Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002020-TA|BGIBMGA002020-PA|IPR006076|FAD dependent
oxidoreductase, IPR006222|Glycine cleavage T protein (aminomethyl
transferase), IPR013977|Glycine cleavage T-protein, C-terminal barrel
(975 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB082521-1|BAC02699.1| 883|Homo sapiens KIAA1990 protein protein. 478 e-134
AK000941-1|BAA91436.2| 614|Homo sapiens protein ( Homo sapiens ... 272 5e-72
AF047004-1|AAD13136.1| 431|Homo sapiens dimethylglycine dehydro... 233 2e-60
AL590710-3|CAI12276.1| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AL590710-2|CAI12275.1| 609|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AL365494-4|CAI13356.1| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AK223402-1|BAD97122.1| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AJ223317-1|CAA11257.1| 475|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AF162428-1|AAD43585.1| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AF140745-1|AAD32214.1| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AF095735-1|AAD53398.2| 918|Homo sapiens sarcosine dehydrogenase... 231 9e-60
AF047190-1|AAD13137.1| 475|Homo sapiens dimethylglycine dehydro... 231 9e-60
BC033217-1|AAH33217.1| 611|Homo sapiens SARDH protein protein. 204 9e-52
AF095736-1|AAD53399.2| 328|Homo sapiens unknown protein. 202 6e-51
AF111858-1|AAF21941.1| 866|Homo sapiens dimethylglycine dehydro... 187 1e-46
AF129265-1|AAD33412.1| 602|Homo sapiens unknown protein. 180 2e-44
AF095737-1|AAD53400.2| 396|Homo sapiens unknown protein. 180 2e-44
AL590710-4|CAI12277.1| 283|Homo sapiens sarcosine dehydrogenase... 176 4e-43
BC022388-1|AAH22388.1| 613|Homo sapiens DMGDH protein protein. 144 1e-33
AL590710-1|CAI12274.1| 368|Homo sapiens sarcosine dehydrogenase... 134 2e-30
AL365494-3|CAI13355.1| 368|Homo sapiens sarcosine dehydrogenase... 134 2e-30
AF103801-1|AAF02421.1| 486|Homo sapiens unknown protein. 68 1e-10
BC013902-1|AAH13902.1| 486|Homo sapiens FAD-dependent oxidoredu... 68 2e-10
BC006117-1|AAH06117.1| 441|Homo sapiens L2HGDH protein protein. 56 5e-07
AY757363-1|AAV52330.1| 463|Homo sapiens putative L-2-hydroxyglu... 56 5e-07
AK022680-1|BAB14174.1| 463|Homo sapiens protein ( Homo sapiens ... 56 5e-07
D13811-1|BAA02967.1| 403|Homo sapiens glycine cleavage system T... 50 5e-05
BC007546-1|AAH07546.2| 383|Homo sapiens AMT protein protein. 50 5e-05
D14686-1|BAA03512.1| 403|Homo sapiens glycine cleavage system T... 48 2e-04
BC002910-1|AAH02910.2| 367|Homo sapiens FOXRED1 protein protein. 48 2e-04
BC044792-1|AAH44792.1| 270|Homo sapiens AMT protein protein. 35 1.6
U26446-1|AAA67690.1| 477|Homo sapiens protoporphyrinogen oxidas... 33 4.9
D38537-1|BAA07538.1| 477|Homo sapiens protoporphyrinogen oxidas... 33 4.9
BC002357-1|AAH02357.1| 477|Homo sapiens protoporphyrinogen oxid... 33 4.9
AY032687-1|AAK50376.1| 205|Homo sapiens protoporphyrinogen oxid... 33 4.9
AL590714-4|CAH72144.1| 477|Homo sapiens protoporphyrinogen oxid... 33 4.9
>AB082521-1|BAC02699.1| 883|Homo sapiens KIAA1990 protein protein.
Length = 883
Score = 478 bits (1179), Expect = e-134
Identities = 226/484 (46%), Positives = 314/484 (64%), Gaps = 6/484 (1%)
Query: 458 YHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFLGLHNNKRFLRDRVKEV 517
Y V AGM + G+S GG + + ++ GY ++ EL + F L +++ FLR RV EV
Sbjct: 382 YFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSRTFLRHRVMEV 441
Query: 518 PGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFETVENESEKPRP 577
+ Y L P ++F+TGR LR SP+Y L GA + + G+ERP +F + +
Sbjct: 442 MPLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDKDL----- 496
Query: 578 FKIAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTKIDIQSQGREVVELLQYLCSND 637
+ ++TF KP WFD V+ E C+E V + D SSFTK +I S G + +E+LQYL SND
Sbjct: 497 LALEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEVLQYLFSND 556
Query: 638 VDVPVGSIIHTGMQNERGGYENDCSLARISENHYMMIAPTIQQTRCKVWLKRHLPSNGSV 697
+DVPVG I+HTGM NE GGYENDCS+AR+++ + MI+PT QQ C WLK+H+P + ++
Sbjct: 557 LDVPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 616
Query: 698 TLSDVTSMYTAICVMGPFTRXXXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHT 757
L DVT YTA+ ++GP +FP KE+ VG ANGIR M++THT
Sbjct: 617 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFPSLFCKEMSVGYANGIRVMSMTHT 676
Query: 758 GELGYVLYIPNEFALHVYNRLMTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTP 817
GE G++LYIP E+ALHVYN +M+VG+KYGI + GYYA R+LR+EKFFAFWGQD++ +TTP
Sbjct: 677 GEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTP 736
Query: 818 LECGRTWRVKFDKDIKFIGRDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRD 877
LECGR RVK +K + FIGRDALL+Q+++G+ ++ W W GEPIYR+
Sbjct: 737 LECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMFILDDHDSDLDLWPWWGEPIYRN 796
Query: 878 GNYCGQTTTTSYGFTFKKQVCLGFVEKRDKD-GVTQKVDNDYVLSGHYEIDIAGIRYAAK 936
G Y G+TT+++Y ++ ++ VCLGFV +D G Q V D++ G YEIDIAG R+ AK
Sbjct: 797 GQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGYRFQAK 856
Query: 937 VNLH 940
L+
Sbjct: 857 AKLY 860
Score = 266 bits (652), Expect = 3e-70
Identities = 136/338 (40%), Positives = 204/338 (60%), Gaps = 3/338 (0%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LP++A+VVICGGG+ G +VAYHL+ GW D V++E+ ++ AGS +G++ +
Sbjct: 43 LPTQAQVVICGGGITGTSVAYHLSKMGWKD-IVLLEQGRLAAGSTRFCAGILSTARHLTI 101
Query: 106 QVRLAQSSIRLLKELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDLV 164
+ ++A S +L +LE G TG+ + GS+ LA+T+DR+ +R+ + I +++
Sbjct: 102 EQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEII 161
Query: 165 TPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAVLS 224
+PKK EL +LNV D++G + +P D V + ++L A+ GV + + SV V+
Sbjct: 162 SPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMV 221
Query: 225 KDDKVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTKPIDN-L 283
K +V+GVET G IEC YF+NCAG WA ++G V +PL CEH+YL T+P++ L
Sbjct: 222 KKGQVTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPL 281
Query: 284 DPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPEDWDHFHVLLQ 343
TP I D DG IY+R G IL+GGFE KP++ E + L EDWDHF LL
Sbjct: 282 QSSTPTIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWDHFEPLLS 341
Query: 344 ELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
LL+R+P L + KL N E F+PD + I+GE+P +
Sbjct: 342 SLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAV 379
>AK000941-1|BAA91436.2| 614|Homo sapiens protein ( Homo sapiens
cDNA FLJ10079 fis, clone HEMBA1001896, weakly similar to
DIMETHYLGLYCINE DEHYDROGENASE PRECURSOR (EC 1.5.99.2).
