVYNEKAETPLGILFKNQ 823
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S +E HH + + ++ D NIFS S K+I I IL TD+ L+ I +
Sbjct: 824 SVMETHHCQVAIQVVSNDKCNIFSSFDSPLIKQIWSLIIALILKTDMGKHHSTLEAINK- 882
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
R DE D+ R + M + + +D+S ++P+E+ K V+ EEF+ QGD E+ +
Sbjct: 883 -RLDEGPLKPDNEQDRFMMMELILKCSDISNVSRPFELADKWCDVLCEEFFRQGDLEKTS 941
Query: 764 G-RIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKAR 822
G P+ DR ++P SQ+GF + +C+P + R +P + NL WK+
Sbjct: 942 GMEYTSPLNDR-AHLDKPKSQIGFYTFVCLPLFVTAARAMPALQVNVDQVNSNLAIWKSH 1000
Query: 823 ADK 825
D+
Sbjct: 1001 HDQ 1003
Score = 117 bits (281), Expect = 2e-24
Identities = 70/167 (41%), Positives = 101/167 (60%), Gaps = 12/167 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL V + IF ++ LD L+ I++ A L+N +R SLF++D +ELV+ +F GL
Sbjct: 324 LLAVAEVIFG-VLDLDSLLPTIMDTACNLLNTERCSLFILDKTTNELVT-----RFHGGL 377
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
D IR+ GIAG+ A SGE +NI DAYSD RF++ D TG+KT S+L +PI
Sbjct: 378 DT-----AIRVKNGVGIAGYTASSGECVNITDAYSDSRFDKTSDIQTGFKTRSLLTVPIY 432
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYD 481
G V GV +M+N++D K F DDD F+ F G+++ +A LY+
Sbjct: 433 DNRGAVAGVTEMINRKDGKSFDDDDIKMMVAFNVFCGISIDNANLYN 479
>UniRef50_Q9VYJ0 Cluster: CG32648-PA; n=3; Coelomata|Rep: CG32648-PA
- Drosophila melanogaster (Fruit fly)
Length = 963
Score = 142 bits (343), Expect = 5e-32
Identities = 89/280 (31%), Positives = 144/280 (51%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + + + + + +MF +L + +F I TL + V K+Y VP+HNF H + VA
Sbjct: 61 DSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVA 120
Query: 586 HAMYAILK-SDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-T 643
MYAI + +++ R + L L V+C+CHDLDH GY N Y + LA Y
Sbjct: 121 QMMYAITRQANLLSRLGDLEC---LILLVSCICHDLDHPGYNNIYQINARTELALRYNDI 177
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH +I +L+ NIF + S + + I I CILATD+A L + E+
Sbjct: 178 SPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI 237
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
F + + +H +L I + AD+S A+P ++ + + +EF+ Q E++
Sbjct: 238 ----TPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSE 293
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MD +K +P SQV F+ + +P ++ L ++P
Sbjct: 294 GLPVTPFMDPDK-VSKPGSQVRFIGLVLLPLFEALGELVP 332
>UniRef50_A2DNV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1023
Score = 142 bits (343), Expect = 5e-32
Identities = 146/604 (24%), Positives = 260/604 (43%), Gaps = 47/604 (7%)
Query: 253 ILYQPIITKSGKTSYVLEMWRTKD-RFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERN 311
IL PI +G+ + V +M KD F D +I V+ ++L KL+ N
Sbjct: 434 ILGVPIYNSNGEVTGVTQMINKKDGNFIEDDIKIMKCFNVFCGISLDNVKLF---NVSTN 490
Query: 312 MSDFLLDVVKAI--FEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSEL-VSTVFD 368
+++ L V+A F + + + L++ +LE A + A RA++ D E V +
Sbjct: 491 LANHLKKFVEAADTFTKSENKNALVE-LLESAADICQASRATMLSYDVDTKEFQVLANYG 549
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
F+ + E E P + G ++I Y D + DE T S
Sbjct: 550 HNFDGSYERAQEVVEYATP---QVFGERQPGKIKLHI-SGYFDNNTSNGPDE-TLLNAAS 604
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDK--YFG----DDDEAAFEI--FSTFFGLALHHARLY 480
L + E ++V + ++K FG D I F T L H +L
Sbjct: 605 RLSQAFEAEAIKSPPPEIVEEHNEKPQIFGFPLTSQDRVVIGIVEFETKLPLTTEHIKLL 664
Query: 481 DRI-------MRKEQKYRVALE---VLSYHNTCREYEVQA------MLLDKEPLNVDFAD 524
+ + ++Q ++A ++ H + E ++LD+E F
Sbjct: 665 ESYCTFASMAIERDQLQKIAKSSQLLIHEHQFMKNEEKDKFTTPANLVLDEESEKQVFT- 723
Query: 525 FYLDPFRFDEFEKCKCIISMFRDLFDMTQFDITTLTRFT-LT-VKKNYRTVPYHNFDHGW 582
D +FD F + + ++F + +F++T F+ LT V ++Y VPYHN H
Sbjct: 724 LGFDAQKFDGFSHYRVMWAIFTRFDLLREFNVTNEKFFSFLTEVSESYNKVPYHNRRHAV 783
Query: 583 TVAHAM-YAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY 641
V + Y I+ + + + L +AC+CHD++H G+TN Y + +PL ++
Sbjct: 784 DVTQFVAYEIIIGKIDKILTKEEL---FCLLIACICHDINHDGFTNVYNVKAETPLGILF 840
Query: 642 -TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKI 700
S +E HH +T+ I+ + N+F+ + Y ++ + IL TD+ + + +
Sbjct: 841 KNQSVMETHHCEVTIGIMTNEMSNVFACFEGQQYSKMWQMLFTLILGTDMFHHYTIIKQF 900
Query: 701 RELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKE 760
EL D+ + D +R M I + D+S ++P++I K V+ EEF+ QGD E
Sbjct: 901 NELL--DKGPLDYSDDQNRLKLMQILLKCGDISNVSRPFKIADKWCDVLCEEFFRQGDLE 958
Query: 761 RAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+A G ++ ++P SQ+GF +C+P +++ R +P NL W+
Sbjct: 959 QAQGMEYTSNLNDRAHLDKPKSQIGFYKFVCLPLFEVAERAIPELGVNKQSILINLKEWE 1018
Query: 821 ARAD 824
+ D
Sbjct: 1019 RQLD 1022
Score = 116 bits (278), Expect = 4e-24
Identities = 80/234 (34%), Positives = 132/234 (56%), Gaps = 20/234 (8%)
Query: 251 NYILYQPIITKSGKTSYVLEMWRTKDRF--KVIDEEISGHIVVWGSVALHYCKLYVDKKR 308
N + P++ K G+ ++ +R +D+F K I ++ ++ V +Y L +
Sbjct: 270 NSVFAHPLLMK-GRNGCIV--FRRQDKFTHKDIRRILAICPIIGTCVERNYGHLSISAMN 326
Query: 309 ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFD 368
R + LLD+ ++I M L LI I+E A L+ +R SLF+VD +E+ ST
Sbjct: 327 NRLSA--LLDIAESI-GPMTDLRTLITMIMERACSLIGTERCSLFMVDRVKNEIYST--- 380
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
F GLD EIR+P++RGI G+ A +G+ +NI +AY+D RF+ VD TG++T +
Sbjct: 381 --FNQGLD-----SEIRIPMSRGIVGYTARTGQIVNITNAYNDPRFDNSVDIETGFRTRN 433
Query: 429 ILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYD 481
IL +PI G+V GV QM+NK+D + +DD + F+ F G++L + +L++
Sbjct: 434 ILGVPIYNSNGEVTGVTQMINKKDGNFI-EDDIKIMKCFNVFCGISLDNVKLFN 486
>UniRef50_A2ERL4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1180
Score = 141 bits (342), Expect = 7e-32
Identities = 83/316 (26%), Positives = 154/316 (48%), Gaps = 9/316 (2%)
Query: 511 MLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFR--DLFDMTQFDITTLTRFTLTVKK 568
+++ ++ L + + +D K + ++F D F + + RF ++
Sbjct: 746 LIIPEDVLKNNVFTIKFNSLEWDGIGHFKVLFAIFHYFDFFQIYKITNEKFFRFLYAIRS 805
Query: 569 NYRTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTN 627
Y+ VPYHN+ H V + Y I+ S +++ F + S L VA +CHD +H G+TN
Sbjct: 806 MYKKVPYHNWRHAVDVTQFVTYQIMISGLEKVFTKFELFS---LVVAAICHDANHDGFTN 862
Query: 628 KYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
Y + +PL +Y S +E HH +I + I+ + N+ + ++ ++Y EI I IL
Sbjct: 863 IYNVKAETPLGILYKNQSVMETHHCSIAIQIMSHEETNLLAALNQDEYIEIWSLIIQYIL 922
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATD+A F L + ++Y D F+ HR + + + + D+S ++P+E+ +
Sbjct: 923 ATDMARHFEILKRFNDIY--DGGDFTMQRHDHRVMLLYMILKCGDISNVSRPFELADRWC 980
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
V+ EEF+ QGD E+A G ++ ++ SQ+GF + + +P + + +P
Sbjct: 981 DVLCEEFFRQGDLEQAQGMAYTSDLNDRSHLDKAKSQIGFYTYVTLPMFQAAGKAVPALD 1040
Query: 807 PMYAMATKNLNRWKAR 822
NL+ WK +
Sbjct: 1041 VNMRQVLSNLSVWKRK 1056
Score = 118 bits (284), Expect = 7e-25
Identities = 67/184 (36%), Positives = 110/184 (59%), Gaps = 12/184 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL++ + ++ +D LI I+ A L+NA R SLFL+D R + +++T +F G+
Sbjct: 355 LLEIAMTLSGQL-DIDNLIPMIMSRACSLLNAQRCSLFLID-RATNMLTT----RFANGV 408
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
D K +++PI +GI G A +G +NIPDAYSD RFN+ +D TG++T +IL +PI
Sbjct: 409 D-----KGLQIPITQGIVGQTATTGAILNIPDAYSDPRFNKQIDIETGFRTNTILSVPIV 463
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
G++IGV +M+NK+ F D+D F+ F G++L +A+LY + ++ +
Sbjct: 464 NNRGEIIGVTEMINKKSGLLFDDEDIRMMTAFNVFCGISLDNAKLYQASLDLSKQLTIFT 523
Query: 495 EVLS 498
E+ S
Sbjct: 524 EMSS 527
>UniRef50_Q8I6Y6 Cluster: CGMP-specific phosphodiesterase; n=3;
Dictyostelium discoideum|Rep: CGMP-specific
phosphodiesterase - Dictyostelium discoideum (Slime
mold)
Length = 522
Score = 137 bits (332), Expect = 1e-30
Identities = 75/265 (28%), Positives = 134/265 (50%), Gaps = 9/265 (3%)
Query: 557 TTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACL 616
+++ F V +YR P+H+F+H V ++ IL F+ +L++ +A +
Sbjct: 250 SSILNFLSIVASSYRNNPFHSFNHAIAVTQTIFLILLKT--NLFNILSPIEKLSIIIASI 307
Query: 617 CHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQD-GHNIFSHISSEDY 674
CHDLDH +N++ S +A +Y S LE+HH +I + IL+ G+ + S ++ E+
Sbjct: 308 CHDLDHPALSNRFQINMKSSIAVLYNNKSVLENHHLSICLGILESKIGNELLSTLTVEEK 367
Query: 675 KEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSA 734
K+ ++ ILATD+ F + ++ + FSWD+ HRDL + + + +AD+S
Sbjct: 368 KQFFRRVKILILATDMENHFTYKKQFDDIIST----FSWDNSEHRDLLLIMFLKSADISN 423
Query: 735 SAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPC 794
+ ++I K + EEF++Q D E+ P M+R K +QV F+ + +P
Sbjct: 424 ELRSFDISNKWANALMEEFFNQSDLEKLNNLPLTPFMEREKVVLH-LTQVSFIEKFLLPS 482
Query: 795 YDMLYRILPNTKPMYAMATKNLNRW 819
Y L +LP+ + +N W
Sbjct: 483 YQSLQNLLPSLEDFVQRIIENKEIW 507
>UniRef50_A2DM77 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1072
Score = 136 bits (330), Expect = 2e-30
Identities = 137/586 (23%), Positives = 258/586 (44%), Gaps = 36/586 (6%)
Query: 244 NSRNKQGNYILYQPIITKSGKTSYVLEMWRTKDRFKVIDEEIS---GHIVVWGSVALHYC 300
N N + +L PI + V+++ KD +++I+ + V+G V+ ++
Sbjct: 505 NMMNFKTLSVLSIPIFDQRKNVIGVVQLLNRKDNRPFSNDDINIATSFLSVYGVVSDNWF 564
Query: 301 KLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
LY ++ + ++ V + +L +++ IL+ + +NA+R +++ D
Sbjct: 565 -LYKQEQTTEGRNTIIMRSVSRVSRGSTNLPEVLNGILQEVKAELNAERFYVYVKD---- 619
Query: 361 ELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDE 420
E L+L E +P + A +S T DA +D F+ +D
Sbjct: 620 ---------NIEDHLNLFTTDVEENVPPHIPKATLPNISRITN---DAQNDKMFSAILDN 667
Query: 421 ATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
AT KT S + P+ +++GK IGV+Q+ N F D ++ + L
Sbjct: 668 ATNTKTNSFISTPMYRLDGKFIGVIQICNAPHG--FDIKDLRLLQVIGAICTHPIEVKDL 725
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
++ E + ++ + +S E+ + ML+ + + + + + +D K
Sbjct: 726 SQEAVKGEMQTTMS-KFIS-ETEMNEFSIPHMLVYSKQEDTEANNLEFASYMWDYDTTFK 783
Query: 540 CIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVK 597
+ ++F M +F IT TL F + ++ VP+HNF + ++
Sbjct: 784 VVFAVFNQFNLMKKFQITASTLFNFIFEARSEFQIVPFHNFYLAIDQLQFLNILINEGNL 843
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTI 657
ER + + LAL +A LCHD+ H G NKY+ ET SP+ A + E+HHF I + +
Sbjct: 844 ERI--LQPTEFLALIIATLCHDMGHDGVDNKYLRETNSPIFAAFPEYPNENHHFVILIEV 901
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDDP 716
+++ G +F++I+ +D I G IR IL+++ L K E+ + +P
Sbjct: 902 IKRSG--LFNNINLQDTTAIWGVIRDLILSSNCDP--KELQKETNEIVMNGPPDM--QNP 955
Query: 717 SHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKP 776
R + M + + D S S + W++ K +F E + QGD G P R KP
Sbjct: 956 RTRKVLMRLLVNICDWSYSMRSWDVCDKWSFNLFAEHFMQGDLMTELGLKPDEHYLRGKP 1015
Query: 777 EEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKAR 822
E+ V + + I ++ +I+P+ + + A +N++R K R
Sbjct: 1016 VEKQKETVWCIEEELIRLTTLISKIVPDFQFLEVAALRNIDRRKER 1061
Score = 70.5 bits (165), Expect = 2e-10
Identities = 47/167 (28%), Positives = 87/167 (52%), Gaps = 6/167 (3%)
Query: 338 LEFAQRLVN-ADRASLFLVDYRNSELVST---VFDLKFEPG-LDLDMEKKEIRMPINRGI 392
+E A++L +D+ + +++D S+ +T + E G L ++ K M + GI
Sbjct: 418 IEVAEKLRGPSDKLTSYVIDQIQSQCCATKVILLQCDNERGQLYTFVDGKRFEMTMRSGI 477
Query: 393 AGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGK-VIGVVQMVNKRD 451
AG L+G+ NI + D F+ D +KT+S+L +PI + K VIGVVQ++N++D
Sbjct: 478 AGKTYLTGQVYNIGNVLDDPEFDSSFDNMMNFKTLSVLSIPIFDQRKNVIGVVQLLNRKD 537
Query: 452 DKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS 498
++ F +DD F + +G+ + LY + E + + + +S
Sbjct: 538 NRPFSNDDINIATSFLSVYGVVSDNWFLYKQEQTTEGRNTIIMRSVS 584
>UniRef50_Q23917 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase
regA; n=2; Dictyostelium discoideum|Rep:
3',5'-cyclic-nucleotide phosphodiesterase regA -
Dictyostelium discoideum (Slime mold)
Length = 793
Score = 131 bits (316), Expect = 1e-28
Identities = 79/298 (26%), Positives = 137/298 (45%), Gaps = 9/298 (3%)
Query: 528 DPFRFDEFEKCKCIISMFRD--LFDMTQFDITTLTRFTLTVKKNYR-TVPYHNFDHGWTV 584
D F++ E + ++ MF + L ++ + I L RF +TV YR YHNF H + V
Sbjct: 436 DVFKYSEDDLMPLLVDMFENFQLPEIFKIPIEKLQRFIMTVNALYRKNNRYHNFTHAFDV 495
Query: 585 AHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
+Y L S Y AL ++C+CHDL+H G+ N + + L+ Y
Sbjct: 496 TQTVYTFLTSF--NAAQYLTHLDIFALLISCMCHDLNHPGFNNTFQVNAQTELSLEYNDI 553
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH +T IL+ NI ++ + YKE+ + ILATD+ F + +K +
Sbjct: 554 SVLENHHAMLTFKILRNSECNILEGLNEDQYKELRRSVVQLILATDMQNHFEHTNKFQ-- 611
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ + F + R + + + D+S A+PW + + + +EF+ Q E
Sbjct: 612 HHLNNLPFDRNKKEDRQMILNFLIKCGDISNIARPWHLNFEWSLRVSDEFFQQSHYETIC 671
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKA 821
G P MD+ K + F+ + P + + + L ++ + + +KN W+A
Sbjct: 672 GYPVTPFMDKTKTTRARIA-ADFIDFVASPLFQSMAKFLKESQFLLKVISKNRENWQA 728
>UniRef50_A4RV03 Cluster: Predicted protein; n=1; Ostreococcus
lucimarinus CCE9901|Rep: Predicted protein -
Ostreococcus lucimarinus CCE9901
Length = 401
Score = 127 bits (307), Expect = 1e-27
Identities = 85/272 (31%), Positives = 126/272 (46%), Gaps = 12/272 (4%)
Query: 541 IISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
++ MF ++ D RF V+ YR PYH F H V H Y + + VKE+
Sbjct: 36 VVRMFHEMNMFELVDQFKFRRFLSEVEGMYRDNPYHCFKHAVDVTHTTYLYICA-VKEQV 94
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQ 659
+ +L VA L HDLDH G TN Y+ T +A Y S LE+ H + ++ Q
Sbjct: 95 SMTQVEI-FSLLVAALVHDLDHPGVTNGYLIATHDNIALTYNDESVLENLHLSRFFSLCQ 153
Query: 660 Q-DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDE-------AQF 711
+ NI S YKEI I C+L TD+A F + ++ EL + +
Sbjct: 154 NNEDANILSAFDESTYKEIRRSIISCVLHTDMAHHFKLVSRLNELVALGKKNNIINGSPM 213
Query: 712 SWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM 771
R L + + + AD+S + KP E+ +K + EEF++QGD+ER+ G PMM
Sbjct: 214 KSTTDDERQLMLNVLLHCADISNAVKPNELCVKWASRVLEEFFNQGDRERSRGMSISPMM 273
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
DR + SQ+ F+ + P Y + P
Sbjct: 274 DR-ETTSVGLSQINFIEFVIAPLYVQFVAVFP 304
>UniRef50_A0EHP5 Cluster: Chromosome undetermined scaffold_97, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_97,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 908
Score = 127 bits (307), Expect = 1e-27
Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 10/259 (3%)
Query: 549 FDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
FD Q T +F + +++ Y R P+HNF+HG+TVAHA Y ++K+ + + +Y +
Sbjct: 636 FDKYQMYKETFFQFLVAIEERYNSRRNPFHNFEHGFTVAHACYYMIKNKLLD--EYLDQT 693
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNI 665
+ A ++ LCHD+DH G TN + S LA Y S LE+HH + I+Q++ +NI
Sbjct: 694 EQFAAILSSLCHDIDHTGRTNGFEVARMSKLAVRYNDESVLENHHAAMAFKIMQREKYNI 753
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
S++S E ++++ F+ ILATD+ F + + Y++ E D + R L+ I
Sbjct: 754 LSNLSQEQFQKVRRFMVSNILATDMKKHFDLVSSLEIKYKNGEMNIVNMD-TKRVLSGLI 812
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVG 785
T DL+ K +EI K I EF +Q ++ER G +P+ + P ++
Sbjct: 813 VHT-CDLTQPTKRFEITKKWSIRIQNEFDNQVEEERLLG---LPITQHLVCQNLPKQELS 868
Query: 786 FLSQICIPCYDMLYRILPN 804
F+ I P Y + IL N
Sbjct: 869 FIRNIIQPLYALTSSILNN 887
>UniRef50_Q23AZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Tetrahymena thermophila SB210|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Tetrahymena thermophila SB210
Length = 577
Score = 126 bits (304), Expect = 3e-27
Identities = 70/275 (25%), Positives = 131/275 (47%), Gaps = 6/275 (2%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
+L D + D ++ ++ YR PYH+ H + V ++ + K+
Sbjct: 282 NLLDDLKIDSQKFINLSVRIQNGYRDNPYHDRLHSFDVTQTIHFFISRCKFGELAKLKSM 341
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFN-ITVTILQQDGHN 664
R A++ + HD DH GY N ++ T + LA + S LE+HH + + IL+ N
Sbjct: 342 ERAAMYFSAAIHDFDHPGYNNVFLINTQNILALKFNDQSVLENHHVSSVYEMILKNHNLN 401
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
IFS+ S+++YK+ + + +LATD+ F ++ K++ + + + D + M
Sbjct: 402 IFSNFSNDEYKQFREMVVNMVLATDMTKHFADISKLKSRIAATDFEI---DGKDKKTVME 458
Query: 725 ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQV 784
+ A+D+S A+PWEI + + EF+ QGD+E+ G +P+ + SQ
Sbjct: 459 SLLHASDISNPARPWEICYQWTNKVMTEFWAQGDEEKRLG-LPVTYLCDRVETNTSKSQQ 517
Query: 785 GFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
GF+ + P ++++ LP + +N +W
Sbjct: 518 GFIDFVVKPLFEIISNFLPELQQFMINFEQNKEKW 552
>UniRef50_A5JZK2 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
phosphodiesterase, putative - Plasmodium vivax
Length = 1164
Score = 126 bits (304), Expect = 3e-27
Identities = 76/247 (30%), Positives = 127/247 (51%), Gaps = 10/247 (4%)
Query: 556 ITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVAC 615
+ ++ F V+K Y VPYHN H V + + K +D+ + +L +F++
Sbjct: 852 MNSIINFLSFVEKQYNNVPYHNTIHATMVTQKFFCLSKK--LGIYDHMEYKIKLVMFISG 909
Query: 616 LCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDY 674
+CHD+ H GY N + + PL+ +Y S LE++H +IT ILQ + N+ S +D+
Sbjct: 910 ICHDVGHPGYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQLNQCNLLKSFSEKDF 969
Query: 675 KEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM--TAADL 732
+ I +I IL+TD+ F + K R R + F + ++ DL + I M +AD+
Sbjct: 970 RLIRSYIIELILSTDMKYHFEIISKFR--IRRENEDFDY-VKNNDDLLVLIKMIIKSADI 1026
Query: 733 SASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQIC 791
S + W K + + EFY QGD+E ++P+ P+ DR K E SQ+ FL +
Sbjct: 1027 SHGSVKWNEHYKWCQRVLCEFYSQGDEE-LKNKMPLSPLCDRTKHNEVCQSQITFLKFVV 1085
Query: 792 IPCYDML 798
+P ++ L
Sbjct: 1086 MPLFEEL 1092
>UniRef50_UPI0000E47CF4 Cluster: PREDICTED: similar to camp/cgmp
cyclic nucleotide phosphodiesterase; n=1;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
camp/cgmp cyclic nucleotide phosphodiesterase -
Strongylocentrotus purpuratus
Length = 398
Score = 124 bits (300), Expect = 8e-27
Identities = 76/189 (40%), Positives = 116/189 (61%), Gaps = 11/189 (5%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE---LVSTVFDLKFE 372
L+++VK I E+ L L +IL+ L ADR SLFLV + +E L + +FD+ +
Sbjct: 153 LIELVKDIANEL-ELSMLCHKILQNVLILTKADRGSLFLVRGKGTEQCCLATKLFDVTIQ 211
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
++ ++EI +P +GI G+VA +GET+NI +AY D RFN ++D TGYKT S+L M
Sbjct: 212 S--TVEQTREEICVPWRKGIVGYVAETGETVNIANAYEDPRFNCEIDLRTGYKTRSMLSM 269
Query: 433 PIKVE-GKVIGVVQMVNKRDDK----YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKE 487
PIK G+V+GV Q++NK K F D DE F + F G+ +++ARLY+R +
Sbjct: 270 PIKEPGGEVLGVAQVINKIGSKDQHEAFTDSDEKVFAQYLQFCGIGINNARLYERATLEI 329
Query: 488 QKYRVALEV 496
++ +V LE+
Sbjct: 330 RRNQVLLEL 338
Score = 47.2 bits (107), Expect = 0.002
Identities = 22/97 (22%), Positives = 50/97 (51%)
Query: 276 DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIK 335
+ F DE++ + + + ++ +LY E + LL++ K +FEE +L +++
Sbjct: 295 EAFTDSDEKVFAQYLQFCGIGINNARLYERATLEIRRNQVLLELAKTLFEEQSTLSSIVR 354
Query: 336 RILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFE 372
RI+E L+ +R S+ +VD + + + L+++
Sbjct: 355 RIMELLLSLLRCERCSILMVDESSKVGMMEINSLEYQ 391
>UniRef50_UPI000065E700 Cluster: Cone cGMP-specific 3',5'-cyclic
phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP
phosphodiesterase 6C).; n=1; Takifugu rubripes|Rep: Cone
cGMP-specific 3',5'-cyclic phosphodiesterase subunit
alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C). -
Takifugu rubripes
Length = 937
Score = 123 bits (296), Expect = 3e-26
Identities = 62/187 (33%), Positives = 103/187 (55%), Gaps = 5/187 (2%)
Query: 525 FYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGW 582
F F EF+ K I MF +L + +F + TLTR+ TV+K YR + YHN+ HG+
Sbjct: 588 FAFSDFPVSEFDLIKAGIRMFFELGVVEKFKVPAETLTRWMYTVRKGYRAITYHNWRHGF 647
Query: 583 TVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE-TASPLAAMY 641
V H M+ +L++ ++ Y+ + A+ A CHD+DHRG N Y ++ +A PLA ++
Sbjct: 648 NVGHTMFCLLQTGKLRKY-YSDLDA-FAMVAAAFCHDIDHRGTNNLYQTKRSAHPLAKLH 705
Query: 642 TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIR 701
TS +E HH + T++ ++ NIF ++ ++ + CI+ATDLA +F +
Sbjct: 706 GTSIMERHHLEYSKTLMGEEVLNIFCNLQKRQFEHVQHLFDVCIIATDLALYFKKRTMFQ 765
Query: 702 ELYRSDE 708
+ + E
Sbjct: 766 NIVNATE 772
Score = 83.4 bits (197), Expect = 3e-14
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 9/159 (5%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNS--ELVSTVFDL----KFEPGLDLDMEKK 382
+++Q + ++L+ ++ ADR S F RN EL + +FD+ KFE +L +
Sbjct: 68 NMEQCLHKVLQRVGLIIQADRLSYFQCRGRNGTPELTTCLFDVTPTSKFEA--NLVHPQT 125
Query: 383 EIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIG 442
EI P+ GI GH A S + N+PD + +F+ VD+ TGYKT +L P+ V+ + IG
Sbjct: 126 EIVFPLEMGIVGHTAQSKKPQNVPDVSASKKFSDFVDKQTGYKTKCMLAYPMVVDKECIG 185
Query: 443 VVQMVNKRDDKYFGDDDEAAFEIFSTFFG-LALHHARLY 480
VV +NK F +D+ F+ + F + L H Y
Sbjct: 186 VVMALNKIGADAFTAEDDQLFQKYMNFAQVITLQHHTAY 224
Score = 82.6 bits (195), Expect = 4e-14
Identities = 41/101 (40%), Positives = 55/101 (54%), Gaps = 1/101 (0%)
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMDRNKPEEQPAS 782
A+ MT DLSA KPWE+Q K ++ EF++QGD ER+ + PIPMMDRN E+ P
Sbjct: 823 AMMMTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLERSVLDQQPIPMMDRNCAEQLPKM 882
Query: 783 QVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARA 823
Q GF+ +C Y R +PM+ N + W A
Sbjct: 883 QCGFIDFVCSFVYKEFSRFHKEIQPMFDGLNNNRSHWNELA 923
Score = 72.1 bits (169), Expect = 6e-11
Identities = 37/130 (28%), Positives = 71/130 (54%), Gaps = 3/130 (2%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ + +D + F ++ + TG+ ++L +PI + +++G+
Sbjct: 368 GLPTYVAENGFICNMMNVAADDFFAFQKEAVDETGFIIKNVLSLPIVNKKEEIVGIATFF 427
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YDR+ R E + +A E+L Y C E
Sbjct: 428 NRKDGKPFDEHDEQITEALTQFLGWSVLNCDTYDRLNRMEHRKDIAQEMLMYQTKCTSDE 487
Query: 508 VQAMLLDKEP 517
+Q++L+ EP
Sbjct: 488 LQSILVSTEP 497
>UniRef50_A2EAR4 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1209
Score = 123 bits (296), Expect = 3e-26
Identities = 71/171 (41%), Positives = 98/171 (57%), Gaps = 11/171 (6%)
Query: 327 MVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRM 386
++ D L+++I+ AQ + ADR SLFLVD L S V E I +
Sbjct: 570 VLDTDTLVRKIMTKAQSFIGADRCSLFLVDKERGGLWSMVAHGTSE----------RIHI 619
Query: 387 PINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQ 445
GIAGHVA +GET+NIPDAY+D RFN VD++TGY+T SILC+PIK G +IG Q
Sbjct: 620 AEGYGIAGHVAKTGETINIPDAYNDPRFNPSVDKSTGYRTKSILCVPIKSSSGIIIGCTQ 679
Query: 446 MVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEV 496
M+NK F D F+ F G+AL +A+LY+ + ++K L++
Sbjct: 680 MINKLGAVEFSRTDVELMTAFNVFCGIALSNAQLYEAATKSKKKMTAMLDI 730
Score = 109 bits (261), Expect = 4e-22
Identities = 144/631 (22%), Positives = 271/631 (42%), Gaps = 72/631 (11%)
Query: 214 VAKKGTSKRV-SRFDDPLRFPETPLSLLRSCNSRNKQGNYILYQPIITKSGKTSYVLEMW 272
VAK G + + ++DP RF P S+ +S R K IL PI + SG +M
Sbjct: 629 VAKTGETINIPDAYNDP-RF--NP-SVDKSTGYRTKS---ILCVPIKSSSGIIIGCTQMI 681
Query: 273 RTKD--RFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSL 330
F D E+ V+ +AL +LY + + +LD+ ++ +L
Sbjct: 682 NKLGAVEFSRTDVELMTAFNVFCGIALSNAQLYEAATKSKKKMTAMLDIALSL-STSTTL 740
Query: 331 DQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINR 390
++LI I+ A+ L+ A+ LF VD +++L P ++ E KE I
Sbjct: 741 EELITSIISRARELIEAEHCFLFAVDRLHNKL---------RPLGNVGDEAKEFS--IKE 789
Query: 391 GIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNK 449
G+VAL+G +NI + ++ RF +D+ A K +L +P+ G+V+G+ + +NK
Sbjct: 790 DAVGYVALTGSEINIENVENEKRF-KDLWPAN-IKAKQMLVIPVLDASGQVVGIAKAINK 847
Query: 450 RDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQ 509
F +D++ FS+F GLA +DR + + Q L + T E+
Sbjct: 848 TTMPRFTSEDQSLLRAFSSFAGLA------FDRFIAR-QPAEFGLTDIPLIETLSPTELT 900
Query: 510 AML-LDK----EPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRF 562
A++ D+ +PL D + + E + +I +F ++ ++ F I RF
Sbjct: 901 AVVPSDRLRVFDPLTGIVGSLNFDVYSYPRNELYRFLIHIFTEMGLLSTFTIPIGVALRF 960
Query: 563 TLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDH 622
++ NY+ +P+H+F + + + ++ + K + K L+ FVA LCHDL H
Sbjct: 961 FSSIADNYQQLPFHDFANAVSTTQFAFWLMMLN-KLYIQFTKI-ELLSFFVAALCHDLGH 1018
Query: 623 RGYTNKYMSETASPLAAMYTTSTL-EHHHFNITVTILQQDGHNIFSHISSEDYKEILGFI 681
++ + L +Y + E H + +L Q NI ++ S +
Sbjct: 1019 SDRIT-VNAQVQAALDVLYKDQPVNETFHCAALIYLLAQPTCNILENLDSGYVNDFWTLC 1077
Query: 682 RHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSA------S 735
+L+ D + ++++ R + F + D + + L + + + +A +
Sbjct: 1078 IDLMLSLDPSQHAKLIEEMD--IRLNRGPFDFKDKAAKALLLKLMLKSAVTAEVFRPFDP 1135
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
KPW + + V+ +GD+ ++ + M + +L++ P
Sbjct: 1136 TKPWTTSVNKLSVV----ASKGDQ-----KVLLEEMTK------------YLNETSTPLV 1174
Query: 796 DMLYRILPNTKPMYAMATKNLNRWKARADKI 826
+L R + N +P+ N+N WK + DK+
Sbjct: 1175 RVLLRTMTNVQPLSDQLKLNMNGWKEQLDKL 1205
Score = 46.0 bits (104), Expect = 0.005
Identities = 48/236 (20%), Positives = 105/236 (44%), Gaps = 12/236 (5%)
Query: 253 ILYQPIITKSGKTSYVLEMW-RTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKR-ER 310
+LYQP++ + +V+++ R + V+ ++++ ++L ++Y D+ R +
Sbjct: 313 VLYQPVVNTKKEVLWVIQIVDRLSPKGTVVTPSGDDYLIL-DFLSLSLLRIYQDESRIDE 371
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
+ L + +++ E + L++ + LV + +F D + L + + K
Sbjct: 372 MIKRILTESTRSLLTERQVMP-LLETVQLTVTHLVGCESLQIFFADQQKGNLFQ-LCEGK 429
Query: 371 FEPGLDLDME---KKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTI 427
+ G ++++ + +I + GIAG +T+N+ A FNRD+D Y
Sbjct: 430 QQSGSEVNISAITRNDIAVD-QAGIAGVAYTQKKTVNVAVANEHPDFNRDIDGE--YPNG 486
Query: 428 SILCMPIKVEGKVIGVVQMV-NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR 482
L +P+ + +V + K++ F DE E S AL +A+ ++R
Sbjct: 487 PCLAVPLLGSKGTVSLVAVARQKKNGLMFTGSDEIILEALSRVSQGALANAQSHER 542
>UniRef50_Q090R6 Cluster: CGMP-dependent 3',5'-cyclic
phosphodiesterase; n=2; Cystobacterineae|Rep:
CGMP-dependent 3',5'-cyclic phosphodiesterase -
Stigmatella aurantiaca DW4/3-1
Length = 533
Score = 120 bits (290), Expect = 1e-25
Identities = 72/171 (42%), Positives = 99/171 (57%), Gaps = 12/171 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LLDV KA+ E LD L+ IL A ++V ADR SLF++D +EL S V
Sbjct: 52 LLDVAKAMSAER-DLDLLLPLILYEASKVVEADRCSLFIMDRERNELWSKV--------- 101
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
K EIR+P+ GIAG VA +G +NIPDAY+D RFNR D ++GY T +ILC+P++
Sbjct: 102 -AQGSKNEIRLPVGSGIAGQVASTGAVINIPDAYADERFNRSFDTSSGYHTQTILCVPMR 160
Query: 436 -VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
G V GV+Q +NKR+ + F +DE A+ +A L++ I R
Sbjct: 161 DASGDVTGVIQALNKRNGRIFDAEDEELLLALGANAAGAIENALLHEEINR 211
>UniRef50_UPI00015B4893 Cluster: PREDICTED: similar to camp-specific
3,5-cyclic phosphodiesterase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to camp-specific
3,5-cyclic phosphodiesterase - Nasonia vitripennis
Length = 1229
Score = 120 bits (289), Expect = 2e-25
Identities = 74/243 (30%), Positives = 116/243 (47%), Gaps = 10/243 (4%)
Query: 562 FTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSD-VKERFDYNKASSRLALFVACLCHDL 620
FTL + + T PYHN H V AM+ L+ + ++ Y + +A +A + HDL
Sbjct: 278 FTLIEEGYHSTNPYHNSIHAADVTQAMHCFLQEEQIRRHLSYLEI---MASLIAAVTHDL 334
Query: 621 DHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILG 679
DH G ++ T++ LAA+Y TS LE+HH+ V L + G + + E+
Sbjct: 335 DHPGVNQPFLVATSNHLAALYENTSVLENHHWRSAVGCLLESG--VSEQLPDRVKPELQR 392
Query: 680 FIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPW 739
I ILATD+ L + + DE + + P HR + I++ AD+S +PW
Sbjct: 393 HISSLILATDITRQQEFLTRFKRYL--DERELDMEQPEHRHFILQIALKCADISNPCRPW 450
Query: 740 EIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLY 799
+I K + EEF+ QGD ER +P+ + P Q GF + +P Y+ +
Sbjct: 451 DISRKWSYKVCEEFFRQGDYERQL-NLPVTALCDRHTTSIPKIQAGFFKFVVLPLYEEWH 509
Query: 800 RIL 802
R L
Sbjct: 510 RFL 512
>UniRef50_Q57V52 Cluster: 3', 5'-cyclic nucleotide
phosphodiesterase, putative; n=3; Trypanosoma|Rep: 3',
5'-cyclic nucleotide phosphodiesterase, putative -
Trypanosoma brucei
Length = 676
Score = 120 bits (288), Expect = 2e-25
Identities = 78/278 (28%), Positives = 132/278 (47%), Gaps = 10/278 (3%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILK-SDVKERFDYNKA 605
DL Q D TL RF L V+ Y PYHN H V Y I+ + +KER +
Sbjct: 402 DLVARFQLDDATLQRFLLGVQSGYHPNPYHNSMHAADVTQVNYYIIFIAGMKERCQL-RP 460
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHN 664
+L +A HD DH G N + + T + L+ +Y S LE+HH +L+ +N
Sbjct: 461 EEQLGAVLAAAVHDFDHPGLNNNFHTRTNAYLSTLYNDRSILENHHIASVFQLLKHPSYN 520
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
+ + ++ E ++ + + +LATD++ N I + ++S + S + +D+ +A
Sbjct: 521 VLAPLNDEQFRTVRETMVEMVLATDMS----NHGTILKRFQSRLVEASDWSANKQDVLVA 576
Query: 725 ISMT--AADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ-PA 781
