Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002032-TA|BGIBMGA002032-PA|IPR008271|Serine/threonine
protein kinase, active site, IPR000719|Protein kinase,
IPR002290|Serine/threonine protein kinase, IPR001245|Tyrosine protein
kinase, IPR011009|Protein kinase-like
(470 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U07358-1|AAA67343.1| 859|Homo sapiens serine/threonine protein ... 415 e-115
BC050050-1|AAH50050.1| 567|Homo sapiens MAP3K12 protein protein. 415 e-115
AF283475-1|AAL67158.1| 859|Homo sapiens zipper protein kinase p... 415 e-115
AB001872-1|BAA24817.1| 966|Homo sapiens leucine zipper bearing ... 414 e-115
BC064543-1|AAH64543.1| 847|Homo sapiens mitogen-activated prote... 226 1e-58
U07747-1|AAA19647.1| 847|Homo sapiens serine/threonine protein ... 225 2e-58
L32976-1|AAA59859.1| 847|Homo sapiens protein kinase protein. 225 2e-58
BC011263-1|AAH11263.1| 847|Homo sapiens mitogen-activated prote... 225 2e-58
AK222781-1|BAD96501.1| 847|Homo sapiens mitogen-activated prote... 225 2e-58
Z48615-1|CAA88531.1| 953|Homo sapiens serine/threonine kinase w... 223 1e-57
X90846-1|CAA62351.1| 954|Homo sapiens mixed lineage kinase 2 pr... 223 1e-57
BC111726-1|AAI11727.1| 656|Homo sapiens MAP3K13 protein protein. 223 1e-57
AY327900-1|AAQ23054.1| 1104|Homo sapiens mixed-lineage protein k... 216 2e-55
BC133706-1|AAI33707.1| 1104|Homo sapiens MAP3K9 protein protein. 215 2e-55
BC111407-1|AAI11408.1| 1103|Homo sapiens MAP3K9 protein protein. 215 2e-55
AF251442-1|AAG44591.1| 1066|Homo sapiens mixed lineage kinase ML... 215 2e-55
BC001401-1|AAH01401.1| 455|Homo sapiens sterile alpha motif and... 215 4e-55
AF480462-1|AAL85892.1| 455|Homo sapiens mixed lineage kinase-re... 215 4e-55
AF325454-1|AAK11615.1| 455|Homo sapiens mixed lineage kinase pr... 215 4e-55
AB049734-1|BAB16445.1| 455|Homo sapiens MLTK-beta protein. 215 4e-55
AF480461-1|AAL85891.1| 800|Homo sapiens mixed lineage kinase-re... 213 1e-54
AF251441-1|AAF65822.1| 800|Homo sapiens sterile-alpha motif and... 213 1e-54
AF238255-1|AAF63490.1| 800|Homo sapiens mixed lineage kinase ZA... 213 1e-54
AB208974-1|BAD92211.1| 845|Homo sapiens Plaucible mixed-lineage... 213 1e-54
AB049733-1|BAB16444.1| 800|Homo sapiens MLTK-alpha protein. 213 1e-54
AB030034-1|BAB12040.1| 800|Homo sapiens plaucible mixed-lineage... 213 1e-54
AL133380-4|CAI23046.1| 1036|Homo sapiens mixed lineage kinase 4 ... 208 3e-53
AL133380-3|CAI23045.1| 570|Homo sapiens mixed lineage kinase 4 ... 208 3e-53
AJ311798-1|CAC84640.1| 1036|Homo sapiens mixed lineage kinase 4b... 206 1e-52
AJ311797-1|CAC84639.1| 570|Homo sapiens mixed lineage kinase 4a... 206 1e-52
AF465843-1|AAO33376.1| 312|Homo sapiens cervical cancer suppres... 204 4e-52
AC013461-1|AAX93067.1| 400|Homo sapiens unknown protein. 201 4e-51
M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein. 159 1e-38
M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein. 159 1e-38
BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma vi... 159 1e-38
BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma vi... 159 1e-38
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 159 1e-38
AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3 pro... 159 1e-38
X03484-1|CAA27204.1| 648|Homo sapiens protein ( Human mRNA for ... 157 8e-38
L00212-1|AAA60247.1| 421|Homo sapiens RAF1 protein. 157 8e-38
BC018119-1|AAH18119.1| 648|Homo sapiens v-raf-1 murine leukemia... 157 8e-38
AY271661-1|AAP03432.1| 648|Homo sapiens v-raf-1 murine leukemia... 157 8e-38
M15990-1|AAA35735.1| 543|Homo sapiens protein ( Human c-yes-1 m... 154 6e-37
BC048960-1|AAH48960.1| 543|Homo sapiens v-yes-1 Yamaguchi sarco... 154 6e-37
M59371-1|AAA53375.1| 976|Homo sapiens protein-tyrosine kinase p... 154 7e-37
BC037166-1|AAH37166.1| 976|Homo sapiens EPH receptor A2 protein. 154 7e-37
AL451042-1|CAH71943.1| 976|Homo sapiens EPH receptor A2 protein. 154 7e-37
X02647-1|CAA26485.1| 351|Homo sapiens c-src protein. 153 1e-36
K03218-1|AAA60584.1| 536|Homo sapiens SRC protein. 153 1e-36
DQ314875-1|ABC40734.1| 606|Homo sapiens mitogen-activated prote... 153 1e-36
BT019654-1|AAV38460.1| 579|Homo sapiens mitogen-activated prote... 153 1e-36
BC051270-1|AAH51270.2| 536|Homo sapiens v-src sarcoma (Schmidt-... 153 1e-36
BC017715-1|AAH17715.1| 579|Homo sapiens mitogen-activated prote... 153 1e-36
BC011566-1|AAH11566.1| 536|Homo sapiens SRC protein protein. 153 1e-36
AL133293-2|CAC10573.1| 542|Homo sapiens v-src sarcoma (Schmidt-... 153 1e-36
AL133293-1|CAC34523.1| 536|Homo sapiens v-src sarcoma (Schmidt-... 153 1e-36
AL121964-4|CAI19612.1| 606|Homo sapiens mitogen-activated prote... 153 1e-36
AL121964-3|CAI19611.1| 579|Homo sapiens mitogen-activated prote... 153 1e-36
AL121964-2|CAI19609.1| 491|Homo sapiens mitogen-activated prote... 153 1e-36
AL121964-1|CAI19610.1| 518|Homo sapiens mitogen-activated prote... 153 1e-36
AL121837-4|CAI23533.1| 579|Homo sapiens mitogen-activated prote... 153 1e-36
AL121837-3|CAI23532.1| 606|Homo sapiens mitogen-activated prote... 153 1e-36
AL121837-2|CAI23531.1| 491|Homo sapiens mitogen-activated prote... 153 1e-36
AL121837-1|CAI23530.1| 518|Homo sapiens mitogen-activated prote... 153 1e-36
AF218074-1|AAF27652.1| 491|Homo sapiens TGF beta-activated kina... 153 1e-36
AB009358-1|BAA25027.2| 518|Homo sapiens TGF-beta activated kina... 153 1e-36
AB009357-1|BAA25026.1| 606|Homo sapiens TGF-beta activated kina... 153 1e-36
AB009356-1|BAA25025.1| 579|Homo sapiens TGF-beta activated kina... 153 1e-36
BT019655-1|AAV38461.1| 606|Homo sapiens mitogen-activated prote... 152 3e-36
X77278-1|CAA54493.1| 507|Homo sapiens HYL tyrosine kinase protein. 150 1e-35
S75164-1|AAC60645.1| 507|Homo sapiens megakaryocyte-associated ... 150 1e-35
BC003109-1|AAH03109.1| 507|Homo sapiens megakaryocyte-associate... 150 1e-35
BC000114-1|AAH00114.1| 507|Homo sapiens megakaryocyte-associate... 150 1e-35
AC005777-1|AAC62843.1| 507|Homo sapiens MATK_HUMAN protein. 150 1e-35
U07236-1|AAA18225.1| 512|Homo sapiens lymphocyte-specific prote... 148 4e-35
S65186-1|AAB28072.2| 620|Homo sapiens EMT protein. 148 4e-35
L10717-1|AAA36748.1| 620|Homo sapiens tyrosine kinase protein. 148 4e-35
D13720-1|BAA02873.1| 620|Homo sapiens ITK protein. 148 4e-35
BC109078-1|AAI09079.1| 620|Homo sapiens IL2-inducible T-cell ki... 148 4e-35
BC109077-1|AAI09078.1| 620|Homo sapiens IL2-inducible T-cell ki... 148 4e-35
Z97989-4|CAI22300.1| 537|Homo sapiens FYN oncogene related to S... 147 6e-35
M14333-1|AAC08285.1| 537|Homo sapiens protein ( Homo sapiens c-... 147 6e-35
Z84466-8|CAI42468.1| 606|Homo sapiens v-raf murine sarcoma 3611... 147 8e-35
X14055-1|CAA32211.1| 509|Homo sapiens protein ( Human lymphocyt... 147 8e-35
X13529-1|CAA31884.1| 509|Homo sapiens protein ( Human lck mRNA ... 147 8e-35
X04790-1|CAA28476.1| 606|Homo sapiens protein ( Human mRNA for ... 147 8e-35
U01337-1|AAB03517.1| 606|Homo sapiens Ser/Thr protein kinase pr... 147 8e-35
L36642-1|AAA74243.1| 998|Homo sapiens receptor protein-tyrosine... 147 8e-35
L24038-1|AAA65219.1| 606|Homo sapiens ARAF1 protein. 147 8e-35
BT019864-1|AAV38667.1| 606|Homo sapiens v-raf murine sarcoma 36... 147 8e-35
BC126151-1|AAI26152.1| 998|Homo sapiens EPH receptor A7 protein. 147 8e-35
BC126125-1|AAI26126.1| 998|Homo sapiens EPH receptor A7 protein. 147 8e-35
BC007514-1|AAH07514.1| 609|Homo sapiens ARAF protein protein. 147 8e-35
BC002466-1|AAH02466.1| 606|Homo sapiens v-raf murine sarcoma 36... 147 8e-35
AL591036-1|CAH73650.1| 998|Homo sapiens EPH receptor A7 protein. 147 8e-35
AL354857-1|CAH72780.1| 998|Homo sapiens EPH receptor A7 protein. 147 8e-35
AL121991-2|CAI22320.1| 496|Homo sapiens lymphocyte-specific pro... 147 8e-35
AL121966-2|CAI19722.1| 998|Homo sapiens EPH receptor A7 protein. 147 8e-35
AF228313-1|AAF34794.1| 496|Homo sapiens tyrosine kinase LCK pro... 147 8e-35
AB209269-1|BAD92506.1| 1000|Homo sapiens ephrin receptor EphA7 v... 147 8e-35
Z25428-1|CAA80915.1| 111|Homo sapiens protein-serine/threonine ... 146 1e-34
X83107-1|CAA58169.1| 675|Homo sapiens bmx protein. 146 1e-34
M14676-1|AAA36615.1| 537|Homo sapiens protein ( Human src-like ... 146 1e-34
BC016652-1|AAH16652.1| 675|Homo sapiens BMX non-receptor tyrosi... 146 1e-34
AF045459-1|AAC08966.1| 697|Homo sapiens Etk/Bmx cytosolic tyros... 146 1e-34
M83941-1|AAA58633.1| 983|Homo sapiens receptor protein kinase p... 145 3e-34
BC063282-1|AAH63282.1| 983|Homo sapiens EPH receptor A3 protein. 145 3e-34
AF213459-1|AAG43576.1| 983|Homo sapiens ephrin receptor EPHA3 c... 145 3e-34
M36881-1|AAA59502.1| 509|Homo sapiens lymphocyte-specific prote... 144 4e-34
AL035703-1|CAB81612.1| 1005|Homo sapiens EPH receptor A8 protein. 144 4e-34
AB040892-1|BAA95983.1| 853|Homo sapiens KIAA1459 protein protein. 144 4e-34
L40636-1|AAB08520.1| 984|Homo sapiens protein tyrosine kinase p... 144 8e-34
J03358-1|AAA61190.1| 822|Homo sapiens FER protein. 144 8e-34
X52192-1|CAA36438.1| 822|Homo sapiens c-fes protein. 143 1e-33
AY513657-1|AAS82869.1| 752|Homo sapiens proto-oncogene c-fes va... 143 1e-33
AY513656-1|AAS82868.1| 764|Homo sapiens proto-oncogene c-fes va... 143 1e-33
AY513654-1|AAS82866.1| 694|Homo sapiens proto-oncogene c-fes va... 143 1e-33
X06292-1|CAA29619.1| 822|Homo sapiens NCP92 protein. 142 2e-33
M13829-1|AAB08754.1| 298|Homo sapiens raf related protein protein. 142 2e-33
BC111744-1|AAI11745.1| 984|Homo sapiens EPH receptor B1 protein. 142 2e-33
BC035357-1|AAH35357.1| 822|Homo sapiens feline sarcoma oncogene... 142 2e-33
X05027-1|CAA28691.1| 507|Homo sapiens protein ( Human T cell-sp... 142 2e-33
AF037332-1|AAD02031.1| 973|Homo sapiens Eph-like receptor tyros... 142 3e-33
S71669-1|AAB30995.1| 465|Homo sapiens lsk protein. 141 4e-33
M79321-1|AAB50019.1| 491|Homo sapiens Lyn B protein protein. 141 4e-33
M16038-1|AAA59540.1| 512|Homo sapiens LYN protein. 141 4e-33
BC126458-1|AAI26459.1| 512|Homo sapiens LYN protein protein. 141 4e-33
BC126456-1|AAI26457.1| 512|Homo sapiens LYN protein protein. 141 4e-33
BC075002-1|AAH75002.1| 512|Homo sapiens v-yes-1 Yamaguchi sarco... 141 4e-33
BC075001-1|AAH75001.1| 512|Homo sapiens v-yes-1 Yamaguchi sarco... 141 4e-33
BC068551-1|AAH68551.1| 582|Homo sapiens LYN protein protein. 141 4e-33
BC059394-1|AAH59394.1| 582|Homo sapiens LYN protein protein. 141 4e-33
U22322-1|AAC50116.1| 505|Homo sapiens Rak protein. 141 5e-33
U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase ... 141 5e-33
L41939-1|AAA99310.1| 987|Homo sapiens protein-tyrosine kinase p... 141 5e-33
L36643-1|AAA74244.1| 970|Homo sapiens receptor protein-tyrosine... 141 5e-33
D29767-1|BAA06171.1| 631|Homo sapiens Tec protein-tyrosine kina... 141 5e-33
BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase prot... 141 5e-33
AL512444-4|CAI16429.1| 1055|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL512444-3|CAI16428.1| 987|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL512444-2|CAI16430.2| 986|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL512444-1|CAI16427.1| 946|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase prot... 141 5e-33
AL158086-8|CAI22898.1| 1055|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL158086-7|CAI22899.2| 986|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL158086-6|CAI22897.1| 987|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase prot... 141 5e-33
AL121829-14|CAC15526.1| 488|Homo sapiens protein ( Human DNA se... 141 5e-33
AL035704-4|CAI22646.1| 1055|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL035704-3|CAI22645.1| 987|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL035704-2|CAI22647.2| 986|Homo sapiens EPH receptor B2 protein. 141 5e-33
AL035704-1|CAI22644.1| 946|Homo sapiens EPH receptor B2 protein. 141 5e-33
AF025304-1|AAB94602.1| 1055|Homo sapiens protein-tyrosine kinase... 141 5e-33
AB210018-1|BAE06100.1| 1004|Homo sapiens EPHB2 variant protein p... 141 5e-33
Z97989-6|CAI22299.1| 485|Homo sapiens FYN oncogene related to S... 140 7e-33
Z97989-5|CAI22301.1| 534|Homo sapiens FYN oncogene related to S... 140 7e-33
D37827-1|BAA07073.1| 478|Homo sapiens large erk/cek5 tyrosine k... 140 7e-33
D31661-1|BAA06506.1| 981|Homo sapiens tyrosine kinase precursor... 140 7e-33
AF037331-1|AAD02030.1| 984|Homo sapiens Eph-like receptor tyros... 140 7e-33
X04434-1|CAA28030.1| 1367|Homo sapiens IGF-I receptor protein. 140 1e-32
M32972-1|AAA59452.1| 1382|Homo sapiens insulin receptor protein. 140 1e-32
M19722-1|AAA52451.1| 529|Homo sapiens FGR protein. 140 1e-32
M10051-1|AAA59174.1| 1382|Homo sapiens INSR protein. 140 1e-32
BC117172-1|AAI17173.1| 1370|Homo sapiens insulin receptor protein. 140 1e-32
BC113612-1|AAI13613.1| 1367|Homo sapiens insulin-like growth fac... 140 1e-32
BC113610-1|AAI13611.1| 1367|Homo sapiens insulin-like growth fac... 140 1e-32
BC064382-1|AAH64382.1| 529|Homo sapiens Gardner-Rasheed feline ... 140 1e-32
AY332722-1|AAP81165.1| 1367|Homo sapiens insulin-like growth fac... 140 1e-32
AL031729-3|CAB62998.1| 529|Homo sapiens Gardner-Rasheed feline ... 140 1e-32
AB208861-1|BAD92098.1| 833|Homo sapiens insulin receptor varian... 140 1e-32
X58741-1|CAA41565.2| 348|Homo sapiens tyrosine kinase protein. 139 2e-32
S74774-1|AAB33113.2| 534|Homo sapiens tyrosine kinase p59fyn(T)... 139 2e-32
M16592-1|AAA52644.1| 505|Homo sapiens HCK protein. 139 2e-32
M16591-1|AAA52643.1| 505|Homo sapiens HCK protein. 139 2e-32
BC114463-1|AAI14464.2| 526|Homo sapiens hemopoietic cell kinase... 139 2e-32
BC108931-1|AAI08932.2| 526|Homo sapiens hemopoietic cell kinase... 139 2e-32
BC108930-1|AAI08931.2| 526|Homo sapiens hemopoietic cell kinase... 139 2e-32
BC101713-1|AAI01714.1| 631|Homo sapiens tec protein tyrosine ki... 139 2e-32
BC101711-1|AAI01712.1| 631|Homo sapiens tec protein tyrosine ki... 139 2e-32
BC094847-1|AAH94847.2| 526|Homo sapiens hemopoietic cell kinase... 139 2e-32
BC014435-1|AAH14435.2| 526|Homo sapiens hemopoietic cell kinase... 139 2e-32
AL353092-2|CAI19694.1| 505|Homo sapiens hemopoietic cell kinase... 139 2e-32
AL353092-1|CAI19695.1| 504|Homo sapiens hemopoietic cell kinase... 139 2e-32
AL049539-2|CAI22967.1| 504|Homo sapiens hemopoietic cell kinase... 139 2e-32
AL049539-1|CAI22966.1| 505|Homo sapiens hemopoietic cell kinase... 139 2e-32
AK026432-1|BAB15482.1| 505|Homo sapiens protein ( Homo sapiens ... 139 2e-32
X02160-1|CAA26096.1| 1370|Homo sapiens protein ( Human mRNA for ... 139 2e-32
X95425-1|CAA64700.1| 1037|Homo sapiens EHK-1 receptor tyrosine k... 138 3e-32
L36644-1|AAA74245.1| 991|Homo sapiens receptor protein-tyrosine... 138 3e-32
AB209375-1|BAD92612.1| 1017|Homo sapiens ephrin receptor EphA5 i... 138 3e-32
Z33998-1|CAA83965.1| 505|Homo sapiens Protein-Tyrosine Kinase p... 138 5e-32
L27071-1|AAA74557.1| 527|Homo sapiens tyrosine kinase protein. 138 5e-32
BC113854-1|AAI13855.2| 504|Homo sapiens HCK protein protein. 137 7e-32
BC032413-1|AAH32413.1| 505|Homo sapiens B lymphoid tyrosine kin... 137 7e-32
BC007371-1|AAH07371.1| 505|Homo sapiens B lymphoid tyrosine kin... 137 7e-32
X58957-1|CAA41728.1| 659|Homo sapiens agammaglobulinaemia tyros... 137 9e-32
U78027-4|AAB64205.1| 659|Homo sapiens Bruton's tyrosine kinase ... 137 9e-32
U13433-1|AAC51347.1| 657|Homo sapiens Bruton's agammaglobulinem... 137 9e-32
U10087-1|AAB60639.1| 659|Homo sapiens Bruton agammaglobulinemia... 137 9e-32
L31572-1|AAA61479.1| 659|Homo sapiens Bruton agammaglobulinemia... 137 9e-32
BC109080-1|AAI09081.1| 659|Homo sapiens Bruton agammaglobulinem... 137 9e-32
BC109079-1|AAI09080.1| 659|Homo sapiens Bruton agammaglobulinem... 137 9e-32
AL035422-3|CAB55876.1| 659|Homo sapiens Bruton agammaglobulinem... 137 9e-32
D14717-1|BAA03537.1| 347|Homo sapiens large erk kinase protein. 136 2e-31
U34379-1|AAB60412.1| 527|Homo sapiens tyrosine kinase protein. 135 3e-31
S76617-1|AAB33265.1| 505|Homo sapiens blk protein. 135 3e-31
L18974-1|AAA16703.1| 527|Homo sapiens tyrosine kinase protein. 135 3e-31
BX537946-1|CAD97914.1| 969|Homo sapiens hypothetical protein pr... 135 3e-31
BC018703-1|AAH18703.1| 599|Homo sapiens Unknown (protein for IM... 135 3e-31
X78549-1|CAA55295.1| 451|Homo sapiens tyrosine kinase protein. 135 4e-31
U61412-1|AAC34935.1| 451|Homo sapiens non-receptor type protein... 135 4e-31
BC035843-1|AAH35843.1| 451|Homo sapiens PTK6 protein tyrosine k... 135 4e-31
AL121829-13|CAC15525.1| 451|Homo sapiens Ptk6 protein. 135 4e-31
L36645-1|AAA74246.1| 986|Homo sapiens receptor protein-tyrosine... 134 5e-31
BC105002-1|AAI05003.1| 986|Homo sapiens ephrin receptor EphA4 p... 134 5e-31
BC105000-1|AAI05001.1| 986|Homo sapiens EPH receptor A4 protein. 134 5e-31
BC026327-1|AAH26327.1| 949|Homo sapiens EPHA4 protein protein. 134 5e-31
AK024281-1|BAB14871.1| 251|Homo sapiens protein ( Homo sapiens ... 134 5e-31
AC010899-2|AAY24284.1| 711|Homo sapiens unknown protein. 134 5e-31
X75208-1|CAA53021.1| 998|Homo sapiens protein tyrosine kinase-r... 134 8e-31
BC052968-1|AAH52968.1| 998|Homo sapiens EPH receptor B3 protein. 134 8e-31
Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus o... 133 1e-30
Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus o... 133 1e-30
M13880-1|AAA36580.1| 494|Homo sapiens protein ( Human mcf3 (rea... 133 1e-30
AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus... 133 1e-30
AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus... 133 1e-30
X16416-1|CAA34438.1| 1130|Homo sapiens protein ( Human c-abl mRN... 133 1e-30
U07563-2|AAB60394.1| 1130|Homo sapiens proto-oncogene tyrosine-p... 133 1e-30
U07563-1|AAB60393.1| 1149|Homo sapiens proto-oncogene tyrosine-p... 133 1e-30