).
Length = 614
Score = 272 bits (666), Expect = 5e-72
Identities = 134/312 (42%), Positives = 190/312 (60%), Gaps = 5/312 (1%)
Query: 458 YHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFLGLHNNKRFLRDRVKEV 517
Y V AGM + G+S GG + + ++ GY ++ EL + F L +++ FLR R EV
Sbjct: 106 YFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSRTFLRHRAIEV 165
Query: 518 PGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFETVENESEKPRP 577
+ Y L P ++F+TGR LR SP+Y L GA + + G+ERP +F + +
Sbjct: 166 MPLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDKDL----- 220
Query: 578 FKIAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTKIDIQSQGREVVELLQYLCSND 637
+ ++TF KP WFD V+ E C+E V + D SSFTK +I S G + +E+LQYL S+D
Sbjct: 221 LALEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEVLQYLFSSD 280
Query: 638 VDVPVGSIIHTGMQNERGGYENDCSLARISENHYMMIAPTIQQTRCKVWLKRHLPSNGSV 697
+DVPVG I+HTGM NE GGYENDCS+AR+++ + MI+PT QQ C WLK+H+P + ++
Sbjct: 281 LDVPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 340
Query: 698 TLSDVTSMYTAICVMGPFTRXXXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHT 757
L DVT YTA+ ++GP +FP KE+ VG A GIR M++THT
Sbjct: 341 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFPSLFCKEMSVGYAKGIRVMSMTHT 400
Query: 758 GELGYVLYIPNE 769
GE G++LYIP E
Sbjct: 401 GEPGFMLYIPIE 412
Score = 105 bits (252), Expect = 8e-22
Identities = 47/108 (43%), Positives = 68/108 (62%), Gaps = 1/108 (0%)
Query: 834 FIGRDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTF 893
FIGRDALL+Q+++G+ ++ W W GEPIYR+G Y G+TT+++Y ++
Sbjct: 416 FIGRDALLQQKQNGVYKRLTMFILDDHDSDLDLWPWWGEPIYRNGQYVGKTTSSAYSYSL 475
Query: 894 KKQVCLGFVEKRDKD-GVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLH 940
++ VCLGFV +D G Q V D++ G YEIDIAG R+ AK L+
Sbjct: 476 ERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGYRFQAKAKLY 523
Score = 85.4 bits (202), Expect = 9e-16
Identities = 44/98 (44%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
Query: 285 PMTP-VIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPEDWDHFHVLLQ 343
P+T I D DG IY+R G IL+GGFE KP++ E + L EDWDHF LL
Sbjct: 6 PVTSKAIVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWDHFEPLLS 65
Query: 344 ELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
LL+R+P L + KL N E F+PD + I+GE+P +
Sbjct: 66 SLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAV 103
>AF047004-1|AAD13136.1| 431|Homo sapiens dimethylglycine
dehydrogenase-like protein isoform 1 protein.
Length = 431
Score = 233 bits (570), Expect = 2e-60
Identities = 128/362 (35%), Positives = 214/362 (59%), Gaps = 14/362 (3%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEIFRIIINLPYSTSDSIV 397
F ++ + RVP L + + G E+F+PD K ++GEAPE+ + ++++ +
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGKVQ 416
Query: 398 SV 399
+V
Sbjct: 417 TV 418
>AL590710-3|CAI12276.1| 918|Homo sapiens sarcosine dehydrogenase
protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 204 bits (499), Expect = 9e-52
Identities = 148/520 (28%), Positives = 237/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AL590710-2|CAI12275.1| 609|Homo sapiens sarcosine dehydrogenase
protein.
Length = 609
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 75.8 bits (178), Expect = 7e-13
Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 19/207 (9%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVG 643
+ G + + +L S DV P G
Sbjct: 579 FYL--VGLDARKAADWLFSADVSRPPG 603
>AL365494-4|CAI13356.1| 918|Homo sapiens sarcosine dehydrogenase
protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 204 bits (499), Expect = 9e-52
Identities = 148/520 (28%), Positives = 237/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AK223402-1|BAD97122.1| 918|Homo sapiens sarcosine dehydrogenase
variant protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 204 bits (499), Expect = 9e-52
Identities = 148/520 (28%), Positives = 237/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AJ223317-1|CAA11257.1| 475|Homo sapiens sarcosine dehydrogenase
protein.
Length = 475
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 32.3 bits (70), Expect = 8.6
Identities = 17/64 (26%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPF-LGLHNNKRFLRD 512
++ + + G +VG+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSVGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKE 516
R E
Sbjct: 459 RSHE 462
>AF162428-1|AAD43585.1| 918|Homo sapiens sarcosine dehydrogenase
protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 202 bits (492), Expect = 6e-51
Identities = 147/520 (28%), Positives = 236/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N GG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHXGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVW----LKRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAXGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AF140745-1|AAD32214.1| 918|Homo sapiens sarcosine dehydrogenase
protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 202 bits (492), Expect = 6e-51
Identities = 147/520 (28%), Positives = 236/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N GG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHXGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVW----LKRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAXGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AF095735-1|AAD53398.2| 918|Homo sapiens sarcosine dehydrogenase
protein.
