Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001695-TA|BGIBMGA001695-PA|IPR011682|Glycosyl hydrolases
38, C-terminal, IPR011013|Galactose mutarotase-like
(650 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U68567-1|AAC50812.1| 988|Homo sapiens lysosomal acid alpha-mann... 225 4e-58
U60899-1|AAC51362.1| 1010|Homo sapiens lysosomal alpha-mannosida... 225 4e-58
U60266-1|AAC34130.1| 1011|Homo sapiens lysosomal alpha-mannosida... 225 4e-58
U05572-1|AAB03816.1| 987|Homo sapiens alpha-mannosidase protein. 225 4e-58
BC000736-1|AAH00736.1| 1011|Homo sapiens mannosidase, alpha, cla... 225 4e-58
AB209921-1|BAD93158.1| 1007|Homo sapiens mannosidase, alpha, cla... 225 4e-58
U31520-1|AAC50302.1| 1144|Homo sapiens alpha mannosidase II prot... 83 2e-15
D63998-1|BAA10017.1| 1143|Homo sapiens golgi alpha-mannosidaseII... 83 2e-15
BC094773-1|AAH94773.1| 1009|Homo sapiens mannosidase, alpha, cla... 63 3e-09
BC036836-1|AAH36836.1| 358|Homo sapiens MAN2B2 protein protein. 63 3e-09
BC033307-1|AAH33307.1| 1009|Homo sapiens mannosidase, alpha, cla... 63 3e-09
AL833071-1|CAD89971.1| 1009|Homo sapiens hypothetical protein pr... 63 3e-09
AB023152-1|BAA76779.2| 952|Homo sapiens KIAA0935 protein protein. 63 3e-09
D55649-1|BAA09510.1| 1139|Homo sapiens alpha mannosidase II isoz... 50 2e-05
Z36715-1|CAA85309.1| 407|Homo sapiens Net protein. 33 4.2
L28821-1|AAA92022.1| 796|Homo sapiens alpha mannosidase II isoz... 32 5.5
>U68567-1|AAC50812.1| 988|Homo sapiens lysosomal acid
alpha-mannosidase protein.
Length = 988
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 617 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 674
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 675 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 734
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 735 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 794
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 795 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 852
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 853 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 912
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 913 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 951
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 454 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 513
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 514 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 564
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 420 LQHHDAVSGTSRQHVANDYARQLA 443
>U60899-1|AAC51362.1| 1010|Homo sapiens lysosomal alpha-mannosidase
protein.
Length = 1010
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 639 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 696
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 697 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 756
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 757 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 816
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 817 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 874
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 875 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 934
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 935 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 973
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 476 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 535
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 536 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 586
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 442 LQHHDAVSGTSRQHVANDYARQLA 465
>U60266-1|AAC34130.1| 1011|Homo sapiens lysosomal alpha-mannosidase
protein.
Length = 1011
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 640 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 697
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 698 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 757
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 758 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 817
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 818 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 875
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 876 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 935
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 936 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 974
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 477 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 536
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 537 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 587
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 443 LQHHDAVSGTSRQHVANDYARQLA 466
>U05572-1|AAB03816.1| 987|Homo sapiens alpha-mannosidase protein.
Length = 987
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 616 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 673
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 674 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 733
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 734 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 793
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 794 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 851
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 852 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 911
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 912 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 950
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 453 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 512
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 513 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 563
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 419 LQHHDAVSGTSRQHVANDYARQLA 442
>BC000736-1|AAH00736.1| 1011|Homo sapiens mannosidase, alpha, class
2B, member 1 protein.
Length = 1011
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 640 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 697
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 698 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 757
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 758 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 817
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 818 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 875
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 876 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 935
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 936 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 974
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 477 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 536
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 537 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 587
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 443 LQHHDAVSGTSRQHVANDYARQLA 466
>AB209921-1|BAD93158.1| 1007|Homo sapiens mannosidase, alpha, class
2B, member 1 precursor variant protein.
