Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001984-TA|BGIBMGA001984-PA|IPR001130|TatD-related
deoxyribonuclease, IPR012278|Mg-dependent DNase, TatD
(251 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF212250-1|AAK14933.1| 297|Homo sapiens CDA11 protein. 278 2e-74
BC064964-1|AAH64964.1| 297|Homo sapiens TatD DNase domain conta... 277 3e-74
AY071865-1|AAL61823.1| 250|Homo sapiens hepatocarcinoma high ex... 252 1e-66
BC117485-1|AAI17486.1| 274|Homo sapiens TatD DNase domain conta... 73 7e-13
BC113638-1|AAI13639.1| 274|Homo sapiens TatD DNase domain conta... 73 7e-13
BC048115-1|AAH48115.1| 275|Homo sapiens TATDN3 protein protein. 73 7e-13
D86972-1|BAA13208.2| 777|Homo sapiens KIAA0218 protein. 70 7e-12
BC101776-1|AAI01777.1| 761|Homo sapiens TatD DNase domain conta... 70 7e-12
BC101770-1|AAI01771.1| 761|Homo sapiens TatD DNase domain conta... 70 7e-12
BC090935-1|AAH90935.1| 761|Homo sapiens TatD DNase domain conta... 70 7e-12
AL157766-1|CAI13922.2| 4432|Homo sapiens spastic ataxia of Charl... 32 2.2
AF193556-1|AAF31262.1| 3829|Homo sapiens sacsin protein. 32 2.2
>AF212250-1|AAK14933.1| 297|Homo sapiens CDA11 protein.
Length = 297
Score = 278 bits (681), Expect = 2e-74
Identities = 127/252 (50%), Positives = 176/252 (69%), Gaps = 5/252 (1%)
Query: 1 MYKGEYNGSRKHDPDLDVVLERAWTSGINKIIVTGGSLEDSKKAIELSRTDSKLFTTVGC 60
M++G Y G +KH DL V+ RA G+ K ++TGG+L+DSK A+ L++T+ F+TVGC
Sbjct: 17 MFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGC 76
Query: 61 HPTRCSEF-LSNPDDYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEKQL 119
HPTRC EF +NPD YL+ L +L NK KVVAIGECGLD++R FC K+ QLK+FEKQ
Sbjct: 77 HPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQF 136
Query: 120 PLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILELGLSIGIN 179
LS + LP+FLHCR + + ++I+ RNRD+ +GGVVHSFDG+++ +++L L IG N
Sbjct: 137 ELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFN 196
Query: 180 GCSLRSKENIEVASKMPRDKLMIETDCPWCEIKPTHPGYCHVNTKFETVKKTKYSLQRNA 239
GCSL+++ N+EV +P +KLMIETD PWC +K TH G ++ T F T KK +
Sbjct: 197 GCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKK----WESGH 252
Query: 240 QVKGRNEPVNIV 251
+K RNEP +I+
Sbjct: 253 CLKDRNEPCHII 264
>BC064964-1|AAH64964.1| 297|Homo sapiens TatD DNase domain
containing 1 protein.
Length = 297
Score = 277 bits (679), Expect = 3e-74
Identities = 127/252 (50%), Positives = 175/252 (69%), Gaps = 5/252 (1%)
Query: 1 MYKGEYNGSRKHDPDLDVVLERAWTSGINKIIVTGGSLEDSKKAIELSRTDSKLFTTVGC 60
M++G Y G +KH DL V+ RA G+ K ++TGG+L+DSK A+ L++T+ F+TVGC
Sbjct: 17 MFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGC 76
Query: 61 HPTRCSEF-LSNPDDYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEKQL 119
HPTRC EF +NPD YL+ L +L NK KVVAIGECGLD++R FC K+ QLK+FEKQ
Sbjct: 77 HPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQF 136
Query: 120 PLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILELGLSIGIN 179
LS + LP+FLHCR + + ++I RNRD+ +GGVVHSFDG+++ +++L L IG N
Sbjct: 137 ELSEQTKLPMFLHCRNSHAEFLDITKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFN 196
Query: 180 GCSLRSKENIEVASKMPRDKLMIETDCPWCEIKPTHPGYCHVNTKFETVKKTKYSLQRNA 239
GCSL+++ N+EV +P +KLMIETD PWC +K TH G ++ T F T KK +
Sbjct: 197 GCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKK----WESGH 252
Query: 240 QVKGRNEPVNIV 251
+K RNEP +I+
Sbjct: 253 CLKDRNEPCHII 264
>AY071865-1|AAL61823.1| 250|Homo sapiens hepatocarcinoma high
expression protein protein.
