Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002032-TA|BGIBMGA002032-PA|IPR008271|Serine/threonine
protein kinase, active site, IPR000719|Protein kinase,
IPR002290|Serine/threonine protein kinase, IPR001245|Tyrosine protein
kinase, IPR011009|Protein kinase-like
(470 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000DB7B8A Cluster: PREDICTED: similar to CG8789-PA,... 440 e-122
UniRef50_Q16RU6 Cluster: Mitogen-activated protein kinase kinase... 433 e-120
UniRef50_Q9VW24 Cluster: CG8789-PA, isoform A; n=3; Diptera|Rep:... 429 e-119
UniRef50_UPI00015B628A Cluster: PREDICTED: similar to LD14856p; ... 429 e-118
UniRef50_UPI0000585FA7 Cluster: PREDICTED: similar to leucine zi... 424 e-117
UniRef50_Q4S5N1 Cluster: Chromosome 9 SCAF14729, whole genome sh... 423 e-117
UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase... 415 e-114
UniRef50_O43283 Cluster: Mitogen-activated protein kinase kinase... 414 e-114
UniRef50_Q4RX00 Cluster: Chromosome 11 SCAF14979, whole genome s... 407 e-112
UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,... 361 3e-98
UniRef50_O01700 Cluster: Putative uncharacterized protein dlk-1;... 312 2e-83
UniRef50_UPI0001555434 Cluster: PREDICTED: similar to mitogen-ac... 305 2e-81
UniRef50_Q16584 Cluster: Mitogen-activated protein kinase kinase... 225 1e-57
UniRef50_Q02779 Cluster: Mitogen-activated protein kinase kinase... 223 8e-57
UniRef50_UPI0000F1F986 Cluster: PREDICTED: similar to mixed line... 219 2e-55
UniRef50_UPI00015535B8 Cluster: PREDICTED: similar to mixed line... 216 9e-55
UniRef50_P80192 Cluster: Mitogen-activated protein kinase kinase... 215 2e-54
UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 215 3e-54
UniRef50_Q3U1V8 Cluster: Mitogen-activated protein kinase kinase... 215 3e-54
UniRef50_Q9NYL2 Cluster: Mitogen-activated protein kinase kinase... 213 1e-53
UniRef50_Q95UN8 Cluster: Mitogen-activated protein kinase kinase... 211 3e-53
UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed line... 210 8e-53
UniRef50_Q4T6K1 Cluster: Chromosome undetermined SCAF8722, whole... 209 1e-52
UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;... 209 1e-52
UniRef50_Q5TCX8 Cluster: Mitogen-activated protein kinase kinase... 208 2e-52
UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to mitogen-ac... 208 3e-52
UniRef50_UPI000065D0F4 Cluster: Mitogen-activated protein kinase... 205 2e-51
UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep: EDR1... 203 9e-51
UniRef50_Q4H377 Cluster: Mitogen-activated protein kinase kinase... 199 1e-49
UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genom... 181 3e-44
UniRef50_Q0IPW2 Cluster: Os12g0163800 protein; n=7; Magnoliophyt... 179 1e-43
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 177 4e-43
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 176 9e-43
UniRef50_UPI000155F437 Cluster: PREDICTED: similar to Mitogen ac... 175 2e-42
UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole gen... 174 5e-42
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 173 6e-42
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 173 1e-41
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 173 1e-41
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 172 1e-41
UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core eu... 170 6e-41
UniRef50_A7R2R7 Cluster: Chromosome chr4 scaffold_443, whole gen... 169 1e-40
UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1; Trichom... 169 2e-40
UniRef50_Q9ZSD8 Cluster: Ethylene-inducible CTR1-like protein ki... 168 2e-40
UniRef50_Q9LYI8 Cluster: MAP3K delta-1 protein kinase; n=3; Arab... 168 2e-40
UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=... 168 2e-40
UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1; n... 168 2e-40
UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein;... 168 3e-40
UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum lycopersicu... 167 4e-40
UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole gen... 167 7e-40
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 165 2e-39
UniRef50_A0CL90 Cluster: Chromosome undetermined scaffold_20, wh... 164 4e-39
UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677; ... 163 9e-39
UniRef50_Q0IZJ5 Cluster: Os09g0566500 protein; n=9; Magnoliophyt... 163 9e-39
UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core eud... 163 1e-38
UniRef50_Q01JS4 Cluster: OSIGBa0152L12.10 protein; n=4; Oryza sa... 163 1e-38
UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:... 162 2e-38
UniRef50_Q54U31 Cluster: SH2 domain-containing protein; n=1; Dic... 162 2e-38
UniRef50_Q5CVX5 Cluster: Ser/Thr protein kinase with MORN repeat... 162 2e-38
UniRef50_UPI00015B574B Cluster: PREDICTED: hypothetical protein;... 161 3e-38
UniRef50_Q9FGZ6 Cluster: Protein kinase; n=3; Arabidopsis thalia... 161 3e-38
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 161 3e-38
UniRef50_A2DZZ0 Cluster: TKL family protein kinase; n=1; Trichom... 161 3e-38
UniRef50_A0D9Q7 Cluster: Chromosome undetermined scaffold_42, wh... 161 3e-38
UniRef50_P18161 Cluster: Tyrosine-protein kinase 2; n=2; Dictyos... 161 3e-38
UniRef50_Q5W6K6 Cluster: Kinase domain containing protein; n=2; ... 161 5e-38
UniRef50_Q54TA1 Cluster: E set domain-containing protein; n=1; D... 161 5e-38
UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1; Dictyos... 160 8e-38
UniRef50_P15056 Cluster: B-Raf proto-oncogene serine/threonine-p... 159 1e-37
UniRef50_UPI0000D56D6B Cluster: PREDICTED: similar to Mitogen-ac... 159 1e-37
UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2; ... 158 3e-37
UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole gen... 158 3e-37
UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Or... 158 3e-37
UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Tritic... 158 3e-37
UniRef50_UPI0000DB7E21 Cluster: PREDICTED: similar to Mitogen-ac... 157 4e-37
UniRef50_P04049 Cluster: RAF proto-oncogene serine/threonine-pro... 157 6e-37
UniRef50_Q173R9 Cluster: Tak1; n=1; Aedes aegypti|Rep: Tak1 - Ae... 157 8e-37
UniRef50_A2FSF7 Cluster: TKL family protein kinase; n=1; Trichom... 157 8e-37
UniRef50_A0C299 Cluster: Chromosome undetermined scaffold_144, w... 156 1e-36
UniRef50_Q9C547 Cluster: Protein kinase, putative; 12576-15979; ... 155 2e-36
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 155 2e-36
UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1; Trichom... 155 3e-36
UniRef50_A4S4M0 Cluster: Predicted protein; n=1; Ostreococcus lu... 154 4e-36
UniRef50_A2FGN8 Cluster: TKL family protein kinase; n=2; Trichom... 154 4e-36
UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1; Trichom... 154 4e-36
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 154 4e-36
UniRef50_A2E2L8 Cluster: TKL family protein kinase; n=1; Trichom... 154 5e-36
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 154 5e-36
UniRef50_P83104 Cluster: Putative mitogen-activated protein kina... 153 7e-36
UniRef50_Q4H2Q7 Cluster: Mitogen-activated protein kinase kinase... 153 1e-35
UniRef50_O43318 Cluster: Mitogen-activated protein kinase kinase... 153 1e-35
UniRef50_Q6ER39 Cluster: CTR1-like kinase kinase kinase-like; n=... 153 1e-35
UniRef50_Q0IR49 Cluster: Os11g0678000 protein; n=7; Oryza sativa... 153 1e-35
UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1; Dictyos... 153 1e-35
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 153 1e-35
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 152 2e-35
UniRef50_A2EAR6 Cluster: TKL family protein kinase; n=1; Trichom... 152 2e-35
UniRef50_Q9FRR5 Cluster: F22O13.20; n=37; Eukaryota|Rep: F22O13.... 151 5e-35
UniRef50_A7QMH3 Cluster: Chromosome chr19 scaffold_126, whole ge... 151 5e-35
UniRef50_Q9LRY7 Cluster: Similarity to protein kinase; n=3; Arab... 150 7e-35
UniRef50_P11346 Cluster: Raf homolog serine/threonine-protein ki... 150 7e-35
UniRef50_Q5XTZ4 Cluster: Salt-inducible protein kinase; n=2; Poa... 150 9e-35
UniRef50_Q0DE32 Cluster: Os06g0181200 protein; n=5; Oryza sativa... 150 9e-35
UniRef50_O64768 Cluster: Putative uncharacterized protein At2g35... 150 9e-35
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 150 9e-35
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 150 9e-35
UniRef50_UPI00015B4F3C Cluster: PREDICTED: similar to CG2845-PA;... 149 1e-34
UniRef50_Q7ZTR8 Cluster: Serine/Threonine protein kinase RAF1; n... 149 1e-34
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 149 1e-34
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 149 1e-34
UniRef50_A0E8G3 Cluster: Chromosome undetermined scaffold_82, wh... 149 2e-34
UniRef50_A2E1W1 Cluster: TKL family protein kinase; n=1; Trichom... 148 3e-34
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 148 3e-34
UniRef50_Q94AB2 Cluster: AT3g58640/F14P22_230; n=13; Magnoliophy... 148 4e-34
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 148 4e-34
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 148 4e-34
UniRef50_Q67W58 Cluster: Putative ethylene-inducible CTR1-like p... 147 5e-34
UniRef50_A2DSI0 Cluster: TKL family protein kinase; n=2; Trichom... 147 5e-34
UniRef50_A0DRH3 Cluster: Chromosome undetermined scaffold_60, wh... 147 5e-34
UniRef50_Q4RNI1 Cluster: Chromosome undetermined SCAF15013, whol... 147 6e-34
UniRef50_Q554C0 Cluster: LISK family protein kinase; n=2; Dictyo... 147 6e-34
UniRef50_Q54R58 Cluster: WD-40 repeat-containing protein; n=1; D... 147 6e-34
UniRef50_Q4H2W3 Cluster: Serine/threonine protein kinase; n=1; C... 147 6e-34
UniRef50_Q0GU41 Cluster: TGF beta-activated kinase; n=4; Eumetaz... 147 6e-34
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 147 6e-34
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 146 8e-34
UniRef50_Q54IP4 Cluster: SH2 domain-containing protein; n=1; Dic... 146 8e-34
UniRef50_Q23AD7 Cluster: Protein kinase domain containing protei... 146 1e-33
UniRef50_A2DH69 Cluster: TKL family protein kinase; n=1; Trichom... 146 1e-33
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 146 1e-33
UniRef50_Q9SZM7 Cluster: Protein kinase like protein; n=1; Arabi... 146 1e-33
UniRef50_Q55A09 Cluster: Kelch repeat-containing protein; n=4; D... 146 1e-33
UniRef50_A2FSI4 Cluster: TKL family protein kinase; n=1; Trichom... 146 1e-33
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 145 2e-33
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 145 2e-33
UniRef50_Q54Y55 Cluster: SH2 domain-containing protein; n=1; Dic... 145 2e-33
UniRef50_A2G0Z0 Cluster: TKL family protein kinase; n=2; Trichom... 145 2e-33
UniRef50_A2FUX6 Cluster: TKL family protein kinase; n=1; Trichom... 145 2e-33
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 145 3e-33
UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated ... 145 3e-33
UniRef50_A2DI38 Cluster: TKL family protein kinase; n=2; Trichom... 145 3e-33
UniRef50_A0CTK9 Cluster: Chromosome undetermined scaffold_27, wh... 145 3e-33
UniRef50_A2FNV5 Cluster: TKL family protein kinase; n=1; Trichom... 144 3e-33
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 144 3e-33
UniRef50_Q4SPJ8 Cluster: Chromosome 16 SCAF14537, whole genome s... 144 4e-33
UniRef50_Q9STG4 Cluster: Putative uncharacterized protein T6H20.... 144 4e-33
UniRef50_A2DAP2 Cluster: TKL family protein kinase; n=1; Trichom... 144 4e-33
UniRef50_UPI0000D572D6 Cluster: PREDICTED: similar to CG2845-PA;... 144 6e-33
UniRef50_UPI000049A3B4 Cluster: protein kinase; n=1; Entamoeba h... 144 6e-33
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 144 6e-33
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 144 6e-33
UniRef50_Q55GE6 Cluster: WD40 repeat-containing protein; n=2; Di... 144 6e-33
UniRef50_Q23K41 Cluster: Protein kinase domain containing protei... 144 6e-33
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 144 6e-33
UniRef50_Q9V3Q6 Cluster: Mitogen-activated protein kinase kinase... 144 6e-33
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 144 6e-33
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 143 8e-33
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 143 8e-33
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 143 1e-32
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 143 1e-32
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 143 1e-32
UniRef50_UPI0000498D53 Cluster: protein kinase; n=1; Entamoeba h... 142 1e-32
UniRef50_Q55AN7 Cluster: SMAD/FHA domain-containing protein; n=2... 142 1e-32
UniRef50_A2FUJ1 Cluster: TKL family protein kinase; n=1; Trichom... 142 1e-32
UniRef50_A7NXT1 Cluster: Chromosome chr5 scaffold_2, whole genom... 142 2e-32
UniRef50_A2E4G1 Cluster: TKL family protein kinase; n=1; Trichom... 142 2e-32
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 142 2e-32
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 142 2e-32
UniRef50_Q9SA26 Cluster: F3O9.7 protein; n=3; Arabidopsis thalia... 141 3e-32
UniRef50_A2ETT9 Cluster: TKL family protein kinase; n=1; Trichom... 141 3e-32
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 141 3e-32
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 141 3e-32
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 141 4e-32
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 141 4e-32
UniRef50_Q5K4U1 Cluster: LIN-45 RAF; n=1; Meloidogyne artiellia|... 141 4e-32
UniRef50_Q54XQ2 Cluster: RGS domain-containing protein; n=2; Dic... 141 4e-32
UniRef50_A2DQD6 Cluster: TKL family protein kinase; n=1; Trichom... 141 4e-32
UniRef50_A0DHI3 Cluster: Chromosome undetermined scaffold_50, wh... 141 4e-32
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 141 4e-32
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 141 4e-32
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 141 4e-32
UniRef50_Q5FBD1 Cluster: Serine/threonine protein kinase ARAF; n... 140 5e-32
UniRef50_Q9SAJ2 Cluster: T8K14.1 protein; n=3; Arabidopsis thali... 140 5e-32
UniRef50_A4SBG1 Cluster: Predicted protein; n=2; Ostreococcus|Re... 140 5e-32
UniRef50_Q54TH6 Cluster: LISK family protein kinase; n=1; Dictyo... 140 5e-32
UniRef50_Q019B0 Cluster: Tyrosine kinase specific for activated ... 140 7e-32
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 140 7e-32
UniRef50_A2E0X6 Cluster: TKL family protein kinase; n=1; Trichom... 140 7e-32
UniRef50_UPI00006CE4F4 Cluster: Protein kinase domain containing... 140 1e-31
UniRef50_UPI00004986C0 Cluster: protein kinase; n=1; Entamoeba h... 140 1e-31
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 140 1e-31
UniRef50_A7QS17 Cluster: Chromosome undetermined scaffold_155, w... 140 1e-31
UniRef50_A5AQH5 Cluster: Putative uncharacterized protein; n=1; ... 140 1e-31
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 140 1e-31
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 140 1e-31
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 140 1e-31
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 139 1e-31
UniRef50_Q9STU7 Cluster: Putative uncharacterized protein T22A6.... 139 1e-31
UniRef50_Q23927 Cluster: Protein tyrosine kinase; n=3; Dictyoste... 139 1e-31
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 139 1e-31
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 139 1e-31
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 139 1e-31
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 139 2e-31
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 139 2e-31
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 138 2e-31
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 138 2e-31
UniRef50_A2FIB7 Cluster: CAMK family protein kinase; n=1; Tricho... 138 2e-31
UniRef50_A2FDP2 Cluster: TKL family protein kinase; n=3; Trichom... 138 2e-31
UniRef50_A2EJW7 Cluster: TKL family protein kinase; n=1; Trichom... 138 2e-31
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 138 2e-31
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 138 2e-31
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 138 3e-31
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 138 3e-31
UniRef50_A2EC73 Cluster: TKL family protein kinase; n=1; Trichom... 138 3e-31
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 138 4e-31
UniRef50_A2DK06 Cluster: TKL family protein kinase; n=1; Trichom... 138 4e-31
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 137 5e-31
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 137 7e-31
UniRef50_A7PBE5 Cluster: Chromosome chr16 scaffold_10, whole gen... 137 7e-31
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 137 7e-31
UniRef50_A7RN75 Cluster: Predicted protein; n=2; Nematostella ve... 137 7e-31
UniRef50_A7TJU8 Cluster: Putative uncharacterized protein; n=1; ... 137 7e-31
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 137 7e-31
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 136 9e-31
UniRef50_Q54L00 Cluster: Zn binding domain-containing protein; n... 136 9e-31
UniRef50_A2F251 Cluster: TKL family protein kinase; n=1; Trichom... 136 9e-31
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 136 9e-31
UniRef50_UPI0000498E32 Cluster: protein kinase; n=2; Entamoeba h... 136 1e-30
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 136 1e-30
UniRef50_Q55EI8 Cluster: Filamin/ABP280 repeat-containing protei... 136 1e-30
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 136 2e-30
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 136 2e-30
UniRef50_Q9BI25 Cluster: SHK1 protein; n=2; Dictyostelium discoi... 135 2e-30
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 135 2e-30
UniRef50_A2FEP9 Cluster: TKL family protein kinase; n=1; Trichom... 135 2e-30
UniRef50_Q8LCP3 Cluster: ATMRK1; n=27; Magnoliophyta|Rep: ATMRK1... 135 3e-30
UniRef50_A7Q6K4 Cluster: Chromosome chr11 scaffold_56, whole gen... 135 3e-30
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 135 3e-30
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 135 3e-30
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 135 3e-30
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 134 4e-30
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 134 5e-30
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 134 5e-30
UniRef50_Q6A1B3 Cluster: Raf serine/threonine kinase; n=1; Echin... 134 5e-30
UniRef50_A5DTE9 Cluster: Putative uncharacterized protein; n=1; ... 134 5e-30
UniRef50_P18160 Cluster: Non-receptor tyrosine kinase spore lysi... 134 5e-30
UniRef50_Q9FKL3 Cluster: Similarity to protein kinase; n=1; Arab... 134 6e-30
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 134 6e-30
UniRef50_Q54L02 Cluster: LIM domain-containing protein; n=1; Dic... 134 6e-30
UniRef50_A2DNM3 Cluster: TKL family protein kinase; n=1; Trichom... 134 6e-30
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 133 8e-30
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 133 8e-30
UniRef50_Q9LMF8 Cluster: F16A14.22; n=9; Magnoliophyta|Rep: F16A... 133 8e-30
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 133 8e-30
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 133 8e-30
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 133 8e-30
UniRef50_Q8L650 Cluster: Putative uncharacterized protein B1015E... 133 1e-29
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 133 1e-29
UniRef50_A2EY26 Cluster: TKL family protein kinase; n=2; Trichom... 133 1e-29
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 133 1e-29
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 133 1e-29
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 133 1e-29
UniRef50_Q54PX0 Cluster: Putative uncharacterized protein; n=1; ... 132 1e-29
UniRef50_A2FY37 Cluster: TKL family protein kinase; n=1; Trichom... 132 1e-29
UniRef50_A2FG05 Cluster: TKL family protein kinase; n=1; Trichom... 132 1e-29
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 132 1e-29
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 132 2e-29
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 132 2e-29
UniRef50_A2DRQ2 Cluster: TKL family protein kinase; n=1; Trichom... 132 2e-29
UniRef50_Q59H18 Cluster: Serine/threonine-protein kinase TNNI3K;... 132 2e-29
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 132 3e-29
UniRef50_P41892 Cluster: Cell division control protein 7; n=1; S... 132 3e-29
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 131 3e-29
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 131 3e-29
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 131 3e-29
UniRef50_A2EJ21 Cluster: TKL family protein kinase; n=1; Trichom... 131 3e-29
UniRef50_Q2QSC9 Cluster: Protein kinase domain containing protei... 131 4e-29
UniRef50_Q0J228 Cluster: Os09g0383300 protein; n=5; Oryza sativa... 131 4e-29
UniRef50_Q00SN3 Cluster: Protein kinase family protein; n=2; Ost... 131 4e-29
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 131 4e-29
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 130 6e-29
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 130 6e-29
UniRef50_Q55GG4 Cluster: RGS domain-containing protein; n=1; Dic... 130 6e-29
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 130 6e-29
UniRef50_UPI000049A26D Cluster: protein kinase; n=2; Entamoeba h... 130 8e-29
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 130 8e-29
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 130 8e-29
UniRef50_Q54RZ7 Cluster: MORN repeat-containing protein; n=1; Di... 130 8e-29
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 130 1e-28
UniRef50_A2FCV2 Cluster: TKL family protein kinase; n=1; Trichom... 130 1e-28
UniRef50_A2DBS6 Cluster: TKL family protein kinase; n=1; Trichom... 130 1e-28
UniRef50_A0BC68 Cluster: Chromosome undetermined scaffold_10, wh... 130 1e-28
UniRef50_Q9SX42 Cluster: F14I3.15 protein; n=2; Arabidopsis thal... 129 1e-28
UniRef50_Q2QAV0 Cluster: Fused; n=3; core eudicotyledons|Rep: Fu... 129 1e-28
UniRef50_Q55CA6 Cluster: Putative uncharacterized protein; n=1; ... 129 1e-28
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 129 1e-28
UniRef50_Q7Z8J5 Cluster: MAP kinase kinase kinase; n=1; Yarrowia... 129 1e-28
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 129 2e-28
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 129 2e-28
UniRef50_Q55DU7 Cluster: Putative transmembrane protein; n=2; Di... 129 2e-28
UniRef50_Q6FWK3 Cluster: Similar to sp|P27636 Saccharomyces cere... 129 2e-28
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 128 2e-28
UniRef50_UPI000049A56F Cluster: protein kinase; n=1; Entamoeba h... 128 2e-28
UniRef50_Q8W582 Cluster: At1g53570/F22G10_18; n=8; core eudicoty... 128 2e-28
UniRef50_Q55EC7 Cluster: RasGEF domain-containing protein; n=1; ... 128 2e-28
UniRef50_Q54R82 Cluster: Protein serine/threonine kinase; n=2; D... 128 2e-28
UniRef50_A2DZS9 Cluster: TKL family protein kinase; n=1; Trichom... 128 2e-28
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 128 2e-28
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 128 3e-28
UniRef50_Q23915 Cluster: Protein kinase; n=2; Dictyostelium disc... 128 3e-28
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 128 3e-28
UniRef50_O22040 Cluster: Mitogen-activated protein kinase kinase... 128 3e-28
UniRef50_UPI0000E7FBCB Cluster: PREDICTED: similar to NIMA (neve... 128 4e-28
UniRef50_Q7TSC3 Cluster: Serine/threonine-protein kinase Nek5; n... 128 4e-28
UniRef50_P27636 Cluster: Cell division control protein 15; n=3; ... 128 4e-28
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 127 5e-28
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 127 5e-28
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 127 5e-28
UniRef50_Q4PCB9 Cluster: Putative uncharacterized protein; n=1; ... 127 5e-28
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 127 7e-28
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 127 7e-28
UniRef50_Q54F62 Cluster: RasGEF domain-containing protein; n=2; ... 127 7e-28
UniRef50_A2FTS4 Cluster: CAMK family protein kinase; n=2; Tricho... 127 7e-28
UniRef50_A2DJ39 Cluster: TKL family protein kinase; n=1; Trichom... 127 7e-28
UniRef50_Q0USU3 Cluster: Putative uncharacterized protein; n=1; ... 127 7e-28
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 126 1e-27
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 126 1e-27
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 126 1e-27
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 126 1e-27
UniRef50_A7PSB1 Cluster: Chromosome chr14 scaffold_27, whole gen... 126 1e-27
UniRef50_A4S2A1 Cluster: Predicted protein; n=1; Ostreococcus lu... 126 1e-27
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 126 1e-27
UniRef50_Q54RV3 Cluster: Putative uncharacterized protein pakG; ... 126 1e-27
UniRef50_A2EIX4 Cluster: TKL family protein kinase; n=1; Trichom... 126 1e-27
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 126 2e-27
UniRef50_UPI0000498D43 Cluster: protein kinase; n=2; Entamoeba h... 126 2e-27
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 126 2e-27
UniRef50_A7NWI3 Cluster: Chromosome chr5 scaffold_2, whole genom... 126 2e-27
UniRef50_A2E409 Cluster: CAMK family protein kinase; n=1; Tricho... 126 2e-27
UniRef50_Q5KHJ6 Cluster: MAP kinase kinase kinase, putative; n=2... 126 2e-27
UniRef50_UPI0000ECD6BF Cluster: Serine/threonine-protein kinase ... 125 2e-27
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 125 2e-27
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 125 2e-27
UniRef50_Q54G43 Cluster: SH2 domain-containing protein; n=1; Dic... 125 2e-27
UniRef50_Q4DQP8 Cluster: Protein kinase-like protein, putative; ... 125 2e-27
UniRef50_O96197 Cluster: Protein kinase, putative; n=3; Plasmodi... 125 2e-27
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 125 2e-27
UniRef50_Q9LT56 Cluster: Nearly identical to protein kinase ATN1... 125 3e-27
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 125 3e-27
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 125 3e-27
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 125 3e-27
UniRef50_Q6CK22 Cluster: Similarity; n=2; Kluyveromyces lactis|R... 125 3e-27
UniRef50_Q6BV63 Cluster: Debaryomyces hansenii chromosome C of s... 125 3e-27
UniRef50_A5E6H6 Cluster: Putative uncharacterized protein; n=1; ... 125 3e-27
UniRef50_A2QHV0 Cluster: Contig An04c0070, complete genome; n=4;... 125 3e-27
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 125 3e-27
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 124 4e-27
UniRef50_Q5A5B8 Cluster: Likely protein kinase; n=1; Candida alb... 124 4e-27
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 124 4e-27
UniRef50_UPI000049A335 Cluster: protein kinase; n=2; Entamoeba h... 124 5e-27
UniRef50_UPI0000498967 Cluster: protein kinase; n=3; Entamoeba h... 124 5e-27
UniRef50_Q7XNU0 Cluster: OSJNba0093F12.18 protein; n=5; Oryza sa... 124 5e-27
UniRef50_A3C9K1 Cluster: Putative uncharacterized protein; n=1; ... 124 5e-27
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 124 5e-27
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 124 5e-27
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 124 5e-27
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 124 7e-27
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 124 7e-27
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 124 7e-27
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 123 9e-27
UniRef50_Q54Y90 Cluster: Protein kinase, TKL group; n=1; Dictyos... 123 9e-27
UniRef50_Q22AY1 Cluster: Protein kinase domain containing protei... 123 9e-27
UniRef50_Q756N1 Cluster: AER223Cp; n=1; Eremothecium gossypii|Re... 123 9e-27
UniRef50_Q4PAM9 Cluster: Putative uncharacterized protein; n=1; ... 123 9e-27
UniRef50_Q6P3R8 Cluster: Serine/threonine-protein kinase Nek5; n... 123 9e-27
UniRef50_UPI0000498450 Cluster: protein kinase; n=2; Entamoeba h... 123 1e-26
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 123 1e-26
UniRef50_Q55CZ1 Cluster: Putative transmembrane protein; n=1; Di... 123 1e-26
UniRef50_A2G5H7 Cluster: TKL family protein kinase; n=1; Trichom... 123 1e-26
UniRef50_A2DFT3 Cluster: TKL family protein kinase; n=1; Trichom... 123 1e-26
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 123 1e-26
UniRef50_Q0JAH8 Cluster: Os04g0598800 protein; n=2; Oryza sativa... 122 2e-26
UniRef50_Q551J3 Cluster: Putative uncharacterized protein; n=2; ... 122 2e-26
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 122 2e-26
UniRef50_A0BZ56 Cluster: Chromosome undetermined scaffold_138, w... 122 2e-26
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 122 2e-26
UniRef50_UPI0000F1FC64 Cluster: PREDICTED: hypothetical protein;... 122 2e-26
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 122 2e-26
UniRef50_UPI0000499E71 Cluster: protein kinase; n=1; Entamoeba h... 122 2e-26
UniRef50_UPI00004997A6 Cluster: protein kinase; n=7; Entamoeba h... 122 2e-26
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 122 2e-26
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 122 2e-26
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 122 2e-26
UniRef50_A2FJX1 Cluster: TKL family protein kinase; n=1; Trichom... 122 2e-26
UniRef50_Q754I4 Cluster: AFR092Wp; n=2; root|Rep: AFR092Wp - Ash... 122 2e-26
UniRef50_UPI0000D5663C Cluster: PREDICTED: similar to CG1848-PA,... 122 3e-26
UniRef50_UPI00006CB3C4 Cluster: Protein kinase domain containing... 122 3e-26
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 122 3e-26
UniRef50_Q10NR1 Cluster: Mitogen-activated protein kinase 1, put... 122 3e-26
UniRef50_A5BLK5 Cluster: Putative uncharacterized protein; n=1; ... 122 3e-26
UniRef50_Q552C7 Cluster: Protein tyrosine kinase; n=5; Dictyoste... 122 3e-26
UniRef50_A4I4X5 Cluster: Serine/threonine-protein kinase Nek3, p... 122 3e-26
UniRef50_A2G058 Cluster: CAMK family protein kinase; n=3; Tricho... 122 3e-26
UniRef50_A2EGD0 Cluster: TKL family protein kinase; n=3; Trichom... 122 3e-26
UniRef50_Q07292 Cluster: Raf homolog serine/threonine-protein ki... 122 3e-26
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 121 4e-26
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 121 4e-26
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 121 4e-26
UniRef50_Q9STE0 Cluster: MAP3K epsilon 1 protein kinase; n=1; Br... 121 4e-26
UniRef50_Q2QM74 Cluster: Protein kinase domain containing protei... 121 4e-26
UniRef50_A7PZD6 Cluster: Chromosome chr15 scaffold_40, whole gen... 121 4e-26
UniRef50_A4S4H8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 121 4e-26
UniRef50_Q4QGB0 Cluster: Mitogen-activated protein kinase kinase... 121 4e-26
UniRef50_Q23KJ6 Cluster: Protein kinase domain containing protei... 121 4e-26
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 121 4e-26
UniRef50_A0E7T5 Cluster: Chromosome undetermined scaffold_81, wh... 121 4e-26
UniRef50_UPI00004988DF Cluster: protein kinase; n=1; Entamoeba h... 121 5e-26
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 121 5e-26
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 121 5e-26
UniRef50_Q54JA1 Cluster: Leucine-rich repeat-containing protein;... 121 5e-26
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 121 5e-26
UniRef50_Q6FLG8 Cluster: Similar to sp|Q01389 Saccharomyces cere... 121 5e-26
UniRef50_Q56UN5 Cluster: SPS1/STE20-related protein kinase YSK4;... 121 5e-26
UniRef50_UPI000049958C Cluster: protein kinase; n=1; Entamoeba h... 120 6e-26
UniRef50_Q75I98 Cluster: Putative uncharacterized protein OSJNBa... 120 6e-26
UniRef50_Q4U3Z6 Cluster: Wall-associated kinase 3; n=3; BEP clad... 120 6e-26
UniRef50_A7NWZ2 Cluster: Chromosome chr5 scaffold_2, whole genom... 120 6e-26
UniRef50_Q584V3 Cluster: Protein kinase, putative; n=1; Trypanos... 120 6e-26
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 120 6e-26
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 120 6e-26
UniRef50_A2EB11 Cluster: CAMK family protein kinase; n=3; Tricho... 120 6e-26
UniRef50_UPI0000E809AA Cluster: PREDICTED: similar to regulated ... 120 8e-26
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 120 1e-25
UniRef50_UPI0000499A67 Cluster: protein kinase; n=1; Entamoeba h... 120 1e-25
UniRef50_A7P2X0 Cluster: Chromosome chr1 scaffold_5, whole genom... 120 1e-25
UniRef50_Q9GZG1 Cluster: Putative uncharacterized protein; n=6; ... 120 1e-25
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 120 1e-25
UniRef50_Q22AD4 Cluster: Protein kinase domain containing protei... 120 1e-25
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 120 1e-25
UniRef50_A2EJ56 Cluster: TKL family protein kinase; n=1; Trichom... 120 1e-25
UniRef50_Q39008 Cluster: Mitogen-activated protein kinase kinase... 120 1e-25
UniRef50_UPI000069FC64 Cluster: Serine/threonine-protein kinase ... 119 1e-25
UniRef50_UPI000069FC63 Cluster: Serine/threonine-protein kinase ... 119 1e-25
UniRef50_Q6GPK5 Cluster: Tyrosine-protein kinase; n=4; Euteleost... 119 1e-25
UniRef50_Q9FXD7 Cluster: F12A21.14; n=21; Magnoliophyta|Rep: F12... 119 1e-25
UniRef50_Q7FAF6 Cluster: OSJNba0093F12.22 protein; n=3; Oryza sa... 119 1e-25
UniRef50_Q0IZL6 Cluster: Os09g0562600 protein; n=7; Oryza sativa... 119 1e-25
UniRef50_A7NVK8 Cluster: Chromosome chr18 scaffold_1, whole geno... 119 1e-25
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 119 1e-25
UniRef50_Q54N73 Cluster: Putative transmembrane protein; n=1; Di... 119 1e-25
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 119 1e-25
UniRef50_A0C9W0 Cluster: Chromosome undetermined scaffold_16, wh... 119 1e-25
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 119 1e-25
UniRef50_Q9LMN8 Cluster: Wall-associated receptor kinase 3 precu... 119 1e-25
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 119 1e-25
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 119 2e-25
UniRef50_Q54QQ1 Cluster: Protein serine/threonine kinase; n=2; D... 119 2e-25
UniRef50_Q24DN1 Cluster: Protein kinase domain containing protei... 119 2e-25
UniRef50_Q229R8 Cluster: Protein kinase domain containing protei... 119 2e-25
UniRef50_Q228S4 Cluster: Protein kinase domain containing protei... 119 2e-25
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 119 2e-25
UniRef50_UPI0000499E92 Cluster: protein kinase; n=1; Entamoeba h... 118 3e-25
UniRef50_UPI0000498BDB Cluster: cell division control protein 7;... 118 3e-25
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 118 3e-25
UniRef50_Q7XTK4 Cluster: Putative mitogen-activated protein kina... 118 3e-25
UniRef50_Q0J4N7 Cluster: Os08g0501500 protein; n=3; Oryza sativa... 118 3e-25
UniRef50_Q01I65 Cluster: H0315A08.7 protein; n=8; Oryza sativa|R... 118 3e-25
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 118 3e-25
UniRef50_Q54VC0 Cluster: LISK family protein kinase; n=1; Dictyo... 118 3e-25
UniRef50_A2EVH8 Cluster: TKL family protein kinase; n=1; Trichom... 118 3e-25
UniRef50_A2EBK6 Cluster: TKL family protein kinase; n=1; Trichom... 118 3e-25
UniRef50_A2DGP4 Cluster: TKL family protein kinase; n=1; Trichom... 118 3e-25
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 118 3e-25
UniRef50_Q6C8H9 Cluster: Similar to tr|Q871H9 Neurospora crassa ... 118 3e-25
UniRef50_A3LSM4 Cluster: Predicted protein; n=1; Pichia stipitis... 118 3e-25
UniRef50_P29597 Cluster: Non-receptor tyrosine-protein kinase TY... 118 3e-25
UniRef50_UPI000049A0D5 Cluster: protein kinase; n=1; Entamoeba h... 118 3e-25
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 118 3e-25
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 118 3e-25
UniRef50_A7Q7R5 Cluster: Chromosome chr18 scaffold_61, whole gen... 118 3e-25
UniRef50_Q7R4U9 Cluster: GLP_440_20077_14564; n=1; Giardia lambl... 118 3e-25
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 118 3e-25
UniRef50_A2FGZ7 Cluster: TKL family protein kinase; n=1; Trichom... 118 3e-25
UniRef50_A2R1E1 Cluster: Contig An13c0040, complete genome; n=4;... 118 3e-25
UniRef50_Q10407 Cluster: MAP kinase kinase kinase mkh1; n=1; Sch... 118 3e-25
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 118 4e-25
UniRef50_A6YTD4 Cluster: NPK1-like kinase; n=1; Cucumis melo|Rep... 118 4e-25
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 118 4e-25
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 118 4e-25
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 118 4e-25
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 118 4e-25
UniRef50_UPI000049A2D4 Cluster: protein kinase; n=1; Entamoeba h... 117 6e-25
UniRef50_UPI0000499655 Cluster: protein kinase; n=2; Entamoeba h... 117 6e-25
UniRef50_A4S7Z1 Cluster: Predicted protein; n=2; Ostreococcus|Re... 117 6e-25
UniRef50_A2XA18 Cluster: Putative uncharacterized protein; n=2; ... 117 6e-25
UniRef50_Q388G0 Cluster: Protein kinase, putative; n=1; Trypanos... 117 6e-25
UniRef50_A5KC05 Cluster: Serine/threonine-specific protein kinas... 117 6e-25
UniRef50_Q6CVC4 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 117 6e-25
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 117 6e-25
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 117 6e-25
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 117 6e-25
>UniRef50_UPI0000DB7B8A Cluster: PREDICTED: similar to CG8789-PA,
isoform A; n=1; Apis mellifera|Rep: PREDICTED: similar
to CG8789-PA, isoform A - Apis mellifera
Length = 895
Score = 440 bits (1085), Expect = e-122
Identities = 208/383 (54%), Positives = 268/383 (69%), Gaps = 7/383 (1%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVR 66
+DWE+PFESI+++ +LGSGAQG V+SG L E+VAVKK+RE ETDI HLRKLNH NIV+
Sbjct: 140 DDWEIPFESISELQWLGSGAQGAVFSGKLNKEVVAVKKVREPRETDIRHLRKLNHPNIVQ 199
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
F+GVC++ YCIIMEFC YGPLYD L +G P +++ W+K IA GM YLH KIIHR
Sbjct: 200 FKGVCTQAPCYCIIMEFCPYGPLYDLLRAGEPVPPPRLVSWSKQIAAGMAYLHAHKIIHR 259
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLKSPNVL+ V K+SDFGTSREW+ S MSF GTVAWMAPE+IR+EPCSE+VD+WS
Sbjct: 260 DLKSPNVLIGQGEVVKISDFGTSREWNEISTRMSFAGTVAWMAPEIIRNEPCSEKVDIWS 319
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
+GVVLWELL+ EIPYK +++ AI+WGVG ++ LP+P SCPE +LL+ QCW PRNRP
Sbjct: 320 YGVVLWELLSGEIPYKDVDSSAIIWGVGNNSLHLPIPASCPEGYRLLVKQCWAAKPRNRP 379
Query: 247 PFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVR 306
FK I HL IA E PD + TQ +W+KEI + MK++ T + L R
Sbjct: 380 SFKHIEIHLGIAAVEVLCTKPDDYFKTQQSWKKEIRDHMKQMQTNSCSSPRFEADLIRRR 439
Query: 307 REELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREK--ALKLCRCGLRK 364
+ELR A+D R YE++L R N LY+E+ AV LQLEQ+E+ + +RE+ K C+ L
Sbjct: 440 EDELRHAQDIREHYERKLERTNNLYLELSAVLLQLEQRERDVIKREQQNGYKQCKKRLVH 499
Query: 365 TL-----KYYQRQNSSSSDGKSP 382
L + ++R+N S +P
Sbjct: 500 PLLKAQERLHRRRNPQFSTSSTP 522
>UniRef50_Q16RU6 Cluster: Mitogen-activated protein kinase kinase
kinase; n=1; Aedes aegypti|Rep: Mitogen-activated
protein kinase kinase kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 944
Score = 433 bits (1067), Expect = e-120
Identities = 197/383 (51%), Positives = 281/383 (73%), Gaps = 5/383 (1%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVR 66
+DWE+ F+SITDM ++GSGAQG V+ G L E+VAVKK+RE +ETDI HLRKL+H+NIV+
Sbjct: 62 DDWEISFDSITDMGWIGSGAQGAVFRGKLHNELVAVKKVREVKETDIKHLRKLDHENIVK 121
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ +CIIME+C +GPL+ L G +PR+++ W++ IA GM YLH+ KIIH
Sbjct: 122 FKGVCTQAPVFCIIMEYCPFGPLHHILADGMDIISPRRLVSWSQQIAHGMQYLHSHKIIH 181
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ADN V K+SDFGTSREW+ S MSF GTVAWMAPEVIR+EPC+E+VD+W
Sbjct: 182 RDLKSPNILIADNEVIKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCNEKVDIW 241
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
S+GVVLWELLT E+PYK +++ I++GVG ++ LP+P+SCPE KLL+ QCW PRNR
Sbjct: 242 SYGVVLWELLTCEVPYKNVDSSQIIFGVGNNSLYLPIPSSCPEGFKLLIKQCWSPKPRNR 301
Query: 246 PPFKIILAHLDIAGAE-FSRVLPDR-FSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQ 303
P FKIIL HL+IA E S+ ++ + TQ +WR+EI + M+++ + + + Q+L
Sbjct: 302 PSFKIILTHLEIASNELLSQCTEEQGYYETQKSWREEIRSHMQKLTSNGMDIQKYEQELI 361
Query: 304 SVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
R++E + A+D R++Y+++L R N +Y+++ A+ +QL+QKEK + EREK L + R
Sbjct: 362 KKRKDEWKHAQDIRMVYQRKLERTNTMYLQLSAIYVQLKQKEKEIAEREKQLPGYK--PR 419
Query: 364 KTLKYYQRQNSSSSDGKSPLEVI 386
K +R SS ++ + V+
Sbjct: 420 KCGNLLKRSGDKSSRKRAAVNVV 442
>UniRef50_Q9VW24 Cluster: CG8789-PA, isoform A; n=3; Diptera|Rep:
CG8789-PA, isoform A - Drosophila melanogaster (Fruit
fly)
Length = 977
Score = 429 bits (1058), Expect = e-119
Identities = 190/349 (54%), Positives = 256/349 (73%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVR 66
EDW++PFESIT++ +LGSGAQG V+SG L+ E VAVKK++E +ETDI HLRKL+H+NI++
Sbjct: 152 EDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIK 211
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
F+GVC++ +CIIMEFC YGPL + L P +++ W+K IA GM YLH+ KIIHR
Sbjct: 212 FKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHR 271
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLKSPN+L++ N V K+SDFGTSREW+ S MSF GTVAWMAPEVIR+EPCSE+VD+WS
Sbjct: 272 DLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWS 331
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
+GVVLWE+LT EIPYK +++ AI+WGVG ++ L VP++CPE KLL+ CW PRNRP
Sbjct: 332 YGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRP 391
Query: 247 PFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVR 306
F+ IL+HLDIAG E R ++ TQ +W++E+ + +KEI + Q L R
Sbjct: 392 SFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRR 451
Query: 307 REELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKAL 355
E R A+D R++YE +L + N+L+ E+ QL++KEK + ERE+ L
Sbjct: 452 TAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKL 500
>UniRef50_UPI00015B628A Cluster: PREDICTED: similar to LD14856p;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
LD14856p - Nasonia vitripennis
Length = 936
Score = 429 bits (1056), Expect = e-118
Identities = 196/347 (56%), Positives = 251/347 (72%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVR 66
+DWE+PFE I+++ +LGSGAQG V+SG L+ E+VAVKK+RE ETDI HLRKLNH NIV+
Sbjct: 124 DDWEIPFEYISELHWLGSGAQGAVFSGKLKKEIVAVKKVREPRETDIRHLRKLNHPNIVQ 183
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
F+GVC++ YCIIMEFC GPLYD L +G P ++ W+K IA GM YLH+ KIIHR
Sbjct: 184 FKGVCTQAPCYCIIMEFCPAGPLYDLLRAGEIIPPPRLSSWSKQIAAGMRYLHDHKIIHR 243
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLKSPNVL+ + K+SDFGTSREW+ +S M+F GTVAWMAPE+IR+EPCSE+VD+WS
Sbjct: 244 DLKSPNVLIGREDIVKISDFGTSREWNEKSTRMTFAGTVAWMAPEIIRNEPCSEKVDIWS 303
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
FGVVLWELL+ EIPYK +++ AI++GVG T+ LP+P +CPE K+L+ CW PRNRP
Sbjct: 304 FGVVLWELLSGEIPYKDVDSSAIMYGVGNNTLRLPIPKTCPEGFKILVELCWAAKPRNRP 363
Query: 247 PFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVR 306
FK I HL IA E R D + Q TW++EI MK+I + N L R
Sbjct: 364 SFKHIEMHLAIAAGELERTTQDDYFRAQQTWKEEIREHMKQIQSDNSSSPRFEADLIRRR 423
Query: 307 REELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREK 353
+ELR A+D R YE++L R N LYME+ AV LQLEQ+E+ + +RE+
Sbjct: 424 EDELRHAQDIREHYERKLERTNNLYMELSAVLLQLEQRERDVMKREQ 470
>UniRef50_UPI0000585FA7 Cluster: PREDICTED: similar to leucine
zipper bearing kinase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to leucine zipper
