Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001573-TA|BGIBMGA001573-PA|IPR001128|Cytochrome P450
(496 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 206 1e-52
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 206 1e-52
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 206 1e-52
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 206 1e-52
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 203 1e-51
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 202 2e-51
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 202 2e-51
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 202 2e-51
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 202 2e-51
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 201 4e-51
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 201 4e-51
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 200 7e-51
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 200 9e-51
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 200 9e-51
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 200 9e-51
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 200 9e-51
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 200 9e-51
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 200 9e-51
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 200 9e-51
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 200 1e-50
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 199 2e-50
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 196 1e-49
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 191 4e-48
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 191 6e-48
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 191 6e-48
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 191 6e-48
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 191 6e-48
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 191 6e-48
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 191 6e-48
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 186 1e-46
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 186 1e-46
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 148 5e-35
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 144 8e-34
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 142 2e-33
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 142 3e-33
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 141 4e-33
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 141 4e-33
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 141 4e-33
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 141 4e-33
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 141 4e-33
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 141 4e-33
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 140 1e-32
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 139 2e-32
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 134 9e-31
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 131 5e-30
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 128 6e-29
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 128 6e-29
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 128 6e-29
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 128 6e-29
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 126 2e-28
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 125 3e-28
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 125 3e-28
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 125 3e-28
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 125 3e-28
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 125 3e-28
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 124 5e-28
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 124 5e-28
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 124 5e-28
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 124 1e-27
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 124 1e-27
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 124 1e-27
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 124 1e-27
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 124 1e-27
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 124 1e-27
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 124 1e-27
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 123 1e-27
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 121 5e-27
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 120 9e-27
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 120 9e-27
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 120 9e-27
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 120 9e-27
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 120 9e-27
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 120 1e-26
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 119 2e-26
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 119 2e-26
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 119 2e-26
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 114 6e-25
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 114 6e-25
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 114 6e-25
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 114 6e-25
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 110 1e-23
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 107 7e-23
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 107 7e-23
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 106 2e-22
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 106 2e-22
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 106 2e-22
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 106 2e-22
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 99 4e-20
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 99 4e-20
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 99 4e-20
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 97 9e-20
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 97 9e-20
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 97 9e-20
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 97 9e-20
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 96 2e-19
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 96 3e-19
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 95 7e-19
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 94 9e-19
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 93 3e-18
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 92 4e-18
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 92 4e-18
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 92 4e-18
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 92 4e-18
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 92 4e-18
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 92 4e-18
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 92 4e-18
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 92 4e-18
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 92 4e-18
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 92 4e-18
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 92 4e-18
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 92 4e-18
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 92 4e-18
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 92 4e-18
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 92 4e-18
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 92 4e-18
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 92 4e-18
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 92 4e-18
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 91 6e-18
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 91 6e-18
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 91 1e-17
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 90 1e-17
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 88 6e-17
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 88 6e-17
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 88 6e-17
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 88 6e-17
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 88 6e-17
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 88 6e-17
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 88 6e-17
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 88 6e-17
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 88 6e-17
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 85 5e-16
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 85 5e-16
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 83 2e-15
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 83 2e-15
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 83 2e-15
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 83 2e-15
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 83 3e-15
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 83 3e-15
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 82 5e-15
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 82 5e-15
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 82 5e-15
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 82 5e-15
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 81 7e-15
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 81 7e-15
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 81 1e-14
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 81 1e-14
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 80 2e-14
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 80 2e-14
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 80 2e-14
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 80 2e-14
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 80 2e-14
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 80 2e-14
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 80 2e-14
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 80 2e-14
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 80 2e-14
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 80 2e-14
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 80 2e-14
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 80 2e-14
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 80 2e-14
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 80 2e-14
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 80 2e-14
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 79 5e-14
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 78 6e-14
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 78 6e-14
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 78 6e-14
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 78 6e-14
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 78 6e-14
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 78 6e-14
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 78 6e-14
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 78 6e-14
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 78 8e-14
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 78 8e-14
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 77 1e-13
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 77 1e-13
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 77 2e-13
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 77 2e-13
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 77 2e-13
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 77 2e-13
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 77 2e-13
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 77 2e-13
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 77 2e-13
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 76 3e-13
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 76 3e-13
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 76 3e-13
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 76 3e-13
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 76 3e-13
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 76 3e-13
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 76 3e-13
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 75 4e-13
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 75 4e-13
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 74 1e-12
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 74 1e-12
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 74 1e-12
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 74 1e-12
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 74 1e-12
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 74 1e-12
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 73 2e-12
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 73 2e-12
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 73 2e-12
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 73 2e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 72 5e-12
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 72 5e-12
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 72 5e-12
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 72 5e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 72 5e-12
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 72 5e-12
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 72 5e-12
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 72 5e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 72 5e-12
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 72 5e-12
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 72 5e-12
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 72 5e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 72 5e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 72 5e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 71 7e-12
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 71 9e-12
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 71 1e-11
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 71 1e-11
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 71 1e-11
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 71 1e-11
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 70 2e-11
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 70 2e-11
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 70 2e-11
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 69 3e-11
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 69 3e-11
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 69 3e-11
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 69 3e-11
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 69 3e-11
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 69 4e-11
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 69 4e-11
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 69 4e-11
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 69 4e-11
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 69 5e-11
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 69 5e-11
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 69 5e-11
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 69 5e-11
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 69 5e-11
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 69 5e-11
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 5e-11
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 69 5e-11
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 69 5e-11
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 69 5e-11
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 69 5e-11
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 69 5e-11
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 69 5e-11
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 69 5e-11
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 69 5e-11
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 69 5e-11
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 68 7e-11
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 68 7e-11
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 68 7e-11
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 68 9e-11
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 68 9e-11
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 67 2e-10
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 66 2e-10
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 66 2e-10
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 66 2e-10
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 66 2e-10
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 66 2e-10
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 66 2e-10
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 66 2e-10
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 66 3e-10
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 66 3e-10
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 65 5e-10
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 65 5e-10
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 65 5e-10
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 65 6e-10
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 65 6e-10
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 65 6e-10
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 65 6e-10
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 64 8e-10
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 64 8e-10
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 64 8e-10
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 64 8e-10
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 63 2e-09
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 63 2e-09
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 63 2e-09
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 63 2e-09
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 63 2e-09
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 63 2e-09
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 63 2e-09
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 62 4e-09
M93133-1|AAA58435.1| 504|Homo sapiens cholesterol 7-alpha hydro... 62 4e-09
BC112184-1|AAI12185.1| 504|Homo sapiens cytochrome P450, family... 62 4e-09
BC101777-1|AAI01778.1| 504|Homo sapiens cytochrome P450, family... 62 4e-09
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 62 4e-09
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 62 4e-09
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 62 6e-09
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 62 6e-09
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 62 6e-09
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 61 1e-08
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 61 1e-08
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 61 1e-08
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 60 1e-08
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 60 2e-08
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 60 2e-08
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 60 2e-08
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 59 3e-08
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 59 3e-08
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 59 3e-08
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 59 3e-08
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 59 3e-08
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 59 3e-08
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 59 3e-08
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 59 3e-08
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 58 5e-08
AF176805-1|AAK11850.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 58 7e-08
AF127090-1|AAD20021.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 58 7e-08
BC029155-1|AAH29155.1| 489|Homo sapiens Unknown (protein for IM... 58 9e-08
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 58 9e-08
AF029403-1|AAC95426.1| 506|Homo sapiens oxysterol 7alpha-hydrox... 58 9e-08
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 57 1e-07
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 57 1e-07
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 57 1e-07
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 57 1e-07
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 56 3e-07
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 56 3e-07
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 56 4e-07
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 54 1e-06
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 54 1e-06
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 54 1e-06
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 54 1e-06
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 54 1e-06
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 54 2e-06
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 53 3e-06
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 52 5e-06
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 52 5e-06
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 52 5e-06
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 52 5e-06
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 52 5e-06
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 52 6e-06
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 52 6e-06
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 52 6e-06
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 52 6e-06
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 52 6e-06
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 51 1e-05
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 51 1e-05
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 51 1e-05
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 51 1e-05
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 51 1e-05
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 51 1e-05
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 51 1e-05
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 51 1e-05
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 51 1e-05
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 51 1e-05
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 51 1e-05
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 51 1e-05
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 51 1e-05
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 51 1e-05
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 51 1e-05
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 50 1e-05
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 50 2e-05
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 50 2e-05
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 50 2e-05
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 50 2e-05
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 50 2e-05
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 50 2e-05
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 50 2e-05
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 50 2e-05
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 50 2e-05
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 50 2e-05
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 49 3e-05
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 49 3e-05
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 49 3e-05
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 49 4e-05
M74055-1|AAA36742.1| 229|Homo sapiens thromboxane synthase prot... 48 1e-04
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 48 1e-04
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 48 1e-04
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 48 1e-04
AC004914-2|AAP21887.1| 311|Homo sapiens unknown protein. 48 1e-04
AC004914-1|AAD21788.1| 348|Homo sapiens unknown protein. 48 1e-04
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 47 1e-04
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 47 2e-04
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 47 2e-04
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 47 2e-04
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 45 7e-04
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 45 7e-04
AK127234-1|BAC86895.1| 130|Homo sapiens ). protein. 44 0.001
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 43 0.002
BC067444-1|AAH67444.1| 501|Homo sapiens cytochrome P450, family... 43 0.003
