Silkworm BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA001753-TA|BGIBMGA001753-PA|IPR001128|Cytochrome P450
         (536 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...   164   6e-40
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...   163   1e-39
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.       163   1e-39
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...   163   1e-39
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...   163   1e-39
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...   163   1e-39
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...   163   1e-39
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.             163   1e-39
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.               144   5e-34
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.   144   5e-34
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...   144   5e-34
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...   144   5e-34
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...   144   5e-34
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.     144   5e-34
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                143   2e-33
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...   141   5e-33
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...   138   6e-32
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...   138   6e-32
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...   138   6e-32
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...   135   4e-31
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                 134   6e-31
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...   134   7e-31
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.     134   7e-31
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                134   7e-31
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...   134   7e-31
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...   134   7e-31
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...   134   7e-31
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...   134   7e-31
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...   134   7e-31
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.     134   7e-31
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                 134   1e-30
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                 134   1e-30
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                 134   1e-30
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...   134   1e-30
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...   134   1e-30
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...   134   1e-30
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...   134   1e-30
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...   134   1e-30
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...   133   1e-30
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...   132   3e-30
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...   131   5e-30
BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...   123   1e-27
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.     123   1e-27
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...   111   6e-24
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...   110   1e-23
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...   110   1e-23
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...   110   1e-23
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...   110   1e-23
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.     110   1e-23
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...   109   2e-23
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                 109   2e-23
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...   109   2e-23
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...   109   2e-23
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.              109   2e-23
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...   109   3e-23
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...   109   3e-23
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...   108   4e-23
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...   108   6e-23
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...   108   6e-23
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...   108   6e-23
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                  107   1e-22
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...   107   1e-22
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...   107   1e-22
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...   107   1e-22
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...   107   1e-22
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...   107   1e-22
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...   107   1e-22
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...   107   1e-22
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...   107   1e-22
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...   107   1e-22
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...   107   1e-22
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...   107   1e-22
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                 107   1e-22
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...   107   1e-22
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...   107   1e-22
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...   107   1e-22
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.            106   2e-22
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.     106   2e-22
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...   106   2e-22
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...   106   2e-22
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...   106   2e-22
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...   106   2e-22
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.   106   2e-22
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                 106   2e-22
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                 106   2e-22
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...   105   4e-22
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...   105   5e-22
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...   105   5e-22
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...   105   5e-22
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...   104   7e-22
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...   104   9e-22
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...   104   9e-22
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...   104   9e-22
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...   104   9e-22
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...   104   9e-22
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...   104   9e-22
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...   104   9e-22
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...   104   9e-22
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...   103   2e-21
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...   102   3e-21
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...   102   3e-21
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...   102   3e-21
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...   102   3e-21
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...   102   3e-21
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.      102   4e-21
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.      102   4e-21
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...   102   4e-21
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...   102   4e-21
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...   102   4e-21
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...   102   4e-21
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...   101   6e-21
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...    99   3e-20
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                  99   5e-20
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                  99   5e-20
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                 98   6e-20
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...    98   6e-20
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.      98   6e-20
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...    98   6e-20
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...    98   6e-20
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                  97   2e-19
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...    97   2e-19
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...    97   2e-19
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...    97   2e-19
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...    97   2e-19
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                    96   2e-19
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...    96   2e-19
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...    96   2e-19
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...    96   2e-19
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...    96   3e-19
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.        96   3e-19
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...    94   1e-18
DQ359216-1|ABC95161.1|  347|Homo sapiens dioxin-inducible cytoch...    94   1e-18
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...    94   1e-18
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...    94   1e-18
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...    94   1e-18
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...    94   1e-18
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.             93   2e-18
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...    93   3e-18
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                  92   4e-18
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...    92   5e-18
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.        91   1e-17
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.        90   2e-17
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                    90   2e-17
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...    89   3e-17
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.                89   3e-17
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...    89   3e-17
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...    89   5e-17
M29873-1|AAA52143.1|  377|Homo sapiens CYP2B protein.                  89   5e-17
BC041174-1|AAH41174.1|  377|Homo sapiens CYP2B7P1 protein protein.     89   5e-17
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    86   3e-16
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                  86   3e-16
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.      86   3e-16
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.        85   8e-16
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...    84   1e-15
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...    84   1e-15
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    83   2e-15
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...    83   2e-15
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...    82   4e-15
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                 82   4e-15
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...    82   4e-15
BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family...    82   4e-15
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...    82   4e-15
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...    82   4e-15
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...    82   4e-15
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...    82   4e-15
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...    82   4e-15
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...    82   4e-15
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...    82   4e-15
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...    82   4e-15
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...    82   4e-15
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...    82   4e-15
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...    82   4e-15
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                  82   6e-15
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...    82   6e-15
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...    82   6e-15
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.               81   7e-15
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...    81   7e-15
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.       81   7e-15
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.     81   1e-14
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...    80   2e-14
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    80   2e-14
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    80   2e-14
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...    79   3e-14
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...    79   5e-14
J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...    79   5e-14
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...    79   5e-14
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...    79   5e-14
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...    79   5e-14
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...    79   5e-14
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.      79   5e-14
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.      79   5e-14
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.      79   5e-14
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...    79   5e-14
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...    79   5e-14
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...    79   5e-14
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...    78   9e-14
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...    78   9e-14
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...    77   2e-13
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...    76   3e-13
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.       76   3e-13
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...    76   4e-13
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...    76   4e-13
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...    76   4e-13
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...    76   4e-13
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...    74   1e-12
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...    74   1e-12
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...    74   1e-12
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...    74   1e-12
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...    74   1e-12
AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450 epoxyge...    74   1e-12
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...    74   1e-12
BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.      74   1e-12
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...    74   1e-12
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...    74   1e-12
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...    74   1e-12
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...    74   1e-12
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.              74   1e-12
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.      73   3e-12
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...    72   4e-12
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...    71   1e-11
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.              71   1e-11
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...    71   1e-11
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...    71   1e-11
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...    71   1e-11
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.              71   1e-11
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...    70   2e-11
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...    69   4e-11
BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family...    69   6e-11
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...    69   6e-11
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...    69   6e-11
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...    69   6e-11
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...    69   6e-11
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...    67   1e-10
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...    67   1e-10
DQ372705-1|ABD16216.1|  150|Homo sapiens mutant cytochrome p450 ...    67   1e-10
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...    67   1e-10
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...    67   1e-10
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...    67   2e-10
AM236046-1|CAJ84703.1|  229|Homo sapiens cytochrome P450 1A1 pro...    66   2e-10
AM233520-1|CAJ80723.1|  189|Homo sapiens cytochrome P450 1A1 pro...    66   2e-10
AM233519-1|CAJ80722.1|  189|Homo sapiens cytochrome P450 1A1 pro...    66   2e-10
AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...    66   4e-10
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      65   5e-10
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...    64   9e-10
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...    64   9e-10
AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family...    64   9e-10
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...    64   9e-10
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             63   2e-09
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      63   2e-09
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    63   2e-09
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    63   2e-09
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    63   3e-09
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                 63   3e-09
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...    62   4e-09
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                  62   5e-09
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...    61   1e-08
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...    61   1e-08
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.    60   1e-08
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    59   4e-08
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    59   4e-08
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    59   4e-08
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...    58   6e-08
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...    58   6e-08
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...    58   6e-08
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...    58   6e-08
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...    58   6e-08
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.      58   6e-08
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.              58   6e-08
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...    58   6e-08
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...    58   6e-08
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.              58   6e-08
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.               58   6e-08
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.             58   6e-08
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.      58   6e-08
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.      58   6e-08
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...    58   6e-08
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.     57   1e-07
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        56   2e-07
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        56   2e-07
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    56   2e-07
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    56   2e-07
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      56   2e-07
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    56   2e-07
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    56   2e-07
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    56   2e-07
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    56   2e-07
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.      56   2e-07
BC109056-1|AAI09057.1|  320|Homo sapiens CYP2F1 protein protein.       56   3e-07
AF171066-1|AAG43404.1|  112|Homo sapiens CYP1B1 variant protein.       56   3e-07
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...    56   4e-07
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...    56   4e-07
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...    56   4e-07
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...    56   4e-07
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...    56   4e-07
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...    56   4e-07
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    56   4e-07
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...    56   4e-07
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...    56   4e-07
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...    54   1e-06
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    54   1e-06
AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, famil...    54   1e-06
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...    54   1e-06
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    54   1e-06
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    54   1e-06
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...    54   1e-06
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    54   1e-06
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    54   1e-06
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    54   1e-06
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    54   1e-06
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    54   1e-06
DQ211355-2|ABB01373.1|  117|Homo sapiens cytochrome P450 2D6 pro...    53   3e-06
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...    52   7e-06
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    51   9e-06
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    51   1e-05
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    51   1e-05
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    51   1e-05
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    51   1e-05
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    51   1e-05
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    51   1e-05
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    51   1e-05
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...    51   1e-05
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...    51   1e-05
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...    50   2e-05
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...    50   2e-05
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    50   2e-05
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...    50   2e-05
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.       50   2e-05
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...    50   2e-05
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...    50   2e-05
X58904-1|CAA41707.1|  371|Homo sapiens steroid 21-monooxygenase ...    50   2e-05
X58902-1|CAA41706.1|  372|Homo sapiens steroid 21-monooxygenase ...    50   2e-05
X58900-1|CAA41704.1|  372|Homo sapiens steroid 21-monooxygenase ...    50   2e-05
X58898-1|CAA41702.1|  371|Homo sapiens steroid 21-monooxygenase ...    50   2e-05
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    50   2e-05
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  50   2e-05
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    50   2e-05
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...    50   3e-05
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    49   4e-05
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      49   4e-05
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...    49   5e-05
M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxyla...    48   6e-05
M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.                48   8e-05
BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.      48   8e-05
BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.      48   8e-05
BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family...    48   8e-05
BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.      48   8e-05
AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family...    48   8e-05
AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome P-45...    48   8e-05
X58899-1|CAA41703.1|  368|Homo sapiens steroid 21-monooxygenase ...    47   1e-04
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    47   2e-04
X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for ...    46   3e-04
X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase (P-...    46   3e-04
D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase pr...    46   3e-04
BC128535-1|AAI28536.1|  143|Homo sapiens LOC283480 protein protein.    46   3e-04
AY359068-1|AAQ89427.1|  462|Homo sapiens P450-like protein protein.    46   3e-04
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      46   3e-04
BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.     46   4e-04
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.              46   4e-04
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    45   6e-04
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    45   6e-04
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    45   6e-04
BC093022-1|AAH93022.1|  416|Homo sapiens CYP20A1 protein protein.      45   6e-04
BC033752-1|AAH33752.1|  462|Homo sapiens cytochrome P450, family...    45   6e-04
BC020616-1|AAH20616.1|  462|Homo sapiens cytochrome P450, family...    45   6e-04
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    45   6e-04
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    45   6e-04
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    45   6e-04
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      45   6e-04
AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    45   6e-04
AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    45   6e-04
AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    45   6e-04
AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    45   6e-04
AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    45   6e-04
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    45   6e-04
M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid 1...    45   8e-04
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      45   8e-04
L16880-1|AAD13466.1|  273|Homo sapiens cytochrome P-450 2C protein.    44   0.001
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    44   0.001
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    43   0.002
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             43   0.002
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      43   0.002
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    43   0.002
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    43   0.002
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    43   0.002
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    43   0.002
AF183412-1|AAG09681.1|  435|Homo sapiens cytochrome P450 monooxy...    43   0.002
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...    43   0.003
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                 43   0.003
BC070317-1|AAH70317.1|  162|Homo sapiens CYP2C9 protein protein.       43   0.003
BC020754-1|AAH20754.1|  162|Homo sapiens CYP2C9 protein protein.       43   0.003
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.              42   0.004
S63426-1|ABB76283.1|  214|Homo sapiens (S)-mephenytoin hydroxyla...    42   0.004
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...    42   0.004
AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family...    42   0.007
L39098-1|AAL31347.1|  160|Homo sapiens S-mephenytoin 4-hydroxyla...    41   0.010
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    41   0.013
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    41   0.013
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    41   0.013
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    40   0.022
AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family...    40   0.029
AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family...    40   0.029
AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxyla...    40   0.029
AY904366-1|AAW83816.1|   62|Homo sapiens cytochrome p4502C9 prot...    39   0.039
BC029155-1|AAH29155.1|  489|Homo sapiens Unknown (protein for IM...    38   0.068
AF176805-1|AAK11850.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.068
AF127090-1|AAD20021.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.068
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    38   0.089
AF029403-1|AAC95426.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.089
X58908-1|CAA41711.1|   97|Homo sapiens steroid 21-monooxygenase ...    34   1.1  
X58907-1|CAA41710.1|  369|Homo sapiens steroid 21-monooxygenase ...    34   1.1  
U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha demet...    33   3.4  
BC012027-1|AAH12027.1|  168|Homo sapiens CYP2U1 protein protein.       33   3.4  
D12621-1|BAA02145.1|  389|Homo sapiens cytochrome P-450LTBV prot...    32   5.9  

>BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  164 bits (399), Expect = 6e-40
 Identities = 114/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAMANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  SFIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSSFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDK 448


>U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochrome
           P450 protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDK 448


>U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDK 448


>BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDK 448


>BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDK 448


>AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDK 448


>AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1
           protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDK 448


>AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.
          Length = 543

 Score =  163 bits (397), Expect = 1e-39
 Identities = 113/409 (27%), Positives = 197/409 (48%), Gaps = 25/409 (6%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V + E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHVLS-EARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLLRVLHEDPT---------MDRNTIIFMLEDFLGG-HSSVGNLV 323
           E +L   A  +D +D  +    +            +D   +   + D  G    ++   +
Sbjct: 281 E-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTAL 339

Query: 324 MLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-V 381
              L    R P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ +
Sbjct: 340 QWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

Query: 382 PHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           PH  T N ++ GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDK 448


>X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSLVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWDWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.
          Length = 512

 Score =  144 bits (350), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.
          Length = 512

 Score =  143 bits (346), Expect = 2e-33
 Identities = 108/403 (26%), Positives = 187/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   +F+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPAEFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +N+ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433


>AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  141 bits (342), Expect = 5e-33
 Identities = 108/403 (26%), Positives = 186/403 (46%), Gaps = 20/403 (4%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWDWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTD 156
            L + G+   GRPD   F  L +  ++ S +      W+                     
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 157 SHARIGTVGTFESVE-LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
           S +        +  E LI TL+ L +        + +++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKGAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V       L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTATSWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVA 385
             +  +P V RKI++E+D V    R   L+DRSHLPY EA ILE  R++S  P  +PH  
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 386 TENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           T + ++ G+ I KG  VF+N + +++ ++ W  P +F P RFL
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERFL 433


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  138 bits (333), Expect = 6e-32
 Identities = 113/404 (27%), Positives = 187/404 (46%), Gaps = 31/404 (7%)

Query: 44  PGPVCWPIIGSLH-LLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLN 102
           PGP   P IG+++ L    E P     + S+ YG+IFS+ LG    VV+N   +++E L 
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100

Query: 103 QNGNVVAGRPDFLRFHKLFA-GDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARI 161
               + A RP    F K+   G   NS     W             + G  Q +     +
Sbjct: 101 HQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW-VDHRRLAVNSFRYFGYGQKSFESKIL 159

Query: 162 GTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
                F   + I+T KG         D K ++  +  N+ +  +   RF  ED +FQ ++
Sbjct: 160 EETKFFN--DAIETYKG------RPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211

Query: 222 DHFDEIFWEINQGYAV---DFLPWLAPF-YKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           + F E   E+    +V   +  PW+    + KH +   N +  +  F LSR++E+  +N 
Sbjct: 212 ELFSENV-ELAASASVFLYNAFPWIGILPFGKHQQLFRN-AAVVYDF-LSRLIEKASVNR 268

Query: 278 DTEAPEKDFLDGLLRVLHE---DP--TMDRNTIIFML-EDFLGGHSSVGNLVMLCLTAVA 331
             + P+  F+D  L  + +   DP  T  +  +IF + E  + G  +  N++   +  +A
Sbjct: 269 KPQLPQH-FVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASSPIVP----HVATE 387
             P +  ++++EID +          D+  +PYTEA + E LR+ +  IVP    H  +E
Sbjct: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN--IVPLGIFHATSE 385

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKT 431
           +A + GY I KGT V  N Y ++  E+YW +PE F P RFL+ +
Sbjct: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429



 Score = 34.3 bits (75), Expect = 1.1
 Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 474 IPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV--ENINDLKQKPACVALPK 525
           +PFS+G+R C+G+ +     F  F  ++Q F +    E + DLK +      P+
Sbjct: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ 492


