Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001730-TA|BGIBMGA001730-PA|IPR007122|Gelsolin,
IPR007123|Gelsolin region
(756 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X04412-1|CAA28000.1| 782|Homo sapiens plasma gelsolin protein. 385 e-106
BC026033-1|AAH26033.1| 782|Homo sapiens gelsolin (amyloidosis, ... 385 e-106
AL513122-6|CAM20459.1| 731|Homo sapiens gelsolin (amyloidosis, ... 385 e-106
AL513122-3|CAI14413.1| 782|Homo sapiens gelsolin (amyloidosis, ... 385 e-106
AK223398-1|BAD97118.1| 827|Homo sapiens villin 1 variant protein. 353 1e-96
BC021090-1|AAH21090.1| 715|Homo sapiens SCIN protein protein. 351 5e-96
X12901-1|CAA31386.1| 827|Homo sapiens protein ( Human mRNA for ... 351 7e-96
AK075123-1|BAC11416.1| 715|Homo sapiens protein ( Homo sapiens ... 350 9e-96
AF276507-1|AAK60494.1| 715|Homo sapiens scinderin protein. 349 2e-95
AF041449-1|AAC25051.1| 819|Homo sapiens advillin protein. 344 8e-94
BC111730-1|AAI11731.1| 812|Homo sapiens AVIL protein protein. 336 1e-91
AC005281-1|AAD15423.1| 527|Homo sapiens WUGSC:H_DJ0722F20.1 pro... 245 5e-64
AB067492-1|BAB67798.1| 626|Homo sapiens KIAA1905 protein protein. 245 5e-64
AK027778-1|BAB55361.1| 468|Homo sapiens protein ( Homo sapiens ... 200 1e-50
BC000243-1|AAH00243.1| 686|Homo sapiens VILL protein protein. 195 4e-49
D88154-1|BAA21668.1| 686|Homo sapiens villin-like protein protein. 195 6e-49
AL513122-7|CAI14416.1| 485|Homo sapiens gelsolin (amyloidosis, ... 190 2e-47
BC017303-1|AAH17303.1| 421|Homo sapiens VIL1 protein protein. 188 5e-47
BC004300-1|AAH04300.1| 672|Homo sapiens VILL protein protein. 184 1e-45
M94345-1|AAA59570.1| 348|Homo sapiens macrophage capping protei... 180 2e-44
BC014549-1|AAH14549.1| 348|Homo sapiens capping protein (actin ... 180 2e-44
BC000728-1|AAH00728.1| 348|Homo sapiens capping protein (actin ... 180 2e-44
AC062037-3|AAY24128.1| 348|Homo sapiens unknown protein. 180 2e-44
AL513122-5|CAI14415.1| 260|Homo sapiens gelsolin (amyloidosis, ... 177 1e-43
AK075198-1|BAC11465.1| 396|Homo sapiens protein ( Homo sapiens ... 176 3e-43
AL513122-4|CAI14414.1| 228|Homo sapiens gelsolin (amyloidosis, ... 175 6e-43
U80184-1|AAC02796.1| 1269|Homo sapiens FLII protein. 149 3e-35
U01184-1|AAC03568.1| 1268|Homo sapiens flightless-I homolog prot... 149 3e-35
BC025300-1|AAH25300.1| 1269|Homo sapiens flightless I homolog (D... 149 3e-35
BC017491-1|AAH17491.1| 285|Homo sapiens Similar to gelsolin (am... 145 4e-34
AB208864-1|BAD92101.1| 1101|Homo sapiens flightless I homolog va... 130 2e-29
U12026-1|AAA92670.1| 172|Homo sapiens Cap-G protein. 121 1e-26
AL513122-9|CAI14417.1| 207|Homo sapiens gelsolin (amyloidosis, ... 104 1e-21
AL513122-8|CAI14418.1| 188|Homo sapiens gelsolin (amyloidosis, ... 79 6e-14
AL160060-2|CAH71301.1| 1788|Homo sapiens supervillin protein. 73 5e-12
AL160060-1|CAH71300.1| 2214|Homo sapiens supervillin protein. 73 5e-12
AL158167-3|CAI15237.1| 2214|Homo sapiens supervillin protein. 73 5e-12
AL158167-2|CAI15236.1| 1788|Homo sapiens supervillin protein. 73 5e-12
AF109135-1|AAD14682.1| 2214|Homo sapiens archvillin protein. 73 5e-12
AF051851-1|AAC64696.1| 1788|Homo sapiens supervillin protein. 73 5e-12
AF051850-1|AAC64695.1| 1788|Homo sapiens supervillin protein. 73 5e-12
X07066-1|CAA30102.1| 69|Homo sapiens protein ( Human gene for ... 71 1e-11
BC075797-1|AAH75797.1| 85|Homo sapiens Unknown (protein for MG... 68 1e-10
AC073232-1|AAS07450.1| 100|Homo sapiens unknown protein. 59 5e-08
AB209574-1|BAD92811.1| 326|Homo sapiens villin-like variant pro... 52 6e-06
AK022448-1|BAB14038.1| 126|Homo sapiens protein ( Homo sapiens ... 38 0.13
AK024710-1|BAB14971.1| 288|Homo sapiens protein ( Homo sapiens ... 33 3.7
AK000867-1|BAA91401.1| 511|Homo sapiens protein ( Homo sapiens ... 33 3.7
D79984-1|BAA11479.2| 1730|Homo sapiens KIAA0162 protein. 33 4.9
AK131242-1|BAD18423.1| 268|Homo sapiens protein ( Homo sapiens ... 32 6.5
>X04412-1|CAA28000.1| 782|Homo sapiens plasma gelsolin protein.
Length = 782
Score = 385 bits (947), Expect = e-106
Identities = 239/744 (32%), Positives = 372/744 (50%), Gaps = 34/744 (4%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 54 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 113
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 114 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 168
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 169 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 228
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSD 239
+ +R K V+ +RD E +GRA + + +E + E + LG ++
Sbjct: 229 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE---AMLQVLGPKPALPAGTE 285
Query: 240 DTSESYTRSDISAVYLYKVLDGD---EQELVSMNKPYKQKHLASDAMYILDTGDTG-VYI 295
DT++ ++ LYKV +G LV+ P+ Q L S+ +ILD G G +++
Sbjct: 286 DTAKE-DAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFV 344
Query: 296 WLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGG 354
W G + + ++ + A ++ YP V+ + EG E+ FKQ+F NW D +T G
Sbjct: 345 WKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDG 404
Query: 355 SVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTD 414
+S + S + + AA + A+ M D G G + RI G + D
Sbjct: 405 LG---LSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVD 461
Query: 415 RFQQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLE 474
G Y + Y+I Y Y++ + ++Y W G++++ D+ A +L +QL+E+L
Sbjct: 462 PATYGQ--FYGGDSYIILYNYRHGGRQ-GQIIYNWQGAQSTQDEVAASAILTAQLDEELG 518
Query: 475 GNVTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET 534
G +V QGKE H +S+F G ++++ Q + S TRLF+V
Sbjct: 519 GTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS-----TRLFQVRANSA 573
Query: 535 GVDMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVT 594
G RAV+V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V
Sbjct: 574 GA-TRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQ 631
Query: 595 VVEQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
V E G EP+ FWEALGG + P GR E++
Sbjct: 632 VAE-GSEPDGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPG 686
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
E Q+DL+ D V +LDT ++++ W G D E K+ K+YIE D +R + + V
Sbjct: 687 ELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV 746
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWS 738
VKQG EP F F WDD WS
Sbjct: 747 -VKQGFEPPSFVGWFLGWDDDYWS 769
>BC026033-1|AAH26033.1| 782|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 782
Score = 385 bits (947), Expect = e-106
Identities = 239/744 (32%), Positives = 372/744 (50%), Gaps = 34/744 (4%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 54 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 113
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 114 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 168
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 169 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 228
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSD 239
+ +R K V+ +RD E +GRA + + +E + E + LG ++
Sbjct: 229 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE---AMLQVLGPKPALPAGTE 285
Query: 240 DTSESYTRSDISAVYLYKVLDGD---EQELVSMNKPYKQKHLASDAMYILDTGDTG-VYI 295
DT++ ++ LYKV +G LV+ P+ Q L S+ +ILD G G +++
Sbjct: 286 DTAKE-DAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFV 344
Query: 296 WLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGG 354
W G + + ++ + A ++ YP V+ + EG E+ FKQ+F NW D +T G
Sbjct: 345 WKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDG 404
Query: 355 SVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTD 414
+S + S + + AA + A+ M D G G + RI G + D
Sbjct: 405 LG---LSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVD 461
Query: 415 RFQQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLE 474
G Y + Y+I Y Y++ + ++Y W G++++ D+ A +L +QL+E+L
Sbjct: 462 PATYGQ--FYGGDSYIILYNYRHGGRQ-GQIIYNWQGAQSTQDEVAASAILTAQLDEELG 518
Query: 475 GNVTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET 534
G +V QGKE H +S+F G ++++ Q + S TRLF+V
Sbjct: 519 GTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS-----TRLFQVRANSA 573
Query: 535 GVDMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVT 594
G RAV+V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V
Sbjct: 574 GA-TRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQ 631
Query: 595 VVEQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
V E G EP+ FWEALGG + P GR E++
Sbjct: 632 VAE-GSEPDGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPG 686
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
E Q+DL+ D V +LDT ++++ W G D E K+ K+YIE D +R + + V
Sbjct: 687 ELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV 746
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWS 738
VKQG EP F F WDD WS
Sbjct: 747 -VKQGFEPPSFVGWFLGWDDDYWS 769
>AL513122-6|CAM20459.1| 731|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 731
Score = 385 bits (947), Expect = e-106
Identities = 239/744 (32%), Positives = 372/744 (50%), Gaps = 34/744 (4%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 3 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 62
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 63 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 117
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 118 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 177
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSD 239
+ +R K V+ +RD E +GRA + + +E + E + LG ++
Sbjct: 178 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE---AMLQVLGPKPALPAGTE 234
Query: 240 DTSESYTRSDISAVYLYKVLDGD---EQELVSMNKPYKQKHLASDAMYILDTGDTG-VYI 295
DT++ ++ LYKV +G LV+ P+ Q L S+ +ILD G G +++
Sbjct: 235 DTAKE-DAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFV 293
Query: 296 WLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGG 354
W G + + ++ + A ++ YP V+ + EG E+ FKQ+F NW D +T G
Sbjct: 294 WKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDG 353
Query: 355 SVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTD 414
+S + S + + AA + A+ M D G G + RI G + D
Sbjct: 354 LG---LSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVD 410
Query: 415 RFQQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLE 474
G Y + Y+I Y Y++ + ++Y W G++++ D+ A +L +QL+E+L
Sbjct: 411 PATYGQ--FYGGDSYIILYNYRHGGRQ-GQIIYNWQGAQSTQDEVAASAILTAQLDEELG 467
Query: 475 GNVTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET 534
G +V QGKE H +S+F G ++++ Q + S TRLF+V
Sbjct: 468 GTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS-----TRLFQVRANSA 522
Query: 535 GVDMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVT 594
G RAV+V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V
Sbjct: 523 GA-TRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQ 580
Query: 595 VVEQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
V E G EP+ FWEALGG + P GR E++
Sbjct: 581 VAE-GSEPDGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPG 635
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
E Q+DL+ D V +LDT ++++ W G D E K+ K+YIE D +R + + V
Sbjct: 636 ELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV 695
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWS 738
VKQG EP F F WDD WS
Sbjct: 696 -VKQGFEPPSFVGWFLGWDDDYWS 718
>AL513122-3|CAI14413.1| 782|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 782
Score = 385 bits (947), Expect = e-106
Identities = 239/744 (32%), Positives = 372/744 (50%), Gaps = 34/744 (4%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 54 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 113
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 114 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 168
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 169 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 228
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSD 239
+ +R K V+ +RD E +GRA + + +E + E + LG ++
Sbjct: 229 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE---AMLQVLGPKPALPAGTE 285
Query: 240 DTSESYTRSDISAVYLYKVLDGD---EQELVSMNKPYKQKHLASDAMYILDTGDTG-VYI 295
DT++ ++ LYKV +G LV+ P+ Q L S+ +ILD G G +++
Sbjct: 286 DTAKE-DAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFV 344
Query: 296 WLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGG 354
W G + + ++ + A ++ YP V+ + EG E+ FKQ+F NW D +T G
Sbjct: 345 WKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDG 404
Query: 355 SVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTD 414
+S + S + + AA + A+ M D G G + RI G + D
Sbjct: 405 LG---LSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVD 461
Query: 415 RFQQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLE 474
G Y + Y+I Y Y++ + ++Y W G++++ D+ A +L +QL+E+L
Sbjct: 462 PATYGQ--FYGGDSYIILYNYRHGGRQ-GQIIYNWQGAQSTQDEVAASAILTAQLDEELG 518
Query: 475 GNVTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET 534
G +V QGKE H +S+F G ++++ Q + S TRLF+V
Sbjct: 519 GTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS-----TRLFQVRANSA 573
Query: 535 GVDMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVT 594
G RAV+V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V
Sbjct: 574 GA-TRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQ 631
Query: 595 VVEQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
V E G EP+ FWEALGG + P GR E++
Sbjct: 632 VAE-GSEPDGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPG 686
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
E Q+DL+ D V +LDT ++++ W G D E K+ K+YIE D +R + + V
Sbjct: 687 ELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV 746
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWS 738
VKQG EP F F WDD WS
Sbjct: 747 -VKQGFEPPSFVGWFLGWDDDYWS 769
>AK223398-1|BAD97118.1| 827|Homo sapiens villin 1 variant protein.
Length = 827
Score = 353 bits (868), Expect = 1e-96
Identities = 237/744 (31%), Positives = 368/744 (49%), Gaps = 42/744 (5%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G++IW IE + VP +G F++GD YI+L + +SSL++D H+W+G ++ D++G+
Sbjct: 18 GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQGA 77
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
AAI+T +DD L GRAV HREVQG+ES F YFK L IR +GG SG V+TN
Sbjct: 78 AAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQ---GLVIR--KGGVASGMKHVETN 132
Query: 134 AGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKI-- 191
+ +RLL + G N+ EV S + F+L+ ++ G ++T+ ++
Sbjct: 133 SYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGK--LIIQWNGPESTRMERLRG 190
Query: 192 ISVANKLRDEEHNGRATIEIID---EFSSDEDVNLFFETLGS-GSMDELVSDDTSESYTR 247
+++A ++RD+E GR + ++D E +S + + + LG + V D E +
Sbjct: 191 MTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALK 250
Query: 248 SDISAVYLYKVLDGDEQELVS--MNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADV 305
+A+ LY V D + +V +P Q L+ + YILD G +Y+W G +
Sbjct: 251 ---AALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQE 307
Query: 306 KRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVRTGGSVRGIISEIDS 365
K+ A +++ K YP V ++GAES+ F+Q F W T S G + S
Sbjct: 308 KKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKW-TASNRTSGLGKTHTVGS 366
Query: 366 GYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGTSVLYQ 425
+ E+ A + + A+ M D G G + V RI + D G Y
Sbjct: 367 -VAKVEQEKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH--FYG 423
Query: 426 SEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQG 485
+ Y++ Y Y E+ +++Y+W GS+AS D+ A L++ G ++VP G
Sbjct: 424 GDCYLLLYTYL-IGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMG 482
Query: 486 KESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEE--DQTRLFRVEGTETGVDMRAVQV 543
KE H +SIFKG +VV YQ S+ + E TRLF+V+GT + +A +V
Sbjct: 483 KEPPHLMSIFKGRMVV--------YQGGTSRTNNLETGPSTRLFQVQGTGAN-NTKAFEV 533
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEPE 603
+N L +DVFVL+T S Y+W GK E+E A K V + + + VV +G EP
Sbjct: 534 PARANFLNSNDVFVLKTQSCCYLWCGKGCSGDEREMA-KMVADTISRTEKQVVVEGQEPA 592
Query: 604 EFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSE 663
FW ALGG + P A GR ++ +F+Q DL E
Sbjct: 593 NFWMALGG-----KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEI-PDFNQDDLEE 646
Query: 664 DGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPR 723
D V++LD ++++FW G E K + ++Y++ R ++ ++V VKQG EP
Sbjct: 647 DDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIV-VKQGHEPP 705
Query: 724 VFKKLFPDWDDGMWSKLSSYEDMK 747
F F WD WS SYED+K
Sbjct: 706 TFTGWFLAWDPFKWSNTKSYEDLK 729
>BC021090-1|AAH21090.1| 715|Homo sapiens SCIN protein protein.
