Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002043-TA|BGIBMGA002043-PA|IPR003018|GAF,
IPR002073|3'5'-cyclic nucleotide phosphodiesterase,
IPR003607|Metal-dependent phosphohydrolase, HD region
(929 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR536567-1|CAG38804.1| 779|Homo sapiens PDE10A protein. 483 e-135
BC104860-1|AAI04861.1| 779|Homo sapiens phosphodiesterase 10A p... 483 e-135
BC104858-1|AAI04859.1| 779|Homo sapiens phosphodiesterase 10A p... 483 e-135
AL160160-1|CAH72023.1| 779|Homo sapiens phosphodiesterase 10A p... 483 e-135
AL136130-1|CAI20436.1| 779|Homo sapiens phosphodiesterase 10A p... 483 e-135
AL117345-1|CAB92797.2| 779|Homo sapiens phosphodiesterase 10A p... 483 e-135
AF127480-1|AAD32596.1| 807|Homo sapiens 3',5'-cyclic nucleotide... 483 e-135
AF127479-1|AAD32595.1| 779|Homo sapiens 3',5'-cyclic nucleotide... 483 e-135
AB041798-3|BAB16383.1| 714|Homo sapiens phosphodiesterase 10A1 ... 483 e-135
AB026816-1|BAA84467.1| 789|Homo sapiens 3',5'-cyclic nucleotide... 483 e-135
AB020593-1|BAA78034.1| 779|Homo sapiens 3',5'-Cyclic nucleotide... 483 e-135
BC114431-1|AAI14432.1| 934|Homo sapiens phosphodiesterase 11A p... 367 e-100
BC112393-1|AAI12394.1| 934|Homo sapiens phosphodiesterase 11A p... 367 e-100
AJ278682-1|CAC15567.1| 684|Homo sapiens cAMP/cGMP cyclic nucleo... 367 e-100
AB048423-2|BAB62712.1| 934|Homo sapiens phosphodiesterase 11A4 ... 367 e-100
AB048423-1|BAB62713.2| 684|Homo sapiens phosphodiesterase 11A3 ... 367 e-100
AB038041-1|BAB16372.1| 684|Homo sapiens phosphodiesterase 11A3 ... 367 e-100
AB036704-1|BAB16371.1| 934|Homo sapiens phosphodiesterase 11A p... 367 e-100
AF281865-1|AAG32023.1| 576|Homo sapiens cAMP/cGMP phosphodieste... 364 e-100
AK131525-1|BAD18664.1| 685|Homo sapiens protein ( Homo sapiens ... 347 1e-94
U67733-1|AAC51320.1| 941|Homo sapiens PDE2A3 protein. 346 3e-94
BC040974-1|AAH40974.1| 941|Homo sapiens phosphodiesterase 2A, c... 345 4e-94
AY495087-1|AAS75513.1| 932|Homo sapiens cGMP-stimulated phospho... 344 8e-94
AJ251509-1|CAB82573.1| 490|Homo sapiens cyclic nucleotide phosp... 332 3e-90
AB048423-3|BAB62714.1| 490|Homo sapiens phosphodiesterase 11A1 ... 332 3e-90
D89094-1|BAA28945.1| 875|Homo sapiens 3',5'-cyclic GMP phosphod... 319 3e-86
BC126233-1|AAI26234.1| 875|Homo sapiens phosphodiesterase 5A, c... 319 3e-86
AY264918-1|AAP21809.1| 833|Homo sapiens phosphodiesterase 5A pr... 319 3e-86
AJ004865-1|CAA06170.1| 875|Homo sapiens cGMP-binding, cGMP-spec... 319 3e-86
AF043731-1|AAC63967.1| 875|Homo sapiens cGMP-binding cGMP-speci... 319 3e-86
AB015656-1|BAA81667.1| 833|Homo sapiens cGMP-binding cGMP speci... 319 3e-86
AB001635-1|BAA33372.2| 875|Homo sapiens cGMP-binding cGMP-speci... 319 3e-86
AC012499-1|AAY14803.1| 325|Homo sapiens unknown protein. 247 2e-64
U20212-1|AAA92886.1| 858|Homo sapiens cone photoreceptor cGMP-p... 246 2e-64
X94354-1|CAA64079.1| 858|Homo sapiens cone cGMP phosphodiestera... 246 4e-64
AL356214-7|CAH72330.1| 858|Homo sapiens phosphodiesterase 6C, c... 246 4e-64
AL157396-4|CAH73839.1| 858|Homo sapiens phosphodiesterase 6C, c... 246 4e-64
X90587-1|CAA62215.1| 617|Homo sapiens Rod cGMP phosphodiesteras... 245 7e-64
X66142-1|CAA46932.1| 854|Homo sapiens 3',5'-cyclic-nucleotide ... 245 7e-64
U31973-1|AAA96392.1| 858|Homo sapiens phosphodiesterase A' subu... 245 7e-64
S41458-1|AAB22690.1| 854|Homo sapiens rod cGMP phosphodiesteras... 245 7e-64
BT009794-1|AAP88796.1| 853|Homo sapiens phosphodiesterase 6B, c... 244 1e-63
BC000249-1|AAH00249.1| 853|Homo sapiens phosphodiesterase 6B, c... 244 1e-63
X62692-1|CAA44569.1| 854|Homo sapiens cGMP phosphodiesterase be... 243 3e-63
M26061-1|AAB69155.1| 860|Homo sapiens PDEA protein. 241 1e-62
BC035909-1|AAH35909.1| 860|Homo sapiens phosphodiesterase 6A, c... 241 1e-62
AC093752-1|AAY40985.1| 331|Homo sapiens unknown protein. 224 1e-57
BT007016-1|AAP35662.1| 533|Homo sapiens phosphodiesterase 9A pr... 152 5e-36
BC009047-1|AAH09047.1| 533|Homo sapiens phosphodiesterase 9A pr... 152 5e-36
AY701187-1|AAV84271.1| 485|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY242121-1|AAO88210.1| 492|Homo sapiens type 9 cGMP-specific ph... 152 5e-36
AY196314-1|AAO34700.1| 386|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196313-1|AAO34699.1| 386|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196312-1|AAO34698.1| 567|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196311-1|AAO34697.1| 552|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196310-1|AAO34696.1| 526|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196309-1|AAO34695.1| 376|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196308-1|AAO34694.1| 386|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196307-1|AAO34693.1| 491|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196306-1|AAO34692.1| 459|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196305-1|AAO34691.1| 376|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196304-1|AAO34690.1| 433|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196303-1|AAO34689.1| 507|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196302-1|AAO34688.1| 386|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196301-1|AAO34687.1| 386|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196300-1|AAO34686.1| 492|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AY196299-1|AAO34685.1| 540|Homo sapiens phosphodiesterase PDE9A... 152 5e-36
AP001747-1|BAA95552.1| 593|Homo sapiens CGMP-specific 3',5'-cyc... 152 5e-36
AF067226-1|AAC26726.1| 465|Homo sapiens cGMP phosphodiesterase ... 152 5e-36
AF067225-1|AAC26725.1| 466|Homo sapiens cGMP phosphodiesterase ... 152 5e-36
AF067224-1|AAC26724.1| 533|Homo sapiens cGMP phosphodiesterase ... 152 5e-36
AF067223-1|AAC26723.1| 593|Homo sapiens cGMP phosphodiesterase ... 152 5e-36
AF048837-1|AAC39778.1| 593|Homo sapiens cGMP-specific phosphodi... 152 5e-36
AB017602-1|BAA88847.1| 593|Homo sapiens cGMP phosphodiesterase ... 152 5e-36
AY266363-1|AAP31235.1| 255|Homo sapiens phosphodiesterase isozy... 124 1e-27
U97584-1|AAC25679.1| 647|Homo sapiens cyclic AMP-specific phosp... 117 2e-25
U68532-1|AAC63832.1| 647|Homo sapiens cyclic AMP specific phosp... 117 2e-25
U18087-1|AAC50458.1| 686|Homo sapiens 3',5'-cyclic AMP phosphod... 117 2e-25
S75213-1|AAB33798.1| 667|Homo sapiens type-IVA cyclic AMP speci... 117 2e-25
M37744-1|AAA69697.1| 775|Homo sapiens protein ( Human cyclic AM... 117 2e-25
L20965-1|AAA03588.1| 886|Homo sapiens phosphodiesterase protein. 117 2e-25
BC038234-1|AAH38234.1| 647|Homo sapiens phosphodiesterase 4A, c... 117 2e-25
BC019864-1|AAH19864.1| 647|Homo sapiens phosphodiesterase 4A, c... 117 2e-25
AY618547-1|AAU82096.1| 860|Homo sapiens cyclic AMP phosphodiest... 117 2e-25
AY593872-1|AAT00628.1| 864|Homo sapiens cAMP-specific phosphodi... 117 2e-25
AF073745-1|AAD34217.2| 825|Homo sapiens cyclic AMP-specific pho... 117 2e-25
AF069491-3|AAC35013.1| 647|Homo sapiens cAMP specific phosphodi... 117 2e-25
AF069491-2|AAC35015.1| 860|Homo sapiens putative novel cAMP spe... 117 2e-25
AF069491-1|AAC35012.1| 886|Homo sapiens cAMP specific phosphodi... 117 2e-25
U02882-1|AAC13745.1| 604|Homo sapiens 3',5'-cyclic AMP phosphod... 115 7e-25
U50159-1|AAA97892.1| 673|Homo sapiens cAMP-specific phoshodiest... 115 9e-25
U50158-1|AAA97891.1| 507|Homo sapiens cAMP-specific phosphodies... 115 9e-25
U50157-1|AAA97890.1| 585|Homo sapiens cAMP-specific phosphodies... 115 9e-25
L20970-1|AAA03592.1| 673|Homo sapiens phosphodiesterase protein. 115 9e-25
L20969-1|AAC00042.1| 809|Homo sapiens cyclic AMP phosphodiester... 115 9e-25
AY388960-1|AAQ90404.1| 679|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AY245867-1|AAP75761.1| 679|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AY245866-1|AAP75760.1| 748|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AF536976-1|AAN10118.1| 748|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AF536975-1|AAN10117.1| 518|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AF012074-1|AAC00070.1| 507|Homo sapiens cAMP-specific phosphodi... 115 9e-25
AF012073-1|AAC00069.1| 745|Homo sapiens cAMP-specific phosphodi... 115 9e-25
U67932-1|AAB65772.1| 456|Homo sapiens cAMP phosphodiesterase PD... 114 1e-24
L12052-1|AAA35644.2| 482|Homo sapiens cAMP phosphodiesterase PD... 114 1e-24
BC126360-1|AAI26361.1| 456|Homo sapiens phosphodiesterase 7A pr... 114 1e-24
AF536977-1|AAN10119.1| 687|Homo sapiens cAMP-specific phosphodi... 114 1e-24
U40370-1|AAC50436.1| 535|Homo sapiens 3',5' cyclic nucleotide p... 114 2e-24
BC022480-1|AAH22480.1| 545|Homo sapiens phosphodiesterase 1A, c... 114 2e-24
AL110263-1|CAB53703.1| 519|Homo sapiens hypothetical protein pr... 114 2e-24
AJ401610-1|CAC82208.1| 519|Homo sapiens 3'5' cyclic nucleotide ... 114 2e-24
AB038224-9|BAB20054.1| 518|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-8|BAB20053.1| 501|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-7|BAB20057.1| 511|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-6|BAB20052.1| 552|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-5|BAB20050.1| 535|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-4|BAB20056.1| 545|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-3|BAB20051.1| 536|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-2|BAB20049.1| 519|Homo sapiens calmodulin-dependent ph... 114 2e-24
AB038224-1|BAB20055.1| 529|Homo sapiens calmodulin-dependent ph... 114 2e-24
BC036319-1|AAH36319.1| 518|Homo sapiens PDE4D protein protein. 113 2e-24
U88713-1|AAC51916.1| 700|Homo sapiens phosphodiesterase 4C prot... 110 2e-23
U88712-1|AAC51915.1| 606|Homo sapiens phosphodiesterase 4C prot... 110 2e-23
U66348-1|AAB96877.1| 518|Homo sapiens PDE4C-delta54 protein. 110 2e-23
U66347-1|AAB96876.1| 426|Homo sapiens PDE4C-426 protein. 110 2e-23
U66346-1|AAB96875.1| 791|Homo sapiens PDE4C-791 protein. 110 2e-23
BC109068-1|AAI09069.1| 549|Homo sapiens PDE4C protein protein. 110 2e-23
BC109067-1|AAI09068.1| 481|Homo sapiens PDE4C protein protein. 110 2e-23
AF157816-3|AAD47055.1| 606|Homo sapiens cAMP specific phosphodi... 110 2e-23
AF157816-2|AAD47054.1| 680|Homo sapiens cAMP specific phosphodi... 110 2e-23
AF157816-1|AAD47053.1| 712|Homo sapiens cAMP specific phosphodi... 110 2e-23
AC005759-5|AAC83049.1| 426|Homo sapiens PDE4C-426 protein. 110 2e-23
AC005759-3|AAC83051.1| 518|Homo sapiens PDE4C-delta54 protein. 110 2e-23
AC005759-1|AAC83050.1| 782|Homo sapiens PDE4C-791 protein. 110 2e-23
U85048-1|AAB96381.1| 721|Homo sapiens cyclic AMP specific phosp... 110 3e-23
M97515-1|AAA36426.1| 564|Homo sapiens phosphodiesterase protein. 110 3e-23
L20971-1|AAA03593.1| 564|Homo sapiens phosphodiesterase protein. 110 3e-23
L20966-1|AAA03589.1| 736|Homo sapiens phosphodiesterase protein. 110 3e-23
L12686-1|AAA35643.1| 606|Homo sapiens 3',5'-cyclic AMP phosphod... 110 3e-23
BC105040-1|AAI05041.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
BC101480-1|AAI01481.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL592285-3|CAH70628.1| 721|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL592285-1|CAH70626.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL359701-3|CAI23101.1| 721|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL359701-2|CAI23100.1| 564|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL359701-1|CAI23099.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL357273-3|CAH73004.1| 721|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL357273-1|CAH73002.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL109926-4|CAI21751.1| 721|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL109926-3|CAI21750.1| 564|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AL109926-2|CAI21749.1| 736|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
AB209081-1|BAD92318.1| 726|Homo sapiens phosphodiesterase 4B, c... 110 3e-23
Z46632-1|CAA86601.1| 712|Homo sapiens 3',5'-cyclic AMP phosphod... 109 4e-23
AF332652-1|AAK57640.1| 424|Homo sapiens cAMP-specific cyclic nu... 109 6e-23
U18088-1|AAA98540.1| 323|Homo sapiens 3',5'-cyclic AMP phosphod... 108 8e-23
AF069491-4|AAC35014.1| 323|Homo sapiens cAMP specific phosphodi... 108 8e-23
U40372-1|AAA96961.1| 564|Homo sapiens PDE1C3 protein. 106 4e-22
U40371-1|AAC50437.1| 634|Homo sapiens 3',5' cyclic nucleotide p... 106 4e-22
BC022525-1|AAH22525.1| 634|Homo sapiens PDE1C protein protein. 106 4e-22
BC022479-1|AAH22479.1| 634|Homo sapiens PDE1C protein protein. 106 4e-22
AK091734-1|BAC03734.1| 769|Homo sapiens (EC 3.1.4.17). protein. 106 4e-22
AC006377-1|AAS07516.1| 591|Homo sapiens unknown protein. 106 4e-22
AC005759-2|AAC83047.1| 710|Homo sapiens CN4C_HUMAN protein. 104 1e-21
U86078-1|AAC51872.1| 536|Homo sapiens calmodulin-stimulated pho... 104 2e-21
U56976-1|AAC50769.1| 536|Homo sapiens calmodulin dependent phos... 104 2e-21
BX538092-1|CAD98011.1| 399|Homo sapiens hypothetical protein pr... 104 2e-21
BC032226-1|AAH32226.1| 536|Homo sapiens phosphodiesterase 1B, c... 104 2e-21
AJ401609-1|CAC82207.1| 516|Homo sapiens 3'5' cyclic nucleotide ... 104 2e-21
EF108327-1|ABL14249.1| 502|Homo sapiens phosphodiesterase PDE7B... 103 4e-21
BC075083-1|AAH75083.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
BC075082-1|AAH75082.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
AL360178-1|CAH73075.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
AL138828-4|CAI95287.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
AL133319-1|CAH73332.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
AJ251860-1|CAB92441.1| 450|Homo sapiens phosphodiesterase 7B pr... 103 4e-21
AB209990-1|BAE06072.1| 586|Homo sapiens PDE7B variant protein p... 103 4e-21
AB038040-1|BAA96537.1| 450|Homo sapiens cyclic nucleotide phosp... 103 4e-21
BC075822-1|AAH75822.1| 829|Homo sapiens phosphodiesterase 8A pr... 98 1e-19
BC060762-1|AAH60762.1| 829|Homo sapiens phosphodiesterase 8A pr... 98 1e-19
BC048317-1|AAH48317.1| 305|Homo sapiens PDE8A protein protein. 98 1e-19
AF388187-1|AAL18614.1| 582|Homo sapiens cAMP phosphodiesterase ... 98 1e-19
AF388186-1|AAL18613.1| 582|Homo sapiens cAMP phosphodiesterase ... 98 1e-19
AF388185-1|AAL18612.1| 449|Homo sapiens cAMP phosphodiesterase ... 98 1e-19
AF388184-1|AAL18611.1| 783|Homo sapiens cAMP phosphodiesterase ... 98 1e-19
AF388183-1|AAL18610.1| 829|Homo sapiens cAMP phosphodiesterase ... 98 1e-19
AF332653-1|AAK57641.1| 829|Homo sapiens cAMP-specific cyclic nu... 98 1e-19
AF056490-1|AAC39763.1| 713|Homo sapiens cAMP-specific phosphodi... 98 1e-19
U36798-1|AAB18673.1| 1141|Homo sapiens platelet cGI-PDE protein. 96 6e-19
M91667-1|AAA35912.2| 1141|Homo sapiens cGMP-inhibited cAMP phosp... 96 6e-19
BC117371-1|AAI17372.1| 1141|Homo sapiens phosphodiesterase 3A, c... 96 6e-19
BC117369-1|AAI17370.1| 1141|Homo sapiens phosphodiesterase 3A, c... 96 6e-19
AJ005036-1|CAA06304.1| 1141|Homo sapiens phosphodiesterase 3A pr... 96 6e-19
AY423729-1|AAS00492.1| 350|Homo sapiens proliferation-inducing ... 95 8e-19
AY129950-3|AAN71727.1| 788|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AY129950-2|AAN71726.1| 838|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AY129950-1|AAN71725.1| 885|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AY129949-1|AAN71724.1| 788|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AY129948-1|AAN71723.1| 838|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AL831924-1|CAD38584.1| 843|Homo sapiens hypothetical protein pr... 95 8e-19
AF079529-1|AAC69564.2| 885|Homo sapiens cAMP-specific phosphodi... 95 8e-19
AB085827-1|BAC53765.1| 865|Homo sapiens phosphodiesterase 8B4 p... 95 8e-19
AB085826-1|BAC53764.1| 830|Homo sapiens phosphodiesterase 8B3 p... 95 8e-19
AB085825-1|BAC53763.1| 788|Homo sapiens phosphodiestearse 8B2 p... 95 8e-19
AB085824-1|BAC53762.1| 885|Homo sapiens phosphodiesterase 8B1 p... 95 8e-19
X95520-1|CAA64774.1| 1112|Homo sapiens cyclic nucleotide phospho... 94 2e-18
U38178-1|AAC50724.1| 1112|Homo sapiens cyclic nucleotide phophod... 94 2e-18
D50640-1|BAA09306.1| 1112|Homo sapiens phosphodiesterase 3B prot... 94 2e-18
AY459346-1|AAR24292.1| 1112|Homo sapiens cGMP-inhibited cAMP pho... 94 2e-18
BC035144-1|AAH35144.1| 385|Homo sapiens PDE8B protein protein. 93 4e-18
U66349-1|AAB96878.1| 427|Homo sapiens PDE4C-delta109 protein. 92 1e-17
AC005759-4|AAC83048.1| 427|Homo sapiens PDE4C-delta109 protein. 92 1e-17
BC047627-1|AAH47627.1| 241|Homo sapiens PDE8B protein protein. 82 1e-14
AC073834-2|AAX93113.1| 125|Homo sapiens unknown protein. 81 2e-14
U40584-1|AAB50018.1| 184|Homo sapiens calcium/calmodulin-stimul... 72 1e-11
M94539-1|AAA58405.1| 116|Homo sapiens cyclic nucleotide phospho... 63 4e-09
L20968-1|AAA03591.1| 251|Homo sapiens phosphodiesterase protein. 55 1e-06
AL138828-3|CAI95286.1| 199|Homo sapiens phosphodiesterase 7B pr... 50 3e-05
AY266362-1|AAP31234.1| 102|Homo sapiens phosphodiesterase isozy... 48 2e-04
AC073892-1|AAY24130.1| 98|Homo sapiens unknown protein. 48 2e-04
AL109778-1|CAB52432.1| 178|Homo sapiens PDE8A; phosphodiesteras... 42 0.013
AL109687-1|CAB52020.1| 160|Homo sapiens PDE8A; phosphodiesteras... 42 0.013
X62693-1|CAA44570.1| 51|Homo sapiens cGMP phosphodiesterase b... 38 0.22
AB041798-1|BAB92963.1| 55|Homo sapiens phosphodiesterase 10A1 ... 36 0.50
AL137265-1|CAB70664.1| 992|Homo sapiens hypothetical protein pr... 33 3.5
Z85987-1|CAI42222.1| 961|Homo sapiens FYVE, RhoGEF and PH domai... 32 8.2
U11690-1|AAA57004.1| 961|Homo sapiens FGD1 protein. 32 8.2
BC034530-1|AAH34530.1| 961|Homo sapiens FYVE, RhoGEF and PH dom... 32 8.2
>CR536567-1|CAG38804.1| 779|Homo sapiens PDE10A protein.
