Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001988-TA|BGIBMGA001988-PA|IPR002110|Ankyrin,
IPR005821|Ion transport
(1384 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL442645-3|CAM17593.1| 1569|Homo sapiens transient receptor pote... 628 e-179
AL358786-3|CAM15779.1| 1569|Homo sapiens transient receptor pote... 628 e-179
AL356318-9|CAM13167.1| 1569|Homo sapiens transient receptor pote... 628 e-179
AL159990-7|CAM13093.1| 1569|Homo sapiens transient receptor pote... 628 e-179
AF536751-1|AAO49156.1| 1544|Homo sapiens calcium-permeable store... 628 e-179
AB099663-1|BAC55104.1| 1544|Homo sapiens hypothetical protein pr... 628 e-179
AB099662-1|BAC55103.1| 1569|Homo sapiens hypothetical protein pr... 628 e-179
AL442645-6|CAM17596.1| 1704|Homo sapiens transient receptor pote... 622 e-177
AL442645-5|CAM17595.1| 1322|Homo sapiens transient receptor pote... 622 e-177
AL358786-6|CAM15782.1| 1704|Homo sapiens transient receptor pote... 622 e-177
AL358786-5|CAM15781.1| 1322|Homo sapiens transient receptor pote... 622 e-177
AL356318-12|CAM13169.1| 1704|Homo sapiens transient receptor pot... 622 e-177
AL356318-11|CAM13168.1| 1322|Homo sapiens transient receptor pot... 622 e-177
AL161913-2|CAM22746.1| 1704|Homo sapiens transient receptor pote... 622 e-177
AL161913-1|CAM22745.1| 1322|Homo sapiens transient receptor pote... 622 e-177
AL159990-10|CAM13096.1| 1704|Homo sapiens transient receptor pot... 622 e-177
AL159990-9|CAM13095.1| 1322|Homo sapiens transient receptor pote... 622 e-177
AL442645-2|CAM17592.1| 1579|Homo sapiens transient receptor pote... 621 e-177
AL358786-2|CAM15778.1| 1579|Homo sapiens transient receptor pote... 621 e-177
AL356318-2|CAM13164.1| 1579|Homo sapiens transient receptor pote... 621 e-177
AL159990-2|CAM13091.1| 1579|Homo sapiens transient receptor pote... 621 e-177
AJ505026-1|CAD43605.1| 1325|Homo sapiens long transient receptor... 621 e-177
AJ505025-1|CAD43604.1| 1707|Homo sapiens long transient receptor... 621 e-177
AF536753-1|AAO49158.1| 1579|Homo sapiens calcium-permeable store... 621 e-177
AF536748-1|AAO49153.1| 1554|Homo sapiens calcium-permeable store... 621 e-177
AB099664-1|BAC55105.1| 1579|Homo sapiens hypothetical protein pr... 621 e-177
AB099661-1|BAC55102.1| 1554|Homo sapiens hypothetical protein pr... 621 e-177
AL442645-1|CAM17591.1| 1552|Homo sapiens transient receptor pote... 619 e-176
AL358786-1|CAM15777.1| 1552|Homo sapiens transient receptor pote... 619 e-176
AL356318-1|CAM13163.1| 1552|Homo sapiens transient receptor pote... 619 e-176
AL159990-1|CAM13090.1| 1552|Homo sapiens transient receptor pote... 619 e-176
AL442645-7|CAM17597.1| 1711|Homo sapiens transient receptor pote... 619 e-176
AL391819-1|CAM23807.1| 1711|Homo sapiens transient receptor pote... 619 e-176
AL358786-7|CAM15783.1| 1711|Homo sapiens transient receptor pote... 619 e-176
AL356318-13|CAM13170.1| 1711|Homo sapiens transient receptor pot... 619 e-176
AL159990-11|CAM13097.1| 1711|Homo sapiens transient receptor pot... 619 e-176
AF536752-1|AAO49157.1| 1556|Homo sapiens calcium-permeable store... 619 e-176
AF536749-1|AAO49154.1| 1566|Homo sapiens calcium-permeable store... 612 e-174
AL442645-4|CAM17594.1| 1566|Homo sapiens transient receptor pote... 606 e-172
AL358786-4|CAM15780.1| 1566|Homo sapiens transient receptor pote... 606 e-172
AL356318-8|CAM13166.1| 1566|Homo sapiens transient receptor pote... 606 e-172
AL159990-8|CAM13094.1| 1566|Homo sapiens transient receptor pote... 606 e-172
AF536750-1|AAO49155.1| 1566|Homo sapiens calcium-permeable store... 606 e-172
AB099665-1|BAC55106.1| 1526|Homo sapiens hypothetical protein pr... 576 e-163
AF071787-1|AAC80000.1| 1533|Homo sapiens melastatin 1 protein. 507 e-142
AB115502-1|BAC80204.1| 1527|Homo sapiens melastatin 1 splicing v... 507 e-142
AB115501-1|BAC80203.1| 1533|Homo sapiens melastatin 1 protein. 507 e-142
AB115499-1|BAC80201.1| 1533|Homo sapiens melastatin 1 protein. 507 e-142
AB115498-1|BAC80200.1| 1533|Homo sapiens melastatin 1 protein. 507 e-142
AY333285-1|AAR03490.1| 1943|Homo sapiens truncated transient rec... 506 e-142
AY333284-1|AAR03489.1| 2017|Homo sapiens transient receptor pote... 506 e-142
AY333283-1|AAR03488.1| 2017|Homo sapiens transient receptor pote... 506 e-142
AY333282-1|AAR03487.1| 2022|Homo sapiens transient receptor pote... 506 e-142
AL354795-2|CAH70894.1| 2022|Homo sapiens transient receptor pote... 506 e-142
AL354795-1|CAH70893.1| 1133|Homo sapiens transient receptor pote... 506 e-142
AK026281-1|BAB15429.1| 1133|Homo sapiens protein ( Homo sapiens ... 506 e-142
AF448232-1|AAM21562.1| 2022|Homo sapiens LTRPC6 channel kinase 2... 506 e-142
AF350881-1|AAK31202.2| 2022|Homo sapiens channel-kinase 2 protein. 506 e-142
AB046836-1|BAB13442.1| 1017|Homo sapiens KIAA1616 protein protein. 384 e-105
AY032950-1|AAK44211.1| 1865|Homo sapiens LTRPC7 protein. 359 5e-98
AF346629-1|AAK19738.2| 1864|Homo sapiens channel-kinase 1 protein. 359 5e-98
BC051024-1|AAH51024.1| 535|Homo sapiens TRPM7 protein protein. 295 9e-79
BC093789-1|AAH93789.1| 1165|Homo sapiens transient receptor pote... 245 1e-63
BC093787-1|AAH93787.1| 1165|Homo sapiens transient receptor pote... 245 1e-63
AJ270996-1|CAB66342.1| 1159|Homo sapiens LTRPC5 protein protein. 245 1e-63
AF177473-1|AAF26288.1| 1165|Homo sapiens MTR1 protein. 245 1e-63
BC132727-1|AAI32728.1| 1214|Homo sapiens transient receptor pote... 228 1e-58
AY297045-1|AAP44474.1| 1214|Homo sapiens transient receptor pote... 228 1e-58
AY297044-1|AAP44473.1| 1040|Homo sapiens transient receptor pote... 228 1e-58
AY046396-1|AAL02142.1| 1040|Homo sapiens TRP-related cation infl... 228 1e-58
AK000048-1|BAA90907.1| 1016|Homo sapiens protein ( Homo sapiens ... 228 1e-58
AJ575813-1|CAE05941.1| 1214|Homo sapiens transient receptor pote... 228 1e-58
AF497623-1|AAM18083.1| 1214|Homo sapiens cation channel TRPM4B p... 228 1e-58
AK000124-1|BAA90958.1| 575|Homo sapiens protein ( Homo sapiens ... 190 2e-47
AY333286-1|AAR03491.1| 973|Homo sapiens M6-kinase 1 protein. 184 3e-45
AY333287-1|AAR03492.1| 855|Homo sapiens M6-kinase 2 protein. 147 2e-34
DQ012935-1|AAY22174.1| 1503|Homo sapiens transient receptor pote... 147 3e-34
BC112342-1|AAI12343.1| 1553|Homo sapiens TRPM2 protein protein. 147 3e-34
AY603182-1|AAT12288.1| 846|Homo sapiens TRPM2-S protein. 147 3e-34
AP001754-4|BAA95563.1| 1503|Homo sapiens transient receptor pote... 147 3e-34
AJ878416-1|CAI47593.1| 1503|Homo sapiens transient receptor pote... 147 3e-34
AB166746-1|BAD83706.1| 1289|Homo sapiens transient receptor pote... 147 3e-34
AB166745-1|BAD83705.1| 1503|Homo sapiens transient receptor pote... 147 3e-34
AB001535-1|BAA34700.1| 1503|Homo sapiens KNP3 protein. 147 3e-34
AJ417076-1|CAD01139.1| 1449|Homo sapiens putative TRP cation cha... 143 5e-33
AY297046-1|AAP44475.1| 1069|Homo sapiens transient receptor pote... 134 2e-30
DQ139309-1|AAZ73614.1| 1104|Homo sapiens transient receptor pote... 113 6e-24
AY328400-1|AAP92167.1| 1104|Homo sapiens transient receptor pote... 113 6e-24
AY090109-1|AAM10446.1| 1104|Homo sapiens transient receptor pote... 113 6e-24
AB061779-1|BAB86335.1| 1095|Homo sapiens LTRPC6 protein. 113 6e-24
AK172800-1|BAD18773.1| 746|Homo sapiens 7 (Trpm7). protein. 106 5e-22
BC126342-1|AAI26343.1| 682|Homo sapiens TRPM8 protein protein. 85 2e-15
AB051552-1|BAB21856.1| 608|Homo sapiens KIAA1765 protein protein. 38 0.33
U53225-1|AAA98672.1| 522|Homo sapiens sorting nexin 1 protein. 37 0.58
BT006983-1|AAP35629.1| 522|Homo sapiens sorting nexin 1 protein. 37 0.58
BC000357-1|AAH00357.1| 522|Homo sapiens sorting nexin 1 protein. 37 0.58
AK222793-1|BAD96513.1| 522|Homo sapiens sorting nexin 1 isoform... 37 0.58
AK128179-1|BAC87312.1| 557|Homo sapiens protein ( Homo sapiens ... 37 0.58
AF065484-1|AAC17183.1| 457|Homo sapiens sorting nexin 1A protein. 37 0.58
AF065483-1|AAC17182.1| 522|Homo sapiens sorting nexin 1 protein. 37 0.58
AB209013-1|BAD92250.1| 432|Homo sapiens sorting nexin 1 isoform... 37 0.58
BC129985-1|AAI29986.1| 348|Homo sapiens KIAA0774 protein. 36 1.0
BC119655-1|AAI19656.1| 258|Homo sapiens KIAA0774 protein protein. 36 1.0
BC119654-1|AAI19655.1| 348|Homo sapiens KIAA0774 protein. 36 1.0
BC032481-1|AAH32481.1| 348|Homo sapiens KIAA0774 protein. 36 1.0
AL607144-1|CAI40565.1| 1163|Homo sapiens KIAA0774 protein. 36 1.0
AL596114-1|CAI39910.1| 1163|Homo sapiens KIAA0774 protein. 36 1.0
AL596092-1|CAI40386.1| 1163|Homo sapiens KIAA0774 protein. 36 1.0
AL160255-1|CAI41204.1| 1163|Homo sapiens KIAA0774 protein. 36 1.0
AB018317-1|BAA34494.2| 1381|Homo sapiens KIAA0774 protein protein. 36 1.0
BC011621-1|AAH11621.1| 728|Homo sapiens hook homolog 1 (Drosoph... 34 3.1
AL035416-6|CAI22779.1| 728|Homo sapiens hook homolog 1 (Drosoph... 34 3.1
AK056459-1|BAB71191.1| 331|Homo sapiens protein ( Homo sapiens ... 34 3.1
AF044923-1|AAC09298.1| 728|Homo sapiens hook1 protein protein. 34 3.1
BC127816-1|AAI27817.1| 416|Homo sapiens Unknown (protein for IM... 34 4.1
AK222561-1|BAD96281.1| 522|Homo sapiens sorting nexin 1 isoform... 34 4.1
AK097517-1|BAC05084.1| 621|Homo sapiens protein ( Homo sapiens ... 34 4.1
BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein. 33 5.4
AK125971-1|BAC86369.1| 483|Homo sapiens protein ( Homo sapiens ... 33 5.4
AB011137-1|BAA25491.2| 641|Homo sapiens KIAA0565 protein protein. 33 5.4
BC101678-1|AAI01679.1| 342|Homo sapiens C1orf113 protein protein. 33 7.2
BC101676-1|AAI01677.1| 342|Homo sapiens C1orf113 protein protein. 33 7.2
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 33 7.2
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 33 7.2
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 33 7.2
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 33 7.2
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 33 7.2
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 33 7.2
X13939-1|CAA32122.1| 328|Homo sapiens laminin B2 protein. 33 9.5
M55210-1|AAA59492.1| 1609|Homo sapiens laminin B2 chain protein. 33 9.5
M27654-1|AAA59489.1| 217|Homo sapiens laminin B2 protein. 33 9.5
J03202-1|AAA59488.1| 1609|Homo sapiens LAMB2 protein. 33 9.5
AL607144-2|CAI40566.1| 348|Homo sapiens KIAA0774 protein. 33 9.5
AL596114-2|CAI39912.1| 348|Homo sapiens KIAA0774 protein. 33 9.5
AL450304-5|CAI14877.1| 1609|Homo sapiens laminin, gamma 1 (forme... 33 9.5
AL354953-3|CAH70981.1| 1609|Homo sapiens laminin, gamma 1 (forme... 33 9.5
>AL442645-3|CAM17593.1| 1569|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1569
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 472
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 473 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 528
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 529 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 588
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 589 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 648
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 649 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 697
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 698 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 754
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 755 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 814
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 815 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 874
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 875 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 934
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 935 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 994
Query: 712 FML 714
++
Sbjct: 995 QLI 997
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 902 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 961
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 962 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1021
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1022 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1081
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1082 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1121
>AL358786-3|CAM15779.1| 1569|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1569
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 472
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 473 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 528
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 529 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 588
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 589 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 648
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 649 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 697
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 698 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 754
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 755 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 814
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 815 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 874
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 875 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 934
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 935 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 994
Query: 712 FML 714
++
Sbjct: 995 QLI 997
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 902 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 961
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 962 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1021
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1022 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1081
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1082 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1121
>AL356318-9|CAM13167.1| 1569|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1569
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 472
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 473 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 528
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 529 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 588
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 589 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 648
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 649 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 697
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 698 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 754
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 755 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 814
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 815 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 874
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 875 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 934
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 935 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 994
Query: 712 FML 714
++
Sbjct: 995 QLI 997
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 902 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 961
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 962 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1021
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1022 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1081
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1082 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1121
>AL159990-7|CAM13093.1| 1569|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1569
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 472
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 473 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 528
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 529 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 588
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 589 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 648
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 649 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 697
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 698 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 754
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 755 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 814
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 815 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 874
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 875 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 934
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 935 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 994
Query: 712 FML 714
++
Sbjct: 995 QLI 997
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 902 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 961
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 962 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1021
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1022 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1081
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1082 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1121
>AF536751-1|AAO49156.1| 1544|Homo sapiens calcium-permeable
store-operated channel TRPM3d protein.
Length = 1544
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 447
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 448 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 503
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 504 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 563
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 564 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 623
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 624 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 672
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 673 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 729
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 730 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 789
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 790 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 849
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 850 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 909
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 910 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 969
Query: 712 FML 714
++
Sbjct: 970 QLI 972
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 877 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 936
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 937 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 996
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 997 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1056
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1057 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1096
>AB099663-1|BAC55104.1| 1544|Homo sapiens hypothetical protein
protein.
Length = 1544
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 447
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 448 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 503
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 504 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 563
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 564 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 623
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 624 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 672
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 673 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 729
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 730 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 789
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 790 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 849
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 850 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 909
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 910 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 969
Query: 712 FML 714
++
Sbjct: 970 QLI 972
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 877 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 936
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 937 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 996
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 997 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1056
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1057 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1096
>AB099662-1|BAC55103.1| 1569|Homo sapiens hypothetical protein
protein.