Length = 918
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 204 bits (499), Expect = 9e-52
Identities = 148/520 (28%), Positives = 237/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 459 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 518
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 519 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 578
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +A
Sbjct: 579 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLA 636
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 637 PAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 696
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 697 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 755
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 756 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 816 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 870
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 871 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 906
>AF047190-1|AAD13137.1| 475|Homo sapiens dimethylglycine
dehydrogenase-like protein isoform 2 protein.
Length = 475
Score = 231 bits (565), Expect = 9e-60
Identities = 127/344 (36%), Positives = 206/344 (59%), Gaps = 14/344 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPE-DWDH 337
I+ + M P +RD D +YLR + + GG+E A P++ EE+ + L + DW+
Sbjct: 300 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEEVSDKFAFGLFDLDWEV 356
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 357 FTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 400
Score = 32.3 bits (70), Expect = 8.6
Identities = 17/64 (26%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPF-LGLHNNKRFLRD 512
++ + + G +VG+ GG + II G + DMH + F L ++ R++R+
Sbjct: 399 ELRGFFLGCGFNSVGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 458
Query: 513 RVKE 516
R E
Sbjct: 459 RSHE 462
>BC033217-1|AAH33217.1| 611|Homo sapiens SARDH protein protein.
Length = 611
Score = 204 bits (499), Expect = 9e-52
Identities = 148/520 (28%), Positives = 237/520 (45%), Gaps = 43/520 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 42 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 101
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 102 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 161
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 162 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 221
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +A
Sbjct: 222 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLA 279
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 280 PAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 339
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 340 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 398
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 399 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 458
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
QR G+RR+ V +G E I+R+G G +GF K + G++
Sbjct: 459 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYI 513
Query: 903 EKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 514 --HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 549
>AF095736-1|AAD53399.2| 328|Homo sapiens unknown protein.
Length = 328
Score = 202 bits (492), Expect = 6e-51
Identities = 108/284 (38%), Positives = 173/284 (60%), Gaps = 13/284 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 19 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 77
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 78 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 137
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 138 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 197
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 198 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 255
Query: 279 PIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEE 322
I+ + M P +RD D +YLR + + GG+E A P++ EE
Sbjct: 256 RIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEE 296
>AF111858-1|AAF21941.1| 866|Homo sapiens dimethylglycine
dehydrogenase precursor protein.
Length = 866
Score = 187 bits (456), Expect = 1e-46
Identities = 117/339 (34%), Positives = 188/339 (55%), Gaps = 15/339 (4%)
Query: 49 KAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLAQVR 108
+A+ VI GGG +G ++AYHLA G D V++EK ++ AGS WH++GL F P + +
Sbjct: 49 RAETVIIGGGCVGVSLAYHLAKAGMKD-VVLLEKSELTAGSTWHAAGLTTYFHPGINLKK 107
Query: 109 LAQSSIRLLKELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDLVTPK 167
+ SI+L ++LE G+ G+ Q GS+ LA T R+ ++ +++ + + L+ P+
Sbjct: 108 IHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPE 167
Query: 168 KCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAVLSKDD 227
K E+FP+LN+ VL GL+ PGDG DP+ L M+L A G + VT++ ++ D
Sbjct: 168 KIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSD 227
Query: 228 KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTKPIDNLDPM- 286
VET G++ + +N AGFWAR+VG++ ++ PL+P +H Y+ T I + +
Sbjct: 228 GTWDVETPQGSMRANRIVNAAGFWAREVGKMI--GLEHPLIPVQHQYVVTSTISEVKALK 285
Query: 287 --TPVIRDPDGYIYLR-ERDGCILAGGFEPIAK-PVYEEEIENA-----SQRCLPEDWDH 337
PV+RD +G YLR ERDG +L G +E K V + + N + D D
Sbjct: 286 RELPVLRDLEGSYYLRQERDG-LLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDR 344
Query: 338 FHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVG 376
++ ++ VP L +A + + NG +SPD +VG
Sbjct: 345 IMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVG 383
Score = 172 bits (419), Expect = 4e-42
Identities = 127/448 (28%), Positives = 213/448 (47%), Gaps = 21/448 (4%)
Query: 457 NYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFLGLHNNKRFLRDRVKE 516
NY VA G GI AGGV + D I+ G +D+ EL N + G ++ + +E
Sbjct: 390 NYWVAIGFG-YGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRY-GKWTTTQYTEAKARE 447
Query: 517 VPGVHYGLPYPFYEFETGR-NLRLSPIYPTLRDNGAVFGQVMGYERPTWFETVENESEKP 575
G + + YP E GR R+S +Y L ++ G G+E+P WF +++
Sbjct: 448 SYGFNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSM-GFHAGWEQPHWFYKPGQDTQY- 505
Query: 576 RPFKIAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTKIDIQSQGREVVELLQYLCS 635
RP +F + WF+ V EY +RVG++D S F K +I+ G++ + LL +L +
Sbjct: 506 RP-------SFRRTNWFEPVGSEYKQVMQRVGVTDLSPFGKFNIK--GQDSIRLLDHLFA 556
Query: 636 NDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMMIAPTIQQTRCKVWLKRHLPSNG 695
N + VG + M +G + +++ S +++I + + W++ G
Sbjct: 557 NVIP-KVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGG 615
Query: 696 -SVTLSDVTSMYTAICVMGPFTRXXXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNL 754
V + ++T + V GP R F F K + V + A+ +
Sbjct: 616 YDVEIKNITDELGVLGVAGPQARKVLQKLTPEDLSDDVFKFLQTKSLKVSNIP-VTAIRI 674
Query: 755 THTGELGYVLYIPNEFALHVYNRLMTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTM 814
++TGELG+ LY E ++ +Y+ +M G++ GI + G YA ALR+EK F WG +++
Sbjct: 675 SYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLEMNCD 734
Query: 815 TTPLECGRTWRVKFDKDIKFIGRDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPI 874
T PLE G + VK +K FIG+ AL + + G++R+ V G E I
Sbjct: 735 TNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATDDVDPE----GNESI 790
Query: 875 YRDGNYCGQTTTTSYGFTFKKQVCLGFV 902
+ +G G TT+ SY ++ +K + +V
Sbjct: 791 WYNGKVVGNTTSGSYSYSIQKSLAFAYV 818
>AF129265-1|AAD33412.1| 602|Homo sapiens unknown protein.