Length = 779
Score = 483 bits (1191), Expect = e-135
Identities = 250/573 (43%), Positives = 358/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD +++ M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVISLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>BC104860-1|AAI04861.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>BC104858-1|AAI04859.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>AL160160-1|CAH72023.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>AL136130-1|CAI20436.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>AL117345-1|CAB92797.2| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>AF127480-1|AAD32596.1| 807|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A2 protein.
Length = 807
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 216 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 275
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 276 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 335
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 336 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 395
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 396 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 455
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 456 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 514
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 515 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 570
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 571 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 630
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 631 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 688
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 689 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 748
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 749 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 781
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 172 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 231
Query: 444 VQM 446
+++
Sbjct: 232 LEL 234
Score = 34.7 bits (76), Expect = 1.5
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 2/42 (4%)
Query: 95 ETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 45 EKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 84
>AF127479-1|AAD32595.1| 779|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A1 protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>AB041798-3|BAB16383.1| 714|Homo sapiens phosphodiesterase 10A1
(PDE10A1) protein.
Length = 714
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 123 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 182
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 183 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 242
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 243 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 302
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 303 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 362
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 363 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 421
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 422 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 477
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 478 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 537
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 538 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 595
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 596 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 655
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 656 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 688
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 79 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 138
Query: 444 VQM 446
+++
Sbjct: 139 LEL 141
>AB026816-1|BAA84467.1| 789|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A2 protein.
Length = 789
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 198 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 257
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 258 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 317
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 318 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 377
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 378 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 437
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 438 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 496
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 497 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 552
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 553 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 612
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 613 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 670
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 671 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 730
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 731 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 763
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
Query: 444 VQM 446
+++
Sbjct: 214 LEL 216
Score = 34.7 bits (76), Expect = 1.5
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 2/42 (4%)
Query: 95 ETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 27 EKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 66
>AB020593-1|BAA78034.1| 779|Homo sapiens 3',5'-Cyclic nucleotide
phosphodiesterase protein.
Length = 779
Score = 483 bits (1190), Expect = e-135
Identities = 250/573 (43%), Positives = 357/573 (62%), Gaps = 12/573 (2%)
Query: 253 ILYQPIITKSGKTSYVLEMWRT--KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRER 310
+L PI+T G +LE++R K+ F + +E++ + W SVA+H ++ ++
Sbjct: 188 VLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQT 247
Query: 311 NMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLK 370
++DFLLDV K F+ +V++D L++ I+ +A+ LVNADR +LF VD++N EL S +FD+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG 307
Query: 371 FEP-GLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISI 429
E G + + KEIR I +GIAG VA +GE +NIPDAY+D RFNR+VD TGY T +I
Sbjct: 308 EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI 367
Query: 430 LCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
LCMPI G VIGVVQMVNK F DE F++F+ F LALH A +Y RI E
Sbjct: 368 LCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 427
Query: 490 YRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKC--KCIISMFRD 547
YRV +E LSYH+ C E Q ++ P+ + + L F FE + M
Sbjct: 428 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRL-CKEIELFHFDIGPFENMWPGIFVYMVHR 486
Query: 548 LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASS 607
+ F++ L RF ++VKKNYR VPYHN+ H TVAH MYAIL+++ D
Sbjct: 487 SCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL----E 542
Query: 608 RLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFS 667
R L +ACLCHDLDHRG++N Y+ + PLAA+Y+TST+E HHF+ TV+ILQ +GHNIFS
Sbjct: 543 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFS 602
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISM 727
+SS +Y+++L IR I+ATDLA +F N ++ E+Y++ + ++ SHRD + + M
Sbjct: 603 TLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT--GSLNLNNQSHRDRVIGLMM 660
Query: 728 TAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFL 787
TA DL + K W + T I+ EF+ +GD+ + G PIPMMDR+K +E P Q+GF
Sbjct: 661 TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY 720
Query: 788 SQICIPCYDMLYRILPNTKPMYAMATKNLNRWK 820
+ + IPCY L +ILP T+P+ NL++W+
Sbjct: 721 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 753
Score = 39.5 bits (88), Expect = 0.054
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 387 PINRG--IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVE-GKVIGV 443
PI +G ++ +VA S +T+ + D D RF R +G + S+LC+PI G +IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 444 VQM 446
+++
Sbjct: 204 LEL 206
Score = 37.5 bits (83), Expect = 0.22
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNNAIND 136
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN D
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNNKSED 56
>BC114431-1|AAI14432.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 355 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 414
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 415 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 474
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 475 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 595 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 654
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 655 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 712
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 713 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 772
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 773 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 830
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 831 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 890
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 891 LKPMLDSVATNRSKWEELHQKRL 913
Score = 132 bits (319), Expect = 6e-30
Identities = 77/199 (38%), Positives = 119/199 (59%), Gaps = 9/199 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVS 364
++ N F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS
Sbjct: 197 KKHNERQFFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 365 TVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
FD+ L E+++P +GI G+V GET+NIPDAY D RFN ++D+
Sbjct: 256 KFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315
Query: 422 TGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++ F G+A+ +A+L
Sbjct: 316 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 375
Query: 480 YDRIMRKEQKYRVALEVLS 498
+ ++ ++ R LEV++
Sbjct: 376 FAASRKEYERSRALLEVVN 394
>BC112393-1|AAI12394.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 355 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 414
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 415 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 474
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 475 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 595 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 654
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 655 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 712
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 713 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 772
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 773 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 830
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 831 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 890
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 891 LKPMLDSVATNRSKWEELHQKRL 913
Score = 132 bits (319), Expect = 6e-30
Identities = 77/199 (38%), Positives = 119/199 (59%), Gaps = 9/199 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVS 364
++ N F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS
Sbjct: 197 KKHNERQFFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 365 TVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
FD+ L E+++P +GI G+V GET+NIPDAY D RFN ++D+
Sbjct: 256 KFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315
Query: 422 TGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++ F G+A+ +A+L
Sbjct: 316 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 375
Query: 480 YDRIMRKEQKYRVALEVLS 498
+ ++ ++ R LEV++
Sbjct: 376 FAASRKEYERSRALLEVVN 394
>AJ278682-1|CAC15567.1| 684|Homo sapiens cAMP/cGMP cyclic
nucleotide phosphodiesterase 11A3 protein.
Length = 684
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 165 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 224
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 225 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 284
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 285 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 344
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 345 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 404
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 405 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 462
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 463 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 522
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 523 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 580
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 581 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 640
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 641 LKPMLDSVATNRSKWEELHQKRL 663
Score = 75.8 bits (178), Expect = 7e-13
Identities = 36/90 (40%), Positives = 61/90 (67%), Gaps = 2/90 (2%)
Query: 411 DYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFST 468
D RFN ++D+ TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++
Sbjct: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
Query: 469 FFGLALHHARLYDRIMRKEQKYRVALEVLS 498
F G+A+ +A+L+ ++ ++ R LEV++
Sbjct: 115 FCGIAISNAQLFAASRKEYERSRALLEVVN 144
>AB048423-2|BAB62712.1| 934|Homo sapiens phosphodiesterase 11A4
protein.
Length = 934
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 355 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 414
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 415 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 474
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 475 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 595 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 654
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 655 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 712
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 713 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 772
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 773 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 830
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 831 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 890
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 891 LKPMLDSVATNRSKWEELHQKRL 913
Score = 132 bits (319), Expect = 6e-30
Identities = 77/199 (38%), Positives = 119/199 (59%), Gaps = 9/199 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVS 364
++ N F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS
Sbjct: 197 KKHNERQFFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 365 TVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
FD+ L E+++P +GI G+V GET+NIPDAY D RFN ++D+
Sbjct: 256 KFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315
Query: 422 TGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++ F G+A+ +A+L
Sbjct: 316 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 375
Query: 480 YDRIMRKEQKYRVALEVLS 498
+ ++ ++ R LEV++
Sbjct: 376 FAASRKEYERSRALLEVVN 394
>AB048423-1|BAB62713.2| 684|Homo sapiens phosphodiesterase 11A3
protein.
Length = 684
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 165 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 224
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 225 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 284
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 285 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 344
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 345 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 404
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 405 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 462
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 463 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 522
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 523 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 580
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 581 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 640
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 641 LKPMLDSVATNRSKWEELHQKRL 663
Score = 75.8 bits (178), Expect = 7e-13
Identities = 36/90 (40%), Positives = 61/90 (67%), Gaps = 2/90 (2%)
Query: 411 DYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFST 468
D RFN ++D+ TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++
Sbjct: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
Query: 469 FFGLALHHARLYDRIMRKEQKYRVALEVLS 498
F G+A+ +A+L+ ++ ++ R LEV++
Sbjct: 115 FCGIAISNAQLFAASRKEYERSRALLEVVN 144
>AB038041-1|BAB16372.1| 684|Homo sapiens phosphodiesterase 11A3
protein.
Length = 684
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 165 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 224
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 225 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 284
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 285 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 344
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 345 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 404
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 405 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 462
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 463 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 522
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 523 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 580
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 581 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 640
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 641 LKPMLDSVATNRSKWEELHQKRL 663
Score = 75.8 bits (178), Expect = 7e-13
Identities = 36/90 (40%), Positives = 61/90 (67%), Gaps = 2/90 (2%)
Query: 411 DYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFST 468
D RFN ++D+ TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++
Sbjct: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
Query: 469 FFGLALHHARLYDRIMRKEQKYRVALEVLS 498
F G+A+ +A+L+ ++ ++ R LEV++
Sbjct: 115 FCGIAISNAQLFAASRKEYERSRALLEVVN 144
>AB036704-1|BAB16371.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 367 bits (902), Expect = e-100
Identities = 204/563 (36%), Positives = 316/563 (56%), Gaps = 21/563 (3%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE++ + + +A+ +L+ ++E S LL+VV +FEE L++++K+I+ A
Sbjct: 355 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 414
Query: 342 QRLVNADRASLFLVD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRG 391
Q L+ +R S+ L++ ++ EL+S E MEK IN
Sbjct: 415 QTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNS 474
Query: 392 IAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKR 450
IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+
Sbjct: 475 IAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 451 DDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQA 510
D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC + EV
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 511 MLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTV 566
PL + A D + D F D + MF +L + +F D TL R+ LTV
Sbjct: 595 FKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTV 654
Query: 567 KKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYT 626
+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDHRG
Sbjct: 655 RKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTN 712
Query: 627 NKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ I
Sbjct: 713 NAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 772
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI +
Sbjct: 773 LATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQV 830
Query: 746 VKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPN 804
+++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++
Sbjct: 831 AELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK 890
Query: 805 TKPMYAMATKNLNRWKARADKIL 827
KPM N ++W+ K L
Sbjct: 891 LKPMLDSVATNRSKWEELHQKRL 913
Score = 132 bits (319), Expect = 6e-30
Identities = 77/199 (38%), Positives = 119/199 (59%), Gaps = 9/199 (4%)
Query: 308 RERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYR---NSELVS 364
++ N F L++VK I ++ L L +IL F +V+ADR SLFLV+ LVS
Sbjct: 197 KKHNERQFFLELVKDISNDL-DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 365 TVFDLKFEPGL---DLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEA 421
FD+ L E+++P +GI G+V GET+NIPDAY D RFN ++D+
Sbjct: 256 KFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315
Query: 422 TGYKTISILCMPIK-VEGKVIGVVQMVNK-RDDKYFGDDDEAAFEIFSTFFGLALHHARL 479
TGYKT S+LCMPI+ +G++IGV Q +NK + F +DDE +++ F G+A+ +A+L
Sbjct: 316 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 375
Query: 480 YDRIMRKEQKYRVALEVLS 498
+ ++ ++ R LEV++
Sbjct: 376 FAASRKEYERSRALLEVVN 394
>AF281865-1|AAG32023.1| 576|Homo sapiens cAMP/cGMP
phosphodiesterase 11A2 protein.
Length = 576
Score = 364 bits (896), Expect = e-100
Identities = 202/550 (36%), Positives = 310/550 (56%), Gaps = 21/550 (3%)
Query: 295 VALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFL 354
+A+ +L+ ++E S LL+VV +FEE L++++K+I+ AQ L+ +R S+ L
Sbjct: 10 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 69
Query: 355 VD---------YRNSELVSTVFDLKFEPGLDLDMEKKEIR-MPINRGIAGHVALSGETMN 404
++ ++ EL+S E MEK IN IA VA +G +N
Sbjct: 70 LEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVN 129
Query: 405 IPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMVNKRDDKYFGDDDEAAF 463
I DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q++N+ D K F D D+ F
Sbjct: 130 ISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLF 189
Query: 464 EIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFA 523
E F F GL +++ +YD++ + K VAL+VLSYH TC + EV PL + A
Sbjct: 190 EAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELA 249
Query: 524 --DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRFTLTVKKNYRTVPYHNFD 579
D + D F D + MF +L + +F D TL R+ LTV+KNYR V YHN+
Sbjct: 250 IDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWR 309
Query: 580 HGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAA 639
H + V M+A+L + + D LA+ V CLCHDLDHRG N + +++ S LA
Sbjct: 310 HAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQ 367
Query: 640 MYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLD 698
+Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ ++ ILATDL +F
Sbjct: 368 LYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRT 427
Query: 699 KIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGD 758
+ EL + ++ W+ +HRD+ ++ MTA DL A KPWEI + +++ EF++QGD
Sbjct: 428 EFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 485
Query: 759 KERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLN 817
+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L ++ KPM N +
Sbjct: 486 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 545
Query: 818 RWKARADKIL 827
+W+ K L
Sbjct: 546 KWEELHQKRL 555
>AK131525-1|BAD18664.1| 685|Homo sapiens protein ( Homo sapiens
cDNA FLJ16750 fis, clone ADRGL2011190, highly similar
to cGMP-dependent 3',5'-cyclic phosphodiesterase (EC
3.1.4.17). ).