Length = 715
Score = 351 bits (863), Expect = 5e-96
Identities = 228/741 (30%), Positives = 359/741 (48%), Gaps = 44/741 (5%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F AG QAG+++W IE E VP +G FY GD+Y+VL T + S T+ HFWLG +
Sbjct: 10 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYRLHFWLGKE 69
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
+QD+ +AAI+T+ +DD LGG+ V +RE+QG+ES+ F+SYFK ++Y GG S
Sbjct: 70 CSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKG-----GLKYKAGGVAS 124
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G N V TN KRLL + G +R EV S K CFI++ +I+
Sbjct: 125 GLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNK 184
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGS--MDELVSDDTSE 243
+R K VA +R E GR+ + +++E S ++ + LG D DD
Sbjct: 185 YERLKANQVATGIRYNERKGRSELIVVEEGSEPSEL---IKVLGEKPELPDGGDDDDIIA 241
Query: 244 SYTRSDISAVYLYKVLDGDEQ-ELVSMNKPYKQKHLASDAMYILDTGDT-GVYIWLGSDL 301
+ ++ +Y+ G + +V+ P+ L S+ +ILD G +++W G D
Sbjct: 242 DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDA 301
Query: 302 DADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGII 360
+ ++ + A ++L+ Y + + EG E+ FKQ+F +W D ++ G + +
Sbjct: 302 NPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYV 361
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
+E + + S + A+ M D G G + + R+ + D+ G
Sbjct: 362 TEKVAQIKQIPFDASKLHS---SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE 418
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y+I Y Y ++Y W G+ A+ D+ L QL+ L G +
Sbjct: 419 --FYGGDCYIILYTYPR-----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQI 471
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYE--EDQTRLFRVEGTETGVDM 538
+V QGKE H LS+FK +++ Y+ SKK + TRLF+V +
Sbjct: 472 RVSQGKEPVHLLSLFKDKPLII-------YKNGTSKKGGQAPAPPTRLFQVRRNLASI-T 523
Query: 539 RAVQVAEESNVLEDDDVFVLE--TGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVV 596
R V+V ++N L +DVFVL+ SG Y+W GK + QE+E ++V +V+K K + +
Sbjct: 524 RIVEVDVDANSLNSNDVFVLKLPQNSG-YIWVGKGAS-QEEEKGAEYVASVLKCKTLR-I 580
Query: 597 EQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEF 656
++G+EPEEFW +LGG + + P GR E++ EF
Sbjct: 581 QEGEEPEEFWNSLGGKKDYQTSP-----LLETQAEDHPPRLYGCSNKTGRFVIEEIPGEF 635
Query: 657 SQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTV 716
+Q DL+ED V +LD E+++ W G D E K + K Y+E D R + +V+ +
Sbjct: 636 TQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI-I 694
Query: 717 KQGAEPRVFKKLFPDWDDGMW 737
KQG EP F F WD W
Sbjct: 695 KQGHEPPTFTGWFLGWDSSKW 715
>X12901-1|CAA31386.1| 827|Homo sapiens protein ( Human mRNA for
villin. ).
Length = 827
Score = 351 bits (862), Expect = 7e-96
Identities = 237/749 (31%), Positives = 372/749 (49%), Gaps = 52/749 (6%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G++IW IE + VP +G F++GD YI+L + +SSL++D H+W+G ++ D++G+
Sbjct: 18 GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQGA 77
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
AAI+T +DD L GRAV HREVQG+ES F YFK L IR +GG SG V+TN
Sbjct: 78 AAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQ---GLVIR--KGGVASGMKHVETN 132
Query: 134 AGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKI-- 191
+ +RLL + G N+ EV S + F+L+ ++ G ++T+ ++
Sbjct: 133 SYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGK--LIIQWNGPESTRMERLRG 190
Query: 192 ISVANKLRDEEHNGRATIEIID---EFSSDEDVNLFFETLGS-GSMDELVSDDTSESYTR 247
+++A ++RD+E GR + ++D E +S + + + LG + V D E +
Sbjct: 191 MTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALK 250
Query: 248 SDISAVYLYKVLDGDEQELVS--MNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADV 305
+A+ LY V D + +V +P Q L+ + YILD G +Y+W G +
Sbjct: 251 ---AALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQE 307
Query: 306 KRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWD-TVRTGGSVR----GII 360
K+ A +++ K YP V ++GAES+ F+Q F W + RT G + G +
Sbjct: 308 KKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSV 367
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
++++ F A + + A+ M D G G + V RI + D G
Sbjct: 368 AKVEQVKFD-------ATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH 420
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y++ Y Y E+ +++Y+W GS+AS D+ A L++ G +
Sbjct: 421 --FYGGDCYLLLYTYL-IGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQI 477
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEE--DQTRLFRVEGTETGVDM 538
+VP GKE H +SIFKG +VV YQ S+ + E TRLF+V+GT +
Sbjct: 478 RVPMGKEPPHLMSIFKGRMVV--------YQGGTSRTNNLETGPSTRLFQVQGTGAN-NT 528
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQ 598
+A +V +N L +DVFVL+T S Y+W GK E+E A K V + + + VV +
Sbjct: 529 KAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSGDEREMA-KMVADTISRTEKQVVVE 587
Query: 599 GDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQ 658
G EP FW ALGG + P A GR ++ +F+Q
Sbjct: 588 GQEPANFWMALGG-----KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEI-PDFNQ 641
Query: 659 QDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQ 718
DL ED V++LD ++++FW G E K + ++Y++ R ++ ++V VKQ
Sbjct: 642 DDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIV-VKQ 700
Query: 719 GAEPRVFKKLFPDWDDGMWSKLSSYEDMK 747
G EP F F WD WS SYED+K
Sbjct: 701 GHEPPTFTGWFLAWDPFKWSNTKSYEDLK 729
>AK075123-1|BAC11416.1| 715|Homo sapiens protein ( Homo sapiens
cDNA FLJ90642 fis, clone PLACE1004078, highly similar to
Bovine mRNA for adseverin. ).
Length = 715
Score = 350 bits (861), Expect = 9e-96
Identities = 227/741 (30%), Positives = 359/741 (48%), Gaps = 44/741 (5%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F AG QAG+++W IE E VP +G FY GD+Y++L T + S T+ HFWLG +
Sbjct: 10 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLMLHTAKTSRGFTYHLHFWLGKE 69
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
+QD+ +AAI+T+ +DD LGG+ V +RE+QG+ES+ F+SYFK ++Y GG S
Sbjct: 70 CSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKG-----GLKYKAGGVAS 124
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G N V TN KRLL + G +R EV S K CFI++ +I+
Sbjct: 125 GLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNK 184
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGS--MDELVSDDTSE 243
+R K VA +R E GR+ + +++E S ++ + LG D DD
Sbjct: 185 YERLKANQVATGIRYNERKGRSELIVVEEGSEPSEL---IKVLGEKPELPDGGDDDDIIA 241
Query: 244 SYTRSDISAVYLYKVLDGDEQ-ELVSMNKPYKQKHLASDAMYILDTGDT-GVYIWLGSDL 301
+ ++ +Y+ G + +V+ P+ L S+ +ILD G +++W G D
Sbjct: 242 DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDA 301
Query: 302 DADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGII 360
+ ++ + A ++L+ Y + + EG E+ FKQ+F +W D ++ G + +
Sbjct: 302 NPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYV 361
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
+E + + S + A+ M D G G + + R+ + D+ G
Sbjct: 362 TEKVAQIKQIPFDASKLHS---SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE 418
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y+I Y Y ++Y W G+ A+ D+ L QL+ L G +
Sbjct: 419 --FYGGDCYIILYTYPR-----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQI 471
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYE--EDQTRLFRVEGTETGVDM 538
+V QGKE H LS+FK +++ Y+ SKK + TRLF+V +
Sbjct: 472 RVSQGKEPVHLLSLFKDKPLII-------YKNGTSKKGGQAPAPPTRLFQVRRNLASI-T 523
Query: 539 RAVQVAEESNVLEDDDVFVLE--TGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVV 596
R V+V ++N L +DVFVL+ SG Y+W GK + QE+E ++V +V+K K + +
Sbjct: 524 RIVEVDVDANSLNSNDVFVLKLPQNSG-YIWVGKGAS-QEEEKGAEYVASVLKCKTLR-I 580
Query: 597 EQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEF 656
++G+EPEEFW +LGG + + P GR E++ EF
Sbjct: 581 QEGEEPEEFWNSLGGKKDYQTSP-----LLETQAEDHPPRLYGCSNKTGRFVIEEIPGEF 635
Query: 657 SQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTV 716
+Q DL+ED V +LD E+++ W G D E K + K Y+E D R + +V+ +
Sbjct: 636 TQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI-I 694
Query: 717 KQGAEPRVFKKLFPDWDDGMW 737
KQG EP F F WD W
Sbjct: 695 KQGHEPPTFTGWFLGWDSSKW 715
>AF276507-1|AAK60494.1| 715|Homo sapiens scinderin protein.
Length = 715
Score = 349 bits (858), Expect = 2e-95
Identities = 225/740 (30%), Positives = 358/740 (48%), Gaps = 42/740 (5%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F AG QAG+++W IE E VP +G FY GD+Y+VL T + S T+ HFWLG +
Sbjct: 10 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKE 69
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
+QD+ +AAI+T+ +DD LGG+ V +RE+QG+ES+ F+SYFK ++Y GG S
Sbjct: 70 CSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKG-----GLKYKAGGVAS 124
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G N V TN KRLL + G +R EV S K CFI++ +I+
Sbjct: 125 GLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNK 184
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGS--MDELVSDDTSE 243
+R K VA +R E GR+ + +++E S ++ + LG D DD
Sbjct: 185 YERLKANQVATGIRYNERKGRSELIVVEEGSEPSEL---IKVLGEKPELPDGGDDDDIIA 241
Query: 244 SYTRSDISAVYLYKVLDGDEQ-ELVSMNKPYKQKHLASDAMYILDTGDT-GVYIWLGSDL 301
+ ++ +Y+ G + +V+ P+ L S+ +ILD G +++W G D
Sbjct: 242 DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDA 301
Query: 302 DADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGII 360
+ ++ + A ++L+ Y + + EG E+ FKQ+F +W D ++ G + +
Sbjct: 302 NPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYV 361
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
+E + + S + A+ M D G G + + R+ + D+ G
Sbjct: 362 TEKVAQIKQIPFDASKLHS---SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE 418
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y+I Y Y ++Y W G+ A+ D+ L QL+ L G +
Sbjct: 419 --FYGGDCYIILYTYPR-----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQI 471
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYE--EDQTRLFRVEGTETGVDM 538
+V Q KE H LS+FK +++ Y+ SKK + TRLF+V +
Sbjct: 472 RVSQDKEPVHLLSLFKDKPLII-------YKNGTSKKGGQAPAPPTRLFQVRRNLASI-T 523
Query: 539 RAVQVAEESNVLEDDDVFVLE-TGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVE 597
R V+V ++N L +DVFVL+ + + Y+W GK + QE+E ++V +V+K K + ++
Sbjct: 524 RIVEVDVDANSLNSNDVFVLKLSQNSGYIWVGKGAS-QEEEKGAEYVASVLKCKTLR-IQ 581
Query: 598 QGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFS 657
+G+EPEEFW +LGG + + P GR E++ EF+
Sbjct: 582 EGEEPEEFWNSLGGKKDYQTSP-----LLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFT 636
Query: 658 QQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVK 717
Q DL+ED V +LD E+++ W G D E K + K Y+E D R + +V+ +K
Sbjct: 637 QDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI-IK 695
Query: 718 QGAEPRVFKKLFPDWDDGMW 737
QG EP F F WD W
Sbjct: 696 QGHEPPTFTGWFLGWDSSKW 715
>AF041449-1|AAC25051.1| 819|Homo sapiens advillin protein.
Length = 819
Score = 344 bits (845), Expect = 8e-94
Identities = 231/749 (30%), Positives = 352/749 (46%), Gaps = 36/749 (4%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F N GI +W IE E +G FY GD Y++L T +S L+ D HFW+G
Sbjct: 7 FRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKD 66
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
++QD++ AAI+T LDD LGG V HREVQ HES F YFK I Y +GG S
Sbjct: 67 SSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQ-----GIIYKQGGVAS 121
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G V+TN KRLL + G N+R EV S + F+L+ I + +
Sbjct: 122 GMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNS 181
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIID---EFSSDEDVNLFFETLGSGSMDELVSDDTS 242
+R K + +A +RD E GRA I +I+ E +S E + + +TLG S+ + D
Sbjct: 182 GERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPD-- 239
Query: 243 ESYTRSDISAVYLYKVLDGDEQELVS--MNKPYKQKHLASDAMYILDTGDTGVYIWLGSD 300
E + S + LY + D Q V+ +P Q L D YILD T +Y+W G
Sbjct: 240 EIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKG 299
Query: 301 LDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVRTGGSVRGII 360
K+ A +++ K YPS +V V++GAES+ FKQ F W G+
Sbjct: 300 ATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWS---VKDQTMGLG 356
Query: 361 SEIDSGYFSGDAEESAAAARTIGK-SATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQG 419
G + ++ K A+ M D G G + V RI + ++ Q
Sbjct: 357 KTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRI--ENLELVPVEYQW 414
Query: 420 TSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTS 479
Y + Y++ Y Y+ N + ++Y+W AS D+ A +++ +G
Sbjct: 415 YGFFYGGDCYLVLYTYE-VNGKPHHILYIWQDRHASQDELAASAYQAVEVDRQFDGAAVQ 473
Query: 480 VKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEED-QTRLFRVEGTETGVDM 538
V+V G E +HF++IFKG LV+ G + K + E D RLF++ G + +
Sbjct: 474 VRVRMGTEPRHFMAIFKGKLVIFEGG-------TSRKGNAEPDPPVRLFQIHGNDKS-NT 525
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQ 598
+AV+V ++ L +DVF+L T + Y+W GK S E+ A K + +++ D V +
Sbjct: 526 KAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDER-AMAKELASLLCDGSENTVAE 584
Query: 599 GDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQ 658
G EP EFW+ LGG + P A G+ ++ T+F+Q
Sbjct: 585 GQEPAEFWDLLGG-----KTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEI-TDFTQ 638
Query: 659 QDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQ 718
DL+ V +LDT ++++ W GA+ K S ++Y+ R D+ +++ +KQ
Sbjct: 639 DDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILI-IKQ 697
Query: 719 GAEPRVFKKLFPDWDDGMWSKLSSYEDMK 747
G EP +F F WD +WS +YE +K
Sbjct: 698 GFEPPIFTGWFLAWDPNIWSAGKTYEQLK 726
>BC111730-1|AAI11731.1| 812|Homo sapiens AVIL protein protein.