Length = 1007
Score = 225 bits (550), Expect = 4e-58
Identities = 135/339 (39%), Positives = 189/339 (55%), Gaps = 18/339 (5%)
Query: 273 SFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNV-ESVSEISGDLLSEVRTKIRGNV 331
+F +Y +G+NE ++++SGAYIFRPN K + ++ + + L+ EV
Sbjct: 636 TFFWYNASIGDNE--SDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 693
Query: 332 LSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKL 391
+ R+Y +E EW VGPI V D GKE + ++ T + G FYTDSNGR++L+R+
Sbjct: 694 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRR 753
Query: 392 NARPQWNLTLTEPVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRL 450
+ RP W L TEPV GNYYPV IYI +G + TVLTDRSQGG+SL +G +ELM+HRRL
Sbjct: 754 DYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRL 813
Query: 451 LHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKS---VFQMHLPPVVFVSDAS 507
L DD GV E L E GSG VRG+H +L A Q L P V ++
Sbjct: 814 LKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGG 871
Query: 508 GLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWG-DQILLRIENYKTGAEDS------TI 560
G +Y ++ +P +HLLTL WG + +LLR+E+ EDS +
Sbjct: 872 GAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPV 931
Query: 561 EIDLQGIFNGIHIKSVKETTLAANQWLDDYD--KWTWNT 597
++L+ +F+ I ++ETTL ANQ + KWT NT
Sbjct: 932 TLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNT 970
Score = 44.8 bits (101), Expect = 0.001
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 81 SETFMRLRG-SESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
S RLRG + + +++ + A QV VYNPL V V+LPV+ G +
Sbjct: 473 SNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFV 532
Query: 140 VYAPNGDKIVTQLVEIPDEVKRIPNRRSEA-THELVFIAHLHPLGVKSFYVKRVSTTK 196
V PNG +P +V P+ S+A EL+F A L LG ++ V +V K
Sbjct: 533 VKDPNGR-------TVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWK 583
Score = 40.7 bits (91), Expect = 0.016
Identities = 15/24 (62%), Positives = 21/24 (87%)
Query: 1 MQHHDAITGTEKQHVAHDYERILS 24
+QHHDA++GT +QHVA+DY R L+
Sbjct: 439 LQHHDAVSGTSRQHVANDYARQLA 462
>U31520-1|AAC50302.1| 1144|Homo sapiens alpha mannosidase II
protein.
Length = 1144
Score = 83.4 bits (197), Expect = 2e-15
Identities = 92/363 (25%), Positives = 166/363 (45%), Gaps = 39/363 (10%)
Query: 115 VTVYNPLAWGVREAVKLPVTYGHYEVYAPNGDKIVTQLVEIPDEVKRIPNRRSEATHELV 174
+ VYNPL V + V+ +V++ +G + Q+ + D I SE +E+
Sbjct: 650 LVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTI----SETAYEIS 705
Query: 175 FIAHLHPLGVKSFYVKRVSTTKRAIANGSYLEWISGEGVRSDGYLDRLNQIADVKDLTNL 234
F AH+ PLG+K + + +++ +A+ Y+ + V G I +K++ N
Sbjct: 706 FRAHIPPLGLKVYKILESASSNSHLAD--YV--LYKNKVEDSG-------IFTIKNMINT 754
Query: 235 GLDAIVDEGKEPLWEDANGTGAAFKGTMKKRETDDFKISFAYYPGCLGNNEVPANRSSGA 294
++ L D G T + + + + F++Y + ++ SGA
Sbjct: 755 EEGITLENSFVLLRFDQTGLMKQMM-TKEDGKHHEVNVQFSWYGTTIKRDK------SGA 807
Query: 295 YIFRP--NSTKAIGLNVESVSEISGDLLSEVRTKIRGNVLSIKRVYKEFDFIEHEWLVGP 352
Y+F P N+ + V G + SEV T +V R+Y IE + +
Sbjct: 808 YLFLPDGNAKPYVYTTPPFVRVTHGRIYSEV-TCFFDHVTHRVRLY-HIQGIEGQSVEVS 865
Query: 353 ISVD--DGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE-PVPGNY 409
VD +E +K +DI + FYTD NG Q+ R +TL++ P+ N
Sbjct: 866 NIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPR---------MTLSKLPLQANV 916
Query: 410 YPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLHDDAFGVGEALNETVLG 468
YP+T YI++ + R T+L+ +S G +SL G++E+++ RRL+ DD G+ + + + +
Sbjct: 917 YPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKIT 976
Query: 469 SGL 471
+ L
Sbjct: 977 ANL 979
>D63998-1|BAA10017.1| 1143|Homo sapiens golgi alpha-mannosidaseII
protein.