bearing kinase - Strongylocentrotus purpuratus
Length = 943
Score = 424 bits (1045), Expect = e-117
Identities = 196/360 (54%), Positives = 260/360 (72%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVRF 67
DWE+PFE+I ++ +LGSGAQG V+ G R E VAVKK+R+++ETDI HLRKLNH NIV
Sbjct: 138 DWEIPFENIRNLQWLGSGAQGAVFLGWYRTEPVAVKKVRDEKETDIKHLRKLNHPNIVTI 197
Query: 68 RGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
+GVC+ +CI+ME+C +G LY+ L G P+ +I W+K IAQGM YLH KIIHRD
Sbjct: 198 KGVCTLAPCFCILMEYCPFGQLYEVLRDGREIPPQLMIDWSKQIAQGMHYLHIHKIIHRD 257
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSF 187
LKSPNVLVA+N + K+SDFGTSREW+ +S MSF GTVAWMAPEVIR+EPCSE+VDVWSF
Sbjct: 258 LKSPNVLVANNDILKISDFGTSREWNEKSTKMSFAGTVAWMAPEVIRNEPCSEKVDVWSF 317
Query: 188 GVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPP 247
GVVLWELLT E+PYK +++ AI+WGVG+ ++ LP+P++CPE KLL+ QCW RNRP
Sbjct: 318 GVVLWELLTGEMPYKDVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPS 377
Query: 248 FKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVRR 307
F+ IL H+DIA +F + + Q WR+EI+ + +++ + + L R+
Sbjct: 378 FRQILMHIDIAAVDFLSTPQEAYFDKQVDWREEIKLQFEKMKSEGSSMCHIDEDLIKRRQ 437
Query: 308 EELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLRKTLK 367
+ELR A+D R YE++L RAN+LYME+ + LQLEQ+E+ L REK L +K+LK
Sbjct: 438 DELRHAQDIREHYERKLQRANDLYMELHSCLLQLEQRERELMRREKLLSEIEIKKKKSLK 497
>UniRef50_Q4S5N1 Cluster: Chromosome 9 SCAF14729, whole genome
shotgun sequence; n=2; Euteleostomi|Rep: Chromosome 9
SCAF14729, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 823
Score = 423 bits (1043), Expect = e-117
Identities = 207/415 (49%), Positives = 281/415 (67%), Gaps = 9/415 (2%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNI 64
+EE WEVPFE I+D+ ++GSGAQG V+ G GE VAVKK+R+ +ET+I HLRKL H NI
Sbjct: 14 NEESWEVPFEEISDLQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKETEIKHLRKLKHPNI 73
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKII 124
+ F+GVC++ YCI+ME+C G LY+ L +G TP ++ W+ IA GM YLH KII
Sbjct: 74 ITFKGVCTQAPCYCILMEYCAQGQLYEVLRAGRKITPSLLVDWSMGIAGGMNYLHLHKII 133
Query: 125 HRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDV 184
HRDLKSPN+L+ + + K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+
Sbjct: 134 HRDLKSPNMLITHDDLVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 193
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
WSFGVVLWE+LT EIPYK +++ AI+WGVG ++ LPVP SCP+ K+LL QCW+ PRN
Sbjct: 194 WSFGVVLWEMLTGEIPYKDVDSSAIIWGVGNNSLQLPVPESCPDGFKILLRQCWNCKPRN 253
Query: 245 RPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQS 304
RP F+ IL HLDIA A+ + + +QA WR+E++ ++I + ++L +
Sbjct: 254 RPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKRHFEKIKSEGTCLHRLDEELIN 313
Query: 305 VRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLRK 364
RREELR A D R YE++L RAN LYME+ AV LQLE KEK L RE++L GL
Sbjct: 314 RRREELRHALDIREHYERKLERANNLYMELSAVMLQLELKEKELQRREQSLDKKYPGL-- 371
Query: 365 TLKYYQRQNSSSSDGKSPLEVITEVPRR---RKRPE---AHVIVSYIEEDRQTVT 413
K++ + SSS++ L VP++ KRP+ + VI+ ++ +T
Sbjct: 372 -FKHHSSRQSSSTNTMDKLIKKRNVPQKLPSGKRPDLLKSEVIIPKMDSSVMQIT 425
>UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase
kinase 12; n=22; Euteleostomi|Rep: Mitogen-activated
protein kinase kinase kinase 12 - Homo sapiens (Human)
Length = 859
Score = 415 bits (1022), Expect = e-114
Identities = 199/360 (55%), Positives = 258/360 (71%), Gaps = 2/360 (0%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
E+ WEVPFE I D+ ++GSGAQG V+ G GE VAVKK+R+ +ETDI HLRKL H NI+
Sbjct: 115 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNII 174
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCI+MEFC G LY+ L +G TP ++ W+ IA GM YLH KIIH
Sbjct: 175 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 234
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ + V K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 235 RDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 294
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP+SCP+ K+LL QCW+ PRNR
Sbjct: 295 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 354
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ IL HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 355 PSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMR 414
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRC-GLRK 364
RREELR A D R YE++L RAN LYME+ A+ LQLE KE+ L RE+AL+ RC GL K
Sbjct: 415 RREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER-RCPGLLK 473
>UniRef50_O43283 Cluster: Mitogen-activated protein kinase kinase
kinase 13; n=27; Eumetazoa|Rep: Mitogen-activated
protein kinase kinase kinase 13 - Homo sapiens (Human)
Length = 966
Score = 414 bits (1020), Expect = e-114
Identities = 190/351 (54%), Positives = 252/351 (71%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
++ WEVPFE I+++ +LGSGAQG V+ G R E VA+KK+RE+ ETDI HLRKL H NI+
Sbjct: 158 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNII 217
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCIIME+C +G LY+ L +G TPR ++ W+ IA GM YLH KIIH
Sbjct: 218 AFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIH 277
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPNVLV K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 278 RDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 337
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP++CP+ K+L+ Q W PRNR
Sbjct: 338 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNR 397
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSV 305
P F+ L HLDIA A+ + + +QA WR+E++ ++I + ++L
Sbjct: 398 PSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRR 457
Query: 306 RREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALK 356
RREELR A D R YE++L RAN LYME+ A+ LQLE +EK L +RE+A++
Sbjct: 458 RREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVE 508
>UniRef50_Q4RX00 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 889
Score = 407 bits (1002), Expect = e-112
Identities = 206/420 (49%), Positives = 275/420 (65%), Gaps = 12/420 (2%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
+E WEVPFE I+D+ ++GSGAQG V+ G L G+ VAVKK+R +ETDI HLRKL H NI+
Sbjct: 163 DEAWEVPFEEISDLQWVGSGAQGAVFLGKLHGQEVAVKKVRNIKETDIKHLRKLKHPNII 222
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+G+C++ YCIIME+C G LY+ L +G P ++ WA IA GM YLH KIIH
Sbjct: 223 TFKGICTQAPCYCIIMEYCAQGQLYEVLRAGRKIQPCLLMDWAMGIAGGMNYLHLHKIIH 282
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSPN+L+ + K+SDFGTS+E ++S MSF GTVAWMAPEVIR+EP SE+VD+W
Sbjct: 283 RDLKSPNMLITYDDSVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 342
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWE+LT E+PYK +++ AI+WGVG ++ LPVP SCP+S KLLL QCW+ PRNR
Sbjct: 343 SFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLHLPVPESCPDSFKLLLRQCWNCKPRNR 402
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQAT--------WRKEIENEMKEIYTRNKEKFE 297
P F+ IL HLDIA A+ + + TQA+ WR E+ + ++I +
Sbjct: 403 PSFRQILLHLDIASADILSTPQETYFQTQASLFDYCFVEWRDEVRHHFEKIKSEGTCLHR 462
Query: 298 QAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKL 357
++L RREELR A D R YE++L RAN LYME+ A+ LQLE KEK L +RE++L
Sbjct: 463 LDEELIKRRREELRHALDIREHYERKLERANNLYMELNAIMLQLEIKEKELHKREQSLDK 522
Query: 358 CRCGLRKTLKYYQRQNSSSSDG-KSPLEVITEVPRRRKRPE---AHVIVSYIEEDRQTVT 413
G K Q +S+S + + ++P KRP+ + VI+ ++ VT
Sbjct: 523 KYQGCFKHPGSRQSASSNSMEKLMKKRNIPQKLPSHSKRPDLLKSEVILPKLDSSMTQVT 582
>UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG8789-PA, isoform A - Tribolium castaneum
Length = 832
Score = 361 bits (887), Expect = 3e-98
Identities = 173/383 (45%), Positives = 252/383 (65%), Gaps = 6/383 (1%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
++DWE+PFE ITD+ YLGSG QG V+SG L + VAVKK+ + +ETDI +L+KLNH NIV
Sbjct: 122 QDDWEIPFEQITDLTYLGSGGQGTVFSGMLNNQKVAVKKVYDIKETDIRNLKKLNHPNIV 181
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGMVYLHNRKII 124
+F+GVC++ IIME+C YGPL++ L + + T +++ WAK I GM YLH++KII
Sbjct: 182 KFKGVCTQLPCLSIIMEYCPYGPLFNLLKNQKNVVTINRVVSWAKQITSGMHYLHSQKII 241
Query: 125 HRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDV 184
HRDLKSPNVL+ + V K+SDFGTSR W S MSF GTVAWMAPE I+ CSE+VD+
Sbjct: 242 HRDLKSPNVLIGEEEVIKISDFGTSRTWSGVSEKMSFAGTVAWMAPEAIKELECSEKVDI 301
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
WSFGVVLWELLT E+PY +E AI++ VG + P+P +CP+ +L++ CW P+
Sbjct: 302 WSFGVVLWELLTCEVPYDGMEQSAIMYMVGCGKLRPPIPKTCPDGFRLIMEMCWKLNPKE 361
Query: 245 RPPFKIILAHLDIAGAE-FSRVLPDRFSVTQATWRKEIENEMKEIYTR-NKEKFE---QA 299
RP FK+IL HL IA E + ++F TQ +W++EI++++ + + K + E +
Sbjct: 362 RPSFKLILNHLQIASVEILGKYEDNQFFQTQESWKEEIKSQITQFKAQLQKHRIEFQLKE 421
Query: 300 QKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCR 359
++L R E++ RD R +Y+++L + ++LY+E+ AV Q+EQ + + K R
Sbjct: 422 EQLIKKRENEIKHVRDIRELYDRKLEKVHQLYLELSAVLQQVEQYNRQGGRKRDIQKNRR 481
Query: 360 CGLRKTLKYYQRQNSSSSDGKSP 382
K +R+++ S+ SP
Sbjct: 482 LINPFVRKMERRRSNHSTTPTSP 504
>UniRef50_O01700 Cluster: Putative uncharacterized protein dlk-1;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein dlk-1 - Caenorhabditis elegans
Length = 928
Score = 312 bits (765), Expect = 2e-83
Identities = 153/356 (42%), Positives = 223/356 (62%), Gaps = 6/356 (1%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
+E WE+PF++I+++ +LGSG+QG V+ G L VAVKK+ + +ET+I HLR L H NI+
Sbjct: 125 DELWEIPFDAISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHLRHLRHQNII 184
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F GVCS+ YCI+ME+C G L L S + T +W K+IA GM YLH K+IH
Sbjct: 185 EFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNKVIH 244
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDV 184
RDLKSPN+L++ K+ DFGTS + +S +MSF GTV+WMAPE+I+ +PC+E+VDV
Sbjct: 245 RDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDV 304
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
+SFGVVLWE+LT+E PY + AI++GVGT + LP+P P+ L LL+ QC + RN
Sbjct: 305 YSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRN 364
Query: 245 RPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIE-NEMKEIYTRN----KEKFEQA 299
RP F I H +I E + + + + ++R+ + + TR+ K F
Sbjct: 365 RPSFSHIRQHWEIFKPELFEMTEEEWQLAWDSYREFAKCIQYPSTVTRDHGGPKSAFAME 424
Query: 300 QKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKAL 355
+++Q R E+L +D R +YE +L R N++Y ++ +L+ KE L E EK L
Sbjct: 425 EEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWEKDL 480
>UniRef50_UPI0001555434 Cluster: PREDICTED: similar to
mitogen-activated protein kinase kinase kinase 12; n=1;
Ornithorhynchus anatinus|Rep: PREDICTED: similar to
mitogen-activated protein kinase kinase kinase 12 -
Ornithorhynchus anatinus
Length = 642
Score = 305 bits (749), Expect = 2e-81
Identities = 141/272 (51%), Positives = 183/272 (67%), Gaps = 5/272 (1%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIV 65
E WEVPFE I D+ ++GSGAQG V+ G GE VAVKK+R+ +ETDI HLR+L H NI+
Sbjct: 149 EAPWEVPFEEIRDLQWVGSGAQGAVFLGRFHGEDVAVKKVRDLKETDIKHLRRLKHPNII 208
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
F+GVC++ YCI+MEFC G L++ L +G TP ++ W+ IA GM YLH KIIH
Sbjct: 209 TFKGVCTQAPCYCILMEFCAQGQLFEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 268
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
RDLKSP V ++S G + S + G MAPEVIR+EP SE+VD+W
Sbjct: 269 RDLKSPKY-----KVIRLSQMGLTAWLSGRSPGLGVRGXXXXMAPEVIRNEPVSEKVDIW 323
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFGVVLWELLT EIPYK +++ AI+WGVG+ ++ LPVP+SCP+ K+LL QCW+ PRNR
Sbjct: 324 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 383
Query: 246 PPFKIILAHLDIAGAEFSRVLPDRFSVTQATW 277
P F+ IL HLDIA A+ + + +Q W
Sbjct: 384 PSFRQILLHLDIASADVLSTPQETYFKSQVGW 415
>UniRef50_Q16584 Cluster: Mitogen-activated protein kinase kinase
kinase 11; n=15; Mammalia|Rep: Mitogen-activated protein
kinase kinase kinase 11 - Homo sapiens (Human)
Length = 847
Score = 225 bits (551), Expect = 1e-57
Identities = 131/359 (36%), Positives = 195/359 (54%), Gaps = 26/359 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 123 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 182
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 241
Query: 128 LKSPNVLV-----ADNL---VAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ +D++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 242 LKSNNILLLQPIESDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 300
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CPE L+ CW
Sbjct: 301 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ P RP F IL L+ A+ R +P D F Q W++EI+ E+ + KE +
Sbjct: 361 QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR 420
Query: 299 AQKLQSVRREELRLARDTRLIYEQQLSRANELY-MEVCAVRLQLEQKEKHLDEREKALK 356
++L RE+ A R E++ E+ + Q++++ H+ R K
Sbjct: 421 EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFK 479
>UniRef50_Q02779 Cluster: Mitogen-activated protein kinase kinase
kinase 10; n=21; Euteleostomi|Rep: Mitogen-activated
protein kinase kinase kinase 10 - Homo sapiens (Human)
Length = 954
Score = 223 bits (545), Expect = 8e-57
Identities = 142/378 (37%), Positives = 199/378 (52%), Gaps = 43/378 (11%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD--------IMHLR---K 58
E+PF + +G G G VY RGE VAVK R E D R
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RG C + C++ME+ + G L L +G P ++ WA +A+GM YL
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
Query: 119 HNRK---IIHRDLKSPNVLVAD-----NL---VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN IIHRDLKS N+L+ + NL V K++DFG +REW +++ MS GT AW
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW-HKTTKMSAAGTYAW 269
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++CP
Sbjct: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLP-DRFSVTQATWRKEIENEMK 286
E LL +CWD P RP F IL L++ +P + F Q W+ EI++
Sbjct: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
Query: 287 EIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
++ T+ KE L+S E LR A++ R E+QL R + +L ++E
Sbjct: 390 DLRTKEKE-------LRSREEELLRAAQEQR-FQEEQLRRREQ----------ELAEREM 431
Query: 347 HLDEREKALKLCRCGLRK 364
+ ERE L +C+ K
Sbjct: 432 DIVERELHLLMCQLSQEK 449
>UniRef50_UPI0000F1F986 Cluster: PREDICTED: similar to mixed lineage
kinase 4 (KIAA1804); n=1; Danio rerio|Rep: PREDICTED:
similar to mixed lineage kinase 4 (KIAA1804) - Danio
rerio
Length = 976
Score = 219 bits (534), Expect = 2e-55
Identities = 134/381 (35%), Positives = 201/381 (52%), Gaps = 34/381 (8%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMH-----------LRKL 59
+PF + +G G G VY G + + VAVK R+ + DI L
Sbjct: 120 IPFSELVLQEIIGVGGFGKVYRGTWKVQEVAVKAARQDPDEDIKATADSVKQEAKLFSML 179
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLH 119
H NI++ GVC E N C++ME+ + G L L +G P ++ WA IA+GM YLH
Sbjct: 180 QHPNIIKLEGVCLEEPNLCLVMEYARGGTLNRAL-TGRRIPPHILVNWAVQIARGMQYLH 238
Query: 120 NRK---IIHRDLKSPNVLVADNL--------VAKVSDFGTSREWDNESAVMSFTGTVAWM 168
IIHRDLKS N+L+ + + K++DFG +REW +++ MS GT +WM
Sbjct: 239 EEAVVPIIHRDLKSSNILLLEKIENDDIGRKTLKITDFGLAREW-HKTTKMSAAGTYSWM 297
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
APEVI+ S+ DVWS+GV+LWELLT EIPY+ ++ A+ +GV + LP+P++CPE
Sbjct: 298 APEVIKSSLFSKGSDVWSYGVLLWELLTGEIPYRGIDGLAVAYGVAVNKLTLPIPSTCPE 357
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVTQATWRKEIENEMKE 287
L+ +CW++ P RP F IL L I A + + D F Q WR EI+ E
Sbjct: 358 PFAKLMEECWEQDPHIRPSFAAILEQLTAIEEAVMATMPQDSFHSMQEDWRVEIQEMFDE 417
Query: 288 IYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLE 342
+ T+ KE + ++ LQ EEL R+ +L E+++ N L E+ + Q
Sbjct: 418 LRTKEKELRSREEELTRAALQQKSHEELLKRREQQLA-EREI---NVLERELNILIFQQN 473
Query: 343 QKEKHLDEREKALKLCRCGLR 363
+ + ++ +R+ K R L+
Sbjct: 474 KDKPNVKKRKGKFKRSRLKLK 494
>UniRef50_UPI00015535B8 Cluster: PREDICTED: similar to mixed lineage
kinase MLK1; n=1; Mus musculus|Rep: PREDICTED: similar
to mixed lineage kinase MLK1 - Mus musculus
Length = 1164
Score = 216 bits (528), Expect = 9e-55
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 166 EIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 225
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 226 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 284
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 285 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 343
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 344 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 403
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 404 EPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFD 463
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 464 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 519
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 520 CQEKPRVKKRKGKFRKSRLKLK 541
>UniRef50_P80192 Cluster: Mitogen-activated protein kinase kinase
kinase 9; n=26; Coelomata|Rep: Mitogen-activated protein
kinase kinase kinase 9 - Homo sapiens (Human)
Length = 1104
Score = 215 bits (526), Expect = 2e-54
Identities = 138/382 (36%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 256
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + K++DFG +REW + + MS GT AW
Sbjct: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAW 315
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 316 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 375
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 376 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFD 435
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 436 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 491
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 492 CQEKPRVKKRKGKFRKSRLKLK 513
>UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 492
Score = 215 bits (524), Expect = 3e-54
Identities = 133/367 (36%), Positives = 195/367 (53%), Gaps = 24/367 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMH----LRK------- 58
E+PF +I + +G GA G VY G R E VAVK R D ++K
Sbjct: 69 EIPFRNIELIDVIGVGAFGKVYRGIWRDEEVAVKVARTDNYEDFTQTLDSVKKEARIFSM 128
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H NIV GV E N C+++E+ + G L L S + P ++ WA IAQGM Y
Sbjct: 129 LRHQNIVGLLGVSLEQPNLCLVLEYARGGALSRALSSYNRNIPPSVLLNWAIQIAQGMFY 188
Query: 118 LHNRK---IIHRDLKSPNVLV------AD-NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
LH+ I+HRDLKS N+L+ +D N + K++DFG +RE N + MS GT AW
Sbjct: 189 LHSEAPVTIVHRDLKSGNILLHYKINESDFNNILKITDFGLAREIANTTR-MSAAGTYAW 247
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S DVWS+GVVLWELLT ++PYK +E A+ +GV ++ LP+P +CP
Sbjct: 248 MAPEVIRTNTFSFASDVWSYGVVLWELLTGQVPYKDVEALAVAYGVAMNSLTLPIPTTCP 307
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E K L+ CW++ P RP FK +L L +I+ + + F Q W+ EIE
Sbjct: 308 EVFKNLMADCWNQDPHKRPTFKAVLEALEEISDSALMETQQESFQSMQDGWQTEIEQIFN 367
Query: 287 EIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
E+ + +E + +L+ ++ + A R E+ +R L ++ +Q +++ K
Sbjct: 368 ELKLKERELSSREDELRKIQMVQESHADALRRREEELAAREMNLLGREISIIIQQQKQLK 427
Query: 347 HLDEREK 353
++ K
Sbjct: 428 PSPKKRK 434
>UniRef50_Q3U1V8 Cluster: Mitogen-activated protein kinase kinase
kinase 9; n=14; Euteleostomi|Rep: Mitogen-activated
protein kinase kinase kinase 9 - Mus musculus (Mouse)
Length = 1077
Score = 215 bits (524), Expect = 3e-54
Identities = 137/382 (35%), Positives = 204/382 (53%), Gaps = 34/382 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK------- 58
E+ F +T +G G G VY G+ VAVK R + DI ++R+
Sbjct: 131 EIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 190
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NI+ RGVC + N C++MEF + GPL L SG P ++ WA IA+GM YL
Sbjct: 191 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYL 249
Query: 119 HNRKI---IHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGTVAW 167
H+ I IHRDLKS N+L+ N + +++DFG +REW + + MS GT AW
Sbjct: 250 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAREW-HRTTKMSAAGTYAW 308
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVIR S+ DVWS+GV+LWELLT E+P++ ++ A+ +GV + LP+P++CP
Sbjct: 309 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 368
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E L+ CW+ P +RP F IL L I + F + D F Q W+ EI+
Sbjct: 369 EPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFD 428
Query: 287 EIYTRNKE--KFEQ---AQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQL 341
++ + KE +E+ LQ +EEL R+ L E+++ + L E+ + QL
Sbjct: 429 QLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELA-EREI---DILERELNIIIHQL 484
Query: 342 EQKEKHLDEREKALKLCRCGLR 363
Q++ + +R+ + R L+
Sbjct: 485 CQEKPRVKKRKGKFRKSRLKLK 506
>UniRef50_Q9NYL2 Cluster: Mitogen-activated protein kinase kinase
kinase MLT; n=41; Chordata|Rep: Mitogen-activated
protein kinase kinase kinase MLT - Homo sapiens (Human)
Length = 800
Score = 213 bits (519), Expect = 1e-53
Identities = 129/324 (39%), Positives = 188/324 (58%), Gaps = 19/324 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE-ETDIMHLRKLNHDNIVR 66
++ F+ + G G+ G VY + + VAVKKL + E E +I+ + L+H NI++
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSV--LSHRNIIQ 67
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNR--- 121
F GV E NY I+ E+ G LYD+++S S I+ WA D+A+GM YLH
Sbjct: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
K+IHRDLKS NV++A + V K+ DFG SR + N + MS GT WMAPEVI+ P SE
Sbjct: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D +S+GVVLWE+LT+E+P+K LE + W V + L +P+SCP S LL+QCW+
Sbjct: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVLPDR---FSVTQATWRKEIENEMKEIYTRNKEKFEQ 298
+ RP FK I++ L+ + S LPD+ F +A WR EIE ++ + K + +
Sbjct: 247 AKKRPSFKQIISILESMSNDTS--LPDKCNSFLHNKAEWRCEIEATLERL---KKLERDL 301
Query: 299 AQKLQSVRREELRLARDTRLIYEQ 322
+ K Q ++ E RL + + EQ
Sbjct: 302 SFKEQELKERERRLKMWEQKLTEQ 325
>UniRef50_Q95UN8 Cluster: Mitogen-activated protein kinase kinase
kinase; n=1; Drosophila melanogaster|Rep:
Mitogen-activated protein kinase kinase kinase -
Drosophila melanogaster (Fruit fly)
Length = 1161
Score = 211 bits (515), Expect = 3e-53
Identities = 139/386 (36%), Positives = 199/386 (51%), Gaps = 37/386 (9%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRK----------- 58
E+ + + +GSG V+ G GE VA+K + E D+ +R
Sbjct: 136 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWA 195
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H+NI RGVC + C++ME+ + G L L P ++ WA IA+GM YL
Sbjct: 196 LKHENIAALRGVCLNTK-LCLVMEYARGGSLNRIL--AGKIPPDVLVNWAIQIARGMNYL 252
Query: 119 HNR---KIIHRDLKSPNVLVADNL--------VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN IIHRDLKS NVL+ + + K++DFG +RE N MS GT AW
Sbjct: 253 HNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQR-MSAAGTYAW 311
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
M PEVI S+ DVWS+GV+LWEL+T E PYK + ++ +GV T+ LP+P +CP
Sbjct: 312 MPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCP 371
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVTQATWRKEIENEMK 286
E+ L+ CW P RP FK IL L+ IA ++F+ + F Q WRKEI +
Sbjct: 372 ETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLH 431
Query: 287 EIYTRNKE---KFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQ-LE 342
++ + KE K EQ ++Q+ +RE+ L + I EQ L + +E V LQ +
Sbjct: 432 DLREKEKELRNKEEQLLRVQNEQREKANLLK----IREQNLRERERVLIERELVMLQPVP 487
Query: 343 QKEKH-LDEREKALKL-CRCGLRKTL 366
K KH ++ K L++ G R T+
Sbjct: 488 SKRKHKKGKKNKPLQISLPTGFRHTI 513
>UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed lineage
kinase 2; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to mixed lineage kinase 2 -
Strongylocentrotus purpuratus
Length = 960
Score = 210 bits (512), Expect = 8e-53
Identities = 136/385 (35%), Positives = 199/385 (51%), Gaps = 32/385 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD------IMHLRK----- 58
E+ F I +G G G V+ G+ RGE VAVK + E D I ++R+
Sbjct: 117 EIDFNEIQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLF 176
Query: 59 --LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGM 115
L+H NI+ RG C + CI+ME+ + G L L + P ++ WA IA GM
Sbjct: 177 SLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMPPNVLVNWAYQIADGM 236
Query: 116 VYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDNESAVMSFTGT 164
YLH +IHRDLKS N+L+ N+ K++DFG +RE ++ MS GT
Sbjct: 237 NYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREM-YKTTRMSAAGT 295
Query: 165 VAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPN 224
AWMAPEVI+ S+ DVWSFG++LWELLT E+PYK ++T A+ +G+ + LP+P+
Sbjct: 296 YAWMAPEVIKSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPS 355
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRVLPDRFSVTQATWRKEIEN 283
+CPE +L CW+ P RP F I+ L DI+ + F D F + Q W++EI+
Sbjct: 356 TCPEIFSKMLLDCWNYDPHERPTFSEIMQQLKDISESPFINTPQDSFHIMQQDWKEEIQE 415
Query: 284 EMKEIYTRNKEKFEQAQKL-QSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLE 342
E+ + KE + +L Q+ +++L A R + L E+ V Q +
Sbjct: 416 MFDELRVKEKELRTREDELSQAEIQQKLHAALLKRREQDLAEREIELLERELNLVITQQQ 475
Query: 343 QKEKHLDERE----KALKLCRCGLR 363
Q EK + ++ KA KL R R
Sbjct: 476 QDEKPVPKKRHGKIKANKLRRSNKR 500
>UniRef50_Q4T6K1 Cluster: Chromosome undetermined SCAF8722, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF8722, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 905
Score = 209 bits (511), Expect = 1e-52
Identities = 144/428 (33%), Positives = 216/428 (50%), Gaps = 56/428 (13%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDI----MHLRK-------L 59
V F ++ +G G G VY G RGE+VAVK R+ + DI ++++ L
Sbjct: 116 VDFRELSLQEIIGVGGFGKVYRGTWRGELVAVKAARQDPDEDISVTAQNVKQEARLFSML 175
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLH 119
H NI+ +GVC + N C+IME+ GPL L +G P ++ WA IA+GM+YLH
Sbjct: 176 THPNIIALKGVCLQEPNLCLIMEYASGGPLSRAL-AGRRIPPHILVNWAVQIAKGMLYLH 234
Query: 120 NRKI---IHRDLKSPN-------VLVAD--------NLVAKVSDFGTSREWDNESAVMSF 161
+ I IHRDLKS N VL+A+ +L K++DFG +REW +++ MS
Sbjct: 235 SEAIVPVIHRDLKSNNNISAFNGVLLAEAIENECMEDLTLKITDFGLAREW-HKTTKMST 293
Query: 162 TGTVAWMAPEVIRHEPCSERVDVW-------------SFGVVLWELLTQEIPYKTLETHA 208
GT AWMAPEVI+ S+ DVW S+GV+LWELLT E PYK ++ A
Sbjct: 294 AGTYAWMAPEVIKSSTFSKGSDVWRPFLGEGLFAVCASYGVLLWELLTGEAPYKGIDGLA 353
Query: 209 ILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLP- 267
+ +GV + LP+P++CPE L+ +CWD+ P RP F IL L + +P
Sbjct: 354 VAYGVAVNKLTLPIPSTCPEPFAQLMAECWDQDPHRRPNFSSILTQLTALERQVKEEMPQ 413
Query: 268 DRFSVTQATWRKEIENEMKEIYTRNKE---KFEQAQK--LQSVRREELRLARDTRLIYEQ 322
D F Q W+ EI++ E+ + KE + E+ ++ L+ EE R+ +L +
Sbjct: 414 DSFHSLQEDWKLEIQDMFDELRAKEKELRCREEELKRAALEQKSHEEFLRQREQQLAQWE 473
Query: 323 QLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLRKTLKYYQRQNSSSSDGKSP 382
Q EL + + + L Q++ ++ +R+ L + K L+ + N SD
Sbjct: 474 QDVFERELSLLI--LHLNQNQEKPNVKKRKGTLSM----RAKLLETHSNNNGELSDDFEA 527
Query: 383 LEVITEVP 390
T P
Sbjct: 528 YRPSTPTP 535
>UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;
n=1; Nasonia vitripennis|Rep: PREDICTED: hypothetical
protein - Nasonia vitripennis
Length = 1195
Score = 209 bits (510), Expect = 1e-52
Identities = 125/356 (35%), Positives = 190/356 (53%), Gaps = 24/356 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR----EKEETDIMHLRK------- 58
E+ FE +T +G G G VY G + VAVK R E+ + ++R+
Sbjct: 146 EIDFEELTLEEVIGVGGFGKVYRGFWNKKEVAVKAARQDPDEEPSATLQNVRQEAKLFWL 205
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H+NIV+ GVC + N C++ME+ + G L L SG P ++ WA IA+GM YL
Sbjct: 206 LKHENIVQLEGVCLKMPNMCLVMEYARGGSLNRVL-SGRKIRPDVLVDWAIQIARGMDYL 264
Query: 119 HNR---KIIHRDLKSPNVLVADNL--------VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN+ +IHRDLKS NVL+++ + K++DFG +RE ++ MS GT AW
Sbjct: 265 HNKAPISLIHRDLKSSNVLLSEPIENDDFQYKTLKITDFGLAREV-YKTTRMSAAGTYAW 323
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVI+ S+ DVWS+GV+LWELLT E PYK ++ A+ +GV + LP+P++CP
Sbjct: 324 MAPEVIKKSTFSKASDVWSYGVLLWELLTGETPYKGIDALAVAYGVAVNKLTLPIPSTCP 383
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKE 287
+ + L+ CW RP F IL LD + F+ + F Q WR EIE +
Sbjct: 384 QPWRCLMEACWLSDSHQRPGFAEILVALDEVRSAFAATPHESFHTMQEDWRLEIEQVLHG 443
Query: 288 IYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQ 343
+ + KE + ++L + ++ ++ R ++ +R +L AV + +Q
Sbjct: 444 LRMKEKELRCREEELSKAQVQQRQVEESLRQREKELAAREIDLLERELAVMITQQQ 499
>UniRef50_Q5TCX8 Cluster: Mitogen-activated protein kinase kinase
kinase; n=10; Eutheria|Rep: Mitogen-activated protein
kinase kinase kinase - Homo sapiens (Human)
Length = 1036
Score = 208 bits (508), Expect = 2e-52
Identities = 133/395 (33%), Positives = 207/395 (52%), Gaps = 47/395 (11%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------L 59
V FE + +G+G G VY +G+ VAVK R+ E D +R+ L
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--------------FTPRQII 105
H NI+ RGVC + + C+++EF + G L L + + P ++
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 106 RWAKDIAQGMVYLHNRK---IIHRDLKSPNVLVAD--------NLVAKVSDFGTSREWDN 154
WA IA+GM+YLH I+HRDLKS N+L+ + N K++DFG +REW +
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-H 297
Query: 155 ESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG 214
+ MS GT AWMAPEVI+ S+ D+WS+GV+LWELLT E+PY+ ++ A+ +GV
Sbjct: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
Query: 215 TETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVT 273
+ LP+P++CPE L+ +CW + P RP F +IL L I GA + + + F
Sbjct: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
Query: 274 QATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARDTRLIYEQQLSRAN 328
Q W+ EI+ E+ T+ KE + ++ LQ +EEL R+ +L E+++ +
Sbjct: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLA-EREI---D 473
Query: 329 ELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
L E+ + QL Q++ + +R+ K R L+
Sbjct: 474 VLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLK 508
>UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to
mitogen-activated protein kinase kinase kinase 9; n=2;
Coelomata|Rep: PREDICTED: similar to mitogen-activated
protein kinase kinase kinase 9 - Apis mellifera
Length = 1102
Score = 208 bits (507), Expect = 3e-52
Identities = 128/377 (33%), Positives = 196/377 (51%), Gaps = 24/377 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR----EKEETDIMHLRK------- 58
E+ FE + +G G G VY G + VAVK R E+ + ++R+
Sbjct: 193 EIDFEELQLEEVIGVGGFGKVYRGFWQKHEVAVKAARQDPDEEPSVTLENVRQEAKLFWL 252
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H+NIV+ GVC + N C++ME+ + G L L SG P ++ WA IA+GM YL
Sbjct: 253 LKHENIVQLEGVCLKMPNMCLVMEYARGGSLNRVL-SGRKIRPDVLVDWAIQIARGMDYL 311
Query: 119 HNR---KIIHRDLKSPNVLVADNL--------VAKVSDFGTSREWDNESAVMSFTGTVAW 167
HN+ +IHRDLKS NVL+++ + K++DFG +RE ++ MS GT AW
Sbjct: 312 HNKAPISLIHRDLKSSNVLLSEPIENDDLQYKTLKITDFGLAREV-YKTTRMSAAGTYAW 370
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCP 227
MAPEVI+ S+ DVWS+GV+LWELLT E PYK ++ A+ +GV + LP+P++CP
Sbjct: 371 MAPEVIKKSTFSKASDVWSYGVLLWELLTGETPYKGIDALAVAYGVAVNKLTLPIPSTCP 430
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKE 287
+ + L+ CW +RP F IL LD + F+ + F Q WR EIE +
Sbjct: 431 QPWRFLMEACWASDSHSRPGFAEILVALDEVRSAFAATPHESFHTMQEDWRLEIEQVLHG 490
Query: 288 IYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKH 347
+ + KE + ++L + ++ + + R ++ +R +L V + +Q
Sbjct: 491 LRMKEKELRCREEELTKAQVQQRQHEENLRQREQELAAREIDLLERELTVMIIQQQNTPT 550
Query: 348 LDEREKALKLCRCGLRK 364
++R K R L K
Sbjct: 551 PNKRRGKFKKSRLKLNK 567
>UniRef50_UPI000065D0F4 Cluster: Mitogen-activated protein kinase
kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2)
(Protein kinase MST).; n=1; Takifugu rubripes|Rep:
Mitogen-activated protein kinase kinase kinase 10 (EC
2.7.11.25) (Mixed lineage kinase 2) (Protein kinase
MST). - Takifugu rubripes
Length = 1053
Score = 205 bits (500), Expect = 2e-51
Identities = 138/390 (35%), Positives = 195/390 (50%), Gaps = 46/390 (11%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRK----- 58
L E E+ F + +G+G G VY G R E VAVK R+ + DI +
Sbjct: 77 LGECPLEIDFLELHLEEVIGAGGFGKVYKGMWRNEEVAVKAARQDPDEDISATAESVRQE 136
Query: 59 ------LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIA 112
L H NI+ RGVC N C++ME+ + G L L +G P+ ++ WA IA
Sbjct: 137 ARLFWMLQHRNIIALRGVCLREPNLCLVMEYARGGALNRAL-AGKKVPPKVLVNWAVQIA 195
Query: 113 QGMVYLHNRK---IIHRDLKSPNVLVA--------------------DNLVAKVSDFGTS 149
GM YLHN+ IIHRDLKS N+ V+ + K++DFG +
Sbjct: 196 AGMDYLHNQAFVPIIHRDLKSSNIFVSASSPSSSSVLILEPLERLSLGSKTLKITDFGLA 255
Query: 150 REWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAI 209
REW +++ MS GT AWMAPEVI+ S+ DVWSFGV+LWELLT E+PY+ ++ A+
Sbjct: 256 REW-HQTTKMSAAGTYAWMAPEVIKLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAV 314
Query: 210 LWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAH-LDIAGAEFSRVLPD 268
+GV + LP+P++CPE LL +CW P +RP F IL L I + ++ +
Sbjct: 315 AYGVAMNKLTLPIPSTCPEPFAQLLEECWSPNPHSRPSFTSILRQLLAIEQSAMFQMPLE 374
Query: 269 RFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVRREELRLARDTRLI------YEQ 322
F Q WR EI+ E+ + K F+ K L L+ + +E+
Sbjct: 375 SFHSLQEDWRLEIQQMFDELRAKEKVTFQLPTKPCRCCWVNLILSSSPSSLLQELRSWEE 434
Query: 323 QLSRANELYMEVCAVRLQLEQKEKHLDERE 352
L+RA E E QL ++E+ L ERE
Sbjct: 435 ALARAAEEQRE---QEEQLRRREQELAERE 461
>UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep:
EDR1-like - Oryza sativa subsp. japonica (Rice)
Length = 564
Score = 203 bits (495), Expect = 9e-51
Identities = 109/264 (41%), Positives = 154/264 (58%), Gaps = 11/264 (4%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEETDIMHLR 57
++WE+ F+ + + SG G +Y G GE VA+K L+ E+ ++ +R
Sbjct: 276 DEWEINFDVLDIQEKVASGTYGDLYRGTYFGEDVAIKVLKSDRLNENMQEEFNEEVFIMR 335
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMV 116
K+ H NIVRF G C++ CI+ EF + G +YD+LH SF +++ A DI++GM
Sbjct: 336 KIRHKNIVRFLGACTKSPTLCIVTEFMKNGSVYDYLHKRKGSFKLPSLLKAAVDISKGMN 395
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHE 176
YLH KIIHRDLK+ N+L+ ++ + KV+DFG +R + + TGT WMAPEVI H+
Sbjct: 396 YLHQNKIIHRDLKTANLLMDEHELIKVADFGVARVKAESGIMTAETGTYRWMAPEVIEHK 455
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
P + DV+SFGVVLWELLT +IP++ L GV E + +P + L LLL
Sbjct: 456 PYDSKADVFSFGVVLWELLTGKIPHEFLTPLQAAIGVVQEGLRPVIPKATDPKLALLLES 515
Query: 237 CWDRVPRNRPPFKIILAHLD-IAG 259
CW + NRP F IL LD IAG
Sbjct: 516 CWQQNAVNRPDFVQILQKLDEIAG 539
>UniRef50_Q4H377 Cluster: Mitogen-activated protein kinase kinase;
n=1; Ciona intestinalis|Rep: Mitogen-activated protein
kinase kinase - Ciona intestinalis (Transparent sea
squirt)
Length = 1093
Score = 199 bits (485), Expect = 1e-49
Identities = 118/317 (37%), Positives = 169/317 (53%), Gaps = 26/317 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD----IMHLRK------- 58
E+ F + +G G G VY G VA+K + + D + ++R
Sbjct: 54 EIDFSELALQEIIGVGGFGKVYHGFWSDREVAIKAAKVDPDEDASITLENVRSEARLFSL 113
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L+H NI+ GVC + N CI++E+ Q G L L G P ++ WA IA+GM YL
Sbjct: 114 LSHKNILALVGVCLQQPNLCIVLEYAQGGALNRCL-VGRKLPPHVLVDWALQIAEGMQYL 172
Query: 119 HNRK---IIHRDLKSPNVLVAD---------NLVAKVSDFGTSREWDNESAVMSFTGTVA 166
H +IHRDLKS NVL+ + N K+SDFG +RE ++ MS GT A
Sbjct: 173 HYDAPVPLIHRDLKSSNVLIKEPIGDAEDILNKTMKISDFGLAREM-YKTTKMSAAGTYA 231
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
WMAPEVI+ S+ DVWS+G++LWELLT E PY+ ++ A+ +GV + LP+P++C
Sbjct: 232 WMAPEVIKSSTYSKSSDVWSYGILLWELLTGEQPYRGIDGLAVAYGVAVNKLTLPIPSTC 291
Query: 227 PESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGAEFSRVLPDRFSVTQATWRKEIENEM 285
P+ K LL +CW + RP FK+IL L IA + F+ V D F Q WR EI+
Sbjct: 292 PKEFKDLLERCWSSNSQMRPSFKMILTDLQTIAESNFTSVPDDSFQSMQDDWRMEIQAMF 351
Query: 286 KEIYTRNKEKFEQAQKL 302
++ + KE + + L
Sbjct: 352 DDLRAKEKELCSREEAL 368
>UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr4 scaffold_6, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 840
Score = 181 bits (441), Expect = 3e-44
Identities = 99/261 (37%), Positives = 144/261 (55%), Gaps = 13/261 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRK 58
+WE+P+E + +G G+ G VY + G VAVKK ++ + ++ + +
Sbjct: 560 EWEIPWEDLQIGERIGIGSYGEVYRADWNGTEVAVKKFLAQDFSGDALVQFRYEVEIMLR 619
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVY 117
L H N+V F G + N I+ EF G LY LH S ++ +R A D+A+GM Y
Sbjct: 620 LRHPNVVLFMGAVTRPPNLSILTEFLPRGSLYRLLHRSNIQLDEKRRLRMALDVAKGMNY 679
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LH I+HRDLKSPN+LV N V KV DFG SR + + S GT WMAPEV+R
Sbjct: 680 LHTSHPTIVHRDLKSPNLLVDKNWVVKVCDFGLSRLKHHTFLSSKSTAGTPEWMAPEVLR 739
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP +E+ DV+SFGV+LWEL T IP+ + ++ VG + L +P + ++
Sbjct: 740 NEPSNEKCDVYSFGVILWELATLRIPWSGMNPMQVVGAVGFQDRRLEIPEEVDPMVAQII 799
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
N CW+ PR RP F +++ L
Sbjct: 800 NDCWEVEPRKRPSFSQLMSRL 820
>UniRef50_Q0IPW2 Cluster: Os12g0163800 protein; n=7;
Magnoliophyta|Rep: Os12g0163800 protein - Oryza sativa
subsp. japonica (Rice)
Length = 597
Score = 179 bits (436), Expect = 1e-43
Identities = 105/279 (37%), Positives = 151/279 (54%), Gaps = 32/279 (11%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRK 58
+WE+ + + SG+ G +Y G GE VAVK LR + ++ LR+
Sbjct: 274 EWEIDKRLLKMGGMIASGSCGDLYHGTYLGEDVAVKILRSEHLNKNVWNEFTQEVYILRE 333
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ-IIRWAKDIAQGMVY 117
+ H N+VRF G C++ +CII E+ G LYDF+H + ++++A D+ +GM Y
Sbjct: 334 VQHTNVVRFIGACTKPPQFCIITEYMSGGSLYDFVHKQHNVLDLPTLLKFAVDVCRGMCY 393
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE------ 171
LH R IIHRDLKS N+L+ + V KV+DFG +R D + + TGT WMAPE
Sbjct: 394 LHQRGIIHRDLKSANLLMDKDHVVKVADFGVARFQDQGGNMTAETGTYRWMAPEHFFSPC 453
Query: 172 -------------VIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETI 218
VI H+P + DV+SF +VLWEL+T +IPY T+ + VG
Sbjct: 454 SLGERMNWDKEEIVINHQPYDNKADVFSFAIVLWELITSKIPYNTMT--PLQAAVGVRQG 511
Query: 219 LLP-VPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
L P +P + L L+ +CW+ +P NRPPF ILA L+
Sbjct: 512 LRPGLPENAHPQLLDLMRRCWEGIPSNRPPFSDILAELE 550
>UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:
Protein kinase - Medicago truncatula (Barrel medic)
Length = 1022
Score = 177 bits (432), Expect = 4e-43
Identities = 99/261 (37%), Positives = 145/261 (55%), Gaps = 13/261 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEETDIMHLRK 58
++++P+E IT +G G+ G VY G G VAVK+ E+ ++++ +R+
Sbjct: 731 EYDIPWEEITMGERIGLGSYGEVYRGEWHGTEVAVKRFLLQDISGESLEEFKSEVQIMRR 790
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H N+V F G + N I+ EF G LY +H R+ +R A D A+GM Y
Sbjct: 791 LRHPNVVLFMGAITRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNY 850
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LHN I+HRDLKSPN+LV N V KV DFG SR ++ + S GT WMAPEV+R
Sbjct: 851 LHNSTPVIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKYSTFLSSRSTAGTAEWMAPEVLR 910
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+E E+ DV+S+GV+LWEL T P+ + ++ VG + L +P+ ++ ++
Sbjct: 911 NELSDEKCDVFSYGVILWELFTMRQPWGGMNPMQVVGAVGFQHRRLDIPDDVDTAIANII 970
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
QCW P+ RP F I+A L
Sbjct: 971 RQCWQTDPKLRPTFAEIMALL 991
>UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1;
Dictyostelium discoideum AX4|Rep: Protein kinase, TKL
group - Dictyostelium discoideum AX4
Length = 916
Score = 176 bits (429), Expect = 9e-43
Identities = 95/256 (37%), Positives = 141/256 (55%), Gaps = 11/256 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET----------DIMHLR 57
D E+ F + LG G GVVY G RG VA+K+++ E+ ++ L
Sbjct: 654 DIEISFSELKISSKLGEGTFGVVYKGLWRGSSVAIKQIKINEDVNNQVLEEFRKELTILS 713
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIR-WAKDIAQGMV 116
+L H NIV C+ N C I E+ G LYD LHS Q+ + A IAQGM
Sbjct: 714 RLRHPNIVLLMAACTAPPNLCFITEYLPGGSLYDALHSKKIKMNMQLYKKLAIQIAQGMN 773
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHE 176
YLH +IHRD+KS N+L+ +++ K+ DFG S+ + + G+ WM+PE++ E
Sbjct: 774 YLHLSGVIHRDIKSLNLLLDEHMNVKICDFGLSKLKSKSTEMTKSIGSPIWMSPELLMGE 833
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
+E+VDV++FG++LWEL T E+PY L++ + V T+++ P+PN+ P L L+
Sbjct: 834 DYTEKVDVYAFGIILWELGTGELPYSGLDSVQLALAVTTKSLRPPIPNAWPYQLSHLIQA 893
Query: 237 CWDRVPRNRPPFKIIL 252
CW + P RP F IL
Sbjct: 894 CWHQDPLKRPSFTEIL 909
>UniRef50_UPI000155F437 Cluster: PREDICTED: similar to Mitogen
activated protein kinase kinase kinase 11; n=1; Equus
caballus|Rep: PREDICTED: similar to Mitogen activated
protein kinase kinase kinase 11 - Equus caballus
Length = 736
Score = 175 bits (426), Expect = 2e-42
Identities = 97/235 (41%), Positives = 138/235 (58%), Gaps = 24/235 (10%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETDIM----HLRK-------LNHDNIVRFRGV 70
+G G G VY G+ RGE+VAVK R+ + DI +R+ L H NI+ + V
Sbjct: 124 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAV 183
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK---IIHRD 127
C E N C++ME+ GPL L +G P ++ WA IA+GM YLH +IHRD
Sbjct: 184 CLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRD 242
Query: 128 LKSPNVLVA--------DNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
LKS N+L+ ++ K++DFG +REW +++ MS GT AWMAPEVI+ S
Sbjct: 243 LKSNNILLLQPIEGDDMEHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFS 301
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ DVWSFGV+LWELLT E+PY+ ++ A+ +GV + LP+P++C E L+
Sbjct: 302 KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCTEPFAQLM 356
>UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr17 scaffold_16, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 977
Score = 174 bits (423), Expect = 5e-42
Identities = 99/261 (37%), Positives = 144/261 (55%), Gaps = 13/261 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRK 58
D E+P++ I +G G+ G VY G+ G VAVKK +++ +++ +++
Sbjct: 680 DCEIPWDEIALGERIGLGSYGEVYRGDWHGTEVAVKKFLDQDISGESLDEFRSEVRIMKR 739
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H N+V F G + N I+ EF G LY +H R+ +R A D A+GM Y
Sbjct: 740 LRHPNVVLFMGAVTRVPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNY 799
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LHN I+HRDLKSPN+LV N V KV DFG SR + + S GT WMAPEV+R
Sbjct: 800 LHNCTPVIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHSTFLSSRSTAGTAEWMAPEVLR 859
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP E+ DV+SFGV+LWEL T + P+ + ++ VG + L +P+ + ++
Sbjct: 860 NEPSDEKCDVFSFGVILWELSTLQQPWGGMNPMQVVGAVGFQHRRLDIPDDMDPVVADII 919
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
+CW P+ RP F I+A L
Sbjct: 920 RRCWHTNPKMRPTFAEIMATL 940
>UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8;
Brassicaceae|Rep: MAP kinase, putative - Arabidopsis
thaliana (Mouse-ear cress)
Length = 992
Score = 173 bits (422), Expect = 6e-42
Identities = 100/259 (38%), Positives = 141/259 (54%), Gaps = 13/259 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKLN 60
E+ +E IT +G G+ G VY G+ G VAVKK +++ T ++ +R+L
Sbjct: 709 EILWEEITVAERIGLGSYGEVYRGDWHGTAVAVKKFIDQDITGEALEEFRSEVRMMRRLR 768
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLH 119
H NIV F G + N I+ EF G LY +H R+ +R A D A+GM YLH
Sbjct: 769 HPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERKRLRMALDAARGMNYLH 828
Query: 120 --NRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIRHE 176
N I+HRDLKSPN+LV N V KV DFG SR + + S GT WMAPEV+R+E
Sbjct: 829 SCNPVIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKVSTYLSSKSTAGTAEWMAPEVLRNE 888
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
P ++ DV+S+GV+LWEL T + P+ + ++ VG + L +P + ++ +
Sbjct: 889 PADKKCDVYSYGVILWELFTLQQPWGKMNPMQVVGAVGFQHRRLDIPEFVDPGIADIIRK 948
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW PR RP F I+ L
Sbjct: 949 CWQTDPRLRPSFGEIMDSL 967
>UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza
sativa|Rep: Os06g0232100 protein - Oryza sativa subsp.