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  138 bits (333), Expect = 6e-32
 Identities = 113/404 (27%), Positives = 187/404 (46%), Gaps = 31/404 (7%)

Query: 44  PGPVCWPIIGSLH-LLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLN 102
           PGP   P IG+++ L    E P     + S+ YG+IFS+ LG    VV+N   +++E L 
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100

Query: 103 QNGNVVAGRPDFLRFHKLFA-GDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARI 161
               + A RP    F K+   G   NS     W             + G  Q +     +
Sbjct: 101 HQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW-VDHRRLAVNSFRYFGYGQKSFESKIL 159

Query: 162 GTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
                F   + I+T KG         D K ++  +  N+ +  +   RF  ED +FQ ++
Sbjct: 160 EETKFFN--DAIETYKG------RPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211

Query: 222 DHFDEIFWEINQGYAV---DFLPWLAPF-YKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           + F E   E+    +V   +  PW+    + KH +   N +  +  F LSR++E+  +N 
Sbjct: 212 ELFSENV-ELAASASVFLYNAFPWIGILPFGKHQQLFRN-AAVVYDF-LSRLIEKASVNR 268

Query: 278 DTEAPEKDFLDGLLRVLHE---DP--TMDRNTIIFML-EDFLGGHSSVGNLVMLCLTAVA 331
             + P+  F+D  L  + +   DP  T  +  +IF + E  + G  +  N++   +  +A
Sbjct: 269 KPQLPQH-FVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASSPIVP----HVATE 387
             P +  ++++EID +          D+  +PYTEA + E LR+ +  IVP    H  +E
Sbjct: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN--IVPLGIFHATSE 385

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKT 431
           +A + GY I KGT V  N Y ++  E+YW +PE F P RFL+ +
Sbjct: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429



 Score = 34.3 bits (75), Expect = 1.1
 Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 474 IPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV--ENINDLKQKPACVALPK 525
           +PFS+G+R C+G+ +     F  F  ++Q F +    E + DLK +      P+
Sbjct: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ 492


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score =  138 bits (333), Expect = 6e-32
 Identities = 113/404 (27%), Positives = 187/404 (46%), Gaps = 31/404 (7%)

Query: 44  PGPVCWPIIGSLH-LLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLN 102
           PGP   P IG+++ L    E P     + S+ YG+IFS+ LG    VV+N   +++E L 
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100

Query: 103 QNGNVVAGRPDFLRFHKLFA-GDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARI 161
               + A RP    F K+   G   NS     W             + G  Q +     +
Sbjct: 101 HQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW-VDHRRLAVNSFRYFGYGQKSFESKIL 159

Query: 162 GTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
                F   + I+T KG         D K ++  +  N+ +  +   RF  ED +FQ ++
Sbjct: 160 EETKFFN--DAIETYKG------RPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211

Query: 222 DHFDEIFWEINQGYAV---DFLPWLAPF-YKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           + F E   E+    +V   +  PW+    + KH +   N +  +  F LSR++E+  +N 
Sbjct: 212 ELFSENV-ELAASASVFLYNAFPWIGILPFGKHQQLFRN-AAVVYDF-LSRLIEKASVNR 268

Query: 278 DTEAPEKDFLDGLLRVLHE---DP--TMDRNTIIFML-EDFLGGHSSVGNLVMLCLTAVA 331
             + P+  F+D  L  + +   DP  T  +  +IF + E  + G  +  N++   +  +A
Sbjct: 269 KPQLPQH-FVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASSPIVP----HVATE 387
             P +  ++++EID +          D+  +PYTEA + E LR+ +  IVP    H  +E
Sbjct: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN--IVPLGIFHATSE 385

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKT 431
           +A + GY I KGT V  N Y ++  E+YW +PE F P RFL+ +
Sbjct: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429



 Score = 34.3 bits (75), Expect = 1.1
 Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 474 IPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV--ENINDLKQKPACVALPK 525
           +PFS+G+R C+G+ +     F  F  ++Q F +    E + DLK +      P+
Sbjct: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ 492


>AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2
           protein.
          Length = 516

 Score =  135 bits (326), Expect = 4e-31
 Identities = 119/481 (24%), Positives = 208/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E++ LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAMALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDVFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  134 bits (325), Expect = 6e-31
 Identities = 108/394 (27%), Positives = 189/394 (47%), Gaps = 25/394 (6%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQE- 149

Query: 170 VELIQTLKG-LTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIF 228
              I TL   L + +  SID+   +  +  N+ S    +  + + D E   I ++ + I 
Sbjct: 150 ---ISTLSDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGII 206

Query: 229 WEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLD 288
             +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD
Sbjct: 207 DNLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLD 264

Query: 289 GLLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEV 336
            L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V
Sbjct: 265 TLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQV 324

Query: 337 GRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGY 394
            +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  +
Sbjct: 325 KKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEF 384

Query: 395 GIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
            ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 385 AVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for
           cytochrome P-3-450. ).
          Length = 515

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.
          Length = 515

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.
          Length = 515

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score =  134 bits (324), Expect = 7e-31
 Identities = 119/481 (24%), Positives = 207/481 (43%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  134 bits (323), Expect = 1e-30
 Identities = 106/393 (26%), Positives = 187/393 (47%), Gaps = 23/393 (5%)

Query: 50  PIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVA 109
           P++GSL  L  H      F +L KKYG I+SV++G+   V+V +  L +EVL + G   +
Sbjct: 35  PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFS 94

Query: 110 GRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFES 169
           GRP         A +    +A  D                      D   ++  +   E 
Sbjct: 95  GRPQMATLD--IASNNRKGIAFADSGAHWQLHRRLAMATFA--LFKDGDQKLEKIICQEI 150

Query: 170 VELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW 229
             L   L    + +  SID+   +  +  N+ S    +  + + D E   I ++ + I  
Sbjct: 151 STLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207

Query: 230 EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG 289
            +++   VD +PWL  F  K +EKL +  + IR+ +L++I+E  +    +++   + LD 
Sbjct: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVK-IRNDLLNKILENYKEKFRSDSIT-NMLDT 265

Query: 290 LLRV-LHED-----PTMDR-----NTIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVG 337
           L++  ++ D     P  D      N I+  + D  G G  +  ++V   L  +  +P+V 
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325

Query: 338 RKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRY--ASSPIVPHVATENANISGYG 395
           +K+ +EID      R   ++DR+ L   EATI E LR    +  ++PH A  +++I  + 
Sbjct: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385

Query: 396 IEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           ++KGT V IN + L+++E+ W +P++F P RFL
Sbjct: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPK 525
           ++PF  G R+CIG+ +     F + A ++Q F++    + D  Q P+   +PK
Sbjct: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL---EVPDDGQLPSLEGIPK 481


>L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrome
           P-450 4 gene, exon 7, and three Alu repeats in the 3'
           flank. ).
          Length = 516

 Score =  133 bits (322), Expect = 1e-30
 Identities = 119/481 (24%), Positives = 206/481 (42%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  + +GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQISIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  132 bits (319), Expect = 3e-30
 Identities = 118/481 (24%), Positives = 206/481 (42%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++GS   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++   P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSPFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  131 bits (317), Expect = 5e-30
 Identities = 118/481 (24%), Positives = 206/481 (42%), Gaps = 48/481 (9%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L++ P P  WP++G +  LG  ++P  A + +S++YGD+  +++ S   +V++ L  IR+
Sbjct: 39  LKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIDSTPVLVLSRLDTIRQ 96

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHC-GPKQHT 155
            L + G+   GRPD L    L    ++ + +      W+                    +
Sbjct: 97  ALVRQGDDFKGRPD-LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            S   +    + E+  LI  L+ L +      D    ++ S  N+         F +   
Sbjct: 156 SSSCYLEEHVSKEAKALISRLQELMA-GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD 214

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V +  E     + G  +DF P L       +++   ++Q    F L + V++   
Sbjct: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQ 273

Query: 276 NLDTEAPEKDFLDGLLRVLHEDPTMDRNTI-----IFMLEDFLG-GHSSVGNLVMLCLTA 329
           + D  +  +D    L +   + P    N I     + ++ D  G G  +V   +   L  
Sbjct: 274 DFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   PE+ RKI++E+D V   +R   L+DR  LPY EA ILE  R++S  P  +PH  T 
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLES 447
           +  ++G+ I K   VF+N + +N+  + W +P +F P RFL                   
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL------------------- 433

Query: 448 DSERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVG 507
            ++   + KP  E+ ML           F +GKR CIG+ +     F   A ++Q  E  
Sbjct: 434 TADGTAINKPLSEKMML-----------FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 508 V 508
           V
Sbjct: 483 V 483


>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score =  123 bits (297), Expect = 1e-27
 Identities = 80/247 (32%), Positives = 133/247 (53%), Gaps = 19/247 (7%)

Query: 199 NMFSNYMCSV----RFDDEDLEFQKIVDHFDEIFWEI---NQGYAVDFLPWLAPFYKKHM 251
           N  SN +CS+    RFD  + EF+K++        EI   +Q   V+  PWL        
Sbjct: 226 NAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGL-EICLNSQVLLVNICPWLYYLPFGPF 284

Query: 252 EKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHED------PTMDRNTI 305
           ++L    +DI SF L +I++  + +LD E P+ DF+D  L  + E+       + D   +
Sbjct: 285 KELRQIEKDITSF-LKKIIKDHQESLDRENPQ-DFIDMYLLHMEEERKNNSNSSFDEEYL 342

Query: 306 IFMLED-FLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPY 364
            +++ D F+ G  +  N ++ CL  ++ +P+V  K+ +EI+ V    R   LTD++ +PY
Sbjct: 343 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 402

Query: 365 TEATILECLRY-ASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKF 422
           TEATI+E  R     P+ +PH+ +EN  + GY I KGT++  N + ++     W +PE F
Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDF 462

Query: 423 DPSRFLE 429
            P+RFL+
Sbjct: 463 YPNRFLD 469



 Score = 42.3 bits (95), Expect = 0.004
 Identities = 17/32 (53%), Positives = 22/32 (68%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSF 504
           FIPF IGKR C+G+ +     F MF ++MQSF
Sbjct: 480 FIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511



 Score = 32.7 bits (71), Expect = 3.4
 Identities = 17/49 (34%), Positives = 25/49 (51%)

Query: 64  PFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           P      L++ YG IFS  +G    VV+++   +RE L Q   V + RP
Sbjct: 103 PQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRP 151


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score =  123 bits (297), Expect = 1e-27
 Identities = 80/247 (32%), Positives = 133/247 (53%), Gaps = 19/247 (7%)

Query: 199 NMFSNYMCSV----RFDDEDLEFQKIVDHFDEIFWEI---NQGYAVDFLPWLAPFYKKHM 251
           N  SN +CS+    RFD  + EF+K++        EI   +Q   V+  PWL        
Sbjct: 226 NAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGL-EICLNSQVLLVNICPWLYYLPFGPF 284

Query: 252 EKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHED------PTMDRNTI 305
           ++L    +DI SF L +I++  + +LD E P+ DF+D  L  + E+       + D   +
Sbjct: 285 KELRQIEKDITSF-LKKIIKDHQESLDRENPQ-DFIDMYLLHMEEERKNNSNSSFDEEYL 342

Query: 306 IFMLED-FLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPY 364
            +++ D F+ G  +  N ++ CL  ++ +P+V  K+ +EI+ V    R   LTD++ +PY
Sbjct: 343 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 402

Query: 365 TEATILECLRY-ASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKF 422
           TEATI+E  R     P+ +PH+ +EN  + GY I KGT++  N + ++     W +PE F
Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDF 462

Query: 423 DPSRFLE 429
            P+RFL+
Sbjct: 463 YPNRFLD 469



 Score = 42.3 bits (95), Expect = 0.004
 Identities = 17/32 (53%), Positives = 22/32 (68%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSF 504
           FIPF IGKR C+G+ +     F MF ++MQSF
Sbjct: 480 FIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511



 Score = 32.7 bits (71), Expect = 3.4
 Identities = 17/49 (34%), Positives = 25/49 (51%)

Query: 64  PFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           P      L++ YG IFS  +G    VV+++   +RE L Q   V + RP
Sbjct: 103 PQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRP 151


>BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  111 bits (267), Expect = 6e-24
 Identities = 104/400 (26%), Positives = 171/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +   +
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K+
Sbjct: 148 E------EAQCLIEELR---KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLTYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP KD +D  L  + E+ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-KDLIDTYLLHMEEEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score =  110 bits (264), Expect = 1e-23
 Identities = 100/408 (24%), Positives = 181/408 (44%), Gaps = 32/408 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
                  RP       +F   + N L +     W                 K+  +   +
Sbjct: 104 MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  L + +K     +    D    +  +  N+  +     RF+ +D  FQ++
Sbjct: 161 ------EEAQHLTEAIK---EENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 221 VDHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +   DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + 
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDW 269

Query: 278 DTEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           +  A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A
Sbjct: 270 N-PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 332 RDPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
             PE+  K++ EID V  +G++P     R  +PYT A I E  R  +  P+ VP   T +
Sbjct: 329 LYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTR 436
             ++GY + KGT++  N   L+     W+ P+ F+P  FLE  + + R
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKR 435



 Score = 41.1 bits (92), Expect = 0.010
 Identities = 18/45 (40%), Positives = 25/45 (55%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQK 517
           F+PFSIGKR C+G+ +  +  F  F ++MQ F     N   L  K
Sbjct: 438 FMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 500

 Score =  110 bits (264), Expect = 1e-23
 Identities = 96/400 (24%), Positives = 169/400 (42%), Gaps = 17/400 (4%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                 +        
Sbjct: 91  LVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTL--RNLGLGKKS 148

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           +    T E+  L       + R         +L K+  N+ ++  C  RF+ +D  F ++
Sbjct: 149 LEQWVTEEAACLCAAFANHSGRPFRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRL 208

Query: 221 VDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREINL 277
           +D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +  
Sbjct: 209 LDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRMTW 265

Query: 278 DTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  + 
Sbjct: 266 DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMI 325

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
             P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + + 
Sbjct: 326 LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI 385

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
            + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 386 EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 425



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 436 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 471


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  110 bits (264), Expect = 1e-23
 Identities = 100/408 (24%), Positives = 181/408 (44%), Gaps = 32/408 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
                  RP       +F   + N L +     W                 K+  +   +
Sbjct: 104 MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  L + +K     +    D    +  +  N+  +     RF+ +D  FQ++
Sbjct: 161 ------EEAQHLTEAIK---EENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 221 VDHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +   DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + 
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDW 269

Query: 278 DTEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           +  A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A
Sbjct: 270 N-PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 332 RDPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
             PE+  K++ EID V  +G++P     R  +PYT A I E  R  +  P+ VP   T +
Sbjct: 329 LYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTR 436
             ++GY + KGT++  N   L+     W+ P+ F+P  FLE  + + R
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKR 435



 Score = 41.1 bits (92), Expect = 0.010
 Identities = 18/45 (40%), Positives = 25/45 (55%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQK 517
           F+PFSIGKR C+G+ +  +  F  F ++MQ F     N   L  K
Sbjct: 438 FMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  110 bits (264), Expect = 1e-23
 Identities = 100/408 (24%), Positives = 181/408 (44%), Gaps = 32/408 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
                  RP       +F   + N L +     W                 K+  +   +
Sbjct: 104 MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  L + +K     +    D    +  +  N+  +     RF+ +D  FQ++
Sbjct: 161 ------EEAQHLTEAIK---EENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 221 VDHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +   DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + 
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDW 269

Query: 278 DTEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           +  A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A
Sbjct: 270 N-PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 332 RDPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
             PE+  K++ EID V  +G++P     R  +PYT A I E  R  +  P+ VP   T +
Sbjct: 329 LYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTR 436
             ++GY + KGT++  N   L+     W+ P+ F+P  FLE  + + R
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKR 435



 Score = 41.1 bits (92), Expect = 0.010
 Identities = 18/45 (40%), Positives = 25/45 (55%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQK 517
           F+PFSIGKR C+G+ +  +  F  F ++MQ F     N   L  K
Sbjct: 438 FMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score =  110 bits (264), Expect = 1e-23
 Identities = 100/408 (24%), Positives = 181/408 (44%), Gaps = 32/408 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
                  RP       +F   + N L +     W                 K+  +   +
Sbjct: 104 MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  L + +K     +    D    +  +  N+  +     RF+ +D  FQ++
Sbjct: 161 ------EEAQHLTEAIK---EENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 221 VDHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +   DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + 
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDW 269

