Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001725-TA|BGIBMGA001725-PA|IPR001030|Aconitate
hydratase, N-terminal
(419 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P21399 Cluster: Iron-responsive element-binding protein... 525 e-148
UniRef50_Q4T087 Cluster: Chromosome undetermined SCAF11289, whol... 516 e-145
UniRef50_Q42560 Cluster: Aconitate hydratase 1; n=35; cellular o... 485 e-136
UniRef50_A7DAM6 Cluster: Aconitate hydratase domain protein; n=1... 405 e-111
UniRef50_Q8NQ98 Cluster: Aconitate hydratase; n=10; Bacteria|Rep... 396 e-109
UniRef50_Q9RNH9 Cluster: Aconitase; n=3; Bacteria|Rep: Aconitase... 396 e-109
UniRef50_Q6NH63 Cluster: Aconitate hydratase; n=32; cellular org... 389 e-107
UniRef50_A7CSQ0 Cluster: Aconitate hydratase 1; n=1; Opitutaceae... 378 e-103
UniRef50_Q59938 Cluster: Aconitate hydratase; n=356; cellular or... 376 e-103
UniRef50_A1W553 Cluster: Aconitate hydratase 1 precursor; n=8; P... 373 e-102
UniRef50_Q9I3F5 Cluster: Aconitate hydratase 1; n=98; Bacteria|R... 372 e-102
UniRef50_Q0ADB7 Cluster: Aconitate hydratase 1; n=5; Bacteria|Re... 371 e-101
UniRef50_O08451 Cluster: Aconitate hydratase; n=21; Bacteria|Rep... 371 e-101
UniRef50_Q5V7D3 Cluster: Aconitate hydratase I; n=4; cellular or... 366 e-100
UniRef50_Q5P0Q2 Cluster: Aconitase; n=4; Proteobacteria|Rep: Aco... 362 8e-99
UniRef50_Q4J9H0 Cluster: Aconitate hydratase; n=7; cellular orga... 348 2e-94
UniRef50_A5C294 Cluster: Putative uncharacterized protein; n=1; ... 342 9e-93
UniRef50_Q97Z42 Cluster: Aconitate hydratase; n=3; cellular orga... 329 9e-89
UniRef50_Q125M5 Cluster: Aconitate hydratase-like; n=8; Proteoba... 306 6e-82
UniRef50_P48200 Cluster: Iron-responsive element-binding protein... 305 1e-81
UniRef50_Q7WB80 Cluster: Aconitate hydratase; n=3; Bordetella|Re... 304 2e-81
UniRef50_Q0ZQ48 Cluster: FrbA; n=6; cellular organisms|Rep: FrbA... 304 2e-81
UniRef50_A5WEQ7 Cluster: 2-methylisocitrate dehydratase, Fe/S-de... 284 3e-75
UniRef50_A3BB05 Cluster: Putative uncharacterized protein; n=1; ... 260 6e-68
UniRef50_Q4YCZ3 Cluster: Putative uncharacterized protein; n=1; ... 222 1e-56
UniRef50_A4FHT3 Cluster: Aconitate hydratase 1; n=2; Actinomycet... 148 2e-34
UniRef50_Q3YMK8 Cluster: Iron regulatory protein 2; n=5; Clupeoc... 137 4e-31
UniRef50_P19414 Cluster: Aconitate hydratase, mitochondrial prec... 129 2e-28
UniRef50_UPI00015B4325 Cluster: PREDICTED: similar to aconitase,... 121 3e-26
UniRef50_O13966 Cluster: Aconitate hydratase, mitochondrial prec... 120 9e-26
UniRef50_Q0VKG5 Cluster: Aconitate hydratase; n=2; Bacteria|Rep:... 116 1e-24
UniRef50_Q99798 Cluster: Aconitate hydratase, mitochondrial prec... 113 1e-23
UniRef50_Q0CSK9 Cluster: Aconitate hydratase, mitochondrial; n=2... 111 3e-23
UniRef50_Q74AD1 Cluster: Aconitate hydratase, putative; n=12; Ba... 111 4e-23
UniRef50_O67656 Cluster: Aconitase; n=17; cellular organisms|Rep... 110 6e-23
UniRef50_Q0USA6 Cluster: Putative uncharacterized protein; n=2; ... 108 2e-22
UniRef50_A0RTP9 Cluster: 3-isopropylmalate isomerase/aconitase A... 104 4e-21
UniRef50_Q5V0F1 Cluster: Aconitate hydratase; n=8; cellular orga... 101 4e-20
UniRef50_Q4PB22 Cluster: Putative uncharacterized protein; n=5; ... 98 3e-19
UniRef50_Q9VIE8 Cluster: CG9244-PB; n=37; cellular organisms|Rep... 98 4e-19
UniRef50_Q7NDZ5 Cluster: Aconitate hydratase; n=28; Bacteria|Rep... 95 3e-18
UniRef50_Q2UTF0 Cluster: Aconitase/homoaconitase; n=9; cellular ... 93 9e-18
UniRef50_Q1IMD4 Cluster: Aconitate hydratase-like; n=1; Acidobac... 89 2e-16
UniRef50_A4W1Y9 Cluster: Aconitase A; n=1; Streptococcus suis 98... 89 2e-16
UniRef50_O75944 Cluster: Aconitase; n=34; cellular organisms|Rep... 87 6e-16
UniRef50_Q0C395 Cluster: Putative 3-isopropylmalate dehydratase,... 74 8e-12
UniRef50_A5ZNE1 Cluster: Putative uncharacterized protein; n=1; ... 72 2e-11
UniRef50_Q5K9V9 Cluster: Homoaconitase, mitochondrial precursor;... 67 7e-10
UniRef50_Q89X98 Cluster: 3-isopropylmalate dehydratase large sub... 64 5e-09
UniRef50_P49367 Cluster: Homoaconitase, mitochondrial precursor;... 64 7e-09
UniRef50_UPI00015BAFD3 Cluster: 3-isopropylmalate dehydratase; n... 64 9e-09
UniRef50_A5WGT5 Cluster: 3-isopropylmalate dehydratase, large su... 64 9e-09
UniRef50_A5ZND9 Cluster: Putative uncharacterized protein; n=1; ... 62 3e-08
UniRef50_Q0W1Q4 Cluster: 3-isopropylmalate dehydratase, large su... 62 3e-08
UniRef50_P81291 Cluster: 3-isopropylmalate dehydratase large sub... 61 5e-08
UniRef50_Q8TVF2 Cluster: 3-isopropylmalate dehydratase large sub... 61 6e-08
UniRef50_Q82WI9 Cluster: 3-isopropylmalate dehydratase large sub... 60 1e-07
UniRef50_Q05FR0 Cluster: 3-isopropylmalate dehydratase large sub... 60 1e-07
UniRef50_A4M821 Cluster: Homoaconitate hydratase family protein;... 60 1e-07
UniRef50_A0HK99 Cluster: Aconitate hydratase-like; n=3; Burkhold... 60 1e-07
UniRef50_A6FCI8 Cluster: Isopropylmalate isomerase large subunit... 59 2e-07
UniRef50_P07264 Cluster: 3-isopropylmalate dehydratase; n=473; c... 59 2e-07
UniRef50_A4VXS4 Cluster: 3-isopropylmalate dehydratase large sub... 58 3e-07
UniRef50_Q9WYC7 Cluster: 3-isopropylmalate dehydratase large sub... 58 3e-07
UniRef50_Q4WUL6 Cluster: Homoaconitase, mitochondrial precursor;... 58 6e-07
UniRef50_Q1AVC5 Cluster: Homoaconitate hydratase family protein;... 57 8e-07
UniRef50_A2SQ03 Cluster: 3-isopropylmalate dehydratase; n=5; Met... 56 1e-06
UniRef50_A7NXJ3 Cluster: Chromosome chr5 scaffold_2, whole genom... 56 2e-06
UniRef50_Q2GN26 Cluster: Homoaconitase, mitochondrial precursor;... 55 3e-06
UniRef50_O67078 Cluster: 3-isopropylmalate dehydratase large sub... 55 3e-06
UniRef50_Q65VS0 Cluster: 3-isopropylmalate dehydratase large sub... 55 3e-06
UniRef50_Q0PQM4 Cluster: Aconitase A; n=1; Endoriftia persephone... 55 4e-06
UniRef50_Q5AVN8 Cluster: Putative uncharacterized protein; n=1; ... 55 4e-06
UniRef50_A6DRT0 Cluster: 3-isopropylmalate dehydratase; n=4; Bac... 54 5e-06
UniRef50_A0ZF76 Cluster: 3-isopropylmalate dehydratase, LeuC sub... 54 5e-06
UniRef50_Q5FUG3 Cluster: 3-isopropylmalate dehydratase large sub... 54 5e-06
UniRef50_Q6L0K5 Cluster: 3-isopropylmalate dehydratase large sub... 54 9e-06
UniRef50_A0RXN9 Cluster: 3-isopropylmalate dehydratase large sub... 53 1e-05
UniRef50_A3LRP7 Cluster: 3-isopropylmalate dehydratase; n=1; Pic... 53 2e-05
UniRef50_Q1LAU9 Cluster: Homoaconitate hydratase family protein;... 52 3e-05
UniRef50_Q9RTI6 Cluster: 3-isopropylmalate dehydratase large sub... 52 4e-05
UniRef50_UPI00006D922D Cluster: COG0065: 3-isopropylmalate dehyd... 50 9e-05
UniRef50_Q8PUG1 Cluster: 3-isopropylmalate dehydratase large sub... 50 9e-05
UniRef50_A0UZT1 Cluster: Homoaconitate hydratase family protein;... 50 2e-04
UniRef50_Q58409 Cluster: 3-isopropylmalate dehydratase large sub... 50 2e-04
UniRef50_Q7WPW8 Cluster: Aconitase family protein; n=2; Bordetel... 49 3e-04
UniRef50_Q4AFY9 Cluster: Aconitate hydratase, C-terminal:Aconita... 49 3e-04
UniRef50_Q4WBR0 Cluster: Aconitase family protein; n=7; Pezizomy... 48 3e-04
UniRef50_Q8KER8 Cluster: 3-isopropylmalate dehydratase, large su... 47 8e-04
UniRef50_Q74BX5 Cluster: 3-isopropylmalate dehydratase, large su... 47 8e-04
UniRef50_Q18GT3 Cluster: 3-isopropylmalate dehydratase large sub... 47 8e-04
UniRef50_A6NVP4 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_Q08N42 Cluster: Aconitate hydratase; n=2; Cystobacterin... 46 0.002
UniRef50_O53237 Cluster: 3-isopropylmalate dehydratase large sub... 46 0.002
UniRef50_A7H0L8 Cluster: 3-isopropylmalate dehydratase, large su... 45 0.003
UniRef50_A7NXA9 Cluster: Chromosome chr5 scaffold_2, whole genom... 45 0.004
UniRef50_Q9RTY9 Cluster: 3-isopropylmalate dehydratase large sub... 43 0.017
UniRef50_Q5PXM8 Cluster: Aconitase A; n=3; Gammaproteobacteria|R... 42 0.023
UniRef50_P75764 Cluster: Uncharacterized protein ybhJ; n=32; Bac... 42 0.023
UniRef50_Q8TW29 Cluster: 3-isopropylmalate dehydratase large sub... 42 0.023
UniRef50_Q6KZ03 Cluster: 3-isopropylmalate dehydratase large sub... 40 0.092
UniRef50_UPI00003837C5 Cluster: COG1048: Aconitase A; n=1; Magne... 40 0.12
UniRef50_Q6A800 Cluster: 3-isopropylmalate dehydratase large sub... 40 0.12
UniRef50_Q8U0C0 Cluster: 3-isopropylmalate dehydratase large sub... 39 0.21
UniRef50_Q938C9 Cluster: 3-isopropylmalate dehydratase large sub... 38 0.37
UniRef50_Q97VY2 Cluster: 3-isopropylmalate dehydratase large sub... 36 2.0
UniRef50_Q1Q5P1 Cluster: Similar to NAD(P) oxidoreductase, FAD-c... 36 2.6
UniRef50_A3UII1 Cluster: Putative 22-domain light-and oxygen-sen... 36 2.6
UniRef50_UPI000058674B Cluster: PREDICTED: similar to Tnfaip3-pr... 35 3.5
UniRef50_Q4VDG4 Cluster: Putative 3-isopropylmalate dehydratase ... 35 3.5
UniRef50_Q76YZ8 Cluster: Putative uncharacterized protein; n=1; ... 35 3.5
UniRef50_Q9ZD92 Cluster: ATP-dependent protease La; n=10; Ricket... 35 4.6
UniRef50_UPI0000E462A1 Cluster: PREDICTED: similar to LOC495937 ... 34 6.1
UniRef50_A2DTK6 Cluster: Putative uncharacterized protein; n=1; ... 34 6.1
UniRef50_A6XPX3 Cluster: Putative uncharacterized protein; n=1; ... 34 6.1
UniRef50_A2F2D5 Cluster: ATPase, AAA family protein; n=1; Tricho... 34 8.0
>UniRef50_P21399 Cluster: Iron-responsive element-binding protein 1;
n=116; cellular organisms|Rep: Iron-responsive
element-binding protein 1 - Homo sapiens (Human)
Length = 889
Score = 525 bits (1295), Expect = e-148
Identities = 252/397 (63%), Positives = 310/397 (78%), Gaps = 4/397 (1%)
Query: 5 TNPYQKLLKTIEINGSTYTYYDVSAL-GPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVS 63
+NP+ L + ++ +++++ L +Y RLPFSIRVLLE+ +RNCD F V ++D+
Sbjct: 2 SNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIE 61
Query: 64 NVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICP 123
N+L W Q +++E+ FKPARVILQD TGVPAVVDFAAMRDAVK LGGDP++INP+CP
Sbjct: 62 NILHWNVTQ--HKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCP 119
Query: 124 ADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQ 183
ADLVIDHS+QVDF R D+L KNQDLEF RN+ERF+FLKWG+QAF NM I+PPGSGI+HQ
Sbjct: 120 ADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQ 179
Query: 184 VNLEYLARVVFTGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLL 242
VNLEYLARVVF +PDS+VGTDSHTTMI+ IEAEAVMLGQ ISM+L
Sbjct: 180 VNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVL 239
Query: 243 PKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANM 302
P+V+GY+L+G+ +PL TSTD+VLTITKHLR +GVVGKFVEFFGPGV LSIADRAT+ANM
Sbjct: 240 PQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANM 299
Query: 303 CPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVV 362
CPE+GAT A FPVD S+ YL QT R +EK+ I+ YL+A FRD+ +P QDP F++VV
Sbjct: 300 CPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVV 359
Query: 363 ELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNK 399
ELDL VV SGPKRPQD+V+V+ MKKDF+ CL K
Sbjct: 360 ELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAK 396
>UniRef50_Q4T087 Cluster: Chromosome undetermined SCAF11289, whole
genome shotgun sequence; n=3; Euteleostomi|Rep:
Chromosome undetermined SCAF11289, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 894
Score = 516 bits (1273), Expect = e-145
Identities = 253/411 (61%), Positives = 304/411 (73%), Gaps = 4/411 (0%)
Query: 11 LLKTIEINGSTYTYYDVSALGP-KYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWE 69
LL+ ++ + ++++S LG +Y+RLPFSIRVLLE+ VR CD F V DV N+LDW+
Sbjct: 1 LLEPLDPSAPGQRFFNLSKLGDARYERLPFSIRVLLEAAVRTCDCFLVKPSDVENILDWK 60
Query: 70 SKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVID 129
Q SVE+ F+PARVILQD TGVPAVVD AAMRDAVK LGGDP+R+NP+CPADLVID
Sbjct: 61 RTQ--TRSVEVPFRPARVILQDFTGVPAVVDLAAMRDAVKQLGGDPERVNPVCPADLVID 118
Query: 130 HSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYL 189
HS+QVDF R D+L +NQDLEF RN+ERFQFLKWG++AF NM I+PPGSGIVHQVNLEYL
Sbjct: 119 HSIQVDFNRKSDSLRRNQDLEFERNRERFQFLKWGSRAFRNMRIIPPGSGIVHQVNLEYL 178
Query: 190 ARVVFTGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGY 248
ARVVF L++PDSVVGTDSHTTMI+ IEAEAVMLGQ ISM+LP+VVGY
Sbjct: 179 ARVVFQRDGLVYPDSVVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVVGY 238
Query: 249 KLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGA 308
+L G + TSTD+VLT+TKHLR +GVVGKFVEFFGPGV LSIADRAT+ANMCPE+GA
Sbjct: 239 RLSGVPDGFVTSTDIVLTVTKHLRQVGVVGKFVEFFGPGVARLSIADRATIANMCPEYGA 298
Query: 309 TLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGD 368
T A FPVD S+ YL QT R E + + YL+A RDY + QDP F++VVELDLG
Sbjct: 299 TAAFFPVDDASIRYLEQTGREPETLATVRDYLKAVGMLRDYADAGQDPEFTQVVELDLGT 358
Query: 369 VVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKPVPIAILSGVQEHVLDFPYQ 419
V SGPKRPQDRV ++ MK+DF+ CL K + H P++
Sbjct: 359 VAPCCSGPKRPQDRVPLSQMKEDFESCLGAKQGFKGFQVAAEHHAATVPFR 409
>UniRef50_Q42560 Cluster: Aconitate hydratase 1; n=35; cellular
organisms|Rep: Aconitate hydratase 1 - Arabidopsis
thaliana (Mouse-ear cress)
Length = 898
Score = 485 bits (1197), Expect = e-136
Identities = 241/400 (60%), Positives = 294/400 (73%), Gaps = 6/400 (1%)
Query: 4 STNPYQKLLKTIEI--NGSTYTYYDVSALG-PKYDRLPFSIRVLLESCVRNCDNFQVLEK 60
S NP++ +LK +E G YY + AL P+ D+LP+SIR+LLES +RNCD FQV K
Sbjct: 3 SENPFRSILKALEKPDGGEFGNYYSLPALNDPRIDKLPYSIRILLESAIRNCDEFQVKSK 62
Query: 61 DVSNVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINP 120
DV +LDWE+ + + VEI FKPARV+LQD TGVPAVVD A MRDA+ +LGGD ++INP
Sbjct: 63 DVEKILDWENT--SPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINP 120
Query: 121 ICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGI 180
+ P DLVIDHSVQVD AR+ +A+ N +LEF RNKERF FLKWG+ AF NML+VPPGSGI
Sbjct: 121 LVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSNAFHNMLVVPPGSGI 180
Query: 181 VHQVNLEYLARVVF-TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAIS 239
VHQVNLEYLARVVF T LL+PDSVVGTDSHTTMI+ IEAEA MLGQ +S
Sbjct: 181 VHQVNLEYLARVVFNTNGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMS 240
Query: 240 MLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATV 299
M+LP VVG+KL G+L T+TDLVLT+T+ LR GVVGKFVEF G G+ LS+ADRAT+
Sbjct: 241 MVLPGVVGFKLTGKLRDGMTATDLVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATI 300
Query: 300 ANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFS 359
ANM PE+GAT+ FPVD +L+YL T R + + +IE+YLRA K F DY+ PE V+S
Sbjct: 301 ANMSPEYGATMGFFPVDHVTLQYLRLTGRSDDTVSMIEAYLRANKMFVDYSEPESKTVYS 360
Query: 360 EVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNK 399
+EL+L DV VSGPKRP DRV + MK D+ CL N+
Sbjct: 361 SCLELNLEDVEPCVSGPKRPHDRVPLKEMKADWHSCLDNR 400
>UniRef50_A7DAM6 Cluster: Aconitate hydratase domain protein; n=1;
Methylobacterium extorquens PA1|Rep: Aconitate hydratase
domain protein - Methylobacterium extorquens PA1
Length = 908
Score = 405 bits (997), Expect = e-111
Identities = 201/396 (50%), Positives = 269/396 (67%), Gaps = 12/396 (3%)
Query: 10 KLLKTIEINGSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKDVSNV 65
K +T++ G TYTYY + LPFS++V+LE+ +R D+ V D+
Sbjct: 8 KARQTLQAGGKTYTYYSIPEAEKNGLADSTALPFSMKVILENLLRFEDDRSVKRADIEAA 67
Query: 66 LDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPAD 125
+ W QG E+ EIAF+P+RV++QD TGVPAVVD AAMRDA+ LGGDP +INP+ P D
Sbjct: 68 VAWLGNQGRAET-EIAFRPSRVLMQDFTGVPAVVDLAAMRDAMVALGGDPQKINPLVPVD 126
Query: 126 LVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVN 185
LVIDHSV VD TP AL N LE+ RN ER+ FLKWG AFDN +VPPG+GI HQVN
Sbjct: 127 LVIDHSVIVDEFGTPKALGDNVALEYARNGERYTFLKWGQSAFDNFSVVPPGTGICHQVN 186
Query: 186 LEYLARVVFT-----GPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISM 240
LEYL++ V+T + +PDS+VGTDSHTTM+N IEAEA MLGQ +SM
Sbjct: 187 LEYLSQTVWTRTEDGAEIAYPDSLVGTDSHTTMVNGLAVLGWGVGGIEAEAAMLGQPLSM 246
Query: 241 LLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVA 300
L+P+V+G+KL G+L T+TDLVLT+T+ LR GVVGKFVEF+GPG+ + +ADRAT++
Sbjct: 247 LIPEVIGFKLSGKLPEGTTATDLVLTVTQMLRKKGVVGKFVEFYGPGLDDMPVADRATIS 306
Query: 301 NMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSE 360
NM PE+GAT FP+D +++++L T R ++I ++E+Y +A +RD P DPVF++
Sbjct: 307 NMAPEYGATCGFFPIDQKTIDFLKVTGRQDDRIALVEAYAKAQGMWRDAKTP--DPVFTD 364
Query: 361 VVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCL 396