Length = 685
Score = 347 bits (853), Expect = 1e-94
Identities = 201/564 (35%), Positives = 310/564 (54%), Gaps = 22/564 (3%)
Query: 275 KDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLI 334
K RF DE + H + S L + +++ + LL V K +F + + L+
Sbjct: 99 KVRFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLL 158
Query: 335 KRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAG 394
+ I+ A+ L NA+ S+FL+D +ELV+ VFD G +D E EIR+P ++GIAG
Sbjct: 159 QEIITEARNLSNAEICSVFLLD--QNELVAKVFD-----GGVVDDESYEIRIPADQGIAG 211
Query: 395 HVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKRDDK 453
HVA +G+ +NIPDAY+ F R VD++TG++T +ILC PIK E +VIGV ++VNK +
Sbjct: 212 HVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGP 271
Query: 454 YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLL 513
+F DE FS + G+++ H+ LY ++ + + +A E++ YH + E +L
Sbjct: 272 WFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH 331
Query: 514 DK-EP---LNVDFADFYLDPFRFDEFEKCKCIISMFRDL--FDMTQFDITTLTRFTLTVK 567
D +P ++ +FA F P E + I+SM +D+ + + D TL RF L VK
Sbjct: 332 DGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVK 391
Query: 568 KNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTN 627
K YR PYHN+ H ++V+H Y + K+ E +Y + ALF++C+CHDLDHRG N
Sbjct: 392 KGYRDPPYHNWMHAFSVSHFCYLLYKN--LELTNYLEDIEIFALFISCMCHDLDHRGTNN 449
Query: 628 KYMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCI 685
+ + S LAA+Y++ S +E HHF + IL G NIF H S +DY+ +L +R I
Sbjct: 450 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 509
Query: 686 LATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKT 745
LATDLA +L ++L + E + ++ H L + + MT+ DLS K W+ K
Sbjct: 510 LATDLA---HHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKI 566
Query: 746 VKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNT 805
++I++EF+ QGD E+A G P+ MMDR K P Q+ F+ I +P Y +L + P
Sbjct: 567 AELIYKEFFSQGDLEKAMGNRPMEMMDREK-AYIPELQISFMEHIAMPIYKLLQDLFPKA 625
Query: 806 KPMYAMATKNLNRWKARADKILFK 829
+Y N W + K +
Sbjct: 626 AELYERVASNREHWTKVSHKFTIR 649
>U67733-1|AAC51320.1| 941|Homo sapiens PDE2A3 protein.
Length = 941
Score = 346 bits (850), Expect = 3e-94
Identities = 200/563 (35%), Positives = 309/563 (54%), Gaps = 22/563 (3%)
Query: 276 DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIK 335
D F DE + H + S L + +++ + LL V K +F + + L++
Sbjct: 356 DLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQ 415
Query: 336 RILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGH 395
I+ A+ L NA+ S+FL+D +ELV+ VFD G +D E EIR+P ++GIAGH
Sbjct: 416 EIITEARNLSNAEICSVFLLD--QNELVAKVFD-----GGVVDDESYEIRIPADQGIAGH 468
Query: 396 VALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKRDDKY 454
VA +G+ +NIPDAY+ F R VD++TG++T +ILC PIK E +VIGV ++VNK + +
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 455 FGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLD 514
F DE FS + G+++ H+ LY ++ + + +A E++ YH + E +L D
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 515 K-EP---LNVDFADFYLDPFRFDEFEKCKCIISMFRDL--FDMTQFDITTLTRFTLTVKK 568
+P ++ +FA F P E + I+SM +D+ + + D TL RF L VKK
Sbjct: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKK 648
Query: 569 NYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNK 628
YR PYHN+ H ++V+H Y + K+ E +Y + ALF++C+CHDLDHRG N
Sbjct: 649 GYRDPPYHNWMHAFSVSHFCYLLYKN--LELTNYLEDIEIFALFISCMCHDLDHRGTNNS 706
Query: 629 YMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
+ + S LAA+Y++ S +E HHF + IL G NIF H S +DY+ +L +R IL
Sbjct: 707 FQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIIL 766
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATDLA +L ++L + E + ++ H L + + MT+ DLS K W+ K
Sbjct: 767 ATDLA---HHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIA 823
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
++I++EF+ QGD E+A G P+ MMDR K P Q+ F+ I +P Y +L + P
Sbjct: 824 ELIYKEFFSQGDLEKAMGNRPMEMMDREK-AYIPELQISFMEHIAMPIYKLLQDLFPKAA 882
Query: 807 PMYAMATKNLNRWKARADKILFK 829
+Y N W + K +
Sbjct: 883 ELYERVASNREHWTKVSHKFTIR 905
>BC040974-1|AAH40974.1| 941|Homo sapiens phosphodiesterase 2A,
cGMP-stimulated protein.
Length = 941
Score = 345 bits (848), Expect = 4e-94
Identities = 200/563 (35%), Positives = 309/563 (54%), Gaps = 22/563 (3%)
Query: 276 DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIK 335
D F DE + H + S L + +++ + LL V K +F + + L++
Sbjct: 356 DLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQ 415
Query: 336 RILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGH 395
I+ A+ L NA+ S+FL+D +ELV+ VFD G +D E EIR+P ++GIAGH
Sbjct: 416 EIITEARNLSNAEICSVFLLD--QNELVAKVFD-----GGVVDDESYEIRIPADQGIAGH 468
Query: 396 VALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKRDDKY 454
VA +G+ +NIPDAY+ F R VD++TG++T +ILC PIK E +VIGV ++VNK + +
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 455 FGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLD 514
F DE FS + G+++ H+ LY ++ + + +A E++ YH + E +L D
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 515 K-EP---LNVDFADFYLDPFRFDEFEKCKCIISMFRDL--FDMTQFDITTLTRFTLTVKK 568
+P ++ +FA F P E + I+SM +D+ + + D TL RF L VKK
Sbjct: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKK 648
Query: 569 NYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNK 628
YR PYHN+ H ++V+H Y + K+ E +Y + ALF++C+CHDLDHRG N
Sbjct: 649 GYRDPPYHNWMHAFSVSHFCYLLYKN--LELTNYLEDIEIFALFISCMCHDLDHRGTNNS 706
Query: 629 YMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
+ + S LAA+Y++ S +E HHF + IL G NIF H S +DY+ +L +R IL
Sbjct: 707 FQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIIL 766
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATDLA +L ++L + E + ++ H L + + MT+ DLS K W+ K
Sbjct: 767 ATDLA---HHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIA 823
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
++I++EF+ QGD E+A G P+ MMDR K P Q+ F+ I +P Y +L + P
Sbjct: 824 ELIYKEFFSQGDLEKAMGNRPMEMMDREK-AYIPELQISFMEHIAMPIYKLLQDLFPKAA 882
Query: 807 PMYAMATKNLNRWKARADKILFK 829
+Y N W + K +
Sbjct: 883 ELYERVASNGEHWTKVSHKFTIR 905
>AY495087-1|AAS75513.1| 932|Homo sapiens cGMP-stimulated
phosphodiesterase 4 protein.
Length = 932
Score = 344 bits (846), Expect = 8e-94
Identities = 199/563 (35%), Positives = 308/563 (54%), Gaps = 22/563 (3%)
Query: 276 DRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIK 335
D F DE + H + S L + +++ + LL V K +F + + L++
Sbjct: 347 DLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQ 406
Query: 336 RILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGH 395
I+ A+ L NA+ S+FL+D +ELV+ VFD G +D E EIR+P ++GIAGH
Sbjct: 407 EIITEARNLSNAEICSVFLLD--QNELVAKVFD-----GGVVDDESYEIRIPADQGIAGH 459
Query: 396 VALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEG-KVIGVVQMVNKRDDKY 454
VA +G+ +NIPDAY+ F R VD++TG++T +ILC PIK E +VIGV ++VNK + +
Sbjct: 460 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 519
Query: 455 FGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLD 514
F DE FS + G+++ H+ LY ++ + + +A E++ YH + E +L D
Sbjct: 520 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 579
Query: 515 K-EP---LNVDFADFYLDPFRFDEFEKCKCIISMFRDL--FDMTQFDITTLTRFTLTVKK 568
+P ++ +FA F P E + I+SM +D+ + + D TL RF L VKK
Sbjct: 580 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKK 639
Query: 569 NYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNK 628
YR PYHN+ H ++ +H Y + K+ E +Y + ALF++C+CHDLDHRG N
Sbjct: 640 GYRDPPYHNWMHAFSASHFCYLLYKN--LELTNYLEDIEIFALFISCMCHDLDHRGTNNS 697
Query: 629 YMSETASPLAAMYTT--STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCIL 686
+ + S LAA+Y++ S +E HHF + IL G NIF H S +DY+ +L +R IL
Sbjct: 698 FQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIIL 757
Query: 687 ATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTV 746
ATDLA +L ++L + E + ++ H L + + MT+ DLS K W+ K
Sbjct: 758 ATDLA---HHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIA 814
Query: 747 KVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTK 806
++I++EF+ QGD E+A G P+ MMDR K P Q+ F+ I +P Y +L + P
Sbjct: 815 ELIYKEFFSQGDLEKAMGNRPMEMMDREK-AYIPELQISFMEHIAMPIYKLLQDLFPKAA 873
Query: 807 PMYAMATKNLNRWKARADKILFK 829
+Y N W + K +
Sbjct: 874 ELYERVASNREHWTKVSHKFTIR 896
>AJ251509-1|CAB82573.1| 490|Homo sapiens cyclic nucleotide
phosphodiesterase 11A1 protein.
Length = 490
Score = 332 bits (816), Expect = 3e-90
Identities = 175/447 (39%), Positives = 261/447 (58%), Gaps = 11/447 (2%)
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQM 446
IN IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q+
Sbjct: 27 INNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQV 86
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREY 506
+N+ D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC +
Sbjct: 87 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKA 146
Query: 507 EVQAMLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRF 562
EV PL + A D + D F D + MF +L + +F D TL R+
Sbjct: 147 EVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 206
Query: 563 TLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDH 622
LTV+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDH
Sbjct: 207 LLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDH 264
Query: 623 RGYTNKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFI 681
RG N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ +
Sbjct: 265 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 324
Query: 682 RHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEI 741
+ ILATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI
Sbjct: 325 KQSILATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEI 382
Query: 742 QIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYR 800
+ +++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L +
Sbjct: 383 SRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVK 442
Query: 801 ILPNTKPMYAMATKNLNRWKARADKIL 827
+ KPM N ++W+ K L
Sbjct: 443 VNVKLKPMLDSVATNRSKWEELHQKRL 469
>AB048423-3|BAB62714.1| 490|Homo sapiens phosphodiesterase 11A1
protein.
Length = 490
Score = 332 bits (816), Expect = 3e-90
Identities = 175/447 (39%), Positives = 261/447 (58%), Gaps = 11/447 (2%)
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQM 446
IN IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q+
Sbjct: 27 INNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQV 86
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREY 506
+N+ D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC +
Sbjct: 87 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKA 146
Query: 507 EVQAMLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRF 562
EV PL + A D + D F D + MF +L + +F D TL R+
Sbjct: 147 EVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 206
Query: 563 TLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDH 622
LTV+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDH
Sbjct: 207 LLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDH 264
Query: 623 RGYTNKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFI 681
RG N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ +
Sbjct: 265 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 324
Query: 682 RHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEI 741
+ ILATDL +F + EL + ++ W+ +HRD+ ++ MTA DL A KPWEI
Sbjct: 325 KQSILATDLTLYFERRTEFFELV--SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEI 382
Query: 742 QIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYR 800
+ +++ EF++QGD+ER ++ P + DRN+ +E P Q+ ++ IC+P Y L +
Sbjct: 383 SRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVK 442
Query: 801 ILPNTKPMYAMATKNLNRWKARADKIL 827
+ KPM N ++W+ K L
Sbjct: 443 VNVKLKPMLDSVATNRSKWEELHQKRL 469
>D89094-1|BAA28945.1| 875|Homo sapiens 3',5'-cyclic GMP
phosphodiesterase protein.
Length = 875
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>BC126233-1|AAI26234.1| 875|Homo sapiens phosphodiesterase 5A,
cGMP-specific protein.
Length = 875
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>AY264918-1|AAP21809.1| 833|Homo sapiens phosphodiesterase 5A
protein.
Length = 833
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 257 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 316
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 317 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 375
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 376 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 435
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 436 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 495
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 496 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 555
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 556 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 611
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 612 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 671
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 672 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 729
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 730 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 789
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 790 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 110 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 168
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 169 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 227
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 228 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 287
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 288 NQVLLDLAS 296
>AJ004865-1|CAA06170.1| 875|Homo sapiens cGMP-binding,
cGMP-specific phosphodiesterase (HSPDE5A1) protein.
Length = 875
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>AF043731-1|AAC63967.1| 875|Homo sapiens cGMP-binding cGMP-specific
3',5'-cyclic nucleotide phosphodiesterase protein.
Length = 875
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>AB015656-1|BAA81667.1| 833|Homo sapiens cGMP-binding cGMP specific
phosphodiesterase 5A2 protein.
Length = 833
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 257 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 316
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 317 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 375
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 376 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 435
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 436 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 495
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 496 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 555
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 556 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLGILALLIAALSH 611
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 612 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 671
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 672 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 729
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 730 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 789
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 790 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 110 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 168
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 169 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 227
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 228 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 287
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 288 NQVLLDLAS 296
>AB001635-1|BAA33372.2| 875|Homo sapiens cGMP-binding cGMP-specific
phosphodiesterase protein.
Length = 875
Score = 319 bits (784), Expect = 3e-86
Identities = 201/568 (35%), Positives = 296/568 (52%), Gaps = 31/568 (5%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + + + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 299 DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 358
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLK---FEPGLDLDMEKKEIRMPINRGIAGHVAL 398
+ + ++F+VD S+ S+VF ++ E D + ++ IN A +V
Sbjct: 359 ISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDT-LTREHDANKINYMYAQYVKN 417
Query: 399 SGETMNIPDAYSDYRFNRDVDEA--TGYKTI-SILCMPIK--VEGKVIGVVQMVNKRDD- 452
+ E +NIPD D RF + + I S+LC PIK + KVIGV Q+VNK ++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 453 ----KYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEV 508
K F +DE E F F GL + + ++Y+ + R K V LEVLSYH + E E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 509 Q-----AMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTR 561
+ A + + DF F + E C I MF DL + F + L R
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 562 FTLTVKKNYR-TVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCH 618
+ L+VKKNYR V YHN+ H + A M+A LK+ + NK + LAL +A L H
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSH 653
Query: 619 DLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEIL 678
DLDHRG N Y+ + PLA +Y S +EHHHF+ + IL G+ I S +S E+YK L
Sbjct: 654 DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTL 713
Query: 679 GFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKP 738
I+ ILATDLA + + EL R + QF+ +DP ++L +A+ MTA DLSA KP
Sbjct: 714 KIIKQAILATDLALYIKRRGEFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKP 771
Query: 739 WEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDM 797
W IQ + +++ EF+DQGD+ER I P +M+R K + P+ QVGF+ IC+ Y+
Sbjct: 772 WPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEA 831
Query: 798 LYRILPNTKPMYAMATKNLNRWKARADK 825
L + + P+ KN +W+A A++
Sbjct: 832 LTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 128 bits (310), Expect = 7e-29
Identities = 78/189 (41%), Positives = 114/189 (60%), Gaps = 8/189 (4%)
Query: 316 LLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFE 372
LL++VK I + + L +I L++ADR SLFLV D N + L+S +FD+
Sbjct: 152 LLELVKDISSHL-DVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEG 210
Query: 373 PGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCM 432
L+ ++ IR+ N+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCM
Sbjct: 211 STLE-EVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
Query: 433 PIK-VEGKVIGVVQMVNKRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQK 489
PIK +V+GV Q +NK+ F + DE F + F G+ LH+A+LY+ + + ++
Sbjct: 270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKR 329
Query: 490 YRVALEVLS 498
+V L++ S
Sbjct: 330 NQVLLDLAS 338
>AC012499-1|AAY14803.1| 325|Homo sapiens unknown protein.
Length = 325
Score = 247 bits (604), Expect = 2e-64
Identities = 132/313 (42%), Positives = 188/313 (60%), Gaps = 8/313 (2%)
Query: 388 INRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQM 446
IN IA VA +G +NI DAY D RF+ + D+ +G+ S+LC+PI ++IGV Q+
Sbjct: 15 INNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQV 74
Query: 447 VNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREY 506
+N+ D K F D D+ FE F F GL +++ +YD++ + K VAL+VLSYH TC +
Sbjct: 75 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKA 134
Query: 507 EVQAMLLDKEPLNVDFA--DFYLDPFRFDEFEKCKCIISMFRDLFDMTQF--DITTLTRF 562
EV PL + A D + D F D + MF +L + +F D TL R+
Sbjct: 135 EVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 194
Query: 563 TLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDH 622
LTV+KNYR V YHN+ H + V M+A+L + + D LA+ V CLCHDLDH
Sbjct: 195 LLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQ--DILTEVEILAVIVGCLCHDLDH 252
Query: 623 RGYTNKYMSETASPLAAMYTTS-TLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFI 681
RG N + +++ S LA +Y TS TLEHHHFN V ILQ +GHNIF+++SS++Y +++ +
Sbjct: 253 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 312
Query: 682 RHCILATDLAAFF 694
+ ILATDL +F
Sbjct: 313 KQSILATDLTLYF 325
>U20212-1|AAA92886.1| 858|Homo sapiens cone photoreceptor
cGMP-phosphodiesterase alpha' subunit protein.