BC067442-1|AAH67442.1| 501|Homo sapiens cytochrome P450, family... 43 0.003
BC067441-1|AAH67441.1| 501|Homo sapiens cytochrome P450, family... 43 0.003
BC067434-1|AAH67434.1| 501|Homo sapiens cytochrome P450, family... 43 0.003
AF090320-1|AAD19877.1| 501|Homo sapiens sterol 12-alpha-hydroxy... 43 0.003
AF090318-1|AAC63037.1| 462|Homo sapiens sterol 12-alpha hydroxy... 43 0.003
AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein. 42 0.004
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 42 0.004
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 40 0.015
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 40 0.027
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 39 0.035
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 36 0.25
D50111-1|BAA08796.1| 46|Homo sapiens CYP2EI protein. 36 0.43
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 34 1.3
D84124-1|BAA28219.1| 509|Homo sapiens prostacyclin synthase pro... 33 2.3
D83402-1|BAA11910.1| 500|Homo sapiens prostacyclin synthase pro... 33 2.3
D38145-1|BAA07343.1| 500|Homo sapiens prostacyclin synthase pro... 33 2.3
BC101811-1|AAI01812.1| 500|Homo sapiens prostaglandin I2 (prost... 33 2.3
BC101809-1|AAI01810.1| 500|Homo sapiens prostaglandin I2 (prost... 33 2.3
AL118525-1|CAC14162.1| 500|Homo sapiens prostaglandin I2 (prost... 33 2.3
AF297051-1|AAG31784.1| 500|Homo sapiens prostacyclin synthase p... 33 2.3
AF297050-1|AAG31783.1| 500|Homo sapiens prostacyclin synthase p... 33 2.3
AF297049-1|AAG31782.1| 500|Homo sapiens prostacyclin synthase p... 33 2.3
AF297048-1|AAG31781.1| 500|Homo sapiens prostacyclin synthase p... 33 2.3
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 33 3.1
AF297052-1|AAG31785.1| 500|Homo sapiens prostacyclin synthase p... 32 4.0
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 31 7.0
BC035162-1|AAH35162.3| 1300|Homo sapiens ATPase, Class I, type 8... 31 7.0
AF280107-4|AAG32288.1| 106|Homo sapiens cytochrome P450 polypep... 31 7.0
AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega hy... 31 9.3
AC005336-2|AAC27731.1| 93|Homo sapiens F20191_1, partial CDS p... 31 9.3
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 206 bits (504), Expect = 1e-52
Identities = 142/470 (30%), Positives = 234/470 (49%), Gaps = 25/470 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P L GN+ R+ + E Y +Y K+ G + P L + D D+++
Sbjct: 38 IPGPTPLPLLGNV---LSYRQGLWKFDTECYKKYG--KMWGTYEGQLPVLAITDPDVIRT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQT 151
+++K+ Y+ F R + + A+ + WK +RS L+P F+SGKLK M +++Q
Sbjct: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEMLN 204
GD V ++ E L +F Y++ I SF + D +N+ Q + L
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212
Query: 205 VAVFENSYISELDMVF-PGILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
+ ++S + F + N S+F NF + V +K R N K +R D +
Sbjct: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ +A Q +F AGY + L+F+LY LA +
Sbjct: 273 QLMI----DSQNSKE-TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
Q++L +EI+ VL N T +A+ +M YL+M+ ETLR+ P L+R+ +D I G
Sbjct: 328 QQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING- 385
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG++V+IP A HHD K + EPE+F PERFS + S + FG GPR CIG
Sbjct: 386 -VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIG 443
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
+R A + K+ +++ L + P T+ K+D + L+PE + + +
Sbjct: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 492
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 206 bits (504), Expect = 1e-52
Identities = 142/470 (30%), Positives = 234/470 (49%), Gaps = 25/470 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P L GN+ R+ + E Y +Y K+ G + P L + D D+++
Sbjct: 38 IPGPTPLPLLGNV---LSYRQGLWKFDTECYKKYG--KMWGTYEGQLPVLAITDPDVIRT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQT 151
+++K+ Y+ F R + + A+ + WK +RS L+P F+SGKLK M +++Q
Sbjct: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEMLN 204
GD V ++ E L +F Y++ I SF + D +N+ Q + L
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212
Query: 205 VAVFENSYISELDMVF-PGILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
+ ++S + F + N S+F NF + V +K R N K +R D +
Sbjct: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ +A Q +F AGY + L+F+LY LA +
Sbjct: 273 QLMI----DSQNSKE-TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
Q++L +EI+ VL N T +A+ +M YL+M+ ETLR+ P L+R+ +D I G
Sbjct: 328 QQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING- 385
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG++V+IP A HHD K + EPE+F PERFS + S + FG GPR CIG
Sbjct: 386 -VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIG 443
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
+R A + K+ +++ L + P T+ K+D + L+PE + + +
Sbjct: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 492
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 206 bits (504), Expect = 1e-52
Identities = 142/470 (30%), Positives = 234/470 (49%), Gaps = 25/470 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P L GN+ R+ + E Y +Y K+ G + P L + D D+++
Sbjct: 38 IPGPTPLPLLGNV---LSYRQGLWKFDTECYKKYG--KMWGTYEGQLPVLAITDPDVIRT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQT 151
+++K+ Y+ F R + + A+ + WK +RS L+P F+SGKLK M +++Q
Sbjct: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEMLN 204
GD V ++ E L +F Y++ I SF + D +N+ Q + L
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212
Query: 205 VAVFENSYISELDMVF-PGILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
+ ++S + F + N S+F NF + V +K R N K +R D +
Sbjct: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ +A Q +F AGY + L+F+LY LA +
Sbjct: 273 QLMI----DSQNSKE-TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
Q++L +EI+ VL N T +A+ +M YL+M+ ETLR+ P L+R+ +D I G
Sbjct: 328 QQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING- 385
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG++V+IP A HHD K + EPE+F PERFS + S + FG GPR CIG
Sbjct: 386 -VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIG 443
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
+R A + K+ +++ L + P T+ K+D + L+PE + + +
Sbjct: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 492
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 206 bits (503), Expect = 1e-52
Identities = 141/470 (30%), Positives = 234/470 (49%), Gaps = 25/470 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P L GN+ R+ + E Y +Y K+ G + P L + D D+++
Sbjct: 38 IPGPTPLPLLGNV---LSYRQGLWKFDTECYKKYG--KMWGTYEGQLPVLAITDPDVIRT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQT 151
+++K+ Y+ F R + + A+ + WK +R L+P F+SGKLK M +++Q
Sbjct: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRPLLSPTFTSGKLKEMFPIIAQY 152
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEMLN 204
GD V ++ E L +F Y++ I SF + D +N+ Q + L
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212
Query: 205 VAVFENSYISELDMVF-PGILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
+ ++S + F + N S+F NF + V +K R N K +R D +
Sbjct: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ +A Q +F AGY + L+F+LY LA +
Sbjct: 273 QLMI----DSQNSKE-TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
Q++L +EI+ VL N T +A+ +M YL+M+ ETLR+ P L+R+ ++D I G
Sbjct: 328 QQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCMKDVEING- 385
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG++V+IP A HHD K + EPE+F PERFS + S + FG GPR CIG
Sbjct: 386 -VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIG 443
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
+R A + K+ +++ L + P T+ K+D + L+PE + + +
Sbjct: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 492
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 203 bits (496), Expect = 1e-51
Identities = 148/473 (31%), Positives = 232/473 (49%), Gaps = 25/473 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVCGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ---VYEMLNVA 206
GD V ++ E L +F Y++ I + SF + D +N+ Q V +
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 207 VFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
F+ L ++FP IL N +F V NF + V+ +K R +R D +
Sbjct: 212 RFDFLDPFFLSIIFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL 271
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ + Q +F AGY + L+F +Y LA +
Sbjct: 272 QLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDV 326
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I G
Sbjct: 327 QQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING- 384
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR CIG
Sbjct: 385 -MFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRNCIG 443
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 495
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 202 bits (494), Expect = 2e-51
Identities = 147/455 (32%), Positives = 229/455 (50%), Gaps = 27/455 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN SF RK T E Y +Y KV G++ P L + D D++K
Sbjct: 38 IPGPTPLPFLGNAL-SF--RKGYWTFDMECYKKY--RKVWGIYDCQQPMLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G N A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ---VYEMLNVA 206
GD V ++ E L +F Y++ I + SF + D +N+ Q V +
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL 211
Query: 207 VFE--NSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRND 260
F + ++ + VFP IL N ++F V +F + V+ IK R +R D
Sbjct: 212 RFNPLDPFVLSIK-VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD 270
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
+ +++ D K+ SE +++ + Q +F AGY + L+F +Y LA
Sbjct: 271 FLQLMI----DSQNSKD-SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHP 325
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIP 380
+Q+++ +EI+TVL N T + + ++ YL+M+ ETLR+ P L+R +D I
Sbjct: 326 DVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEIN 384
Query: 381 GTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTC 440
G + I KG +V+IP HHD K + EPEKF PERFS +N + + FG GPR C
Sbjct: 385 G--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
Query: 441 IGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
IG+R A + K+ +V+ L + P T+ K+
Sbjct: 443 IGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 202 bits (494), Expect = 2e-51
Identities = 147/455 (32%), Positives = 229/455 (50%), Gaps = 27/455 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN SF RK T E Y +Y KV G++ P L + D D++K
Sbjct: 38 IPGPTPLPFLGNAL-SF--RKGYWTFDMECYKKY--RKVWGIYDCQQPMLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G N A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ---VYEMLNVA 206
GD V ++ E L +F Y++ I + SF + D +N+ Q V +
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL 211
Query: 207 VFE--NSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRND 260
F + ++ + VFP IL N ++F V +F + V+ IK R +R D
Sbjct: 212 RFNPLDPFVLSIK-VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD 270
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
+ +++ D K+ SE +++ + Q +F AGY + L+F +Y LA
Sbjct: 271 FLQLMI----DSQNSKD-SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHP 325
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIP 380
+Q+++ +EI+TVL N T + + ++ YL+M+ ETLR+ P L+R +D I
Sbjct: 326 DVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEIN 384
Query: 381 GTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTC 440
G + I KG +V+IP HHD K + EPEKF PERFS +N + + FG GPR C
Sbjct: 385 G--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
Query: 441 IGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
IG+R A + K+ +V+ L + P T+ K+
Sbjct: 443 IGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 202 bits (494), Expect = 2e-51
Identities = 147/455 (32%), Positives = 229/455 (50%), Gaps = 27/455 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN SF RK T E Y +Y KV G++ P L + D D++K
Sbjct: 38 IPGPTPLPFLGNAL-SF--RKGYWTFDMECYKKY--RKVWGIYDCQQPMLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G N A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ---VYEMLNVA 206
GD V ++ E L +F Y++ I + SF + D +N+ Q V +
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL 211
Query: 207 VFE--NSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRND 260
F + ++ + VFP IL N ++F V +F + V+ IK R +R D
Sbjct: 212 RFNPLDPFVLSIK-VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD 270
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
+ +++ D K+ SE +++ + Q +F AGY + L+F +Y LA
Sbjct: 271 FLQLMI----DSQNSKD-SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHP 325
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIP 380
+Q+++ +EI+TVL N T + + ++ YL+M+ ETLR+ P L+R +D I
Sbjct: 326 DVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEIN 384
Query: 381 GTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTC 440
G + I KG +V+IP HHD K + EPEKF PERFS +N + + FG GPR C
Sbjct: 385 G--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
Query: 441 IGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
IG+R A + K+ +V+ L + P T+ K+
Sbjct: 443 IGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 202 bits (494), Expect = 2e-51
Identities = 147/455 (32%), Positives = 229/455 (50%), Gaps = 27/455 (5%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN SF RK T E Y +Y KV G++ P L + D D++K
Sbjct: 38 IPGPTPLPFLGNAL-SF--RKGYWTFDMECYKKY--RKVWGIYDCQQPMLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G N A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ---VYEMLNVA 206
GD V ++ E L +F Y++ I + SF + D +N+ Q V +
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL 211
Query: 207 VFE--NSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRND 260
F + ++ + VFP IL N ++F V +F + V+ IK R +R D
Sbjct: 212 RFNPLDPFVLSIK-VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD 270
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
+ +++ D K+ SE +++ + Q +F AGY + L+F +Y LA
Sbjct: 271 FLQLMI----DSQNSKD-SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHP 325
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIP 380
+Q+++ +EI+TVL N T + + ++ YL+M+ ETLR+ P L+R +D I
Sbjct: 326 DVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEIN 384
Query: 381 GTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTC 440
G + I KG +V+IP HHD K + EPEKF PERFS +N + + FG GPR C
Sbjct: 385 G--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
Query: 441 IGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
IG+R A + K+ +V+ L + P T+ K+
Sbjct: 443 IGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 201 bits (491), Expect = 4e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 29/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKL 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRE-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLNNPQDPLVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKAVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 325
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 326 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 384
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 385 NG--MFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 442
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 443 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 497
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 201 bits (491), Expect = 4e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 29/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKL 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRE-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLNNPQDPLVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKAVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 325
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 326 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 384
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 385 NG--MFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 442
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 443 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 497
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 200 bits (489), Expect = 7e-51
Identities = 151/498 (30%), Positives = 239/498 (47%), Gaps = 30/498 (6%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P GN+ S+H K E + +Y K
Sbjct: 16 ATSLVLLYIYGTHSHGLFKKLGIPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--K 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAV 128
V G + P L + D D++K +++K+ Y+ F R F G + A+ + WK +
Sbjct: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRL 129
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
RS L+P F+SGKLK MV +++Q GD V ++ E L +F Y++ I + SF
Sbjct: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189
Query: 189 SMETD-INDMQ------VYEMLNVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNN 238
+ D +N+ Q ++L + ++S VFP IL N +F V N
Sbjct: 190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTN 247
Query: 239 FCYEIVEFIKNER-NGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVF 297
F + V+ +K R +R D + +++ D K +E +++ + Q +F
Sbjct: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIF 302
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
AGY + L+F +Y LA +Q++L EI+ VL N T + + +M YL+M+
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVN 361
Query: 358 ETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF 417
ETLR+ P L+R +D I G + I KG +V+IP A H D K + EPEKF PERF
Sbjct: 362 ETLRLFPIAMRLERVCKKDVEING--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDP 477
S +N + + FG GPR CIG+R A + K+ +++ L + P T+ K+
Sbjct: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS- 478
Query: 478 LRTALEPEGGVYVDILPR 495
L L+PE V + + R
Sbjct: 479 LGGLLQPEKPVVLKVESR 496
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 200 bits (488), Expect = 9e-51
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 200 bits (487), Expect = 1e-50
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 199 bits (486), Expect = 2e-50
Identities = 148/476 (31%), Positives = 233/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AGY + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 196 bits (479), Expect = 1e-49
Identities = 147/476 (30%), Positives = 232/476 (48%), Gaps = 30/476 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P GN+ S+H K E + +Y KV G + P L + D D++K
Sbjct: 38 IPGPTPLPFLGNIL-SYH--KGFCMFDMECHKKYG--KVWGFYDGQQPVLAITDPDMIKT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFSSGKLKNMVRVLSQ 150
+++K+ Y+ F R F G + A+ + WK +RS L+P F+SGKLK MV +++Q
Sbjct: 93 VLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151
Query: 151 TGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEML 203
GD V ++ E L +F Y++ I + SF + D +N+ Q ++L
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211
Query: 204 NVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRN 259
+ ++S VFP IL N +F V NF + V+ +K R +R
Sbjct: 212 RFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D + +++ D K +E +++ + Q +F AG + L+F +Y LA
Sbjct: 270 DFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATH 324
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
+Q++L EI+ VL N T + + +M YL+M+ ETLR+ P L+R +D I
Sbjct: 325 PDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G + I KG +V+IP A H D K + EPEKF PERFS +N + + FG GPR
Sbjct: 384 NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
CIG+R A + K+ +++ L + P T+ K+ L L+PE V + + R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 496
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 191 bits (466), Expect = 4e-48
Identities = 134/429 (31%), Positives = 214/429 (49%), Gaps = 25/429 (5%)
Query: 80 PTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFH-ADADAWKAVRSHLTPMFS 137
P L + D D++K +++K+ Y+ F R F G + A+ + WK +RS L+P F+
Sbjct: 7 PVLAITDPDMIKTVLVKECYSVFTNRR-PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFT 65
Query: 138 SGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-IND 196
SGKLK MV +++Q GD V ++ E L +F Y++ I + SF + D +N+
Sbjct: 66 SGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNN 125
Query: 197 MQ------VYEMLNVAVFENSYISELDMVFP---GILRKTNRSIFGPTVNNFCYEIVEFI 247
Q ++L + ++S VFP IL N +F V NF + V+ +
Sbjct: 126 PQDPFVENTKKLLRFDFLDPFFLSIT--VFPFLIPILEVLNICVFPREVTNFLRKSVKRM 183
Query: 248 KNER-NGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNT 306
K R +R D + +++ D K +E +++ + Q +F AGY +
Sbjct: 184 KESRLEDTQKHRVDFLQLMI----DSQNSKE-TESHKALSDLELVAQSIIFIFAGYETTS 238
Query: 307 ITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTT 366
L+F +Y LA +Q++L EI+ VL N T + + +M YL+M+ ETLR+ P
Sbjct: 239 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIA 297
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
L+R +D I G + I KG +V+IP A H D K + EPEKF PERFS +N +
Sbjct: 298 MRLERVCKKDVEING--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 355
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEG 486
+ FG GPR CIG+R A + K+ +++ L + P T+ K+ L L+PE
Sbjct: 356 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEK 414
Query: 487 GVYVDILPR 495
V + + R
Sbjct: 415 PVVLKVESR 423
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 191 bits (465), Expect = 6e-48
Identities = 142/493 (28%), Positives = 232/493 (47%), Gaps = 26/493 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNVA-VFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PERFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL- 480
Query: 480 TALEPEGGVYVDI 492
L+PE + + +
Sbjct: 481 PILQPEKPIVLKV 493
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 186 bits (454), Expect = 1e-46
Identities = 142/494 (28%), Positives = 232/494 (46%), Gaps = 27/494 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNV-AVFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPE-RFS 418
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PE RFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPL 478
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481
Query: 479 RTALEPEGGVYVDI 492
L+PE + + +
Sbjct: 482 -PILQPEKPIVLKV 494
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 186 bits (454), Expect = 1e-46
Identities = 142/494 (28%), Positives = 232/494 (46%), Gaps = 27/494 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNV-AVFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPE-RFS 418
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PE RFS
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPL 478
+N S ++ FG GPR CIG+R A K+ +++ L + P T+ K+D L
Sbjct: 422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481
Query: 479 RTALEPEGGVYVDI 492
L+PE + + +
Sbjct: 482 -PILQPEKPIVLKV 494
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 148 bits (358), Expect = 5e-35
Identities = 118/417 (28%), Positives = 193/417 (46%), Gaps = 25/417 (5%)
Query: 11 ASIVVLIXXXXXXXXXXXXXXXIAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEK 70
A+ +VL+ I GP P G + F+ R + +E ++Y +
Sbjct: 16 ATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL--FYLRG-LWNFDRECNEKYGE-- 70
Query: 71 VVGMFRMTSPTLIVRDLDIVKQIMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVR 129
+ G++ P L++ D D++K +++K+ Y+ F + L L A+ + WK +R
Sbjct: 71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIR 130
Query: 130 SHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS 189
+ L+P F+S K K MV ++SQ GD V + E L F Y + I F
Sbjct: 131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190
Query: 190 METD-INDMQVYEMLNV-AVFENSYISE---LDMVFP---GILRKTNRSIFGPTVNNFCY 241
+ D +N+ Q + N+ + + ++ L +FP + N +F V +F
Sbjct: 191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLK 250
Query: 242 EIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFA 299
+E +K R K +R D ++ N + K D ++A + + FA
Sbjct: 251 NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDL-----ELVAQSIIIIFA 305
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
A Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +M YL+M+ ET
Sbjct: 306 A-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQMEYLDMVVNET 363
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPER 416
LR+ P + + R +D I G + I KG V++P A HHD K + EPEKF PER
Sbjct: 364 LRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 144 bits (348), Expect = 8e-34
Identities = 89/272 (32%), Positives = 136/272 (50%), Gaps = 12/272 (4%)
Query: 223 ILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMMDMLL-GVNCDKLKMKNGSE 280
+ N +F V +F +E +K R K +R D ++ N + K
Sbjct: 122 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALS 181
Query: 281 DFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV 340
D ++A + + FAA Y + TL F +Y LA +Q++L EI+ VL N V
Sbjct: 182 DL-----ELVAQSIIIIFAA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV 235
