GeneModel BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001925-TA|BGIBMGA001925-PA|IPR010405|Cofactor of BRCA1
         (587 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BX255925-4|CAM24149.1|  580|Homo sapiens cofactor of BRCA1 (COBR...   542   e-153
AF464935-1|AAL69965.1|  580|Homo sapiens cofactor of BRCA1 protein.   542   e-153
BC011892-1|AAH11892.1|  475|Homo sapiens COBRA1 protein protein.      478   e-134
AK022651-1|BAB14157.1|  475|Homo sapiens protein ( Homo sapiens ...   476   e-134
AB033008-1|BAA86496.1|  210|Homo sapiens KIAA1182 protein protein.    142   3e-33

>BX255925-4|CAM24149.1|  580|Homo sapiens cofactor of BRCA1 (COBRA1)
           protein.
          Length = 580

 Score =  542 bits (1338), Expect = e-153
 Identities = 278/580 (47%), Positives = 368/580 (63%), Gaps = 10/580 (1%)

Query: 11  GLEEVGVPGQTFLRDALTSCTDPLKAIEEFQLENGIXXXXXXXXXXXXXXHGVRRLDFHT 70
           GL+++GV     L++ LT+CT+PLKAIE+FQ ENG+              HG  RL+FH 
Sbjct: 4   GLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQ 63

Query: 71  SVLEELREKLIAHIXXXXXXXXXXXXXXXXXXXXX-XFPVVRVKALRPVIMGILKNIPHI 129
           SV +ELR+KL+  +                       F +V++ +L+PV+M ++K++P +
Sbjct: 64  SVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKV 123

Query: 130 DDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQYIREKEDVLFDHE-NL 188
            +K L++++ D+ELY     EVKRQIWQDNQ+LFGDEVSPLL QYI EKE  LF  E ++
Sbjct: 124 PEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTELSV 183

Query: 189 TNLFFSPSPKVRRQGAVVQKLAHMIGTSVKLYDMVLQXXXXXXXXXXNVHYCTLRAELLM 248
            + FFSPSPK RRQG VVQ+L  M+G +VKLYDMVLQ          NVHYCTLRAELLM
Sbjct: 184 LHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLM 243

Query: 249 ALHDLEVQDIISVDPCHKFTWCLDACIRERNVDIKRSRELQGFLDSIKKGQEQVLGDLSM 308
           +LHDL+V +I +VDPCHKFTWCLDACIRER VD KR+RELQGFLD +KKGQEQVLGDLSM
Sbjct: 244 SLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSM 303

Query: 309 TLCDPYAINFLATSAIKILQHLINTEGLPRDSTVXXXXXXXXXXXXSAWVMIDSQEFKEP 368
            LCDP+AIN LA S ++ LQ L+  E LPRDS               AW MIDSQ FKEP
Sbjct: 304 ILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVFKEP 363

Query: 369 KLDSQCVTKYLPALMSLMVDDQVRALHNKLPPDERESAITTIEHSGPPPDACEAYMRESS 428
           K++ + +T++LP LMS +VDD    +  KLP +E+      + +    P++   +++E  
Sbjct: 364 KMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEK----APVSYPNTLPESFTKFLQEQR 419

Query: 429 VCGVIAMYYTLHAAKLRDRGALLRILSILGSCKDGRAYEDPFLHALVALLVQLPDEFQGE 488
           +   + +YY LH  K R++ ALLR+L  L       A+ D FLH L   L  L DEF  E
Sbjct: 420 MACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALE 479

Query: 489 DFSTVLFDEFFF-AGLSKDNVTRHLLKLLWYIHPKLPETRIQTLMKALQPGTQHNESVHK 547
           DF + LFD FF  A   K+NV RH L+LL ++HP++  ++++ L KAL+P  Q  E+V +
Sbjct: 480 DFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKE 539

Query: 548 LYETLQQKLNA--QTEPGPS-ATEMEYLDSPLMSVRTPAP 584
           LY  L +KL      +P P+ A E   L+ PL SV  PAP
Sbjct: 540 LYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAP 579


>AF464935-1|AAL69965.1|  580|Homo sapiens cofactor of BRCA1 protein.
          Length = 580

 Score =  542 bits (1338), Expect = e-153
 Identities = 278/580 (47%), Positives = 368/580 (63%), Gaps = 10/580 (1%)

Query: 11  GLEEVGVPGQTFLRDALTSCTDPLKAIEEFQLENGIXXXXXXXXXXXXXXHGVRRLDFHT 70
           GL+++GV     L++ LT+CT+PLKAIE+FQ ENG+              HG  RL+FH 
Sbjct: 4   GLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQ 63

Query: 71  SVLEELREKLIAHIXXXXXXXXXXXXXXXXXXXXX-XFPVVRVKALRPVIMGILKNIPHI 129
           SV +ELR+KL+  +                       F +V++ +L+PV+M ++K++P +
Sbjct: 64  SVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKV 123

Query: 130 DDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQYIREKEDVLFDHE-NL 188
            +K L++++ D+ELY     EVKRQIWQDNQ+LFGDEVSPLL QYI EKE  LF  E ++
Sbjct: 124 PEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTELSV 183