japonica (Rice)
Length = 598
Score = 173 bits (420), Expect = 1e-41
Identities = 96/261 (36%), Positives = 145/261 (55%), Gaps = 13/261 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRK 58
++E+ +E IT +G G+ G VY G G VAVKK +++ T+ +++
Sbjct: 316 EFEIQWEEITLGERVGLGSFGEVYKGEWHGTEVAVKKFLQQDISSDALDEFRTEFQIMKR 375
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H N+V F G + N I+ EF G L+ +H R+ +R A D+A+GM Y
Sbjct: 376 LRHPNVVLFMGAVTRVPNLSIVTEFLPRGSLFRLIHRPNNQLDERRRLRMALDVARGMNY 435
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIR 174
LHN ++HRDLKSPN+LV N V KV DFG SR ++ + S GT WMAPEV+R
Sbjct: 436 LHNCSPVVVHRDLKSPNLLVDKNWVVKVCDFGLSRMKNSTFLSSRSTAGTAEWMAPEVLR 495
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP E+ DV+S+GV+LWEL T P++ + ++ VG + L +P ++ ++
Sbjct: 496 NEPSDEKCDVFSYGVILWELFTLLQPWEGMNPMQVVGAVGFQQRRLDIPAHVDPTIAEII 555
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
+CW P+ RP F I++ L
Sbjct: 556 RRCWQTDPKMRPSFSEIMSSL 576
>UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (indica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. indica
(Rice)
Length = 651
Score = 173 bits (420), Expect = 1e-41
Identities = 96/261 (36%), Positives = 145/261 (55%), Gaps = 13/261 (4%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRK 58
++E+ +E IT +G G+ G VY G G VAVKK +++ T+ +++
Sbjct: 369 EFEIQWEEITLGERVGLGSFGEVYKGEWHGTEVAVKKFLQQDISSDALDEFRTEFQIMKR 428
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H N+V F G + N I+ EF G L+ +H R+ +R A D+A+GM Y
Sbjct: 429 LRHPNVVLFMGAVTRVPNLSIVTEFLPRGSLFRLIHRPNNQLDERRRLRMALDVARGMNY 488
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIR 174
LHN ++HRDLKSPN+LV N V KV DFG SR ++ + S GT WMAPEV+R
Sbjct: 489 LHNCSPVVVHRDLKSPNLLVDKNWVVKVCDFGLSRMKNSTFLSSRSTAGTAEWMAPEVLR 548
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP E+ DV+S+GV+LWEL T P++ + ++ VG + L +P ++ ++
Sbjct: 549 NEPSDEKCDVFSYGVILWELFTLLQPWEGMNPMQVVGAVGFQQRRLDIPAHVDPTIAEII 608
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
+CW P+ RP F I++ L
Sbjct: 609 RRCWQTDPKMRPSFSEIMSSL 629
>UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza
sativa|Rep: H0723C07.13 protein - Oryza sativa (Rice)
Length = 541
Score = 172 bits (419), Expect = 1e-41
Identities = 97/250 (38%), Positives = 136/250 (54%), Gaps = 16/250 (6%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKEETD---------IMHL-----RKLNHDNIVRF 67
+ SG+ G +Y G G VAVK LR + D IM L R ++H+N+V+F
Sbjct: 267 IASGSSGDLYRGTYLGVDVAVKFLRSEHVNDSSKVEFLQEIMILNEVMSRSVDHENVVQF 326
Query: 68 RGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMVYLHNRKIIHR 126
G C++ Y I+ E+ G LYDFLH + ++ R A I++GM YLH IIHR
Sbjct: 327 YGACTKHRKYLIVTEYMPGGNLYDFLHKQNNTLELPVVLRIAIGISKGMDYLHQNNIIHR 386
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLK+ N+L+ V K++DFG SR + + TGT WMAPEVI H+P + DV+S
Sbjct: 387 DLKTANLLIGSGQVVKIADFGVSRLRSQGGEMTAETGTYRWMAPEVINHKPYDHKADVFS 446
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
F +VLWEL+T +IPY+ L GV + + + +P L L+ +CWD P RP
Sbjct: 447 FAIVLWELVTTKIPYENLTPLQAALGV-RQGMRMEIPPKVHPRLSKLIERCWDENPHVRP 505
Query: 247 PFKIILAHLD 256
F I L+
Sbjct: 506 LFSEITVELE 515
>UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core
eudicotyledons|Rep: CTR1-like protein kinase - Solanum
lycopersicum (Tomato) (Lycopersicon esculentum)
Length = 837
Score = 170 bits (414), Expect = 6e-41
Identities = 99/264 (37%), Positives = 143/264 (54%), Gaps = 15/264 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE---------TDIM 54
L ED+++P+E + +G+G+ G V+ + G VAVK L E++ ++
Sbjct: 549 LEIEDFDIPWEDLVLKERIGAGSFGTVHRADWNGSDVAVKILMEQDFHAERFKEFLREVA 608
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GAS--FTPRQIIRWAKDI 111
+++L H NIV F G ++ N I+ E+ G LY LH GA R+ + A D+
Sbjct: 609 IMKRLRHPNIVLFMGAVTQRPNLSIVTEYLSRGSLYRLLHKPGAREVLDERRRLSMAYDV 668
Query: 112 AQGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWM 168
A+GM YLH R I+HRDLKSPN+LV KV DFG SR N + S GT WM
Sbjct: 669 AKGMNYLHKRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKANTFLSSKSAAGTPEWM 728
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
APEV+R EP +E+ DV+SFGV+LWEL T + P+ L ++ VG + L +P
Sbjct: 729 APEVLRDEPSNEKSDVYSFGVILWELATLQQPWSNLNPAQVVAAVGFKGKRLDIPRDLTP 788
Query: 229 SLKLLLNQCWDRVPRNRPPFKIIL 252
+ ++ CW + P RP F I+
Sbjct: 789 QVASIIEACWAKEPWKRPSFAAIM 812
>UniRef50_A7R2R7 Cluster: Chromosome chr4 scaffold_443, whole genome
shotgun sequence; n=7; Magnoliophyta|Rep: Chromosome
chr4 scaffold_443, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 226
Score = 169 bits (411), Expect = 1e-40
Identities = 85/191 (44%), Positives = 113/191 (59%), Gaps = 1/191 (0%)
Query: 63 NIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNR 121
N+V+F G C+ N CII EF G +YDFLH +F +++ A D+A+GM YLH
Sbjct: 1 NVVQFIGACTRPPNLCIITEFMSRGSVYDFLHKQRGAFKLPSLLKVAIDVAKGMNYLHEN 60
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
IIHRDLK+ N+L+ +N V KV+DFG +R + + TGT WMAPEVI H P + +
Sbjct: 61 NIIHRDLKTANLLMDENDVVKVADFGVARVQTQSGVMTAETGTYRWMAPEVIEHRPYNHK 120
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DV+SFG+VLWELLT E+PY L GV + + VP + LL +CW +
Sbjct: 121 ADVFSFGIVLWELLTGELPYSFLTPLQAAVGVVQKGLRPTVPKHTHPKIAGLLERCWWQD 180
Query: 242 PRNRPPFKIIL 252
P RP F IL
Sbjct: 181 PTLRPDFSTIL 191
>UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 793
Score = 169 bits (410), Expect = 2e-40
Identities = 93/255 (36%), Positives = 138/255 (54%), Gaps = 12/255 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGE-MVAVKKLREKE---------ETDIMHLRK 58
W V E + + +G GA VY G + + VA+KKL+ + + ++ L
Sbjct: 201 WRVNHEDLEEKQQIGEGASSTVYKGFFKHDKQVAIKKLKYHKLKGGKLRVFQREVSILAS 260
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
H +V F G ++ +CI+ E+ G LY L + + + A DIA+GM YL
Sbjct: 261 AEHPCLVHFVGA-TDTAPFCIVTEWINGGSLYALLRTKKPISASKKTSIAFDIARGMNYL 319
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
H+R IIHRDLKSPNVL+ DN AK+ DFG SR D+ + GT WMAPE++ ++
Sbjct: 320 HSRHIIHRDLKSPNVLLDDNGRAKICDFGYSRVADDTDVMTKNVGTPHWMAPELLDNQSS 379
Query: 179 -SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
+ +DV+S+G+VLWE+ Q +PY+ L++ I+ V + P+P + L+ QC
Sbjct: 380 YNHMIDVYSYGIVLWEITAQAVPYRDLDSPQIIAKVVSSDFRPPIPEGTHPDIVNLIKQC 439
Query: 238 WDRVPRNRPPFKIIL 252
WDR P RP F IL
Sbjct: 440 WDRDPNQRPTFSEIL 454
>UniRef50_Q9ZSD8 Cluster: Ethylene-inducible CTR1-like protein
kinase; n=2; eudicotyledons|Rep: Ethylene-inducible
CTR1-like protein kinase - Solanum lycopersicum (Tomato)
(Lycopersicon esculentum)
Length = 806
Score = 168 bits (409), Expect = 2e-40
Identities = 99/266 (37%), Positives = 142/266 (53%), Gaps = 15/266 (5%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE---------TD 52
L L E++ +P+ + M +G+G+ G V+ G+ G VAVK L E++ +
Sbjct: 518 LDLDVEEFNIPWNDLVLMEKIGAGSFGTVHRGDWHGSDVAVKILMEQDFHAERLKEFLRE 577
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GAS--FTPRQIIRWAK 109
+ +++L H NIV F G + N I+ E+ G LY LH GA R+ + A
Sbjct: 578 VAIMKRLRHPNIVLFMGAVIQPPNLSIVTEYLSRGSLYRLLHKPGAKKVLDERRPLCLAY 637
Query: 110 DIAQGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVA 166
D+A GM YLH R I+HRDLKSPN+LV K+ DFG SR N + + GT
Sbjct: 638 DVANGMNYLHKRNPPIVHRDLKSPNLLVDKKYTVKICDFGLSRFKANTFLSSKTAAGTPE 697
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
WMAPEVIR EP +E+ DV+SFGV+LWEL T + P+ L ++ VG L +P+
Sbjct: 698 WMAPEVIRDEPSNEKSDVYSFGVILWELATLQQPWNKLNPPQVIAAVGFNRKKLDIPSVL 757
Query: 227 PESLKLLLNQCWDRVPRNRPPFKIIL 252
+ +++ CW P RP F I+
Sbjct: 758 NPRVAIIIEACWANEPWKRPSFSTIM 783
>UniRef50_Q9LYI8 Cluster: MAP3K delta-1 protein kinase; n=3;
Arabidopsis thaliana|Rep: MAP3K delta-1 protein kinase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 886
Score = 168 bits (409), Expect = 2e-40
Identities = 91/243 (37%), Positives = 136/243 (55%), Gaps = 13/243 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRKL 59
WE+ +E + +G G+ G VY G VAVKK +++ +++I + +L
Sbjct: 642 WEIMWEDLQIGERIGIGSYGEVYRAEWNGTEVAVKKFLDQDFSGDALTQFKSEIEIMLRL 701
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYL 118
H N+V F G + N+ I+ EF G LY LH ++ +R A D+A+GM YL
Sbjct: 702 RHPNVVLFMGAVTRPPNFSILTEFLPRGSLYRLLHRPNHQLDEKRRMRMALDVAKGMNYL 761
Query: 119 HNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIRH 175
H ++HRDLKSPN+LV N V KV DFG SR + + S GT WMAPEV+R+
Sbjct: 762 HTSHPTVVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHHTYLSSKSTAGTPEWMAPEVLRN 821
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
EP +E+ DV+SFGV+LWEL T +P+K L ++ VG + L +P+ ++ ++
Sbjct: 822 EPANEKCDVYSFGVILWELATSRVPWKGLNPMQVVGAVGFQNRRLEIPDDIDLTVAQIIR 881
Query: 236 QCW 238
+CW
Sbjct: 882 ECW 884
>UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=5;
Magnoliophyta|Rep: Serine/threonine-protein kinase HT1 -
Arabidopsis thaliana (Mouse-ear cress)
Length = 390
Score = 168 bits (409), Expect = 2e-40
Identities = 104/308 (33%), Positives = 153/308 (49%), Gaps = 15/308 (4%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---EKEET----------DI 53
E+W + SGA +Y G + VAVK +R KEET ++
Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEV 136
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA--SFTPRQIIRWAKDI 111
L +L H NIV+F C + YCII E+ G L +L+ S + ++R A DI
Sbjct: 137 ALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDI 196
Query: 112 AQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
++GM YLH++ +IHRDLKS N+L+ D + KV+DFGTS GT WMAPE
Sbjct: 197 SRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPE 256
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+I+ +P + +VDV+SFG+VLWEL T +P++ + + V + P+P SC +L
Sbjct: 257 MIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALA 316
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTR 291
L+ +CW P RP F I+A L+ LP + +K I + +K T
Sbjct: 317 HLIKRCWSENPSKRPDFSNIVAVLEKYDECVKEGLPLTSHASLTKTKKAILDHLKGCVTS 376
Query: 292 NKEKFEQA 299
F +
Sbjct: 377 ISSPFSSS 384
>UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1;
n=10; Magnoliophyta|Rep: Serine/threonine-protein kinase
CTR1 - Arabidopsis thaliana (Mouse-ear cress)
Length = 821
Score = 168 bits (409), Expect = 2e-40
Identities = 99/266 (37%), Positives = 143/266 (53%), Gaps = 15/266 (5%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE---------TD 52
L L +D ++P+ + +G+G+ G V+ G VAVK L E++ +
Sbjct: 537 LGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLRE 596
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGA--SFTPRQIIRWAK 109
+ +++L H NIV F G ++ N I+ E+ G LY LH SGA R+ + A
Sbjct: 597 VAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAY 656
Query: 110 DIAQGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVA 166
D+A+GM YLHNR I+HRDLKSPN+LV KV DFG SR + + S GT
Sbjct: 657 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPE 716
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
WMAPEV+R EP +E+ DV+SFGV+LWEL T + P+ L ++ VG + L +P +
Sbjct: 717 WMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNL 776
Query: 227 PESLKLLLNQCWDRVPRNRPPFKIIL 252
+ ++ CW P RP F I+
Sbjct: 777 NPQVAAIIEGCWTNEPWKRPSFATIM 802
>UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein; n=2;
Dictyostelium discoideum|Rep: Leucine-rich
repeat-containing protein - Dictyostelium discoideum AX4
Length = 1288
Score = 168 bits (408), Expect = 3e-40
Identities = 116/351 (33%), Positives = 181/351 (51%), Gaps = 22/351 (6%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK---------KLREKEETDIMHLRK 58
+WEVP I +G G G V+ G+ RG VAVK KL ++ L K
Sbjct: 843 EWEVPLSEIAIGARIGRGGYGQVFRGSWRGTEVAVKMLFNDNVNLKLISDLRKEVDLLCK 902
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI-IRWAKDIAQGMVY 117
L H NIV F G C+E + CI+ E+ G L + L + + ++ D A+GM Y
Sbjct: 903 LRHPNIVLFMGACTEPSSPCIVTEYLSRGSLANILLDESIEMDWGLRLQLGFDCARGMTY 962
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRH 175
LH+R IIHRDLK+ N+LV D+ KV+DFG + + A + GT W+APEV+
Sbjct: 963 LHSRNPIIIHRDLKTDNLLVDDSWQVKVADFGLATVKSHTFA-KTMCGTTGWVAPEVLAE 1021
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
E +E+ DV+S+ +VLWELLT+ IPY T ++ + LP+P CP L+N
Sbjct: 1022 EGYTEKADVYSYAIVLWELLTRLIPYAGKNTMQVVRSIDRGE-RLPMPAWCPPKYAALMN 1080
Query: 236 QCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEK 295
+CW+ P +RP F IL ++ +EF + + S+ Q + K+ NK
Sbjct: 1081 RCWETDPTHRPSFPEILPIMEGMISEFQK--EKKESIAQGRPIPYVGPPEKD--PSNK-- 1134
Query: 296 FEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
+ Q + + +++L + +L+ EQQ+ + ++ ++ QLEQ++K
Sbjct: 1135 -QPPQNMATTIQQQLAQQQPQQLL-EQQILLQVQQQAQLQHLQQQLEQQQK 1183
>UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum
lycopersicum|Rep: TCTR2 protein - Solanum lycopersicum
(Tomato) (Lycopersicon esculentum)
Length = 982
Score = 167 bits (407), Expect = 4e-40
Identities = 95/254 (37%), Positives = 138/254 (54%), Gaps = 13/254 (5%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRK 58
D E+P+E + +G G+ G VY + G VAVKK +++ + ++ +R+
Sbjct: 693 DCEIPWEDLVIGERIGLGSYGEVYHADWNGTEVAVKKFLDQDFSGAALAEFKREVRIMRR 752
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
L H N+VRF G + + II EF G LY +H RQ I+ A D+A+GM
Sbjct: 753 LRHPNVVRFMGAITRPPHLSIITEFLPRGSLYRIIHRPHFQIDERQKIKMALDVAKGMDC 812
Query: 118 LH--NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIR 174
LH N I+HRDLKSPN+LV + KV DFG SR N + S GT WMAPEV+R
Sbjct: 813 LHTSNPTIVHRDLKSPNLLVDTDWNVKVCDFGLSRLKHNTFLSSKSTAGTPEWMAPEVLR 872
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP +E+ D++SFGV+LWEL T +P+ + ++ VG + L +P + ++
Sbjct: 873 NEPSNEKCDIYSFGVILWELATLRLPWSGMNPMQVVGAVGFQNKRLEIPKELDPIVARII 932
Query: 235 NQCWDRVPRNRPPF 248
+CW P RP F
Sbjct: 933 WECWQTDPNLRPSF 946
>UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole genome
shotgun sequence; n=2; core eudicotyledons|Rep:
Chromosome chr14 scaffold_54, whole genome shotgun
sequence - Vitis vinifera (Grape)
Length = 884
Score = 167 bits (405), Expect = 7e-40
Identities = 103/294 (35%), Positives = 151/294 (51%), Gaps = 18/294 (6%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETD 52
+F + E+P+E + +G G+ G VY G+ G VAVKK +++ + +
Sbjct: 589 MFEDVGECEIPWEDLVLGERIGLGSYGEVYHGDWNGTEVAVKKFLDQDFSGAALAEFKRE 648
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDI 111
+ +R+L H N+V F G + N II EF G LY LH ++ I+ A D+
Sbjct: 649 VRIMRRLRHPNVVLFMGAVTRPPNLSIITEFLPRGSLYRILHRPSCQIDEKRRIKMALDV 708
Query: 112 AQGMVYLHNR--KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWM 168
A+GM LH I+HRDLKSPN+LV N KV DFG SR N + S GT WM
Sbjct: 709 AKGMNCLHTSLPTIVHRDLKSPNLLVDKNWNVKVCDFGLSRLKHNTFLSSKSTAGTPEWM 768
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
APEV+R+E +E+ DV+SFG++LWEL T +P+ + ++ VG + L +P
Sbjct: 769 APEVLRNENSNEKCDVYSFGIILWELATLRLPWSGMNPMQVVGAVGFQNRRLDIPKEVDP 828
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSR-VLPDRFSVTQATWRKEI 281
+ ++ +CW P RP F A L +A R V+P T ++EI
Sbjct: 829 LVARIIWECWQTDPNLRPSF----AQLTVALKPLQRLVIPQHLDQQSLTLQQEI 878
>UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22;
Magnoliophyta|Rep: Protein kinase-like protein -
Arabidopsis thaliana (Mouse-ear cress)
Length = 412
Score = 165 bits (402), Expect = 2e-39
Identities = 91/270 (33%), Positives = 139/270 (51%), Gaps = 15/270 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE-------------ETDI 53
E+W + + GA G +Y G GE VA+K L + + ++
Sbjct: 122 EEWTIDLRKLHMGPAFAQGAFGKLYRGTYNGEDVAIKLLERSDSNPEKAQALEQQFQQEV 181
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDI 111
L L H NIVRF G C + +CI+ E+ + G + FL + + + A D+
Sbjct: 182 SMLAFLKHPNIVRFIGACIKPMVWCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVMQALDV 241
Query: 112 AQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
A+GM Y+H R IHRDLKS N+L++ + K++DFG +R + TGT WMAPE
Sbjct: 242 ARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPE 301
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+I+H P +++VDV+SFG+VLWEL+T +P++ + + V + VP C L
Sbjct: 302 MIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLG 361
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDIAGAE 261
++ +CWD P RP F I+ L+ A E
Sbjct: 362 EIMTRCWDADPEVRPCFAEIVNLLEAAETE 391
>UniRef50_A0CL90 Cluster: Chromosome undetermined scaffold_20, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_20,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 750
Score = 164 bits (399), Expect = 4e-39
Identities = 94/255 (36%), Positives = 139/255 (54%), Gaps = 16/255 (6%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET------------DIMHLRK 58
+ ++ I +G G+ G+V+ GN G+ VA+K +K+E ++ +
Sbjct: 472 INYQEIKQGPQIGKGSYGIVFKGNWLGQDVAIKSYCKKKEQQKHKQLMADFLKEVQVISN 531
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NIV + GVC + N+ +I E+ + G LYD +H + I+ +DI GM L
Sbjct: 532 LRHPNIVLYMGVCIKRHNFYLITEYMENGSLYDHIHKKKTKN-LNFIQIIEDITLGMNNL 590
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
H R+I+H DLKS NVL+ N K+ DFG SR ++ S GT WMAPE++R EP
Sbjct: 591 HGRRIMHCDLKSSNVLIDQNWNVKLCDFGLSRIKSKKTK--SMIGTPHWMAPEIMRGEPY 648
Query: 179 SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPN-SCPESLKLLLNQC 237
+E+ DV+SFG++LWE++T +IPY+ L I+ VG + +P S P L +L C
Sbjct: 649 TEKSDVYSFGMILWEIITGKIPYENLSITQIIGTVGWGHTQVEIPQFSNPPILAILAKDC 708
Query: 238 WDRVPRNRPPFKIIL 252
R P RP F IL
Sbjct: 709 LKREPSQRPTFAKIL 723
>UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677;
n=8; core eudicotyledons|Rep: Protein kinase, putative;
42705-46677 - Arabidopsis thaliana (Mouse-ear cress)
Length = 777
Score = 163 bits (396), Expect = 9e-39
Identities = 104/310 (33%), Positives = 161/310 (51%), Gaps = 21/310 (6%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD---------IMHLRK 58
++E+ ++ +T +G G+ G VY G G VAVK + ++E ++ + +++
Sbjct: 438 EYEILWDDLTIGEQIGQGSCGTVYHGLWFGSDVAVKLISKQEYSEEVIQSFRQEVSLMQR 497
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTP-RQIIRWAKDIAQGMVY 117
L H N++ F G + + CI+ EF G L+ L S R+ I A DIA+GM Y
Sbjct: 498 LRHPNVLLFMGAVTLPQGLCIVSEFLPRGSLFRLLQRNMSKLDWRRRINMALDIARGMNY 557
Query: 118 LH--NRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LH + IIHRDLKS N+LV NL KV+DFG SR + S G WMAPEV+R
Sbjct: 558 LHRCSPPIIHRDLKSSNLLVDKNLTVKVADFGLSRIKHHTYLTSKSGKGMPQWMAPEVLR 617
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+E E+ D++SFGVVLWEL T++IP++ L + ++ VG L +P L+
Sbjct: 618 NESADEKSDIYSFGVVLWELATEKIPWENLNSMQVIGAVGFMNQRLEIPKDIDPDWISLI 677
Query: 235 NQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKE 294
CW R + RP F+ ++ L R L ++++ R + ++ KE
Sbjct: 678 ESCWHRDAKLRPTFQELMERL--------RDLQRKYTIQFQATRAALSDKNKEREKERVG 729
Query: 295 KFEQAQKLQS 304
FEQ Q +++
Sbjct: 730 LFEQQQLVET 739
>UniRef50_Q0IZJ5 Cluster: Os09g0566500 protein; n=9;
Magnoliophyta|Rep: Os09g0566500 protein - Oryza sativa
subsp. japonica (Rice)
Length = 1229
Score = 163 bits (396), Expect = 9e-39
Identities = 96/255 (37%), Positives = 138/255 (54%), Gaps = 15/255 (5%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETD 52
L L+ +D +P+ + +G+G+ G V+ + G VAVK L E++ +
Sbjct: 476 LSLAVDDLIIPWNELILKEKIGAGSFGTVHRADWNGSDVAVKILMEQDFHPDRFREFMRE 535
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGAS--FTPRQIIRWAK 109
+ ++ L H NIV F G +E N I+ E+ G LY LH SGA R+ + A
Sbjct: 536 VAIMKSLRHPNIVLFMGAVTEPPNLSIVTEYLSRGSLYKLLHRSGAKEVLDERRRLNMAF 595
Query: 110 DIAQGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVA 166
D+A+GM YLH R I+HRDLKSPN+LV KV DFG SR N + S GT
Sbjct: 596 DVAKGMNYLHKRSPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKANTFLSSKSLAGTPE 655
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
WMAPEV+R EP +E+ DV+SFGV+LWEL+T + P+ L ++ VG + L +P
Sbjct: 656 WMAPEVLRDEPSNEKSDVYSFGVILWELMTMQQPWCNLNPAQVVAAVGFKGRRLDIPKDL 715
Query: 227 PESLKLLLNQCWDRV 241
+ L+ CW ++
Sbjct: 716 NPQVAALIESCWAKI 730
>UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core
eudicotyledons|Rep: Protein-tyrosine kinase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 525
Score = 163 bits (395), Expect = 1e-38
Identities = 79/213 (37%), Positives = 124/213 (58%), Gaps = 3/213 (1%)
Query: 47 EKEET-DIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQ 103
EK+ T ++ L +L H N+++F G + YC++ ++ G L FLH S ++
Sbjct: 252 EKQFTKEVTLLSRLTHPNVIKFVGAYKDPPVYCVLTQYLPEGSLRSFLHKPENRSLPLKK 311
Query: 104 IIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG 163
+I +A DIA+GM Y+H+R+IIHRDLK NVL+ + K++DFG + E + + G
Sbjct: 312 LIEFAIDIARGMEYIHSRRIIHRDLKPENVLIDEEFHLKIADFGIACEEEYCDMLADDPG 371
Query: 164 TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVP 223
T WMAPE+I+ +P + DV+SFG+VLWE++ IPY+ + + V + I +P
Sbjct: 372 TYRWMAPEMIKRKPHGRKADVYSFGLVLWEMVAGAIPYEDMNPIQAAFAVVHKNIRPAIP 431
Query: 224 NSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
CP ++K L+ QCW P RP F I+ L+
Sbjct: 432 GDCPVAMKALIEQCWSVAPDKRPEFWQIVKVLE 464
>UniRef50_Q01JS4 Cluster: OSIGBa0152L12.10 protein; n=4; Oryza
sativa|Rep: OSIGBa0152L12.10 protein - Oryza sativa
(Rice)
Length = 778
Score = 163 bits (395), Expect = 1e-38
Identities = 94/261 (36%), Positives = 142/261 (54%), Gaps = 16/261 (6%)
Query: 8 DW-EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE---------TDIMHLR 57
DW E+ ++ I +G+G+ G VY + G VAVK L +++ +I ++
Sbjct: 504 DWLEISWDEIELKERVGAGSFGTVYRADWHGSDVAVKVLTDQDVGEAQLKEFLREIAIMK 563
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH---SGASFTPRQIIRWAKDIAQG 114
++ H N+V F G ++ + I+ E+ G L+ ++ +G R+ +R A D+A+G
Sbjct: 564 RVRHPNVVLFMGAVTKCPHLSIVTEYLPRGSLFRLINKASAGEMLDLRRRLRMALDVAKG 623
Query: 115 MVYLH--NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPE 171
+ YLH N I+H DLK+PN+LV N KV DFG SR N + S GT WMAPE
Sbjct: 624 INYLHCLNPPIVHWDLKTPNMLVDKNWSVKVGDFGLSRFKANTFISSKSVAGTPEWMAPE 683
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+R EP +E+ DV+SFGV+LWEL+T + P+ L ++ V + LP+P L
Sbjct: 684 FLRGEPSNEKCDVYSFGVILWELMTMQQPWNGLSPAQVVGAVAFQNRRLPIPQETVPELA 743
Query: 232 LLLNQCWDRVPRNRPPFKIIL 252
L+ CWD PR RP F I+
Sbjct: 744 ALVESCWDDDPRQRPSFSSIV 764
>UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:
Protein kinase - Glycine max (Soybean)
Length = 462
Score = 162 bits (394), Expect = 2e-38
Identities = 84/259 (32%), Positives = 141/259 (54%), Gaps = 17/259 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET--------------- 51
E+W V + + GA +Y G + E VAVK + E+
Sbjct: 147 EEWNVDMSQLFFGLKFAHGAHSRLYHGVYKDEAVAVKIIMVPEDDGNGALASRLEKQFIR 206
Query: 52 DIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAK 109
++ L +L+H N+++F C + YCII E+ G L +LH + + +++I +A
Sbjct: 207 EVTLLSRLHHQNVIKFSAACRKPPVYCIITEYLAEGSLRAYLHKLEHQTISLQKLIAFAL 266
Query: 110 DIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMA 169
DIA+GM Y+H++ +IHRDLK N+L+ ++ K++DFG + E + + GT WMA
Sbjct: 267 DIARGMEYIHSQGVIHRDLKPENILINEDNHLKIADFGIACEEASCDLLADDPGTYRWMA 326
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
PE+I+ + ++VDV+SFG++LWE+LT IPY+ + + V + +P++CP +
Sbjct: 327 PEMIKRKSYGKKVDVYSFGLILWEMLTGTIPYEDMNPIQAAFAVVNKNSRPIIPSNCPPA 386
Query: 230 LKLLLNQCWDRVPRNRPPF 248
++ L+ QCW P RP F
Sbjct: 387 MRALIEQCWSLQPDKRPEF 405
>UniRef50_Q54U31 Cluster: SH2 domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: SH2 domain-containing
protein - Dictyostelium discoideum AX4
Length = 744
Score = 162 bits (394), Expect = 2e-38
Identities = 102/262 (38%), Positives = 144/262 (54%), Gaps = 16/262 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK-----KLREKEETDIMH----LRKLN 60
E+ E I +LG G+ G VY G RG+ VAVK KL E T H + K+
Sbjct: 271 EILPEEIDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIF 330
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVY 117
H N+V F G C++ I+ E CQ L LH+ + F+ + ++ AKD A GM +
Sbjct: 331 HPNVVLFLGACTQSGKMQIVTELCQTD-LEKLLHNDRTKKEFSLFRRMQMAKDAALGMNW 389
Query: 118 LHN-RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAV-MSFTGTVAWMAPEVIRH 175
LH +I+H DLK+ N+LV NL KV+DFG S+ + E + GT WMAPEV+
Sbjct: 390 LHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMG 449
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILW-GVGTETILLPVPNSCPESLKLLL 234
P +E+ DV+SFG++LWE+LT+E PY + + I + + E P+P SL+ L+
Sbjct: 450 NPYNEKADVYSFGIILWEILTKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLI 509
Query: 235 NQCWDRVPRNRPPFKIILAHLD 256
CWD P+NRP F IL L+
Sbjct: 510 QTCWDHNPQNRPSFSEILFRLN 531
>UniRef50_Q5CVX5 Cluster: Ser/Thr protein kinase with MORN repeats
at the N-terminus and a sterile alpha motif; n=2;
Cryptosporidium|Rep: Ser/Thr protein kinase with MORN
repeats at the N-terminus and a sterile alpha motif -
Cryptosporidium parvum Iowa II
Length = 659
Score = 162 bits (393), Expect = 2e-38
Identities = 86/257 (33%), Positives = 143/257 (55%), Gaps = 15/257 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSG--NLRGEMVAVKKLREKEE--------TDIMHL 56
+ +E+P + +G G G VY RG VAVK R +++ +++ +
Sbjct: 377 KSFEIPANELNLKCRIGEGGYGKVYKAIWTTRGITVAVKAFRRRDKHALAREFYSELTII 436
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGM 115
++ H N+ F GV YC++ E G L+D LH+ S+ T Q+++ ++DI GM
Sbjct: 437 SRIRHPNVTLFLGVVMS-PLYCLVTELVPNGSLFDLLHTKNSYLTSTQLLKISRDICCGM 495
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE---SAVMSFTGTVAWMAPEV 172
YLH ++H DLKS N+L++ N K+ DFG S ++ ++ GT WMAPE+
Sbjct: 496 AYLHENGVLHCDLKSSNILLSGNFNVKIGDFGLSTLMESPLETRKMLGCIGTHHWMAPEI 555
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKL 232
+R E ++ DV+SFG++LWE++T++IP++ L + I+ VG L +P + P ++K
Sbjct: 556 LRGEGFTKYADVYSFGIILWEMITKKIPHEDLNINHIVASVGYGHKELIIPENIPSTIKT 615
Query: 233 LLNQCWDRVPRNRPPFK 249
++ + W R RNRP FK
Sbjct: 616 VIKKTWSRNVRNRPNFK 632
>UniRef50_UPI00015B574B Cluster: PREDICTED: hypothetical protein;
n=1; Nasonia vitripennis|Rep: PREDICTED: hypothetical
protein - Nasonia vitripennis
Length = 533
Score = 161 bits (392), Expect = 3e-38
Identities = 90/252 (35%), Positives = 142/252 (56%), Gaps = 21/252 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ +E I +G G+ GVV+ G +G+ VA+K + + E ++ L ++ H NI
Sbjct: 13 EIDYEEIETEEIVGKGSFGVVWKGKWKGQSVAIKHINSEGEKKAFAVEVRQLSRVVHSNI 72
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA--SFTPRQIIRWAKDIAQGMVYLHN-- 120
V+ G C++ C++ME+ + G LY+ LHS S+T I WA A+G+ YLHN
Sbjct: 73 VKLYGACTKNP-VCLVMEYAEGGSLYNVLHSNLQLSYTAGHAISWALQCARGVAYLHNMQ 131
Query: 121 -RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
+ +IHRDLK PN+L ++ K+ DFGT+ D + + + G+ AWMAPEV
Sbjct: 132 PKPLIHRDLKPPNLLLISGGQTLKICDFGTA--CDLNTYMTNNKGSAAWMAPEVFEGSSY 189
Query: 179 SERVDVWSFGVVLWELLTQEIPYKTL--ETHAILWG--VGTETILLPVPNSCPESLKLLL 234
+E+ DV+S+GV+LWE L++ P+ + + I+W VG LL +CP ++ L+
Sbjct: 190 TEKCDVFSWGVILWETLSRRKPFDDIGGSAYRIMWAVHVGQRPSLL---ENCPPIIEDLI 246
Query: 235 NQCWDRVPRNRP 246
CW +VP RP
Sbjct: 247 VNCWSKVPDQRP 258
>UniRef50_Q9FGZ6 Cluster: Protein kinase; n=3; Arabidopsis
thaliana|Rep: Protein kinase - Arabidopsis thaliana
(Mouse-ear cress)
Length = 730
Score = 161 bits (392), Expect = 3e-38
Identities = 93/246 (37%), Positives = 136/246 (55%), Gaps = 13/246 (5%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD---------IMHLRK 58
D+E+ +E +T +G G+ G VY G G VAVK ++E ++ + +++
Sbjct: 483 DYEILWEDLTIGEQIGQGSCGTVYHGLWFGSDVAVKVFSKQEYSEEIITSFRQEVSLMKR 542
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTP-RQIIRWAKDIAQGMVY 117
L H N++ F G + + CI+ EF G L+ L S R+ I A DIA+GM Y
Sbjct: 543 LRHPNVLLFMGAVTSPQRLCIVTEFLPRGSLFRLLQRNTSKLDWRRRIHMASDIARGMNY 602
Query: 118 LHN--RKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LH+ IIHRDLKS N+LV N KV+DFG SR + + + GT WMAPEV+R
Sbjct: 603 LHHCTPPIIHRDLKSSNLLVDKNWTVKVADFGLSRIKHETYLTTKTGRGTPQWMAPEVLR 662
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+E E+ DV+SFGV+LWEL+T++IP+++L ++ VG L VP + L+
Sbjct: 663 NEAADEKSDVYSFGVILWELVTEKIPWESLNAMQVIGAVGFMNQRLEVPKNVDPQWISLM 722
Query: 235 NQCWDR 240
CW R
Sbjct: 723 ESCWHR 728
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 161 bits (392), Expect = 3e-38
Identities = 98/269 (36%), Positives = 144/269 (53%), Gaps = 16/269 (5%)
Query: 1 MLFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EET 51
M +S++ WE+P SI LG+G G V+ G G + VAVK L+E +E
Sbjct: 287 MFEISKDVWEIPRRSIKLERKLGNGQFGEVWEGTWNGTVRVAVKTLKEGAMDPTAFLQEA 346
Query: 52 DIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ--IIRWAK 109
+IM +KL H +V VCSEGE I+ E G L D+LH G R+ +I
Sbjct: 347 NIM--KKLRHPKLVALLAVCSEGEPIYIVTELMTNGCLLDYLHEGEGKQLREPELIDITA 404
Query: 110 DIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWM 168
+A GM YL +++ +HRDL + N+LV D KV+DFG SR ++E A + W
Sbjct: 405 QVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIEDEYIAKEGAKMPIKWT 464
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCP 227
APE I + + DVWSFG++++E++T+ +PY + +L V + +P P CP
Sbjct: 465 APEAINFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQV-SRGYRMPKPPECP 523
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ L + QCWD VP RP F+ + + LD
Sbjct: 524 DQLYDITKQCWDAVPEKRPTFEFLHSFLD 552
>UniRef50_A2DZZ0 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 938
Score = 161 bits (392), Expect = 3e-38
Identities = 91/271 (33%), Positives = 143/271 (52%), Gaps = 16/271 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREKE---------ETDIMH 55
E WE+ E + +GSG V+ G + G +VA+K+LR ++ + ++
Sbjct: 26 EQWEIEHEDLELQKRIGSGGFAEVFYGYRKSDGTVVAIKRLRNQQFDAKMLEMFKREVGI 85
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA---SFTPRQIIRWAKDIA 112
L L H I+ F G C++ +CI+ EF G L+ LH+ +P Q+ A +A
Sbjct: 86 LAGLRHFAILPFVGACTKPP-FCIVTEFMSGGSLFSRLHTKEITNRLSPTQLSIIALGVA 144
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAPE 171
GM +LH+ +++HRDLKS N+L+ K+ DFG +R N S M+ GT WMAPE
Sbjct: 145 YGMAFLHDNQMLHRDLKSLNILLDAENFPKICDFGMARAKSNSSEPMTGEIGTSQWMAPE 204
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
V+ + E+ DV+S+G++LWE+LT ++PY+ L I V + +P +CP +L+
Sbjct: 205 VLISQKYDEKADVYSYGIILWEMLTGDVPYRGLRDIQIAMSVVNQNNRPKIPKNCPHNLE 264
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDIAGAEF 262
+ CWD P RP F I+ L+ F
Sbjct: 265 KFIRICWDSDPSKRPDFNTIVRALESGAISF 295
>UniRef50_A0D9Q7 Cluster: Chromosome undetermined scaffold_42, whole
genome shotgun sequence; n=4; Alveolata|Rep: Chromosome
undetermined scaffold_42, whole genome shotgun sequence
- Paramecium tetraurelia
Length = 928
Score = 161 bits (392), Expect = 3e-38
Identities = 92/267 (34%), Positives = 148/267 (55%), Gaps = 21/267 (7%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-REKEETDIMH-------------L 56
+ F + +G G GVV+ G G+ VA+K + K + ++ + +
Sbjct: 642 IVFHELIIGQIIGEGGYGVVHKGKWLGQDVAIKSYGKRKSQGNLKYKLQMADFLKEVEVI 701
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ-IIRWAKDIAQGM 115
L H NIV + GVC +NY +I E+ + G L+D LH + ++ +++ +DIA GM
Sbjct: 702 SNLRHPNIVLYMGVCIRKQNYYLITEYLEEGSLFDHLHKKKTHIDQKALMQIVEDIALGM 761
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR---EWDNESAVMSFTGTVAWMAPEV 172
YLH RK++H DLKS NVL+ N K+ DFG S+ + D++ + GT WMAPE+
Sbjct: 762 NYLHGRKVMHCDLKSSNVLIDQNWNVKLCDFGLSKINKKIDHKVNKGARIGTPNWMAPEI 821
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILW--GVGTETILLPVPNSCPESL 230
+R EP E+ D++SFG++LWE++TQ+IPY+ L I+ G G + +++P NS P L
Sbjct: 822 MRGEPYQEKSDIYSFGMILWEIITQQIPYEGLSQTQIIGSVGYGQDQVIIP-SNSNPPIL 880
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLDI 257
+ +C + P RP F I+ + +
Sbjct: 881 LQIAKKCLKKNPNERPTFADIVNEIQM 907
>UniRef50_P18161 Cluster: Tyrosine-protein kinase 2; n=2;
Dictyostelium discoideum|Rep: Tyrosine-protein kinase 2
- Dictyostelium discoideum (Slime mold)
Length = 410
Score = 161 bits (392), Expect = 3e-38
Identities = 97/271 (35%), Positives = 147/271 (54%), Gaps = 21/271 (7%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEETDIM 54
L E ++ + I + +G GA V+ G +G VA+KKL+ E+ ++
Sbjct: 96 LGEREYIIDINDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKIIGDEEQFKERFIREVQ 155
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ------IIRWA 108
+L+K NH NIV F G C + CII E+ G LY+ LH+ S TP+ +++ A
Sbjct: 156 NLKKGNHQNIVMFIGACYKPA--CIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMA 213
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVA-- 166
D+A G+++LH+ I+HRDL S N+L+ + K+SDFG S E E ++ G +
Sbjct: 214 TDMALGLLHLHSITIVHRDLTSQNILLDELGNIKISDFGLSAEKSREGSMTMTNGGICNP 273
Query: 167 -WMAPEVIRH-EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPN 224
W PE+ ++ SE+VDV+ F +V+WE+LT EIP+ L+ V + P+P
Sbjct: 274 RWRPPELTKNLGHYSEKVDVYCFSLVVWEILTGEIPFSDLDGSQRSAQVAYAGLRPPIPE 333
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
C LKLLL QCW+ P +RPPF I+ L
Sbjct: 334 YCDPELKLLLTQCWEADPNDRPPFTYIVNKL 364
>UniRef50_Q5W6K6 Cluster: Kinase domain containing protein; n=2;
Oryza sativa|Rep: Kinase domain containing protein -
Oryza sativa subsp. japonica (Rice)
Length = 351
Score = 161 bits (390), Expect = 5e-38
Identities = 82/218 (37%), Positives = 123/218 (56%), Gaps = 4/218 (1%)
Query: 43 KKLREKEETDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFT-- 100
+++ + + ++ L +L H N+VR GVC E E Y II E + G L +LH ++
Sbjct: 83 REMEAQFDAEVSLLSRLRHPNVVRLVGVCREPEVYWIITELMRRGTLSAYLHGREPYSLP 142
Query: 101 PRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTS--REWDNESAV 158
P I+R A D+A+GM YLH R ++HRDLK N+++ KV+D GTS
Sbjct: 143 PETIVRLALDVARGMEYLHARGVVHRDLKPENLMLDGGGRVKVADLGTSCLEATCRGDKC 202
Query: 159 MSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETI 218
S GT WMAPE+I + C+ +VDV+SFG+VLWEL T +P++ L + + V
Sbjct: 203 SSKAGTFRWMAPEMIHDKRCNRKVDVYSFGLVLWELTTCLVPFQNLSPVQVAYSVCDRDA 262
Query: 219 LLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P+ SCP ++ L+ +CW P RP FK I++ L+
Sbjct: 263 RPPLSPSCPPAINSLIKRCWSTEPARRPEFKQIVSVLE 300
>UniRef50_Q54TA1 Cluster: E set domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: E set
domain-containing protein - Dictyostelium discoideum AX4
Length = 749
Score = 161 bits (390), Expect = 5e-38
Identities = 91/251 (36%), Positives = 142/251 (56%), Gaps = 16/251 (6%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKK--LREKEETDIMH--------LRKLNHDNIVRFRGVC 71
+G G+ V++G RG +VA+KK L +++ D ++ + +L H NI +F G C
Sbjct: 497 IGRGSCAEVFTGTWRGIIVAIKKAKLLNEDDEDFLNELAQEATIMSQLRHPNICQFLGTC 556
Query: 72 SEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVYLH--NRKIIHRDL 128
+ I+ME+ G LY LH + S ++ A DIA+GM YLH + +IHRDL
Sbjct: 557 NNPPEILIVMEYMPLGSLYRILHDPSISLDWPRMKSMALDIAKGMNYLHCCDPIVIHRDL 616
Query: 129 KSPNVLVADNLVAKVSDFGTSREWD---NESAVMSFTGTVAWMAPEVIRHEPCSERVDVW 185
KS N+LV ++ K+SDFG S + ++ M+ GT W APEV+R++P +E+ DV+
Sbjct: 617 KSHNLLVDEHYRVKISDFGLSTRFKKHLDKKTAMTPVGTPCWTAPEVLRNDPYTEKADVF 676
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SF +VLWE++T+E PY+ + T I+ VG + VP L+ +CW P+ R
Sbjct: 677 SFAIVLWEIVTREDPYQGMPTFQIVISVGQHKLRPIVPPQVSAPFTRLITECWSEDPQQR 736
Query: 246 PPFKIILAHLD 256
P F+ I+ L+
Sbjct: 737 PSFQEIVKRLE 747
>UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1;
Dictyostelium discoideum AX4|Rep: Protein kinase, TKL
group - Dictyostelium discoideum AX4
Length = 642
Score = 160 bits (388), Expect = 8e-38
Identities = 93/247 (37%), Positives = 134/247 (54%), Gaps = 13/247 (5%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLRE--------KE-ETDIMHLRKLNHDNIVRFRGVCS 72
+G G G VY G RG VAVKKL KE +I ++ L H N+++F G C
Sbjct: 380 IGKGNYGEVYLGTWRGSQVAVKKLPAHNINENILKEFHREINLMKNLRHPNVIQFLGSCL 439
Query: 73 EGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVYLHNRK--IIHRDLK 129
+ CI E+ G LY LH A +I+ D A+G++YLHN I+HRDLK
Sbjct: 440 IPPDICICTEYMPRGSLYSILHDQALQLQWSLLIKMMIDAAKGVIYLHNSTPVILHRDLK 499
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
S N+LV +N KV+DFG S + + A M+ GT W +PEV+R + +E+ DV+SFG+
Sbjct: 500 SHNLLVDENWKVKVADFGLSTI-EQQGATMTACGTPCWTSPEVLRSQRYTEKADVYSFGI 558
Query: 190 VLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFK 249
+LWE T++ PY + +++ VG E + PVP + P LL C + P +RP +
Sbjct: 559 ILWECATRQDPYFGIPPFQVIFAVGREGMRPPVPQNGPPKYIQLLIDCLNENPSHRPTME 618
Query: 250 IILAHLD 256
L L+
Sbjct: 619 QCLERLE 625
>UniRef50_P15056 Cluster: B-Raf proto-oncogene
serine/threonine-protein kinase; n=66; root|Rep: B-Raf
proto-oncogene serine/threonine-protein kinase - Homo
sapiens (Human)
Length = 766
Score = 159 bits (387), Expect = 1e-37
Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 22/281 (7%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+P IT +GSG+ G VY G G+ VAVK L T ++
Sbjct: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGV 504
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G ++ + I+ ++C+ LY LH F ++I A+ AQG
Sbjct: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W +G++ WMAPE
Sbjct: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 623
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+VL+EL+T ++PY + I++ VG + L V +
Sbjct: 624 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
+CP+++K L+ +C + RP F ILA +++ ++
Sbjct: 684 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 724
>UniRef50_UPI0000D56D6B Cluster: PREDICTED: similar to
Mitogen-activated protein kinase kinase kinase 7
(Transforming growth factor-beta-activated kinase 1)
(TGF-beta-activated kinase 1); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Mitogen-activated
protein kinase kinase kinase 7 (Transforming growth
factor-beta-activated kinase 1) (TGF-beta-activated