Length = 858
Score = 246 bits (603), Expect = 2e-64
Identities = 152/474 (32%), Positives = 246/474 (51%), Gaps = 41/474 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ +A +D + F + + TG+ ++L +PI + ++GV
Sbjct: 347 GLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFY 406
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G +L + YD++ + E + +A E+L E
Sbjct: 407 NRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEE 466
Query: 508 VQAMLLDKEPLNVDFADF-------------YLDP-------FRFDEFEKC-----KCII 542
++++L +E LNVD D DP FRF +F KC I
Sbjct: 467 IKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGI 526
Query: 543 SMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+F ++ + +F + LTR+ TV+K YR V YHN+ HG+ V M+ +L + +++
Sbjct: 527 RLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWQHGFNVGQTMFTLLMTGRLKKY 586
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
Y + A+ A CHD+DHRG N Y ++ SPLA ++ +S LE HH + T+LQ
Sbjct: 587 -YTDLEA-FAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQD 644
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN-------LDKIRELYRSDEA-QFS 712
+ NIF +++ ++ ++ I+ATDLA +F +D ++ +EA ++
Sbjct: 645 ESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYV 704
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMM 771
DP+ +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMM
Sbjct: 705 TVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
DRNK +E P QVGF+ +C Y R PM + N WK+ AD+
Sbjct: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
Score = 81.8 bits (193), Expect = 1e-14
Identities = 60/185 (32%), Positives = 93/185 (50%), Gaps = 11/185 (5%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN------SELVSTV 366
S L+++ + EE + +Q + R L+ L+ ADR S+FL RN S L+
Sbjct: 59 SALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLVVT 118
Query: 367 FDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
KFE +L KE+ P++ GI G A + +T N+PD + F+ +D+ TGY T
Sbjct: 119 PTSKFED--NLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG--LALHH-ARLYDRI 483
++L PI V +V+ V+ VNK + F DE F + F L LHH + +Y+
Sbjct: 177 KNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
Query: 484 MRKEQ 488
R+ Q
Sbjct: 237 SRRSQ 241
>X94354-1|CAA64079.1| 858|Homo sapiens cone cGMP phosphodiesterase
protein.
Length = 858
Score = 246 bits (601), Expect = 4e-64
Identities = 152/474 (32%), Positives = 246/474 (51%), Gaps = 41/474 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ +A +D + F + + TG+ ++L +PI + ++GV
Sbjct: 347 GLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFY 406
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G +L + YD++ + E + +A E+L E
Sbjct: 407 NRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEE 466
Query: 508 VQAMLLDKEPLNVDFADF-------------YLDP-------FRFDEFEKC-----KCII 542
++++L +E LNVD D DP FRF +F KC I
Sbjct: 467 IKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGI 526
Query: 543 SMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+F ++ + +F + LTR+ TV+K YR V YHN+ HG+ V M+ +L + +++
Sbjct: 527 RLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
Y + A+ A CHD+DHRG N Y ++ SPLA ++ +S LE HH + T+LQ
Sbjct: 587 -YTDLEA-FAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQD 644
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN-------LDKIRELYRSDEA-QFS 712
+ NIF +++ ++ ++ I+ATDLA +F +D ++ +EA ++
Sbjct: 645 ESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYV 704
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMM 771
DP+ +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMM
Sbjct: 705 TVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
DRNK +E P QVGF+ +C Y R PM + N WK+ AD+
Sbjct: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
Score = 85.0 bits (201), Expect = 1e-15
Identities = 61/185 (32%), Positives = 96/185 (51%), Gaps = 11/185 (5%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS--ELVSTVFDL- 369
S L+++ + EE + +Q + R L+ L+ ADR S+FL RN E+ S + D+
Sbjct: 59 SALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVT 118
Query: 370 ---KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
KFE +L KE+ P++ GI G A + +T N+PD + F+ +D+ TGY T
Sbjct: 119 PTSKFED--NLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG--LALHH-ARLYDRI 483
++L PI V +V+ V+ VNK + F DE F + F L LHH + +Y+
Sbjct: 177 KNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
Query: 484 MRKEQ 488
R+ Q
Sbjct: 237 SRRSQ 241
>AL356214-7|CAH72330.1| 858|Homo sapiens phosphodiesterase 6C,
cGMP-specific, cone, alpha prime protein.
Length = 858
Score = 246 bits (601), Expect = 4e-64
Identities = 152/474 (32%), Positives = 246/474 (51%), Gaps = 41/474 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ +A +D + F + + TG+ ++L +PI + ++GV
Sbjct: 347 GLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFY 406
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G +L + YD++ + E + +A E+L E
Sbjct: 407 NRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEE 466
Query: 508 VQAMLLDKEPLNVDFADF-------------YLDP-------FRFDEFEKC-----KCII 542
++++L +E LNVD D DP FRF +F KC I
Sbjct: 467 IKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGI 526
Query: 543 SMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+F ++ + +F + LTR+ TV+K YR V YHN+ HG+ V M+ +L + +++
Sbjct: 527 RLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
Y + A+ A CHD+DHRG N Y ++ SPLA ++ +S LE HH + T+LQ
Sbjct: 587 -YTDLEA-FAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQD 644
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN-------LDKIRELYRSDEA-QFS 712
+ NIF +++ ++ ++ I+ATDLA +F +D ++ +EA ++
Sbjct: 645 ESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYV 704
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMM 771
DP+ +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMM
Sbjct: 705 TVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
DRNK +E P QVGF+ +C Y R PM + N WK+ AD+
Sbjct: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
Score = 85.0 bits (201), Expect = 1e-15
Identities = 61/185 (32%), Positives = 96/185 (51%), Gaps = 11/185 (5%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS--ELVSTVFDL- 369
S L+++ + EE + +Q + R L+ L+ ADR S+FL RN E+ S + D+
Sbjct: 59 SALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVT 118
Query: 370 ---KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
KFE +L KE+ P++ GI G A + +T N+PD + F+ +D+ TGY T
Sbjct: 119 PTSKFED--NLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG--LALHH-ARLYDRI 483
++L PI V +V+ V+ VNK + F DE F + F L LHH + +Y+
Sbjct: 177 KNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
Query: 484 MRKEQ 488
R+ Q
Sbjct: 237 SRRSQ 241
>AL157396-4|CAH73839.1| 858|Homo sapiens phosphodiesterase 6C,
cGMP-specific, cone, alpha prime protein.
Length = 858
Score = 246 bits (601), Expect = 4e-64
Identities = 152/474 (32%), Positives = 246/474 (51%), Gaps = 41/474 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ +A +D + F + + TG+ ++L +PI + ++GV
Sbjct: 347 GLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFY 406
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G +L + YD++ + E + +A E+L E
Sbjct: 407 NRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEE 466
Query: 508 VQAMLLDKEPLNVDFADF-------------YLDP-------FRFDEFEKC-----KCII 542
++++L +E LNVD D DP FRF +F KC I
Sbjct: 467 IKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGI 526
Query: 543 SMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+F ++ + +F + LTR+ TV+K YR V YHN+ HG+ V M+ +L + +++
Sbjct: 527 RLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
Y + A+ A CHD+DHRG N Y ++ SPLA ++ +S LE HH + T+LQ
Sbjct: 587 -YTDLEA-FAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQD 644
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN-------LDKIRELYRSDEA-QFS 712
+ NIF +++ ++ ++ I+ATDLA +F +D ++ +EA ++
Sbjct: 645 ESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYV 704
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMM 771
DP+ +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMM
Sbjct: 705 TVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
DRNK +E P QVGF+ +C Y R PM + N WK+ AD+
Sbjct: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
Score = 85.0 bits (201), Expect = 1e-15
Identities = 61/185 (32%), Positives = 96/185 (51%), Gaps = 11/185 (5%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNS--ELVSTVFDL- 369
S L+++ + EE + +Q + R L+ L+ ADR S+FL RN E+ S + D+
Sbjct: 59 SALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVT 118
Query: 370 ---KFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
KFE +L KE+ P++ GI G A + +T N+PD + F+ +D+ TGY T
Sbjct: 119 PTSKFED--NLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG--LALHH-ARLYDRI 483
++L PI V +V+ V+ VNK + F DE F + F L LHH + +Y+
Sbjct: 177 KNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
Query: 484 MRKEQ 488
R+ Q
Sbjct: 237 SRRSQ 241
>X90587-1|CAA62215.1| 617|Homo sapiens Rod cGMP phosphodiesterase
protein.
Length = 617
Score = 245 bits (599), Expect = 7e-64
Identities = 148/473 (31%), Positives = 242/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI +A +D ++F + +G+ ++L MPI + +++GV
Sbjct: 106 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 165
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 166 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 225
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 226 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 285
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 286 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 344
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 345 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 403
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ ++ ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 404 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 463
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 464 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 523
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 524 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 576
>X66142-1|CAA46932.1| 854|Homo sapiens 3',5'-cyclic-nucleotide
phosphodiesterase protein.
Length = 854
Score = 245 bits (599), Expect = 7e-64
Identities = 148/473 (31%), Positives = 242/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI +A +D ++F + +G+ ++L MPI + +++GV
Sbjct: 343 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 402
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 403 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 462
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 463 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 522
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 523 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 581
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 582 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 640
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ ++ ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 641 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 700
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 701 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 760
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 761 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813
Score = 82.2 bits (194), Expect = 8e-15
Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 8/172 (4%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S LL++V+ + +E +++++++ ++L L+ ADR SLF+ RN +EL + +F ++
Sbjct: 56 STALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQ 114
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L EI P++ G+ GHVA + + +N+ D F+ DE T YKT +
Sbjct: 115 PDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKN 174
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+L PI V+ V+ VNK + +F +DE ++F + A + ++Y
Sbjct: 175 MLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE---DVFLKYLNFATLYLKIY 223
>U31973-1|AAA96392.1| 858|Homo sapiens phosphodiesterase A' subunit
protein.
Length = 858
Score = 245 bits (599), Expect = 7e-64
Identities = 152/474 (32%), Positives = 246/474 (51%), Gaps = 41/474 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G N+ +A +D + F + + TG+ ++L +PI + ++GV
Sbjct: 347 GLPTYVAENGFICNMMNAPADEYFTFPKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFY 406
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G +L + YD++ + E + +A E+L E
Sbjct: 407 NRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATLEE 466
Query: 508 VQAMLLDKEPLNVDFADF-------------YLDP-------FRFDEFEKC-----KCII 542
++++L +E LNVD D DP FRF +F KC I
Sbjct: 467 IKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGI 526
Query: 543 SMFRDLFDMTQFDITT--LTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERF 600
+F ++ + +F + LTR+ TV+K YR V YHN+ HG+ V M+ +L + +++
Sbjct: 527 RLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWQHGFNVGQTMFTLLMTGRLKKY 586
Query: 601 DYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQ 660
Y + A+ A CHD+DHRG N Y ++ SPLA ++ +S LE HH + T+LQ
Sbjct: 587 -YTDLEA-FAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQD 644
Query: 661 DGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN-------LDKIRELYRSDEA-QFS 712
+ NIF +++ ++ ++ I+ATDLA +F +D ++ +EA ++
Sbjct: 645 ESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYV 704
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMM 771
DP+ +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMM
Sbjct: 705 TVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
Query: 772 DRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
DRNK +E P QVGF+ +C Y R PM + N WK+ AD+
Sbjct: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
Score = 81.8 bits (193), Expect = 1e-14
Identities = 60/185 (32%), Positives = 93/185 (50%), Gaps = 11/185 (5%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN------SELVSTV 366
S L+++ + EE + +Q + R L+ L+ ADR S+FL RN S L+
Sbjct: 59 SALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLVVT 118
Query: 367 FDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKT 426
KFE +L KE+ P++ GI G A + +T N+PD + F+ +D+ TGY T
Sbjct: 119 PTSKFED--NLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176
Query: 427 ISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFG--LALHH-ARLYDRI 483
++L PI V +V+ V+ VNK + F DE F + F L LHH + +Y+
Sbjct: 177 KNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
Query: 484 MRKEQ 488
R+ Q
Sbjct: 237 SRRSQ 241
>S41458-1|AAB22690.1| 854|Homo sapiens rod cGMP phosphodiesterase
beta-subunit protein.
Length = 854
Score = 245 bits (599), Expect = 7e-64
Identities = 148/473 (31%), Positives = 242/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI +A +D ++F + +G+ ++L MPI + +++GV
Sbjct: 343 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 402
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 403 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 462
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 463 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 522
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 523 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 581
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 582 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 640
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ ++ ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 641 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 700
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 701 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 760
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 761 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813
Score = 82.2 bits (194), Expect = 8e-15
Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 8/172 (4%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S LL++V+ + +E +++++++ ++L L+ ADR SLF+ RN +EL + +F ++
Sbjct: 56 STALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQ 114
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L EI P++ G+ GHVA + + +N+ D F+ DE T YKT +
Sbjct: 115 PDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKN 174
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+L PI V+ V+ VNK + +F +DE ++F + A + ++Y
Sbjct: 175 MLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE---DVFLKYLNFATLYLKIY 223
>BT009794-1|AAP88796.1| 853|Homo sapiens phosphodiesterase 6B,
cGMP-specific, rod, beta (congenital stationary night
bli protein.
Length = 853
Score = 244 bits (597), Expect = 1e-63
Identities = 148/473 (31%), Positives = 241/473 (50%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI +A +D ++F + +G+ ++L MPI + +++GV
Sbjct: 343 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 402
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 403 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 462
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 463 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 522
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 523 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 581
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 582 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 640
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ + ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 641 TLNIYQNLNRRQHDHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 700
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 701 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 760
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 761 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813
Score = 82.2 bits (194), Expect = 8e-15
Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 8/172 (4%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S LL++V+ + +E +++++++ ++L L+ ADR SLF+ RN +EL + +F ++
Sbjct: 56 STALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQ 114
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L EI P++ G+ GHVA + + +N+ D F+ DE T YKT +
Sbjct: 115 PDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKN 174
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+L PI V+ V+ VNK + +F +DE ++F + A + ++Y
Sbjct: 175 MLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE---DVFLKYLNFATLYLKIY 223
>BC000249-1|AAH00249.1| 853|Homo sapiens phosphodiesterase 6B,
cGMP-specific, rod, beta (congenital stationary night
bli protein.
Length = 853
Score = 244 bits (597), Expect = 1e-63
Identities = 148/473 (31%), Positives = 241/473 (50%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI +A +D ++F + +G+ ++L MPI + +++GV
Sbjct: 343 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 402
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 403 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 462
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 463 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 522
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 523 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 581
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 582 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 640
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ + ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 641 TLNIYQNLNRRQHDHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 700
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 701 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 760
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 761 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813
Score = 82.2 bits (194), Expect = 8e-15
Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 8/172 (4%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S LL++V+ + +E +++++++ ++L L+ ADR SLF+ RN +EL + +F ++
Sbjct: 56 STALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQ 114
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L EI P++ G+ GHVA + + +N+ D F+ DE T YKT +
Sbjct: 115 PDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKN 174
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+L PI V+ V+ VNK + +F +DE ++F + A + ++Y
Sbjct: 175 MLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE---DVFLKYLNFATLYLKIY 223
>X62692-1|CAA44569.1| 854|Homo sapiens cGMP phosphodiesterase beta
subunit protein.
Length = 854
Score = 243 bits (594), Expect = 3e-63
Identities = 147/473 (31%), Positives = 241/473 (50%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA SG NI + +D ++F + +G+ ++L MPI + +++GV
Sbjct: 343 GLPSYVAESGFICNIMNRSADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 402
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + YD++ + E + +A +++ YH C E
Sbjct: 403 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 462
Query: 508 VQAML-----LDKEPLNVD-------------------FADFYLDPFRFDEFEKCKCIIS 543
+Q +L L KEP + D +F+ E + KC I
Sbjct: 463 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 522
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ VA M+ +L + + +
Sbjct: 523 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSY- 581
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y + A+ A LCHD+DHRG N Y ++ +PLA ++ +S LE HH +L ++
Sbjct: 582 YTDLEA-FAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEE 640
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NI+ +++ ++ ++ + I+ATDLA +F KI + ++ + + SW
Sbjct: 641 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEILS 700
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q K ++ EF++QGD ER + PIPMMD
Sbjct: 701 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 760
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK E P QVGF+ +C Y R PM+ N WKA AD+
Sbjct: 761 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813
Score = 82.2 bits (194), Expect = 8e-15
Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 8/172 (4%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S LL++V+ + +E +++++++ ++L L+ ADR SLF+ RN +EL + +F ++
Sbjct: 56 STALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQ 114
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L EI P++ G+ GHVA + + +N+ D F+ DE T YKT +
Sbjct: 115 PDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKN 174
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLY 480
+L PI V+ V+ VNK + +F +DE ++F + A + ++Y
Sbjct: 175 MLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE---DVFLKYLNFATLYLKIY 223
>M26061-1|AAB69155.1| 860|Homo sapiens PDEA protein.
Length = 860
Score = 241 bits (589), Expect = 1e-62
Identities = 148/473 (31%), Positives = 243/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G NI +A ++ + F ++ + +G+ ++L MPI + +++GV
Sbjct: 345 GLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFY 404
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + Y+ + + E + + +++ YH C E
Sbjct: 405 NRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEE 464
Query: 508 VQAML-----LDKEP-----------LNVDFAD---FYLDPFRFD-----EFEKCKCIIS 543
+Q +L KEP L + D + ++ F F E E KC I
Sbjct: 465 IQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQ 524
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ V M+++L + +R
Sbjct: 525 MYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKR-- 582
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y LA+ A CHD+DHRG N Y ++ +PLA ++ +S LE HH T+L+ +
Sbjct: 583 YFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDE 642
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NIF +++ ++ + + I+ATDLA +F KI + ++ E++ W
Sbjct: 643 SLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMM 702
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMMD
Sbjct: 703 LEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMD 762
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK +E P QVGF+ +C Y R PM T N WKA AD+
Sbjct: 763 RNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADE 815
Score = 82.2 bits (194), Expect = 8e-15
Identities = 54/166 (32%), Positives = 88/166 (53%), Gaps = 5/166 (3%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S+ + D+++ F+E + ++ I +++ L+ ADR SLF+ RN +EL + +F++
Sbjct: 58 SEIIFDLLRD-FQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVH 116
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L M +EI P++ GI GHVA S + N+P+ D F VD T YKT +
Sbjct: 117 KDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKN 176
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLAL 474
IL PI V+ ++ VNK D +F DE + F L +
Sbjct: 177 ILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM 222
>BC035909-1|AAH35909.1| 860|Homo sapiens phosphodiesterase 6A,
cGMP-specific, rod, alpha protein.