Length = 602
Score = 180 bits (438), Expect = 2e-44
Identities = 132/475 (27%), Positives = 213/475 (44%), Gaps = 39/475 (8%)
Query: 454 QMLNYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFL-GLHNNKRFLRD 512
++ + + G + G+ GG + II G + DMH + F L ++ R++R+
Sbjct: 119 ELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRE 178
Query: 513 RVKEVPGVHYGLPYPFYEFETGRNLRLSPIYPTLRDNGAVFGQVMGYERPTWFE------ 566
R E +Y + +P E GRN+R P++ L G VF + G+ERP WF
Sbjct: 179 RSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAP 238
Query: 567 --------TVENESEKPRPFK--IAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTK 616
+ + + ++ +A TF PP D +++E ACR + D S F K
Sbjct: 239 VLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGK 298
Query: 617 IDIQSQGREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IA 675
+ G + + +L S DV P GS ++T M N GG E+D +++R++ +H +A
Sbjct: 299 FYLV--GLDARKAADWLFSADVSRPPGSTVYTCMLNHHGGTESDLTVSRLAPSHQASPLA 356
Query: 676 PTIQQTRCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXX 722
P + + + +H S+ + L D S I + GP +R
Sbjct: 357 PAFEGDGYYLAVGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQE 416
Query: 723 XXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVG 782
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G
Sbjct: 417 VLDADLSNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAG 475
Query: 783 EKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLK 842
K+G+ + GY A +L +EK + W DL +PLE G + K + F+GR+AL +
Sbjct: 476 AKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 535
Query: 843 QREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGFTFKKQV 897
QR G+RR+ V +G E I+R+G G +GF K +
Sbjct: 536 QRAAGLRRRLVCFTMEDKVP-----MFGLEAIWRNGQVVGHVRRADFGFAIDKTI 585
Score = 75.4 bits (177), Expect = 9e-13
Identities = 43/120 (35%), Positives = 69/120 (57%), Gaps = 4/120 (3%)
Query: 263 VKVPLLPCEHYYLHTKPIDNLDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEE 322
VKVPL+ H Y+ T+ I+ + M P +RD D +YLR + + GG+E A P++ EE
Sbjct: 4 VKVPLVAMHHAYVVTERIEGIQNM-PNVRDHDASVYLRLQGDALSVGGYE--ANPIFWEE 60
Query: 323 IENASQRCLPE-DWDHFHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVGEAPEI 381
+ + L + DW+ F ++ + RVP L + + G E+F+PD K ++GEAPE+
Sbjct: 61 VSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPEL 120
>AF095737-1|AAD53400.2| 396|Homo sapiens unknown protein.
Length = 396
Score = 180 bits (438), Expect = 2e-44
Identities = 94/249 (37%), Positives = 152/249 (61%), Gaps = 10/249 (4%)
Query: 46 LPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEKVGAGSRWHSSGLVGAFKPTLA 105
LPS A VV+ GGG +G YHLA G V++E+E++ +G+ WH++GL+ +P+
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLGMSG-AVLLERERLTSGTTWHTAGLLWQLRPSDV 121
Query: 106 QVRLAQSSIRLL-KELEAR-GRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSIDCDL 163
+V L + R++ +ELE G TGW Q G L +A R R+ Y+R+ S ++ ++ +
Sbjct: 122 EVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHV 181
Query: 164 VTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV- 222
++P + L+P++NV+D+ G L++P DG DP C +L R A+ +G V+E+C VT +
Sbjct: 182 LSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIR 241
Query: 223 LSKDD----KVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTK 278
+ DD +V+GVET +G+I+ +NCAG WA VG++A VKVPL+ H Y+ T+
Sbjct: 242 VWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMA--GVKVPLVAMHHAYVVTE 299
Query: 279 PIDNLDPMT 287
I+ + T
Sbjct: 300 RIEGIQSFT 308
>AL590710-4|CAI12277.1| 283|Homo sapiens sarcosine dehydrogenase
protein.
Length = 283
Score = 176 bits (428), Expect = 4e-43
Identities = 93/252 (36%), Positives = 156/252 (61%), Gaps = 12/252 (4%)
Query: 78 VVVEKEKVGAGSRWHSSGLVGAFKPTLAQVRLAQSSIRLL-KELEAR-GRPTGWKQCGSL 135
V++E+E++ +G+ WH++GL+ +P+ +V L + R++ +ELE G TGW Q G L
Sbjct: 5 VLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSRELEEETGLHTGWIQNGGL 64
Query: 136 LLARTRDRMTVYRRMKSQSVSWSIDCDLVTPKKCHELFPMLNVEDVLGGLWIPGDGVGDP 195
+A R R+ Y+R+ S ++ ++ +++P + L+P++NV+D+ G L++P DG DP
Sbjct: 65 FIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDP 124
Query: 196 HLLCMSLMREATDKGVGVMEDCSVTAV-LSKDD----KVSGVETTNGAIECDYFINCAGF 250
C +L R A+ +G V+E+C VT + + DD +V+GVET +G+I+ +NCAG
Sbjct: 125 AGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGV 184
Query: 251 WARQVGQLARPQVKVPLLPCEHYYLHTKPIDNLDPMTPVIRDPDGYIYLRERDGCILAGG 310
WA VG++A VKVPL+ H Y+ T+ I+ + M P +RD D +YLR + + GG
Sbjct: 185 WASAVGRMA--GVKVPLVAMHHAYVVTERIEGIQNM-PNVRDHDASVYLRLQGDALSVGG 241
Query: 311 FEPIAKPVYEEE 322
+E A P++ EE
Sbjct: 242 YE--ANPIFWEE 251
>BC022388-1|AAH22388.1| 613|Homo sapiens DMGDH protein protein.
