Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001969-TA|BGIBMGA001969-PA|IPR000884|Thrombospondin,
type I, IPR006025|Peptidase M, neutral zinc metallopeptidases,
zinc-binding site, IPR001590|Peptidase M12B, ADAM/reprolysin
(754 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC063283-1|AAH63283.1| 1221|Homo sapiens ADAM metallopeptidase w... 182 3e-45
AY327122-1|AAQ94616.1| 1686|Homo sapiens COMPase precursor protein. 176 2e-43
AF140675-1|AAD56358.1| 997|Homo sapiens zinc metalloprotease AD... 176 2e-43
BC061631-1|AAH61631.1| 1686|Homo sapiens ADAM metallopeptidase w... 176 3e-43
AJ311903-1|CAC83612.1| 1081|Homo sapiens ADAMTS18 protein protein. 175 6e-43
AJ315734-1|CAC86015.1| 1072|Homo sapiens metalloprotease disinte... 174 8e-43
AB095949-1|BAC23125.1| 1021|Homo sapiens KIAA2029 protein protein. 174 8e-43
DQ266047-1|ABB70405.1| 570|Homo sapiens ADAMTS16s alternative s... 173 1e-42
AY692424-1|AAW47397.1| 1117|Homo sapiens ADAMTS6 variant 2 protein. 173 2e-42
BC131733-1|AAI31734.1| 1509|Homo sapiens ADAMTS12 protein protein. 167 1e-40
AJ250725-1|CAC20419.1| 1593|Homo sapiens a disintegrin-like and ... 167 1e-40
AB209497-1|BAD92734.1| 527|Homo sapiens a disintegrin and metal... 163 2e-39
AF163762-1|AAG35563.1| 1077|Homo sapiens zinc metalloendopeptida... 157 2e-37
AF488804-1|AAO15766.1| 1911|Homo sapiens a disintegrin-like and ... 145 6e-34
AJ515154-1|CAD56160.2| 1502|Homo sapiens ADAMTS-20 protein protein. 144 8e-34
AJ515153-1|CAD56159.3| 1908|Homo sapiens ADAMTS-20 protein protein. 144 8e-34
AB209515-1|BAD92752.1| 847|Homo sapiens a disintegrin-like and ... 143 2e-33
AP001697-1|BAA95502.1| 967|Homo sapiens metalloprotease with th... 138 7e-32
AF207664-1|AAF23772.1| 967|Homo sapiens matrix metalloprotease ... 138 7e-32
AF170084-1|AAF15317.1| 967|Homo sapiens metalloproteinase with ... 138 7e-32
BC036515-1|AAH36515.1| 967|Homo sapiens ADAM metallopeptidase w... 138 9e-32
AF060152-1|AAD48080.1| 950|Homo sapiens METH1 protein protein. 138 9e-32
AB037767-1|BAA92584.1| 999|Homo sapiens KIAA1346 protein protein. 138 9e-32
BC130578-1|AAI30579.1| 1935|Homo sapiens ADAM metallopeptidase w... 134 1e-30
AF488803-1|AAO15765.1| 1935|Homo sapiens a disintegrin-like and ... 134 1e-30
AB037733-1|BAA92550.1| 1471|Homo sapiens KIAA1312 protein protein. 134 1e-30
DQ422807-1|ABD72606.1| 1427|Homo sapiens ADAM metallopeptidase w... 133 3e-30
AY055376-1|AAL17652.1| 1427|Homo sapiens von Willebrand factor-c... 133 3e-30
AL593848-11|CAI17258.1| 1371|Homo sapiens ADAM metallopeptidase ... 133 3e-30
AL593848-10|CAI17256.1| 1427|Homo sapiens ADAM metallopeptidase ... 133 3e-30
AL158826-24|CAI12850.1| 1427|Homo sapiens ADAM metallopeptidase ... 133 3e-30
AL158826-22|CAI12851.1| 1371|Homo sapiens ADAM metallopeptidase ... 133 3e-30
AJ420810-1|CAD12729.1| 1371|Homo sapiens ADAMTS-13 protein, vari... 133 3e-30
AF414401-1|AAL11095.1| 1427|Homo sapiens ADAMTS13 protein. 133 3e-30
AB069698-1|BAB69487.2| 1427|Homo sapiens von Willebrand factor-c... 133 3e-30
AY692425-1|AAW47398.1| 468|Homo sapiens ADAMTS6 variant 3 protein. 132 6e-30
AF261918-1|AAF89106.1| 1072|Homo sapiens disintegrin metalloprot... 132 6e-30
DQ217943-1|ABB70740.1| 1095|Homo sapiens ADAM metallopeptidase w... 128 5e-29
AJ315735-1|CAC86016.1| 1095|Homo sapiens metalloprotease disinte... 128 5e-29
AK131344-1|BAD18500.1| 502|Homo sapiens protein ( Homo sapiens ... 128 7e-29
AY044847-1|AAL02262.1| 837|Homo sapiens aggrecanase 1 protein. 127 1e-28
AL590714-6|CAH72146.1| 837|Homo sapiens ADAM metallopeptidase w... 127 1e-28
AF148213-1|AAD41494.1| 837|Homo sapiens aggrecanase-1 protein. 127 1e-28
AB014588-1|BAA31663.2| 849|Homo sapiens KIAA0688 protein protein. 127 1e-28
BC132735-1|AAI32736.1| 1205|Homo sapiens ADAMTS3 protein protein. 126 3e-28
BC130287-1|AAI30288.1| 1205|Homo sapiens ADAM metallopeptidase w... 126 3e-28
AJ003125-1|CAA05880.1| 1211|Homo sapiens procollagen I N-protein... 126 3e-28
AB002364-1|BAA20821.1| 1201|Homo sapiens KIAA0366 protein. 126 3e-28
AY358886-1|AAQ89245.1| 837|Homo sapiens ADAMTS4 protein. 124 9e-28
BC063293-1|AAH63293.1| 837|Homo sapiens ADAM metallopeptidase w... 124 2e-27
AJ311904-1|CAC84565.1| 1207|Homo sapiens ADAMTS-19 protein. 122 4e-27
BC109114-1|AAI09115.1| 950|Homo sapiens ADAM metallopeptidase w... 121 1e-26
AJ315733-1|CAC86014.1| 950|Homo sapiens metalloprotease disinte... 121 1e-26
AL358817-5|CAI13857.1| 1226|Homo sapiens ADAM metallopeptidase w... 120 3e-26
AL355344-5|CAI41278.1| 1226|Homo sapiens ADAM metallopeptidase w... 120 3e-26
AF366351-1|AAL79814.1| 1159|Homo sapiens ADAMTS14 protein. 120 3e-26
BC093777-1|AAH93777.1| 930|Homo sapiens ADAM metallopeptidase w... 118 8e-26
BC093775-1|AAH93775.1| 930|Homo sapiens ADAM metallopeptidase w... 118 8e-26
AF142099-1|AAD49577.1| 930|Homo sapiens aggrecanase-2 protein. 118 8e-26
AF060153-1|AAD48081.1| 890|Homo sapiens METH2 protein protein. 117 2e-25
BC089435-1|AAH89435.1| 918|Homo sapiens ADAMTS8 protein protein. 116 3e-25
AL358817-4|CAI13858.1| 1223|Homo sapiens ADAM metallopeptidase w... 116 4e-25
AL355344-4|CAI41277.1| 1223|Homo sapiens ADAM metallopeptidase w... 116 4e-25
AJ345098-1|CAC87943.1| 1223|Homo sapiens metalloprotease-disinte... 116 4e-25
AF358666-1|AAL40229.1| 1223|Homo sapiens a disintegrin-like and ... 116 4e-25
AF140674-1|AAD56357.1| 860|Homo sapiens zinc metalloprotease AD... 114 1e-24
BC113874-1|AAI13875.1| 676|Homo sapiens ADAMTS8 protein protein. 112 5e-24
AL593848-9|CAI17257.1| 1340|Homo sapiens ADAM metallopeptidase w... 107 1e-22
AL158826-23|CAI12852.1| 1340|Homo sapiens ADAM metallopeptidase ... 107 1e-22
AJ305314-1|CAC83682.1| 1340|Homo sapiens ADAMTS-13 protein protein. 107 1e-22
AJ420811-1|CAD12730.1| 344|Homo sapiens ADAMTS-13 protein, trun... 106 3e-22
AF175283-1|AAF25806.1| 246|Homo sapiens zinc metalloendopeptida... 83 4e-15
BC103829-1|AAI03830.1| 276|Homo sapiens ADAMTS13 protein protein. 80 2e-14
BC103828-1|AAI03829.1| 276|Homo sapiens ADAMTS13 protein protein. 80 2e-14
AP001698-1|BAA95504.1| 412|Homo sapiens disintegrin-like and me... 66 4e-10
AK129873-1|BAC85245.1| 226|Homo sapiens protein ( Homo sapiens ... 66 4e-10
D26579-1|BAA05626.1| 824|Homo sapiens transmembrane protein pro... 65 1e-09
BC115404-1|AAI15405.1| 824|Homo sapiens ADAM8 protein protein. 65 1e-09
AY532929-1|AAS54901.1| 90|Homo sapiens von Willebrand factor-c... 56 6e-07
AF141293-1|AAF02493.1| 518|Homo sapiens ADAMTS5 protein protein. 55 8e-07
BC030812-1|AAH30812.1| 339|Homo sapiens ADAMTS4 protein protein. 54 2e-06
AP001697-2|BAA95503.1| 517|Homo sapiens disintegrin-like and me... 54 2e-06
AL590714-7|CAH72147.1| 339|Homo sapiens ADAM metallopeptidase w... 54 2e-06
AL162080-1|CAB82413.1| 550|Homo sapiens hypothetical protein pr... 54 2e-06
BC043207-1|AAH43207.2| 559|Homo sapiens ADAM7 protein protein. 49 5e-05
AF215824-1|AAG43987.1| 754|Homo sapiens a disintegrin and metal... 49 5e-05
Y13786-1|CAC20585.1| 918|Homo sapiens meltrin-beta/ADAM 19 homo... 48 1e-04
DQ995342-1|ABI97387.1| 813|Homo sapiens ADAM metallopeptidase d... 48 1e-04
AY358314-1|AAQ88680.1| 813|Homo sapiens Adam33 protein. 48 1e-04
AL356755-2|CAI23465.1| 813|Homo sapiens ADAM metallopeptidase d... 48 1e-04
AL356755-1|CAM28348.1| 812|Homo sapiens ADAM metallopeptidase d... 48 1e-04
AL109804-2|CAI18840.1| 813|Homo sapiens ADAM metallopeptidase d... 48 1e-04
AL109804-1|CAM26955.1| 812|Homo sapiens ADAM metallopeptidase d... 48 1e-04
AF466288-1|AAM80483.1| 812|Homo sapiens a disintegrin and metal... 48 1e-04
AF466287-1|AAM80482.1| 812|Homo sapiens a disintegrin and metal... 48 1e-04
AF311317-1|AAK07852.1| 918|Homo sapiens disintegrin and metallo... 48 1e-04
AF134707-1|AAF22162.1| 857|Homo sapiens disintegrin and metallo... 48 1e-04
AB055891-1|BAB83092.1| 813|Homo sapiens metalloprotease disinte... 48 1e-04
U41766-1|AAC50403.1| 819|Homo sapiens metalloprotease/disintegr... 47 2e-04
D14665-1|BAA03499.2| 703|Homo sapiens KIAA0021 protein protein. 47 2e-04
BC126406-1|AAI26407.1| 712|Homo sapiens ADAM9 protein protein. 47 2e-04
BC060804-1|AAH60804.1| 737|Homo sapiens ADAM metallopeptidase d... 47 2e-04
AY358878-1|AAQ89237.1| 735|Homo sapiens ADAM-12 protein. 47 2e-04
AL589787-6|CAI40683.1| 738|Homo sapiens ADAM metallopeptidase d... 47 2e-04
AL589787-5|CAI40682.1| 909|Homo sapiens ADAM metallopeptidase d... 47 2e-04
AF495383-1|AAM49575.1| 655|Homo sapiens disintegrin/metalloprot... 47 2e-04
AF023477-1|AAC08703.2| 738|Homo sapiens meltrin-S protein. 47 2e-04
AF023476-1|AAC08702.2| 909|Homo sapiens meltrin-L precursor pro... 47 2e-04
BC109025-1|AAI09026.1| 721|Homo sapiens ADAM21 protein protein. 46 4e-04
BC109024-1|AAI09025.1| 722|Homo sapiens ADAM metallopeptidase d... 46 4e-04
AF158644-1|AAD55255.1| 722|Homo sapiens metalloproteinase-disin... 46 4e-04
AF090327-1|AAC36742.1| 588|Homo sapiens sperm maturation-relate... 46 5e-04
AF029900-1|AAC52042.1| 542|Homo sapiens ADAM 21 protein. 44 0.003
AJ242015-1|CAB42085.1| 775|Homo sapiens eMDC II protein protein. 42 0.011
AF137335-1|AAD25100.1| 540|Homo sapiens metalloprotease disinte... 42 0.011
AF137334-1|AAD25099.1| 775|Homo sapiens metalloprotease disinte... 42 0.011
U46005-1|AAC51112.1| 814|Homo sapiens MDC15 protein. 41 0.014
U41767-1|AAC50404.1| 814|Homo sapiens metargidin precursor prot... 41 0.014
BT009764-1|AAP88766.1| 814|Homo sapiens a disintegrin and metal... 41 0.014
BC014566-1|AAH14566.1| 814|Homo sapiens ADAM metallopeptidase d... 41 0.014
AY576417-1|AAS73000.1| 797|Homo sapiens ADAM15 isoform 8 protein. 41 0.014
AY560601-1|AAS72999.1| 822|Homo sapiens ADAM15 isoform 7b protein. 41 0.014
AY560600-1|AAS72998.1| 821|Homo sapiens ADAM15 isoform 7a protein. 41 0.014
AY560599-1|AAS72997.1| 863|Homo sapiens ADAM15 isoform 6b protein. 41 0.014
AY560598-1|AAS72996.1| 862|Homo sapiens ADAM15 isoform 6a protein. 41 0.014
AY560597-1|AAS72995.1| 838|Homo sapiens ADAM15 isoform 5 protein. 41 0.014
AY560596-1|AAS72994.1| 839|Homo sapiens ADAM15 isoform 4a protein. 41 0.014
AY560595-1|AAS72993.1| 796|Homo sapiens ADAM15 isoform 3a protein. 41 0.014
AY560594-1|AAS72992.1| 814|Homo sapiens ADAM15 isoform 2 protein. 41 0.014
AY560593-1|AAS72991.1| 772|Homo sapiens ADAM15 isoform 1 protein. 41 0.014
AY518542-1|AAR99331.1| 772|Homo sapiens ADAM-15 precursor protein. 41 0.014
AL691442-13|CAI15327.1| 814|Homo sapiens ADAM metallopeptidase ... 41 0.014
AL451085-35|CAI13274.1| 814|Homo sapiens ADAM metallopeptidase ... 41 0.014
AF314227-11|AAS72298.1| 797|Homo sapiens ADAM15 isoform 8 protein. 41 0.014
AF314227-10|AAS48596.1| 821|Homo sapiens ADAM15 isoform 7a prot... 41 0.014
AF314227-9|AAS48597.1| 822|Homo sapiens ADAM15 isoform 7b protein. 41 0.014
AF314227-8|AAS48590.1| 772|Homo sapiens ADAM15 isoform 1 protein. 41 0.014
AF314227-7|AAS48591.1| 796|Homo sapiens ADAM15 isoform 3a protein. 41 0.014
AF314227-6|AAM44189.1| 814|Homo sapiens ADAM15 isoform 2 protein. 41 0.014
AF314227-5|AAS48593.1| 838|Homo sapiens ADAM15 isoform 5 protein. 41 0.014
AF314227-4|AAS48594.1| 862|Homo sapiens ADAM15 isoform 6a protein. 41 0.014
AF314227-3|AAS48592.1| 839|Homo sapiens ADAM15 isoform 4a protein. 41 0.014
AF314227-2|AAS48595.1| 863|Homo sapiens ADAM15 isoform 6b protein. 41 0.014
AB209157-1|BAD92394.1| 859|Homo sapiens ADAM15 isoform 6a varia... 41 0.014
AF171931-1|AAF03779.1| 787|Homo sapiens metallaproteinase-disin... 40 0.032
AF171930-1|AAF03778.1| 766|Homo sapiens metallaproteinase-disin... 40 0.032
AF171929-1|AAF03777.1| 820|Homo sapiens metallaproteinase-disin... 40 0.032
AF134708-1|AAF22163.1| 820|Homo sapiens disintegrin and metallo... 40 0.032
AC105914-1|AAY41055.1| 820|Homo sapiens unknown protein. 40 0.032
DQ202398-1|ABA43715.1| 465|Homo sapiens ADAM21-like protein pro... 40 0.043
BC025378-1|AAH25378.2| 776|Homo sapiens ADAM metallopeptidase d... 38 0.13
AF158643-1|AAD55254.1| 726|Homo sapiens metalloproteinase-disin... 38 0.13
AF029899-1|AAC52041.1| 726|Homo sapiens ADAM 20 protein. 38 0.13
U92649-1|AAC39721.1| 824|Homo sapiens snake venom-like protease... 38 0.17
U86755-1|AAB51586.1| 824|Homo sapiens TNF-alpha converting enzy... 38 0.17
U69612-1|AAB53014.1| 694|Homo sapiens TNF-alpha converting enzy... 38 0.17
U69611-1|AAB51514.1| 824|Homo sapiens TNF-alpha converting enzy... 38 0.17
AC080162-4|AAY14859.1| 543|Homo sapiens unknown protein. 38 0.17
AB095937-1|BAC23113.2| 3051|Homo sapiens KIAA2017 protein protein. 37 0.23
Y13323-1|CAA73764.2| 470|Homo sapiens disintegrin-protease prot... 36 0.40
BC074878-1|AAH74878.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.40
BC074877-1|AAH74877.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.40
BC069582-1|AAH69582.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.40
X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy... 36 0.53
BX641106-1|CAE46049.1| 321|Homo sapiens hypothetical protein pr... 36 0.70
AK131551-1|BAD18685.1| 577|Homo sapiens protein ( Homo sapiens ... 36 0.70
X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (... 34 1.6
M25142-1|AAA60387.1| 389|Homo sapiens myosin heavy chain alpha-... 34 1.6
BC034975-1|AAH34975.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
BC030698-1|AAH30698.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
BC030014-1|AAH30014.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
BC028702-1|AAH28702.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
BC026169-1|AAH26169.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
BC026085-1|AAH26085.1| 787|Homo sapiens ADAM metallopeptidase d... 34 1.6
AY358739-1|AAQ89099.1| 787|Homo sapiens similar to MDC family p... 34 1.6
Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heav... 34 2.1
X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (... 34 2.1
X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac m... 34 2.1
M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain p... 34 2.1
M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain p... 34 2.1
M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain beta-s... 34 2.1
M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myos... 34 2.1
M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myo... 34 2.1
M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac m... 34 2.1
EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7, ... 34 2.1
BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6, ... 34 2.1
BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7, ... 34 2.1
BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7, ... 34 2.1
AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antige... 34 2.1
AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain... 34 2.1
AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypepti... 34 2.1
D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heav... 33 2.8
Z11887-1|CAA77942.1| 267|Homo sapiens PUMP protein. 33 4.9
X07819-1|CAA30678.1| 267|Homo sapiens protein ( Human pump-1 mR... 33 4.9
L22524-1|AAC37543.1| 267|Homo sapiens matrilysin protein. 33 4.9
BC003635-1|AAH03635.1| 267|Homo sapiens matrix metallopeptidase... 33 4.9
AY795972-1|AAV40839.1| 267|Homo sapiens matrix metalloproteinas... 33 4.9
D13636-1|BAA02800.1| 911|Homo sapiens KIAA0011 protein. 32 6.5
BC115737-1|AAI15738.1| 1272|Homo sapiens UPF2 regulator of nonse... 32 6.5
BC114964-1|AAI14965.1| 1272|Homo sapiens UPF2 regulator of nonse... 32 6.5
BC000212-1|AAH00212.1| 585|Homo sapiens GTF3C2 protein protein. 32 6.5
AY013249-1|AAG48509.1| 1272|Homo sapiens hUPF2 protein. 32 6.5
AL645617-2|CAI16756.1| 579|Homo sapiens UPF2 regulator of nonse... 32 6.5
AL645617-1|CAI16755.1| 1272|Homo sapiens UPF2 regulator of nonse... 32 6.5
AL138898-5|CAH73459.1| 579|Homo sapiens UPF2 regulator of nonse... 32 6.5
AL138898-4|CAH73458.1| 1272|Homo sapiens UPF2 regulator of nonse... 32 6.5
AF318574-1|AAG60689.1| 1272|Homo sapiens UPF2 protein. 32 6.5
AF301013-1|AAG33225.1| 1272|Homo sapiens regulator of nonsense t... 32 6.5
AC109828-1|AAY24049.1| 534|Homo sapiens unknown protein. 32 6.5
AB037829-1|BAA92646.1| 1298|Homo sapiens KIAA1408 protein protein. 32 6.5
BT009799-1|AAP88801.1| 911|Homo sapiens general transcription f... 32 8.6
BC020981-1|AAH20981.1| 911|Homo sapiens general transcription f... 32 8.6
AK096191-1|BAC04721.1| 579|Homo sapiens protein ( Homo sapiens ... 32 8.6
>BC063283-1|AAH63283.1| 1221|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 18 protein.