Length = 812
Score = 336 bits (827), Expect = 1e-91
Identities = 229/745 (30%), Positives = 351/745 (47%), Gaps = 37/745 (4%)
Query: 10 GNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQD 69
G+ +IW E E +G FY GD Y++L T +S L+ D HFW+G ++QD
Sbjct: 5 GHPGSYKIWG-EKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSSQD 63
Query: 70 KKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNE 129
++ AAI+T LDD LGG V HREVQ HES F YFK I Y +GG SG
Sbjct: 64 EQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQ-----GIIYKQGGVASGMKH 118
Query: 130 VQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRR 189
V+TN KRLL + G N+R EV S + F+L+ I + + +R
Sbjct: 119 VETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERL 178
Query: 190 KIISVANKLRDEEHNGRATIEIID---EFSSDEDVNLFFETLGSGSMDELVSDDTSESYT 246
K + +A +RD E GRA I +I+ E +S E + + +TLG S+ + D E
Sbjct: 179 KAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPD--EIID 236
Query: 247 RSDISAVYLYKVLDGDEQELVS--MNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDAD 304
+ S + LY + D Q V+ +P Q L D YILD T +Y+W G
Sbjct: 237 QKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKA 296
Query: 305 VKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVRTGGSVRGIISEID 364
K+ A +++ K YPS +V V++GAES+ FKQ F W G+
Sbjct: 297 EKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWS---VKDQTMGLGKTFS 353
Query: 365 SGYFSGDAEESAAAARTIGK-SATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGTSVL 423
G + ++ K A+ M D G G + V RI + ++ Q
Sbjct: 354 IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRI--ENLELVPVEYQWYGFF 411
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y + Y++ Y Y+ N + ++Y+W G AS D+ A +++ +G V+V
Sbjct: 412 YGGDCYLVLYTYE-VNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVR 470
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEED-QTRLFRVEGTETGVDMRAVQ 542
G E +HF++IFKG LV+ G + K + E D RLF++ G + + +AV+
Sbjct: 471 MGTEPRHFMAIFKGKLVIFEGG-------TSRKGNAEPDPPVRLFQIHGNDKS-NTKAVE 522
Query: 543 VAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEP 602
V ++ L +DVF+L T + Y+W GK S E+ A K + +++ D V +G EP
Sbjct: 523 VPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDER-AMAKELASLLCDGSENTVAEGQEP 581
Query: 603 EEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLS 662
EFW+ LGG + P A G+ ++ T+F+Q DL+
Sbjct: 582 AEFWDLLGG-----KTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTEI-TDFTQDDLN 635
Query: 663 EDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEP 722
V +LDT ++++ W GA+ K S ++Y+ R D+ +++ +KQG EP
Sbjct: 636 PTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILI-IKQGFEP 694
Query: 723 RVFKKLFPDWDDGMWSKLSSYEDMK 747
+F F WD +WS +YE +K
Sbjct: 695 PIFTGWFLAWDPNIWSAGKTYEQLK 719
>AC005281-1|AAD15423.1| 527|Homo sapiens WUGSC:H_DJ0722F20.1
protein.
Length = 527
Score = 245 bits (599), Expect = 5e-64
Identities = 150/503 (29%), Positives = 244/503 (48%), Gaps = 23/503 (4%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F AG QAG+++W IE E VP +G FY GD+Y+VL T + S T+ HFWLG +
Sbjct: 10 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKE 69
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
+QD+ +AAI+T+ +DD LGG+ V +RE+QG+ES+ F+SYFK ++Y GG S
Sbjct: 70 CSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKG-----GLKYKAGGVAS 124
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G N V TN KRLL + G +R EV S K CFI++ +I+
Sbjct: 125 GLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNK 184
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGS--MDELVSDDTSE 243
+R K VA +R E GR+ + +++E S ++ + LG D DD
Sbjct: 185 YERLKANQVATGIRYNERKGRSELIVVEEGSEPSEL---IKVLGEKPELPDGGDDDDIIA 241
Query: 244 SYTRSDISAVYLYKVLDGDEQ-ELVSMNKPYKQKHLASDAMYILDTGDT-GVYIWLGSDL 301
+ ++ +Y+ G + +V+ P+ L S+ +ILD G +++W G D
Sbjct: 242 DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDA 301
Query: 302 DADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGII 360
+ ++ + A ++L+ Y + + EG E+ FKQ+F +W D ++ G + +
Sbjct: 302 NPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYV 361
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
+E + + S + A+ M D G G + + R+ + D+ G
Sbjct: 362 TEKVAQIKQIPFDASKLHS---SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE 418
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y+I Y Y ++Y W G+ A+ D+ L QL+ L G +
Sbjct: 419 --FYGGDCYIILYTYPR-----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQI 471
Query: 481 KVPQGKESKHFLSIFKGSLVVLF 503
+V QGKE H LS+FK ++++
Sbjct: 472 RVSQGKEPVHLLSLFKDKPLIIY 494
Score = 89.4 bits (212), Expect = 4e-17
Identities = 71/319 (22%), Positives = 132/319 (41%), Gaps = 18/319 (5%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y + Y++ + + + + ++ W+G E S D+ A + Q+++ L G +
Sbjct: 41 YVGDAYLVLHTAKT-SRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNREL 99
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
QG ES F+S FKG L G N + + RL V+G +RA +V
Sbjct: 100 QGYESNDFVSYFKGGLKYKAGGVASGL---NHVLTNDLTAKRLLHVKGRRV---VRATEV 153
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ D F+++ G+ +Y W G + E+ A + + ++ ++ VVE+
Sbjct: 154 PLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEE 213
Query: 599 GDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAG-RVKFEDLDTEFS 657
G EP E + LG PE + S RV + FS
Sbjct: 214 GSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFS 273
Query: 658 QQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVT 715
L + +ILD G ++++ W+G D + + + + +++++ + V+
Sbjct: 274 MAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVL-- 331
Query: 716 VKQGAEPRVFKKLFPDWDD 734
+G E +FK+ F DW D
Sbjct: 332 -PEGGETPIFKQFFKDWRD 349
Score = 33.1 bits (72), Expect = 3.7
Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 18/181 (9%)
Query: 564 VYVWNGKDSDPQEQEAALKF---VENVVKDKDVTVVE-QGDEPEEFWEALGGIPEEKEEP 619
++ W GK+ E AA F +++ + K V E QG E +F G + K
Sbjct: 62 LHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYK--- 118
Query: 620 SAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYILDTGEELYFWQ 679
+ + V GR + S ++ +I+D G E+Y W
Sbjct: 119 AGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWC 178
Query: 680 GADVT--ERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPRVFKKLF---PDWDD 734
G+ ER+K+++ +Y E G + ++ V++G+EP K+ P+ D
Sbjct: 179 GSSCNKYERLKANQVATGIRYNERKG------RSELIVVEEGSEPSELIKVLGEKPELPD 232
Query: 735 G 735
G
Sbjct: 233 G 233
>AB067492-1|BAB67798.1| 626|Homo sapiens KIAA1905 protein protein.
Length = 626
Score = 245 bits (599), Expect = 5e-64
Identities = 150/503 (29%), Positives = 244/503 (48%), Gaps = 23/503 (4%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSK 65
F AG QAG+++W IE E VP +G FY GD+Y+VL T + S T+ HFWLG +
Sbjct: 56 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKE 115
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
+QD+ +AAI+T+ +DD LGG+ V +RE+QG+ES+ F+SYFK ++Y GG S
Sbjct: 116 CSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKG-----GLKYKAGGVAS 170
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
G N V TN KRLL + G +R EV S K CFI++ +I+
Sbjct: 171 GLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNK 230
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGS--MDELVSDDTSE 243
+R K VA +R E GR+ + +++E S ++ + LG D DD
Sbjct: 231 YERLKANQVATGIRYNERKGRSELIVVEEGSEPSEL---IKVLGEKPELPDGGDDDDIIA 287
Query: 244 SYTRSDISAVYLYKVLDGDEQ-ELVSMNKPYKQKHLASDAMYILDTGDT-GVYIWLGSDL 301
+ ++ +Y+ G + +V+ P+ L S+ +ILD G +++W G D
Sbjct: 288 DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDA 347
Query: 302 DADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGII 360
+ ++ + A ++L+ Y + + EG E+ FKQ+F +W D ++ G + +
Sbjct: 348 NPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYV 407
Query: 361 SEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGT 420
+E + + S + A+ M D G G + + R+ + D+ G
Sbjct: 408 TEKVAQIKQIPFDASKLHS---SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE 464
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
Y + Y+I Y Y ++Y W G+ A+ D+ L QL+ L G +
Sbjct: 465 --FYGGDCYIILYTYPR-----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQI 517
Query: 481 KVPQGKESKHFLSIFKGSLVVLF 503
+V QGKE H LS+FK ++++
Sbjct: 518 RVSQGKEPVHLLSLFKDKPLIIY 540
Score = 89.4 bits (212), Expect = 4e-17
Identities = 71/319 (22%), Positives = 132/319 (41%), Gaps = 18/319 (5%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y + Y++ + + + + ++ W+G E S D+ A + Q+++ L G +
Sbjct: 87 YVGDAYLVLHTAKT-SRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNREL 145
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
QG ES F+S FKG L G N + + RL V+G +RA +V
Sbjct: 146 QGYESNDFVSYFKGGLKYKAGGVASGL---NHVLTNDLTAKRLLHVKGRRV---VRATEV 199
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ D F+++ G+ +Y W G + E+ A + + ++ ++ VVE+
Sbjct: 200 PLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEE 259
Query: 599 GDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAG-RVKFEDLDTEFS 657
G EP E + LG PE + S RV + FS
Sbjct: 260 GSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFS 319
Query: 658 QQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVT 715
L + +ILD G ++++ W+G D + + + + +++++ + V+
Sbjct: 320 MAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVL-- 377
Query: 716 VKQGAEPRVFKKLFPDWDD 734
+G E +FK+ F DW D
Sbjct: 378 -PEGGETPIFKQFFKDWRD 395
Score = 33.1 bits (72), Expect = 3.7
Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 18/181 (9%)
Query: 564 VYVWNGKDSDPQEQEAALKF---VENVVKDKDVTVVE-QGDEPEEFWEALGGIPEEKEEP 619
++ W GK+ E AA F +++ + K V E QG E +F G + K
Sbjct: 108 LHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYK--- 164
Query: 620 SAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYILDTGEELYFWQ 679
+ + V GR + S ++ +I+D G E+Y W
Sbjct: 165 AGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWC 224
Query: 680 GADVT--ERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPRVFKKLF---PDWDD 734
G+ ER+K+++ +Y E G + ++ V++G+EP K+ P+ D
Sbjct: 225 GSSCNKYERLKANQVATGIRYNERKG------RSELIVVEEGSEPSELIKVLGEKPELPD 278
Query: 735 G 735
G
Sbjct: 279 G 279
>AK027778-1|BAB55361.1| 468|Homo sapiens protein ( Homo sapiens
cDNA FLJ14872 fis, clone PLACE1002655, highly similar to
ADSEVERIN. ).
Length = 468
Score = 200 bits (489), Expect = 1e-50
Identities = 137/478 (28%), Positives = 223/478 (46%), Gaps = 33/478 (6%)
Query: 266 LVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRKYHEIAGKYLEDKGYPS 324
+V+ P+ L S+ +ILD G +++W G D + ++ + A ++L+ Y
Sbjct: 18 VVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK 77
Query: 325 WVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGIISEIDSGYFSGDAEESAAAARTIG 383
+ + EG E+ FKQ+F +W D ++ G + ++E + + S +
Sbjct: 78 NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHS---S 134
Query: 384 KSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGTSVLYQSEVYVITYKYQNENEEDA 443
A+ M D G G + + R+ + D+ G Y + Y+I Y Y
Sbjct: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE--FYGGDCYIILYTYPRGQ---- 188
Query: 444 WVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIFKGSLVVLF 503
++Y W G+ A+ D+ L QL+ L G ++V QGKE H LS+FK +++
Sbjct: 189 -IIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLII- 246
Query: 504 GSKDDDYQPQNSKKSYE--EDQTRLFRVEGTETGVDMRAVQVAEESNVLEDDDVFVLE-- 559
Y+ SKK + TRLF+V + R V+V ++N L +DVFVL+
Sbjct: 247 ------YKNGTSKKGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVLKLP 299
Query: 560 TGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEPEEFWEALGGIPEEKEEP 619
SG Y+W GK + QE+E ++V +V+K K + +++G+EPEEFW +LGG + + P
Sbjct: 300 QNSG-YIWVGKGAS-QEEEKGAEYVASVLKCKTLR-IQEGEEPEEFWNSLGGKKDYQTSP 356
Query: 620 SAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYILDTGEELYFWQ 679
GR E++ EF+Q DL+ED V +LD E+++ W
Sbjct: 357 -----LLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWI 411
Query: 680 GADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWDDGMW 737
G D E K + K Y+E D R + +V+ +KQG EP F F WD W
Sbjct: 412 GKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI-IKQGHEPPTFTGWFLGWDSSKW 468
Score = 99 bits (238), Expect = 3e-20
Identities = 93/340 (27%), Positives = 157/340 (46%), Gaps = 30/340 (8%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSA 74
+EIW +EN + D YG+FY GD YI+L T + + W G+ T+D+ ++
Sbjct: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQII----YTWQGANATRDELTTS 206
Query: 75 AIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTNA 134
A T+ LD LGG+AV R QG E LS FK + I Y G ++ G Q A
Sbjct: 207 AFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPL---IIYKNGTSKKG---GQAPA 260
Query: 135 GAEKRL-LKLSGCDNMRIEEVAAEASSLTKNHCFILE-NEHDIFVLMPEGAKATQRRKII 192
+ ++ + RI EV +A+SL N F+L+ ++ ++ + +GA + +
Sbjct: 261 PPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAE 320
Query: 193 SVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISA 252
VA+ L+ + T+ I E+ F+ +LG G D S T+++
Sbjct: 321 YVASVLKCK------TLRI----QEGEEPEEFWNSLG-GKKDYQTSPLLE---TQAEDHP 366
Query: 253 VYLYKVLDGDEQELV-SMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHE 311
LY + + ++ + + Q LA D + +LD + ++IW+G D + K++ +
Sbjct: 367 PRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQ-IFIWIGKDANEVEKKESLK 425
Query: 312 IAGKYLE--DKGYPSWVHVTRVSEGAESSTFKQYFHNWDT 349
A YLE G + + +G E TF +F WD+
Sbjct: 426 SAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDS 465
>BC000243-1|AAH00243.1| 686|Homo sapiens VILL protein protein.