Length = 250
Score = 252 bits (616), Expect = 1e-66
Identities = 114/221 (51%), Positives = 158/221 (71%), Gaps = 5/221 (2%)
Query: 32 IVTGGSLEDSKKAIELSRTDSKLFTTVGCHPTRCSEF-LSNPDDYLQGLRDLISGNKDKV 90
++TGG+L+DSK A+ L++T+ F+TVGCHPTRC EF +NPD YL+ L +L NK KV
Sbjct: 1 MITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKV 60
Query: 91 VAIGECGLDYERFHFCEKEVQLKFFEKQLPLSLEYNLPLFLHCRAAADDLIEIISRNRDK 150
VAIGECGLD++R FC K+ QLK+FEKQ LS + LP+FLHCR + + ++I+ RNRD+
Sbjct: 61 VAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDR 120
Query: 151 IIGGVVHSFDGSEQDLQKILELGLSIGINGCSLRSKENIEVASKMPRDKLMIETDCPWCE 210
+GGVVHSFDG+++ +++L L IG NGCSL+++ N+EV +P +KLMIETD PWC
Sbjct: 121 CVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCG 180
Query: 211 IKPTHPGYCHVNTKFETVKKTKYSLQRNAQVKGRNEPVNIV 251
+K TH G ++ T F T KK + +K RNEP +I+
Sbjct: 181 VKSTHAGSKYIRTAFPTKKK----WESGHCLKDRNEPCHII 217
>BC117485-1|AAI17486.1| 274|Homo sapiens TatD DNase domain
containing 3 protein.
Length = 274
Score = 73.3 bits (172), Expect = 7e-13
Identities = 58/206 (28%), Positives = 102/206 (49%), Gaps = 17/206 (8%)
Query: 13 DPDLDVVLERAWTSGINKIIVTGGSLEDSKKAIELS-RTDSKLFTTVGCHPTRCSEFLSN 71
D DLD VLE+A + + ++ + +K ++LS R + + +G HP + L
Sbjct: 21 DRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPV---QGLPP 77
Query: 72 PDDYLQGLRDL------ISGNKDKVVAIGECGLDYE-RFHFC--EKEVQLKFFEKQLPLS 122
D L+DL I KD+++AIGE GLD+ RF +KE Q + +Q+ L+
Sbjct: 78 EDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLA 137
Query: 123 LEYNLPLFLHCRAAADDLIEIIS-RNRDKIIGGVVHSFDGSEQDLQKILELGLSIGINGC 181
NLP+ +H R+A I ++ + +K++ +H+FDG + + G I
Sbjct: 138 KRLNLPVNVHSRSAGRPTINLLQEQGAEKVL---LHAFDGRPSVAMEGVRAGYFFSIPPS 194
Query: 182 SLRSKENIEVASKMPRDKLMIETDCP 207
+RS + ++ ++P + +ETD P
Sbjct: 195 IIRSGQKQKLVKQLPLTSICLETDSP 220
>BC113638-1|AAI13639.1| 274|Homo sapiens TatD DNase domain
containing 3 protein.