+SM+ ADLS +P+ I + I +EFY QGD+E + P M+R ++ P
Sbjct: 577 LSMSIKTADLSNCIRPYYIYSEWSSYIAQEFYKQGDEEERSNLSISPFMNRKTSDKDFPE 636
Query: 782 SQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
Q F++ + P + + LP+ + + N W
Sbjct: 637 GQKSFITYVVAPMMEAVVMFLPHLRFTLQLCENNRTAW 674
>UniRef50_A0DIM1 Cluster: Chromosome undetermined scaffold_52, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_52,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 779
Score = 118 bits (285), Expect = 6e-25
Identities = 88/282 (31%), Positives = 145/282 (51%), Gaps = 17/282 (6%)
Query: 533 DEFEKCKCIISMFR--DLFDMTQFDITTLTRFTLTV--KKNYRTVPYHNFDHGWTVAHAM 588
D+ E+ + ++F + D+ Q + +FT+ V K +YR P+HN+DHG+TVAHA
Sbjct: 481 DKHEQLRYTWALFHLCNFIDLYQINKEVFYQFTVIVQEKYSYRQNPFHNYDHGFTVAHAC 540
Query: 589 YAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLE 647
Y I+KS ++ ++K AL ++ LCHD+DH G N + S+ S LA Y S LE
Sbjct: 541 YYIIKSKSMNQY-FDKFIQFTAL-LSALCHDIDHTGRNNHFESQKLSKLALRYNDESVLE 598
Query: 648 HHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS- 706
+HH ++ ILQ++ +NI S +S + + + IL TD+ F + K+ EL S
Sbjct: 599 NHHASVMFKILQKEKYNILSSLSQDQCQIFRKYAIANILGTDMKKHF-EIVKLLELKLSK 657
Query: 707 -DEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGR 765
+ F + + L+ AI T DL+ +K +++ K I EF DQ +E+
Sbjct: 658 LPDEPFIQKEEDKKFLSSAIVHT-CDLTMQSKTFKMAQKWSNRIATEFSDQVAEEKQLS- 715
Query: 766 IPI-----PMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL 802
+PI P+ N + ++ F+ I P YD+ ++L
Sbjct: 716 LPITQHFLPLGTPNFNQLLAKQEISFIKFIVKPAYDLTAQVL 757
>UniRef50_Q4KL87 Cluster: MGC116558 protein; n=2; Xenopus|Rep:
MGC116558 protein - Xenopus laevis (African clawed frog)
Length = 342
Score = 118 bits (284), Expect = 7e-25
Identities = 83/275 (30%), Positives = 133/275 (48%), Gaps = 14/275 (5%)
Query: 534 EFEKCKCIIS-MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYA 590
E ++ C++ MF +L +T+F + T+ F +V+K+Y+ P+HNF HG++V MY
Sbjct: 46 ERKQMLCLLEQMFYELDLVTEFKMEPETVRCFLTSVQKHYQENPFHNFYHGFSVTQMMYC 105
Query: 591 ILKS-DVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEH 648
++ ++E + L L VA LCHDLDH G +N Y + LA Y S LE+
Sbjct: 106 VISQCQLQEHLSHIDI---LTLMVAALCHDLDHPGLSNSYQVNAQTDLARQYHNKSPLEN 162
Query: 649 HHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDE 708
HH+ + IL Q N+ + I I ILATD+A L ++ +
Sbjct: 163 HHWAVAWRILSQKQSNLLLGADPKQVPHIQQEIMELILATDMAHHGEILQTLQNI----- 217
Query: 709 AQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI 768
F++ + H + D+S A+P E + EE++ Q D+E+ G
Sbjct: 218 ENFNFSNREHVTALKKGLIKICDISNEARPAEQAEIWADALMEEYFLQSDREKDEGLPVT 277
Query: 769 PMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
P MDR+K ++ A Q F+S + IP + L + P
Sbjct: 278 PYMDRDKVKKADA-QSSFISFLLIPLCEALCKHFP 311
>UniRef50_A4HHP3 Cluster: Putative uncharacterized protein; n=3;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania braziliensis
Length = 734
Score = 118 bits (284), Expect = 7e-25
Identities = 86/284 (30%), Positives = 128/284 (45%), Gaps = 10/284 (3%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
DL D L RF + V+ Y PYHN HG V Y I+ +
Sbjct: 433 DLVRYFNLDDAVLRRFLIAVQSAYHPNPYHNAMHGADVTQINYYIM---IVAGLSVKCCL 489
Query: 607 SRLALF---VACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
S +F +A HD DH G N + S T + LA +Y S LE+HH T +L+
Sbjct: 490 SNEEIFAGIIAGAVHDFDHPGLNNNFHSRTGAYLATLYNDRSILENHHLACTFELLRNPR 549
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
+NIF+ +S E + I +LATD+ + K ++ S+ ++ R LA
Sbjct: 550 YNIFATLSDEQRLLVRETILEMVLATDMGNH-ARIFKNFQVRMSEATEWHSKKEDVR-LA 607
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKP-EEQPA 781
+++S+ AD+S A+P I + K I +EFY QGD ER P MDR K E P
Sbjct: 608 LSMSIKMADISNCARPNHIYAEWAKNISKEFYLQGDAERKLNLSISPFMDRTKEMGEFPK 667
Query: 782 SQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
QV F+ I P + + +LP+ + N W+ + ++
Sbjct: 668 GQVSFMMYIVQPMVEAISALLPSMTFAVNLCVDNKEYWRRKTEE 711
>UniRef50_A2DVK5 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 771
Score = 117 bits (282), Expect = 1e-24
Identities = 71/188 (37%), Positives = 108/188 (57%), Gaps = 13/188 (6%)
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
+N LLDV K+I ++ + +LI I+ A LV ADR SLF+V+ +L ++
Sbjct: 416 QNRLKSLLDVAKSISCQL-DIRELIPMIMNKACDLVCADRCSLFMVNETRDQLYTS---- 470
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
F GL I +PIN GI G A+S +NI DAY D RFNR+ D+ TGY+T ++
Sbjct: 471 -FSGGL-----ANSIYIPINAGIVGSCAMSQSILNIRDAYEDPRFNRNTDKQTGYRTKTL 524
Query: 430 LCMP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQ 488
LC+P I G + GV +M+NK D +F DDE E+F+ F L++ +A+LY+ +
Sbjct: 525 LCVPIIDDHGNIQGVTEMINKMDG-HFSSDDEQMMEVFNVFCALSIENAKLYNASIELTM 583
Query: 489 KYRVALEV 496
+ + +E+
Sbjct: 584 QLKSIMEI 591
>UniRef50_P27815 Cluster: cAMP-specific 3',5'-cyclic
phosphodiesterase 4A; n=160; Eumetazoa|Rep:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Homo
sapiens (Human)
Length = 886
Score = 117 bits (282), Expect = 1e-24
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 393 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 452
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 453 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 510
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 511 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 570
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 571 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 630
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 631 CDKHTASVE-KSQVGFIDYIVHPLWE 655
>UniRef50_Q23RI8 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Tetrahymena thermophila SB210|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Tetrahymena thermophila SB210
Length = 807
Score = 117 bits (281), Expect = 2e-24
Identities = 77/259 (29%), Positives = 128/259 (49%), Gaps = 7/259 (2%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKS-DVKERFDYNKA 605
D+F + + L + + V Y+ YHN H + V M+ ++S + D +
Sbjct: 514 DVFFKAKIEPQHLFNWAVLVSNGYQDNFYHNKMHAFDVTQTMHYFMQSLNFIGIADLSGL 573
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHN 664
L +++A HD H G+ N Y+ T + LA Y S LE+HH T ++Q++ N
Sbjct: 574 EIGL-MYIAAAAHDYQHPGFNNPYLINTRNELAIRYNDKSPLENHHAFSTFLLMQEENCN 632
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
IF H++ +++K+ I IL TD + F +L K++ S + F D +D+ M
Sbjct: 633 IFVHLTKDEFKKSRERIISMILHTDNSQHFADLAKLKGRLTSQD--FDPKD-KDKDICMM 689
Query: 725 ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQV 784
+ +AD+S KPWEI + + +EF++QGD ER +G +PI + SQ
Sbjct: 690 SLLHSADVSNPYKPWEICRQWTFKVLDEFWNQGDLERQSG-LPITYLCDRFTTNTSKSQA 748
Query: 785 GFLSQICIPCYDMLYRILP 803
GF+ I P Y+ + + LP
Sbjct: 749 GFIDFIVKPLYESVQKFLP 767
>UniRef50_Q22000 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-4; n=7; Caenorhabditis elegans|Rep: Probable
3',5'-cyclic phosphodiesterase pde-4 - Caenorhabditis
elegans
Length = 674
Score = 116 bits (279), Expect = 3e-24
Identities = 82/284 (28%), Positives = 135/284 (47%), Gaps = 14/284 (4%)
Query: 524 DFYLDPFRFDEFEKCKCI----ISMFR--DLFDMTQFDITTLTRFTLTVKKNYRTVPYHN 577
D+ D F+ DE K + S+ R +LF + +TL + L ++ +YR YHN
Sbjct: 349 DWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYRNNHYHN 408
Query: 578 FDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPL 637
F H VA +M+ +L S V + A+F + HD+DH G+TN+Y+ + + L
Sbjct: 409 FIHAADVAQSMHVLLMSPVLTEV-FTDLEVLAAIFAGAV-HDVDHPGFTNQYLINSNNEL 466
Query: 638 AAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN 696
A MY S LE HH + +LQ + +++S + + + +LATD++
Sbjct: 467 AIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSL 526
Query: 697 LDKIRELYRSDEAQ----FSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEE 752
L ++ + + + D + + + + ADLS KP E+ + + I EE
Sbjct: 527 LADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEE 586
Query: 753 FYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYD 796
++ QGDKE+ G PM DR + SQVGF+ I P Y+
Sbjct: 587 YWRQGDKEKELGLEISPMCDRGNVTIE-KSQVGFIDYIVHPLYE 629
>UniRef50_A2FCG3 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 647
Score = 115 bits (277), Expect = 5e-24
Identities = 68/157 (43%), Positives = 99/157 (63%), Gaps = 14/157 (8%)
Query: 327 MVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRM 386
+++ DQL + I+ +++LV+ADR SLF D L+S K G + + I +
Sbjct: 501 VINKDQLFEMIMLRSRKLVSADRCSLFTTDRNREYLLS-----KVASGTN-----RSIVL 550
Query: 387 PINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI--KVEGKVIGVV 444
PI+ GIAGHVA +G+ +NIPDAY D RFN+DVD +TGY+T SILC+PI + E +VIGV
Sbjct: 551 PISHGIAGHVATTGQLLNIPDAYEDPRFNKDVDLSTGYRTKSILCVPIIGRAE-QVIGVT 609
Query: 445 QMVNKRDD-KYFGDDDEAAFEIFSTFFGLALHHARLY 480
QM+NK + F D + F+ F G+AL +A+ +
Sbjct: 610 QMINKTGEATQFTPGDVDLMKAFNVFCGIALSNAKSF 646
Score = 37.9 bits (84), Expect = 1.3
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 382 KEIRMPINRG-IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-- 438
K+ R+P+ +G IA VA G +NIP A F++ VD+ Y++ ++ P+ E
Sbjct: 370 KKQRLPLAQGGIAAFVAQDGNLVNIPVASQHPHFSKIVDDE--YRSRPVIAAPMINESSA 427
Query: 439 --KVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
++ GV KR F + D + E S L + + Y
Sbjct: 428 NHEIFGVAVARGKRGSMTFTEHDAISLESLSAVIARTLSNFQRY 471
>UniRef50_A5V6C5 Cluster: Putative adenylate/guanylate cyclase; n=1;
Sphingomonas wittichii RW1|Rep: Putative
adenylate/guanylate cyclase - Sphingomonas wittichii RW1
Length = 903
Score = 115 bits (276), Expect = 7e-24
Identities = 74/170 (43%), Positives = 98/170 (57%), Gaps = 11/170 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
+L+V + E+ L+ LI RI+ L+NA+R++LF+ D + EL S F G
Sbjct: 335 ILEVSNDLAGEL-KLEILIARIMRTTTELLNAERSTLFVYDRKTDELFSL-----FAEG- 387
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
DL +EIR+P NRGIAG V SG I D Y+D RFN +VD ATG+ T SILC PI
Sbjct: 388 DL---VREIRLPSNRGIAGAVFTSGVAETITDPYADPRFNPEVDRATGFVTRSILCQPIF 444
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
G IGV Q++NKRD F DEA FS + L +ARL+D ++
Sbjct: 445 DKHGGRIGVTQVLNKRDAAAFTAKDEARLRAFSAQIAVCLENARLFDDVL 494
>UniRef50_Q6S998 Cluster: CAMP-specific phosphodiesterase; n=3;
Leishmania|Rep: CAMP-specific phosphodiesterase -
Leishmania major
Length = 631
Score = 115 bits (276), Expect = 7e-24
Identities = 75/280 (26%), Positives = 130/280 (46%), Gaps = 7/280 (2%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYNKA 605
D + D + V+ +Y PYHN H V + I + + +R D +
Sbjct: 356 DFLQKFKIDEQIALNWISAVEASYHGNPYHNSMHAADVLQITDFIITQGGLAKRCDLSDI 415
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHN 664
AL A + HD DH G N + +T S LA +Y S LE+ H + +++ N
Sbjct: 416 QVFSALLAASI-HDFDHPGINNNFHIKTGSYLATLYNDRSVLENLHVSSVFELMKNPAFN 474
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA 724
I + S E + E+ + +LATD+ + + + L + S+ + ++L +A
Sbjct: 475 ILASFSDEQHHEVRETMIEMVLATDMGS---HGKYVASLKGKMQEHSSFTQTAEQNLCLA 531
Query: 725 ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQV 784
I++ AD+S +P +I ++ + +EFY QGD+ER G P MDR +P SQ+
Sbjct: 532 IALKMADISNCGRPLDIYLRWGAKVSDEFYQQGDRERNLGLECSPFMDRLQP-SLAKSQI 590
Query: 785 GFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
F++ I P ++ + +LP+ + A+ +N W D
Sbjct: 591 AFMNYIITPFFEQVAELLPDMRFAVALVEENKAYWANHDD 630
>UniRef50_Q005X2 Cluster: Phosphodiesterase 1; n=1;
Strongylocentrotus purpuratus|Rep: Phosphodiesterase 1 -
Strongylocentrotus purpuratus (Purple sea urchin)
Length = 680
Score = 115 bits (276), Expect = 7e-24
Identities = 73/235 (31%), Positives = 119/235 (50%), Gaps = 17/235 (7%)
Query: 574 PYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSET 633
PYHN H V ++ +L + A +A + HD +H G TN + T
Sbjct: 284 PYHNLLHAADVTQTVHHMLAR--MGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNT 341
Query: 634 ASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAA 692
S +A Y + LE+HH + + +++ D NI +++S E+Y E+ + +LATD++
Sbjct: 342 KSDMAMFYNDRAVLENHHISSSFRLMRDDERNILANLSKEEYTELRNLVIDMVLATDMSF 401
Query: 693 FFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEE 752
F + +++ + + EA D P MA+++ AD+S +K W+ K ++ E
Sbjct: 402 HFQQIKQMKSMISTTEA---LDKPK----VMALTLHCADISHPSKEWKFHYKWTTLLIRE 454
Query: 753 FYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP----CYDMLYRIL 802
F+ QGD+ER G +PI P+ DRN SQ+GF+ I P C DM+ RIL
Sbjct: 455 FFRQGDREREMG-LPISPLCDRNS-TLLAESQIGFIDFIVDPSMNICGDMIDRIL 507
>UniRef50_Q13946 Cluster: High affinity cAMP-specific 3',5'-cyclic
phosphodiesterase 7A; n=73; Euteleostomi|Rep: High
affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
- Homo sapiens (Human)
Length = 482
Score = 114 bits (275), Expect = 9e-24
Identities = 91/326 (27%), Positives = 155/326 (47%), Gaps = 24/326 (7%)
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ R +R + +R S + +Y QA + ++ N +F D F FD
Sbjct: 114 FQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNF-----DIFLFDRLTNGN 168
Query: 540 CIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL 592
++S+ LF + D+ L RF + ++++Y + PYHN H V AM+ L
Sbjct: 169 SLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYL 228
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHF 651
K + K L+L +A HDLDH G ++ +T LA +Y TS LE+HH+
Sbjct: 229 K-EPKLANSVTPWDILLSL-IAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 286
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS--DEA 709
V +L++ G +FSH+ E +++ I ILATD++ ++ L+RS D
Sbjct: 287 RSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS----RQNEYLSLFRSHLDRG 340
Query: 710 QFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP 769
+D HR L + +++ AD+ + WE+ + + + EEF+ QGD E+ P
Sbjct: 341 DLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400
Query: 770 MMDRNKPEEQPASQVGFLSQICIPCY 795
+ DR+ E Q+GF++ + P +
Sbjct: 401 LCDRH-TESIANIQIGFMTYLVEPLF 425
>UniRef50_Q7A2D9 Cluster: Adenylate cyclase; n=6; Cyanobacteria|Rep:
Adenylate cyclase - Anabaena sp. (strain PCC 7120)
Length = 859
Score = 113 bits (273), Expect = 2e-23
Identities = 78/252 (30%), Positives = 133/252 (52%), Gaps = 13/252 (5%)
Query: 251 NYILYQPIITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCK-LYVDKK 307
N IL P+++ + V+++ F DEE + L C+ YV +
Sbjct: 157 NNILCMPVVSSKDQIVAVVQLANKTGNIPFNRNDEESFRDFAASIGIILETCQSFYVAAR 216
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVF 367
+R ++ LL + + + + L+ ++ ++E A+ L+ ADR++LFL EL +
Sbjct: 217 NQRGVTA-LLRATQTLGQSL-DLEATLQIVMEQARILMQADRSTLFLYRKEMGELWT--- 271
Query: 368 DLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTI 427
K D + EIR+P NRGI G+VA +G+ +NI DAY D RF+ D TGY T
Sbjct: 272 --KVAAAADTT-QLIEIRIPANRGIVGYVASTGDALNISDAYKDPRFDPTTDRKTGYLTR 328
Query: 428 SILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
+ILC+P+ ++IGV Q++NK+ + D+E F+ G+AL +ARL++ ++ +
Sbjct: 329 NILCLPVFNSANELIGVTQLINKQQGSFTASDEE-FMRAFNIQAGVALENARLFENVLLE 387
Query: 487 EQKYRVALEVLS 498
+Q + L+ LS
Sbjct: 388 KQYQKDILQSLS 399
Score = 80.2 bits (189), Expect = 2e-13
Identities = 48/151 (31%), Positives = 84/151 (55%), Gaps = 12/151 (7%)
Query: 329 SLDQLIKRILEFAQ----RLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEI 384
+L+ +++++LE +++ A+ ++FLVDY +L S V D + EI
Sbjct: 62 ALENMLEKVLEAITLKIGQILQAEHTAIFLVDYDKCQLWSKVPQ-------DNGQKFLEI 114
Query: 385 RMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP-IKVEGKVIGV 443
R PI GI GHVA +G+ +NI + + F+ +++ GYK +ILCMP + + +++ V
Sbjct: 115 RTPITVGIPGHVASTGQYLNISETATHPLFSPELERQMGYKINNILCMPVVSSKDQIVAV 174
Query: 444 VQMVNKRDDKYFGDDDEAAFEIFSTFFGLAL 474
VQ+ NK + F +DE +F F+ G+ L
Sbjct: 175 VQLANKTGNIPFNRNDEESFRDFAASIGIIL 205
>UniRef50_UPI00006CB6E9 Cluster: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein; n=1; Tetrahymena
thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein - Tetrahymena
thermophila SB210
Length = 699
Score = 113 bits (272), Expect = 2e-23
Identities = 96/330 (29%), Positives = 155/330 (46%), Gaps = 25/330 (7%)
Query: 512 LLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMF--RDLFDMTQFDITTLTRFTLTVKKN 569
L KE + F D F+ D+ EK + I S+F R+ F+ + I+ F ++
Sbjct: 239 LTKKEQEDTLLDQFKFDIFKADQKEKVRIIWSIFQKRNYFEKYKIPISQFCEFIQEIRLR 298
Query: 570 Y--RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTN 627
Y R P+HNFDHG TV H Y + V + K + AL + LCHD+ H TN
Sbjct: 299 YNKRGNPFHNFDHGITVMHGCYMLCCQTVAQTII--KEINEFALIFSGLCHDVSHTARTN 356
Query: 628 KYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
+ + S LA Y S LE HH +T IL++ NI + + E ++I + IL
Sbjct: 357 LFEVNSMSKLAIRYHDKSVLEQHHIAVTFKILRKKEANILTQLPLEQVQQIRKIVISNIL 416
Query: 687 ATDLAAFFPNLD-----------KIRELYRSDEAQF-SWDDPSHRDLAMAISMT--AADL 732
ATD+ F L K++ ++ +E + S S DL + +M AAD
Sbjct: 417 ATDIKQHFDLLKDFELRFGNKGLKLKNDFQINEQECQSVTTYSDNDLNLITNMMIHAADF 476
Query: 733 SASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIP-IP-MMDRNKPEEQPASQVGFLSQI 790
+A+ +E+ K ++ +EF Q KE A IP P + D +K + S++GF++ I
Sbjct: 477 HGNAQEFELSKKWSLLVNQEFQAQ-YKEEAEKNIPQTPYLKDLDKRDILAKSEIGFINAI 535
Query: 791 CIPCYDMLYRILPNTKPMYA-MATKNLNRW 819
P +++L + L + + + N+ +W
Sbjct: 536 VKPLWELLNKFLGDDLQISTNNLSNNIKQW 565
>UniRef50_A3WDP1 Cluster: Adenylate/Guanylate Cyclase; n=1;
Erythrobacter sp. NAP1|Rep: Adenylate/Guanylate Cyclase
- Erythrobacter sp. NAP1
Length = 767
Score = 113 bits (272), Expect = 2e-23
Identities = 79/248 (31%), Positives = 131/248 (52%), Gaps = 13/248 (5%)
Query: 253 ILYQPIITKSGKTSYVLEMW-RTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERN 311
IL PI G+T V ++ + F D ++ I ++ L +L + R
Sbjct: 134 ILASPIRNARGETIGVAQVLNKVAGEFNEQDLQVLEGITSQCAITLESMQLVERMEDSRR 193
Query: 312 MSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKF 371
L++V + E+ L L++R++ A +++A+R++LF+ D + +EL S V +
Sbjct: 194 REIEFLNIVSEMTSEL-ELTTLLRRVMTEATSMLDAERSTLFINDEKTAELFSHVGE--- 249
Query: 372 EPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILC 431
GLD EIR+P + GIAG V SGE +NIP AY+D RFN D+ +G+ T SILC
Sbjct: 250 --GLDA----MEIRLPNHLGIAGSVFTSGEAINIPHAYTDLRFNPAFDKQSGFFTRSILC 303
Query: 432 MP-IKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKY 490
+P + G+ IGV Q++NKR F ++DE+ + F+ + L +A+L+ I +
Sbjct: 304 VPVVNKSGETIGVTQVLNKRGGP-FNEEDESRLKAFTAQIAIGLENAKLFADIQSMKNYN 362
Query: 491 RVALEVLS 498
L+ +S
Sbjct: 363 ESMLQSMS 370
Score = 86.6 bits (205), Expect = 3e-15
Identities = 60/184 (32%), Positives = 96/184 (52%), Gaps = 12/184 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
+LDV + + + +LD ++ ++ A A+R SLFL D + EL S +
Sbjct: 31 ILDVSRQV-ASLETLDAVLDTLVTVAVETTGAERGSLFLHDASSGELYSRIAQ------- 82
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
M+++EIR+ GIAG SGE + I D Y+D RFN+DVD TG+ T SIL PI+
Sbjct: 83 --GMKRREIRILDTIGIAGTTFQSGEGLIIHDPYTDPRFNKDVDAQTGFTTTSILASPIR 140
Query: 436 -VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
G+ IGV Q++NK + F + D E ++ + L +L +R+ ++ L
Sbjct: 141 NARGETIGVAQVLNKVAGE-FNEQDLQVLEGITSQCAITLESMQLVERMEDSRRREIEFL 199
Query: 495 EVLS 498
++S
Sbjct: 200 NIVS 203
>UniRef50_Q4N806 Cluster: 3',5' cyclic nucleotide phosphodiesterase,
putative; n=2; Theileria|Rep: 3',5' cyclic nucleotide
phosphodiesterase, putative - Theileria parva
Length = 450
Score = 113 bits (272), Expect = 2e-23
Identities = 70/233 (30%), Positives = 117/233 (50%), Gaps = 6/233 (2%)
Query: 557 TTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACL 616
T L ++++Y PYHN H TV H M +L + V + N A ++ L
Sbjct: 151 TNLIPVLQNLQQHYLANPYHNALHAATVGH-MSKLLSNIVTTKRRLNPYEE-FAFIISSL 208
Query: 617 CHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYK 675
HD+ H G TN Y+S T++ L+ +Y STLE++H ++ I++ + N +S I + +
Sbjct: 209 AHDVGHPGKTNNYLSNTSNVLSLIYNDNSTLENYHCSLLFYIIKNNT-NFYSIIPKDIWP 267
Query: 676 EILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSAS 735
+ I IL+TD+ F ++D ++E + DD L + + + AAD+ +
Sbjct: 268 SLRKRIIQLILSTDMINHFLHIDNVKEKRLQGKFDIKNDDDFW--LLLVLCIKAADIGHN 325
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLS 788
PW + +V+FEEFY QGD+E+ P+ DRN+ P Q+ F +
Sbjct: 326 FLPWADHLPWTQVLFEEFYKQGDEEKMQSISPLMFFDRNESRNIPILQLQFFN 378
>UniRef50_O96075 Cluster: EFPDE1; n=1; Ephydatia fluviatilis|Rep:
EFPDE1 - Ephydatia fluviatilis
Length = 628
Score = 113 bits (272), Expect = 2e-23
Identities = 66/225 (29%), Positives = 113/225 (50%), Gaps = 6/225 (2%)
Query: 574 PYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSET 633
PYHN H V ++ ++ S E + + LA+ +A HDL+H G TN + ++
Sbjct: 277 PYHNSTHAADVLQTVHYLISSTGLEH--WISSLEVLAILLAATVHDLEHTGTTNTFHIQS 334
Query: 634 ASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAA 692
+ A +Y + LE+ H N T+L++D NI ++ ED++ + + +LATD+++
Sbjct: 335 YTDYALLYNDRAVLENFHLNRAFTLLKEDELNILKNLKLEDFRLVRSLVVEMVLATDMSS 394
Query: 693 FFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEE 752
L +R+L S + + + L + + M AD+S K WE + + EE
Sbjct: 395 HSDQLKHMRQLISSPDVIVQIEKGRSKVLCLLLHM--ADISHPGKEWETHQEFSSRLVEE 452
Query: 753 FYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
F+ QGD+E GR P+ +RN P Q+GF+ I P +D+
Sbjct: 453 FFRQGDQEMQLGRTCSPLCNRN-TTSVPECQLGFIDYIVSPSFDV 496
>UniRef50_A2F9J4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1119
Score = 113 bits (272), Expect = 2e-23
Identities = 80/315 (25%), Positives = 138/315 (43%), Gaps = 14/315 (4%)
Query: 521 DFADFYLDPFRFDEFEKCKCIISMF--RDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNF 578
+++D + +++ ++ I+ +F + + Q LT+F +++ Y PYHN+
Sbjct: 809 EYSDRLFNILSYNDDDRMIMILKLFVSQGVIRKLQVPFQKLTQFICSLRSCYNVTPYHNW 868
Query: 579 DHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPL 637
H V +++ I++ +++ Y AL +A +CHD+DH G N + + +PL
Sbjct: 869 THACDVMQFVFSCIIRGHLRQ---YLNDLEIFALLLAAICHDVDHHGLNNAFHKKARTPL 925
Query: 638 AAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISS-EDYKEILGFIRHCILATDLAAFFP 695
+Y +E HH + +L H+I I S D F ILATD+
Sbjct: 926 GILYEDKPVMEMHHCATAIRLLAMPEHDILEGIESYADKCHFYEFFIKIILATDMEKHMQ 985
Query: 696 NLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYD 755
+ E+ + +F + HR L I + A DLS + + ++ + EEF+
Sbjct: 986 YIKDFEEVTK----EFDKRNEKHRLLLAQIVIKAGDLSNTTRAFDTAAAMATNLMEEFFK 1041
Query: 756 QGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKN 815
QGD E G PM DR+K SQVGF P L + + + KN
Sbjct: 1042 QGDLESKLGVEITPMCDRSKATHISCSQVGFYGFCASPLLTALGKFITSLADNTEQLEKN 1101
Query: 816 LNRWKARADKILFKQ 830
W+ + KI ++Q
Sbjct: 1102 KRVWEQQ--KIQWEQ 1114
Score = 38.3 bits (85), Expect = 0.95
Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 20/203 (9%)
Query: 332 QLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRG 391
Q + I FA L NA LF + + +++VS + D ++ +++P+ RG
Sbjct: 126 QFLHSIENFACTLFNAGSCRLFTLQPQQNQMVSYI-----------DNDRFTLQVPLGRG 174
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI--KVEGKVIGVVQMVNK 449
I G A +G+ + + ++ ++D+ + + +PI VI V+ +
Sbjct: 175 IVGCCAKAGKVVVLQSTKDSSSYDPEIDDYFNIGDNAAMLIPIFDSSSNFVISVLLVHTP 234
Query: 450 RDDKYFGDDDEAAFEIFSTFFGLAL-----HHARLYDRIMRKEQKYRVALEVLSYHNTCR 504
+ +F +D I ST L H + DR++R+E + V +L NT
Sbjct: 235 KVGAFFSPEDLEIGLILSTQISPFLTSYVEHMEKNDDRVVRQEIAHGV--NILLGKNTLE 292
Query: 505 EYEVQAMLLDKEPLNVDFADFYL 527
E + + + ++ + A+ Y+
Sbjct: 293 ELLPTILSVVQHAVSTNDAELYM 315
>UniRef50_A7AS42 Cluster: 3'5'-cyclic nucleotide phosphodiesterase,
putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide
phosphodiesterase, putative - Babesia bovis
Length = 485
Score = 113 bits (271), Expect = 3e-23
Identities = 76/268 (28%), Positives = 127/268 (47%), Gaps = 9/268 (3%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
+++ Y PYHN HG VAH +LK+ E+ Y + A +A L HD H G
Sbjct: 200 SIQDVYLPNPYHNALHGACVAHMSCVLLKALSLEQ--YLTPLEQFAYLIAALGHDAGHPG 257
Query: 625 YTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
TN ++ T +PLA +Y S LE++H ++ I++ + F + +D++ I I
Sbjct: 258 KTNAFLRSTQNPLALIYNDASILENYHASLVCHIIRAK-EDFFGLFNQQDWEIIRKRIIQ 316
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
+LATD+ F +++ ++E S + ++P + + + AD+ + PW +
Sbjct: 317 LVLATDMMTHFTHVNNVKERRLSGTFDYV-NNPEDLWFCLVLLVKTADIGHNFLPWCEHL 375
Query: 744 KTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
+F+EF+ QGD+ER + DR + + P SQ+GF P D L I
Sbjct: 376 PWTNALFDEFHMQGDEERLLSLPLLLFFDRTRSADIPDSQLGFFQGFTSPLIDELTFINT 435
Query: 804 NTKP----MYAMATKNLNRWKARADKIL 827
N+ + A A NL WK + + L
Sbjct: 436 NSTYLNDFLNANAHDNLEHWKKNSKRQL 463
>UniRef50_A4VDP2 Cluster: Cyclic nucleotide phosphodiesterase; n=1;
Tetrahymena thermophila SB210|Rep: Cyclic nucleotide
phosphodiesterase - Tetrahymena thermophila SB210
Length = 1074
Score = 112 bits (270), Expect = 4e-23
Identities = 81/299 (27%), Positives = 147/299 (49%), Gaps = 18/299 (6%)
Query: 516 EPLNVDFADFYLDPFRFDEFEKCKC--IISMFRDLFDMTQFDITTLTRFTLTVKKNY--R 571
E +N++ +F +D +++DE +K K +I R+ F + I F +++ Y R
Sbjct: 721 EQINLELENFGIDIWKYDENQKLKIAWLIMEKRNYFKEYEIPIEEFITFLYKLREKYNKR 780
Query: 572 TVPYHNFDHGWTVAHAMYAI-LKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYM 630
P+HNFDHG V H + I +++ + Y + +L + LCHD+ HRG TN +
Sbjct: 781 ENPFHNFDHGIMVMHGCFMIGCRTNANK---YLNSIQEFSLVFSGLCHDVSHRGKTNAFE 837
Query: 631 SETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATD 689
T S LA Y S LE HH T IL+Q NIF +++ + ++I ++ + ILATD
Sbjct: 838 VNTMSKLAIRYHDQSVLEQHHIAHTFKILRQSNANIFKNLTIQKVQQIRRYVINNILATD 897
Query: 690 LAAFFPNL-----DKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIK 744
++ F L D ++E+++ + QF + +L + +D +A+ +E+ +
Sbjct: 898 MSKHFDYLKDFQNDFLQEVHKKESNQF---EEKEINLLTGTIIHTSDFHHTAQKFELSKQ 954
Query: 745 TVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL 802
+ +EF Q +E G + + D +K ++ GF+ I P ++ + + L
Sbjct: 955 WSVKVNKEFSQQYIEEGKQGVQQTSYLKDLDKMHVLAKNEAGFIKMIVKPLWETMNKFL 1013
>UniRef50_Q9W4T4 Cluster: cAMP-specific 3',5'-cyclic
phosphodiesterase, isoform I; n=38; Coelomata|Rep:
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I -
Drosophila melanogaster (Fruit fly)
Length = 1209
Score = 112 bits (269), Expect = 5e-23
Identities = 84/302 (27%), Positives = 142/302 (47%), Gaps = 12/302 (3%)
Query: 502 TCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCI-ISMFRDLFDMTQFDITTLT 560
T RE E+ +L + + + F + F + C I R+L T
Sbjct: 797 TPRENELGTLLGELDTWGIQI--FSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFL 854
Query: 561 RFTLTVKKNY-RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHD 619
F T++ +Y + P+HN H V + +L + E + ALF AC+ HD
Sbjct: 855 NFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGV-FTPLEVGGALFAACI-HD 912
Query: 620 LDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
+DH G TN+++ ++S LA MY S LE+HH + +LQ G +IF ++ + + +
Sbjct: 913 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLR 972
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHRDLAMAISMTAADLSA 734
+ +L+TD++ L ++ + + + S D+ + R + + ADLS
Sbjct: 973 KMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSN 1032
Query: 735 SAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPC 794
KP + + V ++ EEF+ QGDKER +G PM DR+ + SQVGF+ I P
Sbjct: 1033 PTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIE-KSQVGFIDYIVHPL 1091
Query: 795 YD 796
++
Sbjct: 1092 WE 1093
>UniRef50_UPI0000DB6B8B Cluster: PREDICTED: similar to
phosphodiesterase 7A isoform a; n=1; Apis mellifera|Rep:
PREDICTED: similar to phosphodiesterase 7A isoform a -
Apis mellifera
Length = 1148
Score = 111 bits (268), Expect = 6e-23
Identities = 81/278 (29%), Positives = 125/278 (44%), Gaps = 11/278 (3%)
Query: 548 LFDMTQFDITTLTRFTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
L D+ T+ + +++ Y T PYHN H V AM+ L+ + K R
Sbjct: 68 LLQYFNLDVVTVWKLFAFIEEGYHSTNPYHNSIHATDVTQAMHCFLQEE-KIRTHLTNLE 126
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNI 665
+A +A + HDLDH G ++ T++ LAA+Y TS LE+HH+ + L + G +
Sbjct: 127 I-MASLIAAVTHDLDHPGVNQPFLVATSNHLAALYQNTSVLENHHWRSAIGCLLESG--V 183
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
+ + E+ I ILATD+ L IR + DE R + I
Sbjct: 184 SDQLPAHVRPELQRHISSLILATDITRQQEFL--IRFKHYLDENLLEMKRADDRHFILQI 241
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVG 785
++ AD+S +PW+I K + EEF+ QGD ER P+ DR+ P Q G
Sbjct: 242 ALKCADISNPCRPWDISQKWSHKVCEEFFRQGDYERRLNLPVTPLCDRHTTSI-PKIQAG 300
Query: 786 FLSQICIPCYDMLYRILPNTKPMYAM--ATKNLNRWKA 821
F + P Y+ +R L + + M N +W+A
Sbjct: 301 FFKFVVTPLYEEWHRFLGDGLSVSLMEHLRANQKKWEA 338
>UniRef50_UPI0000DB7125 Cluster: PREDICTED: similar to
Phosphodiesterase 1c CG14940-PA; n=1; Apis
mellifera|Rep: PREDICTED: similar to Phosphodiesterase
1c CG14940-PA - Apis mellifera
Length = 731
Score = 111 bits (267), Expect = 8e-23
Identities = 78/254 (30%), Positives = 124/254 (48%), Gaps = 18/254 (7%)
Query: 557 TTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVA 614
T L F V++ Y PYHN H VA M+ IL ++ A VA