Query: 341 LTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFH 400
T +A+ +M YL+M+ ETLR+ P + + R +D I G + I KG V++P A H
Sbjct: 236 -TYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALH 292
Query: 401 HDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTK 460
HD K + EPEKF PERFS +N S ++ FG GPR CIG+R A K+ +++ L
Sbjct: 293 HDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQN 352
Query: 461 YRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
+ P T+ K+D L L+PE + + +
Sbjct: 353 FSFKPCKETQIPLKLDNL-PILQPEKPIVLKV 383
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 142 bits (345), Expect = 2e-33
Identities = 75/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A ED + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 142 bits (343), Expect = 3e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPENFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 48.4 bits (110), Expect = 6e-05
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + +F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVD 201
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 259 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 318
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 319 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 376
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 377 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 436
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 437 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 466
Score = 48.4 bits (110), Expect = 6e-05
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 21 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 78
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + +F D
Sbjct: 79 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVD 133
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 48.4 bits (110), Expect = 6e-05
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + +F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVD 201
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 141 bits (342), Expect = 4e-33
Identities = 89/274 (32%), Positives = 138/274 (50%), Gaps = 10/274 (3%)
Query: 223 ILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMMDMLLGVNCDKLKMKNGSED 281
IL N +F V NF + V+ +K R +R D + +++ D K +E
Sbjct: 82 ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI----DSQNSKE-TES 136
Query: 282 FVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL 341
+++ + Q +F AGY + L+F +Y LA +Q++L EI+ VL N
Sbjct: 137 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP- 195
Query: 342 TLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHH 401
T + + +M YL+M+ ETLR+ P L+R +D I G + I KG +V+IP A H
Sbjct: 196 TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING--MFIPKGVVVMIPSYALHR 253
Query: 402 DEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
D K + EPEKF PERFS +N + + FG GPR CIG+R A + K+ +++ L +
Sbjct: 254 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 313
Query: 462 RVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
P T+ K+ L L+PE V + + R
Sbjct: 314 SFKPCKETQIPLKLS-LGGLLQPEKPVVLKVESR 346
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 46.0 bits (104), Expect = 3e-04
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ + + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACELLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 141 bits (342), Expect = 4e-33
Identities = 74/211 (35%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 140 bits (338), Expect = 1e-32
Identities = 73/211 (34%), Positives = 116/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P P+ F+PERF+ E + +L FG GPR+C+G+RL L+ K+ ++ L K+R
Sbjct: 445 HWPSPKTFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 505 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 534
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 139 bits (337), Expect = 2e-32
Identities = 73/211 (34%), Positives = 115/211 (54%), Gaps = 3/211 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 326 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 385
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 386 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 443
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+P PE F+PERF+ E + +L FG GPR+C+G+ L L+ K+ ++ L K+R
Sbjct: 444 HWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQ 503
Query: 465 PSTRTKDAYKIDPLRTALEPEGGVYVDILPR 495
T+ +++ ++AL P+ GVY+ I+ R
Sbjct: 504 ACPETQVPLQLES-KSALGPKNGVYIKIVSR 533
Score = 48.4 bits (110), Expect = 6e-05
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 88 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 145
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + +F D
Sbjct: 146 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVD 200
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 134 bits (323), Expect = 9e-31
Identities = 111/435 (25%), Positives = 200/435 (45%), Gaps = 29/435 (6%)
Query: 78 TSPTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPM 135
T P LI+ DI++ I A + I F K LGD L + D W R LTP
Sbjct: 95 TFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPA 154
Query: 136 FSSGKLKNMVRVLSQTGDRFVD---HVTNEVRLRPEQ-ELVSLFLKYNIATIMACSFSME 191
F LK +++ +++ + D + +E R + E +SL + ++ C FS E
Sbjct: 155 FHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLM---TLDSLQKCVFSFE 211
Query: 192 TDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEF-- 246
++ + + +L ++ F ++ ++ L G C+ + +F
Sbjct: 212 SNCQEKPSEYIAAILELSAFVEKRNQQI-LLHTDFLYYLTPD--GQRFRRACHLVHDFTD 268
Query: 247 --IKNERNGKPANRND--MMDMLLGVNCDKLK--MKNGSEDFVEITEHVMAGQVFVFFAA 300
I+ R P D + + D + + + ED E+++ + + F
Sbjct: 269 AVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFE 328
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV-LTLEAINEMSYLEMIFLET 359
G+ L++ LYHLAK QE+ +E++ +L++ + + + + ++ +L M E+
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKES 388
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+HP + R +D+ +P + I KG + LI + H++ ++P+PE +DP RF+
Sbjct: 389 LRLHPPVPVISRCCTQDFVLPDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQ 447
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
EN K R AF+ F GPR CIG A + KV + L +R+ P T T+ K + +
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP-THTEPRRKPELI- 505
Query: 480 TALEPEGGVYVDILP 494
L EGG+++ + P
Sbjct: 506 --LRAEGGLWLRVEP 518
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 131 bits (317), Expect = 5e-30
Identities = 110/435 (25%), Positives = 199/435 (45%), Gaps = 29/435 (6%)
Query: 78 TSPTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPM 135
T P LI+ DI++ I A + I F K LGD L + D W R LTP
Sbjct: 95 TFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPA 154
Query: 136 FSSGKLKNMVRVLSQTGDRFVD---HVTNEVRLRPEQ-ELVSLFLKYNIATIMACSFSME 191
F LK +++ +++ + D + +E R + E +SL + ++ C FS E
Sbjct: 155 FHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLM---TLDSLQKCVFSFE 211
Query: 192 TDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEF-- 246
++ + + +L ++ F ++ ++ L G C+ + +F
Sbjct: 212 SNCQEKPSEYIAAILELSAFVEKRNQQI-LLHTDFLYYLTPD--GQRFRRACHLVHDFTD 268
Query: 247 --IKNERNGKPANRND--MMDMLLGVNCDKLK--MKNGSEDFVEITEHVMAGQVFVFFAA 300
I+ R P D + + D + + + ED E+++ + + F
Sbjct: 269 AVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFE 328
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV-LTLEAINEMSYLEMIFLET 359
G+ L++ LYHLAK QE+ +E++ +L++ + + + + ++ +L M E+
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKES 388
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+HP + R +D+ +P + I KG + LI + H++ ++P+PE +DP RF+
Sbjct: 389 LRLHPPVPVISRCCTQDFVLPDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQ 447
Query: 420 ENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLR 479
EN K R AF+ F GPR CIG A + KV + L +R+ P T + K + +
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP-THIEPRRKPELI- 505
Query: 480 TALEPEGGVYVDILP 494
L EGG+++ + P
Sbjct: 506 --LRAEGGLWLRVEP 518
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 128 bits (308), Expect = 6e-29
Identities = 98/402 (24%), Positives = 178/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 125 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 184
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
R + E +SL + ++ C FS ++ + + + +
Sbjct: 185 GSSRLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 420
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 481 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 518
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 128 bits (308), Expect = 6e-29
Identities = 98/402 (24%), Positives = 178/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 125 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 184
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
R + E +SL + ++ C FS ++ + + + +
Sbjct: 185 GSSRLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 420
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 481 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 518
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 128 bits (308), Expect = 6e-29
Identities = 98/402 (24%), Positives = 178/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 125 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 184
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
R + E +SL + ++ C FS ++ + + + +
Sbjct: 185 GSSRLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 420
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 481 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 518
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 128 bits (308), Expect = 6e-29
Identities = 98/402 (24%), Positives = 178/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 125 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 184
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
R + E +SL + ++ C FS ++ + + + +
Sbjct: 185 GSSRLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 420
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 481 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 518
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 126 bits (303), Expect = 2e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 125 bits (302), Expect = 3e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 125 bits (302), Expect = 3e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 125 bits (302), Expect = 3e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 125 bits (302), Expect = 3e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 125 bits (302), Expect = 3e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 124 bits (300), Expect = 5e-28
Identities = 97/402 (24%), Positives = 177/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 125 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 184
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
+ E +SL + ++ C FS ++ + + + +
Sbjct: 185 GSSCLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 241
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 242 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 301
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 362 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 420
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 481 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 518
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 124 bits (300), Expect = 5e-28
Identities = 97/402 (24%), Positives = 177/402 (44%), Gaps = 21/402 (5%)
Query: 106 IKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVD---HVTNE 162
I+F K LG+ + + D W R LTP F LK+ + + +++ + +D H+ +E
Sbjct: 59 IRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE 118
Query: 163 VRLRPEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFP 221
+ E +SL + ++ C FS ++ + + + +
Sbjct: 119 GSSCLDMFEHISLM---TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQ 175
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRND--MMDMLLGVNCDKLK- 274
+ S G + C + +F I+ R P D D D +
Sbjct: 176 HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV 235
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ + ED +++ + + F G+ L++ LY+LA+ QER +E++ +
Sbjct: 236 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 295
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
L++ + + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 296 LKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITC 354
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
LI + HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV
Sbjct: 355 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 414
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L +R P T+ K++ + A EGG+++ + P
Sbjct: 415 VLALMLLHFRFLPD-HTEPRRKLELIMRA---EGGLWLRVEP 452
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 124 bits (300), Expect = 5e-28
Identities = 112/458 (24%), Positives = 200/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ +++ + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 124 bits (298), Expect = 1e-27
Identities = 112/458 (24%), Positives = 199/458 (43%), Gaps = 32/458 (6%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKD--YAKFNERGIKFSKEGLGD 115
V ++ YP V M + SP L + DI++ ++ A ++ F + LGD
Sbjct: 76 VLTQLVATYPQGFKVWMGPI-SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L + D W R LTP F LK +++ + + + + H ++ + +F
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNDSVN--IMHAKWQLLASEGSACLDMF 192
Query: 176 LKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNR 229
++ T+ C FS ++ + + +L ++ + E+ + + T
Sbjct: 193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPD 252
Query: 230 SIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGS 279
G C + +F I+ R P+ D D L K + + +
Sbjct: 253 ---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKD 307
Query: 280 EDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
ED ++++ + + F G+ L++ LYHLAK QER +E++ +L++
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + + +L M E+LR+HP + R +D +P + I KG + LI
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKGIICLISVFG 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN K R AF+ F GPR CIG A + KV + L
Sbjct: 427 THHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
++RV P T+ K + L EGG+++ + P S
Sbjct: 487 LRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 115 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 293
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 294 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 345
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 346 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 403
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 404 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 463
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 464 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 503
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 115 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 293
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 294 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 345
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 346 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 403
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 404 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 463
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 464 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 503
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 115 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 293
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 294 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 345
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 346 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 403
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 404 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 463
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 464 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 503
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 115 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 293
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 294 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 345
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 346 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 403
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 404 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 463
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 464 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 503
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 115 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 174
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 175 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 234
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 293
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 294 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 345
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 346 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 403
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 404 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 463
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 464 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 503
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 124 bits (298), Expect = 1e-27
Identities = 106/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 50 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 109
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ IM C+FS ET+ ++ A+FE S I
Sbjct: 110 DTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 169
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 170 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 228
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 229 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 280
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 281 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 338
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 339 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 398
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 399 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 438
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 123 bits (297), Expect = 1e-27
Identities = 105/403 (26%), Positives = 174/403 (43%), Gaps = 31/403 (7%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KFS LG L D W R LTP F LK + V++ + +D +
Sbjct: 114 KFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQ 173
Query: 167 PEQ-ELVSLFLKYNIATIMACSFSMETDINDMQVYEMLNVAVFENSYIS---------EL 216
E+ ++ +M C+FS ET+ ++ A+FE S I
Sbjct: 174 DTSVEVYEHINSMSLDIVMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHS 233
Query: 217 DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN------ERNGKPANR-NDMMDMLLGVN 269
D++F + +N + I++ K +++ P + D +D++L
Sbjct: 234 DIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSA- 292
Query: 270 CDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMRE 329
K ++GS F +I H +V F AG+ ++++ LY LA + QER E
Sbjct: 293 ----KDESGSS-FSDIDVH---SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREE 344
Query: 330 IETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKG 389
+ +L + +++ T + + EMSY M ET R+ P ++ R + T P + G
Sbjct: 345 VRGILGDGSSI-TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPD-GCTLPAG 402
Query: 390 TLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQ 449
V++ HH+ ++ P+ FDP RFS EN RH A+L F G R CIG A ++
Sbjct: 403 ITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIE 462
Query: 450 YKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
KV + L +RV P + P L+P+ G+Y+ +
Sbjct: 463 LKVTIALILLHFRVTPDPTRPLTF---PNHFILKPKNGMYLHL 502
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 121 bits (292), Expect = 5e-27
Identities = 105/440 (23%), Positives = 192/440 (43%), Gaps = 34/440 (7%)
Query: 74 MFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLT 133
+ R P +I ++ I+ KD ++ F K LGD L + + W R LT
Sbjct: 98 VIRFCHPNIIRSVINASAAIVPKDKVFYS-----FLKPWLGDGLLLSAGEKWSRHRRMLT 152
Query: 134 PMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATI---MACSFSM 190
P F LK +++ +++ + + H ++ + +F ++ T+ C FS
Sbjct: 153 PAFHFNILKPYMKIFNESVN--IMHAKWQLLASKGYARLDMFEHISLMTLDSLQKCVFSF 210
Query: 191 ETDINDMQ---VYEMLNVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEF- 246
++ + + +L ++ ++ + + T G C + +F
Sbjct: 211 DSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPD---GQRFRRACRLVHDFT 267
Query: 247 ---IKNERNGKPANRNDMMDMLLGVNCDK------LKMKNGSEDFVEITEHVMAGQVFVF 297
I+ R P+ D D L K + + + ED ++++ + + F
Sbjct: 268 DAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTF 325
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN-NVLTLEAINEMSYLEMIF 356
G+ L++ LYHLAK QER +E++ +L++ + + + ++ +L M
Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCI 385
Query: 357 LETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPER 416
E+LR+HP + R +D +P + I KG + LI HH+ ++P+PE +DP R
Sbjct: 386 KESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFR 444
Query: 417 FSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKID 476
F +N K R AF+ F GPR CIG A + KV + L ++RV P T+ K +
Sbjct: 445 FDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPD-HTEPRRKPE 503
Query: 477 PLRTALEPEGGVYVDILPRS 496
L EGG+++ + P S
Sbjct: 504 ---LVLRAEGGIWLRVEPLS 520
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 120 bits (290), Expect = 9e-27
Identities = 96/406 (23%), Positives = 178/406 (43%), Gaps = 25/406 (6%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KF + LG L + + W++ R LTP F L++ + ++++ + V + +
Sbjct: 125 KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-- 182
Query: 167 PEQELVSLFLKYNIATI-MACSFSMETDI----ND-----MQVYEMLNVAVFENSYISEL 216
QE + F + + + C +M +I ND VY M + +F + L
Sbjct: 183 --QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM-IFRRIKMPWL 239
Query: 217 --DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDK-- 272
D+ + ++ F ++ NE N R D N +
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 273 --LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREI 330
L + ++ ++ + +V F G+ + +SLY L + +Q+++ E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 331 ETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+ V + T+E + ++ YLE + ETLR+ P+ RS ED + G + KGT
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGT 417
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+I P A H D + +P PE+F PERF EN + RH A++ F GPR CIG + A ++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
K + L + + S + ++ ++ + L P G+++ + R+
Sbjct: 478 KTILSCILRHFWI-ESNQKREELGLEG-QLILRPSNGIWIKLKRRN 521
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 120 bits (290), Expect = 9e-27
Identities = 99/406 (24%), Positives = 179/406 (44%), Gaps = 29/406 (7%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + + W R LTP F LK +++ +++ + + H ++
Sbjct: 127 FLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASE 184
Query: 168 EQELVSLFLKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFP 221
+ +F ++ T+ C FS ++ + + +L ++ ++ +
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK----- 272
+ T G C + +F I+ R P+ D D L K
Sbjct: 245 FLYYLTPD---GQRFRRACRLVHDFTDAVIQERRRTLPSQGVD--DFLQAKAKSKTLDFI 299
Query: 273 -LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
+ + + ED ++++ + + F G+ L++ LYHLAK QER +E++
Sbjct: 300 DVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQ 359
Query: 332 TVLENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+L++ + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGI 418
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+ LI HH+ ++P+PE +DP RF +N K R AF+ F GPR CIG A +
Sbjct: 419 ICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEM 478
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
KV + L ++RV P T+ K + L EGG+++ + P S
Sbjct: 479 KVVLGLTLLRFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 120 bits (290), Expect = 9e-27
Identities = 96/406 (23%), Positives = 178/406 (43%), Gaps = 25/406 (6%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KF + LG L + + W++ R LTP F L++ + ++++ + V + +
Sbjct: 125 KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-- 182
Query: 167 PEQELVSLFLKYNIATI-MACSFSMETDI----ND-----MQVYEMLNVAVFENSYISEL 216
QE + F + + + C +M +I ND VY M + +F + L
Sbjct: 183 --QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM-IFRRIKMPWL 239
Query: 217 --DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDK-- 272