Length = 860
Score = 241 bits (589), Expect = 1e-62
Identities = 148/473 (31%), Positives = 243/473 (51%), Gaps = 40/473 (8%)
Query: 391 GIAGHVALSGETMNIPDAYSD--YRFNRDVDEATGYKTISILCMPI-KVEGKVIGVVQMV 447
G+ +VA +G NI +A ++ + F ++ + +G+ ++L MPI + +++GV
Sbjct: 345 GLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFY 404
Query: 448 NKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYE 507
N++D K F + DE E + F G ++ + Y+ + + E + + +++ YH C E
Sbjct: 405 NRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEE 464
Query: 508 VQAML-----LDKEP-----------LNVDFAD---FYLDPFRFD-----EFEKCKCIIS 543
+Q +L KEP L + D + ++ F F E E KC I
Sbjct: 465 IQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQ 524
Query: 544 MFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFD 601
M+ +L + +F I L RF ++ K YR + YHN+ HG+ V M+++L + +R
Sbjct: 525 MYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKR-- 582
Query: 602 YNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQD 661
Y LA+ A CHD+DHRG N Y ++ +PLA ++ +S LE HH T+L+ +
Sbjct: 583 YFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDE 642
Query: 662 GHNIFSHISSEDYKEILGFIRHCILATDLAAFFPN---LDKIRELYRSDEAQFSWD---- 714
NIF +++ ++ + + I+ATDLA +F KI + ++ E++ W
Sbjct: 643 SLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMM 702
Query: 715 -DPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA-GRIPIPMMD 772
+ + +++ MA+ MTA DLSA KPWE+Q + ++ EF++QGD ER + PIPMMD
Sbjct: 703 LEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMD 762
Query: 773 RNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADK 825
RNK +E P QVGF+ +C Y R PM T N WKA AD+
Sbjct: 763 RNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADE 815
Score = 82.2 bits (194), Expect = 8e-15
Identities = 54/166 (32%), Positives = 88/166 (53%), Gaps = 5/166 (3%)
Query: 313 SDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRN--SELVSTVFDLK 370
S+ + D+++ F+E + ++ I +++ L+ ADR SLF+ RN +EL + +F++
Sbjct: 58 SEIIFDLLRD-FQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVH 116
Query: 371 FEPGLD--LDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTIS 428
+ L+ L M +EI P++ GI GHVA S + N+P+ D F VD T YKT +
Sbjct: 117 KDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKN 176
Query: 429 ILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLAL 474
IL PI V+ ++ VNK D +F DE + F L +
Sbjct: 177 ILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM 222
>AC093752-1|AAY40985.1| 331|Homo sapiens unknown protein.
Length = 331
Score = 224 bits (548), Expect = 1e-57
Identities = 123/308 (39%), Positives = 174/308 (56%), Gaps = 12/308 (3%)
Query: 524 DFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYR-TVPYHNFDH 580
DF F + E C I MF DL + F + L R+ L+VKKNYR V YHN+ H
Sbjct: 14 DFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRH 73
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSR--LALFVACLCHDLDHRGYTNKYMSETASPLA 638
+ A M+A LK+ + NK + LAL +A L HDLDHRG N Y+ + PLA
Sbjct: 74 AFNTAQCMFAALKAGKIQ----NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLA 129
Query: 639 AMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLD 698
+Y S +EHHHF+ + IL G+ I S +S E+YK L I+ ILATDLA +
Sbjct: 130 QLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRG 189
Query: 699 KIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGD 758
+ EL R + QF+ +DP ++L +A+ MTA DLSA KPW IQ + +++ EF+DQGD
Sbjct: 190 EFFELIRKN--QFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGD 247
Query: 759 KERAAGRI-PIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLN 817
+ER I P +M+R K + P+ QVGF+ IC+ Y+ L + + P+ KN
Sbjct: 248 RERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQ 307
Query: 818 RWKARADK 825
+W+A A++
Sbjct: 308 KWQALAEQ 315
>BT007016-1|AAP35662.1| 533|Homo sapiens phosphodiesterase 9A
protein.
Length = 533
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 202 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 261
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 262 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 318
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 319 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 378
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 379 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 434
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 435 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 473
>BC009047-1|AAH09047.1| 533|Homo sapiens phosphodiesterase 9A
protein.
Length = 533
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 202 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 261
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 262 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 318
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 319 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 378
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 379 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 434
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 435 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 473
>AY701187-1|AAV84271.1| 485|Homo sapiens phosphodiesterase PDE9A21
protein.
Length = 485
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 154 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 213
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 214 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 270
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 271 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 330
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 331 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 386
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 387 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 425
>AY242121-1|AAO88210.1| 492|Homo sapiens type 9 cGMP-specific
phosphodiesterase isoform 5 protein.
Length = 492
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 161 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 220
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 221 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 277
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 278 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 337
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 338 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 393
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 394 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 432
>AY196314-1|AAO34700.1| 386|Homo sapiens phosphodiesterase PDE9A20
protein.
Length = 386
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 55 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 232 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 288 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 326
>AY196313-1|AAO34699.1| 386|Homo sapiens phosphodiesterase PDE9A19
protein.
Length = 386
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 55 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 232 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 288 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 326
>AY196312-1|AAO34698.1| 567|Homo sapiens phosphodiesterase PDE9A18
protein.
Length = 567
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 236 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 295
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 296 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 352
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 353 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 412
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 413 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 468
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 469 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 507
>AY196311-1|AAO34697.1| 552|Homo sapiens phosphodiesterase PDE9A17
protein.
Length = 552
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 221 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 280
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 281 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 337
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 338 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 397
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 398 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 453
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 454 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 492
>AY196310-1|AAO34696.1| 526|Homo sapiens phosphodiesterase PDE9A16
protein.
Length = 526
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 195 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 254
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 255 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 311
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 312 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 371
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 372 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 427
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 428 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 466
>AY196309-1|AAO34695.1| 376|Homo sapiens phosphodiesterase PDE9A15
protein.
Length = 376
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 45 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 104
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 105 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 161
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 162 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 221
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 222 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 277
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 278 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 316
>AY196308-1|AAO34694.1| 386|Homo sapiens phosphodiesterase PDE9A14
protein.
Length = 386
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 55 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 232 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 288 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 326
>AY196307-1|AAO34693.1| 491|Homo sapiens phosphodiesterase PDE9A13
protein.
Length = 491
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 160 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 219
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 220 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 276
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 277 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 336
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 337 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 392
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 393 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 431
>AY196306-1|AAO34692.1| 459|Homo sapiens phosphodiesterase PDE9A12
protein.
Length = 459
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 128 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 187
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 188 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 244
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 245 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 304
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 305 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 360
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 361 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 399
>AY196305-1|AAO34691.1| 376|Homo sapiens phosphodiesterase PDE9A11
protein.
Length = 376
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 45 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 104
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 105 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 161
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 162 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 221
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 222 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 277
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 278 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 316
>AY196304-1|AAO34690.1| 433|Homo sapiens phosphodiesterase PDE9A10
protein.
Length = 433
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 102 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 161
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 162 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 218
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 219 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 278
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 279 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 334
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 335 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 373
>AY196303-1|AAO34689.1| 507|Homo sapiens phosphodiesterase PDE9A9
protein.
Length = 507
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 176 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 235
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 236 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 292
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 293 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 352
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 353 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 408
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 409 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 447
>AY196302-1|AAO34688.1| 386|Homo sapiens phosphodiesterase PDE9A8
protein.
Length = 386
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 55 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 232 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 288 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 326
>AY196301-1|AAO34687.1| 386|Homo sapiens phosphodiesterase PDE9A7
protein.
Length = 386
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 55 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 114
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 115 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 232 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 287
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 288 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 326
>AY196300-1|AAO34686.1| 492|Homo sapiens phosphodiesterase PDE9A6
protein.
Length = 492
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 161 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 220
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 221 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 277
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 278 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 337
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 338 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 393
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 394 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 432
>AY196299-1|AAO34685.1| 540|Homo sapiens phosphodiesterase PDE9A5
protein.
Length = 540
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 209 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 268
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 269 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 325
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 326 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 385
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 386 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 441
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 442 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 480
>AP001747-1|BAA95552.1| 593|Homo sapiens CGMP-specific 3',5'-cyclic
phosphodiesterase type 9, EC 3.1.4.17. protein.
Length = 593
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 262 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 321
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 322 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 378
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 379 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 438
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 439 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 494
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 495 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 533
>AF067226-1|AAC26726.1| 465|Homo sapiens cGMP phosphodiesterase A4
protein.
Length = 465
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 134 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 193
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 194 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 250
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 251 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 310
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 311 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 366
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 367 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 405
>AF067225-1|AAC26725.1| 466|Homo sapiens cGMP phosphodiesterase A3
protein.
Length = 466
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 135 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 194
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 195 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 251
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 252 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 311
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 312 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 367
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 368 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 406
>AF067224-1|AAC26724.1| 533|Homo sapiens cGMP phosphodiesterase A2
protein.
Length = 533
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 202 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 261
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 262 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 318
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 319 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 378
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 379 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 434
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 435 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 473
>AF067223-1|AAC26723.1| 593|Homo sapiens cGMP phosphodiesterase A1
protein.
Length = 593
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 262 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 321
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 322 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 378
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 379 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 438
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 439 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 494
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 495 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 533
>AF048837-1|AAC39778.1| 593|Homo sapiens cGMP-specific
phosphodiesterase protein.
Length = 593
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 262 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 321
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 322 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 378
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 379 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 438
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 439 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 494
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 495 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 533
>AB017602-1|BAA88847.1| 593|Homo sapiens cGMP phosphodiesterase
protein.
Length = 593
Score = 152 bits (369), Expect = 5e-36
Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 12/280 (4%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMTQFDIT--TLTRFTLTVKKNYRTVPYHNFDHGWTVA 585
D + ++ E C+ M+ DL + F I TL R+ V NYR P+HNF H + VA
Sbjct: 262 DVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVA 321
Query: 586 HAMYAIL-KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT- 643
MY+++ ++E+F L L A +CHDLDH GY N Y + LA Y
Sbjct: 322 QMMYSMVWLCSLQEKFSQTDI---LILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 378
Query: 644 STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIREL 703
S LE+HH + IL + NIFS+I + +K+I + ILATD+A +D +E
Sbjct: 379 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 438
Query: 704 YRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAA 763
+ F + + H L I + D+S +P E+ V + EE++ Q D+E++
Sbjct: 439 MEN----FDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 494
Query: 764 GRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILP 803
G P MDR+K + A Q+GF+ + IP ++ + ++ P
Sbjct: 495 GLPVAPFMDRDKVTKATA-QIGFIKFVLIPMFETVTKLFP 533
>AY266363-1|AAP31235.1| 255|Homo sapiens phosphodiesterase isozyme
5 protein.
Length = 255
Score = 124 bits (299), Expect = 1e-27
Identities = 73/172 (42%), Positives = 105/172 (61%), Gaps = 7/172 (4%)
Query: 333 LIKRILEFAQRLVNADRASLFLV--DYRNSE-LVSTVFDLKFEPGLDLDMEKKEIRMPIN 389
L +I L++ADR SLFLV D N + L+S +FD+ L+ ++ IR+ N
Sbjct: 12 LCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLE-EVSNNCIRLEWN 70
Query: 390 RGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIK-VEGKVIGVVQMVN 448
+GI GHVA GE +NI DAY D RFN +VD+ TGYKT SILCMPIK +V+GV Q +N
Sbjct: 71 KGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAIN 130
Query: 449 KRDDK--YFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLS 498
K+ F + DE F + F G+ LH+A+LY+ + + ++ +V L++ S
Sbjct: 131 KKSGNGGTFTEKDEKDFAAYLAFGGIVLHNAQLYETSLLENKRNQVLLDLAS 182
Score = 50.0 bits (114), Expect = 4e-05
Identities = 26/91 (28%), Positives = 46/91 (50%)
Query: 282 DEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFA 341
DE+ + +G + LH +LY E + LLD+ IFEE SL+ ++K+I
Sbjct: 143 DEKDFAAYLAFGGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATI 202
Query: 342 QRLVNADRASLFLVDYRNSELVSTVFDLKFE 372
+ + ++F+VD S+ +VF ++ E
Sbjct: 203 ISFMQVQKCTIFIVDEDCSDSFFSVFHMECE 233
>U97584-1|AAC25679.1| 647|Homo sapiens cyclic AMP-specific
phosphodiesterase HSPDE4A1A protein.
Length = 647
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 154 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 213
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 214 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 271
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 272 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 331
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 332 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 391
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 392 CDKHTASVE-KSQVGFIDYIVHPLWE 416
>U68532-1|AAC63832.1| 647|Homo sapiens cyclic AMP specific
phosphodiesterase RD1 protein.
Length = 647
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 154 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 213
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 214 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 271
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 272 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 331
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 332 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 391
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 392 CDKHTASVE-KSQVGFIDYIVHPLWE 416
>U18087-1|AAC50458.1| 686|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase HPDE4A6 protein.
Length = 686
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 193 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 252
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 253 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 310
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 311 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 370
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 371 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 430
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 431 CDKHTASVE-KSQVGFIDYIVHPLWE 455
>S75213-1|AAB33798.1| 667|Homo sapiens type-IVA cyclic AMP specific
phosphodiesterase protein.
Length = 667
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 174 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 233
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 234 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 291
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 292 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 351
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 352 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 411
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 412 CDKHTASVE-KSQVGFIDYIVHPLWE 436
>M37744-1|AAA69697.1| 775|Homo sapiens protein ( Human cyclic AMP
(cAMP)-specific phosphodiesterase mRNA, complete cds. ).
Length = 775
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 282 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 341
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 342 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 399
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 400 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 459
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 460 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 519
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 520 CDKHTASVE-KSQVGFIDYIVHPLWE 544
>L20965-1|AAA03588.1| 886|Homo sapiens phosphodiesterase protein.
Length = 886
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 393 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 452
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 453 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 510
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 511 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 570
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 571 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 630
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 631 CDKHTASVE-KSQVGFIDYIVHPLWE 655
>BC038234-1|AAH38234.1| 647|Homo sapiens phosphodiesterase 4A,
cAMP-specific (phosphodiesterase E2 dunce homolog,
Drosop protein.
Length = 647
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 154 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 213
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 214 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 271
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 272 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 331
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 332 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 391
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 392 CDKHTASVE-KSQVGFIDYIVHPLWE 416
>BC019864-1|AAH19864.1| 647|Homo sapiens phosphodiesterase 4A,
cAMP-specific (phosphodiesterase E2 dunce homolog,
Drosop protein.
Length = 647
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 154 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 213
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 214 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 271
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 272 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 331
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 332 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 391
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 392 CDKHTASVE-KSQVGFIDYIVHPLWE 416
>AY618547-1|AAU82096.1| 860|Homo sapiens cyclic AMP
phosphodiesterase PDE4A11 protein.
Length = 860
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 367 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 426
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 427 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 484
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 485 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 544
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 545 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 604
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 605 CDKHTASVE-KSQVGFIDYIVHPLWE 629
>AY593872-1|AAT00628.1| 864|Homo sapiens cAMP-specific
phosphodiesterase protein.
Length = 864
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 371 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 430
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 431 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 488
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 489 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 548
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 549 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 608
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 609 CDKHTASVE-KSQVGFIDYIVHPLWE 633
>AF073745-1|AAD34217.2| 825|Homo sapiens cyclic AMP-specific
phosphodiesterase HSPDE4A10 protein.
Length = 825
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 332 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 391
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 392 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 449
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 450 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 509
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 510 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 569
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 570 CDKHTASVE-KSQVGFIDYIVHPLWE 594
>AF069491-3|AAC35013.1| 647|Homo sapiens cAMP specific
phosphodiesterase 4A variant RD1 protein.
Length = 647
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 154 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 213
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 214 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 271
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 272 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 331
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 332 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 391
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 392 CDKHTASVE-KSQVGFIDYIVHPLWE 416
>AF069491-2|AAC35015.1| 860|Homo sapiens putative novel cAMP
specific phosphodiesterase 4A variant protein.
Length = 860
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 367 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 426
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 427 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 484
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 485 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 544
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 545 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 604
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 605 CDKHTASVE-KSQVGFIDYIVHPLWE 629
>AF069491-1|AAC35012.1| 886|Homo sapiens cAMP specific
phosphodiesterase 4A variant pde46 protein.
Length = 886
Score = 117 bits (282), Expect = 2e-25
Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 393 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 452
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 453 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 510
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 511 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 570
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 571 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 630
Query: 771 MDRNKPEEQPASQVGFLSQICIPCYD 796
D++ + SQVGF+ I P ++
Sbjct: 631 CDKHTASVE-KSQVGFIDYIVHPLWE 655
>U02882-1|AAC13745.1| 604|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 604
Score = 115 bits (277), Expect = 7e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 226 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 284
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 285 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 343
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 344 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 403
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 404 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFPQGDRERERGMEISPMCDKHNASVE 463
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 464 -KSQVGFIDYIVHPLWE 479
>U50159-1|AAA97892.1| 673|Homo sapiens cAMP-specific
phoshodiesterase HPDE4D3 variant protein.
Length = 673
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 295 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 353
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 354 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 412
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 413 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 472
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 473 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 532
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 533 -KSQVGFIDYIVHPLWE 548
>U50158-1|AAA97891.1| 507|Homo sapiens cAMP-specific
phosphodiesterase HPDE4D2 variant protein.
Length = 507
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 129 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 187
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 188 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 246
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 247 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 306
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 307 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 366
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 367 -KSQVGFIDYIVHPLWE 382
>U50157-1|AAA97890.1| 585|Homo sapiens cAMP-specific
phosphodiesterase HPDE4D1 variant protein.
Length = 585
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 207 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 265
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 266 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 324
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 325 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 384
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 385 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 444
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 445 -KSQVGFIDYIVHPLWE 460
>L20970-1|AAA03592.1| 673|Homo sapiens phosphodiesterase protein.
Length = 673
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 295 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 353
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 354 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 412
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 413 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 472
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 473 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 532
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 533 -KSQVGFIDYIVHPLWE 548
>L20969-1|AAC00042.1| 809|Homo sapiens cyclic AMP phosphodiesterase
protein.