Length = 1569
Score = 628 bits (1552), Expect = e-179
Identities = 335/723 (46%), Positives = 455/723 (62%), Gaps = 37/723 (5%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 472
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 473 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 528
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+ACKL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 529 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 588
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 589 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 648
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 649 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 697
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 698 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 754
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 755 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 814
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF
Sbjct: 815 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFV 874
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 875 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 934
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 935 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 994
Query: 712 FML 714
++
Sbjct: 995 QLI 997
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 902 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 961
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 962 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1021
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1022 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1081
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1082 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1121
>AL442645-6|CAM17596.1| 1704|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1704
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL442645-5|CAM17595.1| 1322|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1322
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL358786-6|CAM15782.1| 1704|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1704
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL358786-5|CAM15781.1| 1322|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1322
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL356318-12|CAM13169.1| 1704|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1704
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL356318-11|CAM13168.1| 1322|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1322
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL161913-2|CAM22746.1| 1704|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1704
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL161913-1|CAM22745.1| 1322|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1322
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL159990-10|CAM13096.1| 1704|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1704
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL159990-9|CAM13095.1| 1322|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1322
Score = 622 bits (1537), Expect = e-177
Identities = 336/739 (45%), Positives = 458/739 (61%), Gaps = 47/739 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 416 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 471
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 472 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 531
Query: 121 LRYILRDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----------- 168
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 532 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKA 591
Query: 169 AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQ 227
K++ ++ R T+ + + E+ F +PF+EL++WAVL KR +
Sbjct: 592 LKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQK 647
Query: 228 MALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDY 287
MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD
Sbjct: 648 MALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ 707
Query: 288 CYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKN 347
Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN
Sbjct: 708 SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN 767
Query: 348 TNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIG 406
+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 768 SGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---- 823
Query: 407 SGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWAD 466
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 824 -------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFY 873
Query: 467 SIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVW 526
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 874 TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVW 933
Query: 527 AWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGP 585
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP
Sbjct: 934 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 993
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEV
Sbjct: 994 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 1053
Query: 646 FAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXF 696
FA+Q+ PPCG + L C+ G W+ P +M+ Y F
Sbjct: 1054 FADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF 1113
Query: 697 IEVNGVSHQVF-YQPYFML 714
EV +S+QV+ +Q Y ++
Sbjct: 1114 FEVKSISNQVWKFQRYQLI 1132
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1037 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1096
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1097 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1156
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1157 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1216
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1217 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1256
>AL442645-2|CAM17592.1| 1579|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AL358786-2|CAM15778.1| 1579|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AL356318-2|CAM13164.1| 1579|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AL159990-2|CAM13091.1| 1579|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AJ505026-1|CAD43605.1| 1325|Homo sapiens long transient receptor
potential channel 3 protein.
Length = 1325
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 425 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 480
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 481 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 540
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 541 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 600
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 601 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 656
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 657 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 716
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 717 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 776
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 777 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 826
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 827 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 882
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 883 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 942
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 943 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 1002
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 1003 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 1062
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 1063 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 1122
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 1123 SNQVWKFQRYQLI 1135
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1040 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1099
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1100 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1159
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1160 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1219
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1220 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1259
>AJ505025-1|CAD43604.1| 1707|Homo sapiens long transient receptor
potential channel 3 protein.
Length = 1707
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 425 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 480
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 481 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 540
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 541 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 600
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 601 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 656
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 657 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 716
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 717 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 776
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 777 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 826
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 827 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 882
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 883 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 942
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 943 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 1002
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 1003 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 1062
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 1063 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 1122
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 1123 SNQVWKFQRYQLI 1135
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1040 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1099
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1100 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1159
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1160 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1219
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1220 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1259
>AF536753-1|AAO49158.1| 1579|Homo sapiens calcium-permeable
store-operated channel TRPM3f protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AF536748-1|AAO49153.1| 1554|Homo sapiens calcium-permeable
store-operated channel TRPM3a protein.
Length = 1554
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 910 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 969
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 970 SNQVWKFQRYQLI 982
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 946
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 947 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1006
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1007 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1066
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1106
>AB099664-1|BAC55105.1| 1579|Homo sapiens hypothetical protein
protein.
Length = 1579
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 297 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 352
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 353 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 412
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 413 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 472
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 473 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 698
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 699 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 754
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 755 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 814
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 815 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 874
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 875 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 934
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 995 SNQVWKFQRYQLI 1007
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 912 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 971
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 972 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1031
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1032 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1091
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1092 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1131
>AB099661-1|BAC55102.1| 1554|Homo sapiens hypothetical protein
protein.
Length = 1554
Score = 621 bits (1535), Expect = e-177
Identities = 335/733 (45%), Positives = 456/733 (62%), Gaps = 47/733 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMA 651
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 652 PPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGV 702
PPCG + L C+ G W+ P +M+ Y F EV +
Sbjct: 910 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 969
Query: 703 SHQVF-YQPYFML 714
S+QV+ +Q Y ++
Sbjct: 970 SNQVWKFQRYQLI 982
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 946
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 947 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1006
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1007 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1066
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1106
>AL442645-1|CAM17591.1| 1552|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1552
Score = 619 bits (1530), Expect = e-176
Identities = 336/741 (45%), Positives = 457/741 (61%), Gaps = 49/741 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 262 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 317
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 318 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 377
Query: 121 LRYILRDVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPI 167
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +
Sbjct: 378 LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTL 437
Query: 168 YAKVMN-KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKR 225
Y + K ++ R T+ + + E+ F +PF+EL++WAVL KR
Sbjct: 438 YHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKR 493
Query: 226 HQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELL 285
+MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELL
Sbjct: 494 QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 553
Query: 286 DYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTR 345
D Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR R
Sbjct: 554 DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 613
Query: 346 KNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEAL 404
KN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 614 KNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-- 671
Query: 405 IGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFW 464
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 672 ---------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFW 719
Query: 465 ADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFS 524
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K
Sbjct: 720 FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 779
Query: 525 VWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYL 583
VW WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYL
Sbjct: 780 VWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYL 839
Query: 584 GPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYG 643
GP V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YG
Sbjct: 840 GPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYG 899
Query: 644 EVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXX 694
EVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 900 EVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNN 959
Query: 695 XFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 960 TFFEVKSISNQVWKFQRYQLI 980
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 885 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 944
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 945 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1004
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1005 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1064
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1065 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1104
>AL358786-1|CAM15777.1| 1552|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1552
Score = 619 bits (1530), Expect = e-176
Identities = 336/741 (45%), Positives = 457/741 (61%), Gaps = 49/741 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 262 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 317
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 318 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 377
Query: 121 LRYILRDVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPI 167
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +
Sbjct: 378 LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTL 437
Query: 168 YAKVMN-KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKR 225
Y + K ++ R T+ + + E+ F +PF+EL++WAVL KR
Sbjct: 438 YHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKR 493
Query: 226 HQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELL 285
+MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELL
Sbjct: 494 QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 553
Query: 286 DYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTR 345
D Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR R
Sbjct: 554 DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 613
Query: 346 KNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEAL 404
KN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 614 KNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-- 671
Query: 405 IGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFW 464
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 672 ---------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFW 719
Query: 465 ADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFS 524
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K
Sbjct: 720 FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 779
Query: 525 VWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYL 583
VW WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYL
Sbjct: 780 VWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYL 839
Query: 584 GPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYG 643
GP V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YG
Sbjct: 840 GPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYG 899
Query: 644 EVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXX 694
EVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 900 EVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNN 959
Query: 695 XFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 960 TFFEVKSISNQVWKFQRYQLI 980
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 885 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 944
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 945 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1004
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1005 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1064
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1065 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1104
>AL356318-1|CAM13163.1| 1552|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1552
Score = 619 bits (1530), Expect = e-176
Identities = 336/741 (45%), Positives = 457/741 (61%), Gaps = 49/741 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 262 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 317
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 318 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 377
Query: 121 LRYILRDVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPI 167
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +
Sbjct: 378 LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTL 437
Query: 168 YAKVMN-KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKR 225
Y + K ++ R T+ + + E+ F +PF+EL++WAVL KR
Sbjct: 438 YHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKR 493
Query: 226 HQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELL 285
+MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELL
Sbjct: 494 QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 553
Query: 286 DYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTR 345
D Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR R
Sbjct: 554 DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 613
Query: 346 KNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEAL 404
KN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 614 KNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-- 671
Query: 405 IGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFW 464
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 672 ---------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFW 719
Query: 465 ADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFS 524
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K
Sbjct: 720 FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 779
Query: 525 VWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYL 583
VW WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYL
Sbjct: 780 VWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYL 839
Query: 584 GPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYG 643
GP V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YG
Sbjct: 840 GPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYG 899
Query: 644 EVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXX 694
EVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 900 EVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNN 959
Query: 695 XFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 960 TFFEVKSISNQVWKFQRYQLI 980
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 885 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 944
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 945 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1004
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1005 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1064
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1065 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1104
>AL159990-1|CAM13090.1| 1552|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1552
Score = 619 bits (1530), Expect = e-176
Identities = 336/741 (45%), Positives = 457/741 (61%), Gaps = 49/741 (6%)
Query: 1 MALLLPITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEI 60
M + ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+I
Sbjct: 262 MECMKKITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQI 317
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F+YGQ+WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNT
Sbjct: 318 FIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 377
Query: 121 LRYILRDVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPI 167
L +++RDV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +
Sbjct: 378 LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTL 437
Query: 168 YAKVMN-KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKR 225
Y + K ++ R T+ + + E+ F +PF+EL++WAVL KR
Sbjct: 438 YHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKR 493
Query: 226 HQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELL 285
+MAL W HGEE++AK+L+ACKL K + +EL H ++F A+ELL
Sbjct: 494 QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 553
Query: 286 DYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTR 345
D Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR R
Sbjct: 554 DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 613
Query: 346 KNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEAL 404
KN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 614 KNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-- 671
Query: 405 IGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFW 464
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW
Sbjct: 672 ---------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFW 719
Query: 465 ADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFS 524
++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K
Sbjct: 720 FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 779
Query: 525 VWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYL 583
VW WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYL
Sbjct: 780 VWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYL 839
Query: 584 GPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYG 643
GP V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YG
Sbjct: 840 GPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYG 899
Query: 644 EVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXX 694
EVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 900 EVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNN 959
Query: 695 XFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 960 TFFEVKSISNQVWKFQRYQLI 980
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 885 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 944
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 945 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1004
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1005 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1064
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1065 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1104
>AL442645-7|CAM17597.1| 1711|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1711
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 427 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 482
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 483 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 542
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 543 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 602
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 603 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 658
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 659 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 718
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 719 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 778
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 779 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 830
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 831 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 884
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 885 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 944
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 945 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 1004
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 1005 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 1064
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 1065 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 1124
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 1125 SISNQVWKFQRYQLI 1139
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1044 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1103
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1104 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1163
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1164 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1223
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1224 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1263
>AL391819-1|CAM23807.1| 1711|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1711
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 427 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 482
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 483 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 542
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 543 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 602
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 603 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 658
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 659 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 718
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 719 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 778
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 779 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 830
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 831 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 884
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 885 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 944
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 945 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 1004
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 1005 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 1064
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 1065 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 1124
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 1125 SISNQVWKFQRYQLI 1139
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1044 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1103
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1104 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1163
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1164 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1223
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1224 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1263
>AL358786-7|CAM15783.1| 1711|Homo sapiens transient receptor potential
cation channel, subfamily M, member 3 protein.
Length = 1711
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 427 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 482
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 483 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 542
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 543 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 602
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 603 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 658
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 659 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 718
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 719 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 778
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 779 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 830
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 831 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 884
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 885 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 944
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 945 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 1004
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 1005 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 1064
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 1065 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 1124
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 1125 SISNQVWKFQRYQLI 1139
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1044 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1103
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1104 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1163
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1164 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1223
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1224 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1263
>AL356318-13|CAM13170.1| 1711|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1711
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 427 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 482
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 483 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 542
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 543 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 602
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 603 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 658
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 659 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 718
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 719 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 778
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 779 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 830
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 831 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 884
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 885 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 944
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 945 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 1004
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 1005 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 1064
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 1065 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 1124
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 1125 SISNQVWKFQRYQLI 1139
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1044 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1103
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1104 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1163
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1164 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1223
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1224 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1263
>AL159990-11|CAM13097.1| 1711|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1711
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 427 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 482
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 483 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 542
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 543 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 602
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 603 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 658
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 659 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 718
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 719 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 778
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 779 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 830
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 831 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 884
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 885 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 944
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 945 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 1004
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 1005 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 1064
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 1065 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 1124
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 1125 SISNQVWKFQRYQLI 1139
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 1044 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 1103
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 1104 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1163
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1164 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1223
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1224 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1263
>AF536752-1|AAO49157.1| 1556|Homo sapiens calcium-permeable
store-operated channel TRPM3e protein.
Length = 1556
Score = 619 bits (1528), Expect = e-176
Identities = 335/735 (45%), Positives = 455/735 (61%), Gaps = 49/735 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y +
Sbjct: 388 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 447
Query: 174 -KSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALL 231
K ++ R T+ + + E+ F +PF+EL++WAVL KR +MAL
Sbjct: 448 PKRDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALF 503
Query: 232 MWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQ 291
W HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+Q
Sbjct: 504 FWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQ 563
Query: 292 DDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLK 351
D+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LK
Sbjct: 564 DEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 623
Query: 352 VILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGEC 410
VIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 VILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-------- 675
Query: 411 ETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAY 470
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AY
Sbjct: 676 ---MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAY 729
Query: 471 ILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNM 530
I +L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW
Sbjct: 730 IGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEY 789
Query: 531 WNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M
Sbjct: 790 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 849
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q
Sbjct: 850 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 909
Query: 650 MAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVN 700
+ PPCG + L C+ G W+ P +M+ Y F EV
Sbjct: 910 IDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 969
Query: 701 GVSHQVF-YQPYFML 714
+S+QV+ +Q Y ++
Sbjct: 970 SISNQVWKFQRYQLI 984
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 889 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 948
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 949 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1008
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1009 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1068
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1069 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1108
>AF536749-1|AAO49154.1| 1566|Homo sapiens calcium-permeable
store-operated channel TRPM3b protein.
Length = 1566
Score = 612 bits (1511), Expect = e-174
Identities = 335/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-------------HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY----- 168
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y
Sbjct: 388 DVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 447
Query: 169 ------AKVMNKSVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAV 221
K++ ++ R T+ + + E+ F +PF+EL++WAV
Sbjct: 448 PKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAV 503
Query: 222 LTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKA 281
L KR +MAL W HGEE++AK+L+ACKL K + +EL H ++F A
Sbjct: 504 LMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLA 563
Query: 282 LELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGG 341
+ELLD Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG
Sbjct: 564 VELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGR 623
Query: 342 LRTRKNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTD 400
LR RKN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ +
Sbjct: 624 LRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEE 683
Query: 401 AEALIGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPI 460
+ ++ +G+ E S R+ E R+ PL +KIYEF+ API
Sbjct: 684 ED-----------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPI 729
Query: 461 TKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIR 520
KFW ++AYI +L++F Y VLVKM PS E I YI T EK+REI+ SEP +
Sbjct: 730 VKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLL 789
Query: 521 HKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGV 579
K VW WN D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GV
Sbjct: 790 QKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGV 849
Query: 580 NKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYF 639
NKYLGP V M+GKM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+
Sbjct: 850 NKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYW 909
Query: 640 MLYGEVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
M+YGEVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 910 MIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 899 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 958
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 959 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 1018
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 1019 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1078
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1079 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AL442645-4|CAM17594.1| 1566|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1566
Score = 606 bits (1497), Expect = e-172
Identities = 334/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM- 650
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 651 -----------APPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
+ PCG + L C+ G W+ P +M+ Y
Sbjct: 910 RKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 153 bits (371), Expect = 4e-36
Identities = 80/232 (34%), Positives = 131/232 (56%), Gaps = 23/232 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID------------PPCG--------KEIGDRKCVTGRW 741
++ +FY PY+M+YGEVFA ID PCG K I C TG W
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAW 946
Query: 742 ITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPP 801
I P M Y S+QVW FQR+ ++M + ++PVLPPP
Sbjct: 947 IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPP 1006
Query: 802 LIIFCHIYAVGKWVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQE 858
LIIF H+ + + + R + D GLKLF+ +++++++DFEE+C+E YFRE++
Sbjct: 1007 LIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKD 1066
Query: 859 IKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
+ ++S +ER+R T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 DRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AL358786-4|CAM15780.1| 1566|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1566
Score = 606 bits (1497), Expect = e-172
Identities = 334/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM- 650
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 651 -----------APPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
+ PCG + L C+ G W+ P +M+ Y
Sbjct: 910 RKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 153 bits (371), Expect = 4e-36
Identities = 80/232 (34%), Positives = 131/232 (56%), Gaps = 23/232 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID------------PPCG--------KEIGDRKCVTGRW 741
++ +FY PY+M+YGEVFA ID PCG K I C TG W
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAW 946
Query: 742 ITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPP 801
I P M Y S+QVW FQR+ ++M + ++PVLPPP
Sbjct: 947 IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPP 1006
Query: 802 LIIFCHIYAVGKWVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQE 858
LIIF H+ + + + R + D GLKLF+ +++++++DFEE+C+E YFRE++
Sbjct: 1007 LIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKD 1066
Query: 859 IKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
+ ++S +ER+R T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 DRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AL356318-8|CAM13166.1| 1566|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1566
Score = 606 bits (1497), Expect = e-172
Identities = 334/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM- 650
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 651 -----------APPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
+ PCG + L C+ G W+ P +M+ Y
Sbjct: 910 RKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 153 bits (371), Expect = 4e-36
Identities = 80/232 (34%), Positives = 131/232 (56%), Gaps = 23/232 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID------------PPCG--------KEIGDRKCVTGRW 741
++ +FY PY+M+YGEVFA ID PCG K I C TG W
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAW 946
Query: 742 ITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPP 801
I P M Y S+QVW FQR+ ++M + ++PVLPPP
Sbjct: 947 IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPP 1006
Query: 802 LIIFCHIYAVGKWVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQE 858
LIIF H+ + + + R + D GLKLF+ +++++++DFEE+C+E YFRE++
Sbjct: 1007 LIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKD 1066
Query: 859 IKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
+ ++S +ER+R T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 DRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AL159990-8|CAM13094.1| 1566|Homo sapiens transient receptor
potential cation channel, subfamily M, member 3 protein.