D+ + ++ F ++ NE N R D N +
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 273 --LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREI 330
L + ++ ++ + +V F G+ + +SLY L + +Q+++ E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 331 ETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+ V + T+E + ++ YLE + ETLR+ P+ RS ED + G + KGT
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGT 417
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+I P A H D + +P PE+F PERF EN + RH A++ F GPR CIG + A ++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
K + L + + S + ++ ++ + L P G+++ + R+
Sbjct: 478 KTILSCILRHFWI-ESNQKREELGLEG-QLILRPSNGIWIKLKRRN 521
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 120 bits (290), Expect = 9e-27
Identities = 96/406 (23%), Positives = 178/406 (43%), Gaps = 25/406 (6%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KF + LG L + + W++ R LTP F L++ + ++++ + V + +
Sbjct: 103 KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-- 160
Query: 167 PEQELVSLFLKYNIATI-MACSFSMETDI----ND-----MQVYEMLNVAVFENSYISEL 216
QE + F + + + C +M +I ND VY M + +F + L
Sbjct: 161 --QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM-IFRRIKMPWL 217
Query: 217 --DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDK-- 272
D+ + ++ F ++ NE N R D N +
Sbjct: 218 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 277
Query: 273 --LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREI 330
L + ++ ++ + +V F G+ + +SLY L + +Q+++ E+
Sbjct: 278 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 337
Query: 331 ETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+ V + T+E + ++ YLE + ETLR+ P+ RS ED + G + KGT
Sbjct: 338 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGT 395
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+I P A H D + +P PE+F PERF EN + RH A++ F GPR CIG + A ++
Sbjct: 396 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 455
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
K + L + + S + ++ ++ + L P G+++ + R+
Sbjct: 456 KTILSCILRHFWI-ESNQKREELGLEG-QLILRPSNGIWIKLKRRN 499
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 120 bits (290), Expect = 9e-27
Identities = 96/406 (23%), Positives = 178/406 (43%), Gaps = 25/406 (6%)
Query: 107 KFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLR 166
KF + LG L + + W++ R LTP F L++ + ++++ + V + +
Sbjct: 125 KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-- 182
Query: 167 PEQELVSLFLKYNIATI-MACSFSMETDI----ND-----MQVYEMLNVAVFENSYISEL 216
QE + F + + + C +M +I ND VY M + +F + L
Sbjct: 183 --QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM-IFRRIKMPWL 239
Query: 217 --DMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDK-- 272
D+ + ++ F ++ NE N R D N +
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 273 --LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREI 330
L + ++ ++ + +V F G+ + +SLY L + +Q+++ E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 331 ETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+ V + T+E + ++ YLE + ETLR+ P+ RS ED + G + KGT
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGT 417
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+I P A H D + +P PE+F PERF EN + RH A++ F GPR CIG + A ++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
K + L + + S + ++ ++ + L P G+++ + R+
Sbjct: 478 KTILSCILRHFWI-ESNQKREELGLEG-QLILRPSNGIWIKLKRRN 521
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 120 bits (289), Expect = 1e-26
Identities = 111/459 (24%), Positives = 205/459 (44%), Gaps = 38/459 (8%)
Query: 58 VFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKE---GLG 114
V ++ YP V + +T P + + DIV+ ++ A ++ I F K LG
Sbjct: 76 VLTQLVATYPQGFVRWLGPIT-PIINLCHPDIVRSVINTSDA-ITDKDIVFYKTLKPWLG 133
Query: 115 DNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSL 174
D L + D W+ R LTP F LK +++ S++ + + H + + +
Sbjct: 134 DGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSAN--IMHAKWQRLAMEGSTCLDV 191
Query: 175 FLKYNIATI---MACSFSMETDINDMQ------VYEMLNVAVFENS-YISELDMVFPGIL 224
F ++ T+ C FS +++ + + E+ + V N+ + D ++ L
Sbjct: 192 FEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLY--FL 249
Query: 225 RKTNRSIFGPT--VNNFCYEIVEFIKNERNGKPANRNDMMDMLL-GVNCDKLKMKNGSED 281
R V++F +++ + R +D + D + + SED
Sbjct: 250 TPCGRRFHRACRLVHDFTDAVIQ--ERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSED 307
Query: 282 F--VEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHN- 338
E+++ + + F G+ L++ LY+LA+ QER +E++ +L++
Sbjct: 308 KNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREP 367
Query: 339 NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLA 398
+ + + ++ +L M E+LR+HP T R +D +P + + I KG + I A
Sbjct: 368 KEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRV-IPKGNVCNINIFA 426
Query: 399 FHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFL 458
HH+ ++P+PE +DP RF EN + R AF+ F GPR CIG + A + KV + L
Sbjct: 427 IHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTL 486
Query: 459 TKYRVAPSTRTKDAYKIDPLRT---ALEPEGGVYVDILP 494
++R+ P R +P RT L E G+++ + P
Sbjct: 487 LRFRILPDHR-------EPRRTPEIVLRAEDGLWLRVEP 518
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 119 bits (287), Expect = 2e-26
Identities = 99/406 (24%), Positives = 178/406 (43%), Gaps = 29/406 (7%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + + W R LTP F LK +++ +++ + + H ++
Sbjct: 127 FLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASE 184
Query: 168 EQELVSLFLKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFP 221
+ +F ++ T+ C FS ++ + + +L ++ ++ +
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK----- 272
+ T G C + +F I+ R P+ D D L K
Sbjct: 245 FLYYLTPD---GQRFRRACRLVHDFTDDVIQERRRTLPSQGVD--DFLQAKAKSKTLDFI 299
Query: 273 -LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
+ + + ED ++++ + + F G+ L++ LYHLAK QER +E++
Sbjct: 300 DVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQ 359
Query: 332 TVLENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+L++ + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGI 418
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+ LI HH+ ++P+PE +DP RF +N K R AF+ F GPR CIG A +
Sbjct: 419 ICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEM 478
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
KV + L +RV P T+ K + L EGG+++ + P S
Sbjct: 479 KVVLGLTLLAFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 119 bits (287), Expect = 2e-26
Identities = 99/406 (24%), Positives = 178/406 (43%), Gaps = 29/406 (7%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + + W R LTP F LK +++ +++ + + H ++
Sbjct: 127 FLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASE 184
Query: 168 EQELVSLFLKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFP 221
+ +F ++ T+ C FS ++ + + +L ++ ++ +
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK----- 272
+ T G C + +F I+ R P+ D D L K
Sbjct: 245 FLYYLTPD---GQRFRRACRLVHDFTDDVIQERRRTLPSQGVD--DFLQAKAKSKTLDFI 299
Query: 273 -LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
+ + + ED ++++ + + F G+ L++ LYHLAK QER +E++
Sbjct: 300 DVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQ 359
Query: 332 TVLENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+L++ + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGI 418
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+ LI HH+ ++P+PE +DP RF +N K R AF+ F GPR CIG A +
Sbjct: 419 ICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEM 478
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
KV + L +RV P T+ K + L EGG+++ + P S
Sbjct: 479 KVVLGLTLLAFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 119 bits (287), Expect = 2e-26
Identities = 99/406 (24%), Positives = 178/406 (43%), Gaps = 29/406 (7%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + + W R LTP F LK +++ +++ + + H ++
Sbjct: 127 FLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVN--IMHAKWQLLASE 184
Query: 168 EQELVSLFLKYNIATI---MACSFSMETDINDMQ---VYEMLNVAVFENSYISELDMVFP 221
+ +F ++ T+ C FS ++ + + +L ++ ++ +
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 222 GILRKTNRSIFGPTVNNFCYEIVEF----IKNERNGKPANRNDMMDMLLGVNCDK----- 272
+ T G C + +F I+ R P+ D D L K
Sbjct: 245 FLYYLTPD---GQRFRRACRLVHDFTDDVIQERRRTLPSQGVD--DFLQAKAKSKTLDFI 299
Query: 273 -LKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
+ + + ED ++++ + + F G+ L++ LYHLAK QER +E++
Sbjct: 300 DVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQ 359
Query: 332 TVLENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGT 390
+L++ + + + ++ +L M E+LR+HP + R +D +P + I KG
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGI 418
Query: 391 LVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQY 450
+ LI HH+ ++P+PE +DP RF +N K R AF+ F GPR CIG A +
Sbjct: 419 ICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEM 478
Query: 451 KVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILPRS 496
KV + L +RV P T+ K + L EGG+++ + P S
Sbjct: 479 KVVLGLTLLAFRVLPD-HTEPRRKPE---LVLRAEGGLWLRVEPLS 520
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 114 bits (275), Expect = 6e-25
Identities = 108/425 (25%), Positives = 182/425 (42%), Gaps = 32/425 (7%)
Query: 58 VFKEIYDQYPDEKV--VGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGD 115
V+ ++ ++YP VG F M V D D K I++K + K + +G
Sbjct: 68 VYHKLMEKYPCAVPLWVGPFTMF---FSVHDPDYAK-ILLKRQDPKSAVSHKILESWVGR 123
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L D WK R + P F+ LK + ++S++ ++ + EL
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183
Query: 176 LKYNIATIMACSFSMETDINDMQVYEMLNVAVFE---------NSYISELDMVFPGILRK 226
+ +IM C+FS + I + AVF N+++ D+VF +
Sbjct: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQG 243
Query: 227 TNRSIFGPTVNNFCYEIVEFIKNERNGK------PANRNDMMDMLLGVNCDKLKMKNGSE 280
S F ++ F ++++ K K R D +D+LL + K
Sbjct: 244 QIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTK------ 297
Query: 281 DFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV 340
DF E + +V F AG+ + +++ LY LAK Q+R EI +L + +++
Sbjct: 298 DFSEAD---LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSI 354
Query: 341 LTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFH 400
T E +++M Y M E LR++ + R + T P + G V I A H
Sbjct: 355 -TWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALH 412
Query: 401 HDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTK 460
H+ + +P+ F+P RFS EN + H AF+ F G R CIG A ++ KV + L +
Sbjct: 413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472
Query: 461 YRVAP 465
+++AP
Sbjct: 473 FKLAP 477
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 114 bits (275), Expect = 6e-25
Identities = 108/425 (25%), Positives = 182/425 (42%), Gaps = 32/425 (7%)
Query: 58 VFKEIYDQYPDEKV--VGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGD 115
V+ ++ ++YP VG F M V D D K I++K + K + +G
Sbjct: 68 VYHKLMEKYPCAVPLWVGPFTMF---FSVHDPDYAK-ILLKRQDPKSAVSHKILESWVGR 123
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L D WK R + P F+ LK + ++S++ ++ + EL
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183
Query: 176 LKYNIATIMACSFSMETDINDMQVYEMLNVAVFE---------NSYISELDMVFPGILRK 226
+ +IM C+FS + I + AVF N+++ D+VF +
Sbjct: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQG 243
Query: 227 TNRSIFGPTVNNFCYEIVEFIKNERNGK------PANRNDMMDMLLGVNCDKLKMKNGSE 280
S F ++ F ++++ K K R D +D+LL + K
Sbjct: 244 QIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTK------ 297
Query: 281 DFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV 340
DF E + +V F AG+ + +++ LY LAK Q+R EI +L + +++
Sbjct: 298 DFSEAD---LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSI 354
Query: 341 LTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFH 400
T E +++M Y M E LR++ + R + T P + G V I A H
Sbjct: 355 -TWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALH 412
Query: 401 HDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTK 460
H+ + +P+ F+P RFS EN + H AF+ F G R CIG A ++ KV + L +
Sbjct: 413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472
Query: 461 YRVAP 465
+++AP
Sbjct: 473 FKLAP 477
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 114 bits (275), Expect = 6e-25
Identities = 108/425 (25%), Positives = 182/425 (42%), Gaps = 32/425 (7%)
Query: 58 VFKEIYDQYPDEKV--VGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGD 115
V+ ++ ++YP VG F M V D D K I++K + K + +G
Sbjct: 68 VYHKLMEKYPCAVPLWVGPFTMF---FSVHDPDYAK-ILLKRQDPKSAVSHKILESWVGR 123
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L D WK R + P F+ LK + ++S++ ++ + EL
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183
Query: 176 LKYNIATIMACSFSMETDINDMQVYEMLNVAVFE---------NSYISELDMVFPGILRK 226
+ +IM C+FS + I + AVF N+++ D+VF +
Sbjct: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQG 243
Query: 227 TNRSIFGPTVNNFCYEIVEFIKNERNGK------PANRNDMMDMLLGVNCDKLKMKNGSE 280
S F ++ F ++++ K K R D +D+LL + K
Sbjct: 244 QIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTK------ 297
Query: 281 DFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV 340
DF E + +V F AG+ + +++ LY LAK Q+R EI +L + +++
Sbjct: 298 DFSEAD---LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSI 354
Query: 341 LTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFH 400
T E +++M Y M E LR++ + R + T P + G V I A H
Sbjct: 355 -TWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALH 412
Query: 401 HDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTK 460
H+ + +P+ F+P RFS EN + H AF+ F G R CIG A ++ KV + L +
Sbjct: 413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472
Query: 461 YRVAP 465
+++AP
Sbjct: 473 FKLAP 477
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 114 bits (275), Expect = 6e-25
Identities = 108/425 (25%), Positives = 182/425 (42%), Gaps = 32/425 (7%)
Query: 58 VFKEIYDQYPDEKV--VGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGD 115
V+ ++ ++YP VG F M V D D K I++K + K + +G
Sbjct: 68 VYHKLMEKYPCAVPLWVGPFTMF---FSVHDPDYAK-ILLKRQDPKSAVSHKILESWVGR 123
Query: 116 NLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLF 175
L D WK R + P F+ LK + ++S++ ++ + EL
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183
Query: 176 LKYNIATIMACSFSMETDINDMQVYEMLNVAVFE---------NSYISELDMVFPGILRK 226
+ +IM C+FS + I + AVF N+++ D+VF +
Sbjct: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQG 243
Query: 227 TNRSIFGPTVNNFCYEIVEFIKNERNGK------PANRNDMMDMLLGVNCDKLKMKNGSE 280
S F ++ F ++++ K K R D +D+LL + K
Sbjct: 244 QIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTK------ 297
Query: 281 DFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNV 340
DF E + +V F AG+ + +++ LY LAK Q+R EI +L + +++
Sbjct: 298 DFSEAD---LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSI 354
Query: 341 LTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFH 400
T E +++M Y M E LR++ + R + T P + G V I A H
Sbjct: 355 -TWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALH 412
Query: 401 HDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTK 460
H+ + +P+ F+P RFS EN + H AF+ F G R CIG A ++ KV + L +
Sbjct: 413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472
Query: 461 YRVAP 465
+++AP
Sbjct: 473 FKLAP 477
>DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P450,
family 3, subfamily A, polypeptide 5 protein.
Length = 347
Score = 110 bits (264), Expect = 1e-23
Identities = 86/314 (27%), Positives = 147/314 (46%), Gaps = 20/314 (6%)
Query: 33 IAGPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
I GP P L GN+ R+ + E Y +Y K+ G + P L + D D+++
Sbjct: 38 IPGPTPLPLLGNV---LSYRQGLWKFDTECYKKYG--KMWGTYEGQLPVLAITDPDVIRT 92
Query: 93 IMIKD-YAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQT 151
+++K+ Y+ F R + + A+ + WK +RS L+P F+SGKLK M +++Q
Sbjct: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD-INDMQ------VYEMLN 204
GD V ++ E L +F Y++ I SF + D +N+ Q + L
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212
Query: 205 VAVFENSYISELDMVF-PGILRKTNRSIFGPTVNNFCYEIVEFIKNER-NGKPANRNDMM 262
+ ++S + F + N S+F NF + V +K R N K +R D +
Sbjct: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272
Query: 263 DMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
+++ D K +E +++ +A Q +F AGY + L+F+LY LA +
Sbjct: 273 QLMI----DSQNSKE-TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327
Query: 323 QERLMREIETVLEN 336
Q++L +EI+ VL N
Sbjct: 328 QQKLQKEIDAVLPN 341
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 107 bits (258), Expect = 7e-23
Identities = 56/151 (37%), Positives = 87/151 (57%), Gaps = 4/151 (2%)
Query: 342 TLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHH 401
T +A+ +M YL+M+ ETLR+ P L+R+ +D I G + I KG++V+IP A HH
Sbjct: 17 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING--VFIPKGSMVVIPTYALHH 74
Query: 402 DEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
D K + EPE+F PERFS + S + FG GPR CIG+R A + K+ +++ L +
Sbjct: 75 DPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 133
Query: 462 RVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
P T+ K+D + L+PE + + +
Sbjct: 134 SFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 163
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 107 bits (258), Expect = 7e-23
Identities = 56/151 (37%), Positives = 87/151 (57%), Gaps = 4/151 (2%)
Query: 342 TLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHH 401
T +A+ +M YL+M+ ETLR+ P L+R+ +D I G + I KG++V+IP A HH
Sbjct: 4 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING--VFIPKGSMVVIPTYALHH 61
Query: 402 DEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
D K + EPE+F PERFS + S + FG GPR CIG+R A + K+ +++ L +
Sbjct: 62 DPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 120
Query: 462 RVAPSTRTKDAYKIDPLRTALEPEGGVYVDI 492
P T+ K+D + L+PE + + +
Sbjct: 121 SFKPCKETQIPLKLD-TQGLLQPEKPIVLKV 150
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 106 bits (255), Expect = 2e-22
Identities = 96/402 (23%), Positives = 177/402 (44%), Gaps = 25/402 (6%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + D W R LTP F LK +++ +Q+ D + H + R
Sbjct: 135 FLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHA--KWRHLA 190
Query: 168 EQELVSLFLKYNIA-----TIMACSFSMETDINDMQ------VYEMLNVAVFENSYISE- 215
E VSL + +I+ ++ C FS ++ + + E+ ++V +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 216 LDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKN--ERNGKPANRNDMMDMLLGVNCDKL 273
LD ++ V++F E+++ + R G A L D L
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRRQGAEAWLKAKQGKTLDF-IDVL 309
Query: 274 KMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ ED E+++ + + F G+ + +++ L++LAK QE+ EI+ V
Sbjct: 310 LLAR-DEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEV 368
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
++ L + + ++ + M E+LR +P + R ED +P I I KG +
Sbjct: 369 MKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI-IPKGIIC 427
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
L+ HH+ ++P+ + ++P RF +N + R A++ F GPR CIG A + +V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L ++R++ RT+ + L L E G+++ + P
Sbjct: 488 VVALTLLRFRLSVD-RTRKVRRKPEL--ILRTENGLWLKVEP 526
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 106 bits (254), Expect = 2e-22
Identities = 93/402 (23%), Positives = 177/402 (44%), Gaps = 25/402 (6%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + D W R LTP F LK +++ +Q+ D + H + R
Sbjct: 135 FLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHA--KWRHLA 190
Query: 168 EQELVSLFLKYNIA-----TIMACSFSMETDINDMQ------VYEMLNVAVFENSYISE- 215
E VSL + +I+ ++ C FS ++ + + E+ ++V +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 216 LDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDKLK- 274
LD ++ V++F E+++ + R + + G D +
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQ--ERRRALRQQGAEAWLKAKQGKTLDFIDV 308
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ ED E+++ + + F G+ + +++ L++LAK QE+ EI+ V
Sbjct: 309 LLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEV 368
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
++ L + + ++ + M E+LR +P + R ED +P I I KG +
Sbjct: 369 MKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI-IPKGIIC 427
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
L+ HH+ ++P+ + ++P RF +N + R A++ F GPR CIG A + +V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L ++R++ RT+ + L L E G+++ + P
Sbjct: 488 VVALTLLRFRLSVD-RTRKVRRKPEL--ILRTENGLWLKVEP 526
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 106 bits (254), Expect = 2e-22
Identities = 93/402 (23%), Positives = 177/402 (44%), Gaps = 25/402 (6%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + D W R LTP F LK +++ +Q+ D + H + R
Sbjct: 135 FLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHA--KWRHLA 190
Query: 168 EQELVSLFLKYNIA-----TIMACSFSMETDINDMQ------VYEMLNVAVFENSYISE- 215
E VSL + +I+ ++ C FS ++ + + E+ ++V +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 216 LDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDKLK- 274
LD ++ V++F E+++ + R + + G D +
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQ--ERRRALRQQGAEAWLKAKQGKTLDFIDV 308
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ ED E+++ + + F G+ + +++ L++LAK QE+ EI+ V
Sbjct: 309 LLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEV 368
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
++ L + + ++ + M E+LR +P + R ED +P I I KG +
Sbjct: 369 MKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI-IPKGIIC 427
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
L+ HH+ ++P+ + ++P RF +N + R A++ F GPR CIG A + +V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L ++R++ RT+ + L L E G+++ + P
Sbjct: 488 VVALTLLRFRLSVD-RTRKVRRKPEL--ILRTENGLWLKVEP 526
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 106 bits (254), Expect = 2e-22
Identities = 93/402 (23%), Positives = 177/402 (44%), Gaps = 25/402 (6%)
Query: 108 FSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRP 167
F K LGD L + D W R LTP F LK +++ +Q+ D + H + R
Sbjct: 135 FLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHA--KWRHLA 190
Query: 168 EQELVSLFLKYNIA-----TIMACSFSMETDINDMQ------VYEMLNVAVFENSYISE- 215
E VSL + +I+ ++ C FS ++ + + E+ ++V +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 216 LDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMDMLLGVNCDKLK- 274
LD ++ V++F E+++ + R + + G D +
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQ--ERRRALRQQGAEAWLKAKQGKTLDFIDV 308
Query: 275 -MKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETV 333
+ ED E+++ + + F G+ + +++ L++LAK QE+ EI+ V
Sbjct: 309 LLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEV 368
Query: 334 LENHN-NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLV 392
++ L + + ++ + M E+LR +P + R ED +P I I KG +
Sbjct: 369 MKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI-IPKGIIC 427
Query: 393 LIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKV 452
L+ HH+ ++P+ + ++P RF +N + R A++ F GPR CIG A + +V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
Query: 453 CMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYVDILP 494
+ L ++R++ RT+ + L L E G+++ + P
Sbjct: 488 VVALTLLRFRLSVD-RTRKVRRKPEL--ILRTENGLWLKVEP 526
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 98.7 bits (235), Expect = 4e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 98.7 bits (235), Expect = 4e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 98.7 bits (235), Expect = 4e-20
Identities = 110/424 (25%), Positives = 184/424 (43%), Gaps = 39/424 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + KF +G +L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E + TIM +FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS-TRTKDAYKIDPLRTALEPEG 486
AFL F G R CIG + A Q KV L ++ + P TRT I R L+ +
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRT----PIPMARLVLKSKN 500
Query: 487 GVYV 490
G+++
Sbjct: 501 GIHL 504
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 97.5 bits (232), Expect = 9e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 97.5 bits (232), Expect = 9e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 97.5 bits (232), Expect = 9e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 97.5 bits (232), Expect = 9e-20
Identities = 102/398 (25%), Positives = 173/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 96.3 bits (229), Expect = 2e-19
Identities = 102/398 (25%), Positives = 172/398 (43%), Gaps = 34/398 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR+ P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLFPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
AFL F G R CIG + A + KV L ++ + P
Sbjct: 445 HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
>BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein.