Sbjct: 420 TVLECFLGRVEEGYCRHRNPYHNNLHAADVAQTMHYILCQT--GLMNWLTDLEIFATLVA 477
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSED 673
+ HD +H G TN + + S A +Y + LE+HH + + I+++D NI ++S E+
Sbjct: 478 AIIHDYEHTGTTNNFHVMSGSDTALLYNDRAVLENHHISASFRIMREDECNILQNLSREE 537
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPS-HRDLAMAISMTAADL 732
++E + +LATD++ F L ++ + S +PS + A+++ + D+
Sbjct: 538 FREFRSLVIDMVLATDMSFHFQQLKNMKNI-------LSLAEPSVDKSKAVSLVLHCCDI 590
Query: 733 SASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICI 792
S AK W++ + + EEF+ QGDKE+A G P+ DRN SQ+GF+ I
Sbjct: 591 SHPAKRWDLHHRWTMQLLEEFFRQGDKEKALGLPFSPLCDRNN-TLVAESQIGFIEFIVE 649
Query: 793 P----CYDMLYRIL 802
P C DML +L
Sbjct: 650 PSMQVCSDMLETVL 663
>UniRef50_UPI00006CBCA5 Cluster: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein; n=1; Tetrahymena
thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein - Tetrahymena
thermophila SB210
Length = 649
Score = 111 bits (267), Expect = 8e-23
Identities = 68/262 (25%), Positives = 113/262 (43%), Gaps = 5/262 (1%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCH 618
L F ++K Y YHN H + V LKS ++++ CH
Sbjct: 366 LFNFFKQIEKGYNDNLYHNRLHAFDVLQTANFFLKSCNFIEIAAINEFDLCTIYISAACH 425
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEI 677
D DH G N ++ T+ +A Y S LE+HH + T + +I ++ + E Y+
Sbjct: 426 DYDHPGVNNAFIINTSHEIALTYNDQSVLENHHASKTFQLFNDQNLDITANFTKEQYRSF 485
Query: 678 LGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAK 737
+ IL+TD+A F ++ K++ +D+ D + + + + A D+S K
Sbjct: 486 REMVISIILSTDMAKHFSDIAKLKSRLGTDDYDIKGKD---KQMCIDTIIHACDVSNPVK 542
Query: 738 PWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W + + + EF+ QGD+ER+ G I I + SQVGF+ I P Y++
Sbjct: 543 TWNVYQQWAHRVLSEFWSQGDQERSQG-IQITYLCDRYTTNTAKSQVGFIDFIVKPLYEV 601
Query: 798 LYRILPNTKPMYAMATKNLNRW 819
+ LP K N +W
Sbjct: 602 ICNFLPELKNYMQQIDSNKQKW 623
>UniRef50_A7SGA1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 358
Score = 111 bits (267), Expect = 8e-23
Identities = 77/260 (29%), Positives = 118/260 (45%), Gaps = 13/260 (5%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYR--TVPYHNFDHGWTVAHAMYAILKSDVKERFDYN 603
RD+ + TL RF V+ Y+ + PYHN H V H ++ L+ + Y
Sbjct: 108 RDMLRNFKIHAMTLDRFLQDVETGYKRHSNPYHNDCHAADVTHTVHYFLECMGVSK--YL 165
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
L ++ + HDL+H G TN + + S LA +Y S LE+HH + ILQ D
Sbjct: 166 SDLEVFGLLLSAIIHDLEHTGTTNAFHINSRSDLALLYNDRSVLENHHVSCAFRILQDDE 225
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI S ++ E Y ++ + +LATD+++ F L R + P
Sbjct: 226 KNILSGLNLEQYADVRSLMIDTVLATDMSSHFEQL-------RLMKVALVAGSPIENREV 278
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
+ + + AD+S K W I + I EEF+ QGD E G P+ DR+ P S
Sbjct: 279 VQLLLHVADISNPTKDWTIHRQWTTKIMEEFFTQGDMEIELGLDVSPLCDRS-TTLIPES 337
Query: 783 QVGFLSQICIPCYDMLYRIL 802
Q+GF+ I P ++ +L
Sbjct: 338 QIGFIDFIVSPALEVCSEVL 357
>UniRef50_Q4N6H0 Cluster: Putative uncharacterized protein; n=1;
Theileria parva|Rep: Putative uncharacterized protein -
Theileria parva
Length = 840
Score = 110 bits (265), Expect = 1e-22
Identities = 76/253 (30%), Positives = 120/253 (47%), Gaps = 11/253 (4%)
Query: 552 TQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL 609
T F+I T + F V+K Y V YHN HG V + + S+ + R
Sbjct: 581 THFNIPTDVIYSFLGLVEKCYNNVSYHNQMHGVFVCQKLLCL--SNFTNVYSRLSVIDRT 638
Query: 610 ALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSH 668
L ++ LCHD+ H G TN + + LA ++ S LE+ H +T +L+Q N+FS
Sbjct: 639 ILIISGLCHDIGHPGLTNAFFINSGHQLAHLFNDKSVLENFHCCLTFNVLRQS--NLFSF 696
Query: 669 ISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMT 728
+ E+ K + I IL+TDL F + + R R +FS + D + +
Sbjct: 697 LDKEEMKIVRRKIIQLILSTDLEDHFQTITQFR--VRRASREFSVE--GEIDTICKMLIK 752
Query: 729 AADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLS 788
A+D+ +S W + ++ + + +EFY QG +E + G P+ D NK P +Q GFL+
Sbjct: 753 ASDIGSSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPLCDPNKHNHLPKAQSGFLA 812
Query: 789 QICIPCYDMLYRI 801
IP Y + I
Sbjct: 813 IFVIPLYTEIANI 825
>UniRef50_UPI000150A113 Cluster: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein; n=1; Tetrahymena
thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein - Tetrahymena
thermophila SB210
Length = 569
Score = 110 bits (264), Expect = 2e-22
Identities = 74/265 (27%), Positives = 125/265 (47%), Gaps = 8/265 (3%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKS-DVKERFDYNKASSRLALFVACLC 617
L F+ +++ Y PYHN H + V M+ LK + + NK +FVA
Sbjct: 249 LYHFSDIIQQKYLGNPYHNKIHAFDVTQTMHFFLKKCNFVQIGKLNKIDIG-TVFVAAAI 307
Query: 618 HDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQD-GHNIFSHISSEDYK 675
HD++H G+ N + + LA +Y S LE+HH ++T +L+ + NIF I + YK
Sbjct: 308 HDVEHPGFNNPFQMNAKTDLAILYNDKSPLENHHLSVTFKLLRDNPSINIFEGIDKKTYK 367
Query: 676 EILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSAS 735
+ + IL TD+ F +L +++ S+E D + L + + AAD+S
Sbjct: 368 NVRETLIQMILKTDMNQHFTSLAQLKGRLASNEFDAKAAD---KPLCLNTLLHAADVSNP 424
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
KP+ I + + EF+ QGD ER+ G +PI + SQ+GF+ I P +
Sbjct: 425 FKPFHIYQEWTHRVLNEFWIQGDVERSRG-LPISYLCDRYTTNIAKSQIGFIDFIVQPYF 483
Query: 796 DMLYRILPNTKPMYAMATKNLNRWK 820
+ + + +P + +N W+
Sbjct: 484 ETICQFIPELLNYMPLFEQNKQEWQ 508
>UniRef50_Q13945 Cluster: 3',5'-cyclic AMP phosphodiesterase; n=37;
Coelomata|Rep: 3',5'-cyclic AMP phosphodiesterase - Homo
sapiens (Human)
Length = 606
Score = 110 bits (264), Expect = 2e-22
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 245 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 303
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 304 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 362
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 363 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 422
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 423 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 482
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 483 -KSQVGFIDYIVHPLWE 498
>UniRef50_Q1IM31 Cluster: Serine phosphatase; n=1; Acidobacteria
bacterium Ellin345|Rep: Serine phosphatase -
Acidobacteria bacterium (strain Ellin345)
Length = 612
Score = 109 bits (261), Expect = 4e-22
Identities = 63/199 (31%), Positives = 109/199 (54%), Gaps = 11/199 (5%)
Query: 294 SVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLF 353
++ALH D ++ L + + + + L +L++ I++ A+ V ADR S+F
Sbjct: 160 AIALHQMFASEDSQKTITQLSLLFEATR-LLNSTLDLAELLELIMKIARTEVKADRGSVF 218
Query: 354 LVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYR 413
LVD + EL S V +E +E+R+P RG+AG VA +GE +N+ DAY+
Sbjct: 219 LVDKAHKELWSIVAS---------GLEHQELRVPFGRGVAGRVAETGEVINVADAYTLPF 269
Query: 414 FNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGL 472
F+R D+ TGY T S+LC+PI+ +++GV+Q++N+ F +D+ + +
Sbjct: 270 FDRSFDQKTGYTTKSLLCLPIRHHNNEIVGVLQLLNQSTHGRFTPEDQEFLTKLTGHMAM 329
Query: 473 ALHHARLYDRIMRKEQKYR 491
AL +ARL+ + K++ R
Sbjct: 330 ALENARLHREALEKQRMER 348
>UniRef50_A0LL31 Cluster: Serine phosphatase; n=1; Syntrophobacter
fumaroxidans MPOB|Rep: Serine phosphatase -
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Length = 438
Score = 108 bits (260), Expect = 6e-22
Identities = 61/186 (32%), Positives = 103/186 (55%), Gaps = 7/186 (3%)
Query: 305 DKKRERNMSDFLLDVVK--AIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSEL 362
+ +R R D L + + A+ + LD++++ I+ ++ ++ AD SL LVD EL
Sbjct: 15 EMERYRERIDNLRECFRTSALINSTLELDEVLENIMTTSRSILKADACSLMLVDEATDEL 74
Query: 363 VSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEAT 422
V V G K R+ GIAGHV +G+ + I D Y D RF+++ D T
Sbjct: 75 VFAVAQ-----GPVAGKLKAGFRLRKGDGIAGHVFQTGKPLLIEDVYRDARFHQEFDRKT 129
Query: 423 GYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR 482
GY+T S+LC+P+K++ +VIGV Q++N+ D F +DE + +A+ +AR++
Sbjct: 130 GYRTHSMLCVPLKIKDRVIGVSQVINRLDGTSFVAEDEETLGLLCDHAAIAIENARMHRD 189
Query: 483 IMRKEQ 488
++RK+Q
Sbjct: 190 LLRKQQ 195
>UniRef50_O18696 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-1; n=2; Caenorhabditis|Rep: Probable 3',5'-cyclic
phosphodiesterase pde-1 - Caenorhabditis elegans
Length = 664
Score = 108 bits (259), Expect = 8e-22
Identities = 66/247 (26%), Positives = 119/247 (48%), Gaps = 13/247 (5%)
Query: 550 DMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
D + +T L + ++ Y PYHN H V + + +L +
Sbjct: 305 DRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDL--E 362
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIF 666
LA+ L HD +H G+TN + ++ S A +Y S LE+HH + ++++D NI
Sbjct: 363 LLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNIL 422
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
+H++ ++YKE+ + +LATD++ F + ++ + S + ++ A+ +
Sbjct: 423 THLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSM-------LSLPEGIDKNKALCLI 475
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
+ A D+S AKPW + + + + EEF+ QGD E + G P+ DR+ SQ+GF
Sbjct: 476 VHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVAD-SQIGF 534
Query: 787 LSQICIP 793
+ I P
Sbjct: 535 IDFIVEP 541
>UniRef50_Q4D500 Cluster: Phosphodiesterase, putative; n=3;
Trypanosoma cruzi|Rep: Phosphodiesterase, putative -
Trypanosoma cruzi
Length = 708
Score = 107 bits (258), Expect = 1e-21
Identities = 72/243 (29%), Positives = 118/243 (48%), Gaps = 7/243 (2%)
Query: 566 VKKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
V+ Y PYHN H V H + IL K + ER + ALF A + HD +H G
Sbjct: 452 VEAGYNGNPYHNSMHAADVLHITHYILSKGGMIERCQLSDLQVFAALFAAAI-HDYNHPG 510
Query: 625 YTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
N + +T + A +Y S LE+ H + +++ NI S + KEI +
Sbjct: 511 VNNNFHIKTQTYSAIVYNDRSVLENAHVSSVFELMKNPRFNILESFSEDQQKEIRETVIE 570
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
+LATD++ ++ + E S+ + +++LA+ +++ AD+S +P EI +
Sbjct: 571 MVLATDMSLHGKHIAHFNDRL---EEHASFTERENQNLALVMALKMADISNCGRPLEIYL 627
Query: 744 KTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
K + +EFY QGD+ER G P MDR +P Q+ F++ I IP ++ + LP
Sbjct: 628 KWSSKLSDEFYLQGDRERNLGVQCSPFMDRMEP-ALAKGQILFINYIIIPFFEKMAVFLP 686
Query: 804 NTK 806
+
Sbjct: 687 KMR 689
>UniRef50_UPI0000E46CDB Cluster: PREDICTED: similar to
phosphodiesterase 9A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to phosphodiesterase
9A - Strongylocentrotus purpuratus
Length = 526
Score = 106 bits (255), Expect = 2e-21
Identities = 62/197 (31%), Positives = 100/197 (50%), Gaps = 10/197 (5%)
Query: 612 FVACLC----HDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIF 666
F C C LD GY N Y + LA Y S LE+HH ++ IL++ NIF
Sbjct: 226 FKHCFCVSQMFSLDRPGYNNAYHVNAGTELALRYNDISPLENHHCSVAFKILEKPHCNIF 285
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
++S E +K++ I CILATD+A L+ +++ + F + + H+DL I
Sbjct: 286 KNLSPEIFKQVREGIIRCILATDMAKHNEILNGFKDIIST----FDFSNKVHKDLLTKIC 341
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
+ AD+S A+P ++ + + +EF++Q D E+ G P MDR K + SQ GF
Sbjct: 342 IKVADISNEARPMDVAEPWIDCLLQEFFNQSDMEKLEGLPVAPFMDREKVTKH-TSQTGF 400
Query: 787 LSQICIPCYDMLYRILP 803
+ + +P ++ L + P
Sbjct: 401 IRFVLLPLFESLGLLFP 417
>UniRef50_Q8SXR0 Cluster: RE69157p; n=9; Coelomata|Rep: RE69157p -
Drosophila melanogaster (Fruit fly)
Length = 834
Score = 106 bits (254), Expect = 3e-21
Identities = 72/244 (29%), Positives = 116/244 (47%), Gaps = 15/244 (6%)
Query: 570 YRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKY 629
YR PYHN H V ++ L + ++ A +A L HD +H G TN +
Sbjct: 464 YRN-PYHNNLHAVDVMQTIHYCLCNT--GLMNWLTDLEIFASLLAALLHDYEHTGTTNNF 520
Query: 630 MSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILAT 688
+ S A +Y + LE+HH + + +L++D +NI SH+S E+++E+ G + +L T
Sbjct: 521 HVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGT 580
Query: 689 DLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKV 748
D+ F + +R+L EA + +++ + D+S AK W + + +
Sbjct: 581 DMTNHFQQMKAMRQLLTLQEATID------KQKVLSLVLHCCDISHPAKQWGVHHRWTML 634
Query: 749 IFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY----DMLYRILPN 804
+ EEF+ QGD E+ G P+ DRN SQ+ F+ I P DML IL
Sbjct: 635 LLEEFFRQGDLEKELGLPFSPLCDRNN-TLVAESQICFIDFIVEPSMGVMSDMLELILAP 693
Query: 805 TKPM 808
PM
Sbjct: 694 IAPM 697
>UniRef50_Q14123 Cluster: Calcium/calmodulin-dependent 3',5'-cyclic
nucleotide phosphodiesterase 1C; n=128;
Euteleostomi|Rep: Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1C - Homo
sapiens (Human)
Length = 709
Score = 106 bits (254), Expect = 3e-21
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 253
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 254 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 313
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 314 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 366
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 367 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 425
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 426 SQVGFIDFIVEPTFTVL 442
>UniRef50_O96077 Cluster: EFPDE3; n=1; Ephydatia fluviatilis|Rep:
EFPDE3 - Ephydatia fluviatilis
Length = 1054
Score = 105 bits (253), Expect = 4e-21
Identities = 60/189 (31%), Positives = 90/189 (47%), Gaps = 3/189 (1%)
Query: 610 ALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQ-DGHNIFS 667
A ++A HD DH G TN ++ T SPLA +Y + LE+HH + +L HN
Sbjct: 670 ATYMAAAVHDFDHPGRTNAFLVATKSPLAILYNDRAVLENHHCAASWDLLTSVPEHNFLG 729
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIR-ELYRSDEAQFSWDDPSHRDLAMAIS 726
+ + K + +LATDL F L R ++ ++ W R M +
Sbjct: 730 DMEEAELKRFRFLLVEAVLATDLKMHFDLLSDFRAKVDPEEDGGIDWSSEVDRLTVMKMI 789
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
M AD+S K +E+ K+I EEFY QG++E G P +DR PE+ PA Q+ F
Sbjct: 790 MKMADISTPTKSYELHRAWTKLITEEFYQQGEQEIVLGLPPTIFLDRKHPEKLPAVQLSF 849
Query: 787 LSQICIPCY 795
+ + P +
Sbjct: 850 IQNLVSPLF 858
>UniRef50_Q24GJ8 Cluster: GAF domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: GAF domain containing
protein - Tetrahymena thermophila SB210
Length = 744
Score = 105 bits (252), Expect = 6e-21
Identities = 68/193 (35%), Positives = 109/193 (56%), Gaps = 14/193 (7%)
Query: 316 LLDVVKAIFEEMVSL--DQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEP 373
L +++A FE SL + ++ I++ + DR ++++VD + +EL S K
Sbjct: 362 LKKIIRASFEMTKSLVLNDALETIVDETCICLECDRCTVYVVDEKKNELWS-----KMAK 416
Query: 374 GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP 433
G K IRMPIN+GIAG VA + +T+NI +AY+D RFN+D D+ YK+ +ILC+P
Sbjct: 417 GT-----KNVIRMPINQGIAGFVATTKQTLNILNAYADERFNKDFDKKMNYKSRTILCVP 471
Query: 434 IKVE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRV 492
I E G+V+G +Q +NK + +F DDEA + + F + L +A YD K R
Sbjct: 472 IIDEHGRVLGAIQCINKLNG-HFTKDDEALLMVIADFSRIVLKNAINYDEQNLAHSKLRS 530
Query: 493 ALEVLSYHNTCRE 505
+ + Y N+ ++
Sbjct: 531 IVNLGIYQNSQKD 543
Score = 37.1 bits (82), Expect = 2.2
Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 5/74 (6%)
Query: 377 LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-- 434
++ E ++I + I++GIAG V ET+N + Y +F+ +VD T T LC+P+
Sbjct: 578 INEENQQITLKIDQGIAGLVFKQKETVNCFNCYHHKQFSPEVDIITQMPT---LCIPVTH 634
Query: 435 KVEGKVIGVVQMVN 448
+ + V+++VN
Sbjct: 635 PKSKEALAVLEVVN 648
>UniRef50_O96078 Cluster: EFPDE4; n=1; Ephydatia fluviatilis|Rep:
EFPDE4 - Ephydatia fluviatilis
Length = 698
Score = 104 bits (250), Expect = 1e-20
Identities = 79/284 (27%), Positives = 129/284 (45%), Gaps = 12/284 (4%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKA 605
RDLF + + F T++ Y + PYHN H V A +LK+ E + +
Sbjct: 385 RDLFSEMKIVPSVFLNFISTIESKYHSNPYHNALHAADVLLATNHLLKAKALEPI-FTQL 443
Query: 606 SSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHN 664
AL VA + HD+DH G N+++ T PLA +Y S LE+HH + +++ N
Sbjct: 444 EVFAAL-VAAIIHDVDHPGRNNQFLVSTEDPLAILYNDESVLENHHLALAFELMKDPTCN 502
Query: 665 IFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FSWDDPSHRD 720
+ I +LATD++ F L +++ L S++ D R
Sbjct: 503 FLESTCKSQKQAFRKLIIDMVLATDMSRHFKYLGQLKTLLESNKVANNGLLQLDKYHDRV 562
Query: 721 LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQ 779
+ + ADLS K + I + + I EE Y QGD+ER G IP+ P+ DR+ E+
Sbjct: 563 EVLQGLLHCADLSNQTKSFHIASQWSQRIMEESYRQGDEERKLG-IPVNPLGDRSVSIEK 621
Query: 780 PASQVGFLSQICIPCYDMLYRIL-PNTKPMYAMATKNLNRWKAR 822
QV F+ I P ++ ++ P+ + + ++W+ R
Sbjct: 622 --CQVTFIDYIVYPLWETWAELVYPDAQDIVCSLMDTRDQWQCR 663
>UniRef50_A0E1V7 Cluster: Chromosome undetermined scaffold_74, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_74,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 1007
Score = 104 bits (250), Expect = 1e-20
Identities = 89/308 (28%), Positives = 137/308 (44%), Gaps = 19/308 (6%)
Query: 500 HNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMF-RDLFD-MTQFDIT 557
H T RE + Q LD N+ F EK + + SM R+ F+ M
Sbjct: 671 HLTLREEDSQ---LDSLDFNIHLVIFITSIQIKSTVEKQRIVWSMLERNNFNQMFALPQD 727
Query: 558 TLTRFTLTVKKNYR--TVPYHNFDHGWTVAHAMYAILKS---DVKERFDYNKASSRLALF 612
L F + ++ Y PYHNFDHG V A+ +KS + ++F N ++ L
Sbjct: 728 KLINFLIEMESQYNMNNNPYHNFDHGVAVMQAVNCFIKSLTNQLDQQFFNN--ITKFCLL 785
Query: 613 VACLCHDLDHRGYTNKYMSETASPLAAMYTTST-LEHHHFNITVTILQQDGHNIFSHISS 671
++ LCHD+ H G TN Y + + S LA Y LE HH T+ IL+ D NI + S
Sbjct: 786 LSALCHDVAHTGKTNAYEANSISQLAIRYHDKVILEQHHAATTIKILRDDQTNILCNFSD 845
Query: 672 EDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAAD 731
+D++ + IL+TD+ F K+ + + S Q+ +DP L + AAD
Sbjct: 846 QDFRTFRKQLISNILSTDMQEHF----KMLKEFESRIEQYG-NDPEDLSLLCGMITHAAD 900
Query: 732 LSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM-DRNKPEEQPASQVGFLSQI 790
+ +A+ W I +E+ Q +E G P M D +K +++GF+ I
Sbjct: 901 FNGTARKWPQSRLWSDKINQEYRAQYAEEGKKGYPQQPFMKDLDKLHVMSKNEIGFIKVI 960
Query: 791 CIPCYDML 798
P Y +
Sbjct: 961 VRPLYHQM 968
>UniRef50_Q388U6 Cluster: 3', 5'-cyclic nucleotide
phosphodiesterase, putative; n=2; Trypanosoma
brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase,
putative - Trypanosoma brucei
Length = 620
Score = 104 bits (249), Expect = 1e-20
Identities = 69/241 (28%), Positives = 117/241 (48%), Gaps = 7/241 (2%)
Query: 566 VKKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
V+ Y PYHN H V H + +L K + E N ALF A + HD +H G
Sbjct: 361 VEGGYHANPYHNSMHAADVLHITHYLLSKGGLAELCKLNDRQVLAALFAAAI-HDYNHPG 419
Query: 625 YTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
N + T + A +Y S LE+ H +++ NI + S E +++ +
Sbjct: 420 INNNFSILTQTYNATLYNDRSVLENMHVASVFELMRNPALNILACFSEEHWRDFRNTVID 479
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
+LATD++ + + + S++ F+ D ++LA+A+++ AD+S +P + +
Sbjct: 480 MVLATDMSLHEKYMTQFKRRL-SEKRPFTED--CDQNLALAMALKLADISNCCRPLPLYL 536
Query: 744 KTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
K + + +EFY QGD+ER+ G P MDR P Q F++ I IP +++ LP
Sbjct: 537 KWSERVSDEFYTQGDRERSLGMSCSPFMDRQTP-MIAEGQTSFINYIFIPFLEVMAEFLP 595
Query: 804 N 804
+
Sbjct: 596 S 596
>UniRef50_Q16J23 Cluster: Camp-specific 3,5-cyclic
phosphodiesterase; n=2; Culicidae|Rep: Camp-specific
3,5-cyclic phosphodiesterase - Aedes aegypti
(Yellowfever mosquito)
Length = 872
Score = 104 bits (249), Expect = 1e-20
Identities = 73/257 (28%), Positives = 113/257 (43%), Gaps = 10/257 (3%)
Query: 548 LFDMTQFDITTLTRFTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
L D D+ + + +++ Y T PYHN H V AM+ L+ K +
Sbjct: 139 LLDHFNLDVVRVWKLFSLIEEGYHSTNPYHNSIHATDVTQAMHCFLQE--KRILENLSPL 196
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNI 665
+A + + HDLDH G ++ T++ LAA+Y TS LE+HH+ V L + G +
Sbjct: 197 EIMASLIGAVTHDLDHPGVNQPFLIATSNHLAALYENTSVLENHHWRSAVGCLLESG--V 254
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
I E+ I ILATD+ + + R+ D + HR + I
Sbjct: 255 AEQIQGIR-PELEKQISSLILATDITRQQEFISQFRDYLSHDTLDMR--NKEHRHFILQI 311
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVG 785
++ AD+S +PW+I K + EEF+ QGD ER +P+ + P Q G
Sbjct: 312 ALKCADISNPCRPWDISKKWSLKVCEEFFRQGDYERQL-NLPVTSLCDRHSTSVPKIQTG 370
Query: 786 FLSQICIPCYDMLYRIL 802
F + P D +R L
Sbjct: 371 FFKFVVTPLMDEWHRFL 387
>UniRef50_A7AR41 Cluster: 3'5'-cyclic nucleotide phosphodiesterase,
putative; n=1; Babesia bovis|Rep: 3'5'-cyclic nucleotide
phosphodiesterase, putative - Babesia bovis
Length = 777
Score = 104 bits (249), Expect = 1e-20
Identities = 76/268 (28%), Positives = 119/268 (44%), Gaps = 11/268 (4%)
Query: 555 DITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVA 614
D + + F ++ YR VPYHN HG VA + + + ++ L VA
Sbjct: 477 DRSVVVNFLYRIENQYRNVPYHNKMHGAMVAQKVLCL--ASYTGLLEHLSILDEALLMVA 534
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSED 673
L HD+ H G N + T P+A +Y TS LE++H + +L G N+F D
Sbjct: 535 ALSHDVGHPGRNNAFFVRTHHPVAQLYNDTSVLENYHAASALRVLCTPGCNLFPDC---D 591
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLS 733
Y + I ILATD F + + + D+ F++++ + R L + M AAD++
Sbjct: 592 YDYVRSQIIEHILATDTVDQFHMISQFVLSCKRDD--FTFEEYNSRILTSKMLMKAADVA 649
Query: 734 ASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICI 792
A W ++ V + EFY QG E IPI + DR E+ SQ FL +
Sbjct: 650 APTMQWANSLEWVSRLLGEFYAQG-AEEVDYCIPISALCDRQHHEQSAKSQAAFLRIVVA 708
Query: 793 PCYDMLYRI-LPNTKPMYAMATKNLNRW 819
P Y+ + + P + +N +W
Sbjct: 709 PLYEAIASLGSPEIDAIMDQLEENAEKW 736
>UniRef50_A0DF61 Cluster: Chromosome undetermined scaffold_49, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_49,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 768
Score = 103 bits (247), Expect = 2e-20
Identities = 77/285 (27%), Positives = 134/285 (47%), Gaps = 16/285 (5%)
Query: 541 IISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+ +F+ + + ++ TL F++ ++ Y+ YHN H VA++ L++ +
Sbjct: 460 LFKIFKVIQTLKITNLETLGEFSVKIESLYQNNFYHNSMHAIDVANSTAFFLQNGLSTLI 519
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQ 659
D +A+ L ++ L HD+ H G N +M+ LA ++ S LE++H + +L
Sbjct: 520 DDFQAT---CLLISSLAHDIGHPGLNNGFMTANRCRLALLFNDQSVLENYHSFLLFQVLT 576
Query: 660 QDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHR 719
Q NI ++S + K + + IL TDL F ++K + +E+ +
Sbjct: 577 QSNCNIIENLSINEIKGFRKYCLNLILDTDLTRHFQLMNKFQNYLNVNESP-----AVDQ 631
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEE 778
L M+I + AD+ AK ++ + I EEF+ QGD E ++PI PM DRN +
Sbjct: 632 QLIMSIGIKCADVGHGAKELKLHKLWSRRIVEEFFLQGDLENYL-KVPISPMCDRN--QN 688
Query: 779 QPASQVGFLSQICIPCYDMLYRILPN---TKPMYAMATKNLNRWK 820
SQ GFL I +P ++ IL N K +N+ W+
Sbjct: 689 VSKSQEGFLKAIVLPMFEAFSTILKNENIQKTCVDQVKQNIEYWQ 733
>UniRef50_A0LGQ1 Cluster: Putative PAS/PAC sensor protein; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Putative PAS/PAC
sensor protein - Syntrophobacter fumaroxidans (strain
DSM 10017 / MPOB)
Length = 535
Score = 103 bits (246), Expect = 3e-20
Identities = 60/170 (35%), Positives = 98/170 (57%), Gaps = 11/170 (6%)
Query: 317 LDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLD 376
L V E +SLD L+ R++E + A R ++FL D +EL S
Sbjct: 50 LTEVSTRLSESLSLDVLLSRLIEITTESLEAYRGTVFLHDKDTNELYSRAA--------- 100
Query: 377 LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKV 436
L +EIR+PI++GI G+V ++G+ +NI DAY+D RFN ++D+ TGYKT ++L +PIK
Sbjct: 101 LGNLIQEIRIPIHQGIVGNVFVTGQPVNIDDAYADARFNPEMDKKTGYKTRNVLAVPIKT 160
Query: 437 EGK-VIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
+ + ++GV+Q++NK+ F ++D E AL +A+ Y+ + R
Sbjct: 161 KDRQIVGVIQLLNKKSGS-FSENDLLMLEAIGGQAAAALQNAQTYEIVSR 209
Score = 84.2 bits (199), Expect = 1e-14
Identities = 58/197 (29%), Positives = 96/197 (48%), Gaps = 12/197 (6%)
Query: 302 LYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE 361
L+ +ER + IF E+ ++ L K+I E L+ A+R+ L+L D + +E
Sbjct: 217 LFQQVGKERREEAQFFKFTREIFFEL-RMESLFKKITETTATLLAAERSVLYLHDDKANE 275
Query: 362 LVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
L S + + +R P + GIAG ++GE +NIPD VD
Sbjct: 276 LWSMTTH---------ESQTVRVRFPSHLGIAGSALITGEIVNIPDTAKLPSSIFPVDIE 326
Query: 422 TGYKTISILCMPIKV-EGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
G+ S+LC PIK +GKV+GV+Q+ NK+ F DE+ EIF+ + +A+ +A L+
Sbjct: 327 PGFPAHSVLCAPIKTSQGKVVGVIQVRNKKGGP-FDRADESRLEIFAGYASIAIRNAELF 385
Query: 481 DRIMRKEQKYRVALEVL 497
+ ++ + L
Sbjct: 386 EATLKSANYFESIFRTL 402
>UniRef50_A7RXZ4 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 367
Score = 103 bits (246), Expect = 3e-20
Identities = 63/190 (33%), Positives = 91/190 (47%), Gaps = 5/190 (2%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG-HNIF 666
L+L+ A HD DH G TN ++ T S A +Y S LE+HH T+L D +N
Sbjct: 160 LSLYTAAAMHDYDHPGRTNAFLVATLSHQALLYNDRSVLENHHAAAAFTLLMSDPKYNFL 219
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
+S ++K ILATDL F L ++ E +WD + R L +
Sbjct: 220 CELSPAEFKRFRFLAIEAILATDLKRHFDILSDFNA--KTAEGGVNWDSEADRLLTLQFC 277
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
+ +D+S +K +I + I EEFY+QGD ERA G P MDR +P Q F
Sbjct: 278 IKMSDISGPSKRRDIHTLWTERIVEEFYEQGDDERARGMAVSPYMDRQQPHVAQL-QDSF 336
Query: 787 LSQICIPCYD 796
++ + P Y+
Sbjct: 337 INHLVAPLYN 346
>UniRef50_Q4SVG0 Cluster: Chromosome 1 SCAF13759, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 1
SCAF13759, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 954
Score = 102 bits (244), Expect = 5e-20
Identities = 54/163 (33%), Positives = 87/163 (53%), Gaps = 6/163 (3%)
Query: 503 CREYEVQAMLLDKEPLN--VDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--T 558
C E E+Q +L + P + + +F+ F E + KC I M+ +L + +F I
Sbjct: 558 CEEEELQEILAEVLPNSRKAEIFEFHFCDFEHSELDLVKCGIKMYYELKVVDKFHIPREV 617
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCH 618
L RF +V K YR + YHN+ HG+ V M+ +L + +R+ Y +A+ A CH
Sbjct: 618 LVRFMYSVSKGYRRITYHNWRHGFNVGQTMFTLLMTGDLKRY-YTDLEC-MAMVTAGFCH 675
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
D+DHRG N Y ++ +PLA ++ +S LE HH T+L+ +
Sbjct: 676 DIDHRGTNNLYQMKSGNPLAKLHGSSILERHHLEFGKTLLRDE 718
Score = 81.8 bits (193), Expect = 8e-14
Identities = 50/152 (32%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S+ L D+V+ I ++ +++++ + ++ ++ ADR SLF+ RN +EL + +F++
Sbjct: 51 SEVLFDLVRDI-QDNLNMEKCVFNLMRHLSFMMRADRTSLFMFRQRNGVAELATRIFNVH 109
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ D L + EI P++ GI GHVA S + +NIPD F+ VDE T Y+T S
Sbjct: 110 KDAEFDDCLVPPESEIVYPLDIGIVGHVASSKKMVNIPDVSQSPHFSGFVDELTEYQTRS 169
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDE 460
+L +PI ++ V+ NK D F DE
Sbjct: 170 VLAVPIMNGKDMVAVLMATNKLDGPSFTAKDE 201
Score = 64.5 bits (150), Expect = 1e-08
Identities = 35/126 (27%), Positives = 69/126 (54%), Gaps = 3/126 (2%)
Query: 391 GIAGHVALSGETMNIPDAYSDYRFNRDVD--EATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G NI +A D FN + + +G+ ++L +PI + +++GV
Sbjct: 387 GLPTYVAETGLICNIMNAAEDEFFNFQTEPLDESGWTIRNVLSLPIVNKKEEIVGVATFY 446
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + + +++ YH CR+ E
Sbjct: 447 NRKDGKPFDEMDETLMESLTQFLGWSMLNPDTYDKMNKLENRKDIYQDMVMYHVKCRKDE 506
Query: 508 VQAMLL 513
+Q +L+
Sbjct: 507 IQNVLV 512
>UniRef50_Q23PX5 Cluster: GAF domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: GAF domain containing
protein - Tetrahymena thermophila SB210
Length = 906
Score = 102 bits (244), Expect = 5e-20
Identities = 54/141 (38%), Positives = 84/141 (59%), Gaps = 13/141 (9%)
Query: 343 RLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGET 402
++VN DRAS+FL+D + +EL + V K IR+ I +G+ G VA +GE
Sbjct: 578 QVVNCDRASVFLIDPKRNELWTKVA-----------RHSKPIRVQIGQGLVGQVAQTGEI 626
Query: 403 MNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGK--VIGVVQMVNKRDDKYFGDDDE 460
+N+ DA+ DYRFN D D+ Y+T S+LC+PIK + + +IGV+Q +NK+D +F +DE
Sbjct: 627 LNVLDAHQDYRFNSDADKKNNYRTKSVLCLPIKDQNQSHIIGVLQAINKKDGDFFTKEDE 686
Query: 461 AAFEIFSTFFGLALHHARLYD 481
+ I S L ++ +D
Sbjct: 687 SLLIIISQLATAVLRNSLYHD 707
Score = 40.3 bits (90), Expect = 0.23
Identities = 45/191 (23%), Positives = 87/191 (45%), Gaps = 14/191 (7%)
Query: 302 LYVDKKRE-RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
LY D++ RN L++ + +E S+ LI R + +A +++ D + +
Sbjct: 704 LYHDEREAYRNNLKSLVNTGIDLSKEK-SIKTLIVRSTAILIDKFDVQQARIWIYDLQQN 762
Query: 361 ELVSTVFD----LKFEPGLDLDMEK-KEIRMPINRGIAGHVALSGETMNIPDAYSDYRFN 415
+L+ D L G ++ E KE + +++GI GH+ + +T N +AY FN
Sbjct: 763 QLIRYFVDDDQVLSILQGQAINEEVIKEEKCQLDQGIIGHIFQTCKTENFLNAYQHPLFN 822
Query: 416 RDVDEATGYKTISILCM----PI-KVEGKVIGVVQMVNKR--DDKYFGDDDEAAFEIFST 468
+D T I+ + PI + K IGV+Q +N + + F + + +I +
Sbjct: 823 NSIDLNTSLPVITTIIKAQLDPIDQSVQKKIGVLQCINPKGLETLVFSQNSQGGKDIPNA 882
Query: 469 FFGLALHHARL 479
F+ + + +L
Sbjct: 883 FYDILEYFCQL 893
>UniRef50_UPI00015B5210 Cluster: PREDICTED: similar to
ENSANGP00000018818; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000018818 - Nasonia
