Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001557-TA|BGIBMGA001557-PA|IPR005821|Ion transport,
IPR010526|Sodium ion transport-associated, IPR001696|Na+ channel,
IPR002048|Calcium-binding EF-hand
(1969 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF327246-2|AAG53413.1| 2005|Homo sapiens voltage-gated sodium ch... 984 0.0
AF327246-1|AAG53412.1| 2005|Homo sapiens voltage-gated sodium ch... 984 0.0
AC011303-1|AAY14971.1| 2005|Homo sapiens unknown protein. 984 0.0
M94055-1|AAA18895.1| 2005|Homo sapiens voltage-gated sodium chan... 982 0.0
M77235-1|AAA58644.1| 2016|Homo sapiens sodium channel alpha subu... 979 0.0
AB158469-1|BAD12084.1| 2016|Homo sapiens TTX-resistant sodium ch... 974 0.0
M81758-1|AAA60554.1| 1836|Homo sapiens sodium channel alpha subu... 842 0.0
AY212253-1|AAO83647.1| 1836|Homo sapiens skeletal muscle voltage... 842 0.0
L01983-1|AAA75557.1| 1835|Homo sapiens sodium channel alpha subu... 839 0.0
L04236-1|AAB59624.1| 1836|Homo sapiens skeletal muscle sodium ch... 838 0.0
AJ251507-1|CAB85895.1| 1951|Homo sapiens type III sodium channel... 835 0.0
AF330135-2|AAG53415.1| 1951|Homo sapiens voltage-gated sodium ch... 835 0.0
AF330135-1|AAG53414.1| 1951|Homo sapiens voltage-gated sodium ch... 835 0.0
AC013463-1|AAY15072.1| 2000|Homo sapiens unknown protein. 835 0.0
EF179185-1|ABN05288.1| 2015|Homo sapiens sodium channel, voltage... 831 0.0
AY148488-1|AAN61120.1| 2015|Homo sapiens cardiac sodium channel ... 831 0.0
AY038064-1|AAK74065.1| 2015|Homo sapiens voltage-gated sodium ch... 831 0.0
AF482988-1|AAO91669.1| 2015|Homo sapiens cardiac sodium channel ... 831 0.0
AF225988-1|AAF35390.1| 1980|Homo sapiens voltage-gated sodium ch... 831 0.0
AB027567-1|BAA78033.1| 1980|Homo sapiens sodium channel protein. 831 0.0
AF050736-1|AAD15789.1| 1980|Homo sapiens voltage-gated sodium ch... 830 0.0
DQ784809-1|ABQ01244.1| 2016|Homo sapiens sodium channel protein ... 828 0.0
AF225987-1|AAK00219.1| 2000|Homo sapiens voltage-gated sodium ch... 827 0.0
AF225986-1|AAK00218.1| 1951|Homo sapiens voltage-gated sodium ch... 827 0.0
AB158470-1|BAD12085.1| 1962|Homo sapiens TTX-resistant sodium ch... 826 0.0
X82835-1|CAA58042.1| 1977|Homo sapiens sodium channel alpha subu... 825 0.0
DQ857292-1|ABI51981.1| 1977|Homo sapiens voltage-gated sodium ch... 825 0.0
AY043484-1|AAK95360.1| 1998|Homo sapiens voltage-gated sodium ch... 819 0.0
AF225985-1|AAK00217.1| 1999|Homo sapiens voltage-gated sodium ch... 819 0.0
AC010127-1|AAX81984.1| 1998|Homo sapiens unknown protein. 819 0.0
AB098335-1|BAC45228.1| 1981|Homo sapiens Voltage-gated sodium ch... 819 0.0
AB093549-1|BAC21102.1| 1998|Homo sapiens Voltage-gated sodium ch... 819 0.0
AB093548-1|BAC21101.1| 2009|Homo sapiens voltage-gated sodium ch... 819 0.0
AF117907-1|AAD30863.1| 1956|Homo sapiens tetrodotoxin-resistant ... 802 0.0
AB208866-1|BAD92103.1| 1576|Homo sapiens voltage-gated sodium ch... 784 0.0
AJ417790-1|CAD10507.1| 1791|Homo sapiens voltage-gated sodium ch... 756 0.0
AF188679-1|AAF17480.1| 1791|Homo sapiens voltage-gated sodium ch... 756 0.0
AF109737-1|AAF24976.1| 1791|Homo sapiens voltage-gated sodium ch... 756 0.0
M91556-1|AAA59899.1| 1682|Homo sapiens Na+ channel protein. 596 e-169
AB037777-1|BAA92594.1| 519|Homo sapiens KIAA1356 protein protein. 487 e-136
AF150882-1|AAF24980.1| 1444|Homo sapiens voltage-gated sodium ch... 471 e-131
X65362-1|CAA46439.1| 423|Homo sapiens sodium channel protein. 450 e-125
AB208888-1|BAD92125.1| 1315|Homo sapiens Sodium channel protein ... 438 e-121
AF035686-1|AAC29515.1| 1366|Homo sapiens voltage-gated sodium ch... 427 e-118
AF035685-1|AAC29514.1| 1366|Homo sapiens voltage-gated sodium ch... 424 e-117
AC108146-1|AAY14794.1| 1146|Homo sapiens unknown protein. 412 e-114
L29385-1|AAA59205.1| 2270|Homo sapiens voltage-dependent calcium... 329 7e-89
L29384-1|AAA59204.1| 2251|Homo sapiens voltage-dependent calcium... 329 7e-89
L27745-1|AAA72125.1| 2312|Homo sapiens voltage-operated calcium ... 329 7e-89
AL590998-3|CAI22327.1| 2270|Homo sapiens calcium channel, voltag... 329 7e-89
AL590998-2|CAI22329.1| 2313|Homo sapiens calcium channel, voltag... 329 7e-89
AL590998-1|CAI22328.1| 2251|Homo sapiens calcium channel, voltag... 329 7e-89
AL359270-3|CAI14653.1| 2270|Homo sapiens calcium channel, voltag... 329 7e-89
AL359270-2|CAI14655.1| 2313|Homo sapiens calcium channel, voltag... 329 7e-89
AL359270-1|CAI14654.1| 2251|Homo sapiens calcium channel, voltag... 329 7e-89
AL161734-3|CAH72676.1| 2313|Homo sapiens calcium channel, voltag... 329 7e-89
AL161734-2|CAH72677.1| 2251|Homo sapiens calcium channel, voltag... 329 7e-89
AL161734-1|CAH72675.1| 2270|Homo sapiens calcium channel, voltag... 329 7e-89