Query: 278 DTEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           +  A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A
Sbjct: 270 N-PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 332 RDPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
             PE+  K++ EID V  +G++P     R  +PYT A I E  R  +  P+ VP   T +
Sbjct: 329 LYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTR 436
             ++GY + KGT++  N   L+     W+ P+ F+P  FLE  + + R
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKR 435



 Score = 41.1 bits (92), Expect = 0.010
 Identities = 18/45 (40%), Positives = 25/45 (55%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQK 517
           F+PFSIGKR C+G+ +  +  F  F ++MQ F     N   L  K
Sbjct: 438 FMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2
           protein.
          Length = 502

 Score =  109 bits (263), Expect = 2e-23
 Identities = 100/408 (24%), Positives = 181/408 (44%), Gaps = 32/408 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
                  RP       +F   + N L +     W                 K+  +   +
Sbjct: 104 MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  L + +K     +    D    +  +  N+  +     RF+ +D  FQ++
Sbjct: 161 ------EEAQHLTEAIK---EENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 221 VDHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +   DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + 
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDW 269

Query: 278 DTEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           +  A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A
Sbjct: 270 N-PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328

Query: 332 RDPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
             PE+  K++ EID V  +G++P     R  +PYT A I E  R  +  P+ VP   T +
Sbjct: 329 LYPEIQEKVQVEIDRVIGQGQQP-STAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTR 436
             ++GY + KGT++  N   L+     W+ P+ F+P  FLE  + + R
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKR 435



 Score = 41.1 bits (92), Expect = 0.010
 Identities = 18/45 (40%), Positives = 25/45 (55%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQK 517
           F+PFSIGKR C+G+ +  +  F  F ++MQ F     N   L  K
Sbjct: 438 FMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.
          Length = 491

 Score =  109 bits (262), Expect = 2e-23
 Identities = 103/400 (25%), Positives = 171/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +   +
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K+
Sbjct: 148 E------EAQCLIEELR---KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP KD +D  L  + ++ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  109 bits (262), Expect = 2e-23
 Identities = 103/400 (25%), Positives = 171/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +   +
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K+
Sbjct: 148 E------EAQCLIEELR---KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP KD +D  L  + ++ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6
           protein.
          Length = 491

 Score =  109 bits (262), Expect = 2e-23
 Identities = 101/400 (25%), Positives = 170/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +    
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEER-- 145

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                T E  + +  ++ L     A +D   +      N+  + +   RF  +D EF K+
Sbjct: 146 -----TQEEAQCL--IEELRKSKGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN-PQEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP +D +D  L  + ++ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-RDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.
          Length = 491

 Score =  109 bits (262), Expect = 2e-23
 Identities = 103/400 (25%), Positives = 171/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +   +
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K+
Sbjct: 148 E------EAQCLIEELR---KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP KD +D  L  + ++ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  109 bits (261), Expect = 3e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  109 bits (261), Expect = 3e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  108 bits (260), Expect = 4e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDEVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTKEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 173/402 (43%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R +PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYSPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 496

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/401 (23%), Positives = 172/401 (42%), Gaps = 23/401 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH-----EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
             D   P +D  +  L  +      E    D N  I + + F  G  +    +   L  +
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM 320

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATEN 388
              P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + +
Sbjct: 321 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD 380

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
             + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 421



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 432 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 467


>DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 173/402 (43%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R +PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYSPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 173/402 (43%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R +PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYSPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 173/402 (43%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R +PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYSPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.7 bits (81), Expect = 0.21
 Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 2/65 (3%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQ--SFEVGVENINDLKQKPACVALPKNTYKM 530
           F+PFS G+R C+G+ +     F  F +++Q  SF V          +     +  + Y++
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPYEL 492

Query: 531 HLIPR 535
             +PR
Sbjct: 493 CAVPR 497


>BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  108 bits (259), Expect = 6e-23
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.
          Length = 490

 Score =  107 bits (257), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 415



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 480 PP-SYQICFIP 489


>M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  107 bits (257), Expect = 1e-22
 Identities = 102/400 (25%), Positives = 171/400 (42%), Gaps = 24/400 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE 
Sbjct: 29  RLPPGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L       +GR         F G          W                 K+  +   +
Sbjct: 88  LVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
                  E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K+
Sbjct: 148 E------EAQCLIEELR---KSKGALMDPTFLFHSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 221 VDHFDEIFWEINQ--GYAVD-FLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           ++ F + F  I+   G   + F  +L  F   H +   N  Q+I ++I   + + RE  L
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TL 256

Query: 278 DTEAPEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           D  AP +D +D  L  + ++ +        +N  +  L  F  G  +    +      + 
Sbjct: 257 DPSAP-RDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENA 389
           + P V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R++   P+ VPH+ T++ 
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  GY I K T VF+      +   Y+ +P+ F+P  FL+
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415



 Score = 46.0 bits (104), Expect = 3e-04
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFE---- 505
           E+     PD   +     K    FIPFS+GKR C+G+ +  +  F  F  I+Q+F     
Sbjct: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462

Query: 506 VGVENINDLKQKPACVALPKNTYKMHLIPR 535
           V  E+I DL  +   V     TY++  +PR
Sbjct: 463 VAPEDI-DLTPQECGVGKIPPTYQIRFLPR 491


>AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6
           protein.
          Length = 497

 Score =  107 bits (257), Expect = 1e-22
 Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  107 bits (257), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 415



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 480 PP-SYQICFIP 489


>AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  107 bits (257), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 415



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 480 PP-SYQICFIP 489


>M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.
          Length = 480

 Score =  107 bits (256), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 21  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 79

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 80  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 137

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D +F  ++  
Sbjct: 138 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQKFLTLMKR 190

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 191 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT-RSYIREK-VKEHQASLDVN 248

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 249 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 307

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 308 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 367

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 368 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGLFLDK 405



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 410 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 469

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 470 PP-SYQICFIP 479


>M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrome
           P-450 1 functional form mRNA, complete cds. ).
          Length = 490

 Score =  107 bits (256), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 415



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 480 PP-SYQICFIP 489


>DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  107 bits (256), Expect = 1e-22
 Identities = 95/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSIS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID +    R   + D++H+PYT A I E  R+    P+ V H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDMIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  107 bits (256), Expect = 1e-22
 Identities = 104/399 (26%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYESVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 415



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 480 PP-SYQICFIP 489


>M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.
          Length = 443

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416


>BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  106 bits (255), Expect = 2e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.
          Length = 497

 Score =  106 bits (254), Expect = 2e-22
 Identities = 95/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ + H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.
          Length = 462

 Score =  106 bits (254), Expect = 2e-22
 Identities = 104/399 (26%), Positives = 176/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 3   PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 61

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 62  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE-- 119

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L+  L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 120 ----EAHCLVDELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 172

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V + + +LD  
Sbjct: 173 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL-TRSYIREK-VREHQASLDVN 230

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 231 NP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 289

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 290 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 349

Query: 393 GYGIEKGTVVF-INNYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT +  +   VL++ +++   P  FDP  FL+K
Sbjct: 350 NYLIPKGTTIMALLTSVLHDDKEF-PNPNIFDPGHFLDK 387



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 392 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 451

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 452 PP-SYQICFIP 461


>M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.
          Length = 497

 Score =  106 bits (254), Expect = 2e-22
 Identities = 95/402 (23%), Positives = 172/402 (42%), Gaps = 24/402 (5%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   A RP       L  G R+  + L  +                    T  +  
Sbjct: 91  LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IG--TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G  ++  + + E         + S        +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
             D   P +D  +  L  +       E    D N  I + + F  G  +    +   L  
Sbjct: 261 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATE 387
           +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ + H+ + 
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSR 380

Query: 388 NANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 433 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468


>AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 variant protein.
          Length = 490

 Score =  105 bits (252), Expect = 4e-22
 Identities = 103/403 (25%), Positives = 180/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G    GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFFGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KGT +  +   VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGTTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoquine
           4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
           cds. ).
          Length = 500

 Score =  105 bits (251), Expect = 5e-22
 Identities = 101/406 (24%), Positives = 172/406 (42%), Gaps = 29/406 (7%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R +PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYSPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSL------ALCDWSXXXXXXXXXXXXHCGPKQH 154
           +   G   A RP       L  G R+         AL                  GP Q 
Sbjct: 91  MVTRGEDTADRPPVPITQILGFGPRSQGKQRGVPGALWARVARAEALLRLHLAQLGPGQE 150

Query: 155 TDSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDED 214
             + A     G      L Q L+    R +  +D      K+  N+ ++  C  RF+ +D
Sbjct: 151 V-AGAVGDRGGRLPLCRLRQPLRR-PFRPNGLLD------KAVSNVIASLTCGRRFEYDD 202

Query: 215 LEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE--- 271
             F +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   
Sbjct: 203 PRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL--HIPALAGKVLRFQKAFLTQLDELLT 259

Query: 272 QREINLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSVGNLVML 325
           +  +  D   P +D  +  L  +       E    D N  I + + F  G  +    +  
Sbjct: 260 EHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAW 319

Query: 326 CLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPH 383
            L  +   P+V R+++QEID V    R   + D++H+PYT A I E  R+    P+ V H
Sbjct: 320 GLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTH 379

Query: 384 VATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           + + +  + G+ I KGT +  N   +   E  W +P +F P  FL+
Sbjct: 380 MTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 425



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 436 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 471


>L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18
           protein.
          Length = 490

 Score =  105 bits (251), Expect = 5e-22
 Identities = 103/403 (25%), Positives = 181/403 (44%), Gaps = 26/403 (6%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L  +G   +GR  F    K+  G          W                 K+  +   +
Sbjct: 87  LIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQ 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDAS-IDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
                  E+  L++ L+    +++AS  D   IL  +  N+  + +   RFD +D  F  
Sbjct: 147 ------EEARCLVEELR----KTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLN 196

Query: 220 IVDHFDEIFWEINQGY--AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +++ F+E    ++  +    +  P L  +      K++     I+S++L RI E +E +L
Sbjct: 197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQE-SL 255

Query: 278 DTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVA 331
           D  +  +DF+D  L  + ++    ++     ++I  + D  G G  +    +   L  + 
Sbjct: 256 DMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLL 314

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENA 389
           + PEV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T + 
Sbjct: 315 KYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDV 374

Query: 390 NISGYGIEKG-TVVFINNYVLNNSEQYWSEPEKFDPSRFLEKT 431
               Y I KG T++     VL+N +++   PE FDP  FL+K+
Sbjct: 375 KFKNYLIPKGMTIITSLTSVLHNDKEF-PNPEMFDPGHFLDKS 416



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  105 bits (251), Expect = 5e-22
 Identities = 105/405 (25%), Positives = 183/405 (45%), Gaps = 39/405 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDR----NNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHA 159
             +  +GR D   FH     DR    NN  A   W             +   KQ  +S  
Sbjct: 93  YKDEFSGRGDLPAFHA--HRDRGIIFNNGPA---WKDIRRFSLTTLRNYGMGKQGNES-- 145

Query: 160 RIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQK 219
           RI     F        L+ L        D   ++  +  N+ ++ +    FD  D +F +
Sbjct: 146 RIQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 198

Query: 220 IVDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
           ++  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +
Sbjct: 199 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-S 256

Query: 277 LDTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTA 329
           LD   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  
Sbjct: 257 LDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLI 314

Query: 330 VARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATE 387
           + + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT 
Sbjct: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 374

Query: 388 NANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
           +    GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +  +  F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARTELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1
           protein.
          Length = 493

 Score =  104 bits (250), Expect = 7e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKAIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrome
           P450IIE1 (ethanol-inducible) gene, complete cds. ).
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrome
           P-450j mRNA, complete cds. ).
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLADCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLCVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVREIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 34  PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 93  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 146

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 147 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 257

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 258 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 315

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 417



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 484

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 485 YKLCVIPR 492


>AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1
           protein.
          Length = 495

 Score =  104 bits (249), Expect = 9e-22
 Identities = 124/477 (25%), Positives = 206/477 (43%), Gaps = 59/477 (12%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP    I+G+L LL   +    + T+LSK+YG +++V LG    VV++    ++E L  
Sbjct: 32  PGPRPLSILGNLLLLCSQDM-LTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVD 90

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR D+  F     G+     +   W                 K+  +   RI  
Sbjct: 91  QGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEE--RILE 148

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
            G+F   EL +T            D   +L +S  N+  + +   RFD +D     I+  
Sbjct: 149 EGSFLLAELRKT-------EGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRL 201

Query: 224 FDEIFWEINQ--GYAVDFL----PWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
            ++ F  ++   G   D L    P L  +     +++    + +R  I +  V   + +L
Sbjct: 202 INDNFQIMSSPWGELYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLI-AHSVHDHQASL 260

Query: 278 DTEAPEKDFLDGLLRVL---HEDPT--MDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVA 331
           D  +P +DF+   L  +    EDP      +T++    + L GG  +V   +     A+ 
Sbjct: 261 DPRSP-RDFIHCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALM 319

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENA 389
           + P+V  ++++EID V    R   L DR+ +PYT+A I E  R+A   P+ +PH  T + 
Sbjct: 320 KYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDT 379

Query: 390 NISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLESDS 449
              G+ I KGT V      L N+  Y       DPS+FL      T +    +  L+++ 
Sbjct: 380 AFRGFLIPKGTDVI----TLLNTVHY-------DPSQFL------TPQEFNPEHFLDANQ 422

Query: 450 ERAPVGKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
                          S KK+ P F+PFS G+R C+G+++     F     I+QSF +
Sbjct: 423 ---------------SFKKS-PAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSL 463


>AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 462

 Score =  104 bits (249), Expect = 9e-22
 Identities = 101/404 (25%), Positives = 182/404 (45%), Gaps = 37/404 (9%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG+L  L     P ++FT L++++G +F++ +GS   VV++    ++E L  
Sbjct: 3   PGPFPLPIIGNLFQLELKNIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 61

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSXXXXXXXXXXXXHCGPKQHTDSHAR 160
             +  +GR D   FH      R+  +   +   W             +   KQ  +S  R
Sbjct: 62  YKDEFSGRGDLPAFH----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES--R 115

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKI 220
           I     F        L+ L        D   ++  +  N+ ++ +    FD  D +F ++
Sbjct: 116 IQREAHF-------LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 168

Query: 221 VDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL 277
           +  F+E F  ++  +     +F  +L      H + + N ++ ++ ++  R+ E  + +L
Sbjct: 169 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQ-SL 226

Query: 278 DTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           D   P +D  D LL  + ++        TMD  T+  + + F  G  +    +   L  +
Sbjct: 227 DPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-VADLFFAGTETTSTTLRYGLLIL 284

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATEN 388
            + PE+  K+ +EID V    R   + DR  +PY +A + E  R+ +     +PH AT +
Sbjct: 285 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 344

Query: 389 ANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDPSRFLEK 430
               GY I KGTVV   +++ + +N E  + +PEKF P  FL +
Sbjct: 345 TIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKPEHFLNE 386



 Score = 33.9 bits (74), Expect = 1.5
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 472 HFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNT 527
           +F PFS GKR C G+ +     F +   I+Q F +  + +  D+   P  +    +P   
Sbjct: 395 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR- 453

Query: 528 YKMHLIPR 535
           YK+ +IPR
Sbjct: 454 YKLCVIPR 461


>AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13
           variant 5 protein.
          Length = 494

 Score =  103 bits (247), Expect = 2e-21
 Identities = 101/402 (25%), Positives = 171/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI+ L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIEALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family 1
           subfamily A polypeptide 1 protein.
          Length = 483

 Score =  102 bits (245), Expect = 3e-21
 Identities = 91/358 (25%), Positives = 159/358 (44%), Gaps = 20/358 (5%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L   PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LENPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCD---WSX-XXXXXXXXXXXHCGPKQHT 155
            L + G+   GRPD   F  L +  ++ S +      W+                    +
Sbjct: 95  ALVRQGDDFKGRPDLYTF-TLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153

Query: 156 DSHARIGTVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDL 215
            +   +    + E+  LI TL+ L +      +    ++ S  N+        R+D    
Sbjct: 154 STSCYLEEHVSKEAEVLISTLQELMA-GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQ 212

Query: 216 EFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
           E   +V+  +     +  G   DF+P L       +    + ++   SF + ++V++   
Sbjct: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF-MQKMVKEHYK 271

Query: 276 NLDTEAPEKDFLDGLL-----RVLHEDPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCL 327
             + +   +D  D L+     + L E+  +   D   I  +L+ F  G  +V   +   L
Sbjct: 272 TFE-KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 328 TAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPH 383
             +  +P V RKI++E+D V    R   L+DRSH PY EA ILE  R++S  P  +PH
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHPPYMEAFILETFRHSSFVPFTIPH 388


>AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13
           variant 3 protein.
          Length = 494