vitripennis
Length = 849
Score = 101 bits (243), Expect = 7e-20
Identities = 76/272 (27%), Positives = 134/272 (49%), Gaps = 16/272 (5%)
Query: 555 DITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD-VKERFDYNKASSRLALF 612
D TL + ++ NY + V YHN H V A ++SD +++ D +A
Sbjct: 557 DERTLQNWLTIIEANYNSHVSYHNSTHATDVLQACARFMRSDRIQQILD---PLDEVAAL 613
Query: 613 VACLCHDLDHRGYTNKYMSETASPLAAMYTTST-LEHHHFNITVTI-LQQDGHNIFSHIS 670
+A HD+ H G +++++ T++ LA +Y T LE HH +T + L D NIF ++
Sbjct: 614 LAAAAHDIGHPGKSSQFLCNTSNKLAILYNDLTVLESHHSALTFKVTLSDDNVNIFKNLH 673
Query: 671 SEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAA 730
++ YK + I ILAT++ F +L + L+ D + F P + L + + A
Sbjct: 674 ADVYKSMRQNIIDMILATEMTKHFEHLARFVNLF--DTSAFLL--PENVTLTKRMMIKCA 729
Query: 731 DLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI--PMMDRNKPEEQPASQVGFLS 788
D+S +P+ + ++ + I EE++DQ D+E+ ++P+ PM DR P SQ+GF+
Sbjct: 730 DVSNPTRPFRLYVEWTRRIAEEYFDQTDEEKKK-KLPVVMPMFDR-ACCCIPKSQIGFVE 787
Query: 789 QICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
I + + + M ++N +WK
Sbjct: 788 YIINDMME-AWDAFIDMPEMVGYMSENYMKWK 818
>UniRef50_UPI00006CF33D Cluster: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein; n=1; Tetrahymena
thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein - Tetrahymena
thermophila SB210
Length = 354
Score = 101 bits (241), Expect = 1e-19
Identities = 80/300 (26%), Positives = 146/300 (48%), Gaps = 17/300 (5%)
Query: 536 EKCKCIISMFRDLFDMTQFDITTLTRFT-----LTVKKNYRTVPYHNFDHGWTVAHAMYA 590
+K K I MF+D+ D+ + +F L+ K +YR P+HNFDHG TVAH +Y
Sbjct: 52 KKFKVAILMFKDI-DLLGILGQSSNKFQNFLVQLSNKYDYRGNPFHNFDHGITVAHGIYY 110
Query: 591 ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHH 649
I+K + + + + +L + LCHD+DH G++N Y + + S L +Y S LE H
Sbjct: 111 IIKQGITNK--HLNQLEKFSLLFSALCHDVDHTGHSNAYETNSKSELFTLYGNESPLEKH 168
Query: 650 HFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRE-LYRSDE 708
H+ T+ I Q G +F I + + +I+H ILATD++ +++ +E L +
Sbjct: 169 HYAQTIQIADQCG--LFDSIPQDQLVIMKKYIQHNILATDMSKHNQIMNEFKENLPSLLK 226
Query: 709 AQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI 768
+ + +L A+ + AAD+ A + + I + I +EF Q + E+ +P+
Sbjct: 227 EDLAITEQQKINLCGAL-VHAADIGAPTRDFSISKEWSLRIAKEFTAQLELEQ-QNNLPV 284
Query: 769 P--MMDRNKPEEQPASQVGFLSQICIPCYDMLYRI-LPNTKPMYAMATKNLNRWKARADK 825
D +K +++GF++ P + + + + + +N+ WK ++
Sbjct: 285 TPFYKDLDKYLTLATNEIGFINFFIKPFWVQIEQFGQGKLQQVSKNIEQNIQNWKQEKEQ 344
>UniRef50_A0EGK4 Cluster: Chromosome undetermined scaffold_95, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_95,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 756
Score = 101 bits (241), Expect = 1e-19
Identities = 74/247 (29%), Positives = 117/247 (47%), Gaps = 13/247 (5%)
Query: 562 FTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLD 621
F L + Y YHN H VA++ L + + + D + + L V+ L HDL
Sbjct: 470 FALKLFTQYHNNLYHNSLHALDVANSTAFFLNNGLDAQLDEFEFA---CLIVSSLAHDLG 526
Query: 622 HRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGF 680
H G N +M+ LA +Y S LE++H + ILQQ+ N+ ++ D K +
Sbjct: 527 HPGLNNGFMTTNRCKLALLYNDQSVLENYHSFLLFQILQQEQFNLIQNLGLPDQKGFRKY 586
Query: 681 IRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWE 740
+ IL TDL F +++ + E+Q + + L M+I + AD+ AK +
Sbjct: 587 CLNLILDTDLTKHFQLMNRFQNYLDLSESQV-----TDKSLVMSICIKCADVGHGAKQLK 641
Query: 741 IQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIPCYDMLY 799
+ + I EEF+ QGD E ++PI PM DR + SQ GFL I +P ++
Sbjct: 642 MHKLWSRRIIEEFFLQGDLEDYL-KVPISPMCDRK--QSVVKSQEGFLKAIVLPMFNAFA 698
Query: 800 RILPNTK 806
++L N K
Sbjct: 699 KLLQNEK 705
>UniRef50_A2GFY4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Trichomonas vaginalis G3
Length = 457
Score = 100 bits (239), Expect = 2e-19
Identities = 72/275 (26%), Positives = 114/275 (41%), Gaps = 11/275 (4%)
Query: 522 FADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFD 579
+ +F RFD + ++ +F + +Q DI T RF ++ Y VPYHN+
Sbjct: 156 YQNFMFTIERFDNDSLFEIVVCLFSQIIKRSQLDIDFETFVRFLYKIRSLYNDVPYHNWR 215
Query: 580 HGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAA 639
H +Y L E F + +L A +CHD+ H G +N + + S A
Sbjct: 216 HACDACQFVYFALLQKPIEHFI--QPIDYFSLMTAAICHDVGHNGRSNDFHRQVNSKYAQ 273
Query: 640 MYTTST--LEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNL 697
++ LE+HH IT+ L + + E + F+ + ILATD++ +
Sbjct: 274 ESGSNQPPLEYHHQKITIEFLSNEFSKSIQTFNDETRRIYFKFVSNIILATDMSKHQDYI 333
Query: 698 DKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQG 757
+ S + D R LA M ADLS + +P+ + EE+Y QG
Sbjct: 334 VSFNNIAGSYK-----DTEDERLLACQAIMKLADLSNTCRPFGEAATMSAQLQEEWYTQG 388
Query: 758 DKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICI 792
D++ G DRN P QVGF + +
Sbjct: 389 DEQLKRGLEITKGFDRNNKTPLPQGQVGFYKYVTL 423
>UniRef50_A0CB76 Cluster: Chromosome undetermined scaffold_163,
whole genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_163,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 619
Score = 100 bits (239), Expect = 2e-19
Identities = 70/254 (27%), Positives = 116/254 (45%), Gaps = 13/254 (5%)
Query: 575 YHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSET 633
YHN H + V H +Y + K + KE K + L A HD DH G N ++S T
Sbjct: 366 YHNVIHAFDVTHTVYFFIQKCNFKEIGKLTKIDYSILLMSAA-AHDADHPGLNNIFLSNT 424
Query: 634 ASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAA 692
LA Y S LE HH +++ ++ H + +D+K + IL+TD A
Sbjct: 425 RHDLAMTYNDKSPLEQHHAATLFRYIRET--DLLVHFTLQDFKYFREKSINMILSTDNAM 482
Query: 693 FFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS--MTAADLSASAKPWEIQIKTVKVIF 750
+ +K++ S++ DP +D + + AAD+S KP + + +
Sbjct: 483 HGKDYNKLKARLASNDF-----DPGSKDKGICFDTLLHAADISNPFKPMKNYEQWTFRVL 537
Query: 751 EEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYA 810
EF+ QGD+E+ G +P+ M+ + SQ+GF+ + +P Y+ L +ILP
Sbjct: 538 GEFWHQGDREKELG-LPVTMLCDRRTTNVAKSQIGFIDFMVLPYYNTLSQILPQLSEFIE 596
Query: 811 MATKNLNRWKARAD 824
T+N W + +
Sbjct: 597 QITENKKAWAEKIE 610
>UniRef50_Q1IKE0 Cluster: Diguanylate cyclase with GAF sensor; n=1;
Acidobacteria bacterium Ellin345|Rep: Diguanylate
cyclase with GAF sensor - Acidobacteria bacterium
(strain Ellin345)
Length = 362
Score = 99 bits (238), Expect = 3e-19
Identities = 65/225 (28%), Positives = 117/225 (52%), Gaps = 13/225 (5%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
D KR+ DV KA+ + +LD +++ I+E D SL +VD SEL
Sbjct: 20 DHKRQLQELGIFHDVAKALTSSL-NLDSILQTIMEKMAEYFRPDTWSLLMVDEEKSELYF 78
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
+ G D K +R+ + GIAG VA GE++ +PD Y+D RF + +DE T +
Sbjct: 79 AI-----AVG-DAAEALKTVRLKLGEGIAGWVAQHGESLLVPDVYTDPRFAKRIDEMTKW 132
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
+T SI+C+P+K + +V+GV+Q++N D + FG ++ + + + +A+ +AR ++I
Sbjct: 133 QTRSIICIPLKSKHRVLGVIQLINV-DMQGFGGNEMLLLQALADYAAIAIDNARAVEKI- 190
Query: 485 RKEQKYRVALEVLSYHNTCREYE-VQAMLLDKEPLNVDFADFYLD 528
Q+ + + +N Y+ ++A + +F+ +LD
Sbjct: 191 ---QELTITDDCTGLYNARHLYKTLEAEVYRSTRFGYEFSILFLD 232
>UniRef50_Q4T098 Cluster: Chromosome undetermined SCAF11274, whole
genome shotgun sequence; n=4; Tetraodontidae|Rep:
Chromosome undetermined SCAF11274, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 601
Score = 99.5 bits (237), Expect = 4e-19
Identities = 58/195 (29%), Positives = 100/195 (51%), Gaps = 10/195 (5%)
Query: 610 ALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTL-EHHHFNITVTILQ-QDGHNIFS 667
A A HD +H G TN + +T S ++ +Y + E+HH + +LQ D NI S
Sbjct: 268 ATIFAAAIHDYEHTGTTNNFHIQTRSDISLLYNDHAVQENHHVSAVYRLLQTNDDTNILS 327
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
++S +D++E+ + +LATD++ F + ++ L + EA + A+++ +
Sbjct: 328 NLSKDDWRELRALVVEMVLATDMSCHFEQIKVMKGLLQQPEA-------IDKAKALSLLL 380
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
AD+S AKPW + + + EEF+ QGDKE G P+ DR K SQ+GF+
Sbjct: 381 HTADISHPAKPWSLHHRWTFSLLEEFFRQGDKEVELGLPFSPLCDR-KSTMVAQSQIGFI 439
Query: 788 SQICIPCYDMLYRIL 802
I P + ++ ++
Sbjct: 440 DFIVEPTFTVMTEMI 454
>UniRef50_Q7M8J3 Cluster: RESPONSE REGULATOR PROTEIN-CheY-like nd an
HD-GYP domain; n=2; Wolinella succinogenes|Rep: RESPONSE
REGULATOR PROTEIN-CheY-like nd an HD-GYP domain -
Wolinella succinogenes
Length = 637
Score = 99.5 bits (237), Expect = 4e-19
Identities = 66/182 (36%), Positives = 103/182 (56%), Gaps = 16/182 (8%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
+ + V I +E SL++L+ + A+++V ADR +++++D EL + K G+
Sbjct: 282 IFECVGKIAQER-SLERLLLLMAGMARQIVTADRCTIWMIDREKGELWT-----KIAHGI 335
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI- 434
D I++P+ GIAG+VA GET+ I D Y+D RFN +VD+ TGY T SI+ +PI
Sbjct: 336 DA------IKIPLGSGIAGYVAQKGETLVINDPYNDPRFNPEVDKKTGYLTRSIIALPIF 389
Query: 435 KVEGKVIGVVQMVNKRD-DKYFGDDDEAAFEIFSTFFGLALHHARLYDRI--MRKEQKYR 491
EG++IG Q +NK + F +D + +T+ G AL A LY I +KE Y
Sbjct: 390 NSEGEIIGAYQAINKMTLSQGFSQEDAKYLTLAATYTGSALESAMLYAEIEETQKEIIYT 449
Query: 492 VA 493
+A
Sbjct: 450 MA 451
>UniRef50_A0YPV9 Cluster: Adenylate/Guanylate Cyclase; n=1; Lyngbya
sp. PCC 8106|Rep: Adenylate/Guanylate Cyclase - Lyngbya
sp. PCC 8106
Length = 1159
Score = 99.5 bits (237), Expect = 4e-19
Identities = 54/156 (34%), Positives = 97/156 (62%), Gaps = 12/156 (7%)
Query: 312 MSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKF 371
+S+ L + +++ + +++I+R+++ A++L+NADR++L+L D R EL + + F
Sbjct: 574 ISEALSEATRSVSYSSLDTEEIIQRVMDAAKKLMNADRSTLWLFDARTDELWTKI---PF 630
Query: 372 EPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIP-DAYS--DYRFNRDVDEATGYKTIS 428
E G KEIR+ + +G AG VA +GE +NIP D Y+ D + D+ TGY+T S
Sbjct: 631 ENG-----SVKEIRIKVGQGFAGQVAQTGEELNIPFDLYNHPDSNTAKTTDQKTGYRTCS 685
Query: 429 ILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAF 463
+LCMP+ EG+++GV Q++N+R + + D + +
Sbjct: 686 LLCMPVHNPEGELLGVTQLINRRKPGQYPEYDPSTW 721
Score = 84.6 bits (200), Expect = 1e-14
Identities = 46/124 (37%), Positives = 80/124 (64%), Gaps = 11/124 (8%)
Query: 330 LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
+D++IKR+++ A+ L+NADR++L+++D + + T + F+ D ++E+R+ +
Sbjct: 981 IDEIIKRVMDAAKSLMNADRSTLWILDRNQPDELWT--KVTFD-----DSSQRELRIKVG 1033
Query: 390 RGIAGHVALSGETMNIP-DAYS--DYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQ 445
+G AG VA G +NIP D Y D ++ D+ TGY+T S+LCMP+ +G +IGV Q
Sbjct: 1034 QGYAGKVAQMGIPLNIPFDLYDYPDSETAKNTDKKTGYRTCSLLCMPVFNPDGDLIGVTQ 1093
Query: 446 MVNK 449
++NK
Sbjct: 1094 LINK 1097
Score = 74.9 bits (176), Expect = 9e-12
Identities = 49/130 (37%), Positives = 75/130 (57%), Gaps = 13/130 (10%)
Query: 324 FEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKE 383
F+E+ LD ++ I + +NADR ++FL+D +E S V + + L E
Sbjct: 788 FDEI--LDATLRSITLKTGKSLNADRTTIFLLDEEQNEFWSIVAESEENRSL-------E 838
Query: 384 IRMPINRGIAGHVALSGETMNIP-DAYSDYRFN--RDVDEATGYKTISILCMPIKVE-GK 439
IR+P N+GI G VA + +T+NIP D Y D R +D D+ GY+T S+L +P+ E G
Sbjct: 839 IRVPANKGIVGEVAATKKTINIPYDFYDDSRSETAKDQDKKNGYRTYSMLALPLLNELGD 898
Query: 440 VIGVVQMVNK 449
++ VVQ +NK
Sbjct: 899 LVAVVQAINK 908
>UniRef50_A5K0J4 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
phosphodiesterase, putative - Plasmodium vivax
Length = 1001
Score = 99.5 bits (237), Expect = 4e-19
Identities = 71/253 (28%), Positives = 110/253 (43%), Gaps = 7/253 (2%)
Query: 554 FDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALF 612
FD L F L + Y VPYHN H VAH ++L D+ + A L
Sbjct: 705 FDKEKLKNFLLKMHSLYNDVPYHNSLHAAQVAHFSKSMLFLLDINHKIP---AIDEFCLH 761
Query: 613 VACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISS 671
V+ LCHD+ H G N ++ + + LA Y S LE++H ++ L++ NIF +
Sbjct: 762 VSSLCHDVGHPGLNNYFLINSENNLALTYNDNSVLENYHCSLVFKTLKEKNCNIFENYPY 821
Query: 672 EDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAAD 731
+ I IL+TD+ F + R + D + + ++ + AAD
Sbjct: 822 NIFTTCKKNIIRAILSTDMKNHFEYISNFRTSKEFIDLDILTSDQTWQIFSLILK--AAD 879
Query: 732 LSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQIC 791
+ + W + I EEFY QG E++ + D N ++ SQ+GFL +C
Sbjct: 880 IGHATLDWNKHYEWTMKINEEFYLQGLLEKSLNMPNSFLCDINSIDKLANSQIGFLKHLC 939
Query: 792 IPCYDMLYRILPN 804
IP + L I N
Sbjct: 940 IPLFSELNSISRN 952
>UniRef50_A0EBQ7 Cluster: Chromosome undetermined scaffold_88, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_88,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 744
Score = 99.5 bits (237), Expect = 4e-19
Identities = 71/244 (29%), Positives = 111/244 (45%), Gaps = 10/244 (4%)
Query: 562 FTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLD 621
F ++ Y PYHN H VA++ L++ ++ + L ++ L HD+
Sbjct: 452 FCHRIESFYMQNPYHNSIHAMDVANSASFFLENGLEVT-----PFEQCCLIISALSHDVG 506
Query: 622 HRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGF 680
H G N ++ + S A +Y S LE +H ++ +L+ + NI +I+ DYK +
Sbjct: 507 HPGLNNGFLVASQSKQALIYNDQSVLESYHASLMFHVLKDEKANILKNINDVDYKGFRKY 566
Query: 681 IRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWE 740
+ IL TDL FP L+K + S D + L ++I++ AD+ AK
Sbjct: 567 CLNLILDTDLQKHFPLLNKFKNFLAL--GSDSQSDEQTKLLILSIAIKCADVGHGAKQLN 624
Query: 741 IQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYR 800
+ + I EEF+ QGD E G PM DR+ + SQ GFL I P +D
Sbjct: 625 LHKIWSRRIIEEFFLQGDLEAQVGIQVTPMCDRS--QSVTKSQEGFLKAIVWPLFDAFGE 682
Query: 801 ILPN 804
L N
Sbjct: 683 FLKN 686
>UniRef50_A2DM90 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=2; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Trichomonas vaginalis G3
Length = 457
Score = 99.1 bits (236), Expect = 5e-19
Identities = 72/252 (28%), Positives = 111/252 (44%), Gaps = 15/252 (5%)
Query: 541 IISMFRDLFDMTQF--DITTLTRFTLTVKKNYRTVPYHNFDHGWTVAH-AMYAILKSDVK 597
I S F + T D + F + + +Y VPYHN+ H Y I V+
Sbjct: 175 IFSFFYSILKDTDIPVDWNEIIAFIVEAQSHYNNVPYHNWRHATDATQFVFYLITMPHVE 234
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLA--AMYTTSTLEHHHFNITV 655
E R AL ++ +CHDL+H G+TN Y + S + A LE+HH +
Sbjct: 235 EMLP---PLDRFALLLSVICHDLEHNGHTNDYHRKVNSEFSQEAGPDLPPLENHHQKLAK 291
Query: 656 TILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDD 715
++Q+ H++ E + + FI I +TD+ L+KI +
Sbjct: 292 VLIQKHLKYTLEHLTDEQKENMFRFITEIIFSTDMGKHKFYLEKIVANIGKFDGSIEL-- 349
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM-MDRN 774
R L M ADLS + +P++ K K + +E++ QGD E+ G +PI MDR+
Sbjct: 350 ---RILTCQAIMKLADLSNTCRPFDDSCKMAKRLNDEWFIQGDDEKKLG-LPISNGMDRD 405
Query: 775 KPEEQPASQVGF 786
P P Q+GF
Sbjct: 406 HPTPLPKGQIGF 417
>UniRef50_A0D565 Cluster: Chromosome undetermined scaffold_38, whole
genome shotgun sequence; n=5; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_38,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 964
Score = 99.1 bits (236), Expect = 5e-19
Identities = 82/287 (28%), Positives = 130/287 (45%), Gaps = 11/287 (3%)
Query: 519 NVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRF--TLTVKKNYRTVP 574
N+D DF + P+ D EK K + S+ R + + I+ L F L K N R
Sbjct: 654 NIDNLDFNILPYSTDWLEKQKVVFSILRRNNFIEDYRISQDALCSFLCALEYKYNKRGNQ 713
Query: 575 YHNFDHGWTVAHAMYAILKSDVKERFDYN-KASSRLALFVACLCHDLDHRGYTNKYMSET 633
+HN+DHG TV +AI +K ++ + ++ L ++ LCHD+ H G TN + +
Sbjct: 714 FHNYDHGVTVMQCTHAISLEIMKTQYAHLLNQFTKFVLILSGLCHDVSHTGRTNIFEINS 773
Query: 634 ASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAA 692
S L Y S LE HH ++ +L NI + +S ++++ IL TD+
Sbjct: 774 LSNLTIRYHDRSVLEQHHAATSIKLLCAPSTNIIPNFTSVEFRDFRKLFISNILYTDITE 833
Query: 693 FFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEE 752
F NL K E R E F +D M I +D + AKP+ + + + E
Sbjct: 834 HF-NLIKNFEA-RIKELNFGTEDDIKLMTGMIIH--TSDFTGGAKPFNLSREWSTRVNME 889
Query: 753 FYDQGDKERAAGRIPIP-MMDRNKPEEQPASQVGFLSQICIPCYDML 798
F +Q + E G +P M D ++ S+VGF I P + ++
Sbjct: 890 FQEQYNLEGKFGYPQLPYMKDLDQQPIMAKSEVGFFKFIVRPLWSIM 936
>UniRef50_Q8YVS0 Cluster: Adenylate cyclase; n=6; Cyanobacteria|Rep:
Adenylate cyclase - Anabaena sp. (strain PCC 7120)
Length = 860
Score = 98.7 bits (235), Expect = 6e-19
Identities = 69/219 (31%), Positives = 119/219 (54%), Gaps = 32/219 (14%)
Query: 303 YVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSEL 362
Y+ +++R + ++ VK++ + + L+ +KR+++ A+ L+NADR++L+L+D EL
Sbjct: 246 YIATQKQRAAAA-MMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHEL 304
Query: 363 VSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIP-DAYS--DYRFNRDVD 419
+ + + G KE+R+PI +G AG VA SG+ +NIP D Y D + +D
Sbjct: 305 WTKITQ---DNG-----STKELRVPIGKGFAGIVAASGQKLNIPFDLYDHPDSATAKQID 356
Query: 420 EATGYKTISILCMPI-KVEGKVIGVVQMVNKRD-------------------DKYFGDDD 459
+ GY+T S+LCMP+ + ++IGV Q+VNK+ F +D
Sbjct: 357 QQNGYRTCSLLCMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRND 416
Query: 460 EAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS 498
E E F+ G+AL +A+L+ + ++EQ R L LS
Sbjct: 417 EEFMEAFNIQAGVALQNAQLFATVKQQEQMQRDILRSLS 455
Score = 69.3 bits (162), Expect = 4e-10
Identities = 45/124 (36%), Positives = 73/124 (58%), Gaps = 11/124 (8%)
Query: 330 LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
L ++++ I L+ ADR ++FL+D EL S V + + L EIR+P +
Sbjct: 84 LQEMLQSITLKTGELLGADRTTIFLLDEEKQELWSIVAAGEGDRSL-------EIRIPAD 136
Query: 390 RGIAGHVALSGETMNIP-DAYSDYR--FNRDVDEATGYKTISILCMPIKVE-GKVIGVVQ 445
+GIAG VA + +NIP D Y D R F + ++ TGY+T ++L +P+ E G+++ VVQ
Sbjct: 137 KGIAGEVATFKQVVNIPFDFYHDPRSIFAQKQEKITGYRTYTMLALPLLSEQGRLVAVVQ 196
Query: 446 MVNK 449
++NK
Sbjct: 197 LLNK 200
>UniRef50_A3FQ29 Cluster: CGMP phosphodiesterase A4; n=2;
Cryptosporidium|Rep: CGMP phosphodiesterase A4 -
Cryptosporidium parvum Iowa II
Length = 997
Score = 98.3 bits (234), Expect = 8e-19
Identities = 79/277 (28%), Positives = 124/277 (44%), Gaps = 12/277 (4%)
Query: 555 DITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVA 614
+I+ F + Y YHN HG V H AI S + + RLA +A
Sbjct: 704 NISKFNIFFRELNIRYLNNKYHNELHGTNVCHL--AICLSRATGLWSHLDTVERLASVIA 761
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSED 673
L HD+ H G T+ ++ + LA Y S LE H ++T I+ G + S D
Sbjct: 762 SLGHDVGHIGRTSNFLVNSRHMLAINYNDRSVLEMFHASLTFRIIYYYGGGAADFLQSWD 821
Query: 674 ---YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAA 730
+KE + IL TD+ F + + R + R + D R + + AA
Sbjct: 822 AELHKEFRRIVIELILETDMHRHFECVSRFR-VRRQAVDWDPYGDAQDRLMLARTCLKAA 880
Query: 731 DLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQ 789
D+ A W K + + EEF+ QGD+E+A +PI P+ DR + + P SQVGFL+
Sbjct: 881 DIGHGALKWNQHYKWCRSVVEEFFLQGDEEKALS-LPISPICDR-ESTDVPKSQVGFLNF 938
Query: 790 ICIPCYDML--YRILPNTKPMYAMATKNLNRWKARAD 824
+C+P + L + + + +N+N W+ A+
Sbjct: 939 VCLPLFQELCYVDVEGDVRRCIDRILENINNWEDIAE 975
>UniRef50_A0NF29 Cluster: ENSANGP00000029810; n=2;
Endopterygota|Rep: ENSANGP00000029810 - Anopheles
gambiae str. PEST
Length = 144
Score = 98.3 bits (234), Expect = 8e-19
Identities = 57/121 (47%), Positives = 77/121 (63%), Gaps = 8/121 (6%)
Query: 330 LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
L QL++ ++ A+ L A+R SLFL+D ELVS VFD G + KEIR+
Sbjct: 7 LGQLLRGVMTEAKELAAAERCSLFLLDKHTGELVSKVFD-----GNEAS---KEIRIESG 58
Query: 390 RGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNK 449
+GIAG+VA +G+ +NI +AY F + VDE+TG+KT +ILC PI E VIGV Q+ NK
Sbjct: 59 KGIAGYVAQTGKLLNIRNAYQHPLFYKGVDESTGFKTRNILCFPICDEEGVIGVAQLCNK 118
Query: 450 R 450
R
Sbjct: 119 R 119
>UniRef50_A0WBQ4 Cluster: Diguanylate cyclase with GAF sensor; n=2;
Desulfuromonadales|Rep: Diguanylate cyclase with GAF
sensor - Geobacter lovleyi SZ
Length = 361
Score = 97.9 bits (233), Expect = 1e-18
Identities = 66/217 (30%), Positives = 109/217 (50%), Gaps = 10/217 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL++ K + + L ++++ I+ +RL+ SL LVD +EL F++ P
Sbjct: 26 LLEIGKTLISSL-ELREVLQSIMSQVERLLQPKTWSLLLVDEETNELC---FEIAVSP-- 79
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
+ E K IR+ + GIAG VA +G+ + IPD D RF V E Y SILC P+K
Sbjct: 80 -VAQELKGIRLKMGEGIAGWVAQTGQPLLIPDVSQDPRFANHVAEEVEYPVSSILCAPLK 138
Query: 436 VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR-KEQKYRVAL 494
+ +V+GV++++N ++ F DDD + F +A+ +AR Y R+ L
Sbjct: 139 IRDRVLGVIELINTLGERTFDDDDLPLLGAVADFAAIAIDNARNYRRVSELVVTDDLTGL 198
Query: 495 EVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFR 531
+ + EYE++ K +++ F D LD F+
Sbjct: 199 HNARHFHELLEYELERSRRYKSQVSLLFFD--LDHFK 233
>UniRef50_Q6NNF2 Cluster: SD02170p; n=9; Diptera|Rep: SD02170p -
Drosophila melanogaster (Fruit fly)
Length = 914
Score = 97.9 bits (233), Expect = 1e-18
Identities = 88/289 (30%), Positives = 134/289 (46%), Gaps = 15/289 (5%)
Query: 512 LLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFR--DLFDMTQFDITTLTRFTLTVKKN 569
LLD E L+ DF F L+ D + MFR D+F D + ++ +
Sbjct: 575 LLD-ESLSWDFDIFKLEEIT-DYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAH 632
Query: 570 YR-TVPYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTN 627
YR + YHN H V A A I + K+ ++ AL +A HD+DH G ++
Sbjct: 633 YRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATAL-IAAAAHDVDHPGRSS 691
Query: 628 KYMSETASPLAAMYTTST-LEHHHFNITVTI-LQQDGHNIFSHISSEDYKEILGFIRHCI 685
++ + LA +Y T LE+HH IT + L D NIF ++ E YK I I
Sbjct: 692 AFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMI 751
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQ--FSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
LAT++ F +L K ++ +E + D L + + AD+S A+P + I
Sbjct: 752 LATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCI 811
Query: 744 KTVKVIFEEFYDQGDKERAAGRIPI--PMMDRNKPEEQPASQVGFLSQI 790
+ + I EE++ Q D+E+ +PI PM DR P SQ+GF+ I
Sbjct: 812 EWARRIAEEYFMQTDEEKQR-HLPIVMPMFDR-ATCSIPKSQIGFIEYI 858
>UniRef50_A0CG66 Cluster: Chromosome undetermined scaffold_179, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_179, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 1056
Score = 97.9 bits (233), Expect = 1e-18
Identities = 76/279 (27%), Positives = 129/279 (46%), Gaps = 13/279 (4%)
Query: 530 FRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNY--RTVPYHNFDHGWTVA 585
F + + K K + + + + +D+ L +F V++ Y R P+HNFDHG TV
Sbjct: 745 FSYKDNMKTKLVYHIIKKNDWIENYDMNRDVLMKFIKEVERKYNKRKNPFHNFDHGITVM 804
Query: 586 HAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-S 644
+ + + +Y A ++ LCHD+ H G TN++ + S LA Y S
Sbjct: 805 QSCNFLCS--LPRAHEYISEIVYFATVISGLCHDISHTGRTNQFEINSKSKLATRYLDKS 862
Query: 645 TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNL----DKI 700
LE+HH +T+ +L+QD +NI +++ED + IL TD+ F + ++
Sbjct: 863 PLENHHAAVTLKLLKQDKYNILQGLNAEDLAIFRQTLIENILFTDIKQHFGLIKDFEQRV 922
Query: 701 RELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKE 760
+E + E F D + L + + +D S +AK +E+ + + EF Q D+E
Sbjct: 923 KEGKENQERVFGQVDGDVK-LFTGMIVHTSDFSGAAKVFELSKAWSEKVNMEFQAQFDEE 981
Query: 761 RAAGRIPIPMM-DRNKPEEQPASQVGFLSQICIPCYDML 798
I P M D +K E +++GF I P + L
Sbjct: 982 GTRKLISTPFMKDLDKQEIMAKNEMGFFKVIVRPLWASL 1020
>UniRef50_UPI0000E7FF0E Cluster: PREDICTED: similar to cAMP
phosphodiesterase PDE7, partial; n=1; Gallus gallus|Rep:
PREDICTED: similar to cAMP phosphodiesterase PDE7,
partial - Gallus gallus
Length = 482
Score = 97.1 bits (231), Expect = 2e-18
Identities = 69/227 (30%), Positives = 112/227 (49%), Gaps = 9/227 (3%)
Query: 566 VKKNYRTV-PYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
V+++Y + PYHN H V AM+ LK + K L+L +A HDLDH G
Sbjct: 2 VQEDYHSQNPYHNAVHAADVTQAMHCYLK-EPKLSESLTPWDVLLSL-IAAATHDLDHPG 59
Query: 625 YTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
++ +T LA +Y TS LE+HH+ V +L++ G +F+H+S E+ + + I
Sbjct: 60 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFAHMSLENRQLMESQIGD 117
Query: 684 CILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQI 743
ILATD++ L R D +D +HR + +++ AD+ + WE+
Sbjct: 118 LILATDISQQNEYLSMFRS--HLDRGDLCLEDANHRHFILQMALKCADICNPCRTWELSK 175
Query: 744 KTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQI 790
+ + + EEF+ QGD E+ P+ DR + E Q+G S +
Sbjct: 176 QWSEKVTEEFFHQGDIEKKYHLGVSPLCDR-QTETIANIQIGNRSSV 221
Score = 91.5 bits (217), Expect = 1e-16
Identities = 56/188 (29%), Positives = 95/188 (50%), Gaps = 6/188 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFS 667
L +A HDLDH G ++ +T LA +Y TS LE+HH+ V +L++ G +F+
Sbjct: 241 LLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFA 298
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
H+S E+ + + I ILATD++ L R D +D +HR + +++
Sbjct: 299 HMSLENRQLMESQIGDLILATDISQQNEYLSMFRS--HLDRGDLCLEDANHRHFILQMAL 356
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
AD+ + WE+ + + + EEF+ QGD E+ P+ DR + E Q+GF+
Sbjct: 357 KCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR-QTETIANIQIGFM 415
Query: 788 SQICIPCY 795
+ + P +
Sbjct: 416 TYLVEPLF 423
>UniRef50_Q2V2M6 Cluster: CGMP-specific phosphodiesterase; n=3;
Plasmodium|Rep: CGMP-specific phosphodiesterase -
Plasmodium falciparum
Length = 884
Score = 97.1 bits (231), Expect = 2e-18
Identities = 72/276 (26%), Positives = 121/276 (43%), Gaps = 16/276 (5%)
Query: 554 FDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALF 612
FD L +F + Y +PYH H VAH ++L D+ + A L
Sbjct: 588 FDKEKLKKFLFRICSYYNDIPYHTSLHAAQVAHFSKSMLFMLDMNHKIS---AIDEFCLH 644
Query: 613 VACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISS 671
++ LCHD H G N ++ + + LA Y S LE++H ++ L+ +NIF H
Sbjct: 645 ISSLCHDTGHPGLNNYFLINSENNLALTYNDNSVLENYHCSLLFKTLKNPNYNIFEHYPY 704
Query: 672 EDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL--AMAISMTA 729
+ I IL+TD+ F + +R+ + +D+ S+ + + + A
Sbjct: 705 HIFISCKKNIIKAILSTDMKNHFEYISD----FRTSKEFIDYDNLSNDQIWQIFCLILKA 760
Query: 730 ADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQ 789
+D+ S W ++ I EEFY QG E++ + D N + SQ+ FL
Sbjct: 761 SDIGHSTLEWNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINTMNKLALSQIDFLKH 820
Query: 790 ICIPCYDMLYRILPNTKPMYAMATK----NLNRWKA 821
+CIP ++ L I N +Y + N+ RW++
Sbjct: 821 LCIPLFNELNYICKN-NDVYTHCIQPIENNIERWES 855
>UniRef50_A7SVX8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 844
Score = 97.1 bits (231), Expect = 2e-18
Identities = 78/279 (27%), Positives = 129/279 (46%), Gaps = 24/279 (8%)
Query: 566 VKKNY-RTVPYHNFDHGWTVAHAMYAILKSDVKERFD-YNKASSRLALFVACLCHDLDHR 623
++ NY R YHN H V HA L KER + +A +A + HD+DH
Sbjct: 570 IEANYHRKNAYHNSTHAADVLHATAVFL---AKERVKAVLEPLDEVASLIAAIVHDVDHP 626
Query: 624 GYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTI-LQQDGHNIFSHISSEDYKEILGFI 681
GYTN ++ S LA +Y + LE HH + + + D NIFS++ E+++ + I
Sbjct: 627 GYTNSFLCNAGSELAILYNDIAVLESHHAALAFKLTARDDKSNIFSNLDVEEFRTVRQAI 686
Query: 682 RHCILATDLAAFFPNLDKI------RELYRSDEAQFS----WDDPSHRDLAMAISMTAAD 731
++AT++ F +L K R + ++ S + P +R L + + AD
Sbjct: 687 IDMVMATEMTRHFEHLSKFVNSINKRRSSSTPDSNTSTSTALNTPENRTLIKRMLIKCAD 746
Query: 732 LSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVGFLSQI 790
++ A+P + + I EE++ Q D+E+ G + +P+ DR P SQV F+
Sbjct: 747 IANPARPRYLCKEWAYRIAEEYFSQTDEEKRRGLPVVMPVFDR-ATCNVPRSQVWFIDYF 805
Query: 791 CIPCYDM--LYRILPNTKPMYAMATKNLNRWKARADKIL 827
YD + +P T T N + WK AD+++
Sbjct: 806 VSDLYDAWDAFAYVPET---IRHLTDNYDYWKKAADELV 841
>UniRef50_A2E0V4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein
- Trichomonas vaginalis G3
Length = 438
Score = 96.7 bits (230), Expect = 3e-18
Identities = 54/183 (29%), Positives = 95/183 (51%), Gaps = 8/183 (4%)
Query: 561 RFTLTVKKNYRTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVACLCHD 619
RF ++ Y+ VPYHN+ H V + Y I+ S ++ F L VA +C D
Sbjct: 198 RFLYAIRSMYKKVPYHNWRHAVDVTQFVTYQIMISGHEKVF----TKFEFNLVVAAICRD 253
Query: 620 LDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
+H G+TN Y + +PL +Y S +E HH +I + I+ + N+ + ++ ++ EI
Sbjct: 254 ANHDGFTNIYNIKAETPLGILYKNQSVMETHHCSIAIQIMSHEETNLLATLNQDECNEIW 313
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I ILATD+A F L + ++Y D++ F+ HR + + + + D+S ++P
Sbjct: 314 SLIIQYILATDMARHFEILKRFIDIY--DDSDFTTQRHDHRVMLLYMILKCGDISNVSRP 371
Query: 739 WEI 741
+E+
Sbjct: 372 FEL 374
>UniRef50_Q4RR95 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF15003, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 456
Score = 96.3 bits (229), Expect = 3e-18
Identities = 91/324 (28%), Positives = 143/324 (44%), Gaps = 38/324 (11%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF++ Q D+ L RF V+++Y + PYHN H
Sbjct: 135 DIFLFDRLTNGNSLVTLMCHLFNVYGLVHHFQLDMVKLHRFLGMVQEDYHSQNPYHNAVH 194
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AMY LK + K + L L A HD+DH G ++ +T LA++
Sbjct: 195 AADVTQAMYCYLK-EPKLAEQLSPLDVFLGLMAAA-AHDVDHPGVNQPFLIKTRHHLASL 252
Query: 641 Y-------TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATD---- 689
Y TS LE HH+ TV +L++ G + SH+ ++ ++I + ILATD
Sbjct: 253 YQVHQSVQNTSVLESHHWRSTVGMLRESG--LLSHLPADMSQDIEQQLGSLILATDISRQ 310