Length = 1221
Score = 182 bits (444), Expect = 3e-45
Identities = 107/299 (35%), Positives = 160/299 (53%), Gaps = 22/299 (7%)
Query: 117 QPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFIL 176
Q + VET V D+ + + K + + ++L ++N V L+ D ++G +N ++
Sbjct: 290 QKGLNVETLVVADKKMVE-------KHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVV 342
Query: 177 KRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNK 236
L +L ++P L H D+ L++FC WQ G N H DHA++LTG D+
Sbjct: 343 VSLILLEQEPGGLLINHHADQSLNSFCQWQSALI--GKNGKRH-DHAILLTGFDICSWKN 399
Query: 237 NGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGC- 295
D+ +G AP++GMC+ SCT+NE + +AHE GHN GM HDG N C
Sbjct: 400 EPCDT---LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG--NPCR 454
Query: 296 DPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPG 353
+MSPTL +G +WS CS+ YL+KFL T Q+ CL+D AGQ + + LPG
Sbjct: 455 KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK--LPG 512
Query: 354 ERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR--ERYTWTSHPALEGTKCGDDMY 410
+ +DAD QC ++G ++ + ++DIC+ L C R R PA EGT CG M+
Sbjct: 513 QIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMW 571
>AY327122-1|AAQ94616.1| 1686|Homo sapiens COMPase precursor protein.
Length = 1686
Score = 176 bits (429), Expect = 2e-43
Identities = 100/304 (32%), Positives = 165/304 (54%), Gaps = 23/304 (7%)
Query: 113 KRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPV 172
+R++ +VET V D + ++ + ++ +VL ++N V L+HDPS+G P+
Sbjct: 235 QRSVSKEKWVETLVVADAKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPI 287
Query: 173 NFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLY 232
+ + RL +L ++ +LK H D L +FC WQ+ N GD PLH D A++LT DL
Sbjct: 288 HITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLC 347
Query: 233 VVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSAD 292
+ +GL+ VAGMC SC++NE + VAHE+GH+ G++HDG +
Sbjct: 348 AAMNR---PCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDG--SG 402
Query: 293 NGCDP---SAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSA 347
N C+P F+MSP L + +TWS+CS+ Y+ +FLD C LD + +D +
Sbjct: 403 NDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLC-LDDPPAKDIIDFPS 461
Query: 348 EGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTS-HPALEGTKCG 406
+ PG +D QC L+YG S + ++++++C L C + A++GT+CG
Sbjct: 462 --VPPGVLYDVSHQCRLQYGAYS--AFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCG 517
Query: 407 DDMY 410
++ +
Sbjct: 518 ENKW 521
>AF140675-1|AAD56358.1| 997|Homo sapiens zinc metalloprotease
ADAMTS7 protein.
Length = 997
Score = 176 bits (429), Expect = 2e-43
Identities = 100/304 (32%), Positives = 165/304 (54%), Gaps = 23/304 (7%)
Query: 113 KRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPV 172
+R++ +VET V D + ++ + ++ +VL ++N V L+HDPS+G P+
Sbjct: 235 QRSVSKEKWVETLVVADAKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPI 287
Query: 173 NFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLY 232
+ + RL +L ++ +LK H D L +FC WQ+ N GD PLH D A++LT DL
Sbjct: 288 HITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLC 347
Query: 233 VVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSAD 292
+ +GL+ VAGMC SC++NE + VAHE+GH+ G++HDG +
Sbjct: 348 AAMNR---PCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDG--SG 402
Query: 293 NGCDP---SAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSA 347
N C+P F+MSP L + +TWS+CS+ Y+ +FLD C LD + +D +
Sbjct: 403 NDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLC-LDDPPAKDIIDFPS 461
Query: 348 EGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTS-HPALEGTKCG 406
+ PG +D QC L+YG S + ++++++C L C + A++GT+CG
Sbjct: 462 --VPPGVLYDVSHQCRLQYGAYS--AFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCG 517
Query: 407 DDMY 410
++ +
Sbjct: 518 ENKW 521
>BC061631-1|AAH61631.1| 1686|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 7 protein.
Length = 1686
Score = 176 bits (428), Expect = 3e-43
Identities = 100/304 (32%), Positives = 165/304 (54%), Gaps = 23/304 (7%)
Query: 113 KRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPV 172
+R++ +VET V D + ++ + ++ +VL ++N V L+HDPS+G P+
Sbjct: 235 QRSVSKEKWVETLVVADAKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPI 287
Query: 173 NFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLY 232
+ + RL +L ++ +LK H D L +FC WQ+ N GD PLH D A++LT DL
Sbjct: 288 HITIVRLVLLEDEEEDLKIMHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLC 347
Query: 233 VVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSAD 292
+ +GL+ VAGMC SC++NE + VAHE+GH+ G++HDG +
Sbjct: 348 AAMNR---PCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDG--SG 402
Query: 293 NGCDP---SAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSA 347
N C+P F+MSP L + +TWS+CS+ Y+ +FLD C LD + +D +
Sbjct: 403 NDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLC-LDDPPAKDIIDFPS 461
Query: 348 EGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTS-HPALEGTKCG 406
+ PG +D QC L+YG S + ++++++C L C + A++GT+CG
Sbjct: 462 --VPPGVLYDVSHQCRLQYGAYS--AFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCG 517
Query: 407 DDMY 410
++ +
Sbjct: 518 ENKW 521
>AJ311903-1|CAC83612.1| 1081|Homo sapiens ADAMTS18 protein protein.
Length = 1081
Score = 175 bits (425), Expect = 6e-43
Identities = 106/299 (35%), Positives = 158/299 (52%), Gaps = 23/299 (7%)
Query: 117 QPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFIL 176
Q + VET V D+ + + K + + ++L ++ V L+ D ++G +N ++
Sbjct: 290 QKGLNVETLVVADKKMVE-------KHGKGNVTTYILTVMK-VSGLFKDGTIGSDINVVV 341
Query: 177 KRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNK 236
L +L ++P L H D+ L++FC WQ G N H DHA++LTG D+
Sbjct: 342 VSLILLEQEPGGLLINHHADQSLNSFCQWQSALI--GKNGKRH-DHAILLTGFDICSWKN 398
Query: 237 NGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGC- 295
D+ +G AP +GMC+ SCT+NE + +AHE GHN GM HDG N C
Sbjct: 399 EPCDT---LGFAPTSGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG--NPCR 453
Query: 296 DPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPG 353
+MSPTL +G +WS CS+ YL+KFL T Q+ CL+D AGQ + + LPG
Sbjct: 454 KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK--LPG 511
Query: 354 ERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR--ERYTWTSHPALEGTKCGDDMY 410
+ +DAD QC ++G ++ + ++DIC+ L C R R PA EGT CG M+
Sbjct: 512 QIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMW 570
>AJ315734-1|CAC86015.1| 1072|Homo sapiens metalloprotease
disintegrin 16 with thrombospondin type I motif protein.
Length = 1072
Score = 174 bits (424), Expect = 8e-43
Identities = 105/294 (35%), Positives = 152/294 (51%), Gaps = 22/294 (7%)
Query: 122 VETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEI 181
VET V VD+ + ++ + +VL ++N V L+ D ++G +N + L +
Sbjct: 292 VETLVVVDKKMMQN-------HGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLIL 344
Query: 182 LHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDS 241
L ++ L H D LS+FC WQ G + H DHA++LTGLD+ D+
Sbjct: 345 LEDEQPGLVISHHADHTLSSFCQWQ--SGLMGKDGTRH-DHAILLTGLDICSWKNEPCDT 401
Query: 242 SQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPS-AF 300
+G AP++GMC+ SCT+NE + +AHE GHN GM HDG N C S
Sbjct: 402 ---LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG--NMCKKSEGN 456
Query: 301 LMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDA 358
+MSPTL +G +WS CS+ YL KFL T Q+ CL D + + + LPGE +DA
Sbjct: 457 IMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGELYDA 514
Query: 359 DQQCMLKYGRGSRHSAAQNLEDICRDLHCQR--ERYTWTSHPALEGTKCGDDMY 410
+ QC ++G ++ +DIC+ L C R + PA EGT CG DM+
Sbjct: 515 NTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMW 568
>AB095949-1|BAC23125.1| 1021|Homo sapiens KIAA2029 protein protein.
Length = 1021
Score = 174 bits (424), Expect = 8e-43
Identities = 105/294 (35%), Positives = 152/294 (51%), Gaps = 22/294 (7%)
Query: 122 VETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEI 181
VET V VD+ + ++ + +VL ++N V L+ D ++G +N + L +
Sbjct: 89 VETLVVVDKKMMQN-------HGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLIL 141
Query: 182 LHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDS 241
L ++ L H D LS+FC WQ G + H DHA++LTGLD+ D+
Sbjct: 142 LEDEQPGLVISHHADHTLSSFCQWQ--SGLMGKDGTRH-DHAILLTGLDICSWKNEPCDT 198
Query: 242 SQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPS-AF 300
+G AP++GMC+ SCT+NE + +AHE GHN GM HDG N C S
Sbjct: 199 ---LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG--NMCKKSEGN 253
Query: 301 LMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDA 358
+MSPTL +G +WS CS+ YL KFL T Q+ CL D + + + LPGE +DA
Sbjct: 254 IMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGELYDA 311
Query: 359 DQQCMLKYGRGSRHSAAQNLEDICRDLHCQR--ERYTWTSHPALEGTKCGDDMY 410
+ QC ++G ++ +DIC+ L C R + PA EGT CG DM+
Sbjct: 312 NTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMW 365
>DQ266047-1|ABB70405.1| 570|Homo sapiens ADAMTS16s alternative
splice form protein.
Length = 570
Score = 173 bits (422), Expect = 1e-42
Identities = 105/293 (35%), Positives = 151/293 (51%), Gaps = 22/293 (7%)
Query: 122 VETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEI 181
VET V VD+ + ++ + +VL ++N V L+ D ++G +N + L +
Sbjct: 292 VETLVVVDKKMMQN-------HGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLIL 344
Query: 182 LHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDS 241
L ++ L H D LS+FC WQ G + H DHA++LTGLD+ D+
Sbjct: 345 LEDEQPGLVISHHADHTLSSFCQWQ--SGLMGKDGTRH-DHAILLTGLDICSWKNEPCDT 401
Query: 242 SQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPS-AF 300
+G AP++GMC+ SCT+NE + +AHE GHN GM HDG N C S
Sbjct: 402 ---LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG--NMCKKSEGN 456
Query: 301 LMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDA 358
+MSPTL +G +WS CS+ YL KFL T Q+ CL D + + + LPGE +DA
Sbjct: 457 IMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGELYDA 514
Query: 359 DQQCMLKYGRGSRHSAAQNLEDICRDLHCQR--ERYTWTSHPALEGTKCGDDM 409
+ QC ++G ++ +DIC+ L C R + PA EGT CG DM
Sbjct: 515 NTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDM 567
>AY692424-1|AAW47397.1| 1117|Homo sapiens ADAMTS6 variant 2 protein.
Length = 1117
Score = 173 bits (421), Expect = 2e-42
Identities = 112/308 (36%), Positives = 160/308 (51%), Gaps = 29/308 (9%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R+KR++ FVET V D+ + + + KD E ++L+++N V LY D SLG
Sbjct: 241 RQKRSVSIERFVETLVVADKMMVGY---HGRKDIEH----YILSVMNIVAKLYRDSSLGN 293
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRL-------ENPPGDNDPLHWDHA 223
VN I+ RL +L ED NL+ H D+ L +FC WQ+ N +N H D+A
Sbjct: 294 VVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNA 353
Query: 224 LILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLG 283
+++T D+ KN +GLA VAGMC SC++NE S + +AHEIGHN G
Sbjct: 354 VLITRYDI-CTYKN--KPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFG 410
Query: 284 MRHDGPSADNGC--DPSAFLMSP--TLGSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNS 339
M HDG G +A LM+ T + +WS CS++Y+ FLD+ + CL N
Sbjct: 411 MNHDGIGNSCGTKGHGAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCL---DNE 467
Query: 340 AGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC--QRERYTWTSH 397
+ D + PG+ +DAD+QC +YG SR ++CR+L C + R S
Sbjct: 468 PPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC---KYGEVCRELWCLSKSNRCVTNSI 524
Query: 398 PALEGTKC 405
PA EGT C
Sbjct: 525 PAAEGTLC 532
>BC131733-1|AAI31734.1| 1509|Homo sapiens ADAMTS12 protein protein.
Length = 1509
Score = 167 bits (406), Expect = 1e-40
Identities = 103/346 (29%), Positives = 181/346 (52%), Gaps = 27/346 (7%)
Query: 70 KRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEK--LATQSIREKRAIQPAIFVETAVF 127
+R + E K LK+ +N++ + + E+ L ++S+ +R+I +VET V
Sbjct: 196 RRQKVPETKEPTCGLKD-SVNISQKQELWREKWERHNLPSRSL-SRRSISKERWVETLVV 253
Query: 128 VDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPA 187
D + ++ + ++L ++N V L+H+PS+G ++ ++ RL +L E+
Sbjct: 254 ADTKMIEY-------HGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQ 306
Query: 188 NLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGL 247
LK H ++ LS+FC WQ+ NP D +P+H D A++LT D+ + +GL
Sbjct: 307 GLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICA---GFNRPCETLGL 363
Query: 248 APVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDP---SAFLMSP 304
+ ++GMC SC +NE + +AHE+GH+ G++HDG +N C+P ++MS
Sbjct: 364 SHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDG--KENDCEPVGRHPYIMSR 421
Query: 305 TL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQC 362
L +TWS+CS+ Y+ +FLD CL D G ++ I PG +D QC
Sbjct: 422 QLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGL---KSKVIAPGVIYDVHHQC 478
Query: 363 MLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTS-HPALEGTKCGD 407
L+YG + + Q +E++C+ L C + + + A +GT+CG+
Sbjct: 479 QLQYGPNA--TFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGE 522
>AJ250725-1|CAC20419.1| 1593|Homo sapiens a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin ty
protein.
Length = 1593
Score = 167 bits (406), Expect = 1e-40
Identities = 103/346 (29%), Positives = 181/346 (52%), Gaps = 27/346 (7%)
Query: 70 KRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEK--LATQSIREKRAIQPAIFVETAVF 127
+R + E K LK+ +N++ + + E+ L ++S+ +R+I +VET V
Sbjct: 196 RRQKVPETKEPTCGLKD-SVNISQKQELWREKWERHNLPSRSL-SRRSISKERWVETLVV 253
Query: 128 VDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPA 187
D + ++ + ++L ++N V L+H+PS+G ++ ++ RL +L E+
Sbjct: 254 ADTKMIEY-------HGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQ 306
Query: 188 NLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGL 247
LK H ++ LS+FC WQ+ NP D +P+H D A++LT D+ + +GL
Sbjct: 307 GLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICA---GFNRPCETLGL 363
Query: 248 APVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDP---SAFLMSP 304
+ ++GMC SC +NE + +AHE+GH+ G++HDG +N C+P ++MS
Sbjct: 364 SHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDG--KENDCEPVGRHPYIMSR 421
Query: 305 TL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQC 362
L +TWS+CS+ Y+ +FLD CL D G ++ I PG +D QC
Sbjct: 422 QLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGL---KSKVIAPGVIYDVHHQC 478
Query: 363 MLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTS-HPALEGTKCGD 407
L+YG + + Q +E++C+ L C + + + A +GT+CG+
Sbjct: 479 QLQYGPNA--TFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGE 522
>AB209497-1|BAD92734.1| 527|Homo sapiens a disintegrin and
metalloprotease with thrombospondin motifs-7
preproprotein va protein.
Length = 527
Score = 163 bits (397), Expect = 2e-39
Identities = 91/260 (35%), Positives = 142/260 (54%), Gaps = 20/260 (7%)
Query: 113 KRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPV 172
+R++ +VET V D + ++ + ++ +VL ++N V L+HDPS+G P+
Sbjct: 200 QRSVSKEKWVETLVVADAKMVEY-------HGQPQVESYVLTIMNMVAGLFHDPSIGNPI 252
Query: 173 NFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLY 232
+ + RL +L ++ +LK H D L +FC WQ+ N GD PLH D A++LT DL
Sbjct: 253 HITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLC 312
Query: 233 VVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSAD 292
+ +GL+ VAGMC SC++NE + VAHE+GH+ G++HDG +
Sbjct: 313 AAMNR---PCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDG--SG 367
Query: 293 NGCDP---SAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSA 347
N C+P F+MSP L + +TWS+CS+ Y+ +FLD C LD + +D +
Sbjct: 368 NDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLC-LDDPPAKDIIDFPS 426
Query: 348 EGILPGERFDADQQCMLKYG 367
+ PG +D QC L+YG
Sbjct: 427 --VPPGVLYDVSHQCRLQYG 444
>AF163762-1|AAG35563.1| 1077|Homo sapiens zinc metalloendopeptidase
protein.