M14752-1|AAA51561.1| 1130|Homo sapiens ABL1 protein. 133 1e-30
J05046-1|AAC31759.1| 1268|Homo sapiens insulin receptor-related ... 133 1e-30
DQ145721-1|AAZ38718.1| 1149|Homo sapiens v-abl Abelson murine le... 133 1e-30
BC117451-1|AAI17452.1| 1149|Homo sapiens v-abl Abelson murine le... 133 1e-30
AL359092-11|CAM45752.1| 1149|Homo sapiens v-abl Abelson murine l... 133 1e-30
AL161733-3|CAM45756.1| 1149|Homo sapiens v-abl Abelson murine le... 133 1e-30
AL161733-1|CAM45754.1| 1130|Homo sapiens v-abl Abelson murine le... 133 1e-30
AL158169-3|CAH70009.1| 1297|Homo sapiens insulin receptor-relate... 133 1e-30
AB209456-1|BAD92693.1| 1167|Homo sapiens v-abl Abelson murine le... 133 1e-30
Z27409-1|CAA81796.1| 691|Homo sapiens receptor tyrosine kinase ... 132 2e-30
U07695-1|AAA20598.1| 987|Homo sapiens tyrosine kinase protein. 132 2e-30
BC130291-1|AAI30292.1| 976|Homo sapiens EPH receptor A1 protein. 132 2e-30
BC052804-1|AAH52804.1| 987|Homo sapiens EPH receptor B4 protein. 132 2e-30
BC004264-1|AAH04264.1| 845|Homo sapiens EPHB4 protein protein. 132 2e-30
AY056048-1|AAL14195.1| 935|Homo sapiens receptor protein tyrosi... 132 2e-30
AY056047-1|AAL14194.1| 987|Homo sapiens receptor protein tyrosi... 132 2e-30
AF312032-8|AAK21010.1| 987|Homo sapiens ephrin type-B receptor ... 132 2e-30
AF101171-1|AAD43440.1| 976|Homo sapiens receptor tyrosine kinas... 132 2e-30
AC092214-2|AAS07458.1| 976|Homo sapiens unknown protein. 132 2e-30
AB209644-1|BAD92881.1| 986|Homo sapiens ephrin receptor EphB4 p... 132 2e-30
DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinas... 132 3e-30
BX470253-1|CAI16293.1| 835|Homo sapiens TNNI3 interacting kinas... 132 3e-30
BC117262-1|AAI17263.1| 835|Homo sapiens TNNI3 interacting kinas... 132 3e-30
BC113539-1|AAI13540.1| 835|Homo sapiens TNNI3 interacting kinas... 132 3e-30
AY303691-1|AAP72030.1| 835|Homo sapiens cardiac ankyrin repeat ... 132 3e-30
AF116826-1|AAD29632.1| 835|Homo sapiens putative protein-tyrosi... 132 3e-30
AB208941-1|BAD92178.1| 941|Homo sapiens TNNI3 interacting kinas... 132 3e-30
M34353-1|AAA60278.1| 2347|Homo sapiens ROS1 protein. 132 3e-30
BC032496-1|AAH32496.1| 482|Homo sapiens FYN oncogene related to... 132 3e-30
M35296-1|AAA35553.1| 1182|Homo sapiens protein ( Human tyrosine ... 130 8e-30
DQ009672-1|AAY16984.1| 1182|Homo sapiens v-abl Abelson murine le... 130 8e-30
BX538317-1|CAD98092.1| 1092|Homo sapiens hypothetical protein pr... 130 8e-30
BC065912-1|AAH65912.1| 1167|Homo sapiens ABL2 protein protein. 130 8e-30
AL512326-6|CAI13570.1| 1182|Homo sapiens v-abl Abelson murine le... 130 8e-30
AL512326-2|CAI13566.1| 1064|Homo sapiens v-abl Abelson murine le... 130 8e-30
AL359179-2|CAI15585.1| 1182|Homo sapiens v-abl Abelson murine le... 130 8e-30
AL359179-1|CAI15584.1| 1064|Homo sapiens v-abl Abelson murine le... 130 8e-30
AL139132-5|CAH70925.1| 1182|Homo sapiens v-abl Abelson murine le... 130 8e-30
AL139132-1|CAH70921.1| 1064|Homo sapiens v-abl Abelson murine le... 130 8e-30
M18391-1|AAA36747.1| 984|Homo sapiens protein ( Human tyrosine ... 130 1e-29
AJ865079-1|CAI23831.1| 516|Homo sapiens proto-oncogene tyrosine... 127 7e-29
BC109099-1|AAI09100.1| 773|Homo sapiens MUSK protein protein. 127 1e-28
BC109098-1|AAI09099.1| 783|Homo sapiens MUSK protein protein. 127 1e-28
AL513328-2|CAI17350.1| 867|Homo sapiens muscle, skeletal, recep... 127 1e-28
AL513328-1|CAI17349.1| 875|Homo sapiens muscle, skeletal, recep... 127 1e-28
AL157881-3|CAH69978.1| 867|Homo sapiens muscle, skeletal, recep... 127 1e-28
AL157881-2|CAH69977.1| 875|Homo sapiens muscle, skeletal, recep... 127 1e-28
AF006464-1|AAB63044.1| 869|Homo sapiens muscle specific tyrosin... 127 1e-28
M97639-1|AAA60276.1| 943|Homo sapiens transmembrane receptor pr... 126 1e-28
L13616-1|AAA58469.1| 1052|Homo sapiens focal adhesion kinase pro... 126 1e-28
BC130522-1|AAI30523.1| 943|Homo sapiens receptor tyrosine kinas... 126 1e-28
BC035404-1|AAH35404.1| 1006|Homo sapiens PTK2 protein protein. 126 1e-28
BC028733-1|AAH28733.1| 680|Homo sapiens PTK2 protein protein. 126 1e-28
AL928802-2|CAI17303.1| 943|Homo sapiens receptor tyrosine kinas... 126 1e-28
AL928802-1|CAI17302.1| 704|Homo sapiens receptor tyrosine kinas... 126 1e-28
AL591214-1|CAH71099.1| 704|Homo sapiens receptor tyrosine kinas... 126 1e-28
AL583841-2|CAI15694.1| 943|Homo sapiens receptor tyrosine kinas... 126 1e-28
AL583841-1|CAI15693.1| 704|Homo sapiens receptor tyrosine kinas... 126 1e-28
AL391219-1|CAH70208.1| 943|Homo sapiens receptor tyrosine kinas... 126 1e-28
AF294796-1|AAG01184.2| 910|Homo sapiens ROR2 protein protein. 126 1e-28
AB209154-1|BAD92391.1| 919|Homo sapiens Tyrosine-protein kinase... 126 1e-28
AK094999-1|BAC04470.1| 720|Homo sapiens protein ( Homo sapiens ... 126 2e-28
AB209642-1|BAD92879.1| 949|Homo sapiens Proto-oncogene tyrosine... 126 2e-28
AB209083-1|BAD92320.1| 1007|Homo sapiens PTK2 protein tyrosine k... 126 2e-28
AB209071-1|BAD92308.1| 975|Homo sapiens PTK2 protein tyrosine k... 126 2e-28
X85960-1|CAA59936.1| 591|Homo sapiens p68 TRK-T3 oncoprotein pr... 125 3e-28
X74765-1|CAB58562.1| 450|Homo sapiens protein tyrosine kinase p... 125 3e-28
X60114-1|CAA42713.1| 450|Homo sapiens put. cytoplasmic tyrosine... 125 3e-28
X59932-1|CAA42556.1| 450|Homo sapiens c-src-kinase protein. 125 3e-28
DQ075211-1|AAY57329.1| 450|Homo sapiens c-src tyrosine kinase p... 125 3e-28
CR541960-1|CAG46758.1| 450|Homo sapiens CSK protein. 125 3e-28
BC106073-1|AAI06074.1| 450|Homo sapiens c-src tyrosine kinase p... 125 3e-28
BC104875-1|AAI04876.1| 450|Homo sapiens c-src tyrosine kinase p... 125 3e-28
BC104847-1|AAI04848.1| 450|Homo sapiens c-src tyrosine kinase p... 125 3e-28
U40271-1|AAC50484.2| 1070|Homo sapiens transmembrane receptor pr... 125 4e-28
BC071557-1|AAH71557.1| 1070|Homo sapiens PTK7 protein tyrosine k... 125 4e-28
AL355385-4|CAI13783.1| 1070|Homo sapiens PTK7 protein tyrosine k... 125 4e-28
AK223626-1|BAD97346.1| 449|Homo sapiens c-src tyrosine kinase v... 125 4e-28
AF531871-1|AAN04865.1| 1014|Homo sapiens transmembrane receptor ... 125 4e-28
AF531870-1|AAN04864.1| 940|Homo sapiens transmembrane receptor ... 125 4e-28
AF531869-1|AAN04863.1| 1030|Homo sapiens transmembrane receptor ... 125 4e-28
AF531868-1|AAN04862.1| 1070|Homo sapiens transmembrane receptor ... 125 4e-28
AF447176-1|AAL39062.1| 1070|Homo sapiens protein tyrosine kinase... 125 4e-28
U12140-1|AAC51371.1| 822|Homo sapiens tyrosine kinase receptor ... 124 7e-28
S76473-1|AAB33109.1| 822|Homo sapiens trkB protein. 124 7e-28
BC032865-1|AAH32865.1| 843|Homo sapiens TNNI3K protein protein. 124 7e-28
AL596132-4|CAH72315.1| 822|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AL596132-3|CAH72316.1| 838|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AL445532-2|CAH71817.1| 822|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AL445532-1|CAH71816.1| 838|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AL390777-4|CAH72196.1| 822|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AL390777-3|CAH72195.1| 838|Homo sapiens neurotrophic tyrosine k... 124 7e-28
AF410899-1|AAL67965.1| 838|Homo sapiens neurotrophin receptor t... 124 7e-28
AF400441-1|AAK92490.1| 822|Homo sapiens neurotrophic tyrosine k... 124 7e-28
X62947-1|CAA44719.1| 503|Homo sapiens 55 kd protein protein. 124 9e-28
M23102-1|AAA36770.1| 790|Homo sapiens protein ( Human trk proto... 124 9e-28
BC062580-1|AAH62580.1| 795|Homo sapiens NTRK1 protein protein. 124 9e-28
AL158169-4|CAH70010.1| 790|Homo sapiens neurotrophic tyrosine k... 124 9e-28
AL157486-1|CAB75674.1| 364|Homo sapiens hypothetical protein pr... 124 9e-28
AB019488-1|BAA34355.1| 796|Homo sapiens TRKA protein. 124 9e-28
X60957-1|CAA43290.1| 1138|Homo sapiens receptor tyrosine kinase ... 123 1e-27
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 123 1e-27
BC038239-1|AAH38239.1| 1138|Homo sapiens tyrosine kinase with im... 123 1e-27
AL139289-10|CAI23385.1| 1138|Homo sapiens tyrosine kinase with i... 123 1e-27
AL139289-9|CAI23386.1| 541|Homo sapiens tyrosine kinase with im... 123 1e-27
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 123 1e-27
AF217976-1|AAG17219.1| 421|Homo sapiens unknown protein. 123 1e-27
M13599-1|AAA60277.1| 471|Homo sapiens ROS1 protein. 122 4e-27
L05186-1|AAA35819.1| 879|Homo sapiens focal adhesion kinase pro... 122 4e-27
M14209-1|AAA52441.1| 211|Homo sapiens fes/fps proto-oncogene pr... 121 5e-27
AY574904-1|AAT81413.1| 510|Homo sapiens regulated in COPD kinas... 121 6e-27
AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinas... 121 6e-27
AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinas... 121 6e-27
Z71929-1|CAA96492.1| 821|Homo sapiens FGFR2 protein. 120 8e-27
X56191-1|CAA39654.1| 769|Homo sapiens fibroblast growth factor ... 120 8e-27
X52832-1|CAA37014.1| 821|Homo sapiens protein ( Human bek mRNA ... 120 8e-27
X06704-1|CAA29888.1| 439|Homo sapiens protein ( Human mRNA for ... 120 8e-27
X03541-1|CAA27243.1| 641|Homo sapiens protein ( Human mRNA of t... 120 8e-27
U33635-1|AAA87565.1| 1070|Homo sapiens colon carcinoma kinase-4 ... 120 8e-27
M97193-1|AAA52449.1| 822|Homo sapiens fibroblast growth factor ... 120 8e-27
M87771-1|AAA59471.1| 705|Homo sapiens fibroblast growth factor ... 120 8e-27
M87770-1|AAA59470.1| 821|Homo sapiens fibroblast growth factor ... 120 8e-27
M55614-1|AAA61188.1| 822|Homo sapiens TK14 protein protein. 120 8e-27
M35718-1|AAA36152.1| 682|Homo sapiens protein ( Human heparin-b... 120 8e-27
DQ493927-1|ABE96832.1| 785|Homo sapiens fibroblast growth facto... 120 8e-27
BC039243-1|AAH39243.2| 704|Homo sapiens FGFR2 protein protein. 120 8e-27
AM051276-1|CAJ19682.1| 319|Homo sapiens dominant-negative kinas... 120 8e-27
AF487553-1|AAM74056.1| 822|Homo sapiens fibroblast growth facto... 120 8e-27
AF360695-4|AAK94208.1| 766|Homo sapiens keratinocyte growth fac... 120 8e-27
AF360695-3|AAK94209.1| 785|Homo sapiens keratinocyte growth fac... 120 8e-27
AF360695-2|AAK94205.1| 819|Homo sapiens keratinocyte growth fac... 120 8e-27
AF360695-1|AAK94206.1| 820|Homo sapiens keratinocyte growth fac... 120 8e-27
AF097353-2|AAD31561.1| 554|Homo sapiens fibroblast growth facto... 120 8e-27
AF097353-1|AAD31560.1| 555|Homo sapiens fibroblast growth recep... 120 8e-27
AF037333-1|AAB94627.1| 943|Homo sapiens Eph-like receptor tyros... 120 8e-27
AB084153-1|BAC45037.1| 709|Homo sapiens isoform of FGFR2 protein. 120 8e-27
BC014243-1|AAH14243.1| 1187|Homo sapiens tyrosine kinase 2 protein. 120 1e-26
U66559-1|AAC51104.1| 1620|Homo sapiens anaplastic lymphoma kinas... 119 2e-26
U62540-1|AAB71619.1| 1620|Homo sapiens anaplastic lymphoma kinas... 119 2e-26
U04946-1|AAA58698.1| 680|Homo sapiens nucleophosmin-anaplastic ... 119 2e-26
D45915-1|BAA08343.1| 680|Homo sapiens p80 protein protein. 119 2e-26
AF390893-1|AAM17922.1| 803|Homo sapiens TRK-fused gene/anaplast... 119 2e-26
AF143407-1|AAF27292.1| 756|Homo sapiens TRK-fused gene/anaplast... 119 2e-26
AF125093-1|AAF42734.1| 701|Homo sapiens TRK-fused gene-anaplast... 119 2e-26
AC074096-1|AAY15027.1| 1192|Homo sapiens unknown protein. 119 2e-26
AB209477-1|BAD92714.1| 1626|Homo sapiens anaplastic lymphoma kin... 119 2e-26
BC039695-1|AAH39695.1| 1129|Homo sapiens JAK2 protein protein. 118 3e-26
BC008655-1|AAH08655.1| 253|Homo sapiens EPHA2 protein protein. 118 3e-26
AY973034-1|AAY22962.1| 1132|Homo sapiens Janus kinase 2 protein. 118 3e-26
AY549314-1|AAS37680.1| 1187|Homo sapiens tyrosine kinase 2 protein. 118 3e-26
AL161450-1|CAD13329.1| 1132|Homo sapiens Janus kinase 2 (a prote... 118 3e-26
AF058925-1|AAC23982.1| 1132|Homo sapiens Jak2 kinase protein. 118 3e-26
AF005216-1|AAB82092.1| 1132|Homo sapiens receptor-associated tyr... 118 3e-26
AF001362-1|AAC23653.1| 1132|Homo sapiens Jak2 kinase protein. 118 3e-26
X54637-1|CAA38449.1| 1187|Homo sapiens protein ( Human tyk2 mRNA... 118 4e-26
Y00665-1|CAA68679.1| 622|Homo sapiens tyrosine kinase protein. 118 6e-26
X66945-1|CAA47375.1| 822|Homo sapiens fibroblast growth factor ... 118 6e-26
X57122-1|CAA40404.1| 731|Homo sapiens Fibroblast Growth Factor ... 118 6e-26
X57121-1|CAA40403.1| 822|Homo sapiens Fibroblast Growth Factor ... 118 6e-26
X57120-1|CAA40402.1| 820|Homo sapiens Fibroblast Growth Factor ... 118 6e-26
X57119-1|CAA40401.1| 733|Homo sapiens Fibroblast Growth Factor ... 118 6e-26
X52833-1|CAA37015.1| 822|Homo sapiens protein ( Human flg mRNA ... 118 6e-26
X51803-1|CAA36101.1| 822|Homo sapiens protein ( Human mRNA for ... 118 6e-26
M63887-1|AAA35958.1| 822|Homo sapiens heparin-binding growth fa... 118 6e-26
M60485-1|AAA35840.1| 820|Homo sapiens fibroblast growth factor ... 118 6e-26
M37722-1|AAA75007.1| 731|Homo sapiens basic fibroblast growth f... 118 6e-26
M34641-1|AAA35835.1| 820|Homo sapiens protein ( Human fibroblas... 118 6e-26
M34186-1|AAA35837.1| 731|Homo sapiens protein ( Human fibroblas... 118 6e-26
M34185-1|AAA35836.1| 733|Homo sapiens protein ( Human fibroblas... 118 6e-26
BC091494-1|AAH91494.1| 731|Homo sapiens fibroblast growth facto... 118 6e-26
BC018128-1|AAH18128.1| 820|Homo sapiens fibroblast growth facto... 118 6e-26
BC015035-1|AAH15035.1| 820|Homo sapiens FGFR1 protein protein. 118 6e-26
AY585209-1|AAS79322.1| 822|Homo sapiens fibroblast growth facto... 118 6e-26
AK222718-1|BAD96438.1| 820|Homo sapiens fibroblast growth facto... 118 6e-26
AK131215-1|BAD18404.1| 543|Homo sapiens protein ( Homo sapiens ... 118 6e-26
AJ872185-1|CAI43321.1| 1008|Homo sapiens Ephrin type-A receptor ... 118 6e-26
AB208919-1|BAD92156.1| 814|Homo sapiens fibroblast growth facto... 118 6e-26
X70040-1|CAA49634.1| 1400|Homo sapiens tyrosine kinase protein. 117 8e-26
L07868-1|AAB59446.1| 1308|Homo sapiens receptor tyrosine kinase ... 117 8e-26
BC112199-1|AAI12200.1| 1308|Homo sapiens v-erb-a erythroblastic ... 117 8e-26
AB209697-1|BAD92934.1| 892|Homo sapiens v-erb-a erythroblastic ... 117 8e-26
U43522-1|AAC05330.1| 1009|Homo sapiens cell adhesion kinase beta... 117 1e-25
BC099843-1|AAH99843.1| 416|Homo sapiens serine/threonine protei... 117 1e-25
U33284-1|AAC50203.1| 1009|Homo sapiens PYK2 protein. 116 1e-25
S80542-1|AAB35701.1| 1009|Homo sapiens related adhesion focal ty... 116 1e-25
L49207-1|AAB47217.1| 1009|Homo sapiens focal adhesion kinase pro... 116 1e-25
BC042599-1|AAH42599.1| 1009|Homo sapiens PTK2B protein tyrosine ... 116 1e-25
BC036651-1|AAH36651.1| 1009|Homo sapiens PTK2B protein tyrosine ... 116 1e-25
AK128371-1|BAC87404.1| 596|Homo sapiens protein ( Homo sapiens ... 116 1e-25
AB209085-1|BAD92322.1| 802|Homo sapiens PTK2B protein tyrosine ... 116 1e-25
X54559-1|CAB56793.1| 1390|Homo sapiens proto-oncogene protein. 116 2e-25
L06139-1|AAA61139.1| 1124|Homo sapiens receptor protein-tyrosine... 116 2e-25
AL133411-1|CAI16055.1| 1124|Homo sapiens TEK tyrosine kinase, en... 116 2e-25
AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens ... 116 2e-25
AB208796-1|BAD92033.1| 1157|Homo sapiens TEK tyrosine kinase var... 116 2e-25
Z29630-1|CAA82737.1| 612|Homo sapiens protein-tyrosine kinase p... 116 2e-25
X73568-1|CAA51970.1| 630|Homo sapiens protein tyrosin kinase pr... 116 2e-25
L28824-1|AAA36526.1| 635|Homo sapiens protein tyrosine kinase p... 116 2e-25
BC011399-1|AAH11399.1| 612|Homo sapiens SYK protein protein. 116 2e-25
BC002962-1|AAH02962.1| 635|Homo sapiens spleen tyrosine kinase ... 116 2e-25
BC001645-1|AAH01645.1| 635|Homo sapiens spleen tyrosine kinase ... 116 2e-25
AL354862-3|CAI16875.1| 612|Homo sapiens spleen tyrosine kinase ... 116 2e-25
AL354862-2|CAI16876.1| 635|Homo sapiens spleen tyrosine kinase ... 116 2e-25
U67156-1|AAC50894.1| 1374|Homo sapiens mitogen-activated kinase ... 115 3e-25
D84476-1|BAA12684.2| 1374|Homo sapiens apoptosis signal-regulati... 115 3e-25
BT020099-1|AAV38902.1| 416|Homo sapiens Mst3 and SOK1-related k... 115 3e-25
BC103503-1|AAI03504.1| 416|Homo sapiens serine/threonine protei... 115 3e-25
BC098315-1|AAH98315.1| 416|Homo sapiens serine/threonine protei... 115 3e-25
BC088829-1|AAH88829.1| 1374|Homo sapiens mitogen-activated prote... 115 3e-25
BC054503-1|AAH54503.1| 1374|Homo sapiens mitogen-activated prote... 115 3e-25
AL121933-1|CAI15470.1| 1374|Homo sapiens mitogen-activated prote... 115 3e-25
AL109749-1|CAI42079.1| 416|Homo sapiens Mst3 and SOK1-related k... 115 3e-25
AL024508-2|CAI20176.1| 1374|Homo sapiens mitogen-activated prote... 115 3e-25
AK075150-1|BAC11435.1| 392|Homo sapiens protein ( Homo sapiens ... 115 3e-25
AF344882-1|AAK29620.1| 416|Homo sapiens serine/threonine protei... 115 3e-25
AF231012-1|AAK38484.1| 416|Homo sapiens STE20-like kinase MST4 ... 115 3e-25
AB209093-1|BAD92330.1| 1455|Homo sapiens mitogen-activated prote... 115 3e-25
AB040057-1|BAA92785.2| 416|Homo sapiens serine/threonine protei... 115 3e-25
U19348-1|AAA92686.1| 523|Homo sapiens tpr-met fusion protein pr... 115 4e-25
U08818-1|AAB60323.1| 455|Homo sapiens activated met oncogene pr... 115 4e-25
BC130420-1|AAI30421.1| 1390|Homo sapiens met proto-oncogene (hep... 115 4e-25
BC129951-1|AAI29952.1| 854|Homo sapiens MAP3K6 protein protein. 115 4e-25
BC129950-1|AAI29951.1| 854|Homo sapiens MAP3K6 protein protein. 115 4e-25
BC109032-1|AAI09033.1| 441|Homo sapiens MAP3K6 protein protein. 115 4e-25
BC015914-1|AAH15914.1| 797|Homo sapiens MAP3K6 protein protein. 115 4e-25
AL663123-5|CAI14778.1| 797|Homo sapiens mitogen-activated prote... 115 4e-25
AL663123-4|CAM12869.1| 1288|Homo sapiens mitogen-activated prote... 115 4e-25
AF100318-1|AAD05304.1| 1011|Homo sapiens mitogen-activated prote... 115 4e-25