Query: 690 ---LAAFFPNLD-KIRELYRSDEAQFSWDDPSHRD-------LAMAISMTAADLSASAKP 738
L F +LD + +L F R + I++ AD+ +
Sbjct: 311 NEFLLTFGEHLDHQDLDLQLPSHRHFILQHAFRRSVPAVTACVCQQIALKCADVCNPCRV 370
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDML 798
W + + + + EEF+ QGD ER P+ D + +PA Q GF+S I P +D
Sbjct: 371 WALSRQWSERVCEEFFRQGDLERKFDLEISPLCDSRR--LRPAIQTGFISYIVEPLFDEW 428
Query: 799 YRIL---PNTKPMYAMATKNLNRW 819
+R P ++ M +N RW
Sbjct: 429 HRFTEPSPLSRTMMGHLHQNKARW 452
>UniRef50_Q01C40 Cluster: Cyclic GMP phosphodiesterase; n=1;
Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase -
Ostreococcus tauri
Length = 674
Score = 96.3 bits (229), Expect = 3e-18
Identities = 62/182 (34%), Positives = 90/182 (49%), Gaps = 7/182 (3%)
Query: 527 LDPFRFDEFE---KCKCIISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWT 583
L+ + FD FE CI+ MF +L D L RF V+ YR PYH F H +
Sbjct: 259 LNSWSFDVFEVSDSISCIMRMFHELNMFELVDPFKLRRFLSEVESMYRDNPYHCFKHAFD 318
Query: 584 VAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT- 642
VAH Y + + VK++ + ++ +L VA L HDLDH G TN Y+ T +A Y
Sbjct: 319 VAHTTYLYILA-VKDQVEMSQLEI-FSLLVAALVHDLDHPGVTNAYLIATRDSIAMTYND 376
Query: 643 TSTLEHHHFNITVTILQ-QDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIR 701
S LE+ H + T+ Q + NI S + Y + I C+L TD+A F + ++
Sbjct: 377 ESVLENLHLSRFFTLCQNNEDANILSAFDEDTYSVVRRTIIGCVLHTDMAHHFKLVSRMN 436
Query: 702 EL 703
E+
Sbjct: 437 EM 438
Score = 61.3 bits (142), Expect = 1e-07
Identities = 32/92 (34%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 712 SWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM 771
S+ R L + + + AD+S + KP E+ +K + EEF++QGD+ERA G PMM
Sbjct: 477 SFKTDEERQLMLNVLLHCADISNAVKPNELCVKWASRVLEEFFNQGDRERAKGMSVSPMM 536
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
DR + SQ+ F+ + P Y I P
Sbjct: 537 DR-ETTSVGLSQINFIEFVIAPLYVQFAAIFP 567
>UniRef50_UPI000150A9A4 Cluster: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein; n=1; Tetrahymena
thermophila SB210|Rep: 3''''5''''-cyclic nucleotide
phosphodiesterase family protein - Tetrahymena
thermophila SB210
Length = 929
Score = 95.9 bits (228), Expect = 4e-18
Identities = 82/295 (27%), Positives = 128/295 (43%), Gaps = 15/295 (5%)
Query: 536 EKCKCIISMFR--DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAMYAI 591
+K + SMF D + D +F ++ Y R P+HNF H V+HA Y
Sbjct: 615 DKLRYAWSMFHLAGFMDKLKIDKEVFLKFLQLLQHKYDKRQNPFHNFQHAIAVSHATYFF 674
Query: 592 LKSDVKERF-DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHH 649
+ + R+ DY + + L + L HD+ H G TN + T S LA + S LE+H
Sbjct: 675 INAKFLARYLDYLE---QFTLLFSSLGHDVSHTGRTNAFEVATLSKLAIKFNDESVLENH 731
Query: 650 HFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAF--FPNLDKIRELYRSD 707
H + I+Q+ HNIF +S+ED K I + IL+TD+ +I+ Y
Sbjct: 732 HSSTLFKIIQK--HNIFEQLSNEDVKNIRKYCISNILSTDMKKHQELTKQFEIKLTYLKQ 789
Query: 708 EAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIP 767
E + + L + ADL+ K +E+ + I +EF Q +E G
Sbjct: 790 EGTDLIKSEADKKLMCGFLVHVADLTGPTKCFELAKEWSMRICKEFTLQVQEEEHLGLPV 849
Query: 768 IPMMDRNKPEEQPASQVG-FLSQICIPCYDMLYRIL-PNTKPMYAMATKNLNRWK 820
P + + E + Q G F I +P Y +L P K M N+++W+
Sbjct: 850 TPYLVGLESMEIISKQEGNFAKIIVLPLYSVLSEFAGPEFKQMVKNCENNISQWE 904
>UniRef50_Q14432 Cluster: cGMP-inhibited 3',5'-cyclic
phosphodiesterase A; n=27; Euteleostomi|Rep:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A - Homo
sapiens (Human)
Length = 1141
Score = 95.9 bits (228), Expect = 4e-18
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 6.7
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>UniRef50_Q23RX8 Cluster: GAF domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: GAF domain containing
protein - Tetrahymena thermophila SB210
Length = 686
Score = 95.5 bits (227), Expect = 6e-18
Identities = 66/196 (33%), Positives = 104/196 (53%), Gaps = 18/196 (9%)
Query: 305 DKKRERNMS---DFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE 361
D KR N+S LL+V I + S D IL+ + + D AS+FLVDY++ E
Sbjct: 332 DLKRFFNLSLRYKELLNVTSEI-AKYTSFDHAFDMILKKIIQHLKCDTASIFLVDYQSQE 390
Query: 362 LVSTVFDLKFEPGLDLDMEKKEIRMPIN-RGIAGHVALSGETMNIPDAYSDYRFNRDVDE 420
L + + K IR P+N R IAG+ MN+ DAY D RFN+ VD
Sbjct: 391 LWTVA-----------NKTGKTIRFPLNDRSIAGYCIKHEIAMNVFDAYEDPRFNKQVDF 439
Query: 421 ATGYKTISILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGY+T +ILC+PIK + +V+G ++ +NK +D +F D+ EI +F L ++
Sbjct: 440 DTGYRTKTILCVPIKDQKNQVVGCLEAINKVND-FFNKQDQEMLEIMGSFCSSILQNSLK 498
Query: 480 YDRIMRKEQKYRVALE 495
+D+++ + Y+ ++
Sbjct: 499 FDKLLIQRDYYKKLIQ 514
>UniRef50_O95263 Cluster: High affinity cAMP-specific and
IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B;
n=83; Euteleostomi|Rep: High affinity cAMP-specific and
IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B -
Homo sapiens (Human)
Length = 885
Score = 95.5 bits (227), Expect = 6e-18
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 595 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 651
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 652 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 711
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 712 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 771
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 772 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 830
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 831 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 873
>UniRef50_Q8CFW8 Cluster: Phosphodiesterase 8B; n=13;
Euteleostomi|Rep: Phosphodiesterase 8B - Mus musculus
(Mouse)
Length = 730
Score = 94.7 bits (225), Expect = 1e-17
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 440 TTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 496
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 497 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALVFQLTVKDTKCNIFKNIDRN 556
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 557 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQIL 616
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 617 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 675
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 676 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 718
>UniRef50_UPI0000D56A7E Cluster: PREDICTED: similar to High-affinity
cAMP-specific and IBMX-insensitive 3,5-cyclic
phosphodiesterase 8A; n=1; Tribolium castaneum|Rep:
PREDICTED: similar to High-affinity cAMP-specific and
IBMX-insensitive 3,5-cyclic phosphodiesterase 8A -
Tribolium castaneum
Length = 862
Score = 94.3 bits (224), Expect = 1e-17
Identities = 80/314 (25%), Positives = 143/314 (45%), Gaps = 26/314 (8%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFD------MTQFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D FR +E K + + + +LF+ + D L + + ++ NY T YHN H
Sbjct: 524 DIFRLEELTKKRPLQYLGMNLFNNFDVAAVLNCDEKVLYNWLIIIEANYHTDNTYHNSTH 583
Query: 581 GWTVAHAMYAILKSD-VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAA 639
V A L+ + +K D ++ L +A HD+DH G +N ++S + +PLA
Sbjct: 584 AADVMQATAGFLEREKLKSIMDPLDEATSL---IAAAAHDVDHPGKSNAFLSNSDNPLAI 640
Query: 640 MYTTST-LEHHHFNITVTI-LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNL 697
+Y T LE HH + + L + N+F ++ E YK + ILAT++ F +L
Sbjct: 641 LYNDITILESHHAALMFKLTLGDERVNVFKNLDRETYKIARHNVIDMILATEMTKHFEHL 700
Query: 698 DKIRELY--RSDEAQFSWDD--------PSHRDLAMAISMTAADLSASAKPWEIQIKTVK 747
K ++ ++ + D P + L + + +D+S +P + ++ +
Sbjct: 701 AKFVNVFCTKTSNSDIELGDQDFPLLTQPENITLIKRMMIKCSDVSNPTRPLRLCVEWAR 760
Query: 748 VIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
I EE++ Q D+E+ G + +PM DRN P SQ+GF+ I ++ + +
Sbjct: 761 RIAEEYFQQTDEEKERGLPVVMPMFDRNTC-SIPKSQIGFVDYIINDMFE-AWNAFIDMP 818
Query: 807 PMYAMATKNLNRWK 820
+ +N RWK
Sbjct: 819 DLITYMRQNYIRWK 832
>UniRef50_Q13370 Cluster: cGMP-inhibited 3',5'-cyclic
phosphodiesterase B; n=26; Euteleostomi|Rep:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B - Homo
sapiens (Human)
Length = 1112
Score = 94.3 bits (224), Expect = 1e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 812 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFL 871
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
H+ ++K + ILATDL F L + + W + + R L +
Sbjct: 872 LHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQV 931
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ AK ++ +K + I EFY+QGD+E G +PI P MDR+ P + Q
Sbjct: 932 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLG-LPISPFMDRSSP-QLAKLQE 989
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 990 SFITHIVGP 998
>UniRef50_A0CZB5 Cluster: Chromosome undetermined scaffold_32, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_32, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 1270
Score = 93.1 bits (221), Expect = 3e-17
Identities = 79/304 (25%), Positives = 140/304 (46%), Gaps = 16/304 (5%)
Query: 505 EYEVQAMLLDKEPLNVDFADFYLDPFRFDEF------EKCKCIISMFRDLFDMTQFDITT 558
+Y+ Q ++ + D LD F F+ EK + + S+ ++Q+++
Sbjct: 927 KYQQQLEQVNINQFKILERDSQLDQFEFNILTLDSSQEKHRLVYSILEKNGFISQYNMNN 986
Query: 559 --LTRF--TLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVA 614
L +F L K N + +HN+DHG +V + + +L+ + ++F + R+A ++
Sbjct: 987 QCLAQFLSVLQQKYNKKNNSFHNYDHGISVMQSAHFMLQCEKAKQFIDD--FRRMATIIS 1044
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSED 673
LCHD+ H G TN +M + S LA Y +S LE HH T+ +L+ N S+++ E
Sbjct: 1045 GLCHDVSHTGRTNVFMINSQSKLATRYHDSSPLEQHHAATTIFMLKDSSLNFLSNLTKEQ 1104
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAISMTAADL 732
+++ + IL TD+ F L + D + F D + L I T AD
Sbjct: 1105 HQQFRRILIDNILYTDIKVHFTLLKDFESRIKDDVTKPFGTGDDDLKLLTGMIIHT-ADF 1163
Query: 733 SASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM-DRNKPEEQPASQVGFLSQIC 791
+ AK ++I + + +EF Q ++E G P + D +K S++GF I
Sbjct: 1164 NGGAKVFDISRIWSERVNKEFSAQYEEEGRLGIPQTPFLKDLHKIHIMAKSEMGFFKVIV 1223
Query: 792 IPCY 795
P +
Sbjct: 1224 RPLW 1227
>UniRef50_Q4SPD6 Cluster: Chromosome 16 SCAF14537, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 16 SCAF14537, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 560
Score = 92.7 bits (220), Expect = 4e-17
Identities = 79/327 (24%), Positives = 141/327 (43%), Gaps = 52/327 (15%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYH--------- 576
D + ++ E C+ M+ DL + +F++ TL R+ L +++NYR P+H
Sbjct: 203 DVWHWEHNEMLSCLEYMYHDLGLVKEFNMNPITLKRWLLAIQENYRNNPFHNFRHCFCVS 262
Query: 577 ----------NFDHGWTVAHAMYAILKSDVKERFDYNKASSRLA----LFVACLCHDLDH 622
N G + M + D ++ L L A +CHDLDH
Sbjct: 263 QMMYGMIHLCNLQVGSMLLTIMMLFITDPQVNPGDRDQEKLTLTDMGILMTAAVCHDLDH 322
Query: 623 RGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL--- 678
GY N Y + LA Y S LE+HH + IL NIF+++ E +K+I
Sbjct: 323 PGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILSLPECNIFANVDLEAFKQIRQVN 382
Query: 679 GFIRHCILA----------TDLAAFFPNL------------DKIRELYRSDEAQFSWDDP 716
G ++ +L ++L + F + +I + ++ F + +
Sbjct: 383 GAKQNHLLVLQTEGKLNVWSNLTSCFQGIITLILATDMARHGEILDSFKQKVDNFDFTNE 442
Query: 717 SHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKP 776
H + + D+S +P E+ V + EE++ Q D+E++ G P MDR+K
Sbjct: 443 EHVTCLKMVLIKCCDISNEVRPTEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK- 501
Query: 777 EEQPASQVGFLSQICIPCYDMLYRILP 803
+P +Q+GF+ + IP ++ + ++ P
Sbjct: 502 VTKPTAQIGFIKFVLIPMFETVMKLFP 528
>UniRef50_Q4SP32 Cluster: Chromosome 15 SCAF14542, whole genome
shotgun sequence; n=4; Tetraodontidae|Rep: Chromosome 15
SCAF14542, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 763
Score = 92.7 bits (220), Expect = 4e-17
Identities = 75/283 (26%), Positives = 130/283 (45%), Gaps = 35/283 (12%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T F LT++ +Y + V YHN H VA + + +L + +
Sbjct: 412 RDLMRTFKIPADTFVTFMLTLESHYHSNVAYHNSLHAADVAQSTHILLSTPALNAV-FTD 470
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ+D
Sbjct: 471 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC 529
Query: 664 NIFSHISSED----YKEILGFIR----------------------HCILATDLAAFFPNL 697
+IF +++ + + ++ +R H +LATD++ L
Sbjct: 530 DIFQNLTKKQRQTLRRMVIDMVRAARARAQGSRARFPSATLRWSPHQVLATDMSKHMSLL 589
Query: 698 DKIRELYRSDEAQFS----WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEF 753
++ + + + S D+ + R + + ADLS KP ++ + I +EF
Sbjct: 590 ADLKTMVETKKVTSSGVLLLDNYTDRMQVLRNMVHCADLSNPTKPLDLYRQWTDRIMDEF 649
Query: 754 YDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYD 796
+ QGD+ER G PM D++ + +QVGF+ I P ++
Sbjct: 650 FHQGDRERERGMEISPMCDKHTASVE-RTQVGFIDYIVHPLWE 691
>UniRef50_Q53E02 Cluster: TaR2; n=5; Cystobacterineae|Rep: TaR2 -
Myxococcus xanthus
Length = 529
Score = 92.7 bits (220), Expect = 4e-17
Identities = 51/166 (30%), Positives = 90/166 (54%), Gaps = 10/166 (6%)
Query: 328 VSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMP 387
V LD ++ +++ + ADR +L+L+D EL S L E +IR+
Sbjct: 42 VDLDAFLQTLMDRIAITLQADRGTLWLLDPARRELFSRAAHLP---------EVSQIRVK 92
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQM 446
+ +G+AG VA +G +N+PD + RF D+D TGY+T S+L +P++ +G + GV+Q+
Sbjct: 93 LGQGVAGTVAKAGHAINVPDPRGEQRFFADIDRMTGYRTTSLLAVPLRDGDGALYGVLQV 152
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRV 492
+N+R + F D+D ++ AL LY + R +++ +V
Sbjct: 153 LNRRGEDRFTDEDTQRLTAIASQVSTALQSTSLYQELQRAKEQPQV 198
>UniRef50_A4J938 Cluster: Metal dependent phosphohydrolase; n=1;
Desulfotomaculum reducens MI-1|Rep: Metal dependent
phosphohydrolase - Desulfotomaculum reducens MI-1
Length = 366
Score = 92.3 bits (219), Expect = 5e-17
Identities = 56/191 (29%), Positives = 106/191 (55%), Gaps = 7/191 (3%)
Query: 304 VDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELV 363
V KKR ++ + L ++ + I + L++++ L A + V+A+ +L+L D + +E +
Sbjct: 5 VKKKRWYHL-EALWEITR-ILHTSLDLEEVLDMALTEAMKAVHAEAGTLWLNDNQTNEFI 62
Query: 364 STVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATG 423
V L P D K +++ I G+AG V +G++ + D D R+++ D++TG
Sbjct: 63 QPV--LARGPKAD---GLKGLKLKIGEGMAGWVTANGQSQMVSDVLKDSRWSQRFDQSTG 117
Query: 424 YKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
+ T S+LC+P+ + IG +Q+VNK D + F +DD + E + G+A+ ++RLY +
Sbjct: 118 FITRSLLCVPLITQTSCIGCLQLVNKLDGQLFDEDDLSLCEALAGVIGMAVENSRLYTDL 177
Query: 484 MRKEQKYRVAL 494
+ + VAL
Sbjct: 178 KTMFKSFLVAL 188
>UniRef50_A5JZK3 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
putative; n=7; Plasmodium|Rep: 3',5'-cyclic-nucleotide
phosphodiesterase, putative - Plasmodium vivax
Length = 783
Score = 91.9 bits (218), Expect = 7e-17
Identities = 70/266 (26%), Positives = 121/266 (45%), Gaps = 9/266 (3%)
Query: 558 TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLC 617
TL +K+ Y VPYHN H VA ++ + + + + + A +A L
Sbjct: 483 TLRSLLCEMKEGYNNVPYHNCIHAAMVAEQCNILVNN--LDTANILRDNEMAAFLLAALG 540
Query: 618 HDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKE 676
HD+ H G TN ++ +++ L+ +Y S LE++H + IL ++ +NIF + S++
Sbjct: 541 HDIGHFGRTNLFLKNSSNFLSVIYNDKSILENYHCSYLFHILFKEQNNIFKNESAKTVLN 600
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ I ILATD++ KI +R + + L + + + AADLS +
Sbjct: 601 LRQEIIQVILATDMSKHI----KILAQFRIKSIKIRSYIEKNIILCLKMIIKAADLSHNC 656
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYD 796
W VK + EFY +GD++ G P+ DRN + Q FL ++ P
Sbjct: 657 VDWSEHYLWVKRLVNEFYYEGDEQLEKGYQINPLFDRNSHDNFIKIQRTFLKELVFPLII 716
Query: 797 MLYRILPNTKPMYAM--ATKNLNRWK 820
L + + + M +N ++WK
Sbjct: 717 SLKTLDRTSIAQFMMDKVKRNYSKWK 742
>UniRef50_O43851 Cluster: PDE4C-delta109; n=18; Bilateria|Rep:
PDE4C-delta109 - Homo sapiens (Human)
Length = 427
Score = 91.9 bits (218), Expect = 7e-17
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 6/193 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFS 667
LA A HD+DH G +N+++ T S LA MY S LE+HH + +LQ + +IF
Sbjct: 134 LAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQ 193
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FSWDDPSHRDLAM 723
++S++ + + +LATD++ L ++ + + + D+ S R +
Sbjct: 194 NLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVL 253
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQ 783
+ ADLS KP + + I EF+ QGD+ER +G PM D++ + SQ
Sbjct: 254 QNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVE-KSQ 312
Query: 784 VGFLSQICIPCYD 796
VGF+ I P ++
Sbjct: 313 VGFIDYIAHPLWE 325
>UniRef50_Q9N2V9 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-6; n=3; Caenorhabditis|Rep: Probable 3',5'-cyclic
phosphodiesterase pde-6 - Caenorhabditis elegans
Length = 760
Score = 91.9 bits (218), Expect = 7e-17
Identities = 72/235 (30%), Positives = 116/235 (49%), Gaps = 12/235 (5%)
Query: 559 LTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLC 617
L R+ L+++ +Y YHN H V A L S N++ + AL A +
Sbjct: 484 LHRWILSIEAHYHAGNTYHNATHAADVLQATSFFLDSP-SVAVHVNESHAVAALLAAAV- 541
Query: 618 HDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTI-LQQDGH-NIFSHISSEDY 674
HDLDH G N Y+ T LA +Y S LE+HH + + LQ + + NIFS +S E++
Sbjct: 542 HDLDHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANVNIFSSLSREEF 601
Query: 675 KEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSA 734
++ + +LATD++ F L K +++ +D + D S M + AD+S
Sbjct: 602 IQMRHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTNSLTICDMLVK--CADISN 659
Query: 735 SAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM--MDRNKPEEQPASQVGFL 787
A+ W + + I EE+++Q +E+ G +P+ M DRN P +Q GF+
Sbjct: 660 PAREWGLCQRWAHRIVEEYFEQTREEKEKG-LPVTMEVFDRNTC-NVPITQCGFI 712
>UniRef50_Q4RH59 Cluster: Chromosome undetermined SCAF15069, whole
genome shotgun sequence; n=3; Euteleostomi|Rep:
Chromosome undetermined SCAF15069, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 695
Score = 91.1 bits (216), Expect = 1e-16
Identities = 78/279 (27%), Positives = 121/279 (43%), Gaps = 38/279 (13%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y +LK+ + +
Sbjct: 254 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKTGMVH---WL 310
Query: 604 KASSRLALFVACLCHDLDHRGYTN---------KYMS-------------ETASPLAAMY 641
A+ A HD +H G TN KY S E S A +Y
Sbjct: 311 TELEIFAMIFAAAVHDYEHTGTTNNFHIQTSSAKYTSCICPVQLQQDPKNEIKSDTAILY 370
Query: 642 TT-STLEHHHFNITVTILQQDGH-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
S LE HH + +LQ D NI ++S +D++E+ + +LATD++ F +
Sbjct: 371 NDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWRELRALVVEMVLATDMSCHFQQVKA 430
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + E D P A+++ + AD+S AK W++ + EEF+ QGDK
Sbjct: 431 MKNFLQQPEGI---DKPK----ALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDK 483
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDML 798
E G P+ DR K SQ+GF+ I +P + +L
Sbjct: 484 EADLGLPFSPLCDR-KSTMVAQSQIGFIDFIVVPTFTVL 521
>UniRef50_A2DBZ3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1126
Score = 91.1 bits (216), Expect = 1e-16
Identities = 69/296 (23%), Positives = 135/296 (45%), Gaps = 23/296 (7%)
Query: 536 EKCKCIISMF--RDLFDMTQFDITTLTRFTLTVKKNYR-TVPYHNFDHGWTVAHAMYAIL 592
EK +C + F +L + D+ LT F ++NY + +HNF+H ++ L
Sbjct: 848 EKTECAMKFFINAELLNAIGGDLEKLTNFVTFTRENYNENLKFHNFEHALDFTQFVFVCL 907
Query: 593 KSDVKERF-DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHH 650
+ +F + + AL A L HD++H G ++++T+S L +Y STLE HH
Sbjct: 908 ---TRNKFGNCMNVDQKAALLCASLLHDVNHDGTNTLFLNQTSSYLVDLYGKESTLERHH 964
Query: 651 FNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ 710
+ + I+++ G I+ +D + F + ILATD++ F N+ K+ L +
Sbjct: 965 VSEALRIVEKSG------ITLKDKR----FFVNAILATDMSKFEENVQKVTVL----RGK 1010
Query: 711 FSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIP 769
F+ D + L + M +++ + +P+ + K I E+ + E G +
Sbjct: 1011 FNKTDKTQVPLVATLLMMCGNVANTTRPFYFASECGKRILSEYQEISKLEEQNGIQNHQK 1070
Query: 770 MMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
+ ++ + P ++ F+++I +P ++L + P+ K N +W K
Sbjct: 1071 ICGKSITDPLPEIELAFINEIALPLLEILEDVSPDFKDFKVQCQDNKEQWTKETKK 1126
>UniRef50_A0CU34 Cluster: Chromosome undetermined scaffold_28, whole
genome shotgun sequence; n=4; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_28,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 903
Score = 91.1 bits (216), Expect = 1e-16
Identities = 68/238 (28%), Positives = 105/238 (44%), Gaps = 5/238 (2%)
Query: 564 LTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHR 623
L K N P+HNF HG V H + + K F +N R A+ +A LCHD+ H
Sbjct: 636 LKYKYNKTANPFHNFTHGVNVMHGCF-LFTHHPKFGFCFND-QQRFAMTLAGLCHDVGHP 693
Query: 624 GYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIR 682
G N + T + LA +Y S LE+HH +T +L + + + D I +I
Sbjct: 694 GTNNLFQVNTQTKLALLYNDKSVLENHHIAVTYKLLALEQCDFLESVPRADKLMIRKYIV 753
Query: 683 HCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMT-AADLSASAKPWEI 741
+ +LATD F L+ I + + + L ++ +T AAD +AK +++
Sbjct: 754 NNVLATDNQFHFKILNDIEIKFAQSQGDPKIFESDDNKLLLSGFLTHAADFFGAAKSYQV 813
Query: 742 QIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA-SQVGFLSQICIPCYDML 798
+ + EF Q E G P + E Q A +++GFL I P Y+ L
Sbjct: 814 ARTWSERLRREFQAQSQLEDIVGIAQTPYLRNLDDEVQYAKNEIGFLKVIVKPIYESL 871
>UniRef50_Q4SI77 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 750
Score = 89.8 bits (213), Expect = 3e-16
Identities = 56/188 (29%), Positives = 90/188 (47%), Gaps = 4/188 (2%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH ++ L + N
Sbjct: 445 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAAWSLYLSRPEFNFL 504
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS-DEAQFSWDDPSHRDLAMAI 725
++ ++K + ILATDL F L + + W + + R L +
Sbjct: 505 VNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGIDWTNENDRLLVCQV 564
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVG 785
+ AD++ AK ++ ++ + I EFY+QGD+E G P MDR+ P + Q
Sbjct: 565 CIKLADINGPAKIRDLHLQWTEGIVNEFYEQGDEEAKLGLPVSPFMDRSSP-QLAKLQES 623
Query: 786 FLSQICIP 793
F++ I P
Sbjct: 624 FITHIVGP 631
>UniRef50_Q01CI7 Cluster: Cyclic GMP phosphodiesterase; n=1;
Ostreococcus tauri|Rep: Cyclic GMP phosphodiesterase -
Ostreococcus tauri
Length = 526
Score = 89.4 bits (212), Expect = 4e-16
Identities = 69/305 (22%), Positives = 142/305 (46%), Gaps = 22/305 (7%)
Query: 536 EKCKCIISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSD 595
EK + + DLF +++ RF ++ +YR YHN H V A +++
Sbjct: 224 EKLSMELFEYFDLFKTLPLKRSSVKRFLADIEVSYRDNDYHNGVHAADVTQAAAYFIETS 283
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
++++ + AL ++ + HD+ H G N Y+ + +A + S E+ H
Sbjct: 284 LRDQIE---PIHIFALLLSAVVHDVGHPGLNNAYLVARQTDVAERWNNVSVNENGHLYTA 340
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWD 714
T+L+Q +++ + +D +L ++ +L TD+ + D ++++ + E +F +
Sbjct: 341 NTLLKQ--YDVLKDFADDDRVLVLKLLQKMVLCTDMEV---HADLVKKVIEAVEREFDKE 395
Query: 715 DPSHRD--------LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRI 766
+ + +A ++ AD+S A+P+++ + I EEF+ QGD +R ++
Sbjct: 396 AGLLKPVKEWGEVWIPLAFALHCADISNPARPYDLALYWANAIVEEFFKQGDLQRGF-QM 454
Query: 767 PIP-MMDRN--KPEEQPASQVGFLSQICIPCYDMLYRILPN-TKPMYAMATKNLNRWKAR 822
+P MDR P +SQ+GF+ I P ++L +P + + N+ R++
Sbjct: 455 SVPGFMDRRLASPAGTQSSQLGFIKVIVKPSLELLDSYMPQAAAELLSHIETNIERYEDD 514
Query: 823 ADKIL 827
+K L
Sbjct: 515 VNKAL 519
>UniRef50_A5K353 Cluster: 3',5'-cyclic-nucleotide phosphodiesterase,
putative; n=5; Plasmodium|Rep: 3',5'-cyclic-nucleotide
phosphodiesterase, putative - Plasmodium vivax
Length = 803
Score = 89.0 bits (211), Expect = 5e-16
Identities = 66/210 (31%), Positives = 101/210 (48%), Gaps = 22/210 (10%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR---LALFVAC 615
L F L + Y PYHN +HG TV H L + D++K+ + + +A
Sbjct: 419 LQLFLLLINNMYFPNPYHNANHGATVCH-----LSKCLAHITDFDKSLNNTYMICYLIAS 473
Query: 616 LCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSED- 673
+ HD+ H G TN Y+SET L+ Y S LE++H +IT +ILQ GH+ I+SED
Sbjct: 474 IAHDVGHPGKTNAYLSETNHILSIRYNDMSILENYHCSITFSILQLIGHDFL--INSEDT 531
Query: 674 -------YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAIS 726
Y + FI I++TD+ F +D ++ RS+ F D +L I+
Sbjct: 532 KLVEKNSYANLRKFIIELIISTDMKLHFEYVDIFKKRKRSE--NFDISDRDAINLG-TIN 588
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQ 756
+ AD+ + W K ++ EEF+ Q
Sbjct: 589 IKVADIGHTCLKWRDHAKWTMLVSEEFFSQ 618
>UniRef50_Q22SL3 Cluster: GAF domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: GAF domain containing
protein - Tetrahymena thermophila SB210
Length = 624
Score = 88.6 bits (210), Expect = 7e-16
Identities = 56/178 (31%), Positives = 94/178 (52%), Gaps = 13/178 (7%)
Query: 332 QLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRG 391
+ ++ I+E + +DRAS+F+ + + +L + K G K I++P ++G
Sbjct: 336 EALENIVEETCNCLESDRASVFIFEQESEQLWT-----KHAKG-----SNKTIKVPFDQG 385
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEG-KVIGVVQMVNK 449
I G V SG+ +NI +AY+D RFN+++D+ YKT ++L PI +G V+GV+Q VNK
Sbjct: 386 IVGAVFTSGQHLNILNAYNDERFNKEIDKMMNYKTNTVLAFPIFDRDGINVLGVIQSVNK 445
Query: 450 RDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
YF DDE + S + L ++ +D+ M + R L+ +TC E
Sbjct: 446 LKG-YFTKDDEGLMLVISQLASIVLRNSEQFDQTMLFQNNLRTLLQTGIQLSTCLNLE 502
Score = 45.2 bits (102), Expect = 0.008
Identities = 47/198 (23%), Positives = 87/198 (43%), Gaps = 17/198 (8%)
Query: 247 NKQGNYILYQPIITKSGKT--SYVLEMWRTKDRFKVIDEEISGHIVVWGSVALHYCKLYV 304
N + N +L PI + G + + + K F DE + I S+ L + +
Sbjct: 417 NYKTNTVLAFPIFDRDGINVLGVIQSVNKLKGYFTKDDEGLMLVISQLASIVLRNSEQFD 476
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
+N LL + ++L++ I + + Q L N+++ + +VD + +L S
Sbjct: 477 QTMLFQNNLRTLLQTGIQL-STCLNLEEFIPKAEKKLQDLFNSNKGKILIVDEQQKKLFS 535
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
D K+++ + GIAG ET+NI +AY+ + FN +VD T
Sbjct: 536 IHSD-----------SKQKVYHELGVGIAGKTYELAETLNISNAYNHHLFNSEVDLDT-- 582
Query: 425 KTISILCMPIKVEGKVIG 442
++ I+ MP+K + +G
Sbjct: 583 -SMPIISMPVKRDKPFVG 599
>UniRef50_A0CZ03 Cluster: Chromosome undetermined scaffold_31, whole
genome shotgun sequence; n=4; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_31,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 692
Score = 88.6 bits (210), Expect = 7e-16
Identities = 75/313 (23%), Positives = 130/313 (41%), Gaps = 12/313 (3%)
Query: 516 EPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFD-MTQFDI-----TTLTRFTLTVKKN 569
E L+ D Y+DPF D+ + ++ + LF+ +D+ + + V +
Sbjct: 368 ELLDKQHDDLYIDPFECDKLSGGEGLVYLMLFLFENYNLYDVFLIKPKVVRSYFEEVMRG 427
Query: 570 YRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKY 629
Y+ PYHN H VA +L + +A HD H G TN +
Sbjct: 428 YQDNPYHNRVHAQDVAQTCNFLLNRCKFIEIGQLDEQDIACVLIAGAIHDYGHPGLTNAF 487
Query: 630 MSETASPLAAMYTT-STLEHHHFNITVTILQQDGH-NIFSHISSEDYKEILGFIRHCILA 687
+ + + LA Y S LE H + I + NIF ++ + Y+ I I +L+
Sbjct: 488 LINSKNELALTYNDQSVLEMFHPSQCFKIAWTNQKANIFESLTFQKYRRIRESIISMVLS 547
Query: 688 TDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVK 747
TD+A L + + + D + M + + ++D+S K +EI + +
Sbjct: 548 TDMAHHASELAITNSRVAAPDFEPYGKD---KQRLMDLVVHSSDVSNPTKSFEIYKQWTE 604
Query: 748 VIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKP 807
+ EF+ QGDKER G +PI + +Q+GF+ + P + + LP +P
Sbjct: 605 RVLTEFWLQGDKERELG-LPISYLCNRYTTNMAEAQLGFIDYVVKPTFSCVQGFLPAFEP 663
Query: 808 MYAMATKNLNRWK 820
KN +W+
Sbjct: 664 YLENLDKNKAKWQ 676
>UniRef50_A0C536 Cluster: Chromosome undetermined scaffold_15, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_15,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 512
Score = 88.6 bits (210), Expect = 7e-16
Identities = 58/176 (32%), Positives = 99/176 (56%), Gaps = 14/176 (7%)
Query: 319 VVKAIFE--EMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLD 376
++KA ++ + L+ I I++ Q+L+N +RA+ ++VD E+ S V G++
Sbjct: 200 IIKASYQMNQQGQLNDAISCIVDQTQQLMNCERATCYIVDETKGEIWSRVAQ-----GIN 254
Query: 377 LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKV 436
IRMPI++G+AG VA E++NIP+AY+D RFNR+ D +KT SIL PI
Sbjct: 255 -----SIIRMPIDQGVAGFVAFRKESVNIPNAYADDRFNRESDLINHFKTQSILAAPIIG 309
Query: 437 E-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYR 491
+ + +GV+Q +NK + F ++D A + F L+H+ +++ + K R
Sbjct: 310 DNNQCLGVLQCLNK-NQGVFTNEDSAYLKYICNFSKAVLNHSLNQNQVESTQNKLR 364
>UniRef50_A0BZK9 Cluster: Chromosome undetermined scaffold_139,
whole genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_139,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 987
Score = 88.6 bits (210), Expect = 7e-16
Identities = 81/329 (24%), Positives = 139/329 (42%), Gaps = 22/329 (6%)
Query: 502 TCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDITT--L 559
T +E+++ L+ + +D DF + + +K + + + + + F I + L
Sbjct: 660 TIQEWDLNEFCLENQDDLIDSFDFNIMDLT-SQIQKHRVVWVILKKNGHLDDFQIPSENL 718