Query: 189 TNLFFSPSPKVRRQGAVVQKLAHMIGTSVKLYDMVLQXXXXXXXXXXNVHYCTLRAELLM 248
            + FFSPSPK RRQG VVQ+L  M+G +VKLYDMVLQ          NVHYCTLRAELLM
Sbjct: 184 LHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLM 243

Query: 249 ALHDLEVQDIISVDPCHKFTWCLDACIRERNVDIKRSRELQGFLDSIKKGQEQVLGDLSM 308
           +LHDL+V +I +VDPCHKFTWCLDACIRER VD KR+RELQGFLD +KKGQEQVLGDLSM
Sbjct: 244 SLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSM 303

Query: 309 TLCDPYAINFLATSAIKILQHLINTEGLPRDSTVXXXXXXXXXXXXSAWVMIDSQEFKEP 368
            LCDP+AIN LA S ++ LQ L+  E LPRDS               AW MIDSQ FKEP
Sbjct: 304 ILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVFKEP 363

Query: 369 KLDSQCVTKYLPALMSLMVDDQVRALHNKLPPDERESAITTIEHSGPPPDACEAYMRESS 428
           K++ + +T++LP LMS +VDD    +  KLP +E+      + +    P++   +++E  
Sbjct: 364 KMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEK----APVSYPNTLPESFTKFLQEQR 419

Query: 429 VCGVIAMYYTLHAAKLRDRGALLRILSILGSCKDGRAYEDPFLHALVALLVQLPDEFQGE 488
           +   + +YY LH  K R++ ALLR+L  L       A+ D FLH L   L  L DEF  E
Sbjct: 420 MACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALE 479

Query: 489 DFSTVLFDEFFF-AGLSKDNVTRHLLKLLWYIHPKLPETRIQTLMKALQPGTQHNESVHK 547
           DF + LFD FF  A   K+NV RH L+LL ++HP++  ++++ L KAL+P  Q  E+V +
Sbjct: 480 DFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKE 539

Query: 548 LYETLQQKLNA--QTEPGPS-ATEMEYLDSPLMSVRTPAP 584
           LY  L +KL      +P P+ A E   L+ PL SV  PAP
Sbjct: 540 LYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAP 579


>BC011892-1|AAH11892.1|  475|Homo sapiens COBRA1 protein protein.
          Length = 475

 Score =  478 bits (1178), Expect = e-134
 Identities = 243/476 (51%), Positives = 316/476 (66%), Gaps = 9/476 (1%)

Query: 114 ALRPVIMGILKNIPHIDDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQ 173
           +L+PV+M ++K++P + +K L++++ D+ELY     EVKRQIWQDNQ+LFGDEVSPLL Q
Sbjct: 3   SLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQ 62

Query: 174 YIREKEDVLFDHE-NLTNLFFSPSPKVRRQGAVVQKLAHMIGTSVKLYDMVLQXXXXXXX 232
           YI EKE  LF  E ++ + FFSPSPK RRQG VVQ+L  M+G +VKLYDMVLQ       
Sbjct: 63  YILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFL 122

Query: 233 XXXNVHYCTLRAELLMALHDLEVQDIISVDPCHKFTWCLDACIRERNVDIKRSRELQGFL 292
              NVHYCTLRAELLM+LHDL+V +I +VDPCHKFTWCLDACIRER VD KR+RELQGFL
Sbjct: 123 RTRNVHYCTLRAELLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFL 182

Query: 293 DSIKKGQEQVLGDLSMTLCDPYAINFLATSAIKILQHLINTEGLPRDSTVXXXXXXXXXX 352
           D +KKGQEQVLGDLSM LCDP+AIN LA S ++ LQ L+  E LPRDS            
Sbjct: 183 DGVKKGQEQVLGDLSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLAL 242

Query: 353 XXSAWVMIDSQEFKEPKLDSQCVTKYLPALMSLMVDDQVRALHNKLPPDERESAITTIEH 412
              AW MIDSQ FKEPK++ + +T++LP LMS +VDD    +  KLP +E+      + +
Sbjct: 243 GQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEK----APVSY 298

Query: 413 SGPPPDACEAYMRESSVCGVIAMYYTLHAAKLRDRGALLRILSILGSCKDGRAYEDPFLH 472
               P++   +++E  +   + +YY LH  K R++ ALLR+L  L       A+ D FLH
Sbjct: 299 PNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLH 358

Query: 473 ALVALLVQLPDEFQGEDFSTVLFDEFFF-AGLSKDNVTRHLLKLLWYIHPKLPETRIQTL 531
            L   L  L DEF  EDF + LFD FF  A   K+NV RH L+LL ++HP++  ++++ L
Sbjct: 359 LLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEAL 418

Query: 532 MKALQPGTQHNESVHKLYETLQQKLNA--QTEPGPS-ATEMEYLDSPLMSVRTPAP 584
            KAL+P  Q  E+V +LY  L +KL      +P P+ A E   L+ PL SV  PAP
Sbjct: 419 QKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAP 474