 Score =  102 bits (245), Expect = 3e-21
 Identities = 101/402 (25%), Positives = 170/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13
           variant 2 protein.
          Length = 494

 Score =  102 bits (245), Expect = 3e-21
 Identities = 101/402 (25%), Positives = 170/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13
           variant 1 protein.
          Length = 494

 Score =  102 bits (245), Expect = 3e-21
 Identities = 101/402 (25%), Positives = 170/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13
           protein.
          Length = 494

 Score =  102 bits (245), Expect = 3e-21
 Identities = 101/402 (25%), Positives = 170/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.
          Length = 477

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 18  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 76

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 77  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 133

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 134 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 187

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 188 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 245

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 246 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 304

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 305 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 364

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 365 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 402



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 407 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 445


>D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.
          Length = 487

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 28  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 86

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 87  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 143

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 144 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 197

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 198 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 255

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 256 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 314

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 315 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 374

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 375 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 412



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 417 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 455


>BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 31  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 146

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 147 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 258

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 259 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 378 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 415



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 31  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 146

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 147 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 258

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 259 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 378 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 415



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 31  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 146

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 147 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 258

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 259 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 378 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 415



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  102 bits (244), Expect = 4e-21
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 31  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 146

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 147 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 258

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 259 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  RY       +PH  T +    
Sbjct: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 378 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 415



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13
           variant 6 protein.
          Length = 494

 Score =  101 bits (242), Expect = 6e-21
 Identities = 100/402 (24%), Positives = 170/402 (42%), Gaps = 32/402 (7%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 219 KIVDHF--DEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREIN 276
            ++        F   + G   +    +        ++     Q +  FI  + VE  +  
Sbjct: 200 SLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRT 258

Query: 277 LDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAV 330
           LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +      +
Sbjct: 259 LDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLL 317

Query: 331 ARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATEN 388
            + PE+  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   ++
Sbjct: 318 MKHPELEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKD 377

Query: 389 ANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                + + KGT VF     +    +++S P  F+P  FL+K
Sbjct: 378 TKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family 2,
           subfamily W, polypeptide 1 protein.
          Length = 490

 Score = 99.1 bits (236), Expect = 3e-20
 Identities = 98/400 (24%), Positives = 173/400 (43%), Gaps = 28/400 (7%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP   P++G+LHLL   +   ++  ELS++YG +F+V LG    VV+     ++E 
Sbjct: 30  RWPPGPRPLPLVGNLHLLRLSQQD-RSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEA 88

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           L   G  +A RP    F  +  G      +   W                       H+ 
Sbjct: 89  LAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRAL------------HS- 135

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLK---PILMKSAMNMFSNYMCSVRFDDEDLEF 217
           +G      + +++Q LK L+ + D          +L  +  N+    +   RFD  D  F
Sbjct: 136 LGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVF 195

Query: 218 QKIVDHFDEIFWEINQ-GYAV-DFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREI 275
             ++   DE+   +   G  + +  PWL    + H   L    +++R+ IL  ++E R  
Sbjct: 196 VSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK-IEEVRA-ILRTLLEARRP 253

Query: 276 NLDTEAPEKDFLDGLLRVLH-EDPT---MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVA 331
           ++    P   ++D L++    +DP     + N +   L+  + G  +    +      + 
Sbjct: 254 HVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMG 313

Query: 332 RDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPIVPHVATENAN 390
           R P+V  ++++E+D V    R   L D+  LPYT A + E  R+ +  P VP     +  
Sbjct: 314 RHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQ 373

Query: 391 ISGYGIEKGT-VVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           + G+ + KGT V+ +   VL +  Q W  P +F+P  FL+
Sbjct: 374 LGGFLLPKGTPVIPLLTSVLLDETQ-WQTPGQFNPGHFLD 412



 Score = 37.5 bits (83), Expect = 0.12
 Identities = 12/34 (35%), Positives = 23/34 (67%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           F+PFS G+R C+G+ +  +  F +FA ++Q + +
Sbjct: 423 FLPFSAGRRVCVGERLARTELFLLFAGLLQRYRL 456


>M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score = 98.7 bits (235), Expect = 5e-20
 Identities = 99/399 (24%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 26  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 84

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 85  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 141

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 142 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 195

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 196 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 253

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 254 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 312

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  R        +PH  T +    
Sbjct: 313 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFR 372

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 373 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 410



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 415 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453


>M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score = 98.7 bits (235), Expect = 5e-20
 Identities = 99/399 (24%), Positives = 178/399 (44%), Gaps = 26/399 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++  +G  +   ++ T LSK YG +F++  G    VV++    ++E L  
Sbjct: 26  PGPTPLPVIGNILQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 84

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR  F    +   G          W                 K+  +   +   
Sbjct: 85  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ--- 141

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+       +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 142 ---EEARCLVEELR---KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 195

Query: 224 FDEIFWEINQGY---AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
            +E    ++  +     +F P +  F   H + L N +  ++S+IL ++ E +E ++D  
Sbjct: 196 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQE-SMDMN 253

Query: 281 APEKDFLD-GLLRVLHEDPTMDRNTIIFMLED-----FLGGHSSVGNLVMLCLTAVARDP 334
            P+ DF+D  L+++  E         I  LE+     F  G  +    +   L  + + P
Sbjct: 254 NPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 312

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANIS 392
           EV  K+++EI+ V    R   + DRSH+PYT+A + E  R        +PH  T +    
Sbjct: 313 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFR 372

Query: 393 GYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
            Y I KGT + I+   VL++++++   PE FDP  FL++
Sbjct: 373 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDE 410



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 415 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453


>J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.
          Length = 491

 Score = 98.3 bits (234), Expect = 6e-20
 Identities = 117/472 (24%), Positives = 202/472 (42%), Gaps = 53/472 (11%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP    I+G+L LL   +    + T+LSK+YG +++V LG    VV++    ++E L  
Sbjct: 32  PGPRPLSILGNLLLLCSQDM-LTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVD 90

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +GR D+  F     G+     +   W                 K+  +   RI  
Sbjct: 91  QGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEE--RILE 148

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
            G+F   ++ +T            D   +L +S  N+  + +   RFD +D     I+  
Sbjct: 149 EGSFLLADVRKT-------EGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRL 201

Query: 224 FDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDI-RSFILSRIVEQREINLDTEAP 282
            ++ F  ++  +  +    L P +   ++ +    Q I ++F   R +    ++    + 
Sbjct: 202 INDNFQIMSSPWG-ELYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASS 260

Query: 283 EKDFLDGLLRVL---HEDPT--MDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEV 336
            +DF+   L  +    EDP      +T++    + L GG  +V   +     A+ + P+V
Sbjct: 261 PRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKV 320

Query: 337 GRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGY 394
             ++++EID V    R   L DR+ +PYT+A I E  R+A   P+ +PH  T +    G+
Sbjct: 321 QARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGF 380

Query: 395 GIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRRNSQCDSGLESDSERAPV 454
            I KGT V      L N+  Y       DPS+FL      T +    +  L+++      
Sbjct: 381 LIPKGTDVI----TLLNTVHY-------DPSQFL------TPQEFNPEHFLDANQ----- 418

Query: 455 GKPDVEREMLSVKKNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
                     S KK+ P F+PFS G+R C+G+ +     F     I+QSF +
Sbjct: 419 ----------SFKKS-PAFMPFSAGRRLCLGELLARMELFLYLTAILQSFSL 459


>BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family 2,
           subfamily S, polypeptide 1 protein.
          Length = 504

 Score = 98.3 bits (234), Expect = 6e-20
 Identities = 98/398 (24%), Positives = 167/398 (41%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGS-ADCVVVNNLSLIREVLN 102
           PGP   P++G+L  L    + +     LSKKYG +F++ LG     VV+     +RE L 
Sbjct: 34  PGPTPLPLLGNLLQLRPG-ALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92

Query: 103 QNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIG 162
                 +GR         F G          W                 K+  +   +  
Sbjct: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQA- 151

Query: 163 TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVD 222
                E+  L++T +G   R     D   +L ++  N+  + +  +RF  ED EFQ +V 
Sbjct: 152 -----EARCLVETFQGTEGRP---FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVR 203

Query: 223 HFDEIFWEINQ--GYAVDFLPW-LAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                   ++   G   +   W L P    H + L + S  + +F + R V+Q + NLD 
Sbjct: 204 AAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTV-RQVQQHQGNLDA 261

Query: 280 EAPEKDFLDG-LLRVLHEDPT-----MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
             P +D +D  LL++  E+        ++N ++ ++     G  +V   V   L  + + 
Sbjct: 262 SGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKY 321

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR-YASSPI-VPHVATENANI 391
           P V + +R+E++      +   L DR+ LPYT+A + E  R  A  P+ +P         
Sbjct: 322 PHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRF 381

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
            GY + +GT VF     + +    +  PE+F+P RFL+
Sbjct: 382 RGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 14/34 (41%), Positives = 23/34 (67%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           F+PFS+GKR C+G+ +  +  F  F  I+Q+F +
Sbjct: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463


>AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.
          Length = 504

 Score = 98.3 bits (234), Expect = 6e-20
 Identities = 98/398 (24%), Positives = 167/398 (41%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGS-ADCVVVNNLSLIREVLN 102
           PGP   P++G+L  L    + +     LSKKYG +F++ LG     VV+     +RE L 
Sbjct: 34  PGPTPLPLLGNLLQLRPG-ALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92

Query: 103 QNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIG 162
                 +GR         F G          W                 K+  +   +  
Sbjct: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQA- 151

Query: 163 TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVD 222
                E+  L++T +G   R     D   +L ++  N+  + +  +RF  ED EFQ +V 
Sbjct: 152 -----EARCLVETFQGTEGRP---FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVR 203

Query: 223 HFDEIFWEINQ--GYAVDFLPW-LAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                   ++   G   +   W L P    H + L + S  + +F + R V+Q + NLD 
Sbjct: 204 AAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTV-RQVQQHQGNLDA 261

Query: 280 EAPEKDFLDG-LLRVLHEDPT-----MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
             P +D +D  LL++  E+        ++N ++ ++     G  +V   V   L  + + 
Sbjct: 262 SGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKY 321

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR-YASSPI-VPHVATENANI 391
           P V + +R+E++      +   L DR+ LPYT+A + E  R  A  P+ +P         
Sbjct: 322 PHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRF 381

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
            GY + +GT VF     + +    +  PE+F+P RFL+
Sbjct: 382 RGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 14/34 (41%), Positives = 23/34 (67%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           F+PFS+GKR C+G+ +  +  F  F  I+Q+F +
Sbjct: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463


>AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens
           cDNA FLJ14699 fis, clone NT2RP2006571, moderately
           similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
          Length = 564

 Score = 98.3 bits (234), Expect = 6e-20
 Identities = 98/398 (24%), Positives = 167/398 (41%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGS-ADCVVVNNLSLIREVLN 102
           PGP   P++G+L  L    + +     LSKKYG +F++ LG     VV+     +RE L 
Sbjct: 34  PGPTPLPLLGNLLQLRPG-ALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92

Query: 103 QNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIG 162
                 +GR         F G          W                 K+  +   +  
Sbjct: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQA- 151

Query: 163 TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVD 222
                E+  L++T +G   R     D   +L ++  N+  + +  +RF  ED EFQ +V 
Sbjct: 152 -----EARCLVETFQGTEGRP---FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVR 203

Query: 223 HFDEIFWEINQ--GYAVDFLPW-LAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                   ++   G   +   W L P    H + L + S  + +F + R V+Q + NLD 
Sbjct: 204 AAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTV-RQVQQHQGNLDA 261

Query: 280 EAPEKDFLDG-LLRVLHEDPT-----MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
             P +D +D  LL++  E+        ++N ++ ++     G  +V   V   L  + + 
Sbjct: 262 SGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKY 321

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR-YASSPI-VPHVATENANI 391
           P V + +R+E++      +   L DR+ LPYT+A + E  R  A  P+ +P         
Sbjct: 322 PHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRF 381

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
            GY + +GT VF     + +    +  PE+F+P RFL+
Sbjct: 382 RGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 14/34 (41%), Positives = 23/34 (67%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           F+PFS+GKR C+G+ +  +  F  F  I+Q+F +
Sbjct: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463


>AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1
           protein.
          Length = 504

 Score = 98.3 bits (234), Expect = 6e-20
 Identities = 98/398 (24%), Positives = 167/398 (41%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGS-ADCVVVNNLSLIREVLN 102
           PGP   P++G+L  L    + +     LSKKYG +F++ LG     VV+     +RE L 
Sbjct: 34  PGPTPLPLLGNLLQLRPG-ALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92

Query: 103 QNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIG 162
                 +GR         F G          W                 K+  +   +  
Sbjct: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQA- 151

Query: 163 TVGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVD 222
                E+  L++T +G   R     D   +L ++  N+  + +  +RF  ED EFQ +V 
Sbjct: 152 -----EARCLVETFQGTEGRP---FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVR 203

Query: 223 HFDEIFWEINQ--GYAVDFLPW-LAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                   ++   G   +   W L P    H + L + S  + +F + R V+Q + NLD 
Sbjct: 204 AAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTV-RQVQQHQGNLDA 261

Query: 280 EAPEKDFLDG-LLRVLHEDPT-----MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
             P +D +D  LL++  E+        ++N ++ ++     G  +V   V   L  + + 
Sbjct: 262 SGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKY 321

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR-YASSPI-VPHVATENANI 391
           P V + +R+E++      +   L DR+ LPYT+A + E  R  A  P+ +P         
Sbjct: 322 PHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRF 381

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
            GY + +GT VF     + +    +  PE+F+P RFL+
Sbjct: 382 RGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 14/34 (41%), Positives = 23/34 (67%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           F+PFS+GKR C+G+ +  +  F  F  I+Q+F +
Sbjct: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463


>M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score = 96.7 bits (230), Expect = 2e-19
 Identities = 97/397 (24%), Positives = 168/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 96.7 bits (230), Expect = 2e-19
 Identities = 97/397 (24%), Positives = 168/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPRHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 96.7 bits (230), Expect = 2e-19
 Identities = 97/397 (24%), Positives = 168/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 96.7 bits (230), Expect = 2e-19
 Identities = 97/397 (24%), Positives = 168/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6
           protein.
          Length = 494

 Score = 96.7 bits (230), Expect = 2e-19
 Identities = 97/397 (24%), Positives = 168/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>M12079-1|AAA52152.1|  191|Homo sapiens POR protein.
          Length = 191

 Score = 96.3 bits (229), Expect = 2e-19
 Identities = 50/130 (38%), Positives = 74/130 (56%), Gaps = 2/130 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 10  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 69

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSE 418
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ ++ W  
Sbjct: 70  HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 129

Query: 419 PEKFDPSRFL 428
           P +F P RFL
Sbjct: 130 PSEFLPERFL 139


>AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1
           variant protein.
          Length = 484

 Score = 96.3 bits (229), Expect = 2e-19
 Identities = 50/130 (38%), Positives = 74/130 (56%), Gaps = 2/130 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 276 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 335

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSE 418
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ ++ W  
Sbjct: 336 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 395

Query: 419 PEKFDPSRFL 428
           P +F P RFL
Sbjct: 396 PSEFLPERFL 405



 Score = 66.5 bits (155), Expect = 2e-10
 Identities = 30/78 (38%), Positives = 48/78 (61%), Gaps = 2/78 (2%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRF 117
            L + G+   GRPD   F
Sbjct: 95  ALVRQGDDFKGRPDLYTF 112


>AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 251

 Score = 96.3 bits (229), Expect = 2e-19
 Identities = 50/130 (38%), Positives = 74/130 (56%), Gaps = 2/130 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 43  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 102

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSE 418
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ ++ W  
Sbjct: 103 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 162

Query: 419 PEKFDPSRFL 428
           P +F P RFL
Sbjct: 163 PSEFLPERFL 172


>AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 175

 Score = 96.3 bits (229), Expect = 2e-19
 Identities = 50/130 (38%), Positives = 74/130 (56%), Gaps = 2/130 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 43  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 102

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSE 418
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ ++ W  
Sbjct: 103 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 162

Query: 419 PEKFDPSRFL 428
           P +F P RFL
Sbjct: 163 PSEFLPERFL 172


>X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for
           cytochrome P-450IIA. ).
          Length = 489

 Score = 95.9 bits (228), Expect = 3e-19
 Identities = 96/397 (24%), Positives = 169/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 30  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 88

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 89  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 146

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI  L+G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 147 EAGF----LIDALRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 199

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE ++  LD  +
Sbjct: 200 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHKQRTLDPNS 258

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 259 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 317

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  ++ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 318 VEAQVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 377

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 378 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 414



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 424 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 482