Length = 274
Score = 73.3 bits (172), Expect = 7e-13
Identities = 58/206 (28%), Positives = 102/206 (49%), Gaps = 17/206 (8%)
Query: 13 DPDLDVVLERAWTSGINKIIVTGGSLEDSKKAIELS-RTDSKLFTTVGCHPTRCSEFLSN 71
D DLD VLE+A + + ++ + +K ++LS R + + +G HP + L
Sbjct: 21 DRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPV---QGLPP 77
Query: 72 PDDYLQGLRDL------ISGNKDKVVAIGECGLDYE-RFHFC--EKEVQLKFFEKQLPLS 122
D L+DL I KD+++AIGE GLD+ RF +KE Q + +Q+ L+
Sbjct: 78 EDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLA 137
Query: 123 LEYNLPLFLHCRAAADDLIEIIS-RNRDKIIGGVVHSFDGSEQDLQKILELGLSIGINGC 181
NLP+ +H R+A I ++ + +K++ +H+FDG + + G I
Sbjct: 138 KRLNLPVNVHSRSAGRPTINLLQEQGAEKVL---LHAFDGRPSVAMEGVRAGYFFSIPPS 194
Query: 182 SLRSKENIEVASKMPRDKLMIETDCP 207
+RS + ++ ++P + +ETD P
Sbjct: 195 IIRSGQKQKLVKQLPLTSICLETDSP 220
>BC048115-1|AAH48115.1| 275|Homo sapiens TATDN3 protein protein.
Length = 275
Score = 73.3 bits (172), Expect = 7e-13
Identities = 58/206 (28%), Positives = 102/206 (49%), Gaps = 17/206 (8%)
Query: 13 DPDLDVVLERAWTSGINKIIVTGGSLEDSKKAIELS-RTDSKLFTTVGCHPTRCSEFLSN 71
D DLD VLE+A + + ++ + +K ++LS R + + +G HP + L
Sbjct: 22 DRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPV---QGLPP 78
Query: 72 PDDYLQGLRDL------ISGNKDKVVAIGECGLDYE-RFHFC--EKEVQLKFFEKQLPLS 122
D L+DL I KD+++AIGE GLD+ RF +KE Q + +Q+ L+
Sbjct: 79 EDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLA 138
Query: 123 LEYNLPLFLHCRAAADDLIEIIS-RNRDKIIGGVVHSFDGSEQDLQKILELGLSIGINGC 181
NLP+ +H R+A I ++ + +K++ +H+FDG + + G I
Sbjct: 139 KRLNLPVNVHSRSAGRPTINLLQEQGAEKVL---LHAFDGRPSVAMEGVRAGYFFSIPPS 195
Query: 182 SLRSKENIEVASKMPRDKLMIETDCP 207
+RS + ++ ++P + +ETD P
Sbjct: 196 IIRSGQKQKLVKQLPLTSICLETDSP 221
>D86972-1|BAA13208.2| 777|Homo sapiens KIAA0218 protein.
Length = 777
Score = 70.1 bits (164), Expect = 7e-12
Identities = 53/180 (29%), Positives = 84/180 (46%), Gaps = 14/180 (7%)
Query: 59 GCHPTRCSEFLSNPD-DYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEK 117
GCHP + + + + LQ LR K VA GE GLDY Q K FE+
Sbjct: 578 GCHPHFARYYSESQERNLLQALRH------PKAVAFGEMGLDYSYKCTTPVPEQHKVFER 631
Query: 118 QLPLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILEL--GLS 175
QL L++ PL +HCR A +DL+EI+ + H F GS ++ +L+ +S
Sbjct: 632 QLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMS 691
Query: 176 IGINGCSLRSK--ENIEVASKMPRDKLMIETDCPWC---EIKPTHPGYCHVNTKFETVKK 230
+G S E E ++P +++++ETD P+ ++ + Y H TV++
Sbjct: 692 VGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVRE 751
>BC101776-1|AAI01777.1| 761|Homo sapiens TatD DNase domain
containing 2 protein.
Length = 761
Score = 70.1 bits (164), Expect = 7e-12
Identities = 53/180 (29%), Positives = 84/180 (46%), Gaps = 14/180 (7%)
Query: 59 GCHPTRCSEFLSNPD-DYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEK 117
GCHP + + + + LQ LR K VA GE GLDY Q K FE+
Sbjct: 562 GCHPHFARYYSESQERNLLQALRH------PKAVAFGEMGLDYSYKCTTPVPEQHKVFER 615
Query: 118 QLPLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILEL--GLS 175
QL L++ PL +HCR A +DL+EI+ + H F GS ++ +L+ +S
Sbjct: 616 QLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMS 675
Query: 176 IGINGCSLRSK--ENIEVASKMPRDKLMIETDCPWC---EIKPTHPGYCHVNTKFETVKK 230
+G S E E ++P +++++ETD P+ ++ + Y H TV++
Sbjct: 676 VGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVRE 735
>BC101770-1|AAI01771.1| 761|Homo sapiens TatD DNase domain
containing 2 protein.