AB209898-1|BAD93135.1| 712|Homo sapiens met proto-oncogene prec... 115 4e-25
AB208805-1|BAD92042.1| 1192|Homo sapiens mitogen-activated prote... 115 4e-25
AB167411-1|BAD12485.1| 1288|Homo sapiens apoptosis signal-regula... 115 4e-25
AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein ki... 115 4e-25
BC015515-1|AAH15515.1| 451|Homo sapiens Unknown (protein for IM... 114 5e-25
BC114918-1|AAI14919.1| 823|Homo sapiens MERTK protein protein. 114 7e-25
BC114917-1|AAI14918.1| 823|Homo sapiens MERTK protein protein. 114 7e-25
AL732423-2|CAM17479.1| 748|Homo sapiens mitogen-activated prote... 114 7e-25
AL732423-1|CAM17478.1| 788|Homo sapiens mitogen-activated prote... 114 7e-25
AL732326-2|CAM23143.1| 788|Homo sapiens mitogen-activated prote... 114 7e-25
AL732326-1|CAM23142.1| 748|Homo sapiens mitogen-activated prote... 114 7e-25
AK131412-1|BAD18559.1| 748|Homo sapiens protein ( Homo sapiens ... 114 7e-25
AF260529-1|AAG33129.1| 978|Homo sapiens MER receptor tyrosine k... 114 7e-25
AC093675-1|AAY24213.1| 567|Homo sapiens unknown protein. 114 7e-25
U43586-1|AAC50354.1| 635|Homo sapiens KSR1 protein. 113 1e-24
U08023-1|AAB60430.1| 999|Homo sapiens c-mer protein. 113 1e-24
J02958-1|AAA59591.1| 1408|Homo sapiens MET protein. 113 1e-24
BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis ... 113 1e-24
AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis ... 113 1e-24
D83492-1|BAA21560.1| 1006|Homo sapiens Eph-family protein protein. 113 2e-24
BC110607-1|AAI10608.2| 1006|Homo sapiens EPH receptor B6 protein. 113 2e-24
BC110606-1|AAI10607.1| 729|Homo sapiens EPHB6 protein protein. 113 2e-24
BC013200-1|AAH13200.1| 539|Homo sapiens LCK protein protein. 113 2e-24
AY280502-1|AAP20939.1| 1006|Homo sapiens EPHB6 protein. 113 2e-24
AL121991-3|CAI22321.1| 526|Homo sapiens lymphocyte-specific pro... 113 2e-24
L13738-1|AAA53570.2| 1036|Homo sapiens activated p21cdc42Hs kina... 112 2e-24
BC028164-1|AAH28164.1| 528|Homo sapiens TNK2 protein protein. 112 2e-24
AK131539-1|BAD18675.1| 1086|Homo sapiens protein ( Homo sapiens ... 112 2e-24
AB209338-1|BAD92575.1| 400|Homo sapiens Hypothetical protein FL... 112 2e-24
BC112933-1|AAI12934.1| 387|Homo sapiens Unknown (protein for MG... 112 3e-24
BC053878-1|AAH53878.1| 619|Homo sapiens zeta-chain (TCR) associ... 112 3e-24
BC039039-1|AAH39039.1| 493|Homo sapiens ZAP70 protein protein. 112 3e-24
AC016699-1|AAX93187.1| 493|Homo sapiens unknown protein. 112 3e-24
AB083211-1|BAC43747.1| 312|Homo sapiens truncated ZAP kinase pr... 112 3e-24
U24153-1|AAA65442.1| 525|Homo sapiens p21-activated protein kin... 111 4e-24
AK131477-1|BAD18622.1| 788|Homo sapiens protein ( Homo sapiens ... 111 4e-24
X57019-1|CAA40338.1| 894|Homo sapiens protein ( H.sapiens mRNA ... 111 5e-24
S65125-1|AAB20305.1| 894|Homo sapiens UFO protein. 111 5e-24
L20321-1|AAA36658.1| 841|Homo sapiens protein serine/threonine ... 111 5e-24
BC063044-1|AAH63044.1| 781|Homo sapiens NEK4 protein protein. 111 5e-24
BC028587-1|AAH28587.1| 482|Homo sapiens NEK11 protein protein. 111 5e-24
AB071997-1|BAC06351.1| 470|Homo sapiens NIMA-related kinase 11S... 111 5e-24
AB071996-1|BAC06350.1| 645|Homo sapiens NIMA-related kinase 11L... 111 5e-24
>U07358-1|AAA67343.1| 859|Homo sapiens serine/threonine protein
kinase protein.
Length = 859
Score = 415 bits (1022), Expect = e-115
Identities = 199/360 (55%), Positives = 258/360 (71%), Gaps = 2/360 (0%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
E+ WEVPFE I D+ ++GSGAQG V+ G GE VAVKK+R+ +ETDI HLRKL H NI+
Sbjct: 115 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNII 174
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCI+MEFC G LY+ L +G TP ++ W+ IA GM YLH KIIH
Sbjct: 175 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 234
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ + V K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 235 RDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 294
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP+SCP+ K+LL QCW+ PRNR
Sbjct: 295 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 354
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ IL HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 355 PSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMR 414
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRC-GLRK 364
RREELR A D R YE++L RAN LYME+ A+ LQLE KE+ L RE+AL+ RC GL K
Sbjct: 415 RREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER-RCPGLLK 473
>BC050050-1|AAH50050.1| 567|Homo sapiens MAP3K12 protein protein.
Length = 567
Score = 415 bits (1022), Expect = e-115
Identities = 199/360 (55%), Positives = 258/360 (71%), Gaps = 2/360 (0%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
E+ WEVPFE I D+ ++GSGAQG V+ G GE VAVKK+R+ +ETDI HLRKL H NI+
Sbjct: 148 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNII 207
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCI+MEFC G LY+ L +G TP ++ W+ IA GM YLH KIIH
Sbjct: 208 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 267
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ + V K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 268 RDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 327
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP+SCP+ K+LL QCW+ PRNR
Sbjct: 328 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 387
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ IL HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 388 PSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMR 447
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRC-GLRK 364
RREELR A D R YE++L RAN LYME+ A+ LQLE KE+ L RE+AL+ RC GL K
Sbjct: 448 RREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER-RCPGLLK 506
>AF283475-1|AAL67158.1| 859|Homo sapiens zipper protein kinase
protein.
Length = 859
Score = 415 bits (1022), Expect = e-115
Identities = 199/360 (55%), Positives = 258/360 (71%), Gaps = 2/360 (0%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
E+ WEVPFE I D+ ++GSGAQG V+ G GE VAVKK+R+ +ETDI HLRKL H NI+
Sbjct: 115 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNII 174
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCI+MEFC G LY+ L +G TP ++ W+ IA GM YLH KIIH
Sbjct: 175 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 234
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ + V K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 235 RDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 294
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP+SCP+ K+LL QCW+ PRNR
Sbjct: 295 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 354
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ IL HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 355 PSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMR 414
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRC-GLRK 364
RREELR A D R YE++L RAN LYME+ A+ LQLE KE+ L RE+AL+ RC GL K
Sbjct: 415 RREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER-RCPGLLK 473
>AB001872-1|BAA24817.1| 966|Homo sapiens leucine zipper bearing
kinase protein.
Length = 966
Score = 414 bits (1020), Expect = e-115
Identities = 190/351 (54%), Positives = 252/351 (71%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
++ WEVPFE I+++ +LGSGAQG V+ G R E VA+KK+RE+ ETDI HLRKL H NI+
Sbjct: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNII 217
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCIIME+C +G LY+ L +G TPR ++ W+ IA GM YLH KIIH
Sbjct: 218 AFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIH 277
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPNVLV K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 278 RDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 337
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP++CP+ K+L+ Q W PRNR
Sbjct: 338 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNR 397
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ L HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 398 PSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRR 457
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALK 356
RREELR A D R YE++L RAN LYME+ A+ LQLE +EK L +RE+A++
Sbjct: 458 RREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVE 508
>BC064543-1|AAH64543.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 protein.
Length = 847
Score = 226 bits (552), Expect = 1e-58
Identities = 130/359 (36%), Positives = 194/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLVADNLVA--------KVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ ++ + K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQHIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>U07747-1|AAA19647.1| 847|Homo sapiens serine/threonine protein
kinase protein.
Length = 847
Score = 225 bits (551), Expect = 2e-58
Identities = 131/359 (36%), Positives = 195/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLV-----ADNL---VAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ +D++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQPIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>L32976-1|AAA59859.1| 847|Homo sapiens protein kinase protein.
Length = 847
Score = 225 bits (551), Expect = 2e-58
Identities = 131/359 (36%), Positives = 195/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLV-----ADNL---VAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ +D++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQPIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>BC011263-1|AAH11263.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 protein.
Length = 847
Score = 225 bits (551), Expect = 2e-58
Identities = 131/359 (36%), Positives = 195/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLV-----ADNL---VAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ +D++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQPIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>AK222781-1|BAD96501.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 variant protein.
Length = 847
Score = 225 bits (551), Expect = 2e-58
Identities = 131/359 (36%), Positives = 195/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLV-----ADNL---VAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ +D++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQPIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>Z48615-1|CAA88531.1| 953|Homo sapiens serine/threonine kinase with
SH3 domain, leucine zipper domain and proline rich
protein.
Length = 953
Score = 223 bits (545), Expect = 1e-57
Identities = 142/378 (37%), Positives = 199/378 (52%), Gaps = 43/378 (11%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD--------IMHLR---K 58
E+PF + +G G G VY RGE VAVK R E D R
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RG C + C++ME+ + G L L +G P ++ WA +A+GM YL
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
Query: 119 HNRK---IIHRDLKSPNVLVAD-----NL---VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN IIHRDLKS N+L+ + NL V K++DFG +REW +++ MS GT AW
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW-HKTTKMSAAGTYAW 269
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CP
Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMK 286
E LL +CWD P RP F IL L++ +P + F Q W+ EI++
Sbjct: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
Query: 287 EIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
++ T+ KE L+S E LR A++ R E+QL R + +L ++E
Sbjct: 390 DLRTKEKE-------LRSREEELLRAAQEQR-FQEEQLRRREQ----------ELAEREM 431
Query: 347 HLDEREKALKLCRCGLRK 364
+ ERE L +C+ K
Sbjct: 432 DIVERELHLLMCQLSQEK 449
>X90846-1|CAA62351.1| 954|Homo sapiens mixed lineage kinase 2
protein.
Length = 954
Score = 223 bits (545), Expect = 1e-57
Identities = 142/378 (37%), Positives = 199/378 (52%), Gaps = 43/378 (11%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD--------IMHLR---K 58
E+PF + +G G G VY RGE VAVK R E D R
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RG C + C++ME+ + G L L +G P ++ WA +A+GM YL
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
Query: 119 HNRK---IIHRDLKSPNVLVAD-----NL---VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN IIHRDLKS N+L+ + NL V K++DFG +REW +++ MS GT AW
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW-HKTTKMSAAGTYAW 269
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CP
Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMK 286
E LL +CWD P RP F IL L++ +P + F Q W+ EI++
Sbjct: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
Query: 287 EIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
++ T+ KE L+S E LR A++ R E+QL R + +L ++E
Sbjct: 390 DLRTKEKE-------LRSREEELLRAAQEQR-FQEEQLRRREQ----------ELAEREM 431
Query: 347 HLDEREKALKLCRCGLRK 364
+ ERE L +C+ K
Sbjct: 432 DIVERELHLLMCQLSQEK 449
>BC111726-1|AAI11727.1| 656|Homo sapiens MAP3K13 protein protein.
Length = 656
Score = 223 bits (544), Expect = 1e-57
Identities = 104/198 (52%), Positives = 141/198 (71%)
Query: 159 MSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETI 218
MSF GTVAWMAPEVIR+EP SE+VD+WSFGVVLWELLT EIPYK +++ AI+WGVG+ ++
Sbjct: 1 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 60
Query: 219 LLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWR 278
LPVP++CP+ K+L+ Q W PRNRP F+ L HLDIA A+ + + +QA WR
Sbjct: 61 HLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWR 120
Query: 279 KEIENEMKEIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVR 338
+E++ ++I + ++L RREELR A D R YE++L RAN LYME+ A+
Sbjct: 121 EEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIM 180
Query: 339 LQLEQKEKHLDEREKALK 356
LQLE +EK L +RE+A++
Sbjct: 181 LQLEMREKELIKREQAVE 198
>AY327900-1|AAQ23054.1| 1104|Homo sapiens mixed-lineage protein
kinase 1 protein.
Length = 1104
Score = 216 bits (527), Expect = 2e-55
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 256
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 315
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 316 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 375
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 376 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQETFD 435
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 436 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 491
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 492 CQEKPRVKKRKGKFRKSRLKLK 513
>BC133706-1|AAI33707.1| 1104|Homo sapiens MAP3K9 protein protein.
Length = 1104
Score = 215 bits (526), Expect = 2e-55
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 256
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 315
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 316 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 375
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 376 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 435
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 436 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 491
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 492 CQEKPRVKKRKGKFRKSRLKLK 513
>BC111407-1|AAI11408.1| 1103|Homo sapiens MAP3K9 protein protein.
Length = 1103
Score = 215 bits (526), Expect = 2e-55
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 137 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 196
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 197 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 255
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 256 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 314
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 315 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 374
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 375 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 434
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 435 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 490
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 491 CQEKPRVKKRKGKFRKSRLKLK 512
>AF251442-1|AAG44591.1| 1066|Homo sapiens mixed lineage kinase MLK1
protein.
Length = 1066
Score = 215 bits (526), Expect = 2e-55
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 86 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 145
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 146 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 204
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 205 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 263
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 264 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 323
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 324 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 383
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 384 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 439
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 440 CQEKPRVKKRKGKFRKSRLKLK 461
>BC001401-1|AAH01401.1| 455|Homo sapiens sterile alpha motif and
leucine zipper containing kinase AZK protein.
Length = 455
Score = 215 bits (524), Expect = 4e-55
Identities = 139/364 (38%), Positives = 208/364 (57%), Gaps = 28/364 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE + E+ ++
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATL--------ERLKK 296
Query: 299 AQKLQSVRREELRLARDTRL-IYEQQLS-RANELYMEVCAVRLQLEQK-EKHLDEREKAL 355
++ S + +EL+ R+ RL ++EQ+L+ ++N + A R+ E E +E A
Sbjct: 297 LERDLSFKEQELK-ERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAE 355
Query: 356 KLCR 359
C+
Sbjct: 356 MSCQ 359
>AF480462-1|AAL85892.1| 455|Homo sapiens mixed lineage
kinase-related kinase MRK-beta protein.