Length = 1566
Score = 606 bits (1497), Expect = e-172
Identities = 334/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM- 650
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 651 -----------APPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
+ PCG + L C+ G W+ P +M+ Y
Sbjct: 910 RKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 153 bits (371), Expect = 4e-36
Identities = 80/232 (34%), Positives = 131/232 (56%), Gaps = 23/232 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID------------PPCG--------KEIGDRKCVTGRW 741
++ +FY PY+M+YGEVFA ID PCG K I C TG W
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAW 946
Query: 742 ITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPP 801
I P M Y S+QVW FQR+ ++M + ++PVLPPP
Sbjct: 947 IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPP 1006
Query: 802 LIIFCHIYAVGKWVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQE 858
LIIF H+ + + + R + D GLKLF+ +++++++DFEE+C+E YFRE++
Sbjct: 1007 LIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKD 1066
Query: 859 IKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
+ ++S +ER+R T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 DRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AF536750-1|AAO49155.1| 1566|Homo sapiens calcium-permeable
store-operated channel TRPM3c protein.
Length = 1566
Score = 606 bits (1497), Expect = e-172
Identities = 334/745 (44%), Positives = 456/745 (61%), Gaps = 59/745 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENGVSM +FLTI RLEELYNT+ GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 387
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIY-----------AKVMNK 174
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y K++
Sbjct: 388 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGM 447
Query: 175 SVNVH-RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
++ R T+ + + E+ F +PF+EL++WAVL KR +MAL W
Sbjct: 448 EDDIPLRRGRKTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFW 503
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
HGEE++AK+L+ACKL K + +EL H ++F A+ELLD Y+QD+
Sbjct: 504 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 563
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
A +LLT EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVI
Sbjct: 564 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 623
Query: 354 LSLLCPLYILRLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECET 412
L +L P IL LEFK+K+++ M Q +E HL E E+ E ++ TK+ + +
Sbjct: 624 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED---------- 673
Query: 413 RVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYIL 472
++ +G+ E S R+ E R+ PL +KIYEF+ API KFW ++AYI
Sbjct: 674 -MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIG 729
Query: 473 FLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWN 532
+L++F Y VLVKM PS E I YI T EK+REI+ SEP + K VW WN
Sbjct: 730 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 789
Query: 533 TYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMG 591
D I+ F VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+G
Sbjct: 790 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 849
Query: 592 KMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM- 650
KM+ +M+YF MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+
Sbjct: 850 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 909
Query: 651 -----------APPCG---------LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXX 690
+ PCG + L C+ G W+ P +M+ Y
Sbjct: 910 RKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIA 969
Query: 691 XXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 970 VFNNTFFEVKSISNQVWKFQRYQLI 994
Score = 153 bits (371), Expect = 4e-36
Identities = 80/232 (34%), Positives = 131/232 (56%), Gaps = 23/232 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID------------PPCG--------KEIGDRKCVTGRW 741
++ +FY PY+M+YGEVFA ID PCG K I C TG W
Sbjct: 887 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKIIQLPPCKTGAW 946
Query: 742 ITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPP 801
I P M Y S+QVW FQR+ ++M + ++PVLPPP
Sbjct: 947 IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPP 1006
Query: 802 LIIFCHIYAVGKWVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQE 858
LIIF H+ + + + R + D GLKLF+ +++++++DFEE+C+E YFRE++
Sbjct: 1007 LIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKD 1066
Query: 859 IKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
+ ++S +ER+R T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1067 DRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1118
>AB099665-1|BAC55106.1| 1526|Homo sapiens hypothetical protein
protein.
Length = 1526
Score = 576 bits (1421), Expect = e-163
Identities = 319/723 (44%), Positives = 437/723 (60%), Gaps = 55/723 (7%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVFR+ +EG Q++D ILTAL + + + +QLSLAL WNRVDIARS+IF+YGQ+
Sbjct: 272 ITVFRMG--SEGH--QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 327
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILR 126
WP G+L++AM+ AL DR+DFVKLL+ENG + GPSNTL +++R
Sbjct: 328 WPVGSLEQAMLDALVLDRVDFVKLLIENG------------------RHGPSNTLYHLVR 369
Query: 127 DVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-KSVNVH-RNSA 183
DV+ +LP Y +L DIGLVI L+GGAYRC YTR++FR +Y + K ++ R
Sbjct: 370 DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGR 429
Query: 184 SFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKS 243
T+ + + E+ F +PF+EL++WAVL KR +MAL W HGEE++AK+
Sbjct: 430 KTTKKREEEVDIDLD----DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 485
Query: 244 LIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCE 303
L+A KL K + +EL H ++F A+ELLD Y+QD+ A +LLT E
Sbjct: 486 LVAYKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 545
Query: 304 LQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYIL 363
L+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN+ LKVIL +L P IL
Sbjct: 546 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSIL 605
Query: 364 RLEFKSKEELQLMPQTEEEHL-ENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
LEFK+K+++ M Q +E HL E E+ E ++ TK+ + + ++ +G+
Sbjct: 606 SLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED-----------MELTAMLGR 654
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
E S R+ E R+ PL +KIYEF+ API KFW ++AYI +L++F Y VL
Sbjct: 655 NNGESS-RKKDEEEVQSKHRLIPLG--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 711
Query: 483 VKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFF 542
VKM PS E I YI T EK+REI+ SEP + K VW WN D I+ F
Sbjct: 712 VKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLF 771
Query: 543 LVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFX 601
VG+ LRL++ R GRVIYCV+IIYWY+R+L+I GVNKYLGP V M+GKM+ M+YF
Sbjct: 772 SVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIEMMYFV 831
Query: 602 XXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCG------ 655
MSFGVARQAIL P+++ SW L + +F+ PY+M+YGEVFA+Q+ PPCG
Sbjct: 832 IIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETRE 891
Query: 656 ---LPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPY 711
+ L C+ G W+ P +M+ Y F EV +S+QV+ +Q Y
Sbjct: 892 DGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY 951
Query: 712 FML 714
++
Sbjct: 952 QLI 954
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 859 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 918
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 919 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 978
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 979 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 1038
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 1039 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 1078
>AF071787-1|AAC80000.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 507 bits (1251), Expect = e-142
Identities = 285/670 (42%), Positives = 393/670 (58%), Gaps = 57/670 (8%)
Query: 71 ALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRP 130
AL++AM+ AL DR+DFVKLL+ENGV+M+ FLTIPRLEELYNT+ GP NTL ++RDV+
Sbjct: 390 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKK 449
Query: 131 -HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-------KSVNVHRNS 182
+LP Y +L DIGLV+ L+GGAYRC YTR+ FR +Y + K + + +
Sbjct: 450 SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDE 509
Query: 183 --ASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESL 240
A + ++ F YPF+EL++WAVL KR +MA+ +W GEES+
Sbjct: 510 PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESM 569
Query: 241 AKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLL 300
AK+L+ACKLYK + ++L + K+F ALELLD Y+ D+ A +LL
Sbjct: 570 AKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLL 629
Query: 301 TCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPL 360
T EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN LKVI+ +L P
Sbjct: 630 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPP 689
Query: 361 YILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKV 420
IL LEF++ ++ QT +E+ + + E++ TDA A GS + + ++N
Sbjct: 690 TILFLEFRTYDDFSY--QTSKENEDGKEKEEEN-----TDANADAGSRKGD---EEN--- 736
Query: 421 GKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYT 480
E K+ R + + KI EF+ API KFW +I+Y+ +LL+F Y
Sbjct: 737 ------------------EHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYV 778
Query: 481 VLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFII 540
+LV+M+ PS E I YI++ EKIREI+ SEP + K VW WN D I
Sbjct: 779 ILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAIS 838
Query: 541 FFLVGLTLRLR-EISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 599
F++G LRL+ + GRVIYCVDII+WY+R+L+I GVNKYLGP V M+GKM+ +M+Y
Sbjct: 839 TFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLY 898
Query: 600 FXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ-------MAP 652
F MSFGVARQAILHP++ SW L R +F+ PY+M+YGEVFA+Q + P
Sbjct: 899 FVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINP 958
Query: 653 PCGLPGLEE-------CRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQ 705
PCG +E C G W+ P +M+ Y F EV +S+Q
Sbjct: 959 PCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 1018
Query: 706 VF-YQPYFML 714
V+ +Q Y ++
Sbjct: 1019 VWKFQRYQLI 1028
Score = 170 bits (414), Expect = 3e-41
Identities = 83/234 (35%), Positives = 138/234 (58%), Gaps = 17/234 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID-------PPCGKEIGDRK------CVTGRWITPIAMT 748
++ +FY PY+M+YGEVFA ID PPCG+ + D + C+ G W+TP M
Sbjct: 928 LARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMA 987
Query: 749 VYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI 808
Y S+QVW FQR+ ++M + +PVLPPP+II HI
Sbjct: 988 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1047
Query: 809 YAVGKWVTRNVSHKRF----QYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNS 864
Y + ++ KR + D GLKLFL E+++RL++FEE+CV+ +FRE+E + +S
Sbjct: 1048 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSS 1107
Query: 865 IEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHL 918
+ER+R T++RVE+++ ++E++N++ S+Q+V+ RL +LE+++ + ++ L
Sbjct: 1108 SDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL 1161
Score = 67.7 bits (158), Expect = 3e-10
Identities = 31/63 (49%), Positives = 44/63 (69%), Gaps = 4/63 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
+TVFR+ + Q+++ ILTAL + +++ +QLSLAL WNRVDIARS+IFV+G
Sbjct: 272 VTVFRMGSEGQ----QDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPH 327
Query: 67 WPP 69
W P
Sbjct: 328 WTP 330
>AB115502-1|BAC80204.1| 1527|Homo sapiens melastatin 1 splicing
variant protein.
Length = 1527
Score = 507 bits (1251), Expect = e-142
Identities = 285/670 (42%), Positives = 393/670 (58%), Gaps = 57/670 (8%)
Query: 71 ALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRP 130
AL++AM+ AL DR+DFVKLL+ENGV+M+ FLTIPRLEELYNT+ GP NTL ++RDV+
Sbjct: 384 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKK 443
Query: 131 -HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-------KSVNVHRNS 182
+LP Y +L DIGLV+ L+GGAYRC YTR+ FR +Y + K + + +
Sbjct: 444 SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDE 503
Query: 183 --ASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESL 240
A + ++ F YPF+EL++WAVL KR +MA+ +W GEES+
Sbjct: 504 PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESM 563
Query: 241 AKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLL 300
AK+L+ACKLYK + ++L + K+F ALELLD Y+ D+ A +LL
Sbjct: 564 AKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLL 623
Query: 301 TCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPL 360
T EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN LKVI+ +L P
Sbjct: 624 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPP 683
Query: 361 YILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKV 420
IL LEF++ ++ QT +E+ + + E++ TDA A GS + + ++N
Sbjct: 684 TILFLEFRTYDDFSY--QTSKENEDGKEKEEEN-----TDANADAGSRKGD---EEN--- 730
Query: 421 GKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYT 480
E K+ R + + KI EF+ API KFW +I+Y+ +LL+F Y
Sbjct: 731 ------------------EHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYV 772
Query: 481 VLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFII 540
+LV+M+ PS E I YI++ EKIREI+ SEP + K VW WN D I
Sbjct: 773 ILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAIS 832
Query: 541 FFLVGLTLRLR-EISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 599
F++G LRL+ + GRVIYCVDII+WY+R+L+I GVNKYLGP V M+GKM+ +M+Y
Sbjct: 833 TFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLY 892
Query: 600 FXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ-------MAP 652
F MSFGVARQAILHP++ SW L R +F+ PY+M+YGEVFA+Q + P
Sbjct: 893 FVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINP 952
Query: 653 PCGLPGLEE-------CRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQ 705
PCG +E C G W+ P +M+ Y F EV +S+Q
Sbjct: 953 PCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 1012
Query: 706 VF-YQPYFML 714
V+ +Q Y ++
Sbjct: 1013 VWKFQRYQLI 1022
Score = 170 bits (414), Expect = 3e-41
Identities = 83/234 (35%), Positives = 138/234 (58%), Gaps = 17/234 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID-------PPCGKEIGDRK------CVTGRWITPIAMT 748
++ +FY PY+M+YGEVFA ID PPCG+ + D + C+ G W+TP M
Sbjct: 922 LARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMA 981
Query: 749 VYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI 808
Y S+QVW FQR+ ++M + +PVLPPP+II HI
Sbjct: 982 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1041
Query: 809 YAVGKWVTRNVSHKRF----QYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNS 864
Y + ++ KR + D GLKLFL E+++RL++FEE+CV+ +FRE+E + +S
Sbjct: 1042 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSS 1101
Query: 865 IEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHL 918
+ER+R T++RVE+++ ++E++N++ S+Q+V+ RL +LE+++ + ++ L
Sbjct: 1102 SDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL 1155
Score = 70.9 bits (166), Expect = 3e-11
Identities = 32/63 (50%), Positives = 45/63 (71%), Gaps = 4/63 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
+TVFR+ + Q+++ ILTAL + +++ +QLSLAL WNRVDIARS+IFV+G
Sbjct: 266 VTVFRMGSEGQ----QDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPH 321
Query: 67 WPP 69
WPP
Sbjct: 322 WPP 324
>AB115501-1|BAC80203.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 507 bits (1251), Expect = e-142
Identities = 285/670 (42%), Positives = 393/670 (58%), Gaps = 57/670 (8%)
Query: 71 ALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRP 130
AL++AM+ AL DR+DFVKLL+ENGV+M+ FLTIPRLEELYNT+ GP NTL ++RDV+
Sbjct: 390 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKK 449
Query: 131 -HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-------KSVNVHRNS 182
+LP Y +L DIGLV+ L+GGAYRC YTR+ FR +Y + K + + +
Sbjct: 450 SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDE 509
Query: 183 --ASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESL 240
A + ++ F YPF+EL++WAVL KR +MA+ +W GEES+
Sbjct: 510 PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESM 569
Query: 241 AKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLL 300
AK+L+ACKLYK + ++L + K+F ALELLD Y+ D+ A +LL
Sbjct: 570 AKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLL 629
Query: 301 TCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPL 360
T EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN LKVI+ +L P
Sbjct: 630 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPP 689
Query: 361 YILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKV 420
IL LEF++ ++ QT +E+ + + E++ TDA A GS + + ++N
Sbjct: 690 TILFLEFRTYDDFSY--QTSKENEDGKEKEEEN-----TDANADAGSRKGD---EEN--- 736
Query: 421 GKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYT 480
E K+ R + + KI EF+ API KFW +I+Y+ +LL+F Y
Sbjct: 737 ------------------EHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYV 778
Query: 481 VLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFII 540
+LV+M+ PS E I YI++ EKIREI+ SEP + K VW WN D I
Sbjct: 779 ILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAIS 838
Query: 541 FFLVGLTLRLR-EISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 599
F++G LRL+ + GRVIYCVDII+WY+R+L+I GVNKYLGP V M+GKM+ +M+Y
Sbjct: 839 TFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLY 898
Query: 600 FXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ-------MAP 652
F MSFGVARQAILHP++ SW L R +F+ PY+M+YGEVFA+Q + P
Sbjct: 899 FVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINP 958
Query: 653 PCGLPGLEE-------CRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQ 705
PCG +E C G W+ P +M+ Y F EV +S+Q
Sbjct: 959 PCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 1018
Query: 706 VF-YQPYFML 714
V+ +Q Y ++
Sbjct: 1019 VWKFQRYQLI 1028
Score = 170 bits (414), Expect = 3e-41
Identities = 83/234 (35%), Positives = 138/234 (58%), Gaps = 17/234 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID-------PPCGKEIGDRK------CVTGRWITPIAMT 748
++ +FY PY+M+YGEVFA ID PPCG+ + D + C+ G W+TP M
Sbjct: 928 LARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMA 987
Query: 749 VYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI 808
Y S+QVW FQR+ ++M + +PVLPPP+II HI
Sbjct: 988 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1047
Query: 809 YAVGKWVTRNVSHKRF----QYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNS 864
Y + ++ KR + D GLKLFL E+++RL++FEE+CV+ +FRE+E + +S
Sbjct: 1048 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSS 1107
Query: 865 IEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHL 918
+ER+R T++RVE+++ ++E++N++ S+Q+V+ RL +LE+++ + ++ L
Sbjct: 1108 SDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL 1161
Score = 70.9 bits (166), Expect = 3e-11
Identities = 32/63 (50%), Positives = 45/63 (71%), Gaps = 4/63 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
+TVFR+ + Q+++ ILTAL + +++ +QLSLAL WNRVDIARS+IFV+G
Sbjct: 272 VTVFRMGSEGQ----QDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPH 327
Query: 67 WPP 69
WPP
Sbjct: 328 WPP 330
>AB115499-1|BAC80201.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 507 bits (1251), Expect = e-142
Identities = 285/670 (42%), Positives = 393/670 (58%), Gaps = 57/670 (8%)
Query: 71 ALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRP 130
AL++AM+ AL DR+DFVKLL+ENGV+M+ FLTIPRLEELYNT+ GP NTL ++RDV+
Sbjct: 390 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKK 449
Query: 131 -HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-------KSVNVHRNS 182
+LP Y +L DIGLV+ L+GGAYRC YTR+ FR +Y + K + + +
Sbjct: 450 SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDE 509
Query: 183 --ASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESL 240
A + ++ F YPF+EL++WAVL KR +MA+ +W GEES+
Sbjct: 510 PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESM 569
Query: 241 AKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLL 300
AK+L+ACKLYK + ++L + K+F ALELLD Y+ D+ A +LL
Sbjct: 570 AKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLL 629
Query: 301 TCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPL 360
T EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN LKVI+ +L P
Sbjct: 630 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPP 689
Query: 361 YILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKV 420
IL LEF++ ++ QT +E+ + + E++ TDA A GS + + ++N
Sbjct: 690 TILFLEFRTYDDFSY--QTSKENEDGKEKEEEN-----TDANADAGSRKGD---EEN--- 736
Query: 421 GKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYT 480
E K+ R + + KI EF+ API KFW +I+Y+ +LL+F Y
Sbjct: 737 ------------------EHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYV 778
Query: 481 VLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFII 540
+LV+M+ PS E I YI++ EKIREI+ SEP + K VW WN D I
Sbjct: 779 ILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAIS 838
Query: 541 FFLVGLTLRLR-EISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 599
F++G LRL+ + GRVIYCVDII+WY+R+L+I GVNKYLGP V M+GKM+ +M+Y
Sbjct: 839 TFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLY 898
Query: 600 FXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ-------MAP 652
F MSFGVARQAILHP++ SW L R +F+ PY+M+YGEVFA+Q + P
Sbjct: 899 FVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINP 958
Query: 653 PCGLPGLEE-------CRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQ 705
PCG +E C G W+ P +M+ Y F EV +S+Q
Sbjct: 959 PCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 1018
Query: 706 VF-YQPYFML 714
V+ +Q Y ++
Sbjct: 1019 VWKFQRYQLI 1028
Score = 169 bits (410), Expect = 8e-41
Identities = 83/234 (35%), Positives = 137/234 (58%), Gaps = 17/234 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID-------PPCGKEIGDRK------CVTGRWITPIAMT 748
++ +FY PY+M+YGEVFA ID PPCG+ + D + C+ G W+TP M
Sbjct: 928 LARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMA 987
Query: 749 VYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI 808
Y S+QVW FQR+ ++M + +PVLPPP+II HI
Sbjct: 988 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1047
Query: 809 YAVGKWVTRNVSHKRF----QYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNS 864
Y + ++ KR + D GLKLFL E+++RL++FEE+CV+ +FRE+E + +S
Sbjct: 1048 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSS 1107
Query: 865 IEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHL 918
+ER+R T++RVE+++ +E++N++ S+Q+V+ RL +LE+++ + ++ L
Sbjct: 1108 SDERIRVTSERVENMSMGLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL 1161
Score = 70.9 bits (166), Expect = 3e-11
Identities = 32/63 (50%), Positives = 45/63 (71%), Gaps = 4/63 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
+TVFR+ + Q+++ ILTAL + +++ +QLSLAL WNRVDIARS+IFV+G
Sbjct: 272 VTVFRMGSEGQ----QDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPH 327
Query: 67 WPP 69
WPP
Sbjct: 328 WPP 330
>AB115498-1|BAC80200.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 507 bits (1251), Expect = e-142
Identities = 285/670 (42%), Positives = 393/670 (58%), Gaps = 57/670 (8%)
Query: 71 ALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRP 130
AL++AM+ AL DR+DFVKLL+ENGV+M+ FLTIPRLEELYNT+ GP NTL ++RDV+
Sbjct: 390 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKK 449
Query: 131 -HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN-------KSVNVHRNS 182
+LP Y +L DIGLV+ L+GGAYRC YTR+ FR +Y + K + + +
Sbjct: 450 SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDE 509
Query: 183 --ASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESL 240
A + ++ F YPF+EL++WAVL KR +MA+ +W GEES+
Sbjct: 510 PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESM 569
Query: 241 AKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLL 300
AK+L+ACKLYK + ++L + K+F ALELLD Y+ D+ A +LL