+ELD+ V S++GPKRPQDRV + K F D +
Sbjct: 365 TLELDMSTVRPSLAGPKRPQDRVLLDSAKAGFADSM 400
>UniRef50_Q8NQ98 Cluster: Aconitate hydratase; n=10; Bacteria|Rep:
Aconitate hydratase - Corynebacterium glutamicum
(Brevibacterium flavum)
Length = 939
Score = 396 bits (976), Expect = e-109
Identities = 190/381 (49%), Positives = 272/381 (71%), Gaps = 6/381 (1%)
Query: 14 TIEINGSTYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQG 73
T+E+ +Y Y+ +SA+ P ++LP+S++VL E+ +R D + + + + +W++
Sbjct: 13 TLEVGDKSYDYFALSAV-PGMEKLPYSLKVLGENLLRTEDGANITNEHIEAIANWDAS-- 69
Query: 74 NEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQ 133
++ S+EI F PARV++QD TGVP VVD A MR+AV LGGDP+ +NP+ PA++VIDHSV
Sbjct: 70 SDPSIEIQFTPARVLMQDFTGVPCVVDLATMREAVAALGGDPNDVNPLNPAEMVIDHSVI 129
Query: 134 VDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVV 193
V+ PDAL KN ++E+ RN+ER+QFL+WG+++F N +VPPG+GIVHQVN+EYLARVV
Sbjct: 130 VEAFGRPDALAKNVEIEYERNEERYQFLRWGSESFSNFRVVPPGTGIVHQVNIEYLARVV 189
Query: 194 FTGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVG 252
F L +PD+ +GTDSHTTM N IEAEA MLGQ +SML+P+VVG+KL G
Sbjct: 190 FDNEGLAYPDTCIGTDSHTTMENGLGILGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTG 249
Query: 253 ELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAH 312
E+ T+TD+VLTIT+ LR GVV KFVEF+G GV A+ +A+RAT+ NM PEFG+T A
Sbjct: 250 EIPVGVTATDVVLTITEMLRDHGVVQKFVEFYGSGVKAVPLANRATIGNMSPEFGSTCAM 309
Query: 313 FPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTS 372
FP+D + +YL T RP+E++ ++E+Y +A + D E + +SE +ELDL VV S
Sbjct: 310 FPIDEETTKYLRLTGRPEEQVALVEAYAKAQGMWLDEDTVEAE--YSEYLELDLSTVVPS 367
Query: 373 VSGPKRPQDRVSVAIMKKDFQ 393
++GPKRPQDR+ ++ K+ F+
Sbjct: 368 IAGPKRPQDRILLSEAKEQFR 388
>UniRef50_Q9RNH9 Cluster: Aconitase; n=3; Bacteria|Rep: Aconitase -
Streptomyces coelicolor
Length = 904
Score = 396 bits (974), Expect = e-109
Identities = 198/386 (51%), Positives = 268/386 (69%), Gaps = 7/386 (1%)
Query: 14 TIEINGSTYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQG 73
T+++ +Y + + + RLP+S++VLLE+ +R D + + + W+S+
Sbjct: 11 TLQVGDESYEIFRLDKVEGSA-RLPYSLKVLLENLLRTEDGANITADHIRALGGWDSQA- 68
Query: 74 NEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQ 133
+ S EI F PARVI+QD TGVP VVD A MR+AVK+LGGDP++INP+ PA++VIDHSV
Sbjct: 69 -QPSQEIQFTPARVIMQDFTGVPCVVDLATMREAVKELGGDPNKINPLSPAEMVIDHSVI 127
Query: 134 VDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVV 193
D T DA +N DLE+ RNKER+QFL+WG AFD+ +VPPG+GIVHQVN+E+LARVV
Sbjct: 128 ADKFGTNDAFQQNVDLEYGRNKERYQFLRWGQTAFDDFKVVPPGTGIVHQVNIEHLARVV 187
Query: 194 FT-GPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVG 252
T +PD++VGTDSHTTM+N IEAEA MLGQ +SML+P+VVG+KL G
Sbjct: 188 MTRDGKAYPDTLVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTG 247
Query: 253 ELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAH 312
EL P T+TDLVLTIT+ LR GVVGKFVEF+G GV A S+A+RAT+ NM PEFG+T A
Sbjct: 248 ELTPGTTATDLVLTITEMLRKHGVVGKFVEFYGEGVAATSLANRATIGNMSPEFGSTAAI 307
Query: 313 FPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTS 372
FPVD +L Y+ T R ++ ++E+Y K+ + +P+ +P FSE +ELDL VV S
Sbjct: 308 FPVDDETLNYMRLTGRSAHQVALVEAY---AKEQGLWLDPKAEPDFSEKLELDLSTVVPS 364
Query: 373 VSGPKRPQDRVSVAIMKKDFQDCLTN 398
++GPKRPQDR+ +A + F+ + N
Sbjct: 365 IAGPKRPQDRIVLANAAEQFKQDVRN 390
>UniRef50_Q6NH63 Cluster: Aconitate hydratase; n=32; cellular
organisms|Rep: Aconitate hydratase - Corynebacterium
diphtheriae
Length = 934
Score = 389 bits (958), Expect = e-107
Identities = 187/382 (48%), Positives = 271/382 (70%), Gaps = 6/382 (1%)
Query: 13 KTIEINGSTYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQ 72
+T+E+ +Y Y+ +SA+ ++LP+S++VL E+ +R D + ++ + +W+
Sbjct: 12 QTLEVGDKSYDYFALSAV-KGMEKLPYSLKVLGENLLRTEDGANITADHINAIANWDPSA 70
Query: 73 GNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSV 132
E S+EI F PARV++QD TGVP VVD A MR+AVK LGGDPD++NP+ PA++VIDHSV
Sbjct: 71 --EPSIEIQFTPARVLMQDFTGVPCVVDLATMREAVKTLGGDPDKVNPLNPAEMVIDHSV 128
Query: 133 QVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARV 192
++ + AL KN ++E+ RN+ER+QFL+WG++AF N +VPPG+GIVHQVN+E LARV
Sbjct: 129 IIEAFGSTLALAKNVEIEYERNEERYQFLRWGSKAFSNFRVVPPGTGIVHQVNIENLARV 188
Query: 193 VF-TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLV 251
VF L +PD+ +GTDSHTTM N IEAEA MLGQ +SML+P+VVG+KL
Sbjct: 189 VFDNNGLAYPDTCIGTDSHTTMENGLGILGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLT 248
Query: 252 GELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLA 311
GE+ T+TD+VLTIT+ LR GVV KFVEF+G GV ++ +A+RAT+ NM PEFG+T A
Sbjct: 249 GEIPAGVTATDVVLTITEMLREHGVVQKFVEFYGNGVKSIPLANRATIGNMSPEFGSTCA 308
Query: 312 HFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVT 371
FP+D +++Y+H T R +E++ ++E+Y +A + + PE + +SE +ELDL VV
Sbjct: 309 IFPIDEETVKYMHLTGRSEEQVALVEAYAKAQGMWLEQDAPEAE--YSEYLELDLSTVVP 366
Query: 372 SVSGPKRPQDRVSVAIMKKDFQ 393
S++GPKRPQDR+ + K+ F+
Sbjct: 367 SIAGPKRPQDRILLTEAKEQFR 388
>UniRef50_A7CSQ0 Cluster: Aconitate hydratase 1; n=1; Opitutaceae
bacterium TAV2|Rep: Aconitate hydratase 1 - Opitutaceae
bacterium TAV2
Length = 965
Score = 378 bits (930), Expect = e-103
Identities = 198/403 (49%), Positives = 259/403 (64%), Gaps = 14/403 (3%)
Query: 6 NPYQKLLKTIEINGSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKD 61
NP+ L + +NG ++ YY + AL +RLP SIR++LES +RNCD +V E+
Sbjct: 8 NPFNTL-SSFSVNGVSHPYYSLPALKKSGFDNINRLPVSIRLVLESLLRNCDGKRVSEQA 66
Query: 62 VSNVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPI 121
+ ++ W +K E EI F AR++LQD TGVP +VD AAMR AV LG +P I P+
Sbjct: 67 IRDLATWAAKAPRTE--EIPFVVARIVLQDFTGVPLLVDLAAMRSAVARLGKNPKIIEPL 124
Query: 122 CPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIV 181
P DLV+DHSVQVDFA +P A +N +LEF RN+ER+QFLKWG QAFD +VPPG GIV
Sbjct: 125 VPVDLVVDHSVQVDFAGSPAAFAQNLELEFTRNRERYQFLKWGMQAFDTFKVVPPGIGIV 184
Query: 182 HQVNLEYLARVVF--TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAIS 239
HQVNLEYLA+ V + +PD++VGTDSHTTMIN IEAEA MLGQ +
Sbjct: 185 HQVNLEYLAQGVLKDANSICYPDTLVGTDSHTTMINGIGIVGWGVGGIEAEAGMLGQPVY 244
Query: 240 MLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATV 299
L P VVG L G L T+TDL LT+T+ LR VVGKFVEF+GPG AL + DRAT+
Sbjct: 245 FLTPDVVGVYLTGALREGVTATDLALTLTQLLRKAKVVGKFVEFYGPGAAALPVVDRATI 304
Query: 300 ANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPV-F 358
ANM PE+GAT+ FP+DA YL T R + +++ E+Y RA + P+Q + +
Sbjct: 305 ANMAPEYGATMGFFPIDAECTNYLRATGRDEHHVELYEAYYRAQGL---WGIPQQGDIDY 361
Query: 359 SEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKPV 401
+ + LDL V SV+GPKRPQDR+ + +K +F ++PV
Sbjct: 362 TVELSLDLATVTPSVAGPKRPQDRIELPALKDEFHAAF-SRPV 403
>UniRef50_Q59938 Cluster: Aconitate hydratase; n=356; cellular
organisms|Rep: Aconitate hydratase - Streptococcus
mutans
Length = 888
Score = 376 bits (925), Expect = e-103
Identities = 191/391 (48%), Positives = 252/391 (64%), Gaps = 11/391 (2%)
Query: 14 TIEINGSTYTYYDVSALGPKYD----RLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWE 69
T +N Y Y D+ YD LP++I++LLES +R D+ V + ++ + +
Sbjct: 7 TFTLNRQKYHYIDLVKASKDYDIELDSLPYTIKILLESLLRKHDDICVTKNNIETLFHYN 66
Query: 70 SKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVID 129
SK E + FKP+RVILQD TGVP VVD A+MRDAV + GG PD INP P DLVID
Sbjct: 67 SKAPQGE---VPFKPSRVILQDFTGVPVVVDLASMRDAVVENGGSPDLINPEIPVDLVID 123
Query: 130 HSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYL 189
HSVQVDF DA + N DLEF RN ER++FLKW + F+N VPP +GI+HQVNLE+L
Sbjct: 124 HSVQVDFFGNQDAFDANIDLEFERNNERYEFLKWAEKTFENYRAVPPATGIIHQVNLEFL 183
Query: 190 ARVVFTGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGY 248
+ V+ L+PDS+ GTDSHTTMIN IEAEA MLG+A +P+V+G
Sbjct: 184 SDVIINKDGFLYPDSMFGTDSHTTMINGIGVLGWGVGGIEAEAAMLGEASYFPIPEVIGV 243
Query: 249 KLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGA 308
+L GEL +AT+TDL L +T+ LR VVGKFVEFFGPG+ LS+ADRATVANM PE+GA
Sbjct: 244 RLYGELPKVATATDLALKVTQKLRLENVVGKFVEFFGPGLAGLSLADRATVANMAPEYGA 303
Query: 309 TLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGD 368
T +FP+D +L Y+ TNR E I + + Y + + D TN P ++++VE+DL
Sbjct: 304 TCGYFPIDDETLNYMKLTNRSAEHIALTKEYAKRNHLYHDMTNL---PSYTKIVEIDLSA 360
Query: 369 VVTSVSGPKRPQDRVSVAIMKKDFQDCLTNK 399
+ S+SGPKRPQD + + K++FQ L +
Sbjct: 361 IKPSISGPKRPQDLIELGQAKEEFQASLVRQ 391
>UniRef50_A1W553 Cluster: Aconitate hydratase 1 precursor; n=8;
Proteobacteria|Rep: Aconitate hydratase 1 precursor -
Acidovorax sp. (strain JS42)
Length = 972
Score = 373 bits (917), Expect = e-102
Identities = 197/410 (48%), Positives = 260/410 (63%), Gaps = 14/410 (3%)
Query: 1 MAGSTNPYQKLLKTIEI----NGSTYTYYDVSALG---PKYDRLPFSIRVLLESCVRNCD 53
MA S NP T+ G + +Y + AL P +RLP S+R++LES +RNCD
Sbjct: 1 MAASRNPAHAFASTLATFATAAGKSGKFYSLPALARQFPGVNRLPVSLRIVLESVLRNCD 60
Query: 54 NFQVLEKDVSNVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGG 113
++ + V + W ++ EI F +RV+LQD TGVP +VD AAMR + LG
Sbjct: 61 GRRITAEHVEQLARWAPNAPRKD--EIPFVVSRVVLQDFTGVPLLVDLAAMRSVAQRLGH 118
Query: 114 DPDRINPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLI 173
+P +I P+ P DLV+DHS+ VD+ T AL+ N LEF RN+ER++F+KWG QAF +
Sbjct: 119 NPRKIEPLVPVDLVVDHSIMVDYYGTKKALDLNMKLEFQRNRERYEFMKWGMQAFSTFGV 178
Query: 174 VPPGSGIVHQVNLEYLARVVFTGP--LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEA 231
VPPG GIVHQVNLEYLAR V G + +PD++VGTDSHTTMIN IEAEA
Sbjct: 179 VPPGFGIVHQVNLEYLARGVHKGNDGVYYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEA 238
Query: 232 VMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGAL 291
MLGQ + L P VVG++L G+L T+TDLVLT+T+ LR VVGKFVEFFG G L
Sbjct: 239 AMLGQPVYFLTPDVVGFELSGQLREGVTATDLVLTVTEILRREKVVGKFVEFFGEGTRTL 298
Query: 292 SIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTN 351
++ DRAT+ NM PE+GAT+ FPVD ++++Y T R K +ID E+Y RA F
Sbjct: 299 ALPDRATIGNMAPEYGATMGFFPVDEKTIDYFRGTGRTKAEIDAFEAYFRAQGLFGVPRA 358
Query: 352 PEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKPV 401
E D +S+VV LDLGDV S++GPKRPQDR+ + + + F + L +KPV
Sbjct: 359 GEID--YSQVVRLDLGDVTPSLAGPKRPQDRIELGNVCRQFAE-LFSKPV 405
>UniRef50_Q9I3F5 Cluster: Aconitate hydratase 1; n=98; Bacteria|Rep:
Aconitate hydratase 1 - Pseudomonas aeruginosa
Length = 910
Score = 372 bits (916), Expect = e-102
Identities = 190/396 (47%), Positives = 261/396 (65%), Gaps = 15/396 (3%)
Query: 10 KLLKTIEINGSTYTYYDVS----ALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNV 65
K L+++ ++G TY YY + LG +LP S++VLLE+ +R D V D+ +
Sbjct: 8 KTLRSLAVDGKTYHYYSLPEAARTLGD-LGKLPMSLKVLLENLLRWEDGSTVTGDDLKAL 66
Query: 66 LDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPAD 125
W ++ ++ EI ++PARV++QD TGVPAVVD AAMR A+ GGDP +INP+ P D
Sbjct: 67 AGWLRERRSDR--EIQYRPARVLMQDFTGVPAVVDLAAMRAAMAKAGGDPQKINPLSPVD 124
Query: 126 LVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVN 185
LVIDHSV VD + A +N ++E RN ER+ FL+WG AFDN +VPPG+GI HQVN
Sbjct: 125 LVIDHSVMVDKFASESAFEQNVEIEMQRNGERYAFLRWGQNAFDNFSVVPPGTGICHQVN 184
Query: 186 LEYLARVVFTGP-----LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISM 240
LEYL R V+T PD++VGTDSHTTMIN IEAEA MLGQ +SM
Sbjct: 185 LEYLGRTVWTKDEDGRTYAFPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSM 244
Query: 241 LLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVA 300
L+P+V+G+KL G+L T+TDLVLT+T+ LR GVVGKFVEF+G G+ L +ADRAT+A
Sbjct: 245 LIPEVIGFKLTGKLREGITATDLVLTVTQMLRKKGVVGKFVEFYGDGLADLPLADRATIA 304
Query: 301 NMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSE 360
NM PE+GAT FPVD +L YL + RP+ + ++E+Y + +R+ +PVF++
Sbjct: 305 NMAPEYGATCGFFPVDEITLGYLRLSGRPESTVKLVEAYSKEQGLWRE---KGHEPVFTD 361
Query: 361 VVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCL 396
+ LD+G+V S++GPKRPQDRV++ + F + L
Sbjct: 362 TLHLDMGEVEASLAGPKRPQDRVALQNVASAFNEFL 397
>UniRef50_Q0ADB7 Cluster: Aconitate hydratase 1; n=5; Bacteria|Rep:
Aconitate hydratase 1 - Nitrosomonas eutropha (strain
C71)
Length = 947
Score = 371 bits (912), Expect = e-101
Identities = 193/396 (48%), Positives = 255/396 (64%), Gaps = 11/396 (2%)
Query: 12 LKTIEI-NGSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVL 66
L T+ + NG T +Y + AL RLP SIR++LES +RN D+ ++ E V +
Sbjct: 9 LSTLPLSNGETIQFYSLPALEAAGLGTISRLPVSIRIILESILRNYDDKKITEAHVKQLA 68
Query: 67 DWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADL 126
W+ + E + EI F AR++LQD TG+P +VD AAMR K LG +P+ I P+ P DL
Sbjct: 69 SWQPRA--ERTQEIPFVVARIVLQDFTGIPLLVDLAAMRSVAKRLGKNPELIEPLVPVDL 126
Query: 127 VIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNL 186
V+DHS+Q+D+ AL +N ++EF RN+ER+QF+KWG QAFD +VPPG GIVHQVNL
Sbjct: 127 VVDHSIQIDYYGDSQALARNMEIEFQRNRERYQFIKWGMQAFDTFGVVPPGIGIVHQVNL 186
Query: 187 EYLARVVFTGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKV 245
EYLAR V ++PD++VGTDSHTTMIN IEAEA MLGQ I L P V
Sbjct: 187 EYLARGVHQKDGFIYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAGMLGQPIYFLTPDV 246
Query: 246 VGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPE 305
VG L G L T+TDLVLT+T+ LR VVGKFVEFFG GV LS+ DRAT+ANM PE
Sbjct: 247 VGVNLTGHLQEGVTATDLVLTVTEMLRRANVVGKFVEFFGEGVTLLSLPDRATIANMAPE 306
Query: 306 FGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELD 365
+GAT+ FPVD +L Y T R +E+ID E Y +A F + + D +S+ + LD
Sbjct: 307 YGATMGFFPVDDATLAYFRYTGRTEEEIDAFERYFKAQGLFGMPRHGDID--YSQELALD 364
Query: 366 LGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKPV 401
L + S++GPKRPQDR+++ +K F + L +KP+
Sbjct: 365 LSTITPSLAGPKRPQDRIALKDLKSTFTE-LFSKPI 399
>UniRef50_O08451 Cluster: Aconitate hydratase; n=21; Bacteria|Rep:
Aconitate hydratase - Mycobacterium avium
Length = 961
Score = 371 bits (912), Expect = e-101
Identities = 179/381 (46%), Positives = 258/381 (67%), Gaps = 8/381 (2%)
Query: 15 IEINGSTYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGN 74
+++ +Y Y + A+ P ++LP+S++VL E+ +RN D + + + + +W+ K G
Sbjct: 41 VKVGDKSYQIYRLDAV-PNTEKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAG- 98
Query: 75 EESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQV 134
S+EI + PARV++QD TGVP +VD A MR+A+ DLGG+P+++NP+ PADLVIDHSV
Sbjct: 99 -ASIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPEKVNPLAPADLVIDHSVIA 157
Query: 135 DFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVF 194
D T DA +N ++E+ RN ER+QFL+W AF + +VPP IVHQVN+EYLARVV
Sbjct: 158 DLFGTADAFERNVEIEYQRNGERYQFLRWLQGAFSDFKVVPPRR-IVHQVNIEYLARVVM 216
Query: 195 TGP-LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGE 253
+ +PD+ VGTDSHTTM+N IEAEA MLGQ +SML+P+VVG+KL GE
Sbjct: 217 ERVGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGE 276
Query: 254 LNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHF 313
+TD+VLT+T+ GVVGKFVEF+G GV + +A+RAT+ NM PEFG+T A F
Sbjct: 277 DPAPGAATDVVLTVTEICAKHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIF 336
Query: 314 PVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSV 373
P+D +++YL T R E++ ++E+Y + + D P +P FSE +ELDL VV S+
Sbjct: 337 PIDQETIDYLKFTGRNAEQVALVETYAKEQGLWHD---PAHEPAFSEYLELDLSQVVPSI 393
Query: 374 SGPKRPQDRVSVAIMKKDFQD 394
+GPKRPQDR++++ K F++
Sbjct: 394 AGPKRPQDRIALSQAKSVFRE 414
>UniRef50_Q5V7D3 Cluster: Aconitate hydratase I; n=4; cellular
organisms|Rep: Aconitate hydratase I - Haloarcula
marismortui (Halobacterium marismortui)
Length = 927
Score = 366 bits (900), Expect = e-100
Identities = 194/394 (49%), Positives = 255/394 (64%), Gaps = 17/394 (4%)
Query: 12 LKTIEINGSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLD 67
++ ++++G+TY D+ AL + D LP SIR+LLES +RN D V DV N
Sbjct: 10 VRELDVDGTTYKMADLRALEEQGLCDLDTLPVSIRILLESVLRNADGETVTAADVKNAAG 69
Query: 68 WESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLV 127
W+ + E+ F P+RV+LQDLTGVPAVVD AA+R V DP + P P DLV
Sbjct: 70 WKP---DVPDAEVPFSPSRVVLQDLTGVPAVVDLAALRSEVDRKDRDPTLVEPEIPIDLV 126
Query: 128 IDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLE 187
IDHSVQVD+ + DA KN +LE+ RN ER++ +KW AF+N +VPPG+GIVHQVNLE
Sbjct: 127 IDHSVQVDYFDSEDAYEKNVELEYERNAERYRAIKWAQNAFENFNVVPPGTGIVHQVNLE 186
Query: 188 YLARVVFTGPL-----LHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLL 242
+L RVV L PD++VGTDSHT MI IEAEA MLGQ ++M L
Sbjct: 187 HLGRVVHAREQDGENWLLPDTLVGTDSHTPMIGGIGVVGWGVGGIEAEAAMLGQPVTMKL 246
Query: 243 PKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANM 302
P+VVG +L GEL AT+TDLVL IT+ LR +GVV +FVEFFGPGV L++ DRAT+ANM
Sbjct: 247 PEVVGVRLEGELPEGATATDLVLHITERLREVGVVDRFVEFFGPGVENLTVPDRATIANM 306