Length = 1077
Score = 157 bits (380), Expect = 2e-37
Identities = 101/306 (33%), Positives = 155/306 (50%), Gaps = 29/306 (9%)
Query: 113 KRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPV 172
KR++ +VET V D+ + + R++ ++VLA++N V L+ D SLG V
Sbjct: 206 KRSVSRERYVETLVVADKMMVAY-------HGRRDVEQYVLAIMNIVAKLFQDSSLGSTV 258
Query: 173 NFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR-LENPPG------DNDPLHWDHALI 225
N ++ RL +L ED L+ H + L +FC WQ+ + N G +N + D A++
Sbjct: 259 NILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVL 318
Query: 226 LTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMR 285
+T D+ + KN + +GLAPV GMC SC+VNE + +AHEIGH GM
Sbjct: 319 ITRYDICIY-KNKPCGT--LGLAPVGGMCERERSCSVNEDIGLPQAFTIAHEIGHTFGMN 375
Query: 286 HDG---PSADNGCDPSAFLMSP-TLGSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAG 341
HDG G DP+ + + T+ + WS C+++Y+ FLD+ CL N
Sbjct: 376 HDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCNRDYITSFLDSGLGLCL---NNRPP 432
Query: 342 QLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC--QRERYTWTSHPA 399
+ D + PG+ +DAD+QC ++G SR ++C +L C + R S PA
Sbjct: 433 RQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC---KYGEVCSELWCLSKSNRCITNSIPA 489
Query: 400 LEGTKC 405
EGT C
Sbjct: 490 AEGTLC 495
>AF488804-1|AAO15766.1| 1911|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motifs 20
protein.
Length = 1911
Score = 145 bits (351), Expect = 6e-34
Identities = 84/271 (30%), Positives = 138/271 (50%), Gaps = 18/271 (6%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L ++L +++ V +Y DPS+G ++ ++ +L ++H + D L NFC+WQ+
Sbjct: 279 LQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQ 338
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
+N D P H D A+++T D+ + K+ +GL+ + +C SC +NE +
Sbjct: 339 TQNDLDDVHPSHHDTAVLITREDIC----SSKEKCNTLGLSYLGTICDPLQSCFINEEKG 394
Query: 268 FESVYVVAHEIGHNLGMRH-DGPSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKF 324
S + +AHE+GH LG++H D P +M+P L +WS CS+ Y+ +F
Sbjct: 395 LISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEF 454
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
LDT CLLD + ++ LPG R+D ++QC L +G GS+ N IC
Sbjct: 455 LDTGYGECLLD---KPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHIN---ICMH 508
Query: 385 LHC----QRERYTWTSH-PALEGTKCGDDMY 410
L C + + +T H P +GT CG M+
Sbjct: 509 LWCTSTEKLHKGCFTQHVPPADGTDCGPGMH 539
>AJ515154-1|CAD56160.2| 1502|Homo sapiens ADAMTS-20 protein protein.
Length = 1502
Score = 144 bits (350), Expect = 8e-34
Identities = 83/271 (30%), Positives = 139/271 (51%), Gaps = 18/271 (6%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L ++L +++ V +Y DPS+G ++ ++ +L ++H + D L NFC+WQ+
Sbjct: 279 LQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQ 338
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
+N D P H D A+++T D+ + K+ ++GL+ + +C SC +NE +
Sbjct: 339 TQNDLDDVHPSHHDTAVLITRYDIC----SSKEKCNMLGLSYLGTICDPLQSCFINEEKG 394
Query: 268 FESVYVVAHEIGHNLGMRH-DGPSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKF 324
S + +AHE+GH LG++H D P +M+P L +WS CS+ Y+ +F
Sbjct: 395 LISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEF 454
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L+T CLLD + ++ LPG R+D ++QC L +G GS+ N IC
Sbjct: 455 LETGYGECLLD---KPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHIN---ICMH 508
Query: 385 LHC----QRERYTWTSH-PALEGTKCGDDMY 410
L C + + +T H P +GT CG M+
Sbjct: 509 LWCTSTEKLHKGCFTQHVPPADGTDCGPGMH 539
>AJ515153-1|CAD56159.3| 1908|Homo sapiens ADAMTS-20 protein protein.
Length = 1908
Score = 144 bits (350), Expect = 8e-34
Identities = 83/271 (30%), Positives = 139/271 (51%), Gaps = 18/271 (6%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L ++L +++ V +Y DPS+G ++ ++ +L ++H + D L NFC+WQ+
Sbjct: 279 LQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQ 338
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
+N D P H D A+++T D+ + K+ ++GL+ + +C SC +NE +
Sbjct: 339 TQNDLDDVHPSHHDTAVLITRYDIC----SSKEKCNMLGLSYLGTICDPLQSCFINEEKG 394
Query: 268 FESVYVVAHEIGHNLGMRH-DGPSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKF 324
S + +AHE+GH LG++H D P +M+P L +WS CS+ Y+ +F
Sbjct: 395 LISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEF 454
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L+T CLLD + ++ LPG R+D ++QC L +G GS+ N IC
Sbjct: 455 LETGYGECLLD---KPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHIN---ICMH 508
Query: 385 LHC----QRERYTWTSH-PALEGTKCGDDMY 410
L C + + +T H P +GT CG M+
Sbjct: 509 LWCTSTEKLHKGCFTQHVPPADGTDCGPGMH 539
>AB209515-1|BAD92752.1| 847|Homo sapiens a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin ty
protein.
Length = 847
Score = 143 bits (347), Expect = 2e-33
Identities = 90/260 (34%), Positives = 132/260 (50%), Gaps = 22/260 (8%)
Query: 159 VQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR-LENPPG---- 213
V L+ D SLG VN ++ RL +L ED L+ H + L +FC WQ+ + N G
Sbjct: 25 VAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNA 84
Query: 214 --DNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESV 271
+N + D A+++T D+ + KN + +GLAPV GMC SC+VNE +
Sbjct: 85 IPENGVANHDTAVLITRYDICIY-KNKPCGT--LGLAPVGGMCERERSCSVNEDIGLATA 141
Query: 272 YVVAHEIGHNLGMRHDG---PSADNGCDPSAFLMSP-TLGSGKITWSQCSKNYLQKFLDT 327
+ +AHEIGH GM HDG G DP+ + + T+ + WS CS++Y+ FLD+
Sbjct: 142 FTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDS 201
Query: 328 VQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC 387
CL N + D + PG+ +DAD+QC ++G SR ++C +L C
Sbjct: 202 GLGLCL---NNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC---KYGEVCSELWC 255
Query: 388 --QRERYTWTSHPALEGTKC 405
+ R S PA EGT C
Sbjct: 256 LSKSNRCITNSIPAAEGTLC 275
>AP001697-1|BAA95502.1| 967|Homo sapiens metalloprotease with
thrombospondin type 1 motifs protein.
Length = 967
Score = 138 bits (334), Expect = 7e-32
Identities = 92/343 (26%), Positives = 157/343 (45%), Gaps = 29/343 (8%)
Query: 75 TENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYK 134
TE++ + T ++ + ++ + + T SIR+KR + +VET + D+ + +
Sbjct: 213 TEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAE 272
Query: 135 HMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHD 194
L ++L + + LY PS+ V+ ++ ++ ++H++ + +
Sbjct: 273 FHGSG--------LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSN 324
Query: 195 IDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMC 254
L NFC WQ+ NPP D D H+D A++ T DL G + +G+A V +C
Sbjct: 325 AALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLC-----GSQTCDTLGMADVGTVC 379
Query: 255 TVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGP---SADNGCDPSAFLMSPTLGS--G 309
+ SC+V E ++ + AHE+GH M HD ++ NG + + +M+ L +
Sbjct: 380 DPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDH 439
Query: 310 KITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRG 369
WS CS + FLD CL+D + QL G LPG +DA++QC +G
Sbjct: 440 SQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQL----PGDLPGTSYDANRQCQFTFGED 495
Query: 370 SRHSAAQNLEDICRDLHCQRER----YTWTSH-PALEGTKCGD 407
S+H + C L C T H P +GT CG+
Sbjct: 496 SKH--CPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGE 536
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 654 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 702
>AF207664-1|AAF23772.1| 967|Homo sapiens matrix metalloprotease
protein.
Length = 967
Score = 138 bits (334), Expect = 7e-32
Identities = 92/343 (26%), Positives = 157/343 (45%), Gaps = 29/343 (8%)
Query: 75 TENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYK 134
TE++ + T ++ + ++ + + T SIR+KR + +VET + D+ + +
Sbjct: 213 TEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAE 272
Query: 135 HMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHD 194
L ++L + + LY PS+ V+ ++ ++ ++H++ + +
Sbjct: 273 FHGSG--------LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSN 324
Query: 195 IDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMC 254
L NFC WQ+ NPP D D H+D A++ T DL G + +G+A V +C
Sbjct: 325 AALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLC-----GSQTCDTLGMADVGTVC 379
Query: 255 TVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGP---SADNGCDPSAFLMSPTLGS--G 309
+ SC+V E ++ + AHE+GH M HD ++ NG + + +M+ L +
Sbjct: 380 DPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDH 439
Query: 310 KITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRG 369
WS CS + FLD CL+D + QL G LPG +DA++QC +G
Sbjct: 440 SQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQL----PGDLPGTSYDANRQCQFTFGED 495
Query: 370 SRHSAAQNLEDICRDLHCQRER----YTWTSH-PALEGTKCGD 407
S+H + C L C T H P +GT CG+
Sbjct: 496 SKH--CPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGE 536
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 654 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 702
>AF170084-1|AAF15317.1| 967|Homo sapiens metalloproteinase with
thrombospondin type 1 motifs ADAMTS1 protein.
Length = 967
Score = 138 bits (334), Expect = 7e-32
Identities = 89/311 (28%), Positives = 145/311 (46%), Gaps = 29/311 (9%)
Query: 107 TQSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDP 166
T SIR+KR + +VET + D+ + + L ++L + + LY P
Sbjct: 245 TGSIRKKRFVSSHRYVETMLVADQSMAEFHGSG--------LKHYLLTLFSVAARLYKHP 296
Query: 167 SLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALIL 226
S+ V+ ++ ++ ++H++ + + L NFC WQ+ NPP D D H+D A++
Sbjct: 297 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILF 356
Query: 227 TGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRH 286
T DL G + +G+A V +C + SC+V E ++ + AHE+GH M H
Sbjct: 357 TRQDLC-----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPH 411
Query: 287 DGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAG 341
D ++ NG + + +M+ L + WS CS + FLD CL+D ++
Sbjct: 412 DDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPHNPI 471
Query: 342 QLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRER----YTWTSH 397
QL G LPG +DA++QC +G S+H + C L C T H
Sbjct: 472 QL----PGDLPGTSYDANRQCQFTFGEDSKH--CPDAASTCSTLWCTGTSGGVLVCQTKH 525
Query: 398 -PALEGTKCGD 407
P +GT CG+
Sbjct: 526 FPWADGTSCGE 536
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 654 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 702
>BC036515-1|AAH36515.1| 967|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 1 protein.
Length = 967
Score = 138 bits (333), Expect = 9e-32
Identities = 89/311 (28%), Positives = 144/311 (46%), Gaps = 29/311 (9%)
Query: 107 TQSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDP 166
T SIR+KR + +VET + D+ + + L ++L + + LY P
Sbjct: 245 TGSIRKKRFVSSHRYVETMLVADQSMAEFHGSG--------LKHYLLTLFSVAARLYKHP 296
Query: 167 SLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALIL 226
S+ V+ ++ ++ ++H++ + + L NFC WQ+ NPP D D H+D A++
Sbjct: 297 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILF 356
Query: 227 TGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRH 286
T DL G + +G+A V +C + SC+V E ++ + AHE+GH M H
Sbjct: 357 TRQDLC-----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPH 411
Query: 287 DGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAG 341
D ++ NG + + +M+ L + WS CS + FLD CL+D +
Sbjct: 412 DDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI 471
Query: 342 QLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRER----YTWTSH 397
QL G LPG +DA++QC +G S+H + C L C T H
Sbjct: 472 QL----PGDLPGTSYDANRQCQFTFGEDSKH--CPDAASTCSTLWCTGTSGGVLVCQTKH 525
Query: 398 -PALEGTKCGD 407
P +GT CG+
Sbjct: 526 FPWADGTSCGE 536
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 654 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSTDSTSVCVQGQCVKAGCD 702
>AF060152-1|AAD48080.1| 950|Homo sapiens METH1 protein protein.
Length = 950
Score = 138 bits (333), Expect = 9e-32
Identities = 89/311 (28%), Positives = 144/311 (46%), Gaps = 29/311 (9%)
Query: 107 TQSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDP 166
T SIR+KR + +VET + D+ + + L ++L + + LY P
Sbjct: 228 TGSIRKKRFVSSHRYVETMLVADQSMAEFHGSG--------LKHYLLTLFSVAARLYKHP 279
Query: 167 SLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALIL 226
S+ V+ ++ ++ ++H++ + + L NFC WQ+ NPP D D H+D A++
Sbjct: 280 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILF 339
Query: 227 TGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRH 286
T DL G + +G+A V +C + SC+V E ++ + AHE+GH M H
Sbjct: 340 TRQDLC-----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPH 394
Query: 287 DGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAG 341
D ++ NG + + +M+ L + WS CS + FLD CL+D +
Sbjct: 395 DDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI 454
Query: 342 QLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRER----YTWTSH 397
QL G LPG +DA++QC +G S+H + C L C T H
Sbjct: 455 QL----PGDLPGTSYDANRQCQFTFGEDSKH--CPDAASTCSTLWCTGTSGGVLVCQTKH 508
Query: 398 -PALEGTKCGD 407
P +GT CG+
Sbjct: 509 FPWADGTSCGE 519
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 637 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 685
>AB037767-1|BAA92584.1| 999|Homo sapiens KIAA1346 protein protein.
Length = 999
Score = 138 bits (333), Expect = 9e-32
Identities = 89/311 (28%), Positives = 144/311 (46%), Gaps = 29/311 (9%)
Query: 107 TQSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDP 166
T SIR+KR + +VET + D+ + + L ++L + + LY P
Sbjct: 277 TGSIRKKRFVSSHRYVETMLVADQSMAEFHGSG--------LKHYLLTLFSVAARLYKHP 328
Query: 167 SLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALIL 226
S+ V+ ++ ++ ++H++ + + L NFC WQ+ NPP D D H+D A++
Sbjct: 329 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILF 388
Query: 227 TGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRH 286
T DL G + +G+A V +C + SC+V E ++ + AHE+GH M H
Sbjct: 389 TRQDLC-----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPH 443
Query: 287 DGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAG 341
D ++ NG + + +M+ L + WS CS + FLD CL+D +
Sbjct: 444 DDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI 503
Query: 342 QLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRER----YTWTSH 397
QL G LPG +DA++QC +G S+H + C L C T H
Sbjct: 504 QL----PGDLPGTSYDANRQCQFTFGEDSKH--CPDAASTCSTLWCTGTSGGVLVCQTKH 557
Query: 398 -PALEGTKCGD 407
P +GT CG+
Sbjct: 558 FPWADGTSCGE 568
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 686 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 734
>BC130578-1|AAI30579.1| 1935|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 9 protein.
Length = 1935
Score = 134 bits (324), Expect = 1e-30
Identities = 120/424 (28%), Positives = 184/424 (43%), Gaps = 51/424 (12%)
Query: 2 GVVKSNDSYYLIHPLPERFHTDD----TKAHIIIKR----RMVDTNNHL---EENVSCVE 50
G +S+D Y I PL +D K HII +R R T H E+ +
Sbjct: 174 GTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHS 233
Query: 51 KDKKNTTLVDQKLWTKHRRKRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSI 110
KDKK T +K + D+ N T + F A+ N+T EK +
Sbjct: 234 KDKKKTRA--RKWGERINLAGDVAALNSGLAT--EAFS---AYGNKT-DNTREKRTHR-- 283
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + FVE V D + + N L ++L +++ V +Y DPS+G
Sbjct: 284 RTKRFLSYPRFVEVLVVADNRMVSYHGEN--------LQHYILTLMSIVASIYKDPSIGN 335
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ L ++H + + L NFC WQ +N PG +H D A++LT D
Sbjct: 336 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGG---IHHDTAVLLTRQD 392
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD--G 288
+ D +GLA + +C SC+++E + + +AHE+GH M HD
Sbjct: 393 IC----RAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNN 448
Query: 289 PSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHS 346
+ G +M+PTL + WS+CS+ Y+ +FLDT CLL+ S +
Sbjct: 449 KCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR---PYP 505
Query: 347 AEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR----ERYTWTSH-PALE 401
LPG ++ ++QC L +G GS+ CR L C + T H P +
Sbjct: 506 LPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWAD 562
Query: 402 GTKC 405
GT+C
Sbjct: 563 GTEC 566
>AF488803-1|AAO15765.1| 1935|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motifs 9B
protein.
Length = 1935
Score = 134 bits (324), Expect = 1e-30
Identities = 120/424 (28%), Positives = 184/424 (43%), Gaps = 51/424 (12%)
Query: 2 GVVKSNDSYYLIHPLPERFHTDD----TKAHIIIKR----RMVDTNNHL---EENVSCVE 50
G +S+D Y I PL +D K HII +R R T H E+ +
Sbjct: 174 GTFRSHDGGYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHS 233
Query: 51 KDKKNTTLVDQKLWTKHRRKRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSI 110
KDKK T +K + D+ N T + F A+ N+T EK +
Sbjct: 234 KDKKKTRA--RKWGERINLAGDVAALNSGLAT--EAFS---AYGNKT-DNTREKRTHR-- 283
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + FVE V D + + N L ++L +++ V +Y DPS+G
Sbjct: 284 RTKRFLSYPRFVEVLVVADNRMVSYHGEN--------LQHYILTLMSIVASIYKDPSIGN 335
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ L ++H + + L NFC WQ +N PG +H D A++LT D
Sbjct: 336 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGG---IHHDTAVLLTRQD 392
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD--G 288
+ D +GLA + +C SC+++E + + +AHE+GH M HD
Sbjct: 393 IC----RAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNN 448
Query: 289 PSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHS 346
+ G +M+PTL + WS+CS+ Y+ +FLDT CLL+ S +
Sbjct: 449 KCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR---PYP 505
Query: 347 AEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR----ERYTWTSH-PALE 401
LPG ++ ++QC L +G GS+ CR L C + T H P +
Sbjct: 506 LPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWAD 562
Query: 402 GTKC 405
GT+C
Sbjct: 563 GTEC 566
>AB037733-1|BAA92550.1| 1471|Homo sapiens KIAA1312 protein protein.