Sbjct: 570 AKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLL 629
Query: 301 TCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPL 360
T EL+NWS TCL LAV A HR +AH CSQ++L D+WMG LR RKN LKVI+ +L P
Sbjct: 630 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPP 689
Query: 361 YILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKV 420
IL LEF++ ++ QT +E+ + + E++ TDA A GS + + ++N
Sbjct: 690 TILFLEFRTYDDFSY--QTSKENEDGKEKEEEN-----TDANADAGSRKGD---EEN--- 736
Query: 421 GKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYT 480
E K+ R + + KI EF+ API KFW +I+Y+ +LL+F Y
Sbjct: 737 ------------------EHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYV 778
Query: 481 VLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFII 540
+LV+M+ PS E I YI++ EKIREI+ SEP + K VW WN D I
Sbjct: 779 ILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAIS 838
Query: 541 FFLVGLTLRLR-EISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 599
F++G LRL+ + GRVIYCVDII+WY+R+L+I GVNKYLGP V M+GKM+ +M+Y
Sbjct: 839 TFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLY 898
Query: 600 FXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ-------MAP 652
F MSFGVARQAILHP++ SW L R +F+ PY+M+YGEVFA+Q + P
Sbjct: 899 FVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINP 958
Query: 653 PCGLPGLEE-------CRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQ 705
PCG +E C G W+ P +M+ Y F EV +S+Q
Sbjct: 959 PCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 1018
Query: 706 VF-YQPYFML 714
V+ +Q Y ++
Sbjct: 1019 VWKFQRYQLI 1028
Score = 170 bits (414), Expect = 3e-41
Identities = 83/234 (35%), Positives = 138/234 (58%), Gaps = 17/234 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDID-------PPCGKEIGDRK------CVTGRWITPIAMT 748
++ +FY PY+M+YGEVFA ID PPCG+ + D + C+ G W+TP M
Sbjct: 928 LARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMA 987
Query: 749 VYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI 808
Y S+QVW FQR+ ++M + +PVLPPP+II HI
Sbjct: 988 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1047
Query: 809 YAVGKWVTRNVSHKRF----QYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNS 864
Y + ++ KR + D GLKLFL E+++RL++FEE+CV+ +FRE+E + +S
Sbjct: 1048 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSS 1107
Query: 865 IEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHL 918
+ER+R T++RVE+++ ++E++N++ S+Q+V+ RL +LE+++ + ++ L
Sbjct: 1108 SDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL 1161
Score = 72.1 bits (169), Expect = 1e-11
Identities = 33/63 (52%), Positives = 45/63 (71%), Gaps = 4/63 (6%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
+TVFR+ + Q+++ ILTAL + +L+ +QLSLAL WNRVDIARS+IFV+G
Sbjct: 272 VTVFRMGSEGQ----QDIEMAILTALLKGTNLSAPDQLSLALAWNRVDIARSQIFVFGPH 327
Query: 67 WPP 69
WPP
Sbjct: 328 WPP 330
>AY333285-1|AAR03490.1| 1943|Homo sapiens truncated transient receptor
potential cation channel subfamily M member 6 vari
protein.
Length = 1943
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 564 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 683
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 684 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 743
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 744 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 803
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 804 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 846
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 847 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 906
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 907 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 966
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 967 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1026
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1027 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1083
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1084 WKYNRYRYIMTYHE 1097
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1009 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1064
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1065 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1124
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1125 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1184
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1185 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1225
>AY333284-1|AAR03489.1| 2017|Homo sapiens transient receptor potential
cation channel subfamily M member 6 variant c protein.
Length = 2017
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 379 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 438
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 439 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 498
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 499 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 558
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 559 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 618
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 619 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 678
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 679 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 738
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 739 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 798
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 799 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 841
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 842 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 901
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 902 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 961
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 962 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1021
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1022 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1078
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1079 WKYNRYRYIMTYHE 1092
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1004 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1059
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1060 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1119
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1120 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1179
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1180 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1220
>AY333283-1|AAR03488.1| 2017|Homo sapiens transient receptor potential
cation channel subfamily M member 6 variant b protein.
Length = 2017
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 379 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 438
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 439 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 498
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 499 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 558
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 559 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 618
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 619 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 678
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 679 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 738
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 739 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 798
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 799 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 841
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 842 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 901
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 902 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 961
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 962 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1021
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1022 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1078
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1079 WKYNRYRYIMTYHE 1092
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1004 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1059
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1060 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1119
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1120 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1179
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1180 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1220
>AY333282-1|AAR03487.1| 2022|Homo sapiens transient receptor potential
cation channel subfamily M member 6 variant a protein.
Length = 2022
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 564 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 683
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 684 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 743
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 744 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 803
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 804 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 846
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 847 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 906
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 907 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 966
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 967 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1026
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1027 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1083
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1084 WKYNRYRYIMTYHE 1097
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1009 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1064
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1065 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1124
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1125 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1184
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1185 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1225
>AL354795-2|CAH70894.1| 2022|Homo sapiens transient receptor potential
cation channel, subfamily M, member 6 protein.
Length = 2022
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 564 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 683
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 684 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 743
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 744 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 803
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 804 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 846
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 847 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 906
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 907 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 966
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 967 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1026
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1027 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1083
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1084 WKYNRYRYIMTYHE 1097
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1009 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1064
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1065 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1124
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1125 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1184
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1185 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1225
>AL354795-1|CAH70893.1| 1133|Homo sapiens transient receptor
potential cation channel, subfamily M, member 6 protein.
Length = 1133
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 47 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 106
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 107 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 166
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 167 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 226
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 227 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 286
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 287 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 346
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 347 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 406
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 407 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 466
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 467 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 509
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 510 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 569
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 570 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 629
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 630 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 689
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 690 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 746
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 747 WKYNRYRYIMTYHE 760
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 672 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 727
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 728 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 787
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 788 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 847
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 848 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 888
>AK026281-1|BAB15429.1| 1133|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22628 fis, clone HSI06177. ).
Length = 1133
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 47 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 106
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 107 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 166
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 167 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 226
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 227 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 286
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 287 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 346
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 347 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 406
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 407 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 466
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 467 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 509
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 510 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 569
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 570 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 629
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 630 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 689
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 690 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 746
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 747 WKYNRYRYIMTYHE 760
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 672 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 727
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 728 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 787
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 788 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 847
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 848 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 888
>AF448232-1|AAM21562.1| 2022|Homo sapiens LTRPC6 channel kinase 2
protein.
Length = 2022
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 564 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 683
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 684 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 743
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 744 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 803
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 804 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 846
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 847 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 906
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 907 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 966
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 967 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1026
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1027 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1083
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1084 WKYNRYRYIMTYHE 1097
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1009 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1064
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1065 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1124
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1125 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1184
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1185 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1225
>AF350881-1|AAK31202.2| 2022|Homo sapiens channel-kinase 2 protein.
Length = 2022
Score = 506 bits (1249), Expect = e-142
Identities = 289/734 (39%), Positives = 415/734 (56%), Gaps = 52/734 (7%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTL-RYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NTL ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYT----RRKFRPIYAKVMNK--SVNVHRNSASFTR 187
GY TL DIGLV+ LIG AYR YT R + +Y K ++ S SA T
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
Query: 188 HNA----------GGLSLITGFMPVTS---------EMALFDYPFNELLMWAVLTKRHQM 228
H+ S++ S E F YP+N+LL+WAVL KR +M
Sbjct: 564 HSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
Query: 229 ALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYC 288
A+ W HGEE+ K++IAC LY+ EEL++Y K+F AL+LL+
Sbjct: 624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKA 683
Query: 289 YRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNT 348
++Q++ A LLT EL+NWS TCL LAV+ R ++H C+Q++L D+WMG L+ RKN+
Sbjct: 684 FKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNS 743
Query: 349 NLKVILSLLCPLYILRLEFKSKEELQLMPQTEE-EHLENESIEDDRSTKDPTDAEALIGS 407
LK+I+S++ P IL LEFKSK E+ +PQ+++ + + S ++ S+K+ +
Sbjct: 744 WLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE 803
Query: 408 GECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADS 467
+ ++D+N G E ++ LP +K+YEF++API KFW +
Sbjct: 804 RGHDEKLDENQHFGL---ESGHQHLP--------------WTRKVYEFYSAPIVKFWFYT 846
Query: 468 IAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTSEPVAIRHKFSVWA 527
+AY+ FL++FTYTVLV+M P PS E YI T E +REI SEP K VW
Sbjct: 847 MAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWI 906
Query: 528 WNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVDIIYWYLRILNILGVNKYLGPL 586
WN + I F G LR + GR+IYC+DII+W+ R+L+ VN++ GP
Sbjct: 907 SEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPY 966
Query: 587 VTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVF 646
VTM+ KM NM Y +SFGVAR+AIL P + SW L R++ F+PY+M+YGEV+
Sbjct: 967 VTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVY 1026
Query: 647 AEQMAPPCGLPGLEECRVGHWVPPLVMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQV 706
A ++ P C G ++ P + +VY ++++ +S+ +
Sbjct: 1027 AGEIDVCSSQP---SCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL 1083
Query: 707 F-YQ--PYFMLYGE 717
+ Y Y M Y E
Sbjct: 1084 WKYNRYRYIMTYHE 1097
Score = 142 bits (344), Expect = 8e-33
Identities = 70/221 (31%), Positives = 124/221 (56%), Gaps = 5/221 (2%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + ++PY+M+YGEV+AG+ID C + C G ++TP VY
Sbjct: 1009 LARDIVFEPYWMIYGEVYAGEIDV-CSSQ---PSCPPGSFLTPFLQAVYLFVQYIIMVNL 1064
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAVGKWVTRNVS 820
S+ +W + R+ +M Y +KP LPPPLI+ H+ + +
Sbjct: 1065 LIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAP 1124
Query: 821 HKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHIT 880
H + + D GLKL+L KED+++L+DFEE+CVE YF E+ ++ S EER+R T++RV +
Sbjct: 1125 HDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMY 1184
Query: 881 TKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVI 921
+++++N+K + S+ S++ ++ L+D++ T+ L V+
Sbjct: 1185 FQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVL 1225
>AB046836-1|BAB13442.1| 1017|Homo sapiens KIAA1616 protein protein.
Length = 1017
Score = 384 bits (944), Expect = e-105
Identities = 204/459 (44%), Positives = 278/459 (60%), Gaps = 26/459 (5%)
Query: 268 EELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAH 327
+EL H ++F A+ELLD Y+QD+ A +LLT EL+NWS TCL LAV A HR +AH
Sbjct: 1 QELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAH 60
Query: 328 PCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL-EN 386
CSQ++L D+WMG LR RKN+ LKVIL +L P IL LEFK+K+++ M Q +E HL E
Sbjct: 61 TCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEK 120
Query: 387 ESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVGKVGWEPSYRELPEYHPSEIKRMRPL 446
E+ E ++ TK+ + + ++ +G+ E S R+ E R+ PL
Sbjct: 121 EAEEPEKPTKEKEEED-----------MELTAMLGRNNGESS-RKKDEEEVQSKHRLIPL 168
Query: 447 RLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCE 506
+KIYEF+ API KFW ++AYI +L++F Y VLVKM PS E I YI T E
Sbjct: 169 G--RKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIE 226
Query: 507 KIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREIS-RDVGRVIYCVD 565
K+REI+ SEP + K VW WN D I+ F VG+ LRL++ R GRVIYCV+
Sbjct: 227 KMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVN 286
Query: 566 IIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDA 625
IIYWY+R+L+I GVNKYLGP V M+GKM+ +M+YF MSFGVARQAIL P+++
Sbjct: 287 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEP 346
Query: 626 SWHLIREVFFQPYFMLYGEVFAEQMAPPCG---------LPGLEECRVGHWVPPLVMSVY 676
SW L + +F+ PY+M+YGEVFA+Q+ PPCG + L C+ G W+ P +M+ Y
Sbjct: 347 SWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACY 406
Query: 677 XXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPYFML 714
F EV +S+QV+ +Q Y ++
Sbjct: 407 LLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLI 445
Score = 169 bits (412), Expect = 5e-41
Identities = 81/220 (36%), Positives = 132/220 (60%), Gaps = 11/220 (5%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCG--------KEIGDRKCVTGRWITPIAMTVYXXX 753
++ +FY PY+M+YGEVFA IDPPCG K I C TG WI P M Y
Sbjct: 350 LAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLV 409
Query: 754 XXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGK 813
S+QVW FQR+ ++M + ++PVLPPPLIIF H+ + +
Sbjct: 410 ANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQ 469
Query: 814 WVT---RNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVR 870
+ R + D GLKLF+ +++++++DFEE+C+E YFRE++ + ++S +ER+R
Sbjct: 470 HLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIR 529
Query: 871 NTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDI 910
T++RVE+++ ++E++N++ + S+Q+V+ RL +LED+
Sbjct: 530 VTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDL 569
>AY032950-1|AAK44211.1| 1865|Homo sapiens LTRPC7 protein.