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 483 TMSFLPR 489


>U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 95.9 bits (228), Expect = 3e-19
 Identities = 100/404 (24%), Positives = 170/404 (42%), Gaps = 36/404 (8%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     ++E L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  LF G     +A  +                G          +G 
Sbjct: 94  QAEEFSGRGEQATFDWLFKG---YGVAFSNGERAKQLRRFSIATLRG--------FGVGK 142

Query: 164 VGTFESVE-----LIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEF- 217
            G  E ++     LI  L+G      A+ID    L ++  N+ S+ +   RFD ED EF 
Sbjct: 143 RGIEERIQEEAGFLIDALRGTHG---ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFL 199

Query: 218 ---QKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQRE 274
              + ++  F   F   + G   +    +        ++     Q +  FI  + VE  +
Sbjct: 200 SLLRMMLGRFQ--FTGTSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQ 256

Query: 275 INLDTEAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLT 328
             LD  +P +DF+D  L+R+  E+  P  +   +N ++  L  F  G  +V   +     
Sbjct: 257 RTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFL 315

Query: 329 AVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVAT 386
            + + PEV  K+ +EID V    R     DR+ +PYTEA I E  R+    P+ + H   
Sbjct: 316 LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVN 375

Query: 387 ENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           ++     + + KGT VF          +++S P+   P  FL++
Sbjct: 376 KDTKFRDFFLPKGTEVFPMLGSELRDPRFFSNPQDCSPQHFLDE 419



 Score = 44.4 bits (100), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  IMQ+F     ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mRNA
           for P-450 IIA4 protein. ).
          Length = 494

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 96/397 (24%), Positives = 167/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI   +G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDAHRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>DQ359216-1|ABC95161.1|  347|Homo sapiens dioxin-inducible
           cytochrome P450 protein.
          Length = 347

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 69/258 (26%), Positives = 123/258 (47%), Gaps = 13/258 (5%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAGDRNNSLA-LCDWSXXXXXXXXXXXXHCGPKQHTDS 157
           + L Q G+  A RP F  F ++ +G R+ +     +              +   +Q    
Sbjct: 105 QALVQQGSAFADRPAFASF-RVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSR 163

Query: 158 HARIGTVGTFESVELIQTL-KGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLE 216
               G V   E+ EL+  L +G  S   A +D +P+ + +  N+ S      R+  +D E
Sbjct: 164 QVLEGHV-LSEARELVALLVRG--SADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPE 220

Query: 217 FQKIVDHFDEIFWEINQGYAVDFLPWLAPF---YKKHMEKLSNWSQDIRSFILSRIVEQR 273
           F++++ H +E    +  G  VD +PWL  F    +    +    +++  +FIL + +   
Sbjct: 221 FRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHC 280

Query: 274 EINLDTEAPEKDFLDGLL 291
           E +L   A  +D +D  +
Sbjct: 281 E-SLRPGAAPRDKMDAFI 297


>BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 96/397 (24%), Positives = 167/397 (42%), Gaps = 22/397 (5%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G      +  + +              G  +      RI  
Sbjct: 94  QAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQE 151

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
              F    LI   +G      A+ID    L ++  N+ S+ +   RFD +D EF  ++  
Sbjct: 152 EAGF----LIDAHRGT---GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 204

Query: 224 FDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
              IF     + G   +    +        ++     Q +  FI  + VE  +  LD  +
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNS 263

Query: 282 PEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L+R+  E+  P  +   +N ++  L  F+GG  +V   +      + + PE
Sbjct: 264 P-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPE 322

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISG 393
           V  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++     
Sbjct: 323 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 382

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
           + + KGT V+     +     ++S P+ F+P  FL +
Sbjct: 383 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 94/398 (23%), Positives = 174/398 (43%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++ L    +   ++ T LSK YG +F++  G    VV++   +++E L  
Sbjct: 31  PGPTPLPVIGNI-LQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +G     R H   A   N    +  +S                +        I  
Sbjct: 90  LGEEFSG-----RGHFPLAERANRGFGIV-FSNGKRWKEIRRFSLMTLRNFGMGKRSIED 143

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 144 RVQEEARCLVEELRKTKA---SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGYA--VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
            +E    ++  +    +  P +  ++     KL      + S IL ++ E +E ++D   
Sbjct: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE-SMDINN 259

Query: 282 PEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L  + ++    ++      ++    D LG G  +    +   L  + + PE
Sbjct: 260 P-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANISG 393
           V  K+++EI+ V    R   + DR H+PYT+A + E  RY       +PH  T +     
Sbjct: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378

Query: 394 YGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
           Y I KGT +  +   VL++++++   PE FDP  FL++
Sbjct: 379 YLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDE 415



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458


>AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 94/398 (23%), Positives = 174/398 (43%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++ L    +   ++ T LSK YG +F++  G    VV++   +++E L  
Sbjct: 31  PGPTPLPVIGNI-LQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +G     R H   A   N    +  +S                +        I  
Sbjct: 90  LGEEFSG-----RGHFPLAERANRGFGIV-FSNGKRWKEIRRFSLMTLRNFGMGKRSIED 143

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 144 RVQEEARCLVEELRKTKA---SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGYA--VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
            +E    ++  +    +  P +  ++     KL      + S IL ++ E +E ++D   
Sbjct: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE-SMDINN 259

Query: 282 PEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L  + ++    ++      ++    D LG G  +    +   L  + + PE
Sbjct: 260 P-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANISG 393
           V  K+++EI+ V    R   + DR H+PYT+A + E  RY       +PH  T +     
Sbjct: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378

Query: 394 YGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
           Y I KGT +  +   VL++++++   PE FDP  FL++
Sbjct: 379 YLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDE 415



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458


>AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 94/398 (23%), Positives = 174/398 (43%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++ L    +   ++ T LSK YG +F++  G    VV++   +++E L  
Sbjct: 31  PGPTPLPVIGNI-LQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +G     R H   A   N    +  +S                +        I  
Sbjct: 90  LGEEFSG-----RGHFPLAERANRGFGIV-FSNGKRWKEIRRFSLMTLRNFGMGKRSIED 143

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 144 RVQEEARCLVEELRKTKA---SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGYA--VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
            +E    ++  +    +  P +  ++     KL      + S IL ++ E +E ++D   
Sbjct: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE-SMDINN 259

Query: 282 PEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L  + ++    ++      ++    D LG G  +    +   L  + + PE
Sbjct: 260 P-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANISG 393
           V  K+++EI+ V    R   + DR H+PYT+A + E  RY       +PH  T +     
Sbjct: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378

Query: 394 YGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
           Y I KGT +  +   VL++++++   PE FDP  FL++
Sbjct: 379 YLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDE 415



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458


>M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score = 93.5 bits (222), Expect = 2e-18
 Identities = 94/398 (23%), Positives = 174/398 (43%), Gaps = 24/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P+IG++ L    +   ++ T LSK YG +F++  G    VV++   +++E L  
Sbjct: 31  PGPTPLPVIGNI-LQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
            G   +G     R H   A   N    +  +S                +        I  
Sbjct: 90  LGEEFSG-----RGHFPLAERANRGFGIV-FSNGKRWKEIRRFSLMTLRNFGMGKRSIED 143

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D +F  +++ 
Sbjct: 144 RVQEEARCLVEELRKTKA---SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200

Query: 224 FDEIFWEINQGYA--VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEA 281
            +E    ++  +    +  P +  ++     KL      + S IL ++ E +E ++D   
Sbjct: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE-SMDINN 259

Query: 282 PEKDFLDGLLRVLHEDPTMDRN-----TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPE 335
           P +DF+D  L  + ++    ++      ++    D LG G  +    +   L  + + PE
Sbjct: 260 P-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318

Query: 336 VGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS--SPIVPHVATENANISG 393
           V  K+++EI+ V    R   + DR H+PYT+A + E  RY       +PH  T +     
Sbjct: 319 VTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378

Query: 394 YGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRFLEK 430
           Y I KGT +  +   VL++++++   PE FDP  FL++
Sbjct: 379 YLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDE 415



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score = 92.7 bits (220), Expect = 3e-18
 Identities = 96/398 (24%), Positives = 165/398 (41%), Gaps = 26/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E    +  + S+ YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEHICDSIMKFSECYGPVFTIHLGPRRAVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G     +A  +                     T     +G 
Sbjct: 94  QAEEFSGRGEQATFDWVFKG---YGVAFSNGERAKQLLRFAIA--------TLRDFGVGK 142

Query: 164 VGTFESVELIQ--TLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
            G  E ++      ++ + S   A+ID    L ++  N+ S+ +   RFD ED EF  ++
Sbjct: 143 RGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL 202

Query: 222 DHFDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                IF     + G   +    +        ++     Q +  FI  + VE  +  LD 
Sbjct: 203 SVMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKK-VEHNQRTLDP 261

Query: 280 EAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
            +P +DF+D  L+R+  E+  P  +   +N ++  L  F+ G  +V   +      + + 
Sbjct: 262 NSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKH 320

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANI 391
           PEV  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++   
Sbjct: 321 PEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF 380

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
             + + KGT VF     +     ++S P+ F+P  FL+
Sbjct: 381 RDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418



 Score = 44.8 bits (101), Expect = 8e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score = 92.3 bits (219), Expect = 4e-18
 Identities = 95/398 (23%), Positives = 163/398 (40%), Gaps = 26/398 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E    +  + S+ YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G     +A  +                     T     +G 
Sbjct: 94  QAEEFSGRGEQATFDWVFKG---YGVAFSNGERAKQLLRFAIA--------TLRDFGVGK 142

Query: 164 VGTFESVELIQ--TLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
            G  E ++      ++ + S   A+ID    L ++  N+ S+ +   RFD ED EF  ++
Sbjct: 143 RGIEERIQEESGFLIEAIRSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL 202

Query: 222 DHFDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                IF     + G   +    +        ++     Q +  FI  + VE  +  LD 
Sbjct: 203 SMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKK-VEHNQRTLDP 261

Query: 280 EAPEKDFLDGLLRVLHED---PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
            +P+ DF+D  L  + E+   P  +   +N ++  L  F+ G  +V   +      + + 
Sbjct: 262 NSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKH 320

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANI 391
           PEV  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++   
Sbjct: 321 PEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF 380

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
             + + KGT VF     +     ++S P+ F+P  FL+
Sbjct: 381 RDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418



 Score = 42.7 bits (96), Expect = 0.003
 Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +      ++I+   +      +P+N Y
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSSKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxylase
           mutant allele variant protein.
          Length = 566

 Score = 91.9 bits (218), Expect = 5e-18
 Identities = 86/373 (23%), Positives = 155/373 (41%), Gaps = 24/373 (6%)

Query: 70  ELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRPDFLRFHKLFAGDRNNSL 129
           +L +++GD+FS++L     VV+N L+ +RE +   G   A RP       L  G R+  +
Sbjct: 130 QLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGV 189

Query: 130 ALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIG--TVGTFESVELIQTLKGLTSRSDASI 187
            L  +                    T  +  +G  ++  + + E         + SDA  
Sbjct: 190 FLARYGPAWREQRRFSVS-------TLRNLGLGKKSLEQWVTEEAACLCAAFANHSDAPF 242

Query: 188 DLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFY 247
               +      N+ ++  C  RF+ +D  F +++D   E   E   G+  + L  +    
Sbjct: 243 -APTVSWTKPSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL 300

Query: 248 KKHMEKLSNWSQDIRSFILSRIVE---QREINLDTEAPEKDFLDGLLRVLH------EDP 298
             H+  L+      +   L+++ E   +  +  D   P +D  +  L  +       E  
Sbjct: 301 --HIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS 358

Query: 299 TMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTD 358
             D N  I + + F  G  +    +   L  +   P+V R+++QEID V    R   + D
Sbjct: 359 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD 418

Query: 359 RSHLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYW 416
           ++H+PYT A I E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W
Sbjct: 419 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 478

Query: 417 SEPEKFDPSRFLE 429
            +P +F P  FL+
Sbjct: 479 EKPFRFHPEHFLD 491



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 502 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 537


>U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 90.6 bits (215), Expect = 1e-17
 Identities = 96/406 (23%), Positives = 170/406 (41%), Gaps = 27/406 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E  + +  ++S++YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G     +   +                     T     +G 
Sbjct: 94  QAEEFSGRGEQATFDWVFKG---YGVVFSNGERAKQLLRFAIA--------TLRDFGVGK 142

Query: 164 VGTFESVELIQ--TLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
            G  E ++      ++ + S   A+ID    L ++  N+ S+ +   RFD +D EF  ++
Sbjct: 143 RGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 202

Query: 222 DHFDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                IF     + G   +    +        ++     Q +  FI  + VE  +  LD 
Sbjct: 203 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDP 261

Query: 280 EAPEKDFLDG-LLRVLHED--PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
            +P +DF+D  L+R+  E+  P  +   +N ++  L  F+ G  +V   +      + + 
Sbjct: 262 NSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLHYGFLLLMKH 320

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANI 391
           PEV  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++   
Sbjct: 321 PEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF 380

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL-EKTRVRTR 436
             + + KG  VF     +    +++S P  F+P  FL EK + + R
Sbjct: 381 RDFFLPKGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKR 426



 Score = 42.3 bits (95), Expect = 0.004
 Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSI KR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 90.2 bits (214), Expect = 2e-17
 Identities = 98/406 (24%), Positives = 166/406 (40%), Gaps = 27/406 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P IG+ +L    E    +  + S+ YG +F++ LG    VV+     +RE L  
Sbjct: 35  PGPTPLPFIGN-YLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVD 93

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                +GR +   F  +F G     +A  +                     T     +G 
Sbjct: 94  QAEEFSGRGEQATFEWVFKG---YGVAFSNGERAKQLLRFAIA--------TLRDFGVGK 142

Query: 164 VGTFESVELIQ--TLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
            G  E ++      ++ + S   A+ID    L ++  N+ S+ +   RFD ED EF  ++
Sbjct: 143 RGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL 202

Query: 222 DHFDEIFW--EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDT 279
                IF     + G   +    L        ++       +  FI  + VE  +  LD 
Sbjct: 203 SMMLGIFQFTSTSTGQLYEMFSSLMKHLPGPQQQAFKLLLGLEDFIAKK-VEHNQRTLDP 261

Query: 280 EAPEKDFLDGLLRVLHED---PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARD 333
            +P+ DF+D  L  + E+   P  +   +N ++  L  F+ G  +V   +      + + 
Sbjct: 262 NSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKH 320

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANI 391
           PEV  K+ +EID V    R     DR+ +PY EA I E  R+    P+ +     ++   
Sbjct: 321 PEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKF 380

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL-EKTRVRTR 436
             + + KGT VF     +    +++S P  F+P  FL EK + + R
Sbjct: 381 RDFFLPKGTEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKR 426



 Score = 42.3 bits (95), Expect = 0.004
 Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSI KR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 429 FVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN-Y 487

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 488 TMSFLPR 494


>M12078-1|AAA52154.1|  192|Homo sapiens POR protein.
          Length = 192

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 47/127 (37%), Positives = 72/127 (56%), Gaps = 3/127 (2%)

Query: 305 IIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLP 363
           I+ +L D  G G  +V   +   L  +   PE+ RKI++E+D V   +R   L+DR  LP
Sbjct: 13  IVNLLNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLP 72

Query: 364 YTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEK 421
           Y EA ILE  R++S  P  +PH  T +  ++G+ I K   VF+N + +N+  + W +P +
Sbjct: 73  YLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSE 132

Query: 422 FDPSRFL 428
           F P RFL
Sbjct: 133 FRPERFL 139


>X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C
           protein.
          Length = 356

 Score = 89.4 bits (212), Expect = 3e-17
 Identities = 70/244 (28%), Positives = 119/244 (48%), Gaps = 20/244 (8%)

Query: 203 NYMCSV----RFDDEDLEFQKIVDHFDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLS 255
           N +CSV    RFD +D  F  ++  F+E F  +N  +    +  P L   F   H + L 
Sbjct: 42  NVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLK 101

Query: 256 NWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLE 310
           N +   RS+I  + V++ + +LD   P +DF+D  L  + ++    ++      ++    
Sbjct: 102 NVALT-RSYIREK-VKEHQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFTIENLVITAA 158

Query: 311 DFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATI 369
           D LG G  +    +   L  + + PEV  K+++EI+ V    R   + DR H+PYT+A +
Sbjct: 159 DLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV 218

Query: 370 LECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSR 426
            E  RY       +PH  T +     Y I KGT +  +   VL++++++   PE FDP  
Sbjct: 219 HEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRH 277

Query: 427 FLEK 430
           FL++
Sbjct: 278 FLDE 281



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 286 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 324