Length = 686
Score = 195 bits (476), Expect = 4e-49
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 46/581 (7%)
Query: 186 TQRRKIISVANKLRDEEHNG-RATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSES 244
+++ + +++ LRD E G RA I ++D+ + D+ E + + L + S+
Sbjct: 13 SEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKD 72
Query: 245 YTRSDISAVYLYKVLD-GDEQELVSM-NKPYKQKHLASDAMYILDTGDTGVYIWLGSDLD 302
+ + V LY V + G + ++ + P Q L + YILD G +Y+W G
Sbjct: 73 INQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSS 132
Query: 303 ADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR-----TGGSVR 357
++ A +++ KGYP++ +V V++GAES+ FKQ F W R GG +
Sbjct: 133 LQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDK 192
Query: 358 GIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQ 417
I ++D G T K A A+ M D G G + V I D +
Sbjct: 193 SIHVKLDVG-----------KLHTQPKLA-AQLRMVDDGSGKVEVWCIQDLHRQPVDPKR 240
Query: 418 QGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNV 477
G L Y++ Y YQ +++YLW G +A+ D+ EA +L+ G +
Sbjct: 241 HGQ--LCAGNCYLVLYTYQRLGRVQ-YILYLWQGHQATADEIEALNSNAEELDVMYGGVL 297
Query: 478 TSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVD 537
V G E HFL+IF+G LV+ + + K TRLF+V+GT++ +
Sbjct: 298 VQEHVTMGSEPPHFLAIFQGQLVIF------QERAGHHGKGQSASTTRLFQVQGTDSH-N 350
Query: 538 MRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVE 597
R ++V ++ L D+F+L T S Y+W GK + ++E A + V V+ K+ V
Sbjct: 351 TRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMA-RVVVTVISRKNEETVL 409
Query: 598 QGDEPEEFWEALGG---IPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
+G EP FWEALGG P K P V V F
Sbjct: 410 EGQEPPHFWEALGGRAPYPSNKRLPE---EVPSFQPRLFECSSHMGCLVLAEVGF----- 461
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
FSQ+DL + + +LDT +E++ W G +E ++ ++Y++ R+ + +V
Sbjct: 462 -FSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWG--QEYLKTHPAGRS-PATPIV 517
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWSKLSSYEDMKNSTKAANS 755
VKQG EP F F WD W+ S++++ + + AA S
Sbjct: 518 LVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAAS 558
Score = 71.3 bits (167), Expect = 1e-11
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 13/192 (6%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSA 74
+E+W I++ P DPK +G+ G+ Y+VL T + + + + W G + T D+ +
Sbjct: 223 VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEAL 282
Query: 75 AIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTNA 134
LD M GG V G E FL+ F+ L I G+ T
Sbjct: 283 NSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQG---QLVIFQERAGHHGKGQSASTT- 338
Query: 135 GAEKRLLKLSGCD--NMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQR---R 189
RL ++ G D N R EV A ASSL + F+L ++ +G QR R
Sbjct: 339 ----RLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMAR 394
Query: 190 KIISVANKLRDE 201
+++V ++ +E
Sbjct: 395 VVVTVISRKNEE 406
>D88154-1|BAA21668.1| 686|Homo sapiens villin-like protein protein.
Length = 686
Score = 195 bits (475), Expect = 6e-49
Identities = 161/581 (27%), Positives = 263/581 (45%), Gaps = 46/581 (7%)
Query: 186 TQRRKIISVANKLRDEEHNG-RATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSES 244
+++ + +++ LRD E G RA I ++D+ + D+ E + + L + S+
Sbjct: 13 SEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGCRVGSLRAATPSKD 72
Query: 245 YTRSDISAVYLYKVLD-GDEQELVSM-NKPYKQKHLASDAMYILDTGDTGVYIWLGSDLD 302
+ + V LY V + G + ++ + P Q L + YILD G +Y+W G
Sbjct: 73 INQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSS 132
Query: 303 ADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR-----TGGSVR 357
++ A +++ KGYP++ +V V++GAES+ FKQ F W R GG +
Sbjct: 133 LQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDK 192
Query: 358 GIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQ 417
I ++D G T K A A+ M D G G + V I D +
Sbjct: 193 SIHVKLDVG-----------KLHTQPKLA-AQLRMVDDGSGKVEVWCIQDLHRQPVDPKR 240
Query: 418 QGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNV 477
G L Y++ Y YQ +++YLW G +A+ D+ EA +L+ G +
Sbjct: 241 HGQ--LCAGNCYLVLYTYQRLGRVQ-YILYLWQGHQATADEIEALNSNAEELDVMYGGVL 297
Query: 478 TSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVD 537
V G E HFL+IF+G LV+ + + K TRLF+V+GT++ +
Sbjct: 298 VQEHVTMGSEPPHFLAIFQGQLVIF------QERAGHHGKGQSASTTRLFQVQGTDSH-N 350
Query: 538 MRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVE 597
R ++V ++ L D+F+L T S Y+W GK + ++E A + V V+ K+ V
Sbjct: 351 TRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMA-RVVVTVISRKNEETVL 409
Query: 598 QGDEPEEFWEALGG---IPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDT 654
+G EP FWEALGG P K P V V F
Sbjct: 410 EGQEPPHFWEALGGRAPYPSNKRLPE---EVPSFQPRLFECSSHMGCLVLAEVGF----- 461
Query: 655 EFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVV 714
FSQ+DL + + +LDT +E++ W G +E ++ ++Y++ R+ + +V
Sbjct: 462 -FSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWG--QEYLKTHPAGRS-PATPIV 517
Query: 715 TVKQGAEPRVFKKLFPDWDDGMWSKLSSYEDMKNSTKAANS 755
VKQG EP F F WD W+ S++++ + + AA S
Sbjct: 518 LVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAAS 558
Score = 71.3 bits (167), Expect = 1e-11
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 13/192 (6%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSA 74
+E+W I++ P DPK +G+ G+ Y+VL T + + + + W G + T D+ +
Sbjct: 223 VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEAL 282
Query: 75 AIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTNA 134
LD M GG V G E FL+ F+ L I G+ T
Sbjct: 283 NSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQG---QLVIFQERAGHHGKGQSASTT- 338
Query: 135 GAEKRLLKLSGCD--NMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQR---R 189
RL ++ G D N R EV A ASSL + F+L ++ +G QR R
Sbjct: 339 ----RLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMAR 394
Query: 190 KIISVANKLRDE 201
+++V ++ +E
Sbjct: 395 VVVTVISRKNEE 406
>AL513122-7|CAI14416.1| 485|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 485
Score = 190 bits (463), Expect = 2e-47
Identities = 129/440 (29%), Positives = 207/440 (47%), Gaps = 23/440 (5%)
Query: 255 LYKVLDGD---EQELVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRKYH 310
LYKV +G LV+ P+ Q L S+ +ILD G G +++W G + + ++
Sbjct: 31 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 90
Query: 311 EIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGIISEIDSGYFS 369
+ A ++ YP V+ + EG E+ FKQ+F NW D +T G +S + S +
Sbjct: 91 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLG---LSYLSSHIAN 147
Query: 370 GDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGTSVLYQSEVY 429
+ AA + A+ M D G G + RI G + D G Y + Y
Sbjct: 148 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQ--FYGGDSY 205
Query: 430 VITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESK 489
+I Y Y++ + ++Y W G++++ D+ A +L +QL+E+L G +V QGKE
Sbjct: 206 IILYNYRHGGRQGQ-IIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPA 264
Query: 490 HFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNV 549
H +S+F G ++++ Q + S TRLF+V G RAV+V ++
Sbjct: 265 HLMSLFGGKPMIIYKGGTSREGGQTAPAS-----TRLFQVRANSAGA-TRAVEVLPKAGA 318
Query: 550 LEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEPEEFWEAL 609
L +D FVL+T S Y+W G + E+ A + + V++ + V V E G EP+ FWEAL
Sbjct: 319 LNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAE-GSEPDGFWEAL 376
Query: 610 GGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYIL 669
GG + P GR E++ E Q+DL+ D V +L
Sbjct: 377 GGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLL 432
Query: 670 DTGEELYFWQGADVTERVKS 689
DT ++++ W G D E K+
Sbjct: 433 DTWDQVFVWVGKDSQEEEKT 452
Score = 97.9 bits (233), Expect = 1e-19
Identities = 85/296 (28%), Positives = 135/296 (45%), Gaps = 28/296 (9%)
Query: 16 EIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSAA 75
+IW IE VP DP YG+FY GDSYI+L + W G+++TQD+ ++A
Sbjct: 179 QIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASA 238
Query: 76 IWTITLDDMLGGRAVHHREVQGHESSLFLSYF--KPVSIHLAIRYLEGGNESGFNEVQTN 133
I T LD+ LGG V R VQG E + +S F KP+ I+ EGG QT
Sbjct: 239 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGG--------QT- 289
Query: 134 AGAEKRL--LKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKI 191
A A RL ++ + R EV +A +L N F+L+ ++ + GA ++
Sbjct: 290 APASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGA 349
Query: 192 ISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDIS 251
+ LR + +++ + D F+E LG G S + + D
Sbjct: 350 QELLRVLRAQ------PVQVAEGSEPDG----FWEALG-GKAAYRTSPRLKDK--KMDAH 396
Query: 252 AVYLYKVLDGDEQELV-SMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVK 306
L+ + + ++ + Q+ LA+D + +LDT D V++W+G D + K
Sbjct: 397 PPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQ-VFVWVGKDSQEEEK 451
Score = 46.8 bits (106), Expect = 3e-04
Identities = 43/149 (28%), Positives = 59/149 (39%), Gaps = 19/149 (12%)
Query: 439 NEEDAWVV------YLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFL 492
N DA+V+ YLW+G+ AS+ +K Q LL L V+V +G E F
Sbjct: 320 NSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQ------PVQVAEGSEPDGFW 373
Query: 493 SIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLED 552
G P+ K + RLF + V L
Sbjct: 374 EALGGKAAYRTS-------PRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLAT 426
Query: 553 DDVFVLETGSGVYVWNGKDSDPQEQEAAL 581
DDV +L+T V+VW GKDS +E+ AL
Sbjct: 427 DDVMLLDTWDQVFVWVGKDSQEEEKTEAL 455
Score = 34.3 bits (75), Expect = 1.6
Identities = 20/84 (23%), Positives = 40/84 (47%), Gaps = 5/84 (5%)
Query: 653 DTEFSQQDLSEDGVYILDTGEE--LYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDS 710
+ F+Q L + +ILD G++ ++ W+G + + + +I +D +
Sbjct: 49 ENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITK--MDYPKQT 106
Query: 711 AVVVTVKQGAEPRVFKKLFPDWDD 734
V V + +G E +FK+ F +W D
Sbjct: 107 QVSV-LPEGGETPLFKQFFKNWRD 129
>BC017303-1|AAH17303.1| 421|Homo sapiens VIL1 protein protein.
Length = 421
Score = 188 bits (459), Expect = 5e-47
Identities = 116/350 (33%), Positives = 187/350 (53%), Gaps = 19/350 (5%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G++IW IE + VP +G F++GD YI+L + +SSL++D H+W+G ++ D++G+
Sbjct: 18 GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQGA 77
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
AAI+T +DD L GRAV HREVQG+ES F YFK L IR +GG SG V+TN
Sbjct: 78 AAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQ---GLVIR--KGGVASGMKHVETN 132
Query: 134 AGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKI-- 191
+ +RLL + G N+ EV S + F+L+ ++ G ++T+ ++
Sbjct: 133 SYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGK--LIIQWNGPESTRMERLRG 190
Query: 192 ISVANKLRDEEHNGRATIEIID---EFSSDEDVNLFFETLGS-GSMDELVSDDTSESYTR 247
+++A ++RD+E GR + ++D E +S + + + LG + V D E +
Sbjct: 191 MTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALK 250
Query: 248 SDISAVYLYKVLDGDEQELVS--MNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADV 305
+A+ LY V D + +V +P Q L+ + YILD G +Y+W G +
Sbjct: 251 ---AALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQE 307
Query: 306 KRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWD-TVRTGG 354
K+ A +++ K YP V ++GAES+ F+Q F W + RT G
Sbjct: 308 KKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSG 357
Score = 77.0 bits (181), Expect = 2e-13
Identities = 77/320 (24%), Positives = 136/320 (42%), Gaps = 22/320 (6%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
+ + Y+I ++ + ++ ++ WIG ++S D++ A + +Q+++ L+G +
Sbjct: 41 FDGDCYIILAIHKTASSL-SYDIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREV 99
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
QG ES+ F FK LV+ G + + SY D RL V+G V A +V
Sbjct: 100 QGNESEAFRGYFKQGLVIRKGGVASGMKHVET-NSY--DVQRLLHVKGKRNVV---AGEV 153
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKD------VTVVE 597
DVF+L+ G + WNG +S E+ + + ++D++ V VV+
Sbjct: 154 EMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKE-IRDQERGGRTYVGVVD 212
Query: 598 QGDE--PEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVA-GRVKFEDLDT 654
+E + E + + ++ E A V + G + ++ T
Sbjct: 213 GENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVAT 272
Query: 655 EFSQQD-LSEDGVYILDTGE-ELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAV 712
QD LS + YILD G ++Y W+G E+ K +I+ + S
Sbjct: 273 RPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMSHALNFIK---AKQYPPSTQ 329
Query: 713 VVTVKQGAEPRVFKKLFPDW 732
V GAE VF++LF W
Sbjct: 330 VEVQNDGAESAVFQQLFQKW 349
>BC004300-1|AAH04300.1| 672|Homo sapiens VILL protein protein.
Length = 672
Score = 184 bits (448), Expect = 1e-45
Identities = 158/579 (27%), Positives = 257/579 (44%), Gaps = 56/579 (9%)
Query: 186 TQRRKIISVANKLRDEEHNG-RATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSES 244
+++ + +++ LRD E G RA I ++D+ + D+ E + + L + S+
Sbjct: 13 SEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKD 72
Query: 245 YTRSDISAVYLYKVLDGDEQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDAD 304
+ + V LY V + + L + YILD G +Y+W G
Sbjct: 73 INQLQKANVRLYHVYEKGKD------------LLQEEDFYILDQGGFKIYVWQGRMSSLQ 120
Query: 305 VKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR-----TGGSVRGI 359
++ A +++ KGYP++ +V V++GAES+ FKQ F W R GG + I
Sbjct: 121 ERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSI 180
Query: 360 ISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQG 419
++D G T K A A+ M D G G + V I D + G
Sbjct: 181 HVKLDVG-----------KLHTQPKLA-AQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHG 228
Query: 420 TSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTS 479
L Y++ Y YQ +++YLW G +A+ D+ EA +L+ G +
Sbjct: 229 Q--LCAGNCYLVLYTYQRLGRVQ-YILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQ 285
Query: 480 VKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMR 539
V G E HFL+IF+G LV+ + + K TRLF+V+GT++ + R
Sbjct: 286 EHVTMGSEPPHFLAIFQGQLVIF------QERAGHHGKGQSASTTRLFQVQGTDSH-NTR 338
Query: 540 AVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQG 599
++V ++ L D+F+L T S Y+W GK + ++E A + V V+ K+ V +G
Sbjct: 339 TMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMA-RVVVTVISRKNEETVLEG 397
Query: 600 DEPEEFWEALGG---IPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEF 656
EP FWEALGG P K P V V F F
Sbjct: 398 QEPPHFWEALGGRAPYPSNKRLPE---EVPSFQPRLFECSSHMGCLVLAEVGF------F 448
Query: 657 SQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTV 716
SQ+DL + + +LDT +E++ W G +E ++ ++Y++ R+ + +V V
Sbjct: 449 SQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWG--QEYLKTHPAGRS-PATPIVLV 505
Query: 717 KQGAEPRVFKKLFPDWDDGMWSKLSSYEDMKNSTKAANS 755
KQG EP F F WD W+ S++++ + + AA S
Sbjct: 506 KQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAAS 544
Score = 71.3 bits (167), Expect = 1e-11
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 13/192 (6%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSA 74
+E+W I++ P DPK +G+ G+ Y+VL T + + + + W G + T D+ +
Sbjct: 209 VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEAL 268
Query: 75 AIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTNA 134
LD M GG V G E FL+ F+ L I G+ T
Sbjct: 269 NSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQG---QLVIFQERAGHHGKGQSASTT- 324
Query: 135 GAEKRLLKLSGCD--NMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQR---R 189
RL ++ G D N R EV A ASSL + F+L ++ +G QR R
Sbjct: 325 ----RLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMAR 380
Query: 190 KIISVANKLRDE 201
+++V ++ +E
Sbjct: 381 VVVTVISRKNEE 392
>M94345-1|AAA59570.1| 348|Homo sapiens macrophage capping protein
protein.