Query: 303 CPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVV 362
PE G+T++ FPVD ++LEYL T R + +D++ YL A F EQ+P ++EVV
Sbjct: 307 APEQGSTISMFPVDEQTLEYLELTGRDPDHVDLVREYLEAQGLF-----GEQEPEYTEVV 361
Query: 363 ELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCL 396
E DL V S++G KRPQDR+ + +K+ F+ L
Sbjct: 362 EFDLSTVEPSLAGHKRPQDRIPMGDVKQSFRGLL 395
>UniRef50_Q5P0Q2 Cluster: Aconitase; n=4; Proteobacteria|Rep:
Aconitase - Azoarcus sp. (strain EbN1) (Aromatoleum
aromaticum (strain EbN1))
Length = 905
Score = 362 bits (891), Expect = 8e-99
Identities = 192/391 (49%), Positives = 252/391 (64%), Gaps = 14/391 (3%)
Query: 19 GSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGN 74
G + YY + AL RLP SIR++LE+ +R+CD ++ E V + W +
Sbjct: 17 GRSGRYYSLPALETAGVATVSRLPVSIRIVLEAVLRHCDGRKITEDHVRQLAGWTANA-- 74
Query: 75 EESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQV 134
+ EI F ARV+LQD TGVP + D AAMR+ D+G DP I P+ P DLV+DHSVQV
Sbjct: 75 PRTAEIPFVVARVVLQDFTGVPLLCDLAAMRNVAADMGKDPKLIEPLVPVDLVVDHSVQV 134
Query: 135 DFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVF 194
D +P AL +N +LEF RN+ER+QF+KWG QAFD +VPPG GIVHQVNLEYL R V
Sbjct: 135 DHYGSPLALRQNMELEFQRNRERYQFMKWGMQAFDTFRVVPPGIGIVHQVNLEYLFRGVR 194
Query: 195 -----TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYK 249
G L +PD++VGTDSHTTMIN IEAEA MLGQ + +L P VVG +
Sbjct: 195 GHDTGDGMLYYPDTLVGTDSHTTMINGLGVVGWGVGGIEAEAGMLGQPVYLLTPDVVGVE 254
Query: 250 LVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGAT 309
L G LN T+TDLVLT+T+ LR VVGKFVEFFG G +L++ DRAT+ANM PE+GAT
Sbjct: 255 LKGRLNEGVTATDLVLTVTELLRRHKVVGKFVEFFGEGTASLTVTDRATLANMAPEYGAT 314
Query: 310 LAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDV 369
+ FP+D +++ Y+ T R + ++ E+Y RA + F E D +SE V LDL +
Sbjct: 315 MGFFPIDDKTVAYMRGTGRSDAECELFEAYFRAQQLFGVPQAGEID--YSETVTLDLASI 372
Query: 370 VTSVSGPKRPQDRVSVAIMKKDFQDCLTNKP 400
V S++GPKRPQDR+ ++ M +D D L ++P
Sbjct: 373 VPSLAGPKRPQDRIPLSDM-EDMFDRLFSRP 402
>UniRef50_Q4J9H0 Cluster: Aconitate hydratase; n=7; cellular
organisms|Rep: Aconitate hydratase - Sulfolobus
acidocaldarius
Length = 848
Score = 348 bits (855), Expect = 2e-94
Identities = 179/387 (46%), Positives = 252/387 (65%), Gaps = 22/387 (5%)
Query: 16 EINGSTYTYYDVSAL---GPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQ 72
+I S YY + L G D LP+S+++L+E+ RN DN ++ E+D+ + W++ +
Sbjct: 3 QILESNIRYYPIKQLKDRGYDVDSLPYSLKILVENTFRNLDNVKITEEDLDAIASWKTGK 62
Query: 73 GNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSV 132
E +F P RV+LQD TG+P +VD AAMRD + G DP +INPI +DL+IDHSV
Sbjct: 63 ------EFSFLPTRVVLQDYTGIPLLVDLAAMRDEMSKRGEDPLKINPIVQSDLIIDHSV 116
Query: 133 QVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARV 192
QVD+ T +L N+ EF RN ER++FLKW ++F N+ + PPG GI+HQ+NLEYL++V
Sbjct: 117 QVDYYGTASSLLLNKKKEFERNVERYKFLKWAQRSFKNLRVFPPGKGIIHQINLEYLSKV 176
Query: 193 V----FTGPL-LHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVG 247
V F G L +P+ V+GTDSHT M N +EAEAVMLG+ +M +P+VVG
Sbjct: 177 VDVKEFRGQLTAYPEIVIGTDSHTPMTNGLGVLSWGVGGLEAEAVMLGEPYTMAVPEVVG 236
Query: 248 YKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFG 307
+LVGE+ T TD+VL IT+ LR GVVGKFVEFFGP +G L++ DRAT+ANM PE+G
Sbjct: 237 VRLVGEIKEGVTPTDIVLYITEKLRKKGVVGKFVEFFGPSLGNLTVPDRATIANMAPEYG 296
Query: 308 ATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLG 367
AT ++FP+D ++L YL T R + ++E Y +A F E P +SEVV +DL
Sbjct: 297 ATASYFPIDYQTLNYLAATAR---EYKLVEKYAKAQGIFY-----ESQPKYSEVVTIDLS 348
Query: 368 DVVTSVSGPKRPQDRVSVAIMKKDFQD 394
+V +++GPK P +RV + +KK FQ+
Sbjct: 349 EVEPAIAGPKNPDERVPLKDLKKLFQE 375
>UniRef50_A5C294 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 885
Score = 342 bits (841), Expect = 9e-93
Identities = 205/424 (48%), Positives = 261/424 (61%), Gaps = 58/424 (13%)
Query: 1 MAGSTNPYQKLLKTIE--INGSTYTYYDVSALG-PKYDRLPFSIRVLLESCVRNCDNFQV 57
++ S+NP+ +LKT+E G YY + ALG P+ DRLP+SIR+LLES +RNCD FQV
Sbjct: 3 VSXSSNPFASILKTLEKPXGGEFGKYYSLPALGDPRIDRLPYSIRILLESAIRNCDEFQV 62
Query: 58 LEKDVSNVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDR 117
KDV ++DWE+ + + VEI FKPARV+LQ V V+D + D
Sbjct: 63 KAKDVEKIIDWEN--SSPKQVEIPFKPARVLLQ--VPVDLVIDHSVQVD----------- 107
Query: 118 INPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPG 177
+ ++ + ++ ++F R NKERF FLKWG+ AF NML+VPPG
Sbjct: 108 ---VAXSENAVQANMXLEFQR---------------NKERFGFLKWGSNAFHNMLVVPPG 149
Query: 178 SGIVHQVNLEYLARVVF-TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
SGIVHQVNLEYL RVVF T +L+PDSVVGTDSHTTMI+ IEAEA MLGQ
Sbjct: 150 SGIVHQVNLEYLGRVVFNTEGILYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQ 209
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+SM+LP VVG+KL G+L T+TDLVLT+T+ LR GVVGKFVEF+G G+ LS+ADR
Sbjct: 210 PMSMVLPGVVGFKLSGKLRDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMRELSLADR 269
Query: 297 ATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDP 356
AT+ANM PE+GAT+ FPVD +L+YL T R RD T P+ +
Sbjct: 270 ATIANMSPEYGATMGFFPVDHVTLQYLKLTGR------------------RDET-PQVEK 310
Query: 357 VFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKP--VPIAILSGVQEHVL 414
V+S +EL+L DV VSGPKRP DRV + MK D+ CL NK AI Q V+
Sbjct: 311 VYSSYLELNLEDVEPCVSGPKRPHDRVPLKEMKADWHSCLDNKVGFKGFAIPKESQSKVV 370
Query: 415 DFPY 418
+F Y
Sbjct: 371 EFSY 374
>UniRef50_Q97Z42 Cluster: Aconitate hydratase; n=3; cellular
organisms|Rep: Aconitate hydratase - Sulfolobus
solfataricus
Length = 855
Score = 329 bits (808), Expect = 9e-89
Identities = 172/379 (45%), Positives = 239/379 (63%), Gaps = 20/379 (5%)
Query: 19 GSTYTYYDVSAL---GPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGNE 75
GS YY + L G K LP+SIR+L+E+ RN D ++ E+D+ N+ W+ +
Sbjct: 9 GSEIYYYPLKELEEKGYKISDLPYSIRILIENVYRNLDGSKITEEDLENITKWKIGE--- 65
Query: 76 ESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVD 135
E+AF P RV++QD TGVP +VD AAMR+ + L DP INP+ PADLVIDHSVQVD
Sbjct: 66 ---ELAFMPTRVVMQDYTGVPLLVDLAAMREKMIQLKRDPKMINPVVPADLVIDHSVQVD 122
Query: 136 FARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFT 195
+ T +L N EF RN ER+QFLKW AF N+ IVPPG GI+HQVNLEYL+ VV
Sbjct: 123 YYGTVYSLEFNMKKEFERNLERYQFLKWAQGAFRNLRIVPPGKGIIHQVNLEYLSTVVAK 182
Query: 196 GPL-----LHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKL 250
+ P+ ++GTDSHTTMI +EAEAV+LG+ + +P+V+G +L
Sbjct: 183 AEVKGLLTAFPEVIIGTDSHTTMIEGLGILGWGVGGLEAEAVLLGEPYYLNVPEVIGVRL 242
Query: 251 VGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATL 310
GE+ T TD+VL IT+ LR VV KFVEFFGP + LS+ DRAT+ANM PE+GAT
Sbjct: 243 TGEIQEGVTPTDVVLYITELLRKKNVVSKFVEFFGPSLSLLSVPDRATIANMAPEYGATA 302
Query: 311 AHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVV 370
A+FP+D ++ YL TNR E ++ Y + + F D + + +S++VE+DL +
Sbjct: 303 AYFPIDDVTVSYLELTNRDGE---FVKKYAQLQELFYDDSRKIR---YSDIVEVDLSKIE 356
Query: 371 TSVSGPKRPQDRVSVAIMK 389
+++GP+ P +R+S+ +K
Sbjct: 357 PAIAGPRNPDERISLREVK 375
>UniRef50_Q125M5 Cluster: Aconitate hydratase-like; n=8;
Proteobacteria|Rep: Aconitate hydratase-like -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 888
Score = 306 bits (752), Expect = 6e-82
Identities = 163/371 (43%), Positives = 226/371 (60%), Gaps = 12/371 (3%)
Query: 17 INGSTYTYYDVSAL-GPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGNE 75
+NG + D+ AL G + RLP +R+LLE+ VRN + + V V W + G
Sbjct: 14 VNGQAHALVDLPALCGERLGRLPVVLRLLLENAVRNMQGDE-RQAAVDAVFAW-LEHGTS 71
Query: 76 ESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVD 135
E+ E+AF+P RV++ D T PA+VD AAMR+A+ + G DP +NP P D+ IDHS+ V+
Sbjct: 72 EA-ELAFQPGRVLMHDTTSTPALVDIAAMRNALDEAGVDPSVLNPGLPVDVSIDHSLAVE 130
Query: 136 FARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFT 195
DA+ N E RN ER++FL+W ++ + I PPG+GI+H +NLE LA VV T
Sbjct: 131 VYAQRDAVTLNLQHEIRRNGERYRFLRWASRVLSGVRIHPPGTGIMHTINLEQLATVVTT 190
Query: 196 ----GPLLH-PDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKL 250
G L PD ++GTDSHT MIN +EA+ VM G + +P V+G +L
Sbjct: 191 EERGGRLWAVPDMMIGTDSHTPMINGIGVLGWGVGGLEAQTVMFGMPTMLRIPDVIGVRL 250
Query: 251 VGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATL 310
G L P A STDL LT+T LR +GV G+FVEF+GPGV LS DR+ VANM PE+GAT
Sbjct: 251 TGRLPPAAQSTDLALTVTLRLRQIGVSGEFVEFYGPGVATLSAGDRSVVANMAPEYGATT 310
Query: 311 AHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVV 370
F VD R+L+YL T R ++ I ++E+Y R T + D PE +P ++ +E+DL +
Sbjct: 311 GFFAVDQRTLDYLRNTGRREDAIALVEAYTRRTGLWFD---PEAEPRYTRTIEIDLQTIG 367
Query: 371 TSVSGPKRPQD 381
V+GP+RPQD
Sbjct: 368 MHVAGPRRPQD 378
>UniRef50_P48200 Cluster: Iron-responsive element-binding protein 2;
n=45; Euteleostomi|Rep: Iron-responsive element-binding
protein 2 - Homo sapiens (Human)
Length = 963
Score = 305 bits (750), Expect = 1e-81
Identities = 144/261 (55%), Positives = 186/261 (71%), Gaps = 1/261 (0%)
Query: 140 PDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGP-L 198
P+ + KNQ++EF RN+ER QF KW ++ N+ ++PPG+G+ HQ+NLEYL+RVVF L
Sbjct: 211 PETVLKNQEVEFGRNRERLQFFKWSSRVLKNVAVIPPGTGMAHQINLEYLSRVVFEEKDL 270
Query: 199 LHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLA 258
L PDSVVGTDSH TM+N IE EAVMLG +S+ LP+VVG +L G NP
Sbjct: 271 LFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFV 330
Query: 259 TSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDAR 318
TS D+VL ITKHLR +GV GKFVEFFG GV LSI DR T+ANMCPE+GA L+ FPVD
Sbjct: 331 TSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNV 390
Query: 319 SLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKR 378
+L++L T K K++ +E+YL+A K FR+ N +P +S+V++++L +V SVSGPKR
Sbjct: 391 TLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKR 450
Query: 379 PQDRVSVAIMKKDFQDCLTNK 399
PQDRV+V MK DFQ CL K
Sbjct: 451 PQDRVAVTDMKSDFQACLNEK 471
Score = 169 bits (410), Expect = 2e-40
Identities = 75/131 (57%), Positives = 105/131 (80%), Gaps = 4/131 (3%)
Query: 8 YQKLLKTIEINGSTYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLD 67
++ L++T+ + S ++DVS LG KYD LP+SIRVLLE+ VRNCD F + ++DV N+LD
Sbjct: 10 FEYLIETLN-DSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILD 68
Query: 68 WESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLV 127
W++KQ N VE+ F PARV+LQD TG+PA+VDFAAMR+AVK LGGDP++++P CP DL
Sbjct: 69 WKTKQSN---VEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLT 125
Query: 128 IDHSVQVDFAR 138
+DHS+Q+DF++
Sbjct: 126 VDHSLQIDFSK 136
>UniRef50_Q7WB80 Cluster: Aconitate hydratase; n=3; Bordetella|Rep:
Aconitate hydratase - Bordetella parapertussis
Length = 894
Score = 304 bits (747), Expect = 2e-81
Identities = 164/389 (42%), Positives = 238/389 (61%), Gaps = 17/389 (4%)
Query: 19 GSTYTYYDVSAL----GPKYDRLPFSIRVLLESCVRNCDNFQ-VLEKDVSNVLDWESKQG 73
G+ Y DV+A G + LP+ IR+LLE+ +R+ + V E ++ V W++
Sbjct: 19 GTPIHYADVAAAAARSGVELASLPYVIRILLENLLRHRGRGRPVQEAEIEAVAHWQAHIS 78
Query: 74 NEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQ 133
+ S+ + RVIL D +G+P + D AA+RDAV+ GGDP R++ P DL++DHS+Q
Sbjct: 79 EQISLHVE----RVILPDSSGLPVLQDLAALRDAVQAGGGDPARVDTRVPVDLIVDHSLQ 134
Query: 134 VDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVV 193
VD T DA+ +N D EF RN++R++FLKW QAFD + + PG+GI+HQVNLE LA VV
Sbjct: 135 VDAWSTADAVRRNLDAEFARNEQRYRFLKWAQQAFDGLRVFAPGTGIIHQVNLEKLATVV 194
Query: 194 FTGP-----LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGY 248
T PD V+G DSHT M+N I+AE+ +LG+A + +P+VVG
Sbjct: 195 STSEHGGQQWACPDFVIGGDSHTPMVNGLGVLGWGVGGIDAESALLGRAYTFPIPEVVGV 254
Query: 249 KLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGA 308
+L G T+TD L +T+ LR+ GV G VEFFG + LS+ADRAT+ANM PE+GA
Sbjct: 255 ELKGAFRSPVTTTDAALLVTQRLRAEGVTGCMVEFFGEALPGLSVADRATIANMAPEYGA 314
Query: 309 TLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPV-FSEVVELDLG 367
T FPVDA++L+YL T R E I+++ +Y +A +R +P V ++ VV +DL
Sbjct: 315 TCGFFPVDAQTLDYLRLTGRTAEHIELVRAYCQANGLWR--ADPAASAVRYARVVRIDLA 372
Query: 368 DVVTSVSGPKRPQDRVSVAIMKKDFQDCL 396
+SGP+RPQDR+ + + +DF+ L
Sbjct: 373 QAEPCMSGPRRPQDRLPIGQLAEDFRQRL 401
>UniRef50_Q0ZQ48 Cluster: FrbA; n=6; cellular organisms|Rep: FrbA -
Streptomyces rubellomurinus
Length = 886
Score = 304 bits (747), Expect = 2e-81
Identities = 148/318 (46%), Positives = 209/318 (65%), Gaps = 3/318 (0%)
Query: 79 EIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFAR 138
E+ F+P R++LQD +G+P + D A++R + D G DP P P DLV+DHSV+V
Sbjct: 83 EVEFRPTRLVLQDHSGIPVLADLASLRSIMADRGLDPRLARPALPVDLVVDHSVEVASWA 142
Query: 139 TPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGP- 197
PDAL+ N E+ N ER++FL+W Q + +VPPG GIVHQ++LE+LARVV
Sbjct: 143 RPDALSLNMRREYELNGERYRFLRWAQQEISGLRVVPPGRGIVHQMHLEHLARVVLPDGD 202
Query: 198 -LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNP 256
L+ PD+V+GTDSHT M+ IEAE V+LG ++S+L P+V+G +L GEL
Sbjct: 203 GLIAPDTVLGTDSHTPMVGALGVLGWGVGGIEAETVLLGHSVSLLSPQVIGVRLTGELPV 262
Query: 257 LATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVD 316
+T+TDL LT+T+ LR++GVVG+FVEFFGPGV ALS+ DRAT++NM PE+G T+A FPVD
Sbjct: 263 GSTATDLALTMTEFLRNVGVVGRFVEFFGPGVCALSVPDRATLSNMAPEYGCTVAFFPVD 322
Query: 317 ARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGP 376
+L YL T R E+I ++E+Y + F + DP F+ V++ DL V S +GP
Sbjct: 323 DTTLRYLELTGRGAEEIRLVEAYCKEQGLFAG-ADASADPEFARVLDFDLSAVEPSAAGP 381
Query: 377 KRPQDRVSVAIMKKDFQD 394
+RPQDR+ + + F +
Sbjct: 382 RRPQDRLPLGTVPASFPE 399
>UniRef50_A5WEQ7 Cluster: 2-methylisocitrate dehydratase,
Fe/S-dependent; n=155; cellular organisms|Rep:
2-methylisocitrate dehydratase, Fe/S-dependent -
Psychrobacter sp. PRwf-1
Length = 903
Score = 284 bits (697), Expect = 3e-75
Identities = 149/367 (40%), Positives = 226/367 (61%), Gaps = 19/367 (5%)
Query: 27 VSALGP-KYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGNEESVEIAFKPA 85
V+A+ P Y +LPFS +VL E+ VR C +D++ L + ++ ++ + PA
Sbjct: 48 VNAIEPGAYAKLPFSSKVLCENLVRRCP-----PEDLTEALSQHIYR--KQDIDFPWYPA 100
Query: 86 RVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFARTPD-ALN 144
RV+ D+ G A VD A +RDA+ GGDP ++NPI P L++DHS+ V+ A + A
Sbjct: 101 RVVCHDILGQTAFVDLAGLRDAIAAEGGDPAKVNPIVPTQLIVDHSLAVEHAGYEENAFE 160
Query: 145 KNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFT-------GP 197
KN+ +E RN++RF F+ W AFDN+ +VPPG+GI+HQ+NLE ++ VV P
Sbjct: 161 KNRAIEERRNEDRFHFINWCEYAFDNVNVVPPGNGIMHQINLEKMSPVVQVITDKNDGTP 220
Query: 198 LLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPL 257
+ +PD++VGTDSHT M++ +EAE+VMLG M LP ++G +L G+L P
Sbjct: 221 VAYPDTLVGTDSHTPMVDALGVISIGVGGLEAESVMLGNPSYMRLPDIIGLELTGKLQPG 280
Query: 258 ATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDA 317
T TDLVL +T+ LR GVV +VE FG G +LS+ DRA+++NM PE+GAT F +D
Sbjct: 281 ITGTDLVLAMTEFLRDEGVVSAYVECFGDGARSLSVGDRASISNMTPEYGATAVMFYIDE 340
Query: 318 RSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPK 377
++++YL T R +++I+V+E+Y + T + D Q + V+ DL VV +++GP
Sbjct: 341 QTIDYLRLTGRTEKQINVVEAYAKHTGLWAD---GMQQAKYERVLRFDLSKVVRNIAGPS 397
Query: 378 RPQDRVS 384
+P RVS
Sbjct: 398 KPHARVS 404
>UniRef50_A3BB05 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 696
Score = 260 bits (636), Expect = 6e-68
Identities = 147/296 (49%), Positives = 184/296 (62%), Gaps = 24/296 (8%)
Query: 148 DLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGP-LLHPDSVVG 206
+LEF RNKERF FLKW + AF M + PPGSGIVHQVNLEYLARVVF +++PDSVVG
Sbjct: 2 ELEFDRNKERFGFLKWASTAFHKMQVFPPGSGIVHQVNLEYLARVVFNADGIMYPDSVVG 61
Query: 207 TDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLT 266
TDSHTTMIN IEA MLGQ + M+LP VVG+KL G L T+TDLVLT
Sbjct: 62 TDSHTTMINSLGVAGWGVGGIEAIVAMLGQPMDMVLPGVVGFKLSGMLRDGVTATDLVLT 121
Query: 267 ITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVD----ARSLEY 322
IT+ LR GVVGKFVEF+G GVG LS+ RAT+ANM PE+GA++ FPVD R +
Sbjct: 122 ITQMLRKHGVVGKFVEFYGVGVGELSLPARATIANMSPEYGASMGFFPVDHYNYLRKISS 181
Query: 323 LH-----QTN------------RPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELD 365
H Q N +K+ +IE+YLRA F ++ P + V+S +EL+
Sbjct: 182 FHTRLIKQHNLAITCTYDITRCMHNKKVSMIEAYLRANNMFVEHHEPHTERVYSSYLELN 241
Query: 366 LGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNKP--VPIAILSGVQEHVLDFPYQ 419
L DV +SGPKRP DRV + MK D+ CL ++ A+ Q+ V+ F +Q
Sbjct: 242 LIDVEPCISGPKRPHDRVPLKEMKSDWHACLDSRVGFKGFAVPRECQDKVVKFDFQ 297
>UniRef50_Q4YCZ3 Cluster: Putative uncharacterized protein; n=1;
Plasmodium berghei|Rep: Putative uncharacterized protein
- Plasmodium berghei
Length = 269