Length = 1865
Score = 359 bits (882), Expect = 5e-98
Identities = 197/524 (37%), Positives = 289/524 (55%), Gaps = 32/524 (6%)
Query: 205 EMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXX 264
E F YP NELL+WA L KR MA +W HGEES+AK+L+ACK+Y+
Sbjct: 614 ETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVD 673
Query: 265 XVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRAL 324
EEL+ Y +F A+ELL+ +RQD+ A +LLT EL+NWS TCL LAV++ R
Sbjct: 674 DTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPF 733
Query: 325 LAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL 384
+AH C+Q++L+D+WMG L RKN+ KVILS+L P IL LE+K+K E+ +PQ+++ H
Sbjct: 734 VAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAH- 792
Query: 385 ENESIEDDRSTKDPTDAEALIGSGECETRV-DQNGKVGKVGWEPSYRELPEYHPSEIKRM 443
+ DD E + E R+ D N ++ + ++LP
Sbjct: 793 --QMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP---------- 840
Query: 444 RPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTF 503
+ +K Y F+ API KFW +++AY+ FL+++T+ VLV+M PS E I YI T+
Sbjct: 841 ----ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTY 896
Query: 504 LCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRL-------REISRD 556
EK+REI SE + K VW + +N D II F +G LR
Sbjct: 897 AIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNH 956
Query: 557 V---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGV 613
V GR+IYC++II+WY+R+L+ L VN+ GP V M+GKMV NM Y +SFGV
Sbjct: 957 VFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGV 1016
Query: 614 ARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCGLPGL--EECRVGHWVPPL 671
R+AIL+P + SW L +++ F PY+M++GEV+A ++ C + + C G W+ P
Sbjct: 1017 PRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEI-DVCANDSVIPQICGPGTWLTPF 1075
Query: 672 VMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPYFML 714
+ +VY +++V +S+ V+ YQ Y +
Sbjct: 1076 LQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFI 1119
Score = 190 bits (464), Expect = 2e-47
Identities = 99/182 (54%), Positives = 129/182 (70%), Gaps = 6/182 (3%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVF I E Q++D ILTAL + + + +QL L L W+RVDIA++ +FVYGQ+
Sbjct: 378 ITVFHIGS----DEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQ 433
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSN-TLRYIL 125
W G+L++AM+ AL DR+ FVKLL+ENGVSM KFLTIPRLEELYNTK GP+N L +++
Sbjct: 434 WLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLV 493
Query: 126 RDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHRNSAS 184
RDV+ +LP GY TL DIGLVI L+GG YRC YTR++FR IY + + RN++S
Sbjct: 494 RDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSS 553
Query: 185 FT 186
T
Sbjct: 554 ST 555
Score = 149 bits (360), Expect = 9e-35
Identities = 76/239 (31%), Positives = 130/239 (54%), Gaps = 2/239 (0%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + + PY+M++GEV+A +ID + + C G W+TP VY
Sbjct: 1032 LAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNL 1091
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSH 821
S+ VW +QR+ +M Y +KPVLPPPLII HI ++ + +
Sbjct: 1092 LIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKR--R 1149
Query: 822 KRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITT 881
K+ + +G KLFL +ED ++L+DFEE+CVE YF E++ K + EER+R T +RVE +
Sbjct: 1150 KKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCI 1209
Query: 882 KMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIHRFMATHPSLVNRGSTDTL 940
+++++ + N +S+QS++ ++ L+D++ T+ L + A+ S V+ T L
Sbjct: 1210 QIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITREL 1268
>AF346629-1|AAK19738.2| 1864|Homo sapiens channel-kinase 1 protein.
Length = 1864
Score = 359 bits (882), Expect = 5e-98
Identities = 197/524 (37%), Positives = 289/524 (55%), Gaps = 32/524 (6%)
Query: 205 EMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXX 264
E F YP NELL+WA L KR MA +W HGEES+AK+L+ACK+Y+
Sbjct: 614 ETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVD 673
Query: 265 XVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRAL 324
EEL+ Y +F A+ELL+ +RQD+ A +LLT EL+NWS TCL LAV++ R
Sbjct: 674 DTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPF 733
Query: 325 LAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL 384
+AH C+Q++L+D+WMG L RKN+ KVILS+L P IL LE+K+K E+ +PQ+++ H
Sbjct: 734 VAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAH- 792
Query: 385 ENESIEDDRSTKDPTDAEALIGSGECETRV-DQNGKVGKVGWEPSYRELPEYHPSEIKRM 443
+ DD E + E R+ D N ++ + ++LP
Sbjct: 793 --QMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP---------- 840
Query: 444 RPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTF 503
+ +K Y F+ API KFW +++AY+ FL+++T+ VLV+M PS E I YI T+
Sbjct: 841 ----ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTY 896
Query: 504 LCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRL-------REISRD 556
EK+REI SE + K VW + +N D II F +G LR
Sbjct: 897 AIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNH 956
Query: 557 V---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGV 613
V GR+IYC++II+WY+R+L+ L VN+ GP V M+GKMV NM Y +SFGV
Sbjct: 957 VFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGV 1016
Query: 614 ARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQMAPPCGLPGL--EECRVGHWVPPL 671
R+AIL+P + SW L +++ F PY+M++GEV+A ++ C + + C G W+ P
Sbjct: 1017 PRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEI-DVCANDSVIPQICGPGTWLTPF 1075
Query: 672 VMSVYXXXXXXXXXXXXXXXXXXXFIEVNGVSHQVF-YQPYFML 714
+ +VY +++V +S+ V+ YQ Y +
Sbjct: 1076 LQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFI 1119
Score = 190 bits (464), Expect = 2e-47
Identities = 99/182 (54%), Positives = 129/182 (70%), Gaps = 6/182 (3%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVF I E Q++D ILTAL + + + +QL L L W+RVDIA++ +FVYGQ+
Sbjct: 378 ITVFHIGS----DEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQ 433
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSN-TLRYIL 125
W G+L++AM+ AL DR+ FVKLL+ENGVSM KFLTIPRLEELYNTK GP+N L +++
Sbjct: 434 WLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLV 493
Query: 126 RDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHRNSAS 184
RDV+ +LP GY TL DIGLVI L+GG YRC YTR++FR IY + + RN++S
Sbjct: 494 RDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSS 553
Query: 185 FT 186
T
Sbjct: 554 ST 555
Score = 149 bits (360), Expect = 9e-35
Identities = 76/239 (31%), Positives = 130/239 (54%), Gaps = 2/239 (0%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPPCGKEIGDRKCVTGRWITPIAMTVYXXXXXXXXXXX 761
++ + + PY+M++GEV+A +ID + + C G W+TP VY
Sbjct: 1032 LAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNL 1091
Query: 762 XXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSH 821
S+ VW +QR+ +M Y +KPVLPPPLII HI ++ + +
Sbjct: 1092 LIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKR--R 1149
Query: 822 KRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITT 881
K+ + +G KLFL +ED ++L+DFEE+CVE YF E++ K + EER+R T +RVE +
Sbjct: 1150 KKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCI 1209
Query: 882 KMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIHRFMATHPSLVNRGSTDTL 940
+++++ + N +S+QS++ ++ L+D++ T+ L + A+ S V+ T L
Sbjct: 1210 QIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITREL 1268
>BC051024-1|AAH51024.1| 535|Homo sapiens TRPM7 protein protein.
Length = 535
Score = 295 bits (723), Expect = 9e-79
Identities = 161/401 (40%), Positives = 228/401 (56%), Gaps = 28/401 (6%)
Query: 205 EMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXX 264
E F YP NELL+WA L KR MA +W HGEES+AK+L+ACK+Y+
Sbjct: 151 ETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVD 210
Query: 265 XVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRAL 324
EEL+ Y +F A+ELL+ +RQD+ A +LLT EL+NWS TCL LAV++ R
Sbjct: 211 DTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPF 270
Query: 325 LAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCPLYILRLEFKSKEELQLMPQTEEEHL 384
+AH C+Q++L+D+WMG L RKN+ KVILS+L P IL LE+K+K E+ +PQ+++ H
Sbjct: 271 VAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAH- 329
Query: 385 ENESIEDDRSTKDPTDAEALIGSGECETRV-DQNGKVGKVGWEPSYRELPEYHPSEIKRM 443
+ DD E + E R+ D N ++ + ++LP
Sbjct: 330 --QMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP---------- 377
Query: 444 RPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTF 503
+ +K Y F+ API KFW +++AY+ FL+++T+ VLV+M PS E I YI T+
Sbjct: 378 ----ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTY 433
Query: 504 LCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRL-------REISRD 556
EK+REI SE + K VW + +N D II F +G LR
Sbjct: 434 AIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNH 493
Query: 557 V---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMV 594
V GR+IYC++II+WY+R+L+ L VN+ GP V M+GKMV
Sbjct: 494 VFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 534
Score = 102 bits (244), Expect = 1e-20
Identities = 52/92 (56%), Positives = 66/92 (71%), Gaps = 2/92 (2%)
Query: 97 SMRKFLTIPRLEELYNTKSGPSNTLRY-ILRDVRP-HLPKGYVYTLHDIGLVINKLIGGA 154
SM KFLTIPRLEELYNTK GP+N + + ++RDV+ +LP GY TL DIGLVI L+GG
Sbjct: 1 SMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGT 60
Query: 155 YRCYYTRRKFRPIYAKVMNKSVNVHRNSASFT 186
YRC YTR++FR IY + + RN++S T
Sbjct: 61 YRCTYTRKRFRLIYNSLGGNNRRSGRNTSSST 92
>BC093789-1|AAH93789.1| 1165|Homo sapiens transient receptor
potential cation channel, subfamily M, member 5 protein.
Length = 1165
Score = 245 bits (599), Expect = 1e-63
Identities = 188/652 (28%), Positives = 307/652 (47%), Gaps = 56/652 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV+ ++ EG E ELD VIL AL +A E +L LA+ W+RVDIA+SEI
Sbjct: 313 LTVYDFEQ--EGSE--ELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEI 368
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F EW L+E M+ AL ++ +FV+L ++NG + FLT RL+ELY + S S
Sbjct: 369 FNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS-- 426
Query: 121 LRYILRDVRPHLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHR 180
+L D+ + TL +G + + R + + + ++
Sbjct: 427 ---LLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQ 483
Query: 181 NSASFTRHNA--GGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEE 238
+ R A G TG + + P+ +L +WAVL RH+MA W G+E
Sbjct: 484 DGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQE 543
Query: 239 SLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQ 298
+A +L ACK+ K E ++E AL+L CY + +A
Sbjct: 544 GVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYSNSEARAFA 597
Query: 299 LLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLC 358
LL + WS TCL LA A+ +A AH Q L +W G + L+++ + LC
Sbjct: 598 LLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPI-LRLLGAFLC 656
Query: 359 PLYILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNG 418
P + EE L +T E L+ D + D T+ L G ++RV++
Sbjct: 657 PALVYTNLITFSEEAPL--RTGLEDLQ------DLDSLD-TEKSPLYG---LQSRVEE-- 702
Query: 419 KVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFT 478
E P + R + L + +F+ AP+T F + + Y FL +FT
Sbjct: 703 ----------LVEAPRAQGD--RGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT 750
Query: 479 YTVLVKMNPTP---SWPEIYSICYILTFLCEKIRE-IVTSEPVAIRHKFSVWAWNMWNTY 534
Y +LV P P S PE+ ++ T + E+IR+ T E + KF+++ + WN
Sbjct: 751 YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKC 810
Query: 535 DAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMV 594
D I F+VG+T R+ + + GR + +D + + LR+++I ++K LGP + ++ +M+
Sbjct: 811 DMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM 870
Query: 595 KNMIYFXXXXXXXXMSFGVARQAILHP-DKDASWHLIREVFFQPYFMLYGEV 645
K++ +F +++GV QA+LHP D W + R V ++PY ++G++
Sbjct: 871 KDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEW-IFRRVLYRPYLQIFGQI 921
Score = 53.2 bits (122), Expect = 6e-06
Identities = 41/208 (19%), Positives = 86/208 (41%), Gaps = 15/208 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP---CGKE---IGDR-KCVT--GRWITPIAMTVYXX 752
+ +V Y+PY ++G++ +ID C + D C + W+ + + +
Sbjct: 905 IFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLL 964
Query: 753 XXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAV 811
+ W FQR+ +++EY ++P L PP I+ H+ +
Sbjct: 965 VTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTL 1024
Query: 812 GKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRN 871
+ + HKR + L L+ +++ +E E + + E + +S E +R
Sbjct: 1025 RRVFKKEAEHKREHLERDLPDPLD----QKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
Query: 872 TTDRVEHITTKMEDLNQKANCQIQSMQS 899
T RV+ I + L ++ +I+ ++S
Sbjct: 1081 TAHRVDFIAKYLGGLREQEK-RIKCLES 1107
>BC093787-1|AAH93787.1| 1165|Homo sapiens transient receptor
potential cation channel, subfamily M, member 5 protein.
Length = 1165
Score = 245 bits (599), Expect = 1e-63
Identities = 188/652 (28%), Positives = 307/652 (47%), Gaps = 56/652 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV+ ++ EG E ELD VIL AL +A E +L LA+ W+RVDIA+SEI
Sbjct: 313 LTVYDFEQ--EGSE--ELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEI 368
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F EW L+E M+ AL ++ +FV+L ++NG + FLT RL+ELY + S S
Sbjct: 369 FNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS-- 426
Query: 121 LRYILRDVRPHLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHR 180
+L D+ + TL +G + + R + + + ++
Sbjct: 427 ---LLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQ 483
Query: 181 NSASFTRHNA--GGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEE 238
+ R A G TG + + P+ +L +WAVL RH+MA W G+E
Sbjct: 484 DGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQE 543
Query: 239 SLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQ 298
+A +L ACK+ K E ++E AL+L CY + +A
Sbjct: 544 GVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYSNSEARAFA 597
Query: 299 LLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLC 358
LL + WS TCL LA A+ +A AH Q L +W G + L+++ + LC
Sbjct: 598 LLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPI-LRLLGAFLC 656
Query: 359 PLYILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNG 418
P + EE L +T E L+ D + D T+ L G ++RV++
Sbjct: 657 PALVYTNLITFSEEAPL--RTGLEDLQ------DLDSLD-TEKSPLYG---LQSRVEE-- 702
Query: 419 KVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFT 478
E P + R + L + +F+ AP+T F + + Y FL +FT
Sbjct: 703 ----------LVEAPRAQGD--RGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT 750
Query: 479 YTVLVKMNPTP---SWPEIYSICYILTFLCEKIRE-IVTSEPVAIRHKFSVWAWNMWNTY 534
Y +LV P P S PE+ ++ T + E+IR+ T E + KF+++ + WN
Sbjct: 751 YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKC 810
Query: 535 DAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMV 594
D I F+VG+T R+ + + GR + +D + + LR+++I ++K LGP + ++ +M+
Sbjct: 811 DMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM 870
Query: 595 KNMIYFXXXXXXXXMSFGVARQAILHP-DKDASWHLIREVFFQPYFMLYGEV 645
K++ +F +++GV QA+LHP D W + R V ++PY ++G++
Sbjct: 871 KDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEW-IFRRVLYRPYLQIFGQI 921
Score = 53.2 bits (122), Expect = 6e-06
Identities = 41/208 (19%), Positives = 86/208 (41%), Gaps = 15/208 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP---CGKE---IGDR-KCVT--GRWITPIAMTVYXX 752
+ +V Y+PY ++G++ +ID C + D C + W+ + + +
Sbjct: 905 IFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLL 964
Query: 753 XXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAV 811
+ W FQR+ +++EY ++P L PP I+ H+ +
Sbjct: 965 VTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTL 1024
Query: 812 GKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRN 871
+ + HKR + L L+ +++ +E E + + E + +S E +R
Sbjct: 1025 RRVFKKEAEHKREHLERDLPDPLD----QKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
Query: 872 TTDRVEHITTKMEDLNQKANCQIQSMQS 899
T RV+ I + L ++ +I+ ++S
Sbjct: 1081 TAHRVDFIAKYLGGLREQEK-RIKCLES 1107
>AJ270996-1|CAB66342.1| 1159|Homo sapiens LTRPC5 protein protein.
Length = 1159
Score = 245 bits (599), Expect = 1e-63
Identities = 188/652 (28%), Positives = 307/652 (47%), Gaps = 56/652 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV+ ++ EG E ELD VIL AL +A E +L LA+ W+RVDIA+SEI
Sbjct: 307 LTVYDFEQ--EGSE--ELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEI 362
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F EW L+E M+ AL ++ +FV+L ++NG + FLT RL+ELY + S S
Sbjct: 363 FNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS-- 420
Query: 121 LRYILRDVRPHLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHR 180
+L D+ + TL +G + + R + + + ++
Sbjct: 421 ---LLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQ 477
Query: 181 NSASFTRHNA--GGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEE 238
+ R A G TG + + P+ +L +WAVL RH+MA W G+E
Sbjct: 478 DGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQE 537
Query: 239 SLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQ 298
+A +L ACK+ K E ++E AL+L CY + +A
Sbjct: 538 GVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYSNSEARAFA 591
Query: 299 LLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLC 358
LL + WS TCL LA A+ +A AH Q L +W G + L+++ + LC
Sbjct: 592 LLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPI-LRLLGAFLC 650
Query: 359 PLYILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNG 418
P + EE L +T E L+ D + D T+ L G ++RV++
Sbjct: 651 PALVYTNLITFSEEAPL--RTGLEDLQ------DLDSLD-TEKSPLYG---LQSRVEE-- 696
Query: 419 KVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFT 478
E P + R + L + +F+ AP+T F + + Y FL +FT
Sbjct: 697 ----------LVEAPRAQGD--RGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT 744
Query: 479 YTVLVKMNPTP---SWPEIYSICYILTFLCEKIRE-IVTSEPVAIRHKFSVWAWNMWNTY 534
Y +LV P P S PE+ ++ T + E+IR+ T E + KF+++ + WN
Sbjct: 745 YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKC 804
Query: 535 DAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMV 594
D I F+VG+T R+ + + GR + +D + + LR+++I ++K LGP + ++ +M+
Sbjct: 805 DMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM 864
Query: 595 KNMIYFXXXXXXXXMSFGVARQAILHP-DKDASWHLIREVFFQPYFMLYGEV 645
K++ +F +++GV QA+LHP D W + R V ++PY ++G++
Sbjct: 865 KDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEW-IFRRVLYRPYLQIFGQI 915
Score = 53.2 bits (122), Expect = 6e-06
Identities = 41/208 (19%), Positives = 86/208 (41%), Gaps = 15/208 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP---CGKE---IGDR-KCVT--GRWITPIAMTVYXX 752
+ +V Y+PY ++G++ +ID C + D C + W+ + + +
Sbjct: 899 IFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLL 958
Query: 753 XXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAV 811
+ W FQR+ +++EY ++P L PP I+ H+ +
Sbjct: 959 VTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTL 1018
Query: 812 GKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRN 871
+ + HKR + L L+ +++ +E E + + E + +S E +R
Sbjct: 1019 RRVFKKEAEHKREHLERDLPDPLD----QKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1074
Query: 872 TTDRVEHITTKMEDLNQKANCQIQSMQS 899
T RV+ I + L ++ +I+ ++S
Sbjct: 1075 TAHRVDFIAKYLGGLREQEK-RIKCLES 1101
>AF177473-1|AAF26288.1| 1165|Homo sapiens MTR1 protein.