Length = 613
Score = 144 bits (349), Expect = 1e-33
Identities = 108/377 (28%), Positives = 180/377 (47%), Gaps = 17/377 (4%)
Query: 457 NYHVAAGMKTVGISAAGGVAEATVDEIIDGYSKYDMHELGVNPFLGLHNNKRFLRDRVKE 516
NY VA G GI AGGV + D I+ G +D+ EL N + G ++ + +E
Sbjct: 229 NYWVAIGFG-YGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRY-GKWTTTQYTEAKARE 286
Query: 517 VPGVHYGLPYPFYEFETGR-NLRLSPIYPTLRDNGAVFGQVMGYERPTWFETVENESEKP 575
G + + YP E GR R+S +Y L ++ G G+E+P WF +++
Sbjct: 287 SYGFNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSM-GFHAGWEQPHWFYKPGQDTQY- 344
Query: 576 RPFKIAHTRTFGKPPWFDAVQREYWACRERVGLSDYSSFTKIDIQSQGREVVELLQYLCS 635
RP +F + WF+ V EY +RV ++D S F K +I+ G++ + LL +L +
Sbjct: 345 RP-------SFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIK--GQDSIRLLDHLFA 395
Query: 636 NDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMMIAPTIQQTRCKVWLKRHLPSNG 695
N + VG + M +G + +++ S +++I + + W++ G
Sbjct: 396 NVIP-KVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEEAVKGG 454
Query: 696 -SVTLSDVTSMYTAICVMGPFTRXXXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNL 754
V + ++T + V GP R F F K + V + A+ +
Sbjct: 455 YDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIP-VTAIRI 513
Query: 755 THTGELGYVLYIPNEFALHVYNRLMTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTM 814
++TGELG+ LY E ++ +Y+ +M G++ GI + G YA ALR+EK F WG +++
Sbjct: 514 SYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLEMNCD 573
Query: 815 TTPLECGRTWRVKFDKD 831
T PLE G + VK +KD
Sbjct: 574 TNPLEAGLEYFVKLNKD 590
Score = 121 bits (291), Expect = 1e-26
Identities = 77/224 (34%), Positives = 120/224 (53%), Gaps = 13/224 (5%)
Query: 163 LVTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCSVTAV 222
L+ P+K E+FP+LN+ VL GL+ PGDG DP+ L M+L A G + VT++
Sbjct: 2 LIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSL 61
Query: 223 LSKDDKVSGVETTNGAIECDYFINCAGFWARQVGQLARPQVKVPLLPCEHYYLHTKPIDN 282
++ D VET G++ + +N AGFWAR+VG++ ++ PL+P +H Y+ T I
Sbjct: 62 KARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMI--GLEHPLIPVQHQYVVTSTISE 119
Query: 283 LDPM---TPVIRDPDGYIYLR-ERDGCILAGGFEPIAK-PVYEEEIENA-----SQRCLP 332
+ + PV+RD +G YLR ERDG +L G +E K V + + N +
Sbjct: 120 VKALKRELPVLRDLEGSYYLRQERDG-LLFGPYESQEKMKVQDSWVTNGVPPGFGKELFE 178
Query: 333 EDWDHFHVLLQELLQRVPGLNQAVLHKLCNGLEAFSPDCKWIVG 376
D D ++ ++ VP L +A + + NG +SPD +VG
Sbjct: 179 SDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVG 222
>AL590710-1|CAI12274.1| 368|Homo sapiens sarcosine dehydrogenase
protein.
Length = 368
Score = 134 bits (323), Expect = 2e-30
Identities = 100/351 (28%), Positives = 156/351 (44%), Gaps = 36/351 (10%)
Query: 623 GREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IAPTIQQT 681
G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +AP +
Sbjct: 11 GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGD 70
Query: 682 RCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXXXXXXXX 728
+ + +H S+ + L D S I + GP +R
Sbjct: 71 GYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADL 130
Query: 729 XXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVGEKYGIS 788
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G K+G+
Sbjct: 131 SNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLI 189
Query: 789 HVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLKQREDGI 848
+ GY A +L +EK + W DL +PLE G + K + F+GR+AL +QR G+
Sbjct: 190 NAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGL 249
Query: 849 RRQYV-----------------QXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGF 891
RR+ V +G E I+R+G G +GF
Sbjct: 250 RRRLVCFTMEEPLWTRPHPAVSGAPAFSTASSSKVPMFGLEAIWRNGQVVGHVRRADFGF 309
Query: 892 TFKKQVCLGFVEKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
K + G++ D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 310 AIDKTIAYGYI--HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 356
>AL365494-3|CAI13355.1| 368|Homo sapiens sarcosine dehydrogenase
protein.
Length = 368
Score = 134 bits (323), Expect = 2e-30
Identities = 100/351 (28%), Positives = 156/351 (44%), Gaps = 36/351 (10%)
Query: 623 GREVVELLQYLCSNDVDVPVGSIIHTGMQNERGGYENDCSLARISENHYMM-IAPTIQQT 681
G + + +L S DV P GS ++T M N RGG E+D +++R++ +H +AP +
Sbjct: 11 GLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGD 70
Query: 682 RCKVWL----KRHLPSNGSVTLSDVTSMYTAI---------CVMGPFTRXXXXXXXXXXX 728
+ + +H S+ + L D S I + GP +R
Sbjct: 71 GYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADL 130
Query: 729 XXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRLMTVGEKYGIS 788
FPF T K + + +RAM L+ GELG+ L+IP + VY +M G K+G+
Sbjct: 131 SNEAFPFSTHKLLRAA-GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLI 189
Query: 789 HVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRVKFDKDIKFIGRDALLKQREDGI 848
+ GY A +L +EK + W DL +PLE G + K + F+GR+AL +QR G+
Sbjct: 190 NAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGL 249
Query: 849 RRQYV-----------------QXXXXXXXXXXXXWSWGGEPIYRDGNYCGQTTTTSYGF 891
RR+ V +G E I+R+G G +GF
Sbjct: 250 RRRLVCFTMEEPLWTRPHPAVSGAPAFSTASSSKVPMFGLEAIWRNGQVVGHVRRADFGF 309
Query: 892 TFKKQVCLGFVEKRDKDGVTQKVDNDYVLSGHYEIDIAGIRYAAKVNLHSP 942
K + G++ D G V D+V SG Y ++ G+ Y A+ +L SP
Sbjct: 310 AIDKTIAYGYI--HDPSG--GPVSLDFVKSGDYALERMGVTYGAQAHLKSP 356
>AF103801-1|AAF02421.1| 486|Homo sapiens unknown protein.