Score = 222 bits (543), Expect = 1e-56
Identities = 107/192 (55%), Positives = 137/192 (71%), Gaps = 5/192 (2%)
Query: 4 STNPYQKLLKTIEINGSTYTYYDVSALGP-KYDRLPFSIRVLLESCVRNCDNFQVLEKDV 62
S NP++ L K + N Y YYD++ L + LP+SIR+LLES +RNCDN +V E++V
Sbjct: 19 SNNPFENLRK--KFNKGNYHYYDLNELNDSRIKSLPYSIRILLESAIRNCDNLKVTEENV 76
Query: 63 SNVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPIC 122
+L W K+ ++ EI F P RV+LQDLTGVP VVD A MRD + LGGD ++INP+
Sbjct: 77 KTILAW--KENCKKKKEIPFMPTRVLLQDLTGVPCVVDLATMRDTAEFLGGDANKINPLI 134
Query: 123 PADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVH 182
P DLVIDHSVQVD++R+ A N+ EF RN ERF+FLKWG +F+NMLI+PPGS IVH
Sbjct: 135 PVDLVIDHSVQVDYSRSSKAKEYNEKREFERNLERFKFLKWGMNSFENMLILPPGSRIVH 194
Query: 183 QVNLEYLARVVF 194
Q+NLEYLA VF
Sbjct: 195 QINLEYLAHCVF 206
>UniRef50_A4FHT3 Cluster: Aconitate hydratase 1; n=2;
Actinomycetales|Rep: Aconitate hydratase 1 -
Saccharopolyspora erythraea (strain NRRL 23338)
Length = 711
Score = 148 bits (359), Expect = 2e-34
Identities = 80/191 (41%), Positives = 111/191 (58%), Gaps = 2/191 (1%)
Query: 203 SVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTD 262
S TDSHT M+N ++A+A M+G+ ++ P VVG +L G L T+TD
Sbjct: 27 SETATDSHTPMVNSIGVLGWGVGGLQAQAAMVGEPTAIRFPTVVGVRLTGRLRSGVTATD 86
Query: 263 LVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
L LT+T+ LR+ GVV KFVEF GPG L A RA V+NM PE+GAT A FP D ++ Y
Sbjct: 87 LALTVTELLRAHGVVDKFVEFTGPGATGLGWAARAAVSNMAPEYGATCAFFPFDDEAMSY 146
Query: 323 LHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDR 382
L T R E+ V+ +YLRA +R +P P + E V LDL + S++GP P R
Sbjct: 147 LELTARSPEQRAVVAAYLRAQGLYRRAGDPV--PRYDEEVALDLDAIEPSLAGPHLPHQR 204
Query: 383 VSVAIMKKDFQ 393
V+++ + F+
Sbjct: 205 VALSRVPHSFR 215
>UniRef50_Q3YMK8 Cluster: Iron regulatory protein 2; n=5;
Clupeocephala|Rep: Iron regulatory protein 2 - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 246
Score = 137 bits (332), Expect = 4e-31
Identities = 63/135 (46%), Positives = 91/135 (67%), Gaps = 5/135 (3%)
Query: 6 NPYQKLLKTIEING-STYTYYDVSALGP-KYDRLPFSIRVLLESCVRNCDNFQVLEKDVS 63
+PY L+ T++ Y+ L +Y++LPF +RVLLES +R CD F V +DVS
Sbjct: 10 HPYGHLIDTLQSEQYQERRYFSPQKLNDVRYEKLPFCMRVLLESAIRKCDEFYVKTEDVS 69
Query: 64 NVLDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICP 123
++LDW+ +Q E+ F PARV+LQD TG+PA+VD AAMRDA+ G DP +NP CP
Sbjct: 70 SILDWQVQQNQ---AEVVFSPARVLLQDFTGIPAMVDLAAMRDALAKQGVDPSLVNPRCP 126
Query: 124 ADLVIDHSVQVDFAR 138
DL++DHS+Q+D+++
Sbjct: 127 TDLIVDHSLQIDYSK 141
Score = 38.7 bits (86), Expect = 0.28
Identities = 13/24 (54%), Positives = 19/24 (79%)
Query: 140 PDALNKNQDLEFVRNKERFQFLKW 163
P+ + +NQ++E +RNKER QF KW
Sbjct: 221 PETMVRNQEMELIRNKERLQFFKW 244
>UniRef50_P19414 Cluster: Aconitate hydratase, mitochondrial
precursor; n=41; cellular organisms|Rep: Aconitate
hydratase, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 778
Score = 129 bits (311), Expect = 2e-28
Identities = 107/337 (31%), Positives = 151/337 (44%), Gaps = 33/337 (9%)
Query: 55 FQVLEKDVSNVLDWESKQGNEESVE-IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGG 113
F EK + LD Q + V + +P RV QD T A++ F + G
Sbjct: 59 FTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMS--------AG 110
Query: 114 DPDRINPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLI 173
P P+ + DH +Q D L + DL NKE + FL A A NM
Sbjct: 111 LPQVAKPVT---VHCDHLIQAQVGGEKD-LKRAIDL----NKEVYDFLA-SATAKYNMGF 161
Query: 174 VPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVM 233
PGSGI+HQ+ LE A F G L ++GTDSHT +A VM
Sbjct: 162 WKPGSGIIHQIVLENYA---FPGAL-----IIGTDSHTPNAGGLGQLAIGVGGADAVDVM 213
Query: 234 LGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSI 293
G+ + PK++G KL G++N + D++L + G GK VE+FG GV S
Sbjct: 214 AGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSA 273
Query: 294 ADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPE 353
T+ NM E GAT + FP + +EYL T R K I + A +D + +
Sbjct: 274 TGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGK-----IADF--AKLYHKDLLSAD 326
Query: 354 QDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKK 390
+D + EVVE+DL + ++GP P V+ MK+
Sbjct: 327 KDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKE 363
>UniRef50_UPI00015B4325 Cluster: PREDICTED: similar to aconitase,
mitochondrial; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to aconitase, mitochondrial - Nasonia
vitripennis
Length = 917
Score = 121 bits (292), Expect = 3e-26
Identities = 109/357 (30%), Positives = 163/357 (45%), Gaps = 39/357 (10%)
Query: 25 YDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDWESKQGNEESVE-IAFK 83
+D +A P YD+L +I+++ + R + EK + + LD KQ + +
Sbjct: 171 FDSTAYLP-YDKLDENIKIVKKRLDRP---LTLSEKILYSHLDEPQKQDIVRGTSYLRLR 226
Query: 84 PARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFARTPDAL 143
P RV +QD T A++ F + G P R+ P+ + DH ++ D L
Sbjct: 227 PDRVAMQDATAQMAMLQFIS--------SGLP-RV--AVPSTIHCDHLIEAQLGGDKD-L 274
Query: 144 NKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDS 203
+ +D+ NKE + FLK + + PGSGI+HQ+ LE A F G L+
Sbjct: 275 KRAKDI----NKEVYSFLKTAGAKY-GVGFWNPGSGIIHQIILENYA---FPGLLM---- 322
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
+GTDSHT +A VM + PKV+G KL GEL + D+
Sbjct: 323 -IGTDSHTPNGGGLGGLCIGVGGADAVDVMANIPWELKCPKVIGVKLTGELKGWTSPKDI 381
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + L G G VE+FGPGV ++S AT+ NM E GAT + FP + R +YL
Sbjct: 382 ILKVAGILTVKGGTGAIVEYFGPGVDSISCTGMATICNMGAEIGATTSVFPYNDRMKDYL 441
Query: 324 HQTNRPKEKIDVIESYLRATKQFR-DYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
T R S A QF+ + + + +V+ELDL + V+GP P
Sbjct: 442 KATQR--------ASIASAADQFKGSLLTADSNAKYDQVIELDLSTLEPHVNGPFTP 490
>UniRef50_O13966 Cluster: Aconitate hydratase, mitochondrial
precursor; n=21; cellular organisms|Rep: Aconitate
hydratase, mitochondrial precursor - Schizosaccharomyces
pombe (Fission yeast)
Length = 778
Score = 120 bits (288), Expect = 9e-26
Identities = 100/333 (30%), Positives = 147/333 (44%), Gaps = 34/333 (10%)
Query: 59 EKDVSNVLDWESKQGNEESVE-IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDR 117
EK + LD Q E V + +P RV QD T A++ F + G P+
Sbjct: 63 EKILYGHLDDPVNQDIERGVSYLKLRPDRVACQDATAQMAILQFMS--------AGMPEV 114
Query: 118 INPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPG 177
P+ + DH ++ D N V NKE + FL+ + N+ PG
Sbjct: 115 AVPVT---VHCDHLIEAYEGGPIDLERAN-----VTNKEVYDFLQTACAKY-NIGFWRPG 165
Query: 178 SGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQA 237
SGI+HQ+ LE A F G LL +GTDSHT +A VM
Sbjct: 166 SGIIHQIVLENYA---FPGGLL-----IGTDSHTPNAGGLGMVAIGVGGADAVDVMANLP 217
Query: 238 ISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRA 297
+ PKV+G KL G+L + D++L + L G G VE+FGPGV +LS
Sbjct: 218 WELKCPKVIGVKLTGQLKGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVESLSCTGMG 277
Query: 298 TVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPV 357
T+ NM E GAT + FP + R EYL TNR I Y ++F +++
Sbjct: 278 TICNMGAEIGATTSIFPFNPRMSEYLRATNR-----SAIADY---AEEFAPIIAADENAH 329
Query: 358 FSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKK 390
+ +++E+DL + ++GP P ++ K+
Sbjct: 330 YDQIIEIDLNTLEPHLNGPFTPDLATPISKFKE 362
>UniRef50_Q0VKG5 Cluster: Aconitate hydratase; n=2; Bacteria|Rep:
Aconitate hydratase - Pseudomonas fluorescens
Length = 149
Score = 116 bits (279), Expect = 1e-24
Identities = 56/122 (45%), Positives = 82/122 (67%)
Query: 227 IEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGP 286
+EAE+VMLG+A M LP+ VG +L G+L P T+TD+VL +T+ LR VVG ++EFF
Sbjct: 12 LEAESVMLGRASWMRLPESVGVELTGKLQPGITATDMVLALTEFLRQQKVVGAWLEFFXE 71
Query: 287 GVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQF 346
G AL++ DRAT++NM PE+GAT F +DA+++ YL T R ++ ++E R T +
Sbjct: 72 GASALTLGDRATISNMAPEYGATAXMFYIDAQTIAYLKLTGREDXQVXLVEQXARHTXLW 131
Query: 347 RD 348
D
Sbjct: 132 AD 133
>UniRef50_Q99798 Cluster: Aconitate hydratase, mitochondrial
precursor; n=28; cellular organisms|Rep: Aconitate
hydratase, mitochondrial precursor - Homo sapiens
(Human)
Length = 780
Score = 113 bits (271), Expect = 1e-23
Identities = 92/322 (28%), Positives = 147/322 (45%), Gaps = 34/322 (10%)
Query: 59 EKDVSNVLDWESKQGNEESVE-IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDR 117
EK V LD + Q E + +P RV +QD T A++ F + +
Sbjct: 67 EKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF---------ISSGLSK 117
Query: 118 INPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPG 177
+ P+ + DH ++ D L + +D+ N+E + FL + + PG
Sbjct: 118 V--AVPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAGAKY-GVGFWKPG 169
Query: 178 SGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQA 237
SGI+HQ+ LE A + G LL +GTDSHT +A VM G
Sbjct: 170 SGIIHQIILENYA---YPGVLL-----IGTDSHTPNGGGLGGICIGVGGADAVDVMAGIP 221
Query: 238 ISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRA 297
+ PKV+G KL G L+ ++ D++L + L G G VE+ GPGV ++S A
Sbjct: 222 WELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMA 281
Query: 298 TVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPV 357
T+ NM E GAT + FP + R +YL +T R E +F+D+ P+
Sbjct: 282 TICNMGAEIGATTSVFPYNHRMKKYLSKTGR--------EDIANLADEFKDHLVPDPGCH 333
Query: 358 FSEVVELDLGDVVTSVSGPKRP 379
+ +++E++L ++ ++GP P
Sbjct: 334 YDQLIEINLSELKPHINGPFTP 355
>UniRef50_Q0CSK9 Cluster: Aconitate hydratase, mitochondrial; n=2;
Pezizomycotina|Rep: Aconitate hydratase, mitochondrial -
Aspergillus terreus (strain NIH 2624)
Length = 781
Score = 111 bits (267), Expect = 3e-23
Identities = 86/271 (31%), Positives = 120/271 (44%), Gaps = 26/271 (9%)
Query: 59 EKDVSNVLDWESKQGNEESVE-IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDR 117
EK + + LD Q E V + +P RV QD T A++ F + G P
Sbjct: 97 EKVLYSHLDDPHGQDIERGVSYLKLRPDRVACQDATAQMAILQFMS--------AGMP-- 146
Query: 118 INPICPADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPG 177
+ P + DH ++ D N+ NKE + FL + N+ PG
Sbjct: 147 -SVATPTTVHCDHLIEAQVGGEKDLARANEI-----NKEVYDFLATATAKY-NIGFWKPG 199
Query: 178 SGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQA 237
SGI+HQ+ LE A F G L+ +GTDSHT +A VM G
Sbjct: 200 SGIIHQIVLENYA---FPGGLM-----IGTDSHTPNAGGLAMAAIGVGGADAVDVMAGLP 251
Query: 238 ISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRA 297
+ PKV+G KL GE++ T D++L + L G G +E+ GPGV +LS
Sbjct: 252 WELKAPKVIGVKLTGEMSGWTTPKDIILKVAGLLTVKGGTGAIIEYHGPGVNSLSCTGMG 311
Query: 298 TVANMCPEFGATLAHFPVDARSLEYLHQTNR 328
T+ NM E GAT + FP + R +YL T R
Sbjct: 312 TICNMGAEIGATTSMFPFNDRMYDYLKATKR 342
>UniRef50_Q74AD1 Cluster: Aconitate hydratase, putative; n=12;
Bacteria|Rep: Aconitate hydratase, putative - Geobacter
sulfurreducens
Length = 645
Score = 111 bits (266), Expect = 4e-23
Identities = 95/308 (30%), Positives = 139/308 (45%), Gaps = 49/308 (15%)
Query: 79 EIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFAR 138
EIA K +LQD TG A+++F AM DR+ A + + +Q D
Sbjct: 24 EIALKIDHALLQDATGTMAMLEFIAM---------GVDRVKVELAAQYIDHNLLQTD--- 71
Query: 139 TPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPL 198
N+N D + V FL AQ F + + PG+G+ HQV+LE R G
Sbjct: 72 -----NRNAD-DHV-------FLMTAAQRF-GVHLSKPGNGVSHQVHLE---RFGVPGR- 113
Query: 199 LHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLA 258
+++G DSHTT ++ M G + PK+ G KL G+L P
Sbjct: 114 ----TMLGADSHTTSAAGLSMIAIGAGGLDVSLAMAGHPFHLPCPKIWGVKLTGQLQPWV 169
Query: 259 TSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDAR 318
++ D++L + + G VGK +E++GPGV LS DRA + NM E GAT + FP D R
Sbjct: 170 SAKDVILEMLRRHTVKGGVGKIIEYYGPGVATLSATDRAIIGNMGAELGATTSLFPSDHR 229
Query: 319 SLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKR 378
+ E+L R + + L A + D + E E+DL V ++ P
Sbjct: 230 TREFLEAQGRGE-----VWQELAA----------DPDATYDEYEEIDLATVEPLIACPSS 274
Query: 379 PQDRVSVA 386
P + V VA
Sbjct: 275 PDNVVRVA 282
>UniRef50_O67656 Cluster: Aconitase; n=17; cellular organisms|Rep:
Aconitase - Aquifex aeolicus
Length = 659
Score = 110 bits (265), Expect = 6e-23
Identities = 89/312 (28%), Positives = 146/312 (46%), Gaps = 51/312 (16%)
Query: 75 EESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSV-Q 133
E EIA K + + QD TG ++F AM G P+ + + IDH++ Q
Sbjct: 21 EPGEEIAIKIDQTLTQDATGTMCYLEFEAM--------GVPEVKTELSVS--YIDHNMLQ 70
Query: 134 VDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVV 193
DF RN + ++L A+ F + + PG+GI HQV+LE A+
Sbjct: 71 TDF----------------RNADDHKYLMSVAKKF-GIWLSKPGNGICHQVHLERFAKPG 113
Query: 194 FTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGE 253
T ++G+DSHT ++ A M G+ + +PK+VG L G+
Sbjct: 114 KT--------LLGSDSHTPTAGGMGMLAIGAGGLDVAAAMAGEPFYLKMPKIVGVHLKGK 165
Query: 254 LNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHF 313
+ T+ D++L + + L G +GK E+FG GV LS+ +RAT+ NM E GAT + F
Sbjct: 166 MPEWVTAKDIILELLRRLTVKGGLGKIFEYFGEGVKELSVPERATITNMGAELGATTSIF 225
Query: 314 PVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSV 373
P D + YL R ++ ++++ P+ D + EV+E++L ++ +
Sbjct: 226 PSDEITRAYLRAQGREEDWVELL---------------PDPDAEYDEVIEINLSELEPLI 270
Query: 374 SGPKRPQDRVSV 385
+ P P + V V
Sbjct: 271 AQPHSPDNVVPV 282
>UniRef50_Q0USA6 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 781
Score = 108 bits (260), Expect = 2e-22
Identities = 93/340 (27%), Positives = 157/340 (46%), Gaps = 31/340 (9%)
Query: 80 IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFART 139
+ KP RV +QD + A++ F + LG PA + DH + + +
Sbjct: 105 LKLKPDRVAMQDASAQMALLQFMSC-----GLG------KTAVPASIHCDHMIVGE--KG 151
Query: 140 PDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLL 199
D L+ Q ++ NKE F FL+ A+ + + PPG+GI+HQ LE ++ P L
Sbjct: 152 AD-LDLPQSIK--GNKEVFDFLESAAKKY-GIEFWPPGAGIIHQSVLEN-----YSAPGL 202
Query: 200 HPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLAT 259
++GTDSH+ +A ++ + PK++G KL GEL+ A+
Sbjct: 203 ---MMLGTDSHSPNAGGLGAIVIGVGGADAVDALVDAPWELKAPKILGVKLTGELSGWAS 259
Query: 260 STDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARS 319
D++L++ L G G +E+FGPGV LS AT+ NM E GAT + FP
Sbjct: 260 PKDVILSLAGQLTVRGGTGYIIEYFGPGVQTLSCTGMATICNMGAEVGATTSLFPFSPAH 319
Query: 320 LEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
+ YL T+R I + + ++ P+ + + +V+E++L ++ ++GP P
Sbjct: 320 VPYLQATHR--GPIAEQAGKIANSPMQQNLLRPDPEAAYDKVIEINLSELEPHINGPFTP 377
Query: 380 QDRVSVAIMKKDFQDCLTNKPVPIAILSGVQEHVLDFPYQ 419
+S + K F+ + K P +G+ + YQ
Sbjct: 378 D--LSTPLSK--FKSLVEEKDWPKTFGAGLIGSCTNSSYQ 413
>UniRef50_A0RTP9 Cluster: 3-isopropylmalate isomerase/aconitase A;
n=7; cellular organisms|Rep: 3-isopropylmalate
isomerase/aconitase A - Cenarchaeum symbiosum
Length = 754
Score = 104 bits (250), Expect = 4e-21
Identities = 87/296 (29%), Positives = 127/296 (42%), Gaps = 27/296 (9%)
Query: 84 PARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFARTPDAL 143
P RV LQD+TG ++ F R L P + DH ++ A+
Sbjct: 62 PDRVALQDVTGQMVMLQFMVTRHEETAL-----------PTTIHCDHLIR---AKVEGGE 107
Query: 144 NKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDS 203
+ L+ N E F+FLK A + PG+GI+HQV LE A F G L+
Sbjct: 108 DMRVSLD--ENSEVFRFLKSAAARY-GCGFWKPGAGIIHQVVLENYA---FPGGLM---- 157
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
+GTDSHT ++A M + +L PK +G L G+ + + D+
Sbjct: 158 -IGTDSHTPNAGGLGMIAVGVGGMDAAEAMAIKEWELLYPKRIGVHLTGKSSGWTSPKDV 216
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + + L G VE+ GPG +S +AT+ NM E GAT + FP D R EYL
Sbjct: 217 ILKVVEELTVSGGTNAIVEYLGPGASTISCTGKATITNMGAEMGATCSIFPYDNRMGEYL 276
Query: 324 HQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
T R I + + R + +S V+E+DL + + GP P
Sbjct: 277 GYTGRC--GITKLANLHRELLVADPEIEEDPSKYYSRVIEIDLSRLEPHIVGPHTP 330
>UniRef50_Q5V0F1 Cluster: Aconitate hydratase; n=8; cellular
organisms|Rep: Aconitate hydratase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 677
Score = 101 bits (242), Expect = 4e-20
Identities = 70/234 (29%), Positives = 114/234 (48%), Gaps = 24/234 (10%)
Query: 153 RNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTT 212
+N + +FL+ A F PG+GI H V+ E F P +++G+DSHT
Sbjct: 93 KNTDDHRFLRSAAGTF-GAHFSRPGNGICHNVHKEN-----FAAP---GKTMLGSDSHTP 143
Query: 213 MINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLR 272
++ M G A + +P+VV +L GEL AT+ D++L + + L
Sbjct: 144 TPGGLGELAIGSGGLDVAVAMGGGAYYIEMPEVVNVRLEGELPEWATAKDVILELLRRLS 203
Query: 273 SLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEK 332
G VGK +E+ GPGV L++ +R T+ NM E GAT + FP D ++ +YL + R