kinase 1) - Tribolium castaneum
Length = 511
Score = 159 bits (386), Expect = 1e-37
Identities = 87/265 (32%), Positives = 146/265 (55%), Gaps = 20/265 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD-----IMHLRKLNHDNI 64
E+ + I + +G G+ GVVY G R VAVK + + + D + L ++ H+NI
Sbjct: 17 EINYNEIQKLEAVGEGSFGVVYKGIWRDAFVAVKNIVSENDKDAFIVEVRQLSRVKHENI 76
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNRK 122
V+ G C++G N C++ME+ + G L++ LH + +T + W A+G+ YLH K
Sbjct: 77 VKLYGACTKGPNICLVMEYAEGGSLFNILHHAPNVHYTMANAMSWLYQCAKGVEYLHGMK 136
Query: 123 ---IIHRDLKSPNVLVAD-NLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
+IHRDLK PN+L+ + + K+ DFGT+ D + + + G+ AWMAPEV
Sbjct: 137 PKPLIHRDLKPPNLLLINGGTLLKICDFGTAT--DMTAIMTNNKGSAAWMAPEVFETSNY 194
Query: 179 SERVDVWSFGVVLWELLTQEIPYKTLE------THAILWGVGTETILLPVPNSCPESLKL 232
+E+ DV+S+G++LWE+L++ P+ ++ ILW + P+ CP ++
Sbjct: 195 TEKCDVFSWGIILWEVLSRLKPFFHIKESGYPSAFMILWAKHSGR-RPPLIRHCPPVIEK 253
Query: 233 LLNQCWDRVPRNRPPFKIILAHLDI 257
L+ QCWD+ RP K I+ +++
Sbjct: 254 LMTQCWDQEAAKRPSMKEIVKKMEV 278
>UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2;
Arabidopsis thaliana|Rep: Putative serine/threonine
kinase - Arabidopsis thaliana (Mouse-ear cress)
Length = 736
Score = 158 bits (384), Expect = 3e-37
Identities = 99/269 (36%), Positives = 148/269 (55%), Gaps = 21/269 (7%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK----------KLRE-KEETD 52
+++ E+ +E + +G G+ V+ G G VA+K L E K+E +
Sbjct: 456 VTDSSCEIRWEDLQLGEEVGRGSFAAVHRGVWNGSDVAIKVYFDGDYNAMTLTECKKEIN 515
Query: 53 IMHLRKLNHDNIVRFRG-VCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKD 110
IM +KL H N++ F G VC+E E IIME+ G L+ LH+ ++ +R A D
Sbjct: 516 IM--KKLRHPNVLLFMGAVCTE-EKSAIIMEYMPRGSLFKILHNTNQPLDKKRRLRMALD 572
Query: 111 IAQGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES--AVMSFTGTVA 166
+A+GM YLH R I+HRDLKS N+LV N KV DFG S+ W N + + S GT
Sbjct: 573 VARGMNYLHRRNPPIVHRDLKSSNLLVDKNWNVKVGDFGLSK-WKNATFLSTKSGKGTPQ 631
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
WMAPEV+R EP +E+ DV+SFGV+LWEL+T +P+ L + ++ VG L +P
Sbjct: 632 WMAPEVLRSEPSNEKCDVFSFGVILWELMTTLVPWDRLNSIQVVGVVGFMDRRLDLPEGL 691
Query: 227 PESLKLLLNQCWDRVPRNRPPFKIILAHL 255
+ ++ CW P RP F+ +++ +
Sbjct: 692 NPRIASIIQDCWQTDPAKRPSFEELISQM 720
>UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole genome
shotgun sequence; n=2; Vitis vinifera|Rep: Chromosome
chr2 scaffold_112, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 715
Score = 158 bits (384), Expect = 3e-37
Identities = 99/259 (38%), Positives = 137/259 (52%), Gaps = 17/259 (6%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK----------KLRE-KEETDI 53
S D E+ +E + +G G+ VY G G VA+K L++ K+E DI
Sbjct: 429 SVSDCEIQWEDLHFGEEIGRGSYAAVYHGIWNGSDVAIKVYFGNEYSEGTLQDYKKEIDI 488
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIA 112
M R+L H N++ F G E I+ E G L+ LH S R+ +R A D+A
Sbjct: 489 M--RRLRHPNVLLFMGAVYSQERLAIVTELLPRGSLFRVLHKSNQVLDIRRRLRMALDVA 546
Query: 113 QGMVYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMA 169
+GM YLH+R I+HRDLKS N+LV N KV DFG S+ + S GT WMA
Sbjct: 547 RGMNYLHHRNPPIVHRDLKSSNLLVDKNWNVKVGDFGLSKLKHTTFLTAKSGRGTPQWMA 606
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
PEV+R++P +E+ DV+SFGV+LWEL+TQ IP+ L + ++ VG L +P
Sbjct: 607 PEVLRNDPSNEKSDVFSFGVILWELMTQSIPWVHLNSLQVVGIVGFMDRRLDLPEGLDPR 666
Query: 230 LKLLLNQCWDRVPRNRPPF 248
+ L+ CW P RP F
Sbjct: 667 VSSLIQDCWKTNPEQRPSF 685
>UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Oryza
sativa (Rice)
Length = 903
Score = 158 bits (383), Expect = 3e-37
Identities = 91/260 (35%), Positives = 138/260 (53%), Gaps = 13/260 (5%)
Query: 2 LFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETD 52
+F + E+ +E + +G G+ G VY + G VAVKK +++ ++
Sbjct: 607 MFDDVSECEIHWEDLVIGERIGLGSYGEVYRADWNGTEVAVKKFLDQDFYGDALDEFRSE 666
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDI 111
+ +R+L H NIV F G + N I+ E+ G LY LH ++ I+ A D+
Sbjct: 667 VRIMRRLRHPNIVLFMGAVTRPPNLSIVSEYLPRGSLYKILHRPNCQIDEKRRIKMALDV 726
Query: 112 AQGMVYLHNR--KIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWM 168
A+GM LH I+HRDLKSPN+LV +N KV DFG SR + + S GT WM
Sbjct: 727 AKGMNCLHISVPTIVHRDLKSPNLLVDNNWNVKVCDFGLSRLKHSTFLSSKSTAGTPEWM 786
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
APEV+R+E +E+ DV+SFGV+LWEL T +P+ + ++ VG + L +P
Sbjct: 787 APEVLRNEQSNEKCDVYSFGVILWELATLRMPWSGMNPMQVVGAVGFQDKRLDIPKEIDP 846
Query: 229 SLKLLLNQCWDRVPRNRPPF 248
+ ++ +CW + P RP F
Sbjct: 847 LVARIIWECWQKDPNLRPSF 866
>UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Triticum
aestivum (Wheat)
Length = 959
Score = 158 bits (383), Expect = 3e-37
Identities = 90/259 (34%), Positives = 136/259 (52%), Gaps = 13/259 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRKLN 60
E+ +E + +G G+ G VY + G VAVKK ++E ++ +R+L
Sbjct: 674 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 733
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLH 119
H NIV F G + + I+ E+ G LY +H ++ I+ A D+A+GM LH
Sbjct: 734 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 793
Query: 120 NR--KIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIRHE 176
I+HRDLKSPN+LV DN KV DFG SR + + S GT WMAPEV+R+E
Sbjct: 794 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNE 853
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
+E+ D++SFGV+LWEL T P+ + ++ VG + L +P + ++
Sbjct: 854 QSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 913
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW + P RP F + ++L
Sbjct: 914 CWQKDPNLRPSFIQLTSYL 932
>UniRef50_UPI0000DB7E21 Cluster: PREDICTED: similar to
Mitogen-activated protein kinase kinase kinase 7
(Transforming growth factor-beta-activated kinase 1)
(TGF-beta-activated kinase 1); n=1; Apis mellifera|Rep:
PREDICTED: similar to Mitogen-activated protein kinase
kinase kinase 7 (Transforming growth
factor-beta-activated kinase 1) (TGF-beta-activated
kinase 1) - Apis mellifera
Length = 510
Score = 157 bits (382), Expect = 4e-37
Identities = 86/250 (34%), Positives = 140/250 (56%), Gaps = 17/250 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET-----DIMHLRKLNHDNI 64
E+ ++ I +G G+ GVV+ G +G+ VA+K + + E ++ L ++ H NI
Sbjct: 16 EINYDEIETEQVVGKGSFGVVWKGRWKGQYVAIKYINSEGEKKAFTIEVRQLSRVIHPNI 75
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNRK 122
V+ G C++ C++ME+ + G LY+ LH +T + WA A+G+ YLHN K
Sbjct: 76 VKLYGACTKNP-VCLVMEYAEGGSLYNVLHCNPQPQYTAGHAMSWALQCARGVAYLHNMK 134
Query: 123 ---IIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
+IHRDLK PN+L V K+ DFGT+ D + + + G+ AWMAPEV
Sbjct: 135 PKPLIHRDLKPPNLLLVMGGQTLKICDFGTA--CDLNTYMTNNKGSAAWMAPEVFEGSKY 192
Query: 179 SERVDVWSFGVVLWELLTQEIPYKTL--ETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
+E+ DV+S+GV+LWE+L+++ P+ + + I+W V P+ CP+ L+ L+ +
Sbjct: 193 TEKCDVFSWGVILWEILSRKKPFDEIGGSAYRIMWAVHIGQ-RPPLIEDCPKPLEDLMIR 251
Query: 237 CWDRVPRNRP 246
CW + P RP
Sbjct: 252 CWHKSPEERP 261
>UniRef50_P04049 Cluster: RAF proto-oncogene
serine/threonine-protein kinase; n=90; root|Rep: RAF
proto-oncogene serine/threonine-protein kinase - Homo
sapiens (Human)
Length = 648
Score = 157 bits (381), Expect = 6e-37
Identities = 97/269 (36%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + +GSG+ G VY G G+ VAVK L+ + T ++ LRK
Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 400
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++ +N I+ ++C+ LY LH F Q+I A+ AQGM YL
Sbjct: 401 RHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
H + IIHRD+KS N+ + + L K+ DFG W V TG+V WMAPEVIR
Sbjct: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVG---TETILLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG L + +CP+
Sbjct: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C +V RP F IL+ +++
Sbjct: 580 AMKRLVADCVKKVKEERPLFPQILSSIEL 608
>UniRef50_Q173R9 Cluster: Tak1; n=1; Aedes aegypti|Rep: Tak1 - Aedes
aegypti (Yellowfever mosquito)
Length = 436
Score = 157 bits (380), Expect = 8e-37
Identities = 82/249 (32%), Positives = 140/249 (56%), Gaps = 15/249 (6%)
Query: 20 MYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNIVRFRGVCSEG 74
M +G G+ G V + + VAVK + + + T++ L ++ H NI+ G C+
Sbjct: 1 MTVGKGSFGTVNKAKWQNKYVAVKYIEVEADRDAFITEVCQLSRVAHPNIIGLYGACTRR 60
Query: 75 ENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHNRK---IIHRDLK 129
C++ME+ G L+ LH +T + WA+ A+G+ YLH+ + +IHRDLK
Sbjct: 61 PTVCLVMEYADGGSLHSVLHCRPKPHYTAAHAMSWARQCAEGVAYLHDMRPKAMIHRDLK 120
Query: 130 SPNVLVADN-LVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFG 188
PN+L+ N V K+ DFGT D + + + G+ AWMAPEV +E+ DV+S+G
Sbjct: 121 PPNLLLVKNGTVLKICDFGTVT--DKSTRMTNNKGSAAWMAPEVFEGSTYTEKCDVFSWG 178
Query: 189 VVLWELLTQEIPYKTLET-HAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPP 247
++LWE++ +E P++ LE ++ILW V + P+ CP+ ++ L+ CW++ PR RP
Sbjct: 179 IILWEVIAREQPFENLENPYSILWKV-HQGCRPPLIVGCPKPIEQLMTSCWNQDPRKRPS 237
Query: 248 FKIILAHLD 256
+ ++ ++
Sbjct: 238 MQDVVDQMN 246
>UniRef50_A2FSF7 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 818
Score = 157 bits (380), Expect = 8e-37
Identities = 97/267 (36%), Positives = 139/267 (52%), Gaps = 12/267 (4%)
Query: 14 ESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKL-----REKEETDIMHLRKLNHDNIVR 66
E +T +GSG G V+ GN VA+KKL E+ ++I L+ +V
Sbjct: 24 EDLTFEKVIGSGGFGEVWIGNYIPSNTKVAIKKLFADELSEQTMSEISLHASLSQQFLVP 83
Query: 67 FRGVCSEGENYCIIMEFCQYGPLYDFLHSG---ASFTPRQIIRWAKDIAQGMVYLHNRKI 123
F G +E + CI+ ++ G LYD LH+ S +P + A IA GM Y+H+R I
Sbjct: 84 FIGYTNE-KPLCIVTQYISNGSLYDALHNQNPQVSLSPTDLTIIAFGIASGMAYIHSRNI 142
Query: 124 IHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVD 183
IHRDLK+ N+L+ L+ K+ DFGTS + A+ GT A MAPE+ R E + VD
Sbjct: 143 IHRDLKTLNILLDSQLLPKIIDFGTSSS-NKSRAINQDVGTAAIMAPELHRFEKYDQSVD 201
Query: 184 VWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
V+S+G++LWE+LT +IP+ E I++ V + +PN P L L+N CW P+
Sbjct: 202 VYSYGIILWEMLTHDIPFGDKEPVQIVYCVAQKGERPILPNDVPIPLMKLINSCWAEDPK 261
Query: 244 NRPPFKIILAHLDIAGAEFSRVLPDRF 270
RP F I A F +P F
Sbjct: 262 QRPAFSEICAKFLSGEVSFKGSVPQAF 288
>UniRef50_A0C299 Cluster: Chromosome undetermined scaffold_144,
whole genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_144,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 828
Score = 156 bits (379), Expect = 1e-36
Identities = 90/260 (34%), Positives = 134/260 (51%), Gaps = 14/260 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-----EKEETDIMH----LRKLN 60
++ F I + G GV+Y R +VAVK + E D + + L
Sbjct: 564 DIDFNDIMLEKQISEGGYGVIYRAKWRETVVAVKMFKIDGMNENHIRDFLSECHAMEALR 623
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLH 119
H NIV F G C++ N I++E+CQ G L+ + + T + A D A+G++YLH
Sbjct: 624 HPNIVMFLGACTKPPNLAIVLEYCQRGSLWQVIQNHDIHLTWEDRRKMALDAAKGVLYLH 683
Query: 120 --NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
N I+HRDLKS N+L+ + K++DFG +R N + S GT WMAPEVI +
Sbjct: 684 SFNPPILHRDLKSLNLLLDEAFRTKLADFGWTRTLSNY--MTSKIGTYQWMAPEVIAGQV 741
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
+E+ DV+SFG++LWE+ +E PY+ + + V +P PE L +C
Sbjct: 742 YTEKADVFSFGIILWEIAAREPPYRNITGLQVSLDVLNNDFRPTIPKKTPEVFTRLTKRC 801
Query: 238 WDRVPRNRPPFKIILAHLDI 257
WDR P RP FK I+ L++
Sbjct: 802 WDRDPEKRPSFKEIIKELEM 821
>UniRef50_Q9C547 Cluster: Protein kinase, putative; 12576-15979;
n=7; Magnoliophyta|Rep: Protein kinase, putative;
12576-15979 - Arabidopsis thaliana (Mouse-ear cress)
Length = 671
Score = 155 bits (376), Expect = 2e-36
Identities = 92/244 (37%), Positives = 131/244 (53%), Gaps = 13/244 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRKLN 60
E+ ++ +T +G G+ G VY G G VAVK ++E E ++ +++L
Sbjct: 428 EILWDDLTIGEQIGRGSCGTVYHGIWFGSDVAVKVFSKQEYSESVIKSFEKEVSLMKRLR 487
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTP-RQIIRWAKDIAQGMVYLH 119
H N++ F G + + CI+ EF G L+ L S R+ I A DIA+GM YLH
Sbjct: 488 HPNVLLFMGAVTSPQRLCIVSEFVPRGSLFRLLQRSMSKLDWRRRINMALDIARGMNYLH 547
Query: 120 --NRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIRHE 176
+ IIHRDLKS N+LV N KV+DFG SR + S GT WMAPEV+R+E
Sbjct: 548 CCSPPIIHRDLKSSNLLVDRNWTVKVADFGLSRIKHQTYLTSKSGKGTPQWMAPEVLRNE 607
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
E+ D++SFGVVLWEL T++IP++ L + ++ VG L +P L+
Sbjct: 608 SADEKSDIYSFGVVLWELATEKIPWENLNSMQVIGAVGFMNQRLEIPKDTDPDWISLIES 667
Query: 237 CWDR 240
CW R
Sbjct: 668 CWHR 671
>UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1;
Ostreococcus tauri|Rep: Protein kinase family protein -
Ostreococcus tauri
Length = 641
Score = 155 bits (376), Expect = 2e-36
Identities = 95/248 (38%), Positives = 132/248 (53%), Gaps = 22/248 (8%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKE-----------ETDIMHLRKLNHDNIVRFRGV 70
+G G+ G V+ RG VAVK+ +++ E DIM R+L H N+V G
Sbjct: 342 IGIGSFGEVHRALWRGTEVAVKRFLDQDISRNLLDEVTFEIDIM--RRLRHPNVVLLMGA 399
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHS------GASFTPRQIIRWAKDIAQGMVYLHNRK-- 122
+ N I+ EF G L+ LH A+ R+ +R A D+ +GM YLH+ +
Sbjct: 400 VTVPGNLSIVTEFLHRGSLFKLLHREQPPAVAAALDNRRRMRMAMDVVRGMHYLHSFEPM 459
Query: 123 IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIRHEPCSER 181
I+HRDLKSPN+LV + V KV DFG SR N + + GT WMAPEV+R+E E+
Sbjct: 460 IVHRDLKSPNLLVDKSFVVKVCDFGLSRMKRNTYLSSKTNAGTPEWMAPEVLRNEASDEK 519
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWSFGV+LWEL T P++ L ++ VG L +P+ E + + CW
Sbjct: 520 ADVWSFGVILWELATVLEPWQGLNPMQVVGAVGFAGKQLEIPSDVDEVIANMCRDCWQTN 579
Query: 242 PRNRPPFK 249
PR RP F+
Sbjct: 580 PRERPSFE 587
>UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1105
Score = 155 bits (375), Expect = 3e-36
Identities = 94/295 (31%), Positives = 149/295 (50%), Gaps = 16/295 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKE---------ETDI 53
S E W++ I + SG G V+ G + +VAVK+L ++ + ++
Sbjct: 199 SIEQWDIDPADIKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGLEMFKGEV 258
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTPRQIIRWAKD 110
L L H I+ F G C++ +CII +F L+ LH+ + TP Q+ A
Sbjct: 259 AILAHLRHFAILPFVGACTKPP-FCIITKFMSGDSLFARLHAKDANSRLTPTQLSIIALG 317
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMA 169
+A GM YLH++ ++HRDLKS N+L+ ++ + K++DFG +R + N V GT WMA
Sbjct: 318 VAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNNEMVSGGIGTSQWMA 377
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
PEV+ + E+ DV+S+G++LWE+LT ++PY+ L + V + +P SCP++
Sbjct: 378 PEVLMSQNFDEKSDVYSYGIILWEMLTGDVPYRGLRDIQVAMTVINQNNRPKIPKSCPQN 437
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENE 284
L + CW P RP F I+ L+ F D A + E NE
Sbjct: 438 LAKFIRLCWHSDPHKRPDFTTIVQTLETGTICFPNTDIDELKAYVAQHQSESNNE 492
>UniRef50_A4S4M0 Cluster: Predicted protein; n=1; Ostreococcus
lucimarinus CCE9901|Rep: Predicted protein -
Ostreococcus lucimarinus CCE9901
Length = 316
Score = 154 bits (374), Expect = 4e-36
Identities = 95/278 (34%), Positives = 149/278 (53%), Gaps = 30/278 (10%)
Query: 8 DWEVPFESI-------TDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ET 51
+WE+ ++ I + +G G G V+ G G +VAVKKL ++
Sbjct: 6 EWEIDYKDIEFEGGVPSSQNRIGHGGFGEVFLGRYHGSLVAVKKLFNQDMMGKGLSDFRR 65
Query: 52 DIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKD 110
++ L +L H +IV + G C++ N I++E+ G L+ FLH + +T + RWA
Sbjct: 66 EVQILSRLRHPSIVLWLGACTQAPNLTIVLEYMDKGSLHQFLHRTTTPYTTLTLTRWAMT 125
Query: 111 IAQGMVYLHNRK---IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE--SAVMSFTGTV 165
IAQGMVYLH+ K I+H DL + NVLV + + K++DFG S+ + S TGTV
Sbjct: 126 IAQGMVYLHSAKPFPIVHCDLNTNNVLVNRDGMVKITDFGLSKVKHSSRLSRQTGMTGTV 185
Query: 166 AWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETIL------ 219
+ +PEVIR SE DV+++GV+LWELLT+ IP++ L + I++ + ++
Sbjct: 186 NYASPEVIRGGKFSEASDVFAYGVILWELLTRRIPWEDLNEYQIVFQMTSDLDASLAATA 245
Query: 220 --LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
L +P S PE + +++ W P R FK +L L
Sbjct: 246 KNLELPASAPEGYRKIIHGAWATQPERRSAFKDVLGDL 283
>UniRef50_A2FGN8 Cluster: TKL family protein kinase; n=2;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 790
Score = 154 bits (374), Expect = 4e-36
Identities = 92/267 (34%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREKEET---------D 52
L+ ++W V + +GSG VVYSG E+VA+KKL+ ++ T +
Sbjct: 197 LNYQNWRVKHSDLLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGPQLQAFQRE 256
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIA 112
+ L H I++F G ++ +C++ +F G LY LH S P + D+A
Sbjct: 257 LSILATAVHPTILKFIGA-TDTHPFCVVTQFMPGGTLYYDLHQRHSLDPTDLTIALYDVA 315
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEV 172
+GM +LH + IIHRDLK+ NVL+ D AK+SDFG S++ D+ + GT WMAPE+
Sbjct: 316 RGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQMDSNQLMTMNVGTPHWMAPEL 375
Query: 173 IRHE----PCSE---RVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNS 225
+ + P ++ +VDV++F +V+WE L +EIPY +E I+ V + +P
Sbjct: 376 LANNGPQTPGAQYDTKVDVYAFAIVMWEALVKEIPYHGMEPMQIVAQVMMNDLRPHIPKD 435
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIIL 252
P + + L+ QCW R P RP F I+
Sbjct: 436 TPPAFEDLMKQCWARNPTMRPNFAEIV 462
>UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 960
Score = 154 bits (374), Expect = 4e-36
Identities = 93/249 (37%), Positives = 138/249 (55%), Gaps = 19/249 (7%)
Query: 22 LGSGAQGVVYSGNLRG--EMVAVKKLREK--EETDIMHLRK-------LNHDNIVRFRGV 70
+G G G VY G+ + + +A+K L ++ + D+ R+ L+H ++ +F G
Sbjct: 177 IGRGQSGTVYLGHFKDSDDNIAIKVLSKQTLSQADVESYRREVYFLTILSHPSLTKFCGY 236
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASF---TPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
+ Y I EF G LY L + T R +I A +A+G+ YLH++ +IHRD
Sbjct: 237 TEDAPFY-ICTEFMSGGSLYHKLRNNPEQLNPTTRSLI--ALTVARGLEYLHSKGVIHRD 293
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP-CSERVDVWS 186
LKS NVL+ DN AK+ DFG R D+ + GTV WMAPEV+ P ERVDV+S
Sbjct: 294 LKSLNVLLDDNNNAKICDFGMVRTRDSR-PMTGMIGTVHWMAPEVLMSTPFYDERVDVYS 352
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
FG+ LWELLT ++PYK ++ + I+ V P+P CP+ L L+ +CW + P +RP
Sbjct: 353 FGIFLWELLTGQMPYKDMQANQIIRTVTELGERPPIPEDCPQHLAKLITKCWSQDPEDRP 412
Query: 247 PFKIILAHL 255
++A L
Sbjct: 413 TMAKVVAEL 421
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase
Yes; n=422; root|Rep: Proto-oncogene tyrosine-protein
kinase Yes - Homo sapiens (Human)
Length = 543
Score = 154 bits (374), Expect = 4e-36
Identities = 97/265 (36%), Positives = 140/265 (52%), Gaps = 14/265 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHL 56
L+++ WE+P ES+ + LG G G V+ G G VA+K L+ E + +
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQG 114
+KL HD +V V SE Y I+ EF G L DFL G + Q++ A IA G
Sbjct: 325 KKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNE-SAVMSFTGTVAWMAPEV 172
M Y+ IHRDL++ N+LV +NLV K++DFG +R DNE +A + W APE
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + + DVWSFG++ EL+T+ +PY + +L V +P P CPESL
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLH 502
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
L+N CW + P RP F+ I + L+
Sbjct: 503 ELMNLCWKKDPDERPTFEYIQSFLE 527
>UniRef50_A2E2L8 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 797
Score = 154 bits (373), Expect = 5e-36
Identities = 101/310 (32%), Positives = 161/310 (51%), Gaps = 22/310 (7%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSG--NLRGEMVAVKKLR---------EKEETD 52
L+ + W + + + + +G G VVY G N VA+K+L+ + + +
Sbjct: 194 LNYQSWRLNHKDLNKVKEIGHGVSSVVYYGYDNRTKNEVAIKELKYPILSGPSLNQFQRE 253
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIA 112
+ L H ++ F G +E YCI+ E+ G LY+ LHS P + DIA
Sbjct: 254 LTVLATARHPRVLGFVGA-TETAPYCIVTEWMGGGTLYNILHSPKPTNPTMLSICMYDIA 312
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEV 172
+GM +LH+R I+HRDLKS NVL + +A + DFG SR D++ + GT WMAPE+
Sbjct: 313 RGMQFLHSRHIVHRDLKSLNVLFDNKGLAHIGDFGFSRREDDK--MTQSIGTPHWMAPEL 370
Query: 173 IRHEP-CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + +VDV+++G+VLWE+LT++ PY ++ I+ V + +P + P L
Sbjct: 371 LATGSFYTNKVDVYAYGIVLWEILTKQYPYNLMDPQQIVAQVLANDLRPEIPENSPPRLA 430
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD-----IAGAEFSRVLPDRFS-VTQATWRK-EIENE 284
L+ +CWDR P RP F I++ L + GA+ L VTQ + + IE++
Sbjct: 431 SLIKKCWDRNPDARPSFDRIVSELQQGNTLLEGADRKVFLEYTAQFVTQISDQSYHIESQ 490
Query: 285 MKEIYTRNKE 294
++E T N E
Sbjct: 491 LEEQTTTNDE 500
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 154 bits (373), Expect = 5e-36
Identities = 96/267 (35%), Positives = 139/267 (52%), Gaps = 21/267 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEM------VAVKKLR----EKEETDIMH---- 55
E+ +T +G+G G VY G L+ VA+K L+ EK+ D +
Sbjct: 607 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI 666
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
+ + +H NI+R GV S+ + II E+ + G L FL F+ Q++ + IA G
Sbjct: 667 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 726
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAP 170
M YL N +HRDL + N+LV NLV KVSDFG SR E D E+ + G + W AP
Sbjct: 727 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 786
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I + + DVWSFG+V+WE++T E PY L H ++ + + LP P CP +
Sbjct: 787 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSA 845
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
+ L+ QCW + RP F I++ LD
Sbjct: 846 IYQLMMQCWQQERARRPKFADIVSILD 872
>UniRef50_P83104 Cluster: Putative mitogen-activated protein kinase
kinase kinase 7-like; n=3; Sophophora|Rep: Putative
mitogen-activated protein kinase kinase kinase 7-like -
Drosophila melanogaster (Fruit fly)
Length = 393
Score = 153 bits (372), Expect = 7e-36
Identities = 84/249 (33%), Positives = 142/249 (57%), Gaps = 20/249 (8%)
Query: 21 YLGSGAQGVVYSGNLRGEMVAVK-------KLREKEETDIMHLRKLNHDNIVRFRGVCSE 73
+LG+G+ G V + + +AVK +++ E +I HL +++H+N++R G S
Sbjct: 16 FLGAGSGGAVRKATFQNQEIAVKIFDFLEETIKKNAEREITHLSEIDHENVIRVIGRASN 75
Query: 74 GENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYLHN--RKIIHRDLK 129
G+ ++ME+ + G L+++L+ +T Q +RWA A+ + YLH+ R I+HRD+K
Sbjct: 76 GKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIK 135
Query: 130 SPNVLVADNLV-AKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFG 188
N+L+ + K+ DFG + + N M GT+ +MAPE I+H + + DV+SFG
Sbjct: 136 PQNMLLYNQHEDLKICDFGLATDMSNNKTDMQ--GTLRYMAPEAIKHLKYTAKCDVYSFG 193
Query: 189 VVLWELLTQEIPYKTLET----HAILWGV--GTETILLPVPNSCPESLKLLLNQCWDRVP 242
++LWEL+T+++PY LE +AI+ + G + + V + CPE +K L+ C D P
Sbjct: 194 IMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINP 253
Query: 243 RNRPPFKII 251
RP K I
Sbjct: 254 EKRPSMKEI 262
>UniRef50_Q4H2Q7 Cluster: Mitogen-activated protein kinase kinase
kinase; n=1; Ciona intestinalis|Rep: Mitogen-activated
protein kinase kinase kinase - Ciona intestinalis
(Transparent sea squirt)
Length = 608
Score = 153 bits (371), Expect = 1e-35
Identities = 92/263 (34%), Positives = 142/263 (53%), Gaps = 20/263 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ + + +G G+ GVVY R VAVK + + E T++ L ++ H NI
Sbjct: 17 EIDYNEMELKEVVGKGSFGVVYLAIWRNIQVAVKMIESESERIAFMTELRQLSRVCHPNI 76
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHNR 121
+R G C + ++MEF + G LY+ LH + +T + W A G+ YLHN
Sbjct: 77 IRLYGACRNPVS--LVMEFAECGSLYNLLHGPGNQPHYTSGHAMSWCLQCATGVQYLHNM 134
Query: 122 K---IIHRDLKSPNVLVADN-LVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
K +IHRDLK PN+L+ +N V K+ DFGT+ D + + + G+ AWMAPEV
Sbjct: 135 KPKALIHRDLKPPNLLLTNNGTVLKICDFGTA--CDQHTHMTNNKGSAAWMAPEVFEGCQ 192
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE+LT+ P+ L A I+W V T + CP+ ++ L+
Sbjct: 193 YSEKCDVFSWGIILWEVLTRRKPFDDLGGPAFRIMWAVHTGA-RPDLIQGCPQPVESLMT 251
Query: 236 QCWDRVPRNRPPF-KIILAHLDI 257
+CW P RP +I++A D+
Sbjct: 252 RCWSAKPNERPSMDEIVVAMSDL 274
>UniRef50_O43318 Cluster: Mitogen-activated protein kinase kinase
kinase 7; n=46; Euteleostomi|Rep: Mitogen-activated
protein kinase kinase kinase 7 - Homo sapiens (Human)
Length = 606
Score = 153 bits (371), Expect = 1e-35
Identities = 87/257 (33%), Positives = 142/257 (55%), Gaps = 19/257 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
E+ ++ I +G GA GVV R + VA+K++ + E ++ L ++NH NI
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLHN- 120
V+ G C C++ME+ + G LY+ LH +T + W +QG+ YLH+
Sbjct: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
Query: 121 --RKIIHRDLKSPNVL-VADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+ +IHRDLK PN+L VA V K+ DFGT+ D ++ + + G+ AWMAPEV
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN 205
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ DV+S+G++LWE++T+ P+ + A I+W V T P+ + P+ ++ L+
Sbjct: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGT-RPPLIKNLPKPIESLMT 264
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW + P RP + I+
Sbjct: 265 RCWSKDPSQRPSMEEIV 281
>UniRef50_Q6ER39 Cluster: CTR1-like kinase kinase kinase-like; n=5;
Magnoliophyta|Rep: CTR1-like kinase kinase kinase-like -
Oryza sativa subsp. japonica (Rice)
Length = 790
Score = 153 bits (370), Expect = 1e-35
Identities = 88/262 (33%), Positives = 139/262 (53%), Gaps = 17/262 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLR 57
E+W + F IT +G G G V+ G G VA+K E++ T +I L
Sbjct: 525 EEWHIEFSEITVGTRVGIGFFGEVFRGIWNGTDVAIKLFLEQDLTTENMEDFCNEISILS 584
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQG 114
+L H N++ F G C + + ++ E+ + G LY +H+ + R+ ++ +DI +G
Sbjct: 585 RLRHPNVILFLGACMKPPHLSLVTEYMEMGSLYYLIHASGQKGKLSWRRRLKMLRDICRG 644
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAV-MSFTGTVAWMAPEVI 173
++ +H KI+HRDLKS N LV + K+ DFG SR N + S GT WMAPE+I
Sbjct: 645 LMCMHRLKIVHRDLKSANCLVNKHWAVKLCDFGLSRVMSNSAMNDNSSAGTPEWMAPELI 704
Query: 174 RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
R+EP +E+ D++S GV++WEL T P++ + + +++ V E L +P+ L L
Sbjct: 705 RNEPFTEKCDIFSLGVIMWELCTLSRPWEGIPSVQVVYNVANEGARLEIPDG---PLGSL 761
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW P RP + IL L
Sbjct: 762 IADCWAE-PDKRPGCQEILTRL 782
>UniRef50_Q0IR49 Cluster: Os11g0678000 protein; n=7; Oryza
sativa|Rep: Os11g0678000 protein - Oryza sativa subsp.
japonica (Rice)
Length = 755
Score = 153 bits (370), Expect = 1e-35
Identities = 91/246 (36%), Positives = 131/246 (53%), Gaps = 18/246 (7%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHL---------RK 58
D+E+ +E + +G G+ G VY G VAVK + E ++ M L +K
Sbjct: 431 DFEILWEDLAIGEQVGQGSCGTVYHALWYGSDVAVKVFSKYEYSEDMILTFRQEVALMKK 490
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVY 117
L H N++ F G + + CI+ EF G L+ L A PR+ + A DIA+GM Y
Sbjct: 491 LRHPNVILFMGAVASLQRLCIVTEFLPRGSLFRLLQKNAGKLDPRRRVHMAIDIARGMNY 550
Query: 118 LHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
LHN I+HRDLKS N+LV N KV+DFG SR + + + GT WMAPEV+R
Sbjct: 551 LHNSSPPIVHRDLKSSNLLVDKNWTVKVADFGLSRLKLETFLTTKTGKGTPQWMAPEVLR 610
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+EP +E ++GV+LWE+ TQ+IP+ L T ++ VG L +P+ ++
Sbjct: 611 NEPSNE-----NYGVILWEIATQKIPWDNLNTMQVVGAVGFMDHRLDIPSDVDPHWASMI 665
Query: 235 NQCWDR 240
CWDR
Sbjct: 666 ESCWDR 671
>UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1;
Dictyostelium discoideum AX4|Rep: Protein kinase, TKL
group - Dictyostelium discoideum AX4
Length = 690
Score = 153 bits (370), Expect = 1e-35
Identities = 90/247 (36%), Positives = 130/247 (52%), Gaps = 13/247 (5%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLRE--------KE-ETDIMHLRKLNHDNIVRFRGVCS 72
+G G G VY G RG VAVKKL KE +I ++ L H N+++F G C
Sbjct: 397 IGKGNFGEVYLGTWRGSQVAVKKLPAHNINENILKEFHREINLMKNLRHPNVIQFLGSCL 456
Query: 73 EGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMVYLHNRK--IIHRDLK 129
+ CI E+ G LY LH+ ++ R D A+G++YLH I+HRDLK
Sbjct: 457 ISPDICICTEYMPRGSLYSILHNEKIKISWSLVKRMMIDAAKGIIYLHGSTPVILHRDLK 516
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
S N+LV +N KV+DFG S + + A M+ GT W +PEV+R + +E+ DV+SFG+
Sbjct: 517 SHNLLVDENWKVKVADFGLSTI-EQQGATMTACGTPCWTSPEVLRSQRYTEKADVYSFGI 575
Query: 190 VLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFK 249
+LWE T++ PY + +++ VG E + P P P LL C + P RP +
Sbjct: 576 ILWECATRQDPYFGIPPFQVIFAVGREGMRPPTPKYGPPKYIQLLKDCLNENPSQRPTME 635
Query: 250 IILAHLD 256
L L+
Sbjct: 636 QCLEILE 642
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 153 bits (370), Expect = 1e-35
Identities = 89/253 (35%), Positives = 132/253 (52%), Gaps = 12/253 (4%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET------DIMHLRKL 59
+E W VP E + +G G G VY G + VA+KKLR+ +T + + L
Sbjct: 203 KEGWAVPIEDVEFKELIGKGEFGNVYKGVWAKKTVAIKKLRDDSKTAQSLLAEASVMTTL 262
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQGMVY 117
H N+V + +G++ I+ E+C+ G L ++L + A T + +A D+ GM Y
Sbjct: 263 QHKNLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGFAIDVCNGMRY 322
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
L + IIHRDL + NVL++D L AKVSDFG +++ + E A F V W APE I +
Sbjct: 323 LEEKNIIHRDLAARNVLLSDELCAKVSDFGLAKDVEQELASGKF--PVKWTAPEAIELKI 380
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFG++LWE+ + PY +L + + P CP + L+ +
Sbjct: 381 FSTKSDVWSFGILLWEIFSFGRNPYPREPLDELLTKI-KSNYRMECPEKCPPFVYQLMLK 439
Query: 237 CWDRVPRNRPPFK 249
CWD P RP FK
Sbjct: 440 CWDADPSRRPSFK 452
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 152 bits (368), Expect = 2e-35
Identities = 88/265 (33%), Positives = 137/265 (51%), Gaps = 12/265 (4%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRK------L 59
+ WE+ E + +G G G V G L+GE VAVK L++ L + L
Sbjct: 479 DNGWEIKMEDLQLKENIGKGEFGDVMLGILKGEKVAVKVLKDAGRASNKFLAEAGVMTTL 538
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVY 117
H+N+V+F G+ + ++ E+ G L D+L S T R I +A D GM Y
Sbjct: 539 EHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDTCSGMEY 598
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
L +K+IHRDL + NVL+++ VAKVSDFG +R+ + +A +S + W APE ++
Sbjct: 599 LEMKKVIHRDLAARNVLISEECVAKVSDFGLARD-ERYTADISKL-PIKWTAPEALKEGK 656
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + D+WSFG++LWE+ + +PY + ++ VG+ + P CP + ++ Q
Sbjct: 657 FSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVGS-GYKMEAPEGCPPEIYEMMRQ 715
Query: 237 CWDRVPRNRPPFKIILAHLDIAGAE 261
WD VP RP F + L + E
Sbjct: 716 AWDLVPEKRPTFAELKRRLAVCKRE 740
>UniRef50_A2EAR6 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 800
Score = 152 bits (368), Expect = 2e-35
Identities = 92/259 (35%), Positives = 143/259 (55%), Gaps = 14/259 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREKEET---------DIMH 55
+ W + E + +GSG V+ G + G VA+KKL+ K+ T +I
Sbjct: 198 QQWRINLEDFEMIKEIGSGISSNVFYGRCKSTGLPVAIKKLKFKKLTGIKLQTFQREISI 257
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGM 115
L +H +++F G ++ + YCII E+ LY LH + A DIA+GM
Sbjct: 258 LAATSHPCLLKFVGA-TDTQPYCIITEWMDRDTLYRELHKTKMLNATKKTIVAFDIARGM 316
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAPEVIR 174
YLH++ IIHRDLKS NVL+ + AK+ DFG SR +D+E ++++ GT WMAPE++
Sbjct: 317 QYLHSKHIIHRDLKSLNVLLNEEGQAKIGDFGYSRSYDSEDSLLTQNIGTPHWMAPELLD 376
Query: 175 HEP-CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ +VDV+++ +VLWE++T PY+ L+ I+ V + P+P + LK L
Sbjct: 377 GTTNYTNKVDVYAYAIVLWEIITGLQPYQGLDPPQIIAQVMIHDLRPPLPQTVNPGLKDL 436
Query: 234 LNQCWDRVPRNRPPFKIIL 252
+ +CWDR P RP F+ I+
Sbjct: 437 ITRCWDRNPDRRPSFEEIV 455
>UniRef50_Q9FRR5 Cluster: F22O13.20; n=37; Eukaryota|Rep: F22O13.20 -
Arabidopsis thaliana (Mouse-ear cress)
Length = 2651
Score = 151 bits (365), Expect = 5e-35
Identities = 91/248 (36%), Positives = 130/248 (52%), Gaps = 24/248 (9%)
Query: 25 GAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMH-----------LRKLNHDNI 64
G+ G VY + G VAVKK +++ +++ H +R+L H N+
Sbjct: 777 GSYGEVYHADWHGTEVAVKKFLDQDFSGAALAEFRSEVSHKFTCVYLLVRIMRRLRHPNV 836
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRK- 122
V F G + N I+ EF G LY LH S R+ I+ A D+A GM LH
Sbjct: 837 VFFLGAVTRPPNLSIVTEFLPRGSLYRILHRPKSHIDERRRIKMALDVAMGMNCLHTSTP 896
Query: 123 -IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIRHEPCSE 180
I+HRDLK+PN+LV +N KV DFG SR N + S GT WMAPEV+R+EP +E
Sbjct: 897 TIVHRDLKTPNLLVDNNWNVKVGDFGLSRLKHNTFLSSKSTAGTPEWMAPEVLRNEPSNE 956
Query: 181 RVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
+ DV+SFGV+LWEL T +P++ + ++ VG + L +P + ++ +CW
Sbjct: 957 KCDVYSFGVILWELATLRLPWRGMNPMQVVGAVGFQNRRLEIPKELDPVVGRIILECWQT 1016
Query: 241 VPRNRPPF 248
P RP F
Sbjct: 1017 DPNLRPSF 1024
>UniRef50_A7QMH3 Cluster: Chromosome chr19 scaffold_126, whole genome
shotgun sequence; n=3; Vitis vinifera|Rep: Chromosome
chr19 scaffold_126, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 1121
Score = 151 bits (365), Expect = 5e-35
Identities = 100/271 (36%), Positives = 139/271 (51%), Gaps = 24/271 (8%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEETDIMHLR------K 58
E + ++ LGSG G VY G RG VA+K+++ E+E I R K
Sbjct: 838 EDLEELKELGSGTFGTVYHGKWRGSDVAIKRIKKICFTSRSSEQERLTIEFWREADILSK 897
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPL-YDFLHSGASFTPRQIIRWAKDIAQGM 115
L+H N+V F GV +G + + E+ G L + L R+ + A D A GM
Sbjct: 898 LHHPNVVAFYGVVHDGPGATLATVTEYMVDGSLRHVLLRKDRYLDRRKRLLIAMDAAFGM 957
Query: 116 VYLHNRKIIHRDLKSPNVLV--ADNL--VAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH++ I+H DLK N+LV D L + KV DFG S+ N GT+ WMAPE
Sbjct: 958 EYLHSKNIVHFDLKCDNLLVNLKDPLRPICKVGDFGLSKIKRNTLVSGGVRGTLPWMAPE 1017
Query: 172 VIR--HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ SE+VDV+SFG+VLWE+LT E PY + AI+ G+ + T+ VP+SC
Sbjct: 1018 LLNGSSNKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVSNTLRPTVPSSCDPE 1077
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLDIAGA 260
+ L+ QCW P RP F I L + A
Sbjct: 1078 WRTLMEQCWAPNPAVRPSFTEITGRLRVMSA 1108
>UniRef50_Q9LRY7 Cluster: Similarity to protein kinase; n=3;
Arabidopsis thaliana|Rep: Similarity to protein kinase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 1117
Score = 150 bits (364), Expect = 7e-35
Identities = 97/264 (36%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEET------DIMHLRKLN 60
+ D+ LGSG G VY G RG VA+K++R E+E + L L+
Sbjct: 836 LEDLTELGSGTYGTVYHGTWRGTDVAIKRIRNSCFAGRSSEQERLTKDFWREAQILSNLH 895
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPL-YDFLHSGASFTPRQIIRWAKDIAQGMVY 117
H N+V F G+ +G + + EF G L + L R+ I A D A GM Y
Sbjct: 896 HPNVVAFYGIVPDGTGGTLATVTEFMVNGSLRHALLKKDRLLDTRKKIIIAMDAAFGMEY 955
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LH++ I+H DLK N+LV + KV D G SR N GT+ WMAPE++
Sbjct: 956 LHSKNIVHFDLKCENLLVNLRDPQRPICKVGDLGLSRIKRNTLVSGGVRGTLPWMAPELL 1015
Query: 174 RHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+S+G+ LWE+LT E PY + AI+ G+ T+ P+P SC K
Sbjct: 1016 NGSSTRVSEKVDVFSYGISLWEILTGEEPYADMHCGAIIGGIVKNTLRPPIPKSCSPEWK 1075
Query: 232 LLLNQCWDRVPRNRPPFKIILAHL 255
L+ QCW P +RPPF I L
Sbjct: 1076 KLMEQCWSVDPDSRPPFTEITCRL 1099
>UniRef50_P11346 Cluster: Raf homolog serine/threonine-protein
kinase dRAF-1; n=8; Endopterygota|Rep: Raf homolog
serine/threonine-protein kinase dRAF-1 - Drosophila
melanogaster (Fruit fly)
Length = 739
Score = 150 bits (364), Expect = 7e-35
Identities = 96/272 (35%), Positives = 144/272 (52%), Gaps = 22/272 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMH 55
SEE+W + E I +GSG+ G VY + G VAVK L K + ++
Sbjct: 418 SEENWNILAEEILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKTPSPAQLQAFKNEVAM 476
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQG 114
L+K H NI+ F G C + I+ ++C+ LY +H S F +I + +AQG
Sbjct: 477 LKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQG 535
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + ++L K+ DFG W E TG++ WMAPE
Sbjct: 536 MDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPE 595
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLET-HAILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+V++ELL + +PY + IL+ VG + + V +
Sbjct: 596 VIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRS 655
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P++LK L C P++RP F+ +L L+
Sbjct: 656 DAPQALKRLAEDCIKYTPKDRPLFRPLLNMLE 687
>UniRef50_Q5XTZ4 Cluster: Salt-inducible protein kinase; n=2;
Poaceae|Rep: Salt-inducible protein kinase - Zea mays
(Maize)
Length = 323
Score = 150 bits (363), Expect = 9e-35
Identities = 98/266 (36%), Positives = 134/266 (50%), Gaps = 24/266 (9%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-------REKEETDIMH--------LRK 58
E + ++ LGSGA G VY G RG VA+K++ R E + H L K
Sbjct: 44 EDLEELRELGSGAFGTVYHGKWRGSDVAIKRIKKSCFTGRSSELERLAHEFWREAEILSK 103
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGASFTPRQI-IRWAKDIAQGM 115
L+H N+V F GV +G + + EF G L L + R+ + A D A G+
Sbjct: 104 LHHPNVVAFYGVVKDGPGGTLATVTEFMVNGSLRHVLQRKDKYLDRRKRLIIAMDAAFGL 163
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH++ I+H DLK N+LV + KV DFG S+ N A GT+ WMAPE
Sbjct: 164 EYLHSKNIVHVDLKCDNLLVNLKDQSRPICKVGDFGLSKIKRNTLASGGVRGTLPWMAPE 223
Query: 172 VIR--HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ SE+VDV+SFG+V+WE+LT E PY + AI+ G+ T+ VP SC
Sbjct: 224 LLNGSSNKVSEKVDVFSFGIVMWEILTGEEPYANMHYGAIIGGIVNNTLRPHVPASCDPE 283
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 284 WRRLMEQCWAPDPAQRPAFTEIAGRL 309
>UniRef50_Q0DE32 Cluster: Os06g0181200 protein; n=5; Oryza
sativa|Rep: Os06g0181200 protein - Oryza sativa subsp.