>M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.
          Length = 370

 Score = 89.4 bits (212), Expect = 3e-17
 Identities = 68/244 (27%), Positives = 122/244 (50%), Gaps = 20/244 (8%)

Query: 203 NYMCSV----RFDDEDLEFQKIVDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLS 255
           N +CS+    RFD +D +F  +++  +E    ++  +     +F   +  F   H + L 
Sbjct: 56  NVICSIIFHKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFSTIIDYFPGSHNKLLK 115

Query: 256 NWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLE 310
           N    ++S++L RI E +E +LD   P +DF+D  L  + ++    ++     ++I  + 
Sbjct: 116 NLLT-LKSYVLERIKEHQE-SLDMNNP-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVT 172

Query: 311 DFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATI 369
           D  G G  +    +   L  + + PEV  K+++EI+ V    R   + DRSH+PYT+A +
Sbjct: 173 DMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRSHMPYTDAVV 232

Query: 370 LECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSR 426
            E  RY       +PH  T +     Y I KGT +  +   VL++++++   PE FDP  
Sbjct: 233 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRH 291

Query: 427 FLEK 430
           FL++
Sbjct: 292 FLDE 295



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 300 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 338


>M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrome
           P-450 1 mRNA, complete cds, clone Hp1-2. ).
          Length = 393

 Score = 89.4 bits (212), Expect = 3e-17
 Identities = 93/366 (25%), Positives = 159/366 (43%), Gaps = 24/366 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   PIIG++  +   +   ++FT  SK YG +F+V  G    VV +    ++E L  
Sbjct: 31  PGPTPLPIIGNMLQIDVKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 89

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           NG   +GR +     ++  G    S     W                 K+  +   +   
Sbjct: 90  NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIEDRVQE-- 147

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  L++ L+   +   +  D   IL  +  N+  + +   RFD +D  F  ++  
Sbjct: 148 ----EAHCLVEELRKTKA---SPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKR 200

Query: 224 FDEIFWEINQGY--AVDFLPWLAP-FYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F+E F  +N  +    +  P L   F   H + L N +   RS+I  + V++ + +LD  
Sbjct: 201 FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT-RSYIREK-VKEHQASLDVN 258

Query: 281 APEKDFLDGLLRVLHEDPTMDR------NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
            P +DF+D  L  + ++    +      N +  + + F+ G  +    +   L  + + P
Sbjct: 259 NP-RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANIS 392
           EV  K+++EID V    R   + DRSH+PYT+A + E  RY+   P  VPH  T +    
Sbjct: 318 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 377

Query: 393 GYGIEK 398
            Y I K
Sbjct: 378 NYLIPK 383


>X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is 3rd
           base in codon) protein.
          Length = 448

 Score = 88.6 bits (210), Expect = 5e-17
 Identities = 90/379 (23%), Positives = 159/379 (41%), Gaps = 21/379 (5%)

Query: 62  ESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRPDFLRFHKLF 121
           E  + +  ++S++YG +F++ LG    VV+     +RE L       +GR +   F  +F
Sbjct: 6   EQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVF 65

Query: 122 AGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVELIQTLKGLTS 181
            G      +  + +              G  +      RI     F    LI  L+G   
Sbjct: 66  KG-YGVVFSNGERAKQLRRFSIATLRDFGVGKR-GIEERIQEEAGF----LIDALRGT-- 117

Query: 182 RSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFW--EINQGYAVDF 239
              A+ID    L ++  N+ S+ +   RFD +D EF  ++     IF     + G   + 
Sbjct: 118 -GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEM 176

Query: 240 LPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG-LLRVLHED- 297
              +        ++     Q +  FI  + VE  +  LD  +P +DF+D  L+R+  E+ 
Sbjct: 177 FSSVMKHLPGPQQQAFQLLQGLEDFIAKK-VEHNQRTLDPNSP-RDFIDSFLIRMQEEEK 234

Query: 298 -PTMD---RNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRP 353
            P  +   +N ++  L  F+GG  +V   +      + + PEV  K+ +EID V    R 
Sbjct: 235 NPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQ 294

Query: 354 VGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNN 411
               DR+ +PY EA I E  R+    P+ +     ++     + + KGT V+     +  
Sbjct: 295 PKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLR 354

Query: 412 SEQYWSEPEKFDPSRFLEK 430
              ++S P+ F+P  FL +
Sbjct: 355 DPSFFSNPQDFNPQHFLNE 373



 Score = 45.6 bits (103), Expect = 4e-04
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 5/67 (7%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV-GVENINDLKQKPACV---ALPKNTY 528
           F+PFSIGKR C G+ +     F  F  +MQ+F +   ++  D+   P  V    +P+N Y
Sbjct: 383 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN-Y 441

Query: 529 KMHLIPR 535
            M  +PR
Sbjct: 442 TMSFLPR 448


>M29873-1|AAA52143.1|  377|Homo sapiens CYP2B protein.
          Length = 377

 Score = 88.6 bits (210), Expect = 5e-17
 Identities = 90/358 (25%), Positives = 151/358 (42%), Gaps = 24/358 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE L  
Sbjct: 32  PGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           N    +GR   +    ++ G          W                 K+  +   +   
Sbjct: 91  NAEAFSGRGKIVIMDPVYQGYGMLFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQD-- 148

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K ++ 
Sbjct: 149 ----EAQCLIEELR---KSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNL 201

Query: 224 FDEIFW---EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F + F     I+      F  +L  F   H +   N  Q+I ++I   + + RE  LD  
Sbjct: 202 FCQSFLLISSISSQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TLDPS 259

Query: 281 APEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
           AP +D +D  L  + ++ +        +N II  L  F  G  +    +      + + P
Sbjct: 260 AP-RDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYP 318

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENAN 390
            V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R+A   P+ VPH+ T++ +
Sbjct: 319 HVAERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHIVTQHTS 376


>BC041174-1|AAH41174.1|  377|Homo sapiens CYP2B7P1 protein protein.
          Length = 377

 Score = 88.6 bits (210), Expect = 5e-17
 Identities = 90/358 (25%), Positives = 151/358 (42%), Gaps = 24/358 (6%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P++G+L L        ++F    +KYGD+F+V LG    V++  +  IRE L  
Sbjct: 32  PGPRPLPLLGNL-LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
           N    +GR   +    ++ G          W                 K+  +   +   
Sbjct: 91  NAEAFSGRGKIVIMDPVYQGYGMLFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQD-- 148

Query: 164 VGTFESVELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDH 223
               E+  LI+ L+       A +D   +      N+  + +   RF  +D EF K ++ 
Sbjct: 149 ----EAQCLIEELR---KSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNL 201

Query: 224 FDEIFW---EINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTE 280
           F + F     I+      F  +L  F   H +   N  Q+I ++I   + + RE  LD  
Sbjct: 202 FCQSFLLISSISSQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE-TLDPS 259

Query: 281 APEKDFLDGLLRVLHEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDP 334
           AP +D +D  L  + ++ +        +N II  L  F  G  +    +      + + P
Sbjct: 260 AP-RDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYP 318

Query: 335 EVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYAS-SPI-VPHVATENAN 390
            V  ++ +EI+ V    RP  L DR+ +PYTEA I E  R+A   P+ VPH+ T++ +
Sbjct: 319 HVAERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHIVTQHTS 376


>AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 144

 Score = 86.2 bits (204), Expect = 3e-16
 Identities = 45/121 (37%), Positives = 68/121 (56%), Gaps = 2/121 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 23  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 82

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSE 418
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ ++ W  
Sbjct: 83  HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 142

Query: 419 P 419
           P
Sbjct: 143 P 143


>M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.
          Length = 383

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 69/244 (28%), Positives = 122/244 (50%), Gaps = 20/244 (8%)

Query: 203 NYMCSV----RFDDEDLEFQKIVDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLS 255
           N +CS+    RFD +D +F  +++  +E    ++  +     +F P +  F   H + L 
Sbjct: 69  NVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK 128

Query: 256 NWSQDIRSFILSRIVEQREINLDTEAPEKDFLDG-LLRVLHEDPTMDRNTIIFMLED--- 311
           N +  ++S+IL ++ E +E ++D   P+ DF+D  L+++  E         I  LE+   
Sbjct: 129 NVAF-MKSYILEKVKEHQE-SMDMNNPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAV 185

Query: 312 --FLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATI 369
             F  G  +    +   L  + + PEV  K+++EI+ V    R   + DRSH+PYT+A +
Sbjct: 186 DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVV 245

Query: 370 LECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSR 426
            E  R        +PH  T +     Y I KGT + I+   VL++++++   PE FDP  
Sbjct: 246 HEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHH 304

Query: 427 FLEK 430
           FL++
Sbjct: 305 FLDE 308



 Score = 37.1 bits (82), Expect = 0.16
 Identities = 14/39 (35%), Positives = 23/39 (58%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F    +I+Q+F +
Sbjct: 313 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 351


>AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 100/421 (23%), Positives = 171/421 (40%), Gaps = 43/421 (10%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+F+++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFNLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHAR 160
           +   G   A RP    +  L  G R+  + L  +                    T  +  
Sbjct: 91  MVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWREQRRFSVS-------TLRNLG 143

Query: 161 IGTVGTFESVELIQTLKGLTSRSDASIDLKP--ILMKSAMNMFSNYMCSVRFDDEDLEFQ 218
           +G     + V              A    +P  +L K+  N+ ++  C  RF+ +D  F 
Sbjct: 144 LGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 203

Query: 219 KIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVE---QREI 275
           +++D   E   E   G+  + L  +      H+  L+      +   L+++ E   +  +
Sbjct: 204 RLLDLAQEGLKE-ESGFLREVLNAVPVL--PHIPALAGKVLRFQKAFLTQLDELLTEHRM 260

Query: 276 NLDTEAPEKDFLDGLLRVLH------EDPTMDRNTIIFMLEDFLGGHSSV------GNLV 323
             D   P +D  +  L          E    D N  I +   FL G  +       G L+
Sbjct: 261 TWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVGNLFLAGMVTTLTTLAWGLLL 320

Query: 324 MLCLTAVAR--------DPEVGR-----KIRQEIDAVTRGKRPVGLTDRSHLPYTEATIL 370
           M+    V R         P VG      +++QEID V    R   + D+ H+PYT A I 
Sbjct: 321 MILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQVRRPEMGDQVHMPYTTAVIH 380

Query: 371 ECLRYASS-PI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFL 428
           E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W +P +F P  FL
Sbjct: 381 EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 440

Query: 429 E 429
           +
Sbjct: 441 D 441



 Score = 36.7 bits (81), Expect = 0.21
 Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 2/65 (3%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQ--SFEVGVENINDLKQKPACVALPKNTYKM 530
           F+PFS G+R C+G+ +     F  F +++Q  SF V          +     +  + Y++
Sbjct: 452 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPYEL 511

Query: 531 HLIPR 535
             +PR
Sbjct: 512 CAVPR 516


>L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.
          Length = 468

 Score = 84.6 bits (200), Expect = 8e-16
 Identities = 63/243 (25%), Positives = 117/243 (48%), Gaps = 18/243 (7%)

Query: 203 NYMCSV----RFDDEDLEFQKIVDHFDEIFWEINQGYA--VDFLPWLAPFYKKHMEKLSN 256
           N +CS+    RFD +D +F  +++  +E    ++  +    +  P +  ++     KL  
Sbjct: 154 NVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLK 213

Query: 257 WSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDPTMDRN-----TIIFMLED 311
               + S IL ++ E +E ++D   P +DF+D  L  + ++    ++      ++    D
Sbjct: 214 NLAFMESDILEKVKEHQE-SMDINNP-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAAD 271

Query: 312 FLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATIL 370
            LG G  +    +   L  + + PEV  K+++EI+ V    R   + DR H+PYT+A + 
Sbjct: 272 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 331

Query: 371 ECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEPEKFDPSRF 427
           E  RY       +PH  T +     Y I KGT +  +   VL++++++   PE FDP  F
Sbjct: 332 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHF 390

Query: 428 LEK 430
           L++
Sbjct: 391 LDE 393



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 398 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 436



 Score = 31.9 bits (69), Expect = 5.9
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 70  ELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRPDF 114
           +LSK YG +F++  G    VV++   +++E L   G   +GR  F
Sbjct: 34  QLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF 78


>M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 101/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + PTM+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PTMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 101/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E VE 
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPVEE 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 -QLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens
           cDNA FLJ20359 fis, clone HEP16626. ).
          Length = 408

 Score = 83.4 bits (197), Expect = 2e-15
 Identities = 88/371 (23%), Positives = 157/371 (42%), Gaps = 27/371 (7%)

Query: 70  ELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRPDFLRFHKLFAGDRNNSL 129
           ELS++YG +F+V LG    VV+     ++E L   G  +A RP    F  +  G      
Sbjct: 2   ELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFS 61

Query: 130 ALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVELIQTLKGLTSRSDASIDL 189
           +   W                       H+ +G      + +++Q LK L+ + D     
Sbjct: 62  SGARWRAARQFTVRAL------------HS-LGVGREPVADKILQELKCLSGQLDGYRGR 108

Query: 190 K---PILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQ-GYAV-DFLPWLA 244
                +L  +  N+    +   RFD  D  F  ++   DE+   +   G  + +  PWL 
Sbjct: 109 PFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVHPWLG 168

Query: 245 PFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLH-EDPT---M 300
              + H   L    +++R+ IL  ++E R  ++    P   ++D L++    +DP     
Sbjct: 169 ALLQLHRPVLRK-IEEVRA-ILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFA 226

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           + N +   L+  + G  +    +      + R P+V  ++++E+D V    R   L D+ 
Sbjct: 227 EANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQ 286

Query: 361 HLPYTEATILECLRYAS-SPIVPHVATENANISGYGIEKGT-VVFINNYVLNNSEQYWSE 418
            LPYT A + E  R+ +  P VP     +  + G+ + KGT V+ +   VL +  Q W  
Sbjct: 287 ALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQ-WQT 345

Query: 419 PEKFDPSRFLE 429
           P +F+P  FL+
Sbjct: 346 PGQFNPGHFLD 356


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHCTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSKNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSKNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSKNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSKNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTENTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFRERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGTHLDETVWERPHEFWPDRFLE 411


>AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P450,
           subfamily XXIA (steroid 21-hydroxylase, congenital a
           protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 495

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.
          Length = 495

 Score = 81.8 bits (193), Expect = 6e-15
 Identities = 98/397 (24%), Positives = 183/397 (46%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSKNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNTIIFM--------LEDFLGGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +   +        ++  +GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 81.8 bits (193), Expect = 6e-15
 Identities = 100/397 (25%), Positives = 182/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLFHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 81.8 bits (193), Expect = 6e-15
 Identities = 99/396 (25%), Positives = 178/396 (44%), Gaps = 38/396 (9%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEIN 232
            Q  +    R  A       + +    +  + +C + F D+ ++   ++  + +   E+ 
Sbjct: 140 EQLTQEFCERMRAQPGTPVAIEEEFSPLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEVL 198

Query: 233 QGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDF 286
           + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D 
Sbjct: 199 KTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDM 256

Query: 287 LDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGR 338
           +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ +
Sbjct: 257 MDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQ 315

Query: 339 KIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISG 393
           ++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++ISG
Sbjct: 316 RLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISG 375

Query: 394 YGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           Y I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 YDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.
          Length = 446

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 14/249 (5%)

Query: 192 ILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHM 251
           +L K+  N+ ++  C  RF+ +D  F +++D   E   E   G+  + L  +      H+
Sbjct: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL--HI 182

Query: 252 EKLSNWSQDIRSFILSRIVE---QREINLDTEAPEKDFLDGLLRVLH------EDPTMDR 302
             L+      +   L+++ E   +  +  D   P +D  +  L  +       E    D 
Sbjct: 183 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 242

Query: 303 NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           N  I + + F  G  +    +   L  +   P+V R+++QEID V    R   + D++H+
Sbjct: 243 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 302

Query: 363 PYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPE 420
           PYT A I E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W +P 
Sbjct: 303 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 362

Query: 421 KFDPSRFLE 429
           +F P  FL+
Sbjct: 363 RFHPEHFLD 371



 Score = 52.0 bits (119), Expect = 5e-06
 Identities = 26/72 (36%), Positives = 43/72 (59%), Gaps = 1/72 (1%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRP 112
           L  +G   A RP
Sbjct: 91  LVTHGEDTADRP 102



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 382 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 417


>BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 446

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 14/249 (5%)

Query: 192 ILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHM 251
           +L K+  N+ ++  C  RF+ +D  F +++D   E   E   G+  + L  +      H+
Sbjct: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL--HI 182