Sbjct: 204 VKGGVGKVLEYTGPGVETLTVPERTTITNMGTELGATSSIFPTDDQTKDYLERLGRE--- 260
Query: 333 IDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVA 386
DV E P++D +++ + +DL D+ ++ P P + V V+
Sbjct: 261 -DVFED-----------IGPDEDAEYADEIVVDLSDLEPLIAEPSMPDNVVPVS 302
>UniRef50_Q4PB22 Cluster: Putative uncharacterized protein; n=5;
Fungi/Metazoa group|Rep: Putative uncharacterized
protein - Ustilago maydis (Smut fungus)
Length = 1041
Score = 98.3 bits (234), Expect = 3e-19
Identities = 77/257 (29%), Positives = 119/257 (46%), Gaps = 20/257 (7%)
Query: 123 PADLVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVH 182
P+ + DH +Q F L ++ N+E F FL+ ++ + + PGSGI+H
Sbjct: 237 PSSVHCDHLIQA-FEGAEADLKRS----IASNQEVFAFLESASKKY-GIEFWGPGSGIIH 290
Query: 183 QVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLL 242
Q+ LE A G L+ +GTDSHT + +A M ++
Sbjct: 291 QIVLENYAA---PGLLM-----LGTDSHTPNASGLGCLAIGVGGADAVDAMTNTPWELMA 342
Query: 243 PKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANM 302
PKV+G L GEL+P T D++L + L G GK VE+ GPG+ L AT++NM
Sbjct: 343 PKVLGVHLKGELSPWCTPKDVILHLAGKLTVRGGTGKIVEYSGPGLQTLPATGLATMSNM 402
Query: 303 CPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVV 362
E GAT + FP YL T R +V + +A Q + ++ + E +
Sbjct: 403 GAEVGATTSAFPFTPAMGSYLEATGR----AEVARAAEKAAGQ--GFLAADEGAEYDERI 456
Query: 363 ELDLGDVVTSVSGPKRP 379
E++L D+ ++GP P
Sbjct: 457 EINLSDLEPCLNGPFTP 473
>UniRef50_Q9VIE8 Cluster: CG9244-PB; n=37; cellular organisms|Rep:
CG9244-PB - Drosophila melanogaster (Fruit fly)
Length = 787
Score = 97.9 bits (233), Expect = 4e-19
Identities = 85/300 (28%), Positives = 135/300 (45%), Gaps = 32/300 (10%)
Query: 80 IAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFART 139
+ +P RV +QD T A++ F + +K + P+ + DH ++
Sbjct: 96 LRLRPDRVAMQDATAQMALLQFIS--SGLKKVA---------VPSTVHCDHLIEAQIGGP 144
Query: 140 PDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLL 199
D L + +DL NKE + FL + + PGSGI+HQ+ LE A F G L+
Sbjct: 145 KD-LARAKDL----NKEVYDFLASTCAKY-GLGFWKPGSGIIHQIILENYA---FPGLLM 195
Query: 200 HPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLAT 259
+GTDSHT +A VM + PKV+G L G+++ +
Sbjct: 196 -----IGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTS 250
Query: 260 STDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARS 319
D++L + L G G +E+ G GV ++S AT+ NM E GAT + FP + R
Sbjct: 251 PKDVILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRM 310
Query: 320 LEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
+YL T R I S A K + +++ + E++E++L + V+GP P
Sbjct: 311 ADYLKSTGRAG-----IAS--EAQKYQAKILSADKNCEYDELIEINLDTLEPHVNGPFTP 363
>UniRef50_Q7NDZ5 Cluster: Aconitate hydratase; n=28; Bacteria|Rep:
Aconitate hydratase - Gloeobacter violaceus
Length = 645
Score = 95.1 bits (226), Expect = 3e-18
Identities = 64/232 (27%), Positives = 108/232 (46%), Gaps = 24/232 (10%)
Query: 154 NKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTM 213
N + ++L+ Q + ++ PG+GI HQV+ E A + +++G+DSHT
Sbjct: 72 NADDHRYLQSVGQKY-GIVFSRPGNGICHQVHRERFA--------VPAQTLLGSDSHTPT 122
Query: 214 INXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRS 273
++ M G+ + +PKV+G +L G L P + D++L + + L
Sbjct: 123 CGGLGMLAIGAGGLDVAVAMAGEPYFIPMPKVLGVRLTGTLQPWCSGKDVILEMLRRLTV 182
Query: 274 LGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKI 333
G G+ VE+ GPGV +LS++ R T+ NM E GAT + FP D + +L R + +
Sbjct: 183 KGGTGRIVEYTGPGVASLSVSHRFTITNMGAELGATTSVFPSDEVTHRFLAAQGREGDWV 242
Query: 334 DVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSV 385
+ + D + E VE+DL + + P P + VSV
Sbjct: 243 PLA---------------ADPDATYDETVEIDLDTLEPLTACPSSPDNVVSV 279
>UniRef50_Q2UTF0 Cluster: Aconitase/homoaconitase; n=9; cellular
organisms|Rep: Aconitase/homoaconitase - Aspergillus
oryzae
Length = 806
Score = 93.5 bits (222), Expect = 9e-18
Identities = 77/312 (24%), Positives = 128/312 (41%), Gaps = 30/312 (9%)
Query: 68 WESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLV 127
W ++ + + +P RV D T A++ F + G P R+ P +
Sbjct: 86 WSLQEIDRGKTILELRPDRVACHDATATMALLQFIS--------AGLP-RV--AVPTTVH 134
Query: 128 IDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLE 187
DH + + PD + E ++FL ++ + + PGSGI+H V
Sbjct: 135 GDHLIVSEKGAEPDMKRA-----LTEHAEVYEFLSSASRKY-GIGFWKPGSGIIHTV--- 185
Query: 188 YLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVG 247
+F + ++GTDSHT +A M G ++ P++VG
Sbjct: 186 -----IFENHAVPGGLIIGTDSHTPNAGGLAMMGIGVGGSDAVDAMSGMPWELVTPQIVG 240
Query: 248 YKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFG 307
+L G+L+ A++ D++ + L G G+ +EFFGPG L AT+ NM E G
Sbjct: 241 VRLTGQLSGWASTKDIICKLAGILTVSGGKGRVIEFFGPGTETLGATAMATICNMSAEIG 300
Query: 308 ATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLG 367
+T FP YL T R + + +Q + D + +V+E+DL
Sbjct: 301 STSCIFPYTTAMGRYLTATRRAH-----VAQAAQGVQQALLQADEGSDKYYDQVIEIDLS 355
Query: 368 DVVTSVSGPKRP 379
+ V+GP P
Sbjct: 356 TLEPHVNGPYTP 367
>UniRef50_Q1IMD4 Cluster: Aconitate hydratase-like; n=1;
Acidobacteria bacterium Ellin345|Rep: Aconitate
hydratase-like - Acidobacteria bacterium (strain
Ellin345)
Length = 655
Score = 89.0 bits (211), Expect = 2e-16
Identities = 63/216 (29%), Positives = 99/216 (45%), Gaps = 10/216 (4%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G+GI HQ+ +E G ++ VV +DSH+ M +A A+
Sbjct: 99 GTGIGHQIMVE-------RGYVVPESFVVASDSHSNMYGAMGAIGTPVVRTDAAAIWATG 151
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+P+ + L G+L P T D+++T+ V+ +EF G GV L++ +R
Sbjct: 152 EFWWSIPRTIQVVLEGKLRPGVTGKDVIITLAGLYNKDEVLNAALEFAGSGVHTLTMDER 211
Query: 297 ATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYL--RATKQFRDYTNPEQ 354
++ANM E+GA FPVD ++ YL Q + E + K R P++
Sbjct: 212 LSIANMSTEWGALTGWFPVDQVTISYLRQ-RHGVARWQGTEKFTEEELLKWARAPLGPDK 270
Query: 355 DPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKK 390
D ++ +ELDL V VSGP Q SVA M++
Sbjct: 271 DATYAAKIELDLAQVTPHVSGPDSVQVMHSVAQMEE 306
>UniRef50_A4W1Y9 Cluster: Aconitase A; n=1; Streptococcus suis
98HAH33|Rep: Aconitase A - Streptococcus suis (strain
98HAH33)
Length = 129
Score = 89.0 bits (211), Expect = 2e-16
Identities = 50/112 (44%), Positives = 67/112 (59%), Gaps = 7/112 (6%)
Query: 13 KTIEINGSTYTYYDVSALG--PKYD--RLPFSIRVLLESCVRNCDNFQVLEKDVSNVLDW 68
K + G Y+YY + ++ K D LP++IR+LLES +R D V + + +L +
Sbjct: 7 KRLFYKGEEYSYYALESISMEEKVDIHSLPYTIRILLESLLRKEDGVDVTKNHIMELLHY 66
Query: 69 ESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINP 120
Q EI FKP+RVILQD TGVP VVD A+MRDAV GG+P+ INP
Sbjct: 67 ---QAASPKGEIPFKPSRVILQDFTGVPVVVDLASMRDAVVKAGGNPELINP 115
>UniRef50_O75944 Cluster: Aconitase; n=34; cellular organisms|Rep:
Aconitase - Homo sapiens (Human)
Length = 600
Score = 87.4 bits (207), Expect = 6e-16
Identities = 54/176 (30%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
++GTDSHT + VM G + KV+ KL G L+ + D+
Sbjct: 9 LIGTDSHTPNGGGLGGISIGVGGRDRVDVMAGIPCELKCTKVIAMKLTGSLSGWTSPKDV 68
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + L G G VE+ GPGV ++S AT+ NM E GAT + FP + R +YL
Sbjct: 69 ILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYL 128
Query: 324 HQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
+T R D+ + LR ++F+D+ P+ + +V+E++L ++ ++GP P
Sbjct: 129 SKTGR----ADI--ASLR--EEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTP 176
>UniRef50_Q0C395 Cluster: Putative 3-isopropylmalate dehydratase,
large subunit; n=1; Hyphomonas neptunium ATCC 15444|Rep:
Putative 3-isopropylmalate dehydratase, large subunit -
Hyphomonas neptunium (strain ATCC 15444)
Length = 463
Score = 73.7 bits (173), Expect = 8e-12
Identities = 82/301 (27%), Positives = 124/301 (41%), Gaps = 28/301 (9%)
Query: 86 RVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPADLVIDHSVQVDFARTPDALNK 145
R++L + TG A+ AA V+D P R+ I + H D AR+P
Sbjct: 28 RLLLHERTGGVALKSLAAAGHRVRD----PARVFSIMDHIVSFRHGRGRDEARSPGG--- 80
Query: 146 NQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVV 205
+ V +E Q DN P GIVH V E G L ++V
Sbjct: 81 --EAFIVETREMAQTAGIHLIDTDN-----PAQGIVHVVAPEL-------GIALPGLTLV 126
Query: 206 GTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVL 265
DSHT + +AE M + P+ + ++ G L+P ++ DL L
Sbjct: 127 CPDSHTCSLGALGALAWGIGSSDAEHAMATGTLRAAKPRQMLIRVAGRLSPGVSAKDLAL 186
Query: 266 TITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQ 325
I S G +E+ G + LSI R T+ NM EF A A DA++L+Y+
Sbjct: 187 YIIARFGSDGGKRCAIEYAGEAISDLSIEGRLTLCNMAVEFAAFTALIAPDAKTLDYV-- 244
Query: 326 TNRPKEKIDV-IESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVS 384
+ RP +E+ L + R ++ F EV+E+D G V VS P+D ++
Sbjct: 245 SGRPFSPSGAQVETALAHWQTLR----TDEGAEFDEVIEVDAGKVAPQVSWGTSPEDSLA 300
Query: 385 V 385
+
Sbjct: 301 L 301
>UniRef50_A5ZNE1 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 416
Score = 72.1 bits (169), Expect = 2e-11
Identities = 51/155 (32%), Positives = 73/155 (47%), Gaps = 9/155 (5%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G G+ HQV +E R G L + G DSHT + M+
Sbjct: 97 GKGVCHQVMIENYVR---PGEL-----IFGADSHTCSYGALGAFGTGVGCTDFLYGMVTG 148
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+L+P+ V + L G+L T+ DL+LTI + + G + +EF G G LSI+DR
Sbjct: 149 TSWVLVPESVKFNLTGKLPEGVTARDLILTIIGEVGANGCNYQVMEFTGEGAKTLSISDR 208
Query: 297 ATVANMCPEFGATLAHFPVDARSLEYLHQTNR-PK 330
T+ NM E GA F D +++EYL + R PK
Sbjct: 209 MTLCNMAVEAGAKTGIFEADEKAMEYLKEHGREPK 243
>UniRef50_Q5K9V9 Cluster: Homoaconitase, mitochondrial precursor;
n=3; Dikarya|Rep: Homoaconitase, mitochondrial precursor
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 728
Score = 67.3 bits (157), Expect = 7e-10
Identities = 57/217 (26%), Positives = 96/217 (44%), Gaps = 10/217 (4%)
Query: 116 DRINPICPADLVIDHSVQVDFARTPD-ALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIV 174
D P+ L + S ++D R P AL+ + + N+++++ ++ A+ +
Sbjct: 68 DNTGPVISKFLSLSCS-KLDNPRQPVFALDHDVQNQSETNQKKYKKIQAFAKEH-GVDFY 125
Query: 175 PPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVML 234
P G GI HQ+ +E + G + VV +DSH+ +A +
Sbjct: 126 PAGRGIGHQIIVE--EGYAWPGKM-----VVASDSHSNHYGGVGCLGTAIVRTDAAGIWA 178
Query: 235 GQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIA 294
+P++V L G L+P T D+++ + V+ +EF G GV LSI
Sbjct: 179 TGKFWWQIPRIVSVSLDGRLSPGVTGKDVIVALAGLFNKDEVLNAAIEFTGSGVEHLSID 238
Query: 295 DRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKE 331
+R T+ANM E+GA FPVD + E+ R E
Sbjct: 239 ERLTIANMTTEWGAVAGVFPVDDKLKEWYQGILRKAE 275
>UniRef50_Q89X98 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=52; Bacteria|Rep: 3-isopropylmalate
dehydratase large subunit 1 - Bradyrhizobium japonicum
Length = 477
Score = 64.5 bits (150), Expect = 5e-09
Identities = 57/222 (25%), Positives = 90/222 (40%), Gaps = 15/222 (6%)
Query: 164 GAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXX 223
G + FD I PG GIVH + E G L +V DSHT
Sbjct: 104 GIRLFD---IDQPGQGIVHVIGPEL-------GLSLPGCLIVCGDSHTCTHGGLGALAFG 153
Query: 224 XXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEF 283
E V+ Q I PK + G + T+ DL+L + H+ + G G VE+
Sbjct: 154 IGSSELTHVLATQTIIQRRPKTMRVTFDGRMPFGVTAKDLILALIGHVGAAGGTGYAVEY 213
Query: 284 FGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRAT 343
G + + I R T+ N+ E GA + D + +Y+ RP E + RA
Sbjct: 214 AGSAIRGMPIEGRLTICNLSVELGAKMGLIAPDQTTFDYVR--GRPYAPQG--EMWERAV 269
Query: 344 KQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSV 385
+R + + D +F V +D+G ++ ++ P+ + V
Sbjct: 270 TAWRTLRS-DSDAMFDREVTIDVGTIIPQITWGTSPEHVLGV 310
>UniRef50_P49367 Cluster: Homoaconitase, mitochondrial precursor;
n=14; Dikarya|Rep: Homoaconitase, mitochondrial
precursor - Saccharomyces cerevisiae (Baker's yeast)
Length = 693
Score = 64.1 bits (149), Expect = 7e-09
Identities = 59/232 (25%), Positives = 97/232 (41%), Gaps = 20/232 (8%)
Query: 175 PPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVML 234
P G GI HQ+ +E + PL + V +DSH+ +A A+
Sbjct: 116 PAGRGIGHQIMIEE----GYAFPL---NMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWA 168
Query: 235 GQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIA 294
+P V +L G+L + D+++ + + V+ +EF G + AL I
Sbjct: 169 TGQTWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPID 228
Query: 295 DRATVANMCPEFGATLAHFPVD-------ARSLEYLHQTNRPKEKIDVIESYLRATKQFR 347
R T+ANM E+GA FPVD L+ L N P+ + +RA ++
Sbjct: 229 HRLTIANMTTEWGALSGLFPVDKTLIDWYKNRLQKLGTNNHPR----INPKTIRALEEKA 284
Query: 348 DYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQDCLTNK 399
++D +++ + +DL + VSGP +VS + QD NK
Sbjct: 285 KIPKADKDAHYAKKLIIDLATLTHYVSGPN--SVKVSNTVQDLSQQDIKINK 334
>UniRef50_UPI00015BAFD3 Cluster: 3-isopropylmalate dehydratase; n=1;
Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydratase - Ignicoccus hospitalis KIN4/I
Length = 429
Score = 63.7 bits (148), Expect = 9e-09
Identities = 48/160 (30%), Positives = 69/160 (43%), Gaps = 11/160 (6%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSV-VGTDSHTTMINXXXXXXXXXXXIEAEAVMLG 235
G+GI HQV +E R P SV VG DSHT +A M+
Sbjct: 97 GTGICHQVMVEE-GRA-------WPGSVFVGADSHTVTYGALGSFATGVGSTDAAIAMMT 148
Query: 236 QAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIAD 295
I +P+ + + L+G+ S DL+L I L+ G EF G G+ + I
Sbjct: 149 GRIWFKVPEALKFNLIGKFREGVMSKDLILKIIGDLKEDGATYMSAEFVGDGLKDMRIDS 208
Query: 296 RATVANMCPEFGATLAHFPVDARSLEYLHQTNR--PKEKI 333
R TV+NM E GA + P D + ++ R PK ++
Sbjct: 209 RLTVSNMVVEMGAKVGLMPADEEVMRFVEGRARGVPKPEL 248
>UniRef50_A5WGT5 Cluster: 3-isopropylmalate dehydratase, large
subunit; n=11; Bacteria|Rep: 3-isopropylmalate
dehydratase, large subunit - Psychrobacter sp. PRwf-1
Length = 478
Score = 63.7 bits (148), Expect = 9e-09
Identities = 60/207 (28%), Positives = 89/207 (42%), Gaps = 12/207 (5%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAI 238
GIVH V E G +L +VV DSHT E E V+ Q +
Sbjct: 118 GIVHVVGPEQ-------GLVLPGMTVVCGDSHTATHGALGCLAHGIGTSEVEHVLATQCL 170
Query: 239 SMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRAT 298
K + ++ GEL T+ D+VL I + + G G +EF G +S+ R T
Sbjct: 171 VQKKSKNMLIRVNGELGAGVTAKDVVLAIIAKIGTAGGTGYAIEFAGEVFENMSMEGRMT 230
Query: 299 VANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVF 358
V NM E GA + VD ++EY+ RP E + +A ++ + + ++ F
Sbjct: 231 VCNMAIEAGARVGMVGVDETTIEYV--KGRPFAPTG--EQWDQAV-EYWNTLHSDEGAHF 285
Query: 359 SEVVELDLGDVVTSVSGPKRPQDRVSV 385
+VELD D+ VS P+ V V
Sbjct: 286 DAIVELDASDIAPQVSWGTSPEMVVDV 312
>UniRef50_A5ZND9 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 423
Score = 62.1 bits (144), Expect = 3e-08
Identities = 37/119 (31%), Positives = 57/119 (47%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
V GTDSHTT E +++ + + +P+ + + GEL S D+
Sbjct: 125 VFGTDSHTTTYGCVGAFSSGIGYTEMASILGTGTMWIKVPETIKVVIDGELPANVMSKDV 184
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
+L + L + G + +EF G V +S+A R T+ANM E GA A F D ++ EY
Sbjct: 185 ILRLIGDLGADGATYRALEFTGSAVKNMSVASRMTIANMAIEAGAKCALFTPDEKTAEY 243
>UniRef50_Q0W1Q4 Cluster: 3-isopropylmalate dehydratase, large
subunit; n=2; Euryarchaeota|Rep: 3-isopropylmalate
dehydratase, large subunit - Uncultured methanogenic
archaeon RC-I
Length = 414
Score = 62.1 bits (144), Expect = 3e-08
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 10/163 (6%)
Query: 162 KWGA-QAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXX 220
+W A Q N+ V G GI HQ+ E G + +VG DSH+
Sbjct: 82 QWAAEQGIKNLYDV--GEGICHQLLPE-------NGFAMPGKVIVGADSHSCTYGAFGAF 132
Query: 221 XXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKF 280
+ + + +P+ + + G+L T D++L I K + S G K
Sbjct: 133 ATGVGATDMAEIYTSGKLWFRVPETIKLTVDGKLPAAVTPKDVILRIAKEVGSDGATYKA 192
Query: 281 VEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+EF+GP + +SIA R T+ NM E G P D ++ +L
Sbjct: 193 MEFYGPVIDHMSIAGRMTLCNMAIEMGGKAGIVPPDEKTFAFL 235
>UniRef50_P81291 Cluster: 3-isopropylmalate dehydratase large
subunit 2; n=3; cellular organisms|Rep:
3-isopropylmalate dehydratase large subunit 2 -
Methanococcus jannaschii
Length = 424
Score = 61.3 bits (142), Expect = 5e-08
Identities = 39/136 (28%), Positives = 59/136 (43%), Gaps = 6/136 (4%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
VVG DSHT + V + +P+ + + + G+L P TS D+
Sbjct: 118 VVGADSHTCTHGAFGAFATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQPYVTSKDV 177
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L+I + G K +F G V +SIA R T+ NM E G D ++++Y+