Length = 761
Score = 70.1 bits (164), Expect = 7e-12
Identities = 53/180 (29%), Positives = 84/180 (46%), Gaps = 14/180 (7%)
Query: 59 GCHPTRCSEFLSNPD-DYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEK 117
GCHP + + + + LQ LR K VA GE GLDY Q K FE+
Sbjct: 562 GCHPHFARYYSESQERNLLQALRH------PKAVAFGEMGLDYSYKCTTPVPEQHKVFER 615
Query: 118 QLPLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILEL--GLS 175
QL L++ PL +HCR A +DL+EI+ + H F GS ++ +L+ +S
Sbjct: 616 QLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMS 675
Query: 176 IGINGCSLRSK--ENIEVASKMPRDKLMIETDCPWC---EIKPTHPGYCHVNTKFETVKK 230
+G S E E ++P +++++ETD P+ ++ + Y H TV++
Sbjct: 676 VGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVRE 735
>BC090935-1|AAH90935.1| 761|Homo sapiens TatD DNase domain
containing 2 protein.
Length = 761
Score = 70.1 bits (164), Expect = 7e-12
Identities = 53/180 (29%), Positives = 84/180 (46%), Gaps = 14/180 (7%)
Query: 59 GCHPTRCSEFLSNPD-DYLQGLRDLISGNKDKVVAIGECGLDYERFHFCEKEVQLKFFEK 117
GCHP + + + + LQ LR K VA GE GLDY Q K FE+
Sbjct: 562 GCHPHFARYYSESQERNLLQALRH------PKAVAFGEMGLDYSYKCTTPVPEQHKVFER 615
Query: 118 QLPLSLEYNLPLFLHCRAAADDLIEIISRNRDKIIGGVVHSFDGSEQDLQKILEL--GLS 175
QL L++ PL +HCR A +DL+EI+ + H F GS ++ +L+ +S
Sbjct: 616 QLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMS 675
Query: 176 IGINGCSLRSK--ENIEVASKMPRDKLMIETDCPWC---EIKPTHPGYCHVNTKFETVKK 230
+G S E E ++P +++++ETD P+ ++ + Y H TV++
Sbjct: 676 VGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVRE 735
>AL157766-1|CAI13922.2| 4432|Homo sapiens spastic ataxia of
Charlevoix-Saguenay (sacsin) protein.
Length = 4432
Score = 31.9 bits (69), Expect = 2.2
Identities = 12/32 (37%), Positives = 16/32 (50%)
Query: 199 KLMIETDCPWCEIKPTHPGYCHVNTKFETVKK 230
K + DCPW ++K T YCH + E K
Sbjct: 2317 KSLCYNDCPWIKVKDTTVKYCHADIPREVAVK 2348
>AF193556-1|AAF31262.1| 3829|Homo sapiens sacsin protein.
Length = 3829
Score = 31.9 bits (69), Expect = 2.2
Identities = 12/32 (37%), Positives = 16/32 (50%)
Query: 199 KLMIETDCPWCEIKPTHPGYCHVNTKFETVKK 230
K + DCPW ++K T YCH + E K
Sbjct: 1714 KSLCYNDCPWIKVKDTTVKYCHADIPREVAVK 1745
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.138 0.413
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 37,098,424
Number of Sequences: 224733
Number of extensions: 1521310
Number of successful extensions: 2627
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2596
Number of HSP's gapped (non-prelim): 14
length of query: 251
length of database: 73,234,838
effective HSP length: 88
effective length of query: 163
effective length of database: 53,458,334
effective search space: 8713708442
effective search space used: 8713708442
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 64 (29.9 bits)
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