Length = 486
Score = 68.1 bits (159), Expect = 1e-10
Identities = 105/400 (26%), Positives = 164/400 (41%), Gaps = 57/400 (14%)
Query: 39 LEDCLSVLPSKAKVVICGGGVMGAAVAY---HLANRGWGDRTVVVEKEKV--GAGSRWHS 93
L+D + P + VVI GGGV+G +VAY L +R R +VVE++ A +
Sbjct: 53 LQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSV 112
Query: 94 SGLVGAFK-PTLAQVRLAQSS-IRLLKE----LEARGRPTGWKQCGSLLLARTRDRMTVY 147
G+ F P Q+ L +S +R + E ++A + G LLLA +D +
Sbjct: 113 GGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAME 172
Query: 148 RRMKSQSVSWSIDCDLVTPKKCHELFPMLNVEDV-LGGLWIPGDGVGDPHLLCMSLMREA 206
+K Q L++P + FP +N E V L + +G DP L L R+
Sbjct: 173 SNVKVQRQE-GAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKV 231
Query: 207 TDKGVGVMED------CSVTAVLSKDDKVSGVETTNGA------------IECDYFINCA 248
GV + S +L+ DDK ++ + +EC IN A
Sbjct: 232 QSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAA 291
Query: 249 GFWARQVGQLA---------RPQVKVPLLPCEHY-YL-HTKPIDNLDPMTPVIRDPDGYI 297
G W+ Q+ LA K+P+ P + Y Y+ H L+ TP++ D G
Sbjct: 292 GAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLE--TPLVADTSGAY 349
Query: 298 YLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPEDWDHFH-VLLQELLQRVPGLNQAV 356
+ RE G GG P +EE + A+ L D D F + L RVP
Sbjct: 350 FRREGLGSNYLGG----RSPTEQEEPDPAN---LEVDHDFFQDKVWPHLALRVPAFETLK 402
Query: 357 LHKLCNGLEAFSP-DCKWIVGEAPEIFRIIINLPYSTSDS 395
+ G ++ D +VG P +++N+ ++T S
Sbjct: 403 VQSAWAGYYDYNTFDQNGVVGPHP----LVVNMYFATGFS 438
>BC013902-1|AAH13902.1| 486|Homo sapiens FAD-dependent
oxidoreductase domain containing 1 protein.
Length = 486
Score = 67.7 bits (158), Expect = 2e-10
Identities = 105/400 (26%), Positives = 164/400 (41%), Gaps = 57/400 (14%)
Query: 39 LEDCLSVLPSKAKVVICGGGVMGAAVAY---HLANRGWGDRTVVVEKEKV--GAGSRWHS 93
L+D + P + VVI GGGV+G +VAY L +R R +VVE++ A +
Sbjct: 53 LQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSV 112
Query: 94 SGLVGAFK-PTLAQVRLAQSS-IRLLKE----LEARGRPTGWKQCGSLLLARTRDRMTVY 147
G+ F P Q+ L +S +R + E ++A + G LLLA +D +
Sbjct: 113 GGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAME 172
Query: 148 RRMKSQSVSWSIDCDLVTPKKCHELFPMLNVEDV-LGGLWIPGDGVGDPHLLCMSLMREA 206
+K Q L++P + FP +N E V L + +G DP L L R+
Sbjct: 173 SNVKVQRQE-GAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKV 231
Query: 207 TDKGVGVMED------CSVTAVLSKDDKVSGVETTNGA------------IECDYFINCA 248
GV + S +L+ DDK ++ + +EC IN A
Sbjct: 232 QSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAA 291
Query: 249 GFWARQVGQLA---------RPQVKVPLLPCEHY-YL-HTKPIDNLDPMTPVIRDPDGYI 297
G W+ Q+ LA K+P+ P + Y Y+ H L+ TP++ D G
Sbjct: 292 GAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLE--TPLVPDTSGAY 349
Query: 298 YLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPEDWDHFH-VLLQELLQRVPGLNQAV 356
+ RE G GG P +EE + A+ L D D F + L RVP
Sbjct: 350 FRREGLGSNYLGG----RSPTEQEEPDPAN---LEVDHDFFQDKVWPHLALRVPAFETLK 402
Query: 357 LHKLCNGLEAFSP-DCKWIVGEAPEIFRIIINLPYSTSDS 395
+ G ++ D +VG P +++N+ ++T S
Sbjct: 403 VQSAWAGYYDYNTFDQNGVVGPHP----LVVNMYFATGFS 438
>BC006117-1|AAH06117.1| 441|Homo sapiens L2HGDH protein protein.
Length = 441
Score = 56.4 bits (130), Expect = 5e-07
Identities = 58/252 (23%), Positives = 111/252 (44%), Gaps = 20/252 (7%)
Query: 44 SVLPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEK-VGAGSRWHSSGLVGA--- 99
S S +VI GGG++G A A L R V+EKEK + H+SG++ +
Sbjct: 43 SASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIY 102
Query: 100 FKPTLAQVRLAQSSIRLLKELEARGRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSI 159
+KP + +L LL E + + +KQCG L++A ++ + + + + + +
Sbjct: 103 YKPESLKAKLCVQGAALLYEY-CQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGV 161
Query: 160 D-CDLVTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCS 218
L+ + + P L + P G+ D + +S ++ + G V+ +
Sbjct: 162 PGLRLIQQEDIKKKEPYCRG---LMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFE 218
Query: 219 VTAV-LSKDD---KVSG------VETTNGA-IECDYFINCAGFWARQVGQLARPQVKVPL 267
V + ++K+ + G ++ T G I C Y + CAG ++ ++ +L+ +
Sbjct: 219 VKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRI 278
Query: 268 LPCEHYYLHTKP 279
+P YL KP
Sbjct: 279 VPFRGDYLLLKP 290
>AY757363-1|AAV52330.1| 463|Homo sapiens putative
L-2-hydroxyglutarate dehydrogenase protein.