AL160059-3|CAI17083.1| 2270|Homo sapiens calcium channel, voltag... 329 7e-89
AL160059-2|CAI17082.1| 2313|Homo sapiens calcium channel, voltag... 329 7e-89
AL160059-1|CAI17081.1| 2251|Homo sapiens calcium channel, voltag... 329 7e-89
AF223391-1|AAF37687.1| 2224|Homo sapiens calcium channel alpha1E... 329 7e-89
AB209499-1|BAD92736.1| 1869|Homo sapiens calcium channel, voltag... 329 7e-89
AB037525-1|BAA90445.1| 364|Homo sapiens voltage-gated sodium ch... 328 2e-88
Z34812-1|CAA84343.1| 2146|Homo sapiens voltage-dependent L-type ... 326 6e-88
L29529-1|AAA51899.1| 2169|Homo sapiens L-type voltage-dependent ... 326 6e-88
AY830711-1|AAX37354.1| 2144|Homo sapiens voltage-dependent L-typ... 325 1e-87
Z34816-1|CAA84347.1| 2138|Homo sapiens voltage-dependent L-type ... 324 3e-87
L29536-1|AAA51901.1| 2109|Homo sapiens calcium channel L-type al... 324 3e-87
L29534-1|AAA51900.1| 2144|Homo sapiens cardiac L-type voltage-de... 324 3e-87
L04569-1|AAA02501.1| 2180|Homo sapiens L-type voltage-dependent ... 324 3e-87
AY830712-1|AAX37355.1| 2157|Homo sapiens voltage-dependent L-typ... 324 3e-87
AL358473-3|CAI12387.1| 1854|Homo sapiens calcium channel, voltag... 324 3e-87
AL139159-2|CAI23206.1| 1854|Homo sapiens calcium channel, voltag... 324 3e-87
AF223391-2|AAF37688.1| 2162|Homo sapiens calcium channel alpha1E... 323 4e-87
U79666-1|AAB64179.1| 2505|Homo sapiens alpha1A-voltage-dependent... 322 6e-87
AB035726-1|BAA94765.1| 2472|Homo sapiens alpha1A-voltage-depende... 322 1e-86
M94173-1|AAA51898.1| 2237|Homo sapiens N-type calcium channel al... 320 2e-86
M94172-1|AAA51897.1| 2339|Homo sapiens N-type calcium channel al... 320 2e-86
AL772363-4|CAI17144.1| 2339|Homo sapiens calcium channel, voltag... 320 2e-86
AL772363-1|CAI17141.1| 2237|Homo sapiens calcium channel, voltag... 320 2e-86
AL591424-2|CAI40687.1| 2339|Homo sapiens calcium channel, voltag... 320 2e-86
AL591424-1|CAI40685.1| 2237|Homo sapiens calcium channel, voltag... 320 2e-86
X99897-1|CAA68172.1| 2262|Homo sapiens calcium channel alpha1 su... 320 4e-86
DQ363527-1|ABC88010.1| 1088|Homo sapiens low-voltage-activated c... 320 4e-86
DQ363526-1|ABC88009.1| 1077|Homo sapiens low-voltage-activated c... 320 4e-86
Z34814-1|CAA84345.1| 2127|Homo sapiens voltage-dependent L-type ... 319 6e-86
Z34813-1|CAA84344.1| 2146|Homo sapiens voltage-dependent L-type ... 319 6e-86
Z34811-1|CAA84342.1| 2157|Homo sapiens voltage-dependent L-type ... 319 6e-86
Z34810-1|CAA84341.1| 2138|Homo sapiens voltage-dependent L-type ... 319 6e-86
DQ494460-1|ABF69911.1| 2314|Homo sapiens T calcium channel alpha... 319 6e-86
DQ494459-1|ABF69910.1| 2266|Homo sapiens T calcium channel alpha... 319 6e-86
DQ494450-1|ABF69901.1| 2243|Homo sapiens T calcium channel alpha... 319 6e-86
AY682083-1|AAT85832.1| 542|Homo sapiens voltage-gated sodium ch... 319 6e-86
AL772363-3|CAI17143.1| 2338|Homo sapiens calcium channel, voltag... 319 6e-86
AL772363-2|CAI17142.1| 2337|Homo sapiens calcium channel, voltag... 319 6e-86
AL591424-4|CAI40686.1| 2338|Homo sapiens calcium channel, voltag... 319 6e-86
AL591424-3|CAI40688.1| 2337|Homo sapiens calcium channel, voltag... 319 6e-86
AJ420779-1|CAD12646.1| 2347|Homo sapiens calcium channel, voltag... 319 6e-86
AF465484-1|AAM70049.1| 2138|Homo sapiens jejunum L-type calcium ... 319 6e-86
AF227751-1|AAF37696.1| 2266|Homo sapiens voltage-dependent calci... 319 6e-86
AF126965-1|AAD29400.1| 2243|Homo sapiens voltage-dependent calci... 319 6e-86
AB032949-1|BAA86437.2| 1717|Homo sapiens KIAA1123 protein protein. 319 6e-86
DQ494470-1|ABF69921.1| 2366|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494469-1|ABF69920.1| 2321|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494468-1|ABF69919.1| 2273|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494467-1|ABF69918.1| 2194|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494456-1|ABF69907.1| 2298|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494455-1|ABF69906.1| 2250|Homo sapiens T calcium channel alpha... 319 7e-86
DQ494454-1|ABF69905.1| 2171|Homo sapiens T calcium channel alpha... 319 7e-86
AY682081-1|AAT85830.1| 531|Homo sapiens voltage-gated sodium ch... 319 7e-86
AF227746-1|AAF37691.1| 2298|Homo sapiens voltage-dependent calci... 319 7e-86
AF227745-1|AAF37690.1| 2321|Homo sapiens voltage-dependent calci... 319 7e-86
AF227744-1|AAF37689.1| 2273|Homo sapiens voltage-dependent calci... 319 7e-86
AF190860-1|AAF35287.1| 2250|Homo sapiens low voltage-activated T... 319 7e-86
AF134985-1|AAF19346.1| 2171|Homo sapiens T calcium channel alpha... 319 7e-86
AF126966-1|AAD29401.1| 2250|Homo sapiens voltage-dependent calci... 319 7e-86