japonica (Rice)
Length = 491
Score = 150 bits (363), Expect = 9e-35
Identities = 97/278 (34%), Positives = 137/278 (49%), Gaps = 24/278 (8%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-----------REKEETDIMH----LRKLN 60
+ ++ LGSG G VY G RG VA+K++ +E+ TD + L L+
Sbjct: 214 LEELRELGSGTFGTVYHGKWRGSDVAIKRINDRCFAGKASEQERMRTDFWNEADKLASLH 273
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVY 117
H N+V F GV +G + + E+ G L L F R+ + A D+A GM Y
Sbjct: 274 HPNVVAFYGVVLDGPGGSVATVTEYMANGSLRQALQRHEKIFDRRRRLLIAMDVAFGMEY 333
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LH + I+H DLKS N+LV + + KV D G S+ GT+ WMAPE++
Sbjct: 334 LHEKNIVHFDLKSDNLLVNLRDPQHPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELL 393
Query: 174 RHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+SFG+V+WELLT E PY L AI+ G+ T+ PVP SC +
Sbjct: 394 NGSSSLVSEKVDVFSFGIVMWELLTGEEPYAELHYGAIIGGIVNNTLRPPVPESCDPRWR 453
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDR 269
L+ QCW P RP F + L ++ P +
Sbjct: 454 SLMEQCWSSEPSERPSFTEVGKRLRAMATPSTKAQPQK 491
>UniRef50_O64768 Cluster: Putative uncharacterized protein At2g35050;
n=1; Arabidopsis thaliana|Rep: Putative uncharacterized
protein At2g35050 - Arabidopsis thaliana (Mouse-ear
cress)
Length = 1257
Score = 150 bits (363), Expect = 9e-35
Identities = 95/265 (35%), Positives = 135/265 (50%), Gaps = 23/265 (8%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-----------EKEETDIMH----LRK 58
+ + ++ LGSG G VY G RG VA+K+++ E+ ++ H L K
Sbjct: 972 DDLEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQERLTSEFWHEAEILSK 1031
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMV 116
L+H N++ F GV +G + + E+ G L L S R+ + A D A GM
Sbjct: 1032 LHHPNVMAFYGVVKDGPGGTLATVTEYMVNGSLRHVLLSNRHLDRRKRLIIAMDAAFGME 1091
Query: 117 YLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEV 172
YLH++ I+H DLK N+LV + KV DFG S+ N GT+ WMAPE+
Sbjct: 1092 YLHSKSIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMAPEL 1151
Query: 173 IR--HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ SE+VDV+SFG+VLWE+LT E PY + AI+ G+ T+ VPN C
Sbjct: 1152 LSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPTVPNYCDPEW 1211
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHL 255
++L+ QCW P RP F I L
Sbjct: 1212 RMLMEQCWAPDPFVRPAFPEIARRL 1236
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 150 bits (363), Expect = 9e-35
Identities = 88/270 (32%), Positives = 138/270 (51%), Gaps = 14/270 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-----EKEETDIMH----L 56
E+ W +P S+ +G G G V+ G+ G+ VA+K ++ EK +T + +
Sbjct: 216 EKGWAIPKASLLKKSLIGKGEFGEVWLGDYEGKKVAMKSMKDHLKDEKAKTQFLAEASVM 275
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
L H N+V G+ + +I EF G L D+L S A T + I +A+D+ +G
Sbjct: 276 TTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDFARDVVKG 335
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
MVYL ++ +HRDL + NVL+A++ VAKVSDFG ++ N + V W APE +R
Sbjct: 336 MVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAKSSSNVKQEGAKL-PVKWTAPEALR 394
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFGV+LWE+ + +PY + + V + P+ CP+ + +
Sbjct: 395 ENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANHV-ENGYRMESPDGCPDQIYKI 453
Query: 234 LNQCWDRVPRNRPPFKIILAHLDIAGAEFS 263
+ CW++ P RP F I L+ S
Sbjct: 454 MMDCWEKDPSQRPNFTRIEKALESVAVAMS 483
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 150 bits (363), Expect = 9e-35
Identities = 87/256 (33%), Positives = 138/256 (53%), Gaps = 16/256 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK-------EETDIMHL 56
L+ W + + +T +G G G V G G+ VAVK ++ +ET +M
Sbjct: 223 LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVM-- 280
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQG 114
K+ H+N+VR GV Y I+ME G L +FL + A Q+++++ +A+G
Sbjct: 281 TKMQHENLVRLLGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEG 339
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M YL ++K++HRDL + N+LV+++LVAKVSDFG ++ + S V W APE ++
Sbjct: 340 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA--ERKGLDSSRLPVKWTAPEALK 397
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H + + DVWSFGV+LWE+ + PY + + V + P P CP + +L
Sbjct: 398 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVHVL 456
Query: 234 LNQCWDRVPRNRPPFK 249
++ CW+ P RPPF+
Sbjct: 457 MSSCWEAEPARRPPFR 472
>UniRef50_UPI00015B4F3C Cluster: PREDICTED: similar to CG2845-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG2845-PA - Nasonia vitripennis
Length = 789
Score = 149 bits (362), Expect = 1e-34
Identities = 103/272 (37%), Positives = 143/272 (52%), Gaps = 22/272 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S EDWE+P + I +GSG+ G VY + G VAVK L K T ++
Sbjct: 465 SIEDWEIPADEILVGQRIGSGSFGTVYKAHWHGP-VAVKTLNVKIPTSAQLQAFKNEVAV 523
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQG 114
LRK H NI+ F G C I+ ++C+ LY LH S F +I + AQG
Sbjct: 524 LRKTRHVNILLFMG-CVSKPQLAIVTQWCEGSSLYKHLHVFESKFQLLTLIEIGRQTAQG 582
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSF---TGTVAWMAPE 171
M YLH + IIHRDLKS N+ + D+L K+ DFG + S + F TG++ WMAPE
Sbjct: 583 MDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATAKTRWSGSLQFHQPTGSILWMAPE 642
Query: 172 VIR---HEPCSERVDVWSFGVVLWELLTQEIPYKTLET-HAILWGVGTETI---LLPVPN 224
VIR P S + DV++FGVVL+ELL ++PY + IL+ VG + L + +
Sbjct: 643 VIRMQEENPYSFQSDVYAFGVVLFELLAGQLPYSHVNNKDQILFMVGRGYLRPDLNKLRS 702
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P++L+ L C +RP F+ ILA L+
Sbjct: 703 DTPKALRRLTEDCIKFSRDDRPIFRQILASLE 734
>UniRef50_Q7ZTR8 Cluster: Serine/Threonine protein kinase RAF1;
n=14; Euteleostomi|Rep: Serine/Threonine protein kinase
RAF1 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 643
Score = 149 bits (362), Expect = 1e-34
Identities = 94/269 (34%), Positives = 145/269 (53%), Gaps = 22/269 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WE+ + + +GSG+ G V+ G G+ VAVK L+ T ++ LRK
Sbjct: 338 WEIEANEVVLLSRIGSGSFGTVHKGKWHGD-VAVKVLKVTNPTPEQFQAFRNEVAVLRKT 396
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G ++G N I+ ++C+ LY LH +F Q+I A+ AQGM YL
Sbjct: 397 RHVNILLFMGYMTKG-NLAIVTQWCEGSSLYKHLHVLETNFQMFQLIDIARQTAQGMDYL 455
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIR- 174
+ RK IHRD+KS N+ + + L K+ DFG W V +G++ WMAPEVIR
Sbjct: 456 YMRKHIHRDMKSNNIFLHEGLTVKIGDFGLATVKARWSGSQQVEQPSGSILWMAPEVIRM 515
Query: 175 --HEPCSERVDVWSFGVVLWELLTQEIPYKTL-ETHAILWGVGTETI---LLPVPNSCPE 228
+ P S + DV+S+G+VL+EL+T E+PY + I++ VG + L + CP+
Sbjct: 516 QDNNPYSFQSDVYSYGIVLFELMTGELPYSQIGNRDQIIFMVGRGYLSPDLSKLYKRCPK 575
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++K L+ C + RP F IL+ +++
Sbjct: 576 AMKRLVADCIKKSKDERPLFPQILSSIEL 604
>UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep:
Zgc:153964 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 511
Score = 149 bits (362), Expect = 1e-34
Identities = 90/274 (32%), Positives = 138/274 (50%), Gaps = 14/274 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE-------ETDIMHL 56
S ++WE+P E LGSG VYSG + VA+K L+ + + ++ +
Sbjct: 237 STDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILKNNDALVLREFQLEVQIM 296
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
++L H +++ VC+ + II E + G L FL + G S +I A +A G
Sbjct: 297 KRLRHKHLISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDMAAQVADG 356
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEV 172
M YL IHRDL + NVLV D V K++DFG +R E +S + W APE
Sbjct: 357 MAYLEANNSIHRDLAARNVLVGDGYVCKIADFGLAR-IIKEPVYLSDDKKIPYKWTAPEA 415
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I H S + DVWSFG++L+E++T IPY + T + + E +P P CP+++
Sbjct: 416 IGHGTYSSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDLITKENYRMPSPPKCPQAIY 475
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRV 265
++ CW +RP FK++ LD ++S V
Sbjct: 476 NIMRACWRIESVDRPNFKVLKDELDNYQGQYSSV 509
>UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Rep:
Predicted protein - Ostreococcus lucimarinus CCE9901
Length = 410
Score = 149 bits (362), Expect = 1e-34
Identities = 86/267 (32%), Positives = 147/267 (55%), Gaps = 18/267 (6%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE------ET------DIMH 55
+WE+ + + + SGA G++Y G+ G+ VA+K L+ ET ++
Sbjct: 114 EWELTEKQLVFNEKIASGAFGLLYRGSYCGQEVAIKVLKSNAAEGSGAETLREFAQELNI 173
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGM 115
LR+++H NI++ G ++ + C++ EF G L ++ A P ++IR++ +A G+
Sbjct: 174 LRRVHHKNIIQLIGALTKQKTMCLVTEFMHGGNLLQYVQEHALKLP-ELIRYSLGVAMGL 232
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSF-TGTVAWMAPEVIR 174
YLH IIHRD+K+ N+L+ +N K++DFG +R + + M+ TGT WMAPEVI
Sbjct: 233 DYLHKINIIHRDIKTANLLLDENNAVKIADFGVARIQPTDGSTMTAETGTYRWMAPEVIA 292
Query: 175 HEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H+ +E+ DV+S+G+++WEL++ E+PY GV + + SC + +
Sbjct: 293 HQFYNEKADVYSYGIMVWELVSGGEVPYPGYTPLQAAVGVVQRGLRPTIAPSCHAVIAQV 352
Query: 234 LNQCWDRVPRNRPPFKII---LAHLDI 257
+ CW P RP F+ I L H+D+
Sbjct: 353 MQYCWLVDPNARPGFEQIISLLKHVDV 379
>UniRef50_A0E8G3 Cluster: Chromosome undetermined scaffold_82, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_82,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 1050
Score = 149 bits (360), Expect = 2e-34
Identities = 89/251 (35%), Positives = 137/251 (54%), Gaps = 23/251 (9%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET------------DIMHLRK 58
+ ++ I +G G+ G+V+ GN G+ VA+K ++++ ++ +
Sbjct: 127 INYKEIKQGPQIGKGSYGIVFKGNWLGQGVAIKSYCQRKDQQMHKQLMADFLKEVQVISN 186
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYL 118
L H NIV + GVC + +N+ +I E+ + G L +F QII +DI GM L
Sbjct: 187 LRHPNIVLYMGVCIKQDNFYLITEYMENGSLKT---KNLNFI--QII---EDITLGMNNL 238
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
H RKI+H DLKS NVL+ N K+ DFG S+ ++ +M GT WMAPE++R EP
Sbjct: 239 HGRKIMHCDLKSSNVLIDSNWNVKLCDFGLSKIKSKKTKIM--IGTPHWMAPEIMRGEPY 296
Query: 179 SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC-PESLKLLLNQC 237
+E+ DV+SFG++LWE++T ++PY+ L IL VG + +P S P L ++ C
Sbjct: 297 TEKSDVYSFGLILWEIITGKMPYENLSVTQILGTVGRGHTQVEIPQSSNPPILAIIAKDC 356
Query: 238 WDRVPRNRPPF 248
R P RP F
Sbjct: 357 LKRDPSQRPIF 367
>UniRef50_A2E1W1 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1117
Score = 148 bits (359), Expect = 3e-34
Identities = 85/257 (33%), Positives = 132/257 (51%), Gaps = 13/257 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREKE---------ETDIMH 55
++W + + LGSG VY G + G +V KKL+ ++ + +I
Sbjct: 215 KEWNINPDDFELQKRLGSGTFADVYLGYQKSTGLLVGFKKLKTQQFKFHDFQMYKREIQI 274
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQG 114
L H I+ F G + YC++ EF G L++ L + F + A IA+G
Sbjct: 275 FSSLKHYAILPFVGASIQ-HPYCLVTEFMSNGNLFERLRKATTPFDGTRKTICALGIAEG 333
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR 174
M Y+H++ I+HRDLKS N+L+ + K+ DFG SR + + GT WMAPEV+
Sbjct: 334 MAYMHSKNIMHRDLKSLNILLDSDDFPKICDFGMSRNIEGADVLTGGIGTYRWMAPEVLD 393
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
P + + DV+S+ +VLWELLTQ++P+ L + V + P +CP+ + L+
Sbjct: 394 SRPYTFKADVYSYAIVLWELLTQDVPFHGLSEIQVSMNVIQKDARPLFPQNCPQKIVKLI 453
Query: 235 NQCWDRVPRNRPPFKII 251
+CWDR P RP F+ I
Sbjct: 454 KRCWDRDPDQRPDFETI 470
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 148 bits (359), Expect = 3e-34
Identities = 88/259 (33%), Positives = 135/259 (52%), Gaps = 14/259 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGN-LRGEMVAVKKLRE--KEETDIMH----LRKLNH 61
W + +T + +GSG G+V+ G L + VA+K +RE E D + + KL+H
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSH 415
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+V+ GVC E C++ EF ++G L D+L + F ++ D+ +GM YL
Sbjct: 416 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 475
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+IHRDL + N LV +N V KVSDFG +R + + S TGT V W +PEV
Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSFSR 534
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVWSFGV++WE+ ++ +IPY+ ++ + T L P + ++N
Sbjct: 535 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-GFRLYKPRLASTHVYQIMNH 593
Query: 237 CWDRVPRNRPPFKIILAHL 255
CW P +RP F +L L
Sbjct: 594 CWKERPEDRPAFSRLLRQL 612
>UniRef50_Q94AB2 Cluster: AT3g58640/F14P22_230; n=13;
Magnoliophyta|Rep: AT3g58640/F14P22_230 - Arabidopsis
thaliana (Mouse-ear cress)
Length = 809
Score = 148 bits (358), Expect = 4e-34
Identities = 87/265 (32%), Positives = 139/265 (52%), Gaps = 17/265 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIM 54
L E+W + F +T +G G G V+ G G VA+K E++ T +I
Sbjct: 541 LPYEEWNIDFSELTVGTRVGIGFFGEVFRGIWNGTDVAIKVFLEQDLTAENMEDFCNEIS 600
Query: 55 HLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGAS--FTPRQIIRWAKDI 111
L +L H N++ F G C++ +I E+ + G LY LH SG + R+ ++ +DI
Sbjct: 601 ILSRLRHPNVILFLGACTKPPRLSLITEYMEMGSLYYLLHLSGQKKRLSWRRKLKMLRDI 660
Query: 112 AQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAP 170
+G++ +H I+HRD+KS N L+++ K+ DFG SR + + + GT WMAP
Sbjct: 661 CRGLMCIHRMGIVHRDIKSANCLLSNKWTVKICDFGLSRIMTGTTMRDTVSAGTPEWMAP 720
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
E+IR+EP SE+ D++S GV++WEL T P++ + +++ + E L +P L
Sbjct: 721 ELIRNEPFSEKCDIFSLGVIMWELCTLTRPWEGVPPERVVYAIAYEGARLEIPEG---PL 777
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHL 255
L+ CW P RP IL+ L
Sbjct: 778 GKLIADCWTE-PEQRPSCNEILSRL 801
>UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein
kinase/receptor R831 precursor; n=1; Acanthamoeba
polyphaga mimivirus|Rep: Putative
serine/threonine-protein kinase/receptor R831 precursor -
Mimivirus
Length = 1624
Score = 148 bits (358), Expect = 4e-34
Identities = 88/266 (33%), Positives = 140/266 (52%), Gaps = 14/266 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKK-LREK-EETDIMHLR-------KL 59
W + ++ I+ +G G+ G+V++G +G VAVKK +++K ET ++ R +L
Sbjct: 1357 WIINYDEISIGKQIGLGSYGIVFNGKWKGVDVAVKKFVKQKLSETQLLEFRAEMAFLSEL 1416
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYL 118
H NIV F G C + N CI+ E+ + G L D L + T ++ A G+ YL
Sbjct: 1417 KHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDIKITFANKLKLLYGAAMGIDYL 1476
Query: 119 H--NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHE 176
H N I+HRD+K N+LV ++ K++DFG +R + ++ M+ GT W APEVIR E
Sbjct: 1477 HSSNPMIVHRDIKPANILVDEHFNVKIADFGFARIKE-DNTTMTRCGTPCWTAPEVIRGE 1535
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
E+ DV+SFGVV+WE+LT + P+ + + E +P+ CP L+ +
Sbjct: 1536 KYCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDI-LEGGRPIIPSDCPHEFAKLIKK 1594
Query: 237 CWDRVPRNRPPFKIILAHLDIAGAEF 262
CW RP ++ L + +F
Sbjct: 1595 CWHAKAHKRPTMTEVVQQLMLITEQF 1620
Score = 143 bits (346), Expect = 1e-32
Identities = 96/292 (32%), Positives = 144/292 (49%), Gaps = 27/292 (9%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMH--------- 55
+ DWE+ F + LG+G G VY +G VAVK + K + M
Sbjct: 775 TNNDWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLISSKHVSKDMERSFFEEVKI 834
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQI-IRWAKDIAQ 113
+ L H N+V F ++ N CI+MEF G LYD L + P + I+ A ++
Sbjct: 835 MTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASK 894
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR---EWDNESAVMSFTGTVAWMAP 170
GM +LH+ I+HRDLKS N+L+ KVSDFG ++ E D + + GT+ W+AP
Sbjct: 895 GMHFLHSSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAP 954
Query: 171 EVIRHEPCSERV--DVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
E++ + + DV+SFG++LWELLT+E PYK + AI V + + P+ +
Sbjct: 955 EILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEAVT 1014
Query: 229 SLKL----LLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQAT 276
+ + L+ QCW RP F I+ L S +L D ++T T
Sbjct: 1015 AHSIEYIDLIKQCWHSDTIIRPTFLEIMTRL-------SNILGDSSNMTSGT 1059
>UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein
kinase/receptor R826 precursor; n=2; Acanthamoeba
polyphaga mimivirus|Rep: Putative
serine/threonine-protein kinase/receptor R826 precursor -
Mimivirus
Length = 1657
Score = 148 bits (358), Expect = 4e-34
Identities = 86/250 (34%), Positives = 137/250 (54%), Gaps = 14/250 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKK-LREKEET--------DIMHLRKL 59
W + ++ I +G G+ GVVY G + VA+KK +++K + +I L+KL
Sbjct: 1392 WVINYDEIKMGEQIGLGSYGVVYRGKWKNVDVAIKKFIKQKIDENHLLGIREEIAFLKKL 1451
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVYL 118
+H NI+ G + N CI+ E+ G L D + + Q I+ +IA+G+ YL
Sbjct: 1452 HHPNIITMVGASLKKPNICIVTEYMAKGNLRDAMRTCTPKLEWHQKIKILVNIAKGISYL 1511
Query: 119 HN--RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHE 176
H+ IIHRD+K N+L+ +N K++DFG +R + E+A+M+ GT W APE+IR++
Sbjct: 1512 HSFDPPIIHRDIKPSNILIDENWNVKIADFGFARIKE-ENAIMTRCGTPCWTAPEIIRND 1570
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
E+VDV+SFG+V+WE+LT + P+ I + E + +P CPE L+ +
Sbjct: 1571 IYDEKVDVFSFGIVMWEVLTCKEPFIGANFMKITMDI-LEDVRPKIPQDCPEEFAKLMRK 1629
Query: 237 CWDRVPRNRP 246
CW RP
Sbjct: 1630 CWHAKSTKRP 1639
Score = 128 bits (308), Expect = 4e-28
Identities = 85/270 (31%), Positives = 136/270 (50%), Gaps = 22/270 (8%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE----------ETDIMHL 56
+DWE+ F + LG+GA G V+ G RG VAVK + + + ++ +
Sbjct: 777 DDWEIDFHELELGEQLGTGAFGEVHKGTWRGTEVAVKMISPDKTITKDIERNFKDEVRVM 836
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQI-IRWAKDIAQG 114
L H N+V F ++ CI+MEF G L+D L + P + ++ A ++G
Sbjct: 837 TTLRHPNVVLFMAASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAYQASKG 896
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAV--MSFTGTVAWMAPEV 172
M +LH+ I HRDLKS N+L+ KVSDFG ++ + ++ F GT+ W APE+
Sbjct: 897 MHFLHSSGITHRDLKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQWTAPEI 956
Query: 173 IRHEPCSERV--DVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNS----- 225
+ + + + DV+SFG+++WEL+T++ PY + AI V + + +
Sbjct: 957 LSEDREVDYILSDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVISDQLRSEV 1016
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
PE ++ LL CW P RP F I+ L
Sbjct: 1017 APEYIE-LLTSCWHFDPTIRPTFLEIMTRL 1045
>UniRef50_Q67W58 Cluster: Putative ethylene-inducible CTR1-like
protein kinase; n=3; Oryza sativa|Rep: Putative
ethylene-inducible CTR1-like protein kinase - Oryza
sativa subsp. japonica (Rice)
Length = 1112
Score = 147 bits (357), Expect = 5e-34
Identities = 98/264 (37%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK------EETDIMH---------LRKLN 60
+ ++ LGSG G VY G RG VA+K++ ++ E D M L L+
Sbjct: 838 LEELQELGSGTFGTVYHGKWRGSDVAIKRINDRCFAGKPSEQDKMRNDFWNEASKLADLH 897
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
H N+V F GV +G I + E+ G L L A + R+ + A D A GM Y
Sbjct: 898 HPNVVAFYGVVLDGPGGSIATVTEYMVNGSLRTALLKNAKTLDKRKRLIIAMDTAFGMEY 957
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LHN+ I+H DLKS N+LV + KV D G S+ GT+ WMAPE++
Sbjct: 958 LHNKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELL 1017
Query: 174 RHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+SFG+VLWELLT E PY L I+ G+ + T+ VP+SC +
Sbjct: 1018 NGSSSLVSEKVDVFSFGIVLWELLTGEEPYADLHYGVIIGGIVSNTLRPAVPDSCDPEWR 1077
Query: 232 LLLNQCWDRVPRNRPPFKIILAHL 255
L+ QCW P RP F I L
Sbjct: 1078 SLMEQCWSTEPSERPTFTEIAGRL 1101
>UniRef50_A2DSI0 Cluster: TKL family protein kinase; n=2;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 780
Score = 147 bits (357), Expect = 5e-34
Identities = 89/258 (34%), Positives = 133/258 (51%), Gaps = 13/258 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLR---------EKEETDIMH 55
+ W V + ++ +G G VY G + GE VA+KK + ++ ++
Sbjct: 192 QSWLVDYNDFEEIKEIGRGVSAHVYYGKHKRTGEYVAIKKFTFQKLNSAKFQSDQREVAV 251
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGM 115
L H ++R G ++ +CII E+ G LY +H+ A DIA+GM
Sbjct: 252 LATAQHPALLRLIGA-TDSWPFCIITEWMDGGSLYKAIHTPGHMNATLRTIAAFDIARGM 310
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI-R 174
+LH+RKI+HRDLKS NVL+ N K+ DFG SR + + + S GT WMAPEV+ R
Sbjct: 311 QFLHSRKIVHRDLKSLNVLLDSNKKVKICDFGFSRFAEQSTEMTSNIGTPHWMAPEVLKR 370
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ +VDV+++GV+LWELLT E PY + I+ V +P +++ L+
Sbjct: 371 GSRYTSKVDVYAYGVLLWELLTSETPYDGFGSQQIISEVLNFDARPHLPEQGNMAMRDLI 430
Query: 235 NQCWDRVPRNRPPFKIIL 252
CWDR P RP F I+
Sbjct: 431 TLCWDRDPNTRPNFDDIV 448
>UniRef50_A0DRH3 Cluster: Chromosome undetermined scaffold_60, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_60, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 1233
Score = 147 bits (357), Expect = 5e-34
Identities = 95/276 (34%), Positives = 147/276 (53%), Gaps = 29/276 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE--ETDIMHLRK------ 58
++W + + + +G+G+ VY G RG VA+KK++ K E + R+
Sbjct: 956 QEWMISHDQLRLERLIGTGSSCEVYKGYWRGGEVAIKKMKIKSLNENHLKEFRREISAFV 1015
Query: 59 --LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS----GASFTPRQIIRWAKDIA 112
H+N+V+ G+ + + I+ EFC G L+D LH S+ R I W IA
Sbjct: 1016 TIQKHNNLVQLMGISQKDDELYIVTEFCAGGTLFDLLHRKKHLDISWQNRVKIAW--QIA 1073
Query: 113 QGMVYLH--NRKIIHRDLKSPNVLVADN-----LVAKVSDFGTSR-EWDNESAVMSFTGT 164
+GM++LH N +IHRDLKS N+L+ + K++DFG +R + DN + GT
Sbjct: 1074 EGMLHLHKLNPPLIHRDLKSLNLLLEQTYDQTKVNIKIADFGLARVQADNGEIMTGILGT 1133
Query: 165 VAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETH--AILWGVGTE---TIL 219
WMAPEV ++ P + + DV+S+ +VLWE+ +E PYK L T+ AI+ V + L
Sbjct: 1134 FHWMAPEVFQNVPYTIKADVYSYAIVLWEICCRETPYKQLSTNPPAIMKLVTVDHGRPDL 1193
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
+ CP LK L+ +CWD+ P RP F+ I +L
Sbjct: 1194 NLIQLGCPSFLKDLMIKCWDQDPNKRPSFQEITQYL 1229
>UniRef50_Q4RNI1 Cluster: Chromosome undetermined SCAF15013, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF15013,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 810
Score = 147 bits (356), Expect = 6e-34
Identities = 81/228 (35%), Positives = 130/228 (57%), Gaps = 11/228 (4%)
Query: 142 KVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPY 201
K++DFG +REW +++ MS GT +WMAPEVI+ S+ D+W +GV+LWELLT E+PY
Sbjct: 35 KITDFGLAREW-HKTTKMSAAGTYSWMAPEVIKSSLFSKGSDIWGYGVLLWELLTGEVPY 93
Query: 202 KTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD-IAGA 260
+ ++ A+ +GV + LP+P++CPE L+ +CWD+ P RP F IL L I A
Sbjct: 94 RGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMEECWDQDPHVRPSFSCILEQLSAIEEA 153
Query: 261 EFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQK-----LQSVRREELRLARD 315
+ + D F Q WR EI+ E+ T+ KE + ++ LQ +EEL R+
Sbjct: 154 VMATMPQDSFHSMQDNWRVEIQEMFDELRTKEKELRSREEELTRAALQQKSQEELLKRRE 213
Query: 316 TRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLR 363
+L E+++ + L E+ + QL + + ++ +R+ K R L+
Sbjct: 214 QQLA-EREI---DVLERELNILIFQLNKDKPNVKKRKGKFKRSRLKLK 257
>UniRef50_Q554C0 Cluster: LISK family protein kinase; n=2;
Dictyostelium discoideum|Rep: LISK family protein kinase
- Dictyostelium discoideum AX4
Length = 921
Score = 147 bits (356), Expect = 6e-34
Identities = 90/261 (34%), Positives = 140/261 (53%), Gaps = 19/261 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE------------ETDIMHLR 57
E+ F+ ++ +GSG G VY G L G+ + +KK+ + E +I L+
Sbjct: 20 EIKFDPLS---IIGSGGFGKVYQGVLNGKEIGIKKITISDNDPNRDILLKFLEREIYTLK 76
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL-HSGASFTPRQIIRWAKDIAQGMV 116
L+H N+++F G+ + + ++ E G L+ ++ + T + ++ A+DIA M
Sbjct: 77 MLSHPNVIKFYGIAEKERSLFLLTELVSGGDLHWYIKNKSIDITWKLKVKIARDIAASMA 136
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWD-NESAVMSFTGTVAWMAPEVIRH 175
YLH +IHRDLKS N+LVA+N V KV D G +R+ D +E + M+ GT WMAPEV+
Sbjct: 137 YLHENGVIHRDLKSTNLLVAENWVIKVCDMGLARKMDKSEKSKMTICGTDDWMAPEVLIG 196
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
E DV+SFG+VL EL+T+E + + GV + L VP CP+ L L++
Sbjct: 197 EEYDASCDVFSFGMVLIELITRENLTPRIRNEDL--GVDQKFFLSKVPADCPKELLRLVS 254
Query: 236 QCWDRVPRNRPPFKIILAHLD 256
+C P RP IL L+
Sbjct: 255 ECCKVAPSGRPSASNILGLLE 275
>UniRef50_Q54R58 Cluster: WD-40 repeat-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: WD-40
repeat-containing protein - Dictyostelium discoideum AX4
Length = 918
Score = 147 bits (356), Expect = 6e-34
Identities = 98/268 (36%), Positives = 142/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-----REKEETDIMH-----LRKL 59
E+P +T +G G G VY RG+ VA+KK+ R+ ET+I + KL
Sbjct: 171 EIPSRELTVEKEIGQGFFGKVYKARWRGKSVALKKITLIKFRDLTETEIFDKEVSIMSKL 230
Query: 60 NHDNIVRFRGVCS---EGENYCIIMEFCQYGPLYDFLHSGASF--TPRQIIRWAKDIAQG 114
H V F G CS + IIME+ + G L L +S+ P + A+DIA+G
Sbjct: 231 CHPTCVMFIGACSLDGPSNDRSIIMEYMEGGSLRRLLDEKSSYHLPPSLQLSIARDIAEG 290
Query: 115 MVYLHNR----KIIHRDLKSPNVLVADNL-VAKVSDFGTSREWDNESAVMSFT-GTVAWM 168
M YLH I+HRDL S N+L+ + VAK++DFG S+E M+ G++AWM
Sbjct: 291 MNYLHTNFKEGPIVHRDLTSSNILLNSSYTVAKINDFGLSKEMKPGPTEMTAAMGSLAWM 350
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPE 228
APE + E +E+VDV+SF ++LWE++T PY +E + + E LP+ N P
Sbjct: 351 APECFKAENYTEKVDVYSFAIILWEIVTCRDPYNGMEPLRLAFLASVEDYRLPL-NGFPP 409
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
L+++CW+ P RP FK IL L+
Sbjct: 410 YWVELISKCWNITPSLRPSFKEILQILN 437
>UniRef50_Q4H2W3 Cluster: Serine/threonine protein kinase; n=1;
Ciona intestinalis|Rep: Serine/threonine protein kinase
- Ciona intestinalis (Transparent sea squirt)
Length = 739
Score = 147 bits (356), Expect = 6e-34
Identities = 98/272 (36%), Positives = 138/272 (50%), Gaps = 22/272 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S EDWEVP E I +GSG+ G+VY G +VAVK L T ++
Sbjct: 420 SNEDWEVPEEEIEWGDKIGSGSYGIVYRCRWHG-IVAVKVLNVSNPTPSQLQEFKNEVAV 478
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G + + CI+ ++C LY LH F Q I A+ AQG
Sbjct: 479 LRKTRHVNILLFMGYTIKNQ-LCIVTQWCDGSSLYRHLHMIDTKFDMLQTINIARQTAQG 537
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRD+KS N+ + ++ K+ DFG W +M TG++ WMAPE
Sbjct: 538 MEYLHAKNIIHRDMKSNNIFLLEDYTVKIGDFGLATVKSRWSGSEQLMQPTGSILWMAPE 597
Query: 172 VIR---HEPCSERVDVWSFGVVLWELLTQEIPYKTL-ETHAILWGVGTETI---LLPVPN 224
VIR P + + DV++FGVVL+E+ + +PY + IL+ VG + L + +
Sbjct: 598 VIRMIDGNPYTFQSDVYAFGVVLYEMTSNTLPYSHIGNRDMILFQVGRGYLSPDLDLIRS 657
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P S + L+ C + +RP F I LD
Sbjct: 658 DTPRSCRKLIVDCIKKNREDRPLFPQIWGDLD 689
>UniRef50_Q0GU41 Cluster: TGF beta-activated kinase; n=4;
Eumetazoa|Rep: TGF beta-activated kinase - Paracentrotus
lividus (Common sea urchin)
Length = 717
Score = 147 bits (356), Expect = 6e-34
Identities = 88/251 (35%), Positives = 138/251 (54%), Gaps = 18/251 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEE-----TDIMHLRKLNHDNI 64
EV F I +G GA GVV R VAVK + +EE ++ L +++H NI
Sbjct: 13 EVDFNDILFEKVVGKGAFGVVSKATWRSMNVAVKMIESEEEIKAFRVEVRQLSRVDHPNI 72
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS---FTPRQIIRWAKDIAQGMVYLH-- 119
V+ G C+ + C++MEF + G LY+ LHS + + WA A+G+ YLH
Sbjct: 73 VKLYGACTT-QPVCLVMEFAEGGSLYNVLHSSQPQPIYKAAHAMSWALQCARGVDYLHCM 131
Query: 120 -NRKIIHRDLKSPNVLV-ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
+K+IHRDLK N+L+ + V K+ DFGT+ D + + + G+ AWMAPEV
Sbjct: 132 TPKKLIHRDLKPANLLLMSGGTVLKICDFGTA--CDFHTYMTNNKGSAAWMAPEVFEGRI 189
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHA--ILWGVGTETILLPVPNSCPESLKLLLN 235
SE+ D++S+GV+LWE++++ P+ + A I+W V P+ + P+ L+ L+
Sbjct: 190 YSEKCDIFSWGVILWEVISRRKPFDDIGGPAFRIMWAVHNGK-RPPLIRNIPKPLEKLMT 248
Query: 236 QCWDRVPRNRP 246
+CW + +NRP
Sbjct: 249 RCWAQEAKNRP 259
>UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=51;
Euteleostomi|Rep: Ephrin type-A receptor 7 precursor -
Homo sapiens (Human)
Length = 998
Score = 147 bits (356), Expect = 6e-34
Identities = 95/255 (37%), Positives = 136/255 (53%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNL-----RGEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L R VA+K L+ EK+ D + + + +H N+V
Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G+ I++EF + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLADMGYVHR 757
Query: 127 DLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ AV + TG V W APE I++ +
Sbjct: 758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS 817
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + E LP P CP L L+ CW +
Sbjct: 818 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKE 876
Query: 242 PRNRPPFKIILAHLD 256
RP F+ I+ LD
Sbjct: 877 RAERPKFEQIVGILD 891
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 147 bits (355), Expect = 8e-34
Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 25/275 (9%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM--VAVKKLREKEETD-----IMH- 55
+ ++ W + + + +G G G V+SG LR + VAVK RE + +M
Sbjct: 479 IPKDKWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTPVAVKACRENLPAEHKNKFLMEA 538
Query: 56 ---LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDI 111
L++ +H NIV+ GVC++ + IIME Q G FL + G + +IR A+++
Sbjct: 539 ARILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTEGHNLKSSMLIRMAENV 598
Query: 112 AQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG-----TVA 166
A G+ YL ++K IHRD+ + N LV + V K+SDFG SRE + V S TG V
Sbjct: 599 ASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSRE--EQDGVYSATGGMKQIPVK 656
Query: 167 WMAPEVIRH-EP--CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTET---ILL 220
W APE + + P + DVWSFGV+LWE ++ + T+ T E +
Sbjct: 657 WTAPEALNYGSPGRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYRM 716
Query: 221 PVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
P PN+CP+ + L+ QCW PR RP F + A L
Sbjct: 717 PAPNNCPDEIYTLMCQCWQYDPRKRPSFLKLKADL 751
>UniRef50_Q54IP4 Cluster: SH2 domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: SH2 domain-containing
protein - Dictyostelium discoideum AX4
Length = 653
Score = 147 bits (355), Expect = 8e-34
Identities = 88/244 (36%), Positives = 137/244 (56%), Gaps = 17/244 (6%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLRE---KEET------DIMHLRKLNHDNIVRFRGVCS 72
LGSGA G VY G +RG+ VA+KKL + +E T ++ + KL + +++ F G C+
Sbjct: 180 LGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACT 239
Query: 73 EGENYCIIMEFCQYGPLYDFLHSGAS----FTPRQIIRWAKDIAQGMVYLHNRKIIHRDL 128
E+ I+ E G ++ L + T ++ I A+D GM +LH I+H DL
Sbjct: 240 APEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHASNILHLDL 299
Query: 129 KSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
K N+LV N V KV+DFG S+ D++ ++ G+ +MAPE++ ++P +VDV+S
Sbjct: 300 KPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFS 359
Query: 187 FGVVLWELLTQEIPYKTLETH--AILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
F ++LWELLT++ PY L + ++ GV + +P+ P LK LL +CWD P
Sbjct: 360 FSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSR 419
Query: 245 RPPF 248
RP F
Sbjct: 420 RPSF 423
>UniRef50_Q23AD7 Cluster: Protein kinase domain containing protein;
n=1; Tetrahymena thermophila SB210|Rep: Protein kinase
domain containing protein - Tetrahymena thermophila SB210
Length = 1926
Score = 146 bits (354), Expect = 1e-33
Identities = 95/271 (35%), Positives = 149/271 (54%), Gaps = 26/271 (9%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR--------EKE-ETDIMHLRKLNH 61
V F SIT +GSG G V+SG VA+K++ +KE + +I L K++
Sbjct: 1547 VDFHSITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLNERNQKEFQREIETLVKISP 1606
Query: 62 D-NIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI--IRWAKDIAQGMVYL 118
N+V GV + +N+ II E C G ++D LH S + ++ KDIA GM+YL
Sbjct: 1607 QINLVSLIGVAQKKDNFYIITELCHGGTMFDLLHRKHSVPIPWLHRVKMCKDIATGMIYL 1666
Query: 119 HNRK--IIHRDLKSPNVLV-------ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMA 169
H+ + IIHRDLKS N+L+ + + K++DFG +R +++ + GT WMA
Sbjct: 1667 HSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLART-ESKDEMTQVLGTFHWMA 1725
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGV--GTETILLP--VPNS 225
PEV ++ + + DV+S+ +VLWE ++++ PY+ + T I+ V G L P +P
Sbjct: 1726 PEVFDNKQYTIKADVYSYAIVLWEFISRKTPYQKMSTVDIMKNVCEGKRPGLGPEFIPKD 1785
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
CP SL L+ CW++ P RP F+ +L L+
Sbjct: 1786 CPPSLIDLMKDCWEQDPNKRPDFREVLERLE 1816
Score = 59.7 bits (138), Expect = 2e-07
Identities = 45/155 (29%), Positives = 78/155 (50%), Gaps = 14/155 (9%)
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR--QIIRWAKDIAQGMVYLH 119
D FR + + E +ME C G L S+ + QI+R +DI QG+ YLH
Sbjct: 236 DTKAAFRMILKDTEFGIFVMEHCPKGSLDSICIRLPSYALKEIQIMRIIRDILQGVQYLH 295
Query: 120 NRK--IIHRDLKSPNVLVADNLVAKVSDFG--TSREWDNESAV-----MSFTGTVAWMAP 170
R+ +IHR+L N+L+ ++ K+++F T+ N+ + T + AP
Sbjct: 296 MRQNPLIHRNLTMQNILLGEDNNYKITNFSYVTTHRIQNDDFASLQNEIKKNTTEGYRAP 355
Query: 171 EVIRHE---PCSERVDVWSFGVVLWELLTQEIPYK 202
E I + P +E+VD+++ GV+L+ L + P++
Sbjct: 356 EQIHLQSGYPINEKVDIFAVGVILYILCFNKKPFQ 390
>UniRef50_A2DH69 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 786
Score = 146 bits (354), Expect = 1e-33
Identities = 99/313 (31%), Positives = 159/313 (50%), Gaps = 19/313 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRG--EMVAVKKLREKE---------ETDIMH 55
+ W + + + +GSG VY G L+ E VA+K L+ ++ + ++
Sbjct: 196 QQWRLLYSDLEIEKEIGSGVSSNVYIGILKKTKEKVAIKALKFEQLQGAKLNAFQRELSV 255
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGM 115
L H+ ++RF G ++ +CI+ E+ G LY+ L++ + +P + DIA+GM
Sbjct: 256 LASAQHECLLRFVGA-TDTYPFCIVTEWMPGGSLYNDLNNTGNLSPTERSIAMFDIARGM 314
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI-R 174
LHNR IIHRDLK+ NVL+ N AK+ DFG SR + NE + GT WMAPE++
Sbjct: 315 RCLHNRHIIHRDLKTLNVLIDANNRAKIIDFGLSR-YANEQFMSESIGTPHWMAPELLGS 373
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ +VDV+++ +V WE+L E+PY+ L I+ V + P+ + CP L+ L+
Sbjct: 374 SKQYDLKVDVYAYAIVCWEILMCEVPYEGLLPPQIIARVLINDLRPPLEDDCPPGLRRLI 433
Query: 235 NQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDR-FSVTQATWRKEIENEMKEIYTRNK 293
CW R P RP F I+ A+ +P V + + +I E ++I + K
Sbjct: 434 TSCWQRDPNMRPSFNEIITMF----AKCDIYVPGTDMEVFENYIKTKIAAETEDIDQKMK 489
Query: 294 EKFEQAQKLQSVR 306
E Q L V+
Sbjct: 490 TAVESGQALSIVK 502
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 146 bits (354), Expect = 1e-33
Identities = 87/260 (33%), Positives = 144/260 (55%), Gaps = 14/260 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE----KEE--TDIMHLRKLNH 61
WE+ E IT + LGSG GVV G +G+ VAVK ++E ++E + + KL+H
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH 469
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVYLHN 120
+V+F GVCS+ I+ E+ G L ++L S G P Q++ D+ +GM +L +
Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 529
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
+ IHRDL + N LV +L KVSDFG +R + + +S GT V W APEV +
Sbjct: 530 HQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFK 588
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVW+FG+++WE+ + + PY + ++ V ++ L P+ +++ ++
Sbjct: 589 YSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV-SQGHRLYRPHLASDTIYQIMYS 647
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW +P RP F+ +L+ ++
Sbjct: 648 CWHELPEKRPTFQQLLSSIE 667
>UniRef50_Q9SZM7 Cluster: Protein kinase like protein; n=1;
Arabidopsis thaliana|Rep: Protein kinase like protein -
Arabidopsis thaliana (Mouse-ear cress)
Length = 545
Score = 146 bits (353), Expect = 1e-33
Identities = 75/176 (42%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Query: 31 YSGNLRGEMVAVKKLR--------EKE-ETDIMHLRKLNHDNIVRFRGVCSEGENYCIIM 81
Y G + VA+K L+ EKE ++ +RK+ H N+V+F G C++ + CI+
Sbjct: 293 YKGTYCSQEVAIKVLKPERLDSDLEKEFAQEVFIMRKVRHKNVVQFIGACTKPPHLCIVT 352
Query: 82 EFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLV 140
EF G +YD+LH F + + A DI +GM YLH IIHRDLK+ N+L+ +N V
Sbjct: 353 EFMPGGSVYDYLHKQKGVFKLPTLFKVAIDICKGMSYLHQNNIIHRDLKAANLLMDENEV 412
Query: 141 AKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT 196
KV+DFG +R + + TGT WMAPEVI H+P + DV+S+G+VLWELLT
Sbjct: 413 VKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLT 468
>UniRef50_Q55A09 Cluster: Kelch repeat-containing protein; n=4;
Dictyostelium discoideum|Rep: Kelch repeat-containing
protein - Dictyostelium discoideum AX4
Length = 1331
Score = 146 bits (353), Expect = 1e-33
Identities = 92/252 (36%), Positives = 138/252 (54%), Gaps = 21/252 (8%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKL-----REKEE------TDIMHLRKLNHDNIVRFRGV 70
+G G V GN +G+ VAVKKL + +EE ++ L L H N+V G
Sbjct: 1079 IGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGY 1138
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI-------IRWAKDIAQGMVYLHNRKI 123
CI+MEF G L++ +HS S + I + A DIA+GM +LH R I
Sbjct: 1139 SLNP--MCIVMEFLPSGNLFELIHSKPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRNI 1196
Query: 124 IHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVD 183
IHRDLKS N+L+ + K++D G +RE + + M+ GTVAW APE++RHE +++ D
Sbjct: 1197 IHRDLKSSNLLMDKHFNIKIADLGIARE-TSFTQTMTTIGTVAWTAPEILRHESYNQKAD 1255
Query: 184 VWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPR 243
V+S+ +VL+ELLT E PY+ + V ++ + +P++C + K L+ CW P
Sbjct: 1256 VYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPN 1315
Query: 244 NRPPFKIILAHL 255
RP F+ I +L
Sbjct: 1316 KRPSFEEITNYL 1327
>UniRef50_A2FSI4 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 933
Score = 146 bits (353), Expect = 1e-33
Identities = 95/262 (36%), Positives = 146/262 (55%), Gaps = 20/262 (7%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVY--SGNLRGEMVAVKKL--REKEETDI-MHLRKLN- 60
E++ V E T +G G G V+ + N G+ AVKKL + E ++ +R++
Sbjct: 12 EEYLVKLEDFTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLEGQNLNFFVREVTI 71
Query: 61 ----HDN-IVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GA---SFTPRQIIRWAKD 110
HD ++ F G ++ + I+ EF G L++ LH GA S + + +I A
Sbjct: 72 LASCHDFFLLPFIGF-TDSCPFTIVTEFVPSGSLFEALHHKHGAPTLSASNKTLI--AIG 128
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMA 169
IA GM+ LH + IIHRDLKS N+L+ D L+ K+ DFG SR + M+ GT WMA
Sbjct: 129 IAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQGDDTMTKEIGTPHWMA 188
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
PE+ +E+VDV+++G++LWE+LT+ +P++ + V T+ P+P+SCP +
Sbjct: 189 PEIFESNHYTEKVDVYAYGMILWEMLTESVPFRGRTAIQVATAVVTKNERPPIPSSCPGT 248
Query: 230 LKLLLNQCWDRVPRNRPPFKII 251
L+ L+ CWDR P RP FK I
Sbjct: 249 LRKLIQLCWDRDPEKRPSFKQI 270
>UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=2; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 1071
Score = 145 bits (352), Expect = 2e-33
Identities = 88/268 (32%), Positives = 141/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SGNLR G+ +VA+K L+ E++ D + +
Sbjct: 718 EIDISCVKIEQVIGAGEFGEVCSGNLRQPGKREILVAIKTLKVGYTERQRRDFLSEASIM 777
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ II EF + G L FL FT Q++ + IA G+
Sbjct: 778 GQFDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGV 837
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 838 KYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 897
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + D WS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 898 PEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAI-EQDYRLPPPMDCPS 956
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + NRP F I++ LD
Sbjct: 957 ALHQLMLDCWQKERNNRPKFSQIVSTLD 984
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 145 bits (352), Expect = 2e-33
Identities = 90/266 (33%), Positives = 137/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR----GEM-VAVKKLR----EKEETDIMH----L 56
E+ +I+ +G G G V+ G ++ GE+ VA+K L+ EK+ D + +
Sbjct: 676 EIDPSAISKQKVIGVGEFGEVFRGVMKTRGQGEVNVAIKTLKPGYSEKQRLDFLSEASIM 735
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ ++ I+ E+ G L +L P Q++ + IA GM
Sbjct: 736 GQFSHPNIIHLEGVVTKFKHIMIVTEYMDNGALDTYLKGRDGEIPPYQLVGMLRGIAAGM 795
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL N +HRDL + N+LV NL KVSDFG SR E D+E + G + W APE
Sbjct: 796 QYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDDEGTYTTRGGKIPIRWTAPE 855
Query: 172 VIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + + DVWSFG+V+WE++ E PY + H ++ + E LP P CP ++
Sbjct: 856 AIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAI-NEAFRLPAPMDCPSAI 914
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ QCW RP F I++ LD
Sbjct: 915 YQLMLQCWQHDRSKRPRFSDIVSFLD 940
>UniRef50_Q54Y55 Cluster: SH2 domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: SH2 domain-containing
protein - Dictyostelium discoideum AX4
Length = 506
Score = 145 bits (352), Expect = 2e-33
Identities = 92/263 (34%), Positives = 137/263 (52%), Gaps = 16/263 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRKLN 60
E+ E I +G+G+ G VY G R + VAVK L ++ ++ + K+
Sbjct: 18 EIRPEEINFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIY 77
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI-IRWAKDIAQGMVYLH 119
H NI F G C+ I+ E G L LH P + +R A+D A G+ +LH
Sbjct: 78 HPNICLFMGACTIPGRCVIVTELVPKGNLETLLHDQKIQLPLYLRMRMARDAALGINWLH 137
Query: 120 --NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVM---SFTGTVAWMAPEVIR 174
N +HRD+KS N+LV +N+ K+ DFG S + S GT +MAPEV+
Sbjct: 138 ESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMM 197
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYK-TLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ +E DV+SFG+VLWE+LT++ P+ E V + P+PN C +SL+ L
Sbjct: 198 FKEFNESSDVYSFGIVLWEILTRKEPFSHHRELEKFREAVCVKHERPPIPNDCLDSLRRL 257
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CWD+ P +RP FK I++ LD
Sbjct: 258 IEKCWDKEPISRPSFKEIISALD 280
>UniRef50_A2G0Z0 Cluster: TKL family protein kinase; n=2;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1028
Score = 145 bits (352), Expect = 2e-33
Identities = 91/251 (36%), Positives = 138/251 (54%), Gaps = 21/251 (8%)
Query: 22 LGSGAQGVVYSGNLRGE--MVAVKKLREKEETD---------IMHLRKLNHDNIVRFRGV 70
+GSG V+ G E VA+KK+R +++ D + L L + +++F G
Sbjct: 235 IGSGGFAEVWIGKYIPENLTVAIKKIRPRDDKDKVEQSYMSEVNTLASLRNPFLLQFVGY 294
Query: 71 CSEGENYCIIMEFCQYGPLYDFL---HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
++ E YC++ ++ G LY L + + T QI A IA GM YLH + IIHRD
Sbjct: 295 -TKTEPYCVVTKYMPNGSLYSALRPENESDNLTQTQIAIIAYGIALGMNYLHEKGIIHRD 353
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEPCSERVDV 184
LKS NVL+ DN + DFG+ R N++ + +FTG T +MAPE ++ E E++DV
Sbjct: 354 LKSQNVLLDDNYYPVICDFGSCR---NKNTIRTFTGQGGTANYMAPEFMKAEKYDEKIDV 410
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
+S+G++LWEL+T++ P++ L I+ V +P LK L+ CWDR P+
Sbjct: 411 YSYGILLWELVTKQSPFEGLIPPQIVCTVSMFNRRPDIPPDTNPLLKHLIENCWDRDPKE 470
Query: 245 RPPFKIILAHL 255
RPPF IL +L
Sbjct: 471 RPPFADILKYL 481
>UniRef50_A2FUX6 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 752
Score = 145 bits (352), Expect = 2e-33
Identities = 84/244 (34%), Positives = 127/244 (52%), Gaps = 15/244 (6%)
Query: 22 LGSGAQGVVYSGNLR--GEMVAVKKLR---------EKEETDIMHLRKLNHDNIVRFRGV 70
+G G G V G ++ G +VA+K L E+ +I + L H +++ F G
Sbjct: 209 IGEGISGRVVKGKIKSTGMVVAIKILHLRQLSGADMERFRNEIFAMSTLTHPSLLPFCGY 268
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGMVYLHNRKIIHRDLK 129
E YC+ +F + G L++ L + SF +P A D+A GM +LH+R +IHRDLK
Sbjct: 269 TQEAP-YCLATKFMENGSLFNILSTNPSFLSPTDRTLIAYDVACGMEFLHSRGVIHRDLK 327
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP-CSERVDVWSFG 188