Length = 455
Score = 215 bits (524), Expect = 4e-55
Identities = 139/364 (38%), Positives = 208/364 (57%), Gaps = 28/364 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE + E+ ++
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATL--------ERLKK 296
Query: 299 AQKLQSVRREELRLARDTRL-IYEQQLS-RANELYMEVCAVRLQLEQK-EKHLDEREKAL 355
++ S + +EL+ R+ RL ++EQ+L+ ++N + A R+ E E +E A
Sbjct: 297 LERDLSFKEQELK-ERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAE 355
Query: 356 KLCR 359
C+
Sbjct: 356 MSCQ 359
>AF325454-1|AAK11615.1| 455|Homo sapiens mixed lineage kinase
protein.
Length = 455
Score = 215 bits (524), Expect = 4e-55
Identities = 139/364 (38%), Positives = 208/364 (57%), Gaps = 28/364 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE + E+ ++
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATL--------ERLKK 296
Query: 299 AQKLQSVRREELRLARDTRL-IYEQQLS-RANELYMEVCAVRLQLEQK-EKHLDEREKAL 355
++ S + +EL+ R+ RL ++EQ+L+ ++N + A R+ E E +E A
Sbjct: 297 LERDLSFKEQELK-ERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAE 355
Query: 356 KLCR 359
C+
Sbjct: 356 MSCQ 359
>AB049734-1|BAB16445.1| 455|Homo sapiens MLTK-beta protein.
Length = 455
Score = 215 bits (524), Expect = 4e-55
Identities = 139/364 (38%), Positives = 208/364 (57%), Gaps = 28/364 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE + E+ ++
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATL--------ERLKK 296
Query: 299 AQKLQSVRREELRLARDTRL-IYEQQLS-RANELYMEVCAVRLQLEQK-EKHLDEREKAL 355
++ S + +EL+ R+ RL ++EQ+L+ ++N + A R+ E E +E A
Sbjct: 297 LERDLSFKEQELK-ERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAE 355
Query: 356 KLCR 359
C+
Sbjct: 356 MSCQ 359
>AF480461-1|AAL85891.1| 800|Homo sapiens mixed lineage
kinase-related kinase MRK-alpha protein.
Length = 800
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>AF251441-1|AAF65822.1| 800|Homo sapiens sterile-alpha motif and
leucine zipper containing kinase AZK protein.
Length = 800
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>AF238255-1|AAF63490.1| 800|Homo sapiens mixed lineage kinase ZAK
protein.
Length = 800
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>AB208974-1|BAD92211.1| 845|Homo sapiens Plaucible mixed-lineage
kinase protein variant protein.
Length = 845
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 55 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 112
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 113 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 172
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 173 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 231
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 232 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 291
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 292 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 346
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 347 SFKEQELKERERRLKMWEQKLTEQ 370
>AB049733-1|BAB16444.1| 800|Homo sapiens MLTK-alpha protein.
Length = 800
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>AB030034-1|BAB12040.1| 800|Homo sapiens plaucible mixed-lineage
kinase protein protein.
Length = 800
Score = 213 bits (519), Expect = 1e-54
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>AL133380-4|CAI23046.1| 1036|Homo sapiens mixed lineage kinase 4
(KIAA1804) protein.
Length = 1036
Score = 208 bits (508), Expect = 3e-53
Identities = 133/395 (33%), Positives = 207/395 (52%), Gaps = 47/395 (11%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------L 59
V FE + +G+G G VY +G+ VAVK R+ E D +R+ L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--------------FTPRQII 105
H NI+ RGVC + + C+++EF + G L L + + P ++
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 106 RWAKDIAQGMVYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDN 154
WA IA+GM+YLH I+HRDLKS N+L+ + N K++DFG +REW +
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-H 297
Query: 155 ESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG 214
+ MS GT AWMAPEVI+ S+ D+WS+GV+LWELLT E+PY+ ++ A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 215 TETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVT 273
+ LP+P++CPE L+ +CW + P RP F +IL L I GA + + + F
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 274 QATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRAN 328
Q W+ EI+ E+ T+ KE + ++ LQ +EEL R+ +L E+++ +
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLA-EREI---D 473
Query: 329 ELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
L E+ + QL Q++ + +R+ K R L+
Sbjct: 474 VLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLK 508
>AL133380-3|CAI23045.1| 570|Homo sapiens mixed lineage kinase 4
(KIAA1804) protein.
Length = 570
Score = 208 bits (508), Expect = 3e-53
Identities = 133/395 (33%), Positives = 207/395 (52%), Gaps = 47/395 (11%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------L 59
V FE + +G+G G VY +G+ VAVK R+ E D +R+ L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--------------FTPRQII 105
H NI+ RGVC + + C+++EF + G L L + + P ++
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 106 RWAKDIAQGMVYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDN 154
WA IA+GM+YLH I+HRDLKS N+L+ + N K++DFG +REW +
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-H 297
Query: 155 ESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG 214
+ MS GT AWMAPEVI+ S+ D+WS+GV+LWELLT E+PY+ ++ A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 215 TETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVT 273
+ LP+P++CPE L+ +CW + P RP F +IL L I GA + + + F
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 274 QATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRAN 328
Q W+ EI+ E+ T+ KE + ++ LQ +EEL R+ +L E+++ +
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLA-EREI---D 473
Query: 329 ELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
L E+ + QL Q++ + +R+ K R L+
Sbjct: 474 VLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLK 508
>AJ311798-1|CAC84640.1| 1036|Homo sapiens mixed lineage kinase 4beta
protein.
Length = 1036
Score = 206 bits (503), Expect = 1e-52
Identities = 133/395 (33%), Positives = 206/395 (52%), Gaps = 47/395 (11%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------L 59
V FE + +G+G G VY +G+ VAVK R+ E D +R+ L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--------------FTPRQII 105
H NI+ RGVC + + C+++EF + G L L + + P ++
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 106 RWAKDIAQGMVYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDN 154
WA IA+GM+YLH I+HRDLKS N+L+ + N K++DFG +REW +
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREW-H 297
Query: 155 ESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG 214
+ MS GT AWMAPEVI+ S+ D+WS GV+LWELLT E+PY+ ++ A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 215 TETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVT 273
+ LP+P++CPE L+ +CW + P RP F +IL L I GA + + + F
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 274 QATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRAN 328
Q W+ EI+ E+ T+ KE + ++ LQ +EEL R+ +L E+++ +
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLA-EREI---D 473
Query: 329 ELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
L E+ + QL Q++ + +R+ K R L+
Sbjct: 474 VLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLK 508
>AJ311797-1|CAC84639.1| 570|Homo sapiens mixed lineage kinase
4alpha protein.
Length = 570
Score = 206 bits (503), Expect = 1e-52
Identities = 133/395 (33%), Positives = 206/395 (52%), Gaps = 47/395 (11%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------L 59
V FE + +G+G G VY +G+ VAVK R+ E D +R+ L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--------------FTPRQII 105
H NI+ RGVC + + C+++EF + G L L + + P ++
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 106 RWAKDIAQGMVYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDN 154
WA IA+GM+YLH I+HRDLKS N+L+ + N K++DFG +REW +
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREW-H 297
Query: 155 ESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG 214
+ MS GT AWMAPEVI+ S+ D+WS GV+LWELLT E+PY+ ++ A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 215 TETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVT 273
+ LP+P++CPE L+ +CW + P RP F +IL L I GA + + + F
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 274 QATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRAN 328
Q W+ EI+ E+ T+ KE + ++ LQ +EEL R+ +L E+++ +
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLA-EREI---D 473
Query: 329 ELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
L E+ + QL Q++ + +R+ K R L+
Sbjct: 474 VLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLK 508
>AF465843-1|AAO33376.1| 312|Homo sapiens cervical cancer suppressor
gene-4 protein protein.
Length = 312
Score = 204 bits (499), Expect = 4e-52
Identities = 118/280 (42%), Positives = 167/280 (59%), Gaps = 16/280 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWR 278
+ RP FK I++ L+ + S LPD+ F +A WR
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWR 284
>AC013461-1|AAX93067.1| 400|Homo sapiens unknown protein.
Length = 400
Score = 201 bits (491), Expect = 4e-51
Identities = 115/275 (41%), Positives = 163/275 (59%), Gaps = 14/275 (5%)
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQ 113
L L+H NI++F GV E NY I+ E+ G LYD+++S S I+ WA D+A+
Sbjct: 4 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 63
Query: 114 GMVYLHNR---KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAP 170
GM YLH K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAP
Sbjct: 64 GMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAP 122
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
EVI+ P SE D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S
Sbjct: 123 EVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSF 182
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKE 287
LL+QCW+ + RP FK I++ L+ + S LPD+ F +A WR EIE ++
Sbjct: 183 AELLHQCWEADAKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLER 240
Query: 288 IYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQ 322
+ K + + + K Q ++ E RL + + EQ
Sbjct: 241 L---KKLERDLSFKEQELKERERRLKMWEQKLTEQ 272
>M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein.
Length = 766
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 504
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 623
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 624 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 684 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 724
>M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein.
Length = 328
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 8 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 66
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 67 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 125
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 126 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 185
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 186 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 245
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 246 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 286
>BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 504
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 623
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 624 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 684 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 724
>BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 504
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 623
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 624 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 684 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 724
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 1172 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 1230
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 1231 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 1289
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 1290 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 1349
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 1350 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 1409
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 1410 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 1450
>AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3
protein.
Length = 651
Score = 159 bits (387), Expect = 1e-38
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 331 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 389
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 390 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 448
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 449 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 508
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 509 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 568
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 569 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 609
>X03484-1|CAA27204.1| 648|Homo sapiens protein ( Human mRNA for raf
oncogene. ).
Length = 648
Score = 157 bits (381), Expect = 8e-38
Identities = 97/269 (36%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + +GSG+ G VY G G+ VAVK L+ + T ++ LRK
Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 400
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++ +N I+ ++C+ LY LH F Q+I A+ AQGM YL
Sbjct: 401 RHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
H + IIHRD+KS N+ + + L K+ DFG W V TG+V WMAPEVIR
Sbjct: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVG---TETILLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG L + +CP+
Sbjct: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C +V RP F IL+ +++
Sbjct: 580 AMKRLVADCVKKVKEERPLFPQILSSIEL 608
>L00212-1|AAA60247.1| 421|Homo sapiens RAF1 protein.
Length = 421
Score = 157 bits (381), Expect = 8e-38
Identities = 97/269 (36%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + +GSG+ G VY G G+ VAVK L+ + T ++ LRK
Sbjct: 115 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 173
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++ +N I+ ++C+ LY LH F Q+I A+ AQGM YL
Sbjct: 174 RHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 232
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
H + IIHRD+KS N+ + + L K+ DFG W V TG+V WMAPEVIR
Sbjct: 233 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 292
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVG---TETILLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG L + +CP+
Sbjct: 293 QDNNPFSFQSDVYSYGIVLYELITGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 352
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C +V RP F IL+ +++
Sbjct: 353 AMKRLVADCVKKVKEERPLFPQILSSIEL 381
>BC018119-1|AAH18119.1| 648|Homo sapiens v-raf-1 murine leukemia
viral oncogene homolog 1 protein.
Length = 648
Score = 157 bits (381), Expect = 8e-38
Identities = 97/269 (36%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + +GSG+ G VY G G+ VAVK L+ + T ++ LRK
Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 400
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++ +N I+ ++C+ LY LH F Q+I A+ AQGM YL
Sbjct: 401 RHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
H + IIHRD+KS N+ + + L K+ DFG W V TG+V WMAPEVIR
Sbjct: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVG---TETILLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG L + +CP+
Sbjct: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C +V RP F IL+ +++
Sbjct: 580 AMKRLVADCVKKVKEERPLFPQILSSIEL 608
>AY271661-1|AAP03432.1| 648|Homo sapiens v-raf-1 murine leukemia
viral oncogene homolog 1 protein.
Length = 648
Score = 157 bits (381), Expect = 8e-38
Identities = 97/269 (36%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + +GSG+ G VY G G+ VAVK L+ + T ++ LRK
Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 400
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++ +N I+ ++C+ LY LH F Q+I A+ AQGM YL
Sbjct: 401 RHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
H + IIHRD+KS N+ + + L K+ DFG W V TG+V WMAPEVIR
Sbjct: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVG---TETILLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG L + +CP+
Sbjct: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C +V RP F IL+ +++
Sbjct: 580 AMKRLVADCVKKVKEERPLFPQILSSIEL 608
>M15990-1|AAA35735.1| 543|Homo sapiens protein ( Human c-yes-1
mRNA. ).
Length = 543
Score = 154 bits (374), Expect = 6e-37
Identities = 97/265 (36%), Positives = 140/265 (52%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQG 114
+KL HD +V V SE Y I+ EF G L DFL G + Q++ A IA G
Sbjct: 325 KKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ IHRDL++ N+LV +NLV K++DFG +R DNE +A + W APE
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++ EL+T+ +PY + +L V +P P CPESL
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLH 502
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+N CW + P RP F+ I + L+
Sbjct: 503 ELMNLCWKKDPDERPTFEYIQSFLE 527
>BC048960-1|AAH48960.1| 543|Homo sapiens v-yes-1 Yamaguchi sarcoma
viral oncogene homolog 1 protein.
Length = 543
Score = 154 bits (374), Expect = 6e-37
Identities = 97/265 (36%), Positives = 140/265 (52%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQG 114
+KL HD +V V SE Y I+ EF G L DFL G + Q++ A IA G
Sbjct: 325 KKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ IHRDL++ N+LV +NLV K++DFG +R DNE +A + W APE
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++ EL+T+ +PY + +L V +P P CPESL
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLH 502
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+N CW + P RP F+ I + L+
Sbjct: 503 ELMNLCWKKDPDERPTFEYIQSFLE 527
>M59371-1|AAA53375.1| 976|Homo sapiens protein-tyrosine kinase
protein.
Length = 976
Score = 154 bits (373), Expect = 7e-37
Identities = 96/267 (35%), Positives = 139/267 (52%), Gaps = 21/267 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEM------VAVKKLR----EKEETDIMH---- 55
E+ +T +G+G G VY G L+ VA+K L+ EK+ D +
Sbjct: 607 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI 666
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
+ + +H NI+R GV S+ + II E+ + G L FL F+ Q++ + IA G
Sbjct: 667 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 726
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAP 170
M YL N +HRDL + N+LV NLV KVSDFG SR E D E+ + G + W AP
Sbjct: 727 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 786
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I + + DVWSFG+V+WE++T E PY L H ++ + + LP P CP +
Sbjct: 787 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSA 845
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ L+ QCW + RP F I++ LD
Sbjct: 846 IYQLMMQCWQQERARRPKFADIVSILD 872
>BC037166-1|AAH37166.1| 976|Homo sapiens EPH receptor A2 protein.
Length = 976
Score = 154 bits (373), Expect = 7e-37
Identities = 96/267 (35%), Positives = 139/267 (52%), Gaps = 21/267 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEM------VAVKKLR----EKEETDIMH---- 55
E+ +T +G+G G VY G L+ VA+K L+ EK+ D +
Sbjct: 607 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI 666
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
+ + +H NI+R GV S+ + II E+ + G L FL F+ Q++ + IA G
Sbjct: 667 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 726
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAP 170
M YL N +HRDL + N+LV NLV KVSDFG SR E D E+ + G + W AP
Sbjct: 727 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 786
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I + + DVWSFG+V+WE++T E PY L H ++ + + LP P CP +
Sbjct: 787 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSA 845
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ L+ QCW + RP F I++ LD
Sbjct: 846 IYQLMMQCWQQERARRPKFADIVSILD 872
>AL451042-1|CAH71943.1| 976|Homo sapiens EPH receptor A2 protein.
Length = 976
Score = 154 bits (373), Expect = 7e-37
Identities = 96/267 (35%), Positives = 139/267 (52%), Gaps = 21/267 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEM------VAVKKLR----EKEETDIMH---- 55
E+ +T +G+G G VY G L+ VA+K L+ EK+ D +
Sbjct: 607 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI 666
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
+ + +H NI+R GV S+ + II E+ + G L FL F+ Q++ + IA G
Sbjct: 667 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 726
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAP 170
M YL N +HRDL + N+LV NLV KVSDFG SR E D E+ + G + W AP
Sbjct: 727 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 786
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I + + DVWSFG+V+WE++T E PY L H ++ + + LP P CP +
Sbjct: 787 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSA 845
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ L+ QCW + RP F I++ LD
Sbjct: 846 IYQLMMQCWQQERARRPKFADIVSILD 872
>X02647-1|CAA26485.1| 351|Homo sapiens c-src protein.
Length = 351
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 73 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 132
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 133 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 191
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 192 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 251
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 252 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 310
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 311 DLMCQCWRKEPEERPTFEYLQAFLE 335
>K03218-1|AAA60584.1| 536|Homo sapiens SRC protein.
Length = 536
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 318 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 495
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 496 DLMCQCWRKEPEERPTFEYLQAFLE 520
>DQ314875-1|ABC40734.1| 606|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 606
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>BT019654-1|AAV38460.1| 579|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 579
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>BC051270-1|AAH51270.2| 536|Homo sapiens v-src sarcoma
(Schmidt-Ruppin A-2) viral oncogene homolog (avian)
protein.
Length = 536
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 318 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 495
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 496 DLMCQCWRKEPEERPTFEYLQAFLE 520
>BC017715-1|AAH17715.1| 579|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 579
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>BC011566-1|AAH11566.1| 536|Homo sapiens SRC protein protein.
Length = 536
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 318 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 495
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 496 DLMCQCWRKEPEERPTFEYLQAFLE 520
>AL133293-2|CAC10573.1| 542|Homo sapiens v-src sarcoma
(Schmidt-Ruppin A-2) viral oncogenem exchanger), member
2 protein.
Length = 542
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 264 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 323
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 324 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 382
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 383 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 442
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 443 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 501
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 502 DLMCQCWRKEPEERPTFEYLQAFLE 526
>AL133293-1|CAC34523.1| 536|Homo sapiens v-src sarcoma
(Schmidt-Ruppin A-2) viral oncogenem exchanger), member
2 protein.
Length = 536
Score = 153 bits (371), Expect = 1e-36
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA G
Sbjct: 318 KKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLH 495
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 496 DLMCQCWRKEPEERPTFEYLQAFLE 520
>AL121964-4|CAI19612.1| 606|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 606
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121964-3|CAI19611.1| 579|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 579
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121964-2|CAI19609.1| 491|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 491
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121964-1|CAI19610.1| 518|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 518
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121837-4|CAI23533.1| 579|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 579
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121837-3|CAI23532.1| 606|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 606
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121837-2|CAI23531.1| 491|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 491
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AL121837-1|CAI23530.1| 518|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 518
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AF218074-1|AAF27652.1| 491|Homo sapiens TGF beta-activated kinase
splice variant d protein.
Length = 491
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AB009358-1|BAA25027.2| 518|Homo sapiens TGF-beta activated kinase
1c protein.
Length = 518
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AB009357-1|BAA25026.1| 606|Homo sapiens TGF-beta activated kinase
1b protein.
Length = 606
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>AB009356-1|BAA25025.1| 579|Homo sapiens TGF-beta activated kinase
1a protein.
Length = 579
Score = 153 bits (371), Expect = 1e-36
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>BT019655-1|AAV38461.1| 606|Homo sapiens mitogen-activated protein
kinase kinase kinase 7 protein.
Length = 606
Score = 152 bits (368), Expect = 3e-36
Identities = 86/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
+E+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YNEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>X77278-1|CAA54493.1| 507|Homo sapiens HYL tyrosine kinase protein.
Length = 507
Score = 150 bits (363), Expect = 1e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>S75164-1|AAC60645.1| 507|Homo sapiens megakaryocyte-associated
tyrosine kinase protein.
Length = 507
Score = 150 bits (363), Expect = 1e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>BC003109-1|AAH03109.1| 507|Homo sapiens megakaryocyte-associated
tyrosine kinase protein.
Length = 507
Score = 150 bits (363), Expect = 1e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>BC000114-1|AAH00114.1| 507|Homo sapiens megakaryocyte-associated
tyrosine kinase protein.
Length = 507
Score = 150 bits (363), Expect = 1e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>AC005777-1|AAC62843.1| 507|Homo sapiens MATK_HUMAN protein.
Length = 507
Score = 150 bits (363), Expect = 1e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>U07236-1|AAA18225.1| 512|Homo sapiens lymphocyte-specific protein
tyrosine kinase protein.
Length = 512
Score = 148 bits (359), Expect = 4e-35
Identities = 92/263 (34%), Positives = 143/263 (54%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+G G V+ G G VAVK L++ + L ++
Sbjct: 238 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 297
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GMV
Sbjct: 298 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMV 356
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 357 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 416
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 417 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNLEVIQNL-ERGYRMVRPDNCPEELYQL 475
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 476 MRLCWKERPEDRPTFDYLRSVLE 498
>S65186-1|AAB28072.2| 620|Homo sapiens EMT protein.