Z34809-1|CAA84340.1| 2138|Homo sapiens voltage-dependent L-type ... 317 2e-85
AY682082-1|AAT85831.1| 542|Homo sapiens voltage-gated sodium ch... 317 3e-85
AB209171-1|BAD92408.1| 1854|Homo sapiens calcium channel, voltag... 317 3e-85
AB209467-1|BAD92704.1| 1370|Homo sapiens calcium channel, voltag... 316 4e-85
D43747-1|BAA07804.1| 2170|Homo sapiens voltage-dependent calcium... 315 9e-85
AB035727-1|BAA94766.2| 2506|Homo sapiens alpha1A-voltage-depende... 315 9e-85
DQ363528-1|ABC88011.1| 1083|Homo sapiens low-voltage-activated c... 315 1e-84
AF223563-1|AAF60163.1| 1536|Homo sapiens low-voltage-activated c... 315 1e-84
AF073931-1|AAD17668.1| 2353|Homo sapiens low-voltage activated c... 315 1e-84
AF051946-1|AAC67239.3| 2353|Homo sapiens T-type calcium channel ... 315 1e-84
AE006466-3|AAK61268.1| 2373|Homo sapiens voltage dependent t-typ... 315 1e-84
AF004884-1|AAB61613.1| 2510|Homo sapiens neuronal calcium channe... 314 2e-84
AF004883-1|AAB61612.1| 2266|Homo sapiens neuronal calcium channe... 314 2e-84
DQ494465-1|ABF69916.1| 2332|Homo sapiens T calcium channel alpha... 314 2e-84
DQ494464-1|ABF69915.1| 2284|Homo sapiens T calcium channel alpha... 314 2e-84
DQ494463-1|ABF69914.1| 2205|Homo sapiens T calcium channel alpha... 314 2e-84
DQ494453-1|ABF69904.1| 2261|Homo sapiens T calcium channel alpha... 314 2e-84
BC110995-1|AAI10996.1| 2261|Homo sapiens calcium channel, voltag... 314 2e-84
AF227750-1|AAF37695.1| 2332|Homo sapiens voltage-dependent calci... 314 2e-84
AF227749-1|AAF37694.1| 2284|Homo sapiens voltage-dependent calci... 314 2e-84
AF227748-1|AAF37693.1| 2306|Homo sapiens voltage-dependent calci... 314 2e-84
AF227747-1|AAF37692.1| 2261|Homo sapiens voltage-dependent calci... 314 2e-84
AF134986-1|AAF19347.1| 2377|Homo sapiens T calcium channel alpha... 314 2e-84
M83566-1|AAA35629.1| 2181|Homo sapiens calcium channel alpha-1 s... 314 3e-84
AL022319-1|CAI19662.1| 2016|Homo sapiens calcium channel, voltag... 314 3e-84
AL022312-6|CAI19180.1| 2016|Homo sapiens calcium channel, voltag... 314 3e-84
AL008716-1|CAI17903.1| 2016|Homo sapiens calcium channel, voltag... 314 3e-84
AF393329-1|AAM67414.1| 2188|Homo sapiens voltage-dependent calci... 314 3e-84
AF211189-1|AAF44626.1| 1981|Homo sapiens T-type calcium channel ... 314 3e-84
AF142567-1|AAF25722.1| 2223|Homo sapiens T calcium channel alpha... 314 3e-84
AF129133-1|AAD45251.1| 2016|Homo sapiens T-type calcium channel ... 314 3e-84
DQ363529-1|ABC88012.1| 1099|Homo sapiens low-voltage-activated c... 313 4e-84
AY682086-1|AAT85835.1| 539|Homo sapiens voltage-gated sodium ch... 313 4e-84
AY682084-1|AAT85833.1| 528|Homo sapiens voltage-gated sodium ch... 313 4e-84
AJ224874-1|CAA12175.1| 1966|Homo sapiens L-type calcium channel ... 313 4e-84
AJ006216-1|CAA06916.1| 1966|Homo sapiens L-type calcium channel ... 313 4e-84
AF201304-1|AAF15290.1| 1977|Homo sapiens voltage-gated L-type ca... 313 4e-84
AF067227-1|AAD03587.1| 1912|Homo sapiens voltage-gated L-type ca... 313 4e-84
Z74996-1|CAA99284.1| 2157|Homo sapiens voltage-dependent L-type ... 313 5e-84
Z34822-1|CAA84353.1| 2173|Homo sapiens voltage-dependent L-type ... 313 5e-84
Z34817-1|CAA84348.1| 2139|Homo sapiens voltage-dependent L-type ... 313 5e-84
Z34815-1|CAA84346.1| 2138|Homo sapiens voltage-dependent L-type ... 313 5e-84
AJ224873-1|CAA12174.1| 2138|Homo sapiens voltage-dependent L-typ... 313 5e-84
M76558-1|AAA58402.1| 2161|Homo sapiens calcium channel alpha-1D ... 312 1e-83
DQ494471-1|ABF69922.1| 2291|Homo sapiens T calcium channel alpha... 309 8e-83
BC133671-1|AAI33672.1| 1873|Homo sapiens CACNA1S protein protein. 308 1e-82
AL358473-2|CAI12386.1| 1873|Homo sapiens calcium channel, voltag... 308 1e-82
AL139159-1|CAI23207.1| 1873|Homo sapiens calcium channel, voltag... 308 1e-82
AY682085-1|AAT85834.1| 539|Homo sapiens voltage-gated sodium ch... 307 2e-82
DQ494457-1|ABF69908.1| 2259|Homo sapiens T calcium channel alpha... 307 3e-82
L33798-1|AAA51902.1| 1873|Homo sapiens dihydropyridine-sensitive... 306 6e-82
Z34818-1|CAA84349.1| 2158|Homo sapiens voltage-dependent L-type ... 303 3e-81
AB032946-1|BAA86434.1| 1024|Homo sapiens KIAA1120 protein protein. 303 4e-81
Z34820-1|CAA84351.1| 2155|Homo sapiens voltage-dependent L-type ... 302 9e-81
DQ494461-1|ABF69912.1| 2277|Homo sapiens T calcium channel alpha... 301 1e-80
U30707-1|AAB37235.1| 1871|Homo sapiens dihydropyridine receptor ... 294 2e-78
DQ494477-1|ABF69928.1| 2248|Homo sapiens T calcium channel alpha... 286 6e-76
U79664-1|AAB49675.1| 949|Homo sapiens alpha1A-voltage-dependent... 276 5e-73
DQ494458-1|ABF69909.1| 1758|Homo sapiens T calcium channel alpha... 272 8e-72
DQ494449-1|ABF69900.1| 1735|Homo sapiens T calcium channel alpha... 272 8e-72