Length = 1471
Score = 134 bits (324), Expect = 1e-30
Identities = 120/424 (28%), Positives = 184/424 (43%), Gaps = 51/424 (12%)
Query: 2 GVVKSNDSYYLIHPLPERFHTDD----TKAHIIIKR----RMVDTNNHL---EENVSCVE 50
G +S+D Y I PL +D K HII +R R T H E+ +
Sbjct: 16 GTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHS 75
Query: 51 KDKKNTTLVDQKLWTKHRRKRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSI 110
KDKK T +K + D+ N T + F A+ N+T EK +
Sbjct: 76 KDKKKTRA--RKWGERINLAGDVAALNSGLAT--EAFS---AYGNKT-DNTREKRTHR-- 125
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + FVE V D + + N L ++L +++ V +Y DPS+G
Sbjct: 126 RTKRFLSYPRFVEVLVVADNRMVSYHGEN--------LQHYILTLMSIVASIYKDPSIGN 177
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ L ++H + + L NFC WQ +N PG +H D A++LT D
Sbjct: 178 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGG---IHHDTAVLLTRQD 234
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD--G 288
+ D +GLA + +C SC+++E + + +AHE+GH M HD
Sbjct: 235 IC----RAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNN 290
Query: 289 PSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHS 346
+ G +M+PTL + WS+CS+ Y+ +FLDT CLL+ S +
Sbjct: 291 KCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR---PYP 347
Query: 347 AEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR----ERYTWTSH-PALE 401
LPG ++ ++QC L +G GS+ CR L C + T H P +
Sbjct: 348 LPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWAD 404
Query: 402 GTKC 405
GT+C
Sbjct: 405 GTEC 408
>DQ422807-1|ABD72606.1| 1427|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AY055376-1|AAL17652.1| 1427|Homo sapiens von Willebrand
factor-cleaving protease precursor protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AL593848-11|CAI17258.1| 1371|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1371
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AL593848-10|CAI17256.1| 1427|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AL158826-24|CAI12850.1| 1427|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AL158826-22|CAI12851.1| 1371|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1371
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AJ420810-1|CAD12729.1| 1371|Homo sapiens ADAMTS-13 protein, variant
2 protein.
Length = 1371
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AF414401-1|AAL11095.1| 1427|Homo sapiens ADAMTS13 protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AB069698-1|BAB69487.2| 1427|Homo sapiens von Willebrand
factor-cleaving protease protein.
Length = 1427
Score = 133 bits (321), Expect = 3e-30
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 23/308 (7%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGN-SAGQLD 344
G + +GC PS +M+ + + + WS CS+ L L ++RC+ D G
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 345 HSAEGILPGERFDADQQCMLKYG-RGSRHSAAQNLEDICRDLHCQRERYTWTS-----HP 398
H + PG + A++QC + +G + + A+ D+C+ L C + +S P
Sbjct: 295 HPPDA-QPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVP 353
Query: 399 ALEGTKCG 406
L+GT+CG
Sbjct: 354 LLDGTECG 361
>AY692425-1|AAW47398.1| 468|Homo sapiens ADAMTS6 variant 3 protein.
Length = 468
Score = 132 bits (318), Expect = 6e-30
Identities = 84/227 (37%), Positives = 121/227 (53%), Gaps = 21/227 (9%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R+KR++ FVET V D+ + + + KD E ++L+++N V LY D SLG
Sbjct: 241 RQKRSVSIERFVETLVVADKMMVGY---HGRKDIEH----YILSVMNIVAKLYRDSSLGN 293
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRL-------ENPPGDNDPLHWDHA 223
VN I+ RL +L ED NL+ H D+ L +FC WQ+ N +N H D+A
Sbjct: 294 VVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNA 353
Query: 224 LILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLG 283
+++T D+ KN +GLA VAGMC SC++NE S + +AHEIGHN G
Sbjct: 354 VLITRYDI-CTYKN--KPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFG 410
Query: 284 MRHDGPSADNGC--DPSAFLMSP--TLGSGKITWSQCSKNYLQKFLD 326
M HDG G +A LM+ T + +WS CS++Y+ FL+
Sbjct: 411 MNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLE 457
>AF261918-1|AAF89106.1| 1072|Homo sapiens disintegrin
metalloproteinase with thrombospondin repeats protein.
Length = 1072
Score = 132 bits (318), Expect = 6e-30
Identities = 119/424 (28%), Positives = 183/424 (43%), Gaps = 51/424 (12%)
Query: 2 GVVKSNDSYYLIHPLPERFHTDD----TKAHIIIKR----RMVDTNNHL---EENVSCVE 50
G +S+D Y I PL +D K HII +R R T H E+ +
Sbjct: 174 GTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHS 233
Query: 51 KDKKNTTLVDQKLWTKHRRKRDIITENKPDNTRLKEFKLNLAHRNRTIGKFIEKLATQSI 110
KDKK T +K + D+ N T + F A+ N+T EK +
Sbjct: 234 KDKKKTRA--RKWGERINLAGDVAALNSGLAT--EAFS---AYGNKT-DNTREKRTHR-- 283
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + FVE V D + + N L ++L +++ V +Y DPS+G
Sbjct: 284 RTKRFLSYPRFVEVLVVADNRMVSYHGEN--------LQHYILTLMSIVASIYKDPSIGN 335
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ L ++H + + L N C WQ +N PG +H D A++LT D
Sbjct: 336 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNLCQWQHSKNSPGG---IHHDTAVLLTRQD 392
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD--G 288
+ D +GLA + +C SC+++E + + +AHE+GH M HD
Sbjct: 393 IC----RAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNN 448
Query: 289 PSADNGCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHS 346
+ G +M+PTL + WS+CS+ Y+ +FLDT CLL+ S +
Sbjct: 449 KCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR---PYP 505
Query: 347 AEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQR----ERYTWTSH-PALE 401
LPG ++ ++QC L +G GS+ CR L C + T H P +
Sbjct: 506 LPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWAD 562
Query: 402 GTKC 405
GT+C
Sbjct: 563 GTEC 566
>DQ217943-1|ABB70740.1| 1095|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif 17 protein.
Length = 1095
Score = 128 bits (310), Expect = 5e-29
Identities = 94/311 (30%), Positives = 149/311 (47%), Gaps = 40/311 (12%)
Query: 122 VETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEI 181
VET V D D+ ++ + RF+L ++N V ++ SLG +N + +L +
Sbjct: 234 VETLVVADADMVQYHGAEAAQ-------RFILTVMNMVYNMFQHQSLGIKINIQVTKLVL 286
Query: 182 LHEDPANLKRPHDIDRFLSNFCTWQRLEN-----------PPGDNDPLHWDHALILTGLD 230
L + PA L H +R L +FC WQ E P G +DP D A+ +T D
Sbjct: 287 LRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTD 346
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPS 290
+ V+K+ + VG+A + G+C+ C + E + +AHE+GHNLGM HD
Sbjct: 347 -FCVHKD--EPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD--D 401
Query: 291 ADNGCDPSAFLMSPTLGSGK----ITWSQCSKNYLQKFLDTVQSRCLL---DHGNSAGQL 343
+ C + +MS G+ ++WS CS++ L+ FL + S CLL +L
Sbjct: 402 DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRL 461
Query: 344 DHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI-CRDLHCQRERYTWTS---HPA 399
H LPG + A++QC + +G + + +N+E + C L C E T P
Sbjct: 462 PHK----LPGMHYSANEQCQILFGMNA--TFCRNMEHLMCAGLWCLVEGDTSCKTKLDPP 515
Query: 400 LEGTKCGDDMY 410
L+GT+CG D +
Sbjct: 516 LDGTECGADKW 526
>AJ315735-1|CAC86016.1| 1095|Homo sapiens metalloprotease
disintegrin 17, with thrombospondin domains protein.
Length = 1095
Score = 128 bits (310), Expect = 5e-29
Identities = 94/311 (30%), Positives = 149/311 (47%), Gaps = 40/311 (12%)
Query: 122 VETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEI 181
VET V D D+ ++ + RF+L ++N V ++ SLG +N + +L +
Sbjct: 234 VETLVVADADMVQYHGAEAAQ-------RFILTVMNMVYNMFQHQSLGIKINIQVTKLVL 286
Query: 182 LHEDPANLKRPHDIDRFLSNFCTWQRLEN-----------PPGDNDPLHWDHALILTGLD 230
L + PA L H +R L +FC WQ E P G +DP D A+ +T D
Sbjct: 287 LRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTD 346
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPS 290
+ V+K+ + VG+A + G+C+ C + E + +AHE+GHNLGM HD
Sbjct: 347 -FCVHKD--EPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD--D 401
Query: 291 ADNGCDPSAFLMSPTLGSGK----ITWSQCSKNYLQKFLDTVQSRCLL---DHGNSAGQL 343
+ C + +MS G+ ++WS CS++ L+ FL + S CLL +L
Sbjct: 402 DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRL 461
Query: 344 DHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI-CRDLHCQRERYTWTS---HPA 399
H LPG + A++QC + +G + + +N+E + C L C E T P
Sbjct: 462 PHK----LPGMHYSANEQCQILFGMNA--TFCRNMEHLMCAGLWCLVEGDTSCKTKLDPP 515
Query: 400 LEGTKCGDDMY 410
L+GT+CG D +
Sbjct: 516 LDGTECGADKW 526
>AK131344-1|BAD18500.1| 502|Homo sapiens protein ( Homo sapiens
cDNA FLJ16363 fis, clone THYMU2031139, weakly similar
to Homo sapiens zinc metalloprotease ADAMTS7 (ADAMTS7)
mRNA. ).
Length = 502
Score = 128 bits (309), Expect = 7e-29
Identities = 88/283 (31%), Positives = 139/283 (49%), Gaps = 33/283 (11%)
Query: 150 RFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLE 209
RF+L ++N V ++ SLG +N + +L +L + PA L H +R L +FC WQ E
Sbjct: 12 RFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEE 71
Query: 210 N-----------PPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTS 258
P G +DP D A+ +T D + V+K+ + VG+A + G+C+
Sbjct: 72 YGGARYLGNNQVPGGKDDPPLVDAAVFVTRTD-FCVHKD--EPCDTVGIAYLGGVCSAKR 128
Query: 259 SCTVNEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSGK----ITWS 314
C + E + +AHE+GHNLGM HD + C + +MS G+ ++WS
Sbjct: 129 KCVLAEDNGLNLAFTIAHELGHNLGMNHD--DDHSSCAGRSHIMSGEWVKGRNPSDLSWS 186
Query: 315 QCSKNYLQKFLDTVQSRCLL---DHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSR 371
CS++ L+ FL + S CLL +L H LPG + A++QC + +G +
Sbjct: 187 SCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHK----LPGMHYSANEQCQILFGMNA- 241
Query: 372 HSAAQNLEDI-CRDLHCQRERYTWTS---HPALEGTKCGDDMY 410
+ +N+E + C L C E T P L+GT+CG D +
Sbjct: 242 -TFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKW 283
>AY044847-1|AAL02262.1| 837|Homo sapiens aggrecanase 1 protein.
Length = 837
Score = 127 bits (307), Expect = 1e-28
Identities = 85/270 (31%), Positives = 123/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P D+DP H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 298 GLNTPEDSDPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 352
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH M HD S + S +M+P + + WS CS ++
Sbjct: 353 LQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 412
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 413 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 466
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 496
Score = 34.3 bits (75), Expect = 1.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + + L E GT C +++S CV G+C+ G D
Sbjct: 615 PQDQCKLTCQAQALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
>AL590714-6|CAH72146.1| 837|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 837
Score = 127 bits (307), Expect = 1e-28
Identities = 85/270 (31%), Positives = 123/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P D+DP H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 298 GLNTPEDSDPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 352
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH M HD S + S +M+P + + WS CS ++
Sbjct: 353 LQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 412
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 413 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 466
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 496
Score = 34.3 bits (75), Expect = 1.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + + L E GT C +++S CV G+C+ G D
Sbjct: 615 PQDQCKLTCQAQALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
>AF148213-1|AAD41494.1| 837|Homo sapiens aggrecanase-1 protein.
Length = 837
Score = 127 bits (307), Expect = 1e-28
Identities = 85/270 (31%), Positives = 123/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P D+DP H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 298 GLNTPEDSDPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 352
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH M HD S + S +M+P + + WS CS ++
Sbjct: 353 LQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 412
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 413 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 466
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 496
Score = 33.5 bits (73), Expect = 2.8
Identities = 16/53 (30%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + L E GT C +++S CV G+C+ G D
Sbjct: 615 PQDQCKLTCQARALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
>AB014588-1|BAA31663.2| 849|Homo sapiens KIAA0688 protein protein.
Length = 849
Score = 127 bits (307), Expect = 1e-28
Identities = 85/270 (31%), Positives = 123/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 250 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 309
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P D+DP H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 310 GLNTPEDSDPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 364
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH M HD S + S +M+P + + WS CS ++
Sbjct: 365 LQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 424
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 425 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 478
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 479 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 508
Score = 33.5 bits (73), Expect = 2.8
Identities = 16/53 (30%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + L E GT C +++S CV G+C+ G D
Sbjct: 627 PQDQCKLTCQARALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 675
>BC132735-1|AAI32736.1| 1205|Homo sapiens ADAMTS3 protein protein.
Length = 1205
Score = 126 bits (304), Expect = 3e-28
Identities = 90/267 (33%), Positives = 127/267 (47%), Gaps = 29/267 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
++L ++N V +YHD SLG +N +L R+ +L + +L + R L N C W +
Sbjct: 280 YLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQ 339
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
N H DHA+ LT D G Q G APV GMC SCT+N F
Sbjct: 340 QRSDLNHSEHHDHAIFLTRQDF------GPAGMQ--GYAPVTGMCHPVRSCTLNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +VVAHE GH LGM HDG N C D +A +M+P + + + WS+CS L+++
Sbjct: 392 SAFVVAHETGHVLGMEHDGQG--NRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGI--LPGERFDADQQCMLKYGRGSRHSAAQNLEDIC 382
+ + CLLD DH + LPG + D+QC +G G + A D C
Sbjct: 450 IHSYD--CLLD-----DPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC 502
Query: 383 RDLHCQRERYTW----TSHPALEGTKC 405
+ L C + P L+GT+C
Sbjct: 503 KQLWCSHPDNPYFCKTKKGPPLDGTEC 529
>BC130287-1|AAI30288.1| 1205|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 3 protein.
Length = 1205
Score = 126 bits (304), Expect = 3e-28
Identities = 90/267 (33%), Positives = 127/267 (47%), Gaps = 29/267 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
++L ++N V +YHD SLG +N +L R+ +L + +L + R L N C W +
Sbjct: 280 YLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQ 339
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
N H DHA+ LT D G Q G APV GMC SCT+N F
Sbjct: 340 QRSDLNHSEHHDHAIFLTRQDF------GPAGMQ--GYAPVTGMCHPVRSCTLNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +VVAHE GH LGM HDG N C D +A +M+P + + + WS+CS L+++
Sbjct: 392 SAFVVAHETGHVLGMEHDGQG--NRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGI--LPGERFDADQQCMLKYGRGSRHSAAQNLEDIC 382
+ + CLLD DH + LPG + D+QC +G G + A D C
Sbjct: 450 IHSYD--CLLD-----DPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC 502
Query: 383 RDLHCQRERYTW----TSHPALEGTKC 405
+ L C + P L+GT+C
Sbjct: 503 KQLWCSHPDNPYFCKTKKGPPLDGTEC 529
>AJ003125-1|CAA05880.1| 1211|Homo sapiens procollagen I N-proteinase
protein.
Length = 1211
Score = 126 bits (304), Expect = 3e-28
Identities = 86/264 (32%), Positives = 124/264 (46%), Gaps = 21/264 (7%)
Query: 150 RFVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRL 208
+++L ++N V +YHD SLG +N +L R+ +L + +L + + L N C W L
Sbjct: 289 KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYL 348
Query: 209 ENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHF 268
+ P + DHA+ LT D G Q G APV GMC SCT+N F
Sbjct: 349 QQKPDTGHDEYHDHAIFLTRQDF------GPSGMQ--GYAPVTGMCHPVRSCTLNHEDGF 400
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-AFLMSPTLGSG--KITWSQCSKNYLQKFL 325
S +VVAHE GH LGM HDG G + +M+P + + + WS+CS+ L ++L
Sbjct: 401 SSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL 460
Query: 326 DTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDL 385
+ CLLD + D A LPG + ++QC +G G A D C+ L
Sbjct: 461 HSYD--CLLDDPFAH---DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQL 515
Query: 386 HCQRERYTW----TSHPALEGTKC 405
C + P L+GT C
Sbjct: 516 WCSHPDNPYFCKTKKGPPLDGTMC 539
>AB002364-1|BAA20821.1| 1201|Homo sapiens KIAA0366 protein.
Length = 1201
Score = 126 bits (304), Expect = 3e-28
Identities = 90/267 (33%), Positives = 127/267 (47%), Gaps = 29/267 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
++L ++N V +YHD SLG +N +L R+ +L + +L + R L N C W +
Sbjct: 276 YLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQ 335
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
N H DHA+ LT D G Q G APV GMC SCT+N F
Sbjct: 336 QRSDLNHSEHHDHAIFLTRQDF------GPAGMQ--GYAPVTGMCHPVRSCTLNHEDGFS 387
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +VVAHE GH LGM HDG N C D +A +M+P + + + WS+CS L+++
Sbjct: 388 SAFVVAHETGHVLGMEHDGQG--NRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRY 445
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGI--LPGERFDADQQCMLKYGRGSRHSAAQNLEDIC 382
+ + CLLD DH + LPG + D+QC +G G + A D C
Sbjct: 446 IHSYD--CLLD-----DPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC 498
Query: 383 RDLHCQRERYTW----TSHPALEGTKC 405
+ L C + P L+GT+C
Sbjct: 499 KQLWCSHPDNPYFCKTKKGPPLDGTEC 525
>AY358886-1|AAQ89245.1| 837|Homo sapiens ADAMTS4 protein.
Length = 837
Score = 124 bits (300), Expect = 9e-28
Identities = 84/270 (31%), Positives = 122/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P D+ P H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 298 GLNTPEDSGPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 352
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH M HD S + S +M+P + + WS CS ++
Sbjct: 353 LQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 412
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 413 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 466
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 496
Score = 33.5 bits (73), Expect = 2.8
Identities = 16/53 (30%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + L E GT C +++S CV G+C+ G D
Sbjct: 615 PQDQCKLTCQARALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
>BC063293-1|AAH63293.1| 837|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 837
Score = 124 bits (298), Expect = 2e-27
Identities = 83/270 (30%), Positives = 123/270 (45%), Gaps = 22/270 (8%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRH 267
N P ++DP H+D A++ T DL G + +G+A V +C SC + E
Sbjct: 298 GLNTPENSDPDHFDTAILFTRQDLC-----GVSTCDTLGMADVGTVCDPARSCAIVEDDG 352
Query: 268 FESVYVVAHEIGHNLGMRHDGP----SADNGCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
+S + AHE+GH + HD S + S +M+P + + WS CS ++
Sbjct: 353 LQSAFTAAHELGHVFNVLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFI 412
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
FLD CLLD + L + PG+ +DAD+QC L +G SRH L
Sbjct: 413 TDFLDNGYGHCLLDKPEAPLHLPVT----FPGKDYDADRQCQLTFGPDSRH--CPQLPPP 466
Query: 382 CRDL----HCQRERYTWTSH-PALEGTKCG 406
C L H T H P +GT CG
Sbjct: 467 CAALWCSGHLNGHAMCQTKHSPWADGTPCG 496
Score = 34.3 bits (75), Expect = 1.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + + L E GT C +++S CV G+C+ G D
Sbjct: 615 PQDQCKLTCQAQALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
>AJ311904-1|CAC84565.1| 1207|Homo sapiens ADAMTS-19 protein.