Length = 280
Score = 95.9 bits (228), Expect = 3e-19
Identities = 52/128 (40%), Positives = 75/128 (58%), Gaps = 4/128 (3%)
Query: 289 VMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINE 348
++A + + FAA Y + TL F +Y LA +Q++L EI+ VL N V T +A+ +
Sbjct: 155 LVAQSIIIIFAA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPV-TYDALVQ 212
Query: 349 MSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPE 408
M YL+M+ ETLR+ P + + R +D I G + I KG V++P A HHD K + E
Sbjct: 213 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTE 270
Query: 409 PEKFDPER 416
PEKF PER
Sbjct: 271 PEKFCPER 278
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 94.7 bits (225), Expect = 7e-19
Identities = 68/231 (29%), Positives = 110/231 (47%), Gaps = 16/231 (6%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LL KM+NGS +++ + +V F G+ +++ LY LA
Sbjct: 290 DFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTASGISWILYALATH 340
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
QER EI +L + ++ T +++M Y M E LR++P + R T
Sbjct: 341 PKHQERCREEIHGLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTF 399
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+ AFL F G R
Sbjct: 400 PDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGS--AQHSHAFLPFSGGSRN 456
Query: 440 CIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYV 490
CIG + A Q KV L ++ + P I R L+ + G+++
Sbjct: 457 CIGKQFAMNQLKVARALTLLRFELLPD---PTRIPIPMARLVLKSKNGIHL 504
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 94.3 bits (224), Expect = 9e-19
Identities = 108/424 (25%), Positives = 182/424 (42%), Gaps = 39/424 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + KF +G L + W R LTP F + LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM +FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVF---ENSYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--R 251
LN VF N++ E D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNSLVFCCMRNAF-HENDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQK 276
Query: 252 NG-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNT 306
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 277 EGELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTA 327
Query: 307 ITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTT 366
+++ LY LA QER EI +L + ++ T +++M Y M E LR++P
Sbjct: 328 SGISWILYALATHPKHQERCREEIHGLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPV 386
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R T P + KG +VL+ HH+ K++P E FDP RF+ + ++H
Sbjct: 387 PGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGS--AQH 443
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEG 486
+ AFL F G R CIG + A Q KV L ++ + P I R L+ +
Sbjct: 444 SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPD---PTRIPIPMARLVLKSKN 500
Query: 487 GVYV 490
G+++
Sbjct: 501 GIHL 504
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 92.7 bits (220), Expect = 3e-18
Identities = 103/399 (25%), Positives = 173/399 (43%), Gaps = 36/399 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F + LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM +FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVF---ENSYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--R 251
LN VF N++ E D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNSLVFCCMRNAF-HENDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQK 276
Query: 252 NG-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNT 306
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 277 EGELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTA 327
Query: 307 ITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTT 366
+++ LY LA QER EI +L + ++ T +++M Y M E LR++P
Sbjct: 328 SGISWILYALATHPKHQERCREEIHGLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPV 386
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R T P + KG +VL+ HH+ K++P E FDP RF+ + ++H
Sbjct: 387 PGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGS--AQH 443
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
+ AFL F G R CIG + A Q KV L ++ + P
Sbjct: 444 SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 482
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 92.3 bits (219), Expect = 4e-18
Identities = 97/408 (23%), Positives = 178/408 (43%), Gaps = 29/408 (7%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSS 138
+++ L ++K+ +I F R + +E + + L + AWK R LT + +
Sbjct: 89 VLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNF 148
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDIND 196
G K + L + H+T ++ Q F N + + CS F + D
Sbjct: 149 GLGK---KSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 197 ---MQVYEMLN-VAVFENSYISELDMVFPGILR---KTNRSIFG--PTVNNFCYEIVEFI 247
Q+ ++L+ V E S +L VFP I++ ++++F + F +++
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMID-- 263
Query: 248 KNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K+ ++ PA D +D L ++ G+ E+++ + +FFA +T
Sbjct: 264 KHRKDWNPAETRDFIDAYL----KEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTST- 318
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRM-HPTT 366
TL ++L ++A IQE++ EI+ V+ T A M Y + E RM +
Sbjct: 319 TLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNAVIHEVQRMGNIIP 377
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R D T+ G + KGT++L A H D + P+ F+P+ F +EN + +
Sbjct: 378 LNVPREVTVDTTLAG--YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKK 434
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYK 474
AF+ F IG R C+G +LA+ + + + K+ P K + K
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 92.3 bits (219), Expect = 4e-18
Identities = 97/408 (23%), Positives = 178/408 (43%), Gaps = 29/408 (7%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSS 138
+++ L ++K+ +I F R + +E + + L + AWK R LT + +
Sbjct: 89 VLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNF 148
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDIND 196
G K + L + H+T ++ Q F N + + CS F + D
Sbjct: 149 GLGK---KSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 197 ---MQVYEMLN-VAVFENSYISELDMVFPGILR---KTNRSIFG--PTVNNFCYEIVEFI 247
Q+ ++L+ V E S +L VFP I++ ++++F + F +++
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMID-- 263
Query: 248 KNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K+ ++ PA D +D L ++ G+ E+++ + +FFA +T
Sbjct: 264 KHRKDWNPAETRDFIDAYL----KEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTST- 318
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRM-HPTT 366
TL ++L ++A IQE++ EI+ V+ T A M Y + E RM +
Sbjct: 319 TLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNAVIHEVQRMGNIIP 377
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R D T+ G + KGT++L A H D + P+ F+P+ F +EN + +
Sbjct: 378 LNVPREVTVDTTLAG--YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKK 434
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYK 474
AF+ F IG R C+G +LA+ + + + K+ P K + K
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 285 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 335
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 336 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 395 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 452
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 453 NCIGQQFAMSEMKVVTAMCLLRF 475
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 92.3 bits (219), Expect = 4e-18
Identities = 97/408 (23%), Positives = 178/408 (43%), Gaps = 29/408 (7%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSS 138
+++ L ++K+ +I F R + +E + + L + AWK R LT + +
Sbjct: 89 VLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNF 148
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDIND 196
G K + L + H+T ++ Q F N + + CS F + D
Sbjct: 149 GLGK---KSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 197 ---MQVYEMLN-VAVFENSYISELDMVFPGILR---KTNRSIFG--PTVNNFCYEIVEFI 247
Q+ ++L+ V E S +L VFP I++ ++++F + F +++
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMID-- 263
Query: 248 KNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K+ ++ PA D +D L ++ G+ E+++ + +FFA +T
Sbjct: 264 KHRKDWNPAETRDFIDAYL----KEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTST- 318
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRM-HPTT 366
TL ++L ++A IQE++ EI+ V+ T A M Y + E RM +
Sbjct: 319 TLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNAVIHEVQRMGNIIP 377
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R D T+ G + KGT++L A H D + P+ F+P+ F +EN + +
Sbjct: 378 LNVPREVTVDTTLAG--YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKK 434
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYK 474
AF+ F IG R C+G +LA+ + + + K+ P K + K
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 270 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 320
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 321 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 379
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 380 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 437
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 438 NCIGQQFAMSEMKVVTAMCLLRF 460
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 285 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 335
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 336 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 395 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 452
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 453 NCIGQQFAMSEMKVVTAMCLLRF 475
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 270 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 320
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 321 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 379
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 380 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 437
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 438 NCIGQQFAMSEMKVVTAMCLLRF 460
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 285 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 335
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 336 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 395 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 452
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 453 NCIGQQFAMSEMKVVTAMCLLRF 475
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 285 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 335
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 336 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 395 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 452
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 453 NCIGQQFAMSEMKVVTAMCLLRF 475
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 270 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY 320
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 321 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 379
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 380 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 437
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 438 NCIGQQFAMSEMKVVTAMCLLRF 460
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 92.3 bits (219), Expect = 4e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 92.3 bits (219), Expect = 4e-18
Identities = 97/408 (23%), Positives = 178/408 (43%), Gaps = 29/408 (7%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSS 138
+++ L ++K+ +I F R + +E + + L + AWK R LT + +
Sbjct: 89 VLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNF 148
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDIND 196
G K + L + H+T ++ Q F N + + CS F + D
Sbjct: 149 GLGK---KSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 197 ---MQVYEMLN-VAVFENSYISELDMVFPGILR---KTNRSIFG--PTVNNFCYEIVEFI 247
Q+ ++L+ V E S +L VFP I++ ++++F + F +++
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMID-- 263
Query: 248 KNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K+ ++ PA D +D L ++ G+ E+++ + +FFA +T
Sbjct: 264 KHRKDWNPAETRDFIDAYL----KEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTST- 318
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRM-HPTT 366
TL ++L ++A IQE++ EI+ V+ T A M Y + E RM +
Sbjct: 319 TLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNAVIHEVQRMGNIIP 377
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R D T+ G + KGT++L A H D + P+ F+P+ F +EN + +
Sbjct: 378 LNVPREVTVDTTLAG--YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKK 434
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYK 474
AF+ F IG R C+G +LA+ + + + K+ P K + K
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 91.5 bits (217), Expect = 6e-18
Identities = 58/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D +D+LLG ED +++++ + +V F G+ T +++ LY +A
Sbjct: 284 DFLDILLGAR---------DEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALY 334
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT- 378
Q R E+ +L + + + + +M+YL M E+ R++P + R + T
Sbjct: 335 PEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 393
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
+ G + G+L+ + A H + ++P+PE FD RFS EN RH AF+ F GPR
Sbjct: 394 VDGRSLPA--GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPR 451
Query: 439 TCIGIRLAKLQYKV----CMVKF 457
CIG + A + KV C+++F
Sbjct: 452 NCIGQQFAMSEMKVVTAMCLLRF 474
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 91.5 bits (217), Expect = 6e-18
Identities = 97/408 (23%), Positives = 178/408 (43%), Gaps = 29/408 (7%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSS 138
+++ L ++K+ +I F R + +E + + L + AWK R LT + +
Sbjct: 89 VLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNF 148
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDIND 196
G K + L + H+T ++ Q F N + + CS F + D
Sbjct: 149 GLGK---KSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 197 ---MQVYEMLN-VAVFENSYISELDMVFPGILR---KTNRSIFG--PTVNNFCYEIVEFI 247
Q+ ++L+ V E S +L VFP I++ ++++F + F +++
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMID-- 263
Query: 248 KNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K+ ++ PA D +D L ++ G+ E+++ + +FFA +T
Sbjct: 264 KHRKDWNPAETRDFIDAYL----KEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTST- 318
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRM-HPTT 366
TL ++L ++A IQE++ EI+ V+ T A M Y + E RM +
Sbjct: 319 TLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTA-ARESMPYTNAVIHEVQRMGNIIP 377
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R D T+ G + KGT++L A H D + P+ F+P+ F +EN + +
Sbjct: 378 LNVPREVTVDTTLAG--YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKK 434
Query: 427 ACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYK 474
AF+ F IG R C+G +LA+ + + + K+ P K + K
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 90.6 bits (215), Expect = 1e-17
Identities = 100/385 (25%), Positives = 169/385 (43%), Gaps = 33/385 (8%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC-QLSHQHTRPKVIQLRKAQLQKE 278
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 279 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 329
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 330 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 388
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 389 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 445
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKV 452
AFL F G R CIG + A + KV
Sbjct: 446 HAFLPFSGGSRNCIGKQFAMNELKV 470
>M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase
protein.