S N+L+ +N K+SDFG R + + GT WMAPE++ P E++D++S+G
Sbjct: 328 SLNILIDENKRGKISDFGFVR-MKSSVPMTGLVGTSHWMAPEILLSSPNYDEKIDIYSYG 386
Query: 189 VVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPF 248
+VLWELLT E PY + V + +P P +K L+ +CW P RP F
Sbjct: 387 IVLWELLTSEKPYANENPATLPLKVIEHNLRPTIPEGTPIKMKTLIERCWSLSPEQRPSF 446
Query: 249 KIIL 252
I+
Sbjct: 447 HDII 450
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 145 bits (351), Expect = 3e-33
Identities = 96/267 (35%), Positives = 140/267 (52%), Gaps = 22/267 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGE-----MVAVKKLR----EKEETDIMH----L 56
E+ +I +G+G G V SG LR + VA+K L+ +K+ D + +
Sbjct: 717 EIDASNIRIERVIGAGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRDFLSEASIM 776
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+ +H NI+R GV + + II EF + G L FL H G FT Q++ + IA G
Sbjct: 777 GQFDHPNIIRLEGVVTRCKPVMIITEFMENGSLDTFLKKHDG-QFTVIQLVGMLRGIASG 835
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAP 170
M YL + +HRDL + N+LV NLV KVSDFG SR E D E+A + G + W AP
Sbjct: 836 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 895
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I + + DVWS+G+V+WE+++ E PY + ++ + E LP P CP
Sbjct: 896 EAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAI-DEGYRLPAPMDCPVV 954
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
L L+ CW++ +RP F I+ LD
Sbjct: 955 LHQLMLDCWEKGRSDRPKFGQIVTILD 981
>UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated
(GTP-bound) p21cdc42Hs; n=1; Ostreococcus tauri|Rep:
Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs - Ostreococcus tauri
Length = 564
Score = 145 bits (351), Expect = 3e-33
Identities = 77/222 (34%), Positives = 124/222 (55%), Gaps = 8/222 (3%)
Query: 52 DIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKD 110
++ LRK+NH+N++ + G EG++ C+I EF G L D++ + F R++ R
Sbjct: 322 EVRILRKINHENVIGYVGSVIEGQDLCLITEFAGNGNLIDYMAAKNRPFGTREVARITLG 381
Query: 111 IAQGMVYLHNR-KIIHRDLKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTGTVAWM 168
IA+GM ++H K++HRDLK+ NVL+ D+L K+ DFG +R N + + TGT WM
Sbjct: 382 IARGMNFIHEGLKMMHRDLKASNVLLDDSLTPKICDFGLARVMAKNPGQMTAETGTYRWM 441
Query: 169 APEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCP 227
APEVI H DV+SF ++ WE+LT ++P+ L V + +P +C
Sbjct: 442 APEVIGHMQYDYSADVYSFAILFWEILTGGQVPFAELNPLQAAVAVVQRGMRPEIPRNCD 501
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDR 269
L ++ +CW P RP F++++A + + VLP+R
Sbjct: 502 PYLVEIMRKCWKTAPSARPTFRVLVAMFE----AYLDVLPER 539
>UniRef50_A2DI38 Cluster: TKL family protein kinase; n=2;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1113
Score = 145 bits (351), Expect = 3e-33
Identities = 97/257 (37%), Positives = 132/257 (51%), Gaps = 17/257 (6%)
Query: 22 LGSGAQGVVY-----SGNLRGEMVAVKKLR---------EKEETDIMHLRKLNHDNIVRF 67
+G GA VY + ++VAVKKL+ E +I K+NH ++ F
Sbjct: 226 IGHGAFADVYWSYQINDKTNNKIVAVKKLKAVHFSQYSFELFYREISIFTKINHPALLPF 285
Query: 68 RGVCSEGENYCIIMEFCQYGPLYDFLHSGASFT-PRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV Y I+ EF + G LY+ LH P ++ A +A M YLH+ KIIHR
Sbjct: 286 VGVTITHPFY-IVTEFMEGGCLYNRLHDREPLRDPTKLTIIAIGVAHAMKYLHSHKIIHR 344
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAPEVIRHEPCSERVDVW 185
DLKS NVL+ N KV DFG SR +MS + GTV WMAPEV+R E SE+ DV+
Sbjct: 345 DLKSLNVLLDANDFPKVCDFGMSRIMPENGEMMSGSVGTVQWMAPEVLRSERYSEKADVY 404
Query: 186 SFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNR 245
SFG++LWELLT + P+K + + V + +P + L L+ CWD P R
Sbjct: 405 SFGILLWELLTGDAPFKQMRDVQVTLAVLSSNARPMMPPNVSTRLAKLIKVCWDSDPDKR 464
Query: 246 PPFKIILAHLDIAGAEF 262
P F+ I L+ +F
Sbjct: 465 PDFETIAKMLESGELDF 481
>UniRef50_A0CTK9 Cluster: Chromosome undetermined scaffold_27, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_27, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 1145
Score = 145 bits (351), Expect = 3e-33
Identities = 90/273 (32%), Positives = 147/273 (53%), Gaps = 25/273 (9%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE--ETDIMHLRK------- 58
+W + + + +G+G+ VY G LRG VA+KK++ ++ E + R+
Sbjct: 869 EWMINHDQLKLETLIGTGSSCTVYKGYLRGGEVAIKKMKIQQLNENHLKEFRREISALVT 928
Query: 59 -LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGM 115
H N+V+ G+ + + I+ E+C G L+D LH + + I+ A IA GM
Sbjct: 929 IKRHQNLVQLLGISQKEDELYIVTEYCAGGTLFDLLHRKKHLEISWQLRIKMAIQIADGM 988
Query: 116 VYLH--NRKIIHRDLKSPNVLVADN-----LVAKVSDFGTSR-EWDNESAVMSFTGTVAW 167
++LH N +IHRDLKS N+L+ + + K++DFG +R + DN + GT W
Sbjct: 989 LHLHKLNPPLIHRDLKSLNLLLEQSYDQNRINIKIADFGLARVQADNGEQMTGVLGTFHW 1048
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETH--AILWGVGTET---ILLPV 222
MAPEV ++ P + + DV+S+ +VLWE+ +E PYK L T+ AI+ V + L +
Sbjct: 1049 MAPEVFQNVPYTIKADVYSYAIVLWEICCRETPYKQLSTNPPAIMKLVAVDNGRPDLSLI 1108
Query: 223 PNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
CP +K L+ +CWD+ P RP F+ + +L
Sbjct: 1109 QVGCPIFMKELMIKCWDKDPTKRPTFQEVSQYL 1141
>UniRef50_A2FNV5 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 775
Score = 144 bits (350), Expect = 3e-33
Identities = 92/242 (38%), Positives = 125/242 (51%), Gaps = 16/242 (6%)
Query: 22 LGSGAQGVVYSGNL--RGEMVAVKKLREKE---------ETDIMHLRKLNHDNIVRFRGV 70
+GSG V+ G+ AVKKL+ KE +I L KLNH + G
Sbjct: 28 IGSGGFSEVFDATFIPTGQRCAVKKLKFKEIKNDEFNLYYREIEVLTKLNHPYCLNLIGF 87
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTP---RQIIRWAKDIAQGMVYLHNRKIIHRD 127
S + I+ E Q G LYD L P Q A IA GM LH IIHRD
Sbjct: 88 -SVHRPFIIVTELLQRGSLYDALRWKDPEKPLNGSQKTIIAMCIASGMERLHKLNIIHRD 146
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAPEVIRHEPCSERVDVWS 186
LKS N+L+ ++ + ++ DFG SRE A+M+ GT WMAPE+ +P S +VDV+S
Sbjct: 147 LKSLNILLDNDKLPRIIDFGLSREVSESDAIMTMQIGTPHWMAPELFSSQPYSFKVDVYS 206
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
+G++LWE+LT P+K I++ V + +PN CP SLK ++N CW + P RP
Sbjct: 207 YGMLLWEMLTNSSPFKGKTAAQIMYEVVEKGARPAIPNRCPSSLKAMINACWAQDPEQRP 266
Query: 247 PF 248
F
Sbjct: 267 TF 268
>UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=22;
Euteleostomi|Rep: Ephrin type-A receptor 8 precursor -
Homo sapiens (Human)
Length = 1005
Score = 144 bits (350), Expect = 3e-33
Identities = 97/255 (38%), Positives = 132/255 (51%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+GSG G V G LR G+ VA+K L+ E++ D + + + +H NI+R
Sbjct: 641 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE 700
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + G I+ E+ + G L FL H G FT Q++ + + GM YL + +HR
Sbjct: 701 GVVTRGRLAMIVTEYMENGSLDTFLRTHDG-QFTIMQLVGMLRGVGAGMRYLSDLGYVHR 759
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + NVLV NLV KVSDFG SR D+ A + TG + W APE I S
Sbjct: 760 DLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS 819
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWSFGVV+WE+L E PY + ++ V E LP P CP +L L+ CW +
Sbjct: 820 DVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLDCWHKD 878
Query: 242 PRNRPPFKIILAHLD 256
RP F I++ LD
Sbjct: 879 RAQRPRFSQIVSVLD 893
>UniRef50_Q4SPJ8 Cluster: Chromosome 16 SCAF14537, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 16 SCAF14537, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 835
Score = 144 bits (349), Expect = 4e-33
Identities = 80/227 (35%), Positives = 131/227 (57%), Gaps = 11/227 (4%)
Query: 142 KVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPY 201
K++DFG +REW +++ MS GT AWMAPEVI+ S+ DVWSFGV+LWELLT E+PY
Sbjct: 80 KITDFGLAREW-HQTTKMSAAGTYAWMAPEVIKLSLFSKSSDVWSFGVLLWELLTGEVPY 138
Query: 202 KTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAH-LDIAGA 260
+ ++ A+ +GV + LP+P++CPE+ LL +CW P +RP F IL L I +
Sbjct: 139 REIDALAVAYGVAMNKLTLPIPSTCPEAFAQLLEECWSPNPHSRPSFTSILRRLLAIEQS 198
Query: 261 EFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKE--KFEQ--AQKLQSVRREELRLARDT 316
++ + F Q WR EI+ E+ + KE +E+ A+ + R +E +L R
Sbjct: 199 AMFQMPLESFHSLQEDWRLEIQQMFDELRAKEKELRSWEEALARAAEEQREQEEQLRRRE 258
Query: 317 RLIYEQQLS----RANELYMEVCAVRLQLEQKEKHLDEREKALKLCR 359
+ + E+++ N + +V + +++++ H ++ + LKL R
Sbjct: 259 QELAEREIDIVERELNIIIHQVYQEKPSVKKRKGHF-KKSRLLKLGR 304
>UniRef50_Q9STG4 Cluster: Putative uncharacterized protein T6H20.50;
n=1; Arabidopsis thaliana|Rep: Putative uncharacterized
protein T6H20.50 - Arabidopsis thaliana (Mouse-ear cress)
Length = 1171
Score = 144 bits (349), Expect = 4e-33
Identities = 98/266 (36%), Positives = 137/266 (51%), Gaps = 28/266 (10%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK--------EE-------TDIMHLRKLN 60
+ ++ LGSG G VY G RG VA+K++ ++ +E + +L L+
Sbjct: 888 LEELRELGSGTFGTVYHGKWRGTDVAIKRINDRCFAGKPSEQERMIDDFWNEAQNLAGLH 947
Query: 61 HDNIVRFRGVC--SEGENYCIIMEFCQYGPLYDFLHSGA-SFT--PRQIIRWAKDIAQGM 115
H N+V F GV S G + + E+ G L + L +F RQ+I A DIA GM
Sbjct: 948 HPNVVAFYGVVLDSPGGSVATVTEYMVNGSLRNALQKNVRNFDRCKRQLI--AMDIAFGM 1005
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH +KI+H DLKS N+LV + KV D G S+ GT+ WMAPE
Sbjct: 1006 EYLHGKKIVHFDLKSDNLLVNLRDPHRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPE 1065
Query: 172 VIRHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ SE+VDV+SFG+VLWEL T E PY L AI+ G+ + T+ +P+ C
Sbjct: 1066 LLNGTSSLVSEKVDVFSFGIVLWELFTGEEPYADLHYGAIIGGIVSNTLRPQIPDFCDMD 1125
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
KLL+ +CW P RP F I+ L
Sbjct: 1126 WKLLMERCWSAEPSERPSFTEIVNEL 1151
>UniRef50_A2DAP2 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 995
Score = 144 bits (349), Expect = 4e-33
Identities = 87/247 (35%), Positives = 133/247 (53%), Gaps = 14/247 (5%)
Query: 22 LGSGAQGVVYSGNLR--GEMVAVKKLREKE---------ETDIMHLRKLNHDNIVRFRGV 70
+G+G G VY G + GE VAVK L +K+ + ++ L L H I++F G
Sbjct: 209 IGTGVSGNVYLGKNKNTGEEVAVKILHKKQLSGSELESYQREVYALSVLVHPCILKFCGY 268
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGMVYLHNRKIIHRDLK 129
+E Y I+ E+ G L+D L TP A DIA+G+ YLH++ +IHRD+K
Sbjct: 269 -TEDPPYYILTEYMANGCLFDILRKRPQILTPTIRSLIALDIARGLEYLHSKGVIHRDMK 327
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP-CSERVDVWSFG 188
S N+L+ +N A++ DFG R + + + GT WMAPEV+ P E+VDV+S+
Sbjct: 328 SLNILIDNNYRARICDFGFVRSKNQATPMTGLIGTAHWMAPEVLLSSPNYDEKVDVYSYA 387
Query: 189 VVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPF 248
++LWELLT E P+ + I V + P+P++ P +L L+N+CW P R
Sbjct: 388 ILLWELLTNEPPFSGMNPSQITDLVINQGYRPPIPDNAPPNLTKLINKCWQTDPTKRLSM 447
Query: 249 KIILAHL 255
++ +L
Sbjct: 448 SKVVRYL 454
>UniRef50_UPI0000D572D6 Cluster: PREDICTED: similar to CG2845-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG2845-PA - Tribolium castaneum
Length = 704
Score = 144 bits (348), Expect = 6e-33
Identities = 96/272 (35%), Positives = 139/272 (51%), Gaps = 22/272 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S EDWE+P + I +GSG+ G VY + G VAVK L K T ++
Sbjct: 380 SIEDWEIPADEILVGHRVGSGSFGTVYKAHWHGP-VAVKTLNVKIPTLAQLQAFKNEVAV 438
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQG 114
LRK H NI+ F G C I+ ++C+ LY LH F +I + AQG
Sbjct: 439 LRKTRHVNILLFMG-CVSKPQLAIVTQWCESSSLYKHLHVHETKFALFTLIEIGRQTAQG 497
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR---EWDNESAVMSFTGTVAWMAPE 171
M YLH + IIHRDLKS N+ + D+L K+ DFG + W TG++ WMAPE
Sbjct: 498 MDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATAKIRWSGSKQFHQPTGSILWMAPE 557
Query: 172 VIRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLET-HAILWGVGTETI---LLPVPN 224
VIR + P S + DV++FG+V++E+L ++PY + IL+ VG + + + +
Sbjct: 558 VIRMQEDNPYSFQSDVYAFGIVMFEMLAMQLPYSHINNKDQILFMVGRGYLKPDMSKLRS 617
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P++L+ L C RP F+ I A L+
Sbjct: 618 DTPKALRRLTEDCIKFNRDERPLFRQIHASLE 649
>UniRef50_UPI000049A3B4 Cluster: protein kinase; n=1; Entamoeba
histolytica HM-1:IMSS|Rep: protein kinase - Entamoeba
histolytica HM-1:IMSS
Length = 670
Score = 144 bits (348), Expect = 6e-33
Identities = 85/259 (32%), Positives = 140/259 (54%), Gaps = 14/259 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETD---------IMHLR 57
ED+ P E + D++ LG G G V+ RG+ VAVK + + D + ++
Sbjct: 396 EDFINPNEVVCDII-LGKGTFGNVWRATWRGQSVAVKLIPTRMVIDNTILQFTKEVQLMK 454
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASF-TPRQIIRWAKDIAQGMV 116
L H +++ G ++ I+ME + G + L + + T ++ ++ D A GM
Sbjct: 455 HLRHPCVLQLFGSGTDMNYILIVMELMERGSVRSILADKSIYLTWKRRLKMLHDAASGMY 514
Query: 117 YLHNR--KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFT-GTVAWMAPEVI 173
YLH++ IIHRDLKS N+LV KVSDFG S +N + + GT++W+APE++
Sbjct: 515 YLHSKIPPIIHRDLKSSNLLVDSLWRVKVSDFGLSISLNNNETIKTTVCGTLSWIAPEIL 574
Query: 174 RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+P ++VDV+SFG+++WE LT++IPYK + +I V + +P + L
Sbjct: 575 ARKPYCQKVDVYSFGIIMWEFLTRDIPYKNIPLKSISDYVVNAHLRPKIPENVDLMYSSL 634
Query: 234 LNQCWDRVPRNRPPFKIIL 252
+ +CW+ P NRP FK ++
Sbjct: 635 MARCWNEQPSNRPDFKEVV 653
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 144 bits (348), Expect = 6e-33
Identities = 90/265 (33%), Positives = 141/265 (53%), Gaps = 17/265 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--------EETDIMHL 56
++ WE+ +SI + LG+G G V+ VAVK L+ EE ++M
Sbjct: 235 KDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLM-- 292
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQG 114
+ L HD +VR V ++ E II E+ G L DFL S G+ ++I ++ IA+G
Sbjct: 293 KTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEG 352
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEV 172
M Y+ + IHRDL++ NVLV++ L+ K++DFG +R E D +A + W APE
Sbjct: 353 MAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEA 412
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I + + + D+WSFGV+L+E++T +IPY + ++ V +P P +CP L
Sbjct: 413 INYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSV-QRGYRMPRPENCPVELY 471
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW P +RP F I + LD
Sbjct: 472 EIMTTCWKNKPEDRPTFDYIQSVLD 496
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 144 bits (348), Expect = 6e-33
Identities = 85/269 (31%), Positives = 145/269 (53%), Gaps = 18/269 (6%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDIMHLR 57
++++WE+P + LG G G V+ G RG + VA+K ++ E + ++
Sbjct: 251 TQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMK 310
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMV 116
+ +H N+V+ VC+ E + II E+ G L +L + G++ + ++ A IA GM+
Sbjct: 311 QCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQALVDMAAQIANGMM 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNL----VAKVSDFGTSREWDNESAVMSFTGT---VAWMA 169
YL RK++HRDL + NVLV D + V KV+DFG +R+ E + TG + W A
Sbjct: 371 YLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTA 430
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE + + DVWS+G++L+E++T+ ++PY + ++ V +P+P CPE
Sbjct: 431 PEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVEL-GYRMPMPRGCPE 489
Query: 229 SL-KLLLNQCWDRVPRNRPPFKIILAHLD 256
+ + +L +CWD+ P RP F + D
Sbjct: 490 QIYEEVLLKCWDKTPDRRPTFDTLYHFFD 518
>UniRef50_Q55GE6 Cluster: WD40 repeat-containing protein; n=2;
Dictyostelium discoideum|Rep: WD40 repeat-containing
protein - Dictyostelium discoideum AX4
Length = 2615
Score = 144 bits (348), Expect = 6e-33
Identities = 90/276 (32%), Positives = 147/276 (53%), Gaps = 25/276 (9%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-----------REKEETDIMHLR-K 58
+P+E++ LGSG+ VY G G VA+K L + +E + H+ +
Sbjct: 1770 IPYETLKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTTEKYREFRNEAHITGE 1829
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
L H N V GV +C++ E QYG L F+ + A +F+ +++ A D+A+GM +
Sbjct: 1830 LRHANTVSLMGVSLSP--FCLVTELLQYGDLAKFIRNTAETFSWGTVLKLAIDVAKGMNF 1887
Query: 118 LHNRK--IIHRDLKSPNVLVA----DNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
LH+ K I+HRDLKS N+L+ DNLVAKV DFG S + + W+APE
Sbjct: 1888 LHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSIKPIGKEVKGRKVWNWRWLAPE 1947
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEIPYK----TLETHAILWGVGTETILLPVPNSCP 227
+ +E++D++S+ +VLWE++T+++P++ L+ ++I+ + + +PN CP
Sbjct: 1948 CMGDGQYTEKIDIYSYAIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECP 2007
Query: 228 ESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFS 263
+K L+ CW P+ RP F IL L F+
Sbjct: 2008 PDMKQLITDCWSGDPKKRPSFNSILERLSTMQKTFN 2043
>UniRef50_Q23K41 Cluster: Protein kinase domain containing protein;
n=1; Tetrahymena thermophila SB210|Rep: Protein kinase
domain containing protein - Tetrahymena thermophila SB210
Length = 1583
Score = 144 bits (348), Expect = 6e-33
Identities = 93/278 (33%), Positives = 147/278 (52%), Gaps = 30/278 (10%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKL-------- 59
D+ V F I +GSG VY G + + VA+K ++ + +D +HL++
Sbjct: 1297 DFIVDFSEIKMGNKIGSGNSCEVYKGRCKNKDVAIKVIK-LDNSDELHLKEFQREIQALI 1355
Query: 60 ---NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR----QIIRWAKDIA 112
NH+N+++ + S N+ II EFC+ G L++ LH IRW KD+A
Sbjct: 1356 KLKNHENLLQLVAISSYDNNFYIITEFCEGGTLFELLHKKKQQIKMIKWDHRIRWLKDLA 1415
Query: 113 QGMVYLHNRKIIHRDLKSPNVLV-------ADNL-VAKVSDFGTSREWDNESAVMSF--T 162
+GM+YLH +IHRDLKS N+L +DN+ K++DFG +R +++
Sbjct: 1416 KGMLYLHQNNLIHRDLKSLNLLFDKPYDPNSDNIPTMKIADFGLTRVGSSQAVPFQSGAL 1475
Query: 163 GTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTL-ETHAILWGVGTE---TI 218
GT WMAPE +R++P S + DV+SF +V++EL ++E P+K AI+ V E
Sbjct: 1476 GTFHWMAPETMRNQPVSTQADVYSFAIVMYELASRETPFKEKGNVAAIIKYVSEEKGRPN 1535
Query: 219 LLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
L + P+ + L+ +CWD P+ RP F I+ L+
Sbjct: 1536 LQKLHFDTPQFIIKLMIKCWDENPKKRPKFDQIIQVLE 1573
Score = 63.7 bits (148), Expect = 1e-08
Identities = 43/163 (26%), Positives = 81/163 (49%), Gaps = 19/163 (11%)
Query: 61 HDNIVRFRGV--CSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMV 116
H NIV++ G G +++E C G L D + + +QI+R ++AQG+
Sbjct: 70 HSNIVQYLGSQELQGGSLGVLVIENCPKGSLVDIMSMTPKNQLSEQQILRVIYEVAQGLS 129
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE----------WDNESAVMSFTGTVA 166
++H RK+IHRD+K N+L ++ K+ DFG+ + M T
Sbjct: 130 HIHKRKLIHRDIKIENILYSEENRFKICDFGSVTNNLVPKISKCNIQDIKEEMDRNTTPM 189
Query: 167 WMAPEVIRHE-----PCSERVDVWSFGVVLWELLTQEIPYKTL 204
+ APE++ P +E++D+++ GV+ + L ++ P+ ++
Sbjct: 190 YRAPEILDPHIFPDYPINEKIDIFALGVLAYILCFKKPPFDSI 232
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 144 bits (348), Expect = 6e-33
Identities = 87/260 (33%), Positives = 136/260 (52%), Gaps = 15/260 (5%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMH-------LRKLN 60
+WE+ I +GSG G V+ G RG+ VA+K L++ + I + +L
Sbjct: 207 NWEISPREIVKSAQIGSGQFGDVFEGLYRGQKVAIKTLKDVQGDAIDQFLLEADTMTRLR 266
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG--ASFTPRQIIRWAKDIAQGMVYL 118
H N+V+ GVC++G I+ EF G L D+L S A + + +DI M YL
Sbjct: 267 HKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGFCRDICAAMEYL 326
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG-TVAWMAPEVIRHEP 177
+K +HRDL + N+L++D+ VAKV+DFG ++ D++ V + W APE IR +
Sbjct: 327 EEQKFVHRDLAARNILLSDDGVAKVADFGLAK--DSQLGVTDIGKLPIKWTAPEAIRLKV 384
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCP-ESLKLLLN 235
+ + DVWSFGVVLWE+ PY + ++ V + + P++CP E ++
Sbjct: 385 STSKSDVWSFGVVLWEIFAFGRAPYPRMGQKEVVDAV-VKGYRMECPDTCPKEVYDKIMM 443
Query: 236 QCWDRVPRNRPPFKIILAHL 255
CW+ P RP FK ++ L
Sbjct: 444 ACWEIDPVKRPTFKTLMRAL 463
>UniRef50_Q9V3Q6 Cluster: Mitogen-activated protein kinase kinase
kinase 7; n=6; Sophophora|Rep: Mitogen-activated protein
kinase kinase kinase 7 - Drosophila melanogaster (Fruit
fly)
Length = 678
Score = 144 bits (348), Expect = 6e-33
Identities = 82/254 (32%), Positives = 143/254 (56%), Gaps = 15/254 (5%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL----REKE-ETDIMHLRKLNHDNIV 65
V F IT +G G+ GVV R ++VAVK+ +K+ E ++ L ++ H NI+
Sbjct: 14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNII 73
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA--SFTPRQIIRWAKDIAQGMVYLHN--- 120
G+ S + +IMEF + G L++FLH +++ + WA+ A+G+ YLH
Sbjct: 74 ALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTP 133
Query: 121 RKIIHRDLKSPNVLVADN-LVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCS 179
+ +IHRD+K N+L+ + K+ DFGT D + + + G+ AWMAPEV +
Sbjct: 134 KPLIHRDVKPLNLLLTNKGRNLKICDFGTVA--DKSTMMTNNRGSAAWMAPEVFEGSKYT 191
Query: 180 ERVDVWSFGVVLWELLTQEIPYKTLE-THAILWGVGTETILLPVPNSCPESLKLLLNQCW 238
E+ D++S+ +VLWE+L+++ P+K ++ + I W + + P+ +CP+ ++ L+ CW
Sbjct: 192 EKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKI-YKGERPPLLTTCPKRIEDLMTACW 250
Query: 239 DRVPRNRPPFKIIL 252
VP +RP + I+
Sbjct: 251 KTVPEDRPSMQYIV 264
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 144 bits (348), Expect = 6e-33
Identities = 91/267 (34%), Positives = 134/267 (50%), Gaps = 18/267 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREK--EETDIMHL------ 56
++ W + E + LG G G VY G L+ + VAVK +E +E I L
Sbjct: 553 DKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKIL 612
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGM 115
++ +H NIV+ GVC++ + IIME G FL +Q+++++ D A GM
Sbjct: 613 KQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGM 672
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG----TVAWMAPE 171
+YL ++ IHRDL + N LV +N V K+SDFG SR+ D V S +G + W APE
Sbjct: 673 LYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPE 730
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + S DVWSFG++LWE + + PY + V + P CPE +
Sbjct: 731 ALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV-ERGYRMSAPQHCPEDI 789
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLDI 257
++ +CWD P NRP F + L I
Sbjct: 790 SKIMMKCWDYKPENRPKFSELQKELTI 816
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 143 bits (347), Expect = 8e-33
Identities = 89/267 (33%), Positives = 140/267 (52%), Gaps = 23/267 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR----GEM-VAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SGNL+ EM VA+K L+ EK+ D + +
Sbjct: 636 EIDISCVKIEQVIGAGEFGEVCSGNLKLPGKREMFVAIKTLKTGYTEKQRRDFLSEASIM 695
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMV 116
+ +H N++ GV ++ II EF + G L FL S Q++ + IA GM
Sbjct: 696 GQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDAFLR--VSIHGDQLVGMLRGIASGMK 753
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAP 170
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W AP
Sbjct: 754 YLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAP 813
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP +
Sbjct: 814 EAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPST 872
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLD 256
L L+ CW + NRP F I+ +LD
Sbjct: 873 LHQLMLDCWQKDRNNRPKFSQIVNNLD 899
>UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10323,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 815
Score = 143 bits (347), Expect = 8e-33
Identities = 94/250 (37%), Positives = 135/250 (54%), Gaps = 20/250 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ SI+ +G+G G V SG LR G+ +VA+K L+ E++ D + +
Sbjct: 472 EIHLSSISIERIIGAGEFGEVCSGPLRLPGKREILVAIKTLKAGYTEQQRRDFLWEASIM 531
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ NH NI+R GV ++ + II E+ + G L FL FT Q++ + IA GM
Sbjct: 532 GQFNHPNIIRLEGVVTKSKPVMIITEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGM 591
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+LV +LV KVSDFG SR E D E+A + G + W APE
Sbjct: 592 RYLSDMGYVHRDLAARNILVDGHLVCKVSDFGLSRALEDDPEAAYTTQGGKIPIRWTAPE 651
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + + DVWS+GVV+WE+++ E PY + ++ V E LP P CPESL
Sbjct: 652 AIAYRKFTSASDVWSYGVVMWEVMSYGERPYWDMSNQDVIKAV-EENYRLPGPMDCPESL 710
Query: 231 KLLLNQCWDR 240
L+ CW R
Sbjct: 711 YQLMTDCWQR 720
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 143 bits (346), Expect = 1e-32
Identities = 73/207 (35%), Positives = 120/207 (57%), Gaps = 9/207 (4%)
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQ-YGPLYDFLHS-GASFTPRQIIRWAKDIAQ 113
L++ +H N+V+ GVC++ + I+ME Q G FL + G P+ +++ A+++A
Sbjct: 711 LKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSGDFLTFLRNQGRDLKPKALVKMAENVAS 770
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG----TVAWMA 169
GM YL ++K IHRDL + N LVA+N K+SDFG SR+ D++ ++ G + W A
Sbjct: 771 GMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQ-DDDGVYLAEGGLRQIPIKWTA 829
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPE 228
PE + + + + DVWSFG++LWE + + PY ++ V + +P P++CP
Sbjct: 830 PEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEV-EKGYRMPAPHACPV 888
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHL 255
+ ++N CW P+NRP FK + A L
Sbjct: 889 EIARIMNNCWQYDPQNRPSFKKLRAEL 915
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 143 bits (346), Expect = 1e-32
Identities = 84/260 (32%), Positives = 133/260 (51%), Gaps = 11/260 (4%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLRE-----KEETDIMHLRKLN 60
++ W +P + +G G G V G LR E VAVK L++ K + + L
Sbjct: 585 DKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASVMTTLE 644
Query: 61 HDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVYL 118
HDN+V+F G+ ++ ++ E+ G L D+L S T + I +A D A GM YL
Sbjct: 645 HDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYL 704
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
+K++HRDL + NVL++++ VAKVSDFG +RE V + W APE +++
Sbjct: 705 EAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDVGKL--PIKWTAPEALKNGRF 762
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+WSFG++LWE+ + +PY + ++ V + P CP + ++ Q
Sbjct: 763 SNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEV-GYKMEAPEGCPPEIYEMMRQA 821
Query: 238 WDRVPRNRPPFKIILAHLDI 257
WD P RP F + L +
Sbjct: 822 WDLNPAKRPTFAELKVKLQL 841
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 143 bits (346), Expect = 1e-32
Identities = 93/266 (34%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEETDIMH-------- 55
++ W + E + +G G G V+SG LR + +VAVK RE D+
Sbjct: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQG 114
L++ +H NIVR GVC++ + I+ME Q G FL + GA + +++ D A G
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT----VAWMAP 170
M YL ++ IHRDL + N LV + V K+SDFG SRE + + + G+ V W AP
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGSRQVPVKWTAP 659
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
E + + S DVWSFG++LWE + PY L V + LP P CP++
Sbjct: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV-EKGGRLPCPELCPDA 718
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ L+ QCW P RP F I L
Sbjct: 719 VFRLMEQCWAYEPGQRPSFSTIYQEL 744
>UniRef50_UPI0000498D53 Cluster: protein kinase; n=1; Entamoeba
histolytica HM-1:IMSS|Rep: protein kinase - Entamoeba
histolytica HM-1:IMSS
Length = 596
Score = 142 bits (345), Expect = 1e-32
Identities = 86/249 (34%), Positives = 136/249 (54%), Gaps = 18/249 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVK---------KLREKEETDIMHLRKLNHDNIVRFRGVCS 72
+G G+ G V+S + +G+ +AVK K E+ ++ ++ L H I++F G
Sbjct: 335 IGRGSFGDVWSASWKGQEIAVKLIPIERVEKKNIEEVTKEVKLMKSLRHPCILQFFGSGM 394
Query: 73 EGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVYLHNRK--IIHRDLK 129
+ I ME Q G + + L++ + T +R KD A GM YLH+ K I+HRDLK
Sbjct: 395 DNNFMLIAMELMQNGTVREILNNSCINLTIENKLRMLKDTASGMFYLHHCKPPILHRDLK 454
Query: 130 SPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFG 188
+ N+LV DN KVSDFG S E + GT+AW+APE+++++P + DV+SFG
Sbjct: 455 TNNLLVNDNWCVKVSDFGLSTPLLGKEINTTNLCGTLAWIAPEILQNKPFGIKSDVYSFG 514
Query: 189 VVLWELLTQEIPYKTLETHAILWGVGTETILLPVP-----NSCPESLKLLLNQCWDRVPR 243
+V+WE+LT++ PY L + I+ V + +P N + L+ +CWD +P
Sbjct: 515 IVMWEILTRKRPYSKLTPYQIMLSVSQKGSRPKIPKKLATNEINKKYIELMERCWDELPE 574
Query: 244 NRPPFKIIL 252
+RP F I+
Sbjct: 575 SRPLFDEII 583
>UniRef50_Q55AN7 Cluster: SMAD/FHA domain-containing protein; n=2;
Dictyostelium discoideum|Rep: SMAD/FHA domain-containing
protein - Dictyostelium discoideum AX4
Length = 1024
Score = 142 bits (345), Expect = 1e-32
Identities = 94/251 (37%), Positives = 134/251 (53%), Gaps = 23/251 (9%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKL---------REKEETDIMHLRKLNHDNIVRFRGVCS 72
+GSGA G V +G VAVK + +E+ E ++ L+ L H N+V F G C
Sbjct: 366 IGSGACGEVCQYEWKGTPVAVKTIFKSLLRKDKKEEFEKEVSILKCLRHPNVVLFMGTCL 425
Query: 73 EGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVYLHNRK--IIHRDL 128
N II E+ G L D L + + + ++ D+AQGM YLH IIHRDL
Sbjct: 426 LNGNLAIITEYLNRGSLRDVLTTMNKSELSLSVKVKMLIDVAQGMNYLHTYSPPIIHRDL 485
Query: 129 KSPNVLVADNLVAKVSDFGTSREWDNE--SAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
KS N+LV +N KVSDFG SR S+ +F GT++W+APEV + +VDV+S
Sbjct: 486 KSLNLLVDNNFNVKVSDFGLSRFISGGIGSSAKTFCGTLSWIAPEVFNGSGYTTKVDVYS 545
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
FG+VLWE+LT + P + ++ G + P++CP+S L+ +C +R P RP
Sbjct: 546 FGIVLWEILTHKQPSGNISATSL----GHPEL----PSNCPQSFSDLIKECCNRNPDQRP 597
Query: 247 PFKIILAHLDI 257
F IL L +
Sbjct: 598 NFSQILLKLKL 608
Score = 44.0 bits (99), Expect = 0.009
Identities = 37/135 (27%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 132 NVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
N L + + KV DFG SR +NE ++ G + PE++ S + D++S +
Sbjct: 882 NELNINEIKIKVHDFGLSRFNTQENEESLKEIKGNFLYSPPELLSLNTYSNKSDIYSLSI 941
Query: 190 VLWELL------TQEIPYK--TLETHAILWGVGTETILLP-VPNSCPESLKLLLNQCWDR 240
VL+EL T + PY TL+ + ++ L P + N+ P + +L Q W
Sbjct: 942 VLYELFETCLTKTYKKPYHEVTLDFDFQIIHKTSKLNLRPTISNNMPNEISKILQQGWFS 1001
Query: 241 VPRNRPPFKIILAHL 255
RP I+ L
Sbjct: 1002 DSVLRPSLDTIIKEL 1016
>UniRef50_A2FUJ1 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1085
Score = 142 bits (345), Expect = 1e-32
Identities = 84/257 (32%), Positives = 133/257 (51%), Gaps = 16/257 (6%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKEET---------DIMHLRKL 59
+P E I +G+G G V+ GE+VAVK+LR T ++ + +
Sbjct: 216 IPLEDIRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTMSSWASLYAEVETMASV 275
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH----SGASFTPRQIIRWAKDIAQGM 115
H ++ G + Y II FC L+D LH +G T ++ + A +A GM
Sbjct: 276 RHQFVLELVGAHIT-QPYRIITRFCPGKSLFDRLHRLGPNGVPLTANELTKIAYQVALGM 334
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRH 175
+LH+ I+HRDLK+ N+L+ + V+DFG S + ++ GT + APEV+ H
Sbjct: 335 SHLHSMNIVHRDLKTLNILLDEYNDGFVADFGLSGIMKDNQELVGGVGTPHYTAPEVLMH 394
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
+VD +S+GVVLWE+L +++PY + I V T LP+PN P+ +K L+
Sbjct: 395 SRYGPKVDTFSYGVVLWEMLMRKVPYAEMSQVQIYEHVVTRGWRLPIPNDTPDGMKKLIT 454
Query: 236 QCWDRVPRNRPPFKIIL 252
+CW++ P +RP F I+
Sbjct: 455 RCWNKNPNDRPNFDEII 471
>UniRef50_A7NXT1 Cluster: Chromosome chr5 scaffold_2, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr5 scaffold_2, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 1106
Score = 142 bits (344), Expect = 2e-32
Identities = 93/266 (34%), Positives = 131/266 (49%), Gaps = 24/266 (9%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-----------EKEETDIMH----LRKLN 60
+ ++ LGSG G VY G RG VA+K+++ E+ D L L+
Sbjct: 826 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKKSCFAGRSSEQERLTKDFWREARILSNLH 885
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPL-YDFLHSGASFTPRQIIRWAKDIAQGMVY 117
H N+V F GV +G + + E+ G L + L S R+ + A D A GM Y
Sbjct: 886 HPNVVAFYGVVPDGPGGTLATVTEYMVNGSLRHVLLRKDRSLDRRKRLIIAMDAAFGMEY 945
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LH + I+H DLK N+LV + KV DFG SR N GT+ WMAPE++
Sbjct: 946 LHLKNIVHFDLKCDNLLVNMRDTQRPICKVGDFGLSRIKRNTLVSGGVRGTLPWMAPELL 1005
Query: 174 RHEP--CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+SFGV +WE+LT E PY + AI+ G+ + T+ P+P C +
Sbjct: 1006 NGSSNRVSEKVDVFSFGVAMWEILTGEEPYANMHCGAIIGGIVSNTLRPPIPERCDPDWR 1065
Query: 232 LLLNQCWDRVPRNRPPFKIILAHLDI 257
L+ +CW P RP F I L +
Sbjct: 1066 KLMEECWSPDPAARPSFTEITNRLRV 1091
>UniRef50_A2E4G1 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 822
Score = 142 bits (344), Expect = 2e-32
Identities = 92/261 (35%), Positives = 129/261 (49%), Gaps = 15/261 (5%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRG--EMVAVKKL---------REKEETDIMHL 56
D + E I +G G G VY G + G E VA+K L R T+I L
Sbjct: 200 DLVIKHEQIQYEKEIGHGYSGRVYEGYIVGRPEKVAIKVLNGSDTNGAMRRSLRTEITTL 259
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGM 115
L+H +I++ G + +C+I+E Q G L DFL + + TP D+A+GM
Sbjct: 260 STLSHPSILKLLGYTLKSP-FCLIIELLQNGSLADFLKNRPNELTPTDKTLITIDVARGM 318
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRH 175
Y+H + +IHRDLKS N+L+ N A++ DFG R D+ GT WMAPEV+
Sbjct: 319 HYIHEKMLIHRDLKSFNILLDSNKRARICDFGFVRV-DSFEPSTGMIGTPQWMAPEVMMC 377
Query: 176 EPC-SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
P +VDV+SFG+VLWE+LT + PY + + + +P P +L L+
Sbjct: 378 SPMYDNKVDVYSFGIVLWEMLTNQPPYAGIPVQRLPTLIVKNEYRPEIPEGTPPALAGLI 437
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
CW P RP F IL L
Sbjct: 438 KDCWSSDPTKRPSFAEILTKL 458
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 142 bits (343), Expect = 2e-32
Identities = 90/255 (35%), Positives = 132/255 (51%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLRGEM-----VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V SG L+ VA+K L+ +++ D + + + +H NI+R
Sbjct: 594 IGAGEFGEVCSGRLKTPAKKEIPVAIKTLKGGYVDRQRKDFLREASIMGQFDHPNIIRLE 653
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV ++ I++E+ + G L FL H G FT Q++ + IA GM YL + +HR
Sbjct: 654 GVVTKSRPVMIVVEYMENGSLDSFLRKHDG-QFTVIQLVGMLRGIASGMKYLSDMGYVHR 712
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTG---TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR D+ A + TG + W APE I S
Sbjct: 713 DLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRKFSSAS 772
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
D WS+G+V+WE+++ E PY + ++ + E LP P CP SL L+ CW +
Sbjct: 773 DAWSYGIVMWEVMSYGERPYWEMSNQDVILSI-EEGYRLPAPMGCPVSLHQLMLHCWQKD 831
Query: 242 PRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 832 RNIRPKFSDIVGFLD 846
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep:
Eph receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 142 bits (343), Expect = 2e-32
Identities = 89/255 (34%), Positives = 133/255 (52%), Gaps = 22/255 (8%)
Query: 23 GSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFRG 69
G G G VY G L+ G+ VA+K L+ EK+ D + + + +H NI+R G
Sbjct: 585 GRGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 644
Query: 70 VCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDL 128
V ++ II EF + G L FL FT Q++ + IA GM YL +HRDL
Sbjct: 645 VVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDL 704
Query: 129 KSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSERV 182
+ N+LV NLV KVSDFG SR ++++ ++T + V W APE I + +
Sbjct: 705 AARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSAS 764
Query: 183 DVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+G+V+WE+++ E PY + ++ + + LP P CP +L L+ CW +
Sbjct: 765 DVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPPMDCPAALHQLMLDCWQKD 823
Query: 242 PRNRPPFKIILAHLD 256
+RP F I+ LD
Sbjct: 824 RNSRPRFAEIVNTLD 838
>UniRef50_Q9SA26 Cluster: F3O9.7 protein; n=3; Arabidopsis
thaliana|Rep: F3O9.7 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 1147
Score = 141 bits (342), Expect = 3e-32
Identities = 92/268 (34%), Positives = 133/268 (49%), Gaps = 24/268 (8%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEET------DIMHLRK 58
+ + ++ LGSG G VY G RG VA+K+++ E+E + L K
Sbjct: 861 DDLEELKELGSGTFGTVYHGKWRGSDVAIKRIKKSCFAGRSSEQERLTGEFWGEAEILSK 920
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFL-HSGASFTPRQIIRWAKDIAQGM 115
L+H N+V F GV +G + + E+ G L L R+ + A D A GM
Sbjct: 921 LHHPNVVAFYGVVKDGPGATLATVTEYMVDGSLRHVLVRKDRHLDRRKRLIIAMDAAFGM 980
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH + I+H DLK N+LV + KV DFG S+ N GT+ WMAPE
Sbjct: 981 EYLHAKNIVHFDLKCDNLLVNLKDPSRPICKVGDFGLSKIKRNTLVSGGVRGTLPWMAPE 1040
Query: 172 VIR--HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ SE+VDV+SFG+VLWE+LT E PY + AI+ G+ T+ +P+ C
Sbjct: 1041 LLNGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPTIPSYCDSD 1100
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLDI 257
++L+ +CW P RP F I L +
Sbjct: 1101 WRILMEECWAPNPTARPSFTEIAGRLRV 1128
>UniRef50_A2ETT9 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 779
Score = 141 bits (342), Expect = 3e-32
Identities = 96/313 (30%), Positives = 161/313 (51%), Gaps = 21/313 (6%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREKE---------ETDIMHLR 57
W V + + ++ +G G VVY G + G VA+KK + K + + L
Sbjct: 193 WIVDYSNFEEIKEIGGGVSSVVYYGRDKRTGNEVAIKKFKFKRLNGPRLQSYQREAAVLA 252
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
NH ++ GV ++ +CIIME+ LY LHS T R I + DIA+GM
Sbjct: 253 NANHPALLHLVGV-TDKIPFCIIMEWMPNHSLYHDLHSYHHLDATGRSITLY--DIARGM 309
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIR- 174
+LHNR+I+HRDLKS NVL+ + ++ DFG SR + + + GT WMAPEV++
Sbjct: 310 QFLHNRQIVHRDLKSLNVLLDKDDRIRICDFGFSRHATDTTFMKHNIGTPHWMAPEVLQT 369
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ + ++DV++F +V WE+ ++PY+ +++++I+ V + +P ++ L+
Sbjct: 370 NGRYTSKIDVYAFAIVAWEIAVGKVPYQGMDSNSIIHQVLNNDLRPQIPEDLNPPMRDLI 429
Query: 235 NQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFS--VTQ-ATWRKEIENEMKEIYTR 291
CW+R P RP F I+ L F+ F V Q + ++++N++K+I +
Sbjct: 430 TMCWERDPDIRPTFDEIVKRLSTGEIVFNGCDVSEFKKYVAQTSNTSEQLKNDVKKILSD 489
Query: 292 -NKEKFEQAQKLQ 303
Q +KLQ
Sbjct: 490 IGNNTANQIRKLQ 502
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 141 bits (342), Expect = 3e-32
Identities = 89/259 (34%), Positives = 132/259 (50%), Gaps = 15/259 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------RKL 59
+ +E+P I + LG G G V+ G R + VAVK LRE + L +K
Sbjct: 275 DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKF 334
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMVY 117
H+ +V VCS+ E I+ E+ G L DFL G +I A +A GM Y
Sbjct: 335 RHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEY 394
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIRH 175
L ++++IHRDL + NVL+ +N VAK+ DFG +R D V W APE I +
Sbjct: 395 LESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIY 454
Query: 176 EPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNS--CPESLKL 232
S + DVWS+G++L EL T ++PY + + ++ + +P P + P+++
Sbjct: 455 GKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENI-ERGFRMPKPTNHYFPDNIYQ 513
Query: 233 LLNQCWDRVPRNRPPFKII 251
LL QCWD VP RP F+ +
Sbjct: 514 LLLQCWDAVPEKRPTFEFL 532
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 141 bits (342), Expect = 3e-32
Identities = 94/278 (33%), Positives = 147/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
+ WEVP E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 986 DKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLN 1045
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--------GASFTP-- 101
+++ N ++VR GV S+G+ +IME G L +L S TP
Sbjct: 1046 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSL 1105
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ K +HRDL + N +V ++ K+ DFG +R+ ++ +
Sbjct: 1106 KKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKG 1165
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ + +L V E
Sbjct: 1166 GKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV-MEG 1224
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1225 GLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSI 1262
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 141 bits (341), Expect = 4e-32
Identities = 97/255 (38%), Positives = 134/255 (52%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+GSG G V G +R G+ VA+K L+ EK++ D + + + +H N++R
Sbjct: 421 IGSGEFGEVCYGRMRLPGKRDIPVALKTLKVGYTEKQKRDFLAEASIMAQFDHPNVIRLE 480
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV + + II E+ + G L FL H G FT Q++ + IA GM YL + IHR
Sbjct: 481 GVVTHSKPVMIITEYMENGSLDSFLRRHDG-QFTIIQLVGLLRGIAAGMTYLSDLGYIHR 539
Query: 127 DLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERV 182
DL + N+LV NLV KVSDFG SR E D ++A + G + W APE I S
Sbjct: 540 DLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSGGKIPIRWTAPEAITFRKFSSSS 599
Query: 183 DVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWS+GVV+WE+ + E PY L ++ V E LP P CP +L L+ CW +
Sbjct: 600 DVWSYGVVMWEVTSYGERPYWNLTNRDVIKSV-EEGYRLPAPMGCPAALHTLMLDCWQKD 658
Query: 242 PRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 659 RNERPRFCQIVTVLD 673
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=8; Clupeocephala|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 714
Score = 141 bits (341), Expect = 4e-32
Identities = 89/260 (34%), Positives = 133/260 (51%), Gaps = 18/260 (6%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR----EKEETDIMH----LRKLNHDNIV 65
E + G ++G R +VAVK LR ++E+ + L + +H N++
Sbjct: 356 EEVIGAAQFGEVSRGRYRPLGRREVLVAVKTLRWGASDREKGMFLSEAGVLGQFDHPNVL 415
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKII 124
+ GV + I+ EF + GPL FL F+ Q++ + I GM YL R +
Sbjct: 416 KLEGVITRTPPERIVTEFMENGPLDSFLRENEGQFSVLQLVGMLRGIGAGMRYLAERNFV 475
Query: 125 HRDLKSPNVLVADNLVAKVSDFGTSREWDN-ESAVMSFTGT------VAWMAPEVIRHEP 177
HRDL + NVLV NLV KVSDFG SR + + ++T + V W APE +H
Sbjct: 476 HRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNIPTYTASLGSKIPVRWTAPEAFQHRK 535
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S DVWSFGV++WE+++ E PY + ++ V + LP P+SCP +L L+ Q
Sbjct: 536 FSSASDVWSFGVLMWEVMSYGERPYWDMSNQEVMKAV-ADQYRLPAPHSCPPALHSLMLQ 594
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW +RP F+ +L+ LD
Sbjct: 595 CWQADRGDRPAFETLLSSLD 614
>UniRef50_Q5K4U1 Cluster: LIN-45 RAF; n=1; Meloidogyne
artiellia|Rep: LIN-45 RAF - Meloidogyne artiellia
(British root-knot nematode)
Length = 880
Score = 141 bits (341), Expect = 4e-32
Identities = 95/275 (34%), Positives = 143/275 (52%), Gaps = 27/275 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLR 57
EDW + E++ +G+G+ G VY + G VAVKKL + ++ LR
Sbjct: 565 EDWAIRNENVILKEKIGNGSFGTVYKADYFGT-VAVKKLNITSPGPELSLAFKNEVTVLR 623
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH---SGASFTPRQIIRWAKDIAQG 114
K H N++ F GV E E I+ ++C LY LH F + I+ K I+QG
Sbjct: 624 KARHGNVLNFLGVIKEPE-LAIVTQWCSGSSLYRHLHVLEPKVDFELQTILDICKQISQG 682
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG------TSREWDNESAVMSFTGTVAWM 168
M YLH+R +IHRDLK+ N+ +++ K+ DFG S N + + TG++ WM
Sbjct: 683 MNYLHSRGVIHRDLKTNNIFLSEGTTVKIGDFGLATVKTRSNALPNGAPNPNPTGSILWM 742
Query: 169 APEVIR---HEPCSERVDVWSFGVVLWELLTQEIPYKTLE-THAILWGVGTETILLPVPN 224
APEVIR P S + DV++FG+ L+ELLT ++PY+ ++ IL+ VG+ + + N
Sbjct: 743 APEVIRMQCENPYSTQSDVYAFGICLYELLTSKLPYEDIKGRDQILFMVGSGLLRPNIKN 802
Query: 225 ---SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P L+ + QC RP F++I A LD
Sbjct: 803 LRSDTPRPLRSVFEQCIRFERSERPEFRMIYAILD 837
>UniRef50_Q54XQ2 Cluster: RGS domain-containing protein; n=2;
Dictyostelium discoideum|Rep: RGS domain-containing
protein - Dictyostelium discoideum AX4
Length = 1125
Score = 141 bits (341), Expect = 4e-32
Identities = 83/259 (32%), Positives = 138/259 (53%), Gaps = 16/259 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLRE-----------KEETDIMHLRK 58
E+ + ++ ++ SG+ G VY+G +G+ VA+K L K E +M + K
Sbjct: 836 EISYSDVSIHKWIASGSSGRVYNGQYKGKDVAIKVLGPEVCVHFDLNEFKREVALMSIFK 895