Length = 1207
Score = 122 bits (295), Expect = 4e-27
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 27/275 (9%)
Query: 150 RFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLE 209
RF+L ++N V L+ SLG VN + +L +LHE P L H ++ L +FC WQ E
Sbjct: 348 RFILTILNMVFNLFQHKSLGVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEE 407
Query: 210 NPPGDNDPLH------W-------DHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTV 256
G + +H W D A+++T D + V+K+ + VG+A ++GMC+
Sbjct: 408 F--GKKNDIHLEMSTNWGEDMTSVDAAILITRKD-FCVHKD--EPCDTVGIAYLSGMCSE 462
Query: 257 TSSCTVNEGRHFESVYVVAHEIGHNLGMRHDG--PSADNGCDPSAFLMSPTLGSGKITWS 314
C + E + +AHE+GHN+G+ HD PS +G + G ++WS
Sbjct: 463 KRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWS 522
Query: 315 QCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSA 374
+CSK L++FL + S CLL N LPG + AD+QC + + G S
Sbjct: 523 RCSKEDLERFLRSKASNCLL-QTNPQSVNSVMVPSKLPGMTYTADEQCQILF--GPLASF 579
Query: 375 AQNLED-ICRDLHC--QRERYTWTS-HPALEGTKC 405
Q ++ IC L C + E+ T P ++GT C
Sbjct: 580 CQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDC 614
Score = 33.5 bits (73), Expect = 2.8
Identities = 47/189 (24%), Positives = 69/189 (36%), Gaps = 17/189 (8%)
Query: 485 CHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAAEWVAASGCHY 544
C E + C + +D + +DC+ A E T+R +S P A EW S C
Sbjct: 593 CKVEGEKECRTKLDPP--MDGTDCDLGKWCKAG-ECTSR--TSAPEHLAGEWSLWSPCSR 647
Query: 545 HCIAPGAGLRLVRAAASPRTSIQLCAPAAAQPHRGCTRRKSPYQ---YATMVCSKYKERV 601
C A G R R + + C Q +R C P + C Y V
Sbjct: 648 TCSA-GISSR-ERKCPGLDSEARDCNGPRKQ-YRICENPPCPAGLPGFRDWQCQAYS--V 702
Query: 602 RRLSGLGMQISPALEDPDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVS 661
R S + A+ D ++PC + C L GT+CG+ C +
Sbjct: 703 RTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMD----GTSCGYQGLDICAN 758
Query: 662 GKCLEFGGD 670
G+C + G D
Sbjct: 759 GRCQKVGCD 767
>BC109114-1|AAI09115.1| 950|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 15 protein.
Length = 950
Score = 121 bits (291), Expect = 1e-26
Identities = 92/310 (29%), Positives = 133/310 (42%), Gaps = 30/310 (9%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
+S R KR + +VET V D + K +L ++L ++ LY PS
Sbjct: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHGA--------DLEHYLLTLLATAARLYRHPS 257
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
+ P+N ++ ++ +L + + K + L NFC WQ+ N D P +WD A++ T
Sbjct: 258 ILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFT 317
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL G + +G+A V MC SC+V E S + AHE+GH M HD
Sbjct: 318 RQDLC-----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHD 372
Query: 288 GPSADN---GCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQ 342
G + +MSPTL WS CS + FLD+ CLLD +
Sbjct: 373 NVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPIS 432
Query: 343 LDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC----QRERYTWTSH- 397
L LPG + QQC L +G GS+ C L C + + T H
Sbjct: 433 LPED----LPGASYTLSQQCELAFGVGSKPCPYM---QYCTKLWCTGKAKGQMVCQTRHF 485
Query: 398 PALEGTKCGD 407
P +GT CG+
Sbjct: 486 PWADGTSCGE 495
>AJ315733-1|CAC86014.1| 950|Homo sapiens metalloprotease
disintegrin 15 with thrombospondin domains protein.
Length = 950
Score = 121 bits (291), Expect = 1e-26
Identities = 92/310 (29%), Positives = 133/310 (42%), Gaps = 30/310 (9%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
+S R KR + +VET V D + K +L ++L ++ LY PS
Sbjct: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHGA--------DLEHYLLTLLATAARLYRHPS 257
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
+ P+N ++ ++ +L + + K + L NFC WQ+ N D P +WD A++ T
Sbjct: 258 ILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFT 317
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL G + +G+A V MC SC+V E S + AHE+GH M HD
Sbjct: 318 RQDLC-----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHD 372
Query: 288 GPSADN---GCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQ 342
G + +MSPTL WS CS + FLD+ CLLD +
Sbjct: 373 NVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPIS 432
Query: 343 LDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC----QRERYTWTSH- 397
L LPG + QQC L +G GS+ C L C + + T H
Sbjct: 433 LPED----LPGASYTLSQQCELAFGVGSKPCPYM---QYCTKLWCTGKAKGQMVCQTRHF 485
Query: 398 PALEGTKCGD 407
P +GT CG+
Sbjct: 486 PWADGTSCGE 495
>AL358817-5|CAI13857.1| 1226|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1226
Score = 120 bits (288), Expect = 3e-26
Identities = 85/265 (32%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G Q G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPSGMQ--GYAPVTGMCHPLRSCALNHEDGFS 394
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 395 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 452
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 453 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 507
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 508 LWCSHPDNPYFCKTKKGPPLDGTEC 532
>AL355344-5|CAI41278.1| 1226|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1226
Score = 120 bits (288), Expect = 3e-26
Identities = 85/265 (32%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G Q G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPSGMQ--GYAPVTGMCHPLRSCALNHEDGFS 394
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 395 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 452
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 453 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 507
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 508 LWCSHPDNPYFCKTKKGPPLDGTEC 532
>AF366351-1|AAL79814.1| 1159|Homo sapiens ADAMTS14 protein.
Length = 1159
Score = 120 bits (288), Expect = 3e-26
Identities = 85/265 (32%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 216 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 275
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G Q G APV GMC SC +N F
Sbjct: 276 QRQDPSHAEHHDHVVFLTRQDF------GPSGMQ--GYAPVTGMCHPLRSCALNHEDGFS 327
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 328 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 385
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 386 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 440
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 441 LWCSHPDNPYFCKTKKGPPLDGTEC 465
>BC093777-1|AAH93777.1| 930|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 5 (aggrecanase-2) protein.
Length = 930
Score = 118 bits (284), Expect = 8e-26
Identities = 86/271 (31%), Positives = 124/271 (45%), Gaps = 22/271 (8%)
Query: 146 RELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTW 205
R L ++L + + LY S+ + + ++ +L + +L+ + L NFC W
Sbjct: 285 RGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKW 344
Query: 206 QRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEG 265
Q N GD+ H+D A++ T DL G S +G+A V +C+ SC V E
Sbjct: 345 QHQHNQLGDDHEEHYDAAILFTREDLC-----GHHSCDTLGMADVGTICSPERSCAVIED 399
Query: 266 RHFESVYVVAHEIGHNLGMRHDGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNY 320
+ + VAHEIGH LG+ HD G LMS L S WS+C+
Sbjct: 400 DGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSAT 459
Query: 321 LQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLED 380
+ +FLD CLLD Q+ E LPG+ +DA QQC L + G +S + D
Sbjct: 460 ITEFLDDGHGNCLLDLPRK--QILGPEE--LPGQTYDATQQCNLTF--GPEYSVCPGM-D 512
Query: 381 ICRDLHC----QRERYTWTSH-PALEGTKCG 406
+C L C Q + T PA+EGT CG
Sbjct: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCG 543
>BC093775-1|AAH93775.1| 930|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 5 (aggrecanase-2) protein.
Length = 930
Score = 118 bits (284), Expect = 8e-26
Identities = 86/271 (31%), Positives = 124/271 (45%), Gaps = 22/271 (8%)
Query: 146 RELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTW 205
R L ++L + + LY S+ + + ++ +L + +L+ + L NFC W
Sbjct: 285 RGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKW 344
Query: 206 QRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEG 265
Q N GD+ H+D A++ T DL G S +G+A V +C+ SC V E
Sbjct: 345 QHQHNQLGDDHEEHYDAAILFTREDLC-----GHHSCDTLGMADVGTICSPERSCAVIED 399
Query: 266 RHFESVYVVAHEIGHNLGMRHDGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNY 320
+ + VAHEIGH LG+ HD G LMS L S WS+C+
Sbjct: 400 DGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSAT 459
Query: 321 LQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLED 380
+ +FLD CLLD Q+ E LPG+ +DA QQC L + G +S + D
Sbjct: 460 ITEFLDDGHGNCLLDLPRK--QILGPEE--LPGQTYDATQQCNLTF--GPEYSVCPGM-D 512
Query: 381 ICRDLHC----QRERYTWTSH-PALEGTKCG 406
+C L C Q + T PA+EGT CG
Sbjct: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCG 543
>AF142099-1|AAD49577.1| 930|Homo sapiens aggrecanase-2 protein.
Length = 930
Score = 118 bits (284), Expect = 8e-26
Identities = 86/271 (31%), Positives = 124/271 (45%), Gaps = 22/271 (8%)
Query: 146 RELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTW 205
R L ++L + + LY S+ + + ++ +L + +L+ + L NFC W
Sbjct: 285 RGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKW 344
Query: 206 QRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEG 265
Q N GD+ H+D A++ T DL G S +G+A V +C+ SC V E
Sbjct: 345 QHQHNQLGDDHEEHYDAAILFTREDLC-----GHHSCDTLGMADVGTICSPERSCAVIED 399
Query: 266 RHFESVYVVAHEIGHNLGMRHDGP---SADNGCDPSAFLMSPTLGS--GKITWSQCSKNY 320
+ + VAHEIGH LG+ HD G LMS L S WS+C+
Sbjct: 400 DGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSAT 459
Query: 321 LQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLED 380
+ +FLD CLLD Q+ E LPG+ +DA QQC L + G +S + D
Sbjct: 460 ITEFLDDGHGNCLLDLPRK--QILGPEE--LPGQTYDATQQCNLTF--GPEYSVCPGM-D 512
Query: 381 ICRDLHC----QRERYTWTSH-PALEGTKCG 406
+C L C Q + T PA+EGT CG
Sbjct: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCG 543
>AF060153-1|AAD48081.1| 890|Homo sapiens METH2 protein protein.
Length = 890
Score = 117 bits (281), Expect = 2e-25
Identities = 85/307 (27%), Positives = 134/307 (43%), Gaps = 25/307 (8%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + A FVET + D M + D + +L +++ +Y PS+
Sbjct: 211 RTKRFVSEARFVETLLVADAS----MAAFYGADLQNH----ILTLMSVAARIYKHPSIKN 262
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ ++ I+ ++ + + L NFC WQR N P D P H+D A++LT +
Sbjct: 263 SINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQN 322
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPS 290
+ G +G+A + +C SC+V E ++ + +AHE+GH L M HD
Sbjct: 323 F--CGQEGL--CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSK 378
Query: 291 ADN---GCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDH 345
G +M+P + + WS CS YL + LD CLLD +A L
Sbjct: 379 PCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPGAALPLPT 438
Query: 346 SAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTSH------PA 399
G + + DQQC +G RH + +D+C L C + H P
Sbjct: 439 GLPGRM--ALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPW 496
Query: 400 LEGTKCG 406
+GT CG
Sbjct: 497 ADGTPCG 503
>BC089435-1|AAH89435.1| 918|Homo sapiens ADAMTS8 protein protein.
Length = 918
Score = 116 bits (279), Expect = 3e-25
Identities = 85/307 (27%), Positives = 134/307 (43%), Gaps = 25/307 (8%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + A FVET + D M + D + +L +++ +Y PS+
Sbjct: 239 RTKRFVSEARFVETLLVADAS----MAAFYGADLQNH----ILTLMSVAARIYKHPSIKN 290
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ ++ I+ ++ + + L NFC WQR N P D P H+D A++LT +
Sbjct: 291 SINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQN 350
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPS 290
+ G +G+A + +C SC+V E ++ + +AHE+GH L M HD
Sbjct: 351 F--CGQEGL--CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSK 406
Query: 291 ADN---GCDPSAFLMSPTLG--SGKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDH 345
G +M+P + + WS CS YL + LD CLLD +A L
Sbjct: 407 PCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPT 466
Query: 346 SAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRERYTWTSH------PA 399
G + + DQQC +G RH + +D+C L C + H P
Sbjct: 467 GLPGRM--ALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPW 524
Query: 400 LEGTKCG 406
+GT CG
Sbjct: 525 ADGTPCG 531
>AL358817-4|CAI13858.1| 1223|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1223
Score = 116 bits (278), Expect = 4e-25
Identities = 84/265 (31%), Positives = 120/265 (45%), Gaps = 28/265 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPS-----GYAPVTGMCHPLRSCALNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 392 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 450 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 504
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 505 LWCSHPDNPYFCKTKKGPPLDGTEC 529
>AL355344-4|CAI41277.1| 1223|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1223
Score = 116 bits (278), Expect = 4e-25
Identities = 84/265 (31%), Positives = 120/265 (45%), Gaps = 28/265 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPS-----GYAPVTGMCHPLRSCALNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 392 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 450 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 504
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 505 LWCSHPDNPYFCKTKKGPPLDGTEC 529
>AJ345098-1|CAC87943.1| 1223|Homo sapiens
metalloprotease-disintegrin protease protein.
Length = 1223
Score = 116 bits (278), Expect = 4e-25
Identities = 84/265 (31%), Positives = 120/265 (45%), Gaps = 28/265 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPS-----GYAPVTGMCHPLRSCALNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 392 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 450 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 504
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 505 LWCSHPDNPYFCKTKKGPPLDGTEC 529
>AF358666-1|AAL40229.1| 1223|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motif 14 prec
protein.
Length = 1223
Score = 116 bits (278), Expect = 4e-25
Identities = 84/265 (31%), Positives = 120/265 (45%), Gaps = 28/265 (10%)
Query: 151 FVLAMINAVQLLYHDPSLGRPVNFILKRLEIL-HEDPANLKRPHDIDRFLSNFCTWQRLE 209
+VL ++N V +YHD SLG +N L RL ++ + +L + R L C W +
Sbjct: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
+ H DH + LT D G G APV GMC SC +N F
Sbjct: 343 QRQDPSHAEHHDHVVFLTRQDF------GPS-----GYAPVTGMCHPLRSCALNHEDGFS 391
Query: 270 SVYVVAHEIGHNLGMRHDGPSADNGC-DPSAF--LMSPTLGSG--KITWSQCSKNYLQKF 324
S +V+AHE GH LGM HDG NGC D ++ +M+P + + + WS+CSK L ++
Sbjct: 392 SAFVIAHETGHVLGMEHDGQG--NGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 449
Query: 325 LDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRD 384
L + CLLD LPG + D+QC +G G + A + C+
Sbjct: 450 LPSYD--CLLDDPFDPAWPQPPE---LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQ 504
Query: 385 LHCQRERYTW----TSHPALEGTKC 405
L C + P L+GT+C
Sbjct: 505 LWCSHPDNPYFCKTKKGPPLDGTEC 529
>AF140674-1|AAD56357.1| 860|Homo sapiens zinc metalloprotease
ADAMTS6 protein.
Length = 860
Score = 114 bits (274), Expect = 1e-24
Identities = 71/185 (38%), Positives = 100/185 (54%), Gaps = 17/185 (9%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R+KR++ FVET V D+ + + + KD E ++L+++N V LY D SLG
Sbjct: 241 RQKRSVSIERFVETLVVADKMMVGY---HGRKDIEH----YILSVMNIVAKLYRDSSLGN 293
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRL-------ENPPGDNDPLHWDHA 223
VN I+ RL +L ED NL+ H D+ L +FC WQ+ N +N H D+A
Sbjct: 294 VVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNA 353
Query: 224 LILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLG 283
+++T D+ KN +GLA VAGMC SC++NE S + +AHEI HN G
Sbjct: 354 VLITRYDI-CTYKN--KPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIVHNFG 410
Query: 284 MRHDG 288
M HDG
Sbjct: 411 MNHDG 415
>BC113874-1|AAI13875.1| 676|Homo sapiens ADAMTS8 protein protein.
Length = 676
Score = 112 bits (269), Expect = 5e-24
Identities = 75/271 (27%), Positives = 121/271 (44%), Gaps = 17/271 (6%)
Query: 147 ELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQ 206
+L +L +++ +Y PS+ +N ++ ++ I+ ++ + + L NFC WQ
Sbjct: 25 DLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQ 84
Query: 207 RLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGR 266
R N P D P H+D A++LT + + G +G+A + +C SC+V E
Sbjct: 85 RRFNQPSDRHPEHYDTAILLTRQNF--CGQEGL--CDTLGVADIGTICDPNKSCSVIEDE 140
Query: 267 HFESVYVVAHEIGHNLGMRHDGPSADN---GCDPSAFLMSPTLG--SGKITWSQCSKNYL 321
++ + +AHE+GH L M HD G +M+P + + WS CS YL
Sbjct: 141 GLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYL 200
Query: 322 QKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDI 381
+ LD CLLD +A L G + + DQQC +G RH + +D+
Sbjct: 201 TELLDGGHGDCLLDAPAAALPLPTGLPGRM--ALYQLDQQCRQIFGPDFRHCPNTSAQDV 258
Query: 382 CRDLHCQRERYTWTSH------PALEGTKCG 406
C L C + H P +GT CG
Sbjct: 259 CAQLWCHTDGAEPLCHTKNGSLPWADGTPCG 289
>AL593848-9|CAI17257.1| 1340|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 13 protein.
Length = 1340
Score = 107 bits (257), Expect = 1e-22
Identities = 74/235 (31%), Positives = 112/235 (47%), Gaps = 16/235 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGNSA 340
G + +GC PS +M+ + + + WS CS+ L L + +C + G A
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLL-SANEQCRVAFGPKA 288
>AL158826-23|CAI12852.1| 1340|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1340
Score = 107 bits (257), Expect = 1e-22
Identities = 74/235 (31%), Positives = 112/235 (47%), Gaps = 16/235 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGNSA 340
G + +GC PS +M+ + + + WS CS+ L L + +C + G A
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLL-SANEQCRVAFGPKA 288
>AJ305314-1|CAC83682.1| 1340|Homo sapiens ADAMTS-13 protein protein.