Length = 463
Score = 56.4 bits (130), Expect = 5e-07
Identities = 58/252 (23%), Positives = 111/252 (44%), Gaps = 20/252 (7%)
Query: 44 SVLPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEK-VGAGSRWHSSGLVGA--- 99
S S +VI GGG++G A A L R V+EKEK + H+SG++ +
Sbjct: 43 SASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIY 102
Query: 100 FKPTLAQVRLAQSSIRLLKELEARGRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSI 159
+KP + +L LL E + + +KQCG L++A ++ + + + + + +
Sbjct: 103 YKPESLKAKLCVQGAALLYEY-CQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGV 161
Query: 160 D-CDLVTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCS 218
L+ + + P L + P G+ D + +S ++ + G V+ +
Sbjct: 162 PGLRLIQQEDIKKKEPYCRG---LMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFE 218
Query: 219 VTAV-LSKDD---KVSG------VETTNGA-IECDYFINCAGFWARQVGQLARPQVKVPL 267
V + ++K+ + G ++ T G I C Y + CAG ++ ++ +L+ +
Sbjct: 219 VKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRI 278
Query: 268 LPCEHYYLHTKP 279
+P YL KP
Sbjct: 279 VPFRGDYLLLKP 290
>AK022680-1|BAB14174.1| 463|Homo sapiens protein ( Homo sapiens
cDNA FLJ12618 fis, clone NT2RM4001666, weakly similar to
HYPOTHETICAL 48.6 KD PROTEIN IN ALPA-GABP INTERGENIC
REGION. ).
Length = 463
Score = 56.4 bits (130), Expect = 5e-07
Identities = 58/252 (23%), Positives = 111/252 (44%), Gaps = 20/252 (7%)
Query: 44 SVLPSKAKVVICGGGVMGAAVAYHLANRGWGDRTVVVEKEK-VGAGSRWHSSGLVGA--- 99
S S +VI GGG++G A A L R V+EKEK + H+SG++ +
Sbjct: 43 SASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIY 102
Query: 100 FKPTLAQVRLAQSSIRLLKELEARGRPTGWKQCGSLLLARTRDRMTVYRRMKSQSVSWSI 159
+KP + +L LL E + + +KQCG L++A ++ + + + + + +
Sbjct: 103 YKPESLKAKLCVQGAALLYEY-CQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGV 161
Query: 160 D-CDLVTPKKCHELFPMLNVEDVLGGLWIPGDGVGDPHLLCMSLMREATDKGVGVMEDCS 218
L+ + + P L + P G+ D + +S ++ + G V+ +
Sbjct: 162 PGLRLIQQEDIKKKEPYCRG---LMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFE 218
Query: 219 VTAV-LSKDD---KVSG------VETTNGA-IECDYFINCAGFWARQVGQLARPQVKVPL 267
V + ++K+ + G ++ T G I C Y + CAG ++ ++ +L+ +
Sbjct: 219 VKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRI 278
Query: 268 LPCEHYYLHTKP 279
+P YL KP
Sbjct: 279 VPFRGDYLLLKP 290
>D13811-1|BAA02967.1| 403|Homo sapiens glycine cleavage system
T-protein protein.
Length = 403
Score = 49.6 bits (113), Expect = 5e-05
Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 21/307 (6%)
Query: 603 RERVGLSDYSSFTKIDIQSQGREVVELLQYLCSNDV-DVPVGSIIHTGMQNERGGYENDC 661
R+ L D S + I R V+L++ L D+ ++ + NE GG +D
Sbjct: 73 RQHCSLFDVSHMLQTKILGSDR--VKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDL 130
Query: 662 SLARISENHYMMIAPTIQQTRCKVWLK---RHLPSNGSVTLSDVTSMYTAICVMGPFTRX 718
+ SE H +++ + ++ R L + G +V + + GP
Sbjct: 131 IVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDN-ALLALQGP--TA 187
Query: 719 XXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRL 778
PF T ++V +G R +TGE G + +P A+H+ +
Sbjct: 188 AQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAI 247
Query: 779 MTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRV--KFDKDIKFIG 836
+ E + G A +LR+E +G D+D TTP+E +W + + + F G
Sbjct: 248 LKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPG 304
Query: 837 RDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYR-DGNYCGQTTTTSYGFTFKK 895
++ Q + ++R+ V PI +G G T+ + KK
Sbjct: 305 AKVIVPQLKGRVQRRRVGLMCEGAPMRAH------SPILNMEGTKIGTVTSGCPSPSLKK 358
Query: 896 QVCLGFV 902
V +G+V
Sbjct: 359 NVAMGYV 365
>BC007546-1|AAH07546.2| 383|Homo sapiens AMT protein protein.
Length = 383
Score = 49.6 bits (113), Expect = 5e-05
Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 21/307 (6%)
Query: 603 RERVGLSDYSSFTKIDIQSQGREVVELLQYLCSNDV-DVPVGSIIHTGMQNERGGYENDC 661
R+ L D S + I R V+L++ L D+ ++ + NE GG +D
Sbjct: 70 RQHCSLFDVSHMLQTKILGSDR--VKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDL 127
Query: 662 SLARISENHYMMIAPTIQQTRCKVWLK---RHLPSNGSVTLSDVTSMYTAICVMGPFTRX 718
+ SE H +++ + ++ R L + G +V + + GP
Sbjct: 128 IVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDN-ALLALQGP--TA 184
Query: 719 XXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPNEFALHVYNRL 778
PF T ++V +G R +TGE G + +P A+H+ +
Sbjct: 185 AQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAI 244
Query: 779 MTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRV--KFDKDIKFIG 836
+ E + G A +LR+E +G D+D TTP+E +W + + + F G
Sbjct: 245 LKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPG 301
Query: 837 RDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYR-DGNYCGQTTTTSYGFTFKK 895
++ Q + ++R+ V PI +G G T+ + KK
Sbjct: 302 AKVIVPQLKGRVQRRRVGLMCEGAPMRAH------SPILNMEGTKIGTVTSGCPSPSLKK 355
Query: 896 QVCLGFV 902
V +G+V
Sbjct: 356 NVAMGYV 362
>D14686-1|BAA03512.1| 403|Homo sapiens glycine cleavage system
T-protein protein.