Sbjct: 178 ILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYV 237
Query: 324 ------HQTNRPKEKI 333
H T RP E I
Sbjct: 238 KEAMKKHGTERPFEVI 253
>UniRef50_Q8TVF2 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=3; cellular organisms|Rep:
3-isopropylmalate dehydratase large subunit 1 -
Methanopyrus kandleri
Length = 418
Score = 60.9 bits (141), Expect = 6e-08
Identities = 47/184 (25%), Positives = 77/184 (41%), Gaps = 16/184 (8%)
Query: 202 DSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATST 261
D +VG DSHT + AV + +P+ ++ GEL +
Sbjct: 115 DVIVGADSHTCTHGALGAFATGIGSTDMAAVFATGKLWFRVPETYRVEITGELPEGVYAK 174
Query: 262 DLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLE 321
D+VL +T + + G +E+ G V +S++DR + NM E GA P D ++LE
Sbjct: 175 DVVLKVTGEIGADGATYMAIEYHGEVVREMSVSDRMCLCNMAIEMGAKTGMVPPDEKTLE 234
Query: 322 YLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQD 381
Y+ + RA + R P+ D + + LD+ D+ V+ P P +
Sbjct: 235 YVKK---------------RAGTEGRP-VEPDPDARYEAELTLDVSDLEPQVAKPFSPDN 278
Query: 382 RVSV 385
V V
Sbjct: 279 VVPV 282
>UniRef50_Q82WI9 Cluster: 3-isopropylmalate dehydratase large
subunit; n=81; cellular organisms|Rep: 3-isopropylmalate
dehydratase large subunit - Nitrosomonas europaea
Length = 470
Score = 60.1 bits (139), Expect = 1e-07
Identities = 53/204 (25%), Positives = 87/204 (42%), Gaps = 16/204 (7%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAI 238
GIVH + E G L +VV DSHT+ E E V+ Q +
Sbjct: 108 GIVHVIGPEQ-------GATLPGMTVVCGDSHTSTHGAFACLAFGIGTSEVEHVLATQCL 160
Query: 239 SMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRAT 298
K + ++ G+L P T+ D+ L + + + G G +EF G + +LS+ R T
Sbjct: 161 VARKSKTMLVRVEGDLPPGVTAKDIALAVIGEIGTAGGTGYAIEFAGSAIRSLSMEGRMT 220
Query: 299 VANMCPEFGATLAHFPVDARSLEYLH-QTNRPKEKI-DVIESYLRATKQFRDYTNPEQDP 356
+ NM E GA D +++Y+ + P+ + D +Y R K ++D
Sbjct: 221 LCNMAIEAGARAGMVGADEVTIDYIKGRPFAPQGALWDQAVAYWRTLKS-------DEDA 273
Query: 357 VFSEVVELDLGDVVTSVSGPKRPQ 380
VF +VEL ++ V+ P+
Sbjct: 274 VFDRMVELKAVNIKPQVTWGTSPE 297
>UniRef50_Q05FR0 Cluster: 3-isopropylmalate dehydratase large
subunit; n=1; Candidatus Carsonella ruddii PV|Rep:
3-isopropylmalate dehydratase large subunit - Carsonella
ruddii (strain PV)
Length = 456
Score = 59.7 bits (138), Expect = 1e-07
Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 22/231 (9%)
Query: 129 DHSVQVDFARTPDALNKN-QDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLE 187
DH+V +F NKN + L+ ++ + F K+ +D I P GI+H + E
Sbjct: 59 DHNVSTNFKHR-FFYNKNLKQLKCLKKNFKKFFFKY----YD---INSPKQGIIHIIASE 110
Query: 188 YLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVG 247
++++ G + ++ G DSHTT + E + Q I K +
Sbjct: 111 --SKILLPGMI----AICG-DSHTTTNGALSLIANGIGTTDIEIGISTQCIIQKKLKNMK 163
Query: 248 YKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFG 307
+ LN TS DL+L I K + S G G +EF G + +LSI+++ T+ NM E G
Sbjct: 164 IVINNFLNKNVTSKDLILFIIKKITSKGGTGYSIEFKGDCIKSLSISEKMTLCNMSIEAG 223
Query: 308 ATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVF 358
+ ++ D +++ + K+KI I+ ++ KQ + D F
Sbjct: 224 SKISIISPDVKTINFY------KKKIKNIKKFINYLKQIKSNKKSFYDKTF 268
>UniRef50_A4M821 Cluster: Homoaconitate hydratase family protein;
n=5; Bacteria|Rep: Homoaconitate hydratase family
protein - Petrotoga mobilis SJ95
Length = 419
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 8/154 (5%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G GI HQ+ E G L V+G DSHT + M
Sbjct: 98 GEGICHQLMPE-------KGHALPGQIVIGADSHTCTYGALNCFSTGVGSTDLAIAMASG 150
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+ +P+ + L G L+ S D+ L + K++ + G K VEF GP + LS+ R
Sbjct: 151 KLWFKVPQSIKIVLEGSLSKGIYSKDVALYVIKNMTANGATYKAVEFEGPVIDNLSVEAR 210
Query: 297 ATVANMCPEFGATLAHFPVDARSLEYL-HQTNRP 329
T++NM E GA + +D ++ ++ +T++P
Sbjct: 211 FTISNMSVEMGAKVGLMKLDEKAENWIKERTDKP 244
>UniRef50_A0HK99 Cluster: Aconitate hydratase-like; n=3;
Burkholderiales|Rep: Aconitate hydratase-like -
Comamonas testosteroni KF-1
Length = 659
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
VVGTDSHT + + A+ + +P+ + L GEL+ T+ D+
Sbjct: 343 VVGTDSHTPHSGALGCVAFGIGTTDMANAFVTGAVRLTVPESLRIVLDGELSANVTAKDV 402
Query: 264 VLTITK--HLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLE 321
VL + ++R+ G VGK EF G + +S +RAT+ NM E G DA ++
Sbjct: 403 VLHLLAQPYIRAGGGVGKVFEFTGAAIARMSTDERATLTNMSAELGGFTGIVAPDAETVR 462
Query: 322 YLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
+L + + I+ D+ + + D ++ + +D V V+ P P
Sbjct: 463 FLLERRAIRFVIE-------------DWMHSDPDASYARTIRIDCSAVPVMVASPGDP 507
>UniRef50_A6FCI8 Cluster: Isopropylmalate isomerase large subunit;
n=1; Moritella sp. PE36|Rep: Isopropylmalate isomerase
large subunit - Moritella sp. PE36
Length = 468
Score = 58.8 bits (136), Expect = 2e-07
Identities = 51/209 (24%), Positives = 84/209 (40%), Gaps = 12/209 (5%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G GI H + E G +L ++V DSHTT + E V+ Q
Sbjct: 104 GQGITHVIAPEQ-------GRVLPGSTLVCCDSHTTTHGAFGALAFGIGTSQVEHVLATQ 156
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+ + + + G N + DL L I + + G G +E+ G V LS+ R
Sbjct: 157 TLRAIPFNTMRVNVTGAYNEGVDAKDLALFIINEIGTGGGQGCVIEYTGEAVSQLSMEQR 216
Query: 297 ATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDP 356
T+ NM E GA+ D ++ YL + + + + ++ T ++ Y + D
Sbjct: 217 MTLCNMTVEAGASAGIISPDQTTVSYLKE-KLAERNVTISDA---DTTKWLTYAT-DMDA 271
Query: 357 VFSEVVELDLGDVVTSVSGPKRPQDRVSV 385
VF + VE+D V +S P + V
Sbjct: 272 VFDKYVEIDAAKVPKMISWGTNPSQVIPV 300
>UniRef50_P07264 Cluster: 3-isopropylmalate dehydratase; n=473;
cellular organisms|Rep: 3-isopropylmalate dehydratase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 779
Score = 58.8 bits (136), Expect = 2e-07
Identities = 53/207 (25%), Positives = 86/207 (41%), Gaps = 12/207 (5%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAI 238
GIVH + E G L +VV DSHT+ E E V+ Q I
Sbjct: 119 GIVHTIGPE-------EGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTI 171
Query: 239 SMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRAT 298
K + + G+L+P TS DL+L I + + G G +EF G + ALS+ R +
Sbjct: 172 IQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMS 231
Query: 299 VANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVF 358
+ NM E GA D + +Y RP + +A ++ ++ F
Sbjct: 232 MCNMAIEAGARAGMIKPDETTFQY--TKGRPLAPKGA--EWEKAVAYWKT-LKTDEGAKF 286
Query: 359 SEVVELDLGDVVTSVSGPKRPQDRVSV 385
+ ++ DV+ +++ PQD + +
Sbjct: 287 DHEINIEAVDVIPTITWGTSPQDALPI 313
>UniRef50_A4VXS4 Cluster: 3-isopropylmalate dehydratase large
subunit; n=2; Streptococcus suis|Rep: 3-isopropylmalate
dehydratase large subunit - Streptococcus suis (strain
05ZYH33)
Length = 439
Score = 58.4 bits (135), Expect = 3e-07
Identities = 65/257 (25%), Positives = 101/257 (39%), Gaps = 23/257 (8%)
Query: 129 DHSVQ-VDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLE 187
DH+V VD D ++K Q +N E F + A ++ GIVH V E
Sbjct: 63 DHNVPTVDIHNIRDVISKAQMDALAKNIEDFG-IPHAAHGSEHQ-------GIVHMVGPE 114
Query: 188 YLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVG 247
TG +V DSHT E E V+ Q I + PK +
Sbjct: 115 -------TGRTQPGKFIVCGDSHTATHGAFGAIAFGIGTSEVEHVLATQTIWQVKPKRLL 167
Query: 248 YKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFG 307
+ VG+ + D +L + +G VEF GP + LS+ +R T+ NM EFG
Sbjct: 168 VEFVGQAQRGVYAKDFILALIARYGVDCGLGHVVEFAGPVIDRLSMEERMTICNMSIEFG 227
Query: 308 ATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLG 367
+ + D + +YL D A +++ + + D V+ + + LD+
Sbjct: 228 SKMGIMAPDQTTFDYLRGRECAPADFDA------AVADWKELYS-DADTVYDKHLVLDVS 280
Query: 368 DVVTSVSGPKRPQDRVS 384
D+ V+ P VS
Sbjct: 281 DLAPMVTWGTTPAMGVS 297
>UniRef50_Q9WYC7 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=8; cellular organisms|Rep:
3-isopropylmalate dehydratase large subunit 1 -
Thermotoga maritima
Length = 418
Score = 58.4 bits (135), Expect = 3e-07
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVM-LG 235
G GI HQ+ E + V G D V G DSHT + + LG
Sbjct: 95 GDGISHQILAE---KYVKPG-----DLVAGADSHTCTAGGLGAFGTGMGSTDVAIIFGLG 146
Query: 236 QAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIAD 295
Q +P+ + + G+L + D++L I + L S G K +EF G + +++ D
Sbjct: 147 QNW-FKVPETIKVVVNGKLQDGVYAKDIILEIARILGSDGATYKALEFHGSCIENMNVED 205
Query: 296 RATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKE 331
R T++NM E GA P D ++ E+L + R ++
Sbjct: 206 RLTISNMAVEVGAKAGLMPSDEKTREFLKKMGREED 241
>UniRef50_Q4WUL6 Cluster: Homoaconitase, mitochondrial precursor;
n=10; Pezizomycotina|Rep: Homoaconitase, mitochondrial
precursor - Aspergillus fumigatus (Sartorya fumigata)
Length = 777
Score = 57.6 bits (133), Expect = 6e-07
Identities = 47/206 (22%), Positives = 86/206 (41%), Gaps = 11/206 (5%)
Query: 175 PPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVML 234
P G G+ HQ+ +E F G + V +DSH+ M +A +
Sbjct: 173 PAGHGVGHQIMIE--EGYAFPGTV-----TVASDSHSNMYGGVGCLGTPMVRTDAATIWA 225
Query: 235 GQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPG--VGALS 292
+P + + G L T D+++ ++ V+ +EF G + +LS
Sbjct: 226 TGRTWWKVPPIAKVQFTGTLPEGVTGKDVIVALSGLFNKDEVLNYAIEFTGSEETMKSLS 285
Query: 293 IADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYL--RATKQFRDYT 350
+ R T+ANM E+GA FP+D+ ++L + + + R + F + T
Sbjct: 286 VDTRLTIANMTTEWGALTGLFPIDSTLEQWLRHKAATASRTETARRFAEERINELFANPT 345
Query: 351 NPEQDPVFSEVVELDLGDVVTSVSGP 376
++ +++ + LDL + VSGP
Sbjct: 346 VADRGARYAKYLYLDLSTLSPYVSGP 371
>UniRef50_Q1AVC5 Cluster: Homoaconitate hydratase family protein;
n=2; Bacteria|Rep: Homoaconitate hydratase family
protein - Rubrobacter xylanophilus (strain DSM 9941 /
NBRC 16129)
Length = 424
Score = 57.2 bits (132), Expect = 8e-07
Identities = 39/144 (27%), Positives = 56/144 (38%), Gaps = 3/144 (2%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
+ G DSHT + A + +P + + G DL
Sbjct: 118 IAGGDSHTCTYGALGAFGTGLGSTDIAACLAFGEFWQQVPGTIQVEFTGHKGSFVAGKDL 177
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + + G +EF G G +LS+ DR VANM E GA FP D + YL
Sbjct: 178 ILAVIADIGVGGGANAVLEFVGEGAASLSLDDRLAVANMAVEAGAETGIFPADEVTARYL 237
Query: 324 -HQTNRP--KEKIDVIESYLRATK 344
+ +R E+ D SY+R K
Sbjct: 238 DRRADREWHPERSDPDASYVRKVK 261
>UniRef50_A2SQ03 Cluster: 3-isopropylmalate dehydratase; n=5;
Methanomicrobia|Rep: 3-isopropylmalate dehydratase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 417
Score = 56.4 bits (130), Expect = 1e-06
Identities = 36/142 (25%), Positives = 59/142 (41%)
Query: 182 HQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISML 241
H+V +++ G L + VVG DSH+ + + +
Sbjct: 91 HEVGCGICHQIMSEGVCLPGEIVVGADSHSCTLGALGAFSTGVGATDMAGIWATGGTWFR 150
Query: 242 LPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVAN 301
+P+ + L G+L+ D+ L+ K L G K +EF G G + + R T++N
Sbjct: 151 VPESISIVLSGKLSGHTEPKDVALSYVKALGMDGGTYKALEFIGDGAAGMPVEGRLTLSN 210
Query: 302 MCPEFGATLAHFPVDARSLEYL 323
M E GA F DA + E+L
Sbjct: 211 MAVETGAKTGLFYADALTREHL 232
>UniRef50_A7NXJ3 Cluster: Chromosome chr5 scaffold_2, whole genome
shotgun sequence; n=8; Magnoliophyta|Rep: Chromosome
chr5 scaffold_2, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 507
Score = 56.0 bits (129), Expect = 2e-06
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 1/131 (0%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
++GTDSHT +A V+ I + +P + + + GE+ + DL
Sbjct: 211 LLGTDSHTCTAGAFGQFATGIGNTDAAFVLGTGKILLKVPPTLRFVMDGEMPNYLLAKDL 270
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L I + G K +EF G V +L++ +R T+ NM E G P D+ + +YL
Sbjct: 271 ILQIIGEISVSGATYKSMEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYL 330
Query: 324 H-QTNRPKEKI 333
+T+ P E +
Sbjct: 331 EDKTSLPYEPV 341
>UniRef50_Q2GN26 Cluster: Homoaconitase, mitochondrial precursor;
n=9; Pezizomycotina|Rep: Homoaconitase, mitochondrial
precursor - Chaetomium globosum (Soil fungus)
Length = 797
Score = 55.2 bits (127), Expect = 3e-06
Identities = 54/227 (23%), Positives = 92/227 (40%), Gaps = 19/227 (8%)
Query: 175 PPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVML 234
P G GI HQ+ +E + G L V +DSH+ M +A ++
Sbjct: 175 PAGRGIGHQIMIE--EGYAWPGTL-----TVASDSHSNMYGGVAALGTPVVRTDAASIWA 227
Query: 235 GQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGV--GALS 292
+P + G L T D+++ + V+ +EF G + +L
Sbjct: 228 TGQTWWQIPPIAKVTFTGVLPRGVTGKDVIIALCALFNQDEVLNHAIEFTGSDLTLSSLP 287
Query: 293 IADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDV-IESYLRAT-----KQF 346
I DR T++NM E+GA FP+D+ +L ++ + R T + F
Sbjct: 288 IDDRLTISNMTTEWGAVAGIFPIDSTLKSWLRAKATVSAMLNPDLGGKARITHDKIEELF 347
Query: 347 RDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQ 393
RD P+ +++ + L+L + V+GP + V VA KD +
Sbjct: 348 RDPPKPDLGATYAKSLYLNLSTLSPFVAGP----NSVKVATPVKDLE 390
>UniRef50_O67078 Cluster: 3-isopropylmalate dehydratase large
subunit; n=50; cellular organisms|Rep: 3-isopropylmalate
dehydratase large subunit - Aquifex aeolicus
Length = 432
Score = 55.2 bits (127), Expect = 3e-06
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 1/135 (0%)
Query: 196 GPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELN 255
G ++ D VVG DSHT + M + + +P+ + + G+L
Sbjct: 110 GLVVPGDLVVGADSHTCTYGALGAFATGVGSTDIAYAMATGEVWLRVPESMKFIFYGKLK 169
Query: 256 PLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPV 315
P DL+L + G + + +EF G + LS+ R T+ANM E G
Sbjct: 170 PWVMGKDLILYTIGQIGVDGALYRAMEFDGETIRNLSMEQRFTIANMAIEAGGKSGIISP 229
Query: 316 DARSLEYLHQ-TNRP 329
D +++EY+ Q RP
Sbjct: 230 DEKTIEYVKQRAKRP 244
>UniRef50_Q65VS0 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=7; Proteobacteria|Rep: 3-isopropylmalate
dehydratase large subunit 1 - Mannheimia
succiniciproducens (strain MBEL55E)
Length = 475
Score = 55.2 bits (127), Expect = 3e-06
Identities = 43/167 (25%), Positives = 71/167 (42%), Gaps = 7/167 (4%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
+ DSHTT E E ++ Q + K + L G+L T+ D+
Sbjct: 130 IAAGDSHTTTYGAFGAFGFGIGTSEIEHLLATQTLVYKKLKNMRVTLTGKLPFGTTAKDV 189
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
++ + + + G +EF G + LS+ R T+ NM E GA A D + EY+
Sbjct: 190 IMALVAKIGADGATNYAIEFCGEVIDELSVEGRMTICNMAVECGARGAFMAPDEKVYEYI 249
Query: 324 HQTNR-PKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDV 369
T R PK E + A ++R + + D VF + + +D D+
Sbjct: 250 KGTPRAPKG-----EMWDLAIAEWRKLKS-DNDAVFDKEIHMDCSDL 290
>UniRef50_Q0PQM4 Cluster: Aconitase A; n=1; Endoriftia persephone
'Hot96_1+Hot96_2'|Rep: Aconitase A - Endoriftia
persephone 'Hot96_1+Hot96_2'
Length = 236
Score = 54.8 bits (126), Expect = 4e-06
Identities = 27/70 (38%), Positives = 41/70 (58%)
Query: 262 DLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLE 321
D++L + + G G E+ GPGV +LS+ +RAT+ NM E GAT + FP D R+ E
Sbjct: 4 DVILKMLEINGVKGGKGVIFEYAGPGVASLSLTERATITNMGAEMGATTSIFPSDERTQE 63
Query: 322 YLHQTNRPKE 331
+L R ++
Sbjct: 64 FLESRGRGQD 73
>UniRef50_Q5AVN8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 326
Score = 54.8 bits (126), Expect = 4e-06
Identities = 39/135 (28%), Positives = 59/135 (43%), Gaps = 12/135 (8%)
Query: 275 GVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKID 334
G G +E+FG G +S ATV NM E GAT + FP A EYL RP D
Sbjct: 136 GSTGSIIEYFGLGAQTISATGMATVCNMGAESGATTSIFPYTASMAEYLRANRRP----D 191
Query: 335 VIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMKKDFQD 394
+ + + R E D +++++DL + + GP P +S I K F
Sbjct: 192 MAAAVETIAYELRSDEGAEYD----QIIDIDLSSLEPHIDGPFTPD--LSTPISK--FGS 243
Query: 395 CLTNKPVPIAILSGV 409
+ + P + +G+
Sbjct: 244 AVIDNEWPSTLTAGL 258
>UniRef50_A6DRT0 Cluster: 3-isopropylmalate dehydratase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydratase -
Lentisphaera araneosa HTCC2155
Length = 433
Score = 54.4 bits (125), Expect = 5e-06
Identities = 45/183 (24%), Positives = 77/183 (42%), Gaps = 16/183 (8%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
++GTDSHT +A M + +P+ + + L G+L + DL
Sbjct: 124 ILGTDSHTCTHGALGAFATGIGNTDAAFTMGTGRTWLKIPETIKFVLNGKLPKTMMAKDL 183
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + + G +EF GP + LSI +R T+ NM E G DA+ Y+
Sbjct: 184 ILHMIGEIGFSGATYCAMEFEGPVIDELSIEERMTICNMAIEAGGKNGVIAADAKVEAYV 243
Query: 324 HQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRV 383
KE+ DV + +A + D + +V E++ ++ +V+ P P R
Sbjct: 244 ------KERTDVPYTLFKA----------DADADYKDVYEINCSELEPTVAIPSAPDKRK 287