Length = 1340
Score = 107 bits (257), Expect = 1e-22
Identities = 74/235 (31%), Positives = 112/235 (47%), Gaps = 16/235 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTVQSRCLLDHGNSA 340
G + +GC PS +M+ + + + WS CS+ L L + +C + G A
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLL-SANEQCRVAFGPKA 288
>AJ420811-1|CAD12730.1| 344|Homo sapiens ADAMTS-13 protein,
truncated variant protein.
Length = 344
Score = 106 bits (254), Expect = 3e-22
Identities = 72/223 (32%), Positives = 107/223 (47%), Gaps = 15/223 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH+ G+ HD
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
Query: 288 GPSADNGCDPSAFLMSPTLGSGK--ITWSQCSKNYLQKFLDTV 328
G + +GC PS +M+ + + + WS CS+ L L V
Sbjct: 236 G-APGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLRPV 277
>AF175283-1|AAF25806.1| 246|Homo sapiens zinc metalloendopeptidase
protein.
Length = 246
Score = 83.0 bits (196), Expect = 4e-15
Identities = 50/177 (28%), Positives = 85/177 (48%), Gaps = 12/177 (6%)
Query: 111 REKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGR 170
R KR + A FVET + D M + D + +L +++ +Y PS+
Sbjct: 17 RTKRFVSEARFVETLLVADAS----MAAFYGADLQNH----ILTLMSVAARIYKHPSIKN 68
Query: 171 PVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLD 230
+N ++ ++ I+ ++ + + L NFC WQR N P D P H+D A++LT +
Sbjct: 69 SINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQN 128
Query: 231 LYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHD 287
+ G +G+A + +C SC+V E ++ + +AHE+GH L M HD
Sbjct: 129 F--CGQEGL--CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHD 181
>BC103829-1|AAI03830.1| 276|Homo sapiens ADAMTS13 protein protein.
Length = 276
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/178 (32%), Positives = 83/178 (46%), Gaps = 12/178 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMR 285
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH + R
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHRICAR 233
>BC103828-1|AAI03829.1| 276|Homo sapiens ADAMTS13 protein protein.
Length = 276
Score = 80.2 bits (189), Expect = 2e-14
Identities = 57/178 (32%), Positives = 83/178 (46%), Gaps = 12/178 (6%)
Query: 108 QSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPS 167
Q R++RA + +E V V D+++ +DTER +VL +N L DPS
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQA----HQEDTER----YVLTNLNIGAELLRDPS 119
Query: 168 LGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILT 227
LG L ++ IL E ++ L + C W + NP D DP H D L +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 228 GLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMR 285
DL + + N QV G+ + G C+ T SC + E F+ +AHEIGH + R
Sbjct: 180 RFDLELPDGN----RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHRICAR 233
>AP001698-1|BAA95504.1| 412|Homo sapiens disintegrin-like and
metalloprotease with thrombospondin type 1 motif, 5
protein.
Length = 412
Score = 66.1 bits (154), Expect = 4e-10
Identities = 38/133 (28%), Positives = 62/133 (46%), Gaps = 5/133 (3%)
Query: 146 RELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTW 205
R L ++L + + LY S+ + + ++ +L + +L+ + L NFC W
Sbjct: 285 RGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKW 344
Query: 206 QRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEG 265
Q N GD+ H+D A++ T DL G S +G+A V +C+ SC V E
Sbjct: 345 QHQHNQLGDDHEEHYDAAILFTREDLC-----GHHSCDTLGMADVGTICSPERSCAVIED 399
Query: 266 RHFESVYVVAHEI 278
+ + VAHEI
Sbjct: 400 DGLHAAFTVAHEI 412
>AK129873-1|BAC85245.1| 226|Homo sapiens protein ( Homo sapiens
cDNA FLJ26363 fis, clone HRT05360, highly similar to
ADAM-TS 1 PRECURSOR (EC 3.4.24.-). ).
Length = 226
Score = 66.1 bits (154), Expect = 4e-10
Identities = 35/125 (28%), Positives = 62/125 (49%), Gaps = 8/125 (6%)
Query: 107 TQSIREKRAIQPAIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDP 166
T SIR+KR + +VET + D+ + + L ++L + + LY P
Sbjct: 7 TGSIRKKRFVSSHRYVETMLVADQSMAEFHGSG--------LKHYLLTLFSVAARLYKHP 58
Query: 167 SLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALIL 226
S+ V+ ++ ++ ++H++ + + L NFC WQ+ NPP D D H+D A++
Sbjct: 59 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILF 118
Query: 227 TGLDL 231
T DL
Sbjct: 119 TRQDL 123
>D26579-1|BAA05626.1| 824|Homo sapiens transmembrane protein
protein.
Length = 824
Score = 64.9 bits (151), Expect = 1e-09
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 30/215 (13%)
Query: 159 VQLLYHDPSLGRPVNF--ILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDND 216
++++ H L + +NF +L LEI + P D L N TWQ +
Sbjct: 227 LEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSP-DPSVTLENLLTWQARQRT---RR 282
Query: 217 PLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV--- 273
LH D+ ++TG+D + VG A V+ MC+ SS VN+ V V
Sbjct: 283 HLH-DNVQLITGVDF---------TGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACT 331
Query: 274 VAHEIGHNLGMRHD----GPSADNGCDPSAFLMSPTLGSG-KITWSQCSKNYLQKFLDTV 328
+AHE+GHNLGM HD G + +M+ ++GS +S CS+ YL+ FL+
Sbjct: 332 MAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERP 391
Query: 329 QSRCLLDHGNSAGQLDHSAEGILPGERF-DADQQC 362
QS CL +A L H G + G F + +QC
Sbjct: 392 QSVCLA----NAPDLSHLVGGPVCGNLFVERGEQC 422
>BC115404-1|AAI15405.1| 824|Homo sapiens ADAM8 protein protein.
Length = 824
Score = 64.9 bits (151), Expect = 1e-09
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 30/215 (13%)
Query: 159 VQLLYHDPSLGRPVNF--ILKRLEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDND 216
++++ H L + +NF +L LEI + P D L N TWQ +
Sbjct: 227 LEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSP-DPSVTLENLLTWQARQRT---RR 282
Query: 217 PLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV--- 273
LH D+ ++TG+D + VG A V+ MC+ SS VN+ V V
Sbjct: 283 HLH-DNVQLITGVDF---------TGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACT 331
Query: 274 VAHEIGHNLGMRHD----GPSADNGCDPSAFLMSPTLGSG-KITWSQCSKNYLQKFLDTV 328
+AHE+GHNLGM HD G + +M+ ++GS +S CS+ YL+ FL+
Sbjct: 332 MAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERP 391
Query: 329 QSRCLLDHGNSAGQLDHSAEGILPGERF-DADQQC 362
QS CL +A L H G + G F + +QC
Sbjct: 392 QSVCLA----NAPDLSHLVGGPVCGNLFVERGEQC 422
>AY532929-1|AAS54901.1| 90|Homo sapiens von Willebrand
factor-cleaving protease protein.
Length = 90
Score = 55.6 bits (128), Expect = 6e-07
Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
Query: 199 LSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTS 258
L + C W + NP D DP H D L +T DL + + N QV + + G C+ T
Sbjct: 13 LLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGN----RQVRVVTQLGGACSPTW 68
Query: 259 SCTVNEGRHFESVYVVAHEIGH 280
SC + E F+ +AHEIGH
Sbjct: 69 SCLITEDTGFDLGVTIAHEIGH 90
>AF141293-1|AAF02493.1| 518|Homo sapiens ADAMTS5 protein protein.
Length = 518
Score = 55.2 bits (127), Expect = 8e-07
Identities = 48/138 (34%), Positives = 61/138 (44%), Gaps = 17/138 (12%)
Query: 279 GHNLGMRHDGPSADN---GCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCL 333
GH LG+ HD G LMS L S WS+C+ + +FLD CL
Sbjct: 1 GHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCL 60
Query: 334 LDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC----QR 389
LD Q+ E LPG+ +DA QQC L + G +S D+C L C Q
Sbjct: 61 LDLPRK--QILGPEE--LPGQTYDATQQCNLTF--GPEYSVCPG-XDVCARLWCAVVRQG 113
Query: 390 ERYTWTSH-PALEGTKCG 406
+ T PA+EGT CG
Sbjct: 114 QMVCLTKKLPAVEGTPCG 131
>BC030812-1|AAH30812.1| 339|Homo sapiens ADAMTS4 protein protein.
Length = 339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 27/80 (33%), Positives = 43/80 (53%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILT 227
N P D+DP H+D A++ T
Sbjct: 298 GLNTPEDSDPDHFDTAILFT 317
>AP001697-2|BAA95503.1| 517|Homo sapiens disintegrin-like and
metalloprotease with thrombospondin type 1 motif, 5
protein.
Length = 517
Score = 54.0 bits (124), Expect = 2e-06
Identities = 47/137 (34%), Positives = 61/137 (44%), Gaps = 17/137 (12%)
Query: 280 HNLGMRHDGPSADN---GCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLL 334
H LG+ HD G LMS L S WS+C+ + +FLD CLL
Sbjct: 1 HLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLL 60
Query: 335 DHGNSAGQLDHSAEGILPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHC----QRE 390
D Q+ E LPG+ +DA QQC L + G +S + D+C L C Q +
Sbjct: 61 DLPRK--QILGPEE--LPGQTYDATQQCNLTF--GPEYSVCPGM-DVCARLWCAVVRQGQ 113
Query: 391 RYTWTSH-PALEGTKCG 406
T PA+EGT CG
Sbjct: 114 MVCLTKKLPAVEGTPCG 130
>AL590714-7|CAH72147.1| 339|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 27/80 (33%), Positives = 43/80 (53%)
Query: 148 LVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLKRPHDIDRFLSNFCTWQR 207
L R++L ++ A + PS+ PV+ ++ RL IL + + L +FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 208 LENPPGDNDPLHWDHALILT 227
N P D+DP H+D A++ T
Sbjct: 298 GLNTPEDSDPDHFDTAILFT 317
>AL162080-1|CAB82413.1| 550|Homo sapiens hypothetical protein
protein.
Length = 550
Score = 54.0 bits (124), Expect = 2e-06
Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 13/122 (10%)
Query: 293 NGCDPSAFLMSPTLGS--GKITWSQCSKNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGI 350
NG + + +M+ L + WS CS + FLD CL+D + QL G
Sbjct: 4 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLP----GD 59
Query: 351 LPGERFDADQQCMLKYGRGSRHSAAQNLEDICRDLHCQRER----YTWTSH-PALEGTKC 405
LPG +DA++QC +G S+H + C L C T H P +GT C
Sbjct: 60 LPGTSYDANRQCQFTFGEDSKH--CPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSC 117
Query: 406 GD 407
G+
Sbjct: 118 GE 119
Score = 31.9 bits (69), Expect = 8.6
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 618 PDRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGD 670
P C++ CQ + + + F L + GT C ++ S CV G+C++ G D
Sbjct: 237 PKDRCKLICQAKGIGYFFVL----QPKVVDGTPCSPDSTSVCVQGQCVKAGCD 285
>BC043207-1|AAH43207.2| 559|Homo sapiens ADAM7 protein protein.
Length = 559
Score = 49.2 bits (112), Expect = 5e-05
Identities = 49/189 (25%), Positives = 87/189 (46%), Gaps = 27/189 (14%)
Query: 152 VLAMINAVQLLYHDPSLGRPVNFILKRLEI-LHEDPANLKRPHDIDRFLSNFCTWQ-RLE 209
+ M+N V ++Y + ++ L +EI HED L +I+ L F WQ ++
Sbjct: 41 IWGMVNFVNMIYKTLN----IHVTLVGIEIWTHEDKIELYS--NIETTLLRFSFWQEKIL 94
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
D +DH ++L+G LY S V G++ GMC S ++ + +
Sbjct: 95 KTRKD-----FDHVVLLSGKWLY---------SHVQGISYPGGMCLPYYSTSIIKDLLPD 140
Query: 270 SVYV---VAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLD 326
+ + +AH++GHNLGM+HD C +M + +S+CS+N ++L
Sbjct: 141 TNIIANRMAHQLGHNLGMQHD--EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLK 198
Query: 327 TVQSRCLLD 335
+ C+L+
Sbjct: 199 DYKPTCMLN 207
>AF215824-1|AAG43987.1| 754|Homo sapiens a disintegrin and
metalloproteinase 7 protein.
Length = 754
Score = 49.2 bits (112), Expect = 5e-05
Identities = 49/189 (25%), Positives = 87/189 (46%), Gaps = 27/189 (14%)
Query: 152 VLAMINAVQLLYHDPSLGRPVNFILKRLEI-LHEDPANLKRPHDIDRFLSNFCTWQ-RLE 209
+ M+N V ++Y + ++ L +EI HED L +I+ L F WQ ++
Sbjct: 226 IWGMVNFVNMIYKTLN----IHVTLVGIEIWTHEDKIELYS--NIETTLLRFSFWQEKIL 279
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
D +DH ++L+G LY S V G++ GMC S ++ + +
Sbjct: 280 KTRKD-----FDHVVLLSGKWLY---------SHVQGISYPGGMCLPYYSTSIIKDLLPD 325
Query: 270 SVYV---VAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLD 326
+ + +AH++GHNLGM+HD C +M + +S+CS+N ++L
Sbjct: 326 TNIIANRMAHQLGHNLGMQHD--EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLK 383
Query: 327 TVQSRCLLD 335
+ C+L+
Sbjct: 384 DYKPTCMLN 392
>Y13786-1|CAC20585.1| 918|Homo sapiens meltrin-beta/ADAM 19
homologue protein.
Length = 918
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYV---VAHEIGHNLGMRHDGPS--ADNGCDPSA 299
+GLAP+ MC+V S VN ++ V +AHE+GHN GM HD + + D
Sbjct: 311 IGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGC 370
Query: 300 FLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCL 333
+ + T ++ C++ L ++L + CL
Sbjct: 371 IMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCL 404
>DQ995342-1|ABI97387.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AY358314-1|AAQ88680.1| 813|Homo sapiens Adam33 protein.
Length = 813
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AL356755-2|CAI23465.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AL356755-1|CAM28348.1| 812|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 812
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AL109804-2|CAI18840.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AL109804-1|CAM26955.1| 812|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 812
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AF466288-1|AAM80483.1| 812|Homo sapiens a disintegrin and
metalloprotease domain 33 protein.
Length = 812
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AF466287-1|AAM80482.1| 812|Homo sapiens a disintegrin and
metalloprotease domain 33 protein.
Length = 812
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>AF311317-1|AAK07852.1| 918|Homo sapiens disintegrin and
metalloproteinase ADAM19 protein.
Length = 918
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYV---VAHEIGHNLGMRHDGPS--ADNGCDPSA 299
+GLAP+ MC+V S VN ++ V +AHE+GHN GM HD + + D
Sbjct: 311 IGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGC 370
Query: 300 FLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCL 333
+ + T ++ C++ L ++L + CL
Sbjct: 371 IMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCL 404
>AF134707-1|AAF22162.1| 857|Homo sapiens disintegrin and
metalloproteinase domain 19 protein.
Length = 857
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYV---VAHEIGHNLGMRHDGPS--ADNGCDPSA 299
+GLAP+ MC+V S VN ++ V +AHE+GHN GM HD + + D
Sbjct: 213 IGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGC 272
Query: 300 FLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCL 333
+ + T ++ C++ L ++L + CL
Sbjct: 273 IMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCL 306
>AB055891-1|BAB83092.1| 813|Homo sapiens metalloprotease
disintegrin protein.
Length = 813
Score = 48.0 bits (109), Expect = 1e-04
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFE----SVYVVAHEIGHNLGMRH--DGPSADNGCDPS 298
VGLAPV GMC SS V+ H E + +AHEIGH+LG+ H DG + +
Sbjct: 311 VGLAPVEGMCRAESSGGVSTD-HSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369
Query: 299 AFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCL 333
+M+ G +S CS+ L+ F CL
Sbjct: 370 GCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACL 405
>U41766-1|AAC50403.1| 819|Homo sapiens
metalloprotease/disintegrin/cysteine-rich protein
precursor protein.
Length = 819
Score = 47.2 bits (107), Expect = 2e-04
Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 14/116 (12%)
Query: 232 YVVNKNGKDSSQVV---GLAPVAGMCTVTSSCTVNEG---RHFESVYV------VAHEIG 279
+++ + DS+Q+V G AGM V + C+ + F + V VAHE+G
Sbjct: 291 FLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG 350
Query: 280 HNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCLLD 335
HNLGM HD D C + +M+ + SG +S CS +K CLL+
Sbjct: 351 HNLGMNHD-DGRDCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
>D14665-1|BAA03499.2| 703|Homo sapiens KIAA0021 protein protein.
Length = 703
Score = 47.2 bits (107), Expect = 2e-04
Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 14/116 (12%)
Query: 232 YVVNKNGKDSSQVV---GLAPVAGMCTVTSSCTVNEG---RHFESVYV------VAHEIG 279
+++ + DS+Q+V G AGM V + C+ + F + V VAHE+G
Sbjct: 175 FLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG 234
Query: 280 HNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCLLD 335
HNLGM HD D C + +M+ + SG +S CS +K CLL+
Sbjct: 235 HNLGMNHD-DGRDCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 288
>BC126406-1|AAI26407.1| 712|Homo sapiens ADAM9 protein protein.
Length = 712
Score = 47.2 bits (107), Expect = 2e-04
Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 14/116 (12%)
Query: 232 YVVNKNGKDSSQVV---GLAPVAGMCTVTSSCTVNEG---RHFESVYV------VAHEIG 279
+++ + DS+Q+V G AGM V + C+ + F + V VAHE+G
Sbjct: 291 FLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG 350
Query: 280 HNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCLLD 335
HNLGM HD D C + +M+ + SG +S CS +K CLL+
Sbjct: 351 HNLGMNHD-DGRDCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
>BC060804-1|AAH60804.1| 737|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 737
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 313 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 372
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 373 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 411
>AY358878-1|AAQ89237.1| 735|Homo sapiens ADAM-12 protein.
Length = 735
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 313 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 372
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 373 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 411
>AL589787-6|CAI40683.1| 738|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 738
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 316 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 375
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 376 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
>AL589787-5|CAI40682.1| 909|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 909
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 316 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 375
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 376 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
>AF495383-1|AAM49575.1| 655|Homo sapiens
disintegrin/metalloproteinase domain 9 short protein
precursor protein.
Length = 655
Score = 47.2 bits (107), Expect = 2e-04
Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 14/116 (12%)
Query: 232 YVVNKNGKDSSQVV---GLAPVAGMCTVTSSCTVNEG---RHFESVYV------VAHEIG 279
+++ + DS+Q+V G AGM V + C+ + F + V VAHE+G
Sbjct: 291 FLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELG 350
Query: 280 HNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLDTVQSRCLLD 335
HNLGM HD D C + +M+ + SG +S CS +K CLL+
Sbjct: 351 HNLGMNHD-DGRDCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
>AF023477-1|AAC08703.2| 738|Homo sapiens meltrin-S protein.