Length = 348
Score = 180 bits (438), Expect = 2e-44
Identities = 108/339 (31%), Positives = 175/339 (51%), Gaps = 16/339 (4%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G+ +W +E +PVP + G F++GDSY+VL E S H W+G ++++D++G+
Sbjct: 20 GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVS---HLHLWIGQQSSRDEQGA 76
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
A+ + L+ +LG R V HREVQG+ES LF+SYF ++Y EGG ES F++ T
Sbjct: 77 CAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFP-----RGLKYQEGGVESAFHKTSTG 131
Query: 134 A-GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKII 192
A A K+L ++ G N+R E A S CFIL+ +IF + +R K
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKAR 191
Query: 193 SVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISA 252
+A +RD E G+A +EI+ + E+ + LG + + + + +++ A
Sbjct: 192 DLALAIRDSERQGKAQVEIV---TDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQA 248
Query: 253 VYLYKVLDGDEQ---ELVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRK 308
LYKV D Q V+ + P+ + L SD ++LD G G +YIW G + ++
Sbjct: 249 AALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQA 308
Query: 309 YHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
++A ++ Y V + +G ES FKQ+F +W
Sbjct: 309 ALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDW 347
Score = 84.2 bits (199), Expect = 2e-15
Identities = 76/325 (23%), Positives = 137/325 (42%), Gaps = 22/325 (6%)
Query: 417 QQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGN 476
Q+ V + + Y++ + E+ ++LWIG ++S D++ A +L L L
Sbjct: 36 QENQGVFFSGDSYLVLHN----GPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGER 91
Query: 477 VTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGV 536
+ QG ES F+S F L G + + + +L++V+G +
Sbjct: 92 PVQHREVQGNESDLFMSYFPRGLKYQEGGVESAF--HKTSTGAPAAIKKLYQVKGKK--- 146
Query: 537 DMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE----QEAALKFVENVVKDK- 591
++RA + A + D F+L+ G ++ W G S+ E ++ AL ++ + K
Sbjct: 147 NIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKA 206
Query: 592 DVTVVEQGDEPEEFWEALGGIPEEKE-EPSA-WXXXXXXXXXXXXXXXXXSVGVAGRVKF 649
V +V G+EP E + LG P KE P + G K
Sbjct: 207 QVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKV 266
Query: 650 EDLDTEFSQQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRT 707
D + F+ + L D ++LD G ++Y W+G E+ + + +V + +I +
Sbjct: 267 AD-SSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFI---SRMQY 322
Query: 708 VDSAVVVTVKQGAEPRVFKKLFPDW 732
+ V + QG E +FK+ F DW
Sbjct: 323 APNTQVEILPQGRESPIFKQFFKDW 347
>BC014549-1|AAH14549.1| 348|Homo sapiens capping protein (actin
filament), gelsolin-like protein.
Length = 348
Score = 180 bits (438), Expect = 2e-44
Identities = 108/339 (31%), Positives = 175/339 (51%), Gaps = 16/339 (4%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G+ +W +E +PVP + G F++GDSY+VL E S H W+G ++++D++G+
Sbjct: 20 GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVS---HLHLWIGQQSSRDEQGA 76
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
A+ + L+ +LG R V HREVQG+ES LF+SYF ++Y EGG ES F++ T
Sbjct: 77 CAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFP-----RGLKYQEGGVESAFHKTSTG 131
Query: 134 A-GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKII 192
A A K+L ++ G N+R E A S CFIL+ +IF + +R K
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKAR 191
Query: 193 SVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISA 252
+A +RD E G+A +EI+ + E+ + LG + + + + +++ A
Sbjct: 192 DLALAIRDSERQGKAQVEIV---TDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQA 248
Query: 253 VYLYKVLDGDEQ---ELVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRK 308
LYKV D Q V+ + P+ + L SD ++LD G G +YIW G + ++
Sbjct: 249 AALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQA 308
Query: 309 YHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
++A ++ Y V + +G ES FKQ+F +W
Sbjct: 309 ALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDW 347
Score = 84.2 bits (199), Expect = 2e-15
Identities = 76/325 (23%), Positives = 137/325 (42%), Gaps = 22/325 (6%)
Query: 417 QQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGN 476
Q+ V + + Y++ + E+ ++LWIG ++S D++ A +L L L
Sbjct: 36 QENQGVFFSGDSYLVLHN----GPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGER 91
Query: 477 VTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGV 536
+ QG ES F+S F L G + + + +L++V+G +
Sbjct: 92 PVQHREVQGNESDLFMSYFPRGLKYQEGGVESAF--HKTSTGAPAAIKKLYQVKGKK--- 146
Query: 537 DMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE----QEAALKFVENVVKDK- 591
++RA + A + D F+L+ G ++ W G S+ E ++ AL ++ + K
Sbjct: 147 NIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKA 206
Query: 592 DVTVVEQGDEPEEFWEALGGIPEEKE-EPSA-WXXXXXXXXXXXXXXXXXSVGVAGRVKF 649
V +V G+EP E + LG P KE P + G K
Sbjct: 207 QVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKV 266
Query: 650 EDLDTEFSQQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRT 707
D + F+ + L D ++LD G ++Y W+G E+ + + +V + +I +
Sbjct: 267 AD-SSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFI---SRMQY 322
Query: 708 VDSAVVVTVKQGAEPRVFKKLFPDW 732
+ V + QG E +FK+ F DW
Sbjct: 323 APNTQVEILPQGRESPIFKQFFKDW 347
>BC000728-1|AAH00728.1| 348|Homo sapiens capping protein (actin
filament), gelsolin-like protein.
Length = 348
Score = 180 bits (438), Expect = 2e-44
Identities = 108/339 (31%), Positives = 175/339 (51%), Gaps = 16/339 (4%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G+ +W +E +PVP + G F++GDSY+VL E S H W+G ++++D++G+
Sbjct: 20 GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVS---HLHLWIGQQSSRDEQGA 76
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
A+ + L+ +LG R V HREVQG+ES LF+SYF ++Y EGG ES F++ T
Sbjct: 77 CAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFP-----RGLKYQEGGVESAFHKTSTG 131
Query: 134 A-GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKII 192
A A K+L ++ G N+R E A S CFIL+ +IF + +R K
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKAR 191
Query: 193 SVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISA 252
+A +RD E G+A +EI+ + E+ + LG + + + + +++ A
Sbjct: 192 DLALAIRDSERQGKAQVEIV---TDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQA 248
Query: 253 VYLYKVLDGDEQ---ELVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRK 308
LYKV D Q V+ + P+ + L SD ++LD G G +YIW G + ++
Sbjct: 249 AALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQA 308
Query: 309 YHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
++A ++ Y V + +G ES FKQ+F +W
Sbjct: 309 ALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDW 347
Score = 84.2 bits (199), Expect = 2e-15
Identities = 76/325 (23%), Positives = 137/325 (42%), Gaps = 22/325 (6%)
Query: 417 QQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGN 476
Q+ V + + Y++ + E+ ++LWIG ++S D++ A +L L L
Sbjct: 36 QENQGVFFSGDSYLVLHN----GPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGER 91
Query: 477 VTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGV 536
+ QG ES F+S F L G + + + +L++V+G +
Sbjct: 92 PVQHREVQGNESDLFMSYFPRGLKYQEGGVESAF--HKTSTGAPAAIKKLYQVKGKK--- 146
Query: 537 DMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE----QEAALKFVENVVKDK- 591
++RA + A + D F+L+ G ++ W G S+ E ++ AL ++ + K
Sbjct: 147 NIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKA 206
Query: 592 DVTVVEQGDEPEEFWEALGGIPEEKE-EPSA-WXXXXXXXXXXXXXXXXXSVGVAGRVKF 649
V +V G+EP E + LG P KE P + G K
Sbjct: 207 QVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKV 266
Query: 650 EDLDTEFSQQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRT 707
D + F+ + L D ++LD G ++Y W+G E+ + + +V + +I +
Sbjct: 267 AD-SSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFI---SRMQY 322
Query: 708 VDSAVVVTVKQGAEPRVFKKLFPDW 732
+ V + QG E +FK+ F DW
Sbjct: 323 APNTQVEILPQGRESPIFKQFFKDW 347
>AC062037-3|AAY24128.1| 348|Homo sapiens unknown protein.
Length = 348
Score = 180 bits (437), Expect = 2e-44
Identities = 108/339 (31%), Positives = 175/339 (51%), Gaps = 16/339 (4%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G+ +W +E +PVP + G F++GDSY+VL E S H W+G ++++D++G+
Sbjct: 20 GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVS---HLHLWIGQQSSRDEQGA 76
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
A+ + L+ +LG R V HREVQG+ES LF+SYF ++Y EGG ES F++ T
Sbjct: 77 CAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFP-----RGLKYQEGGVESAFHKTSTG 131
Query: 134 A-GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKII 192
A A K+L ++ G N+R E A S CFIL+ +IF + +R K
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKAR 191
Query: 193 SVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISA 252
+A +RD E G+A +EI+ + E+ + LG + + + + +++ A
Sbjct: 192 DLALAIRDSERQGKAQVEIV---TDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQA 248
Query: 253 VYLYKVLDGDEQ---ELVSMNKPYKQKHLASDAMYILDTGDTG-VYIWLGSDLDADVKRK 308
LYKV D Q V+ + P+ + L SD ++LD G G +YIW G + ++
Sbjct: 249 AALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQA 308
Query: 309 YHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
++A ++ Y V + +G ES FKQ+F +W
Sbjct: 309 ALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347
Score = 83.8 bits (198), Expect = 2e-15
Identities = 76/325 (23%), Positives = 137/325 (42%), Gaps = 22/325 (6%)
Query: 417 QQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGN 476
Q+ V + + Y++ + E+ ++LWIG ++S D++ A +L L L
Sbjct: 36 QENQGVFFSGDSYLVLHN----GPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGER 91
Query: 477 VTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGV 536
+ QG ES F+S F L G + + + +L++V+G +
Sbjct: 92 PVQHREVQGNESDLFMSYFPRGLKYQEGGVESAF--HKTSTGAPAAIKKLYQVKGKK--- 146
Query: 537 DMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE----QEAALKFVENVVKDK- 591
++RA + A + D F+L+ G ++ W G S+ E ++ AL ++ + K
Sbjct: 147 NIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKA 206
Query: 592 DVTVVEQGDEPEEFWEALGGIPEEKE-EPSA-WXXXXXXXXXXXXXXXXXSVGVAGRVKF 649
V +V G+EP E + LG P KE P + G K
Sbjct: 207 QVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKV 266
Query: 650 EDLDTEFSQQDLSEDGVYILDTG--EELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRT 707
D + F+ + L D ++LD G ++Y W+G E+ + + +V + +I +
Sbjct: 267 AD-SSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFI---SRMQY 322
Query: 708 VDSAVVVTVKQGAEPRVFKKLFPDW 732
+ V + QG E +FK+ F DW
Sbjct: 323 APNTQVEILPQGHESPIFKQFFKDW 347
>AL513122-5|CAI14415.1| 260|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 260
Score = 177 bits (431), Expect = 1e-43
Identities = 95/262 (36%), Positives = 147/262 (56%), Gaps = 10/262 (3%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 3 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 62
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 63 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 117
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 118 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 177
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSD 239
+ +R K V+ +RD E +GRA + + +E + E + LG ++
Sbjct: 178 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE---AMLQVLGPKPALPAGTE 234
Query: 240 DTSESYTRSDISAVYLYKVLDG 261
DT++ ++ LYKV +G
Sbjct: 235 DTAKE-DAANRKLAKLYKVSNG 255
Score = 74.1 bits (174), Expect = 2e-12
Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 13/196 (6%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
+ + YVI Q N + ++ W+G+E S D+ A + QL++ L G +
Sbjct: 39 FTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREV 98
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
QG ES FL FK L G ++ + + RLF+V+G +RA +V
Sbjct: 99 QGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQ---RLFQVKGRRV---VRATEV 152
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKD------VTVVE 597
+ D F+L+ G+ ++ W G +S+ E+ A + V ++D + V V E
Sbjct: 153 PVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQ-VSKGIRDNERSGRARVHVSE 211
Query: 598 QGDEPEEFWEALGGIP 613
+G EPE + LG P
Sbjct: 212 EGTEPEAMLQVLGPKP 227
>AK075198-1|BAC11465.1| 396|Homo sapiens protein ( Homo sapiens
cDNA FLJ90717 fis, clone PLACE1008657, highly similar to
Bovine mRNA for adseverin. ).