Query: 384 SVA 386
V+
Sbjct: 288 GVS 290
>UniRef50_A0ZF76 Cluster: 3-isopropylmalate dehydratase, LeuC
subunit; n=2; Nostocaceae|Rep: 3-isopropylmalate
dehydratase, LeuC subunit - Nodularia spumigena CCY 9414
Length = 574
Score = 54.4 bits (125), Expect = 5e-06
Identities = 62/264 (23%), Positives = 105/264 (39%), Gaps = 36/264 (13%)
Query: 126 LVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLK-WGAQAFDNMLIVPPG--SGIVH 182
LV DH +QV+ R N V +E F K G FD IV PG +GI H
Sbjct: 211 LVADHFIQVNDIRNDQKAN-------VMYQEMIDFAKKQGCHLFD---IVSPGEAAGICH 260
Query: 183 QVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLL 242
+ L F P + + GTDSHT + + + + +
Sbjct: 261 VL----LPEKGFVRPGM---IIAGTDSHTCTYGALGAFSAGVGTTDMANIYAMGDMWIRV 313
Query: 243 PKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANM 302
P + ++L G L P ++ D++L I + G K +EF G + + +R T+ANM
Sbjct: 314 PSTLVFELSGTLPPHISAKDIILFILGQIGCAGATSKVMEFRGSILEQMPFDERLTLANM 373
Query: 303 CPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVV 362
E GA D + Y+ R+ ++F + + D + +V
Sbjct: 374 AIECGAICGLIVPDETTRNYVRS---------------RSDQEFEELI-ADPDAEYEKVY 417
Query: 363 ELDLGDVVTSVSGPKRPQDRVSVA 386
+ D+ ++ ++ P +P V ++
Sbjct: 418 KFDISNLEPQIARPPKPDQVVPIS 441
>UniRef50_Q5FUG3 Cluster: 3-isopropylmalate dehydratase large
subunit; n=120; Bacteria|Rep: 3-isopropylmalate
dehydratase large subunit - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 475
Score = 54.4 bits (125), Expect = 5e-06
Identities = 45/179 (25%), Positives = 75/179 (41%), Gaps = 5/179 (2%)
Query: 203 SVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTD 262
++V DSHT+ E E V+ Q I K + + G++ P T+ D
Sbjct: 128 TIVCGDSHTSTHGALGSLAFGIGTSEVEHVLATQTILQKPAKNMRVSVEGKVGPGVTAKD 187
Query: 263 LVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
++L I + + G G +EF G + L +A R T+ NM E GA D + Y
Sbjct: 188 ILLAIIGRIGTAGGTGHVIEFAGSAIRDLDMAGRMTLCNMSIEAGARAGLVAPDETTFAY 247
Query: 323 LHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQD 381
+ RP E++ +A +R + + F V L +++ SV+ PQ+
Sbjct: 248 V--KGRPFAPKG--EAFEQACDYWRSLAS-DDGAYFDTEVTLAAEEIIPSVTWGTSPQN 301
>UniRef50_Q6L0K5 Cluster: 3-isopropylmalate dehydratase large
subunit; n=2; Thermoplasmatales|Rep: 3-isopropylmalate
dehydratase large subunit - Picrophilus torridus
Length = 413
Score = 53.6 bits (123), Expect = 9e-06
Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 17/178 (9%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
+ G DSHT EA + + +P+ ++ G D+
Sbjct: 114 IAGADSHTNTYGALSCVSVGIGSTEAGVIFGTGRMWFKVPETDLIRINGRPKKGVYGKDI 173
Query: 264 VLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYL 323
+L + + + G K +EF G + L I +R T+ANM E GA + F D ++L+Y+
Sbjct: 174 ILNVLSRIGNGGSAYKCMEFTGSTIDYLDINERMTMANMTTEAGAKCSFFNADEKTLDYI 233
Query: 324 HQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQD 381
N+ + K ++D N E +S ++++D ++ SV+ P P +
Sbjct: 234 R--NKTND-----------YKIYKDDENAE----YSRIIDIDASEIEPSVAIPNSPDN 274
>UniRef50_A0RXN9 Cluster: 3-isopropylmalate dehydratase large
subunit; n=2; Thermoprotei|Rep: 3-isopropylmalate
dehydratase large subunit - Cenarchaeum symbiosum
Length = 429
Score = 53.2 bits (122), Expect = 1e-05
Identities = 42/164 (25%), Positives = 70/164 (42%), Gaps = 2/164 (1%)
Query: 198 LLHPDSV-VGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNP 256
L+ P V VG DSHT + V+L I +P+ V +L G L P
Sbjct: 123 LVLPGEVYVGGDSHTNTTGALGAFACGLGHTDMAYVLLYGKIWFKVPETVLLRLNGALPP 182
Query: 257 LATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVD 316
+ D +L I + + G + ++F G G+ +S+ R T+ANM E GA D
Sbjct: 183 HVMAKDYILRIIGDMGTDGGAYRTMQFAGTGITEMSVEGRLTLANMTTEAGAKNGIIEAD 242
Query: 317 ARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSE 360
++ YL K + + ++ F +Y E +P+ ++
Sbjct: 243 KKTAGYLSSRGATGIKPVIGDDDAEYSEVF-EYEGSEMEPLVAK 285
>UniRef50_A3LRP7 Cluster: 3-isopropylmalate dehydratase; n=1; Pichia
stipitis|Rep: 3-isopropylmalate dehydratase - Pichia
stipitis (Yeast)
Length = 677
Score = 52.8 bits (121), Expect = 2e-05
Identities = 53/223 (23%), Positives = 92/223 (41%), Gaps = 21/223 (9%)
Query: 164 GAQAFDNMLIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXX 223
GA+ D PP + I+H E+ G L ++G DSHT
Sbjct: 91 GAKELDIKDYQPPNTTIMHT---EFYRERAQPGML-----IIGADSHTCSSGALGCLAVG 142
Query: 224 XXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVG-KFVE 282
+ ++ +P+ + ++VG+ N D +L I K + + + VE
Sbjct: 143 LGTSDVVFPLITGETFFQIPETLKIEIVGKPNFGIGGKDTILHILKEFKRNTIASNRAVE 202
Query: 283 FFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRA 342
+ G G+ LS R ++NM EFGA F D ++ ++++ P K D +
Sbjct: 203 YDGQGLQYLSCDARFAISNMSTEFGALAGVFVPDQQTSAFINRRKNPIFKRDSL------ 256
Query: 343 TKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSV 385
Y P++ + EV E++LG+VV ++ P + V V
Sbjct: 257 ------YFRPDEGANYVEVREINLGEVVPYIALFPSPDNVVPV 293
>UniRef50_Q1LAU9 Cluster: Homoaconitate hydratase family protein;
n=8; Burkholderiales|Rep: Homoaconitate hydratase family
protein - Ralstonia metallidurans (strain CH34 / ATCC
43123 / DSM 2839)
Length = 440
Score = 52.0 bits (119), Expect = 3e-05
Identities = 49/204 (24%), Positives = 82/204 (40%), Gaps = 11/204 (5%)
Query: 178 SGIVHQVNLEYLARVVFT--GPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLG 235
+GI + ++ E + VV G +L +VG DSH+ E V+
Sbjct: 103 AGIQNFIDNEGICHVVLPERGHILPGRFIVGGDSHSPTGGAFGAYMFGIGATEMAGVLAT 162
Query: 236 QAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIAD 295
I + +P + + G L+ + D++L + L G + +E+ G V LS+ +
Sbjct: 163 GEIWLRVPNTIRVEWQGTLSDGVCAKDIMLFLCATLGMAGGRYEVIEYTGSTVKTLSMQE 222
Query: 296 RATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQD 355
R T+ NM E GA A DA ++ +L + IE R + +
Sbjct: 223 RMTLTNMSTELGAQTALIAPDATTMAWLADAGVDAATLAAIEP--------RQWRSDADA 274
Query: 356 PVFSEVVELDLGDVVTSVSGPKRP 379
PV + D G +V V+ P P
Sbjct: 275 PVLA-THRFDAGTLVPQVAAPHSP 297
>UniRef50_Q9RTI6 Cluster: 3-isopropylmalate dehydratase large
subunit 2; n=3; Bacteria|Rep: 3-isopropylmalate
dehydratase large subunit 2 - Deinococcus radiodurans
Length = 431
Score = 51.6 bits (118), Expect = 4e-05
Identities = 45/195 (23%), Positives = 78/195 (40%), Gaps = 16/195 (8%)
Query: 189 LARVVF--TGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVV 246
+A VV TG + ++V DSHT + + + +P+ +
Sbjct: 102 IAHVVLENTGLMKPGQTLVSGDSHTCNAGALGAFATGVGSTDLAGAIYAGKVWFKVPETM 161
Query: 247 GYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEF 306
++ G+ NP T D+VL + K + + G +E+ G + L + R T+ NM E
Sbjct: 162 LIRVTGKTNPGVTPKDIVLEVIKQIGADGANYMVMEWVGDYIDQLDMEGRFTLTNMAIEA 221
Query: 307 GATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDL 366
G VD + Y+ Q E Q+ +Y + + D + VVE+D
Sbjct: 222 GGKTGIVAVDDTTRAYMQQRGVSPE-------------QYTEYQS-DPDAKYKVVVEIDA 267
Query: 367 GDVVTSVSGPKRPQD 381
V +V+ P P +
Sbjct: 268 AQVEPTVAYPHIPSN 282
>UniRef50_UPI00006D922D Cluster: COG0065: 3-isopropylmalate
dehydratase large subunit; n=1; Pseudomonas aeruginosa
2192|Rep: COG0065: 3-isopropylmalate dehydratase large
subunit - Pseudomonas aeruginosa 2192
Length = 329
Score = 50.4 bits (115), Expect = 9e-05
Identities = 46/146 (31%), Positives = 61/146 (41%), Gaps = 10/146 (6%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAI 238
GIVH V E G L +VV DSHT+ E E V+ Q +
Sbjct: 112 GIVHVVGPEQ-------GATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCL 164
Query: 239 SMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRAT 298
K + K+ G L T+ D+VL + + + G G +EF G + LSI R T
Sbjct: 165 VAKKMKNMLVKVEGRLPAGVTAKDIVLAVIGRIGTAGGNGHAIEFAGSAIRDLSIEGRMT 224
Query: 299 VANMCPEFGA---TLAHFPVDARSLE 321
+ NM E GA +A P D R E
Sbjct: 225 ICNMSIEAGARVGLVARRPEDHRLRE 250
>UniRef50_Q8PUG1 Cluster: 3-isopropylmalate dehydratase large
subunit 2; n=30; Archaea|Rep: 3-isopropylmalate
dehydratase large subunit 2 - Methanosarcina mazei
(Methanosarcina frisia)
Length = 420
Score = 50.4 bits (115), Expect = 9e-05
Identities = 45/181 (24%), Positives = 72/181 (39%), Gaps = 3/181 (1%)
Query: 202 DSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATST 261
D +VG+DSHT + AV + +P+ +++ G+L S
Sbjct: 116 DLIVGSDSHTCAYGSLGAFSTGIGSTDMAAVFATGKLWFRVPETFRFEVEGKLPERVYSK 175
Query: 262 DLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLE 321
DL+L + + GV E+ G + +LSI +R T++NM E G D +
Sbjct: 176 DLILHLIGDVGVEGVRYMAAEYAGSTIRSLSIPERMTMSNMAIEMGGKAGIIEADEVTEA 235
Query: 322 YLHQTNRPKEKIDVIESYLRATK--QFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
YL + P K+D K R Y + +P + +D V+ V G K
Sbjct: 236 YLKE-RIPGFKLDPYWKSDEGAKYLDIRYYDVSDLEPQVACPHNVDNVKPVSEVEGTKLD 294
Query: 380 Q 380
Q
Sbjct: 295 Q 295
>UniRef50_A0UZT1 Cluster: Homoaconitate hydratase family protein;
n=1; Clostridium cellulolyticum H10|Rep: Homoaconitate
hydratase family protein - Clostridium cellulolyticum
H10
Length = 418
Score = 49.6 bits (113), Expect = 2e-04
Identities = 37/133 (27%), Positives = 50/133 (37%)
Query: 202 DSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATST 261
D VVG DSHT + V + +P+ GEL +
Sbjct: 116 DIVVGVDSHTCTYGGLSAFSTGVGSTDMACVWATGKLWFRVPETTKIIFSGELPKGVYAK 175
Query: 262 DLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLE 321
DL L + L G +EF G + L I+ R T+ NM E GA DA + +
Sbjct: 176 DLALYLIGQLGINGANYDMLEFDGELIKNLDISSRLTLCNMVIEMGAKAGIINADAVTQK 235
Query: 322 YLHQTNRPKEKID 334
Y + N E ID
Sbjct: 236 YFREKNLKTEDID 248
>UniRef50_Q58409 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=7; cellular organisms|Rep:
3-isopropylmalate dehydratase large subunit 1 -
Methanococcus jannaschii
Length = 420
Score = 49.6 bits (113), Expect = 2e-04
Identities = 47/206 (22%), Positives = 84/206 (40%), Gaps = 18/206 (8%)
Query: 177 GSGIVHQVNLE-YLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLG 235
G GI HQ+ E Y+ +F V G DSHT + +
Sbjct: 94 GEGICHQILAENYVLPNMF---------VAGGDSHTCTHGAFGAFATGFGATDMAYIYAT 144
Query: 236 QAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIAD 295
+ +PK + +VG+ N ++ D+VL + K + G +E+ G V + +
Sbjct: 145 GETWIKVPKTIRVDIVGK-NENVSAKDIVLRVCKEIGRRGATYMAIEYGGEVVKNMDMDG 203
Query: 296 RATVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQD 355
R T+ NM E G D + +YL K++ + + + K+ R N ++
Sbjct: 204 RLTLCNMAIEMGGKTGVIEADEITYDYL------KKERGLSDEDIAKLKKERITVNRDEA 257
Query: 356 PVFSEVVELDLGDVVTSVSGPKRPQD 381
+ E +E+D+ D+ V+ P P +
Sbjct: 258 NYYKE-IEIDITDMEEQVAVPHHPDN 282
>UniRef50_Q7WPW8 Cluster: Aconitase family protein; n=2;
Bordetella|Rep: Aconitase family protein - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 436
Score = 48.8 bits (111), Expect = 3e-04
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 242 LPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVAN 301
+P V +L G L D+ L + + LR + G +EF GPGV + + R VAN
Sbjct: 159 VPPCVRIRLSGRLPKGVLGKDIYLRLLQDLRGK-LEGCAIEFDGPGVATMPLDVRMAVAN 217
Query: 302 MCPEFGATLAHFPVDARSLEYLHQTNR 328
P GAT FP D L+YL R
Sbjct: 218 GAPHIGATTMIFPSDDILLDYLRPRAR 244
>UniRef50_Q4AFY9 Cluster: Aconitate hydratase, C-terminal:Aconitate
hydratase, N-terminal; n=1; Chlorobium phaeobacteroides
BS1|Rep: Aconitate hydratase, C-terminal:Aconitate
hydratase, N-terminal - Chlorobium phaeobacteroides BS1
Length = 495
Score = 48.8 bits (111), Expect = 3e-04
Identities = 40/191 (20%), Positives = 78/191 (40%), Gaps = 20/191 (10%)
Query: 203 SVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTD 262
+ V TDSH ++ + A + +P V + G+ ++ D
Sbjct: 7 TAVTTDSHANILGAIGAFGQGMGDKDIAAAFHKGKVWFKVPASVKITITGKRPGNVSAKD 66
Query: 263 LVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
+VL + + ++G VEF+G V AL++ +R T+A+M E G + F + + +
Sbjct: 67 IVLNLLHQFGANQLLGYSVEFYGEAVDALTLDERITIASMGTEMGVIILLFTPNDEIMRF 126
Query: 323 LHQTNRPKEKIDVIESYLRATKQFRDYTNPEQD--PVFSEVVELDLGDVVTSVSGPKRPQ 380
+ K + P+ D V+ + + +D+ V VS P +P
Sbjct: 127 CEE------------------KTGKKLIKPQADTGAVYEKELSIDISTFVPMVSRPGKPH 168
Query: 381 DRVSVAIMKKD 391
D V + + +K+
Sbjct: 169 DTVDINLTRKN 179
>UniRef50_Q4WBR0 Cluster: Aconitase family protein; n=7;
Pezizomycotina|Rep: Aconitase family protein -
Aspergillus fumigatus (Sartorya fumigata)
Length = 811
Score = 48.4 bits (110), Expect = 3e-04
Identities = 44/184 (23%), Positives = 75/184 (40%), Gaps = 13/184 (7%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
++G+DSHT + ++ + +P+ + +LVG P D+
Sbjct: 254 IIGSDSHTCSSGALGCLAIGLGAADVTLPLVTGETWVKVPESISIRLVGVPKPGIGGKDV 313
Query: 264 VLTITKHLRSLGVVG-KFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
+L I + L+ V + VEF G GV LS R + NM E F D + +
Sbjct: 314 ILYILQQLKRNTVASDRIVEFSGAGVQYLSADARFAICNMTAELCGITGIFVPDQITRAF 373
Query: 323 LHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDR 382
+ NR L+ K Y P+ D ++ +++DL +V + + RP D
Sbjct: 374 V--ANRR----------LQRHKNLITYFRPDNDAQYAAELDIDLANVQSFFARYPRPDDV 421
Query: 383 VSVA 386
V V+
Sbjct: 422 VPVS 425
>UniRef50_Q8KER8 Cluster: 3-isopropylmalate dehydratase, large
subunit, putative; n=9; cellular organisms|Rep:
3-isopropylmalate dehydratase, large subunit, putative -
Chlorobium tepidum
Length = 431
Score = 47.2 bits (107), Expect = 8e-04
Identities = 43/177 (24%), Positives = 78/177 (44%), Gaps = 4/177 (2%)
Query: 201 PDSVV-GTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLAT 259
P +V+ GTDSHT +A ++ + +P + + G++ T
Sbjct: 120 PGTVLFGTDSHTCTSGAFGMFGSGIGNTDAAFILGTGKLWEKVPDSMKFTFEGQMPEYLT 179
Query: 260 STDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARS 319
+ DL+L I + + G + +EF G V +L I +R T+ NM E G DA +
Sbjct: 180 AKDLILQILGDITTDGATYRAMEFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVT 239
Query: 320 LEYLH-QTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSG 375
++ +T++P E I + + +R Y + +P+ ++ D V SV+G
Sbjct: 240 EAFVKARTSKPYE-IFTSDPDAQYHSMYR-YNVEKMEPIVAKPHSPDNRATVHSVAG 294
>UniRef50_Q74BX5 Cluster: 3-isopropylmalate dehydratase, large
subunit, putative; n=14; Bacteria|Rep: 3-isopropylmalate
dehydratase, large subunit, putative - Geobacter
sulfurreducens
Length = 427
Score = 47.2 bits (107), Expect = 8e-04
Identities = 40/177 (22%), Positives = 74/177 (41%), Gaps = 6/177 (3%)
Query: 203 SVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTD 262
+V+ DSHT + E +L + PK + L G L + D
Sbjct: 116 TVIMGDSHTCTHGAFGAFAAGIGTTDLEVGILKGVCAFREPKTIRINLNGSLPEGVYAKD 175
Query: 263 LVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
++L + + G + +EF G V +++ R T+ NM E G T D +++Y
Sbjct: 176 VILHVIGRIGVNGATDRVMEFRGSVVDTMTMESRMTLCNMAIEAGGTSGICMPDMVTVDY 235
Query: 323 LHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
L K++ E+ L A +R ++D V+ +V++ D+ + V+ +P
Sbjct: 236 LWPF--LKDEYQSREAALAAFSLWRS----DEDAVYEQVLDFDVSSLEPIVTFGYKP 286
>UniRef50_Q18GT3 Cluster: 3-isopropylmalate dehydratase large
subunit; n=2; cellular organisms|Rep: 3-isopropylmalate
dehydratase large subunit - Haloquadratum walsbyi
(strain DSM 16790)
Length = 488
Score = 47.2 bits (107), Expect = 8e-04
Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 5/178 (2%)
Query: 208 DSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTI 267
DSHT+ + V+ I+ +V ++ G L+ + D++L I
Sbjct: 131 DSHTSTHGAFGSVGIGIGTSQIRDVLATGCIAAEKQQVRRIEVTGTLSEEVYAKDIILKI 190
Query: 268 TKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEYLHQTN 327
+ L G VG E+ G + L + R V NM E GA + D + EYL
Sbjct: 191 IRDLGVGGGVGHVYEYGGEAIENLDMEGRLAVCNMSIEGGARAGYINPDQTTYEYLKGRE 250
Query: 328 RPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSV 385
+ +D + ++ ++ D D + +VVE++ D+ V+ P VSV
Sbjct: 251 YAPD-VDDWDEHV----EYWDTLRSGDDAEYDDVVEINADDLAPMVTWGINPGQVVSV 303
>UniRef50_A6NVP4 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 396
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 7/141 (4%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G G++HQ L Y G D + DSHT E A M
Sbjct: 95 GEGVIHQ--LMYEKHRANPG-----DLIAIADSHTGTCGGYGVMGVGVGSTELAAAMATG 147
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+ + +P+VV L G+ DL+L + + +V K + F G G+ S+A+R
Sbjct: 148 KLDLEVPQVVQIHLTGKKPANVFGKDLILYLGSVFGTDYLVDKALLFTGEGIEDFSVAER 207
Query: 297 ATVANMCPEFGATLAHFPVDA 317
TV NM E G+ + F A
Sbjct: 208 MTVCNMGIEIGSMITIFGTTA 228
>UniRef50_Q08N42 Cluster: Aconitate hydratase; n=2;
Cystobacterineae|Rep: Aconitate hydratase - Stigmatella
aurantiaca DW4/3-1
Length = 691
Score = 46.0 bits (104), Expect = 0.002
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 4/142 (2%)