Length = 738
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 316 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 375
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 376 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
>AF023476-1|AAC08702.2| 909|Homo sapiens meltrin-L precursor
protein.
Length = 909
Score = 47.2 bits (107), Expect = 2e-04
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 245 VGLAPVAGMCTVTSSCTV---NEGRHFESVYVVAHEIGHNLGMRHD----GPSADNGCDP 297
+G+AP+ MCT S + + + +AHE+GHN GM HD G S +
Sbjct: 316 IGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK 375
Query: 298 SAFLMSPTLG-SGKITWSQCSKNYLQKFLDTVQSRCLLD 335
+M+ + G + +S CS+ L+ L+ CL +
Sbjct: 376 GGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
>BC109025-1|AAI09026.1| 721|Homo sapiens ADAM21 protein protein.
Length = 721
Score = 46.4 bits (105), Expect = 4e-04
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 29/172 (16%)
Query: 119 AIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKR 178
A F+E V V+ D + + N K E V ++N V +Y LG + IL
Sbjct: 206 AWFLELVVVVNHDFFIYSQSNISKVQED-----VFLVVNIVDSMYQQ--LGTYI--ILIG 256
Query: 179 LEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNG 238
+EI ++ N+ I++ L++F W+++ +D H +++ KN
Sbjct: 257 IEIWNQ--GNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAH-----------MFI--KNS 301
Query: 239 KDSSQVVGLAPVAGMCTVTSSCTVN--EGRHFES-VYVVAHEIGHNLGMRHD 287
S ++GLA VAG+C C V+ +G + VAHE+GH LGM+HD
Sbjct: 302 LIS--ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD 351
>BC109024-1|AAI09025.1| 722|Homo sapiens ADAM metallopeptidase
domain 21 protein.
Length = 722
Score = 46.4 bits (105), Expect = 4e-04
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 29/172 (16%)
Query: 119 AIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKR 178
A F+E V V+ D + + N K E V ++N V +Y LG + IL
Sbjct: 207 AWFLELVVVVNHDFFIYSQSNISKVQED-----VFLVVNIVDSMYQQ--LGTYI--ILIG 257
Query: 179 LEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNG 238
+EI ++ N+ I++ L++F W+++ +D H +++ KN
Sbjct: 258 IEIWNQ--GNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAH-----------MFI--KNS 302
Query: 239 KDSSQVVGLAPVAGMCTVTSSCTVN--EGRHFES-VYVVAHEIGHNLGMRHD 287
S ++GLA VAG+C C V+ +G + VAHE+GH LGM+HD
Sbjct: 303 LIS--ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD 352
>AF158644-1|AAD55255.1| 722|Homo sapiens
metalloproteinase-disintegrin protein.
Length = 722
Score = 46.4 bits (105), Expect = 4e-04
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 29/172 (16%)
Query: 119 AIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKR 178
A F+E V V+ D + + N K E V ++N V +Y LG + IL
Sbjct: 207 AWFLELVVVVNHDFFIYSQSNISKVQED-----VFLVVNIVDSMYQQ--LGTYI--ILIG 257
Query: 179 LEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNG 238
+EI ++ N+ I++ L++F W+++ +D H +++ KN
Sbjct: 258 IEIWNQ--GNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAH-----------MFI--KNS 302
Query: 239 KDSSQVVGLAPVAGMCTVTSSCTVN--EGRHFES-VYVVAHEIGHNLGMRHD 287
S ++GLA VAG+C C V+ +G + VAHE+GH LGM+HD
Sbjct: 303 LIS--ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD 352
>AF090327-1|AAC36742.1| 588|Homo sapiens sperm maturation-related
glycoprotein GP-83 protein.
Length = 588
Score = 46.0 bits (104), Expect = 5e-04
Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 27/189 (14%)
Query: 152 VLAMINAVQLLYHDPSLGRPVNFILKRLEI-LHEDPANLKRPHDIDRFLSNFCTWQ-RLE 209
+ M+N V ++Y + ++ L +EI HED L +I+ L F WQ ++
Sbjct: 60 IWGMVNFVNMIYKTLN----IHVTLVGIEIWTHEDKIELYS--NIETTLLRFSFWQEKIL 113
Query: 210 NPPGDNDPLHWDHALILTGLDLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFE 269
D +DH ++L+G LY S V G++ GMC S ++ + +
Sbjct: 114 KTRKD-----FDHVVLLSGKWLY---------SHVQGISYPGGMCLPYYSTSIIKDLLPD 159
Query: 270 SVYV---VAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSGKITWSQCSKNYLQKFLD 326
+ + +AH++GHNLGM+HD C +M + S+C +N ++L
Sbjct: 160 TNIIANRMAHQLGHNLGMQHD--EFPCTCPSGKCVMDSDGSIPALDLSKCRQNQYHQYLK 217
Query: 327 TVQSRCLLD 335
+ C+L+
Sbjct: 218 DYKPTCMLN 226
>AF029900-1|AAC52042.1| 542|Homo sapiens ADAM 21 protein.
Length = 542
Score = 43.6 bits (98), Expect = 0.003
Identities = 49/172 (28%), Positives = 81/172 (47%), Gaps = 29/172 (16%)
Query: 119 AIFVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKR 178
A F+E V V+ D + + N K E V ++N V +Y LG + IL
Sbjct: 27 AWFLELVVVVNHDFFIYSQSNISKVQED-----VFLVVNIVDSMYKQ--LGTYI--ILIG 77
Query: 179 LEILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNG 238
+EI ++ N+ I++ L++F W+++ +D H +++ KN
Sbjct: 78 IEIWNQ--GNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAH-----------MFI--KNS 122
Query: 239 KDSSQVVGLAPVAGMCTVTSSCTVN--EGRHFES-VYVVAHEIGHNLGMRHD 287
S ++GLA VAG+C C V+ +G + VAHE+G+ LGM+HD
Sbjct: 123 LIS--ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGYTLGMQHD 172
>AJ242015-1|CAB42085.1| 775|Homo sapiens eMDC II protein protein.
Length = 775
Score = 41.5 bits (93), Expect = 0.011
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 9/96 (9%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYVVA----HEIGHNLGMRHDGPSADNGCDPSAF 300
VGLA ++ MC+ S V + H +++ VA HE+GHN GM HD S C +
Sbjct: 306 VGLAFMSTMCSPYSVGVVQD--HSDNLLRVAGTMAHEMGHNFGMFHDDYSCK--CPSTIC 361
Query: 301 LMSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD 335
+M L T +S CS+ KF + S CL +
Sbjct: 362 VMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
>AF137335-1|AAD25100.1| 540|Homo sapiens metalloprotease
disintegrin cysteine-rich protein, secreted form MDC-Ls
protein.
Length = 540
Score = 41.5 bits (93), Expect = 0.011
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 9/96 (9%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYVVA----HEIGHNLGMRHDGPSADNGCDPSAF 300
VGLA ++ MC+ S V + H +++ VA HE+GHN GM HD S C +
Sbjct: 306 VGLAFMSTMCSPYSVGVVQD--HSDNLLRVAGTMAHEMGHNFGMFHDDYSCK--CPSTIC 361
Query: 301 LMSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD 335
+M L T +S CS+ KF + S CL +
Sbjct: 362 VMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
>AF137334-1|AAD25099.1| 775|Homo sapiens metalloprotease
disintegrin cysteine-rich protein, transmembrane form
MDC-Lm protein.
Length = 775
Score = 41.5 bits (93), Expect = 0.011
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 9/96 (9%)
Query: 245 VGLAPVAGMCTVTSSCTVNEGRHFESVYVVA----HEIGHNLGMRHDGPSADNGCDPSAF 300
VGLA ++ MC+ S V + H +++ VA HE+GHN GM HD S C +
Sbjct: 306 VGLAFMSTMCSPYSVGVVQD--HSDNLLRVAGTMAHEMGHNFGMFHDDYSCK--CPSTIC 361
Query: 301 LMSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD 335
+M L T +S CS+ KF + S CL +
Sbjct: 362 VMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
>U46005-1|AAC51112.1| 814|Homo sapiens MDC15 protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>U41767-1|AAC50404.1| 814|Homo sapiens metargidin precursor
protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>BT009764-1|AAP88766.1| 814|Homo sapiens a disintegrin and
metalloproteinase domain 15 (metargidin) protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>BC014566-1|AAH14566.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY576417-1|AAS73000.1| 797|Homo sapiens ADAM15 isoform 8 protein.
Length = 797
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560601-1|AAS72999.1| 822|Homo sapiens ADAM15 isoform 7b protein.
Length = 822
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560600-1|AAS72998.1| 821|Homo sapiens ADAM15 isoform 7a protein.
Length = 821
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560599-1|AAS72997.1| 863|Homo sapiens ADAM15 isoform 6b protein.
Length = 863
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560598-1|AAS72996.1| 862|Homo sapiens ADAM15 isoform 6a protein.
Length = 862
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560597-1|AAS72995.1| 838|Homo sapiens ADAM15 isoform 5 protein.
Length = 838
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560596-1|AAS72994.1| 839|Homo sapiens ADAM15 isoform 4a protein.
Length = 839
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560595-1|AAS72993.1| 796|Homo sapiens ADAM15 isoform 3a protein.
Length = 796
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560594-1|AAS72992.1| 814|Homo sapiens ADAM15 isoform 2 protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY560593-1|AAS72991.1| 772|Homo sapiens ADAM15 isoform 1 protein.
Length = 772
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AY518542-1|AAR99331.1| 772|Homo sapiens ADAM-15 precursor protein.
Length = 772
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AL691442-13|CAI15327.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AL451085-35|CAI13274.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-11|AAS72298.1| 797|Homo sapiens ADAM15 isoform 8 protein.
Length = 797
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-10|AAS48596.1| 821|Homo sapiens ADAM15 isoform 7a
protein.
Length = 821
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-9|AAS48597.1| 822|Homo sapiens ADAM15 isoform 7b protein.
Length = 822
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-8|AAS48590.1| 772|Homo sapiens ADAM15 isoform 1 protein.
Length = 772
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-7|AAS48591.1| 796|Homo sapiens ADAM15 isoform 3a protein.
Length = 796
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-6|AAM44189.1| 814|Homo sapiens ADAM15 isoform 2 protein.
Length = 814
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-5|AAS48593.1| 838|Homo sapiens ADAM15 isoform 5 protein.
Length = 838
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-4|AAS48594.1| 862|Homo sapiens ADAM15 isoform 6a protein.
Length = 862
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-3|AAS48592.1| 839|Homo sapiens ADAM15 isoform 4a protein.
Length = 839
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AF314227-2|AAS48595.1| 863|Homo sapiens ADAM15 isoform 6b protein.
Length = 863
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 344
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 345 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 404
Query: 328 VQSRCLLD 335
CL +
Sbjct: 405 GMGSCLFE 412
>AB209157-1|BAD92394.1| 859|Homo sapiens ADAM15 isoform 6a variant
protein.
Length = 859
Score = 41.1 bits (92), Expect = 0.014
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 10/128 (7%)
Query: 218 LHWDHALILTGL--DLYVVNKNGKDSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYV-- 273
LHW A +L L D + S VG+A +C+ S VN + V
Sbjct: 282 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVAS 341
Query: 274 -VAHEIGHNLGMRHDGPSADNGCDPSA-----FLMSPTLGSGKITWSQCSKNYLQKFLDT 327
+AHE+GH+LG+ HD P C A + + T + +S CS+ L+K L
Sbjct: 342 SIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLD 401
Query: 328 VQSRCLLD 335
CL +
Sbjct: 402 GMGSCLFE 409
>AF171931-1|AAF03779.1| 787|Homo sapiens
metallaproteinase-disintegrin gama protein.
Length = 787
Score = 39.9 bits (89), Expect = 0.032
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 246 GLAPVAGMCTVTSSCTV----NEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFL 301
G+ GMCT SC + N+ S+ VAH +GHNLGM HD + C +
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSI-AVAHHLGHNLGMNHDEDTC--RCSQPRCI 355
Query: 302 MSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD--HGNSAGQLDHSAEGIL-PGERFD 357
M G+ IT +S CS ++ +++CLL+ H + G++ GE D
Sbjct: 356 MHE--GNPPITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECD 412
>AF171930-1|AAF03778.1| 766|Homo sapiens
metallaproteinase-disintegrin beta protein.
Length = 766
Score = 39.9 bits (89), Expect = 0.032
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 246 GLAPVAGMCTVTSSCTV----NEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFL 301
G+ GMCT SC + N+ S+ VAH +GHNLGM HD + C +
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSI-AVAHHLGHNLGMNHDEDTC--RCSQPRCI 355
Query: 302 MSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD--HGNSAGQLDHSAEGIL-PGERFD 357
M G+ IT +S CS ++ +++CLL+ H + G++ GE D
Sbjct: 356 MHE--GNPPITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECD 412
>AF171929-1|AAF03777.1| 820|Homo sapiens
metallaproteinase-disintegrin protein.
Length = 820
Score = 39.9 bits (89), Expect = 0.032
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 246 GLAPVAGMCTVTSSCTV----NEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFL 301
G+ GMCT SC + N+ S+ VAH +GHNLGM HD + C +
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSI-AVAHHLGHNLGMNHDEDTC--RCSQPRCI 355
Query: 302 MSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD--HGNSAGQLDHSAEGIL-PGERFD 357
M G+ IT +S CS ++ +++CLL+ H + G++ GE D
Sbjct: 356 MHE--GNPPITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECD 412
>AF134708-1|AAF22163.1| 820|Homo sapiens disintegrin and
metalloproteinase domain 29 protein.
Length = 820
Score = 39.9 bits (89), Expect = 0.032
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 246 GLAPVAGMCTVTSSCTV----NEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFL 301
G+ GMCT SC + N+ S+ VAH +GHNLGM HD + C +
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSI-AVAHHLGHNLGMNHDEDTC--RCSQPRCI 355
Query: 302 MSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD--HGNSAGQLDHSAEGIL-PGERFD 357
M G+ IT +S CS ++ +++CLL+ H + G++ GE D
Sbjct: 356 MHE--GNPPITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECD 412
>AC105914-1|AAY41055.1| 820|Homo sapiens unknown protein.
Length = 820
Score = 39.9 bits (89), Expect = 0.032
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 246 GLAPVAGMCTVTSSCTV----NEGRHFESVYVVAHEIGHNLGMRHDGPSADNGCDPSAFL 301
G+ GMCT SC + N+ S+ VAH +GHNLGM HD + C +
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSI-AVAHHLGHNLGMNHDEDTC--RCSQPRCI 355
Query: 302 MSPTLGSGKIT-WSQCSKNYLQKFLDTVQSRCLLD--HGNSAGQLDHSAEGIL-PGERFD 357
M G+ IT +S CS ++ +++CLL+ H + G++ GE D
Sbjct: 356 MHE--GNPPITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECD 412
>DQ202398-1|ABA43715.1| 465|Homo sapiens ADAM21-like protein
protein.
Length = 465
Score = 39.5 bits (88), Expect = 0.043
Identities = 20/47 (42%), Positives = 29/47 (61%), Gaps = 3/47 (6%)
Query: 244 VVGLAPVAGMCTVTSSCTVN--EGRHFES-VYVVAHEIGHNLGMRHD 287
++GLA +AG+C C V+ +G + VAHE+GH LGM+HD
Sbjct: 136 ILGLAYIAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD 182
>BC025378-1|AAH25378.2| 776|Homo sapiens ADAM metallopeptidase
domain 20 protein.
Length = 776
Score = 37.9 bits (84), Expect = 0.13
Identities = 46/170 (27%), Positives = 69/170 (40%), Gaps = 27/170 (15%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLE 180
FVE V VD Y F + + V ++N V YH V+ IL ++
Sbjct: 258 FVELVVVVDNIRYL-----FSQSNATTVQHEVFNVVNIVDSFYHPLE----VDVILTGID 308
Query: 181 ILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKD 240
I L D+D L +F W+ N+ L D A L++ + G
Sbjct: 309 IWTASNP-LPTSGDLDNVLEDFSIWKNYNL----NNRLQHDVA------HLFIKDTQGMK 357
Query: 241 SSQVVGLAPVAGMCTVTSSCTVN---EGRHFESVYVVAHEIGHNLGMRHD 287
+G+A V G+C + V+ + R + HE+GHNLGM+HD
Sbjct: 358 ----LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD 403
>AF158643-1|AAD55254.1| 726|Homo sapiens
metalloproteinase-disintegrin protein.
Length = 726
Score = 37.9 bits (84), Expect = 0.13
Identities = 46/170 (27%), Positives = 69/170 (40%), Gaps = 27/170 (15%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLE 180
FVE V VD Y F + + V ++N V YH V+ IL ++
Sbjct: 208 FVELVVVVDNIRYL-----FSQSNATTVQHEVFNVVNIVDSFYHPLE----VDVILTGID 258
Query: 181 ILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKD 240
I L D+D L +F W+ N+ L D A L++ + G
Sbjct: 259 IWTASNP-LPTSGDLDNVLEDFSIWKNYNL----NNRLQHDVA------HLFIKDTQGMK 307
Query: 241 SSQVVGLAPVAGMCTVTSSCTVN---EGRHFESVYVVAHEIGHNLGMRHD 287
+G+A V G+C + V+ + R + HE+GHNLGM+HD
Sbjct: 308 ----LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD 353
>AF029899-1|AAC52041.1| 726|Homo sapiens ADAM 20 protein.
Length = 726
Score = 37.9 bits (84), Expect = 0.13
Identities = 46/170 (27%), Positives = 69/170 (40%), Gaps = 27/170 (15%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLE 180
FVE V VD Y F + + V ++N V YH V+ IL ++
Sbjct: 208 FVELVVVVDNIRYL-----FSQSNATTVQHEVFNVVNIVDSFYHPLE----VDVILTGID 258
Query: 181 ILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKD 240
I L D+D L +F W+ N+ L D A L++ + G
Sbjct: 259 IWTASNP-LPTSGDLDNVLEDFSIWKNYNL----NNRLQHDVA------HLFIKDTQGMK 307
Query: 241 SSQVVGLAPVAGMCTVTSSCTVN---EGRHFESVYVVAHEIGHNLGMRHD 287
+G+A V G+C + V+ + R + HE+GHNLGM+HD
Sbjct: 308 ----LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD 353
>U92649-1|AAC39721.1| 824|Homo sapiens snake venom-like protease
protein.
Length = 824
Score = 37.5 bits (83), Expect = 0.17
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-----AFLMSPTLGSG----KITWSQCSKN 319
E+ V HE+GHN G HD P C P+ ++M P SG +S CSK
Sbjct: 398 EADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQ 456
Query: 320 YLQKFLDTVQSRCLLDHGN 338
+ K +++ C + N
Sbjct: 457 SIYKTIESKAQECFQERSN 475
>U86755-1|AAB51586.1| 824|Homo sapiens TNF-alpha converting enzyme
protein.