DQ494466-1|ABF69917.1| 1765|Homo sapiens T calcium channel alpha... 272 1e-71
U79668-1|AAB49678.1| 916|Homo sapiens alpha1A-voltage-dependent... 269 8e-71
U79667-1|AAB49677.1| 1182|Homo sapiens alpha1A-voltage-dependent... 269 8e-71
U79665-1|AAB49676.1| 1194|Homo sapiens alpha1A-voltage-sensitive... 269 8e-71
U79663-1|AAB49674.1| 949|Homo sapiens alpha1A-voltage-dependent... 269 8e-71
DQ494462-1|ABF69913.1| 1776|Homo sapiens T calcium channel alpha... 267 3e-70
DQ494452-1|ABF69903.1| 1753|Homo sapiens T calcium channel alpha... 267 3e-70
DQ494451-1|ABF69902.1| 1746|Homo sapiens T calcium channel alpha... 262 9e-69
AF049618-1|AAD20439.1| 324|Homo sapiens voltage-gated sodium ch... 254 2e-66
AF038871-1|AAG43105.1| 209|Homo sapiens type IV sodium channel ... 243 6e-63
Z34819-1|CAA84350.1| 2166|Homo sapiens voltage-dependent L-type ... 226 5e-58
AY830713-1|AAX37356.1| 2179|Homo sapiens voltage-dependent L-typ... 221 2e-56
AC005305-1|AAC26839.1| 419|Homo sapiens CACNL1A4 protein. 217 3e-55
Z26295-1|CAA81219.1| 683|Homo sapiens L-type Ca2+ channel isofo... 215 2e-54
Z34821-1|CAA84352.1| 2186|Homo sapiens voltage-dependent L-type ... 210 3e-53
M92269-1|AAA17030.1| 2221|Homo sapiens L-type calcium channel (H... 210 3e-53
X65361-1|CAA46438.1| 245|Homo sapiens brain type II sodium chan... 204 2e-51
AB209016-1|BAD92253.1| 840|Homo sapiens Voltage-dependent L-typ... 191 2e-47
BC051374-1|AAH51374.1| 223|Homo sapiens SCN5A protein protein. 187 4e-46
AJ310892-1|CAC84535.1| 156|Homo sapiens Nav1.5 protein. 185 1e-45
AJ310889-1|CAC84532.1| 156|Homo sapiens Nav1.5 protein. 185 1e-45
AJ310888-1|CAC84531.1| 156|Homo sapiens Nav1.5 protein. 185 1e-45
AJ310887-1|CAC84530.1| 156|Homo sapiens Nav1.5 protein. 185 1e-45
AJ310886-1|CAC84529.1| 156|Homo sapiens Nav1.5 protein. 185 1e-45
AJ310891-1|CAC84534.1| 156|Homo sapiens Nav1.5 protein. 182 1e-44
AJ310890-1|CAC84533.1| 156|Homo sapiens Nav1.5 protein. 182 1e-44
AJ277394-1|CAC03586.1| 121|Homo sapiens voltage-gated sodium ch... 178 2e-43
AJ276140-1|CAC03583.1| 121|Homo sapiens SCN3A protein. 178 2e-43
AJ276139-1|CAC03582.1| 121|Homo sapiens SCN3A protein. 178 2e-43
AF100774-1|AAC77460.1| 980|Homo sapiens voltage-dependent P/Q t... 175 1e-42
AJ310883-1|CAC84551.1| 115|Homo sapiens Nav1.7 protein. 167 3e-40
AJ310882-1|CAC84550.1| 115|Homo sapiens Nav1.7 protein. 167 3e-40
U93305-4|AAB92359.1| 644|Homo sapiens calcium channel alpha-1 s... 165 2e-39
AY141972-1|AAN10255.1| 1738|Homo sapiens putative 4 repeat volta... 165 2e-39
AL356778-1|CAI16648.1| 1738|Homo sapiens voltage gated channel l... 165 2e-39
AL354891-1|CAH73919.1| 1738|Homo sapiens voltage gated channel l... 165 2e-39
AL138707-1|CAI40711.1| 1738|Homo sapiens voltage gated channel l... 165 2e-39
AJ580918-1|CAE45644.1| 119|Homo sapiens voltage-gated sodium ch... 161 3e-38
AJ580919-1|CAE45645.1| 119|Homo sapiens voltage-gated sodium ch... 159 1e-37
DQ494478-1|ABF69929.1| 2246|Homo sapiens T calcium channel alpha... 156 9e-37
DQ494479-1|ABF69930.1| 2287|Homo sapiens T calcium channel alpha... 154 3e-36
DQ494476-1|ABF69927.1| 2239|Homo sapiens T calcium channel alpha... 154 3e-36
DQ494475-1|ABF69926.1| 2257|Homo sapiens T calcium channel alpha... 154 3e-36
DQ494474-1|ABF69925.1| 2250|Homo sapiens T calcium channel alpha... 154 3e-36
DQ494473-1|ABF69924.1| 2232|Homo sapiens T calcium channel alpha... 154 3e-36
DQ494472-1|ABF69923.1| 2227|Homo sapiens T calcium channel alpha... 154 3e-36
AF029228-1|AAD12731.1| 319|Homo sapiens T-type calcium channel ... 153 5e-36
EF092294-1|ABN50063.1| 128|Homo sapiens cardiac sodium channel ... 149 8e-35
M57972-1|AAB59461.1| 294|Homo sapiens cardiac L-type calcium ch... 133 5e-30
AB012043-1|BAA36409.1| 1555|Homo sapiens NBR13 protein. 130 5e-29
M57971-1|AAA62832.1| 294|Homo sapiens L-type calcium channel al... 129 1e-28
AJ310893-1|CAC84525.1| 113|Homo sapiens Nav1.5 protein. 118 3e-25
Z26294-1|CAA81218.1| 574|Homo sapiens L-type Ca2+ channel isofo... 113 5e-24
AF124351-1|AAD34352.1| 1207|Homo sapiens T-type calcium channel ... 105 2e-21
BC028390-1|AAH28390.1| 668|Homo sapiens VGCNL1 protein protein. 99 2e-19
S69887-1|AAB30530.1| 90|Homo sapiens SCN3A protein. 95 3e-18
S71446-1|AAB31605.1| 94|Homo sapiens brain type I sodium chann... 94 5e-18
EF092293-1|ABN50062.1| 102|Homo sapiens cardiac sodium channel ... 93 7e-18
EF092292-1|ABN50061.1| 98|Homo sapiens cardiac sodium channel ... 93 7e-18
M91370-1|AAA74590.1| 198|Homo sapiens voltage-gated calcium cha... 89 2e-16
AY686224-1|AAT95434.1| 153|Homo sapiens voltage-gated sodium ch... 87 6e-16
BC110384-1|AAI10385.1| 398|Homo sapiens cation channel, sperm a... 86 1e-15