Length = 620
Score = 148 bits (359), Expect = 4e-35
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>L10717-1|AAA36748.1| 620|Homo sapiens tyrosine kinase protein.
Length = 620
Score = 148 bits (359), Expect = 4e-35
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>D13720-1|BAA02873.1| 620|Homo sapiens ITK protein.
Length = 620
Score = 148 bits (359), Expect = 4e-35
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>BC109078-1|AAI09079.1| 620|Homo sapiens IL2-inducible T-cell
kinase protein.
Length = 620
Score = 148 bits (359), Expect = 4e-35
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>BC109077-1|AAI09078.1| 620|Homo sapiens IL2-inducible T-cell
kinase protein.
Length = 620
Score = 148 bits (359), Expect = 4e-35
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>Z97989-4|CAI22300.1| 537|Homo sapiens FYN oncogene related to SRC,
FGR, YES protein.
Length = 537
Score = 147 bits (357), Expect = 6e-35
Identities = 93/266 (34%), Positives = 139/266 (52%), Gaps = 18/266 (6%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMH 55
+++ WE+P ES+ + LG+G G V+ G G VA+K L+ EE IM
Sbjct: 260 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM- 318
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQ 113
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 319 -KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPE 171
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W APE
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + + DVWSFG++L EL+T+ +PY + +L V +P P CP SL
Sbjct: 437 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISL 495
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + P RP F+ + + L+
Sbjct: 496 HELMIHCWKKDPEERPTFEYLQSFLE 521
>M14333-1|AAC08285.1| 537|Homo sapiens protein ( Homo sapiens c-syn
protooncogene mRNA, complete cds. ).
Length = 537
Score = 147 bits (357), Expect = 6e-35
Identities = 93/266 (34%), Positives = 139/266 (52%), Gaps = 18/266 (6%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMH 55
+++ WE+P ES+ + LG+G G V+ G G VA+K L+ EE IM
Sbjct: 260 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM- 318
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQ 113
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 319 -KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPE 171
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W APE
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + + DVWSFG++L EL+T+ +PY + +L V +P P CP SL
Sbjct: 437 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISL 495
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + P RP F+ + + L+
Sbjct: 496 HELMIHCWKKDPEERPTFEYLQSFLE 521
>Z84466-8|CAI42468.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog protein.
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>X14055-1|CAA32211.1| 509|Homo sapiens protein ( Human
lymphocyte-specific protein tyrosine kinase (lck) gene,
exon 12. ).
Length = 509
Score = 147 bits (356), Expect = 8e-35
Identities = 91/263 (34%), Positives = 142/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+G G V+ G G VAVK L++ + L ++
Sbjct: 235 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 294
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 295 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 472
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 473 MRLCWKERPEDRPTFDYLRSVLE 495
>X13529-1|CAA31884.1| 509|Homo sapiens protein ( Human lck mRNA for
membrane associated protein tyrosine kinase. ).
Length = 509
Score = 147 bits (356), Expect = 8e-35
Identities = 91/263 (34%), Positives = 142/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+G G V+ G G VAVK L++ + L ++
Sbjct: 235 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 294
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 295 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 472
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 473 MRLCWKERPEDRPTFDYLRSVLE 495
>X04790-1|CAA28476.1| 606|Homo sapiens protein ( Human mRNA for
A-raf-1 oncogene. ).
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>U01337-1|AAB03517.1| 606|Homo sapiens Ser/Thr protein kinase
protein.
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>L36642-1|AAA74243.1| 998|Homo sapiens receptor protein-tyrosine
kinase protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>L24038-1|AAA65219.1| 606|Homo sapiens ARAF1 protein.
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>BT019864-1|AAV38667.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog 1 protein.
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>BC126151-1|AAI26152.1| 998|Homo sapiens EPH receptor A7 protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>BC126125-1|AAI26126.1| 998|Homo sapiens EPH receptor A7 protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>BC007514-1|AAH07514.1| 609|Homo sapiens ARAF protein protein.
Length = 609
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 306 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 364
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 365 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 423
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 424 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 483
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 484 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 543
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 544 AMRRLLSDCLKFQREERPLFPQILATIEL 572
>BC002466-1|AAH02466.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog protein.
Length = 606
Score = 147 bits (356), Expect = 8e-35
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 361
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 362 RHVNILLFMGFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G+V WMA EVIR
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIEL 569
>AL591036-1|CAH73650.1| 998|Homo sapiens EPH receptor A7 protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>AL354857-1|CAH72780.1| 998|Homo sapiens EPH receptor A7 protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>AL121991-2|CAI22320.1| 496|Homo sapiens lymphocyte-specific
protein tyrosine kinase protein.
Length = 496
Score = 147 bits (356), Expect = 8e-35
Identities = 91/263 (34%), Positives = 142/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+G G V+ G G VAVK L++ + L ++
Sbjct: 222 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 281
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 282 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 340
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 341 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 400
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 401 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 459
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 460 MRLCWKERPEDRPTFDYLRSVLE 482
>AL121966-2|CAI19722.1| 998|Homo sapiens EPH receptor A7 protein.
Length = 998
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>AF228313-1|AAF34794.1| 496|Homo sapiens tyrosine kinase LCK
protein.
Length = 496
Score = 147 bits (356), Expect = 8e-35
Identities = 91/263 (34%), Positives = 142/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+G G V+ G G VAVK L++ + L ++
Sbjct: 222 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 281
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 282 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 340
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 341 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 400
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 401 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 459
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 460 MRLCWKERPEDRPTFDYLRSVLE 482
>AB209269-1|BAD92506.1| 1000|Homo sapiens ephrin receptor EphA7
variant protein.
Length = 1000
Score = 147 bits (356), Expect = 8e-35
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 641 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 700
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 701 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 759
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 760 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 819
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 820 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 878
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 879 RAERPKFEQIVGILD 893
>Z25428-1|CAA80915.1| 111|Homo sapiens protein-serine/threonine
kinase protein.
Length = 111
Score = 146 bits (354), Expect = 1e-34
Identities = 65/108 (60%), Positives = 80/108 (74%)
Query: 79 IIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADN 138
+ ME+C +G LY+ L +G TPR ++ W+ IA GM YLH KIIHRDLKSPNVLV
Sbjct: 2 LYMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT 61
Query: 139 LVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+WS
Sbjct: 62 DAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS 109
>X83107-1|CAA58169.1| 675|Homo sapiens bmx protein.
Length = 675
Score = 146 bits (354), Expect = 1e-34
Identities = 87/260 (33%), Positives = 144/260 (55%), Gaps = 14/260 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE----KEE--TDIMHLRKLNH 61
WE+ E IT + LGSG GVV G +G+ VAVK ++E ++E + + KL+H
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHN 120
+V+F GVCS+ I+ E+ G L ++L S G P Q++ D+ +GM +L +
Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 529
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+ IHRDL + N LV +L KVSDFG +R + + +S GT V W APEV +
Sbjct: 530 HQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFK 588
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVW+FG+++WE+ + + PY + ++ V ++ L P+ +++ ++
Sbjct: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 647
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW +P RP F+ +L+ ++
Sbjct: 648 CWHELPEKRPTFQQLLSSIE 667
>M14676-1|AAA36615.1| 537|Homo sapiens protein ( Human src-like
kinase (slk) mRNA, complete cds. ).
Length = 537
Score = 146 bits (354), Expect = 1e-34
Identities = 93/266 (34%), Positives = 139/266 (52%), Gaps = 18/266 (6%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMH 55
+++ WE+P ES+ + LG+G G V+ G G VA+K L+ EE IM
Sbjct: 260 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM- 318
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQ 113
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 319 -KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPE 171
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W APE
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + + DVWSFG++L EL+T+ +PY + +L V +P P CP SL
Sbjct: 437 RALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISL 495
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + P RP F+ + + L+
Sbjct: 496 HELMIHCWKKDPEERPTFEYLQSFLE 521
>BC016652-1|AAH16652.1| 675|Homo sapiens BMX non-receptor tyrosine
kinase protein.
Length = 675
Score = 146 bits (354), Expect = 1e-34
Identities = 87/260 (33%), Positives = 144/260 (55%), Gaps = 14/260 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE----KEE--TDIMHLRKLNH 61
WE+ E IT + LGSG GVV G +G+ VAVK ++E ++E + + KL+H
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHN 120
+V+F GVCS+ I+ E+ G L ++L S G P Q++ D+ +GM +L +
Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 529
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+ IHRDL + N LV +L KVSDFG +R + + +S GT V W APEV +
Sbjct: 530 HQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFK 588
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVW+FG+++WE+ + + PY + ++ V ++ L P+ +++ ++
Sbjct: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 647
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW +P RP F+ +L+ ++
Sbjct: 648 CWHELPEKRPTFQQLLSSIE 667
>AF045459-1|AAC08966.1| 697|Homo sapiens Etk/Bmx cytosolic tyrosine
kinase protein.
Length = 697
Score = 146 bits (354), Expect = 1e-34
Identities = 87/260 (33%), Positives = 144/260 (55%), Gaps = 14/260 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE----KEE--TDIMHLRKLNH 61
WE+ E IT + LGSG GVV G +G+ VAVK ++E ++E + + KL+H
Sbjct: 432 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 491
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHN 120
+V+F GVCS+ I+ E+ G L ++L S G P Q++ D+ +GM +L +
Sbjct: 492 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 551
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+ IHRDL + N LV +L KVSDFG +R + + +S GT V W APEV +
Sbjct: 552 HQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFK 610
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVW+FG+++WE+ + + PY + ++ V ++ L P+ +++ ++
Sbjct: 611 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 669
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW +P RP F+ +L+ ++
Sbjct: 670 CWHELPEKRPTFQQLLSSIE 689
>M83941-1|AAA58633.1| 983|Homo sapiens receptor protein kinase
protein.
Length = 983
Score = 145 bits (352), Expect = 3e-34
Identities = 93/254 (36%), Positives = 139/254 (54%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR----GEM-VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L+ E+ VA+K L+ EK+ D + + + +H NI+R
Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + I+ E+ + G L FL A FT Q++ + IA GM YL + +HRD
Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+L+ NLV KVSDFG SR E D E+A + G + W +PE I + + D
Sbjct: 747 LAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+VLWE+++ E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVLWEVMSYGERPYWEMSNQDVIKAV-DEGYRLPPPMDCPAALYQLMLDCWQKDR 865
Query: 243 RNRPPFKIILAHLD 256
NRP F+ I++ LD
Sbjct: 866 NNRPKFEQIVSILD 879
>BC063282-1|AAH63282.1| 983|Homo sapiens EPH receptor A3 protein.
Length = 983
Score = 145 bits (352), Expect = 3e-34
Identities = 93/254 (36%), Positives = 139/254 (54%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR----GEM-VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L+ E+ VA+K L+ EK+ D + + + +H NI+R
Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + I+ E+ + G L FL A FT Q++ + IA GM YL + +HRD
Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+L+ NLV KVSDFG SR E D E+A + G + W +PE I + + D
Sbjct: 747 LAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+VLWE+++ E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVLWEVMSYGERPYWEMSNQDVIKAV-DEGYRLPPPMDCPAALYQLMLDCWQKDR 865
Query: 243 RNRPPFKIILAHLD 256
NRP F+ I++ LD
Sbjct: 866 NNRPKFEQIVSILD 879
>AF213459-1|AAG43576.1| 983|Homo sapiens ephrin receptor EPHA3
complete form protein.
Length = 983
Score = 145 bits (352), Expect = 3e-34
Identities = 93/254 (36%), Positives = 139/254 (54%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR----GEM-VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L+ E+ VA+K L+ EK+ D + + + +H NI+R
Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + I+ E+ + G L FL A FT Q++ + IA GM YL + +HRD
Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+L+ NLV KVSDFG SR E D E+A + G + W +PE I + + D
Sbjct: 747 LAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+VLWE+++ E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVLWEVMSYGERPYWEMSNQDVIKAV-DEGYRLPPPMDCPAALYQLMLDCWQKDR 865
Query: 243 RNRPPFKIILAHLD 256
NRP F+ I++ LD
Sbjct: 866 NNRPKFEQIVSILD 879
>M36881-1|AAA59502.1| 509|Homo sapiens lymphocyte-specific protein
tyrosine kinase protein.
Length = 509
Score = 144 bits (350), Expect = 4e-34
Identities = 90/263 (34%), Positives = 141/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RK 58
E++WEVP E++ + LG+ G V+ G G VAVK L++ + L ++
Sbjct: 235 EDEWEVPRETLKLVERLGAAQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ 294
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 295 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 472
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 473 MRLCWKERPEDRPTFDYLRSVLE 495
>AL035703-1|CAB81612.1| 1005|Homo sapiens EPH receptor A8 protein.
Length = 1005
Score = 144 bits (350), Expect = 4e-34
Identities = 97/255 (38%), Positives = 132/255 (51%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+GSG G V G LR G+ VA+K L+ E++ D + + + +H NI+R
Sbjct: 641 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE 700
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G I+ E+ + G L FL H G FT Q++ + + GM YL + +HR
Sbjct: 701 GVVTRGRLAMIVTEYMENGSLDTFLRTHDG-QFTIMQLVGMLRGVGAGMRYLSDLGYVHR 759
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + NVLV NLV KVSDFG SR D+ A + TG + W APE I S
Sbjct: 760 DLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS 819
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWSFGVV+WE+L E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 820 DVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLDCWHKD 878
Query: 242 PRNRPPFKIILAHLD 256
RP F I++ LD
Sbjct: 879 RAQRPRFSQIVSVLD 893
>AB040892-1|BAA95983.1| 853|Homo sapiens KIAA1459 protein protein.
Length = 853
Score = 144 bits (350), Expect = 4e-34
Identities = 97/255 (38%), Positives = 132/255 (51%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+GSG G V G LR G+ VA+K L+ E++ D + + + +H NI+R
Sbjct: 489 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE 548
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G I+ E+ + G L FL H G FT Q++ + + GM YL + +HR
Sbjct: 549 GVVTRGRLAMIVTEYMENGSLDTFLRTHDG-QFTIMQLVGMLRGVGAGMRYLSDLGYVHR 607
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + NVLV NLV KVSDFG SR D+ A + TG + W APE I S
Sbjct: 608 DLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS 667
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWSFGVV+WE+L E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 668 DVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLDCWHKD 726
Query: 242 PRNRPPFKIILAHLD 256
RP F I++ LD
Sbjct: 727 RAQRPRFSQIVSVLD 741
>L40636-1|AAB08520.1| 984|Homo sapiens protein tyrosine kinase
protein.
Length = 984
Score = 144 bits (348), Expect = 8e-34
Identities = 92/268 (34%), Positives = 141/268 (52%), Gaps = 24/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
+V F I ++ +G+G G VY G L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 DVSFVKIEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+R GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL +HRDL + N+LV NLV KVSDFG SR ++++ ++T + V W A
Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I + + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPMDCPA 851
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLD 879
>J03358-1|AAA61190.1| 822|Homo sapiens FER protein.
Length = 822
Score = 144 bits (348), Expect = 8e-34
Identities = 91/267 (34%), Positives = 134/267 (50%), Gaps = 18/267 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--EETDIMHL------ 56
++ W + E + LG G G VY G L+ + VAVK +E +E I L
Sbjct: 553 DKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKIL 612
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGM 115
++ +H NIV+ GVC++ + IIME G FL +Q+++++ D A GM
Sbjct: 613 KQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGM 672
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG----TVAWMAPE 171
+YL ++ IHRDL + N LV +N V K+SDFG SR+ D V S +G + W APE
Sbjct: 673 LYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPE 730
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + S DVWSFG++LWE + + PY + V + P CPE +
Sbjct: 731 ALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV-ERGYRMSAPQHCPEDI 789
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLDI 257
++ +CWD P NRP F + L I
Sbjct: 790 SKIMMKCWDYKPENRPKFSELQKELTI 816
>X52192-1|CAA36438.1| 822|Homo sapiens c-fes protein.
Length = 822
Score = 143 bits (346), Expect = 1e-33
Identities = 93/266 (34%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 551 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 610
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 611 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 670
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT----VAWMAP 170
M YL ++ IHRDL + N LV + V K+SDFG SRE + + + G+ V W AP
Sbjct: 671 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGSRQVPVKWTAP 729
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + S DVWSFG++LWE + PY L V + LP P CP++
Sbjct: 730 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPDA 788
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 789 VFRLMEQCWAYEPGQRPSFSTIYQEL 814
>AY513657-1|AAS82869.1| 752|Homo sapiens proto-oncogene c-fes
variant 4 protein.
Length = 752
Score = 143 bits (346), Expect = 1e-33
Identities = 93/266 (34%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT----VAWMAP 170
M YL ++ IHRDL + N LV + V K+SDFG SRE + + + G+ V W AP
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGSRQVPVKWTAP 659
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + S DVWSFG++LWE + PY L V + LP P CP++
Sbjct: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPDA 718
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 719 VFRLMEQCWAYEPGQRPSFSTIYQEL 744
>AY513656-1|AAS82868.1| 764|Homo sapiens proto-oncogene c-fes
variant 3 protein.
Length = 764
Score = 143 bits (346), Expect = 1e-33
Identities = 93/266 (34%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 493 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 552
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 553 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 612
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT----VAWMAP 170
M YL ++ IHRDL + N LV + V K+SDFG SRE + + + G+ V W AP
Sbjct: 613 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGSRQVPVKWTAP 671
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + S DVWSFG++LWE + PY L V + LP P CP++
Sbjct: 672 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPDA 730
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 731 VFRLMEQCWAYEPGQRPSFSTIYQEL 756
>AY513654-1|AAS82866.1| 694|Homo sapiens proto-oncogene c-fes
variant 1 protein.
Length = 694
Score = 143 bits (346), Expect = 1e-33
Identities = 93/266 (34%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 423 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 482
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 483 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 542
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT----VAWMAP 170
M YL ++ IHRDL + N LV + V K+SDFG SRE + + + G+ V W AP
Sbjct: 543 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGSRQVPVKWTAP 601
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + S DVWSFG++LWE + PY L V + LP P CP++
Sbjct: 602 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPDA 660
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 661 VFRLMEQCWAYEPGQRPSFSTIYQEL 686
>X06292-1|CAA29619.1| 822|Homo sapiens NCP92 protein.
Length = 822
Score = 142 bits (345), Expect = 2e-33
Identities = 94/267 (35%), Positives = 132/267 (49%), Gaps = 20/267 (7%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 551 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 610
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 611 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 670
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG-----TVAWMA 169
M YL ++ IHRDL + N LV + V K+SDFG SRE V + +G V W A
Sbjct: 671 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE--EADGVYAASGGLRQVPVKWTA 728
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE + + S DVWSFG++LWE + PY L V + LP P CP+
Sbjct: 729 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPD 787
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHL 255
++ L+ QCW P RP F I L
Sbjct: 788 AVFRLMEQCWAYEPGQRPSFSTIYQEL 814
>M13829-1|AAB08754.1| 298|Homo sapiens raf related protein protein.
Length = 298
Score = 142 bits (345), Expect = 2e-33
Identities = 93/269 (34%), Positives = 142/269 (52%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEVP + + +G+G+ G V+ G G+ VAVK L+ + T ++ LRK
Sbjct: 12 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKT 70
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + II ++C+ LY LH + F Q+I A+ AQGM YL
Sbjct: 71 RHVNILPFMGFMTR-PGVAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 129
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + L K+ DFG W + +G V WMA EV R
Sbjct: 130 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGPVLWMAAEVTRM 189
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+++GVVL+EL+T +PY + I++ VG + L + ++CP+
Sbjct: 190 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 249
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+++ LL+ C RP F ILA +++
Sbjct: 250 AMRRLLSDCLKFQREERPLFPQILATIEL 278
>BC111744-1|AAI11745.1| 984|Homo sapiens EPH receptor B1 protein.
Length = 984
Score = 142 bits (345), Expect = 2e-33
Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 24/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
+V F I ++ +G+G G VY G L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 DVSFVKIEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+R GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL +HRDL + N+L+ NLV KVSDFG SR ++++ ++T + V W A
Sbjct: 733 KYLAEMNYVHRDLAARNILLNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I + + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPMDCPA 851
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLD 879
>BC035357-1|AAH35357.1| 822|Homo sapiens feline sarcoma oncogene
protein.