Length = 824
Score = 37.5 bits (83), Expect = 0.17
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-----AFLMSPTLGSG----KITWSQCSKN 319
E+ V HE+GHN G HD P C P+ ++M P SG +S CSK
Sbjct: 398 EADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQ 456
Query: 320 YLQKFLDTVQSRCLLDHGN 338
+ K +++ C + N
Sbjct: 457 SIYKTIESKAQECFQERSN 475
>U69612-1|AAB53014.1| 694|Homo sapiens TNF-alpha converting enzyme
precursor protein.
Length = 694
Score = 37.5 bits (83), Expect = 0.17
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-----AFLMSPTLGSG----KITWSQCSKN 319
E+ V HE+GHN G HD P C P+ ++M P SG +S CSK
Sbjct: 398 EADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQ 456
Query: 320 YLQKFLDTVQSRCLLDHGN 338
+ K +++ C + N
Sbjct: 457 SIYKTIESKAQECFQERSN 475
>U69611-1|AAB51514.1| 824|Homo sapiens TNF-alpha converting enzyme
protein.
Length = 824
Score = 37.5 bits (83), Expect = 0.17
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-----AFLMSPTLGSG----KITWSQCSKN 319
E+ V HE+GHN G HD P C P+ ++M P SG +S CSK
Sbjct: 398 EADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQ 456
Query: 320 YLQKFLDTVQSRCLLDHGN 338
+ K +++ C + N
Sbjct: 457 SIYKTIESKAQECFQERSN 475
>AC080162-4|AAY14859.1| 543|Homo sapiens unknown protein.
Length = 543
Score = 37.5 bits (83), Expect = 0.17
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 269 ESVYVVAHEIGHNLGMRHDGPSADNGCDPS-----AFLMSPTLGSG----KITWSQCSKN 319
E+ V HE+GHN G HD P C P+ ++M P SG +S CSK
Sbjct: 117 EADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQ 175
Query: 320 YLQKFLDTVQSRCLLDHGN 338
+ K +++ C + N
Sbjct: 176 SIYKTIESKAQECFQERSN 194
>AB095937-1|BAC23113.2| 3051|Homo sapiens KIAA2017 protein protein.
Length = 3051
Score = 37.1 bits (82), Expect = 0.23
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 89 LNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYK---HMTLNFPKDTE 145
+ LA R+ G ++ LA +EK A+Q +ETAV + L H+ + + KD E
Sbjct: 2473 MKLAERSGFGGNRLKFLAMGQGQEKVALQ---LLETAVARGQWLMLQNCHLLVKWLKDLE 2529
Query: 146 RELVRFVLAMINAVQLLYHDPSLGRPVNFILKRLEILHEDPANLK 190
+ L R + L DP+ G P+ + K L+++ E P LK
Sbjct: 2530 KSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLK 2574
>Y13323-1|CAA73764.2| 470|Homo sapiens disintegrin-protease
protein.
Length = 470
Score = 36.3 bits (80), Expect = 0.40
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 31/218 (14%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVR-FVLAMINAVQLLYHDPSLGRPVNFILKRL 179
+++ + +D YK+ N L+R FV ++N + ++Y+ V L +
Sbjct: 219 YIDLYLVLDNAFYKNYNENLT------LIRSFVFDVMNLLNVIYNTID----VQVALVGM 268
Query: 180 EILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGK 239
EI D +K NF W + +H DHA +L+G+
Sbjct: 269 EIW-SDGDKIKVVPSASTTFDNFLRW----HSSNLGKKIH-DHAQLLSGISF-------- 314
Query: 240 DSSQVVGLAPVAGMCTVTSSCTVNEGR--HFESVYVVAHEIGHNLGMRHDGPSADNGCDP 297
+++ VGLA +C+ +S + + + V V++HE+GH LGM D P + C
Sbjct: 315 -NNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM-PDVP-FNTKCPS 371
Query: 298 SAFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCLL 334
+ +M+ L S +S + + +++L + + +CLL
Sbjct: 372 GSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLL 409
>BC074878-1|AAH74878.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 36.3 bits (80), Expect = 0.40
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 31/218 (14%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVR-FVLAMINAVQLLYHDPSLGRPVNFILKRL 179
+++ + +D YK+ N L+R FV ++N + ++Y+ V L +
Sbjct: 219 YIDLYLVLDNAFYKNYNENLT------LIRSFVFDVMNLLNVIYNTID----VQVALVGM 268
Query: 180 EILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGK 239
EI D +K NF W + +H DHA +L+G+
Sbjct: 269 EIW-SDGDKIKVVPSASTTFDNFLRW----HSSNLGKKIH-DHAQLLSGISF-------- 314
Query: 240 DSSQVVGLAPVAGMCTVTSSCTVNEGR--HFESVYVVAHEIGHNLGMRHDGPSADNGCDP 297
+++ VGLA +C+ +S + + + V V++HE+GH LGM D P + C
Sbjct: 315 -NNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM-PDVP-FNTKCPS 371
Query: 298 SAFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCLL 334
+ +M+ L S +S + + +++L + + +CLL
Sbjct: 372 GSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLL 409
>BC074877-1|AAH74877.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 36.3 bits (80), Expect = 0.40
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 31/218 (14%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVR-FVLAMINAVQLLYHDPSLGRPVNFILKRL 179
+++ + +D YK+ N L+R FV ++N + ++Y+ V L +
Sbjct: 219 YIDLYLVLDNAFYKNYNENLT------LIRSFVFDVMNLLNVIYNTID----VQVALVGM 268
Query: 180 EILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGK 239
EI D +K NF W + +H DHA +L+G+
Sbjct: 269 EIW-SDGDKIKVVPSASTTFDNFLRW----HSSNLGKKIH-DHAQLLSGISF-------- 314
Query: 240 DSSQVVGLAPVAGMCTVTSSCTVNEGR--HFESVYVVAHEIGHNLGMRHDGPSADNGCDP 297
+++ VGLA +C+ +S + + + V V++HE+GH LGM D P + C
Sbjct: 315 -NNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM-PDVP-FNTKCPS 371
Query: 298 SAFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCLL 334
+ +M+ L S +S + + +++L + + +CLL
Sbjct: 372 GSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLL 409
>BC069582-1|AAH69582.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 36.3 bits (80), Expect = 0.40
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 31/218 (14%)
Query: 121 FVETAVFVDRDLYKHMTLNFPKDTERELVR-FVLAMINAVQLLYHDPSLGRPVNFILKRL 179
+++ + +D YK+ N L+R FV ++N + ++Y+ V L +
Sbjct: 219 YIDLYLVLDNAFYKNYNENLT------LIRSFVFDVMNLLNVIYNTID----VQVALVGM 268
Query: 180 EILHEDPANLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGK 239
EI D +K NF W + +H DHA +L+G+
Sbjct: 269 EIW-SDGDKIKVVPSASTTFDNFLRW----HSSNLGKKIH-DHAQLLSGISF-------- 314
Query: 240 DSSQVVGLAPVAGMCTVTSSCTVNEGR--HFESVYVVAHEIGHNLGMRHDGPSADNGCDP 297
+++ VGLA +C+ +S + + + V V++HE+GH LGM D P + C
Sbjct: 315 -NNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM-PDVP-FNTKCPS 371
Query: 298 SAFLMSPTLGSG-KITWSQCSKNYLQKFLDTVQSRCLL 334
+ +M+ L S +S + + +++L + + +CLL
Sbjct: 372 GSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLL 409
>X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy
chain protein.
Length = 1934
Score = 35.9 bits (79), Expect = 0.53
Identities = 24/114 (21%), Positives = 53/114 (46%)
Query: 23 DDTKAHIIIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDNT 82
DD K +I I R + LEE + VE+ +++ L D++L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLIN 1724
Query: 83 RLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 QKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1778
>BX641106-1|CAE46049.1| 321|Homo sapiens hypothetical protein
protein.
Length = 321
Score = 35.5 bits (78), Expect = 0.70
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 619 DRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGDN 671
+R C + CQ + +RFY+ + GT C N + CVSG+C G D+
Sbjct: 140 NRKCELNCQ--AMGYRFYVRQAEK--VIDGTPCDQNGTAICVSGQCKSIGCDD 188
>AK131551-1|BAD18685.1| 577|Homo sapiens protein ( Homo sapiens
cDNA FLJ16791 fis, clone TBAES2004105, weakly similar
to ADAM-TS 6 precursor (EC 3.4.24.-). ).
Length = 577
Score = 35.5 bits (78), Expect = 0.70
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 619 DRPCRIACQDERVAHRFYLVNGHEGWFPLGTACGHNNASYCVSGKCLEFGGDN 671
+R C + CQ + +RFY+ + GT C N + CVSG+C G D+
Sbjct: 342 NRKCELNCQ--AMGYRFYVRQAEK--VIDGTPCDQNGTAICVSGQCKSIGCDD 390
>X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain
(1151 AA) protein.
Length = 1151
Score = 34.3 bits (75), Expect = 1.6
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 881 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQNTSLI 940
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 941 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 995
>M25142-1|AAA60387.1| 389|Homo sapiens myosin heavy chain
alpha-subunit protein.
Length = 389
Score = 34.3 bits (75), Expect = 1.6
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 117 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLI 176
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ + +L + + +++ + K+AI A + + ++D H+
Sbjct: 177 NQKKKMEADLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 231
>BC034975-1|AAH34975.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>BC030698-1|AAH30698.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>BC030014-1|AAH30014.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>BC028702-1|AAH28702.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>BC026169-1|AAH26169.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>BC026085-1|AAH26085.1| 787|Homo sapiens ADAM metallopeptidase
domain 32 protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>AY358739-1|AAQ89099.1| 787|Homo sapiens similar to MDC family
protein.
Length = 787
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 273 VVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTL--GSGKITWSQCSKNYLQKFLDTVQS 330
+V + +LG+ +D P C S +M+P + +G T+S CS Q F+ V
Sbjct: 318 IVTQMLALSLGISYDDPKKCQ-CSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGV 376
Query: 331 RCL 333
+CL
Sbjct: 377 KCL 379
>Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1667 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ + +L + + +++ + K+AI A + + ++D H+
Sbjct: 1727 NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781
>X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (
544 AA) protein.
Length = 543
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 273 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLI 332
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 333 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 387
>X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac mRNA
for myosin heavy chain light meromyosin region. ).
Length = 635
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 365 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 424
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 425 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 479
>M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain
beta-subunit protein.
Length = 611
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 341 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLI 400
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 401 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 455
>M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myosin
heavy chain mRNA, 3' end. ).
Length = 524
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 254 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 313
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 314 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 368
>M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myosin
heavy chain mRNA, 3' end. ).
Length = 532
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 261 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 320
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 321 NQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 375
>M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac
myosin heavy chain mRNA, 3' end. ).
Length = 543
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 273 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLI 332
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 333 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 387
>EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6,
cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
protein.
Length = 1939
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1667 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ + +L + + +++ + K+AI A + + ++D H+
Sbjct: 1727 NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781
>BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.7B protein.
Length = 1179
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 909 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 968
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 969 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1023
>AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
>AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypeptide 7,
cardiac muscle, beta variant protein.
Length = 1574
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L +Q+L R + + ++N
Sbjct: 1304 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1363
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1364 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1418
>D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 33.5 bits (73), Expect = 2.8
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 23 DDTKAHI-IIKRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENKPDN 81
DD K +I I++RR LEE + VE+ +++ L D++L R + + ++N
Sbjct: 1667 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLI 1726
Query: 82 TRLKEFKLNLAHRNRTIGKFIEKLATQSIREKRAIQPAIFVETAVFVDRDLYKHM 136
+ K+ +L+ + + +++ + K+AI A + + ++D H+
Sbjct: 1727 NQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSAHL 1781
>Z11887-1|CAA77942.1| 267|Homo sapiens PUMP protein.
Length = 267
Score = 32.7 bits (71), Expect = 4.9
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 8/39 (20%)
Query: 271 VYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSG 309
+Y HE+GH+LGM H DP+A +M PT G+G
Sbjct: 209 LYAATHELGHSLGMGHSS-------DPNA-VMYPTYGNG 239
>X07819-1|CAA30678.1| 267|Homo sapiens protein ( Human pump-1 mRNA
homolog. to metalloproteinase, collagenase and
stromelysin. ).
Length = 267
Score = 32.7 bits (71), Expect = 4.9
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 8/39 (20%)
Query: 271 VYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSG 309
+Y HE+GH+LGM H DP+A +M PT G+G
Sbjct: 209 LYAATHELGHSLGMGHSS-------DPNA-VMYPTYGNG 239
>L22524-1|AAC37543.1| 267|Homo sapiens matrilysin protein.
Length = 267
Score = 32.7 bits (71), Expect = 4.9
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 8/39 (20%)
Query: 271 VYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSG 309
+Y HE+GH+LGM H DP+A +M PT G+G
Sbjct: 209 LYAATHELGHSLGMGHSS-------DPNA-VMYPTYGNG 239
>BC003635-1|AAH03635.1| 267|Homo sapiens matrix metallopeptidase 7
(matrilysin, uterine) protein.
Length = 267
Score = 32.7 bits (71), Expect = 4.9
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 8/39 (20%)
Query: 271 VYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSG 309
+Y HE+GH+LGM H DP+A +M PT G+G
Sbjct: 209 LYAATHELGHSLGMGHSS-------DPNA-VMYPTYGNG 239
>AY795972-1|AAV40839.1| 267|Homo sapiens matrix metalloproteinase 7
(matrilysin, uterine) protein.
Length = 267
Score = 32.7 bits (71), Expect = 4.9
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 8/39 (20%)
Query: 271 VYVVAHEIGHNLGMRHDGPSADNGCDPSAFLMSPTLGSG 309
+Y HE+GH+LGM H DP+A +M PT G+G
Sbjct: 209 LYAATHELGHSLGMGHSS-------DPNA-VMYPTYGNG 239
>D13636-1|BAA02800.1| 911|Homo sapiens KIAA0011 protein.
Length = 911
Score = 32.3 bits (70), Expect = 6.5
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 475 CPGHDKKYQSCHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAA 534
CPG ++ + E F D E S PS+ E P ST RG +SG +
Sbjct: 233 CPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVP-RSTPRGSTSGKQKPHC 291
Query: 535 EWVAASGCHYHCIAP 549
+A +G H +AP
Sbjct: 292 RGMAPNGLPNHIMAP 306
>BC115737-1|AAI15738.1| 1272|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>BC114964-1|AAI14965.1| 1272|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>BC000212-1|AAH00212.1| 585|Homo sapiens GTF3C2 protein protein.
Length = 585
Score = 32.3 bits (70), Expect = 6.5
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 475 CPGHDKKYQSCHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAA 534
CPG ++ + E F D E S PS+ E P ST RG +SG +
Sbjct: 233 CPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVP-RSTPRGSTSGKQKPHC 291
Query: 535 EWVAASGCHYHCIAP 549
+A +G H +AP
Sbjct: 292 RGMAPNGLPNHIMAP 306
>AY013249-1|AAG48509.1| 1272|Homo sapiens hUPF2 protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>AL645617-2|CAI16756.1| 579|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 579
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 73 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 132
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 133 RLDSSLKKNTAFVKKLKTITEQQRDSL 159
>AL645617-1|CAI16755.1| 1272|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>AL138898-5|CAH73459.1| 579|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 579
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 73 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 132
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 133 RLDSSLKKNTAFVKKLKTITEQQRDSL 159
>AL138898-4|CAH73458.1| 1272|Homo sapiens UPF2 regulator of nonsense
transcripts homolog (yeast) protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>AF318574-1|AAG60689.1| 1272|Homo sapiens UPF2 protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>AF301013-1|AAG33225.1| 1272|Homo sapiens regulator of nonsense
transcripts 2 protein.
Length = 1272
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 103 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 162
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 163 RLDSSLKKNTAFVKKLKTITEQQRDSL 189
>AC109828-1|AAY24049.1| 534|Homo sapiens unknown protein.
Length = 534
Score = 32.3 bits (70), Expect = 6.5
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 475 CPGHDKKYQSCHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAA 534
CPG ++ + E F D E S PS+ E P ST RG +SG +
Sbjct: 233 CPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVP-RSTPRGSTSGKQKPHC 291
Query: 535 EWVAASGCHYHCIAP 549
+A +G H +AP
Sbjct: 292 RGMAPNGLPNHIMAP 306
>AB037829-1|BAA92646.1| 1298|Homo sapiens KIAA1408 protein protein.
Length = 1298
Score = 32.3 bits (70), Expect = 6.5
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 129 KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 188
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 189 RLDSSLKKNTAFVKKLKTITEQQRDSL 215
>BT009799-1|AAP88801.1| 911|Homo sapiens general transcription
factor IIIC, polypeptide 2, beta 110kDa protein.
Length = 911
Score = 31.9 bits (69), Expect = 8.6
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 475 CPGHDKKYQSCHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAA 534
CPG ++ + E F D E S PS+ E P ST RG +SG +
Sbjct: 233 CPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVP-RSTPRGSTSGKQKPHC 291
Query: 535 EWVAASGCHYHCIAP 549
+A +G H +AP
Sbjct: 292 RGMAPNGLPDHIMAP 306
>BC020981-1|AAH20981.1| 911|Homo sapiens general transcription
factor IIIC, polypeptide 2, beta 110kDa protein.
Length = 911
Score = 31.9 bits (69), Expect = 8.6
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 475 CPGHDKKYQSCHAEQKFTCSSTVDSEFSLKPSDCEWEALQAAPTESTARGKSSGPWRRAA 534
CPG ++ + E F D E S PS+ E P ST RG +SG +
Sbjct: 233 CPGGEEVDGAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVP-RSTPRGSTSGKQKPHC 291
Query: 535 EWVAASGCHYHCIAP 549
+A +G H +AP
Sbjct: 292 RGMAPNGLPDHIMAP 306
>AK096191-1|BAC04721.1| 579|Homo sapiens protein ( Homo sapiens
cDNA FLJ38872 fis, clone MESAN2013674, highly similar to
Homo sapiens regulator of nonsense transcripts 2 (RENT2)
mRNA. ).
Length = 579
Score = 31.9 bits (69), Expect = 8.6
Identities = 17/87 (19%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 32 KRRMVDTNNHLEENVSCVEKDKKNTTLVDQKLWTKHRRKRDIITENK--PDNTRLKEFKL 89
K++ EE + K+K+ + + Q+ W +H ++++ ++N+ PD+ + F
Sbjct: 73 KKQEEQAKRQQEEEAATQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFS 132
Query: 90 NLAHRNRTIGKFIEKLATQSIREKRAI 116
L + F++KL T + +++ ++
Sbjct: 133 RLDSSLKKNTAFVKKLKTITEQQRDSL 159
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.135 0.426
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 114,743,289
Number of Sequences: 224733
Number of extensions: 5074665
Number of successful extensions: 10160
Number of sequences better than 10.0: 213
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 9645
Number of HSP's gapped (non-prelim): 357
length of query: 754
length of database: 73,234,838
effective HSP length: 96
effective length of query: 658
effective length of database: 51,660,470
effective search space: 33992589260
effective search space used: 33992589260
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 69 (31.9 bits)
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