Length = 809
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 431 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 489
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 490 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 548
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 549 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 608
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 609 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 668
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 669 -KSQVGFIDYIVHPLWE 684
>AY388960-1|AAQ90404.1| 679|Homo sapiens cAMP-specific
phosphodiesterase PDE4D9 protein.
Length = 679
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 301 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 359
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 360 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 418
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 419 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 478
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 479 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 538
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 539 -KSQVGFIDYIVHPLWE 554
>AY245867-1|AAP75761.1| 679|Homo sapiens cAMP-specific
phosphodiesterase variant PDE4D9 protein.
Length = 679
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 301 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 359
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 360 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 418
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 419 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 478
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 479 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 538
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 539 -KSQVGFIDYIVHPLWE 554
>AY245866-1|AAP75760.1| 748|Homo sapiens cAMP-specific
phosphodiesterase variant PDE4D7 protein.
Length = 748
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 370 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 428
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 429 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 487
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 488 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 547
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 548 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 607
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 608 -KSQVGFIDYIVHPLWE 623
>AF536976-1|AAN10118.1| 748|Homo sapiens cAMP-specific
phosphodiesterase PDE4D7 protein.
Length = 748
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 370 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 428
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 429 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 487
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 488 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 547
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 548 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 607
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 608 -KSQVGFIDYIVHPLWE 623
>AF536975-1|AAN10117.1| 518|Homo sapiens cAMP-specific
phosphodiesterase PDE4D6 protein.
Length = 518
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 140 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 198
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 199 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 257
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 258 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 317
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 318 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 377
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 378 -KSQVGFIDYIVHPLWE 393
>AF012074-1|AAC00070.1| 507|Homo sapiens cAMP-specific
phosphodiesterase PDE4D2 protein.
Length = 507
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 129 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 187
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 188 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 246
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 247 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 306
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 307 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 366
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 367 -KSQVGFIDYIVHPLWE 382
>AF012073-1|AAC00069.1| 745|Homo sapiens cAMP-specific
phosphodiesterase PDE4D5 protein.
Length = 745
Score = 115 bits (276), Expect = 9e-25
Identities = 73/257 (28%), Positives = 129/257 (50%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 367 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 425
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 426 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 484
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 485 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 544
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 545 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 604
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 605 -KSQVGFIDYIVHPLWE 620
>U67932-1|AAB65772.1| 456|Homo sapiens cAMP phosphodiesterase PDE7
protein.
Length = 456
Score = 114 bits (275), Expect = 1e-24
Identities = 91/326 (27%), Positives = 155/326 (47%), Gaps = 24/326 (7%)
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ R +R + +R S + +Y QA + ++ N +F D F FD
Sbjct: 88 FQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNF-----DIFLFDRLTNGN 142
Query: 540 CIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL 592
++S+ LF + D+ L RF + ++++Y + PYHN H V AM+ L
Sbjct: 143 SLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYL 202
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHF 651
K + K L+L +A HDLDH G ++ +T LA +Y TS LE+HH+
Sbjct: 203 K-EPKLANSVTPWDILLSL-IAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 260
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS--DEA 709
V +L++ G +FSH+ E +++ I ILATD++ ++ L+RS D
Sbjct: 261 RSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS----RQNEYLSLFRSHLDRG 314
Query: 710 QFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP 769
+D HR L + +++ AD+ + WE+ + + + EEF+ QGD E+ P
Sbjct: 315 DLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 374
Query: 770 MMDRNKPEEQPASQVGFLSQICIPCY 795
+ DR+ E Q+GF++ + P +
Sbjct: 375 LCDRH-TESIANIQIGFMTYLVEPLF 399
>L12052-1|AAA35644.2| 482|Homo sapiens cAMP phosphodiesterase PDE7
protein.
Length = 482
Score = 114 bits (275), Expect = 1e-24
Identities = 91/326 (27%), Positives = 155/326 (47%), Gaps = 24/326 (7%)
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ R +R + +R S + +Y QA + ++ N +F D F FD
Sbjct: 114 FQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNF-----DIFLFDRLTNGN 168
Query: 540 CIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL 592
++S+ LF + D+ L RF + ++++Y + PYHN H V AM+ L
Sbjct: 169 SLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYL 228
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHF 651
K + K L+L +A HDLDH G ++ +T LA +Y TS LE+HH+
Sbjct: 229 K-EPKLANSVTPWDILLSL-IAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 286
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS--DEA 709
V +L++ G +FSH+ E +++ I ILATD++ ++ L+RS D
Sbjct: 287 RSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS----RQNEYLSLFRSHLDRG 340
Query: 710 QFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP 769
+D HR L + +++ AD+ + WE+ + + + EEF+ QGD E+ P
Sbjct: 341 DLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400
Query: 770 MMDRNKPEEQPASQVGFLSQICIPCY 795
+ DR+ E Q+GF++ + P +
Sbjct: 401 LCDRH-TESIANIQIGFMTYLVEPLF 425
>BC126360-1|AAI26361.1| 456|Homo sapiens phosphodiesterase 7A
protein.
Length = 456
Score = 114 bits (275), Expect = 1e-24
Identities = 91/326 (27%), Positives = 155/326 (47%), Gaps = 24/326 (7%)
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ R +R + +R S + +Y QA + ++ N +F D F FD
Sbjct: 88 FQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNF-----DIFLFDRLTNGN 142
Query: 540 CIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL 592
++S+ LF + D+ L RF + ++++Y + PYHN H V AM+ L
Sbjct: 143 SLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYL 202
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHF 651
K + K L+L +A HDLDH G ++ +T LA +Y TS LE+HH+
Sbjct: 203 K-EPKLANSVTPWDILLSL-IAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 260
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS--DEA 709
V +L++ G +FSH+ E +++ I ILATD++ ++ L+RS D
Sbjct: 261 RSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS----RQNEYLSLFRSHLDRG 314
Query: 710 QFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP 769
+D HR L + +++ AD+ + WE+ + + + EEF+ QGD E+ P
Sbjct: 315 DLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 374
Query: 770 MMDRNKPEEQPASQVGFLSQICIPCY 795
+ DR+ E Q+GF++ + P +
Sbjct: 375 LCDRH-TESIANIQIGFMTYLVEPLF 399
>AF536977-1|AAN10119.1| 687|Homo sapiens cAMP-specific
phosphodiesterase PDE4D8 protein.
Length = 687
Score = 114 bits (275), Expect = 1e-24
Identities = 73/257 (28%), Positives = 128/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 309 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 367
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G +N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 368 LEILAAIFASAI-HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 426
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 427 GIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 486
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 487 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 546
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 547 -KSQVGFIDYIVHPLWE 562
>U40370-1|AAC50436.1| 535|Homo sapiens 3',5' cyclic nucleotide
phosphodiesterase protein.
Length = 535
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 244
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 245 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 304
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 305 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 357
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 358 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 416
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 417 QIGFIDFIVEPTFSLL 432
>BC022480-1|AAH22480.1| 545|Homo sapiens phosphodiesterase 1A,
calmodulin-dependent protein.
Length = 545
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 244
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 245 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 304
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 305 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 357
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 358 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 416
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 417 QIGFIDFIVEPTFSLL 432
>AL110263-1|CAB53703.1| 519|Homo sapiens hypothetical protein
protein.
Length = 519
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 172 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 228
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 229 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 288
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 289 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 341
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 342 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 400
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 401 QIGFIDFIVEPTFSLL 416
>AJ401610-1|CAC82208.1| 519|Homo sapiens 3'5' cyclic nucleotide
phosphodiesterase 1A5 protein.
Length = 519
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 172 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 228
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 229 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 288
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 289 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 341
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 342 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 400
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 401 QIGFIDFIVEPTFSLL 416
>AB038224-9|BAB20054.1| 518|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 518
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 154 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 210
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 211 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 270
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 271 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 323
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 324 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 382
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 383 QIGFIDFIVEPTFSLL 398
>AB038224-8|BAB20053.1| 501|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 501
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 154 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 210
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 211 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 270
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 271 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 323
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 324 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 382
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 383 QIGFIDFIVEPTFSLL 398
>AB038224-7|BAB20057.1| 511|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 511
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 154 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 210
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 211 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 270
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 271 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 323
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 324 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 382
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 383 QIGFIDFIVEPTFSLL 398
>AB038224-6|BAB20052.1| 552|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 552
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 244
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 245 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 304
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 305 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 357
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 358 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 416
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 417 QIGFIDFIVEPTFSLL 432
>AB038224-5|BAB20050.1| 535|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 535
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 244
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 245 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 304
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 305 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 357
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 358 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 416
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 417 QIGFIDFIVEPTFSLL 432
>AB038224-4|BAB20056.1| 545|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 545
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 244
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 245 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 304
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 305 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 357
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 358 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 416
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 417 QIGFIDFIVEPTFSLL 432
>AB038224-3|BAB20051.1| 536|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 536
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 172 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 228
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 229 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 288
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 289 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 341
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 342 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 400
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 401 QIGFIDFIVEPTFSLL 416
>AB038224-2|BAB20049.1| 519|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 519
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 172 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 228
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 229 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 288
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 289 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 341
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 342 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 400
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 401 QIGFIDFIVEPTFSLL 416
>AB038224-1|BAB20055.1| 529|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 529
Score = 114 bits (274), Expect = 2e-24
Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 15/256 (5%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNYRTV--PYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + + ++ L F ++ Y PYHN H V + Y +L + + +
Sbjct: 172 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH---WL 228
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
LA+ A HD +H G TN + +T S +A +Y S LE+HH + ++Q++
Sbjct: 229 TELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEE 288
Query: 663 HNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLA 722
NI ++S +D++++ + +L+TD++ F + IR + E R
Sbjct: 289 MNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-------IDRAKT 341
Query: 723 MAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPAS 782
M++ + AAD+S AK W++ + + EEF+ QGDKE G P+ DR K S
Sbjct: 342 MSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQS 400
Query: 783 QVGFLSQICIPCYDML 798
Q+GF+ I P + +L
Sbjct: 401 QIGFIDFIVEPTFSLL 416
>BC036319-1|AAH36319.1| 518|Homo sapiens PDE4D protein protein.
Length = 518
Score = 113 bits (273), Expect = 2e-24
Identities = 73/257 (28%), Positives = 128/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + + TL + +T++ +Y V YHN H V + + +L + E +
Sbjct: 140 RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV-FTD 198
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F + + HD+DH G N+++ T S LA MY +S LE+HH + +LQ++
Sbjct: 199 LEILAAIFASAI-HDVDHPGVFNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC 257
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW----DDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ S R
Sbjct: 258 DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDR 317
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS KP ++ + I EEF+ QGD+ER G PM D++ +
Sbjct: 318 IQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE 377
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 378 -KSQVGFIDYIVHPLWE 393
>U88713-1|AAC51916.1| 700|Homo sapiens phosphodiesterase 4C
protein.
Length = 700
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 338 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 397
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 398 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 455
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 456 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 515
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 516 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 575
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 576 KHTASVE-KSQVGFIDYIAHPLWE 598
>U88712-1|AAC51915.1| 606|Homo sapiens phosphodiesterase 4C
protein.
Length = 606
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 244 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 303
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 304 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 482 KHTASVE-KSQVGFIDYIAHPLWE 504
>U66348-1|AAB96877.1| 518|Homo sapiens PDE4C-delta54 protein.
Length = 518
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 156 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 215
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 216 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 273
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 274 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 333
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 334 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 393
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 394 KHTASVE-KSQVGFIDYIAHPLWE 416
>U66347-1|AAB96876.1| 426|Homo sapiens PDE4C-426 protein.
Length = 426
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 64 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 123
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 124 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 181
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 182 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 241
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 242 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 301
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 302 KHTASVE-KSQVGFIDYIAHPLWE 324
>U66346-1|AAB96875.1| 791|Homo sapiens PDE4C-791 protein.
Length = 791
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 429 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 488
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 489 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 546
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 547 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 606
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 607 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 666
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 667 KHTASVE-KSQVGFIDYIAHPLWE 689
>BC109068-1|AAI09069.1| 549|Homo sapiens PDE4C protein protein.
Length = 549
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 187 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 246
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 247 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 304
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 305 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 364
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 365 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 424
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 425 KHTASVE-KSQVGFIDYIAHPLWE 447
>BC109067-1|AAI09068.1| 481|Homo sapiens PDE4C protein protein.
Length = 481
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 119 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 178
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 179 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 236
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 237 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 296
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 297 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 356
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 357 KHTASVE-KSQVGFIDYIAHPLWE 379
>AF157816-3|AAD47055.1| 606|Homo sapiens cAMP specific
phosphodiesterase PDE4C2 variant protein.
Length = 606
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 244 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 303
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 304 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 482 KHTASVE-KSQVGFIDYIAHPLWE 504
>AF157816-2|AAD47054.1| 680|Homo sapiens cAMP specific
phosphodiesterase PDE4C3 variant protein.
Length = 680
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 318 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 377
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 378 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 435
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 436 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 495
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 496 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 555
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 556 KHTASVE-KSQVGFIDYIAHPLWE 578
>AF157816-1|AAD47053.1| 712|Homo sapiens cAMP specific
phosphodiesterase PDE4C1 variant protein.
Length = 712
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 350 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 409
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 410 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 467
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 468 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 527
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 528 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 587
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 588 KHTASVE-KSQVGFIDYIAHPLWE 610
>AC005759-5|AAC83049.1| 426|Homo sapiens PDE4C-426 protein.
Length = 426
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 64 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 123
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 124 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 181
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 182 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 241
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 242 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 301
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 302 KHTASVE-KSQVGFIDYIAHPLWE 324
>AC005759-3|AAC83051.1| 518|Homo sapiens PDE4C-delta54 protein.
Length = 518
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 156 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 215
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 216 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 273
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 274 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 333
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 334 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 393
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 394 KHTASVE-KSQVGFIDYIAHPLWE 416
>AC005759-1|AAC83050.1| 782|Homo sapiens PDE4C-791 protein.
Length = 782
Score = 110 bits (265), Expect = 2e-23
Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 420 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 479
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 480 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 537
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 538 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 597
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 598 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 657
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 658 KHTASVE-KSQVGFIDYIAHPLWE 680
>U85048-1|AAB96381.1| 721|Homo sapiens cyclic AMP specific
phosphodiesterase protein.
Length = 721
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 360 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 418
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 419 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 477
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 478 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 537
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 538 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 597
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 598 -KSQVGFIDYIVHPLWE 613
>M97515-1|AAA36426.1| 564|Homo sapiens phosphodiesterase protein.
Length = 564
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 203 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 261
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 262 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 320
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 321 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 380
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 381 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 440
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 441 -KSQVGFIDYIVHPLWE 456
>L20971-1|AAA03593.1| 564|Homo sapiens phosphodiesterase protein.
Length = 564
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 203 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 261
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 262 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 320
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 321 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 380
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 381 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 440
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 441 -KSQVGFIDYIVHPLWE 456
>L20966-1|AAA03589.1| 736|Homo sapiens phosphodiesterase protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>L12686-1|AAA35643.1| 606|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 606
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 245 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 303
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 304 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 362
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 363 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 422
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 423 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 482
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 483 -KSQVGFIDYIVHPLWE 498
>BC105040-1|AAI05041.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>BC101480-1|AAI01481.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>AL592285-3|CAH70628.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 360 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 418
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 419 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 477
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 478 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 537
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 538 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 597
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 598 -KSQVGFIDYIVHPLWE 613
>AL592285-1|CAH70626.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>AL359701-3|CAI23101.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 360 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 418
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 419 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 477
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 478 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 537
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 538 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 597
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 598 -KSQVGFIDYIVHPLWE 613
>AL359701-2|CAI23100.1| 564|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 564
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 203 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 261
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 262 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 320
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 321 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 380
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 381 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 440
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 441 -KSQVGFIDYIVHPLWE 456
>AL359701-1|CAI23099.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>AL357273-3|CAH73004.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 360 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 418
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 419 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 477
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 478 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 537
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 538 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 597
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 598 -KSQVGFIDYIVHPLWE 613
>AL357273-1|CAH73002.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>AL109926-4|CAI21751.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 360 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 418
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 419 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 477
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 478 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 537
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 538 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 597
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 598 -KSQVGFIDYIVHPLWE 613
>AL109926-3|CAI21750.1| 564|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 564
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 203 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 261
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 262 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 320
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 321 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 380
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 381 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 440
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 441 -KSQVGFIDYIVHPLWE 456
>AL109926-2|CAI21749.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 375 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 433
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 434 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 492
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 493 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 552
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 553 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 612
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 613 -KSQVGFIDYIVHPLWE 628
>AB209081-1|BAD92318.1| 726|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 726
Score = 110 bits (264), Expect = 3e-23
Identities = 73/257 (28%), Positives = 127/257 (49%), Gaps = 9/257 (3%)
Query: 546 RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVKERFDYNK 604
RDL + T + +T++ +Y + V YHN H VA + + +L + + +
Sbjct: 365 RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV-FTD 423
Query: 605 ASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH 663
A+F A + HD+DH G +N+++ T S LA MY S LE+HH + +LQ++
Sbjct: 424 LEILAAIFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHC 482
Query: 664 NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFS----WDDPSHR 719
+IF +++ + + + + +LATD++ L ++ + + + S D+ + R
Sbjct: 483 DIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDR 542
Query: 720 DLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQ 779
+ + ADLS K E+ + I EEF+ QGDKER G PM D++ +
Sbjct: 543 IQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVE 602
Query: 780 PASQVGFLSQICIPCYD 796
SQVGF+ I P ++
Sbjct: 603 -KSQVGFIDYIVHPLWE 618
>Z46632-1|CAA86601.1| 712|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 712
Score = 109 bits (262), Expect = 4e-23
Identities = 77/264 (29%), Positives = 128/264 (48%), Gaps = 11/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 350 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 409
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T S +A MY S LE+HH +
Sbjct: 410 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTNSDVALMYNDASVLENHHLAVGFK 467
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 468 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 527
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 528 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 587
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 588 KHTASVE-KSQVGFIDYIAHPLWE 610
>AF332652-1|AAK57640.1| 424|Homo sapiens cAMP-specific cyclic
nucleotide phosphodiesterase PDE7A3 protein.