Length = 1143
Score = 83.4 bits (197), Expect = 2e-15
Identities = 92/363 (25%), Positives = 166/363 (45%), Gaps = 39/363 (10%)
Query: 115 VTVYNPLAWGVREAVKLPVTYGHYEVYAPNGDKIVTQLVEIPDEVKRIPNRRSEATHELV 174
+ VYNPL V + V+ +V++ +G + Q+ + D I SE +E+
Sbjct: 650 LVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTI----SETAYEIS 705
Query: 175 FIAHLHPLGVKSFYVKRVSTTKRAIANGSYLEWISGEGVRSDGYLDRLNQIADVKDLTNL 234
F AH+ PLG+K + + +++ +A+ Y+ + V G I +K++ N
Sbjct: 706 FRAHIPPLGLKVYKILESASSNSHLAD--YV--LYKNKVEDSG-------IFTIKNMINT 754
Query: 235 GLDAIVDEGKEPLWEDANGTGAAFKGTMKKRETDDFKISFAYYPGCLGNNEVPANRSSGA 294
++ L D G T + + + + F++Y + ++ SGA
Sbjct: 755 EEGITLENSFVLLRFDQTGLMKQMM-TKEDGKHHEVNVQFSWYGTTIKRDK------SGA 807
Query: 295 YIFRP--NSTKAIGLNVESVSEISGDLLSEVRTKIRGNVLSIKRVYKEFDFIEHEWLVGP 352
Y+F P N+ + V G + SEV T +V R+Y IE + +
Sbjct: 808 YLFLPDGNAKPYVYTTPPFVRVTHGRIYSEV-TCFFDHVTHRVRLY-HIQGIEGQSVEVS 865
Query: 353 ISVD--DGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE-PVPGNY 409
VD +E +K +DI + FYTD NG Q+ R +TL++ P+ N
Sbjct: 866 NIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPR---------MTLSKLPLQANV 916
Query: 410 YPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLHDDAFGVGEALNETVLG 468
YP+T YI++ + R T+L+ +S G +SL G++E+++ RRL+ DD G+ + + + +
Sbjct: 917 YPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKIT 976
Query: 469 SGL 471
+ L
Sbjct: 977 ANL 979
>BC094773-1|AAH94773.1| 1009|Homo sapiens mannosidase, alpha, class
2B, member 2 protein.
Length = 1009
Score = 63.3 bits (147), Expect = 3e-09
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 13/125 (10%)
Query: 344 IEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE 403
IE E+ GP+ ++ +E V++ T++ + Y+D+NG QM +R + +
Sbjct: 700 IEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSY------VNN 749
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLH--DDAFGVGE 460
+ NYYP+ ++E+G+ R +L++R+ G +S G+VE+MLHRRL + D G
Sbjct: 750 SIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL 809
Query: 461 ALNET 465
LN+T
Sbjct: 810 TLNDT 814
>BC036836-1|AAH36836.1| 358|Homo sapiens MAN2B2 protein protein.
Length = 358
Score = 63.3 bits (147), Expect = 3e-09
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 13/125 (10%)
Query: 344 IEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE 403
IE E+ GP+ ++ +E V++ T++ + Y+D+NG QM +R + +
Sbjct: 49 IEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSY------VNN 98
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLH--DDAFGVGE 460
+ NYYP+ ++E+G+ R +L++R+ G +S G+VE+MLHRRL + D G
Sbjct: 99 SIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL 158
Query: 461 ALNET 465
LN+T
Sbjct: 159 TLNDT 163
>BC033307-1|AAH33307.1| 1009|Homo sapiens mannosidase, alpha, class
2B, member 2 protein.
Length = 1009
Score = 63.3 bits (147), Expect = 3e-09
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 13/125 (10%)
Query: 344 IEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE 403
IE E+ GP+ ++ +E V++ T++ + Y+D+NG QM +R + +
Sbjct: 700 IEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSY------VNN 749
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLH--DDAFGVGE 460
+ NYYP+ ++E+G+ R +L++R+ G +S G+VE+MLHRRL + D G
Sbjct: 750 SIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL 809
Query: 461 ALNET 465
LN+T
Sbjct: 810 TLNDT 814
>AL833071-1|CAD89971.1| 1009|Homo sapiens hypothetical protein
protein.