Length = 822
Score = 142 bits (345), Expect = 2e-33
Identities = 94/267 (35%), Positives = 132/267 (49%), Gaps = 20/267 (7%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 551 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 610
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 611 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 670
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG-----TVAWMA 169
M YL ++ IHRDL + N LV + V K+SDFG SRE V + +G V W A
Sbjct: 671 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE--EADGVYAASGGLRQVPVKWTA 728
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE + + S DVWSFG++LWE + PY L V + LP P CP+
Sbjct: 729 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPD 787
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHL 255
++ L+ QCW P RP F I L
Sbjct: 788 AVFRLMEQCWAYEPGQRPSFSTIYQEL 814
>X05027-1|CAA28691.1| 507|Homo sapiens protein ( Human T
cell-specific mRNA (YT16) for PTK homologous protein PTK
= protein-tyrosine kinase. ).
Length = 507
Score = 142 bits (344), Expect = 2e-33
Identities = 89/263 (33%), Positives = 141/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE------KEETDIMHLRK 58
E++WEVP E++ + LG+G G G G VAVK L++ + + +++
Sbjct: 236 EDEWEVPRETLKLVERLGAGQFGRCGWGTTTGTTKVAVKSLKQGSMSAGRLPAEANLMKQ 295
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L H +VR V ++ Y II E+ + G L DFL SG T +++ A IA+GM
Sbjct: 296 LQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 354
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+D L K++DFG +R DNE +A + W APE I
Sbjct: 355 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 414
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + + DVWSFG++L E++T IPY + ++ + + P++CPE L L
Sbjct: 415 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQL 473
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW P +RP F + + L+
Sbjct: 474 MRLCWKERPEDRPTFDYLRSVLE 496
>AF037332-1|AAD02031.1| 973|Homo sapiens Eph-like receptor tyrosine
kinase hEphB1b protein.
Length = 973
Score = 142 bits (343), Expect = 3e-33
Identities = 91/268 (33%), Positives = 140/268 (52%), Gaps = 24/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
+V F I ++ +G+G G VY G L+ G+ VA+K L+ EK+ D + +
Sbjct: 604 DVSFVKIEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 661
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+R GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 662 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 721
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL +HRDL + N+LV NLV KVSDFG SR ++++ ++T + V W A
Sbjct: 722 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 781
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I + + DVWS+G+ +WE+++ E PY + ++ + + LP P CP
Sbjct: 782 PEAIAYRKFTSASDVWSYGIRMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPTDCPA 840
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 841 ALHQLMLDCWQKDRNSRPRFAEIVNTLD 868
>S71669-1|AAB30995.1| 465|Homo sapiens lsk protein.
Length = 465
Score = 141 bits (342), Expect = 4e-33
Identities = 84/256 (32%), Positives = 135/256 (52%), Gaps = 17/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VK ++ +ET +M
Sbjct: 182 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQK-CVKNIKCDVTAQAFLDETAVM-- 238
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV + Y I+ME G L +FL + A Q+++++ + +G
Sbjct: 239 TKMQHENLVRLLGVILDQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVREG 297
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV++ LVAKVSDFG ++ + S V W APE ++
Sbjct: 298 MEYLESKKLVHRDLAARNILVSEELVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 355
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 356 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKRYRMEP-PEGCPGPVHVL 414
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 415 MSSCWEAEPARRPPFR 430
>M79321-1|AAB50019.1| 491|Homo sapiens Lyn B protein protein.
Length = 491
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 216 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 273
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 274 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 333
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 334 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 393
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 394 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 452
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 453 DIMKMCWKEKAEERPTFDYLQSVLD 477
>M16038-1|AAA59540.1| 512|Homo sapiens LYN protein.
Length = 512
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 294
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 473
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 474 DIMKMCWKEKAEERPTFDYLQSVLD 498
>BC126458-1|AAI26459.1| 512|Homo sapiens LYN protein protein.
Length = 512
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 294
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 473
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 474 DIMKMCWKEKAEERPTFDYLQSVLD 498
>BC126456-1|AAI26457.1| 512|Homo sapiens LYN protein protein.
Length = 512
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 294
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 473
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 474 DIMKMCWKEKAEERPTFDYLQSVLD 498
>BC075002-1|AAH75002.1| 512|Homo sapiens v-yes-1 Yamaguchi sarcoma
viral related oncogene homolog protein.
Length = 512
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 294
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 473
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 474 DIMKMCWKEKAEERPTFDYLQSVLD 498
>BC075001-1|AAH75001.1| 512|Homo sapiens v-yes-1 Yamaguchi sarcoma
viral related oncogene homolog protein.
Length = 512
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 294
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 414
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 473
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 474 DIMKMCWKEKAEERPTFDYLQSVLD 498
>BC068551-1|AAH68551.1| 582|Homo sapiens LYN protein protein.
Length = 582
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 307 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 364
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 365 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 424
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 425 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 484
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 485 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 543
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 544 DIMKMCWKEKAEERPTFDYLQSVLD 568
>BC059394-1|AAH59394.1| 582|Homo sapiens LYN protein protein.
Length = 582
Score = 141 bits (342), Expect = 4e-33
Identities = 92/265 (34%), Positives = 142/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+P ESI + LG+G G V+ G VAVK L+ EE ++M
Sbjct: 307 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLM-- 364
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V + E II E+ G L DFL S G ++I ++ IA+G
Sbjct: 365 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 424
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV+++L+ K++DFG +R DNE +A + W APE
Sbjct: 425 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 484
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + DVWSFG++L+E++T +IPY T+A + ++ +P +CP+ L
Sbjct: 485 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPG-RTNADVMTALSQGYRMPRVENCPDELY 543
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW RP F + + LD
Sbjct: 544 DIMKMCWKEKAEERPTFDYLQSVLD 568
>U22322-1|AAC50116.1| 505|Homo sapiens Rak protein.
Length = 505
Score = 141 bits (341), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase
protein.
Length = 505
Score = 141 bits (341), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>L41939-1|AAA99310.1| 987|Homo sapiens protein-tyrosine kinase
protein.
Length = 987
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 616 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 675
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 676 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 735
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 736 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 795
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 796 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 854
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 882
>L36643-1|AAA74244.1| 970|Homo sapiens receptor protein-tyrosine
kinase protein.
Length = 970
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 599 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 658
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 659 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 718
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 719 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKFPIRWTA 778
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 779 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 837
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 838 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 865
>D29767-1|BAA06171.1| 631|Homo sapiens Tec protein-tyrosine kinase
protein.
Length = 631
Score = 141 bits (341), Expect = 5e-33
Identities = 88/263 (33%), Positives = 134/263 (50%), Gaps = 12/263 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE--ETDIMH----LR 57
S E WE+ +T M LGSG GVV G R + VA+K +RE E D + +
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMV 116
KL H +V+ GVC++ + I+ EF + G L +FL R ++ +D+ +GM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIR 174
YL IHRDL + N LV++ V KVSDFG +R + D ++ V W PEV
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYFLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVWSFGV++WE+ T+ +P++ + ++ V T L P + +
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEV 597
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ +L +D
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTID 620
>BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (341), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>AL512444-4|CAI16429.1| 1055|Homo sapiens EPH receptor B2 protein.
Length = 1055
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL512444-3|CAI16428.1| 987|Homo sapiens EPH receptor B2 protein.
Length = 987
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 616 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 675
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 676 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 735
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 736 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 795
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 796 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 854
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 882
>AL512444-2|CAI16430.2| 986|Homo sapiens EPH receptor B2 protein.
Length = 986
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL512444-1|CAI16427.1| 946|Homo sapiens EPH receptor B2 protein.
Length = 946
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 610 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 669
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 670 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 729
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 730 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 789
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 790 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 848
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 849 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 876
>AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (341), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>AL158086-8|CAI22898.1| 1055|Homo sapiens EPH receptor B2 protein.
Length = 1055
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL158086-7|CAI22899.2| 986|Homo sapiens EPH receptor B2 protein.
Length = 986
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL158086-6|CAI22897.1| 987|Homo sapiens EPH receptor B2 protein.
Length = 987
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 616 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 675
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 676 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 735
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 736 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 795
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 796 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 854
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 882
>AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 141 bits (341), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>AL121829-14|CAC15526.1| 488|Homo sapiens protein ( Human DNA
sequence from clone RP4-697K14 on chromosome 20. ).
Length = 488
Score = 141 bits (341), Expect = 5e-33
Identities = 89/255 (34%), Positives = 131/255 (51%), Gaps = 13/255 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEE--TD----IMHLRK 58
++ WE P LG G G V+ G G + VA+K ++ TD I L+
Sbjct: 220 QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKG 279
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L H+ ++R VCS GE I+ E + G L FL + G + ++ +A +A+GM
Sbjct: 280 LRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMS 339
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL ++++HRDL + NVLV D L KV+DFG +R + D S S V W APE
Sbjct: 340 YLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAAN 399
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S++ DVWSFGV+L E+ T + PY+ + H L + LP P +CP + +L
Sbjct: 400 YRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGYRLPRPAACPAEVYVL 458
Query: 234 LNQCWDRVPRNRPPF 248
+ +CW P RP F
Sbjct: 459 MLECWRSSPEERPSF 473
>AL035704-4|CAI22646.1| 1055|Homo sapiens EPH receptor B2 protein.
Length = 1055
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL035704-3|CAI22645.1| 987|Homo sapiens EPH receptor B2 protein.
Length = 987
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 616 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 675
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 676 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 735
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 736 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 795
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 796 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 854
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 882
>AL035704-2|CAI22647.2| 986|Homo sapiens EPH receptor B2 protein.
Length = 986
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AL035704-1|CAI22644.1| 946|Homo sapiens EPH receptor B2 protein.
Length = 946
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 610 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 669
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 670 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 729
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 730 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 789
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 790 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 848
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 849 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 876
>AF025304-1|AAB94602.1| 1055|Homo sapiens protein-tyrosine kinase
EPHB2v protein.
Length = 1055
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>AB210018-1|BAE06100.1| 1004|Homo sapiens EPHB2 variant protein
protein.
Length = 1004
Score = 141 bits (341), Expect = 5e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 633 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 692
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 693 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 752
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 753 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 812
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 813 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 871
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 872 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 899
>Z97989-6|CAI22299.1| 485|Homo sapiens FYN oncogene related to SRC,
FGR, YES protein.
Length = 485
Score = 140 bits (340), Expect = 7e-33
Identities = 92/267 (34%), Positives = 135/267 (50%), Gaps = 18/267 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIM 54
L+++ WEV S+ LG G V+ G G VA+K L+ EE IM
Sbjct: 207 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 266
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIA 112
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 267 --KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVA 323
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAP 170
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W AP
Sbjct: 324 AGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 383
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + + DVWSFG++L EL+T+ +PY + +L V +P P CP S
Sbjct: 384 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPIS 442
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
L L+ CW + P RP F+ + + L+
Sbjct: 443 LHELMIHCWKKDPEERPTFEYLQSFLE 469
>Z97989-5|CAI22301.1| 534|Homo sapiens FYN oncogene related to SRC,
FGR, YES protein.
Length = 534
Score = 140 bits (340), Expect = 7e-33
Identities = 92/267 (34%), Positives = 135/267 (50%), Gaps = 18/267 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIM 54
L+++ WEV S+ LG G V+ G G VA+K L+ EE IM
Sbjct: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIA 112
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 316 --KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVA 372
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAP 170
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W AP
Sbjct: 373 AGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 432
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + + DVWSFG++L EL+T+ +PY + +L V +P P CP S
Sbjct: 433 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPIS 491
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
L L+ CW + P RP F+ + + L+
Sbjct: 492 LHELMIHCWKKDPEERPTFEYLQSFLE 518
>D37827-1|BAA07073.1| 478|Homo sapiens large erk/cek5 tyrosine
kinase protein.
Length = 478
Score = 140 bits (340), Expect = 7e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 107 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 166
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 167 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 226
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 227 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 286
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 287 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPA 345
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 346 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 373
>D31661-1|BAA06506.1| 981|Homo sapiens tyrosine kinase precursor
protein.
Length = 981
Score = 140 bits (340), Expect = 7e-33
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 610 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 669
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 670 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 729
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 730 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 789
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 790 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPA 848
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 849 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 876
>AF037331-1|AAD02030.1| 984|Homo sapiens Eph-like receptor tyrosine
kinase hEphB1 protein.
Length = 984
Score = 140 bits (340), Expect = 7e-33
Identities = 91/268 (33%), Positives = 139/268 (51%), Gaps = 24/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
+V F I ++ +G+G G VY G L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 DVSFVKIEEV--IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+R GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL +HRDL + N+LV NLV KVSDFG SR ++++ ++T + V W A
Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELL-TQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I + + DVWS+G+ +WE++ E PY + ++ + + LP P CP
Sbjct: 793 PEAIAYRKFTSASDVWSYGIHMWEVMYFGERPYWDMSNQDVINAI-EQDYRLPPPTDCPA 851
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLD 879
>X04434-1|CAA28030.1| 1367|Homo sapiens IGF-I receptor protein.
Length = 1367
Score = 140 bits (338), Expect = 1e-32
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
++WEV E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTP--- 101
+++ N ++VR GV S+G+ +IME G L +L S P
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++I+ A +IA GM YL+ K +HRDL + N +VA++ K+ DFG +R+ ++ +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ L +L V E
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG 1228
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>M32972-1|AAA59452.1| 1382|Homo sapiens insulin receptor protein.
Length = 1382
Score = 140 bits (338), Expect = 1e-32
Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 1074 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1133
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 1134 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1193
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1194 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1252
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P+ RP F +I+ D F V +A
Sbjct: 1253 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 1312
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 1313 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 1344
>M19722-1|AAA52451.1| 529|Homo sapiens FGR protein.
Length = 529
Score = 140 bits (338), Expect = 1e-32
Identities = 93/269 (34%), Positives = 136/269 (50%), Gaps = 18/269 (6%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETD 52
L L+++ WE+ SIT LG+G G V+ G G VAVK L+ EE
Sbjct: 249 LGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQ 308
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKD 110
+M L L HD +V+ V SE Y I+ EF +G L DFL + G Q++ A
Sbjct: 309 VMKL--LRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQ 365
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWM 168
+A+GM Y+ IHRDL++ N+LV + L K++DFG +R + D + + W
Sbjct: 366 VAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWT 425
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCP 227
APE + + DVWSFG++L EL+T+ IPY + +L V + +P P CP
Sbjct: 426 APEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQV-EQGYHMPCPPGCP 484
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
SL + Q W P RP F+ + + L+
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>M10051-1|AAA59174.1| 1382|Homo sapiens INSR protein.
Length = 1382
Score = 140 bits (338), Expect = 1e-32
Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 1074 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1133
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 1134 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1193
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1194 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1252
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P+ RP F +I+ D F V +A
Sbjct: 1253 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 1312
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 1313 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 1344
>BC117172-1|AAI17173.1| 1370|Homo sapiens insulin receptor protein.
Length = 1370
Score = 140 bits (338), Expect = 1e-32
Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 1002 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 1062 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1121
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 1122 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1181
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1240
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P+ RP F +I+ D F V +A
Sbjct: 1241 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 1300
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 1301 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 1332
>BC113612-1|AAI13613.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 140 bits (338), Expect = 1e-32
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
++WEV E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTP--- 101
+++ N ++VR GV S+G+ +IME G L +L S P
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++I+ A +IA GM YL+ K +HRDL + N +VA++ K+ DFG +R+ ++ +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ L +L V E
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG 1228
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>BC113610-1|AAI13611.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 140 bits (338), Expect = 1e-32
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
++WEV E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTP--- 101
+++ N ++VR GV S+G+ +IME G L +L S P
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++I+ A +IA GM YL+ K +HRDL + N +VA++ K+ DFG +R+ ++ +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ L +L V E
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG 1228
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>BC064382-1|AAH64382.1| 529|Homo sapiens Gardner-Rasheed feline
sarcoma viral (v-fgr) oncogene homolog protein.
Length = 529
Score = 140 bits (338), Expect = 1e-32
Identities = 93/269 (34%), Positives = 136/269 (50%), Gaps = 18/269 (6%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETD 52
L L+++ WE+ SIT LG+G G V+ G G VAVK L+ EE
Sbjct: 249 LGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQ 308
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKD 110
+M L L HD +V+ V SE Y I+ EF +G L DFL + G Q++ A
Sbjct: 309 VMKL--LRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQ 365
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWM 168
+A+GM Y+ IHRDL++ N+LV + L K++DFG +R + D + + W
Sbjct: 366 VAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWT 425
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCP 227
APE + + DVWSFG++L EL+T+ IPY + +L V + +P P CP
Sbjct: 426 APEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQV-EQGYHMPCPPGCP 484
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
SL + Q W P RP F+ + + L+
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>AY332722-1|AAP81165.1| 1367|Homo sapiens insulin-like growth factor 1
receptor protein.
Length = 1367
Score = 140 bits (338), Expect = 1e-32
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
++WEV E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTP--- 101
+++ N ++VR GV S+G+ +IME G L +L S P
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++I+ A +IA GM YL+ K +HRDL + N +VA++ K+ DFG +R+ ++ +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ L +L V E
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG 1228
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>AL031729-3|CAB62998.1| 529|Homo sapiens Gardner-Rasheed feline
sarcoma viral (v-fgr) oncogene homolog protein.
Length = 529
Score = 140 bits (338), Expect = 1e-32
Identities = 93/269 (34%), Positives = 136/269 (50%), Gaps = 18/269 (6%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETD 52
L L+++ WE+ SIT LG+G G V+ G G VAVK L+ EE
Sbjct: 249 LGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQ 308
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKD 110
+M L L HD +V+ V SE Y I+ EF +G L DFL + G Q++ A
Sbjct: 309 VMKL--LRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQ 365
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWM 168
+A+GM Y+ IHRDL++ N+LV + L K++DFG +R + D + + W
Sbjct: 366 VAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWT 425
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCP 227
APE + + DVWSFG++L EL+T+ IPY + +L V + +P P CP
Sbjct: 426 APEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQV-EQGYHMPCPPGCP 484
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
SL + Q W P RP F+ + + L+
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>AB208861-1|BAD92098.1| 833|Homo sapiens insulin receptor variant
protein.
Length = 833
Score = 140 bits (338), Expect = 1e-32
Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 465 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 524
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 525 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 584
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 585 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 644
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 645 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 703
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P+ RP F +I+ D F V +A
Sbjct: 704 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 763
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 764 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 795
>X58741-1|CAA41565.2| 348|Homo sapiens tyrosine kinase protein.
Length = 348
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 74 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 133
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 134 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 192
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 193 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 252
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 253 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 311
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 312 MMRCWKNRPEERPTFEYIQSVLD 334
>S74774-1|AAB33113.2| 534|Homo sapiens tyrosine kinase p59fyn(T)
protein.
Length = 534
Score = 139 bits (337), Expect = 2e-32
Identities = 92/267 (34%), Positives = 135/267 (50%), Gaps = 18/267 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIM 54
L+++ WEV S+ LG G V+ G G VA+K L+ EE IM
Sbjct: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIA 112
+KL HD +V+ V SE Y I+ E+ G L DFL G + ++ A +A
Sbjct: 316 --KKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVA 372
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAP 170
GM Y+ IHRDL+S N+LV + L+ K++DFG +R DNE +A + W AP
Sbjct: 373 AGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 432
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + + DVWSFG++L EL+T+ +PY + +L V +P P CP S
Sbjct: 433 ERALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPIS 491
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
L L+ CW + P RP F+ + + L+
Sbjct: 492 LHELMIHCWKKDPEERPTFEYLQSFLE 518
>M16592-1|AAA52644.1| 505|Homo sapiens HCK protein.
Length = 505
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 231 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 290
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 291 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 349
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 350 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 409
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 410 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 468
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 469 MMRCWKNRPEERPTFEYIQSVLD 491
>M16591-1|AAA52643.1| 505|Homo sapiens HCK protein.
Length = 505
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 231 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 290
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 291 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 349
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 350 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 409
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 410 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 468
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 469 MMRCWKNRPEERPTFEYIQSVLD 491
>BC114463-1|AAI14464.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>BC108931-1|AAI08932.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>BC108930-1|AAI08931.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>BC101713-1|AAI01714.1| 631|Homo sapiens tec protein tyrosine
kinase protein.
Length = 631
Score = 139 bits (337), Expect = 2e-32
Identities = 88/263 (33%), Positives = 133/263 (50%), Gaps = 12/263 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE--ETDIMH----LR 57
S E WE+ +T M LGSG GVV G R + VA+K +RE E D + +
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMV 116
KL H +V+ GVC++ + I+ EF + G L +FL R ++ +D+ +GM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIR 174
YL IHRDL + N LV++ V KVSDFG +R D ++ V W PEV
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVWSFGV++WE+ T+ +P++ + ++ V T L P + +
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEV 597
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ +L +D
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTID 620
>BC101711-1|AAI01712.1| 631|Homo sapiens tec protein tyrosine
kinase protein.