Query: 560 TRFTLTVKKNYRTV--PYHNFDHGWTV---AHAMYAILKSDVKERFDYNKASSRLALFVA 614
F ++ NY PYHN+DHG TV AH + L K + N +R L ++
Sbjct: 719 QSFIKEMEYNYNVNNNPYHNYDHGITVMQTAHYFCSELAQTSKSKIIDN--FNRFILMIS 776
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSED 673
HD+ H G TN + + S LA Y S LE HH +T+ +L+ NI +++ ++
Sbjct: 777 SFGHDVGHTGKTNVFEINSLSDLAIRYHDKSVLEQHHAALTIQVLKNPQSNILVNLNQQE 836
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLS 733
++ + IL+TD++ F L + + F + + M +D
Sbjct: 837 FRNFRKGLIANILSTDMSEHFTLLKD----FENRPTDF-----NDCKILSGYIMHTSDFG 887
Query: 734 ASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP-MMDRNKPEEQPASQVGFLSQICI 792
+ K + IK + +EF Q E G P M D + P S++GFL I
Sbjct: 888 GAGKKTNLSIKWSSRVNQEFSIQYKLEGELGYPQQPYMKDLHIPHVMAKSEIGFLKVIVR 947
Query: 793 PCYDMLYRILPN-TKPMYAMATKNLNRWK 820
PCY + L + K A + W+
Sbjct: 948 PCYALFSEFLEDRLKHCMANIDDTIQHWE 976
>UniRef50_Q8F1G6 Cluster: Sigma factor sigB regulation protein rsbU;
n=4; Leptospira|Rep: Sigma factor sigB regulation
protein rsbU - Leptospira interrogans
Length = 556
Score = 88.2 bits (209), Expect = 9e-16
Identities = 49/150 (32%), Positives = 88/150 (58%), Gaps = 5/150 (3%)
Query: 337 ILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHV 396
I+ +++ L+ A+ +SLFL++ L V E G ++ +K R+ + GIAG V
Sbjct: 2 IMLYSKDLLEAEASSLFLINETREFLYCEV--ALGEKG---EIIQKYGRLNLGEGIAGWV 56
Query: 397 ALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFG 456
A +T+ + DAYSD RFN D+ TGY+T S++C+P+ VE KVIG ++++NK ++ F
Sbjct: 57 AKEKKTIILEDAYSDSRFNPSWDQKTGYRTRSLICVPLFVENKVIGTLEILNKTQNRSFD 116
Query: 457 DDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
D S +A+ +A++++ + ++
Sbjct: 117 SSDLNYLTSLSEVAAIAIQNAKIHENLKKR 146
>UniRef50_A0H2E0 Cluster: GAF; n=2; Chloroflexus|Rep: GAF -
Chloroflexus aggregans DSM 9485
Length = 592
Score = 88.2 bits (209), Expect = 9e-16
Identities = 57/193 (29%), Positives = 103/193 (53%), Gaps = 14/193 (7%)
Query: 301 KLYVDKKRERNMSDF-LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN 359
K+ + ++ ER++ + LL + + + L L+ I A ++V A+R S+F++D
Sbjct: 199 KIAMLRRAERDLRELHLLYEIGQLLAVNLDLTSLLNDIKLRAPKVVGAERCSIFILDEET 258
Query: 360 SELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVD 419
+ELV + PG E++ RMP +RGIAG V G + D D R+ +
Sbjct: 259 NELVLEI------PG-----EQRRYRMPADRGIAGWVVTHGVGQIVNDVEHDPRWYDAIS 307
Query: 420 EATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
+ T SI+C+P++V+ ++IG +Q++NK D + F + D + +A+ +ARL
Sbjct: 308 READFVTRSIVCVPMRVKDRIIGAMQLLNKIDGQPFNEQDLQLLTTLAAQAAIAIENARL 367
Query: 480 YDRIMRKEQKYRV 492
Y R+ KE++ R+
Sbjct: 368 YQRL--KEERDRL 378
>UniRef50_A5UVY8 Cluster: GAF sensor signal transduction histidine
kinase; n=3; Chloroflexi (class)|Rep: GAF sensor signal
transduction histidine kinase - Roseiflexus sp. RS-1
Length = 545
Score = 87.8 bits (208), Expect = 1e-15
Identities = 72/262 (27%), Positives = 125/262 (47%), Gaps = 25/262 (9%)
Query: 306 KKRERNMSDF-LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
++ E+++ + LL V + L L+ I + + A+R S+ L+D + ELV
Sbjct: 156 RRAEQDLRELHLLYQVGQALASNLDLSSLLNDIRNQVPQAMGAERCSIMLLDEQTRELVL 215
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
+ D + G E++E R+P++RGIAG VA +G + D D R+ V +
Sbjct: 216 ELPD-PYHTG-----EQREFRIPLDRGIAGWVATNGIGQIVNDVEQDPRWFDGVARDVDF 269
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL----- 479
T ILC P+++ +V+GV+Q++NKRD F + D +T +A+ +ARL
Sbjct: 270 VTRQILCAPMRIGDRVVGVMQVLNKRDGTPFDEQDLRLLTTLATQAAIAVENARLVRRLK 329
Query: 480 --YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEK 537
+DR++ KE + R A+ + + AM N++F L E+
Sbjct: 330 EEHDRLLAKEAEVRAAIARDLHDGPTQSVAAIAM-------NIEFIKKLLRAMP----ER 378
Query: 538 CKCIISMFRDLFDMTQFDITTL 559
+ +++ DL T +DI TL
Sbjct: 379 VESELNVLADLVQKTAYDIRTL 400
>UniRef50_A4RUJ3 Cluster: Predicted protein; n=1; Ostreococcus
lucimarinus CCE9901|Rep: Predicted protein -
Ostreococcus lucimarinus CCE9901
Length = 614
Score = 87.8 bits (208), Expect = 1e-15
Identities = 60/266 (22%), Positives = 126/266 (47%), Gaps = 15/266 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKAS 606
+LF D +++ F +++ YR YHN H V A ++++ ++ + +
Sbjct: 326 NLFHALPLDRNSVSNFIADIERKYRDNDYHNRVHATDVTQAAAYLIETSLESQIE---PI 382
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNI 665
A+ VA + HD+ H G N ++ S A + S E+ H ++L++ H +
Sbjct: 383 HTFAMLVAAMSHDVGHPGVNNTFLVNCKSAEAERWNDVSVNENGHLFTAFSLLKK--HAV 440
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDK--IRELYRSDEAQFSWDDPSHRD--- 720
+ + + ++ +++ I+ TD+ F L + ++E+ + + + P +
Sbjct: 441 LAKFTDSEQSDLKKWLQKMIMYTDME-FHGELTQRMLKEIEDEQDEETNSIKPIKQWQNI 499
Query: 721 -LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRN--KPE 777
+ +A ++ AD+S A+P+E+ + + + EFY QGD++R G P MDR+ P
Sbjct: 500 WVPLAFALHCADISNPARPYELALAWAQAVTAEFYKQGDRQRKLGMRVEPFMDRSLAGPA 559
Query: 778 EQPASQVGFLSQICIPCYDMLYRILP 803
++Q+GF+ + P +L +P
Sbjct: 560 STQSNQLGFIKLVVKPSLCVLEAFMP 585
>UniRef50_UPI0000519BD4 Cluster: PREDICTED: similar to
phosphodiesterase 8A; n=1; Apis mellifera|Rep:
PREDICTED: similar to phosphodiesterase 8A - Apis
mellifera
Length = 820
Score = 87.4 bits (207), Expect = 2e-15
Identities = 68/278 (24%), Positives = 129/278 (46%), Gaps = 21/278 (7%)
Query: 564 LTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDH 622
+ ++ NY T YHN H V A ++++ ++ + +A +A HD+DH
Sbjct: 523 IVIEANYDITNRYHNSTHAADVLQAAAMFMQTERLKQV--LEPLDEVATLIAAAAHDIDH 580
Query: 623 RGYTNKYMSETASPLAAMYTTST-LEHHHFNITVTI-LQQDGHNIFSHISSEDYKEILGF 680
G +++++ + + LA +Y T LE HH +T + L D NIF ++ + YK++
Sbjct: 581 PGRSSQFLCNSDNKLAILYNDLTVLESHHAALTFKLTLSDDNVNIFKNLERDTYKQVRQS 640
Query: 681 IRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI-----------SMTA 729
+ ILAT++ F +L K + + + + DL+ AI +
Sbjct: 641 VIDMILATEMTKHFEHLAKFMNAFSTRIPEMYIEGSQDLDLSAAILPENVILVKRMIIKC 700
Query: 730 ADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI--PMMDRNKPEEQPASQVGFL 787
AD+S +P + ++ + I EE++ Q D+E+ +P+ PM DR P +Q+GF+
Sbjct: 701 ADVSNPTRPLKYCVEWARRIAEEYFSQTDEEKQL-HLPVMMPMFDRITC-SIPRAQIGFI 758
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
I + + + N + +N ++WK +K
Sbjct: 759 DFIINDMVE-AWDVFINMPEIVGFMRQNYDKWKEYNEK 795
>UniRef50_Q4RSB8 Cluster: Chromosome 13 SCAF15000, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 13 SCAF15000, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 737
Score = 87.4 bits (207), Expect = 2e-15
Identities = 57/189 (30%), Positives = 91/189 (48%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T++P A +Y S LE+HH + + +N
Sbjct: 425 MALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSHPEYNFL 484
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
++ ++K + ILATDL F L + D + W + + R L +
Sbjct: 485 VNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKVGDDPSTGIDWSNENDRLLVCQM 544
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ K ++ ++ + I EFY QGD+E G +PI P MDR P + Q
Sbjct: 545 CIKLADVNGPLKCKDLHLQWTEGIVNEFYQQGDEESTLG-LPISPFMDRAAP-QLAKLQE 602
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 603 SFITHIVGP 611
>UniRef50_A5UQK5 Cluster: Sensor protein; n=2; Roseiflexus|Rep:
Sensor protein - Roseiflexus sp. RS-1
Length = 1017
Score = 87.4 bits (207), Expect = 2e-15
Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 9/196 (4%)
Query: 289 IVVWGSVALHYCKLYVDKKRERNMSDFL-LDVVKAIFEEMVSLDQLIKRILEFAQRLVNA 347
I +VAL LY ++ ER L L+ + I + Q+ IL L++A
Sbjct: 299 IAAHAAVALDRAWLY--ERAERQAQQLLVLNRIGRIITSSIDPQQVPDIILRQVTELLDA 356
Query: 348 DRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPD 407
+ +SL L D E+V + G + R+P GIAG+VA +G+++ + D
Sbjct: 357 EESSLLLTDDHTGEMV-----FAYTTG-QVGKRILGQRLPRGVGIAGYVAATGQSVIVND 410
Query: 408 AYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFS 467
SD RF R +D +TGY T ++L +P++ G V GV++++N+RD + F +D+ E +
Sbjct: 411 VQSDERFYRSMDLSTGYTTRTLLAVPLRGVGGVEGVIEVLNRRDLRPFTVEDQRLLEALA 470
Query: 468 TFFGLALHHARLYDRI 483
+ +AL +AR + +I
Sbjct: 471 DYAVIALENARQFQKI 486
>UniRef50_Q22CV4 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Tetrahymena thermophila SB210|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Tetrahymena thermophila SB210
Length = 1258
Score = 87.4 bits (207), Expect = 2e-15
Identities = 82/312 (26%), Positives = 135/312 (43%), Gaps = 16/312 (5%)
Query: 519 NVDFADFYLDPFRFDEFEKCKCIISMFR--DLFDMTQFDITTLTRFTLTVKKNY--RTVP 574
N+D DF + R E EK ++ + F+ F ++K Y +
Sbjct: 834 NIDDWDFNVFELRSVE-EKYTTAWNILQRAQYFESCSIPEDVFANFVKELQKQYDIKNND 892
Query: 575 YHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETA 634
+HNFDHG +V + Y + K + K + ++ LCHD+ H G TN +
Sbjct: 893 FHNFDHGVSVMQSCYMLSKC--QRATQVLKPIDIFTVILSGLCHDVGHTGRTNNFEISVQ 950
Query: 635 SPLAAMY-TTSTLEHHHFNITVTILQQD-GHNIFSHISSEDYKEILGFIRHCILATDLAA 692
S LA Y S LE HH T I++Q +NI ++ Y ++ + IL TD+
Sbjct: 951 SKLAIRYHDKSVLEQHHLATTFKIMKQSLDYNILQNLEPITYNQVRRSMISNILYTDIKQ 1010
Query: 693 FFP-NLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F LD + DE + + DL + + AD + +AKP+ + + + +
Sbjct: 1011 HFKLILDFETQWKNYDEQLKTTNSEGEIDLLTGMIIHTADFTGAAKPFPLSRQWSEKVNR 1070
Query: 752 EFYDQGDKERAAGRIPIPMM-DRNKPEEQPASQVGFLSQICIPCYDML---YRILPNTKP 807
EF++Q +E G M D + ++ GFLS I +P + L Y+ NT+
Sbjct: 1071 EFHNQYIEEGKRGVEQTSFMKDLDILHVMAKAEKGFLSVIVLPLWKSLNDFYKGELNTQI 1130
Query: 808 MYAMATKNLNRW 819
Y T ++N+W
Sbjct: 1131 EY--LTDSINQW 1140
>UniRef50_Q8IKD3 Cluster: Cyclic nucleotide phosphodiesterase,
putative; n=1; Plasmodium falciparum 3D7|Rep: Cyclic
nucleotide phosphodiesterase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 813
Score = 87.0 bits (206), Expect = 2e-15
Identities = 58/205 (28%), Positives = 95/205 (46%), Gaps = 12/205 (5%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCH 618
L F L + Y PYHN +HG TV H + + + + Y + + +A + H
Sbjct: 440 LQLFLLLINSMYFPNPYHNANHGATVCHLSKCL--AHITDYDSYLNNTYMICYLIASIAH 497
Query: 619 DLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSH------ISS 671
D+ H G TN Y+SET L+ Y S LE++H +IT +ILQ G + + +
Sbjct: 498 DVGHPGKTNSYLSETNHILSIRYNDMSILENYHCSITFSILQLIGFDFLINNEDTKLVEK 557
Query: 672 EDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAAD 731
+Y + FI I++TD+ F +D ++ R F D +L I++ AD
Sbjct: 558 NNYTNMRKFIIELIISTDMKLHFEYVDIFKK--RKKSQNFDISDTDAINLG-TINIKLAD 614
Query: 732 LSASAKPWEIQIKTVKVIFEEFYDQ 756
+ + W+ K ++ EEF+ Q
Sbjct: 615 IGHTCLKWKDHAKWTMLVSEEFFSQ 639
>UniRef50_Q53I59 Cluster: Cyclic nucleotide specific
phosphodiesterase; n=3; Trypanosoma cruzi|Rep: Cyclic
nucleotide specific phosphodiesterase - Trypanosoma
cruzi
Length = 924
Score = 86.6 bits (205), Expect = 3e-15
Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 7/240 (2%)
Query: 566 VKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGY 625
V+ NYR PYHN H V ++++ S K ++ A A L HD+ H G
Sbjct: 358 VENNYRPNPYHNAIHAADVLQGTFSLV-SAAKPLMEHLTPLECKAAAFAALTHDVCHPGR 416
Query: 626 TNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHC 684
TN +++ P++ ++ TLE H +L + S + + + E + H
Sbjct: 417 TNAFLAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHL 476
Query: 685 ILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIK 744
I TD++ + K + F R A+++ + AAD+ AS++ I K
Sbjct: 477 IGHTDMSLHSETIAKHGA--KLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARK 534
Query: 745 TVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+ VI +EF DQ + ER G P D P SQ+ FL IP +D+L+++ P+
Sbjct: 535 WL-VILQEFADQAEDERRRGLPVTPGFDT--PSSVEKSQIPFLDFFVIPTFDLLHQLFPS 591
>UniRef50_Q01S08 Cluster: Transcriptional regulator, NifA subfamily,
Fis Family; n=1; Solibacter usitatus Ellin6076|Rep:
Transcriptional regulator, NifA subfamily, Fis Family -
Solibacter usitatus (strain Ellin6076)
Length = 509
Score = 85.0 bits (201), Expect = 8e-15
Identities = 58/177 (32%), Positives = 99/177 (55%), Gaps = 15/177 (8%)
Query: 317 LDVVKAIFEEMVS---LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEP 373
L + AI ++M S L +L+ I A L++ DRAS+FL+D +EL S V
Sbjct: 13 LAAILAISQKMNSQRDLSELLDLIAREATSLLDCDRASIFLLDRDTNELWSKV------- 65
Query: 374 GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP 433
L D + +R +RGIAG+ A +G+T+N+ DAYSD RF +D TGY+T ++L +
Sbjct: 66 ALGSD---EILRFEASRGIAGNAARTGDTINVRDAYSDPRFYTGIDGKTGYRTRNLLAVA 122
Query: 434 IKVE-GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
++ + G++IG + +NKR + D+E + ++ +A+ A+L + R + +
Sbjct: 123 VRNQRGEIIGAFEALNKRVGVFTARDEE-SLAALASHAAVAIETAQLIGELRRNQDE 178
>UniRef50_A0C3Y8 Cluster: Chromosome undetermined scaffold_148,
whole genome shotgun sequence; n=6; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_148,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 594
Score = 85.0 bits (201), Expect = 8e-15
Identities = 57/164 (34%), Positives = 81/164 (49%), Gaps = 11/164 (6%)
Query: 328 VSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMP 387
V LD ++ I++ + DRAS F+VD EL + V IR+
Sbjct: 278 VLLDDALQNIIDKCVDCLECDRASCFIVDQAKKELWTRV----------AKGTSTTIRLQ 327
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMV 447
+ +G+AG VA + +NI DAY D RFN D YKT ++L PI K +GV+Q V
Sbjct: 328 MGQGLAGFVAQNHTILNIEDAYRDQRFNTQQDAKNNYKTKTLLVSPILDGDKCVGVLQCV 387
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYR 491
NK + +F DDEA +I + F L +A +D M + K R
Sbjct: 388 NK-SNGFFTKDDEALLQIMAEFSKSVLKNALNHDAQMLIQNKLR 430
>UniRef50_A0E2C5 Cluster: Chromosome undetermined scaffold_74, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_74,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 975
Score = 84.6 bits (200), Expect = 1e-14
Identities = 74/268 (27%), Positives = 117/268 (43%), Gaps = 8/268 (2%)
Query: 542 ISMFRDLFDMTQFDITTLTRFTLTV--KKNYRTVPYHNFDHGWTVAHAMYAIL-KSDVKE 598
I + +L + TL +F V K N + +HN+DHG +V ++AIL +
Sbjct: 688 ILKYHNLIKEYDIPLDTLCQFLSEVEYKYNKKKNVFHNYDHGVSVMQNVHAILLQLHQTS 747
Query: 599 RFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTI 657
++ AL ++ LCHD+ H G TN + + S LA Y S LE HH ++ +
Sbjct: 748 NAAIISTFNQFALLLSGLCHDVSHTGRTNTFEINSLSNLAIRYHDRSVLEQHHAAKSLKL 807
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPS 717
L NI E++++ IL TD+ F NL K E + E+ F D
Sbjct: 808 LCVPATNILQSFKGEEFRKFRRMFISNILYTDITEHF-NLIKNFE-SKVSESNFGQQDED 865
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP-MMDRNKP 776
+ L+ I T +D + AK +E+ + + +EF Q + E G +P M D K
Sbjct: 866 IKLLSGMIIHT-SDFTGGAKQFELSKQWSFKVNKEFEQQYELEGKLGYPQLPYMKDLQKL 924
Query: 777 EEQPASQVGFLSQICIPCYDMLYRILPN 804
+ GF I P + + + L N
Sbjct: 925 PVMAKQEAGFFKFIVRPLWQSMSKYLDN 952
>UniRef50_Q73KY8 Cluster: Sigma-54 dependent transcriptional
regulator, putative; n=1; Treponema denticola|Rep:
Sigma-54 dependent transcriptional regulator, putative -
Treponema denticola
Length = 505
Score = 84.2 bits (199), Expect = 1e-14
Identities = 51/174 (29%), Positives = 97/174 (55%), Gaps = 7/174 (4%)
Query: 309 ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFD 368
+R+ + L++ I L L+++I+E A +V D ASL +++ L F+
Sbjct: 8 KRDKLNTLINTSLLINSNYSDLSVLLEKIVESAMDVVEGDAASLLMLEPDGERLR---FE 64
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ P +E K++ + ++ GIAG V + I D SD RF+ V + TGYK +
Sbjct: 65 IAIGPK---GIEAKKMVLDLD-GIAGWVIKYNRSAIINDVLSDPRFDPTVQKVTGYKNRN 120
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR 482
++ +P++++ + IGV++++NKR++K F DD E+F+T +A +A+ Y++
Sbjct: 121 MIAVPMRIKDECIGVIEVLNKREEKDFDSDDLNVLELFATQTAIAYQNAKHYEK 174
>UniRef50_Q8I0P7 Cluster: Probable 3',5'-cyclic phosphodiesterase
pde-3; n=4; Caenorhabditis|Rep: Probable 3',5'-cyclic
phosphodiesterase pde-3 - Caenorhabditis elegans
Length = 578
Score = 84.2 bits (199), Expect = 1e-14
Identities = 79/309 (25%), Positives = 124/309 (40%), Gaps = 36/309 (11%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF------ 600
+LF + + F ++K Y +PYHN H V H Y + V+ F
Sbjct: 227 ELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIHAADVLHGCYYLSAHPVRSTFLTPKTP 286
Query: 601 -----------DYNKASSRL------ALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT 643
++ S+L ALF A HD DH G TN ++ + A +Y
Sbjct: 287 DSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHPGRTNAFLVQVEDKKAILYND 346
Query: 644 -STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRE 702
S LE+HH + +L + ++ ++ + K + ILATDL F + E
Sbjct: 347 RSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTE 406
Query: 703 LYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERA 762
+ Q D R L + + AD+++ KP+ + + I EEFY+QGD ER
Sbjct: 407 RLTEIDVQVETD----RLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERR 462
Query: 763 AGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDM-----LYRILP--NTKPMYAMATKN 815
G P MDR + Q F++ + P L ILP +T + N
Sbjct: 463 RGLPITPYMDRGDAQVAKL-QDSFIAHVVSPLATAMNECGLLPILPGLDTSELIINMEHN 521
Query: 816 LNRWKARAD 824
+WK + +
Sbjct: 522 HRKWKEQIE 530
>UniRef50_Q8CXS5 Cluster: CGMP-dependent 3',5'-cyclic
phosphodiesterase; n=4; Leptospira|Rep: CGMP-dependent
3',5'-cyclic phosphodiesterase - Leptospira interrogans
Length = 660
Score = 82.2 bits (194), Expect = 6e-14
Identities = 45/128 (35%), Positives = 84/128 (65%), Gaps = 11/128 (8%)
Query: 330 LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
+++L++ I+ A+ + AD SL+LV+ + + V +L+F+ +D++ +E +PIN
Sbjct: 163 INKLLREIIFSAREIAIADSGSLYLVE---KDELGLVRNLRFKIS-SMDIDTEEFLLPIN 218
Query: 390 RG-IAGHVALSGETMNIPDAY-----SDYRFNRDVDEATGYKTISILCMPIK-VEGKVIG 442
+ +AG+VA +G+ +NIPD Y S+Y+FNR+ D + Y T S+L +P+K +V+G
Sbjct: 219 KSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVG 278
Query: 443 VVQMVNKR 450
V+Q++NK+
Sbjct: 279 VIQLINKK 286
>UniRef50_Q83A76 Cluster: GAF domain protein; n=5; Coxiella
burnetii|Rep: GAF domain protein - Coxiella burnetii
Length = 254
Score = 82.2 bits (194), Expect = 6e-14
Identities = 50/155 (32%), Positives = 88/155 (56%), Gaps = 6/155 (3%)
Query: 330 LDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
+D +I++I+E + SL D + EL + GLD ++ K IR+
Sbjct: 26 VDTVIEKIMEEVENFFTPTNWSLLRYDSVDDELFFV-----YAKGLDEEIIKG-IRLKRG 79
Query: 390 RGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNK 449
GIAG VA +G+++ I D +D RF++ VD + KT SI+ +PIK + ++GV+++VN
Sbjct: 80 EGIAGTVAETGKSLFIRDCQNDPRFSKKVDRSFKQKTRSIITVPIKFKDVLLGVLELVNL 139
Query: 450 RDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
++ YF ++D EI + F +AL +A L++ ++
Sbjct: 140 ENNVYFSEEDCFLLEIVANFSAVALINASLFENVV 174
>UniRef50_Q04NN0 Cluster: Serine phosphatase RsbU, regulator of
sigma subunit; n=4; Leptospira|Rep: Serine phosphatase
RsbU, regulator of sigma subunit - Leptospira
borgpetersenii serovar Hardjo-bovis (strain JB197)
Length = 582
Score = 82.2 bits (194), Expect = 6e-14
Identities = 49/171 (28%), Positives = 89/171 (52%), Gaps = 6/171 (3%)
Query: 309 ERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFD 368
ER +S L+ + A +L++L+ I+E + ++N + SL L D LV +
Sbjct: 3 ERQLSLSLISNITAKINSTDNLEELLNIIIETTKDVLNTEGCSLLLYDRNEDCLVFNIAK 62
Query: 369 LKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
E L E+++P +GIAG V + E + + DA +D R R++DE G+ T +
Sbjct: 63 GTKEKSLT------ELKVPRGKGIAGMVLETLEPVIVNDAKNDPRIYRNIDETVGFVTYN 116
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
++C+P+ +G++ GV++ VN + K F + D + S +A+ + RL
Sbjct: 117 LICVPMSTQGEIQGVLEAVNSLERKEFTNKDIKILQYLSDLAAIAIRNRRL 167
Score = 58.8 bits (136), Expect = 6e-07
Identities = 56/236 (23%), Positives = 107/236 (45%), Gaps = 19/236 (8%)
Query: 259 ITKSGKTSYVLEMWRTKDR--FKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFL 316
++ G+ VLE + +R F D +I ++ ++A+ +L D K N D L
Sbjct: 122 MSTQGEIQGVLEAVNSLERKEFTNKDIKILQYLSDLAAIAIRNRRLIRDLKSRANELDCL 181
Query: 317 LDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLD 376
+ +AI + +DQ + ++ A+R SL + +N + ++LK G
Sbjct: 182 FQLSQAI-SNISEMDQFFNLTVNSVSEIMGAERVSLIFFNPKNGK-----YELKKSIGFS 235
Query: 377 LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKV 436
L E+ I G+ V +G+ + + + S D YKT S + +PI+
Sbjct: 236 LKEEEHFINE--KEGVIRKVIETGKPILVQNTSS---IMEDCVRPERYKTKSFISVPIRQ 290
Query: 437 EGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRV 492
+GK+IG++ +K+ F + D+ + ST ++ A Y+ ++ KEQK ++
Sbjct: 291 DGKIIGILNSADKKSGNNFDNADQ---NVLST---ISNQIAEAYNSLLSKEQKEKL 340
>UniRef50_A2E4B2 Cluster: Response regulator receiver domain
containing protein; n=1; Trichomonas vaginalis G3|Rep:
Response regulator receiver domain containing protein -
Trichomonas vaginalis G3
Length = 637
Score = 82.2 bits (194), Expect = 6e-14
Identities = 62/226 (27%), Positives = 110/226 (48%), Gaps = 20/226 (8%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLC 617
+ F ++++ P+HNF ++A +A ++ S KER +A++ L A L
Sbjct: 309 IEHFLQKTQQSFNLNPFHNFRR--SIAGLQFATMILSKYKERVPPFEAAAGL---FAALL 363
Query: 618 HDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSH-ISSEDYK 675
HD+ H G N + T+S LA +Y S LE + ++ ++Q+ +FS I +D+
Sbjct: 364 HDIGHPGTNNMFQIRTSSQLALIYNDKSVLEMNSASVGARLVQE----VFSFSIDDQDFS 419
Query: 676 EILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSAS 735
+ +LATD + L K L ++ + W++ HR +A+ + +DLS +
Sbjct: 420 TLRATFLSNVLATD----YSKLQKF--LAKAANIKMDWENKEHRQIALQLLTLMSDLSFA 473
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDR--NKPEEQ 779
+ W+ ++ +E Y QGD ER IP+MDR N+P +
Sbjct: 474 IRNWKTTSYWYGMMRDEHYIQGDMERKRNMKSIPLMDRRANRPNTE 519
>UniRef50_Q57ZK5 Cluster: 3', 5'-cyclic nucleotide
phosphodiesterase, putative; n=1; Trypanosoma
brucei|Rep: 3', 5'-cyclic nucleotide phosphodiesterase,
putative - Trypanosoma brucei
Length = 909
Score = 81.8 bits (193), Expect = 8e-14
Identities = 62/239 (25%), Positives = 103/239 (43%), Gaps = 7/239 (2%)
Query: 566 VKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGY 625
++ NYR P+HN V A+++ L S K + AL A + D+ H G
Sbjct: 356 IENNYRPNPFHNAVRAADVVQAVFS-LASATKPLMRHVTLVELKALVFAAVALDVRHPGR 414
Query: 626 TNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHC 684
TN+++ T PL Y TLE H +++ N ++ E + +
Sbjct: 415 TNEFLVRTCDPLCYRYPGPGTLEQMHVATAFQLVEVPELNFTCRMNDESFLRFKTIVSKL 474
Query: 685 ILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIK 744
I TD A +L+ R ++ E F + P R A+++ + AAD ++ +I K
Sbjct: 475 ICRTDTAVLEDHLEHWRA--KAREGGFDYGAPDDRVDALSLLLLAADFGVISRGADIAAK 532
Query: 745 TVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
+ V+ EE Q +ER G P D P SQ+ FL + IP ++ + ++ P
Sbjct: 533 WL-VLTEEHAAQAQEERRRGLPVTPGFD--LPTSVGRSQIAFLDSVVIPLFNQVQQLFP 588
>UniRef50_A6C1F0 Cluster: Probable two-component response regulator;
n=1; Planctomyces maris DSM 8797|Rep: Probable
two-component response regulator - Planctomyces maris
DSM 8797
Length = 673
Score = 81.4 bits (192), Expect = 1e-13
Identities = 49/172 (28%), Positives = 95/172 (55%), Gaps = 11/172 (6%)
Query: 320 VKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDM 379
+ + F L++ I + A RL+ ++R+S+F+ D + ++V+ P L +
Sbjct: 182 IASSFSSARETQPLLELIAKEATRLLESERSSIFIWDREHKQVVAC-------PALGV-- 232
Query: 380 EKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-G 438
E +R+P + GI G V SG+T+ + DAY+D RF+ VD+++G++T ++LC+P++ G
Sbjct: 233 EGNTLRLPDDVGIVGDVIHSGKTICVDDAYNDERFDPSVDKSSGFRTHNLLCVPLRNNAG 292
Query: 439 KVIGVVQMVNKRDDKY-FGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
++IG +++NK K + D D + E AL + R +++ R +
Sbjct: 293 ELIGAFEVMNKEKGKADYDDADAQSLEELGVQAATALENTREIEQLSRSRDQ 344
>UniRef50_Q3UEI1-2 Cluster: Isoform 2 of Q3UEI1 ; n=1; Mus
musculus|Rep: Isoform 2 of Q3UEI1 - Mus musculus (Mouse)
Length = 652
Score = 81.0 bits (191), Expect = 1e-13
Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 6/155 (3%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + LT++ +Y + V YHN H V + + +L +
Sbjct: 351 IFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVAYHNSMHAADVVQSAHVLLGTPAL 410
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + A+F AC HD+DH G +N+++ T S LA MY +S LE+HH +
Sbjct: 411 EAV-FTDLEVLAAIF-ACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFK 468
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
+LQ + +IF ++S++ + + +LATD++
Sbjct: 469 LLQGENCDIFRNLSTKQRLSLRRMVIDMVLATDMS 503
>UniRef50_Q1JT10 Cluster: Phosphodiesterase, putative; n=2;
Eukaryota|Rep: Phosphodiesterase, putative - Toxoplasma
gondii RH
Length = 2092
Score = 80.6 bits (190), Expect = 2e-13
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 39/375 (10%)
Query: 486 KEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMF 545
K +K ++ L + + E + K+ + F + LD +R + E +
Sbjct: 1667 KRRKRASSVPSLVFSAALEKCERHMKAIRKDLVLAQFRGWNLDIWRRNSSEMEIFFLLAL 1726
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
DL + + + L F ++ Y T PYHNF H V + L +
Sbjct: 1727 DDLGLLERREEKKLRHFFAIIRDGYHTDNPYHNFYHAIHVFQVCWMFLSAYGCRNI--LS 1784
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITV-TILQQDG 662
+L + +A LCHD+DH G N ++ + PL+ MY S LE+HH + T++Q
Sbjct: 1785 PIEQLGILLAALCHDVDHPGVNNAFLRASLHPLSIMYNDKSVLENHHAAFAIRTMMQLGM 1844
Query: 663 HNIFSHI----------SSED-----------------YKEILGFIRHCILATDLAAFFP 695
+ S I +S D + E+ + I +TD+ F
Sbjct: 1845 YGAGSRIFPSGSGAAAPASPDGKSGSSGSRFEGRIVPSFSELRKIVIQAIFSTDMELFRQ 1904
Query: 696 NLDKIR---ELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEE 752
+ D ++ ++ +D + +D R+L + + AD+ ++ ++ +E
Sbjct: 1905 HHDAMKRRAQMKTNDREELEGEDD--RNLLVTCLIHCADICNPVMSEGRNVQWASLVTQE 1962
Query: 753 FYDQGDKERAAGRIPIPM-MDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAM 811
F Q D ER G +P+ + MD ++ SQ+GFLS + + + L ++P +
Sbjct: 1963 FNAQVDLERRYG-LPVSVFMDARTELQRTQSQIGFLSFVVLDQFRALADLIPEVSELVVQ 2021
Query: 812 ATKNLNRWKARADKI 826
KNL W+ D +
Sbjct: 2022 GEKNLEMWQRALDTL 2036
Score = 44.4 bits (100), Expect = 0.014
Identities = 40/161 (24%), Positives = 77/161 (47%), Gaps = 16/161 (9%)
Query: 302 LYVD-KKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
LYV+ KRER L++ +++F+E ++ + ++R L + ++A+ F+VD +N+
Sbjct: 1067 LYVEWLKRERTKKALQLELHRSVFQEALNPIKTVERFLSLIHTTLGVEQAAFFIVDAQNN 1126
Query: 361 ELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDE 420
V LK GL L + +G G +A+ + +P N + D+
Sbjct: 1127 SFVCLGGALKAR-GLTLPYSHPLLGEATRQG--GRIAICND---VPPC-----MNGEYDD 1175
Query: 421 ATGYKTISILCMP-IKVEGKVIGVVQMVNK---RDDKYFGD 457
+T S + +P + +G V GV+ ++N+ R +GD
Sbjct: 1176 LARIRTQSAMVVPLLNAQGFVKGVLLLMNRSASRQQLSYGD 1216
>UniRef50_Q53S13 Cluster: Putative uncharacterized protein PDE11A;
n=4; Deuterostomia|Rep: Putative uncharacterized protein
PDE11A - Homo sapiens (Human)
Length = 125
Score = 80.6 bits (190), Expect = 2e-13
Identities = 37/102 (36%), Positives = 58/102 (56%), Gaps = 1/102 (0%)
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVG 785
MTA DL A KPWEI + +++ EF++QGD+ER ++ P + DRN+ +E P Q+
Sbjct: 4 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 63
Query: 786 FLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKIL 827
++ IC+P Y L ++ KPM N ++W+ K L
Sbjct: 64 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRL 105
>UniRef50_UPI00006CA67B Cluster: GAF domain containing protein; n=1;
Tetrahymena thermophila SB210|Rep: GAF domain containing
protein - Tetrahymena thermophila SB210
Length = 932
Score = 79.8 bits (188), Expect = 3e-13
Identities = 52/174 (29%), Positives = 100/174 (57%), Gaps = 18/174 (10%)
Query: 300 CKLYVDKKRER--NMSDFLLDVVKAIFEEMVSLD--QLIKRILEFAQRLVNADRASLFLV 355
C LY + + ++++ L +++ AI + +S++ + I++ ++ DRAS+FLV
Sbjct: 553 CLLYTLESSDLFFHLTNKLKNLINAIIKIHLSVEINEAFSIIVKECCNVLECDRASVFLV 612
Query: 356 DYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFN 415
+ + SEL + + + G+ I++P +G+ G VA + + +NI DA+ D RFN
Sbjct: 613 NPQTSELWTKIAK---DSGV--------IKVPFGQGLVGFVANTMKPLNILDAHKDSRFN 661
Query: 416 RDVDEATGYKTISILCMPI--KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFS 467
++D+ Y T S+LC+P+ +G ++GV+Q +NK +D +F DDE +I +
Sbjct: 662 PEIDKKNNYLTKSVLCVPVIDSDKGNLVGVMQAINK-NDGFFTKDDEGCLQIMA 714
Score = 44.8 bits (101), Expect = 0.011
Identities = 45/209 (21%), Positives = 95/209 (45%), Gaps = 18/209 (8%)
Query: 247 NKQGNY----ILYQPII-TKSGKTSYVLEMWRTKDRFKVIDEEISGHIVVWGSVALHYCK 301
+K+ NY +L P+I + G V++ D F D+E I+ + ++ +
Sbjct: 665 DKKNNYLTKSVLCVPVIDSDKGNLVGVMQAINKNDGFFTKDDEGCLQIMAYHAMNVLRTS 724
Query: 302 LYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSE 361
+ +D+K++ L + ++L+ L+ + Q ++ +FLVD S+
Sbjct: 725 ISIDQKQKNQSMIKNLLHLSIKLGNCITLETLVSKSRNMIQSYLDVGEFKIFLVDKEKSK 784
Query: 362 LVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
L F + ++ E++E + G+ GH + + I +AY+ FN+ VD
Sbjct: 785 L----FTINYQN------EREEFELSC--GLIGHCLSLKQDLTIDNAYNHTNFNQLVDIN 832
Query: 422 TGYK-TISILCMPIKVEGKVIGVVQMVNK 449
T + I+ K + +++GV+Q++N+
Sbjct: 833 TSMPLCMYIIWDNPKKKNQILGVIQVINQ 861
>UniRef50_A5UTQ7 Cluster: Sensor protein; n=1; Roseiflexus sp.