Length = 396
Score = 176 bits (428), Expect = 3e-43
Identities = 124/421 (29%), Positives = 195/421 (46%), Gaps = 32/421 (7%)
Query: 322 YPSWVHVTRVSEGAESSTFKQYFHNW-DTVRTGGSVRGIISEIDSGYFSGDAEESAAAAR 380
Y + + EG E+ FKQ+F +W D ++ G + ++E + + S +
Sbjct: 3 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHS- 61
Query: 381 TIGKSATARGYMPDQGEGSLTVTRISGDQEDVTDRFQQGTSVLYQSEVYVITYKYQNENE 440
A+ M D G G + + R+ + D+ G Y + Y+I Y Y
Sbjct: 62 --SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGE--FYGGDCYIILYTYPRGQ- 116
Query: 441 EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIFKGSLV 500
++Y W G+ A+ D+ L QL+ L G ++V QGKE H LS+FK +
Sbjct: 117 ----IIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPL 172
Query: 501 VLFGSKDDDYQPQNSKKSYE--EDQTRLFRVEGTETGVDMRAVQVAEESNVLEDDDVFVL 558
++ Y+ SKK + TRLF+V + R V+V ++N L +DVFVL
Sbjct: 173 II-------YKNGTSKKGGQAPAPPTRLFQVRRNLASI-TRIVEVDVDANSLNSNDVFVL 224
Query: 559 E--TGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEPEEFWEALGGIPEEK 616
+ SG Y+W GK + QE+E ++V +V+K K + +++G+EPEEFW +LGG + +
Sbjct: 225 KLPQNSG-YIWVGKGAS-QEEEKGAEYVASVLKCKTLR-IQEGEEPEEFWNSLGGKKDYQ 281
Query: 617 EEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYILDTGEELY 676
P GR E++ EF+Q DL+ED V +LD E+++
Sbjct: 282 TSP-----LLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIF 336
Query: 677 FWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWDDGM 736
W G D E K + K Y+E D R + +V+ +KQG EP F F WD
Sbjct: 337 IWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI-IKQGHEPPTFTGWFLGWDSSK 395
Query: 737 W 737
W
Sbjct: 396 W 396
Score = 99 bits (238), Expect = 3e-20
Identities = 89/338 (26%), Positives = 153/338 (45%), Gaps = 26/338 (7%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGSA 74
+EIW +EN + D YG+FY GD YI+L T + + W G+ T+D+ ++
Sbjct: 79 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQII----YTWQGANATRDELTTS 134
Query: 75 AIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTNA 134
A T+ LD LGG+AV R QG E LS FK + I Y G ++ G
Sbjct: 135 AFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPL---IIYKNGTSKKGGQAPAPPT 191
Query: 135 GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILE-NEHDIFVLMPEGAKATQRRKIIS 193
+ L+ RI EV +A+SL N F+L+ ++ ++ + +GA + +
Sbjct: 192 RLFQVRRNLASIT--RIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 249
Query: 194 VANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDTSESYTRSDISAV 253
VA+ L+ + + E +EF + ++T S ++ D Y S+ +
Sbjct: 250 VASVLKCKTLRIQEGEEP-EEFWNSLGGKKDYQT--SPLLETQAEDHPPRLYGCSNKTGR 306
Query: 254 YLYKVLDGDEQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
++ + + G+ + Q LA D + +LD + ++IW+G D + K++ + A
Sbjct: 307 FVIEEIPGE----------FTQDDLAEDDVMLLDAWEQ-IFIWIGKDANEVEKKESLKSA 355
Query: 314 GKYLE--DKGYPSWVHVTRVSEGAESSTFKQYFHNWDT 349
YLE G + + +G E TF +F WD+
Sbjct: 356 KMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDS 393
>AL513122-4|CAI14414.1| 228|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 228
Score = 175 bits (425), Expect = 6e-43
Identities = 86/220 (39%), Positives = 130/220 (59%), Gaps = 6/220 (2%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 14 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 73
Query: 60 FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYL 119
+WLG++ +QD+ G+AAI+T+ LDD L GRAV HREVQG ES+ FL YFK ++Y
Sbjct: 74 YWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKS-----GLKYK 128
Query: 120 EGGNESGFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLM 179
+GG SGF V N +RL ++ G +R EV S CFIL+ ++I
Sbjct: 129 KGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWC 188
Query: 180 PEGAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDE 219
+ +R K V+ +RD E +GRA + + +E + E
Sbjct: 189 GSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPE 228
Score = 69.7 bits (163), Expect = 4e-11
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 13/186 (6%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
+ + YVI Q N + ++ W+G+E S D+ A + QL++ L G +
Sbjct: 50 FTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREV 109
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
QG ES FL FK L G ++ + + RLF+V+G +RA +V
Sbjct: 110 QGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQ---RLFQVKGRRV---VRATEV 163
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKD------VTVVE 597
+ D F+L+ G+ ++ W G +S+ E+ A + V ++D + V V E
Sbjct: 164 PVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQ-VSKGIRDNERSGRARVHVSE 222
Query: 598 QGDEPE 603
+G EPE
Sbjct: 223 EGTEPE 228
>U80184-1|AAC02796.1| 1269|Homo sapiens FLII protein.
Length = 1269
Score = 149 bits (362), Expect = 3e-35
Identities = 121/409 (29%), Positives = 188/409 (45%), Gaps = 26/409 (6%)
Query: 7 EEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKT-TEESSSLTHDAHFWLGSK 65
E+ G G+ IW IENF PV + ++GKFY D YIVLKT ++S SL + ++W+G +
Sbjct: 493 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 552
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
T DKK +AI + L + LG RE G ES FL F I Y+EGG S
Sbjct: 553 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDN-----DISYIEGGTAS 607
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
GF V+ + R+ ++ G N+++E V + +SL F+L+ DI+V A
Sbjct: 608 GFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATL 666
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGS--GSMDELVSDD--- 240
+ K A K+ E G+A I ++ + +++ F+E LG + + V +D
Sbjct: 667 SSTTKARLFAEKINKNERKGKAEITLLVQ---GQELPEFWEALGGEPSEIKKHVPEDFWP 723
Query: 241 TSESYTRSDISAVYL------YKV-LDGDEQELVSMNKPYK--QKHLASDAMYILDTGDT 291
+ + YL YK+ ++ ++ V + + Q L + +YILD +
Sbjct: 724 PQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCW-S 782
Query: 292 GVYIWLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR 351
V+IWLG V+ ++ + P V+R EG E+ FK F NWD V
Sbjct: 783 DVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVL 842
Query: 352 TGGSVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSL 400
T R + + S SG + A + TA ++P Q SL
Sbjct: 843 TVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTAL-FLPRQPPMSL 890
Score = 99.5 bits (237), Expect = 4e-20
Identities = 86/328 (26%), Positives = 136/328 (41%), Gaps = 27/328 (8%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y+++ Y++ + +++ W +Y WIG EA+ D K + L L +V+
Sbjct: 523 YEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREE 582
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
G ES+ FL +F + + G + TR++RV G + +++ V
Sbjct: 583 MGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYV----TRMYRVYGKK---NIKLEPV 635
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ L+ VF+L+ G +YVW G + A F E + K++ ++T++ Q
Sbjct: 636 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ 695
Query: 599 GDEPEEFWEALGGIPEE--KEEP-SAW--------XXXXXXXXXXXXXXXXXSVGVAGRV 647
G E EFWEALGG P E K P W SV R
Sbjct: 696 GQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRP 755
Query: 648 KFEDLD-TEFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDR 706
K E + Q L VYILD +++ W G V+++ +K E G+
Sbjct: 756 KVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAA---ALKLGQELCGMLH 812
Query: 707 TVDSAVVVTVKQGAEPRVFKKLFPDWDD 734
A V +G E +VFK F +WDD
Sbjct: 813 RPRHATVSRSLEGTEAQVFKAKFKNWDD 840
Score = 80.2 bits (189), Expect = 2e-14
Identities = 75/309 (24%), Positives = 130/309 (42%), Gaps = 32/309 (10%)
Query: 436 QNENEED-AWVVYLWIGSEASDDDKEAGQMLLSQLEEDL-EGNVTSVKVPQGKESKHFLS 493
+ + EED +VY W G EAS+ L + E L G + V++ Q +E+ FLS
Sbjct: 973 EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLS 1032
Query: 494 IFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLEDD 553
FK ++ G + K Q L+++ + + R +Q+ +S++L +
Sbjct: 1033 HFKRKFIIHRGKR---------KAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSE 1083
Query: 554 DVFVL------ETGSG-VYVWNGKDSDPQEQEAALKFVENVVKDKDVT--VVEQGDEPEE 604
F+L E G VY W G+ SDP E + A + + N + D + V+ +G+EPE
Sbjct: 1084 FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLA-EDILNTMFDTSYSKQVINEGEEPEN 1142
Query: 605 -FWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSE 663
FW +G ++P G + ++F Q DL++
Sbjct: 1143 FFWVGIGA-----QKP-----YDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLAD 1192
Query: 664 DGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPR 723
D + +LD G+E+Y W G ++ + + YI+ + V++G E
Sbjct: 1193 DDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQH 1252
Query: 724 VFKKLFPDW 732
F + F W
Sbjct: 1253 AFTRCFHAW 1261
Score = 45.6 bits (103), Expect = 7e-04
Identities = 38/164 (23%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
S L SE + K E+E++ +VY W+G + D+ + + +L+ + + + +
Sbjct: 1077 SSLLNSE-FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTM---FDTSYSKQ 1132
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET--GVDM 538
+ +G+E ++F + G+ +P + Y + TRLFR + V
Sbjct: 1133 VINEGEEPENFFWVGIGA-----------QKPYDDDAEYMK-HTRLFRCSNEKGYFAVTE 1180
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALK 582
+ ++ L DDD+ +L+ G VY+W G + E + +LK
Sbjct: 1181 KCSDFCQDD--LADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLK 1222
>U01184-1|AAC03568.1| 1268|Homo sapiens flightless-I homolog
protein.
Length = 1268
Score = 149 bits (362), Expect = 3e-35
Identities = 121/409 (29%), Positives = 188/409 (45%), Gaps = 26/409 (6%)
Query: 7 EEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKT-TEESSSLTHDAHFWLGSK 65
E+ G G+ IW IENF PV + ++GKFY D YIVLKT ++S SL + ++W+G +
Sbjct: 492 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 551
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
T DKK +AI + L + LG RE G ES FL F I Y+EGG S
Sbjct: 552 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDN-----DISYIEGGTAS 606
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
GF V+ + R+ ++ G N+++E V + +SL F+L+ DI+V A
Sbjct: 607 GFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATL 665
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGS--GSMDELVSDD--- 240
+ K A K+ E G+A I ++ + +++ F+E LG + + V +D
Sbjct: 666 SSTTKARLFAEKINKNERKGKAEITLLVQ---GQELPEFWEALGGEPSEIKKHVPEDFWP 722
Query: 241 TSESYTRSDISAVYL------YKV-LDGDEQELVSMNKPYK--QKHLASDAMYILDTGDT 291
+ + YL YK+ ++ ++ V + + Q L + +YILD +
Sbjct: 723 PQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCW-S 781
Query: 292 GVYIWLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR 351
V+IWLG V+ ++ + P V+R EG E+ FK F NWD V
Sbjct: 782 DVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVL 841
Query: 352 TGGSVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSL 400
T R + + S SG + A + TA ++P Q SL
Sbjct: 842 TVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTAL-FLPRQPPMSL 889
Score = 99.5 bits (237), Expect = 4e-20
Identities = 86/328 (26%), Positives = 136/328 (41%), Gaps = 27/328 (8%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y+++ Y++ + +++ W +Y WIG EA+ D K + L L +V+
Sbjct: 522 YEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREE 581
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
G ES+ FL +F + + G + TR++RV G + +++ V
Sbjct: 582 MGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYV----TRMYRVYGKK---NIKLEPV 634
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ L+ VF+L+ G +YVW G + A F E + K++ ++T++ Q
Sbjct: 635 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ 694
Query: 599 GDEPEEFWEALGGIPEE--KEEP-SAW--------XXXXXXXXXXXXXXXXXSVGVAGRV 647
G E EFWEALGG P E K P W SV R
Sbjct: 695 GQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRP 754
Query: 648 KFEDLD-TEFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDR 706
K E + Q L VYILD +++ W G V+++ +K E G+
Sbjct: 755 KVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAA---ALKLGQELCGMLH 811
Query: 707 TVDSAVVVTVKQGAEPRVFKKLFPDWDD 734
A V +G E +VFK F +WDD
Sbjct: 812 RPRHATVSRSLEGTEAQVFKAKFKNWDD 839
Score = 80.2 bits (189), Expect = 2e-14
Identities = 75/309 (24%), Positives = 130/309 (42%), Gaps = 32/309 (10%)
Query: 436 QNENEED-AWVVYLWIGSEASDDDKEAGQMLLSQLEEDL-EGNVTSVKVPQGKESKHFLS 493
+ + EED +VY W G EAS+ L + E L G + V++ Q +E+ FLS
Sbjct: 972 EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLS 1031
Query: 494 IFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLEDD 553
FK ++ G + K Q L+++ + + R +Q+ +S++L +
Sbjct: 1032 HFKRKFIIHRGKR---------KAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSE 1082
Query: 554 DVFVL------ETGSG-VYVWNGKDSDPQEQEAALKFVENVVKDKDVT--VVEQGDEPEE 604
F+L E G VY W G+ SDP E + A + + N + D + V+ +G+EPE
Sbjct: 1083 FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLA-EDILNTMFDTSYSKQVINEGEEPEN 1141
Query: 605 -FWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSE 663
FW +G ++P G + ++F Q DL++
Sbjct: 1142 FFWVGIGA-----QKP-----YDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLAD 1191
Query: 664 DGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPR 723
D + +LD G+E+Y W G ++ + + YI+ + V++G E
Sbjct: 1192 DDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQH 1251
Query: 724 VFKKLFPDW 732
F + F W
Sbjct: 1252 AFTRCFHAW 1260
Score = 45.6 bits (103), Expect = 7e-04
Identities = 38/164 (23%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
S L SE + K E+E++ +VY W+G + D+ + + +L+ + + + +
Sbjct: 1076 SSLLNSE-FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTM---FDTSYSKQ 1131
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET--GVDM 538
+ +G+E ++F + G+ +P + Y + TRLFR + V
Sbjct: 1132 VINEGEEPENFFWVGIGA-----------QKPYDDDAEYMK-HTRLFRCSNEKGYFAVTE 1179
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALK 582
+ ++ L DDD+ +L+ G VY+W G + E + +LK
Sbjct: 1180 KCSDFCQDD--LADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLK 1221
>BC025300-1|AAH25300.1| 1269|Homo sapiens flightless I homolog
(Drosophila) protein.