Length = 631
Score = 139 bits (337), Expect = 2e-32
Identities = 88/263 (33%), Positives = 133/263 (50%), Gaps = 12/263 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE--ETDIMH----LR 57
S E WE+ +T M LGSG GVV G R + VA+K +RE E D + +
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMV 116
KL H +V+ GVC++ + I+ EF + G L +FL R ++ +D+ +GM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIR 174
YL IHRDL + N LV++ V KVSDFG +R D ++ V W PEV
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVWSFGV++WE+ T+ +P++ + ++ V T L P + +
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEV 597
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ +L +D
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTID 620
>BC094847-1|AAH94847.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>BC014435-1|AAH14435.2| 526|Homo sapiens hemopoietic cell kinase
protein.
Length = 526
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>AL353092-2|CAI19694.1| 505|Homo sapiens hemopoietic cell kinase
protein.
Length = 505
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 231 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 290
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 291 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 349
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 350 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 409
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 410 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 468
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 469 MMRCWKNRPEERPTFEYIQSVLD 491
>AL353092-1|CAI19695.1| 504|Homo sapiens hemopoietic cell kinase
protein.
Length = 504
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 230 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 289
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 290 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 348
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 349 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 409 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 467
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 468 MMRCWKNRPEERPTFEYIQSVLD 490
>AL049539-2|CAI22967.1| 504|Homo sapiens hemopoietic cell kinase
protein.
Length = 504
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 230 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 289
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 290 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 348
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 349 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 409 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 467
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 468 MMRCWKNRPEERPTFEYIQSVLD 490
>AL049539-1|CAI22966.1| 505|Homo sapiens hemopoietic cell kinase
protein.
Length = 505
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 231 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 290
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 291 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 349
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 350 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 409
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 410 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 468
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 469 MMRCWKNRPEERPTFEYIQSVLD 491
>AK026432-1|BAB15482.1| 505|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22779 fis, clone KAIA1741. ).
Length = 505
Score = 139 bits (337), Expect = 2e-32
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 231 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 290
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 291 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 349
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 350 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 409
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 410 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 468
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 469 MMRCWKNRPEERPTFEYIQSVLD 491
>X02160-1|CAA26096.1| 1370|Homo sapiens protein ( Human mRNA for
insulin receptor precursor. ).
Length = 1370
Score = 139 bits (336), Expect = 2e-32
Identities = 103/332 (31%), Positives = 167/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 1002 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 1062 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1121
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 1122 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1181
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1240
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P RP F +I+ D F V +A
Sbjct: 1241 GYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 1300
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 1301 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 1332
>X95425-1|CAA64700.1| 1037|Homo sapiens EHK-1 receptor tyrosine
kinase protein.
Length = 1037
Score = 138 bits (335), Expect = 3e-32
Identities = 92/266 (34%), Positives = 138/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 728
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + I+ GM
Sbjct: 729 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 788
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDFG SR E D E+A + G + W APE
Sbjct: 789 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 848
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 849 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 907
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 908 YQLMLDCWQKERNSRPKFDEIVNMLD 933
>L36644-1|AAA74245.1| 991|Homo sapiens receptor protein-tyrosine
kinase protein.
Length = 991
Score = 138 bits (335), Expect = 3e-32
Identities = 92/266 (34%), Positives = 138/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 623 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 682
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + I+ GM
Sbjct: 683 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 742
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDFG SR E D E+A + G + W APE
Sbjct: 743 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 802
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 803 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 861
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 862 YQLMLDCWQKERNSRPKFDEIVNMLD 887
>AB209375-1|BAD92612.1| 1017|Homo sapiens ephrin receptor EphA5
isoform a variant protein.
Length = 1017
Score = 138 bits (335), Expect = 3e-32
Identities = 92/266 (34%), Positives = 138/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 683 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 742
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + I+ GM
Sbjct: 743 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 802
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDFG SR E D E+A + G + W APE
Sbjct: 803 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 862
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 863 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 921
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 922 YQLMLDCWQKERNSRPKFDEIVNMLD 947
>Z33998-1|CAA83965.1| 505|Homo sapiens Protein-Tyrosine Kinase
protein.
Length = 505
Score = 138 bits (333), Expect = 5e-32
Identities = 83/264 (31%), Positives = 145/264 (54%), Gaps = 14/264 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEET------DIMHLR 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + + ++
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANMMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE I
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW P RP F+ + + L+
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLE 491
>L27071-1|AAA74557.1| 527|Homo sapiens tyrosine kinase protein.
Length = 527
Score = 138 bits (333), Expect = 5e-32
Identities = 82/259 (31%), Positives = 131/259 (50%), Gaps = 12/259 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMH----LR 57
S E WE+ + + +GSG GVV+ G R + VA+K + E E D + +
Sbjct: 260 SYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMM 319
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMV 116
KL+H +V+ GVC + + I+ EF + G L ++L ++ +DI +GM
Sbjct: 320 KLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGME 379
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPEVIR 174
YL IHRDL + N LV+ + K+SDFG +R ++ V SF + W PEV
Sbjct: 380 YLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFL 439
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFGV++WE+ T+ ++P++ ++ + +E L P+ P S+ +
Sbjct: 440 FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI-SEGFRLYRPHLAPMSIYEV 498
Query: 234 LNQCWDRVPRNRPPFKIIL 252
+ CW P RP F +L
Sbjct: 499 MYSCWHEKPEGRPTFAELL 517
>BC113854-1|AAI13855.2| 504|Homo sapiens HCK protein protein.
Length = 504
Score = 137 bits (332), Expect = 7e-32
Identities = 88/263 (33%), Positives = 139/263 (52%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 230 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 289
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 290 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 348
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R HRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 349 FIEQRNYTHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 409 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 467
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 468 MMRCWKNRPEERPTFEYIQSVLD 490
>BC032413-1|AAH32413.1| 505|Homo sapiens B lymphoid tyrosine kinase
protein.
Length = 505
Score = 137 bits (332), Expect = 7e-32
Identities = 84/264 (31%), Positives = 144/264 (54%), Gaps = 14/264 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------R 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + L +
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE I
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW P RP F+ + + L+
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLE 491
>BC007371-1|AAH07371.1| 505|Homo sapiens B lymphoid tyrosine kinase
protein.
Length = 505
Score = 137 bits (332), Expect = 7e-32
Identities = 84/264 (31%), Positives = 144/264 (54%), Gaps = 14/264 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------R 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + L +
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE I
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW P RP F+ + + L+
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLE 491
>X58957-1|CAA41728.1| 659|Homo sapiens agammaglobulinaemia tyrosine
kinase protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>U78027-4|AAB64205.1| 659|Homo sapiens Bruton's tyrosine kinase
protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>U13433-1|AAC51347.1| 657|Homo sapiens Bruton's agammaglobulinemia
tyrosine kinase protein.
Length = 657
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 393 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 452
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 453 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 512
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 513 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 572
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 573 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 631
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 632 WHEKADERPTFKILLSNILDVMDEE 656
>U10087-1|AAB60639.1| 659|Homo sapiens Bruton agammaglobulinemia
tyrosine kinase protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>L31572-1|AAA61479.1| 659|Homo sapiens Bruton agammaglobulinemia
protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>BC109080-1|AAI09081.1| 659|Homo sapiens Bruton agammaglobulinemia
tyrosine kinase protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>BC109079-1|AAI09080.1| 659|Homo sapiens Bruton agammaglobulinemia
tyrosine kinase protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>AL035422-3|CAB55876.1| 659|Homo sapiens Bruton agammaglobulinemia
tyrosine kinase protein.
Length = 659
Score = 137 bits (331), Expect = 9e-32
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>D14717-1|BAA03537.1| 347|Homo sapiens large erk kinase protein.
Length = 347
Score = 136 bits (328), Expect = 2e-31
Identities = 79/233 (33%), Positives = 124/233 (53%), Gaps = 17/233 (7%)
Query: 40 VAVKKLR----EKEETDIMHLRKL----NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYD 91
VA+K L+ EK+ D + R + +H N++ GV ++ II EF + G L
Sbjct: 11 VAIKTLKSGYTEKQRRDFLSERSIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 70
Query: 92 FLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR 150
FL FT Q++ + IA GM YL + +HRDL + N+LV NLV KVSDFG SR
Sbjct: 71 FLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR 130
Query: 151 EWDNESAVMSFTGT------VAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKT 203
+++++ ++T + W APE I++ + DVWS+G+V+WE+++ E PY
Sbjct: 131 FLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWD 190
Query: 204 LETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ ++ + + LP P CP +L L+ CW + +RP F I+ LD
Sbjct: 191 MTNQDVINAI-EQDYRLPPPMDCPAALHQLMLDCWQKDRNHRPKFGQIVNTLD 242
>U34379-1|AAB60412.1| 527|Homo sapiens tyrosine kinase protein.
Length = 527
Score = 135 bits (327), Expect = 3e-31
Identities = 81/259 (31%), Positives = 130/259 (50%), Gaps = 12/259 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMH----LR 57
S E WE+ + + +GSG GVV+ G R + VA+K + E E D + +
Sbjct: 260 SYEKWEIDPSELAFIKXIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMM 319
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMV 116
KL+H +V+ GVC + + I+ EF + G L ++L ++ + I +GM
Sbjct: 320 KLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQXICEGME 379
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPEVIR 174
YL IHRDL + N LV+ + K+SDFG +R ++ V SF + W PEV
Sbjct: 380 YLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFL 439
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFGV++WE+ T+ ++P++ ++ + +E L P+ P S+ +
Sbjct: 440 FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI-SEGFRLYRPHLAPMSIYEV 498
Query: 234 LNQCWDRVPRNRPPFKIIL 252
+ CW P RP F +L
Sbjct: 499 MYSCWHEKPEGRPTFAELL 517
>S76617-1|AAB33265.1| 505|Homo sapiens blk protein.
Length = 505
Score = 135 bits (327), Expect = 3e-31
Identities = 83/264 (31%), Positives = 143/264 (54%), Gaps = 14/264 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------R 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + L +
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAYH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW P RP F+ + + L+
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLE 491
>L18974-1|AAA16703.1| 527|Homo sapiens tyrosine kinase protein.
Length = 527
Score = 135 bits (327), Expect = 3e-31
Identities = 83/249 (33%), Positives = 133/249 (53%), Gaps = 17/249 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 H-GFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 455
Query: 234 LNQCWDRVP 242
++ CW+ P
Sbjct: 456 MSSCWEAEP 464
>BX537946-1|CAD97914.1| 969|Homo sapiens hypothetical protein
protein.
Length = 969
Score = 135 bits (327), Expect = 3e-31
Identities = 91/266 (34%), Positives = 137/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 601 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 660
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + I+ GM
Sbjct: 661 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 720
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDF SR E D E+A + G + W APE
Sbjct: 721 KYLSDMGYVHRDLAARNILINSNLVCKVSDFELSRVLEDDPEAAYTTRGGKIPIRWTAPE 780
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 781 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 839
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 840 YQLMLDCWQKERNSRPKFDEIVNMLD 865
>BC018703-1|AAH18703.1| 599|Homo sapiens Unknown (protein for
IMAGE:4574968) protein.
Length = 599
Score = 135 bits (327), Expect = 3e-31
Identities = 83/256 (32%), Positives = 139/256 (54%), Gaps = 14/256 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------R 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + L +
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE I
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPF 248
++ +CW P RP F
Sbjct: 468 VIAECWRSRPEERPTF 483
>X78549-1|CAA55295.1| 451|Homo sapiens tyrosine kinase protein.
Length = 451
Score = 135 bits (326), Expect = 4e-31
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 15/262 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKL-------REKEETDIMHLRK 58
+DWE P E T LGSG G V+ G + + VA+K + ++ +++I ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTP-RQIIRWAKDIAQGMV 116
L H +I+ V S G+ II E G L + L S P +++ A +A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL ++ IHRDL + N+LV +N + KV DFG +R E +S + W APE +
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFG++L E+ ++ ++PY + H V +P P CP S+ L
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDA-GYRMPCPLECPPSVHKL 419
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW R P RP FK + L
Sbjct: 420 MLTCWCRDPEQRPCFKALRERL 441
>U61412-1|AAC34935.1| 451|Homo sapiens non-receptor type protein
tyrosine kinase protein.
Length = 451
Score = 135 bits (326), Expect = 4e-31
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 15/262 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKL-------REKEETDIMHLRK 58
+DWE P E T LGSG G V+ G + + VA+K + ++ +++I ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTP-RQIIRWAKDIAQGMV 116
L H +I+ V S G+ II E G L + L S P +++ A +A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL ++ IHRDL + N+LV +N + KV DFG +R E +S + W APE +
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFG++L E+ ++ ++PY + H V +P P CP S+ L
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDA-GYRMPCPLECPPSVHKL 419
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW R P RP FK + L
Sbjct: 420 MLTCWCRDPEQRPCFKALRERL 441
>BC035843-1|AAH35843.1| 451|Homo sapiens PTK6 protein tyrosine
kinase 6 protein.
Length = 451
Score = 135 bits (326), Expect = 4e-31
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 15/262 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKL-------REKEETDIMHLRK 58
+DWE P E T LGSG G V+ G + + VA+K + ++ +++I ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTP-RQIIRWAKDIAQGMV 116
L H +I+ V S G+ II E G L + L S P +++ A +A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL ++ IHRDL + N+LV +N + KV DFG +R E +S + W APE +
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFG++L E+ ++ ++PY + H V +P P CP S+ L
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDA-GYRMPCPLECPPSVHKL 419
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW R P RP FK + L
Sbjct: 420 MLTCWCRDPEQRPCFKALRERL 441
>AL121829-13|CAC15525.1| 451|Homo sapiens Ptk6 protein.
Length = 451
Score = 135 bits (326), Expect = 4e-31
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 15/262 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKL-------REKEETDIMHLRK 58
+DWE P E T LGSG G V+ G + + VA+K + ++ +++I ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTP-RQIIRWAKDIAQGMV 116
L H +I+ V S G+ II E G L + L S P +++ A +A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL ++ IHRDL + N+LV +N + KV DFG +R E +S + W APE +
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFG++L E+ ++ ++PY + H V +P P CP S+ L
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDA-GYRMPCPLECPPSVHKL 419
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW R P RP FK + L
Sbjct: 420 MLTCWCRDPEQRPCFKALRERL 441
>L36645-1|AAA74246.1| 986|Homo sapiens receptor protein-tyrosine
kinase protein.
Length = 986
Score = 134 bits (325), Expect = 5e-31
Identities = 89/254 (35%), Positives = 133/254 (52%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G G G V SG L+ G+ VA+K L+ +K+ D + + + +H NI+
Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II E+ + G L FL FT Q++ + I GM YL + +HRD
Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+LV NLV KVSDFG SR E D E+A + G + W APE I + + D
Sbjct: 747 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+V+WE+++ E PY + ++ + E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKER 865
Query: 243 RNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 866 SDRPKFGQIVNMLD 879
>BC105002-1|AAI05003.1| 986|Homo sapiens ephrin receptor EphA4
protein.
Length = 986
Score = 134 bits (325), Expect = 5e-31
Identities = 89/254 (35%), Positives = 133/254 (52%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G G G V SG L+ G+ VA+K L+ +K+ D + + + +H NI+
Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II E+ + G L FL FT Q++ + I GM YL + +HRD
Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+LV NLV KVSDFG SR E D E+A + G + W APE I + + D
Sbjct: 747 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+V+WE+++ E PY + ++ + E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKER 865
Query: 243 RNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 866 SDRPKFGQIVNMLD 879
>BC105000-1|AAI05001.1| 986|Homo sapiens EPH receptor A4 protein.
Length = 986
Score = 134 bits (325), Expect = 5e-31
Identities = 89/254 (35%), Positives = 133/254 (52%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G G G V SG L+ G+ VA+K L+ +K+ D + + + +H NI+
Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II E+ + G L FL FT Q++ + I GM YL + +HRD
Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+LV NLV KVSDFG SR E D E+A + G + W APE I + + D
Sbjct: 747 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+V+WE+++ E PY + ++ + E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKER 865
Query: 243 RNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 866 SDRPKFGQIVNMLD 879
>BC026327-1|AAH26327.1| 949|Homo sapiens EPHA4 protein protein.
Length = 949
Score = 134 bits (325), Expect = 5e-31
Identities = 89/254 (35%), Positives = 133/254 (52%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G G G V SG L+ G+ VA+K L+ +K+ D + + + +H NI+
Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II E+ + G L FL FT Q++ + I GM YL + +HRD
Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 746
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+LV NLV KVSDFG SR E D E+A + G + W APE I + + D
Sbjct: 747 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 806
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+V+WE+++ E PY + ++ + E LP P CP +L L+ CW +
Sbjct: 807 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKER 865
Query: 243 RNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 866 SDRPKFGQIVNMLD 879
>AK024281-1|BAB14871.1| 251|Homo sapiens protein ( Homo sapiens
cDNA FLJ14219 fis, clone NT2RP3003800, highly similar to
Rattus norvegicus tyrosine protein kinase pp60-c-src
mRNA. ).
Length = 251
Score = 134 bits (325), Expect = 5e-31
Identities = 78/206 (37%), Positives = 113/206 (54%), Gaps = 7/206 (3%)
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQ 113
++KL H+ +V+ V SE Y I+ E+ G L DFL +G Q++ A IA
Sbjct: 32 MKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 90
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPE 171
GM Y+ +HRDL++ N+LV +NLV KV+DFG +R DNE +A + W APE
Sbjct: 91 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 150
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + + DVWSFG++L EL T+ +PY + +L V +P P CPESL
Sbjct: 151 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESL 209
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW + P RP F+ + A L+
Sbjct: 210 HDLMCQCWRKEPEERPTFEYLQAFLE 235
>AC010899-2|AAY24284.1| 711|Homo sapiens unknown protein.
Length = 711
Score = 134 bits (325), Expect = 5e-31
Identities = 89/254 (35%), Positives = 133/254 (52%), Gaps = 20/254 (7%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G G G V SG L+ G+ VA+K L+ +K+ D + + + +H NI+
Sbjct: 352 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 411
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II E+ + G L FL FT Q++ + I GM YL + +HRD
Sbjct: 412 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 471
Query: 128 LKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERVD 183
L + N+LV NLV KVSDFG SR E D E+A + G + W APE I + + D
Sbjct: 472 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 531
Query: 184 VWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
VWS+G+V+WE+++ E PY + ++ + E LP P CP +L L+ CW +
Sbjct: 532 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMDCPIALHQLMLDCWQKER 590
Query: 243 RNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 591 SDRPKFGQIVNMLD 604
>X75208-1|CAA53021.1| 998|Homo sapiens protein tyrosine
kinase-receptor protein.
Length = 998
Score = 134 bits (323), Expect = 8e-31
Identities = 86/256 (33%), Positives = 131/256 (51%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L R VA+K L+ E++ D + + + +H NI+R
Sbjct: 639 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ I+ EF + L FL + FT Q++ + IA GM YL +HRD
Sbjct: 699 GVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRD 758
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR +++ + ++T + + W APE I + +
Sbjct: 759 LAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSA 818
Query: 182 VDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
DVWS+G+V+WE+++ E PY + ++ V + LP P CP +L L+ CW R
Sbjct: 819 SDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV-EQDYRLPPPMDCPTALHQLMLDCWVR 877
Query: 241 VPRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 878 DRNLRPKFSQIVNTLD 893
>BC052968-1|AAH52968.1| 998|Homo sapiens EPH receptor B3 protein.