>AK022651-1|BAB14157.1|  475|Homo sapiens protein ( Homo sapiens
           cDNA FLJ12589 fis, clone NT2RM4001258. ).
          Length = 475

 Score =  476 bits (1174), Expect = e-134
 Identities = 242/476 (50%), Positives = 315/476 (66%), Gaps = 9/476 (1%)

Query: 114 ALRPVIMGILKNIPHIDDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQ 173
           +L+PV+M ++K++P + +K L++++ D+ELY     EVKRQIWQDNQ+ FGDEVSPLL Q
Sbjct: 3   SLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQAFFGDEVSPLLKQ 62

Query: 174 YIREKEDVLFDHE-NLTNLFFSPSPKVRRQGAVVQKLAHMIGTSVKLYDMVLQXXXXXXX 232
           YI EKE  LF  E ++ + FFSPSPK RRQG VVQ+L  M+G +VKLYDMVLQ       
Sbjct: 63  YILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFL 122

Query: 233 XXXNVHYCTLRAELLMALHDLEVQDIISVDPCHKFTWCLDACIRERNVDIKRSRELQGFL 292
              NVHYCTLRAELLM+LHDL+V +I +VDPCHKFTWCLDACIRER VD KR+RELQGFL
Sbjct: 123 RTRNVHYCTLRAELLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFL 182

Query: 293 DSIKKGQEQVLGDLSMTLCDPYAINFLATSAIKILQHLINTEGLPRDSTVXXXXXXXXXX 352
           D +KKGQEQVLGDLSM LCDP+AIN LA S ++ LQ L+  E LPRDS            
Sbjct: 183 DGVKKGQEQVLGDLSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLAL 242

Query: 353 XXSAWVMIDSQEFKEPKLDSQCVTKYLPALMSLMVDDQVRALHNKLPPDERESAITTIEH 412
              AW MIDSQ FKEPK++ + +T++LP LMS +VDD    +  KLP +E+      + +
Sbjct: 243 GQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEK----APVSY 298

Query: 413 SGPPPDACEAYMRESSVCGVIAMYYTLHAAKLRDRGALLRILSILGSCKDGRAYEDPFLH 472
               P++   +++E  +   + +YY LH  K R++ ALLR+L  L       A+ D FLH
Sbjct: 299 PNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLH 358

Query: 473 ALVALLVQLPDEFQGEDFSTVLFDEFFF-AGLSKDNVTRHLLKLLWYIHPKLPETRIQTL 531
            L   L  L DEF  EDF + LFD FF  A   K+NV RH L+LL ++HP++  ++++ L
Sbjct: 359 LLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEAL 418

Query: 532 MKALQPGTQHNESVHKLYETLQQKLNA--QTEPGPS-ATEMEYLDSPLMSVRTPAP 584
            KAL+P  Q  E+V +LY  L +KL      +P P+ A E   L+ PL SV  PAP
Sbjct: 419 QKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAP 474


>AB033008-1|BAA86496.1|  210|Homo sapiens KIAA1182 protein protein.
          Length = 210

 Score =  142 bits (344), Expect = 3e-33
 Identities = 82/213 (38%), Positives = 120/213 (56%), Gaps = 8/213 (3%)

Query: 376 TKYLPALMSLMVDDQVRALHNKLPPDERESAITTIEHSGPPPDACEAYMRESSVCGVIAM 435
           T++LP LMS +VDD    +  KLP +E+      + +    P++   +++E  +   + +
Sbjct: 1   TRFLPMLMSFLVDDYTFNVDQKLPAEEK----APVSYPNTLPESFTKFLQEQRMACEVGL 56

Query: 436 YYTLHAAKLRDRGALLRILSILGSCKDGRAYEDPFLHALVALLVQLPDEFQGEDFSTVLF 495
           YY LH  K R++ ALLR+L  L       A+ D FLH L   L  L DEF  EDF + LF
Sbjct: 57  YYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALEDFCSSLF 116

Query: 496 DEFFF-AGLSKDNVTRHLLKLLWYIHPKLPETRIQTLMKALQPGTQHNESVHKLYETLQQ 554
           D FF  A   K+NV RH L+LL ++HP++  ++++ L KAL+P  Q  E+V +LY  L +
Sbjct: 117 DGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGE 176

Query: 555 KLNA--QTEPGPS-ATEMEYLDSPLMSVRTPAP 584
           KL      +P P+ A E   L+ PL SV  PAP
Sbjct: 177 KLEQLDHRKPSPAQAAETPALELPLPSVPAPAP 209


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.321    0.137    0.404 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 78,559,737
Number of Sequences: 224733
Number of extensions: 2993766
Number of successful extensions: 6396
Number of sequences better than 10.0: 5
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 6375
Number of HSP's gapped (non-prelim): 5
length of query: 587
length of database: 73,234,838
effective HSP length: 94
effective length of query: 493
effective length of database: 52,109,936
effective search space: 25690198448
effective search space used: 25690198448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 68 (31.5 bits)