Length = 424
Score = 109 bits (261), Expect = 6e-23
Identities = 86/305 (28%), Positives = 145/305 (47%), Gaps = 23/305 (7%)
Query: 480 YDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCK 539
+ R +R + +R S + +Y QA + ++ N +F D F FD
Sbjct: 114 FQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNF-----DIFLFDRLTNGN 168
Query: 540 CIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL 592
++S+ LF + D+ L RF + ++++Y + PYHN H V AM+ L
Sbjct: 169 SLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYL 228
Query: 593 KSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMY-TTSTLEHHHF 651
K + K L+L +A HDLDH G ++ +T LA +Y TS LE+HH+
Sbjct: 229 K-EPKLANSVTPWDILLSL-IAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 286
Query: 652 NITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRS--DEA 709
V +L++ G +FSH+ E +++ I ILATD++ ++ L+RS D
Sbjct: 287 RSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS----RQNEYLSLFRSHLDRG 340
Query: 710 QFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIP 769
+D HR L + +++ AD+ + WE+ + + + EEF+ QGD E+ P
Sbjct: 341 DLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400
Query: 770 MMDRN 774
+ DR+
Sbjct: 401 LCDRH 405
>U18088-1|AAA98540.1| 323|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase HSPDE4A7A protein.
Length = 323
Score = 108 bits (260), Expect = 8e-23
Identities = 72/244 (29%), Positives = 119/244 (48%), Gaps = 11/244 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 59 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 118
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 119 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 176
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 177 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 236
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 237 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 296
Query: 771 MDRN 774
D++
Sbjct: 297 CDKH 300
>AF069491-4|AAC35014.1| 323|Homo sapiens cAMP specific
phosphodiesterase 4A variant 2EL protein.
Length = 323
Score = 108 bits (260), Expect = 8e-23
Identities = 72/244 (29%), Positives = 119/244 (48%), Gaps = 11/244 (4%)
Query: 540 CIISMF---RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSD 595
CI+ M RDL + + T+ + LT++ +Y V YHN H V + + +L +
Sbjct: 59 CIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 118
Query: 596 VKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNIT 654
+ + ALF A + HD+DH G +N+++ T S LA MY S LE+HH +
Sbjct: 119 ALDAV-FTDLEILAALFAAAI-HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG 176
Query: 655 VTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSW- 713
+LQ+D +IF ++S + + + +LATD++ L ++ + + + S
Sbjct: 177 FKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGV 236
Query: 714 ---DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPM 770
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM
Sbjct: 237 LLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPM 296
Query: 771 MDRN 774
D++
Sbjct: 297 CDKH 300
>U40372-1|AAA96961.1| 564|Homo sapiens PDE1C3 protein.
Length = 564
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 52 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 108
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 109 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 168
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 169 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 221
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 222 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 280
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 281 SQVGFIDFIVEPTFTVL 297
>U40371-1|AAC50437.1| 634|Homo sapiens 3',5' cyclic nucleotide
phosphodiesterase protein.
Length = 634
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 253
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 254 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 313
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 314 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 366
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 367 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 425
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 426 SQVGFIDFIVEPTFTVL 442
>BC022525-1|AAH22525.1| 634|Homo sapiens PDE1C protein protein.
Length = 634
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 253
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 254 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 313
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 314 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 366
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 367 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 425
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 426 SQVGFIDFIVEPTFTVL 442
>BC022479-1|AAH22479.1| 634|Homo sapiens PDE1C protein protein.
Length = 634
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 253
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 254 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 313
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 314 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 366
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 367 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 425
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 426 SQVGFIDFIVEPTFTVL 442
>AK091734-1|BAC03734.1| 769|Homo sapiens (EC 3.1.4.17). protein.
Length = 769
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 257 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 313
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 314 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 373
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 374 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 426
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 427 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 485
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 486 SQVGFIDFIVEPTFTVL 502
>AC006377-1|AAS07516.1| 591|Homo sapiens unknown protein.
Length = 591
Score = 106 bits (254), Expect = 4e-22
Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 547 DLFDMTQFDITTLTRFTLTVKKNY--RTVPYHNFDHGWTVAHAM-YAILKSDVKERFDYN 603
DL + I+ L F ++ Y PYHN H V + Y + K+ V ++
Sbjct: 154 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVA---NWL 210
Query: 604 KASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDG 662
A+ + HD +H G TN + +T S A +Y S LE+HH + +LQ D
Sbjct: 211 TELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDE 270
Query: 663 H-NIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDL 721
NI ++S +D++E + ++ATD++ F + ++ + EA +
Sbjct: 271 EMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------IEKPK 323
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPA 781
A+++ + AD+S AK W++ + + EEF+ QGD+E G P+ DR K
Sbjct: 324 ALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQ 382
Query: 782 SQVGFLSQICIPCYDML 798
SQVGF+ I P + +L
Sbjct: 383 SQVGFIDFIVEPTFTVL 399
>AC005759-2|AAC83047.1| 710|Homo sapiens CN4C_HUMAN protein.
Length = 710
Score = 104 bits (250), Expect = 1e-21
Identities = 77/264 (29%), Positives = 127/264 (48%), Gaps = 13/264 (4%)
Query: 541 IISMF--RDLFDMTQFDITTLTRFTLTVKKNYRT-VPYHNFDHGWTVAHAMYAILKSDVK 597
I S+F RDL Q TL + L ++ +Y V YHN H VA + + +L +
Sbjct: 350 IFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPAL 409
Query: 598 ERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVT 656
E + ALF + + HD+DH G +N+++ T LA MY S LE+HH +
Sbjct: 410 EAV-FTDLEILAALFASAI-HDVDHPGVSNQFLINTK--LALMYNDASVLENHHLAVGFK 465
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 466 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 525
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 526 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 585
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 586 KHTASVE-KSQVGFIDYIAHPLWE 608
>U86078-1|AAC51872.1| 536|Homo sapiens calmodulin-stimulated
phosphodiesterase PDE1B1 protein.
Length = 536
Score = 104 bits (249), Expect = 2e-21
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 14/248 (5%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 221 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F + ++ + E D P A+++ + AAD+S K W + + K + E
Sbjct: 338 CHFQQVKTMKTALQQLERI---DKPK----ALSLLLHAADISHPTKQWLVHSRWTKALME 390
Query: 752 EFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL-PNTKPMYA 810
EF+ QGDKE G P+ DR SQ+GF+ I P + +L + + +P+
Sbjct: 391 EFFRQGDKEAELGLPFSPLCDRTS-TLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLAD 449
Query: 811 MATKNLNR 818
+K+ N+
Sbjct: 450 EDSKSKNQ 457
>U56976-1|AAC50769.1| 536|Homo sapiens calmodulin dependent
phosphodiesterase PDE1B1 protein.
Length = 536
Score = 104 bits (249), Expect = 2e-21
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 14/248 (5%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 221 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F + ++ + E D P A+++ + AAD+S K W + + K + E
Sbjct: 338 CHFQQVKTMKTALQQLERI---DKPK----ALSLLLHAADISHPTKQWLVHSRWTKALME 390
Query: 752 EFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL-PNTKPMYA 810
EF+ QGDKE G P+ DR SQ+GF+ I P + +L + + +P+
Sbjct: 391 EFFRQGDKEAELGLPFSPLCDRTS-TLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLAD 449
Query: 811 MATKNLNR 818
+K+ N+
Sbjct: 450 EDSKSKNQ 457
>BX538092-1|CAD98011.1| 399|Homo sapiens hypothetical protein
protein.
Length = 399
Score = 104 bits (249), Expect = 2e-21
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 14/248 (5%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 84 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 140
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 141 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 200
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F + ++ + E D P A+++ + AAD+S K W + + K + E
Sbjct: 201 CHFQQVKTMKTALQQLERI---DKPK----ALSLLLHAADISHPTKQWLVHSRWTKALME 253
Query: 752 EFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL-PNTKPMYA 810
EF+ QGDKE G P+ DR SQ+GF+ I P + +L + + +P+
Sbjct: 254 EFFRQGDKEAELGLPFSPLCDRTS-TLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLAD 312
Query: 811 MATKNLNR 818
+K+ N+
Sbjct: 313 EDSKSKNQ 320
>BC032226-1|AAH32226.1| 536|Homo sapiens phosphodiesterase 1B,
calmodulin-dependent protein.
Length = 536
Score = 104 bits (249), Expect = 2e-21
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 14/248 (5%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 221 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F + ++ + E D P A+++ + AAD+S K W + + K + E
Sbjct: 338 CHFQQVKTMKTALQQLERI---DKPK----ALSLLLHAADISHPTKQWLVHSRWTKALME 390
Query: 752 EFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL-PNTKPMYA 810
EF+ QGDKE G P+ DR SQ+GF+ I P + +L + + +P+
Sbjct: 391 EFFRQGDKEAELGLPFSPLCDRTS-TLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLAD 449
Query: 811 MATKNLNR 818
+K+ N+
Sbjct: 450 EDSKSKNQ 457
>AJ401609-1|CAC82207.1| 516|Homo sapiens 3'5' cyclic nucleotide
phosphodiesterase 1B2 protein.
Length = 516
Score = 104 bits (249), Expect = 2e-21
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 14/248 (5%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 201 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 257
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 258 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 317
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFE 751
F + ++ + E D P A+++ + AAD+S K W + + K + E
Sbjct: 318 CHFQQVKTMKTALQQLERI---DKPK----ALSLLLHAADISHPTKQWLVHSRWTKALME 370
Query: 752 EFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRIL-PNTKPMYA 810
EF+ QGDKE G P+ DR SQ+GF+ I P + +L + + +P+
Sbjct: 371 EFFRQGDKEAELGLPFSPLCDRTS-TLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLAD 429
Query: 811 MATKNLNR 818
+K+ N+
Sbjct: 430 EDSKSKNQ 437
>EF108327-1|ABL14249.1| 502|Homo sapiens phosphodiesterase PDE7B2
protein.
Length = 502
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 170 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 229
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 230 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 287
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 288 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 345
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 346 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 403
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 404 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 438
>BC075083-1|AAH75083.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>BC075082-1|AAH75082.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>AL360178-1|CAH73075.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>AL138828-4|CAI95287.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>AL133319-1|CAH73332.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>AJ251860-1|CAB92441.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>AB209990-1|BAE06072.1| 586|Homo sapiens PDE7B variant protein
protein.
Length = 586
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 254 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 313
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 314 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 371
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 372 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 429
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 430 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 487
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 488 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 522
>AB038040-1|BAA96537.1| 450|Homo sapiens cyclic nucleotide
phosphodiesterase 7B protein.
Length = 450
Score = 103 bits (246), Expect = 4e-21
Identities = 75/276 (27%), Positives = 132/276 (47%), Gaps = 15/276 (5%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 118 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 178 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 235
Query: 641 YTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDK 699
Y S LE+HH+ T+ +L++ + +H+ E ++I + ILATD+ L +
Sbjct: 236 YQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTR 293
Query: 700 IRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDK 759
++ + + + +D R + I++ AD+ + WE+ + + + EEFY QG+
Sbjct: 294 LKAHLHNKDLRL--EDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 760 ERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCY 795
E+ P+ ++ K + P+ Q+GF+S I P +
Sbjct: 352 EQKFELEISPLCNQQK-DSIPSIQIGFMSYIVEPLF 386
>BC075822-1|AAH75822.1| 829|Homo sapiens phosphodiesterase 8A
protein.
Length = 829
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 536 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 592
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 593 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 652
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 653 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 712
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 713 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 772
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 773 -SIPKSQISFIDYFITDMFD 791
>BC060762-1|AAH60762.1| 829|Homo sapiens phosphodiesterase 8A
protein.
Length = 829
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 536 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 592
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 593 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 652
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 653 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 712
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 713 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 772
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 773 -SIPKSQISFIDYFITDMFD 791
>BC048317-1|AAH48317.1| 305|Homo sapiens PDE8A protein protein.
Length = 305
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 12 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 68
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 69 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 128
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 129 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 188
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 189 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 248
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 249 -SIPKSQISFIDYFITDMFD 267
>AF388187-1|AAL18614.1| 582|Homo sapiens cAMP phosphodiesterase
PDE8A5 protein.
Length = 582
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 289 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 345
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 346 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 405
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 406 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 465
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 466 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 525
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 526 -SIPKSQISFIDYFITDMFD 544
>AF388186-1|AAL18613.1| 582|Homo sapiens cAMP phosphodiesterase
PDE8A4 protein.
Length = 582
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 289 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 345
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 346 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 405
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 406 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 465
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 466 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 525
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 526 -SIPKSQISFIDYFITDMFD 544
>AF388185-1|AAL18612.1| 449|Homo sapiens cAMP phosphodiesterase
PDE8A3 protein.
Length = 449
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 156 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 212
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 213 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 272
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 273 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 332
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 333 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 392
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 393 -SIPKSQISFIDYFITDMFD 411
>AF388184-1|AAL18611.1| 783|Homo sapiens cAMP phosphodiesterase
PDE8A2 protein.
Length = 783
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 490 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 546
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 547 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 606
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 607 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 666
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 667 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 726
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 727 -SIPKSQISFIDYFITDMFD 745
>AF388183-1|AAL18610.1| 829|Homo sapiens cAMP phosphodiesterase
PDE8A1 protein.
Length = 829
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 536 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 592
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 593 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 652
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 653 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 712
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 713 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 772
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 773 -SIPKSQISFIDYFITDMFD 791
>AF332653-1|AAK57641.1| 829|Homo sapiens cAMP-specific cyclic
nucleotide phosphodiesterase PDE8A1 protein.
Length = 829
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 536 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 592
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 593 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 652
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 653 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 712
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 713 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 772
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 773 -SIPKSQISFIDYFITDMFD 791
>AF056490-1|AAC39763.1| 713|Homo sapiens cAMP-specific
phosphodiesterase 8A protein.
Length = 713
Score = 98.3 bits (234), Expect = 1e-19
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAM-YAILKSDVKERFDYNKASSRLALFVA 614
+TL + ++ NY + PYHN H V HA Y + K +KE D +A +A
Sbjct: 420 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLD---PIDEVAALIA 476
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + D NIF ++
Sbjct: 477 ATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERN 536
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-----------IRELYRSDEAQ----FSWDDPS 717
DY+ + I +LAT++ F +++K + E +D+ Q P
Sbjct: 537 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 596
Query: 718 HRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKP 776
+R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 597 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTC 656
Query: 777 EEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 657 -SIPKSQISFIDYFITDMFD 675
>U36798-1|AAB18673.1| 1141|Homo sapiens platelet cGI-PDE protein.
Length = 1141
Score = 95.9 bits (228), Expect = 6e-19
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 0.88
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>M91667-1|AAA35912.2| 1141|Homo sapiens cGMP-inhibited cAMP
phosphodiesterase protein.
Length = 1141
Score = 95.9 bits (228), Expect = 6e-19
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 0.88
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>BC117371-1|AAI17372.1| 1141|Homo sapiens phosphodiesterase 3A,
cGMP-inhibited protein.
Length = 1141
Score = 95.9 bits (228), Expect = 6e-19
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 0.88
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>BC117369-1|AAI17370.1| 1141|Homo sapiens phosphodiesterase 3A,
cGMP-inhibited protein.
Length = 1141
Score = 95.9 bits (228), Expect = 6e-19
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 0.88
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>AJ005036-1|CAA06304.1| 1141|Homo sapiens phosphodiesterase 3A
protein.
Length = 1141
Score = 95.9 bits (228), Expect = 6e-19
Identities = 70/238 (29%), Positives = 112/238 (47%), Gaps = 12/238 (5%)
Query: 565 TVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKASSRL------ALFVACLCH 618
TV ++ + + D G+T H Y K+ Y S + AL+VA H
Sbjct: 777 TVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMH 836
Query: 619 DLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIFSHISSEDYKE 676
D DH G TN ++ T++P A +Y S LE+HH + + + +N ++ ++K
Sbjct: 837 DYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKH 896
Query: 677 ILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASA 736
+ ILATDL F + K +D+ W + + R L + + AD++ A
Sbjct: 897 FRFLVIEAILATDLKKHFDFVAKFNGKV-NDDVGIDWTNENDRLLVCQMCIKLADINGPA 955
Query: 737 KPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQVGFLSQICIP 793
K E+ ++ I EFY+QGD+E + G +PI P MDR+ P + Q F+S I P
Sbjct: 956 KCKELHLQWTDGIVNEFYEQGDEEASLG-LPISPFMDRSAP-QLANLQESFISHIVGP 1011
Score = 35.5 bits (78), Expect = 0.88
Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 483 IMRKEQKYRVALEVLSYHNTCREYEVQAML-LDK-----EPLNVDFADFYLDPFR----- 531
I++ E + E L + C Y + M+ LDK EPL +D D ++
Sbjct: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
Query: 532 -FDEFE----KCKCIIS-----MFRD--LFDMTQFDITTLTRFTLTVKKNYRTVPYHNFD 579
FD E KC I+S +F D LF+ + I + ++ YR +PYHN
Sbjct: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
Query: 580 HGWTVAHAMY 589
H V HA++
Sbjct: 756 HATDVLHAVW 765
>AY423729-1|AAS00492.1| 350|Homo sapiens proliferation-inducing
gene 22 protein protein.
Length = 350
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 60 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 116
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 117 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 176
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 177 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 236
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 237 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 295
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 296 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 338
>AY129950-3|AAN71727.1| 788|Homo sapiens cAMP-specific
phosphodiesterase 8B3 protein.
Length = 788
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 498 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 554
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 555 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 614
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 615 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 674
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 675 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 733
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 734 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 776
>AY129950-2|AAN71726.1| 838|Homo sapiens cAMP-specific
phosphodiesterase 8B2 protein.
Length = 838
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 548 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 604
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 605 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 664
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 665 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 724
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 725 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 783
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 784 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 826
>AY129950-1|AAN71725.1| 885|Homo sapiens cAMP-specific
phosphodiesterase 8B1 protein.