Length = 460
Score = 90.2 bits (214), Expect = 1e-17
Identities = 48/133 (36%), Positives = 71/133 (53%), Gaps = 2/133 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T + GQ F+F AGY T TL+F+ Y LA + QE+L+RE++ E H
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 386
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ YL+M+ ETLRM+P R A +D + G I G ++ + A HHD +
Sbjct: 387 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVLEMAVGALHHDPE 444
Query: 405 IYPEPEKFDPERF 417
+P PE F+PER+
Sbjct: 445 HWPSPETFNPERY 457
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 82 LIVRDLDIVKQIMIKDYAKFNER---GIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSS 138
+++ + D++KQ+++++++ F R G++F + + D++ W+ VR L FS
Sbjct: 89 IVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVRGALMSAFSP 146
Query: 139 GKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFSMETD 193
KL MV ++SQ D + H+ ++ + Y + + F D
Sbjct: 147 EKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVD 201
>AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family
27, subfamily B, polypeptide 1 protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin D-1
alpha hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 88.2 bits (209), Expect = 6e-17
Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 8/214 (3%)
Query: 284 EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVL-T 342
E+ + G V AG + TL+++LY L++ +Q L EI L ++ +
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
Query: 343 LEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHD 402
++++ L+ + E LR++P S + D I D I K TLV + A D
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPG--NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRD 418
Query: 403 EKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYR 462
+PEP F P R+ E + H A L FG G R+C+G RLA+L+ ++ + + LT +
Sbjct: 419 PAQFPEPNSFRPARWLGEG-PTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477
Query: 463 VAPSTRTKDAYKIDP-LRTALEPEGGVYVDILPR 495
V P A + P RT L PE + + L R
Sbjct: 478 VQPE---PGAAPVRPKTRTVLVPERSINLQFLDR 508
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 85.0 bits (201), Expect = 5e-16
Identities = 109/475 (22%), Positives = 197/475 (41%), Gaps = 45/475 (9%)
Query: 36 PEPEFLFGNL----KESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVK 91
P P FL G+L K+ + + VF + +Y V +F TS +IV + VK
Sbjct: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTS--VIVTSPESVK 94
Query: 92 QIMI-----KDYAKFNERGIKFSKEGLGDNLF-HADADAWKAVRSHLTPMFSSGKLKNMV 145
+ ++ KD + F + G L + + W R + FS L +++
Sbjct: 95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLM 154
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMA-CSFSMETDINDMQVYEMLN 204
++ ++ V+ + + + + + L Y I+A +F MET + + + L+
Sbjct: 155 ETFNEKAEQLVEILEAKADGQTPVSMQDM-LTYTAMDILAKAAFGMETSML-LGAQKPLS 212
Query: 205 VAV---FENSYISE--LDMVFPGILRKTNRSIFGPTVNNFCYEIV-EFIKNERNGKPANR 258
AV E S L PG RK R + F ++ ++++ R
Sbjct: 213 QAVKLMLEGITASRNTLAKFLPG-KRKQLREVRESI--RFLRQVGRDWVQRRREALKRGE 269
Query: 259 NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
D+L + LK + G++D + ++ + FF AG+ + L F++ L++
Sbjct: 270 EVPADILTQI----LKAEEGAQDDEGLLDNFVT-----FFIAGHETSANHLAFTVMELSR 320
Query: 319 DQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT 378
I RL E++ V+ L E + + YL + E+LR++P R E+
Sbjct: 321 QPEIVARLQAEVDEVI-GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETL 379
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
I G + + T +L + + +P F+P+RF K R + F +G R
Sbjct: 380 IDG--VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF--TYFPFSLGHR 435
Query: 439 TCIGIRLAKLQYKVCMVKFLTK--YRVAPSTR-----TKDAYKIDPLRTALEPEG 486
+CIG + A+++ KV M K L + +R+ P R +DP+ L P G
Sbjct: 436 SCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 85.0 bits (201), Expect = 5e-16
Identities = 109/475 (22%), Positives = 197/475 (41%), Gaps = 45/475 (9%)
Query: 36 PEPEFLFGNL----KESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVK 91
P P FL G+L K+ + + VF + +Y V +F TS +IV + VK
Sbjct: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTS--VIVTSPESVK 94
Query: 92 QIMI-----KDYAKFNERGIKFSKEGLGDNLF-HADADAWKAVRSHLTPMFSSGKLKNMV 145
+ ++ KD + F + G L + + W R + FS L +++
Sbjct: 95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLM 154
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMA-CSFSMETDINDMQVYEMLN 204
++ ++ V+ + + + + + L Y I+A +F MET + + + L+
Sbjct: 155 ETFNEKAEQLVEILEAKADGQTPVSMQDM-LTYTAMDILAKAAFGMETSML-LGAQKPLS 212
Query: 205 VAV---FENSYISE--LDMVFPGILRKTNRSIFGPTVNNFCYEIV-EFIKNERNGKPANR 258
AV E S L PG RK R + F ++ ++++ R
Sbjct: 213 QAVKLMLEGITASRNTLAKFLPG-KRKQLREVRESI--RFLRQVGRDWVQRRREALKRGE 269
Query: 259 NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
D+L + LK + G++D + ++ + FF AG+ + L F++ L++
Sbjct: 270 EVPADILTQI----LKAEEGAQDDEGLLDNFVT-----FFIAGHETSANHLAFTVMELSR 320
Query: 319 DQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYT 378
I RL E++ V+ L E + + YL + E+LR++P R E+
Sbjct: 321 QPEIVARLQAEVDEVI-GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETL 379
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPR 438
I G + + T +L + + +P F+P+RF K R + F +G R
Sbjct: 380 IDG--VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF--TYFPFSLGHR 435
Query: 439 TCIGIRLAKLQYKVCMVKFLTK--YRVAPSTR-----TKDAYKIDPLRTALEPEG 486
+CIG + A+++ KV M K L + +R+ P R +DP+ L P G
Sbjct: 436 SCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 83.4 bits (197), Expect = 2e-15
Identities = 49/156 (31%), Positives = 88/156 (56%), Gaps = 4/156 (2%)
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+L + LY+L+++ +Q++L++EI++VL N V E + M YL+ E++R+ P+
Sbjct: 77 SLMWILYNLSRNPQVQQKLLKEIQSVLPE-NQVPRAEDLRNMPYLKACLKESMRLTPSVP 135
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
R+ L+ T+ G + + KGT++++ E + + +F PER+ E K +
Sbjct: 136 FTTRT-LDKATVLG-EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-NP 192
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
A L FG+G R CIG RLA+LQ + + + KY +
Sbjct: 193 FAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 228
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 83.4 bits (197), Expect = 2e-15
Identities = 49/156 (31%), Positives = 88/156 (56%), Gaps = 4/156 (2%)
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+L + LY+L+++ +Q++L++EI++VL N V E + M YL+ E++R+ P+
Sbjct: 192 SLMWILYNLSRNPQVQQKLLKEIQSVLPE-NQVPRAEDLRNMPYLKACLKESMRLTPSVP 250
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
R+ L+ T+ G + + KGT++++ E + + +F PER+ E K +
Sbjct: 251 FTTRT-LDKATVLG-EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-NP 307
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
A L FG+G R CIG RLA+LQ + + + KY +
Sbjct: 308 FAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 343
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 83.4 bits (197), Expect = 2e-15
Identities = 49/156 (31%), Positives = 88/156 (56%), Gaps = 4/156 (2%)
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+L + LY+L+++ +Q++L++EI++VL N V E + M YL+ E++R+ P+
Sbjct: 334 SLMWILYNLSRNPQVQQKLLKEIQSVLPE-NQVPRAEDLRNMPYLKACLKESMRLTPSVP 392
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
R+ L+ T+ G + + KGT++++ E + + +F PER+ E K +
Sbjct: 393 FTTRT-LDKATVLG-EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-NP 449
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
A L FG+G R CIG RLA+LQ + + + KY +
Sbjct: 450 FAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 485
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 83.4 bits (197), Expect = 2e-15
Identities = 49/156 (31%), Positives = 88/156 (56%), Gaps = 4/156 (2%)
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+L + LY+L+++ +Q++L++EI++VL N V E + M YL+ E++R+ P+
Sbjct: 192 SLMWILYNLSRNPQVQQKLLKEIQSVLPE-NQVPRAEDLRNMPYLKACLKESMRLTPSVP 250
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
R+ L+ T+ G + + KGT++++ E + + +F PER+ E K +
Sbjct: 251 FTTRT-LDKATVLG-EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-NP 307
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
A L FG+G R CIG RLA+LQ + + + KY +
Sbjct: 308 FAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 343
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 82.6 bits (195), Expect = 3e-15
Identities = 94/371 (25%), Positives = 160/371 (43%), Gaps = 34/371 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPR 438
AFL F G R
Sbjct: 445 HAFLPFSGGSR 455
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 82.6 bits (195), Expect = 3e-15
Identities = 94/371 (25%), Positives = 160/371 (43%), Gaps = 34/371 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + +F +G L + W R LTP F LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM C+FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVFEN--SYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--RN 252
LN VF + + D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQKE 277
Query: 253 G-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 278 GELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTAS 328
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+++ LY LA QER EI ++L + ++ T +++M Y M E LR++P
Sbjct: 329 GISWILYALATHPKHQERCREEIHSLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPVP 387
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
+ R T P + KG +VL+ HH+ K++P PE FDP RF+ + ++H+
Sbjct: 388 GIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS--AQHS 444
Query: 428 CAFLSFGIGPR 438
AFL F G R
Sbjct: 445 HAFLPFSGGSR 455
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 81.8 bits (193), Expect = 5e-15
Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 9/200 (4%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TLT++LYHL+KD IQE L E+ V+ V + M L+ + ET
Sbjct: 334 AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKET 392
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR++P T R ++ + G K T + D + EPE F P R+
Sbjct: 393 LRLYPVVPTNSRIIEKEIEVDG--FLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 450
Query: 420 ENHKS----RHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
+ + +H + FG G R C+G R+A+L+ ++ + + + KY+V + T + +
Sbjct: 451 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 510
Query: 476 DPLRTALEPEGGVYVDILPR 495
R L P V + L R
Sbjct: 511 --ARIVLVPNKKVGLQFLQR 528
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 81.8 bits (193), Expect = 5e-15
Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 9/200 (4%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TLT++LYHL+KD IQE L E+ V+ V + M L+ + ET
Sbjct: 335 AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKET 393
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR++P T R ++ + G K T + D + EPE F P R+
Sbjct: 394 LRLYPVVPTNSRIIEKEIEVDG--FLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 451
Query: 420 ENHKS----RHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
+ + +H + FG G R C+G R+A+L+ ++ + + + KY+V + T + +
Sbjct: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
Query: 476 DPLRTALEPEGGVYVDILPR 495
R L P V + L R
Sbjct: 512 --ARIVLVPNKKVGLQFLQR 529
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 81.8 bits (193), Expect = 5e-15
Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 9/200 (4%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TLT++LYHL+KD IQE L E+ V+ V + M L+ + ET
Sbjct: 335 AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKET 393
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR++P T R ++ + G K T + D + EPE F P R+
Sbjct: 394 LRLYPVVPTNSRIIEKEIEVDG--FLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 451
Query: 420 ENHKS----RHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
+ + +H + FG G R C+G R+A+L+ ++ + + + KY+V + T + +
Sbjct: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
Query: 476 DPLRTALEPEGGVYVDILPR 495
R L P V + L R
Sbjct: 512 --ARIVLVPNKKVGLQFLQR 529
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 81.8 bits (193), Expect = 5e-15
Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 9/200 (4%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TLT++LYHL+KD IQE L E+ V+ V + M L+ + ET
Sbjct: 335 AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKET 393
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR++P T R ++ + G K T + D + EPE F P R+
Sbjct: 394 LRLYPVVPTNSRIIEKEIEVDG--FLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 451
Query: 420 ENHKS----RHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
+ + +H + FG G R C+G R+A+L+ ++ + + + KY+V + T + +
Sbjct: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
Query: 476 DPLRTALEPEGGVYVDILPR 495
R L P V + L R
Sbjct: 512 --ARIVLVPNKKVGLQFLQR 529
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 81.4 bits (192), Expect = 7e-15
Identities = 61/214 (28%), Positives = 102/214 (47%), Gaps = 18/214 (8%)
Query: 257 NRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHL 316
N D +DM L ++ ++ + N + F E + G +F+ AG T +L + L ++
Sbjct: 313 NPQDFIDMYL-LHMEEERKNNSNSSFDEEYLFYIIGDLFI---AGTDTTTNSLLWCLLYM 368
Query: 317 AKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN------TLQ 370
+ + +QE++ EIE V+ N +L +M Y E +E R+ T +
Sbjct: 369 SLNPDVQEKVHEEIERVI-GANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSE 427
Query: 371 RSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAF 430
+ L+ YTIP KGTL+L + H D I+ +PE F P RF + + F
Sbjct: 428 NTVLQGYTIP-------KGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480
Query: 431 LSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+ FGIG R C+G +LAK++ + V + + A
Sbjct: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 81.4 bits (192), Expect = 7e-15
Identities = 61/214 (28%), Positives = 102/214 (47%), Gaps = 18/214 (8%)
Query: 257 NRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHL 316
N D +DM L ++ ++ + N + F E + G +F+ AG T +L + L ++
Sbjct: 313 NPQDFIDMYL-LHMEEERKNNSNSSFDEEYLFYIIGDLFI---AGTDTTTNSLLWCLLYM 368
Query: 317 AKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN------TLQ 370
+ + +QE++ EIE V+ N +L +M Y E +E R+ T +
Sbjct: 369 SLNPDVQEKVHEEIERVI-GANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSE 427
Query: 371 RSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAF 430
+ L+ YTIP KGTL+L + H D I+ +PE F P RF + + F
Sbjct: 428 NTVLQGYTIP-------KGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480
Query: 431 LSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVA 464
+ FGIG R C+G +LAK++ + V + + A
Sbjct: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 80.6 bits (190), Expect = 1e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 68 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 122
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 123 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 182
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 183 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 239
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 240 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 299
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 300 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLP 358
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 359 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGDNFKKS 417
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 418 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 80.6 bits (190), Expect = 1e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 68 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 122
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 123 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 182
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 183 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 239
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 240 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 299
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 300 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLP 358
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 359 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGDNFKKS 417
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 418 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 60 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 114
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 115 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 174
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 175 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 231
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 232 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 291
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 292 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 350
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 351 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 409
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 410 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 445
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 228 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 285
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 286 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 341
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 342 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 228 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 285
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 286 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 341
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 342 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 70 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 124
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 125 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 184
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 185 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 241
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 242 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 301
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 302 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 360
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 361 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 419
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 420 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 455
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 73 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 127
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 187
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 188 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 364 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 306 TITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPT 365
+++L F L+ +AK +++E +++EI+TV+ + + ++ I ++ +E E++R P
Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMRYQPV 369
Query: 366 TNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSR 425
+ + R ALED I G ++KGT +++ H E +P+P +F E F+ +N R
Sbjct: 370 VDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA-KNVPYR 425
Query: 426 HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ F FG GPR C G +A + K +V L ++ V
Sbjct: 426 Y---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 73 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 127
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 187
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 188 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 364 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 73 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 127
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 187
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 188 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 364 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 80.2 bits (189), Expect = 2e-14
Identities = 95/396 (23%), Positives = 154/396 (38%), Gaps = 22/396 (5%)
Query: 80 PTLIVRDLDIVKQIMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSHLTPMFS 137
P +++ + VK+ +I +F+ RGI + G + ++ WK +R FS
Sbjct: 73 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRR-----FS 127
Query: 138 SGKLKNMVRVLSQTGDRFVDH---VTNEVRLRPEQELVSLFLKYNIATIMACS--FSMET 192
L+N DR + + E+R F+ + CS F
Sbjct: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 187
Query: 193 DINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSI-FGPTVNNFCYEIVEFIKNER 251
D D Q LN+ N I L + I + I + P +N + V F+K+
Sbjct: 188 DYKDQQ---FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
Query: 252 NGKPANRNDMMDMLLG---VNCDKLKM-KNGSEDFVEITEHVMAGQVFVFFAAGYVNNTI 307
K + MDM ++C +KM K E T + F AG +
Sbjct: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
T A+ I + I KGT +LI + HD K +P PE FDP F E + +
Sbjct: 364 TSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
F+ F G R C+G LA ++ + + L + +
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 79.8 bits (188), Expect = 2e-14
Identities = 56/200 (28%), Positives = 92/200 (46%), Gaps = 9/200 (4%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TLT++LYHL+KD IQ+ L E+ V+ V + M L+ + ET
Sbjct: 335 AGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPA-GQVPQHKDFAHMPLLKAVLKET 393
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR++P T R ++ + G K T + D + EPE F P R+
Sbjct: 394 LRLYPVVPTNSRIIEKEIEVDG--FLFPKNTQFVFCHYEVSRDPTAFSEPESFQPHRWLR 451
Query: 420 ENHKS----RHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKI 475
+ + +H + FG G R C+G R+A+L+ ++ + + + KY+V + T + +
Sbjct: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
Query: 476 DPLRTALEPEGGVYVDILPR 495
R L P V + L R
Sbjct: 512 --ARIVLVPNKKVGLQFLQR 529
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 79.8 bits (188), Expect = 2e-14
Identities = 109/457 (23%), Positives = 194/457 (42%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V +Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERTQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + + FL ++I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIF-GPT-VNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L+ +R ++ P +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNPQEINAYIGHSVE--KHRETLDPSAPRD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ +K K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEKEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 78.6 bits (185), Expect = 5e-14
Identities = 47/156 (30%), Positives = 86/156 (55%), Gaps = 4/156 (2%)
Query: 308 TLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN 367
+L + LY+L+++ +Q++L++EI++VL + E + M YL+ E++R+ P
Sbjct: 333 SLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE-EDLRNMPYLKACLKESMRLTPGVP 391
Query: 368 TLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA 427
R+ L+ T+ G + + KGT++++ E + + +F PER+ E K +
Sbjct: 392 FTTRT-LDKATVLG-EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-NP 448
Query: 428 CAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
A L FG+G R CIG RLA+LQ + + + KY +
Sbjct: 449 FAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 484
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 78.2 bits (184), Expect = 6e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 77.8 bits (183), Expect = 8e-14
Identities = 96/404 (23%), Positives = 169/404 (41%), Gaps = 28/404 (6%)
Query: 71 VVGMFRMTSPTLIVRDLDIV--KQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAV 128
+VG ++ LI + D Q+ D A N +GI F+ G L A A A
Sbjct: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA- 133
Query: 129 RSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSF 188
+F G K + +++ Q D + + N+ +++ +
Sbjct: 134 ------LFKDGDQK-LEKIICQEISTLSDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186
Query: 189 SMETDINDMQVYEMLNVAVFEN-SYISELDMV-----FPG-ILRKTNRSIFGPTVNNFCY 241
S + ++ V + N + +N S S +D+V FP L K + N+
Sbjct: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV--KIRNDLLN 244
Query: 242 EIVEFIKNE-RNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E K + R+ N D + M +N D + + H++ + F A
Sbjct: 245 KILENYKEKFRSDSITNMLDTL-MQAKMNSDNGNAGPDQDSELLSDNHILT-TIGDIFGA 302
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G T + ++L L + ++++L EI+ + + T+ N + LE E L
Sbjct: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVL 361
Query: 361 RMHPTTNTL-QRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERF-- 417
R+ P L A D +I + ++KGT V+I A HH+EK + +P++F PERF
Sbjct: 362 RLRPVAPMLIPHKANVDSSIG--EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419
Query: 418 SVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ ++L FG GPR+CIG LA+ + + M L ++
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 77.8 bits (183), Expect = 8e-14
Identities = 95/372 (25%), Positives = 160/372 (43%), Gaps = 36/372 (9%)
Query: 86 DLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHADADAWKAVRSHLTPMFSSGKLKNMV 145
D D +K I+ + K + KF +G L + W R LTP F + LK V
Sbjct: 101 DPDYMKVILGRSDPK-SHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYV 159
Query: 146 RVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACSFS----METDIND---MQ 198
+++ + +D + E+ + TIM +FS ++ D N +Q
Sbjct: 160 GLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219
Query: 199 VYEMLNVAVF---ENSYISELDMVFP--GILRKTNRSIFGPTVNNFCYEIVEFIKNE--R 251
LN VF N++ E D ++ R T+R+ + ++++ K + +
Sbjct: 220 AISDLNSLVFCCMRNAF-HENDTIYSLTSAGRWTHRAC--QLAHQHTDQVIQLRKAQLQK 276
Query: 252 NG-----KPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNT 306
G K D +D+LL KM+NGS +++ + +V F G+
Sbjct: 277 EGELEKIKRKRHLDFLDILL-----LAKMENGSI----LSDKDLRAEVDTFMFEGHDTTA 327
Query: 307 ITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTT 366
+++ LY LA QER EI +L + ++ T +++M Y M E LR++P
Sbjct: 328 SGISWILYALATHPKHQERCREEIHGLLGDGASI-TWNHLDQMPYTTMCIKEALRLYPPV 386
Query: 367 NTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRH 426
+ R T P + KG +VL+ HH+ K++P E FDP RF+ + ++H
Sbjct: 387 PGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGS--AQH 443
Query: 427 ACAFLSFGIGPR 438
+ AFL F G R
Sbjct: 444 SHAFLPFSGGSR 455
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 77.4 bits (182), Expect = 1e-13
Identities = 108/457 (23%), Positives = 191/457 (41%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + FL ++I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDPTFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIFG--PTVNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L+ +R ++ +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE--KHRETLDPSAPRD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ +K K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEKEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 77.0 bits (181), Expect = 1e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVR 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrome
P450IIE1 (ethanol-inducible) gene, complete cds. ).