Length = 998
Score = 134 bits (323), Expect = 8e-31
Identities = 86/256 (33%), Positives = 131/256 (51%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L R VA+K L+ E++ D + + + +H NI+R
Sbjct: 639 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ I+ EF + L FL + FT Q++ + IA GM YL +HRD
Sbjct: 699 GVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRD 758
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR +++ + ++T + + W APE I + +
Sbjct: 759 LAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSA 818
Query: 182 VDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
DVWS+G+V+WE+++ E PY + ++ V + LP P CP +L L+ CW R
Sbjct: 819 SDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV-EQDYRLPPPMDCPTALHQLMLDCWVR 877
Query: 241 VPRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 878 DRNLRPKFSQIVNTLD 893
>Z98880-3|CAI42375.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 133 bits (322), Expect = 1e-30
Identities = 125/408 (30%), Positives = 183/408 (44%), Gaps = 43/408 (10%)
Query: 12 PFESITDMMYLGSGAQGVVYSGNL-------RGEM-VAVKKLR----EKEETDIM---HL 56
P E +T + LGSGA G VY G GE+ VAVK L+ ++E+ + + HL
Sbjct: 1935 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 1994
Query: 57 R-KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTPRQIIRWA 108
K NH NI++ GVC E II+E + G L +L G T ++
Sbjct: 1995 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 2054
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSRE-WDNESAVMSFT 162
DI++G VYL IHRDL + N LV+ + K+ DFG +R+ + N+
Sbjct: 2055 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 2114
Query: 163 GT--VAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETIL 219
G V WMAPE + + + DVWSFG+++WE+LT PY +L V T L
Sbjct: 2115 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 2174
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEF-SRVLPDRFSVTQA-TW 277
P P +CP+ L L+ QCW + P RP F I L + F + + R +
Sbjct: 2175 EP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI 2233
Query: 278 RKEIENEMKEIYTRNKEKFEQAQKLQSVRREELR---LARDTRLIYEQQLSRANELYMEV 334
+ E E ++ N + +++ RE L LA + E+ E
Sbjct: 2234 NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESES 2293
Query: 335 CAVRLQLEQKEKHLDE---REKALKLCRCGLRKTLKYYQRQNSSSSDG 379
C +R E+KE H D+ +EK + C G + L Y +S DG
Sbjct: 2294 CGLR--KEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDG 2339
>Z98880-2|CAI42374.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 133 bits (322), Expect = 1e-30
Identities = 125/408 (30%), Positives = 183/408 (44%), Gaps = 43/408 (10%)
Query: 12 PFESITDMMYLGSGAQGVVYSGNL-------RGEM-VAVKKLR----EKEETDIM---HL 56
P E +T + LGSGA G VY G GE+ VAVK L+ ++E+ + + HL
Sbjct: 1941 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 2000
Query: 57 R-KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTPRQIIRWA 108
K NH NI++ GVC E II+E + G L +L G T ++
Sbjct: 2001 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 2060
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSRE-WDNESAVMSFT 162
DI++G VYL IHRDL + N LV+ + K+ DFG +R+ + N+
Sbjct: 2061 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 2120
Query: 163 GT--VAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETIL 219
G V WMAPE + + + DVWSFG+++WE+LT PY +L V T L
Sbjct: 2121 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 2180
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEF-SRVLPDRFSVTQA-TW 277
P P +CP+ L L+ QCW + P RP F I L + F + + R +
Sbjct: 2181 EP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI 2239
Query: 278 RKEIENEMKEIYTRNKEKFEQAQKLQSVRREELR---LARDTRLIYEQQLSRANELYMEV 334
+ E E ++ N + +++ RE L LA + E+ E
Sbjct: 2240 NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESES 2299
Query: 335 CAVRLQLEQKEKHLDE---REKALKLCRCGLRKTLKYYQRQNSSSSDG 379
C +R E+KE H D+ +EK + C G + L Y +S DG
Sbjct: 2300 CGLR--KEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDG 2345
>M13880-1|AAA36580.1| 494|Homo sapiens protein ( Human mcf3
(rearranged ros1) proto-oncogene mRNA encoding a
transmembrane protein kinase, 3' end. ).
Length = 494
Score = 133 bits (322), Expect = 1e-30
Identities = 125/408 (30%), Positives = 183/408 (44%), Gaps = 43/408 (10%)
Query: 12 PFESITDMMYLGSGAQGVVYSGNL-------RGEM-VAVKKLR----EKEETDIM---HL 56
P E +T + LGSGA G VY G GE+ VAVK L+ ++E+ + + HL
Sbjct: 88 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 147
Query: 57 R-KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTPRQIIRWA 108
K NH NI++ GVC E II+E + G L +L G T ++
Sbjct: 148 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 207
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSRE-WDNESAVMSFT 162
DI++G VYL IHRDL + N LV+ + K+ DFG +R+ + N+
Sbjct: 208 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 267
Query: 163 GT--VAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETIL 219
G V WMAPE + + + DVWSFG+++WE+LT PY +L V T L
Sbjct: 268 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 327
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEF-SRVLPDRFSVTQA-TW 277
P P +CP+ L L+ QCW + P RP F I L + F + + R +
Sbjct: 328 EP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI 386
Query: 278 RKEIENEMKEIYTRNKEKFEQAQKLQSVRREELR---LARDTRLIYEQQLSRANELYMEV 334
+ E E ++ N + +++ RE L LA + E+ E
Sbjct: 387 NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESES 446
Query: 335 CAVRLQLEQKEKHLDE---REKALKLCRCGLRKTLKYYQRQNSSSSDG 379
C +R E+KE H D+ +EK + C G + L Y +S DG
Sbjct: 447 CGLR--KEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDG 492
>AL132671-5|CAI23378.1| 2347|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2347
Score = 133 bits (322), Expect = 1e-30
Identities = 125/408 (30%), Positives = 183/408 (44%), Gaps = 43/408 (10%)
Query: 12 PFESITDMMYLGSGAQGVVYSGNL-------RGEM-VAVKKLR----EKEETDIM---HL 56
P E +T + LGSGA G VY G GE+ VAVK L+ ++E+ + + HL
Sbjct: 1941 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 2000
Query: 57 R-KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTPRQIIRWA 108
K NH NI++ GVC E II+E + G L +L G T ++
Sbjct: 2001 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 2060
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSRE-WDNESAVMSFT 162
DI++G VYL IHRDL + N LV+ + K+ DFG +R+ + N+
Sbjct: 2061 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 2120
Query: 163 GT--VAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETIL 219
G V WMAPE + + + DVWSFG+++WE+LT PY +L V T L
Sbjct: 2121 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 2180
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEF-SRVLPDRFSVTQA-TW 277
P P +CP+ L L+ QCW + P RP F I L + F + + R +
Sbjct: 2181 EP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI 2239
Query: 278 RKEIENEMKEIYTRNKEKFEQAQKLQSVRREELR---LARDTRLIYEQQLSRANELYMEV 334
+ E E ++ N + +++ RE L LA + E+ E
Sbjct: 2240 NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESES 2299
Query: 335 CAVRLQLEQKEKHLDE---REKALKLCRCGLRKTLKYYQRQNSSSSDG 379
C +R E+KE H D+ +EK + C G + L Y +S DG
Sbjct: 2300 CGLR--KEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDG 2345
>AL132671-4|CAI23379.1| 2341|Homo sapiens v-ros UR2 sarcoma virus
oncogene homolog 1 (avian) protein.
Length = 2341
Score = 133 bits (322), Expect = 1e-30
Identities = 125/408 (30%), Positives = 183/408 (44%), Gaps = 43/408 (10%)
Query: 12 PFESITDMMYLGSGAQGVVYSGNL-------RGEM-VAVKKLR----EKEETDIM---HL 56
P E +T + LGSGA G VY G GE+ VAVK L+ ++E+ + + HL
Sbjct: 1935 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 1994
Query: 57 R-KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTPRQIIRWA 108
K NH NI++ GVC E II+E + G L +L G T ++
Sbjct: 1995 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 2054
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSRE-WDNESAVMSFT 162
DI++G VYL IHRDL + N LV+ + K+ DFG +R+ + N+
Sbjct: 2055 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 2114
Query: 163 GT--VAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETIL 219
G V WMAPE + + + DVWSFG+++WE+LT PY +L V T L
Sbjct: 2115 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 2174
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEF-SRVLPDRFSVTQA-TW 277
P P +CP+ L L+ QCW + P RP F I L + F + + R +
Sbjct: 2175 EP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI 2233
Query: 278 RKEIENEMKEIYTRNKEKFEQAQKLQSVRREELR---LARDTRLIYEQQLSRANELYMEV 334
+ E E ++ N + +++ RE L LA + E+ E
Sbjct: 2234 NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESES 2293
Query: 335 CAVRLQLEQKEKHLDE---REKALKLCRCGLRKTLKYYQRQNSSSSDG 379
C +R E+KE H D+ +EK + C G + L Y +S DG
Sbjct: 2294 CGLR--KEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDG 2339
>X16416-1|CAA34438.1| 1130|Homo sapiens protein ( Human c-abl mRNA
encoding p150 protein. ).
Length = 1130
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 293 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 412
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 413 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 471
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 472 MRACWQWNPSDRPSF 486
>U07563-2|AAB60394.1| 1130|Homo sapiens proto-oncogene
tyrosine-protein kinase protein.
Length = 1130
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 293 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 412
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 413 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 471
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 472 MRACWQWNPSDRPSF 486
>U07563-1|AAB60393.1| 1149|Homo sapiens proto-oncogene
tyrosine-protein kinase protein.
Length = 1149
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 431
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 432 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 490
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 491 MRACWQWNPSDRPSF 505
>M14752-1|AAA51561.1| 1130|Homo sapiens ABL1 protein.
Length = 1130
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 293 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 412
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 413 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDRSQV-YELLEKDYRMKRPEGCPEKVYEL 471
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 472 MRACWQWNPSDRPSF 486
>J05046-1|AAC31759.1| 1268|Homo sapiens insulin receptor-related
receptor protein.
Length = 1268
Score = 133 bits (321), Expect = 1e-30
Identities = 97/277 (35%), Positives = 140/277 (50%), Gaps = 34/277 (12%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRG-------EMVAVKKLREK----------E 49
++WEVP E I+ + LG G+ G+VY G RG VA+K + E +
Sbjct: 941 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1000
Query: 50 ETDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTPR---- 102
E +M K +H +VR GV S+G+ +IME G L L S A P
Sbjct: 1001 EASVMKAFKCHH--VVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP 1058
Query: 103 ---QIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAV 158
++I+ A +IA GM YL K +HRDL + N +V+ + K+ DFG +R+ ++ +
Sbjct: 1059 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYR 1118
Query: 159 MSFTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGT 215
G V WMAPE ++ + DVWSFGVVLWE++T E PY+ L +L V
Sbjct: 1119 KGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMD 1178
Query: 216 ETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIIL 252
+L + CP L+ L+++CW PR RP F IL
Sbjct: 1179 GGVLEEL-EGCPLQLQELMSRCWQPNPRLRPSFTHIL 1214
>DQ145721-1|AAZ38718.1| 1149|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 protein.
Length = 1149
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 431
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 432 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 490
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 491 MRACWQWNPSDRPSF 505
>BC117451-1|AAI17452.1| 1149|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 protein.
Length = 1149
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 431
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 432 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 490
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 491 MRACWQWNPSDRPSF 505
>AL359092-11|CAM45752.1| 1149|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 protein.
Length = 1149
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 431
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 432 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 490
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 491 MRACWQWNPSDRPSF 505
>AL161733-3|CAM45756.1| 1149|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 protein.
Length = 1149
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 252 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 312 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 371
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 372 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 431
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 432 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 490
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 491 MRACWQWNPSDRPSF 505
>AL161733-1|CAM45754.1| 1130|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 protein.
Length = 1130
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 233 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 292
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 293 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 412
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 413 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 471
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 472 MRACWQWNPSDRPSF 486
>AL158169-3|CAH70009.1| 1297|Homo sapiens insulin receptor-related
receptor protein.
Length = 1297
Score = 133 bits (321), Expect = 1e-30
Identities = 97/277 (35%), Positives = 140/277 (50%), Gaps = 34/277 (12%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRG-------EMVAVKKLREK----------E 49
++WEVP E I+ + LG G+ G+VY G RG VA+K + E +
Sbjct: 970 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1029
Query: 50 ETDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTPR---- 102
E +M K +H +VR GV S+G+ +IME G L L S A P
Sbjct: 1030 EASVMKAFKCHH--VVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP 1087
Query: 103 ---QIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAV 158
++I+ A +IA GM YL K +HRDL + N +V+ + K+ DFG +R+ ++ +
Sbjct: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYR 1147
Query: 159 MSFTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGT 215
G V WMAPE ++ + DVWSFGVVLWE++T E PY+ L +L V
Sbjct: 1148 KGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMD 1207
Query: 216 ETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIIL 252
+L + CP L+ L+++CW PR RP F IL
Sbjct: 1208 GGVLEEL-EGCPLQLQELMSRCWQPNPRLRPSFTHIL 1243
>AB209456-1|BAD92693.1| 1167|Homo sapiens v-abl Abelson murine
leukemia viral oncogene homolog 1 isoform b variant
protein.
Length = 1167
Score = 133 bits (321), Expect = 1e-30
Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK----EE--TDIMHLRK 58
+ WE+ IT LG G G VY G + VAVK L+E EE + +++
Sbjct: 270 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 329
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
+ H N+V+ GVC+ + II EF YG L D+L + ++ A I+ M
Sbjct: 330 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 389
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL + IHRDL + N LV +N + KV+DFG SR D +A + W APE +
Sbjct: 390 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 449
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVW+FGV+LWE+ T + PY ++ + + + + + P CPE + L
Sbjct: 450 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYEL 508
Query: 234 LNQCWDRVPRNRPPF 248
+ CW P +RP F
Sbjct: 509 MRACWQWNPSDRPSF 523
>Z27409-1|CAA81796.1| 691|Homo sapiens receptor tyrosine kinase eph
protein.
Length = 691
Score = 132 bits (320), Expect = 2e-30
Identities = 84/253 (33%), Positives = 123/253 (48%), Gaps = 19/253 (7%)
Query: 22 LGSGAQGVVYSGNLR-----GEMVAVKKLREKEE--------TDIMHLRKLNHDNIVRFR 68
+G G G VY G LR + VA+K L++ + + + +H +I+
Sbjct: 345 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 404
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II EF + G L FL P Q++ + IA GM YL N +HRD
Sbjct: 405 GVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRD 464
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEPCSERVDV 184
L + N+LV NL KVSDFG +R D+ G + W APE I H + DV
Sbjct: 465 LAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDV 524
Query: 185 WSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
WSFG+V+WE+L+ + PY + ++ + + LP P CP L L+ CW
Sbjct: 525 WSFGIVMWEVLSFGDKPYGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRA 583
Query: 244 NRPPFKIILAHLD 256
RP F+ + AHL+
Sbjct: 584 RRPHFQKLQAHLE 596
>U07695-1|AAA20598.1| 987|Homo sapiens tyrosine kinase protein.
Length = 987
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 740
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 741 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 800
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 801 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 859
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 860 DRNARPRFPQVVSALD 875
>BC130291-1|AAI30292.1| 976|Homo sapiens EPH receptor A1 protein.
Length = 976
Score = 132 bits (320), Expect = 2e-30
Identities = 84/253 (33%), Positives = 123/253 (48%), Gaps = 19/253 (7%)
Query: 22 LGSGAQGVVYSGNLR-----GEMVAVKKLREKEE--------TDIMHLRKLNHDNIVRFR 68
+G G G VY G LR + VA+K L++ + + + +H +I+
Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 689
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II EF + G L FL P Q++ + IA GM YL N +HRD
Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRD 749
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEPCSERVDV 184
L + N+LV NL KVSDFG +R D+ G + W APE I H + DV
Sbjct: 750 LAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDV 809
Query: 185 WSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
WSFG+V+WE+L+ + PY + ++ + + LP P CP L L+ CW
Sbjct: 810 WSFGIVMWEVLSFGDKPYGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRA 868
Query: 244 NRPPFKIILAHLD 256
RP F+ + AHL+
Sbjct: 869 RRPHFQKLQAHLE 881
>BC052804-1|AAH52804.1| 987|Homo sapiens EPH receptor B4 protein.
Length = 987
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 740
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 741 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 800
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 801 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 859
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 860 DRNARPRFPQVVSALD 875
>BC004264-1|AAH04264.1| 845|Homo sapiens EPHB4 protein protein.
Length = 845
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 479 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 538
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 539 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 598
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 599 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 658
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 659 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 717
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 718 DRNARPRFPQVVSALD 733
>AY056048-1|AAL14195.1| 935|Homo sapiens receptor protein tyrosine
kinase variant EphB4v1 protein.
Length = 935
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 740
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 741 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 800
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 801 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 859
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 860 DRNARPRFPQVVSALD 875
>AY056047-1|AAL14194.1| 987|Homo sapiens receptor protein tyrosine
kinase EphB4 protein.
Length = 987
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 740
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 741 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 800
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 801 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 859
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 860 DRNARPRFPQVVSALD 875
>AF312032-8|AAK21010.1| 987|Homo sapiens ephrin type-B receptor 4
precursor protein.
Length = 987
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 740
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 741 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 800
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 801 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 859
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 860 DRNARPRFPQVVSALD 875
>AF101171-1|AAD43440.1| 976|Homo sapiens receptor tyrosine kinase
protein.
Length = 976
Score = 132 bits (320), Expect = 2e-30
Identities = 84/253 (33%), Positives = 123/253 (48%), Gaps = 19/253 (7%)
Query: 22 LGSGAQGVVYSGNLR-----GEMVAVKKLREKEE--------TDIMHLRKLNHDNIVRFR 68
+G G G VY G LR + VA+K L++ + + + +H +I+
Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 689
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II EF + G L FL P Q++ + IA GM YL N +HRD
Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRD 749
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEPCSERVDV 184
L + N+LV NL KVSDFG +R D+ G + W APE I H + DV
Sbjct: 750 LAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDV 809
Query: 185 WSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
WSFG+V+WE+L+ + PY + ++ + + LP P CP L L+ CW
Sbjct: 810 WSFGIVMWEVLSFGDKPYGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRA 868
Query: 244 NRPPFKIILAHLD 256
RP F+ + AHL+
Sbjct: 869 RRPHFQKLQAHLE 881
>AC092214-2|AAS07458.1| 976|Homo sapiens unknown protein.
Length = 976
Score = 132 bits (320), Expect = 2e-30
Identities = 84/253 (33%), Positives = 123/253 (48%), Gaps = 19/253 (7%)
Query: 22 LGSGAQGVVYSGNLR-----GEMVAVKKLREKEE--------TDIMHLRKLNHDNIVRFR 68
+G G G VY G LR + VA+K L++ + + + +H +I+
Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLE 689
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV ++ + II EF + G L FL P Q++ + IA GM YL N +HRD
Sbjct: 690 GVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRD 749
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEPCSERVDV 184
L + N+LV NL KVSDFG +R D+ G + W APE I H + DV
Sbjct: 750 LAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDV 809
Query: 185 WSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
WSFG+V+WE+L+ + PY + ++ + + LP P CP L L+ CW
Sbjct: 810 WSFGIVMWEVLSFGDKPYGEMSNQEVMKSI-EDGYRLPPPVDCPAPLYELMKNCWAYDRA 868
Query: 244 NRPPFKIILAHLD 256
RP F+ + AHL+
Sbjct: 869 RRPHFQKLQAHLE 881
>AB209644-1|BAD92881.1| 986|Homo sapiens ephrin receptor EphB4
precursor variant protein.
Length = 986
Score = 132 bits (320), Expect = 2e-30
Identities = 83/256 (32%), Positives = 128/256 (50%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNLRG-----EMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L+ VA+K L+ E++ + + + + H NI+R
Sbjct: 620 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 679
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + I+ EF + G L FL + FT Q++ + IA GM YL +HRD
Sbjct: 680 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 739
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR + S+ ++T + + W APE I +
Sbjct: 740 LAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSA 799
Query: 182 VDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
D WS+G+V+WE+++ E PY + ++ + + LP P CP SL L+ CW +
Sbjct: 800 SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPPDCPTSLHQLMLDCWQK 858
Query: 241 VPRNRPPFKIILAHLD 256
RP F +++ LD
Sbjct: 859 DRNARPRFPQVVSALD 874
>DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 132 bits (319), Expect = 3e-30
Identities = 86/254 (33%), Positives = 134/254 (52%), Gaps = 21/254 (8%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLR-----EKEETD-----IMHLRKLNHDNIVRFRGVC 71
+GSG+ G VY G R ++VA+K+ R K + D + L +LNH +++F G C
Sbjct: 469 IGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGAC 528
Query: 72 -SEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI-IRWAKDIAQGMVYLHN--RKIIHRD 127
++ + I+ ++ G L+ LH Q + A D+A+GM YLHN + IIHRD
Sbjct: 529 LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRD 588
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDN--ESAVMSFTGTVAWMAPEVIRHEPCSE---RV 182
L S N+L+ ++ A V+DFG SR + E + G + WMAPEV C+ +
Sbjct: 589 LNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ--CTRYTIKA 646
Query: 183 DVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVP 242
DV+S+ + LWE+LT EIP+ L+ A + I P+ S P+ + LL + W+ P
Sbjct: 647 DVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACP 706
Query: 243 RNRPPFKIILAHLD 256
RP F ++ L+
Sbjct: 707 EGRPEFSEVVMKLE 720
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.135 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 71,073,809
Number of Sequences: 224733
Number of extensions: 3057363
Number of successful extensions: 17706
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2491
Number of HSP's successfully gapped in prelim test: 524
Number of HSP's that attempted gapping in prelim test: 9595
Number of HSP's gapped (non-prelim): 3992
length of query: 470
length of database: 73,234,838
effective HSP length: 93
effective length of query: 377
effective length of database: 52,334,669
effective search space: 19730170213
effective search space used: 19730170213
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)
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