BC101692-1|AAI01693.1| 398|Homo sapiens cation channel, sperm a... 86 1e-15
AF432876-1|AAO85416.1| 398|Homo sapiens putative one-repeat cal... 86 1e-15
AF239921-1|AAF44690.1| 82|Homo sapiens brain type III sodim ch... 85 3e-15
BC064387-1|AAH64387.1| 528|Homo sapiens cation channel, sperm a... 83 1e-14
AF411819-1|AAL26492.1| 414|Homo sapiens putative ion channel pr... 83 1e-14
AF411818-1|AAL26491.1| 530|Homo sapiens putative ion channel pr... 83 1e-14
AF411817-1|AAL26490.1| 528|Homo sapiens putative ion channel pr... 83 1e-14
AL591424-7|CAI40691.1| 164|Homo sapiens calcium channel, voltag... 82 2e-14
M55662-1|AAB65854.2| 70|Homo sapiens type II sodium channel al... 75 2e-12
AJ310885-1|CAC84528.1| 50|Homo sapiens Nav1.6 protein. 75 3e-12
AJ310884-1|CAC84527.1| 50|Homo sapiens Nav1.6 protein. 75 3e-12
AJ277395-1|CAC03587.1| 50|Homo sapiens voltage-gated sodium ch... 75 3e-12
AJ276142-1|CAC03585.1| 50|Homo sapiens hNa6/Scn8a voltage-gate... 75 3e-12
AJ276141-1|CAC03584.1| 50|Homo sapiens hNa6/Scn8a voltage-gate... 75 3e-12
DQ086162-1|AAZ06802.1| 58|Homo sapiens voltage-gated sodium ch... 70 1e-10
BC128139-1|AAI28140.1| 472|Homo sapiens cation channel, sperm a... 70 1e-10
AL355877-1|CAH71538.1| 426|Homo sapiens cation channel, sperm a... 70 1e-10
AL031703-1|CAC42094.1| 808|Homo sapiens c302G6.1 (calcium chann... 70 1e-10
AY083666-1|AAM01199.1| 816|Homo sapiens two-pore channel 1 prot... 67 5e-10
AB032995-1|BAA86483.2| 857|Homo sapiens KIAA1169 protein protein. 67 5e-10
BC036522-1|AAH36522.1| 780|Homo sapiens cation channel, sperm a... 66 9e-10
BC032950-1|AAH32950.1| 780|Homo sapiens cation channel, sperm a... 66 9e-10
AF407333-1|AAL14105.1| 780|Homo sapiens sperm ion channel protein. 66 9e-10
S82622-1|AAB21450.2| 35|Homo sapiens sodium channel alpha subu... 60 8e-08
BC128138-1|AAI28139.1| 373|Homo sapiens CATSPER4 protein protein. 58 2e-07
BC044801-1|AAH44801.1| 1129|Homo sapiens SLC9A10 protein protein. 58 3e-07
S76537-1|AAB33068.1| 115|Homo sapiens P-type voltage-gated calc... 57 6e-07
AK128084-1|BAC87265.1| 1177|Homo sapiens protein ( Homo sapiens ... 57 6e-07
X68302-1|CAA48374.1| 858|Homo sapiens h-DRK1 K(+) channel protein. 54 7e-06
L02840-1|AAA36156.1| 854|Homo sapiens voltage-gated potassium c... 54 7e-06
BC110573-1|AAI10574.1| 813|Homo sapiens KCNB1 protein protein. 54 7e-06
BC110572-1|AAI10573.1| 813|Homo sapiens KCNB1 protein protein. 54 7e-06
AL035685-1|CAB89417.1| 858|Homo sapiens potassium voltage-gated... 54 7e-06
AF059683-1|AAC14574.1| 89|Homo sapiens voltage-gated sodium ch... 54 7e-06
AF026005-1|AAB88808.1| 858|Homo sapiens delayed rectifier potas... 54 7e-06
DQ148960-1|AAZ77737.1| 46|Homo sapiens SCN9A protein. 53 9e-06
U69962-1|AAB08433.1| 806|Homo sapiens delayed rectifier potassi... 51 4e-05
AF450111-1|AAP46292.1| 911|Homo sapiens voltage-gated potassium... 51 4e-05
AF338730-1|AAK16585.1| 911|Homo sapiens potassium voltage-gated... 51 4e-05
L02752-1|AAA36141.1| 499|Homo sapiens potassium channel protein. 50 8e-05
S56770-1|AAB25764.1| 511|Homo sapiens voltage-gated potassium c... 49 2e-04
BC107129-1|AAI07130.1| 511|Homo sapiens potassium voltage-gated... 49 2e-04
BC063008-1|AAH63008.1| 752|Homo sapiens two pore segment channe... 48 3e-04
AY029200-1|AAK31802.1| 752|Homo sapiens two-pore calcium channe... 48 3e-04
AB209253-1|BAD92490.1| 458|Homo sapiens two pore segment channe... 48 3e-04
U09784-1|AAA20531.1| 101|Homo sapiens dihydropyridine receptor ... 48 3e-04
AK075071-1|BAC11385.1| 252|Homo sapiens protein ( Homo sapiens ... 48 3e-04
BC064343-1|AAH64343.1| 218|Homo sapiens VGCNL1 protein protein. 48 4e-04
AE014301-1|AAN16023.1| 266|Homo sapiens CanIon protein. 48 4e-04
AL137479-1|CAB70760.1| 371|Homo sapiens hypothetical protein pr... 46 0.001
AF120491-1|AAD38898.1| 655|Homo sapiens Sha1-related potassium ... 46 0.002
AF048713-1|AAC05122.1| 655|Homo sapiens Kv4.3 potassium channel... 46 0.002
AF048712-1|AAC05121.1| 636|Homo sapiens Kv4.3 potassium channel... 46 0.002
M64676-1|AAA57263.1| 582|Homo sapiens potassium channel protein... 45 0.002
BC113477-1|AAI13478.1| 636|Homo sapiens potassium voltage-gated... 45 0.003
BC113475-1|AAI13476.1| 636|Homo sapiens potassium voltage-gated... 45 0.003
BC026110-1|AAH26110.1| 494|Homo sapiens potassium voltage-gated... 45 0.003
AL512665-2|CAI16955.1| 636|Homo sapiens potassium voltage-gated... 45 0.003
AL512665-1|CAI16956.1| 655|Homo sapiens potassium voltage-gated... 45 0.003
AL450997-2|CAI19097.1| 636|Homo sapiens potassium voltage-gated... 45 0.003
AL450997-1|CAI19096.1| 655|Homo sapiens potassium voltage-gated... 45 0.003
AL049557-3|CAB55687.2| 636|Homo sapiens potassium voltage-gated... 45 0.003