Length = 1269
Score = 149 bits (362), Expect = 3e-35
Identities = 121/409 (29%), Positives = 188/409 (45%), Gaps = 26/409 (6%)
Query: 7 EEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKT-TEESSSLTHDAHFWLGSK 65
E+ G G+ IW IENF PV + ++GKFY D YIVLKT ++S SL + ++W+G +
Sbjct: 493 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 552
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
T DKK +AI + L + LG RE G ES FL F I Y+EGG S
Sbjct: 553 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDN-----DISYIEGGTAS 607
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
GF V+ + R+ ++ G N+++E V + +SL F+L+ DI+V A
Sbjct: 608 GFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATL 666
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGS--GSMDELVSDD--- 240
+ K A K+ E G+A I ++ + +++ F+E LG + + V +D
Sbjct: 667 SSTTKARLFAEKINKNERKGKAEITLLVQ---GQELPEFWEALGGEPSEIKKHVPEDFWP 723
Query: 241 TSESYTRSDISAVYL------YKV-LDGDEQELVSMNKPYK--QKHLASDAMYILDTGDT 291
+ + YL YK+ ++ ++ V + + Q L + +YILD +
Sbjct: 724 PQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCW-S 782
Query: 292 GVYIWLGSDLDADVKRKYHEIAGKYLEDKGYPSWVHVTRVSEGAESSTFKQYFHNWDTVR 351
V+IWLG V+ ++ + P V+R EG E+ FK F NWD V
Sbjct: 783 DVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVL 842
Query: 352 TGGSVRGIISEIDSGYFSGDAEESAAAARTIGKSATARGYMPDQGEGSL 400
T R + + S SG + A + TA ++P Q SL
Sbjct: 843 TVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTAL-FLPRQPPMSL 890
Score = 99.5 bits (237), Expect = 4e-20
Identities = 86/328 (26%), Positives = 136/328 (41%), Gaps = 27/328 (8%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y+++ Y++ + +++ W +Y WIG EA+ D K + L L +V+
Sbjct: 523 YEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREE 582
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
G ES+ FL +F + + G + TR++RV G + +++ V
Sbjct: 583 MGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYV----TRMYRVYGKK---NIKLEPV 635
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ L+ VF+L+ G +YVW G + A F E + K++ ++T++ Q
Sbjct: 636 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ 695
Query: 599 GDEPEEFWEALGGIPEE--KEEP-SAW--------XXXXXXXXXXXXXXXXXSVGVAGRV 647
G E EFWEALGG P E K P W SV R
Sbjct: 696 GQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRP 755
Query: 648 KFEDLD-TEFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDR 706
K E + Q L VYILD +++ W G V+++ +K E G+
Sbjct: 756 KVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAA---ALKLGQELCGMLH 812
Query: 707 TVDSAVVVTVKQGAEPRVFKKLFPDWDD 734
A V +G E +VFK F +WDD
Sbjct: 813 RPRHATVSRSLEGTEAQVFKAKFKNWDD 840
Score = 80.2 bits (189), Expect = 2e-14
Identities = 75/309 (24%), Positives = 130/309 (42%), Gaps = 32/309 (10%)
Query: 436 QNENEED-AWVVYLWIGSEASDDDKEAGQMLLSQLEEDL-EGNVTSVKVPQGKESKHFLS 493
+ + EED +VY W G EAS+ L + E L G + V++ Q +E+ FLS
Sbjct: 973 EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLS 1032
Query: 494 IFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLEDD 553
FK ++ G + K Q L+++ + + R +Q+ +S++L +
Sbjct: 1033 HFKRKFIIHRGKR---------KAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSE 1083
Query: 554 DVFVL------ETGSG-VYVWNGKDSDPQEQEAALKFVENVVKDKDVT--VVEQGDEPEE 604
F+L E G VY W G+ SDP E + A + + N + D + V+ +G+EPE
Sbjct: 1084 FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLA-EDILNTMFDTSYSKQVINEGEEPEN 1142
Query: 605 -FWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSE 663
FW +G ++P G + ++F Q DL++
Sbjct: 1143 FFWVGIGA-----QKP-----YDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLAD 1192
Query: 664 DGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEPR 723
D + +LD G+E+Y W G ++ + + YI+ + V++G E
Sbjct: 1193 DDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQH 1252
Query: 724 VFKKLFPDW 732
F + F W
Sbjct: 1253 AFTRCFHAW 1261
Score = 45.6 bits (103), Expect = 7e-04
Identities = 38/164 (23%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
S L SE + K E+E++ +VY W+G + D+ + + +L+ + + + +
Sbjct: 1077 SSLLNSE-FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTM---FDTSYSKQ 1132
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET--GVDM 538
+ +G+E ++F + G+ +P + Y + TRLFR + V
Sbjct: 1133 VINEGEEPENFFWVGIGA-----------QKPYDDDAEYMK-HTRLFRCSNEKGYFAVTE 1180
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALK 582
+ ++ L DDD+ +L+ G VY+W G + E + +LK
Sbjct: 1181 KCSDFCQDD--LADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLK 1222
>BC017491-1|AAH17491.1| 285|Homo sapiens Similar to gelsolin
(amyloidosis, Finnish type) protein.
Length = 285
Score = 145 bits (352), Expect = 4e-34
Identities = 93/285 (32%), Positives = 138/285 (48%), Gaps = 13/285 (4%)
Query: 454 ASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQ 513
++ D+ A +L +QL+E+L G +V QGKE H +S+F G ++++ Q
Sbjct: 1 STQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQ 60
Query: 514 NSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSD 573
+ S TRLF+V G RAV+V ++ L +D FVL+T S Y+W G +
Sbjct: 61 TAPAS-----TRLFQVRANSAGA-TRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGAS 114
Query: 574 PQEQEAALKFVENVVKDKDVTVVEQGDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXX 633
E+ A + + V++ + V V E G EP+ FWEALGG + P
Sbjct: 115 EAEKTGAQELL-RVLRAQPVQVAE-GSEPDGFWEALGGKAAYRTSP----RLKDKKMDAH 168
Query: 634 XXXXXXSVGVAGRVKFEDLDTEFSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQE 693
GR E++ E Q+DL+ D V +LDT ++++ W G D E K+
Sbjct: 169 PPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALT 228
Query: 694 VIKKYIEDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWDDGMWS 738
K+YIE D +R + + V VKQG EP F F WDD WS
Sbjct: 229 SAKRYIETDPANRDRRTPITV-VKQGFEPPSFVGWFLGWDDDYWS 272
Score = 66.9 bits (156), Expect = 2e-10
Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 30/290 (10%)
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYF--KPVSIHLAIRYLEGGN 123
+TQD+ ++AI T LD+ LGG V R VQG E + +S F KP+ I+ EGG
Sbjct: 1 STQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGG- 59
Query: 124 ESGFNEVQTNAGAEKRL--LKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPE 181
QT A A RL ++ + R EV +A +L N F+L+ ++ +
Sbjct: 60 -------QT-APASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGT 111
Query: 182 GAKATQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVSDDT 241
GA ++ + LR + +++ + D F+E LG G S
Sbjct: 112 GASEAEKTGAQELLRVLRAQ------PVQVAEGSEPDG----FWEALG-GKAAYRTSPRL 160
Query: 242 SESYTRSDISAVYLYKVLDGDEQELV-SMNKPYKQKHLASDAMYILDTGDTGVYIWLGSD 300
+ + D L+ + + ++ + Q+ LA+D + +LDT D V++W+G D
Sbjct: 161 KDK--KMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQ-VFVWVGKD 217
Query: 301 LDADVKRKYHEIAGKYLE--DKGYPSWVHVTRVSEGAESSTFKQYFHNWD 348
+ K + A +Y+E +T V +G E +F +F WD
Sbjct: 218 SQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWD 267
Score = 56.4 bits (130), Expect = 4e-07
Identities = 54/181 (29%), Positives = 77/181 (42%), Gaps = 27/181 (14%)
Query: 439 NEEDAWVV------YLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFL 492
N DA+V+ YLW+G+ AS+ +K Q LL L V+V +G E F
Sbjct: 92 NSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL------RAQPVQVAEGSEPDGFW 145
Query: 493 SIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLED 552
L G P+ K + RLF + V L
Sbjct: 146 E-------ALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLAT 198
Query: 553 DDVFVLETGSGVYVWNGKDSDPQEQEAAL----KFVENVVKDKD----VTVVEQGDEPEE 604
DDV +L+T V+VW GKDS +E+ AL +++E ++D +TVV+QG EP
Sbjct: 199 DDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPS 258
Query: 605 F 605
F
Sbjct: 259 F 259
>AB208864-1|BAD92101.1| 1101|Homo sapiens flightless I homolog
variant protein.
Length = 1101
Score = 130 bits (313), Expect = 2e-29
Identities = 84/245 (34%), Positives = 127/245 (51%), Gaps = 13/245 (5%)
Query: 7 EEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKT-TEESSSLTHDAHFWLGSK 65
E+ G G+ IW IENF PV + ++GKFY D YIVLKT ++S SL + ++W+G +
Sbjct: 480 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 539
Query: 66 TTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNES 125
T DKK +AI + L + LG RE G ES FL F I Y+EGG S
Sbjct: 540 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDN-----DISYIEGGTAS 594
Query: 126 GFNEVQTNAGAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKA 185
GF V+ + R+ ++ G N+++E V + +SL F+L+ DI+V A
Sbjct: 595 GFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATL 653
Query: 186 TQRRKIISVANKLRDEEHNGRATIEIIDEFSSDEDVNLFFETLGSGSMDELVS-DDT-SE 243
+ K A K+ E G+A I ++ + +++ F+E LG G E+ + DD +
Sbjct: 654 SSTTKARLFAEKINKNERKGKAEITLLVQ---GQELPEFWEALG-GEPSEIKNWDDVLTV 709
Query: 244 SYTRS 248
YTR+
Sbjct: 710 DYTRN 714
Score = 93.1 bits (221), Expect = 3e-18
Identities = 62/244 (25%), Positives = 108/244 (44%), Gaps = 15/244 (6%)
Query: 424 YQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVP 483
Y+++ Y++ + +++ W +Y WIG EA+ D K + L L +V+
Sbjct: 510 YEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREE 569
Query: 484 QGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQV 543
G ES+ FL +F + + G + TR++RV G + +++ V
Sbjct: 570 MGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYV----TRMYRVYGKK---NIKLEPV 622
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDK-----DVTVVEQ 598
+ L+ VF+L+ G +YVW G + A F E + K++ ++T++ Q
Sbjct: 623 PLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQ 682
Query: 599 GDEPEEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQ 658
G E EFWEALGG P E + W S G++G+VK + + +
Sbjct: 683 GQELPEFWEALGGEPSEIKN---WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMK 739
Query: 659 QDLS 662
DL+
Sbjct: 740 ADLT 743
Score = 75.8 bits (178), Expect = 5e-13
Identities = 67/262 (25%), Positives = 115/262 (43%), Gaps = 32/262 (12%)
Query: 436 QNENEED-AWVVYLWIGSEASDDDKEAGQMLLSQLEEDL-EGNVTSVKVPQGKESKHFLS 493
+ + EED +VY W G EAS+ L + E L G + V++ Q +E+ FLS
Sbjct: 838 EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLS 897
Query: 494 IFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLEDD 553
FK ++ G + K Q L+++ + + R +Q+ +S++L +
Sbjct: 898 HFKRKFIIHRGKR---------KAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSE 948
Query: 554 DVFVL------ETGSG-VYVWNGKDSDPQEQEAALKFVENVVKDKDVT--VVEQGDEPEE 604
F+L E G VY W G+ SDP E + A + + N + D + V+ +G+EPE
Sbjct: 949 FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLA-EDILNTMFDTSYSKQVINEGEEPEN 1007
Query: 605 -FWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLSE 663
FW +G ++P G + ++F Q DL++
Sbjct: 1008 FFWVGIGA-----QKP-----YDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLAD 1057
Query: 664 DGVYILDTGEELYFWQGADVTE 685
D + +LD G+E+Y W G ++
Sbjct: 1058 DDIMLLDNGQEVYMWVGTQTSQ 1079
Score = 45.6 bits (103), Expect = 7e-04
Identities = 38/164 (23%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 421 SVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSV 480
S L SE + K E+E++ +VY W+G + D+ + + +L+ + + + +
Sbjct: 942 SSLLNSE-FCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTM---FDTSYSKQ 997
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTET--GVDM 538
+ +G+E ++F + G+ +P + Y + TRLFR + V
Sbjct: 998 VINEGEEPENFFWVGIGA-----------QKPYDDDAEYMK-HTRLFRCSNEKGYFAVTE 1045
Query: 539 RAVQVAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALK 582
+ ++ L DDD+ +L+ G VY+W G + E + +LK
Sbjct: 1046 KCSDFCQDD--LADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLK 1087
>U12026-1|AAA92670.1| 172|Homo sapiens Cap-G protein.
Length = 172
Score = 121 bits (291), Expect = 1e-26
Identities = 62/158 (39%), Positives = 93/158 (58%), Gaps = 9/158 (5%)
Query: 14 GIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLGSKTTQDKKGS 73
G+ +W +E +PVP + G F++GDSY+VL E S H W+G ++++D++G+
Sbjct: 20 GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVS---HLHLWIGQQSSRDEQGA 76
Query: 74 AAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFKPVSIHLAIRYLEGGNESGFNEVQTN 133
A+ + L+ +LG R V HREVQG+ES LF+SYF ++Y EGG ES F++ T
Sbjct: 77 CAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFP-----RGLKYQEGGVESAFHKTSTG 131
Query: 134 A-GAEKRLLKLSGCDNMRIEEVAAEASSLTKNHCFILE 170
A A K+L ++ G N+R E A S CFIL+
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILD 169
Score = 39.5 bits (88), Expect = 0.043
Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 9/145 (6%)
Query: 417 QQGTSVLYQSEVYVITYKYQNENEEDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGN 476
Q+ V + + Y++ + E+ ++LWIG ++S D++ A +L L L
Sbjct: 36 QENQGVFFSGDSYLVLHN----GPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGER 91
Query: 477 VTSVKVPQGKESKHFLSIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGV 536
+ QG ES F+S F L G + + + +L++V+G +
Sbjct: 92 PVQHREVQGNESDLFMSYFPRGLKYQEGGVESAF--HKTSTGAPAAIKKLYQVKGKK--- 146
Query: 537 DMRAVQVAEESNVLEDDDVFVLETG 561
++RA + A + D F+L+ G
Sbjct: 147 NIRATERALNWDSFNTGDCFILDLG 171
>AL513122-9|CAI14417.1| 207|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 207
Score = 104 bits (250), Expect = 1e-21
Identities = 65/196 (33%), Positives = 93/196 (47%), Gaps = 7/196 (3%)
Query: 543 VAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEP 602
V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V V E G EP
Sbjct: 6 VLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLR-VLRAQPVQVAE-GSEP 63
Query: 603 EEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLS 662
+ FWEALGG + P GR E++ E Q+DL+
Sbjct: 64 DGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLA 119
Query: 663 EDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEP 722
D V +LDT ++++ W G D E K+ K+YIE D +R + + V VKQG EP
Sbjct: 120 TDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV-VKQGFEP 178
Query: 723 RVFKKLFPDWDDGMWS 738
F F WDD WS
Sbjct: 179 PSFVGWFLGWDDDYWS 194
Score = 56.4 bits (130), Expect = 4e-07
Identities = 53/181 (29%), Positives = 76/181 (41%), Gaps = 27/181 (14%)
Query: 439 NEEDAWVV------YLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFL 492
N DA+V+ YLW+G+ AS+ +K Q LL L V+V +G E F
Sbjct: 14 NSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQ------PVQVAEGSEPDGFW 67
Query: 493 SIFKGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVAEESNVLED 552
G P+ K + RLF + V L
Sbjct: 68 EALGGKAAYRTS-------PRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLAT 120
Query: 553 DDVFVLETGSGVYVWNGKDSDPQEQEAAL----KFVENVVKDKD----VTVVEQGDEPEE 604
DDV +L+T V+VW GKDS +E+ AL +++E ++D +TVV+QG EP
Sbjct: 121 DDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPS 180
Query: 605 F 605
F
Sbjct: 181 F 181
Score = 41.1 bits (92), Expect = 0.014
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query: 275 QKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIAGKYLE--DKGYPSWVHVTRVS 332
Q+ LA+D + +LDT D V++W+G D + K + A +Y+E +T V
Sbjct: 115 QEDLATDDVMLLDTWDQ-VFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVK 173
Query: 333 EGAESSTFKQYFHNWD 348
+G E +F +F WD
Sbjct: 174 QGFEPPSFVGWFLGWD 189
>AL513122-8|CAI14418.1| 188|Homo sapiens gelsolin (amyloidosis,
Finnish type) protein.