Query: 252 EKLSNWSQDIRSFILSRIVE---QREINLDTEAPEKDFLDGLLRVLH------EDPTMDR 302
             L+      +   L+++ E   +  +  D   P +D  +  L  +       E    D 
Sbjct: 183 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 242

Query: 303 NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           N  I + + F  G  +    +   L  +   P+V R+++QEID V    R   + D++H+
Sbjct: 243 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 302

Query: 363 PYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPE 420
           PYT A I E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W +P 
Sbjct: 303 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 362

Query: 421 KFDPSRFLE 429
           +F P  FL+
Sbjct: 363 RFHPEHFLD 371



 Score = 52.0 bits (119), Expect = 5e-06
 Identities = 26/72 (36%), Positives = 43/72 (59%), Gaps = 1/72 (1%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRP 112
           L  +G   A RP
Sbjct: 91  LVTHGEDTADRP 102



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 382 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 417


>BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.
          Length = 446

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 14/249 (5%)

Query: 192 ILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHM 251
           +L K+  N+ ++  C  RF+ +D  F +++D   E   E   G+  + L  +      H+
Sbjct: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL--HI 182

Query: 252 EKLSNWSQDIRSFILSRIVE---QREINLDTEAPEKDFLDGLLRVLH------EDPTMDR 302
             L+      +   L+++ E   +  +  D   P +D  +  L  +       E    D 
Sbjct: 183 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 242

Query: 303 NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           N  I + + F  G  +    +   L  +   P+V R+++QEID V    R   + D++H+
Sbjct: 243 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 302

Query: 363 PYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPE 420
           PYT A I E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W +P 
Sbjct: 303 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 362

Query: 421 KFDPSRFLE 429
           +F P  FL+
Sbjct: 363 RFHPEHFLD 371



 Score = 52.0 bits (119), Expect = 5e-06
 Identities = 26/72 (36%), Positives = 43/72 (59%), Gaps = 1/72 (1%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R  PGP+  P +G+L  +    +P+  F +L +++GD+FS++L     VV+N L+ +RE 
Sbjct: 32  RYPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA 90

Query: 101 LNQNGNVVAGRP 112
           L  +G   A RP
Sbjct: 91  LVTHGEDTADRP 102



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 382 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 417


>M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.
          Length = 373

 Score = 80.6 bits (190), Expect = 1e-14
 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 14/249 (5%)

Query: 192 ILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHM 251
           +L K+  N+ ++  C  RF+ +D  F +++D   E   E   G+  + L  +      H+
Sbjct: 53  LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLL--HI 109

Query: 252 EKLSNWSQDIRSFILSRIVE---QREINLDTEAPEKDFLDGLLRVLH------EDPTMDR 302
             L+      +   L+++ E   +  +  D   P +D  +  L  +       E    D 
Sbjct: 110 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 169

Query: 303 NTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           N  I + + F  G  +    +   L  +   P+V R+++QEID V    R   + D++H+
Sbjct: 170 NLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 229

Query: 363 PYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPE 420
           PYT A I E  R+    P+ V H+ + +  + G+ I KGT +  N   +   E  W +P 
Sbjct: 230 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 289

Query: 421 KFDPSRFLE 429
           +F P  FL+
Sbjct: 290 RFHPEHFLD 298



 Score = 36.3 bits (80), Expect = 0.27
 Identities = 13/36 (36%), Positives = 21/36 (58%)

Query: 473 FIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEVGV 508
           F+PFS G+R C+G+ +     F  F +++Q F   V
Sbjct: 309 FLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 344


>X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase
           protein.
          Length = 495

 Score = 80.2 bits (189), Expect = 2e-14
 Identities = 99/397 (24%), Positives = 181/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 36  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 93

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 94  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 140

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 141 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 198

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + + R  I+   + Q + +L      +D
Sbjct: 199 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRD 256

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 257 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 315

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   D + LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 316 QRLQEELDHELGPGASSSRVPYKDHARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 375

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 376 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 412


>DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1
           protein.
          Length = 195

 Score = 80.2 bits (189), Expect = 2e-14
 Identities = 38/99 (38%), Positives = 60/99 (60%), Gaps = 2/99 (2%)

Query: 334 PEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANI 391
           P+V  +++ E+D V    R   + D+ +LPY  A + E +R++S  P+ + H  T N ++
Sbjct: 2   PDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTISHATTANTSV 61

Query: 392 SGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
            GY I K TVVF+N + +N+    W  PE FDP+RFL+K
Sbjct: 62  LGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDK 100


>AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 157

 Score = 79.8 bits (188), Expect = 2e-14
 Identities = 43/115 (37%), Positives = 65/115 (56%), Gaps = 2/115 (1%)

Query: 301 DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS 360
           D   I  +L+ F  G  +V   +   L  +  +P V RKI++E+D V    R   L+DRS
Sbjct: 43  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 102

Query: 361 HLPYTEATILECLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSE 413
           HLPY EA ILE  R++S  P  +PH  T + ++ G+ I KG  VF+N + +N+ +
Sbjct: 103 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ 157


>AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 79.4 bits (187), Expect = 3e-14
 Identities = 99/397 (24%), Positives = 181/397 (45%), Gaps = 40/397 (10%)

Query: 53  GSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRP 112
           G LHLL   + P      L++K+G I+ + LG  D VV+N+   I E + +     AGRP
Sbjct: 35  GFLHLLQP-DLPIYLLG-LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP 92

Query: 113 DFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGTVGTFESVEL 172
           + L + KL + +  + L+L D+S                K+ T S   +G   + E V +
Sbjct: 93  EPLTY-KLVSRNYPD-LSLGDYSLLWKAH----------KKLTRSALLLGIRDSMEPV-V 139

Query: 173 IQTLKGLTSRSDASIDLKPILMKSAMNMFS-NYMCSVRFDDEDLEFQKIVDHFDEIFWEI 231
            Q  +    R  A     P+ ++   ++ + + +C + F D+ ++   ++  + +   E+
Sbjct: 140 EQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICYLTFGDK-IKDDNLMPAYYKCIQEV 197

Query: 232 NQGYA------VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKD 285
            + ++      VD +P+L  F    + +L   + +    I+   + Q + +L      +D
Sbjct: 198 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQ-AIEKGDHIVEMQLRQHKESL-VAGQWRD 255

Query: 286 FLDGLLRVLHEDPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVG 337
            +D +L+ + + P+M+  +       +     D L GG  +  N +   +  +   PE+ 
Sbjct: 256 MMDYMLQGVAQ-PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 314

Query: 338 RKIRQEID---AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANIS 392
           +++++E+D           V   DR+ LP   ATI E LR     P+ +PH  T  ++IS
Sbjct: 315 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 374

Query: 393 GYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
           GY I +GTV+  N    +  E  W  P +F P RFLE
Sbjct: 375 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 411


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 54/204 (26%), Positives = 98/204 (48%), Gaps = 10/204 (4%)

Query: 239 FLPWLAPFYKKHMEKLSN--WSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           FL  + PF    +E L+   + +++ +F+   +   +E  L DT+    DFL  ++   +
Sbjct: 220 FLSIIFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 279

Query: 296 EDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV  
Sbjct: 280 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 339

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y 
Sbjct: 340 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYA 399

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L+   +YW+EPEKF P RF +K +
Sbjct: 400 LHRDPKYWTEPEKFLPERFSKKNK 423


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 72  SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 129

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 130 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 189

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 190 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 249

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 250 ALHRDPKYWTEPEKFLPERFSKKNK 274


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 149 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 206

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 207 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 266

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 267 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 326

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 327 ALHRDPKYWTEPEKFLPERFSKKNK 351


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 variant protein.
          Length = 336

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 64/246 (26%), Positives = 119/246 (48%), Gaps = 20/246 (8%)

Query: 199 NMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAV---DFLPWLAPFYKKHMEKLS 255
           N+ ++ +    FD  D +F +++  F+E F  ++  +     +F  +L      H + + 
Sbjct: 74  NVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIK 133

Query: 256 NWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDP-------TMDRNTIIFM 308
           N ++ ++ ++  R+ E  + +LD   P +D  D LL  + ++        TMD  T+  +
Sbjct: 134 NVAE-VKEYVSERVKEHHQ-SLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVT-V 189

Query: 309 LEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEAT 368
            + F  G  +    +   L  + + PE+  K+ +EID V    R   + DR  +PY +A 
Sbjct: 190 ADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAV 249

Query: 369 ILECLRYAS--SPIVPHVATENANISGYGIEKGTVVF--INNYVLNNSEQYWSEPEKFDP 424
           + E  R+ +     +PH AT +    GY I KGTVV   +++ + +N E  + +PEKF P
Sbjct: 250 VHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE--FPDPEKFKP 307

Query: 425 SRFLEK 430
             FL +
Sbjct: 308 EHFLNE 313


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score = 77.8 bits (183), Expect = 9e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score = 77.8 bits (183), Expect = 9e-14
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G+ +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 51/205 (24%), Positives = 97/205 (47%), Gaps = 10/205 (4%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279

Query: 295 HEDPT------MDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT 348
           +   T       D   +   +     G  +  +++   +  +A  P+V +K+++EIDAV 
Sbjct: 280 NSKETESHKALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339

Query: 349 RGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNY 407
             K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +Y
Sbjct: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399

Query: 408 VLNNSEQYWSEPEKFDPSRFLEKTR 432
            L+   +YW+EPEKF P RF +K +
Sbjct: 400 ALHRDPKYWTEPEKFLPERFSKKNK 424


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score = 76.2 bits (179), Expect = 3e-13
 Identities = 51/206 (24%), Positives = 98/206 (47%), Gaps = 11/206 (5%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSH 279

Query: 295 HEDPTMDRNTIIFMLE-------DFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAV 347
                 + +  +  LE           G+ +  +++   +  +A  P+V +K+++EIDAV
Sbjct: 280 KNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 339

Query: 348 TRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINN 406
              K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +
Sbjct: 340 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPS 399

Query: 407 YVLNNSEQYWSEPEKFDPSRFLEKTR 432
           Y L+   +YW+EPEKF P RF +K +
Sbjct: 400 YALHRDPKYWTEPEKFLPERFSKKNK 425


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score = 76.2 bits (179), Expect = 3e-13
 Identities = 51/206 (24%), Positives = 98/206 (47%), Gaps = 11/206 (5%)

Query: 236 AVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVL 294
           ++   P+L P  +  +  +  + +++ +F+   +   +E  L DT+    DFL  ++   
Sbjct: 222 SITVFPFLIPILE--VLNICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSH 279

Query: 295 HEDPTMDRNTIIFMLE-------DFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAV 347
                 + +  +  LE           G+ +  +++   +  +A  P+V +K+++EIDAV
Sbjct: 280 KNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 339

Query: 348 TRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINN 406
              K P        + Y +  + E LR +  +  +  V  ++  I+G  I KG VV I +
Sbjct: 340 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPS 399

Query: 407 YVLNNSEQYWSEPEKFDPSRFLEKTR 432
           Y L+   +YW+EPEKF P RF +K +
Sbjct: 400 YALHRDPKYWTEPEKFLPERFSKKNK 425


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score = 75.8 bits (178), Expect = 4e-13
 Identities = 39/119 (32%), Positives = 66/119 (55%), Gaps = 1/119 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   +  +A  P+V +K+++EID V   K P        L Y +  + E LR
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR 365

Query: 375 -YASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTR 432
            +  +  +  V  ++  I+G  I KG VV I +YVL++  +YW+EPEKF P RF +K +
Sbjct: 366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score = 75.8 bits (178), Expect = 4e-13
 Identities = 39/119 (32%), Positives = 66/119 (55%), Gaps = 1/119 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   +  +A  P+V +K+++EID V   K P        L Y +  + E LR
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR 365

Query: 375 -YASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTR 432
            +  +  +  V  ++  I+G  I KG VV I +YVL++  +YW+EPEKF P RF +K +
Sbjct: 366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score = 75.8 bits (178), Expect = 4e-13
 Identities = 39/119 (32%), Positives = 66/119 (55%), Gaps = 1/119 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   +  +A  P+V +K+++EID V   K P        L Y +  + E LR
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR 365

Query: 375 -YASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTR 432
            +  +  +  V  ++  I+G  I KG VV I +YVL++  +YW+EPEKF P RF +K +
Sbjct: 366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score = 75.8 bits (178), Expect = 4e-13
 Identities = 39/119 (32%), Positives = 66/119 (55%), Gaps = 1/119 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   +  +A  P+V +K+++EID V   K P        L Y +  + E LR
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR 365

Query: 375 -YASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEKTR 432
            +  +  +  V  ++  I+G  I KG VV I +YVL++  +YW+EPEKF P RF +K +
Sbjct: 366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK 424


>BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family 4,
           subfamily V, polypeptide 2 protein.
          Length = 525

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 292 RVLHEDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT-RG 350
           R+ HED   + +T  FM E    GH +    +   L  +  +PEV +K+  E+D V  + 
Sbjct: 313 RLSHEDIREEVDT--FMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366

Query: 351 KRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYVL 409
            RP  + D   L Y E  I E LR + S P+     +E+  ++GY + KGT   I  Y L
Sbjct: 367 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 426

Query: 410 NNSEQYWSEPEKFDPSRF 427
           +   +Y+  PE+F P RF
Sbjct: 427 HRDPRYFPNPEEFQPERF 444


>AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2
           protein.
          Length = 525

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 292 RVLHEDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT-RG 350
           R+ HED   + +T  FM E    GH +    +   L  +  +PEV +K+  E+D V  + 
Sbjct: 313 RLSHEDIREEVDT--FMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366

Query: 351 KRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYVL 409
            RP  + D   L Y E  I E LR + S P+     +E+  ++GY + KGT   I  Y L
Sbjct: 367 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 426

Query: 410 NNSEQYWSEPEKFDPSRF 427
           +   +Y+  PE+F P RF
Sbjct: 427 HRDPRYFPNPEEFQPERF 444


>AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43.3
           protein.
          Length = 503

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLA 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens
           cDNA FLJ44509 fis, clone UTERU3001585, weakly  similar
           to Cytochrome P450 4c3 (EC 1.14.-.-). ).
          Length = 503

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 292 RVLHEDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT-RG 350
           R+ HED   + +T  FM E    GH +    +   L  +  +PEV +K+  E+D V  + 
Sbjct: 291 RLSHEDIREEVDT--FMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 344

Query: 351 KRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYVL 409
            RP  + D   L Y E  I E LR + S P+     +E+  ++GY + KGT   I  Y L
Sbjct: 345 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 404

Query: 410 NNSEQYWSEPEKFDPSRF 427
           +   +Y+  PE+F P RF
Sbjct: 405 HRDPRYFPNPEEFQPERF 422


>AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16007 fis, clone KIDNE2006580, weakly  similar
           to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
          Length = 525

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 292 RVLHEDPTMDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVT-RG 350
           R+ HED   + +T  FM E    GH +    +   L  +  +PEV +K+  E+D V  + 
Sbjct: 313 RLSHEDIREEVDT--FMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366

Query: 351 KRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYVL 409
            RP  + D   L Y E  I E LR + S P+     +E+  ++GY + KGT   I  Y L
Sbjct: 367 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 426

Query: 410 NNSEQYWSEPEKFDPSRF 427
           +   +Y+  PE+F P RF
Sbjct: 427 HRDPRYFPNPEEFQPERF 444


>AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450
           epoxygenase protein.
          Length = 339

 Score = 74.1 bits (174), Expect = 1e-12
 Identities = 79/340 (23%), Positives = 145/340 (42%), Gaps = 28/340 (8%)

Query: 44  PGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQ 103
           PGP   P +G+  L+   +S  +    + KKYG++FS++LG    V++  L LI+E L  
Sbjct: 14  PGPWRLPFLGNFFLVDFEQSHLEVQLFV-KKYGNLFSLELGDISAVLITGLPLIKEALIH 72

Query: 104 NGNVVAGRPDFLRFHKLFAGDRNNSLALCDWSXXXXXXXXXXXXHCGPKQHTDSHARIGT 163
                  RP       +F   + N L +                          +  +G 
Sbjct: 73  MDQNFGNRPVTPMREHIF---KKNGLIMSSGQAWKEQRRFTLTAL--------RNFGLGK 121

Query: 164 VGTFESV--ELIQTLKGLTSRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIV 221
            G  E +  E     + +   +    D    +  +  N+  +     RF+ +D  FQ+++
Sbjct: 122 KGLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLL 181

Query: 222 DHFDEI-FWEINQGYAV-DFLPWLAPFYK-KHMEKLSNWSQDIRSFILSRIVEQREINLD 278
              DE+ + E ++   + +  PW+  F    H    SNW + ++ F+ S ++++   + +
Sbjct: 182 KLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKK-LKLFV-SHMIDKHRKDWN 239