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrome
P-450j mRNA, complete cds. ).
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1
protein.
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1
protein.
Length = 493
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468
>AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1
protein.
Length = 462
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 266 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 324
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 325 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 381
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+++ + + L + + P KD
Sbjct: 382 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 437
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 76.2 bits (179), Expect = 3e-13
Identities = 108/457 (23%), Positives = 190/457 (41%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + FL +I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIFG--PTVNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L+ +R ++ +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE--KHRETLDPSAPKD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ +K K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEKEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 76.2 bits (179), Expect = 3e-13
Identities = 108/457 (23%), Positives = 190/457 (41%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + FL +I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIFG--PTVNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L+ +R ++ +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE--KHRETLDPSAPKD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ +K K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEKEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 76.2 bits (179), Expect = 3e-13
Identities = 108/457 (23%), Positives = 190/457 (41%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + FL +I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIFG--PTVNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L+ +R ++ +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE--KHRETLDPSAPKD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ +K K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEKEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein.
Length = 521
Score = 75.8 bits (178), Expect = 3e-13
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 4/165 (2%)
Query: 299 AAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLE 358
A G ++TL + LY +A++ +Q+ L E+ + + + L+ E
Sbjct: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT-MLQLVPLLKASIKE 383
Query: 359 TLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFS 418
TLR+HP + TLQR + D + D I TLV + A + + +PE FDP R+
Sbjct: 384 TLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW- 440
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ K+ L FG G R C+G R+A+L+ + ++ L +RV
Sbjct: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485
>M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc
protein.
Length = 239
Score = 75.8 bits (178), Expect = 3e-13
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 4/165 (2%)
Query: 299 AAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLE 358
A G ++TL + LY +A++ +Q+ L E+ + + + L+ E
Sbjct: 43 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT-MLQLVPLLKASIKE 101
Query: 359 TLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFS 418
TLR+HP + TLQR + D + D I TLV + A + + +PE FDP R+
Sbjct: 102 TLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW- 158
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ K+ L FG G R C+G R+A+L+ + ++ L +RV
Sbjct: 159 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 203
>M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein.
Length = 521
Score = 75.8 bits (178), Expect = 3e-13
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 4/165 (2%)
Query: 299 AAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLE 358
A G ++TL + LY +A++ +Q+ L E+ + + + L+ E
Sbjct: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT-MLQLVPLLKASIKE 383
Query: 359 TLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFS 418
TLR+HP + TLQR + D + D I TLV + A + + +PE FDP R+
Sbjct: 384 TLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW- 440
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ K+ L FG G R C+G R+A+L+ + ++ L +RV
Sbjct: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485
>BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family
11, subfamily A, polypeptide 1 protein.
Length = 521
Score = 75.8 bits (178), Expect = 3e-13
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 4/165 (2%)
Query: 299 AAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLE 358
A G ++TL + LY +A++ +Q+ L E+ + + + L+ E
Sbjct: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT-MLQLVPLLKASIKE 383
Query: 359 TLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFS 418
TLR+HP + TLQR + D + D I TLV + A + + +PE FDP R+
Sbjct: 384 TLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW- 440
Query: 419 VENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ K+ L FG G R C+G R+A+L+ + ++ L +RV
Sbjct: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 75.4 bits (177), Expect = 4e-13
Identities = 45/144 (31%), Positives = 70/144 (48%), Gaps = 4/144 (2%)
Query: 297 FFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIF 356
F G+ +++ LY LA QER EI +L + ++ T +++M Y M
Sbjct: 2 FMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASI-TWNHLDQMPYTTMCI 60
Query: 357 LETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPER 416
E LR++P + R T P + KG V++ HH+ K++P PE FDP R
Sbjct: 61 KEALRLYPPVPGISRELSTPVTFPDGR-SLPKGITVMLSIYGLHHNPKVWPNPEVFDPSR 119
Query: 417 FSVENHKSRHACAFLSFGIGPRTC 440
F+ + ++H+ AFL F G R C
Sbjct: 120 FAPGS--AQHSHAFLPFSGGSRNC 141
>BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 75.4 bits (177), Expect = 4e-13
Identities = 54/176 (30%), Positives = 84/176 (47%), Gaps = 6/176 (3%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG + TL + L L K I+E+L EI+ V+ + + ++ EM Y++ +
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVH 355
Query: 358 ETLRMHPTT-NTLQRSALEDYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPE 415
E R + L A D G I KGT+V +P L + +D + +P+PEKF PE
Sbjct: 356 EIQRFITLVPSNLPHEATRDTIFRG--YLIPKGTVV-VPTLDSVLYDNQEFPDPEKFKPE 412
Query: 416 RFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
F EN K +++ F F G R C G LA+ + + + L + + P KD
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARTELFLLLCAILQHFNLKPLVDPKD 468
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 74.1 bits (174), Expect = 1e-12
Identities = 59/222 (26%), Positives = 94/222 (42%), Gaps = 8/222 (3%)
Query: 243 IVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAG 301
I+E +K + N D +D L + +K K SE +E E+ F AG
Sbjct: 137 ILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLENTAVD----LFGAG 191
Query: 302 YVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLR 361
+ TL ++L L K + ++ EIE V+ N ++ + M Y + + E R
Sbjct: 192 TETTSTTLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQR 250
Query: 362 MHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVEN 421
T A+ I + I KGT +LI + HD K +P PE FDP F E
Sbjct: 251 CIDLLPTSLPHAVT-CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEG 309
Query: 422 HKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRV 463
+ + F+ F G R C+G LA ++ + + L + +
Sbjct: 310 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 351
>BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family
51, subfamily A, polypeptide 1 protein.
Length = 509
Score = 74.1 bits (174), Expect = 1e-12
Identities = 47/177 (26%), Positives = 82/177 (46%), Gaps = 2/177 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T+ +AG + AG ++ T + + LA+D+++Q++ E +TV + LT +
Sbjct: 302 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 361
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ +++ L+ ETLR+ P + R A T+ G I G V + P +
Sbjct: 362 QLKDLNLLDRCIKETLRLRPPVMIMMRMARTPQTVAG--YTIPPGHQVCVSPTVNQRLKD 419
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ E F+P+R+ +N S A++ FG G CIG A +Q K L Y
Sbjct: 420 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476
>U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha
demethylase protein.
Length = 503
Score = 73.7 bits (173), Expect = 1e-12
Identities = 47/177 (26%), Positives = 82/177 (46%), Gaps = 2/177 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T+ +AG + AG ++ T + + LA+D+++Q++ E +TV + LT +
Sbjct: 296 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 355
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ +++ L+ ETLR+ P + R A T+ G I G V + P +
Sbjct: 356 QLKDLNLLDRCIRETLRLRPPIMIMMRMARTPQTVAG--YTIPPGHQVCVSPTVNQRLKD 413
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ E F+P+R+ +N S A++ FG G CIG A +Q K L Y
Sbjct: 414 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 470
>U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase
cytochrome P450 protein.
Length = 509
Score = 73.7 bits (173), Expect = 1e-12
Identities = 47/177 (26%), Positives = 82/177 (46%), Gaps = 2/177 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T+ +AG + AG ++ T + + LA+D+++Q++ E +TV + LT +
Sbjct: 302 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 361
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ +++ L+ ETLR+ P + R A T+ G I G V + P +
Sbjct: 362 QLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAG--YTIPPGHQVCVSPTVNQRLKD 419
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ E F+P+R+ +N S A++ FG G CIG A +Q K L Y
Sbjct: 420 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476
>D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase
protein.
Length = 509
Score = 73.7 bits (173), Expect = 1e-12
Identities = 47/177 (26%), Positives = 82/177 (46%), Gaps = 2/177 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T+ +AG + AG ++ T + + LA+D+++Q++ E +TV + LT +
Sbjct: 302 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 361
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ +++ L+ ETLR+ P + R A T+ G I G V + P +
Sbjct: 362 QLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAG--YTIPPGHQVCVSPTVNQRLKD 419
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ E F+P+R+ +N S A++ FG G CIG A +Q K L Y
Sbjct: 420 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476
>AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein.
Length = 509
Score = 73.7 bits (173), Expect = 1e-12
Identities = 47/177 (26%), Positives = 82/177 (46%), Gaps = 2/177 (1%)
Query: 285 ITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLE 344
+T+ +AG + AG ++ T + + LA+D+++Q++ E +TV + LT +
Sbjct: 302 LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYD 361
Query: 345 AINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEK 404
+ +++ L+ ETLR+ P + R A T+ G I G V + P +
Sbjct: 362 QLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAG--YTIPPGHQVCVSPTVNQRLKD 419
Query: 405 IYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKY 461
+ E F+P+R+ +N S A++ FG G CIG A +Q K L Y
Sbjct: 420 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 73.3 bits (172), Expect = 2e-12
Identities = 107/457 (23%), Positives = 189/457 (41%), Gaps = 42/457 (9%)
Query: 35 GPEPEFLFGNLKESFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIM 94
GP P L GNL + R+ + F ++Y D V + P +++ ++ +++ +
Sbjct: 33 GPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHLG--PRPVVMLCGVEAIREAL 88
Query: 95 IKDYAKFNERGIKFSKEGL--GDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLSQT 151
+ F+ RG + G + A+ + WK +R +T M G K V Q
Sbjct: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148
Query: 152 GDRFVDHVTNEVRLRPEQELVSLFLKYNIATIMACS--FSMETDINDMQVYEMLNVAVFE 209
+ + E+R + FL +I + CS F D + +MLN+
Sbjct: 149 EAQCL---IEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205
Query: 210 NSYIS----ELDMVFPGILRK---TNRSIFG--PTVNNFCYEIVEFIKNERNGKPANRND 260
S IS +L +F G L +R ++ +N + VE K+ P+ D
Sbjct: 206 FSLISSVFGQLFELFSGFLTYFPGAHRQVYKNLQEINAYIGHSVE--KHRETLDPSAPKD 263
Query: 261 MMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQ 320
++D L ++ ++ K N +F +++ + +FFA +T TL + + K
Sbjct: 264 LIDTYL-LHMEEEK-SNAHSEFSH--QNLNLNTLSLFFAGTETTST-TLRYGFLLMLKYP 318
Query: 321 SIQERLMREIETVLENHNNVLTLEAINEMSYLEMI------FLETLRMHPTTNTLQRSAL 374
+ ER+ REIE V+ H L +M Y E + F + L M Q ++
Sbjct: 319 HVAERVYREIEQVIGPHRPP-ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377
Query: 375 EDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
Y IP D E+ L+L L HD + +P+ F+P+ F N + AF+ F
Sbjct: 378 RGYIIP-KDTEV---FLILSTAL---HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+G R C+G +A+ + + L + +A +D
Sbjct: 431 LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 73.3 bits (172), Expect = 2e-12
Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 6/197 (3%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TL++++Y LA+ +Q+ + REI L +V T + ++ + + ET
Sbjct: 180 AGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNL-GERHVPTAADVPKVPLVRALLKET 238
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P R ED I G I KGT + + A + ++ +P ++F PER+
Sbjct: 239 LRLFPVLPGNGRVTQEDLVIGG--YLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR 296
Query: 420 ENHKSR-HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPL 478
+ R + FG G R+CIG R+A+L+ + +++ L + + S++T +
Sbjct: 297 KGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHA--KT 354
Query: 479 RTALEPEGGVYVDILPR 495
L P G ++V + R
Sbjct: 355 HGLLTPGGPIHVRFVNR 371
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 73.3 bits (172), Expect = 2e-12
Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 6/197 (3%)
Query: 300 AGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLET 359
AG + TL++++Y LA+ +Q+ + REI L +V T + ++ + + ET
Sbjct: 180 AGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL-GERHVPTAADVPKVPLVRALLKET 238
Query: 360 LRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSV 419
LR+ P R ED I G I KGT + + A + ++ +P ++F PER+
Sbjct: 239 LRLFPVLPGNGRVTQEDLVIGG--YLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR 296
Query: 420 ENHKSR-HACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPL 478
+ R + FG G R+CIG R+A+L+ + +++ L + + S++T +
Sbjct: 297 KGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHA--KT 354
Query: 479 RTALEPEGGVYVDILPR 495
L P G ++V + R
Sbjct: 355 HGLLTPGGPIHVRFVNR 371
>AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 22 protein.
Length = 421
Score = 72.9 bits (171), Expect = 2e-12
Identities = 44/145 (30%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Query: 346 INEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKI 405
+++M Y M E LR++P + R T P + KG +VL+ HH+ K+
Sbjct: 268 LDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKV 326
Query: 406 YPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAP 465
+P E FDP RF+ + ++H+ AFL F G R CIG + A Q KV L ++ + P
Sbjct: 327 WPNLEVFDPSRFAPGS--AQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 384
Query: 466 STRTKDAYKIDPLRTALEPEGGVYV 490
I R L+ + G+++
Sbjct: 385 D---PTRIPIPMARLVLKSKNGIHL 406
>X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSLVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETVAR 464
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 71.7 bits (168), Expect = 5e-12
Identities = 66/263 (25%), Positives = 113/263 (42%), Gaps = 14/263 (5%)
Query: 210 NSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANR-NDMMDMLLGV 268
N++ + +D FPG K +++ T+ ++ ++E IK + N D +D L +
Sbjct: 97 NNFSTIIDY-FPGSHNKLLKNLL--TLKSY---VLERIKEHQESLDMNNPRDFIDCFL-I 149
Query: 269 NCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMR 328
++ K SE VE + V F AG + TL ++L L K + ++
Sbjct: 150 KMEQEKHNQQSEFTVES----LIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQE 205
Query: 329 EIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIEIEK 388
EIE V+ N ++ + M Y + + E R T A+ + + I K
Sbjct: 206 EIERVV-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLIPTSLPHAVT-CDVKFRNYLIPK 263
Query: 389 GTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIGIRLAKL 448
GT +L + HD K +P PE FDP F E + + F+ F G R C+G LA++
Sbjct: 264 GTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARM 323
Query: 449 QYKVCMVKFLTKYRVAPSTRTKD 471
+ + + L + + KD
Sbjct: 324 ELFLFLTFILQNFNLKSLIDPKD 346
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 71.7 bits (168), Expect = 5e-12
Identities = 97/459 (21%), Positives = 179/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 71.7 bits (168), Expect = 5e-12
Identities = 97/459 (21%), Positives = 179/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 71.7 bits (168), Expect = 5e-12
Identities = 97/459 (21%), Positives = 179/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 71.7 bits (168), Expect = 5e-12
Identities = 97/459 (21%), Positives = 179/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1
variant protein.
Length = 484
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 252 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 308
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 309 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 367
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 368 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 425
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 426 KRKCIGETIAR 436
>AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1
protein.
Length = 251
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 19 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 75
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 76 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 134
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 135 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 192
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 193 KRKCIGETIAR 203
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 71.7 bits (168), Expect = 5e-12
Identities = 97/459 (21%), Positives = 179/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein.
Length = 512
Score = 71.7 bits (168), Expect = 5e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein.