AL049557-2|CAI22711.1| 655|Homo sapiens potassium voltage-gated... 45 0.003
AF205857-1|AAF20925.1| 655|Homo sapiens potassium ionic channel... 45 0.003
AF205856-1|AAF20924.1| 636|Homo sapiens potassium ionic channel... 45 0.003
AF187964-1|AAF01045.1| 636|Homo sapiens voltage gated potassium... 45 0.003
AF187963-1|AAF01044.1| 655|Homo sapiens voltage gated potassium... 45 0.003
AF166011-2|AAF68178.1| 636|Homo sapiens voltage-gated potassium... 45 0.003
AF166011-1|AAF68177.1| 655|Homo sapiens voltage-gated potassium... 45 0.003
AF033382-1|AAC05597.1| 494|Homo sapiens potassium channel protein. 45 0.003
AF029780-1|AAG43055.1| 494|Homo sapiens potassium channel protein. 45 0.003
AC019041-1|AAX81991.1| 494|Homo sapiens unknown protein. 45 0.003
AF223561-1|AAF60161.1| 100|Homo sapiens low-voltage-activated c... 44 0.006
BC101769-1|AAI01770.1| 582|Homo sapiens potassium voltage-gated... 44 0.007
AL137790-1|CAI18831.1| 635|Homo sapiens potassium voltage-gated... 44 0.007
M96747-1|AAA59458.1| 232|Homo sapiens type l voltage-gated K+ c... 43 0.013
BC101353-1|AAI01354.1| 545|Homo sapiens potassium channel, subf... 42 0.022
BC101352-1|AAI01353.1| 545|Homo sapiens potassium channel, subf... 42 0.022
BC032672-1|AAH32672.1| 273|Homo sapiens HVCN1 protein protein. 42 0.022
BC009731-1|AAH09731.1| 273|Homo sapiens hydrogen voltage-gated ... 42 0.022
BC007277-1|AAH07277.1| 236|Homo sapiens HVCN1 protein protein. 42 0.022
AL354723-2|CAI15124.1| 545|Homo sapiens potassium channel, subf... 42 0.022
AJ310897-1|CAC84537.1| 61|Homo sapiens Nav1.7 protein. 42 0.022
AF348983-1|AAL83910.1| 545|Homo sapiens voltage-gated potassium... 42 0.022
AB209994-1|BAE06076.1| 641|Homo sapiens KCNC2 variant protein p... 42 0.022
BC111991-1|AAI11992.1| 558|Homo sapiens Shaw-related voltage-ga... 42 0.029
BC093635-1|AAH93635.1| 558|Homo sapiens potassium voltage-gated... 42 0.029
AY243473-1|AAO89503.1| 629|Homo sapiens Kv3.2d voltage-gated po... 42 0.029
AY118169-1|AAM81577.1| 638|Homo sapiens potassium voltage-gated... 42 0.029
AK094720-1|BAC04407.1| 558|Homo sapiens protein ( Homo sapiens ... 42 0.029
AJ310896-1|CAC84536.1| 61|Homo sapiens Nav1.5 protein. 42 0.029
AF268897-1|AAL27273.1| 613|Homo sapiens voltage gated potassium... 42 0.029
AF268896-1|AAL27272.1| 638|Homo sapiens voltage gated potassium... 42 0.029
BC042592-1|AAH42592.1| 1124|Homo sapiens solute carrier family 9... 41 0.039
AL139142-3|CAI20938.1| 1124|Homo sapiens solute carrier family 9... 41 0.039
M55515-1|AAA36425.1| 523|Homo sapiens potassium channel protein... 41 0.052
M85217-1|AAA59457.1| 523|Homo sapiens potassium channel protein... 40 0.068
M38217-1|AAB88073.1| 523|Homo sapiens voltage-gated potassium c... 40 0.068
BC064595-1|AAH64595.1| 557|Homo sapiens Unknown (protein for IM... 40 0.068
BC035059-1|AAH35059.2| 575|Homo sapiens potassium voltage-gated... 40 0.068
AY779768-1|AAX11186.1| 456|Homo sapiens voltage-dependent potas... 40 0.068
AL365361-2|CAH71983.1| 575|Homo sapiens potassium voltage-gated... 40 0.068
AJ310479-1|CAC29065.1| 456|Homo sapiens potassium voltage-gated... 40 0.068
AF315818-1|AAK63002.1| 456|Homo sapiens voltage-gated potassium... 40 0.068
L02750-1|AAA36139.1| 495|Homo sapiens potassium channel protein. 39 0.16
BC112180-1|AAI12181.1| 495|Homo sapiens potassium voltage-gated... 39 0.16
BC101733-1|AAI01734.1| 495|Homo sapiens potassium voltage-gated... 39 0.16
Z11585-1|CAA77671.1| 361|Homo sapiens chromosome 19 potassium c... 39 0.21
L23499-1|AAC31761.1| 523|Homo sapiens potassium channel protein. 39 0.21
BC028728-1|AAH28728.1| 199|Homo sapiens cation channel, sperm a... 39 0.21
AF055989-1|AAC24118.1| 757|Homo sapiens Shaw type potassium cha... 39 0.21
AB208930-1|BAD92167.1| 428|Homo sapiens Shaw-related voltage-ga... 39 0.21
AF142568-1|AAD52159.1| 372|Homo sapiens voltage-gated potassium... 38 0.27
BC110450-1|AAI10451.1| 630|Homo sapiens potassium voltage-gated... 38 0.36
BC110449-1|AAI10450.1| 630|Homo sapiens potassium voltage-gated... 38 0.36
BC028739-1|AAH28739.1| 500|Homo sapiens potassium channel, subf... 38 0.36
AJ010969-1|CAB56841.1| 630|Homo sapiens potassium channel Kv4.2... 38 0.36
AF167082-1|AAD48031.2| 500|Homo sapiens neuronal potassium chan... 38 0.36
AF121104-1|AAD22053.1| 630|Homo sapiens potassium channel KV4.2... 38 0.36
AC092020-1|AAS07530.1| 372|Homo sapiens unknown protein. 38 0.36
AB032013-1|BAA92316.1| 500|Homo sapiens potassium channel Kv8.1... 38 0.36
AB028967-1|BAA82996.2| 646|Homo sapiens KIAA1044 protein protein. 38 0.36
BC004987-1|AAH04987.1| 491|Homo sapiens potassium voltage-gated... 37 0.63