Length = 188
Score = 79.0 bits (186), Expect = 6e-14
Identities = 62/196 (31%), Positives = 86/196 (43%), Gaps = 26/196 (13%)
Query: 543 VAEESNVLEDDDVFVLETGSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEP 602
V ++ L +D FVL+T S Y+W G + E+ A + + V++ + V V E G EP
Sbjct: 6 VLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLR-VLRAQPVQVAE-GSEP 63
Query: 603 EEFWEALGGIPEEKEEPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDLS 662
+ FWEALGG + P GR E++ E Q+DL+
Sbjct: 64 DGFWEALGGKAAYRTSP----RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLA 119
Query: 663 EDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVTVKQGAEP 722
D V +LDT W +V K+YIE D +R + + V VKQG EP
Sbjct: 120 TDDVMLLDT------W-------------DQVAKRYIETDPANRDRRTPITV-VKQGFEP 159
Query: 723 RVFKKLFPDWDDGMWS 738
F F WDD WS
Sbjct: 160 PSFVGWFLGWDDDYWS 175
>AL160060-2|CAH71301.1| 1788|Homo sapiens supervillin protein.
Length = 1788
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1138
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1139 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1197
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1198 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1256
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1257 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1316
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1317 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1376
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1377 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1433
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1434 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1485
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1486 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1545
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1546 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 1605
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 1606 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 1665
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 1666 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 1697
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1328 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1387
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1388 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1444
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1445 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1494
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1495 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1522
>AL160060-1|CAH71300.1| 2214|Homo sapiens supervillin protein.
Length = 2214
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1445 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1504
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1505 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1564
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1565 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1623
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1624 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1682
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1683 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1742
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1743 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1802
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1803 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1859
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1860 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1911
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1912 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1971
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1972 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 2031
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 2032 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 2091
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 2092 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 2123
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1754 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1813
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1814 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1870
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1871 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1920
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1921 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1948
>AL158167-3|CAI15237.1| 2214|Homo sapiens supervillin protein.
Length = 2214
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1445 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1504
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1505 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1564
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1565 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1623
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1624 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1682
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1683 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1742
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1743 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1802
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1803 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1859
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1860 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1911
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1912 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1971
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1972 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 2031
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 2032 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 2091
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 2092 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 2123
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1754 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1813
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1814 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1870
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1871 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1920
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1921 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1948
>AL158167-2|CAI15236.1| 1788|Homo sapiens supervillin protein.
Length = 1788
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1138
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1139 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1197
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1198 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1256
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1257 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1316
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1317 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1376
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1377 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1433
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1434 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1485
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1486 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1545
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1546 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 1605
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 1606 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 1665
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 1666 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 1697
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1328 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1387
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1388 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1444
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1445 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1494
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1495 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1522
>AF109135-1|AAD14682.1| 2214|Homo sapiens archvillin protein.
Length = 2214
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1445 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1504
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1505 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1564
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1565 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1623
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1624 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1682
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1683 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1742
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1743 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1802
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1803 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1859
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1860 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1911
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1912 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1971
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1972 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 2031
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 2032 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 2091
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 2092 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 2123
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1754 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1813
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1814 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1870
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1871 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1920
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1921 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1948
>AF051851-1|AAC64696.1| 1788|Homo sapiens supervillin protein.
Length = 1788
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1138
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1139 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1197
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1198 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1256
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1257 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1316
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1317 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1376
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1377 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1433
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1434 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1485
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1486 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1545
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1546 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 1605
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 1606 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 1665
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 1666 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 1697
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1328 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1387
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1388 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1444
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1445 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1494
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1495 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1522
>AF051850-1|AAC64695.1| 1788|Homo sapiens supervillin protein.
Length = 1788
Score = 72.5 bits (170), Expect = 5e-12
Identities = 143/694 (20%), Positives = 274/694 (39%), Gaps = 115/694 (16%)
Query: 140 LLKLSGCDNMRIEEVAAEASSLTKNHCFILENEHDIFVLMPEGAKATQRRKIISVANKLR 199
LL++ G +++ V AS+L CF+L + H F+ + E A ++ K +A ++
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078
Query: 200 DEEHNG-RAT-IEIIDEFSSDED--VNLFFETLGSGSMDELVSDDTS-ESYTRSDISAVY 254
+ G RAT I+ I+E + F++ LG + + D E Y + I
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1138
Query: 255 LYKVLDGD-EQELVSMNKPYKQKHLASDAMYILDTGDTGVYIWLGSDLDADVKRKYHEIA 313
+Y+++D + K K L + + D G VY+W G ++ ++ ++A
Sbjct: 1139 IYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSE-VYVWHGKEVTLAQRKIAFQLA 1197
Query: 314 GKYL--------------------------EDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
K+L + +G P W R++E E+ FK+ F +W
Sbjct: 1198 -KHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDW 1256
Query: 348 DTVRTG-----GSVRGIISEIDSGYFSGDAEESAAAARTIGKSA-----TARGYMPDQGE 397
++ G + + + + D + +T + RGY +G
Sbjct: 1257 TELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGH 1316
Query: 398 G--SLTVTRISGD-----QEDVTDRFQQGTSVLYQSEVYVITYKY----------QNENE 440
+T +S D + D + +Q ++ + YV+ +K+ + E+
Sbjct: 1317 DRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHS 1376
Query: 441 -----EDAWVVYLWIGSEASDDDKEAGQMLLSQLEEDLEGNVTSVKVPQGKESKHFLSIF 495
++ V + W G ++ +K ++ +L+E+ V+V QGKE FL F
Sbjct: 1377 VRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEE---RGAQVQVLQGKEPPCFLQCF 1433
Query: 496 KGSLVVLFGSKDDDYQPQNSKKSYEEDQTRLFRVEGTETGVDMRAVQVA-EESNVLEDDD 554
+G +VV G ++++ + S + RL+ V G E V+ ++VA S++
Sbjct: 1434 QGGMVVHSGRREEEEENVQS-------EWRLYCVRG-EVPVEGNLLEVACHCSSLRSRTS 1485
Query: 555 VFVLETGSG-VYVWNGKDSDPQEQE----AALKFVE------NVVKDKDVTVVE--QGDE 601
+ VL +Y+W+G + +E AA K E + VT+ E +G E
Sbjct: 1486 MVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 1545
Query: 602 PEEFWEALGGIPEEK-----EEPSAWXXXXXXXXXXXXXXXXXSVGVA--GRVKFEDLDT 654
P FW+ALG + ++P ++ + R
Sbjct: 1546 PLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 1605
Query: 655 EFSQQDL---SEDGVYILDTGEELYFWQG-ADVTERV-----------KSSKQEVIKKYI 699
F Q+DL + ++++D E+Y WQG + ++ + S E + +Y
Sbjct: 1606 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 1665
Query: 700 EDDGLDRTVDSAVVVTVKQGAEPRVFKKLFPDWD 733
+ L + + + + G EP F +FP W+
Sbjct: 1666 KGKNLKKPAPKSYL--IHAGLEPLTFTNMFPSWE 1697
Score = 46.8 bits (106), Expect = 3e-04
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 15 IEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSL------THDAH--------- 59
+++W I F+ + G+F+ GD+Y+V S+++ H
Sbjct: 1328 VDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVY 1387
Query: 60 -FWLGSKTTQDKKGSAAIWTITLDDMLGGRAVHHREVQGHESSLFLSYFK-PVSIHLAIR 117
FW G +T +KG++A+ T+ LD+ G + + +QG E FL F+ + +H R
Sbjct: 1388 FFWQGRHSTVSEKGTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRR 1444
Query: 118 YLEGGNESGFNEVQTNAGAEKRLLKLSGCDNM--RIEEVAAEASSLTKNHCFILENEHDI 175
E + N +E RL + G + + EVA SSL ++ N +
Sbjct: 1445 ----------EEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA 1494
Query: 176 FVLMPEGAKATQRRKII--SVANKLRDE 201
+ + G KA K + + ANK++++
Sbjct: 1495 LIYLWHGCKAQAHTKEVGRTAANKIKEQ 1522
>X07066-1|CAA30102.1| 69|Homo sapiens protein ( Human gene for
gelsolin exon 4. ).
Length = 69
Score = 71.3 bits (167), Expect = 1e-11
Identities = 27/64 (42%), Positives = 44/64 (68%), Gaps = 1/64 (1%)
Query: 1 MENPVFEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTE-ESSSLTHDAH 59
+E+P F +AG + G++IW +E F+ VP YG F+ GD+Y++LKT + + +L +D H
Sbjct: 6 VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLH 65
Query: 60 FWLG 63
+WLG
Sbjct: 66 YWLG 69
>BC075797-1|AAH75797.1| 85|Homo sapiens Unknown (protein for
MGC:87550) protein.
Length = 85
Score = 67.7 bits (158), Expect = 1e-10
Identities = 28/58 (48%), Positives = 36/58 (62%)
Query: 6 FEEAGNQAGIEIWTIENFEPVPFDPKYYGKFYNGDSYIVLKTTEESSSLTHDAHFWLG 63
F AG QAG+++W IE E VP +G FY GD+Y+VL T + S T+ HFWLG
Sbjct: 10 FARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLG 67
>AC073232-1|AAS07450.1| 100|Homo sapiens unknown protein.
Length = 100
Score = 59.3 bits (137), Expect = 5e-08
Identities = 31/76 (40%), Positives = 50/76 (65%), Gaps = 5/76 (6%)
Query: 546 ESNVLEDDDVFVLET--GSGVYVWNGKDSDPQEQEAALKFVENVVKDKDVTVVEQGDEPE 603
++N L +DVFVL+ SG Y+W GK + QE+E ++V +V+K K + + ++G+EPE
Sbjct: 4 DANSLNSNDVFVLKLPQNSG-YIWVGKGAS-QEEEKGAEYVASVLKCKTLRI-QEGEEPE 60
Query: 604 EFWEALGGIPEEKEEP 619
EFW +LGG + + P
Sbjct: 61 EFWNSLGGKKDYQTSP 76
>AB209574-1|BAD92811.1| 326|Homo sapiens villin-like variant
protein.
Length = 326
Score = 52.4 bits (120), Expect = 6e-06
Identities = 30/100 (30%), Positives = 55/100 (55%), Gaps = 3/100 (3%)
Query: 656 FSQQDLSEDGVYILDTGEELYFWQGADVTERVKSSKQEVIKKYIEDDGLDRTVDSAVVVT 715
FSQ+DL + + +LDT +E++ W G +E ++ ++Y++ R+ + +V+
Sbjct: 194 FSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWG--QEYLKTHPAGRSPATPIVL- 250
Query: 716 VKQGAEPRVFKKLFPDWDDGMWSKLSSYEDMKNSTKAANS 755
VKQG EP F F WD W+ S++++ + + AA S
Sbjct: 251 VKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAAS 290
>AK022448-1|BAB14038.1| 126|Homo sapiens protein ( Homo sapiens
cDNA FLJ12386 fis, clone MAMMA1002622, moderately
similar to VILLIN. ).
Length = 126
Score = 37.9 bits (84), Expect = 0.13
Identities = 15/32 (46%), Positives = 22/32 (68%)
Query: 316 YLEDKGYPSWVHVTRVSEGAESSTFKQYFHNW 347
+++ K YPS +V V++GAES+ FKQ F W
Sbjct: 66 FIKMKSYPSSTNVETVNDGAESAMFKQLFQKW 97
>AK024710-1|BAB14971.1| 288|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21057 fis, clone CAS00705. ).
Length = 288
Score = 33.1 bits (72), Expect = 3.7
Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 5/123 (4%)
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE-QEAALKFVENVVKDKDVTVVEQGDEP 602
AE++ L+ D +LETG V + + + S P++ Q+A + E KD ++ + +
Sbjct: 21 AEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKK 80
Query: 603 EEFWEALGGIPEEKE-EPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDL 661
E + + G P EKE S+ S G +G+ K +++ S+
Sbjct: 81 E---DCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSS 137
Query: 662 SED 664
+D
Sbjct: 138 KDD 140
>AK000867-1|BAA91401.1| 511|Homo sapiens protein ( Homo sapiens
cDNA FLJ10005 fis, clone HEMBA1000156. ).
Length = 511
Score = 33.1 bits (72), Expect = 3.7
Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 5/123 (4%)
Query: 544 AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE-QEAALKFVENVVKDKDVTVVEQGDEP 602
AE++ L+ D +LETG V + + + S P++ Q+A + E KD ++ + +
Sbjct: 249 AEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKK 308
Query: 603 EEFWEALGGIPEEKE-EPSAWXXXXXXXXXXXXXXXXXSVGVAGRVKFEDLDTEFSQQDL 661
E + + G P EKE S+ S G +G+ K +++ S+
Sbjct: 309 E---DCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSS 365
Query: 662 SED 664
+D
Sbjct: 366 KDD 368
>D79984-1|BAA11479.2| 1730|Homo sapiens KIAA0162 protein.
Length = 1730
Score = 32.7 bits (71), Expect = 4.9
Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 18/129 (13%)
Query: 508 DDYQPQNSKKSY---EEDQTRLFRVEGTETG-----VDMRAVQVAEESNVLEDDDVFVLE 559
DD Q + K + ++D+ EG+++G V + + + LEDDD ++E
Sbjct: 50 DDQDEQGNLKGFINDDDDEDEGEEDEGSDSGDSEDDVGHKKRKRTSFDDRLEDDDFDLIE 109
Query: 560 TGSGVYVWNGK----------DSDPQEQEAALKFVENVVKDKDVTVVEQGDEPEEFWEAL 609
GV V G+ D D E+E + E +++ +G+E +E EA
Sbjct: 110 ENLGVKVKRGQKYRRVKKMSDDEDDDEEEYGKEEHEKEAIAEEIFQDGEGEEGQEAMEAP 169
Query: 610 GGIPEEKEE 618
PEE+EE
Sbjct: 170 MAPPEEEEE 178
>AK131242-1|BAD18423.1| 268|Homo sapiens protein ( Homo sapiens
cDNA FLJ16159 fis, clone BRCAN2002854, weakly similar
to Human Hsp27 ERE-TATA-binding protein (HET) mRNA. ).
Length = 268
Score = 32.3 bits (70), Expect = 6.5
Identities = 40/145 (27%), Positives = 64/145 (44%), Gaps = 11/145 (7%)
Query: 481 KVPQGKESKHFLSIFKGSLVVLFGSK-DDDYQPQNSKKSYEE-DQTRLFRVEG----TET 534
K +GK KH G V + D + +N K S E D T +E E
Sbjct: 78 KPTKGKGKKHEADELSGDASVEDDAFIKDGEEEENEKGSLAEADHTAHEEMEAHTTVKEA 137
Query: 535 GVDMRAVQV-AEESNVLEDDDVFVLETGSGVYVWNGKDSDPQE-QEAALKFVENVVKDKD 592
D +V + AE++ L+ D +LETG V + + + S P++ Q+A + E KD +
Sbjct: 138 EDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYE 197
Query: 593 VTVVEQGDEPEEFWEALGGIPEEKE 617
+ + + E + + G P EKE
Sbjct: 198 MNANHKDGKKE---DCVKGDPVEKE 219
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.311 0.131 0.375
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 107,764,218
Number of Sequences: 224733
Number of extensions: 4555512
Number of successful extensions: 10100
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 9493
Number of HSP's gapped (non-prelim): 218
length of query: 756
length of database: 73,234,838
effective HSP length: 96
effective length of query: 660
effective length of database: 51,660,470
effective search space: 34095910200
effective search space used: 34095910200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.8 bits)
S2: 69 (31.9 bits)
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