RS-1|Rep: Sensor protein - Roseiflexus sp. RS-1
Length = 711
Score = 79.8 bits (188), Expect = 3e-13
Identities = 45/167 (26%), Positives = 86/167 (51%), Gaps = 7/167 (4%)
Query: 317 LDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLD 376
L+ + ++ + ++ + +++ + + SL LVD +L F + E G
Sbjct: 185 LNDIASVVTSTLDTREVYRLVVQQLSDYFHVEAGSLLLVDEATGDLE---FVMTIEGG-- 239
Query: 377 LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKV 436
+ + R+P +G+ GHV +G + D D RF R + EATG+ T SILC+P+
Sbjct: 240 -EEKLAGFRVPAGQGVVGHVVRTGRWEIVHDVSRDPRFYRQISEATGFSTRSILCVPMIA 298
Query: 437 EGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
+G+VIG ++++NK F ++D + F +A+ +ARL+ ++
Sbjct: 299 KGRVIGAIELLNKIGGD-FDEEDALRLMRMAAFIAVAIENARLFQQV 344
>UniRef50_A1D4A4 Cluster: High affinity cAMP phosphodiesterase,
putative; n=8; Trichocomaceae|Rep: High affinity cAMP
phosphodiesterase, putative - Neosartorya fischeri
(strain ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 1009
Score = 79.4 bits (187), Expect = 4e-13
Identities = 87/352 (24%), Positives = 145/352 (41%), Gaps = 38/352 (10%)
Query: 524 DFYLDPFRFDE--FEKCKCIISMFRDLFDMTQFDITT--LTRFTLTVKKNYRT-VPYHNF 578
+F F DE F C+ + F L ++ Q+ +T L F L + +Y + V YHNF
Sbjct: 308 NFTAHEFSEDELVFGACEMLQHAFT-LPNLDQWRLTPCELRTFLLACRASYNSFVLYHNF 366
Query: 579 DHGWTVAHAMYAILK--------SDVKERFDYNKASSRL-------ALFVACLCHDLDHR 623
H V +++ L V D + + L L ++ + HD+ H
Sbjct: 367 RHAIDVLQSVFCFLVHIGALPPYGSVGTSPDSPSSIASLLTPFDTLTLLISAIGHDVGHP 426
Query: 624 GYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIR 682
G N ++ + +PLA +Y S LE H IL++ F +++ +
Sbjct: 427 GVNNFFLVKLNAPLAQLYNDNSVLEAFHCAAFSQILRRHWPAAFKD------RQLRKLLI 480
Query: 683 HCILATDLAA---FFPNLDKIRE-LYRSDEAQFSW---DDPSHRDLAMAISMTAADLSAS 735
ILATD+ F L ++E Y + ++ W D ++ L + + AD+S
Sbjct: 481 SSILATDMGVHQKFMERLGSLQEKFYANGKSVDGWKPQDIEIYKTLVCGLLIKCADISNV 540
Query: 736 AKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM---MDRNKPEEQPASQVGFLSQICI 792
A+PW+I K K++ EEF +QG+ ER G + + Q+GF+S +
Sbjct: 541 ARPWDIAEKWTKILQEEFANQGEMEREVGMETALFGGPPELGNVYKLATGQIGFMSIFAL 600
Query: 793 PCYDMLYRILPNTKPMYAMATKNLNRWKARADKILFKQXXXXXXXXXXLEPK 844
P ++ + +LP + N RW AD KQ L P+
Sbjct: 601 PLFEGVSDLLPELRFTVEHIRTNQTRWHFLADMEKRKQSLLDPRFEGGLSPR 652
>UniRef50_Q1DXU2 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 900
Score = 79.0 bits (186), Expect = 5e-13
Identities = 83/334 (24%), Positives = 147/334 (44%), Gaps = 40/334 (11%)
Query: 524 DFYLDPFRFDEFEKCKCI-ISMFRDLFDMTQFDITT--LTRFTLTVKKNYRT-VPYHNFD 579
+F F DE C+ + L ++ Q+ ++ + F L+V+ +Y + V YHNF
Sbjct: 309 NFLSHEFSDDELVHAACVMVEHALQLPELEQWRLSPEEIRSFLLSVRASYNSFVLYHNFR 368
Query: 580 HGWTVAHAMYAIL-KSDVKERFDYN--KASSR------------LALFVACLCHDLDHRG 624
H V +++ L K + F + S+R L L + + HD+ H G
Sbjct: 369 HAIDVLQSVFHFLVKIGILPPFPLGSEEVSTRSGMSSILTPFDALTLLITAIGHDVGHPG 428
Query: 625 YTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
N ++ + +PLA +Y S LE H IL++ ++F + +
Sbjct: 429 VNNVFLVKLNAPLAQLYNDKSVLEAFHCAAYSQILRRHWPSVFKD------NRLRKLMID 482
Query: 684 CILATDLA---AFFPNLDKIRELYRSDE-AQFSW---DDPSHRDLAMAISMTAADLSASA 736
ILATD+ F +L K+++ YRS+ + W D ++R L A+ + AD+S A
Sbjct: 483 SILATDMGIHNVFMESLGKLQQSYRSNNRTTWGWEPKDIDTYRTLLCALLIKCADISNVA 542
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPE-----EQPASQVGFLSQIC 791
+P+ I K ++ EF +QG E G + PE ++ Q+GF++
Sbjct: 543 RPFHIAEKWTDILQLEFANQGMMEAEIGM--ETALFGGPPELGNFVKKANGQIGFMNVFA 600
Query: 792 IPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
+P +D + +LP+ +N RW+ D+
Sbjct: 601 LPLFDGVADVLPDMAFAANEIRRNKCRWQMSVDR 634
>UniRef50_Q8F3G8 Cluster: Sigma factor sigB regulation protein rsbU;
n=4; Leptospira|Rep: Sigma factor sigB regulation
protein rsbU - Leptospira interrogans
Length = 938
Score = 78.2 bits (184), Expect = 1e-12
Identities = 54/184 (29%), Positives = 94/184 (51%), Gaps = 11/184 (5%)
Query: 304 VDKKRERNMSDFLLDV---VKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
V +++ + DFLL V + + + L QL++ I+ ++ + + S+ L+D
Sbjct: 189 VQIRKQTDRFDFLLTEIIRVSGLINKSLDLSQLLEAIMLSSKSVFRTEACSVLLLDDTKE 248
Query: 361 ELV-STVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVD 419
L TV K + E ++++P+ +GIAG V + M I DA +D R R+VD
Sbjct: 249 YLYFHTVLGEKRD-------EVTKVKVPVGKGIAGMVVQDKKPMIINDAMNDPRVYREVD 301
Query: 420 EATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
+A+ + T +I+ P+ VEG+VIGV++ +N D F ++D F FS LA+ L
Sbjct: 302 KASHFVTRNIMAAPLLVEGQVIGVIETINTIDRNSFTEEDLELFLSFSGTSALAIQKTGL 361
Query: 480 YDRI 483
+
Sbjct: 362 LQNL 365
>UniRef50_Q73JB6 Cluster: GAF domain/HD domain protein; n=1;
Treponema denticola|Rep: GAF domain/HD domain protein -
Treponema denticola
Length = 417
Score = 77.4 bits (182), Expect = 2e-12
Identities = 56/187 (29%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 305 DKKRERNMSDFLLDVVK--AIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSEL 362
+K +E + L+ +++ ++ + +D L+++IL A+ +VNAD S+++ + +
Sbjct: 5 NKYKELSKEQILIKILETESLIHSVQDVDVLLEQILTEARSVVNADAGSIYIAEGDRLAI 64
Query: 363 VSTVFD-LKFEPGLDLDMEKKEIRMPI-NRGIAGHVALSGETMNIPDAYS-----DYRFN 415
D L+ + + PI N IAG+ A + + +NIPD Y+ ++F
Sbjct: 65 RYAQNDTLQKKRPAGTKLPYIFFDFPIDNYTIAGYAANTKKLINIPDVYNIDADKPFKFG 124
Query: 416 RDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRD----DKYFGDDDEAAFEIFSTFF 470
+ DE TGYKT+S L +PI + G ++GV+Q++N D K F DDE F++
Sbjct: 125 KATDEKTGYKTVSNLTIPILSMSGMLLGVLQVLNALDKYGKPKTFSHDDEIYLSHFASNA 184
Query: 471 GLALHHA 477
G+AL HA
Sbjct: 185 GIALEHA 191
>UniRef50_A7AVW3 Cluster: cAMP-specific phosphodiesterase, putative;
n=1; Babesia bovis|Rep: cAMP-specific phosphodiesterase,
putative - Babesia bovis
Length = 525
Score = 77.4 bits (182), Expect = 2e-12
Identities = 43/166 (25%), Positives = 92/166 (55%), Gaps = 15/166 (9%)
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
R+ +D LL ++ ++F + + + + + A++L+ A+R ++++VD + +L S D
Sbjct: 321 RDKADGLLTLMHSLFADRLGIQSCVVALTTHARKLIQAERCTVYIVDRSHDQLWSISSD- 379
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
+ ++ +P+++G A +G+ + I +A+ D RFN + D G + ++
Sbjct: 380 ----------DGSQVIVPLSQGCASSCVQNGDVIVIENAFEDERFNPEFDSRAGVEIRNV 429
Query: 430 LCMPIKVE--GKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFG 471
+PIK +V+ V++++NK+ D+ +FG+DD EIFS+ G
Sbjct: 430 AWVPIKSGDCNRVLAVIEVINKQADELLHFGEDDLRLLEIFSSIVG 475
>UniRef50_Q0LHC9 Cluster: Metal-dependent phosphohydrolase, HD
subdomain; n=1; Herpetosiphon aurantiacus ATCC
23779|Rep: Metal-dependent phosphohydrolase, HD
subdomain - Herpetosiphon aurantiacus ATCC 23779
Length = 571
Score = 77.0 bits (181), Expect = 2e-12
Identities = 57/187 (30%), Positives = 101/187 (54%), Gaps = 21/187 (11%)
Query: 306 KKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVST 365
++RE +S L+++V I + L+ I+++A+ L++A+ +SLFL + + +L+
Sbjct: 174 QQRESRLSA-LVEIVGHIGSTL-DRTTLLNLIIDYARILLDAEASSLFLTEPESGDLI-- 229
Query: 366 VFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYK 425
L+ G L + +R+ RGIAG+VA +GET+ + D D R + VD+ TG++
Sbjct: 230 ---LQHSTG-HLHERVQSVRLAKGRGIAGYVAETGETICVGDVKRDQRHDGSVDQMTGFE 285
Query: 426 TISILCMPIKV------------EGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLA 473
T SIL +P++ E +IG ++++NKRD + F DDD+ + +
Sbjct: 286 TRSILAVPLRTRCITFGRERAQSEEHLIGCIEVLNKRDGR-FDDDDKLLLQTLARQAATV 344
Query: 474 LHHARLY 480
L A LY
Sbjct: 345 LEIADLY 351
Score = 57.6 bits (133), Expect = 1e-06
Identities = 40/172 (23%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 328 VSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMP 387
++LD L+ R+L + + +L+LVD + E+V V G +R+P
Sbjct: 31 MTLDPLLDRMLALLIEIAGGEAGTLYLVD--DDEIVFQVVH-----GDPASQHLVGMRLP 83
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMV 447
IN G+ G + + + I D +D R++R + EA + S+L +P+ +E +V+GV+Q+
Sbjct: 84 INIGLVGATIRAAQPLWIEDINADPRWDRRLGEANSLQLRSLLSLPLLLEEQVVGVIQIF 143
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSY 499
N + + ++ + ARL + ++E + +E++ +
Sbjct: 144 NPQ------RSEPRLLKLLGNRMAAEVEKARLLKKSQQRESRLSALVEIVGH 189
>UniRef50_A2EE12 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 1019
Score = 77.0 bits (181), Expect = 2e-12
Identities = 37/103 (35%), Positives = 59/103 (57%), Gaps = 1/103 (0%)
Query: 381 KKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP-IKVEGK 439
+K I+M I GIAG+VA +G+ +N+ +A FN +DE TGY T +++ P I G+
Sbjct: 435 RKPIKMKIGEGIAGYVAQTGQELNLSNAADSSHFNPSIDEMTGYTTRTLMSTPIINTFGE 494
Query: 440 VIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR 482
V GV+Q++NK D+ F D ++ T +H+ L D+
Sbjct: 495 VHGVIQLINKMDNMPFSKRDSLIATVYGTLCTYMIHNQNLQDQ 537
>UniRef50_UPI0001554EBF Cluster: PREDICTED: similar to cyclic
nucleotide phophodiesterase, partial; n=1;
Ornithorhynchus anatinus|Rep: PREDICTED: similar to
cyclic nucleotide phophodiesterase, partial -
Ornithorhynchus anatinus
Length = 340
Score = 76.6 bits (180), Expect = 3e-12
Identities = 45/151 (29%), Positives = 74/151 (49%), Gaps = 3/151 (1%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 190 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLFLSRPEYNFL 249
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS-DEAQFSWDDPSHRDLAMAI 725
S++ ++K + ILATDL F L + + + W + + R L +
Sbjct: 250 SNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSSGIEWSNENDRLLVCQV 309
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQ 756
+ AD++ AK ++ +K + I EFY+Q
Sbjct: 310 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQ 340
>UniRef50_A6GDL8 Cluster: Sigma-54 dependent transcriptional
regulator, Fis family protein; n=1; Plesiocystis
pacifica SIR-1|Rep: Sigma-54 dependent transcriptional
regulator, Fis family protein - Plesiocystis pacifica
SIR-1
Length = 590
Score = 76.6 bits (180), Expect = 3e-12
Identities = 51/154 (33%), Positives = 82/154 (53%), Gaps = 11/154 (7%)
Query: 328 VSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMP 387
V LD L+ +++ ++A+R +L+LVD R+ L S V L E + IR+
Sbjct: 80 VELDALLVTVVDSIVEHLDAERGTLYLVDGRSRTLTSVVAHLP---------ELERIRLD 130
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQM 446
+G+AG VA G+ + + D +D RF+ +D TG+ T S+L +PI+ G+VIGV+Q+
Sbjct: 131 FGQGVAGTVAAQGQIIAVSDPGADPRFDASIDRQTGFSTRSMLALPIRDSAGEVIGVLQL 190
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+N + F D+A +T G L LY
Sbjct: 191 LNAGRGQ-FTLADQAKATTLATSAGQVLQATSLY 223
>UniRef50_Q1IL10 Cluster: Serine phosphatase; n=1; Acidobacteria
bacterium Ellin345|Rep: Serine phosphatase -
Acidobacteria bacterium (strain Ellin345)
Length = 584
Score = 75.8 bits (178), Expect = 5e-12
Identities = 51/196 (26%), Positives = 101/196 (51%), Gaps = 13/196 (6%)
Query: 294 SVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLF 353
++ + +LY + S LL+ + +++LDQL+KR+ E R+++ S+
Sbjct: 156 AIGIENARLYTRVSNQAK-SLLLLNEISRELTSILNLDQLLKRVGELLTRVIDYQMFSIL 214
Query: 354 LVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYR 413
L+D +L F L+F+ + L K +I P+ RG+ G+ E + +PD D R
Sbjct: 215 LLDPMGEKLQHR-FSLRFQENIHL---KHDI--PLGRGLVGYAVGKNEAVLVPDVRKDSR 268
Query: 414 FNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLA 473
+ +T S L +P+ +GKVIGV+ + + + +F +D + + +A
Sbjct: 269 Y-----IMLNPETRSELAVPLVYKGKVIGVLDLEHTKRG-FFTEDHKRTLTTLAAQIAIA 322
Query: 474 LHHARLYDRIMRKEQK 489
+ +ARLY++I+++E++
Sbjct: 323 IENARLYEQIVKQERR 338
Score = 56.0 bits (129), Expect = 4e-06
Identities = 42/182 (23%), Positives = 86/182 (47%), Gaps = 13/182 (7%)
Query: 315 FLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPG 374
FLL+V + + LD L+ R+ ++++N D ++ LV+ + EL ++F+ G
Sbjct: 13 FLLEVADVV-NTTLDLDTLLTRVAGLVRKIINYDIFAILLVNEKAQEL-----RIRFQVG 66
Query: 375 LDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI 434
+ ++ R+ I +GI G A + E + + D + V + S L +P+
Sbjct: 67 HPAEAIERT-RIKIGQGITGAAAQTREPVLVNDVSKHPEYITSVSDVR-----SELAIPM 120
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVAL 494
V+ KVIGV+ + YF ++ + ++ + + +ARLY R+ + + +
Sbjct: 121 IVKNKVIGVID-IEAPQKNYFTEEHSRLLTVIASRVAIGIENARLYTRVSNQAKSLLLLN 179
Query: 495 EV 496
E+
Sbjct: 180 EI 181
>UniRef50_Q0LNF0 Cluster: Sensor protein; n=1; Herpetosiphon
aurantiacus ATCC 23779|Rep: Sensor protein -
Herpetosiphon aurantiacus ATCC 23779
Length = 677
Score = 75.8 bits (178), Expect = 5e-12
Identities = 48/190 (25%), Positives = 93/190 (48%), Gaps = 7/190 (3%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
D +RN L+ + A + Q+ + +++ + SL L+D +ELV
Sbjct: 159 DYTAKRNQEINTLNDIAATITSSLDPRQVYRLVVKKINEYFQVEAGSLLLLDPVTNELV- 217
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
F + E G + + +R+P +G+ G + + + + DA +D RF R V E G+
Sbjct: 218 --FVMTLEAG---EEKLAGVRVPPGQGLVGAAITTRQPVVVLDAQNDPRFYRRVSEDVGF 272
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
T S+LC+P+ V+ + IGV+Q++NK + F +D + + G+A+ +A L+ +
Sbjct: 273 VTRSVLCVPMLVKNREIGVIQLLNKLEG-VFNTEDTQRLQAMANTVGVAIDNANLFHEVS 331
Query: 485 RKEQKYRVAL 494
+ + + L
Sbjct: 332 QNRNRLQALL 341
>UniRef50_A4LZ56 Cluster: Diguanylate cyclase with GAF sensor; n=3;
Geobacter|Rep: Diguanylate cyclase with GAF sensor -
Geobacter bemidjiensis Bem
Length = 704
Score = 75.8 bits (178), Expect = 5e-12
Identities = 50/184 (27%), Positives = 99/184 (53%), Gaps = 9/184 (4%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
++ +E +S L+ + + + + S D+L + ILE A L++A + S+ L+D ++ + +
Sbjct: 329 EQSKENALSQRLMSLTNTLLQ-VDSKDELYQAILEIAAELIDAMQGSVMLID-KDGQNMH 386
Query: 365 TVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGY 424
VF L G+ L++ + + + + +GIAG VA SG+ + + D D R + +
Sbjct: 387 IVFTL----GMTLNIARC-LPVKVGKGIAGMVAQSGQPLLVNDVEKDSRVA--MANRLRF 439
Query: 425 KTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
K+ S++CMP+K++ K+IGV+ + +K++ F D D F+ L + + +
Sbjct: 440 KSKSLICMPLKLKDKIIGVLNLSDKKNLAPFTDADLQVLTSFANLASLMIERTEVLEESE 499
Query: 485 RKEQ 488
R EQ
Sbjct: 500 RFEQ 503
>UniRef50_A5UV73 Cluster: Metal dependent phosphohydrolase; n=4;
Chloroflexaceae|Rep: Metal dependent phosphohydrolase -
Roseiflexus sp. RS-1
Length = 565
Score = 75.4 bits (177), Expect = 7e-12
Identities = 54/190 (28%), Positives = 96/190 (50%), Gaps = 21/190 (11%)
Query: 303 YVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSEL 362
Y ++R+R ++D + A + QL+ I+++A+ L+N + S++ +D +S+
Sbjct: 176 YRRERRQRALAD-----IAARLTTTLDRQQLLTLIMDYARDLLNCEATSVWEID--DSDE 228
Query: 363 VSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEAT 422
+ V G + I +P+ +GI GHV +G+ + + + D R + VD+ +
Sbjct: 229 TNPVVRSHVATG-SRGEQVTGITVPLGQGIIGHVVATGQIVRVDNVREDARHYQAVDQQS 287
Query: 423 GYKTISILCMPI------------KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFF 470
G+ T SILC+P+ +VE ++IG Q +NK D F DDD + FE F+
Sbjct: 288 GFVTRSILCVPLRAPGIELGAGRGRVEARIIGGAQALNKIDGA-FTDDDVSLFESFANLS 346
Query: 471 GLALHHARLY 480
L +RLY
Sbjct: 347 ATVLQLSRLY 356
Score = 74.9 bits (176), Expect = 9e-12
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPI 388
+L L+ R L+ A+ +L+L D ELV V G + +R+P
Sbjct: 26 NLAALLDRTLDLFVEEARAEAGTLYLYDPERDELVFHVVK-----GDETSQRLLGMRIPA 80
Query: 389 NRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVN 448
NRG+AG + E + + D SD R++R + E + ++ C+P+ +E + +GVVQ+ N
Sbjct: 81 NRGVAGAALRTREPIFVSDVTSDSRWDRSIGELASIRLRTMYCLPLMIEERPVGVVQVFN 140
Query: 449 KRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEV 496
DD +++ A I + RL + R+E++ R ++
Sbjct: 141 LPDDAVDAEEELALLRILGNTMVSVIDKTRLLEETYRRERRQRALADI 188
>UniRef50_Q2LUL4 Cluster: General secretion pathway protein E; n=1;
Syntrophus aciditrophicus SB|Rep: General secretion
pathway protein E - Syntrophus aciditrophicus (strain
SB)
Length = 784
Score = 74.9 bits (176), Expect = 9e-12
Identities = 49/180 (27%), Positives = 93/180 (51%), Gaps = 19/180 (10%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPI 388
++ Q++ + E L +A ++++VD +E+ S + + KEIR+PI
Sbjct: 57 NIKQILVDLKEGILNLFDAYSITIYVVDRLRNEIFSLLLSAS---------QIKEIRVPI 107
Query: 389 N-RGIAGHVALSGETMNIPDAYS---------DYRFNRDVDEATGYKTISILCMPIKVEG 438
N + IAG+VA + +T+NI DAY + F+ D+ TG+++ ILC P+ G
Sbjct: 108 NNKSIAGYVANNKKTVNIADAYDVAELRQIDPELSFDLSWDKKTGFRSRQILCSPVFYNG 167
Query: 439 KVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS 498
K+ GV+Q++NK+ F D++ + + G+A + Y R + Y ++ ++L+
Sbjct: 168 KLSGVIQILNKKGGGKFSDEEVGFVQEIAEVLGVAFFNQERYARRRKTRYDYLISRDLLT 227
>UniRef50_Q31LP1 Cluster: GAF; n=2; Synechococcus elongatus|Rep: GAF
- Synechococcus sp. (strain PCC 7942) (Anacystis
nidulans R2)
Length = 195
Score = 74.5 bits (175), Expect = 1e-11
Identities = 45/133 (33%), Positives = 72/133 (54%), Gaps = 11/133 (8%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLV--DYRNSELVSTVFDLKFEPGLDLDMEKKEIRM 386
S D + L+ A L AD S+F + D R EL+ ++ +P + L I
Sbjct: 27 STDAALSLFLDTAIALTQADAGSIFQLRWDLRGPELICSLARNFSQPDIQLQGNPLPI-- 84
Query: 387 PINRGIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYKTISILCMPIKVEGK-V 440
+ +AG+VA +GE +N+PD Y Y F VD ATGY+T SIL +P+K + +
Sbjct: 85 -LRNSLAGYVATTGEVLNVPDVYQLPLGLPYHFQPRVDSATGYRTQSILVLPLKTARQDI 143
Query: 441 IGVVQMVNKRDDK 453
IG+V+++N++ D+
Sbjct: 144 IGIVELINRKCDR 156
>UniRef50_A4VD13 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 319
Score = 74.5 bits (175), Expect = 1e-11
Identities = 42/127 (33%), Positives = 73/127 (57%), Gaps = 14/127 (11%)
Query: 344 LVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETM 403
+++ D++S+FL+D +++ L + G DM K + G GHVA +G+T+
Sbjct: 17 ILSCDKSSIFLLDEKSN--------LFWTKGNKNDMIKLSVDQS---GFCGHVAQTGQTI 65
Query: 404 NIPDAYSDYRFNRDVDEATGYKTISILCMPI---KVEGKVIGVVQMVNKRDDKYFGDDDE 460
N+ DA+ D RF++ +D Y+T S+LC PI K +V+GV+Q+ NK + +F DDE
Sbjct: 66 NVLDAHLDDRFDKQLDLKNNYRTKSVLCAPIFDTKSSNRVMGVLQVTNKLNQSFFTKDDE 125
Query: 461 AAFEIFS 467
++ +
Sbjct: 126 GILKVIA 132
>UniRef50_A5UXN7 Cluster: Sensor protein; n=5; Chloroflexi
(class)|Rep: Sensor protein - Roseiflexus sp. RS-1
Length = 819
Score = 73.7 bits (173), Expect = 2e-11
Identities = 46/176 (26%), Positives = 94/176 (53%), Gaps = 11/176 (6%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
L + K++ ++ L++L+ RI+E + A+ L L D +EL L+ L
Sbjct: 144 LYSIGKSV-SSLLDLEELLVRIVEAGVYITRAEEGFLLLRDLHANELY-----LRAAKNL 197
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK 435
+ +++RMPI+ +AG V +G+ + + A + + TG+ +IL +P+
Sbjct: 198 G-EQRAQKMRMPIDDSLAGQVIRTGKPIRLDKAGA----GAQLKVITGFLVRAILQVPLM 252
Query: 436 VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYR 491
V +VIGV+ + N++ ++ F D+D+ + + +A+ +ARLY+++ + E +YR
Sbjct: 253 VGNQVIGVLAVDNQQSERTFSDNDQYLLSALADYAAIAIENARLYEQVKQSEARYR 308
>UniRef50_Q3JEL0 Cluster: Protein phosphatase 2C-like, stage II
sporulation E; n=1; Nitrosococcus oceani ATCC 19707|Rep:
Protein phosphatase 2C-like, stage II sporulation E -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 423
Score = 73.3 bits (172), Expect = 3e-11
Identities = 59/199 (29%), Positives = 99/199 (49%), Gaps = 22/199 (11%)
Query: 327 MVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRM 386
+ L +L+ +I A ++ +RA++F+ D+ ++EL S V ++IR
Sbjct: 31 ITDLQKLLAQIEHAALKIFACERATVFVFDHDSNELYSYVAS-----------RPEKIRF 79
Query: 387 PINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKV-IGVVQ 445
P +GIAG + + + DAY D RFN VD+ T +KT +IL P+ + IGV+Q
Sbjct: 80 PARQGIAGECFHNNHIIKVSDAYKDPRFNPAVDDETKFKTHNILSCPLTTHDQTPIGVLQ 139
Query: 446 MVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCRE 505
++NK + F DE S G+AL L ++ + K+ R+ ++ N R
Sbjct: 140 ILNKCSGE-FNQWDEILLRTLSAQCGVALERQFLLEQFVEKQ---RLQHDI----NIAR- 190
Query: 506 YEVQAMLLDKEPLNVDFAD 524
++Q LL K+P V+ D
Sbjct: 191 -QIQQHLLPKQPPAVEGFD 208
>UniRef50_A0H3D2 Cluster: Sensor protein; n=4; Chloroflexaceae|Rep:
Sensor protein - Chloroflexus aggregans DSM 9485
Length = 726
Score = 73.3 bits (172), Expect = 3e-11
Identities = 45/187 (24%), Positives = 89/187 (47%), Gaps = 7/187 (3%)
Query: 304 VDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELV 363
+++ RN L+ + A M+ + ++E + + SL ++D ++V
Sbjct: 181 IEEAEYRNAELMTLNDIAAAVNSMLDPRDIYHLVMEKINQFFRVEAGSLLMLDEETGDMV 240
Query: 364 STVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATG 423
F + G + + + R+P GI G V + + + D D RF R+V E G
Sbjct: 241 ---FVITLAGGQEKLIGQ---RVPPGVGIVGDVVRTQQYAIVHDPERDPRFYRNVSEGIG 294
Query: 424 YKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
Y SILC+PI V+G+ IG ++++NKR + F +++ + G+A+ +A L+ ++
Sbjct: 295 YNVHSILCVPIVVKGRTIGAIELLNKRTGR-FTEEEALRLTRMAATIGIAIENAHLFQQV 353
Query: 484 MRKEQKY 490
++
Sbjct: 354 STVRDRF 360
>UniRef50_A2FCG2 Cluster: GAF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: GAF domain containing
protein - Trichomonas vaginalis G3
Length = 439
Score = 73.3 bits (172), Expect = 3e-11
Identities = 77/339 (22%), Positives = 145/339 (42%), Gaps = 32/339 (9%)
Query: 310 RNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDL 369
+N + LL++ ++ E L +++ I E A L+NA+R ++FL+D ++
Sbjct: 2 KNRVEGLLNLAMSMSREKY-LPLILEHISESAIELINAERCTVFLMDDDKEGIIHQT--- 57
Query: 370 KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
EK ++ + + + +L +NI D D R++ D+ T + + S
Sbjct: 58 ---------NEKTNAQIAFIKEVCKNKSL----LNISDVTKDSRYDPTEDQRTSFVSKSF 104
Query: 430 LCMPIKVEGK-VIGVVQMVNK---RDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMR 485
L PI E K ++GV+Q+VNK D F DDE ++F G ++ + D+ +
Sbjct: 105 LVAPIMDEEKNILGVIQIVNKIPGYDGLVFTKDDERLVGAMTSFAGYSISKVKNKDKNIT 164
Query: 486 KEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMF 545
+ + + + Q L +E + Y+ + + K + +I F
Sbjct: 165 TDAVFDLFSSSAEQIGVVLQ---QMRLSQEEETTLTNPQAYMRGLQMN--LKLRFMIFCF 219
Query: 546 R--DLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILK-SDVKERFDY 602
+L D T +F + + + +PYHN D +Y ILK ++V ++ D
Sbjct: 220 TSFNLLDQLNIQFITFFQFLMLFQTMGKDLPYHNSDQSLDTLQYVYVILKQTEVSKQLD- 278
Query: 603 NKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY 641
AL +A L H+ +H+G + T PL ++
Sbjct: 279 --TIELFALLMASLLHNTNHKGEHGGLLIRTKLPLEILF 315
>UniRef50_A2DCH1 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1106
Score = 72.9 bits (171), Expect = 4e-11
Identities = 68/309 (22%), Positives = 132/309 (42%), Gaps = 19/309 (6%)
Query: 514 DKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRD--LFDMTQFDITTLTRFTLTVKKNYR 571
D +DF D +F++ E + L +I F + +N
Sbjct: 811 DSLKTGIDFLSEDFDSSQFNQRELAIAVAEFIEKDGLSKALNINIGLFIEFVREILQNCN 870
Query: 572 TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMS 631
+H++ H V + KS + RL+L++A + HD H G+ N +
Sbjct: 871 AT-FHDYHHSIDVLTQCIQMCKSSYGQVL---LPIERLSLYIAAISHDSLHDGFVNLKLG 926
Query: 632 ETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYK-EILGFIRHCILATDL 690
+P + S +E +V L+Q F ++ +D K E+L ILATD+
Sbjct: 927 ---TPYECLLKFSPMEMR----SVDFLRQSVEK-FEFLTEKDAKNELLSEASRFILATDM 978
Query: 691 AAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIF 750
+ F +++ ++L SD FS++D R I + +ADL ++ + + K K +
Sbjct: 979 SKHFDLIEEAKKLADSDN--FSFEDKETRMKTTEILIKSADLGSANRNGDKADK--KGLP 1034
Query: 751 EEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYA 810
+EF+ +GD + + + K S++ F++ + +P ++ L +LP+ + M
Sbjct: 1035 DEFFAEGDLSKVKDIVYDKEGNERKNIHWGDSEIPFMNDVLVPTFETLAMLLPDLEDMLK 1094
Query: 811 MATKNLNRW 819
+N+ +W
Sbjct: 1095 QVKENVEKW 1103
>UniRef50_A0D3N1 Cluster: Chromosome undetermined scaffold_36, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_36,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 429
Score = 72.9 bits (171), Expect = 4e-11
Identities = 71/310 (22%), Positives = 127/310 (40%), Gaps = 23/310 (7%)
Query: 536 EKCKCIISMFRDLFDMTQF-DITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAIL-K 593
E K + +F+ L ++ QF + L + NY V YHNF H + + ++ + K
Sbjct: 122 EMLKASMMIFQHL-EVEQFANYNNLENLLTHINLNYNIVSYHNFTHAFALFQLLFCVYEK 180
Query: 594 SDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAA-MYTTSTLEHHHFN 652
SD+K + A +A L HD++H+G N Y + + L + + LE H +
Sbjct: 181 SDLKL---FVSKQDIFAALLASLSHDINHKGVNNLYKVKKSKKLNKNICEQAVLESMHVS 237
Query: 653 ITVTILQQDGH-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNL----DKIRELYRSD 707
IL Q+ N +++ + +E + ILATD+ F D++
Sbjct: 238 TLFNILAQNQQLNFLNYLPNAQQQEFKRILVSSILATDMGQHFNIFSCFKDRVNATIELR 297
Query: 708 EAQ-----------FSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQ 756
E+Q F+ ++ R + + + A D+S W+ +K ++ +EF DQ
Sbjct: 298 ESQDITDPLIRYRGFNKENFDDRKFILNVLVHACDISNPCLEWDAYMKWSFLLAQEFQDQ 357
Query: 757 GDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNL 816
KE A G M+ Q FL+ +P + + + P+ + +NL
Sbjct: 358 TIKEAAKGLEVTAMLQYKDKLTFFNGQTFFLNTFVLPQWQTIATLYPSLIELPNEVKRNL 417
Query: 817 NRWKARADKI 826
+ KI
Sbjct: 418 EILEEEKKKI 427
>UniRef50_Q8DLK6 Cluster: Tlr0485 protein; n=3; Cyanobacteria|Rep:
Tlr0485 protein - Synechococcus elongatus
(Thermosynechococcus elongatus)
Length = 537
Score = 72.1 bits (169), Expect = 6e-11
Identities = 41/129 (31%), Positives = 77/129 (59%), Gaps = 10/129 (7%)
Query: 329 SLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPI 388
SL++L+ IL ++++ +D ++FLV + L F + L + ++ +P+
Sbjct: 34 SLEELLHLILTKSRQITASDAGTIFLVQRERAVLE---FKAAQNDSVTLPEQVQDYTIPL 90
Query: 389 NR-GIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYKTISILCMPIK-VEGKVI 441
+ G+ AL+GE++NI D Y+ Y+FNR DEA Y+T S+L +P++ + G+VI
Sbjct: 91 TADSLVGYAALTGESLNIADVYALKGSEMYQFNRSFDEALHYRTCSVLVVPMQNISGEVI 150
Query: 442 GVVQMVNKR 450
GV+Q++N++
Sbjct: 151 GVLQLINRK 159
>UniRef50_A3ZU96 Cluster: Probable two-component response regulator;
n=1; Blastopirellula marina DSM 3645|Rep: Probable
two-component response regulator - Blastopirellula
marina DSM 3645
Length = 651
Score = 72.1 bits (169), Expect = 6e-11
Identities = 46/175 (26%), Positives = 90/175 (51%), Gaps = 13/175 (7%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGL 375
LL ++++ +++ + L+ + E A L ++RAS+FL D LV P L
Sbjct: 163 LLTIIES-WQKTRDMHTLLTEMAEAAAELFGSERASIFLWDRPKKTLVG-------RPAL 214
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMP-I 434
+ E E+R+P +RG+ GHV +GE + + D NRD+D++ + T ++LC+P +
Sbjct: 215 GI--EGGELRVPDDRGVVGHVVQTGEPRRVDELDKD-EINRDIDQSLAFHTRNLLCVPLV 271
Query: 435 KVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
G++ G +++NK+ + +D E+ + AL + + +RI+ +
Sbjct: 272 GRRGRIFGAFELINKQLGNFTAEDQLGLTEL-AAHASSALENTQETERILASRNR 325
>UniRef50_A6R1R4 Cluster: Predicted protein; n=1; Ajellomyces
capsulatus NAm1|Rep: Predicted protein - Ajellomyces
capsulatus NAm1
Length = 839
Score = 72.1 bits (169), Expect = 6e-11
Identities = 69/280 (24%), Positives = 111/280 (39%), Gaps = 22/280 (7%)
Query: 618 HDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKE 676
HD+ H G N ++ +PLA +Y TS LE H +L+ + + +
Sbjct: 299 HDVGHPGVNNVFLVRLNAPLAQLYNDTSVLESFHCAAYSQLLRSYWPSFVMDM------K 352
Query: 677 ILGFIRHCILATDLAA---FFPNLDKIRELYRSDEAQFSWDD---PSHRDLAMAISMTAA 730
+ + ILATD+ F +L K+RE Y + W D ++R L + M A
Sbjct: 353 LRKLMISSILATDMGVHFKFMESLGKLREKYHETHSTDRWTDNEIETNRALLCGLLMKCA 412
Query: 731 DLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI----PMMDRNKPEEQPASQVGF 786
D+S A+ W+I + V+ EEF QG+ E+ G P N P + SQ+ F
Sbjct: 413 DISNVARTWDIAKRWTNVLQEEFAQQGNMEKTIGMETALFGGPPELGNVP-KLAKSQINF 471
Query: 787 LSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKILFKQXXXXXXXXXXLEPKXX 846
+ +P ++ L +LP+ +N + W+ ++ + + P
Sbjct: 472 IKLFALPLFENLAYLLPDMAFTTVEIRRNKSIWREIINREVQSRMSLELIQSSTTTPLAQ 531
Query: 847 XXXXXXXVTVKNEGNKRVEIIRQESKTIIGEAQPKPVVWN 886
VKNE + ES I P P WN
Sbjct: 532 SDSHLPSSDVKNEDFGETPL--DESAVNIHRVLPGP--WN 567
>UniRef50_Q4FPK0 Cluster: Sigma factor sigB regulation protein; n=2;
Candidatus Pelagibacter ubique|Rep: Sigma factor sigB
regulation protein - Pelagibacter ubique
Length = 448
Score = 71.3 bits (167), Expect = 1e-10
Identities = 54/213 (25%), Positives = 102/213 (47%), Gaps = 19/213 (8%)
Query: 324 FEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKE 383
F + + L + ++ LE + +NA A++FL+D N + K + L+ +
Sbjct: 53 FAKTLDLKETLQTSLELIIKRINAQAANIFLID--NDKQNFQCIASKHQAYLE------D 104
Query: 384 IRMPINRGIAGHVALSGETMNIPDAYSDYR----FNRDVDEATGYKTISILCMPIKVEGK 439
+PI +G+ G AL + + + D D R F D+D T + T S+LC P+ V +
Sbjct: 105 FEIPITQGVMGKAALMKQCIRVGDVRKDVREIAEFYFDLDNKTNFTTYSVLCSPLIVSDE 164
Query: 440 VIGVVQMVNKR-DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIM---RKEQKYRVALE 495
IGV+ +NK+ D+K F + D E S LA+ +A++ ++ R E++ + E
Sbjct: 165 CIGVIHCLNKKTDNKLFEESDRKLLETLSGPAALAIRNAKMAKDLIVKNRIEKEIEIVGE 224
Query: 496 V---LSYHNTCREYEVQAMLLDKEPLNVDFADF 525
+ L N + + + + + ++ DF +F
Sbjct: 225 IQKTLLSQNIKENFPIAGINIPAKVVSGDFYNF 257
>UniRef50_Q31L46 Cluster: Metal dependent phosphohydrolase; n=2;
Synechococcus elongatus|Rep: Metal dependent
phosphohydrolase - Synechococcus sp. (strain PCC 7942)
(Anacystis nidulans R2)
Length = 560
Score = 70.9 bits (166), Expect = 1e-10
Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 8/127 (6%)
Query: 331 DQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINR 390
DQL+ IL+ ++ L +D SL+LVD + + F + L +E +P++R
Sbjct: 42 DQLLSLILQSSRDLTCSDGGSLYLVDRSDPQQPWLRFQIFQSDSLPSSLEAPP-PLPLDR 100
Query: 391 -GIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYKTISILCMPI-KVEGKVIGV 443
+AG+VA +GET+N+ D Y+ ++FN D+ Y+T S+L +P+ G VIGV
Sbjct: 101 HSLAGYVAATGETLNLADVYALDGQQPFQFNASFDQRLNYRTCSMLVLPMCDQTGSVIGV 160
Query: 444 VQMVNKR 450
+Q+VN++
Sbjct: 161 IQLVNRK 167
>UniRef50_A0W5M8 Cluster: Metal dependent phosphohydrolase; n=2;
Geobacter|Rep: Metal dependent phosphohydrolase -
Geobacter lovleyi SZ
Length = 373
Score = 70.5 bits (165), Expect = 2e-10
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 9/157 (5%)
Query: 329 SLDQL-IKRI-LEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRM 386
SLD ++R+ +E R V AD ASL L+D EL E G L KE+R+
Sbjct: 29 SLDPAEVRRLAVEAVPRCVGADAASLLLLDGATGELYFEA--ASGEKGRHL----KEVRL 82
Query: 387 PINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQM 446
GIAG VA G + + D D RF D+D TGY T +++ P+ + KV GV+Q+
Sbjct: 83 KPGEGIAGWVARKGGAVIVDDVKHDPRFASDIDRFTGYDTRNMIVAPVATKEKVWGVLQV 142
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
+NK + D E + + +A+ +A +Y +
Sbjct: 143 LNKVTGDFNAHDLELV-QALADQVAIAIENASMYQEM 178
>UniRef50_UPI000065D378 Cluster: cAMP-specific 3',5'-cyclic
phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).;
n=4; Euteleostomi|Rep: cAMP-specific 3',5'-cyclic
phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46). -
Takifugu rubripes
Length = 715
Score = 70.1 bits (164), Expect = 3e-10
Identities = 39/134 (29%), Positives = 67/134 (50%), Gaps = 4/134 (2%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + T + +T++ +Y V YHN H V + + +L + + +
Sbjct: 371 RDLLKTFRIPVDTFVTYVMTLEDHYHANVAYHNSLHAADVTQSTHVLLSTPALDAV-FTD 429
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
ALF A + HD+DH G +N+++ T S LA MY S LE+HH + +L +D
Sbjct: 430 LEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHEDNC 488
Query: 664 NIFSHISSEDYKEI 677
+IF ++S + +
Sbjct: 489 DIFQNLSKRQRQSL 502
Score = 50.0 bits (114), Expect = 3e-04
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 685 ILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHRDLAMAISMTAADLSASAKPWE 740
+LATD++ L ++ + + + S D + R + + ADLS KP
Sbjct: 538 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDHYTDRIQVLRNLVHCADLSNPTKPLA 597
Query: 741 IQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYD 796
+ + + I EEF+ QGDKER G PM D++ + SQVGF+ I P ++
Sbjct: 598 VYRQWTERIMEEFFRQGDKERERGMEISPMCDKHTASVE-KSQVGFIDYIVHPLWE 652
>UniRef50_Q2WAI7 Cluster: Serine phosphatase RsbU; n=3;
Magnetospirillum|Rep: Serine phosphatase RsbU -
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length = 555
Score = 70.1 bits (164), Expect = 3e-10