BC004148-1|AAH04148.1| 491|Homo sapiens potassium voltage-gated... 37 0.63
AF166008-1|AAF65618.1| 630|Homo sapiens voltage-gated potassium... 37 0.63
Z93024-4|CAI18792.1| 2253|Homo sapiens polycystic kidney disease... 37 0.84
AL078611-3|CAI18766.1| 2253|Homo sapiens polycystic kidney disea... 37 0.84
AL031034-1|CAI18795.1| 2253|Homo sapiens polycystic kidney disea... 37 0.84
AF116458-1|AAD18021.1| 2253|Homo sapiens polycystic kidney disea... 37 0.84
DQ084244-1|AAZ31363.1| 758|Homo sapiens polycystic kidney disea... 36 1.1
BC028719-1|AAH28719.1| 533|Homo sapiens transmembrane phosphata... 36 1.1
BC025665-1|AAH25665.1| 805|Homo sapiens polycystic kidney disea... 36 1.1
AY219887-1|AAP45144.1| 513|Homo sapiens phosphatase TPTE gamma ... 36 1.1
AY219886-1|AAP45143.1| 533|Homo sapiens phosphatase TPTE beta i... 36 1.1
AL163201-1|CAB90528.1| 551|Homo sapiens tensin, putative protei... 36 1.1
AL139819-2|CAH72822.1| 805|Homo sapiens polycystic kidney disea... 36 1.1
AF495908-1|AAQ06674.1| 533|Homo sapiens BJ-HCC-5 protein. 36 1.1
AF153474-1|AAF28108.1| 805|Homo sapiens polycystic kidney disea... 36 1.1
AF094827-1|AAD08695.1| 710|Homo sapiens PKD2L protein. 36 1.1
AF092170-1|AAD16101.1| 665|Homo sapiens polycystic kidney disea... 36 1.1
AF073481-1|AAD41638.1| 805|Homo sapiens polycystin-L protein. 36 1.1
AF053316-1|AAD51859.1| 763|Homo sapiens polycystin-2 homolog pr... 36 1.1
AF007118-1|AAC34574.1| 551|Homo sapiens putative tyrosine phosp... 36 1.1
U96110-1|AAC51333.1| 511|Homo sapiens cyclic GMP gated potassiu... 36 1.5
M60450-1|AAA61275.1| 653|Homo sapiens voltage-gated potassium c... 36 1.5
M55514-1|AAA60034.1| 653|Homo sapiens potassium channel protein... 36 1.5
L02751-1|AAA36140.1| 653|Homo sapiens potassium channel protein. 36 1.5
BC074990-1|AAH74990.1| 511|Homo sapiens potassium voltage-gated... 36 1.5
BC015947-1|AAH15947.1| 491|Homo sapiens potassium voltage-gated... 36 1.5
AL358215-3|CAH74103.1| 511|Homo sapiens potassium voltage-gated... 36 1.5
AJ310898-1|CAC84538.1| 62|Homo sapiens Nav1.6 protein. 36 1.5
AF043472-1|AAC13164.1| 491|Homo sapiens Shab-related delayed-re... 36 1.5
AC093731-1|AAX88969.1| 491|Homo sapiens unknown protein. 36 1.5
BC045659-1|AAH45659.1| 647|Homo sapiens potassium voltage-gated... 36 1.9
AJ005898-1|CAA06755.1| 647|Homo sapiens shal-type potassium cha... 36 1.9
AF166006-1|AAF65617.1| 647|Homo sapiens voltage-gated potassium... 36 1.9
AF166003-1|AAF65516.1| 647|Homo sapiens voltage-gated potassium... 36 1.9
AB021865-1|BAA96454.1| 647|Homo sapiens shal-type potassium cha... 36 1.9
U56813-1|AAC50933.1| 608|Homo sapiens polycystwin protein. 35 2.6
U50928-1|AAC50520.1| 968|Homo sapiens PKD2 protein. 35 2.6
BC112263-1|AAI12264.1| 968|Homo sapiens polycystin 2 protein. 35 2.6
BC112261-1|AAI12262.1| 968|Homo sapiens polycystin 2 protein. 35 2.6
AY359054-1|AAQ89413.1| 255|Homo sapiens ATWD578 protein. 35 2.6
AF004873-1|AAC16004.1| 968|Homo sapiens autosomal dominant poly... 35 2.6
BC132687-1|AAI32688.1| 383|Homo sapiens NPAL2 protein protein. 35 3.4
AK024017-1|BAB14779.1| 368|Homo sapiens protein ( Homo sapiens ... 35 3.4
Z93016-3|CAB07507.2| 526|Homo sapiens potassium voltage-gated c... 34 4.5
X17622-1|CAA35623.1| 529|Homo sapiens protein ( Human HBK2 mRNA... 34 4.5
M83254-1|AAA60146.1| 585|Homo sapiens potassium channel protein. 34 4.5
M60451-1|AAA61276.1| 611|Homo sapiens voltage-gated potassium c... 34 4.5
M55513-1|AAA36422.1| 613|Homo sapiens potassium channel protein... 34 4.5
BC132959-1|AAI32960.1| 526|Homo sapiens KCNS1 protein protein. 34 4.5
BC132957-1|AAI32958.1| 526|Homo sapiens KCNS1 protein protein. 34 4.5
BC099666-1|AAH99666.3| 613|Homo sapiens potassium voltage-gated... 34 4.5
BC099665-1|AAH99665.3| 613|Homo sapiens potassium voltage-gated... 34 4.5
BC096358-1|AAH96358.3| 613|Homo sapiens potassium voltage-gated... 34 4.5
BC096357-1|AAH96357.1| 613|Homo sapiens potassium voltage-gated... 34 4.5
BC075034-1|AAH75034.2| 526|Homo sapiens potassium voltage-gated... 34 4.5
BC075033-1|AAH75033.2| 526|Homo sapiens potassium voltage-gated... 34 4.5
BC069355-1|AAH69355.1| 529|Homo sapiens potassium voltage-gated... 34 4.5
AF182034-1|AAF65622.1| 624|Homo sapiens polycystic kidney disea... 34 4.5
AF118125-1|AAD46478.1| 609|Homo sapiens polycystin-2-like prote... 34 4.5
AF043473-1|AAC13165.2| 526|Homo sapiens delayed-rectifier K+ ch... 34 4.5
BC034778-1|AAH34778.1| 477|Homo sapiens potassium voltage-gated... 34 5.9
BC027932-1|AAH27932.1| 477|Homo sapiens potassium voltage-gated... 34 5.9
AB032970-1|BAA86458.1| 489|Homo sapiens KIAA1144 protein protein. 34 5.9
>AF327246-2|AAG53413.1| 2005|Homo sapiens voltage-gated sodium channel
type II alpha subunit protein.