Length = 1009
Score = 63.3 bits (147), Expect = 3e-09
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 13/125 (10%)
Query: 344 IEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE 403
IE E+ GP+ ++ +E V++ T++ + Y+D+NG QM +R + +
Sbjct: 700 IEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSY------VNN 749
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLH--DDAFGVGE 460
+ NYYP+ ++E+G+ R +L++R+ G +S G+VE+MLHRRL + D G
Sbjct: 750 SIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL 809
Query: 461 ALNET 465
LN+T
Sbjct: 810 TLNDT 814
>AB023152-1|BAA76779.2| 952|Homo sapiens KIAA0935 protein protein.
Length = 952
Score = 63.3 bits (147), Expect = 3e-09
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 13/125 (10%)
Query: 344 IEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTE 403
IE E+ GP+ ++ +E V++ T++ + Y+D+NG QM +R + +
Sbjct: 698 IEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSY------VNN 747
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLH--DDAFGVGE 460
+ NYYP+ ++E+G+ R +L++R+ G +S G+VE+MLHRRL + D G
Sbjct: 748 SIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNL 807
Query: 461 ALNET 465
LN+T
Sbjct: 808 TLNDT 812
>D55649-1|BAA09510.1| 1139|Homo sapiens alpha mannosidase II isozyme
protein.
Length = 1139
Score = 50.4 bits (115), Expect = 2e-05
Identities = 23/62 (37%), Positives = 42/62 (67%), Gaps = 1/62 (1%)
Query: 404 PVPGNYYPVTNEIYIENGE-RFTVLTDRSQGGTSLVEGEVELMLHRRLLHDDAFGVGEAL 462
P+ N+YP+ YI++ + R T+ T ++ G +SL +G++E++L RRL+ DD G+G+ L
Sbjct: 906 PLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGL 965
Query: 463 NE 464
+
Sbjct: 966 KD 967
Score = 32.3 bits (70), Expect = 5.5
Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
Query: 2 QHHDAITGTEKQHVAHDY-ERILSTAID 28
QHHDAITGT K+ V DY R+L + ++
Sbjct: 567 QHHDAITGTAKEAVVVDYGVRLLRSLVN 594
>Z36715-1|CAA85309.1| 407|Homo sapiens Net protein.
Length = 407
Score = 32.7 bits (71), Expect = 4.2
Identities = 33/126 (26%), Positives = 54/126 (42%), Gaps = 4/126 (3%)
Query: 23 LSTAIDDAYSSPDRPSTYDRLNRTTTFSKAAQGDSGKAPLFSYDRCHFNESRCHTSETSE 82
L++++ SS P+ ++ + FS + S K+PL S R F E+ CH S++ E
Sbjct: 214 LASSVSAKISSLMLPNAAS-ISSASPFSSRSPSLSPKSPLPSEHRSLFLEAACHDSDSLE 272
Query: 83 TFMRLRGS--ESGSVVGRI-STKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYE 139
GS +S S+ + K L+ + P VL T +A +T +
Sbjct: 273 PLNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTPAFFT 332
Query: 140 VYAPNG 145
PNG
Sbjct: 333 AQTPNG 338
>L28821-1|AAA92022.1| 796|Homo sapiens alpha mannosidase II isozyme
protein.
Length = 796
Score = 32.3 bits (70), Expect = 5.5
Identities = 15/28 (53%), Positives = 20/28 (71%), Gaps = 1/28 (3%)
Query: 2 QHHDAITGTEKQHVAHDY-ERILSTAID 28
QHHDAITGT K+ V DY R+L + ++
Sbjct: 567 QHHDAITGTAKEAVVVDYGVRLLRSLVN 594
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.135 0.398
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 96,181,454
Number of Sequences: 224733
Number of extensions: 4155782
Number of successful extensions: 7934
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 7833
Number of HSP's gapped (non-prelim): 55
length of query: 650
length of database: 73,234,838
effective HSP length: 95
effective length of query: 555
effective length of database: 51,885,203
effective search space: 28796287665
effective search space used: 28796287665
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 68 (31.5 bits)
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