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVY 117
HDN+ R G + Y + E+C G L+ +L + + Q + +A IA+GM Y
Sbjct: 896 --HDNLARCLGAGQYDDKYFHLTEYCHNGSLFSYLRDQRNNISFGQRLHFALGIARGMRY 953
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
LH+ IIHRDLKS N+L+ L K+ DFGTSR N+ + + GT AWMAPE+
Sbjct: 954 LHSMSIIHRDLKSMNILLTKRLKIKIVDFGTSRV-ANKYNMTTHVGTQAWMAPEIFTSRT 1012
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
+ +VDV+S+ ++L+E+ T++ Y + + + + +P S+ ++ +C
Sbjct: 1013 YTNKVDVYSYAIILFEIFTRKSAYDE-NANINIPNMVMKGERPELPKDMQTSISNIIKKC 1071
Query: 238 WDRVPRNRPPFKIILAHLD 256
W + P NRP F I+A+L+
Sbjct: 1072 WQQKPSNRPSFIKIVAYLE 1090
>UniRef50_A2DQD6 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 979
Score = 141 bits (341), Expect = 4e-32
Identities = 94/277 (33%), Positives = 141/277 (50%), Gaps = 23/277 (8%)
Query: 21 YLGSGAQGVVYSGNLR--GEMVAVKKLREKEET---------DIMHLRKLNHDNIVRFRG 69
+LG+G G V L+ E VAVKK+R + + +I ++KL+H I+ G
Sbjct: 100 HLGAGGFGTVSKATLKRTSEFVAVKKIRYDKLSPKAWQSIWDEITLMKKLHHPCILELVG 159
Query: 70 VCSEGENYCIIMEFCQYGPLYDFLHSGAS-----FTPRQIIRWAKDIAQGMVYLHNRKII 124
E YCII FC L+D LH + P ++ + A IA GM YLH +KI+
Sbjct: 160 AQIH-EPYCIITRFCSGRSLFDRLHRQKTNQLPALQPTELTKIAYQIALGMEYLHAQKIV 218
Query: 125 HRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDV 184
HRDLK+ N+L+ D A ++DFG S +N+ + GT + APE++ H + +VDV
Sbjct: 219 HRDLKTLNILLDDKNNAVIADFGLSGHVENQ--MNESVGTPHYSAPEMLVHTAYTSKVDV 276
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
+S+ +V+WE+LT E+P+ I V T LP+P+S L L+ CW + P
Sbjct: 277 YSYAIVVWEMLTGEVPFNDKVLDKIYEHVVTFGWRLPIPDSASPGLVKLITTCWSKDPTE 336
Query: 245 RPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEI 281
RP F I+ + +F PD + +KEI
Sbjct: 337 RPEFHQIVKQFEDGLIKF----PDSDDLDYTMIKKEI 369
>UniRef50_A0DHI3 Cluster: Chromosome undetermined scaffold_50, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_50, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 1270
Score = 141 bits (341), Expect = 4e-32
Identities = 87/266 (32%), Positives = 140/266 (52%), Gaps = 18/266 (6%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL--REKEET-------DIMHLRK 58
D+ + + + + SG GVVY G + ++VA+K + EK+E +I+ L K
Sbjct: 1002 DFIIQYHELVFYEQIASGGSGVVYRGKYKNQIVAIKDIDINEKDEQKMKEYKREIVTLVK 1061
Query: 59 L-NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI--IRWAKDIAQGM 115
+ +H N+V G+ II EFC G L+D +H Q+ ++ + IA+GM
Sbjct: 1062 VRHHQNLVCLIGITFNQNKLYIITEFCSGGSLFDLIHRNRETNIDQLTKLKLSLFIAEGM 1121
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVA----KVSDFGTSREWDNESAVMS-FTGTVAWMAP 170
Y+H +HRDLKS N+L+ A K++DFG +R ++ M+ GT WMAP
Sbjct: 1122 AYIHKLGFMHRDLKSLNILLDQPFSADSNIKIADFGLARTALEKTEWMTAVVGTFHWMAP 1181
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLP-VPNSCPES 229
EV R E + + DV+S+G+VL+E+ +++IPY + + TE P + C +
Sbjct: 1182 EVFRGEMYTNKADVYSYGIVLYEIFSRQIPYMNIANPMQIMRAVTEQNQRPDLQFECQQE 1241
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+K L+ QCW P RP F+ I+ +L
Sbjct: 1242 MKALMAQCWHPNPDQRPTFEQIINNL 1267
Score = 52.4 bits (120), Expect = 2e-05
Identities = 55/215 (25%), Positives = 99/215 (46%), Gaps = 29/215 (13%)
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ--IIRWAKDIAQGM 115
KL I + +G S +I+E C G L D + + + P + ++ A+DI + +
Sbjct: 65 KLEKSGITQLQGQTSG----ILILENCSKGSLIDLMTTYINRRPPEQLVLMVARDIVKAL 120
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG--TSREW---DNESA-----VMSFTGTV 165
+ +H +HRD+K NVL+ K+ DFG T ++ DN + + T
Sbjct: 121 IQIHQLGYVHRDVKMENVLLNSLGYFKLCDFGSVTKTKYYKIDNTNRDTIKDEIEENTTP 180
Query: 166 AWMAPEVI---RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPV 222
+ APE I + P +E D+++ GV+L+ Q+ P+++ G+ +
Sbjct: 181 FYRAPEYIDFYANYPITESADIFALGVLLFMFCFQKPPFES--------GLAAVNNHYFI 232
Query: 223 PNSCPESLKL--LLNQCWDRVPRNRPPFKIILAHL 255
P+S S KL L+ + P+NRP + +L +
Sbjct: 233 PDSHEYSPKLIQLIQSLFSVNPKNRPTAQELLQRI 267
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 141 bits (341), Expect = 4e-32
Identities = 89/255 (34%), Positives = 131/255 (51%), Gaps = 13/255 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEE--TD----IMHLRK 58
++ WE P LG G G V+ G G + VA+K ++ TD I L+
Sbjct: 220 QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKG 279
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L H+ ++R VCS GE I+ E + G L FL + G + ++ +A +A+GM
Sbjct: 280 LRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMS 339
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL ++++HRDL + NVLV D L KV+DFG +R + D S S V W APE
Sbjct: 340 YLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAAN 399
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S++ DVWSFGV+L E+ T + PY+ + H L + LP P +CP + +L
Sbjct: 400 YRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGYRLPRPAACPAEVYVL 458
Query: 234 LNQCWDRVPRNRPPF 248
+ +CW P RP F
Sbjct: 459 MLECWRSSPEERPSF 473
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 141 bits (341), Expect = 4e-32
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 16/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR--EKEETDIMH----LRKL 59
+ WE+ SI + LGSG G V+ G VAVK L+ + D + ++ L
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL 284
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMVY 117
H +++ VC+ + II E ++G L ++L + G+ Q + A +A GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMS---FTGTVAWMAPEV 172
L +R IHRDL + NVLV ++ + KV+DFG +R + DNE S V W APE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
IR S + DVWSFG++L+E++T ++PY + T A + + + LP P++CP+
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 232 LLLNQCWDRVPRNRPPFKII 251
++ +CW+ P+ RP F+ +
Sbjct: 464 NIMLECWNAEPKERPTFETL 483
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 141 bits (341), Expect = 4e-32
Identities = 87/268 (32%), Positives = 140/268 (52%), Gaps = 22/268 (8%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLR----EKEETDIMH----L 56
E+ + +G+G G V SG+L+ G+ VA+K L+ EK+ D + +
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H N++ GV ++ II EF + G L FL FT Q++ + IA GM
Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMA 169
YL + +HRDL + N+LV NLV KVSDFG SR +++++ ++T + W A
Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE I++ + DVWS+G+V+WE+++ E PY + ++ + + LP P CP
Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPMDCPS 853
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
+L L+ CW + +RP F I+ LD
Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>UniRef50_Q5FBD1 Cluster: Serine/threonine protein kinase ARAF;
n=10; Deuterostomia|Rep: Serine/threonine protein kinase
ARAF - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 608
Score = 140 bits (340), Expect = 5e-32
Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 22/268 (8%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMHLRKL 59
WEV ++ + +G+G+ G V+ G G+ VA+K L+ E T ++ LRK
Sbjct: 305 WEVHPREVSMLKRIGAGSFGTVFKGKWHGD-VAIKILKVTEPTPEQLQAFKNEMQVLRKT 363
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYL 118
H NI+ F G + N+ II ++C+ LY LH + F + I A+ AQGM YL
Sbjct: 364 RHVNILLFMGFMTR-PNFAIITQWCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYL 422
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFG---TSREWDNESAVMSFTGTVAWMAPEVIRH 175
H + IIHRDLKS N+ + + K+ DFG W V +G++ WMAPEVIR
Sbjct: 423 HAKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQPSGSILWMAPEVIRM 482
Query: 176 E---PCSERVDVWSFGVVLWELLTQEIPYKTLETH-AILWGVGTETI---LLPVPNSCPE 228
+ P + + DV+ +GVVL+EL++ +PY + I++ VG + L + ++CP+
Sbjct: 483 QDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLSPDLSKLYSNCPK 542
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
S+K L+ C RP F IL ++
Sbjct: 543 SMKRLIIDCLKFKRDERPLFPQILVSIE 570
>UniRef50_Q9SAJ2 Cluster: T8K14.1 protein; n=3; Arabidopsis
thaliana|Rep: T8K14.1 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 1248
Score = 140 bits (340), Expect = 5e-32
Identities = 92/268 (34%), Positives = 132/268 (49%), Gaps = 24/268 (8%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEET------DIMHLRK 58
E + ++ LGSG G VY G RG VA+K+++ E+E + L K
Sbjct: 962 EDLEELRELGSGTFGTVYHGKWRGSDVAIKRIKKSCFAGRSSEQERLTGEFWGEAEILSK 1021
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFL-HSGASFTPRQIIRWAKDIAQGM 115
L+H N+V F GV +G + + E+ G L L R+ + A D A GM
Sbjct: 1022 LHHPNVVAFYGVVKDGPGGTLATVTEYMVDGSLRHVLVRKDRHLDRRKRLIIAMDAAFGM 1081
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH++ +H DLK N+LV + KV DFG S+ N GT+ WMAPE
Sbjct: 1082 EYLHSKNTVHFDLKCDNLLVNLKDPSRPICKVGDFGLSKIKRNTLVSGGVRGTLPWMAPE 1141
Query: 172 VIR--HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ SE+VDV+SFG+VLWE+LT E PY + AI+ G+ T+ +P C +
Sbjct: 1142 LLNGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPTIPGFCDDE 1201
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHLDI 257
+ L+ +CW P RP F I L +
Sbjct: 1202 WRTLMEECWAPNPMARPSFTEIAGRLRV 1229
>UniRef50_A4SBG1 Cluster: Predicted protein; n=2; Ostreococcus|Rep:
Predicted protein - Ostreococcus lucimarinus CCE9901
Length = 272
Score = 140 bits (340), Expect = 5e-32
Identities = 88/268 (32%), Positives = 137/268 (51%), Gaps = 21/268 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET-----------DIMHLRK 58
E+P + + +G GA G V+ G RG VA+K+L + ++ L +
Sbjct: 3 EIPLDHLEFGRQIGRGAFGEVFRGKYRGTDVAIKRLCVLSDVSDERGLAEFKRELSFLTR 62
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGMVY 117
L H +IV+F G + N CIIM++C G LY +LH+ + + ++++W + A+G+VY
Sbjct: 63 LRHRHIVQFIGASTAPPNLCIIMDYCDKGSLYAYLHNPNKTLSAFKVLKWMSEAAKGLVY 122
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES---AVMSFTGTVAWMAPEVIR 174
LH IIHRD+KS N+ + D K+ DFG S+ S +MS GT +MAPE++
Sbjct: 123 LHASDIIHRDVKSGNLFIDDGGSIKLGDFGLSKFHTGASTSGGMMSLVGTYQFMAPELLE 182
Query: 175 HEP-CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGV--GTETILLPVPN---SCPE 228
+P + VDV+SF VV+WE LT+E P+ L I+ + G L PE
Sbjct: 183 GQPRYTTAVDVYSFAVVMWECLTREDPFSGLSPMQIVAALLRGERPSLDDASKFAVRLPE 242
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW RP + I L+
Sbjct: 243 EYIAVIARCWRADALERPTMEDIAPELE 270
>UniRef50_Q54TH6 Cluster: LISK family protein kinase; n=1;
Dictyostelium discoideum AX4|Rep: LISK family protein
kinase - Dictyostelium discoideum AX4
Length = 597
Score = 140 bits (340), Expect = 5e-32
Identities = 93/259 (35%), Positives = 138/259 (53%), Gaps = 13/259 (5%)
Query: 5 SEEDWEVPFESITDM-MYLGSGAQGVVYSGNLRGEMVAVKKLREK-EETDIMH------L 56
+++ W + ++ + + +GSG G V G G VA+KKL E EET+I+ L
Sbjct: 322 TKDMWNIDYKELKFVGNEIGSGKYGSVSLGYWLGTPVAIKKLHENNEETEILVQRELQIL 381
Query: 57 RKLNHDNIVRFRGVC-SEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQG 114
+++ H IV+F GV +E + II EF G L+D L G T ++ +R + DIAQ
Sbjct: 382 KEIRHPQIVQFLGVSRNEKDEIHIITEFMDGGDLFDALIFGDIPLTWKEKLRISLDIAQS 441
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVI 173
+LH R I+HRDLKS N+L++ N AK+ D G +R ++ + + GT WMAPEV
Sbjct: 442 CRFLHARGILHRDLKSQNILLSTNRRAKLCDLGLARMFEERINKRYTCVGTEIWMAPEVC 501
Query: 174 RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S VDV+SFG+VL E++T++IP + H + L VP CP L
Sbjct: 502 LDQSYSTAVDVFSFGIVLVEIITEKIPDERFPQHRFQF--DAPAFLKKVPKECPPDFSKL 559
Query: 234 LNQCWDRVPRNRPPFKIIL 252
C P+ RP F +L
Sbjct: 560 CVDCTKYNPKERPSFIKVL 578
>UniRef50_Q019B0 Cluster: Tyrosine kinase specific for activated
(GTP-bound) p21cdc42Hs; n=2; Ostreococcus|Rep: Tyrosine
kinase specific for activated (GTP-bound) p21cdc42Hs -
Ostreococcus tauri
Length = 388
Score = 140 bits (339), Expect = 7e-32
Identities = 95/253 (37%), Positives = 132/253 (52%), Gaps = 21/253 (8%)
Query: 25 GAQGVVYSGNLRGEMVAVKKL-------REKEETDIMHLRKLNHDNIVRFRGVCSEGENY 77
G V+ G +G +VAVK+L +EK E ++ L KL H N++ F G C +
Sbjct: 84 GGFAEVFRGTWQGTVVAVKQLLERTSEVKEKLEQEVQVLAKLRHPNLLLFMGYCVDPPLI 143
Query: 78 CIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRK--IIHRDLKSPNVLV 135
C EF + G L+ L +G P + A +A+GM YLH+R I+H DLKSPN+LV
Sbjct: 144 CT--EFMRRGSLHTILKAGKPLEPARNHAIALAVARGMSYLHSRSPPILHLDLKSPNILV 201
Query: 136 ADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWE 193
+ K++DFG +R + SA F GT WMAPE++R E E D +S+GVVLWE
Sbjct: 202 DEKWRVKIADFGLARMRQTTQMSAKSQFHGTPEWMAPEMLRAEDYDEHADSYSYGVVLWE 261
Query: 194 LLTQEIPYKTLETHAILWGVGTETILLPVPN-SCPES-------LKLLLNQCWDRVPRNR 245
L+T P++ L I+ VG L +P+ PES L + +C R P R
Sbjct: 262 LITAHKPWEDLHPMQIVAVVGYSGRSLELPSEGFPESSHPLTALLADIFTRCARRDPSAR 321
Query: 246 PPFKIILAHLDIA 258
P F IL L+ A
Sbjct: 322 PLFPAILTDLERA 334
>UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Ciona
intestinalis|Rep: Ephrin receptor like protein - Ciona
intestinalis (Transparent sea squirt)
Length = 1085
Score = 140 bits (339), Expect = 7e-32
Identities = 89/260 (34%), Positives = 131/260 (50%), Gaps = 26/260 (10%)
Query: 22 LGSGAQGVVYSGNLR-----GEM----VAVKKLREK----EETDIMH----LRKLNHDNI 64
+G G G VY G+L G+ VA+K+L + E+ D +H L + H NI
Sbjct: 722 IGCGEFGEVYQGSLTLTDTGGKRKVIDVAIKQLHAQCQPNEQIDFLHEAKALERFQHPNI 781
Query: 65 VRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGAS--FTPRQIIRWAKDIAQGMVYLHN 120
V+ V + I+ E G L FL H GA F P ++R +A+GM YL
Sbjct: 782 VKLEAVVMASRPFMIVTELMVNGCLGKFLRHHRGAKRYFKPTVLVRMLHGVAKGMAYLSK 841
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAWMAPEVIRHEP 177
+HRDL + NVL+ + LV KV+DFG R + + ++ G ++ W APE + ++
Sbjct: 842 MCYVHRDLAARNVLINNELVCKVADFGLIRHIGEKKSTVNTKGGKISLRWTAPEAVAYQA 901
Query: 178 CSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S+ DVWSFGV WE++T E PY +L +L + + LP P CP L L+ +
Sbjct: 902 YSQASDVWSFGVFAWEVITYGEKPYWSLTNQQVLQAI-NDGYRLPAPEDCPSVLHQLMLE 960
Query: 237 CWDRVPRNRPPFKIILAHLD 256
CW R RP F+ ++ LD
Sbjct: 961 CWHRDKNTRPTFEQVVTRLD 980
>UniRef50_A2E0X6 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1103
Score = 140 bits (339), Expect = 7e-32
Identities = 97/315 (30%), Positives = 159/315 (50%), Gaps = 16/315 (5%)
Query: 22 LGSGAQGVVYSGNLR--GEMVAVKKL------REKEETDIMHLR---KLNHDNIVRFRGV 70
+G GA VY G + G VA+KKL +E+ ET + +R LNH I F GV
Sbjct: 216 IGQGAFSTVYHGFQKSTGHPVAMKKLNSGILTKEQFETYLREIRILTSLNHFAITPFVGV 275
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKIIHRDLK 129
+ E Y II + + L+ LH+ + +P ++ A IA G+ YLH+ KI+HRD+K
Sbjct: 276 TPK-EPYYIITQLMRGDCLFYRLHAQRNPLSPTKLTIIALGIAYGLAYLHSEKIMHRDIK 334
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
S N+L+ ++ + DFG +R D + GT WMAPE+ + S +VD++S+G+
Sbjct: 335 SLNILLDNDDYPHICDFGCARFMDGRRYSIK-VGTTQWMAPEMYEIDCYSFKVDIYSYGI 393
Query: 190 VLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFK 249
+LWE+LT +IP+ L+ IL V P+P+SCP L L+ CWD P RP
Sbjct: 394 LLWEMLTGQIPFANLKDVDILPMV-INGERPPIPSSCPSGLAKLIKSCWDVDPNKRPSSA 452
Query: 250 IILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVRREE 309
I+ + F D+ + + ++ E ++ N A ++ + + +
Sbjct: 453 QIVQVFERGEVFFQDADMDKVEIYRKSFAMSAETQINNFDVNNVNSMHLADIIEMIIKGD 512
Query: 310 LRLARDTRLIYEQQL 324
++ +++ + Y QL
Sbjct: 513 MQ-SKNKAIGYLAQL 526
>UniRef50_UPI00006CE4F4 Cluster: Protein kinase domain containing
protein; n=1; Tetrahymena thermophila SB210|Rep: Protein
kinase domain containing protein - Tetrahymena
thermophila SB210
Length = 1011
Score = 140 bits (338), Expect = 1e-31
Identities = 79/230 (34%), Positives = 129/230 (56%), Gaps = 12/230 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-----EKEETDIMH----L 56
+ + E+ F + + G G++Y R +VAVKK + +++ + ++ +
Sbjct: 755 QSNLEIKFSDLEIQNKITEGGYGIIYKAKWREIVVAVKKFKIDYNNQQQIVEFVNECNAM 814
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGM 115
L H NIV F G C+E N+ I+ME+CQ G L+ L + T + A DIA+G+
Sbjct: 815 EALRHPNIVLFLGACTEIPNFSIVMEYCQRGSLWSLLQNQSVPLTWEDRRKIALDIAKGV 874
Query: 116 VYLHNRK--IIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
+LH+ K IIHRDLKS NVLV DN K++DFG +R ++ + + GT WMAPEVI
Sbjct: 875 FFLHSSKPPIIHRDLKSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNKIGTYQWMAPEVI 934
Query: 174 RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVP 223
+ +E+ DV+S+ ++LWE+ ++E PY+ ++ + V E + +P
Sbjct: 935 KAFYYTEKADVFSYSIILWEIASREPPYRGIKGDVVAEKVMCENLRPIIP 984
>UniRef50_UPI00004986C0 Cluster: protein kinase; n=1; Entamoeba
histolytica HM-1:IMSS|Rep: protein kinase - Entamoeba
histolytica HM-1:IMSS
Length = 686
Score = 140 bits (338), Expect = 1e-31
Identities = 85/247 (34%), Positives = 128/247 (51%), Gaps = 12/247 (4%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKE---------ETDIMHLRKLNHDNIVRFRGVCS 72
+GSG+ G VYS RG+ +AVK + K ++ ++KL H +++F G +
Sbjct: 416 MGSGSYGDVYSALWRGQEIAVKLIPTKNMLQDSVLQFTKEVQLMKKLRHPCVLQFFGSGT 475
Query: 73 EGENYCIIMEFCQYGPLYDFL-HSGASFTPRQIIRWAKDIAQGMVYLHNRK--IIHRDLK 129
+ I ME + G + L + + +R KD A GM YLH+ IIH DLK
Sbjct: 476 DANFILIAMELMRRGSAHTLLMNKSLPINWERRLRMLKDAASGMFYLHSLTPPIIHLDLK 535
Query: 130 SPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
S N+LV DN KVSDFG S S GT+AW APE+++ +P S + DV+S+ +
Sbjct: 536 SHNLLVDDNWKVKVSDFGLSMTSIEGLHSNSVCGTLAWTAPEMLKGKPVSTKADVYSYAI 595
Query: 190 VLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFK 249
V+WE L + PY + ++ VG I +P + + L+ +CW+ P +RP F
Sbjct: 596 VMWEFLARADPYPDIPRFHLIEKVGEIGIRPDIPQNNHIAYCELMQRCWETRPEDRPDFS 655
Query: 250 IILAHLD 256
IL +LD
Sbjct: 656 EILVYLD 662
>UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1006
Score = 140 bits (338), Expect = 1e-31
Identities = 100/276 (36%), Positives = 139/276 (50%), Gaps = 31/276 (11%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGE-----MVAVKKLR----EKEETDIMH----L 56
E+ SI +G G G V SG LR + VA+K L+ +K+ D + +
Sbjct: 655 EIDVSSIHIERVIGMGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRDFLSEASIM 714
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQG 114
+ +H NI+R GV + + II E+ + G L FL H G FT Q++ + IA G
Sbjct: 715 GQFDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAFLRKHDG-QFTVIQLVGMLRGIASG 773
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESA--VMSFTGT------ 164
M YL + +HRDL + N+LV NLV KVSDFG SR E D E+A TGT
Sbjct: 774 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRENTGTYLSPGG 833
Query: 165 ---VAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILL 220
+ W APE I + + DVWS+G+V+WE+++ E PY + ++ + E L
Sbjct: 834 KIPIRWTAPEAIAYRKFTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAI-EEGYRL 892
Query: 221 PVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P P CP L L+ CW+R RP F IL LD
Sbjct: 893 PAPMDCPLVLHQLMLDCWERERAERPTFSQILNMLD 928
>UniRef50_A7QS17 Cluster: Chromosome undetermined scaffold_155, whole
genome shotgun sequence; n=1; Vitis vinifera|Rep:
Chromosome undetermined scaffold_155, whole genome
shotgun sequence - Vitis vinifera (Grape)
Length = 1272
Score = 140 bits (338), Expect = 1e-31
Identities = 91/264 (34%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK--------EE-------TDIMHLRKLN 60
+ ++ LGSG G VY G RG VA+K++ ++ +E + + L L+
Sbjct: 989 LEELRELGSGTFGTVYHGKWRGTDVAIKRINDRCFAGKPSEQERMRDDFWNEAIKLADLH 1048
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
H N+V F GV +G + + E+ G L + L + R+ + A D+A GM Y
Sbjct: 1049 HPNVVAFYGVVLDGPGGSVATVTEYMVNGSLRNSLQKNEKNLDKRKRLLIAMDVAFGMEY 1108
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LH + I+H DLKS N+LV + KV D G S+ GT+ WMAPE++
Sbjct: 1109 LHGKNIVHFDLKSDNLLVNLRDPHRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELL 1168
Query: 174 RHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+SFG+V+WELLT E PY L AI+ G+ + T+ VP C +
Sbjct: 1169 NGSSSLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVSNTLRPSVPEFCDPEWR 1228
Query: 232 LLLNQCWDRVPRNRPPFKIILAHL 255
L+ +CW P RP F I L
Sbjct: 1229 ALMERCWSSEPSERPSFTEIANQL 1252
>UniRef50_A5AQH5 Cluster: Putative uncharacterized protein; n=1; Vitis
vinifera|Rep: Putative uncharacterized protein - Vitis
vinifera (Grape)
Length = 1401
Score = 140 bits (338), Expect = 1e-31
Identities = 91/264 (34%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 16 ITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREK--------EE-------TDIMHLRKLN 60
+ ++ LGSG G VY G RG VA+K++ ++ +E + + L L+
Sbjct: 1118 LEELRELGSGTFGTVYHGKWRGTDVAIKRINDRCFAGKPSEQERMRDDFWNEAIKLADLH 1177
Query: 61 HDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
H N+V F GV +G + + E+ G L + L + R+ + A D+A GM Y
Sbjct: 1178 HPNVVAFYGVVLDGPGGSVATVTEYMVNGSLRNSLQKNEKNLDKRKRLLIAMDVAFGMEY 1237
Query: 118 LHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVI 173
LH + I+H DLKS N+LV + KV D G S+ GT+ WMAPE++
Sbjct: 1238 LHGKNIVHFDLKSDNLLVNLRDPHRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELL 1297
Query: 174 RHEPC--SERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
SE+VDV+SFG+V+WELLT E PY L AI+ G+ + T+ VP C +
Sbjct: 1298 NGSSSLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVSNTLRPSVPEFCDPEWR 1357
Query: 232 LLLNQCWDRVPRNRPPFKIILAHL 255
L+ +CW P RP F I L
Sbjct: 1358 ALMERCWSSEPSERPSFTEIANQL 1381
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 140 bits (338), Expect = 1e-31
Identities = 93/264 (35%), Positives = 131/264 (49%), Gaps = 13/264 (4%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMH----L 56
L +E WE+ S++ LGSG G V SG +G++ VA+K +RE E D + +
Sbjct: 421 LFDEAWEIDKVSLSLGKELGSGQFGRVVSGKWKGKIDVAIKMMREGAMNEDDFIEEAKVM 480
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ--IIRWAKDIAQG 114
++ H+N+V+ GVC++ I+ E G L FL + I+ A I
Sbjct: 481 KQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKTEIILDMATQICSA 540
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTG-TVAWMAPEV 172
M YL IHRDL + N LV + V KV+DFG +R D+E T + W APEV
Sbjct: 541 MKYLEESGFIHRDLAARNCLVGERNVVKVADFGLARFVVDDEYTASEGTKFPIKWAAPEV 600
Query: 173 IRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLK 231
I H S + DVWSFG++LWEL T + PY T +L V L P CP +
Sbjct: 601 ITHAKFSSKSDVWSFGILLWELWTGGKTPYPTFTNSQVLDEV-LMGYRLDRPKQCPPEVY 659
Query: 232 LLLNQCWDRVPRNRPPFKIILAHL 255
L+ +CW +RP FK + + L
Sbjct: 660 ALMGKCWLTNSDDRPQFKTLSSSL 683
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 140 bits (338), Expect = 1e-31
Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 31/332 (9%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR----GEM---VAVKKLRE----KEETDIMH 55
++WEV E IT + LG G+ G+VY GN R GE VAVK + E +E + ++
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ ++VR GV S+G+ ++ME +G L +L S A P
Sbjct: 1074 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1133
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
+++I+ A +IA GM YL+ +K +HRDL + N +VA + K+ DFG +R+ ++ +
Sbjct: 1134 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1193
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WMAPE ++ + D+WSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1194 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1252
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRVLPDRFSVTQAT 276
L P++CPE + L+ CW P+ RP F +I+ D F V +A
Sbjct: 1253 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAP 1312
Query: 277 WRKEIENEMKEIYTRNKEKFEQAQKLQSVRRE 308
+E+E E +++ ++ Q+ ++ R+
Sbjct: 1313 ESEELEMEFEDMENVPLDRSSHCQREEAGGRD 1344
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 140 bits (338), Expect = 1e-31
Identities = 94/278 (33%), Positives = 146/278 (52%), Gaps = 30/278 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-------VAVKKLRE----KEETDIMH 55
++WEV E IT LG G+ G+VY G +G + VA+K + E +E + ++
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS-------GASFTP--- 101
+++ N ++VR GV S+G+ +IME G L +L S P
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++I+ A +IA GM YL+ K +HRDL + N +VA++ K+ DFG +R+ ++ +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ T E PY+ L +L V E
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEG 1228
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
LL P++CP+ L L+ CW P+ RP F I++ +
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep:
Ephrin receptor - Mus musculus (Mouse)
Length = 819
Score = 139 bits (337), Expect = 1e-31
Identities = 93/266 (34%), Positives = 138/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 485 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 544
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + IA GM
Sbjct: 545 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGM 604
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDFG SR E D E+A + G + W APE
Sbjct: 605 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 664
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 665 AIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 723
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 724 YQLMLDCWQKDRNSRPKFDEIVNMLD 749
>UniRef50_Q9STU7 Cluster: Putative uncharacterized protein
T22A6.310; n=1; Arabidopsis thaliana|Rep: Putative
uncharacterized protein T22A6.310 - Arabidopsis thaliana
(Mouse-ear cress)
Length = 963
Score = 139 bits (337), Expect = 1e-31
Identities = 96/273 (35%), Positives = 135/273 (49%), Gaps = 28/273 (10%)
Query: 8 DW-EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK--------------KLREKEETD 52
DW EV + + +G+G+ G V+ G VAVK LRE +
Sbjct: 660 DWLEVSWNELHIKERVGAGSFGTVHRAEWHGSDVAVKILSIQDFHDDQFREFLREVCKQA 719
Query: 53 IMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH---SGASFTPRQIIRWAK 109
+ ++++ H N+V F G +E II E+ G L+ +H SG R+ +R A
Sbjct: 720 VAIMKRVRHPNVVLFMGAVTERPRLSIITEYLPRGSLFRLIHRPASGELLDQRRRLRMAL 779
Query: 110 DI-------AQGMVYLH--NRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVM 159
D+ A+G+ YLH N ++H DLKSPN+LV N KV DFG SR N
Sbjct: 780 DVVCAIPHYAKGLNYLHCLNPPVVHWDLKSPNLLVDKNWTVKVCDFGLSRFKANTFIPSK 839
Query: 160 SFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETIL 219
S GT WMAPE +R EP +E+ DV+SFGVVLWEL+T + P+ L ++ V +
Sbjct: 840 SVAGTPEWMAPEFLRGEPTNEKSDVYSFGVVLWELITLQQPWNGLSPAQVVGAVAFQNRR 899
Query: 220 LPVPNSCPESLKLLLNQCWDRVPRNRPPFKIIL 252
L +P + L L+ CW P RP F I+
Sbjct: 900 LIIPPNTSPVLVSLMEACWADEPSQRPAFGSIV 932
>UniRef50_Q23927 Cluster: Protein tyrosine kinase; n=3; Dictyostelium
discoideum|Rep: Protein tyrosine kinase - Dictyostelium
discoideum (Slime mold)
Length = 1338
Score = 139 bits (337), Expect = 1e-31
Identities = 83/265 (31%), Positives = 138/265 (52%), Gaps = 11/265 (4%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-------EKEETDIMHLRKLNHD 62
E+ F+ + + +G+G+ V G G VA+K L+ EK ++ L K +H
Sbjct: 1051 EIKFDEVAIVERVGAGSFANVSLGIWNGYKVAIKILKNESISNDEKFIKEVSSLIKSHHP 1110
Query: 63 NIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNR 121
N+V F G + CI E+ Q G LYD LH P + + D++ GM +LH+
Sbjct: 1111 NVVTFMGARIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPLMMYKMIHDLSLGMEHLHSI 1168
Query: 122 KIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSER 181
+++HRDL S N+L+ + K++DFG + ++ + T W +PE+ + +E+
Sbjct: 1169 QMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGITNP-RWRSPELTKGLVYNEK 1227
Query: 182 VDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
VDV+SFG+V++E+ T +IP++ L+ A E +P CP SL+ L+ +CW
Sbjct: 1228 VDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASD 1287
Query: 242 PRNRPPFKIILAHLDIAGAEFSRVL 266
P RP F IL L+ ++F + L
Sbjct: 1288 PSQRPSFTEILTELETMKSKFIKQL 1312
Score = 93.5 bits (222), Expect = 1e-17
Identities = 74/258 (28%), Positives = 119/258 (46%), Gaps = 19/258 (7%)
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVY 117
+ H N+ G C + I F L+D +H G I+ +KDIA M
Sbjct: 814 IQHKNLGLLVGWCGDS---IIFESFKGMNSLHDLIHRDGLKIDMALFIKISKDIASVMGL 870
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
LH++ + H +L S ++ + + KVS F D + + +MAPE+ R E
Sbjct: 871 LHSKDVAHGNLTSRSIYLDRFQIVKVS-FPKLNATDLNNPAIE----PRYMAPEMTRMEE 925
Query: 178 --CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
S +DV+++ VLWE LT +P++ ++ V E + +P SCP ++ L+N
Sbjct: 926 DQISCSIDVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTSCPLFIRKLIN 985
Query: 236 QCWDRVPRNRPPFKIILAHLDIAGAE--FSR-----VLPDRFSVTQATWRKEIENEMKEI 288
+CW +P +RP F IL D G + FS L + V + +KE NE+ E
Sbjct: 986 RCWAPLPSDRPTFNDILKLFDHLGGKLFFSSPGILWSLNNDQEVERELQKKERFNEITEF 1045
Query: 289 YTRNKE-KFEQAQKLQSV 305
KE KF++ ++ V
Sbjct: 1046 LRGKKEIKFDEVAIVERV 1063
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 139 bits (337), Expect = 1e-31
Identities = 88/263 (33%), Positives = 133/263 (50%), Gaps = 12/263 (4%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE--ETDIMH----LR 57
S E WE+ +T M LGSG GVV G R + VA+K +RE E D + +
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQII-RWAKDIAQGMV 116
KL H +V+ GVC++ + I+ EF + G L +FL R ++ +D+ +GM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIR 174
YL IHRDL + N LV++ V KVSDFG +R D ++ V W PEV
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ S + DVWSFGV++WE+ T+ +P++ + ++ V T L P + +
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEV 597
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ +L +D
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTID 620
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 139 bits (337), Expect = 1e-31
Identities = 89/263 (33%), Positives = 140/263 (53%), Gaps = 14/263 (5%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNL-RGEMVAVKKLR------EKEETDIMHLRK 58
++ WE+P ES+ LG+G G V+ + VAVK ++ E + ++
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L HD +V+ V ++ Y II EF G L DFL S G+ ++I ++ IA+GM
Sbjct: 312 LQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNE-SAVMSFTGTVAWMAPEVIR 174
++ R IHRDL++ N+LV+ +LV K++DFG +R DNE +A + W APE I
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWSFG++L E++T IPY + ++ + +P P +CPE L +
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNI 489
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CW P RP F+ I + LD
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLD 512
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 139 bits (337), Expect = 1e-31
Identities = 92/260 (35%), Positives = 130/260 (50%), Gaps = 18/260 (6%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLREK--------EETDIMHL 56
++WE+ I LG G G VY + G VAVK L+E EE IM
Sbjct: 362 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIM-- 419
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI--IRWAKDIAQG 114
+++ H N+V+ GVC+ + II EF +G L DFL S T + + A IA G
Sbjct: 420 KEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASG 479
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEV 172
M YL +R IHRDL + N LV DN + KV+DFG +R D +A + W APE
Sbjct: 480 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEG 539
Query: 173 IRHEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLK 231
+ + S + DVW+FGV+LWE+ T + PY ++ + + + + P CP +
Sbjct: 540 LAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKL-DKGYRMERPPGCPPEVY 598
Query: 232 LLLNQCWDRVPRNRPPFKII 251
L+ QCW +RP FK I
Sbjct: 599 DLMRQCWQWDATDRPTFKSI 618
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 139 bits (336), Expect = 2e-31
Identities = 94/275 (34%), Positives = 146/275 (53%), Gaps = 30/275 (10%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGN----LRGE---MVAVKKLRE----KEETDIMH 55
++WEVP + I + LG G+ G+VY G ++GE VAVK + E +E + ++
Sbjct: 1003 DEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLN 1062
Query: 56 ----LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS---GASFTP------- 101
++ N ++VR GV S+G+ +IME +G L +L S A P
Sbjct: 1063 EASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTL 1122
Query: 102 RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMS 160
++II+ A +I+ GM YL+ +K +HRDL + N +VAD+ K+ DFG +R+ ++ +
Sbjct: 1123 KEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYETDYYRKG 1182
Query: 161 FTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTET 217
G V WM+PE ++ + DVWSFGVVLWE+ + E PY+ L +L V +
Sbjct: 1183 GKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDG 1241
Query: 218 ILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIIL 252
L P +CP L L+ CW P+ RP F I+
Sbjct: 1242 GSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEII 1276
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 139 bits (336), Expect = 2e-31
Identities = 87/266 (32%), Positives = 137/266 (51%), Gaps = 16/266 (6%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMH----L 56
LS + WE+ + M LGSG GVV G RG + AVK ++E E D + +
Sbjct: 514 LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVM 573
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASF-TPRQIIRWAKDIAQ 113
KL H N+V+ GVCS+ I+ E+ ++G L ++L H ++ +++
Sbjct: 574 TKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSK 633
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAP 170
GM YL IHRDL + N LV V KV+DFG +R + + S GT + W P
Sbjct: 634 GMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR-YVLDDQYTSSGGTKFPIKWAPP 692
Query: 171 EVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
EV+ + S + DVW++GV++WE+ T ++PY L+ ++ V I+L P SC +
Sbjct: 693 EVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV-QRGIILEKPKSCAKE 751
Query: 230 LKLLLNQCWDRVPRNRPPFKIILAHL 255
+ ++ CW P RP F++++ L
Sbjct: 752 IYDVMKLCWSHGPEERPAFRVLMDQL 777
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 138 bits (335), Expect = 2e-31
Identities = 90/256 (35%), Positives = 133/256 (51%), Gaps = 22/256 (8%)
Query: 22 LGSGAQGVVYSGNL----RGEMV-AVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G V G L R EMV A+K L+ E++ D + + + +H N++R
Sbjct: 642 IGAGEFGEVCRGRLKQAGRREMVVAIKTLKAGYTERQRRDFLAEASIMGQFDHPNVIRLE 701
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
GV + II EF + G L FL + FT Q++ + +A GM YL + +HRD
Sbjct: 702 GVLTRSCPVLIITEFMENGALDSFLRLNDGRFTMTQLVGMLRGVAAGMKYLSDMNYVHRD 761
Query: 128 LKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT------VAWMAPEVIRHEPCSER 181
L + N+LV NLV KVSDFG SR D+ SA ++T + + W APE I +
Sbjct: 762 LAARNILVNSNLVCKVSDFGLSRFLDDTSADPTYTSSLGGKIPIRWTAPEAIAFRKFTTA 821
Query: 182 VDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDR 240
DVWS+G+V+WE+++ E PY + ++ V + LP P CP L L+ +CW +
Sbjct: 822 SDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAV-EQDYRLPPPMDCPMVLHQLMLECWMK 880
Query: 241 VPRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 881 ERNLRPKFSRIVGTLD 896
>UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 712
Score = 138 bits (335), Expect = 2e-31
Identities = 91/255 (35%), Positives = 132/255 (51%), Gaps = 22/255 (8%)
Query: 22 LGSGAQGVVYSGNLR-----GEMVAVKKLR----EKEETDIMH----LRKLNHDNIVRFR 68
+G+G G VY G L+ VA+K L+ EK+ D + + + H NI+R
Sbjct: 358 IGAGEFGEVYRGILKVPGRKESAVAIKTLKPGYTEKQRQDFLSEASIMGQFAHQNIIRLE 417
Query: 69 GVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
GV ++ ++ II E+ + G L +L H G FT Q++ + IA GM YL + +HR
Sbjct: 418 GVVTKFKHAMIITEYMENGALDRYLRDHDG-EFTSFQLVGMLRGIAAGMKYLSDMSYVHR 476
Query: 127 DLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPEVIRHEPCSERV 182
DL + N+LV + L KVSDFG SR E D E + G + W APE I + +
Sbjct: 477 DLAARNILVNNTLECKVSDFGLSRVLEDDPEGTYTTSGGKIPIRWTAPEAIAYRKFASAS 536
Query: 183 DVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRV 241
DVWSFG+V+WE++ E PY + H ++ + E LP P CP ++ L+ QCW
Sbjct: 537 DVWSFGIVMWEVMAFGERPYWDMSNHEVMKAI-NEAFRLPAPMDCPSAVYQLMLQCWLHD 595
Query: 242 PRNRPPFKIILAHLD 256
RP F I+ LD
Sbjct: 596 RAKRPRFGDIVNLLD 610
>UniRef50_A2FIB7 Cluster: CAMK family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: CAMK family protein kinase
- Trichomonas vaginalis G3
Length = 1065
Score = 138 bits (335), Expect = 2e-31
Identities = 87/256 (33%), Positives = 126/256 (49%), Gaps = 16/256 (6%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKEET---------DIMHLRKL 59
+P + + +G G G VY E++AVK+LR + ++ + +
Sbjct: 212 IPIDDLQIENQIGVGGFGKVYRAIRISTSEILAVKELRSDRISTNSWSSLYAEVETMASV 271
Query: 60 NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA----SFTPRQIIRWAKDIAQGM 115
+H N++ G E Y II FC L+D LH + T ++ A +AQGM
Sbjct: 272 HHKNVLELVGA-HINEPYRIITRFCPGRSLFDRLHRSTHEYKTLTGTELTIIAHQVAQGM 330
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRH 175
YLH I+HRDLK+ N+L+ + A V+DFG S + GT + APEV+ H
Sbjct: 331 CYLHKLGIVHRDLKTLNILLYQDNTACVADFGLSGMVKENQELYGGVGTPHYTAPEVLMH 390
Query: 176 EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLN 235
VD +S+GVVLWE+LT+++PY + AI V T L +P PE LK L+
Sbjct: 391 MKYGPNVDTYSYGVVLWEMLTKKLPYGDMNHMAIYEHVVTRGWRLTIPQDTPEPLKKLIQ 450
Query: 236 QCWDRVPRNRPPFKII 251
+CW R P RP F I
Sbjct: 451 RCWSRDPNERPDFNEI 466
>UniRef50_A2FDP2 Cluster: TKL family protein kinase; n=3;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 801
Score = 138 bits (335), Expect = 2e-31
Identities = 85/247 (34%), Positives = 134/247 (54%), Gaps = 20/247 (8%)
Query: 22 LGSGAQGVVYSGNLRG--EMVAVKKLREKE---------ETDIMHLRKLNHDNIVRFRGV 70
+G G V+S + +M AVKKL+ ++ ++ L K H ++ F G
Sbjct: 31 IGKGGFSEVFSASYTPTKQMCAVKKLKFRDLSGKNFEALSRELQILSKNAHPYLLGFVGF 90
Query: 71 CSEGENYCIIMEFCQYGPLYDFL-----HSGASFTPRQIIRWAKDIAQGMVYLHNRKIIH 125
S + I+ E+ G L+D L H + T + +I A IA GM LH +I+H
Sbjct: 91 -SIDRPFIIVTEYLPNGSLFDALRWKDNHKPLTGTQKTLI--AMCIASGMAKLHKNRIMH 147
Query: 126 RDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMS-FTGTVAWMAPEVIRHEPCSERVDV 184
RDLKS N+L+ ++L+ +V DFG S+ +D + ++ GT WMAPE+ ++ + ++DV
Sbjct: 148 RDLKSLNILLDEDLLPRVIDFGLSKFYDEKDETLTEVLGTTHWMAPELFENKGYTNKIDV 207
Query: 185 WSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
+++GV+LWE+LT IPY I++ V + P+P P LK L+N CWD+ P +
Sbjct: 208 YAYGVLLWEMLTNSIPYAGKSNTQIIYDVVKKGKRPPIPIRTPSGLKNLINACWDQNPNS 267
Query: 245 RPPFKII 251
RP FK I
Sbjct: 268 RPTFKEI 274
>UniRef50_A2EJW7 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 963
Score = 138 bits (335), Expect = 2e-31
Identities = 92/265 (34%), Positives = 147/265 (55%), Gaps = 28/265 (10%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLR--GEMVAVKKLR--EKEETDIMHLRK- 58
L +DW++ E+I G G V+ +R GEMVAVK+L+ + +T +++L++
Sbjct: 190 LKHQDWQIIKENI------GLGGYATVHLAKMRSTGEMVAVKELKAVQLNQTRVIYLKRE 243
Query: 59 ------LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI----IRWA 108
L+H N+++ GV + +CI+ + G L D ++ G S PR +R A
Sbjct: 244 IDALMRLSHPNVIKLIGV-TVTPPFCIVTTYVPNGCLIDLIN-GKSINPRCTPIFRMRIA 301
Query: 109 KDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSF-TGTVAW 167
D A+ + Y+H+ +IHRDLK PN+L+ +N A V DFG +R S++MS GT W
Sbjct: 302 LDTARALEYIHSIGLIHRDLKPPNILLDNNDRAIVCDFGLAR---IVSSMMSCEIGTTQW 358
Query: 168 MAPEVIRH-EPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSC 226
APE++ ++ VDV+++G++LWELLTQ+IP+K L+ I V +P C
Sbjct: 359 CAPELLTSGNDYNQSVDVYAYGIMLWELLTQKIPFKGLKCIQICECVLKYAERPEIPEDC 418
Query: 227 PESLKLLLNQCWDRVPRNRPPFKII 251
PE ++ +CW + P RP F+ I
Sbjct: 419 PEMFATVIKRCWAQHPEERPTFQQI 443
>UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=103;
Euteleostomi|Rep: Ephrin type-A receptor 5 precursor -
Homo sapiens (Human)
Length = 1037
Score = 138 bits (335), Expect = 2e-31
Identities = 92/266 (34%), Positives = 138/266 (51%), Gaps = 20/266 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GEM---VAVKKLR----EKEETDIMH----L 56
E+ IT +G+G G V SG L+ G+ VA+K L+ EK+ D + +
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 728
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGM 115
+ +H NI+ GV ++ + I+ E+ + G L FL FT Q++ + I+ GM
Sbjct: 729 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 788
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+L+ NLV KVSDFG SR E D E+A + G + W APE
Sbjct: 789 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 848
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + DVWS+G+V+WE+++ E PY + ++ V E LP P CP +L
Sbjct: 849 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMDCPAAL 907
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + +RP F I+ LD
Sbjct: 908 YQLMLDCWQKERNSRPKFDEIVNMLD 933
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 138 bits (335), Expect = 2e-31
Identities = 87/263 (33%), Positives = 135/263 (51%), Gaps = 14/263 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGE--MVAVKKLREKEE------TDIMHLRK 58
++WE+ I LG G G VY G + +AVK L+E + ++
Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKD 361
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH--SGASFTPRQIIRWAKDIAQGMV 116
L+H N+VR GVC+ + II EF G L ++L + P +++ A IA GM
Sbjct: 362 LHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMS 421
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTGTVAWMAPEVIR 174
YL R IHRDL + N LV+++ + K++DFG +R + D +A + W APE +
Sbjct: 422 YLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLA 481
Query: 175 HEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVW+FGV+LWE+ T + PY +E + +G+ + P CP S+ L
Sbjct: 482 FNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNV-YGLLENGFRMDGPQGCPPSVYRL 540
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ QCW+ P +RP F+ I +L+
Sbjct: 541 MLQCWNWSPSDRPRFRDIHFNLE 563
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 138 bits (334), Expect = 3e-31
Identities = 95/270 (35%), Positives = 136/270 (50%), Gaps = 27/270 (10%)
Query: 11 VPFESITDMMYLGSGAQGVVYSGNL------RGEMVAVKKLREKEETD-----IMHLRKL 59
VPF + LGSGA GVV L +VAVK L+E T+ IM L+ L
Sbjct: 382 VPFHLLNLKDDLGSGAFGVVKKAELFDPISQTTSIVAVKMLKESASTEDEKDIIMELKVL 441
Query: 60 ----NHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQI---IRWAKD 110
H N+V F G +I+E+C+ G L FL S G +P + + A
Sbjct: 442 YHVGEHCNVVSFLGASVHKGKLHLIVEYCERGNLLQFLRSKRGDMKSPLSVQNQVAIASQ 501
Query: 111 IAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVAW 167
+A GM YL +++ IHRDL + NVL+ +L KV+DFG +R+ S+V +G + W
Sbjct: 502 VANGMAYLASKRCIHRDLAARNVLITKDLTLKVADFGLARKM--YSSVYRPSGKRLPIKW 559
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSC 226
MAPE I C+ + DVWSFG++LWE++T PY H ++ + +P P+ C
Sbjct: 560 MAPEGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDI-ENGYRMPQPDGC 618
Query: 227 PESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P+ L ++ CW P RP F + LD
Sbjct: 619 PDKLYSVMKCCWQMNPIARPEFTELTNSLD 648
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 138 bits (334), Expect = 3e-31
Identities = 106/347 (30%), Positives = 163/347 (46%), Gaps = 26/347 (7%)
Query: 24 SGAQGVVYSGNLRGEM-----VAVKKLREKEETDIMH--------LRKLNHDNIVRFRGV 70
SG G VY G LR VAVK L+ E + + +R L+H N++ GV
Sbjct: 180 SGNFGDVYRGKLRSRQNTWHDVAVKSLKSLENHEDVEKFLREGVMMRGLDHRNVLALIGV 239
Query: 71 CSEGE------NYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHNRKI 123
C +GE + II+ F + G L FL G + T +++++ KD+A GM YL +K
Sbjct: 240 CVDGEVERLQTSPLIILPFMENGDLRTFLRDGNNVLTVLKLLKFCKDVAMGMEYLAEKKF 299
Query: 124 IHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEPCSE 180
+HRDL + N +V N KV+DFG SR+ + S T + WM PE I++ E
Sbjct: 300 VHRDLAARNCMVDKNWCVKVADFGLSRDLFDRDYYRSSVKTQLPLKWMPPESIKYGRYGE 359
Query: 181 RVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWD 239
+ DVWS+G+V WE++T+ IPY T++ AIL + +E + P CP L + +CW
Sbjct: 360 KSDVWSYGIVCWEIMTRGAIPYPTVQAVAILQYL-SEGNRMERPECCPHKLYKTMEKCWL 418
Query: 240 RVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQA 299
RP F+ ++ + R + R ++ +N + KEK E +
Sbjct: 419 DDTERRPTFEELVTITTKIVRDARRSVKHRKHSCDSSSSAGSDNPLNPYQNSVKEKNENS 478
Query: 300 QKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEK 346
K + R LRL + R E + R + E++EK
Sbjct: 479 -KPKPKPRTSLRLKENERSDKYSAHQENKERRTDEMGERKKREKEEK 524