Length = 403
Score = 48.0 bits (109), Expect = 2e-04
Identities = 56/257 (21%), Positives = 99/257 (38%), Gaps = 18/257 (7%)
Query: 652 NERGGYENDCSLARISENHYMMIAPTIQQTRCKVWLK---RHLPSNGSVTLSDVTSMYTA 708
NE GG +D + SE H +++ + ++ R L + G +V
Sbjct: 121 NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDN-AL 179
Query: 709 ICVMGPFTRXXXXXXXXXXXXXXNFPFFTFKEIDVGLANGIRAMNLTHTGELGYVLYIPN 768
+ + GP PF T ++V +G R +TGE G + +P
Sbjct: 180 LALQGP--TAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPV 237
Query: 769 EFALHVYNRLMTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWRV-- 826
A+H+ ++ E + G A +LR+E +G D+D TTP+E +W +
Sbjct: 238 AGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGK 294
Query: 827 KFDKDIKFIGRDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYR-DGNYCGQTT 885
+ + F G ++ Q + ++R+ V PI +G G T
Sbjct: 295 RRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAH------SPILNMEGTKIGTVT 348
Query: 886 TTSYGFTFKKQVCLGFV 902
+ + KK V +G+V
Sbjct: 349 SGCPSPSLKKNVAMGYV 365
>BC002910-1|AAH02910.2| 367|Homo sapiens FOXRED1 protein protein.
Length = 367
Score = 47.6 bits (108), Expect = 2e-04
Identities = 75/295 (25%), Positives = 117/295 (39%), Gaps = 46/295 (15%)
Query: 133 GSLLLARTRDRMTVYRRMKSQSVSWSIDCDLVTPKKCHELFPMLNVEDV-LGGLWIPGDG 191
G LLLA +D + +K Q + L++P + FP +N E V L + +G
Sbjct: 39 GYLLLASEKDAAAMESNVKVQRQEGA-KVSLMSPDQLRNKFPWINTEGVALASYGMEDEG 97
Query: 192 VGDPHLLCMSLMREATDKGVGVMED------CSVTAVLSKDDKVSGVETTNGA------- 238
DP L L R+ GV + S +L+ DDK ++ +
Sbjct: 98 WFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRS 157
Query: 239 -----IECDYFINCAGFWARQVGQLA---------RPQVKVPLLPCEHY-YL-HTKPIDN 282
+EC IN AG W+ Q+ LA K+P+ P + Y Y+ H
Sbjct: 158 LEYQPVECAIVINAAGAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPG 217
Query: 283 LDPMTPVIRDPDGYIYLRERDGCILAGGFEPIAKPVYEEEIENASQRCLPEDWDHFH-VL 341
L+ TP++ D G + RE G GG P +EE + A+ L D D F +
Sbjct: 218 LE--TPLVADTSGAYFRREGLGSNYLGG----RSPTEQEEPDPAN---LEVDHDFFQDKV 268
Query: 342 LQELLQRVPGLNQAVLHKLCNGLEAFSP-DCKWIVGEAPEIFRIIINLPYSTSDS 395
L RVP + G ++ D +VG P +++N+ ++T S
Sbjct: 269 WPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHP----LVVNMYFATGFS 319
>BC044792-1|AAH44792.1| 270|Homo sapiens AMT protein protein.
Length = 270
Score = 34.7 bits (76), Expect = 1.6
Identities = 33/140 (23%), Positives = 58/140 (41%), Gaps = 12/140 (8%)
Query: 766 IPNEFALHVYNRLMTVGEKYGISHVGYYASRALRVEKFFAFWGQDLDTMTTPLECGRTWR 825
+P A+H+ ++ E + G A LR+E +G D+D TTP+E G +W
Sbjct: 102 VPVAGAVHLATAILKNPE---VKLAGLAARDTLRLEAGLCLYGNDIDEHTTPVEGGLSWT 158
Query: 826 V--KFDKDIKFIGRDALLKQREDGIRRQYVQXXXXXXXXXXXXWSWGGEPIYR-DGNYCG 882
+ + + F G ++ Q + ++R+ V PI +G G
Sbjct: 159 LGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAH------SPILNMEGTKIG 212
Query: 883 QTTTTSYGFTFKKQVCLGFV 902
T+ + KK V +G+V
Sbjct: 213 TVTSGCPSPSLKKNVAMGYV 232
>U26446-1|AAA67690.1| 477|Homo sapiens protoporphyrinogen oxidase
protein.
Length = 477
Score = 33.1 bits (72), Expect = 4.9
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 52 VVICGGGVMGAAVAYHLANRGWGDRTVVVE-KEKVGAGSR 90
VV+ GGG+ G A +YHL+ + V+VE E++G R
Sbjct: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR 44
>D38537-1|BAA07538.1| 477|Homo sapiens protoporphyrinogen oxidase
protein.
Length = 477
Score = 33.1 bits (72), Expect = 4.9
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 52 VVICGGGVMGAAVAYHLANRGWGDRTVVVE-KEKVGAGSR 90
VV+ GGG+ G A +YHL+ + V+VE E++G R
Sbjct: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR 44
>BC002357-1|AAH02357.1| 477|Homo sapiens protoporphyrinogen
oxidase protein.
Length = 477
Score = 33.1 bits (72), Expect = 4.9
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 52 VVICGGGVMGAAVAYHLANRGWGDRTVVVE-KEKVGAGSR 90
VV+ GGG+ G A +YHL+ + V+VE E++G R
Sbjct: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR 44
>AY032687-1|AAK50376.1| 205|Homo sapiens protoporphyrinogen
oxidase protein.
Length = 205
Score = 33.1 bits (72), Expect = 4.9
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 52 VVICGGGVMGAAVAYHLANRGWGDRTVVVE-KEKVGAGSR 90
VV+ GGG+ G A +YHL+ + V+VE E++G R
Sbjct: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR 44
>AL590714-4|CAH72144.1| 477|Homo sapiens protoporphyrinogen
oxidase protein.
Length = 477
Score = 33.1 bits (72), Expect = 4.9
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 52 VVICGGGVMGAAVAYHLANRGWGDRTVVVE-KEKVGAGSR 90
VV+ GGG+ G A +YHL+ + V+VE E++G R
Sbjct: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR 44
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.139 0.435
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 149,647,399
Number of Sequences: 224733
Number of extensions: 6628567
Number of successful extensions: 10525
Number of sequences better than 10.0: 36
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 10305
Number of HSP's gapped (non-prelim): 91
length of query: 975
length of database: 73,234,838
effective HSP length: 97
effective length of query: 878
effective length of database: 51,435,737
effective search space: 45160577086
effective search space used: 45160577086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 70 (32.3 bits)
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