Length = 512
Score = 71.3 bits (167), Expect = 7e-12
Identities = 49/191 (25%), Positives = 92/191 (48%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T +++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + +HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETVAR 464
>AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 70.9 bits (166), Expect = 9e-12
Identities = 66/212 (31%), Positives = 102/212 (48%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G N TL++++ L
Sbjct: 255 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTENTANTLSWAVVFLLH 309
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 370 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 422
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 423 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 454
>BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family
26, subfamily B, polypeptide 1 protein.
Length = 512
Score = 70.5 bits (165), Expect = 1e-11
Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 14/226 (6%)
Query: 273 LKMKNGSEDFVEIT-EHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
L +++ E E+T + + G + + FAA Y T + L K ++ E+L E+
Sbjct: 269 LLIESSKEHGKEMTMQELKDGTLELIFAA-YATTASASTSLIMQLLKHPTVLEKLRDELR 327
Query: 332 T--VLENHN----NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIE 385
+L + L L+ ++ + YL+ + E +R+ + R+ L+ + + G +
Sbjct: 328 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG--FQ 385
Query: 386 IEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA-CAFLSFGIGPRTCIGIR 444
I KG V+ H ++ + FDP+RFS + + +L FG G RTC+G
Sbjct: 386 IPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKH 445
Query: 445 LAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYV 490
LAKL KV V+ + R +TRT + P+ L P G+ V
Sbjct: 446 LAKLFLKVLAVELASTSRFELATRTFPRITLVPV---LHPVDGLSV 488
>BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family
26, subfamily B, polypeptide 1 protein.
Length = 512
Score = 70.5 bits (165), Expect = 1e-11
Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 14/226 (6%)
Query: 273 LKMKNGSEDFVEIT-EHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
L +++ E E+T + + G + + FAA Y T + L K ++ E+L E+
Sbjct: 269 LLIESSKEHGKEMTMQELKDGTLELIFAA-YATTASASTSLIMQLLKHPTVLEKLRDELR 327
Query: 332 T--VLENHN----NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIE 385
+L + L L+ ++ + YL+ + E +R+ + R+ L+ + + G +
Sbjct: 328 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG--FQ 385
Query: 386 IEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA-CAFLSFGIGPRTCIGIR 444
I KG V+ H ++ + FDP+RFS + + +L FG G RTC+G
Sbjct: 386 IPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKH 445
Query: 445 LAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYV 490
LAKL KV V+ + R +TRT + P+ L P G+ V
Sbjct: 446 LAKLFLKVLAVELASTSRFELATRTFPRITLVPV---LHPVDGLSV 488
>AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoid
metabolizing protein P450RAI-2 protein.
Length = 512
Score = 70.5 bits (165), Expect = 1e-11
Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 14/226 (6%)
Query: 273 LKMKNGSEDFVEIT-EHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
L +++ E E+T + + G + + FAA Y T + L K ++ E+L E+
Sbjct: 269 LLIESSKEHGKEMTMQELKDGTLELIFAA-YATTASASTSLIMQLLKHPTVLEKLRDELR 327
Query: 332 T--VLENHN----NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIE 385
+L + L L+ ++ + YL+ + E +R+ + R+ L+ + + G +
Sbjct: 328 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG--FQ 385
Query: 386 IEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA-CAFLSFGIGPRTCIGIR 444
I KG V+ H ++ + FDP+RFS + + +L FG G RTC+G
Sbjct: 386 IPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKH 445
Query: 445 LAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYV 490
LAKL KV V+ + R +TRT + P+ L P G+ V
Sbjct: 446 LAKLFLKVLAVELASTSRFELATRTFPRITLVPV---LHPVDGLSV 488
>AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein.
Length = 512
Score = 70.5 bits (165), Expect = 1e-11
Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 14/226 (6%)
Query: 273 LKMKNGSEDFVEIT-EHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIE 331
L +++ E E+T + + G + + FAA Y T + L K ++ E+L E+
Sbjct: 269 LLIESSKEHGKEMTMQELKDGTLELIFAA-YATTASASTSLIMQLLKHPTVLEKLRDELR 327
Query: 332 T--VLENHN----NVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGTDIE 385
+L + L L+ ++ + YL+ + E +R+ + R+ L+ + + G +
Sbjct: 328 AHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG--FQ 385
Query: 386 IEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHA-CAFLSFGIGPRTCIGIR 444
I KG V+ H ++ + FDP+RFS + + +L FG G RTC+G
Sbjct: 386 IPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKH 445
Query: 445 LAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTALEPEGGVYV 490
LAKL KV V+ + R +TRT + P+ L P G+ V
Sbjct: 446 LAKLFLKVLAVELASTSRFELATRTFPRITLVPV---LHPVDGLSV 488
>M12079-1|AAA52152.1| 191|Homo sapiens POR protein.
Length = 191
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 6/168 (3%)
Query: 283 VEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLT 342
V++++ + V F AG+ T +++SL +L + +Q ++ E++TV+ +
Sbjct: 6 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI-GRSRRPR 64
Query: 343 LEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHH 401
L + + Y+E LET R T+ S D ++ G I KG V + +H
Sbjct: 65 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKG--FYIPKGRCVFVNQWQINH 122
Query: 402 DEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIGPRTCIGIRLAK 447
D+K++ P +F PERF + + + FG+G R CIG +A+
Sbjct: 123 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVAR 170
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 70.1 bits (164), Expect = 2e-11
Identities = 97/459 (21%), Positives = 178/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFFGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KGT ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSKVDPKD-IDITPIANA 475
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 69.7 bits (163), Expect = 2e-11
Identities = 47/154 (30%), Positives = 75/154 (48%), Gaps = 7/154 (4%)
Query: 298 FAAGYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFL 357
F AG+ T +++SL +L IQ ++ +E++TV+ L ++ YLE L
Sbjct: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP-RLSDRPQLPYLEAFIL 373
Query: 358 ETLRMHP-TTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPER 416
ET R P T+ S D T+ G I K V + +HD +++ +P +F PER
Sbjct: 374 ETFRHSPFLPFTIPHSTTRDTTLNG--FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPER 431
Query: 417 FSVENHKSRH---ACAFLSFGIGPRTCIGIRLAK 447
F + + + + + FG+G R CIG LAK
Sbjct: 432 FLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465
>AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 69.7 bits (163), Expect = 2e-11
Identities = 49/191 (25%), Positives = 90/191 (47%), Gaps = 9/191 (4%)
Query: 260 DMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKD 319
D+ D L+ +C + ++ + V++++ + V F AG+ T ++SL +L +
Sbjct: 280 DITDSLIE-HCQEKQLDENAN--VQLSDEKIINIVLDLFGAGFDTVTTATSWSLMYLVMN 336
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHP-TTNTLQRSALEDYT 378
+Q ++ E++TV+ + L + + Y+E LET R T+ S D +
Sbjct: 337 PRVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395
Query: 379 IPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACA--FLSFGIG 436
+ G I KG V + HD+K++ P +F PERF + + + FG+G
Sbjct: 396 LKG--FYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453
Query: 437 PRTCIGIRLAK 447
R CIG +A+
Sbjct: 454 KRKCIGETIAR 464
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 58/231 (25%), Positives = 94/231 (40%), Gaps = 8/231 (3%)
Query: 242 EIVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E +K + N D +D L + +K K SE +E A A
Sbjct: 243 DILEKVKEHQESMDINNPRDFIDCFL-IKMEKEKQNQQSEFTIENLVITAAD----LLGA 297
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G + TL ++L L K + ++ EIE V+ N ++ M Y + + E
Sbjct: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI-GRNRSPCMQDRGHMPYTDAVVHEVQ 356
Query: 361 RMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVE 420
R T A+ + + I KGT +L + HD K +P PE FDP F E
Sbjct: 357 RYIDLIPTSLPHAVT-CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 415
Query: 421 NHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+ + F+ F G R C+G LA+++ + + L + + KD
Sbjct: 416 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 69.3 bits (162), Expect = 3e-11
Identities = 96/459 (20%), Positives = 178/459 (38%), Gaps = 25/459 (5%)
Query: 34 AGPEPEFLFGNLKE-SFHRRKHIATVFKEIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQ 92
+GP P + GN+ + T F ++Y V ++ P +++ + VK+
Sbjct: 31 SGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP-----VFTVYFGLKPIVVLHGYEAVKE 85
Query: 93 IMIKDYAKFNERGI--KFSKEGLGDNLFHADADAWKAVRSH-LTPMFSSGKLKNMVRVLS 149
+I +F+ RG K G + ++ WK +R L + + G K +
Sbjct: 86 ALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRV 145
Query: 150 QTGDRFVDHVTNEVRLRP-EQELVSLFLKYNIATIMACSFSMETDINDMQVYEML----- 203
Q R + + P + + N+ I + F D D + ++
Sbjct: 146 QEEARCLVEELRKTNASPCDPTFILGCAPCNV--ICSVIFHDRFDYKDQRFLNLMEKFNE 203
Query: 204 NVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFCYEIVEFIKNERNGKPANRNDMMD 263
N+ + + +I + FP ++ S NF Y I ++ ER + DM
Sbjct: 204 NLRILSSPWIQVCNN-FPALIDYLPGS-HNKIAENFAY-IKSYVL-ERIKEHQESLDMNS 259
Query: 264 MLLGVNCDKLKMKNGSEDFV-EITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAKDQSI 322
++C +KM+ + E T + V F AG + TL + L L K +
Sbjct: 260 ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEV 319
Query: 323 QERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTIPGT 382
++ EIE V+ N ++ + M Y + + E R T A+ +
Sbjct: 320 TAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVT-CDVKFK 377
Query: 383 DIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG 442
+ I KG ++ + H++K +P PE FDP F ++ + + F+ F G R C+G
Sbjct: 378 NYLIPKGMTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437
Query: 443 IRLAKLQYKVCMVKFLTKYRVAPSTRTKDAYKIDPLRTA 481
LA+++ + + L + + KD I P+ A
Sbjct: 438 EGLARMELFLFLTTILQNFNLKSQVDPKD-IDITPIANA 475
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 69.3 bits (162), Expect = 3e-11
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 2/137 (1%)
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
Q ++E L + N +N L +E + ++ Y+ + ETLR++P R AL+ + +
Sbjct: 255 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 314
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G +I KG V+ H +I+ E+F+P+RF + + + +F+ FG G R+
Sbjct: 315 NG--YQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRS 372
Query: 440 CIGIRLAKLQYKVCMVK 456
C+G AK+ K+ V+
Sbjct: 373 CVGKEFAKILLKIFTVE 389
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 69.3 bits (162), Expect = 3e-11
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 2/137 (1%)
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
Q ++E L + N +N L +E + ++ Y+ + ETLR++P R AL+ + +
Sbjct: 324 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G +I KG V+ H +I+ E+F+P+RF + + + +F+ FG G R+
Sbjct: 384 NG--YQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRS 441
Query: 440 CIGIRLAKLQYKVCMVK 456
C+G AK+ K+ V+
Sbjct: 442 CVGKEFAKILLKIFTVE 458
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 69.3 bits (162), Expect = 3e-11
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 2/137 (1%)
Query: 320 QSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETLRMHPTTNTLQRSALEDYTI 379
Q ++E L + N +N L +E + ++ Y+ + ETLR++P R AL+ + +
Sbjct: 324 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 383
Query: 380 PGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRT 439
G +I KG V+ H +I+ E+F+P+RF + + + +F+ FG G R+
Sbjct: 384 NG--YQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRS 441
Query: 440 CIGIRLAKLQYKVCMVK 456
C+G AK+ K+ V+
Sbjct: 442 CVGKEFAKILLKIFTVE 458
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 68.9 bits (161), Expect = 4e-11
Identities = 58/231 (25%), Positives = 94/231 (40%), Gaps = 8/231 (3%)
Query: 242 EIVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E +K + N D +D L + +K K SE +E A A
Sbjct: 221 DILEKVKEHQESMDINNPRDFIDCFL-IKMEKEKQNQQSEFTIENLVITAAD----LLGA 275
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G + TL ++L L K + ++ EIE V+ N ++ M Y + + E
Sbjct: 276 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVV-GRNRSPCMQDRGHMPYTDAVVHEVQ 334
Query: 361 RMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVE 420
R T A+ + + I KGT +L + HD K +P PE FDP F E
Sbjct: 335 RYIDLIPTSLPHAVT-CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 393
Query: 421 NHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+ + F+ F G R C+G LA+++ + + L + + KD
Sbjct: 394 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 444
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 68.9 bits (161), Expect = 4e-11
Identities = 58/231 (25%), Positives = 94/231 (40%), Gaps = 8/231 (3%)
Query: 242 EIVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E +K + N D +D L + +K K SE +E A A
Sbjct: 243 DILEKVKEHQESMDINNPRDFIDCFL-IKMEKEKQNQQSEFTIENLVITAAD----LLGA 297
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G + TL ++L L K + ++ EIE V+ N ++ M Y + + E
Sbjct: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVV-GRNRSPCMQDRGHMPYTDAVVHEVQ 356
Query: 361 RMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVE 420
R T A+ + + I KGT +L + HD K +P PE FDP F E
Sbjct: 357 RYIDLIPTSLPHAVT-CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 415
Query: 421 NHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+ + F+ F G R C+G LA+++ + + L + + KD
Sbjct: 416 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 68.9 bits (161), Expect = 4e-11
Identities = 58/231 (25%), Positives = 94/231 (40%), Gaps = 8/231 (3%)
Query: 242 EIVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E +K + N D +D L + +K K SE +E A A
Sbjct: 243 DILEKVKEHQESMDINNPRDFIDCFL-IKMEKEKQNQQSEFTIENLVITAAD----LLGA 297
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G + TL ++L L K + ++ EIE V+ N ++ M Y + + E
Sbjct: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVV-GRNRSPCMQDRGHMPYTDAVVHEVQ 356
Query: 361 RMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVE 420
R T A+ + + I KGT +L + HD K +P PE FDP F E
Sbjct: 357 RYIDLIPTSLPHAVT-CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 415
Query: 421 NHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+ + F+ F G R C+G LA+++ + + L + + KD
Sbjct: 416 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 68.9 bits (161), Expect = 4e-11
Identities = 58/231 (25%), Positives = 94/231 (40%), Gaps = 8/231 (3%)
Query: 242 EIVEFIKNERNGKPANR-NDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAA 300
+I+E +K + N D +D L + +K K SE +E A A
Sbjct: 243 DILEKVKEHQESMDINNPRDFIDCFL-IKMEKEKQNQQSEFTIENLVITAAD----LLGA 297
Query: 301 GYVNNTITLTFSLYHLAKDQSIQERLMREIETVLENHNNVLTLEAINEMSYLEMIFLETL 360
G + TL ++L L K + ++ EIE V+ N ++ M Y + + E
Sbjct: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVV-GRNRSPCMQDRGHMPYTDAVVHEVQ 356
Query: 361 RMHPTTNTLQRSALEDYTIPGTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVE 420
R T A+ + + I KGT +L + HD K +P PE FDP F E
Sbjct: 357 RYIDLIPTSLPHAVT-CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 415
Query: 421 NHKSRHACAFLSFGIGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPSTRTKD 471
+ + F+ F G R C+G LA+++ + + L + + KD
Sbjct: 416 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 256 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 310
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 371 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 423
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 424 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 255 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 309
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 370 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 422
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 423 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 454
>BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 464
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 225 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 279
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 280 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 339
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 340 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 392
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 393 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 424
>BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 255 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 309
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 370 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 422
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 423 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 454
>BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 255 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 309
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 370 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 422
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 423 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 454
>BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 68.5 bits (160), Expect = 5e-11
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 17/212 (8%)
Query: 260 DMMD-MLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAGYVNNTITLTFSLYHLAK 318
DMMD ML GV + M+ GS +E H+ A + + G TL++++ L
Sbjct: 256 DMMDYMLQGVA--QPSMEEGSGQLLEGHVHMAAVDLLI---GGTETTANTLSWAVVFLLH 310
Query: 319 DQSIQERLMREIETVLEN--HNNVLTLEAINEMSYLEMIFLETLRMHPTTN-TLQRSALE 375
IQ+RL E++ L ++ + + + L E LR+ P L
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370
Query: 376 DYTIPGTDIEIEKGTLVLIPPL-AFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFG 434
+I G DI +GT V+IP L H DE ++ P +F P+RF +E K+ A L+FG
Sbjct: 371 PSSISGYDIP--EGT-VIIPNLQGAHLDETVWERPHEFWPDRF-LEPGKNSRA---LAFG 423
Query: 435 IGPRTCIGIRLAKLQYKVCMVKFLTKYRVAPS 466
G R C+G LA+L+ V + + L + + PS
Sbjct: 424 CGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.323 0.138 0.402
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 66,629,305
Number of Sequences: 224733
Number of extensions: 2643844
Number of successful extensions: 5452
Number of sequences better than 10.0: 452
Number of HSP's better than 10.0 without gapping: 341
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 4446
Number of HSP's gapped (non-prelim): 528
length of query: 496
length of database: 73,234,838
effective HSP length: 93
effective length of query: 403
effective length of database: 52,334,669
effective search space: 21090871607
effective search space used: 21090871607
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 67 (31.1 bits)
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