Query: 279 TEAPEKDFLDGLLRVLHE---DPTM---DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVAR 332
             A  +DF+D  L+ + +   +PT    + N I   L+ F  G  +    +   L  +A 
Sbjct: 240 -PAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMAL 298

Query: 333 DPEVGRKIRQEIDAVT-RGKRPVGLTDRSHLPYTEATILE 371
            PE+  K++ EID V  +G++P     R  +PYT A I E
Sbjct: 299 YPEIQEKVQVEIDRVIGQGQQP-STAARESMPYTNAVIHE 337


>BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein
           protein.
          Length = 310

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 5/132 (3%)

Query: 304 TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           ++I  + D  G G  +    +   L  + + PEV  K+++EI+ V    R   + DRSH+
Sbjct: 106 SLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHM 165

Query: 363 PYTEATILECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEP 419
           PYT+A + E  RY       +PH  T +     Y I KGT +  +   VL+N +++   P
Sbjct: 166 PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEF-PNP 224

Query: 420 EKFDPSRFLEKT 431
           E FDP  FL+K+
Sbjct: 225 EMFDPGHFLDKS 236



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 240 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 278


>BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.
          Length = 431

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 5/132 (3%)

Query: 304 TIIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHL 362
           ++I  + D  G G  +    +   L  + + PEV  K+++EI+ V    R   + DRSH+
Sbjct: 227 SLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHM 286

Query: 363 PYTEATILECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEP 419
           PYT+A + E  RY       +PH  T +     Y I KGT +  +   VL+N +++   P
Sbjct: 287 PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEF-PNP 345

Query: 420 EKFDPSRFLEKT 431
           E FDP  FL+K+
Sbjct: 346 EMFDPGHFLDKS 357



 Score = 42.3 bits (95), Expect = 0.004
 Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 1/74 (1%)

Query: 41  RTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREV 100
           R   GP   PIIG++  L   +   ++ T  SK YG +F+V  G    VV++    ++E 
Sbjct: 28  RLPSGPTPLPIIGNILQLDVKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEA 86

Query: 101 LNQNGNVVAGRPDF 114
           L  +G   +GR  F
Sbjct: 87  LIDHGEEFSGRGSF 100



 Score = 35.5 bits (78), Expect = 0.48
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 399


>AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43.1
           protein.
          Length = 503

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43
           protein.
          Length = 503

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.
          Length = 503

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 10/204 (4%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSRFLEKTR 432
           L++  +YW+EPEKF P RF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPERFSKKNK 424


>BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.
          Length = 393

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 50/200 (25%), Positives = 90/200 (45%), Gaps = 10/200 (5%)

Query: 241 PWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLHEDPT 299
           P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +   T
Sbjct: 117 PFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKET 174

Query: 300 M------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRP 353
                  D   +   +      + +    +   +  +A  P+V +K+++EIDAV   K P
Sbjct: 175 KSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP 234

Query: 354 VGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNS 412
           V       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y L++ 
Sbjct: 235 VTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHD 294

Query: 413 EQYWSEPEKFDPSRFLEKTR 432
            +YW+EPEKF P RF +K +
Sbjct: 295 PKYWTEPEKFCPERFSKKNK 314


>X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120
           AA) protein.
          Length = 210

 Score = 72.1 bits (169), Expect = 4e-12
 Identities = 40/121 (33%), Positives = 61/121 (50%), Gaps = 2/121 (1%)

Query: 312 FLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILE 371
           F+ G  +    +   L  + + PEV  K+++EID V    R   + DRSH+PYT+A + E
Sbjct: 15  FVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHE 74

Query: 372 CLRYAS-SPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLE 429
             RY+   P  VPH  T +     Y I KGT +      + + ++ +  P  FDP  FL+
Sbjct: 75  IQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDREFPNPNIFDPGHFLD 134

Query: 430 K 430
           K
Sbjct: 135 K 135



 Score = 39.5 bits (88), Expect = 0.029
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV----GVENINDLKQKPACVAL 523
           K   +F+PFS GKR C G+ +     F     I+Q+F +     ++N+N        V+L
Sbjct: 140 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 199

Query: 524 PKNTYKMHLIP 534
           P  +Y++  IP
Sbjct: 200 PP-SYQICFIP 209


>AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 504

 Score = 70.9 bits (166), Expect = 1e-11
 Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 11/205 (5%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDP-SRFLEKTR 432
           L++  +YW+EPEKF P SRF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPESRFSKKNK 425


>AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.
          Length = 504

 Score = 70.9 bits (166), Expect = 1e-11
 Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 11/205 (5%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDP-SRFLEKTR 432
           L++  +YW+EPEKF P SRF +K +
Sbjct: 401 LHHDPKYWTEPEKFCPESRFSKKNK 425


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 1/117 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   L  +A  P+V +K+++EIDAV   K P        + Y +  + E LR
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 375 YASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                I +     ++  I+G  I KG++V I  Y L++  +YW+EPE+F P RF +K
Sbjct: 366 LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 1/117 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   L  +A  P+V +K+++EIDAV   K P        + Y +  + E LR
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 375 YASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                I +     ++  I+G  I KG++V I  Y L++  +YW+EPE+F P RF +K
Sbjct: 366 LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 1/117 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   L  +A  P+V +K+++EIDAV   K P        + Y +  + E LR
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 375 YASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                I +     ++  I+G  I KG++V I  Y L++  +YW+EPE+F P RF +K
Sbjct: 366 LFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 1/117 (0%)

Query: 315 GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLPYTEATILECLR 374
           G+ +  +++   L  +A  P+V +K+++EIDAV   K P        + Y +  + E LR
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 375 YASSPI-VPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPEKFDPSRFLEK 430
                I +     ++  I+G  I KG++V I  Y L++  +YW+EPE+F P RF +K
Sbjct: 366 LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422


>L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxylase
           protein.
          Length = 217

 Score = 70.1 bits (164), Expect = 2e-11
 Identities = 40/130 (30%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 305 IIFMLEDFLG-GHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRSHLP 363
           ++    D LG G  +    +   L  + + PEV  K+++EI+ V    R   + DR H+P
Sbjct: 14  LVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMP 73

Query: 364 YTEATILECLRYAS--SPIVPHVATENANISGYGIEKGTVVFIN-NYVLNNSEQYWSEPE 420
           YT+A + E  RY       +PH  T +     Y I KGT +  +   VL++++++   PE
Sbjct: 74  YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPE 132

Query: 421 KFDPSRFLEK 430
            FDP  FL++
Sbjct: 133 MFDPRHFLDE 142



 Score = 34.7 bits (76), Expect = 0.83
 Identities = 14/39 (35%), Positives = 22/39 (56%)

Query: 468 KNIPHFIPFSIGKRTCIGQTMVTSMSFTMFANIMQSFEV 506
           K   +F+PFS GKR C+G+ +     F     I+Q+F +
Sbjct: 147 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 185


>AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 420

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 10/198 (5%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINL-DTEAPEKDFLDGLLRVLH 295
           +   P+L P ++     +  + +D+  F+ + I   +E  L D +    DF   ++   +
Sbjct: 223 ISLFPFLTPVFEAL--NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

Query: 296 EDPTM------DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTR 349
              T       D   +   +      + +    +   +  +A  P+V +K+++EIDAV  
Sbjct: 281 SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 340

Query: 350 GKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFINNYV 408
            K PV       + Y +  + E LR +     V  V  ++  I+G  I KG  V +  Y 
Sbjct: 341 NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYA 400

Query: 409 LNNSEQYWSEPEKFDPSR 426
           L++  +YW+EPEKF P R
Sbjct: 401 LHHDPKYWTEPEKFCPER 418


>BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 464

 Score = 68.5 bits (160), Expect = 6e-11
 Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 179 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDMMDYMLQGVAQ 236

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +   +  +   PE+ +++++E+D   
Sbjct: 237 -PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHEL 295

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 296 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 355

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 356 PNLQGAHLDETVWERPHEFWPDRFLE 381


>AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.5 bits (160), Expect = 6e-11
 Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 180 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDMMDYMLQGVAQ 237

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +   +  +   PE+ +++++E+D   
Sbjct: 238 -PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHEL 296

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 297 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 356

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 357 PNLQGAHLDETVWERPHEFWPDRFLE 382


>AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.5 bits (160), Expect = 6e-11
 Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 180 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDMMDYMLQGVAQ 237

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +   +  +   PE+ +++++E+D   
Sbjct: 238 -PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHEL 296

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 297 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 356

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 357 PNLQGAHLDETVWERPHEFWPDRFLE 382


>AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.5 bits (160), Expect = 6e-11
 Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 180 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDMMDYMLQGVAQ 237

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +   +  +   PE+ +++++E+D   
Sbjct: 238 -PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHEL 296

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 297 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 356

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 357 PNLQGAHLDETVWERPHEFWPDRFLE 382


>AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 403

 Score = 68.5 bits (160), Expect = 6e-11
 Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 118 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLRQHKESL-VAGQWRDMMDYMLQGVAQ 175

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +   +  +   PE+ +++++E+D   
Sbjct: 176 -PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHEL 234

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 235 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 294

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 295 PNLQGAHLDETVWERPHEFWPDRFLE 320


>X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase
           protein.
          Length = 530

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 8/212 (3%)

Query: 232 NQGYAVDFLP-WLAPFYKKHMEKLSNWSQDIRSF---ILSRIVEQREINLDTEAPEKDFL 287
           N  YA  FLP W  P        L  W+  I SF   ++   +E  E  L    P+   +
Sbjct: 249 NSLYAT-FLPKWTRPVLPFWKRYLDGWNA-IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV 306

Query: 288 DGLLRVLHEDPTMDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDA 346
            G L  L     +     +  L + L  G  +  N +   L  +++DPE+   + +E+  
Sbjct: 307 SGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVG 366

Query: 347 VTRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFIN 405
           V    +     D +H+P  +A + E LR Y   P    +  +   + G+   K T     
Sbjct: 367 VVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFC 426

Query: 406 NYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRR 437
           +YV++     +SEPE F P R+L  ++  T R
Sbjct: 427 HYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 458


>M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase
           protein.
          Length = 531

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 8/212 (3%)

Query: 232 NQGYAVDFLP-WLAPFYKKHMEKLSNWSQDIRSF---ILSRIVEQREINLDTEAPEKDFL 287
           N  YA  FLP W  P        L  W+  I SF   ++   +E  E  L    P+   +
Sbjct: 250 NSLYAT-FLPKWTRPVLPFWKRYLDGWNA-IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV 307

Query: 288 DGLLRVLHEDPTMDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDA 346
            G L  L     +     +  L + L  G  +  N +   L  +++DPE+   + +E+  
Sbjct: 308 SGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVG 367

Query: 347 VTRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFIN 405
           V    +     D +H+P  +A + E LR Y   P    +  +   + G+   K T     
Sbjct: 368 VVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFC 427

Query: 406 NYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRR 437
           +YV++     +SEPE F P R+L  ++  T R
Sbjct: 428 HYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459


>DQ372705-1|ABD16216.1|  150|Homo sapiens mutant cytochrome p450
           protein.
          Length = 150

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 3/85 (3%)

Query: 40  LRTAP-GPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIR 98
           LR+AP GP  WP+IG+   +G  ++   +F  L+++YGD+F ++LGS   VV+N    I 
Sbjct: 47  LRSAPPGPFAWPLIGNAAAVG--QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIH 104

Query: 99  EVLNQNGNVVAGRPDFLRFHKLFAG 123
           + L Q G+  A RP F  F  +  G
Sbjct: 105 QALVQQGSAFADRPAFASFRVVSGG 129


>BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 8/212 (3%)

Query: 232 NQGYAVDFLP-WLAPFYKKHMEKLSNWSQDIRSF---ILSRIVEQREINLDTEAPEKDFL 287
           N  YA  FLP W  P        L  W+  I SF   ++   +E  E  L    P+   +
Sbjct: 250 NSLYAT-FLPKWTRPVLPFWKRYLDGWNA-IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV 307

Query: 288 DGLLRVLHEDPTMDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDA 346
            G L  L     +     +  L + L  G  +  N +   L  +++DPE+   + +E+  
Sbjct: 308 SGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVG 367

Query: 347 VTRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFIN 405
           V    +     D +H+P  +A + E LR Y   P    +  +   + G+   K T     
Sbjct: 368 VVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFC 427

Query: 406 NYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRR 437
           +YV++     +SEPE F P R+L  ++  T R
Sbjct: 428 HYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459


>BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 8/212 (3%)

Query: 232 NQGYAVDFLP-WLAPFYKKHMEKLSNWSQDIRSF---ILSRIVEQREINLDTEAPEKDFL 287
           N  YA  FLP W  P        L  W+  I SF   ++   +E  E  L    P+   +
Sbjct: 250 NSLYAT-FLPKWTRPVLPFWKRYLDGWNA-IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV 307

Query: 288 DGLLRVLHEDPTMDRNTIIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDA 346
            G L  L     +     +  L + L  G  +  N +   L  +++DPE+   + +E+  
Sbjct: 308 SGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVG 367

Query: 347 VTRGKRPVGLTDRSHLPYTEATILECLR-YASSPIVPHVATENANISGYGIEKGTVVFIN 405
           V    +     D +H+P  +A + E LR Y   P    +  +   + G+   K T     
Sbjct: 368 VVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFC 427

Query: 406 NYVLNNSEQYWSEPEKFDPSRFLEKTRVRTRR 437
           +YV++     +SEPE F P R+L  ++  T R
Sbjct: 428 HYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459


>AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens
           cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
           CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
          Length = 465

 Score = 66.9 bits (156), Expect = 2e-10
 Identities = 57/206 (27%), Positives = 96/206 (46%), Gaps = 16/206 (7%)

Query: 237 VDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHE 296
           VD +P+L  F    + +L   + + R  I+   + Q + +L      +D +D +L+ + +
Sbjct: 180 VDVIPFLRFFPNPGLRRLKQ-AIEKRDHIVEMQLGQHKESL-VAGQWRDMMDYMLQGVAQ 237

Query: 297 DPTMDRNT-------IIFMLEDFL-GGHSSVGNLVMLCLTAVARDPEVGRKIRQEID--- 345
            P+M+  +       +     D L GG  +  N +      +   PE+ +++++E+D   
Sbjct: 238 -PSMEEGSGQLQEGHVHMAAVDLLIGGTETTANTLSWAAVFLLHHPEIQQRLQEELDHEL 296

Query: 346 AVTRGKRPVGLTDRSHLPYTEATILECLRYASS-PI-VPHVATENANISGYGIEKGTVVF 403
                   V   DR+ LP   ATI E LR     P+ +PH  T  ++ISGY I +GTV+ 
Sbjct: 297 GPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII 356

Query: 404 INNYVLNNSEQYWSEPEKFDPSRFLE 429
            N    +  E  W  P +F P RFLE
Sbjct: 357 PNLQGAHLDETVWERPHEFWPDRFLE 382


>AM236046-1|CAJ84703.1|  229|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 229

 Score = 66.5 bits (155), Expect = 2e-10
 Identities = 30/78 (38%), Positives = 48/78 (61%), Gaps = 2/78 (2%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRF 117
            L + G+   GRPD   F
Sbjct: 95  ALVRQGDDFKGRPDLYTF 112


>AM233520-1|CAJ80723.1|  189|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 189

 Score = 66.5 bits (155), Expect = 2e-10
 Identities = 30/78 (38%), Positives = 48/78 (61%), Gaps = 2/78 (2%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRF 117
            L + G+   GRPD   F
Sbjct: 95  ALVRQGDDFKGRPDLYTF 112


>AM233519-1|CAJ80722.1|  189|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 189

 Score = 66.5 bits (155), Expect = 2e-10
 Identities = 30/78 (38%), Positives = 48/78 (61%), Gaps = 2/78 (2%)

Query: 40  LRTAPGPVCWPIIGSLHLLGGHESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIRE 99
           L+  PGP  WP+IG +  LG  ++P  A + +S++YGD+  +++GS   VV++ L  IR+
Sbjct: 37  LKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94

Query: 100 VLNQNGNVVAGRPDFLRF 117
            L + G+   GRPD   F
Sbjct: 95  ALVRQGDDFKGRPDLYTF 112


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.321    0.137    0.412 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 76,877,537
Number of Sequences: 224733
Number of extensions: 3135800
Number of successful extensions: 6537
Number of sequences better than 10.0: 427
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 5100
Number of HSP's gapped (non-prelim): 1027
length of query: 536
length of database: 73,234,838
effective HSP length: 93
effective length of query: 443
effective length of database: 52,334,669
effective search space: 23184258367
effective search space used: 23184258367
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 68 (31.5 bits)