Identities = 52/175 (29%), Positives = 80/175 (45%), Gaps = 9/175 (5%)
Query: 324 FEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKE 383
F ++ ++ LE + V A ASLFL+D +LV P ++
Sbjct: 24 FAHSQDVEATLRLGLERIAQRVGAQAASLFLIDDDTGDLVCRA---NVGP-----VDVVG 75
Query: 384 IRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGV 443
+R+P GI G G + D D F + +D ATG++T SILC P+ V G +G
Sbjct: 76 LRLPPGTGIVGRTIDLGAPQLVKDTRRDPDFAQAIDAATGFETRSILCAPMMVRGTRLGA 135
Query: 444 VQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS 498
+++ NK D F D + + LAL +ARL M ++Q + LE+ S
Sbjct: 136 IELFNKTDGNAFSLTDSRLLQALAASSALALINARLV-ADMAEQQSLKRELELAS 189
>UniRef50_A0W4L6 Cluster: Metal dependent phosphohydrolase; n=2;
Geobacter|Rep: Metal dependent phosphohydrolase -
Geobacter lovleyi SZ
Length = 415
Score = 69.3 bits (162), Expect = 4e-10
Identities = 50/176 (28%), Positives = 86/176 (48%), Gaps = 22/176 (12%)
Query: 326 EMVSLDQLIKRILEFAQRLVNADRASLFLVD-------YRNSELVSTVFDLKFEPGLDLD 378
++ +D L+++IL A+R D ++++ D Y ++ V+T + P
Sbjct: 20 QIKDIDFLLEKILSEARRFTGCDAGTIYIKDGNWLAARYSQNDTVNT----QLAPHRKSV 75
Query: 379 MEKKEIRMPINRGIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYKTISILCMP 433
IR+ N IAG+VA +G +NIPD Y Y FNR D+ T Y+T S L +P
Sbjct: 76 YSNITIRVD-NTSIAGYVAATGNQLNIPDVYHLDAGLPYSFNRSFDDLTNYRTTSQLVLP 134
Query: 434 I-KVEGKVIGVVQMVNKRDD----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIM 484
+ + G+ +GV+Q++N +D F +DE F+ A+ A++ I+
Sbjct: 135 LTSMRGETVGVLQLINAKDATGQVTSFDGNDENGISYFAVTAANAIERAKMTREII 190
>UniRef50_Q8EZC6 Cluster: GGDEF domain protein; n=4; Leptospira|Rep:
GGDEF domain protein - Leptospira interrogans
Length = 327
Score = 68.5 bits (160), Expect = 8e-10
Identities = 31/101 (30%), Positives = 59/101 (58%)
Query: 382 KEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVI 441
+ IR+ GIAG V + + + + +D RF++ VDE TG++T +I+ +P+ G+V
Sbjct: 73 RSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVH 132
Query: 442 GVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR 482
GV+++VN+ D F +D + + F ++L H+ Y++
Sbjct: 133 GVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEK 173
>UniRef50_A0EF18 Cluster: Chromosome undetermined scaffold_92, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_92,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 929
Score = 68.5 bits (160), Expect = 8e-10
Identities = 69/305 (22%), Positives = 131/305 (42%), Gaps = 28/305 (9%)
Query: 507 EVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFR--DLFDMTQFDITTLTRFTL 564
E +A+ +D+ +D DF + + EK + + + + ++ + D L F
Sbjct: 615 EKEAICIDQ----IDSFDFNIFKIENNSIEKQRIVYQILNRNNFIEIFEIDKNRLCEFLG 670
Query: 565 TVKKNY--RTVPYHNFDHGWTVAHAMYAILKSDVKERFDYN---KASSRLALFVACLCHD 619
++ Y R P+HN++HG V H+ + I+ + + Y ++L+L ++ LCHD
Sbjct: 671 ELEYRYDKRRNPFHNYNHGVNVMHSCHVIMNKMINQP-QYKVLFDQLTKLSLILSGLCHD 729
Query: 620 LDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
+ H G TN + S A Y + LE +H + +L ++ N ++ ++E
Sbjct: 730 VGHTGRTNIFEINNFSEKAIRYHDKNVLEQYHAATALKLLLKERMNFLKNVDFRQFRE-- 787
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
FI++ I+ TD F NL K E + + + + + +D + ++
Sbjct: 788 KFIQN-IIFTDKQEHF-NLLKFFEANNEKDIK----------IITGMIIHTSDFAGASAK 835
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMM-DRNKPEEQPASQVGFLSQICIPCYDM 797
W I + + +EF Q ++E G P M D K S++GF P Y
Sbjct: 836 WPISKQWSLRVNQEFQAQFEEEGRLGLPQQPFMKDLQKISVLSKSEIGFYKFFVRPLYVS 895
Query: 798 LYRIL 802
L + +
Sbjct: 896 LSKFM 900
>UniRef50_Q2JV17 Cluster: GAF domain protein; n=2;
Synechococcus|Rep: GAF domain protein - Synechococcus
sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 406
Score = 68.1 bits (159), Expect = 1e-09
Identities = 50/150 (33%), Positives = 87/150 (58%), Gaps = 19/150 (12%)
Query: 312 MSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKF 371
+S L+ V A+ E L +L++ I+ A+ L D ASLF+ R E +L+F
Sbjct: 25 LSQRLIQVGIALSSE-TDLRRLLELIVAQARELTCCDGASLFI---REGE------ELRF 74
Query: 372 EPGLDLDMEKKEIRMPIN-RGIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYK 425
++ + E +++R+P+ I G+V L+GE++N+PD Y Y FN VD+ TGY+
Sbjct: 75 FV-VNRNEELQDLRLPLAPSSIVGYVVLTGESLNLPDVYRLPAGLPYAFNSQVDQQTGYR 133
Query: 426 TISILCMPIK-VEGKVIGVVQMVNK-RDDK 453
T S+L +P++ G ++G +Q++N+ R D+
Sbjct: 134 TRSLLTVPMRDPSGNILGALQLLNRLRPDR 163
>UniRef50_Q025X3 Cluster: Serine phosphatase; n=1; Solibacter
usitatus Ellin6076|Rep: Serine phosphatase - Solibacter
usitatus (strain Ellin6076)
Length = 581
Score = 68.1 bits (159), Expect = 1e-09
Identities = 52/238 (21%), Positives = 114/238 (47%), Gaps = 15/238 (6%)
Query: 259 ITKSGKTSYVLEMWRTK-DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLL 317
+T GK V+++ T+ D + D + I S+A+ +LY R+ L
Sbjct: 127 MTARGKLVGVIDLQSTRVDAYTEYDRALMRLIAARVSIAIDNARLYRRADRQNRTLKTLA 186
Query: 318 DVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDL 377
++ + F ++ L++L+ +I L+ D S+ VD+ ++ + +F ++++ +++
Sbjct: 187 NISRE-FSSILDLNELLSKIASTMHDLIAYDAFSILSVDHE-AKALKHLFSIRYDKRVNI 244
Query: 378 DMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE 437
D +P+ +G+ G A S E + + D D R+ A+ S + +P+ ++
Sbjct: 245 D------NVPLGKGLTGAAAESREVVRVHDTAKDPRYI-----ASHADIRSEVAVPLILQ 293
Query: 438 GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALE 495
+V+GV+ + + R YF DD + + ++ +ARLY + ++E++ LE
Sbjct: 294 DRVVGVMDLESDRVG-YFNDDQVRTLALLAPQVASSVENARLYAELAQRERRMEQDLE 350
Score = 63.3 bits (147), Expect = 3e-08
Identities = 61/229 (26%), Positives = 107/229 (46%), Gaps = 23/229 (10%)
Query: 308 RERN-MSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTV 366
RER+ + DFLL+V +I + + LDQL+ + E Q+++ D ++ L R +L
Sbjct: 12 RERSELLDFLLEVSASITQTL-DLDQLLANVAEMVQKVLPYDLFAILLYSERRRDL---- 66
Query: 367 FDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
+++ G D + + + GI G A E + + D +D R+ VD
Sbjct: 67 -RIRYAVG-HRDDVVRNLSIAEGEGITGTAAARREPVLVSDVRNDPRYLNTVDAVR---- 120
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRK 486
+ L +P+ GK++GV+ + + R D Y + D A + + +A+ +ARLY R R+
Sbjct: 121 -TELAVPMTARGKLVGVIDLQSTRVDAY-TEYDRALMRLIAARVSIAIDNARLYRRADRQ 178
Query: 487 EQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEF 535
+ L+ L+ N RE+ + +LD L A D +D F
Sbjct: 179 NR----TLKTLA--NISREF---SSILDLNELLSKIASTMHDLIAYDAF 218
>UniRef50_A6S8A0 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 945
Score = 68.1 bits (159), Expect = 1e-09
Identities = 69/292 (23%), Positives = 125/292 (42%), Gaps = 35/292 (11%)
Query: 559 LTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKS--------DVKERFDYNKAS--- 606
LT F +T ++ Y + VPYHNF H V A++ L + K+S
Sbjct: 361 LTAFLITSREAYNSFVPYHNFRHVVDVLQAIFHFLVRLGSLPEYPPSPDGTTSQKSSPIA 420
Query: 607 ------SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQ 659
L L + + HD+ H G N ++ +PLA +Y S LE H IL+
Sbjct: 421 ELIRPFDALTLMITAIGHDVGHPGVNNAFLVHLNAPLAQLYNDRSVLESFHCAAYSQILR 480
Query: 660 QDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKI----RELYRSDEAQFSWDD 715
+ +++ + +++ + ILATD+ F + K+ +L+ + W+
Sbjct: 481 R------HWLAAFEERDMRHLMISTILATDMGLHFDYMKKLGYLQEKLHENGGVTDGWNG 534
Query: 716 ---PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
R LA ++ + AD+S A+ ++ + +++ +EF Q E+ G IP +
Sbjct: 535 RTIEDQRTLACSLLIKCADISNVARKFDTATRWTEILTDEFARQASMEQDLG-IPTALYA 593
Query: 773 RNKPE--EQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKAR 822
E E SQ+GF++ IP + + ++P +N W++R
Sbjct: 594 APVREVIELGKSQIGFMNMFAIPLFGGVTDVMPGMAFCVEELERNKAAWESR 645
>UniRef50_Q7QRM3 Cluster: GLP_481_5888_1773; n=1; Giardia lamblia ATCC
50803|Rep: GLP_481_5888_1773 - Giardia lamblia ATCC 50803
Length = 1371
Score = 67.7 bits (158), Expect = 1e-09
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 17/195 (8%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFS 667
LAL LCHDL H G N + T + LA +Y + LEH H ++ I+ Q F
Sbjct: 1134 LALLFGSLCHDLGHTGIDNLFCINTENALALLYNDEAPLEHAHATLSWHIITQMA-VYFK 1192
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMA--- 724
H + Y+E ILATD++ F L ++ L DE H D +A
Sbjct: 1193 HFTPCQYREFRALFLEIILATDMSTHFNFLRRLESL---DEDLIIKILEHHNDSEIALLR 1249
Query: 725 -----ISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDR-NKPEE 778
+ + DLS +P EI + + EF+ GD G P + R K EE
Sbjct: 1250 WYILKVCIKFGDLSNPCRPIEISTRYAVALMNEFWSLGDLMLECGLEPDKIKTRPQKGEE 1309
Query: 779 Q---PASQVGFLSQI 790
SQ+GF I
Sbjct: 1310 SLIIANSQIGFTQSI 1324
>UniRef50_Q1D911 Cluster: GAF/GGDEF domain protein; n=3;
Cystobacterineae|Rep: GAF/GGDEF domain protein -
Myxococcus xanthus (strain DK 1622)
Length = 364
Score = 67.3 bits (157), Expect = 2e-09
Identities = 51/199 (25%), Positives = 92/199 (46%), Gaps = 15/199 (7%)
Query: 318 DVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDL 377
++ KA+ + L +++ +++ L+ SL L D R +L F++ G D+
Sbjct: 22 EMAKALTSTL-ELREVLALVMQKVSSLLLPRNWSLILQDERTGKLY---FEIAVGDGADV 77
Query: 378 DMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE 437
K +++ GIAG V SG + D D F+ DEA+ + T SIL +P+
Sbjct: 78 ---LKGLQLNPGEGIAGAVFTSGAARLVHDVGGDPSFSPRFDEASAFHTRSILAVPLLAR 134
Query: 438 GKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVL 497
G+V+G++++VN D F ++D + + +A+ +AR + R+ L +
Sbjct: 135 GRVLGIIELVNGPMDPPFTNEDLTILTAIADYAAIAIENARNFRRVQE--------LTIT 186
Query: 498 SYHNTCREYEVQAMLLDKE 516
H C LLD+E
Sbjct: 187 DEHTGCYNARHLRALLDQE 205
>UniRef50_UPI000065CC62 Cluster: cGMP-inhibited 3',5'-cyclic
phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited
phosphodiesterase A) (CGI-PDE A).; n=1; Takifugu
rubripes|Rep: cGMP-inhibited 3',5'-cyclic
phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited
phosphodiesterase A) (CGI-PDE A). - Takifugu rubripes
Length = 706
Score = 65.7 bits (153), Expect = 5e-09
Identities = 62/221 (28%), Positives = 98/221 (44%), Gaps = 38/221 (17%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T++P A +Y S LE+HH + + +N
Sbjct: 388 MALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSHPEYNFL 447
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQFS-W- 713
++ ++K + ILATDL F L + ++ Y+ A + W
Sbjct: 448 VNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKVMIKNRILKRTYKRSLADLARWL 507
Query: 714 -----------DDPS---------HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEF 753
DDPS R L + + AD++ K ++ ++ + I EF
Sbjct: 508 HHVCLPVHQVGDDPSTGIDWSNENDRLLVCQMCIKLADVNGPLKCKDLHLQWTEGIVNEF 567
Query: 754 YDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
Y QGD+E + G +PI P MDR P + Q F++ I P
Sbjct: 568 YQQGDEESSMG-LPISPFMDRAAP-QLAKLQESFITHIVGP 606
>UniRef50_Q6MLW2 Cluster: NtrC family transcriptional regulator;
n=1; Bdellovibrio bacteriovorus|Rep: NtrC family
transcriptional regulator - Bdellovibrio bacteriovorus
Length = 530
Score = 65.3 bits (152), Expect = 7e-09
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 14/208 (6%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVF 367
+ + F+ D + FE+ + LI RIL+ + ADR ++F N E
Sbjct: 22 KSHELLKFIGDSAQIFFEQQAG-ESLISRILDLCIQATGADRGTIFFDSQINLEQHFKYL 80
Query: 368 DLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTI 427
+ G+ + I + ++GIAG V + ++ D F VD TGY+T
Sbjct: 81 NSYIATGI----RNQTIVINTDQGIAGKVFRTRKSYFSNCVAQDKDFYLGVDSKTGYQTE 136
Query: 428 SILCMPIK-VEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDR---- 482
+L +P+ +GKVIGV++++NK D F + D+ A E S +A + ++ +
Sbjct: 137 KVLAVPLHWKDGKVIGVIEVLNKADGD-FDETDQHALEALSMLAAVAFENYEVHQKNEES 195
Query: 483 ---IMRKEQKYRVALEVLSYHNTCREYE 507
I ++ +R ++ +S H+ E +
Sbjct: 196 ESAIEHRKNIWRKSISSVSLHSKAPELQ 223
>UniRef50_Q2LSR2 Cluster: HD-GYP domain protein; n=1; Syntrophus
aciditrophicus SB|Rep: HD-GYP domain protein -
Syntrophus aciditrophicus (strain SB)
Length = 540
Score = 65.3 bits (152), Expect = 7e-09
Identities = 52/162 (32%), Positives = 86/162 (53%), Gaps = 18/162 (11%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR----NS 360
+K+ RN L+++ A+ E +LD+L ++ILE A+ L NAD +L+LV N
Sbjct: 17 EKQLTRNKR--LVEIGIALTTEK-NLDRLFEKILEEARELTNADAGTLYLVSDEEPLLNF 73
Query: 361 ELVSTVFDLKFEPGLDLDMEKKEIRM------PINRGIAGHVALSGETMNIPDAYSDYRF 414
L+ + G + +R+ P ++ + ALSGE +NIPD Y+ F
Sbjct: 74 ALIQNDTLGIYMGGTGAKISWPPVRLRNDDDTPNYANVSAYAALSGEVVNIPDVYNAEGF 133
Query: 415 N----RDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNKRD 451
N R D TGY++ S+L +P++ E +IGV+Q++N +D
Sbjct: 134 NFEGTRHYDIETGYRSKSMLVIPMRNHENDIIGVLQLLNAKD 175
>UniRef50_Q2IFQ3 Cluster: Putative GAF sensor protein; n=1;
Anaeromyxobacter dehalogenans 2CP-C|Rep: Putative GAF
sensor protein - Anaeromyxobacter dehalogenans (strain
2CP-C)
Length = 306
Score = 65.3 bits (152), Expect = 7e-09
Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 337 ILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHV 396
+LE A + S+FL+ EL F + P D + ++ +R+P+ G+ G
Sbjct: 172 LLELALERTGCEAGSVFLLRPGERELS---FAVARGPAADAIL-RRGVRVPVGAGVVGFC 227
Query: 397 ALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFG 456
+ + D D RF+ V A GY+ S+LC PI G+V+G ++++NKR + F
Sbjct: 228 VQENVALAVSDVRQDPRFDDAVARAAGYEARSLLCTPIARGGRVLGAIEVMNKRGGELFD 287
Query: 457 DDDEAAFEIFS 467
D A + +
Sbjct: 288 QQDVAVLALLA 298
>UniRef50_Q0LJE8 Cluster: Sensor protein; n=1; Herpetosiphon
aurantiacus ATCC 23779|Rep: Sensor protein -
Herpetosiphon aurantiacus ATCC 23779
Length = 1211
Score = 65.3 bits (152), Expect = 7e-09
Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 7/180 (3%)
Query: 301 KLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS 360
+LY R+ + L ++ + I + + + I+ Q L+N + SL L+D +
Sbjct: 309 RLYERTTRQARQLELLNELGRTITSTL-DFEAVPSLIMGRVQELLNVEEGSLLLLDEATN 367
Query: 361 ELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDE 420
ELV F P + + R+P N GIAG V +GE++ A F +D
Sbjct: 368 ELV---FRYSLSP---VGQQLLGNRIPSNVGIAGLVLRTGESLIANRAGDHPAFYTGIDM 421
Query: 421 ATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
G++T +LC+P+ G V GV++++N R+ F D A E + +A+ ++ LY
Sbjct: 422 LVGHETRDLLCVPLLGAGGVKGVIEILNHRNGLPFTAADRALLEAVADQAVIAIENSNLY 481
>UniRef50_A1HLR9 Cluster: Diguanylate cyclase/phosphodiesterase with
GAF sensor precursor; n=1; Thermosinus carboxydivorans
Nor1|Rep: Diguanylate cyclase/phosphodiesterase with GAF
sensor precursor - Thermosinus carboxydivorans Nor1
Length = 728
Score = 64.9 bits (151), Expect = 1e-08
Identities = 54/196 (27%), Positives = 92/196 (46%), Gaps = 9/196 (4%)
Query: 305 DKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVS 364
+K RE+N +L V L L++ +LE A +LV A +F+VD L+
Sbjct: 115 EKLREQNAYLKMLYEVTLSINRQADLAGLLRTVLEKAGQLVGTQHACIFMVDQAADRLI- 173
Query: 365 TVFDLKFEPGLDLDMEKK-EIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATG 423
LKF G ++ + +I + G+AG +G T+++ D Y + +R T
Sbjct: 174 ----LKFAIGYYQEVSRDYQIALARGEGLAGRAWQTGNTVSV-DNYETW-LHRVTSLPTA 227
Query: 424 YKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRI 483
++ +P+KV +VIGV+ ++ F D E F+ LALH+A LYD++
Sbjct: 228 QMG-AMAAIPLKVNDRVIGVLNVLYLDSQMAFTPDKIDLLERFANLAALALHNAGLYDKL 286
Query: 484 MRKEQKYRVALEVLSY 499
+ + R A E ++
Sbjct: 287 RVELAQRRQAEEKATF 302
>UniRef50_Q6CHK1 Cluster: Similar to tr|Q8NJP9 Candida albicans High
affinity cAMP phosphodiesterase; n=1; Yarrowia
lipolytica|Rep: Similar to tr|Q8NJP9 Candida albicans
High affinity cAMP phosphodiesterase - Yarrowia
lipolytica (Candida lipolytica)
Length = 626
Score = 64.9 bits (151), Expect = 1e-08
Identities = 82/342 (23%), Positives = 138/342 (40%), Gaps = 42/342 (12%)
Query: 514 DKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMT-----QFDITTLTRFTLTVKK 568
D E AD+ DPF E + MF+ + + + + L RF + ++
Sbjct: 292 DLEAARERIADWDYDPFELSYDELVIMALVMFQYILSLPGLEPYRLEEPELVRFLIMMRD 351
Query: 569 NYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKA----------------SSRLA 610
Y PYHNF H V A + L + + +A + L
Sbjct: 352 AYHHENPYHNFRHAIDVMQATFQFLIRLGCLPPPPFKRAPNCSMIPPIGPAVFTPAESLV 411
Query: 611 LFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHI 669
+ +A + HD+ H G TN ++ + SP+A ++ S LE +H + +L NIF
Sbjct: 412 VIIAAIGHDISHPGVTNAFLVSSHSPMAQVFNDKSVLESYHACVLNRVL-----NIFWPA 466
Query: 670 SSEDYKEILGFIRHCILATDLAAFFPNLDKIRELY---------RSDEAQFSWDDPSHRD 720
+ E + + L I +LATD+A F +D+ EL R +E + + P+ R
Sbjct: 467 TQEPHLKKL--IVESVLATDMAQHFNYVDRWNELSARCRSKGKGRCNEERGNL-SPADRQ 523
Query: 721 LAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQP 780
L ++ M AD+S + ++ K +V+ EF + D E +P + K
Sbjct: 524 LVGSMIMKCADVSNVTRRLDLAEKWGRVLQCEFSEVKDVETDCNVQTLP-PNCGKNANLA 582
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKAR 822
SQV FL+ P + P + +N W++R
Sbjct: 583 QSQVSFLNIFAYPLFQQFSDAFPEFGYAFKTLQENKAVWESR 624
>UniRef50_A2FET3 Cluster: 3'5'-cyclic nucleotide phosphodiesterase
family protein; n=1; Trichomonas vaginalis G3|Rep:
3'5'-cyclic nucleotide phosphodiesterase family protein -
Trichomonas vaginalis G3
Length = 1135
Score = 64.1 bits (149), Expect = 2e-08
Identities = 56/264 (21%), Positives = 111/264 (42%), Gaps = 12/264 (4%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCH 618
+ +F V K Y+ YHN++H Y+I+K N + AL +ACL H
Sbjct: 875 IVKFLEEVSKLYKNNKYHNWNHAVETVQLCYSIVKRGKMSPRAINPMQTT-ALILACLLH 933
Query: 619 DLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEI 677
D+ H G +N+Y + S L ++ LE+ +V +L+ F I++E E
Sbjct: 934 DICHDGTSNEYHIKAKSSLYHVFGDDCPLENSSLTRSVRLLK--SQPFFVCINNE---EF 988
Query: 678 LGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAK 737
F + C+LATD+ + + ++ R+ F + H + +T A++S +
Sbjct: 989 WLFFKECLLATDIKKYEETIQNYQQCARN----FDSKNLIHSVSLAKLVITVANISNVVR 1044
Query: 738 PWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQPASQVGFLSQICIPCYD 796
P+ + + + E + +K R G + + + + +E P ++ F+ ++ P
Sbjct: 1045 PFSQAQQVAENLETETDETNEKLRTLGIKEQTFVYWKCESDELPNIEMKFIQEVATPLIK 1104
Query: 797 MLYRILPNTKPMYAMATKNLNRWK 820
+ P + + W+
Sbjct: 1105 AITGSFPELNDLNTSLEETKRNWQ 1128
>UniRef50_Q2H9G5 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 894
Score = 64.1 bits (149), Expect = 2e-08
Identities = 79/308 (25%), Positives = 125/308 (40%), Gaps = 46/308 (14%)
Query: 532 FDEFEKCKCIISMFRDLFDMTQFD---ITT--LTRFTLTVKKNYRT-VPYHNFDHGWTVA 585
F E E + MF+ M + + I T L RF L + Y T VPYHNF H V
Sbjct: 292 FTEDELVVAALVMFKHALSMPELEPWRIPTDRLHRFLLACRAAYNTFVPYHNFRHVVDVL 351
Query: 586 HAMYAIL---------------------KSDVKERFDYNKASSRLALFVACLCHDLDHRG 624
A + L KS + E + L L + + HD+ H G
Sbjct: 352 QATFHFLVRIGALPPYRSADGLLSAACRKSPIAELL---RPFEALTLLITAIGHDVGHPG 408
Query: 625 YTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRH 683
N ++ +PLA +Y S LE H IL++ F D ++ +
Sbjct: 409 VNNGFLVTLNAPLAQLYNDRSVLESFHCAAYSQILRRYWPETF------DDSKMRHLMIS 462
Query: 684 CILATDLAAFFPNLDKIREL---YRSDEAQFSWDD---PSHRDLAMAISMTAADLSASAK 737
ILATD+ F + K+ +L R + + WD+ + L A+ + AD+S +
Sbjct: 463 SILATDMGLHFDYMRKLGDLQGKLRPNNSTEDWDEGVKNEQKALTCALLIKCADISNVTR 522
Query: 738 PWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEE--QPASQVGFLSQICIPCY 795
+ I+ +K++ EEF Q E I +M K ++ SQ+ F++ +P +
Sbjct: 523 RHDAAIQWMKILSEEFSRQATMENEL-EIKTSLMSEPKQDKLSLTTSQLKFMNLFALPLF 581
Query: 796 DMLYRILP 803
+ ILP
Sbjct: 582 QGVADILP 589
>UniRef50_A1K343 Cluster: HD-domain containing protein; n=2;
Proteobacteria|Rep: HD-domain containing protein -
Azoarcus sp. (strain BH72)
Length = 999
Score = 63.7 bits (148), Expect = 2e-08
Identities = 42/126 (33%), Positives = 67/126 (53%), Gaps = 5/126 (3%)
Query: 331 DQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINR 390
++L+ IL +RL NAD ASL +V S + P +++ + P
Sbjct: 446 ERLLAHILGVGKRLCNADAASLLMVTPEGSLRFALRSRNDPLPQMEIPLHDPHTGAPNEH 505
Query: 391 GIAGHVALSGETMNIPDAYSDYRFN----RDVDEATGYKTISILCMPIKVE-GKVIGVVQ 445
+A VAL +T+ I D ++ RF+ R +D ATGY+T+S+L +P+ G+VIGV+Q
Sbjct: 506 FVAVWVALHRQTVRIDDTATETRFDVSGARGMDSATGYRTVSMLTVPMTSSGGEVIGVLQ 565
Query: 446 MVNKRD 451
+N D
Sbjct: 566 FLNATD 571
>UniRef50_Q5CXM2 Cluster: Membrane associated HD superfamily cyclic
nucleotide phosphodiesterase domain containing protein;
n=2; Cryptosporidium|Rep: Membrane associated HD
superfamily cyclic nucleotide phosphodiesterase domain
containing protein - Cryptosporidium parvum Iowa II
Length = 1967
Score = 63.7 bits (148), Expect = 2e-08
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 10/149 (6%)
Query: 559 LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCH 618
LT F L +PYHN H V Y IL++ N + + LF A LCH
Sbjct: 1535 LTLFDLIHDSYNSDIPYHNIFHALQVVQVCYIILRN-FGIMLVLNDLNKFILLFAA-LCH 1592
Query: 619 DLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQ----DGHNIFSHISSED 673
D+DH G N +++ + S LA Y S LE+HH N ++L + D F+ ++
Sbjct: 1593 DIDHPGVNNCFLTISNSKLALKYNDNSILENHHCNYIFSLLDKCQDLDIRKNFNDFEKKN 1652
Query: 674 YKEILGFIRHCILATDLAAFFPNLDKIRE 702
++ I FIR +L+TD++ L + E
Sbjct: 1653 FRRI--FIR-SVLSTDMSYHNTLLSNLEE 1678
Score = 51.2 bits (117), Expect = 1e-04
Identities = 32/91 (35%), Positives = 43/91 (47%)
Query: 729 AADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLS 788
AAD+S P+ I K +I EEF Q E G P MD + +Q+GFL
Sbjct: 1744 AADISNPITPFPICAKWSSLIVEEFNYQSKLESQFGLPITPFMDLKDDITKIEAQIGFLE 1803
Query: 789 QICIPCYDMLYRILPNTKPMYAMATKNLNRW 819
I IP + +L RI+P + + A KN W
Sbjct: 1804 FIIIPQWKLLSRIIPKSIILLKQAEKNRELW 1834
>UniRef50_Q54HY3 Cluster: Putative uncharacterized protein Pde4;
n=2; Dictyostelium discoideum|Rep: Putative
uncharacterized protein Pde4 - Dictyostelium discoideum
AX4
Length = 771
Score = 63.7 bits (148), Expect = 2e-08
Identities = 35/100 (35%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 719 RDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEE 778
R L M IS+ AD+S +KPW + + EFY QGDKE+ + MDRNKP
Sbjct: 581 RLLLMKISIKCADISNPSKPWNLYTNWSNRVTSEFYKQGDKEKESNMDVSAFMDRNKPAT 640
Query: 779 QPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNR 818
Q+ F++ P Y++ P K Y NL+R
Sbjct: 641 TKC-QINFINIFVAPIYEIWSHHFPQFKLCYQNILSNLSR 679
Score = 60.1 bits (139), Expect = 3e-07
Identities = 48/172 (27%), Positives = 72/172 (41%), Gaps = 7/172 (4%)
Query: 549 FDMTQFDITTLTRFTLTVKKNY-RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYNKAS 606
F+ + I F ++ Y T PYHN H V H + Y I KS K D S
Sbjct: 313 FEKFKIGIDCFKNFMRKIESGYDSTNPYHNSIHATDVLHNLNYFIEKSFGKFLTDIELFS 372
Query: 607 SRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNI 665
+ +A + HD H G N + + S LA Y S LE++H + I+ + I
Sbjct: 373 ----MILAAIIHDFKHPGVNNHFQINSKSRLALKYNDKSILENYHLHQAFIIMNEPESGI 428
Query: 666 FSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPS 717
+S KEI I +L+TD+A F + + + + S + PS
Sbjct: 429 LLKLSDSVRKEIRETIIALVLSTDMAKHFNLVGRFKSMANSFPTTTNTQQPS 480
>UniRef50_A0L8S2 Cluster: Metal dependent phosphohydrolase; n=6;
Proteobacteria|Rep: Metal dependent phosphohydrolase -
Magnetococcus sp. (strain MC-1)
Length = 746
Score = 63.3 bits (147), Expect = 3e-08
Identities = 48/141 (34%), Positives = 78/141 (55%), Gaps = 25/141 (17%)
Query: 331 DQLIKRILEFAQRLVNADRASLFLV----DYRNSELV-----------STVFDLKFEPGL 375
++L+++IL ++ L NAD +L+ V D E++ +T D+ F P L
Sbjct: 224 NRLLEKILLGSKELANADAGTLYRVNEAQDALKFEIIRTDSLNIAMGGTTGVDITF-PNL 282
Query: 376 DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYS----DYRFNRDVDEATGYKTISILC 431
L E K P + IA + A+ GE +N+PDAY D+ R D+ TGY+T S+L
Sbjct: 283 PLYKEGK----PNLQAIAAYAAIKGEAVNVPDAYQADGFDFSGARAFDKNTGYRTTSVLA 338
Query: 432 MPIK-VEGKVIGVVQMVNKRD 451
+P+K E ++IGV+Q++N +D
Sbjct: 339 VPMKNHENELIGVLQLINAKD 359
Score = 51.2 bits (117), Expect = 1e-04
Identities = 46/146 (31%), Positives = 68/146 (46%), Gaps = 23/146 (15%)
Query: 322 AIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKF---------- 371
A+ E S+D L+++IL Q L AD A+L+L+ L + +
Sbjct: 13 ALLVEQQSMDALLEQILVTVQDLSMADGATLYLMTESRDALEFAIMRTRSLGLAYGGTTG 72
Query: 372 ----EPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYS----DYRFNRDVDEATG 423
P L L K P + IA A G T+NI DAY D+ RD DE
Sbjct: 73 TPPPYPNLSLYANDK----PTHHLIAVECAHRGVTLNIADAYKVDQLDFTGTRDFDEQNH 128
Query: 424 YKTISILCMPIK-VEGKVIGVVQMVN 448
Y+T S+L +P+K +V+GV+Q++N
Sbjct: 129 YRTQSVLNIPLKGHHEEVVGVIQLIN 154
>UniRef50_A0BZW8 Cluster: Chromosome undetermined scaffold_14, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_14,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 454
Score = 63.3 bits (147), Expect = 3e-08
Identities = 73/321 (22%), Positives = 135/321 (42%), Gaps = 26/321 (8%)
Query: 459 DEAAFEIFSTFFGLALHHAR-LYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEP 517
+EA F+ + F+ R L ++I + Y LE + ++LD +
Sbjct: 58 EEALFQTYGFFYQTIKKFTRKLENKIYYDKTDYEATLEKFERLQIKLIPLYKELILDAQK 117
Query: 518 LNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDITTLTRFTLT-----VKKNYRT 572
L D LD K + LFD D + + L + NY
Sbjct: 118 LQRMDLDTLLDSNMAHHIYTKKELGQFSLQLFDFLNLDTIKVPKNVLNDLITEIIMNYNV 177
Query: 573 VPYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMS 631
VPYHNF H + ++ +++ +KSD+K+ + + S + +A L HDL+H+G N Y
Sbjct: 178 VPYHNFTHAFQLSQLLFSCYMKSDLKKFCNQLEIFSAI---LAGLGHDLNHKGVNNMYKI 234
Query: 632 ETASPLAAMYT-TSTLEHHHFNITVTILQQD-GHNIFSHISSEDYKEIL-GFIRHCILAT 688
+ + + + + LE+ H I+Q + H+ F ++++++ + + I ILAT
Sbjct: 235 KKSKKFNVLTSEIAVLENMHCATFFNIIQLNRQHDFFQYMTNDEERNLAKRLIITSILAT 294
Query: 689 D-------LAAFFPNLDKIRELYRS------DEAQFSWDDPSHRDLAMAISMTAADLSAS 735
D LA F ++ ++ + D +FS + R + I + A D+S
Sbjct: 295 DMSKHNKLLAKFQKRVESTKQFEQGEKNELIDMQRFSNERLEDRIFILNIMVHACDISNP 354
Query: 736 AKPWEIQIKTVKVIFEEFYDQ 756
+ + ++ +EF DQ
Sbjct: 355 TMKFNNYMNWSYLLTQEFNDQ 375
>UniRef50_A0W5Q9 Cluster: Putative GAF sensor protein; n=1;
Geobacter lovleyi SZ|Rep: Putative GAF sensor protein -
Geobacter lovleyi SZ
Length = 182
Score = 62.9 bits (146), Expect = 4e-08
Identities = 44/140 (31%), Positives = 67/140 (47%), Gaps = 10/140 (7%)
Query: 319 VVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLD 378
+V + E V +D +K + RL A+ SL L+D L V E L
Sbjct: 23 LVNSSHERSVIMDHAVKSVC----RLTGAEAGSLLLLDEFTGHLDFEVVTGGREELLPF- 77
Query: 379 MEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG 438
R+P +GIAG VA + + + D SD RF + D+ G+ T ++ +P++V G
Sbjct: 78 -----FRVPKGQGIAGWVAQNDLPIIVQDVQSDERFFKFTDQELGFTTRDMIAVPLRVNG 132
Query: 439 KVIGVVQMVNKRDDKYFGDD 458
VIGV+Q +NK + DD
Sbjct: 133 TVIGVLQAINKNSGSFNHDD 152
>UniRef50_Q7YYN8 Cluster: Phosphdiesterase, possible; n=2;
Cryptosporidium|Rep: Phosphdiesterase, possible -
Cryptosporidium parvum
Length = 1001
Score = 62.9 bits (146), Expect = 4e-08
Identities = 76/328 (23%), Positives = 129/328 (39%), Gaps = 42/328 (12%)
Query: 512 LLDKEPLNVDFADFYLDPFR-FDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTL 564
+L KE N+D + +D + EF + RD D Q + + F
Sbjct: 652 ILSKEWYNIDLLELSIDEIKEIAEFLIYYRFREVIRDKDDYDDDVLSWQINKRKIKNFVS 711
Query: 565 TVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDH 622
+ K Y P+HNF H +++ + L K V+ Y + L ++ L HDLDH
Sbjct: 712 ELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRH---YVNSLEAYCLIISSLSHDLDH 768
Query: 623 RGYTNKYMSE-------------------------TASPLAAMYTTSTLEHHHFNITVTI 657
G TN + E T S L S LE+HH ++ I
Sbjct: 769 PGLTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVI 828
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYR--SDEAQFSWDD 715
L + NI +S+ Y E+ + + IL TD+ D + + S ++ +
Sbjct: 829 LNDEASNIMPPTTSKYYSELHKMMINSILFTDMFQHKYLRDLVLNFNKNYSSNSRSIEVE 888
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNK 775
+ L + I + + D+S I +K ++++EE +Q ++ + I + D
Sbjct: 889 AQKKKLYLLILLHSVDISNPLMNTNIYLKWSRLVYEELENQ---KKLKLMLNISLNDTTD 945
Query: 776 PEEQPASQVGFLSQICIPCYDMLYRILP 803
+ Q F+S ICIP + L + P
Sbjct: 946 TYDYTKLQTSFISSICIPYFQALLKFDP 973
>UniRef50_Q5BYM4 Cluster: SJCHGC06481 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC06481 protein - Schistosoma
japonicum (Blood fluke)
Length = 178
Score = 62.9 bits (146), Expect = 4e-08
Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Query: 717 SHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKP 776
+ +DL M I + +D+S A+P + + + EF+ Q D E+ G P MDR+K
Sbjct: 36 AQKDLVMVIILKISDISNEARPLNVAGPWINRLLAEFFHQSDYEKLVGLPVAPFMDRHKV 95
Query: 777 EEQPASQVGFLSQICIPCYDMLYRILPNTKPM 808
+ ASQ GF+ + +P ++ L ++LP KP+
Sbjct: 96 TKS-ASQCGFIRFVILPLFESLAKLLPEVKPI 126
>UniRef50_A3FPW6 Cluster: Phosphdiesterase, putative; n=1;
Cryptosporidium parvum Iowa II|Rep: Phosphdiesterase,
putative - Cryptosporidium parvum Iowa II
Length = 1206
Score = 62.9 bits (146), Expect = 4e-08
Identities = 76/328 (23%), Positives = 129/328 (39%), Gaps = 42/328 (12%)
Query: 512 LLDKEPLNVDFADFYLDPFR-FDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTL 564
+L KE N+D + +D + EF + RD D Q + + F
Sbjct: 857 ILSKEWYNIDLLELSIDEIKEIAEFLIYYRFREVIRDKDDYDDDVLSWQINKRKIKNFVS 916
Query: 565 TVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDH 622
+ K Y P+HNF H +++ + L K V+ Y + L ++ L HDLDH
Sbjct: 917 ELIKYYHEENPFHNFHHAVSISITLNNWLDKPSVRH---YVNSLEAYCLIISSLSHDLDH 973
Query: 623 RGYTNKYMSE-------------------------TASPLAAMYTTSTLEHHHFNITVTI 657
G TN + E T S L S LE+HH ++ I
Sbjct: 974 PGLTNDMIKELNILSRKVLQEFTTDEQFFEILQNNTLSTLKIYNNFSVLENHHSSLLFVI 1033
Query: 658 LQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYR--SDEAQFSWDD 715
L + NI +S+ Y E+ + + IL TD+ D + + S ++ +
Sbjct: 1034 LNDEASNIMPPTTSKYYSELHKMMINSILFTDMFQHKYLRDLVLNFNKNYSSNSRSIEVE 1093
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNK 775
+ L + I + + D+S I +K ++++EE +Q ++ + I + D
Sbjct: 1094 AQKKKLYLLILLHSVDISNPLMNTNIYLKWSRLVYEELENQ---KKLKLMLNISLNDTTD 1150
Query: 776 PEEQPASQVGFLSQICIPCYDMLYRILP 803
+ Q F+S ICIP + L + P
Sbjct: 1151 TYDYTKLQTSFISSICIPYFQALLKFDP 1178
>UniRef50_Q1II68 Cluster: Metal dependent phosphohydrolase; n=1;
Acidobacteria bacterium Ellin345|Rep: Metal dependent
phosphohydrolase - Acidobacteria bacterium (strain
Ellin345)
Length = 686
Score = 62.5 bits (145), Expect = 5e-08
Identities = 31/77 (40%), Positives = 53/77 (68%), Gaps = 7/77 (9%)
Query: 382 KEIRMPIN-RGIAGHVALSGETMNIPDAYS-----DYRFNRDVDEATGYKTISILCMPIK 435
+E+ +PI+ + IAG+VAL GE +N+ DAY Y NR DE +GY+T SIL +P++
Sbjct: 237 REVTIPISEKSIAGYVALRGEIVNLRDAYDLPHEVPYAINRKFDEDSGYRTCSILAVPMR 296
Query: 436 -VEGKVIGVVQMVNKRD 451
+ +++GV+Q++N ++
Sbjct: 297 DQKEEIVGVIQLINAKN 313
>UniRef50_Q6BSL2 Cluster: Similar to tr|O94034 Candida albicans
Nucleotide phosphodiesterase; n=2;
Saccharomycetaceae|Rep: Similar to tr|O94034 Candida
albicans Nucleotide phosphodiesterase - Debaryomyces
hansenii (Yeast) (Torulaspora hansenii)
Length = 611
Score = 62.5 bits (145), Expect = 5e-08
Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 7/156 (4%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT-ILQQDGHNIF 666
LAL +A L HD+ H G TN +M + ++P++ +Y S LE +H + + IL + I
Sbjct: 385 LALLIAALGHDVGHPGVTNAFMIKHSAPMSLIYNERSVLELYHSAVFINKILAINWPGIL 444
Query: 667 S-HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAI 725
S +I + + I CILATD+A F +DK+ +++D + + +L ++
Sbjct: 445 SVNIDRKTKISLKNLIISCILATDMAEHFEYIDKLAH-FKADRYML---EVNRVNLISSL 500
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKER 761
+ AD+S +P + + V+ EF + E+
Sbjct: 501 LIKCADISNVTRPLRVSSQWALVLGREFCEVSTLEK 536
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,019,409,867
Number of Sequences: 1657284
Number of extensions: 43211594
Number of successful extensions: 109733
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 108272
Number of HSP's gapped (non-prelim): 889
length of query: 929
length of database: 575,637,011
effective HSP length: 108
effective length of query: 821
effective length of database: 396,650,339
effective search space: 325649928319
effective search space used: 325649928319
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 77 (35.1 bits)
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