>UniRef50_A2EC73 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1061
Score = 138 bits (334), Expect = 3e-31
Identities = 84/255 (32%), Positives = 134/255 (52%), Gaps = 13/255 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKEET---------DIMHLRK 58
++P E I LG+G G VY GE++A+K++R T +I + K
Sbjct: 216 DIPTEDIALDDALGTGGFGTVYRSTRISTGELLAIKEVRNDRITMGTWASLYSEIATMAK 275
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA-SFTPRQIIRWAKDIAQGMVY 117
L + I+ G + + Y II FC L++ LH TP + + A +A G+ Y
Sbjct: 276 LKNRYILELVGTHIK-QPYRIITRFCPGKSLFERLHRPCVPLTPLHLTQIAYQMAVGIAY 334
Query: 118 LHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEP 177
LH+ I+HRDLK+ N+++ ++ A ++DFG DN ++ GT + APEV+ H+
Sbjct: 335 LHSLGIVHRDLKTLNIILDEDEAAIIADFGLCGFVDNNEGLVGGVGTPHYTAPEVLAHKR 394
Query: 178 CSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
+VD +SFG++LWE+ T +IPY+ I V T L +P+S P+ L+ L+ +C
Sbjct: 395 YGLKVDTYSFGIILWEMATNQIPYRDKTQAEIYSHVVTHGWHLKIPSSVPDGLRRLILRC 454
Query: 238 WDRVPRNRPPFKIIL 252
W P +RP F I+
Sbjct: 455 WSIDPNDRPDFDEIV 469
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 138 bits (333), Expect = 4e-31
Identities = 86/265 (32%), Positives = 137/265 (51%), Gaps = 14/265 (5%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE----KEE--TDIMHLRKLNH 61
WE+ E I + LGSG G V+ G +G VAVK ++E ++E + + KLNH
Sbjct: 365 WELKREEIVPLRELGSGQFGAVHLGKWKGLYDVAVKMIKEGVVSEDEFVEEAQTMMKLNH 424
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQGMVYLHN 120
+VR GVCS+ ++ME+ G L +L G P Q++ D+ M +L +
Sbjct: 425 PKLVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQPLQLLEICYDVCDAMAFLES 484
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMAPEVIRHEP 177
++IHRDL + N LV NL K+SDFG ++ + + +S GT V W APEV +
Sbjct: 485 CQLIHRDLAARNCLVDSNLTVKLSDFGMTK-YVLDDLYVSSLGTKFPVKWSAPEVFHYTK 543
Query: 178 CSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
S + DVW+FG+++WE+ T + PY+ + ++ V ++ L P + ++
Sbjct: 544 FSSKSDVWAFGILMWEVFTLGKQPYELYDNMQVIEKV-SQGYRLYRPQLVSDITYQIMYN 602
Query: 237 CWDRVPRNRPPFKIILAHLDIAGAE 261
CW +P RP F +L+ + A E
Sbjct: 603 CWHELPEKRPAFHQLLSFFEDAVEE 627
>UniRef50_A2DK06 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1030
Score = 138 bits (333), Expect = 4e-31
Identities = 90/258 (34%), Positives = 129/258 (50%), Gaps = 16/258 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGN--LRGEMVAVKKLREKEET---------DIMHLRK 58
EV + + +G GA VY + G + AVKK + T +I L +
Sbjct: 16 EVRLDEFKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAAEIHNFYREIKILSR 75
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYD--FLHSGA-SFTPRQIIRWAKDIAQGM 115
+ ++ F G+ S Y I M++ + G L+ F GA TP A IA GM
Sbjct: 76 ARNYFLIPFYGI-SFSSPYIIAMKYIKRGSLHSAIFHKEGAPQLTPTNKTIIAFCIASGM 134
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR-EWDNESAVMSFTGTVAWMAPEVIR 174
YLH +IHRDLKS NVL+ L + DFG SR + D++ + GT WMAPEV
Sbjct: 135 QYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISRVKSDSDQLMTKMIGTPHWMAPEVFS 194
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ +VD++SF ++LWEL+++E PYK ++ V T+ P+P C LK LL
Sbjct: 195 SNDYTNKVDIYSFAILLWELISEERPYKGYSAPQLIAAVCTKNERPPIPKKCTTKLKNLL 254
Query: 235 NQCWDRVPRNRPPFKIIL 252
QCW + P+ RP F I+
Sbjct: 255 TQCWHKNPKLRPTFADIM 272
>UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase BLK - Homo
sapiens (Human)
Length = 505
Score = 137 bits (332), Expect = 5e-31
Identities = 84/264 (31%), Positives = 144/264 (54%), Gaps = 14/264 (5%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL------R 57
++++WE+P +S+ + LGSG G V+ G + M VA+K L+E + L +
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGM 115
L H+ +VR V ++ Y I+ E+ G L DFL + G+ + ++I + IA+GM
Sbjct: 290 ALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNE-SAVMSFTGTVAWMAPEVIR 174
Y+ IHRDL++ N+LV++ L K++DFG +R D+E +A + W APE I
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH 408
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL-KL 232
+ + DVWSFGV+L E++T +PY + ++ + +P P++CP L +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRG 467
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW P RP F+ + + L+
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLE 491
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 137 bits (331), Expect = 7e-31
Identities = 95/291 (32%), Positives = 152/291 (52%), Gaps = 33/291 (11%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSG---NLRGEM---VAVKKLRE----KEETDIMH- 55
++WEVP + I + LG G+ G+VY G ++RG+ AVK + E +E + ++
Sbjct: 971 DEWEVPRKKIELIRELGQGSFGMVYEGIAQDVRGKAQIKCAVKTVNEHATNRERLEFLNE 1030
Query: 56 ---LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS----GASFTP------- 101
++ + ++VR GV S+G+ +IME G L +L S + P
Sbjct: 1031 ASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKTYLRSHRPDAEVYDPATAKQPP 1090
Query: 102 --RQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAV 158
+QI++ A +IA GM YL +K +HRDL + N +VA++L K+ DFG +R+ ++ +
Sbjct: 1091 TLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYR 1150
Query: 159 MSFTG--TVAWMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGT 215
G V WMAPE ++ + DVWS+GVVLWE+ T PY+ L +L V
Sbjct: 1151 KGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGLSNDQVLRYV-I 1209
Query: 216 ETILLPVPNSCPESLKLLLNQCWDRVPRNRPPF-KIILAHLDIAGAEFSRV 265
+ ++ P +CP+ L L+ CW P RP F K+ L+ A F++V
Sbjct: 1210 DGGVMERPENCPDKLYTLMRYCWQHKPSARPSFLKLCSLLLEDASTSFAQV 1260
>UniRef50_A7PBE5 Cluster: Chromosome chr16 scaffold_10, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr16 scaffold_10, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 1350
Score = 137 bits (331), Expect = 7e-31
Identities = 76/245 (31%), Positives = 131/245 (53%), Gaps = 15/245 (6%)
Query: 22 LGSGAQGVVYSGNLR--GEMVAVKKLRE--KEETDIMHLR-------KLNHDNIVRFRGV 70
+G G+ G VY G + G+ VA+K + + K E DI +LR KL H+NI+
Sbjct: 12 VGEGSFGKVYKGRRKFTGQTVAMKFILKHGKSEKDIQNLRQEIEILRKLKHENIIEMLDS 71
Query: 71 CSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKS 130
+ +C++ EF Q G L++ L Q+ AK + + + YLH+ +IIHRD+K
Sbjct: 72 FETPQEFCVVTEFAQ-GELFEILEDDKCLPEEQVQAIAKQLVRALHYLHSNRIIHRDMKP 130
Query: 131 PNVLVADNLVAKVSDFGTSREWDNESAVM-SFTGTVAWMAPEVIRHEPCSERVDVWSFGV 189
N+L+ + K+ DFG +R + V+ S GT +MAPE++R +P + D+WS GV
Sbjct: 131 QNILIGAGSIVKLCDFGFARAMSTNTVVLRSIKGTPLYMAPELVREQPYNHTADLWSLGV 190
Query: 190 VLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFK 249
+L+EL + P+ T +A++ + + + P++ + + L ++VP+NR +
Sbjct: 191 ILYELFVGQPPFYTNSVYALIRHIIKDPV--KYPDNMSANFRSFLKGLLNKVPQNRLTWP 248
Query: 250 IILAH 254
+L H
Sbjct: 249 ALLEH 253
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 137 bits (331), Expect = 7e-31
Identities = 99/272 (36%), Positives = 132/272 (48%), Gaps = 26/272 (9%)
Query: 11 VPFESITDMMY---LGSGAQGVVYSGNL---RGE--MVAVKKLRE----KEETDIMH--- 55
VP ++ D+ + LG GA G VY G L GE VAVK L+E K + D
Sbjct: 366 VPQYTLQDVRFVEELGEGAFGKVYKGELTQKNGERIFVAVKALKENASAKTQADFKREIE 425
Query: 56 -LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL-----HSGASFTPRQIIRWAK 109
+ L HDNIV GV + E C++ E+ G L++FL + G S + Q + A+
Sbjct: 426 LISDLKHDNIVCILGVVLKEEPLCMLFEYMAQGDLHEFLIANSPNEGKSLSQLQFLLIAQ 485
Query: 110 DIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE---WDNESAVMSFTGTVA 166
I GM YL + +HRDL + N LV DNL K+SDFG SR+ D V
Sbjct: 486 QICDGMEYLASHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYSSDYYRVQSKSLLPVR 545
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQEI-PYKTLETHAILWGVGTETILLPVPNS 225
WM E I + + DVWSFGVVLWE+ + + PY ++ V LLP P S
Sbjct: 546 WMPSESILYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQ-LLPCPES 604
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIILAHLDI 257
CP ++ L+ +CW RP F I L I
Sbjct: 605 CPSAVYSLMVECWHEQAVRRPTFPEIGHRLKI 636
>UniRef50_A7RN75 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 732
Score = 137 bits (331), Expect = 7e-31
Identities = 99/293 (33%), Positives = 141/293 (48%), Gaps = 26/293 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S +DWE+ + +GSG+ G VY GN G VA+K L + T ++
Sbjct: 424 STDDWEILEGEVQMGPRIGSGSYGTVYKGNWHGA-VAIKTLNVTDPTPTQLQAFKNEVAV 482
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQG 114
LRK H N++ F G C I+ ++C+ LY LH + F +I A+ AQG
Sbjct: 483 LRKTRHVNVLLFMG-CMSKPKLAIVTQWCEGSSLYRHLHVLENRFEVLNLIDIARQTAQG 541
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTS---REWDNESAVMSFTGTVAWMAPE 171
M YLH +KIIHRDLKS N+ + ++L K+ DFG + W +G++ WMA E
Sbjct: 542 MDYLHAKKIIHRDLKSNNIFLQEDLTVKIGDFGLATIKTRWSGSQYSEQPSGSILWMAAE 601
Query: 172 VIR---HEPCSERVDVWSFGVVLWELLTQEIPYKTL-ETHAILWGVGTETI---LLPVPN 224
VIR P S DV++FG+VL+ELL+ +PY + IL+ VG + + N
Sbjct: 602 VIRMLDPNPYSFHSDVYAFGIVLYELLSSSLPYAHVGNKDQILYMVGRGYLRPDMSKARN 661
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATW 277
P++ L +C RP F ILA L+ R LP T W
Sbjct: 662 DIPKAFNRLCLECIKFNRDERPLFPQILASLE----AIHRALPKIQRSTSEPW 710
>UniRef50_A7TJU8 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 977
Score = 137 bits (331), Expect = 7e-31
Identities = 82/242 (33%), Positives = 127/242 (52%), Gaps = 10/242 (4%)
Query: 22 LGSGAQGVVYSGNLR--GEMVAVKKLR---EKEETDIM---HLRK-LNHDNIVRFRGVCS 72
+G G+ GVVY R ++VA+K++ ++E DIM HL K LNH NIV++ G
Sbjct: 69 IGKGSFGVVYKAVNRKTNQVVAIKEVNYDNDEELNDIMSEIHLLKNLNHVNIVKYHGFIQ 128
Query: 73 EGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPN 132
+ + II+E+C G L + + + + QG+ YLH + +IHRD+KS N
Sbjct: 129 KMDTLYIILEYCSRGSLKKLISPNRGIPEIEAQSYIRQTLQGLSYLHEQGVIHRDIKSAN 188
Query: 133 VLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLW 192
+L+ + V K++DFG S + +N S M+ G++ WMAPE+I + S D+WS G +
Sbjct: 189 LLLDSSNVVKLADFGVSTKVNNASMAMTLAGSLNWMAPEIIGNRGASTLSDIWSLGATVV 248
Query: 193 ELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIIL 252
ELLT P+ L I + + +T LP N L+ C+ + RP K +L
Sbjct: 249 ELLTGNPPFHNLVDVNIYYAIENDT-YLPPENKVSHVAANFLSCCFQKNMYLRPTAKQLL 307
Query: 253 AH 254
H
Sbjct: 308 QH 309
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 137 bits (331), Expect = 7e-31
Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 13/265 (4%)
Query: 9 WEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLRE--KEETDIMHLRK----LNH 61
WE+ + +T + LG+G GVV G RG+ VA+K ++E E + + K L+H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGMVYLHN 120
+ +V+ GVC++ II E+ G L ++L F +Q++ KD+ + M YL +
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 514
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSREW--DNESAVMSFTGTVAWMAPEVIRHEPC 178
++ +HRDL + N LV D V KVSDFG SR D ++ + V W PEV+ +
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + D+W+FGV++WE+ + ++PY+ + + + L P+ E + ++ C
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSC 633
Query: 238 WDRVPRNRPPFKIILAH-LDIAGAE 261
W RP FKI+L++ LD+ E
Sbjct: 634 WHEKADERPTFKILLSNILDVMDEE 658
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 136 bits (330), Expect = 9e-31
Identities = 90/281 (32%), Positives = 139/281 (49%), Gaps = 23/281 (8%)
Query: 6 EEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMV--AVKKLREKE----------ETDI 53
E+DWE+ I + LG G+ G VY G ++ A+K + EK E +
Sbjct: 910 EDDWEIDRNDIEIIRELGKGSFGTVYEGLIKSRQYPCAIKTISEKSSISSKMEFLNEGSV 969
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS----GASFTPRQIIRWAK 109
M H ++++ G+ S G+ +IME + G L +L + T +I R A
Sbjct: 970 MKSFSETH-HVIKLLGIVSRGDRPFVIMELMERGDLKSYLRRCRGPSQNLTTNEIYRMAS 1028
Query: 110 DIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSRE-WDNESAVMSFTG--TVA 166
+IA GM YL +K +HRDL + N +VA + K+ DFG +R+ ++ + G +
Sbjct: 1029 EIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMARDIYETDYYRKGTAGLLPIR 1088
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNS 225
WMAPE + + DVWS+GVVLWE+ T E+PY+ L +L V T L +P
Sbjct: 1089 WMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGAEEVLQFV-TSGRTLDMPPQ 1147
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIILAHL-DIAGAEFSRV 265
C + L +++ CW P +RP F I+ L + G +F V
Sbjct: 1148 CSDLLHKIMSACWKWRPNDRPTFFSIVDELVNHVGEDFRLV 1188
>UniRef50_Q54L00 Cluster: Zn binding domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn binding
domain-containing protein - Dictyostelium discoideum AX4
Length = 650
Score = 136 bits (330), Expect = 9e-31
Identities = 90/247 (36%), Positives = 124/247 (50%), Gaps = 23/247 (9%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREK------EETD----IMHLRKLNHDNIVRFRGVC 71
+ SGA G VY G +G VA+K + EE D IM L +H N RF G
Sbjct: 392 IASGASGKVYKGIYKGRDVAIKVYSSENFCFNIEEFDREVTIMSLIDSDHPNFTRFYGAN 451
Query: 72 SEGENYCI-IMEFCQYGPLYDFLHSG----ASFTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
+ + Y + E + G L D L A FT I A DIA M +LH+ +IHR
Sbjct: 452 KQNKKYLFHVSELVKSGSLRDLLLDKEKPLAYFTQLSI---ASDIANAMKHLHSIGVIHR 508
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLKS NVL+ ++ AKV DFGTSR D + GT +M+PE+ + E DV++
Sbjct: 509 DLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNGYDETCDVYA 568
Query: 187 FGVVLWELLTQEIPYKTLETHAI--LWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRN 244
FG+VLWE++ ++ PY+ + + +I L G +P CP L+ CW P+
Sbjct: 569 FGIVLWEIIARKEPYENINSWSIPVLVAKGERP---TIPADCPSEYSKLIKACWTDKPKK 625
Query: 245 RPPFKII 251
RP FK I
Sbjct: 626 RPSFKEI 632
>UniRef50_A2F251 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 495
Score = 136 bits (330), Expect = 9e-31
Identities = 84/213 (39%), Positives = 119/213 (55%), Gaps = 7/213 (3%)
Query: 43 KKLRE-KEETDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--- 98
K ++E K+E +M L N+ +V F G ++ Y II F G +Y+ LHS S
Sbjct: 61 KTIKEYKQEIKVMSLS--NNFFVVPFVGFTTK-HPYTIITRFIPNGSVYEALHSTDSSKK 117
Query: 99 FTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAV 158
T Q A +A GM +LH+R IIHRDLKS NVL+ K+ DFG S + S +
Sbjct: 118 LTGTQKTIIALGVAAGMAHLHSRGIIHRDLKSLNVLLDSKTYPKICDFGLSHFDTDSSII 177
Query: 159 MSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETI 218
TGT MAPE+ +P + +VDV+S+G++L+ELLT +IP+ + + I+ V E
Sbjct: 178 DQNTGTPHLMAPELFESKPYTNKVDVYSYGILLYELLTSKIPFNGMTSLQIMNAVCIEKK 237
Query: 219 LLPVPNSCPESLKLLLNQCWDRVPRNRPPFKII 251
+P+S PE LK L+N CW + P RP F I
Sbjct: 238 RPKIPDSAPEKLKFLINLCWSQNPDFRPSFDSI 270
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 136 bits (330), Expect = 9e-31
Identities = 83/268 (30%), Positives = 137/268 (51%), Gaps = 14/268 (5%)
Query: 1 MLFLSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLR------EKEETDI 53
+L + E+WE+ I + LG+G G V+ G G VAVK L+ E+ +
Sbjct: 225 LLRQANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVEEFLQEA 284
Query: 54 MHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTP-RQIIRWAKDIA 112
+++L H +++ VC++ E I+ E +YG L ++L Q++ A +A
Sbjct: 285 SIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVA 344
Query: 113 QGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGT---VAWMA 169
GM YL + IHRDL + N+LV ++ + KV+DFG +R D E + TG + W A
Sbjct: 345 SGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVID-EEIYEAHTGAKFPIKWTA 403
Query: 170 PEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPE 228
PE + + + DVWSFGVVL+E++T PY + +L + + +P P +CP+
Sbjct: 404 PEAAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKI-QQNYRMPCPANCPK 462
Query: 229 SLKLLLNQCWDRVPRNRPPFKIILAHLD 256
++ CW P +RP F+ + L+
Sbjct: 463 QFHDIMLDCWREDPASRPTFETLQWQLE 490
>UniRef50_UPI0000498E32 Cluster: protein kinase; n=2; Entamoeba
histolytica HM-1:IMSS|Rep: protein kinase - Entamoeba
histolytica HM-1:IMSS
Length = 951
Score = 136 bits (329), Expect = 1e-30
Identities = 84/264 (31%), Positives = 139/264 (52%), Gaps = 22/264 (8%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEETDIMH 55
S + ++ +E +G G+ G+V+ G RG VA+K+ + E ++
Sbjct: 579 SAKSIKLDYEEFEKTKVIGEGSFGIVFLGKYRGVDVAIKQTKNFTWPEDVVEAFRKEVQM 638
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGM 115
+ K+ I+ F G Y I+ E+ ++G L + ++ FT ++ D+A+GM
Sbjct: 639 MDKMRCPYIINFIGAVDTPGYYSIVTEYAKFGSLKN-VYENEKFTQLLGLKMLTDVAKGM 697
Query: 116 VYLHNRKIIHRDLKSPNVLVA-----DNLVAKVSDFGTSREWDNESAVMSFT---GTVAW 167
+LH IIHRDLK NVLV + + AK+SDFGTSR+ + + V S T GT +
Sbjct: 698 TFLHASMIIHRDLKPENVLVVSMVKKEKINAKLSDFGTSRDVSSSNVVASMTQGIGTPLY 757
Query: 168 MAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVG---TETILLPVPN 224
MAPE++ ++ + VDV+S+ +V +E+L++++PY E A W V T+ L +P+
Sbjct: 758 MAPELLLNQGYGQAVDVFSYAIVCYEVLSRKVPYSD-ENFAHSWDVSDFVTKGNRLNIPD 816
Query: 225 SCPESLKLLLNQCWDRVPRNRPPF 248
S P + L++ CW P RP F
Sbjct: 817 SFPPEMAKLISDCWAEDPNLRPKF 840
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 136 bits (329), Expect = 1e-30
Identities = 89/263 (33%), Positives = 138/263 (52%), Gaps = 17/263 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSG--NLRGEMV--AVK--------KLREKEETDIMHLR 57
E+P + I + +G G G VY G N R V AVK K+R+ T+ +
Sbjct: 529 EIPPKYIKLVEEIGGGEFGTVYKGMWNERKPPVPIAVKTLKPGSSDKMRDDFLTEASIMG 588
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL-HSGASFTPRQIIRWAKDIAQGMV 116
+ +H N+++ GV ++ E IIMEF G LY +L H+ + +Q+++ A +A GM
Sbjct: 589 QFHHPNVIKLYGVITKVEPAMIIMEFMDNGSLYYYLRHNDEKLSLQQLLKMACGVAAGMQ 648
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPEVIR 174
YL +HRDL + N+LV+ + V KV+DFG SRE N+ + G V W APE I
Sbjct: 649 YLSEVGYVHRDLAARNILVSKDEVCKVADFGLSRETTNDEYDVKKGGKIPVRWTAPEAIS 708
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
+ + DVWS+GV+LWE+++ + PY+ + +L + L P CP ++ L
Sbjct: 709 YRKFTTASDVWSYGVLLWEVMSYGQQPYEDWDNQMVLDKL-ESGYRLQKPKDCPSTVYEL 767
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW +RP FK ++ LD
Sbjct: 768 MQSCWSAEHTDRPTFKELVRLLD 790
>UniRef50_Q55EI8 Cluster: Filamin/ABP280 repeat-containing protein;
n=1; Dictyostelium discoideum AX4|Rep: Filamin/ABP280
repeat-containing protein - Dictyostelium discoideum AX4
Length = 1385
Score = 136 bits (329), Expect = 1e-30
Identities = 80/245 (32%), Positives = 130/245 (53%), Gaps = 12/245 (4%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKE--------ETDIMHLRKLNHDNIVRFRGVCSE 73
+G G GVV G +G +AVK+ E+E ++ + L HDNIV G ++
Sbjct: 764 IGRGVSGVVKRGKWKGYEIAVKQFNEEELGFSEREFHSEATIMSVLRHDNIVHCVGGSAQ 823
Query: 74 GENYCIIMEFCQYGPLYDFLHSG-ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPN 132
++ ++ G LY + + + +I+ A +A+GM YLH+ IIHRDLK N
Sbjct: 824 PGKMYLVCDYYSRGSLYSVITANICPLSNARIVHLALQVAKGMNYLHSLGIIHRDLKPGN 883
Query: 133 VLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRH-EPCSERVDVWSFGVVL 191
+L+ + ++SDFG SR DN + GT +MA EV++ S++ DV+SF VL
Sbjct: 884 LLIDQDWNIRISDFGLSRVVDNR--MTKTVGTPCYMAVEVLKGLTDYSQQADVYSFAFVL 941
Query: 192 WELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKII 251
WE ++++IPYK + V ++ P+P+SC + L+ CW P +RP F+ I
Sbjct: 942 WECISRQIPYKDFAQIQWISMVLEDSFRPPIPDSCLPEFRDLITMCWTSNPDDRPSFQQI 1001
Query: 252 LAHLD 256
+ +L+
Sbjct: 1002 ITYLE 1006
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 136 bits (328), Expect = 2e-30
Identities = 91/265 (34%), Positives = 129/265 (48%), Gaps = 20/265 (7%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLR--GE---MVAVKKLREKEET--------DIMHL 56
E+ +T +G G G VY G+LR G+ +VA+K L+ + +
Sbjct: 610 ELDVSCVTMENVIGEGEFGEVYRGSLRLPGKERIVVAIKTLKSTYSDSQWWNFLREATIM 669
Query: 57 RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS-FTPRQIIRWAKDIAQGM 115
+ NH NIV GV ++ II E+ + G L FL F+P Q++ + IA GM
Sbjct: 670 GQFNHPNIVHLEGVVTKRRPMMIITEYMENGALDTFLRENEEKFSPVQLVNMLQGIASGM 729
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL +HRDL + N+LV +L KVSDFG SR E D E + G + W APE
Sbjct: 730 TYLSEHNYVHRDLAARNILVTRSLQCKVSDFGLSRILENDAEGTYETKGGKIPIRWTAPE 789
Query: 172 VIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I H + DVWSFG+V+WE+L+ + PY + ++ + + LP P CP L
Sbjct: 790 AIAHRIFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSL-EDGYRLPPPVDCPSIL 848
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHL 255
L+ CW RP F+ I A L
Sbjct: 849 YELMKSCWSHDRMRRPHFQEIRAQL 873
>UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 276
Score = 136 bits (328), Expect = 2e-30
Identities = 90/259 (34%), Positives = 135/259 (52%), Gaps = 24/259 (9%)
Query: 20 MYLGSGAQGVVYSGNLRGEM-----VAVKKLR------EKEE--TDIMHLRKLN-HDNIV 65
M LG GA G V+ G LRG VAVK+L+ E+EE +I ++ + HDNIV
Sbjct: 1 MLLGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIV 60
Query: 66 RFRGVCSEGENYCIIMEFCQYGPLYDFLH-------SGASFTPRQIIRWAKDIAQGMVYL 118
G C + + C+IME+ YG L +L S ++ ++ + + IA GM +L
Sbjct: 61 TMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHL 120
Query: 119 HNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPC 178
+ IIHRDL + N+LV V K+SDFG SR + + W++PE I+
Sbjct: 121 ESVGIIHRDLAARNILVGTGKVLKISDFGMSRP-GVYIKMSKGVIPLRWLSPEAIKDNTY 179
Query: 179 SERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQC 237
S + DVW+FGV+LWE+ T PY + IL + TE + L P C + + +L+ C
Sbjct: 180 SNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQL-TEGMRLEQPAKCSDDMYILMKSC 238
Query: 238 WDRVPRNRPPFKIILAHLD 256
W+ +RP F IL+ ++
Sbjct: 239 WNLKAEDRPSFLAILSKIE 257
>UniRef50_Q9BI25 Cluster: SHK1 protein; n=2; Dictyostelium
discoideum|Rep: SHK1 protein - Dictyostelium discoideum
(Slime mold)
Length = 527
Score = 135 bits (327), Expect = 2e-30
Identities = 93/263 (35%), Positives = 135/263 (51%), Gaps = 16/263 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK----KLREKEETD----IMHLRKLNH 61
E+ IT LG G+ G VY G + + V VK ++ +K TD + + K+ H
Sbjct: 39 EISETEITTESILGDGSFGTVYKGRCKLKDVPVKVMLKQVDQKTLTDFRKEVAIMSKIFH 98
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQI-IRWAKDIAQGMVYLH- 119
NIV F G C+ +I G L L P +R AKD A G+++LH
Sbjct: 99 PNIVLFLGACTSTPGKLMICTELMKGNLESLLLDPMVKLPLITRMRMAKDAALGVLWLHS 158
Query: 120 -NRKIIHRDLKSPNVLVADNLVAKVSDFGTSR---EWDN-ESAVMSFTGTVAWMAPEVIR 174
N IHRDLK+ N+LV NL KV DFG S+ +N + GT WMAPEV++
Sbjct: 159 SNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQ 218
Query: 175 HEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLP-VPNSCPESLKLL 233
+E+ DV+SFG+VLW++ T++ + + E L P +P+ CP+SLK L
Sbjct: 219 GRLFNEKADVYSFGLVLWQIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKEL 278
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ +CWD P RP F+ I++ L+
Sbjct: 279 IQKCWDPNPEVRPSFEGIVSELE 301
>UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1;
Schistosoma mansoni|Rep: Fes-like tyrosine kinase protein
- Schistosoma mansoni (Blood fluke)
Length = 1259
Score = 135 bits (327), Expect = 2e-30
Identities = 86/267 (32%), Positives = 131/267 (49%), Gaps = 15/267 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR-EKEETDIMH------- 55
+S DWE+ + + +G G G VY G G VAVK R + +D+
Sbjct: 949 ISRPDWELDNRDVQLLQKIGQGNFGDVYRGVYNGCEVAVKTCRVDMTASDLRRKFLQGET 1008
Query: 56 -LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTP-RQIIRWAKDIAQ 113
NH NIV+ G+ + I+ME+ G L + L + P ++++ + D A
Sbjct: 1009 TALNFNHPNIVKLVGIAVQSYPIMIVMEYVPGGSLLNHLRKSKNALPVMKLLQMSLDAAN 1068
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPE 171
GM+YL R IHRDL + N L++D+ K++DFG SRE ++ + G + W APE
Sbjct: 1069 GMMYLEARNCIHRDLAARNCLISDDGQLKIADFGMSRE-EHIYELSDKRGQIPIKWTAPE 1127
Query: 172 VIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+R + + DVWS+GV+LWE+ T ++PY+ + LP P+ P L
Sbjct: 1128 ALRTGRYTIKCDVWSYGVLLWEIFTFGDVPYRNWSNQQTR-DMIESGYRLPAPDLMPVWL 1186
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLDI 257
+ L+N CW P NRP F I + I
Sbjct: 1187 RTLMNHCWHDEPMNRPSFSKISNEIQI 1213
>UniRef50_A2FEP9 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 1089
Score = 135 bits (327), Expect = 2e-30
Identities = 81/257 (31%), Positives = 134/257 (52%), Gaps = 14/257 (5%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNL--RGEMVAVKKLREKE---------ETDIMHLRK 58
++P E I LGSG G V+ G GE++AVK++R + +++ ++
Sbjct: 214 DIPCEDIIVGKTLGSGGFGTVFMGTRISTGELIAVKEVRSDKLSISTWASLYSEVANMAN 273
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGAS--FTPRQIIRWAKDIAQGMV 116
L + ++ G + E Y II FC L+D +H P ++ A +A GM
Sbjct: 274 LKNRYVLELVGAHIK-EPYRIITRFCPGRSLFDRIHRCPQHPLPPARLTALAYQVASGMA 332
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHE 176
+LH+ I+HRDLK+ N+L+ ++ A+++DFG S + + GT + APEV+ +
Sbjct: 333 FLHSNGIVHRDLKTMNILLDESDAARIADFGLSGNMRDNKDLYGTLGTPHYTAPEVLARK 392
Query: 177 PCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQ 236
+VD +SFG+VLWE+ T IP++ I+ V LP+ + P+SL+ L+ +
Sbjct: 393 RYGPKVDSYSFGIVLWEMETGLIPFREKTHKEIIDHVVNRGWRLPLSRTVPDSLRRLITR 452
Query: 237 CWDRVPRNRPPFKIILA 253
CW P RP F+ I+A
Sbjct: 453 CWSENPAERPEFEEIVA 469
>UniRef50_Q8LCP3 Cluster: ATMRK1; n=27; Magnoliophyta|Rep: ATMRK1 -
Arabidopsis thaliana (Mouse-ear cress)
Length = 391
Score = 135 bits (326), Expect = 3e-30
Identities = 89/306 (29%), Positives = 145/306 (47%), Gaps = 42/306 (13%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVK----------------KLREKEE 50
++WE+ + L G G VY G G+ VAVK LR E
Sbjct: 74 QEWEIDLSKLDMKHVLAHGTYGTVYRGVYAGQEVAVKVLDWGEDGYATPAETTTLRASFE 133
Query: 51 TDIMHLRKLNHDNIVRFRG---------VCSEGEN------------YCIIMEFCQYGPL 89
++ +KL+H N+ +F G + G+ C+++E+ G L
Sbjct: 134 QEVAVWQKLDHPNVTKFIGASMGTSDLRIPPAGDTGGRGNGAHPARACCVVVEYVAGGTL 193
Query: 90 YDFLHSG--ASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG 147
FL A + +I+ A D+A+G+ YLH++ I+HRD+KS N+L+ N K++DFG
Sbjct: 194 KKFLIKKYRAKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLQPNKTLKIADFG 253
Query: 148 TSR-EWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLET 206
+R E N + TGT+ +MAPEV+ +P + + DV+SFGV LWE+ ++PY
Sbjct: 254 VARVEAQNPQDMTGGTGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSF 313
Query: 207 HAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAE--FSR 264
I V + +P CP ++ ++ +CWD P RP + ++ L+
Sbjct: 314 AEISHAVVHRNLRPEIPKCCPHAVANIMKRCWDPNPDRRPEMEEVVKLLEAIDTSKGGGM 373
Query: 265 VLPDRF 270
+ PD+F
Sbjct: 374 IAPDQF 379
>UniRef50_A7Q6K4 Cluster: Chromosome chr11 scaffold_56, whole genome
shotgun sequence; n=40; Eukaryota|Rep: Chromosome chr11
scaffold_56, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 1063
Score = 135 bits (326), Expect = 3e-30
Identities = 85/262 (32%), Positives = 129/262 (49%), Gaps = 24/262 (9%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEET------DIMHLRK 58
+ + ++ LGSG G VY G +G VA+K+++ E+E + + L
Sbjct: 788 DDLEEIRELGSGTYGAVYHGKWKGSDVAIKRIKASCFAGRPSERERLIADFWKEALILSS 847
Query: 59 LNHDNIVRFRGVCSEGE--NYCIIMEFCQYGPLYDFLHSGASFTPRQIIRW-AKDIAQGM 115
L+H N+V F G+ +G + + EF G L FL R+ R A D + GM
Sbjct: 848 LHHPNVVSFYGIVRDGPGGSLATVTEFMVNGSLKQFLQKKDRTIDRRKRRIIAMDASFGM 907
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH + I+H DLK N+LV V K+ D G S+ + GT+ WMAPE
Sbjct: 908 EYLHGKNIVHFDLKCENLLVNMRDPHRPVCKIGDLGLSKVKQHTLVSGGVRGTLPWMAPE 967
Query: 172 VI--RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ + +E++DV+SFG+V+WELLT + PY + +I+ G+ T+ +P C
Sbjct: 968 LLSGKTNMVTEKIDVYSFGIVMWELLTGDEPYADMHCASIIGGIVNNTLRPQIPRWCEPE 1027
Query: 230 LKLLLNQCWDRVPRNRPPFKII 251
K L+ CW P RP F I
Sbjct: 1028 WKYLMESCWASDPAERPSFSEI 1049
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 135 bits (326), Expect = 3e-30
Identities = 89/264 (33%), Positives = 130/264 (49%), Gaps = 18/264 (6%)
Query: 10 EVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR----EKEETDIMH----LRKLNH 61
E+ F+ + +G G G V G + VA+K L+ +E +D + + + +H
Sbjct: 640 EIDFKLVNIEQVIGRGEFGEVCKGTFFNKCVAIKTLKVGYNTQERSDFLGEASIMGQFDH 699
Query: 62 DNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPR-QIIRWAKDIAQGMVYLHN 120
N++R GV ++ II EF + G L FL + P Q+ IAQGM YL N
Sbjct: 700 PNVIRLEGVVTKSRPLMIITEFMENGSLDAFLRNQEGKIPSAQLTEMLLSIAQGMEYLSN 759
Query: 121 RKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG-----TVAWMAPEVI 173
+HRDL + N+LV NLV KVSDFG SR E E V +T + W +PE I
Sbjct: 760 MGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEQLEEDDVAMYTTRGGMIPIRWTSPEAI 819
Query: 174 RHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKL 232
S DVWSFG+V+WE+++ E PY + ++ V + LP P CP +
Sbjct: 820 TMRTFSTSSDVWSFGIVMWEVMSFGERPYWEMSNQDVVQFVDS-GYRLPPPCYCPRIIHS 878
Query: 233 LLNQCWDRVPRNRPPFKIILAHLD 256
++ +CW R RP F ++ LD
Sbjct: 879 VMLECWKRDRTQRPNFSHLVTLLD 902
>UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1048
Score = 135 bits (326), Expect = 3e-30
Identities = 75/206 (36%), Positives = 114/206 (55%), Gaps = 9/206 (4%)
Query: 58 KLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFL--HSGASFTPRQIIRWAKDIAQGM 115
+ +H N++R GV ++ + + II E+ + G L FL H G FT Q++ ++IA GM
Sbjct: 699 QFDHPNVIRLEGVVTKSQPHMIITEYMENGSLDTFLRKHDG-EFTVIQLVGILRNIAAGM 757
Query: 116 VYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSR--EWDNESAVMSFTG--TVAWMAPE 171
YL + +HRDL + N+LV L+ KVSDFG SR E ++S + G + W APE
Sbjct: 758 KYLSDMGYVHRDLAARNILVNAQLICKVSDFGLSRVLEESSDSTYTTRGGKIPIRWTAPE 817
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
I + + DVWS+G+V+WE+++ E PY + ++ VGT LP P CP+
Sbjct: 818 AINYRKFTSASDVWSYGIVMWEVMSYGERPYWGMSNQDVIHAVGT-GYRLPAPMDCPQVQ 876
Query: 231 KLLLNQCWDRVPRNRPPFKIILAHLD 256
L+ CW + RP F ++A LD
Sbjct: 877 HELMLDCWKKDRNERPKFSQVVATLD 902
>UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11;
Mammalia|Rep: Tyrosine-protein kinase 6 - Homo sapiens
(Human)
Length = 451
Score = 135 bits (326), Expect = 3e-30
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 15/262 (5%)
Query: 7 EDWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKL-------REKEETDIMHLRK 58
+DWE P E T LGSG G V+ G + + VA+K + ++ +++I ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTP-RQIIRWAKDIAQGMV 116
L H +I+ V S G+ II E G L + L S P +++ A +A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL ++ IHRDL + N+LV +N + KV DFG +R E +S + W APE +
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
S + DVWSFG++L E+ ++ ++PY + H V +P P CP S+ L
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDA-GYRMPCPLECPPSVHKL 419
Query: 234 LNQCWDRVPRNRPPFKIILAHL 255
+ CW R P RP FK + L
Sbjct: 420 MLTCWCRDPEQRPCFKALRERL 441
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 134 bits (325), Expect = 4e-30
Identities = 83/261 (31%), Positives = 130/261 (49%), Gaps = 15/261 (5%)
Query: 4 LSEEDWEVPFESITDMMYLGSGAQGVVYSGNLRG--EMVAVKKLR----EKEETDIMH-- 55
+ E WE+ + + + +G G G VY L+ ++VAVK R E + +
Sbjct: 527 IPRERWELNNDDVVLLDKIGRGNFGDVYRAQLKNSNDVVAVKTCRVTLPEDHKKKFLQEG 586
Query: 56 --LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQ 113
L++ +H NIV+ G+C + + I+ME G L FL + T Q+++ D A
Sbjct: 587 RILKQYDHPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLRKKTALTDAQLMKMCLDAAA 646
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPE 171
GM YL ++ IHRDL + N LV N V K+SDFG SRE + E V + W APE
Sbjct: 647 GMRYLESKNCIHRDLAARNCLVGYNNVVKISDFGMSRE-EEEYIVSDGMKQIPIKWTAPE 705
Query: 172 VIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ + DVWS+G++ WE+ ++ PY L + +P P++ P+ +
Sbjct: 706 ALNFGKYTSLCDVWSYGILCWEIFSRGGTPYSGLSNSKAREKIDA-GYRMPAPDNTPDEM 764
Query: 231 KLLLNQCWDRVPRNRPPFKII 251
L+ +CW+ P NRP F+ I
Sbjct: 765 YRLMLRCWEYKPENRPNFEQI 785
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 134 bits (324), Expect = 5e-30
Identities = 85/261 (32%), Positives = 133/261 (50%), Gaps = 14/261 (5%)
Query: 4 LSEEDWEVPFESITDM-MYLGSGAQGVVYSGNLRGEM-VAVKKLREKEETDIMHL----- 56
L ++ WE P +S+ M LG G G V+ G G VAVK L+E+ + L
Sbjct: 113 LGKDKWETPRKSLGQMNRRLGEGKFGEVWQGVWNGNTPVAVKTLKERTMSPAAFLAEANV 172
Query: 57 -RKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQ--IIRWAKDIAQ 113
+KL H+ IV+ VCS+ E I+ E G L +L S + +I IA
Sbjct: 173 MKKLRHEGIVQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGAHIAS 232
Query: 114 GMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG--TVAWMAPE 171
GM YL ++ ++HRDL + NVLV V K++DFG ++ + + V + W APE
Sbjct: 233 GMDYLGSKNVVHRDLAARNVLVGKGNVVKIADFGRAQLMEKDVYVGEEGAKLPLKWTAPE 292
Query: 172 VIRHEPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESL 230
+ H + + DVWSFG+++ E++T PYK + T + V +P + C +SL
Sbjct: 293 AVLHGRFTIKSDVWSFGILMTEMVTFGGYPYKKMRTREVTKKV-ANGYRMPKMDHCTDSL 351
Query: 231 KLLLNQCWDRVPRNRPPFKII 251
+++ +CW + P+ RP FK +
Sbjct: 352 YMIMLKCWHKDPQQRPTFKYL 372
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 134 bits (324), Expect = 5e-30
Identities = 75/211 (35%), Positives = 111/211 (52%), Gaps = 6/211 (2%)
Query: 51 TDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAK 109
T+ + + +H N++ +GV + II E+ + G L FL + F Q+I +
Sbjct: 791 TEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLR 850
Query: 110 DIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTG---TVA 166
IA GM YL + +HRDL + NVLV L+ K++DFG SRE +N S + G V
Sbjct: 851 GIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVR 910
Query: 167 WMAPEVIRHEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNS 225
W APE I + DVWS+GVVLWE+++ E PY ++ + + LP P
Sbjct: 911 WTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSI-EKGYRLPAPMD 969
Query: 226 CPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
CPE+L L+ CW + +RP F I++ LD
Sbjct: 970 CPEALYQLMLDCWQKQRTHRPTFASIVSTLD 1000
>UniRef50_Q6A1B3 Cluster: Raf serine/threonine kinase; n=1;
Echinococcus multilocularis|Rep: Raf serine/threonine
kinase - Echinococcus multilocularis
Length = 780
Score = 134 bits (324), Expect = 5e-30
Identities = 94/272 (34%), Positives = 148/272 (54%), Gaps = 26/272 (9%)
Query: 5 SEEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEET---------DIMH 55
S + WE+P E I +GSG+ G V+ G G+ VA+K+L + T ++
Sbjct: 450 SSDKWEIPAEEIQRGPRIGSGSFGTVFKGYWHGD-VAIKELNVVDPTATQLKAFKNEVNV 508
Query: 56 LRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLH-SGASFTPRQIIRWAKDIAQG 114
LRK +H NI+ F GV S+ II ++C+ LY +H F +++ A+ QG
Sbjct: 509 LRKTSHANILLFMGVVSK-PRLAIITQWCEGSSLYKHIHVHERHFDVEEMVDVARQTTQG 567
Query: 115 MVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFG--TSREWDNESAVMSFTGTVAWMAPEV 172
M YLH +KI+HRDLKS N+ + + +V K+ DFG T + W S TG++ WMAPEV
Sbjct: 568 MDYLHAKKILHRDLKSSNIFLHERIV-KIGDFGLATMKTWKGGS--RQPTGSIFWMAPEV 624
Query: 173 IRHE---PCSERVDVWSFGVVLWELLTQEIPYKTLET-HAILWGVGTETILLP----VPN 224
+R E P + DV++FG+VL+EL+T ++P++ + IL+ VG + IL P + +
Sbjct: 625 MRMEGETPYTNLSDVYAFGIVLYELITGQLPFRGHNSREQILFLVG-KGILRPDMSAIRS 683
Query: 225 SCPESLKLLLNQCWDRVPRNRPPFKIILAHLD 256
P L+ ++ + + RP F + LD
Sbjct: 684 DVPTELRRVVIESCEFSRDARPNFSQLHQRLD 715
>UniRef50_A5DTE9 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 1165
Score = 134 bits (324), Expect = 5e-30
Identities = 76/244 (31%), Positives = 130/244 (53%), Gaps = 14/244 (5%)
Query: 22 LGSGAQGVVYSGN--LRGEMVAVKKLREKEETDIMH-------LRKLNHDNIVRFRGVCS 72
+G+GA VY L GE+VA+K++R ++ D+ L+ L H NIV++ G
Sbjct: 220 IGNGAFASVYRARNKLTGEVVAIKQIRLEQGQDVSAAMGEIDLLKILKHPNIVKYHGFAK 279
Query: 73 EGENYCIIMEFCQYGPLYD-FLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSP 131
+ +++EFC+ G L + G F+ ++ + K I G+ YLH++ ++HRD+K+
Sbjct: 280 NSTTFNLVLEFCEGGSLRQLYKRKGKGFSEAKVKYYVKGILHGLAYLHSQGVVHRDVKAS 339
Query: 132 NVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE-VIRHEPCSERVDVWSFGVV 190
NVL+ + K++DFG + +++ + GT WMAPE ++ + D+WS G
Sbjct: 340 NVLLTSSNDVKLADFGVAARENSQHHTV--VGTPNWMAPETILGGDGLCTSSDIWSLGAT 397
Query: 191 LWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKI 250
+ ELLT PY L A L +GT+ P+P ++L+ L +C+ + P R K+
Sbjct: 398 IIELLTTNPPYHDLNPMAALHAIGTDE-YPPLPKGISQALRDFLLECFQKQPNLRISAKL 456
Query: 251 ILAH 254
+L H
Sbjct: 457 LLNH 460
>UniRef50_P18160 Cluster: Non-receptor tyrosine kinase spore lysis A;
n=2; Dictyostelium discoideum|Rep: Non-receptor tyrosine
kinase spore lysis A - Dictyostelium discoideum (Slime
mold)
Length = 1584
Score = 134 bits (324), Expect = 5e-30
Identities = 93/279 (33%), Positives = 145/279 (51%), Gaps = 31/279 (11%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKL-REKEET---------DIMHLR 57
++E+ F + +G G G V G R VA+K + R++ +T ++ L
Sbjct: 1281 EYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVMFQNEVGILS 1340
Query: 58 KLNHDNIVRFRGVCSEG--ENYCIIMEFCQYGPLYDFLHSGASF---TPRQIIRWAKDIA 112
KL H N+V+F G C+ G +++CI+ E+ G L FL + P ++ A DIA
Sbjct: 1341 KLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIA 1400
Query: 113 QGMVYLHN--RKIIHRDLKSPNVLVADNL-------------VAKVSDFGTSR-EWDNES 156
+GM YLH I+HRDL S N+L+ N+ K+SDFG SR + + S
Sbjct: 1401 KGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQAS 1460
Query: 157 AVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTE 216
+ G + +MAPEV + + SE+ DV+S+G+VL+ELLT + P + ++ + E
Sbjct: 1461 QMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYE 1520
Query: 217 TILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHL 255
+ P+P + K +L QCWD P +RP FK I+ HL
Sbjct: 1521 SYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHL 1559
>UniRef50_Q9FKL3 Cluster: Similarity to protein kinase; n=1;
Arabidopsis thaliana|Rep: Similarity to protein kinase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 1054
Score = 134 bits (323), Expect = 6e-30
Identities = 83/259 (32%), Positives = 127/259 (49%), Gaps = 24/259 (9%)
Query: 14 ESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLR---------EKEET------DIMHLRK 58
+ + ++ LG G G VY G +G VA+K+++ E+E + + L
Sbjct: 779 DDLEEIRELGHGTYGSVYHGKWKGSDVAIKRIKASCFAGKPSERERLIEDFWKEALLLSS 838
Query: 59 LNHDNIVRFRGVCSEGENYCI--IMEFCQYGPLYDFLHS-GASFTPRQIIRWAKDIAQGM 115
L+H N+V F G+ +G + + + EF G L FL + R+ + A D A GM
Sbjct: 839 LHHPNVVSFYGIVRDGPDGSLATVAEFMVNGSLKQFLQKKDRTIDRRKRLIIAMDTAFGM 898
Query: 116 VYLHNRKIIHRDLKSPNVLV----ADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPE 171
YLH + I+H DLK N+LV + K+ D G S+ GT+ WMAPE
Sbjct: 899 EYLHGKNIVHFDLKCENLLVNMRDPQRPICKIGDLGLSKVKQKTLVSGGVRGTLPWMAPE 958
Query: 172 VI--RHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPES 229
++ + SE++DV+SFG+V+WELLT E PY + +I+ G+ + +P C
Sbjct: 959 LLSGKSNMVSEKIDVYSFGIVMWELLTGEEPYADMHCASIIGGIVNNALRPKIPQWCDPE 1018
Query: 230 LKLLLNQCWDRVPRNRPPF 248
K L+ CW P RP F
Sbjct: 1019 WKGLMESCWTSEPTERPSF 1037
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 134 bits (323), Expect = 6e-30
Identities = 71/201 (35%), Positives = 115/201 (57%), Gaps = 5/201 (2%)
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGA--SFTPRQIIRWAKDIAQGMV 116
L+H N+V GV + N +I E+ G L D L S + RQ++ +A DI QGM
Sbjct: 333 LSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMC 392
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNES-AVMSFTGTVAWMAPEVIRH 175
YL +++I+HRDL + NVL+ D+LVAKVSDFG +++ +++S S + W APE +RH
Sbjct: 393 YLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRH 452
Query: 176 EPCSERVDVWSFGVVLWELLT-QEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLL 234
+ + DVWSFG++LWE+ + +PY + ++ + + + P CP + ++
Sbjct: 453 SQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYI-EKGYRMEAPEGCPPEIFKVM 511
Query: 235 NQCWDRVPRNRPPFKIILAHL 255
N+ W ++RP F +L L
Sbjct: 512 NETWALSAQDRPSFGQVLQRL 532
>UniRef50_Q54L02 Cluster: LIM domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: LIM domain-containing
protein - Dictyostelium discoideum AX4
Length = 874
Score = 134 bits (323), Expect = 6e-30
Identities = 85/245 (34%), Positives = 121/245 (49%), Gaps = 19/245 (7%)
Query: 22 LGSGAQGVVYSGNLRGEMVAVKKLREKE----------ETDIMHLRKLNHDNIVRFRGVC 71
+ +GA G VY G +G VA+K + E IM L +H N RF G
Sbjct: 616 IAAGASGKVYKGIYKGRDVAIKVYSSENFCFNIDEFDREVTIMSLIDSDHPNFTRFYGAN 675
Query: 72 SEGENYCI-IMEFCQYGPLYDFLHSGAS----FTPRQIIRWAKDIAQGMVYLHNRKIIHR 126
+ + Y + E + G L D L FT I A DIA M +LH+ +IHR
Sbjct: 676 KQNKKYLFHVSELVKSGSLRDLLLDKEKPLLYFTQLSI---ASDIANAMKHLHSIGVIHR 732
Query: 127 DLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
DLKS NVL+ ++ AKV DFGTSR D + GT +M+PE+ + E DV++
Sbjct: 733 DLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDVYA 792
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRP 246
FG+VLWE++ ++ PY+ + + +I V + +P CP L+ CW P+ RP
Sbjct: 793 FGIVLWEIIARKEPYENINSWSIPVMV-AKGDRPTIPADCPSEYSKLIKACWTDKPKKRP 851
Query: 247 PFKII 251
FK I
Sbjct: 852 SFKEI 856
>UniRef50_A2DNM3 Cluster: TKL family protein kinase; n=1;
Trichomonas vaginalis G3|Rep: TKL family protein kinase
- Trichomonas vaginalis G3
Length = 787
Score = 134 bits (323), Expect = 6e-30
Identities = 97/336 (28%), Positives = 165/336 (49%), Gaps = 33/336 (9%)
Query: 22 LGSGAQGVVYSG--NLRGEMVAVKK------------LREKEETDIMHLRKLNHDNIVRF 67
+G G GVV+ G N ++VA+KK + ++E + L ++ H IV F
Sbjct: 210 IGFGITGVVFKGINNRTNKLVAIKKFSLSSFNTARFQIYQREVSVFSRLAEIPHPCIVGF 269
Query: 68 RGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRD 127
G ++ +CII ++ G LY+ L Q DIA+GM YLH+ +IIHRD
Sbjct: 270 VGATAKSP-FCIITDYMPNGSLYEDLTFKHRLDATQNTIATYDIARGMQYLHSNEIIHRD 328
Query: 128 LKSPNVLVADNLVAKVSDFGTSREW-DNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWS 186
LKS N+L+ ++L K+ DFG SR E+ GT+ WMAPE++ + S ++DV++
Sbjct: 329 LKSLNILLDEDLKIKICDFGLSRNGAATETVKAQAVGTMQWMAPELLTNGKISSKIDVYA 388
Query: 187 FGVVLWELLTQEIPYKTLETHAILWGVGTETILLPV-PNSCPESLKLLLNQCWDRVPRNR 245
+G++L E+L + P+ + E P+ P+ P+ +K L+ +CW + P+ R
Sbjct: 389 YGIMLAEILICDRPFNQFHDPNEMRKAIIEQQARPILPSRTPKKMKSLMEKCWAQDPQQR 448
Query: 246 PPFKIILAHLDIA-----GAEFSRVLP--DRFSV----TQATWRKEIENEMKEIYTRNKE 294
P F I+ + G + ++ +R A W K IEN Y++ +
Sbjct: 449 PTFSEIIELFETCEYFFDGCDIEKLRSHIERCKANPIYVAADWLKAIEN-----YSKKEM 503
Query: 295 KFEQAQKLQSVRREELRLARDTRLIYEQQLSRANEL 330
FEQ K+ + + ++ I+++ L+ +EL
Sbjct: 504 TFEQFVKMFEKSKMPMSVSESVFKIFKENLNSNSEL 539
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 510
Score = 133 bits (322), Expect = 8e-30
Identities = 88/263 (33%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 8 DWEVPFESITDMMYLGSGAQGVVYSGNLRGEM-VAVKKLREKE--------ETDIMHLRK 58
DWE+P E T LG G VY G +G + VA+K L+ ET I L+K
Sbjct: 235 DWELPKEEFTLEEELGKGFFADVYRGKWKGMVNVAIKILKNDSINHREFMLETQI--LKK 292
Query: 59 LNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHS--GASFTPRQIIRWAKDIAQGMV 116
L H +++ VC+ + II E + G L L G + + A +A GM
Sbjct: 293 LRHKHLIALFAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQMLTEMASQVADGMA 352
Query: 117 YLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTV--AWMAPEVIR 174
YL + IHRDL + NVLV N + KV+D G +R ES S + W APE I
Sbjct: 353 YLEEQNSIHRDLAARNVLVGANYICKVADLGLAR-IVKESVYSSEDAQIPYKWSAPEAIS 411
Query: 175 HEPCSERVDVWSFGVVLWELLTQ-EIPYKTLETHAILWGVGTETILLPVPNSCPESLKLL 233
H S + DVWSFGV+L+E+ T +PY ++ ++ + T +P P +CP + +
Sbjct: 412 HGRFSNKSDVWSFGVLLYEMFTYGGVPYPAF-SNIEVYNMITSGYRMPAPPNCPSHIYDI 470
Query: 234 LNQCWDRVPRNRPPFKIILAHLD 256
+ CW RP F +L L+
Sbjct: 471 MLMCWRYSAEERPDFSELLRLLE 493
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.135 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 533,107,463
Number of Sequences: 1657284
Number of extensions: 22473903
Number of successful extensions: 103905
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 8261
Number of HSP's successfully gapped in prelim test: 3410
Number of HSP's that attempted gapping in prelim test: 76434
Number of HSP's gapped (non-prelim): 15896
length of query: 470
length of database: 575,637,011
effective HSP length: 103
effective length of query: 367
effective length of database: 404,936,759
effective search space: 148611790553
effective search space used: 148611790553
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 74 (33.9 bits)
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