Length = 885
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 595 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 651
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 652 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 711
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 712 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 771
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 772 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 830
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 831 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 873
>AY129949-1|AAN71724.1| 788|Homo sapiens cAMP-specific
phosphodiesterase 8B3 protein.
Length = 788
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 498 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 554
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 555 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 614
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 615 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 674
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 675 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 733
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 734 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 776
>AY129948-1|AAN71723.1| 838|Homo sapiens cAMP-specific
phosphodiesterase 8B2 protein.
Length = 838
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 548 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 604
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 605 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 664
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 665 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 724
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 725 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 783
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 784 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 826
>AL831924-1|CAD38584.1| 843|Homo sapiens hypothetical protein
protein.
Length = 843
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 553 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 609
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 610 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 669
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 670 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 729
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 730 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 788
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 789 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 831
>AF079529-1|AAC69564.2| 885|Homo sapiens cAMP-specific
phosphodiesterase 8B1 protein.
Length = 885
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 595 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 651
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 652 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 711
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 712 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 771
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 772 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 830
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 831 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 873
>AB085827-1|BAC53765.1| 865|Homo sapiens phosphodiesterase 8B4
protein.
Length = 865
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 575 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 631
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 632 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 691
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 692 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 751
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 752 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 810
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 811 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 853
>AB085826-1|BAC53764.1| 830|Homo sapiens phosphodiesterase 8B3
protein.
Length = 830
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 540 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 596
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 597 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 656
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 657 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 716
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 717 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 775
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 776 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 818
>AB085825-1|BAC53763.1| 788|Homo sapiens phosphodiestearse 8B2
protein.
Length = 788
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 498 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 554
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 555 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 614
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 615 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 674
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 675 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 733
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 734 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 776
>AB085824-1|BAC53762.1| 885|Homo sapiens phosphodiesterase 8B1
protein.
Length = 885
Score = 95.5 bits (227), Expect = 8e-19
Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 595 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 651
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 652 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 711
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----------PSHRDL 721
Y+ + I +LAT++ F +++K + + + A+ D P ++ L
Sbjct: 712 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQIL 771
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 772 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 830
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 831 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 873
>X95520-1|CAA64774.1| 1112|Homo sapiens cyclic nucleotide
phosphodiesterase protein.
Length = 1112
Score = 94.3 bits (224), Expect = 2e-18
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 812 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFL 871
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
H+ ++K + ILATDL F L + + W + + R L +
Sbjct: 872 LHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQV 931
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ AK ++ +K + I EFY+QGD+E G +PI P MDR+ P + Q
Sbjct: 932 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLG-LPISPFMDRSSP-QLAKLQE 989
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 990 SFITHIVGP 998
>U38178-1|AAC50724.1| 1112|Homo sapiens cyclic nucleotide
phophodiesterase protein.
Length = 1112
Score = 94.3 bits (224), Expect = 2e-18
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 812 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFL 871
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
H+ ++K + ILATDL F L + + W + + R L +
Sbjct: 872 LHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQV 931
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ AK ++ +K + I EFY+QGD+E G +PI P MDR+ P + Q
Sbjct: 932 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLG-LPISPFMDRSSP-QLAKLQE 989
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 990 SFITHIVGP 998
>D50640-1|BAA09306.1| 1112|Homo sapiens phosphodiesterase 3B
protein.
Length = 1112
Score = 94.3 bits (224), Expect = 2e-18
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 812 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFL 871
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
H+ ++K + ILATDL F L + + W + + R L +
Sbjct: 872 LHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQV 931
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ AK ++ +K + I EFY+QGD+E G +PI P MDR+ P + Q
Sbjct: 932 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLG-LPISPFMDRSSP-QLAKLQE 989
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 990 SFITHIVGP 998
>AY459346-1|AAR24292.1| 1112|Homo sapiens cGMP-inhibited cAMP
phophodiesterase protein.
Length = 1112
Score = 94.3 bits (224), Expect = 2e-18
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 6/189 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTI-LQQDGHNIF 666
+AL+VA HD DH G TN ++ T +P A +Y S LE+HH + L + +N
Sbjct: 812 MALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFL 871
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ-FSWDDPSHRDLAMAI 725
H+ ++K + ILATDL F L + + W + + R L +
Sbjct: 872 LHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQV 931
Query: 726 SMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPI-PMMDRNKPEEQPASQV 784
+ AD++ AK ++ +K + I EFY+QGD+E G +PI P MDR+ P + Q
Sbjct: 932 CIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLG-LPISPFMDRSSP-QLAKLQE 989
Query: 785 GFLSQICIP 793
F++ I P
Sbjct: 990 SFITHIVGP 998
>BC035144-1|AAH35144.1| 385|Homo sapiens PDE8B protein protein.
Length = 385
Score = 93.1 bits (221), Expect = 4e-18
Identities = 75/284 (26%), Positives = 126/284 (44%), Gaps = 21/284 (7%)
Query: 557 TTLTRFTLTVKKNYRTV-PYHNFDHGWTVAHAMYAIL-KSDVKERFDYNKASSRLALFVA 614
TTL + ++ NY + YHN H V HA L K VK D +A +A
Sbjct: 95 TTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQ---LDEVAALIA 151
Query: 615 CLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIFSHISSE 672
HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF +I
Sbjct: 152 ATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRN 211
Query: 673 DYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD----PSHRD------L 721
Y+ + I +LAT++ F +++K + + + A+ D P+ ++ L
Sbjct: 212 HYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFLENQIL 271
Query: 722 AMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRNKPEEQP 780
+ + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN P
Sbjct: 272 IKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC-SIP 330
Query: 781 ASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
SQ+ F+ +D + + + N WK D
Sbjct: 331 KSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 373
>U66349-1|AAB96878.1| 427|Homo sapiens PDE4C-delta109 protein.
Length = 427
Score = 91.9 bits (218), Expect = 1e-17
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 6/193 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFS 667
LA A HD+DH G +N+++ T S LA MY S LE+HH + +LQ + +IF
Sbjct: 134 LAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQ 193
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FSWDDPSHRDLAM 723
++S++ + + +LATD++ L ++ + + + D+ S R +
Sbjct: 194 NLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVL 253
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQ 783
+ ADLS KP + + I EF+ QGD+ER +G PM D++ + SQ
Sbjct: 254 QNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVE-KSQ 312
Query: 784 VGFLSQICIPCYD 796
VGF+ I P ++
Sbjct: 313 VGFIDYIAHPLWE 325
>AC005759-4|AAC83048.1| 427|Homo sapiens PDE4C-delta109 protein.
Length = 427
Score = 91.9 bits (218), Expect = 1e-17
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 6/193 (3%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGHNIFS 667
LA A HD+DH G +N+++ T S LA MY S LE+HH + +LQ + +IF
Sbjct: 134 LAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQ 193
Query: 668 HISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FSWDDPSHRDLAM 723
++S++ + + +LATD++ L ++ + + + D+ S R +
Sbjct: 194 NLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVL 253
Query: 724 AISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQ 783
+ ADLS KP + + I EF+ QGD+ER +G PM D++ + SQ
Sbjct: 254 QNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVE-KSQ 312
Query: 784 VGFLSQICIPCYD 796
VGF+ I P ++
Sbjct: 313 VGFIDYIAHPLWE 325
>BC047627-1|AAH47627.1| 241|Homo sapiens PDE8B protein protein.
Length = 241
Score = 81.8 bits (193), Expect = 1e-14
Identities = 58/230 (25%), Positives = 104/230 (45%), Gaps = 16/230 (6%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYT-TSTLEHHHFNITVTILQQDGH-NIF 666
+A +A HD+DH G TN ++ S LA +Y T+ LE HH + + +D NIF
Sbjct: 2 VAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIF 61
Query: 667 SHISSEDYKEILGFIRHCILATDLAAFFPNLDK-IRELYRSDEAQFSWDD---------- 715
+I Y+ + I +LAT++ F +++K + + + A+ D
Sbjct: 62 KNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNF 121
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRN 774
P ++ L + + AD++ +P ++ I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 122 PENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRN 181
Query: 775 KPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARAD 824
P SQ+ F+ +D + + + N WK D
Sbjct: 182 TC-SIPKSQISFIDYFITDMFD-AWDAFAHLPALMQHLADNYKHWKTLDD 229
>AC073834-2|AAX93113.1| 125|Homo sapiens unknown protein.
Length = 125
Score = 80.6 bits (190), Expect = 2e-14
Identities = 37/102 (36%), Positives = 58/102 (56%), Gaps = 1/102 (0%)
Query: 727 MTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRI-PIPMMDRNKPEEQPASQVG 785
MTA DL A KPWEI + +++ EF++QGD+ER ++ P + DRN+ +E P Q+
Sbjct: 4 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 63
Query: 786 FLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKIL 827
++ IC+P Y L ++ KPM N ++W+ K L
Sbjct: 64 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRL 105
>U40584-1|AAB50018.1| 184|Homo sapiens
calcium/calmodulin-stimulated cyclic nucleotide
phosphodiesterase protein.
Length = 184
Score = 71.7 bits (168), Expect = 1e-11
Identities = 46/168 (27%), Positives = 82/168 (48%), Gaps = 12/168 (7%)
Query: 574 PYHNFDHGWTVAHAMYA-ILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSE 632
PYHN H V ++ +L++ + + LA+ A HD +H G TN + +
Sbjct: 21 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEL---LAIIFAAAIHDYEHTGTTNSFHIQ 77
Query: 633 TASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLA 691
T S A +Y S LE+HH + ++Q D NIF +++ +++ E+ + +LATD++
Sbjct: 78 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 137
Query: 692 AFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPW 739
F + ++ + Q D S A+++ + AAD+S K W
Sbjct: 138 CHFQQVKTMKTALQ----QLERIDKSK---ALSLLLHAADISHPTKQW 178
>M94539-1|AAA58405.1| 116|Homo sapiens cyclic nucleotide
phosphodiesterase protein.
Length = 116
Score = 63.3 bits (147), Expect = 4e-09
Identities = 29/84 (34%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 609 LALFVACLCHDLDHRGYTNKYMSETASPLAAMYTT-STLEHHHFNITVTILQQDGHNIFS 667
LA+ A HD +H G TN + +T S A +Y S LE+HH + ++Q D NIF
Sbjct: 33 LAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFI 92
Query: 668 HISSEDYKEILGFIRHCILATDLA 691
+++ +++ E+ + +LATD+A
Sbjct: 93 NLTKDEFVELRALVIEMVLATDMA 116
>L20968-1|AAA03591.1| 251|Homo sapiens phosphodiesterase protein.
Length = 251
Score = 55.2 bits (127), Expect = 1e-06
Identities = 38/144 (26%), Positives = 69/144 (47%), Gaps = 5/144 (3%)
Query: 657 ILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQ----FS 712
+LQ + +IF ++S++ + + +LATD++ L ++ + + +
Sbjct: 7 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 66
Query: 713 WDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMD 772
D+ S R + + ADLS KP + + I EF+ QGD+ER +G PM D
Sbjct: 67 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 126
Query: 773 RNKPEEQPASQVGFLSQICIPCYD 796
++ + SQVGF+ I P ++
Sbjct: 127 KHTASVE-KSQVGFIDYIAHPLWE 149
>AL138828-3|CAI95286.1| 199|Homo sapiens phosphodiesterase 7B
protein.
Length = 199
Score = 50.4 bits (115), Expect = 3e-05
Identities = 36/121 (29%), Positives = 54/121 (44%), Gaps = 9/121 (7%)
Query: 528 DPFRFDEFEKCKCIISMFRDLFDMT------QFDITTLTRFTLTVKKNYRTV-PYHNFDH 580
D F FD ++++ LF+ + D+ TL RF + V+++Y + PYHN H
Sbjct: 12 DIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 71
Query: 581 GWTVAHAMYAILKSDVKERFDYNKASSRLALFVACLCHDLDHRGYTNKYMSETASPLAAM 640
V AM+ LK F L L A HD+DH G ++ +T LA +
Sbjct: 72 AADVTQAMHCYLKEPKLASF-LTPLDIMLGLLAAA-AHDVDHPGVNQPFLIKTNHHLANL 129
Query: 641 Y 641
Y
Sbjct: 130 Y 130
>AY266362-1|AAP31234.1| 102|Homo sapiens phosphodiesterase isozyme
4 protein.
Length = 102
Score = 48.0 bits (109), Expect = 2e-04
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 714 DDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDR 773
D+ S R + + ADLS KP E+ + I EF+ QGD+ER G PM D+
Sbjct: 16 DNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDK 75
Query: 774 NKPEEQPASQVGFLSQICIPCYD 796
+ + SQVGF+ I P ++
Sbjct: 76 HTASVE-KSQVGFIDYIVHPLWE 97
>AC073892-1|AAY24130.1| 98|Homo sapiens unknown protein.
Length = 98
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 2/78 (2%)
Query: 295 VALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFL 354
+A+ +L+ ++E S LL+VV +FEE L++++K+I+ AQ L+ +R S+ L
Sbjct: 11 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 70
Query: 355 VDYRNSELVSTVFDLKFE 372
++ S +V F FE
Sbjct: 71 LEDIESPVVK--FTKSFE 86
>AL109778-1|CAB52432.1| 178|Homo sapiens PDE8A; phosphodiesterase
8A protein.
Length = 178
Score = 41.5 bits (93), Expect = 0.013
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRN 774
P +R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 60 PENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRN 119
Query: 775 KPEEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 120 TC-SIPKSQISFIDYFITDMFD 140
>AL109687-1|CAB52020.1| 160|Homo sapiens PDE8A; phosphodiesterase
8A protein.
Length = 160
Score = 41.5 bits (93), Expect = 0.013
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 716 PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAG-RIPIPMMDRN 774
P +R L + + AD+S +P + I+ I EE++ Q D+E+ G + +P+ DRN
Sbjct: 42 PENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRN 101
Query: 775 KPEEQPASQVGFLSQICIPCYD 796
P SQ+ F+ +D
Sbjct: 102 TC-SIPKSQISFIDYFITDMFD 122
>X62693-1|CAA44570.1| 51|Homo sapiens cGMP phosphodiesterase beta
subunit protein.
Length = 51
Score = 37.5 bits (83), Expect = 0.22
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 414 FNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDE 460
F+ DE T YKT ++L PI V+ V+ VNK + +F +DE
Sbjct: 4 FSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDE 50
>AB041798-1|BAB92963.1| 55|Homo sapiens phosphodiesterase 10A1
(PDE10A1) protein.
Length = 55
Score = 36.3 bits (80), Expect = 0.50
Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 85 KKKHSDAEEQETISHYLNRNKDYLETYILESVPQDVVEKWLHMKMKNN 132
K +H E + YL+ + L+ ++ ESV + VEKWL K KNN
Sbjct: 7 KSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWL--KRKNN 52
>AL137265-1|CAB70664.1| 992|Homo sapiens hypothetical protein
protein.
Length = 992
Score = 33.5 bits (73), Expect = 3.5
Identities = 21/51 (41%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Query: 9 LAYGDKDSSRSSNTPIQSKTSDGRSPQLLPPIGKAEIGFSGTPASLKSPTE 59
L DKD S+SS +QSK S G +L PP+ E S P SL + E
Sbjct: 218 LGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQS-PPRSLATEEE 267
>Z85987-1|CAI42222.1| 961|Homo sapiens FYVE, RhoGEF and PH domain
containing 1 (faciogenital dysplasia) protein.
Length = 961
Score = 32.3 bits (70), Expect = 8.2
Identities = 28/92 (30%), Positives = 39/92 (42%), Gaps = 3/92 (3%)
Query: 697 LDKIRELYRSDEAQFSWDD--PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFY 754
+D I S+E F DD PSH L A+ A A P + V EE
Sbjct: 285 IDSISSPSNSEETCFVSDDGPPSH-SLCPGPPALASVPVALADPHRPGSQEVDSDLEEED 343
Query: 755 DQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
D+ ++E IP+P+M+R + E Q F
Sbjct: 344 DEEEEEEKDREIPVPLMERQESVELTVQQKVF 375
>U11690-1|AAA57004.1| 961|Homo sapiens FGD1 protein.
Length = 961
Score = 32.3 bits (70), Expect = 8.2
Identities = 28/92 (30%), Positives = 39/92 (42%), Gaps = 3/92 (3%)
Query: 697 LDKIRELYRSDEAQFSWDD--PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFY 754
+D I S+E F DD PSH L A+ A A P + V EE
Sbjct: 285 IDSISSPSNSEETCFVSDDGPPSH-SLCPGPPALASVPVALADPHRPGSQEVDSDLEEED 343
Query: 755 DQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
D+ ++E IP+P+M+R + E Q F
Sbjct: 344 DEEEEEEKDREIPVPLMERQESVELTVQQKVF 375
>BC034530-1|AAH34530.1| 961|Homo sapiens FYVE, RhoGEF and PH domain
containing 1 (faciogenital dysplasia) protein.
Length = 961
Score = 32.3 bits (70), Expect = 8.2
Identities = 28/92 (30%), Positives = 39/92 (42%), Gaps = 3/92 (3%)
Query: 697 LDKIRELYRSDEAQFSWDD--PSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFY 754
+D I S+E F DD PSH L A+ A A P + V EE
Sbjct: 285 IDSISSPSNSEETCFVSDDGPPSH-SLCPGPPALASVPVALADPHRPGSQEVDSDLEEED 343
Query: 755 DQGDKERAAGRIPIPMMDRNKPEEQPASQVGF 786
D+ ++E IP+P+M+R + E Q F
Sbjct: 344 DEEEEEEKDREIPVPLMERQESVELTVQQKVF 375
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 129,489,764
Number of Sequences: 224733
Number of extensions: 5355764
Number of successful extensions: 13802
Number of sequences better than 10.0: 226
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 12811
Number of HSP's gapped (non-prelim): 339
length of query: 929
length of database: 73,234,838
effective HSP length: 97
effective length of query: 832
effective length of database: 51,435,737
effective search space: 42794533184
effective search space used: 42794533184
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 70 (32.3 bits)
- SilkBase 1999-2023 -