Length = 1165
Score = 245 bits (599), Expect = 1e-63
Identities = 188/652 (28%), Positives = 307/652 (47%), Gaps = 56/652 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV+ ++ EG E ELD VIL AL +A E +L LA+ W+RVDIA+SEI
Sbjct: 313 LTVYDFEQ--EGSE--ELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEI 368
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT 120
F EW L+E M+ AL ++ +FV+L ++NG + FLT RL+ELY + S S
Sbjct: 369 FNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS-- 426
Query: 121 LRYILRDVRPHLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHR 180
+L D+ + TL +G + + R + + + ++
Sbjct: 427 ---LLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQ 483
Query: 181 NSASFTRHNA--GGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEE 238
+ R A G TG + + P+ +L +WAVL RH+MA W G+E
Sbjct: 484 DGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQE 543
Query: 239 SLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQ 298
+A +L ACK+ K E ++E AL+L CY + +A
Sbjct: 544 GVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYSNSEARAFA 597
Query: 299 LLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLC 358
LL + WS TCL LA A+ +A AH Q L +W G + L+++ + LC
Sbjct: 598 LLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPI-LRLLGAFLC 656
Query: 359 PLYILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNG 418
P + EE L +T E L+ D + D T+ L G ++RV++
Sbjct: 657 PALVYTNLITFSEEAPL--RTGLEDLQ------DLDSLD-TEKSPLYG---LQSRVEE-- 702
Query: 419 KVGKVGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFT 478
E P + R + L + +F+ AP+T F + + Y FL +FT
Sbjct: 703 ----------LVEAPRAQGD--RGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT 750
Query: 479 YTVLVKMNPTP---SWPEIYSICYILTFLCEKIRE-IVTSEPVAIRHKFSVWAWNMWNTY 534
Y +LV P P S PE+ ++ T + E+IR+ T E + KF+++ + WN
Sbjct: 751 YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKC 810
Query: 535 DAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMV 594
D I F+VG+T R+ + + GR + +D + + LR+++I ++K LGP + ++ +M+
Sbjct: 811 DMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM 870
Query: 595 KNMIYFXXXXXXXXMSFGVARQAILHP-DKDASWHLIREVFFQPYFMLYGEV 645
K++ +F +++GV QA+LHP D W + R V ++PY ++G++
Sbjct: 871 KDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEW-IFRRVLYRPYLQIFGQI 921
Score = 53.2 bits (122), Expect = 6e-06
Identities = 41/208 (19%), Positives = 86/208 (41%), Gaps = 15/208 (7%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP---CGKE---IGDR-KCVT--GRWITPIAMTVYXX 752
+ +V Y+PY ++G++ +ID C + D C + W+ + + +
Sbjct: 905 IFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLL 964
Query: 753 XXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHI-YAV 811
+ W FQR+ +++EY ++P L PP I+ H+ +
Sbjct: 965 VTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTL 1024
Query: 812 GKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRN 871
+ + HKR + L L+ +++ +E E + + E + +S E +R
Sbjct: 1025 RRVFKKEAEHKREHLERDLPDPLD----QKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080
Query: 872 TTDRVEHITTKMEDLNQKANCQIQSMQS 899
T RV+ I + L ++ +I+ ++S
Sbjct: 1081 TAHRVDFIAKYLGGLREQEK-RIKCLES 1107
>BC132727-1|AAI32728.1| 1214|Homo sapiens transient receptor
potential cation channel, subfamily M, member 4 protein.
Length = 1214
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 371 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 488
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 489 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 545
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 546 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 593
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 594 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 649
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 650 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 708
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 709 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 758
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 759 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 802
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 803 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 862
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 863 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 922
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 923 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 982
Query: 650 M 650
M
Sbjct: 983 M 983
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 962 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 1021
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 1022 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 1081
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 1082 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 1141
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 1142 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1190
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1191 EAL-SRSALLPPG-----GPPPP 1207
>AY297045-1|AAP44474.1| 1214|Homo sapiens transient receptor
potential cation channel subfamily M member 4 splice
variant protein.
Length = 1214
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 371 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 488
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 489 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 545
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 546 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 593
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 594 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 649
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 650 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 708
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 709 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 758
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 759 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 802
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 803 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 862
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 863 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 922
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 923 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 982
Query: 650 M 650
M
Sbjct: 983 M 983
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 962 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 1021
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 1022 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 1081
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 1082 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 1141
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 1142 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1190
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1191 EAL-SRSALLPPG-----GPPPP 1207
>AY297044-1|AAP44473.1| 1040|Homo sapiens transient receptor
potential cation channel subfamily M member 4 splice
variant protein.
Length = 1040
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 197 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 256
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 257 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 314
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 315 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 371
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 372 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 419
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 420 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 475
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 476 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 534
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 535 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 584
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 585 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 628
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 629 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 688
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 689 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 748
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 749 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 808
Query: 650 M 650
M
Sbjct: 809 M 809
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 788 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 847
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 848 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 907
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 908 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 967
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 968 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1016
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1017 EAL-SRSALLPPG-----GPPPP 1033
>AY046396-1|AAL02142.1| 1040|Homo sapiens TRP-related cation influx
channel protein.
Length = 1040
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 197 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 256
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 257 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 314
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 315 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 371
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 372 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 419
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 420 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 475
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 476 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 534
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 535 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 584
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 585 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 628
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 629 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 688
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 689 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 748
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 749 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 808
Query: 650 M 650
M
Sbjct: 809 M 809
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 788 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 847
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 848 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 907
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 908 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 967
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 968 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1016
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1017 EAL-SRSALLPPG-----GPPPP 1033
>AK000048-1|BAA90907.1| 1016|Homo sapiens protein ( Homo sapiens
cDNA FLJ20041 fis, clone COL00423. ).
Length = 1016
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 197 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 256
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 257 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 314
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 315 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 371
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 372 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 419
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 420 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 475
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 476 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 534
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 535 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 584
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 585 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 628
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 629 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 688
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 689 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 748
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 749 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 808
Query: 650 M 650
M
Sbjct: 809 M 809
Score = 46.4 bits (105), Expect = 7e-04
Identities = 37/195 (18%), Positives = 73/195 (37%), Gaps = 19/195 (9%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 788 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 847
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 848 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 907
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 908 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 967
Query: 863 NSIEERVRNTTDRVE 877
S ER+ T+ +V+
Sbjct: 968 ESDSERLERTSQKVD 982
>AJ575813-1|CAE05941.1| 1214|Homo sapiens transient receptor
potential ion channel melastatin subgroup member 4
protein protein.
Length = 1214
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 371 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 488
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 489 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 545
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 546 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 593
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 594 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 649
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 650 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 708
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 709 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 758
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 759 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 802
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 803 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 862
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 863 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 922
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 923 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 982
Query: 650 M 650
M
Sbjct: 983 M 983
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 962 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 1021
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 1022 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 1081
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 1082 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 1141
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 1142 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1190
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1191 EAL-SRSALLPPG-----GPPPP 1207
>AF497623-1|AAM18083.1| 1214|Homo sapiens cation channel TRPM4B
protein.
Length = 1214
Score = 228 bits (557), Expect = 1e-58
Identities = 181/661 (27%), Positives = 313/661 (47%), Gaps = 80/661 (12%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 371 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 488
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 489 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 545
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 546 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 593
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 594 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 649
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 650 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI-WALVLAFFCPPLIYTRLI 708
Query: 366 EFKSKEELQLMPQTEEEHLENESI---EDDRSTKDPTDAEALIGSGECETRVDQNGKVGK 422
F+ EE P EE + +S+ E T DP + L G Q+G+ G
Sbjct: 709 TFRKSEE---EPTREELEFDMDSVINGEGPVGTADPAEKTPL-GVPR------QSGRPGC 758
Query: 423 VGWEPSYRELPEYHPSEIKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVL 482
G R R ++ + F+ AP+T F + ++Y+LFLL+F+ +L
Sbjct: 759 CGGRCGGR----------------RCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLL 802
Query: 483 VKMNPTPSWP-EIYSICYILTFLCEKIRE--------IVTSEP----VAIRHKFSVWAWN 529
V P P E+ + T LCE++R+ + + P ++ + ++ +
Sbjct: 803 VDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD 862
Query: 530 MWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTM 589
WN D + FL+G+ RL +GR + C+D + + +R+L+I VNK LGP + +
Sbjct: 863 SWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 922
Query: 590 MGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEVFAEQ 649
+ KM+K++ +F +++GVA + +L P ++R VF++PY ++G++ E
Sbjct: 923 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 982
Query: 650 M 650
M
Sbjct: 983 M 983
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 962 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 1021
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 1022 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 1081
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 1082 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 1141
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 1142 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1190
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1191 EAL-SRSALLPPG-----GPPPP 1207
>AK000124-1|BAA90958.1| 575|Homo sapiens protein ( Homo sapiens
cDNA FLJ20117 fis, clone COL05727. ).
Length = 575
Score = 190 bits (464), Expect = 2e-47
Identities = 99/182 (54%), Positives = 129/182 (70%), Gaps = 6/182 (3%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQE 66
ITVF I E Q++D ILTAL + + + +QL L L W+RVDIA++ +FVYGQ+
Sbjct: 378 ITVFHIGS----DEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQ 433
Query: 67 WPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSN-TLRYIL 125
W G+L++AM+ AL DR+ FVKLL+ENGVSM KFLTIPRLEELYNTK GP+N L +++
Sbjct: 434 WLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLV 493
Query: 126 RDVRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHRNSAS 184
RDV+ +LP GY TL DIGLVI L+GG YRC YTR++FR IY + + RN++S
Sbjct: 494 RDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSS 553
Query: 185 FT 186
T
Sbjct: 554 ST 555
>AY333286-1|AAR03491.1| 973|Homo sapiens M6-kinase 1 protein.
Length = 973
Score = 184 bits (447), Expect = 3e-45
Identities = 92/171 (53%), Positives = 121/171 (70%), Gaps = 2/171 (1%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT-LRYILRDVRPH-LP 133
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NT L ++++DV+ H L
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
Query: 134 KGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVHRNSAS 184
GY TL DIGLV+ LIG AYR YTR+ FR +Y + K + N+ S
Sbjct: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKIITVNACS 554
>AY333287-1|AAR03492.1| 855|Homo sapiens M6-kinase 2 protein.
Length = 855
Score = 147 bits (357), Expect = 2e-34
Identities = 71/137 (51%), Positives = 97/137 (70%), Gaps = 1/137 (0%)
Query: 16 AEGGEVQELDQVILTALFRAQHLTPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEA 75
A+ E Q+LD ILTAL + +L+ SEQL+LA+ W+RVDIA+ I +Y Q W P AL++A
Sbjct: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
Query: 76 MMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNT-LRYILRDVRPHLPK 134
M AL DR+DFVKLL+E GV++ +FLTIPRLEELYNTK GP+NT L ++++DV+ L K
Sbjct: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQDLSK 503
Query: 135 GYVYTLHDIGLVINKLI 151
++ L N L+
Sbjct: 504 NSLWNSRSTNLNRNSLL 520
>DQ012935-1|AAY22174.1| 1503|Homo sapiens transient receptor
potential cation channel, subfamily M, member 2 protein.
Length = 1503
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 59.7 bits (138), Expect = 7e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1140 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 1193
Query: 921 IHR 923
I R
Sbjct: 1194 IVR 1196
>BC112342-1|AAI12343.1| 1553|Homo sapiens TRPM2 protein protein.
Length = 1553
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 53.2 bits (122), Expect = 6e-06
Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 3/135 (2%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDR 875
E+++ + +++
Sbjct: 1140 QKQRPEQKIEDISNK 1154
>AY603182-1|AAT12288.1| 846|Homo sapiens TRPM2-S protein.
Length = 846
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 53.6 bits (123), Expect = 5e-06
Identities = 20/56 (35%), Positives = 34/56 (60%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIRE 510
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R+
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQ 846
>AP001754-4|BAA95563.1| 1503|Homo sapiens transient receptor
potential-related channel 7, a novel putative Ca2+
channel p protein.
Length = 1503
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 60.1 bits (139), Expect = 5e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1140 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTAQALHW 1193
Query: 921 IHR 923
I R
Sbjct: 1194 IVR 1196
>AJ878416-1|CAI47593.1| 1503|Homo sapiens transient receptor
potential cation channel, subfamily M, member 2 protein.
Length = 1503
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 59.7 bits (138), Expect = 7e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1140 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 1193
Query: 921 IHR 923
I R
Sbjct: 1194 IVR 1196
>AB166746-1|BAD83706.1| 1289|Homo sapiens transient receptor
potential cation channel, subfamily M, member 2,
striatum sh protein.
Length = 1289
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 202 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 257
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 258 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 317
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 318 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 376
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 377 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 428
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 429 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 484
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 485 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 544
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 545 CMLAFPLLLTGLISFREK 562
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 577 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 636
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 637 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 696
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 697 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 755
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 756 AVYHSYLTIFGQI 768
Score = 59.7 bits (138), Expect = 7e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 809 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 868
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 869 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 925
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 926 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 979
Query: 921 IHR 923
I R
Sbjct: 980 IVR 982
>AB166745-1|BAD83705.1| 1503|Homo sapiens transient receptor
potential cation channel, subfamily M, member 2, long
form ( protein.
Length = 1503
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 59.7 bits (138), Expect = 7e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1140 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 1193
Query: 921 IHR 923
I R
Sbjct: 1194 IVR 1196
>AB001535-1|BAA34700.1| 1503|Homo sapiens KNP3 protein.
Length = 1503
Score = 147 bits (356), Expect = 3e-34
Identities = 109/378 (28%), Positives = 176/378 (46%), Gaps = 31/378 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGP-- 117
IF+ +W P L M AL ++ +FVKL LENGV +++F+T L LY
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 118 --SNTLRYILRDV-RPHL-PKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMN 173
S + ++ D RP P +H + V+ +L+G + Y R + ++
Sbjct: 532 FHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL- 590
Query: 174 KSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMW 233
+ N G+SL + + + + P +LL+WA++ R ++A ++W
Sbjct: 591 --------PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIW 642
Query: 234 THGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDD 293
++ +A +L K+ K EE+ +E+E++A+ + CYR+D+
Sbjct: 643 AQSQDCIAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDE 698
Query: 294 DQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVI 353
++AQ+LLT + W TCL LA+ A ++H Q L +W G L +
Sbjct: 699 ERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTL 758
Query: 354 LSLLCPLYILRL-EFKSK 370
L PL + L F+ K
Sbjct: 759 CMLAFPLLLTGLISFREK 776
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 850
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 851 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 910
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 911 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 969
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 970 AVYHSYLTIFGQI 982
Score = 59.7 bits (138), Expect = 7e-08
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1083 PFILLSHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1139
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1140 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 1193
Query: 921 IHR 923
I R
Sbjct: 1194 IVR 1196
>AJ417076-1|CAD01139.1| 1449|Homo sapiens putative TRP cation
channel protein.
Length = 1449
Score = 143 bits (346), Expect = 5e-33
Identities = 105/372 (28%), Positives = 173/372 (46%), Gaps = 39/372 (10%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQ-------HLTPSEQLSLALTWNRVDIARSE 59
+TVFR + G+ Q++D IL AL +A H QL LA+ WNRVDIARSE
Sbjct: 416 LTVFR---EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 60 IFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSN 119
IF+ +W P L M AL ++ +FVKL LENGV +++F+T +
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTW--------------D 517
Query: 120 TLRYILRDVRPHLPKGYVYTLHDIGLVINKLIGGAYRCYYTRRKFRPIYAKVMNKSVNVH 179
TL Y+ ++ P +H + V+ +L+G + Y R + ++
Sbjct: 518 TLLYLYENLDPSCLFHSKLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL------- 570
Query: 180 RNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEES 239
+ N G+SL + + + + P +LL+WA++ R ++A ++W ++
Sbjct: 571 --PVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDC 628
Query: 240 LAKSLIACKLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQL 299
+A +L K+ K EE+ +E+E++A+ + CYR+D+++AQ+L
Sbjct: 629 IAAALACSKILKELSKEEEDTDSS----EEMLALAEEYEHRAIGVFTECYRKDEERAQKL 684
Query: 300 LTCELQNWSGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP 359
LT + W TCL LA+ A ++H Q L +W G L + L P
Sbjct: 685 LTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFP 744
Query: 360 LYILRL-EFKSK 370
L + L F+ K
Sbjct: 745 LLLTGLISFREK 756
Score = 131 bits (317), Expect = 1e-29
Identities = 63/193 (32%), Positives = 111/193 (57%), Gaps = 3/193 (1%)
Query: 455 FFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSICYILTFLCEKIREIVTS 514
FFTAP+ F + ++Y FL +F Y ++V P PSW E ++ + +CE++R++
Sbjct: 771 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYD 830
Query: 515 -EPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDVGRVIYCVDIIYWYLRI 573
+ + K +++ + WN D G I+ F+ GLT RL + GRVI +D I + LR+
Sbjct: 831 PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRL 890
Query: 574 LNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAIL-HPDKDASWHLIRE 632
++I ++K LGP + ++ +M+K++ +F +SFGVA+QAIL H ++ W L R
Sbjct: 891 MHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDW-LFRG 949
Query: 633 VFFQPYFMLYGEV 645
+ Y ++G++
Sbjct: 950 AVYHSYLTIFGQI 962
Score = 58.8 bits (136), Expect = 1e-07
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 9/183 (4%)
Query: 741 WITPIAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPP 800
W+T + + +Y + Q+W FQR ++ EY +P PP
Sbjct: 1003 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1062
Query: 801 PLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIK 860
P I+ H+ K V KR + LK LEK + L +E E Y + ++ +
Sbjct: 1063 PFILLNHLQLFIKRVVLKTPAKRHKQ---LKNKLEKNEEAALLSWEIYLKENYLQNRQFQ 1119
Query: 861 LSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAV 920
E+++ + +++V+ + + DL+ ++ S+E RL LE+ QT L
Sbjct: 1120 QKQRPEQKIEDISNKVDAMVDLL-DLD-----PLKRSGSMEQRLASLEEQVAQTARALHW 1173
Query: 921 IHR 923
I R
Sbjct: 1174 IVR 1176
>AY297046-1|AAP44475.1| 1069|Homo sapiens transient receptor
potential cation channel subfamily M member 4 splice
variant protein.