Query: 194 FTGPLLHPDSVV-GTDSHTTMINXXXXXXXXXXXIEAEAVM-LGQAISMLLPKVVGYKLV 251
F L+ P VV G DSHT+ + A + LGQ+ + +P+ + +
Sbjct: 151 FYRELVQPGQVVLGADSHTSSHGGLGAFAIGLGGADVTAALVLGQSW-LEVPEAIAVEYQ 209
Query: 252 GELNPLATSTDLVLTITKHL-RSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATL 310
GE D++L L R+ + + VE+ GP V S R T+ANM EFG
Sbjct: 210 GEPPFGIGGKDIILKTLGTLGRNTVALERSVEYRGPAVRGFSTDMRFTIANMTAEFGGLN 269
Query: 311 AHFPVDARSLEYLHQTNRPKEK 332
F D + +L + + K++
Sbjct: 270 GIFEADEAAARWLSRRSSDKDE 291
>UniRef50_O53237 Cluster: 3-isopropylmalate dehydratase large
subunit; n=29; cellular organisms|Rep: 3-isopropylmalate
dehydratase large subunit - Mycobacterium tuberculosis
Length = 473
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/121 (23%), Positives = 52/121 (42%)
Query: 203 SVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTD 262
++V DSHT+ E E V+ Q + + K + + G L ++ D
Sbjct: 130 TIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKD 189
Query: 263 LVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARSLEY 322
++L + + + G G +E+ G + +LS+ R T+ NM E GA D + +
Sbjct: 190 IILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYAF 249
Query: 323 L 323
L
Sbjct: 250 L 250
>UniRef50_A7H0L8 Cluster: 3-isopropylmalate dehydratase, large
subunit; n=1; Campylobacter curvus 525.92|Rep:
3-isopropylmalate dehydratase, large subunit -
Campylobacter curvus 525.92
Length = 421
Score = 45.2 bits (102), Expect = 0.003
Identities = 39/161 (24%), Positives = 62/161 (38%), Gaps = 4/161 (2%)
Query: 196 GPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELN 255
G ++ D ++G DSHT + M+ +P + G+L
Sbjct: 110 GLIVPGDVIIGADSHTCTHGALGAFSTGMGSTDLAYAMITGKNWFKVPPTIKVVFRGKLG 169
Query: 256 PLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPV 315
DL+L I + + G K +EF G + AL + R ++ NM E G V
Sbjct: 170 RHVYGKDLILEIIRQIGVDGARYKALEFCGETIDALDMDGRFSMCNMAIEAGGKSGIIAV 229
Query: 316 DARSLEYLHQTN-RPKEKI---DVIESYLRATKQFRDYTNP 352
D + E+L N R + K D Y R + + D +P
Sbjct: 230 DETTREFLKGKNLRAEPKFFYSDEGAGYERVLEIYADKLDP 270
>UniRef50_A7NXA9 Cluster: Chromosome chr5 scaffold_2, whole genome
shotgun sequence; n=49; Vitis vinifera|Rep: Chromosome
chr5 scaffold_2, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 329
Score = 44.8 bits (101), Expect = 0.004
Identities = 25/51 (49%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Query: 144 NKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVF 194
+K L R ++ F WG AF NM VP SGIV++VNLEYL R VF
Sbjct: 267 HKESALLIQRKRDLLSF-NWGFTAFCNMFDVPLVSGIVYRVNLEYLRRDVF 316
>UniRef50_Q9RTY9 Cluster: 3-isopropylmalate dehydratase large
subunit 1; n=10; Bacteria|Rep: 3-isopropylmalate
dehydratase large subunit 1 - Deinococcus radiodurans
Length = 434
Score = 42.7 bits (96), Expect = 0.017
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 9/132 (6%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G GI HQV +E ++ G + V+G+DSH+T +
Sbjct: 112 GRGICHQVLME--EKLAQPGWI-----VLGSDSHSTTYGAVAAFGSGMGATDIALAAASG 164
Query: 237 AISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADR 296
+ +P+ V L G+L P T+ D+ L + + L + G + VE + +R
Sbjct: 165 KTWLRVPESVKVTLTGDLRPGVTAKDVALEMIRVLGADGATYQSVEIHAGD--RFTRGER 222
Query: 297 ATVANMCPEFGA 308
T+AN+C E GA
Sbjct: 223 MTLANLCVEAGA 234
>UniRef50_Q5PXM8 Cluster: Aconitase A; n=3; Gammaproteobacteria|Rep:
Aconitase A - Vibrio cholerae
Length = 407
Score = 42.3 bits (95), Expect = 0.023
Identities = 39/135 (28%), Positives = 56/135 (41%), Gaps = 10/135 (7%)
Query: 172 LIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEA 231
+ VPP ++HQ Y+ ++ G + ++G+DSHT E
Sbjct: 129 IFVPPHIAVIHQ----YMREMMAGGGKM----ILGSDSHTRY-GALGTMAVGEGGGELVK 179
Query: 232 VMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVV-GKFVEFFGPGVGA 290
+L + P VV L G+ P D+ L I + G V K +EF GPGV A
Sbjct: 180 QLLNDTWDIDYPGVVAVHLTGKPAPYVGPQDVALAIIGAVFKNGYVKNKVMEFVGPGVSA 239
Query: 291 LSIADRATVANMCPE 305
LS R +V M E
Sbjct: 240 LSTDFRNSVDVMTTE 254
>UniRef50_P75764 Cluster: Uncharacterized protein ybhJ; n=32;
Bacteria|Rep: Uncharacterized protein ybhJ - Escherichia
coli (strain K12)
Length = 753
Score = 42.3 bits (95), Expect = 0.023
Identities = 39/135 (28%), Positives = 56/135 (41%), Gaps = 10/135 (7%)
Query: 172 LIVPPGSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEA 231
+ VPP ++HQ Y+ ++ G + ++G+DSHT E
Sbjct: 121 IFVPPHIAVIHQ----YMREMMAGGGKM----ILGSDSHTRY-GALGTMAVGEGGGELVK 171
Query: 232 VMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVV-GKFVEFFGPGVGA 290
+L + P VV L G+ P D+ L I + G V K +EF GPGV A
Sbjct: 172 QLLNDTWDIDYPGVVAVHLTGKPAPYVGPQDVALAIIGAVFKNGYVKNKVMEFVGPGVSA 231
Query: 291 LSIADRATVANMCPE 305
LS R +V M E
Sbjct: 232 LSTDFRNSVDVMTTE 246
>UniRef50_Q8TW29 Cluster: 3-isopropylmalate dehydratase large
subunit 2; n=1; Methanopyrus kandleri|Rep:
3-isopropylmalate dehydratase large subunit 2 -
Methanopyrus kandleri
Length = 402
Score = 42.3 bits (95), Expect = 0.023
Identities = 37/136 (27%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAI 238
G+ HQV L + GP V G DSHT + +L +
Sbjct: 97 GVCHQV----LVEEGYAGP---GRVVFGGDSHTPTSGAASALAFGFGGTDMAFALLYGEL 149
Query: 239 SMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRAT 298
+ +P+ V + GEL AT+ DL LT+ L + +E+ G +S+ DR
Sbjct: 150 WIRVPRTVRVHVEGELEEPATAKDLALTVVGELGAGYADYAVLEYTGL-PERMSLGDRMC 208
Query: 299 VANMCPEFGATLAHFP 314
+ N+ E GA A+ P
Sbjct: 209 LCNLATEAGAKSAYVP 224
>UniRef50_Q6KZ03 Cluster: 3-isopropylmalate dehydratase large
subunit; n=2; Thermoplasmatales|Rep: 3-isopropylmalate
dehydratase large subunit - Picrophilus torridus
Length = 407
Score = 40.3 bits (90), Expect = 0.092
Identities = 43/184 (23%), Positives = 75/184 (40%), Gaps = 25/184 (13%)
Query: 201 PDSVVG-TDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLAT 259
P S++ TDSHT E +V+ ++ + + L +
Sbjct: 110 PGSIIANTDSHTVNTGAYNSLGRGLGTPEIMSVIATGRTWFIVGETINVVFKNYLKSNVS 169
Query: 260 STDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDARS 319
+ D+ + K + S + K +EF G + +L+I DRA+++ MC E A FP D
Sbjct: 170 AKDVFFYMAKTIGS--IPNKNIEFSG-NLKSLTIDDRASISTMCAEMNVEFALFPND--- 223
Query: 320 LEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRP 379
DV+ +Y+ R N D +S+ E+DL +V + V+ P +
Sbjct: 224 --------------DVLRAYM----SNRSLYNVVSDGDYSDQYEIDLNEVQSMVARPGKI 265
Query: 380 QDRV 383
D +
Sbjct: 266 IDNI 269
>UniRef50_UPI00003837C5 Cluster: COG1048: Aconitase A; n=1;
Magnetospirillum magnetotacticum MS-1|Rep: COG1048:
Aconitase A - Magnetospirillum magnetotacticum MS-1
Length = 114
Score = 39.9 bits (89), Expect = 0.12
Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 10 KLLKTIEINGSTYTYYDVSALGPK----YDRLPFSIRVLLESCVRNCDNFQVLEKDVSNV 65
K +T+E G TYTYY + LPFS++V+LE+ +R D+ V + D+
Sbjct: 8 KARRTLEAAGRTYTYYSIPEAQKNGLADAAALPFSMKVILENLLRFEDDRSVKKADIEAA 67
Query: 66 LDWESKQG 73
+ W +G
Sbjct: 68 VAWLGNKG 75
>UniRef50_Q6A800 Cluster: 3-isopropylmalate dehydratase large
subunit; n=1; Propionibacterium acnes|Rep:
3-isopropylmalate dehydratase large subunit -
Propionibacterium acnes
Length = 135
Score = 39.9 bits (89), Expect = 0.12
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 252 GELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLA 311
GE+ T DL+L + + + G G VE+ G + +S+ R T+ NM E+G +
Sbjct: 7 GEVPEEVTPKDLILALISEIGTGGGQGHMVEYRGEAIEKMSMEGRMTICNMSIEWGVRVG 66
Query: 312 HFPVDARSLEYL 323
D + YL
Sbjct: 67 MVASDETTFTYL 78
>UniRef50_Q8U0C0 Cluster: 3-isopropylmalate dehydratase large
subunit 2; n=4; Thermococcaceae|Rep: 3-isopropylmalate
dehydratase large subunit 2 - Pyrococcus furiosus
Length = 380
Score = 39.1 bits (87), Expect = 0.21
Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 12/133 (9%)
Query: 177 GSGIVHQVNLEYLARVVFTGPLLHPDSVVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQ 236
G GI HQ+ VV G + VVG DSHT + + AV+LG
Sbjct: 84 GQGISHQL-------VVEMGLTENSKIVVGADSHTPTLGALGVFAVGMGATDV-AVILGL 135
Query: 237 AISML-LPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIAD 295
+ +P+ VG L G + +TD++L + L+ + + VEFF S+ +
Sbjct: 136 GKTWFRIPESVGVILEGNPSRYVMATDVILHLLSLLKDYDMNYRAVEFFNV---PFSLDE 192
Query: 296 RATVANMCPEFGA 308
R T+ N E A
Sbjct: 193 RLTLTNFVVEANA 205
>UniRef50_Q938C9 Cluster: 3-isopropylmalate dehydratase large
subunit; n=4; Mycobacterium|Rep: 3-isopropylmalate
dehydratase large subunit - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 422
Score = 38.3 bits (85), Expect = 0.37
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 191 RVVFTGPLLHPDSVVG-TDSHTTMINXXXXXXXXXXXIEAEAVML-GQAISMLLPKVVGY 248
+V+ L P ++ TDSHT E +++ GQ P + Y
Sbjct: 100 QVIAENGLARPGEILACTDSHTCAGGAFNTAARGLGPAEVYSILCTGQTWFQASP-TIRY 158
Query: 249 KLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGA 308
+L+G + + D+ L I +E+ GPG+ ++ + DR T+A E A
Sbjct: 159 ELIGSMPAGVSGKDVFLYIADAFGD--ATNSNLEYGGPGLASIPLNDRRTIATQGAEISA 216
Query: 309 TLAHFPVD 316
+ F D
Sbjct: 217 DFSTFAYD 224
>UniRef50_Q97VY2 Cluster: 3-isopropylmalate dehydratase large
subunit; n=10; Thermoprotei|Rep: 3-isopropylmalate
dehydratase large subunit - Sulfolobus solfataricus
Length = 416
Score = 35.9 bits (79), Expect = 2.0
Identities = 43/208 (20%), Positives = 83/208 (39%), Gaps = 13/208 (6%)
Query: 179 GIVHQVNLEYLARVVFTGPLLHPDSVV-GTDSHTTMINXXXXXXXXXXXIEAEAVMLGQA 237
GI+H+V +E A +P V+ DSHTT + A ++
Sbjct: 101 GILHEVMIEQYA---------NPGQVILAADSHTTTSGAVGAFAQGMGASDIAAALITGK 151
Query: 238 ISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFFGPGVGALSIADRA 297
+++P+ L G+ T D+ L + ++ G +E F + + RA
Sbjct: 152 TWLVVPQPFKVVLEGKPAKWITGKDVALKLLGDFKADYFNGMTLEIFVKDPLSFPMDYRA 211
Query: 298 TVANMCPEFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPV 357
TV+NM E A F D + Y+ + + ++ ++ + ++ + E +P+
Sbjct: 212 TVSNMGIEMNADALMFIPDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLD-EMEPL 270
Query: 358 FSEVVELDLGDVVTSVSGPKRPQDRVSV 385
+ +D VV + G P D+V +
Sbjct: 271 VAAPHSVDNVKVVNELEG--TPVDQVYI 296
>UniRef50_Q1Q5P1 Cluster: Similar to NAD(P) oxidoreductase,
FAD-containing subunit; n=1; Candidatus Kuenenia
stuttgartiensis|Rep: Similar to NAD(P) oxidoreductase,
FAD-containing subunit - Candidatus Kuenenia
stuttgartiensis
Length = 581
Score = 35.5 bits (78), Expect = 2.6
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 7/107 (6%)
Query: 66 LDWESKQGNEESVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPDRINPICPAD 125
L WE ++ E V F A V + G ++ MR D G R PI +
Sbjct: 288 LSWEVEEAEHEGVSFHFLAAPVKIVTENGKAKGLECIKMRLGKPDESGRR-RPEPIPDST 346
Query: 126 LVIDHSVQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNML 172
+ID + A+++ DL+F+ +K + KWG A D L
Sbjct: 347 FIIDTDCVIS------AISQEPDLKFLGDKHGLKVNKWGTIAVDGNL 387
>UniRef50_A3UII1 Cluster: Putative 22-domain light-and
oxygen-sensing histidine kinase; n=1; Oceanicaulis
alexandrii HTCC2633|Rep: Putative 22-domain light-and
oxygen-sensing histidine kinase - Oceanicaulis
alexandrii HTCC2633
Length = 700
Score = 35.5 bits (78), Expect = 2.6
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 132 VQVDFARTPDALNKNQDLEFVRNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVN 185
++VD + A K+ D E VRN+E+F+ L A DN++I+ G++ VN
Sbjct: 348 IRVDGEVSYTAFVKDVDAE-VRNREQFKLLSLVADETDNLVIITDAQGLIEYVN 400
>UniRef50_UPI000058674B Cluster: PREDICTED: similar to Tnfaip3-prov
protein; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Tnfaip3-prov protein -
Strongylocentrotus purpuratus
Length = 1187
Score = 35.1 bits (77), Expect = 3.5
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 326 TNRPKEKIDVIESYLR-ATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVS 384
T+ PKE++DV +SYL A ++R YT + +P +E L V+++ S + +
Sbjct: 345 TDHPKEELDVFQSYLNLAEMRYRMYTEEQHNPENAEA--LKAAGVMSATSTQQLNEKMAV 402
Query: 385 VAIMKKDFQDCLTNKPVPIAILSG 408
V+ K+ Q + P A+ +G
Sbjct: 403 VSDPKQPGQPRRVSTEDPSAVQTG 426
>UniRef50_Q4VDG4 Cluster: Putative 3-isopropylmalate dehydratase
large subunit; n=1; Hyaloperonospora parasitica|Rep:
Putative 3-isopropylmalate dehydratase large subunit -
Hyaloperonospora parasitica
Length = 714
Score = 35.1 bits (77), Expect = 3.5
Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 1/115 (0%)
Query: 204 VVGTDSHTTMINXXXXXXXXXXXIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDL 263
++G DSHT + ++ +P+V + VG + D+
Sbjct: 129 IIGADSHTCSAGGMGAFAAGLGAGDVVMPLVTGQTWFKVPEVCYIEFVGAPHFGIGGKDV 188
Query: 264 VLTITKHL-RSLGVVGKFVEFFGPGVGALSIADRATVANMCPEFGATLAHFPVDA 317
+L I L R+ + V + G G+ LS R VANM EFG F DA
Sbjct: 189 ILHILGELKRNTVAFERAVYYGGSGLKFLSDDARFAVANMSTEFGGIAGVFQADA 243
>UniRef50_Q76YZ8 Cluster: Putative uncharacterized protein; n=1;
Aeromonas phage Aeh1|Rep: Putative uncharacterized
protein - Aeromonas phage Aeh1
Length = 399
Score = 35.1 bits (77), Expect = 3.5
Identities = 27/85 (31%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 324 HQTNRPK-EKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDR 382
H P+ E D+I++Y A +F ++ N + FS++ +L L D S+ PK+ D
Sbjct: 31 HWQQMPRYEPKDIIDAY--AEIEF-EFDNNDDVAEFSKLADLPLSDKTKSIWWPKKGPDD 87
Query: 383 VSVAIMKKDFQDCLTNKPVPIAILS 407
SV D+ D L PI I+S
Sbjct: 88 YSVIRYVSDYTD-LNQPKYPIYIVS 111
>UniRef50_Q9ZD92 Cluster: ATP-dependent protease La; n=10;
Rickettsieae|Rep: ATP-dependent protease La - Rickettsia
prowazekii
Length = 784
Score = 34.7 bits (76), Expect = 4.6
Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 2/72 (2%)
Query: 330 KEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSGPKRPQDRVSVAIMK 389
+EK+ + ++YL KQF+ + E + SE LDL T SG R +R A+ +
Sbjct: 496 EEKLQIAKNYL-VPKQFKMHKIKEDEITISEAAILDLIRYYTKESG-VRALEREICALTR 553
Query: 390 KDFQDCLTNKPV 401
K + L NK V
Sbjct: 554 KALKQILANKTV 565
>UniRef50_UPI0000E462A1 Cluster: PREDICTED: similar to LOC495937
protein; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to LOC495937 protein -
Strongylocentrotus purpuratus
Length = 260
Score = 34.3 bits (75), Expect = 6.1
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 21 TYTYYDVSALGPKYDRLPFSIRVLLESCVRNCDNFQVL 58
T+ Y+DV+ G K RL F + + C R C+NF+ L
Sbjct: 125 TFVYFDVTVDGEKIGRLLFEL--FTDQCPRTCENFRAL 160
>UniRef50_A2DTK6 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 601
Score = 34.3 bits (75), Expect = 6.1
Identities = 19/72 (26%), Positives = 40/72 (55%), Gaps = 5/72 (6%)
Query: 315 VDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVS 374
+++ LE N K+ I++++S+ + TK F DYTN E ++ +++ ++ ++ T+ S
Sbjct: 70 IESTKLEIEAIHNEMKDPINILKSFFKKTKDFTDYTNLE---LYKKLI--NISELATTSS 124
Query: 375 GPKRPQDRVSVA 386
QD +A
Sbjct: 125 ENNNNQDMQDMA 136
>UniRef50_A6XPX3 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 319
Score = 34.3 bits (75), Expect = 6.1
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 305 EFGATLAHFPVDARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVEL 364
E GAT + FP + R +YL T R E D +Y + K+ ++ + E++E+
Sbjct: 3 EIGATTSLFPFNDRMYDYLAATKR-TEIGDFARTYAKELKE-------DEGAQYDELIEI 54
Query: 365 DLGDVVTSVSGPKRP 379
+L ++ ++GP P
Sbjct: 55 NLSELEPHINGPFTP 69
>UniRef50_A2F2D5 Cluster: ATPase, AAA family protein; n=1;
Trichomonas vaginalis G3|Rep: ATPase, AAA family protein
- Trichomonas vaginalis G3
Length = 761
Score = 33.9 bits (74), Expect = 8.0
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 316 DARSLEYLHQTNRPKEKIDVIESYLRATKQFRDYTNPEQDPVFSEVVELDLGDVVTSVSG 375
D+ + +Y ++ K+ +D+ + Q + E+DP F EVV+ ++ +V +
Sbjct: 289 DSLAAKYYNRKKLQKKPLDIKHDVILTLAQEIE-NGEEEDPGFDEVVQKNVDALVEAQKK 347
Query: 376 PKRPQDRVSVAIMKKDFQDCLTNKPVPIAILSGVQEHVLD 415
+P+D K D + K P+++LS + ++D
Sbjct: 348 KMQPKDEKKKEEKKPD--NTKKGKDAPVSVLSPSVQKIVD 385
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.137 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 458,256,682
Number of Sequences: 1657284
Number of extensions: 18549932
Number of successful extensions: 41795
Number of sequences better than 10.0: 116
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 41576
Number of HSP's gapped (non-prelim): 133
length of query: 419
length of database: 575,637,011
effective HSP length: 103
effective length of query: 316
effective length of database: 404,936,759
effective search space: 127960015844
effective search space used: 127960015844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 74 (33.9 bits)
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