Length = 1069
Score = 134 bits (324), Expect = 2e-30
Identities = 109/384 (28%), Positives = 182/384 (47%), Gaps = 41/384 (10%)
Query: 22 QELDQVILTALFRAQHLTPS----EQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMM 77
+E + ++L AL +A + + ++L LA+ WNRVDIA+SE+F +W L+ ++M
Sbjct: 371 EEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
Query: 78 QALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLP---- 133
AL +DR +FV+LL+ +G+S+ FLT RL +LY+ + PSN+L L D H
Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYS--AAPSNSLIRNLLDQASHSAGTKA 488
Query: 134 ---KGYVYTLH--DIGLVINKLIGGAYRCYY-TRRKFRPIYAKVMNKSVNVHRNSASFTR 187
KG L D+G V+ L+G Y + + P + +S+ + + A+
Sbjct: 489 PALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKAT--- 545
Query: 188 HNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIAC 247
P++ + L P+++LL+WA+L R QMA+ W G +++ +L AC
Sbjct: 546 ------------SPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGAC 593
Query: 248 KLYKXXXXXXXXXXXXXXVYEELRHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNW 307
L + + +FE ++L CYR + +A +LL W
Sbjct: 594 LLLRVMARLEPDAEEAA----RRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW 649
Query: 308 SGQTCLSLAVTANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLCP--LYILRL 365
TCL LA+ A+ RA A Q +L W G + + ++L+ CP +Y +
Sbjct: 650 GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMAS-TTPIWALVLAFFCPPLIYTRLI 708
Query: 366 EFKSKEELQLMPQTEEEHLENESI 389
F+ EE P EE + +S+
Sbjct: 709 TFRKSEE---EPTREELEFDMDSV 729
Score = 75.4 bits (177), Expect = 1e-12
Identities = 30/94 (31%), Positives = 58/94 (61%)
Query: 557 VGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVARQ 616
+GR + C+D + + +R+L+I VNK LGP + ++ KM+K++ +F +++GVA +
Sbjct: 745 LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATE 804
Query: 617 AILHPDKDASWHLIREVFFQPYFMLYGEVFAEQM 650
+L P ++R VF++PY ++G++ E M
Sbjct: 805 GLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDM 838
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/263 (20%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 702 VSHQVFYQPYFMLYGEVFAGDIDPP------CGKEIG---------DRKCVT--GRWITP 744
+ +VFY+PY ++G++ D+D C E G CV+ W+
Sbjct: 817 ILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVV 876
Query: 745 IAMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLII 804
+ + ++ S W QR+ ++ E+ +P L PP I+
Sbjct: 877 LLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV 936
Query: 805 FCHIYAVGKWVTRNVSHKRFQYD--NGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLS 862
H+ + + + R + +++L KE +L +E E + +
Sbjct: 937 ISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKR 996
Query: 863 NSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIH 922
S ER++ T+ +V DL K Q+ ++ E RL+ LE +Q L +
Sbjct: 997 ESDSERLKRTSQKV--------DLALK---QLGHIREYEQRLKVLEREVQQCSRVLGWVA 1045
Query: 923 RFMATHPSLVNRGSTDTLGPPPP 945
+ + +L+ G GPPPP
Sbjct: 1046 EAL-SRSALLPPG-----GPPPP 1062
>DQ139309-1|AAZ73614.1| 1104|Homo sapiens transient receptor
potential subfamily M member 8 protein.
Length = 1104
Score = 113 bits (271), Expect = 6e-24
Identities = 61/211 (28%), Positives = 114/211 (54%), Gaps = 15/211 (7%)
Query: 442 RMRPLRLRKKIY----EFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSI 497
R +P+ KK+ FFT+P F + + YI FLL+F Y +L+ + P PE+
Sbjct: 713 RKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLY 772
Query: 498 CYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDV 557
+ C+++R+ + + + F+ ++WN D + +F+ G+ RL ++
Sbjct: 773 SLVFVLFCDEVRQWYVN---GVNY-FT----DLWNVMDTLGLFYFIAGIVFRLHSSNKSS 824
Query: 558 ---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVA 614
GRVI+C+D I + LR+++I V++ LGP + M+ +M+ ++ +F ++FGVA
Sbjct: 825 LYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVA 884
Query: 615 RQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
RQ IL ++ + R V ++PY ++G+V
Sbjct: 885 RQGILRQNEQRWRWIFRSVIYEPYLAMFGQV 915
Score = 81.4 bits (192), Expect = 2e-14
Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 211 YPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEEL 270
+P L +WA+L + +++ ++W +L A KL K EEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGES-EEL 617
Query: 271 RHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCS 330
+ E+E +A+EL CY D+D A+QLL + W G CL LAV A + +A P
Sbjct: 618 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
Query: 331 QIILADLWMGGLRTRKNTNLKVILSL-LCPL 360
Q L+ W G + +R N K+IL L + PL
Sbjct: 675 QNFLSKQWYGEI-SRDTKNWKIILCLFIIPL 704
Score = 70.9 bits (166), Expect = 3e-11
Identities = 43/112 (38%), Positives = 63/112 (56%), Gaps = 10/112 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV +++E G E+ + I AL++A + + QL L L WN++D+A EI
Sbjct: 391 LTVIKMEEA--GDEI--VSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEI 446
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYN 112
F + W L E M AL DR FV+L LENG+++RKFLT L EL++
Sbjct: 447 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 498
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/201 (23%), Positives = 77/201 (38%), Gaps = 23/201 (11%)
Query: 702 VSHQVFYQPYFMLYGEV---------------FAGDIDPPCGKEIGDRKCVT-GRWITPI 745
+ V Y+PY ++G+V F G+ P E+ + WIT
Sbjct: 899 IFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIP 958
Query: 746 AMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIF 805
+ +Y + QVW FQR+ +V EY + +P P I+F
Sbjct: 959 LVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVF 1018
Query: 806 CHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSI 865
+ Y V K + K ++ + F + ED E L +E E Y + K +N
Sbjct: 1019 AYFYMVVKKCFK-CCCKEKNMESSVCCF-KNEDNETL-AWEGVMKENYLVKINTK-ANDT 1074
Query: 866 EERVRNTTDRVEHITTKMEDL 886
E +R+ R + TK+ DL
Sbjct: 1075 SEEMRH---RFRQLDTKLNDL 1092
>AY328400-1|AAP92167.1| 1104|Homo sapiens transient receptor
potential subfamily M member 8 variant protein.
Length = 1104
Score = 113 bits (271), Expect = 6e-24
Identities = 61/211 (28%), Positives = 114/211 (54%), Gaps = 15/211 (7%)
Query: 442 RMRPLRLRKKIY----EFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSI 497
R +P+ KK+ FFT+P F + + YI FLL+F Y +L+ + P PE+
Sbjct: 713 RKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLY 772
Query: 498 CYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDV 557
+ C+++R+ + + + F+ ++WN D + +F+ G+ RL ++
Sbjct: 773 SLVFVLFCDEVRQWYVN---GVNY-FA----DLWNVMDTLGLFYFIAGIVFRLHSSNKSS 824
Query: 558 ---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVA 614
GRVI+C+D I + LR+++I V++ LGP + M+ +M+ ++ +F ++FGVA
Sbjct: 825 LYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVA 884
Query: 615 RQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
RQ IL ++ + R V ++PY ++G+V
Sbjct: 885 RQGILRQNEQRWRWIFRSVIYEPYLAMFGQV 915
Score = 81.4 bits (192), Expect = 2e-14
Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 211 YPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEEL 270
+P L +WA+L + +++ ++W +L A KL K EEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGES-EEL 617
Query: 271 RHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCS 330
+ E+E +A+EL CY D+D A+QLL + W G CL LAV A + +A P
Sbjct: 618 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
Query: 331 QIILADLWMGGLRTRKNTNLKVILSL-LCPL 360
Q L+ W G + +R N K+IL L + PL
Sbjct: 675 QNFLSKQWYGEI-SRDTKNWKIILCLFIIPL 704
Score = 70.9 bits (166), Expect = 3e-11
Identities = 43/112 (38%), Positives = 63/112 (56%), Gaps = 10/112 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV +++E G E+ + I AL++A + + QL L L WN++D+A EI
Sbjct: 391 LTVIKMEEA--GDEI--VSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEI 446
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYN 112
F + W L E M AL DR FV+L LENG+++RKFLT L EL++
Sbjct: 447 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 498
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/201 (23%), Positives = 77/201 (38%), Gaps = 23/201 (11%)
Query: 702 VSHQVFYQPYFMLYGEV---------------FAGDIDPPCGKEIGDRKCVT-GRWITPI 745
+ V Y+PY ++G+V F G+ P E+ + WIT
Sbjct: 899 IFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIP 958
Query: 746 AMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIF 805
+ +Y + QVW FQR+ +V EY + +P P I+F
Sbjct: 959 LVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVF 1018
Query: 806 CHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSI 865
+ Y V K + K ++ + F + ED E L +E E Y + K +N
Sbjct: 1019 AYFYMVVKKCFK-CCCKEKNMESSVCCF-KNEDNETL-AWEGVMKENYLVKINTK-ANDT 1074
Query: 866 EERVRNTTDRVEHITTKMEDL 886
E +R+ R + TK+ DL
Sbjct: 1075 SEEMRH---RFRQLDTKLNDL 1092
>AY090109-1|AAM10446.1| 1104|Homo sapiens transient receptor
potential cation channel protein protein.
Length = 1104
Score = 113 bits (271), Expect = 6e-24
Identities = 61/211 (28%), Positives = 114/211 (54%), Gaps = 15/211 (7%)
Query: 442 RMRPLRLRKKIY----EFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSI 497
R +P+ KK+ FFT+P F + + YI FLL+F Y +L+ + P PE+
Sbjct: 713 RKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLY 772
Query: 498 CYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDV 557
+ C+++R+ + + + F+ ++WN D + +F+ G+ RL ++
Sbjct: 773 SLVFVLFCDEVRQWYVN---GVNY-FT----DLWNVMDTLGLFYFIAGIVFRLHSSNKSS 824
Query: 558 ---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVA 614
GRVI+C+D I + LR+++I V++ LGP + M+ +M+ ++ +F ++FGVA
Sbjct: 825 LYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVA 884
Query: 615 RQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
RQ IL ++ + R V ++PY ++G+V
Sbjct: 885 RQGILRQNEQRWRWIFRSVIYEPYLAMFGQV 915
Score = 81.4 bits (192), Expect = 2e-14
Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 211 YPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEEL 270
+P L +WA+L + +++ ++W +L A KL K EEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGES-EEL 617
Query: 271 RHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCS 330
+ E+E +A+EL CY D+D A+QLL + W G CL LAV A + +A P
Sbjct: 618 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
Query: 331 QIILADLWMGGLRTRKNTNLKVILSL-LCPL 360
Q L+ W G + +R N K+IL L + PL
Sbjct: 675 QNFLSKQWYGEI-SRDTKNWKIILCLFIIPL 704
Score = 70.9 bits (166), Expect = 3e-11
Identities = 43/112 (38%), Positives = 63/112 (56%), Gaps = 10/112 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV +++E G E+ + I AL++A + + QL L L WN++D+A EI
Sbjct: 391 LTVIKMEEA--GDEI--VSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEI 446
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYN 112
F + W L E M AL DR FV+L LENG+++RKFLT L EL++
Sbjct: 447 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 498
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/201 (23%), Positives = 77/201 (38%), Gaps = 23/201 (11%)
Query: 702 VSHQVFYQPYFMLYGEV---------------FAGDIDPPCGKEIGDRKCVT-GRWITPI 745
+ V Y+PY ++G+V F G+ P E+ + WIT
Sbjct: 899 IFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIP 958
Query: 746 AMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIF 805
+ +Y + QVW FQR+ +V EY + +P P I+F
Sbjct: 959 LVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVF 1018
Query: 806 CHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSI 865
+ Y V K + K ++ + F + ED E L +E E Y + K +N
Sbjct: 1019 AYFYMVVKKCFK-CCCKEKNMESSVCCF-KNEDNETL-AWEGVMKENYLVKINTK-ANDT 1074
Query: 866 EERVRNTTDRVEHITTKMEDL 886
E +R+ R + TK+ DL
Sbjct: 1075 SEEMRH---RFRQLDTKLNDL 1092
>AB061779-1|BAB86335.1| 1095|Homo sapiens LTRPC6 protein.
Length = 1095
Score = 113 bits (271), Expect = 6e-24
Identities = 61/211 (28%), Positives = 114/211 (54%), Gaps = 15/211 (7%)
Query: 442 RMRPLRLRKKIY----EFFTAPITKFWADSIAYILFLLMFTYTVLVKMNPTPSWPEIYSI 497
R +P+ KK+ FFT+P F + + YI FLL+F Y +L+ + P PE+
Sbjct: 704 RKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLY 763
Query: 498 CYILTFLCEKIREIVTSEPVAIRHKFSVWAWNMWNTYDAGFIIFFLVGLTLRLREISRDV 557
+ C+++R+ + + + F+ ++WN D + +F+ G+ RL ++
Sbjct: 764 SLVFVLFCDEVRQWYVN---GVNY-FT----DLWNVMDTLGLFYFIAGIVFRLHSSNKSS 815
Query: 558 ---GRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFXXXXXXXXMSFGVA 614
GRVI+C+D I + LR+++I V++ LGP + M+ +M+ ++ +F ++FGVA
Sbjct: 816 LYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVA 875
Query: 615 RQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
RQ IL ++ + R V ++PY ++G+V
Sbjct: 876 RQGILRQNEQRWRWIFRSVIYEPYLAMFGQV 906
Score = 81.4 bits (192), Expect = 2e-14
Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 211 YPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEEL 270
+P L +WA+L + +++ ++W +L A KL K EEL
Sbjct: 550 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGES-EEL 608
Query: 271 RHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHPCS 330
+ E+E +A+EL CY D+D A+QLL + W G CL LAV A + +A P
Sbjct: 609 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 665
Query: 331 QIILADLWMGGLRTRKNTNLKVILSL-LCPL 360
Q L+ W G + +R N K+IL L + PL
Sbjct: 666 QNFLSKQWYGEI-SRDTKNRKIILCLFIIPL 695
Score = 70.9 bits (166), Expect = 3e-11
Identities = 43/112 (38%), Positives = 63/112 (56%), Gaps = 10/112 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV +++E G E+ + I AL++A + + QL L L WN++D+A EI
Sbjct: 382 LTVIKMEEA--GDEI--VSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEI 437
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYN 112
F + W L E M AL DR FV+L LENG+++RKFLT L EL++
Sbjct: 438 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 489
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/201 (23%), Positives = 77/201 (38%), Gaps = 23/201 (11%)
Query: 702 VSHQVFYQPYFMLYGEV---------------FAGDIDPPCGKEIGDRKCVT-GRWITPI 745
+ V Y+PY ++G+V F G+ P E+ + WIT
Sbjct: 890 IFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIP 949
Query: 746 AMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIF 805
+ +Y + QVW FQR+ +V EY + +P P I+F
Sbjct: 950 LVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVF 1009
Query: 806 CHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSI 865
+ Y V K + K ++ + F + ED E L +E E Y + K +N
Sbjct: 1010 AYFYMVVKKCFK-CCCKEKNMESSVCCF-KNEDNETL-AWEGVMKENYLVKINTK-ANDT 1065
Query: 866 EERVRNTTDRVEHITTKMEDL 886
E +R+ R + TK+ DL
Sbjct: 1066 SEEMRH---RFRQLDTKLNDL 1083
>AK172800-1|BAD18773.1| 746|Homo sapiens 7 (Trpm7). protein.
Length = 746
Score = 106 bits (255), Expect = 5e-22
Identities = 55/151 (36%), Positives = 93/151 (61%), Gaps = 2/151 (1%)
Query: 790 MEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEEC 849
M Y +KPVLPPPLII HI ++ + + K+ + +G KLFL +ED ++L+DFEE+C
Sbjct: 1 MAYHEKPVLPPPLIILSHIVSLFCCICKR--RKKDKTSDGPKLFLTEEDQKKLHDFEEQC 58
Query: 850 VEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLED 909
VE YF E++ K + EER+R T +RVE + +++++ + N +S+QS++ ++ L+D
Sbjct: 59 VEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQD 118
Query: 910 IAEQTMSHLAVIHRFMATHPSLVNRGSTDTL 940
++ T+ L + A+ S V+ T L
Sbjct: 119 LSALTVDTLKTLTAQKASEASKVHNEITREL 149
>BC126342-1|AAI26343.1| 682|Homo sapiens TRPM8 protein protein.
Length = 682
Score = 84.6 bits (200), Expect = 2e-15
Identities = 38/120 (31%), Positives = 71/120 (59%), Gaps = 3/120 (2%)
Query: 529 NMWNTYDAGFIIFFLVGLTLRLREISRDV---GRVIYCVDIIYWYLRILNILGVNKYLGP 585
++WN D + +F+ G+ RL ++ GRVI+C+D I + LR+++I V++ LGP
Sbjct: 374 DLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGP 433
Query: 586 LVTMMGKMVKNMIYFXXXXXXXXMSFGVARQAILHPDKDASWHLIREVFFQPYFMLYGEV 645
+ M+ +M+ ++ +F ++FGVARQ IL ++ + R V ++PY ++G+V
Sbjct: 434 KIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQV 493
Score = 70.9 bits (166), Expect = 3e-11
Identities = 43/112 (38%), Positives = 63/112 (56%), Gaps = 10/112 (8%)
Query: 7 ITVFRIQERAEGGEVQELDQVILTALFRAQHLTPSE------QLSLALTWNRVDIARSEI 60
+TV +++E G E+ + I AL++A + + QL L L WN++D+A EI
Sbjct: 79 LTVIKMEEA--GDEI--VSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEI 134
Query: 61 FVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYN 112
F + W L E M AL DR FV+L LENG+++RKFLT L EL++
Sbjct: 135 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 186
Score = 68.5 bits (160), Expect = 2e-10
Identities = 37/118 (31%), Positives = 56/118 (47%), Gaps = 4/118 (3%)
Query: 211 YPFNELLMWAVLTKRHQMALLMWTHGEESLAKSLIACKLYKXXXXXXXXXXXXXXVYEEL 270
+P L +WA+L + +++ ++W +L A KL K EEL
Sbjct: 247 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGES-EEL 305
Query: 271 RHYGKEFENKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVTANHRALLAHP 328
+ E+E +A+EL CY D+D A+QLL + W G CL LAV A + +A P
Sbjct: 306 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQP 360
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/201 (23%), Positives = 77/201 (38%), Gaps = 23/201 (11%)
Query: 702 VSHQVFYQPYFMLYGEV---------------FAGDIDPPCGKEIGDRKCVT-GRWITPI 745
+ V Y+PY ++G+V F G+ P E+ + WIT
Sbjct: 477 IFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIP 536
Query: 746 AMTVYXXXXXXXXXXXXXXXXXXXXXXXXXXSHQVWMFQRFTVVMEYEQKPVLPPPLIIF 805
+ +Y + QVW FQR+ +V EY + +P P I+F
Sbjct: 537 LVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVF 596
Query: 806 CHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSI 865
+ Y V K + K ++ + F + ED E L +E E Y + K +N
Sbjct: 597 AYFYMVVKKCFK-CCCKEKNMESSVCCF-KNEDNETL-AWEGVMKENYLVKINTK-ANDT 652
Query: 866 EERVRNTTDRVEHITTKMEDL 886
E +R+ R + TK+ DL
Sbjct: 653 SEEMRH---RFRQLDTKLNDL 670
>AB051552-1|BAB21856.1| 608|Homo sapiens KIAA1765 protein protein.
Length = 608
Score = 37.5 bits (83), Expect = 0.33
Identities = 25/82 (30%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 362 ILRLEFKSKEELQLMPQTEEEHLENESIEDDRSTKDPTDAEALIGSGECETRVDQNGKVG 421
I+R E K K E +L E E L + E D D E L+ + C + N G
Sbjct: 96 IIRCE-KCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASG 154
Query: 422 KVGWE-PSYRELPEYHPSEIKR 442
+ GW+ S+R P E++R
Sbjct: 155 EEGWKGDSHRSSPRNPTQELRR 176
>U53225-1|AAA98672.1| 522|Homo sapiens sorting nexin 1 protein.
Length = 522
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>BT006983-1|AAP35629.1| 522|Homo sapiens sorting nexin 1 protein.
Length = 522
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>BC000357-1|AAH00357.1| 522|Homo sapiens sorting nexin 1 protein.
Length = 522
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>AK222793-1|BAD96513.1| 522|Homo sapiens sorting nexin 1 isoform a
variant protein.
Length = 522
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>AK128179-1|BAC87312.1| 557|Homo sapiens protein ( Homo sapiens
cDNA FLJ46302 fis, clone TESTI4036048, highly similar
to Sorting nexin 1. ).
Length = 557
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>AF065484-1|AAC17183.1| 457|Homo sapiens sorting nexin 1A protein.
Length = 457
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 176 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 225
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 226 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 271
>AF065483-1|AAC17182.1| 522|Homo sapiens sorting nexin 1 protein.
Length = 522
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>AB209013-1|BAD92250.1| 432|Homo sapiens sorting nexin 1 isoform a
variant protein.
Length = 432
Score = 36.7 bits (81), Expect = 0.58
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H D ++ FLEKE++ R + G +K+ N
Sbjct: 151 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 200
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 201 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 246
>BC129985-1|AAI29986.1| 348|Homo sapiens KIAA0774 protein.
Length = 348
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 244 KLAEKNI 250
>BC119655-1|AAI19656.1| 258|Homo sapiens KIAA0774 protein protein.
Length = 258
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 34 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 93
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 94 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 153
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 154 KLAEKNI 160
>BC119654-1|AAI19655.1| 348|Homo sapiens KIAA0774 protein.
Length = 348
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 244 KLAEKNI 250
>BC032481-1|AAH32481.1| 348|Homo sapiens KIAA0774 protein.
Length = 348
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 244 KLAEKNI 250
>AL607144-1|CAI40565.1| 1163|Homo sapiens KIAA0774 protein.
Length = 1163
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 939 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 998
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 999 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 1058
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 1059 KLAEKNI 1065
>AL596114-1|CAI39910.1| 1163|Homo sapiens KIAA0774 protein.
Length = 1163
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 939 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 998
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 999 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 1058
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 1059 KLAEKNI 1065
>AL596092-1|CAI40386.1| 1163|Homo sapiens KIAA0774 protein.
Length = 1163
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 939 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 998
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 999 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 1058
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 1059 KLAEKNI 1065
>AL160255-1|CAI41204.1| 1163|Homo sapiens KIAA0774 protein.
Length = 1163
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 939 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 998
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 999 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 1058
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 1059 KLAEKNI 1065
>AB018317-1|BAA34494.2| 1381|Homo sapiens KIAA0774 protein protein.
Length = 1381
Score = 35.9 bits (79), Expect = 1.0
Identities = 26/127 (20%), Positives = 56/127 (44%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 1157 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 1216
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 1217 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 1276
Query: 909 DIAEQTM 915
+AE+ +
Sbjct: 1277 KLAEKNI 1283
>BC011621-1|AAH11621.1| 728|Homo sapiens hook homolog 1
(Drosophila) protein.
Length = 728
Score = 34.3 bits (75), Expect = 3.1
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 9/111 (8%)
Query: 823 RFQYDNG-LKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITT 881
R Q++N L+L E + ER+ + +E+ EQ+ + N +E R + +R+ +
Sbjct: 469 RLQHENKMLRLQQEGSENERIEELQEQL------EQKHRKMNELETEQRLSKERIRELQQ 522
Query: 882 KMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIHRFMATHPSLV 932
++EDL + + Q Q +S KL+ E M L +H + L+
Sbjct: 523 QIEDLQK--SLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI 571
>AL035416-6|CAI22779.1| 728|Homo sapiens hook homolog 1
(Drosophila) protein.
Length = 728
Score = 34.3 bits (75), Expect = 3.1
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 9/111 (8%)
Query: 823 RFQYDNG-LKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITT 881
R Q++N L+L E + ER+ + +E+ EQ+ + N +E R + +R+ +
Sbjct: 469 RLQHENKMLRLQQEGSENERIEELQEQL------EQKHRKMNELETEQRLSKERIRELQQ 522
Query: 882 KMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIHRFMATHPSLV 932
++EDL + + Q Q +S KL+ E M L +H + L+
Sbjct: 523 QIEDLQK--SLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI 571
>AK056459-1|BAB71191.1| 331|Homo sapiens protein ( Homo sapiens cDNA
FLJ31897 fis, clone NT2RP7004080, weakly similar to CELL
SURFACE GLYCOPROTEIN 1 PRECURSOR. ).
Length = 331
Score = 34.3 bits (75), Expect = 3.1
Identities = 24/106 (22%), Positives = 41/106 (38%), Gaps = 3/106 (2%)
Query: 1279 LTVTDRRLPHQRHSLRRSSAVDSR---ELPSPLQPLLGDDACCEVLLPVPRQPSGDTNAS 1335
LTV + P + S+ S A+++ ++P+P LGD+A + P + +
Sbjct: 85 LTVDEPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTR 144
Query: 1336 SDLSLSHMVSENLPPRPSIVLDSSQLPRQRSAEQQQTQPPGPSRPE 1381
D+ H SE + + Q A + PP P E
Sbjct: 145 DDIQFHHFSSEEALQKVKYFVAKEDPSSQEGAHTPEAPPPQPPSSE 190
>AF044923-1|AAC09298.1| 728|Homo sapiens hook1 protein protein.
Length = 728
Score = 34.3 bits (75), Expect = 3.1
Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 9/111 (8%)
Query: 823 RFQYDNG-LKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITT 881
R Q++N L+L E + ER+ + +E+ EQ+ + N +E R + +R+ +
Sbjct: 469 RLQHENKMLRLQQEGSENERIEELQEQL------EQKHRKMNELETEQRLSKERIRELQQ 522
Query: 882 KMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVIHRFMATHPSLV 932
++EDL + + Q Q +S KL+ E M L +H + L+
Sbjct: 523 QIEDLQK--SLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI 571
>BC127816-1|AAI27817.1| 416|Homo sapiens Unknown (protein for
IMAGE:40131779) protein.
Length = 416
Score = 33.9 bits (74), Expect = 4.1
Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 836 KEDMERLYDFEEEC--VEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQ 893
+E E++ + EE+ E REQE ++ EE++ +++ KM++ +K Q
Sbjct: 329 REQKEKIREQEEKIWEQEEKIREQE-EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 387
Query: 894 IQSMQSVEFRLRKLEDIAEQTMSHL 918
+ M E RLR+ E+ ++ HL
Sbjct: 388 EEKMWEQEVRLRQQEEKMQEHQEHL 412
>AK222561-1|BAD96281.1| 522|Homo sapiens sorting nexin 1 isoform a
variant protein.
Length = 522
Score = 33.9 bits (74), Expect = 4.1
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 12/108 (11%)
Query: 810 AVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEIKLSNSIEERV 869
A+ +++ R V+H ++ FLEKE++ R + G +K+ N
Sbjct: 241 ALERYLQRIVNHPTMLQGPDVREFLEKEELPRAVGTQTLSGAGL-----LKMFNK----- 290
Query: 870 RNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSH 917
TD V +T KM + + ++Q ++ E RLRKL + E ++H
Sbjct: 291 --ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNH 336
>AK097517-1|BAC05084.1| 621|Homo sapiens protein ( Homo sapiens
cDNA FLJ40198 fis, clone TESTI2019975, weakly similar to
TRICHOHYALIN. ).
Length = 621
Score = 33.9 bits (74), Expect = 4.1
Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 836 KEDMERLYDFEEEC--VEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQ 893
+E E++ + EE+ E REQE ++ EE++ +++ KM++ +K Q
Sbjct: 534 REQKEKIREQEEKIWEQEEKIREQE-EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 592
Query: 894 IQSMQSVEFRLRKLEDIAEQTMSHL 918
+ M E RLR+ E+ ++ HL
Sbjct: 593 EEKMWEQEVRLRQQEEKMQEHQEHL 617
>BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein.
Length = 1427
Score = 33.5 bits (73), Expect = 5.4
Identities = 16/67 (23%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQI 894
+K++ E++Y E+ ++ Y +QE S+EER+ + +++D ++KAN Q
Sbjct: 1013 QKKETEQMYQIEQSKLKKYIAKQE-----SVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
Query: 895 QSMQSVE 901
++ +++
Sbjct: 1068 KTSSTIQ 1074
>AK125971-1|BAC86369.1| 483|Homo sapiens protein ( Homo sapiens
cDNA FLJ43983 fis, clone TESTI4018881. ).
Length = 483
Score = 33.5 bits (73), Expect = 5.4
Identities = 16/67 (23%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQI 894
+K++ E++Y E+ ++ Y +QE S+EER+ + +++D ++KAN Q
Sbjct: 62 QKKETEQMYQIEQSKLKKYIAKQE-----SVEERLSQLQSENMLLRQQLDDAHKKANSQE 116
Query: 895 QSMQSVE 901
++ +++
Sbjct: 117 KTSSTIQ 123
>AB011137-1|BAA25491.2| 641|Homo sapiens KIAA0565 protein protein.
Length = 641
Score = 33.5 bits (73), Expect = 5.4
Identities = 16/67 (23%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQI 894
+K++ E++Y E+ ++ Y +QE S+EER+ + +++D ++KAN Q
Sbjct: 317 QKKETEQMYQIEQSKLKKYIAKQE-----SVEERLSQLQSENMLLRQQLDDAHKKANSQE 371
Query: 895 QSMQSVE 901
++ +++
Sbjct: 372 KTSSTIQ 378
>BC101678-1|AAI01679.1| 342|Homo sapiens C1orf113 protein protein.
Length = 342
Score = 33.1 bits (72), Expect = 7.2
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 3/106 (2%)
Query: 1279 LTVTDRRLPHQRHSLRRSSAVDSR---ELPSPLQPLLGDDACCEVLLPVPRQPSGDTNAS 1335
LTV P + S+ S A+++ ++P+P LGD+A + P + +
Sbjct: 85 LTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTR 144
Query: 1336 SDLSLSHMVSENLPPRPSIVLDSSQLPRQRSAEQQQTQPPGPSRPE 1381
D+ H SE + + Q A + PP P E
Sbjct: 145 DDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSE 190
>BC101676-1|AAI01677.1| 342|Homo sapiens C1orf113 protein protein.
Length = 342
Score = 33.1 bits (72), Expect = 7.2
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 3/106 (2%)
Query: 1279 LTVTDRRLPHQRHSLRRSSAVDSR---ELPSPLQPLLGDDACCEVLLPVPRQPSGDTNAS 1335
LTV P + S+ S A+++ ++P+P LGD+A + P + +
Sbjct: 85 LTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTR 144
Query: 1336 SDLSLSHMVSENLPPRPSIVLDSSQLPRQRSAEQQQTQPPGPSRPE 1381
D+ H SE + + Q A + PP P E
Sbjct: 145 DDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSE 190
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 302 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 356
>AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein.
Length = 1642
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 302 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 356
>AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein.
Length = 1620
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 271 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 325
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 33.1 bits (72), Expect = 7.2
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 835 EKEDMERLYDFEEECVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQK 889
+KED F +E ++ Y EQ+ K+ NS +E ++ +E + TK+ + +K
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
>X13939-1|CAA32122.1| 328|Homo sapiens laminin B2 protein.
Length = 328
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 150 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 205
>M55210-1|AAA59492.1| 1609|Homo sapiens laminin B2 chain protein.
Length = 1609
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 1431 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 1486
>M27654-1|AAA59489.1| 217|Homo sapiens laminin B2 protein.
Length = 217
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 39 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 94
>J03202-1|AAA59488.1| 1609|Homo sapiens LAMB2 protein.
Length = 1609
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 1431 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 1486
>AL607144-2|CAI40566.1| 348|Homo sapiens KIAA0774 protein.
Length = 348
Score = 32.7 bits (71), Expect = 9.5
Identities = 24/127 (18%), Positives = 55/127 (43%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
Query: 909 DIAEQTM 915
+ ++ +
Sbjct: 244 KLVKKNI 250
>AL596114-2|CAI39912.1| 348|Homo sapiens KIAA0774 protein.
Length = 348
Score = 32.7 bits (71), Expect = 9.5
Identities = 24/127 (18%), Positives = 55/127 (43%)
Query: 789 VMEYEQKPVLPPPLIIFCHIYAVGKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEE 848
++E E + ++ H + V + ++ + K+ +N KL L +D F+ +
Sbjct: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
Query: 849 CVEGYFREQEIKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLE 908
+ R E L + EE++ +H+ M+ L Q + Q + E ++ +LE
Sbjct: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
Query: 909 DIAEQTM 915
+ ++ +
Sbjct: 244 KLVKKNI 250
>AL450304-5|CAI14877.1| 1609|Homo sapiens laminin, gamma 1 (formerly
LAMB2) protein.
Length = 1609
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 1431 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 1486
>AL354953-3|CAH70981.1| 1609|Homo sapiens laminin, gamma 1 (formerly
LAMB2) protein.
Length = 1609
Score = 32.7 bits (71), Expect = 9.5
Identities = 12/56 (21%), Positives = 32/56 (57%)
Query: 860 KLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTM 915
++++++++ +T E ++ DL+ + N ++ +Q E L++ +D A+Q M
Sbjct: 1431 RIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDM 1486
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.136 0.418
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 192,309,511
Number of Sequences: 224733
Number of extensions: 7806330
Number of successful extensions: 23263
Number of sequences better than 10.0: 136
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 22338
Number of HSP's gapped (non-prelim): 532
length of query: 1384
length of database: 73,234,838
effective HSP length: 99
effective length of query: 1285
effective length of database: 50,986,271
effective search space: 65517358235
effective search space used: 65517358235
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 71 (32.7 bits)
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