Length = 2005
Score = 984 bits (2435), Expect = 0.0
Identities = 518/1104 (46%), Positives = 713/1104 (64%), Gaps = 59/1104 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM V G C+ F+ +V
Sbjct: 909 ECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMV 968
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A R+ + ID++KR + +F+
Sbjct: 969 IGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFI--- 1025
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
Q A ++ +E++ DL++ KD + + + IG + N K
Sbjct: 1026 ------QKAFVRKQKALDEIKPLEDLNNK---KDSCISNHTTIEIGKDL-------NYLK 1069
Query: 1065 KGKILMNNINAITDNHRDNRLDCE--LNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKG 1122
G + I + + + + D +N+ + + + + + F ES
Sbjct: 1070 DGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES--- 1126
Query: 1123 SADTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGADEDVVDDTPADCCP 1182
D + +EK +A+ G+ +V +E + P C
Sbjct: 1127 --DMEESKEKLNATSSSEGSTVDIGAPAE--------GEQP-EVEPEESL---EPEACFT 1172
Query: 1183 EQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHL 1242
E C +KF + + W LR +K++E+ +FET ++ MILLSS ALA ED+++
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI 1232
Query: 1243 PHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA 1302
R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV VSL++ A
Sbjct: 1233 EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTAN 1292
Query: 1303 LCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFA 1362
G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLIFWLIF+
Sbjct: 1293 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query: 1363 IMGVQLFAGKYFKCVDMNHTT---LSHEIIPDKNACTL---ENYT--WENSPMNFDHVGK 1414
IMGV LFAGK++ C+ N+TT ++ + + C N T W+N +NFD+VG
Sbjct: 1353 IMGVNLFAGKFYHCI--NYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL 1410
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
YL L QVATFKGW+ IM A+DSR V QP E N+YMYLY TLNLFIG
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 1475 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVT 1534
VIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +VF+ VT
Sbjct: 1471 VIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT 1529
Query: 1535 DKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHY 1594
+ FD+ IM+ I LNM+TM ++ QS+ + +L ++N++FIV+F+ EC+LK+ +LRY+Y
Sbjct: 1530 KQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYY 1589
Query: 1595 FVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTL 1654
F WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGAKGIRTL
Sbjct: 1590 FTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1649
Query: 1655 LFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQ 1714
LFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF SMI LFQ
Sbjct: 1650 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQ 1709
Query: 1715 MSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVIN 1770
++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++ISFL+V+N
Sbjct: 1710 ITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVN 1769
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
MYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF D L+PPL
Sbjct: 1770 MYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPL 1829
Query: 1831 QIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRPE 1886
I KPNK ++I+MD+P+ GD + C+DIL A TK G I+ P
Sbjct: 1830 LIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPS 1889
Query: 1887 EAGYEPVSSTLWRQREEYCARLIQ 1910
+ YEP+++TL R++EE A +IQ
Sbjct: 1890 KVSYEPITTTLKRKQEEVSAIIIQ 1913
Score = 438 bits (1079), Expect = e-121
Identities = 231/426 (54%), Positives = 296/426 (69%), Gaps = 45/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL K+ + E+K + E GP+P++ LE G LP
Sbjct: 14 FRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDE---------NGPKPNSDLEAGKSLPF 64
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK I RFSAT AL+IL PFNPIR++AI
Sbjct: 65 -IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LF++ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW-------------GN 301
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P++ S+ GN
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 302 LTD-------ENWERFCQNETNWYG-EG-GDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
T NW+ + ++++++Y EG D LCGNSS AGQC GY+C++ G NPNY
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNY 362
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA
Sbjct: 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 423 VVAMAY 428
Score = 104 bits (250), Expect = 3e-21
Identities = 86/287 (29%), Positives = 150/287 (52%), Gaps = 37/287 (12%)
Query: 1520 RPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
+P + + +V +V D D+ I + I LN L M ++HY +E FS+VL N++F IF
Sbjct: 743 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K
Sbjct: 855 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D + T
Sbjct: 915 SNDCELPRWHMHDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQT 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+ +T + +VI L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1000
Score = 79.4 bits (187), Expect = 1e-13
Identities = 38/99 (38%), Positives = 58/99 (58%), Gaps = 3/99 (3%)
Query: 733 SRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLV 792
SR ++++ T E+ E+ ++K C K + +WDCC WL+ + V L+V
Sbjct: 700 SRQRAMSIASILTNTMEELEES---RQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVV 756
Query: 793 FDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 757 MDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN 795
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/187 (25%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ +W P+ ++ + +++ P L I I++N + M M P E
Sbjct: 730 YKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 789
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + +G+ ++
Sbjct: 790 VLSVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG 845
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 904
Query: 284 VLTQKCV 290
++CV
Sbjct: 905 KSYKECV 911
Score = 77.8 bits (183), Expect = 4e-13
Identities = 68/290 (23%), Positives = 137/290 (47%), Gaps = 30/290 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINYTT 1371
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
+ ++ + E E+N + + ++ G GY+ L +
Sbjct: 1372 GEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL-----GYLSLLQVATFKGW-- 1424
Query: 355 TSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y +NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1425 --MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Score = 76.2 bits (179), Expect = 1e-12
Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM +K +A
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIA 812
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IV +SL+ G ++ +R+ R LR + +
Sbjct: 813 MDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVEGLSVLRSFRLLRVFKLAKSWPTL 867
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 911
Score = 72.9 bits (171), Expect = 1e-11
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 11/135 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF ++ + +V G + A +T
Sbjct: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSALRT 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 1374 FKCVDMNHTTLSHEI 1388
KC+ S EI
Sbjct: 276 NKCLQWPPDNSSFEI 290
Score = 56.0 bits (129), Expect = 1e-06
Identities = 44/166 (26%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+ +I+ F+M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 174
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 175 LARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 225
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 271
Score = 41.1 bits (92), Expect = 0.039
Identities = 36/169 (21%), Positives = 78/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTP-TVESTEV------IFTGIYT 178
P N + + + +F + I+ I +N + M++ T + E T + +F ++T
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ + Y WN DFVV+ L+ V M + +R
Sbjct: 1576 GECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
Score = 39.5 bits (88), Expect = 0.12
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1577 ECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1636
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1637 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1691
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1692 D-DMFNFETFGNSMICLFQI 1710
>AF327246-1|AAG53412.1| 2005|Homo sapiens voltage-gated sodium channel
type II alpha subunit protein.
Length = 2005
Score = 984 bits (2435), Expect = 0.0
Identities = 518/1104 (46%), Positives = 713/1104 (64%), Gaps = 59/1104 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM V G C+ F+ +V
Sbjct: 909 ECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMV 968
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A R+ + ID++KR + +F+
Sbjct: 969 IGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFI--- 1025
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
Q A ++ +E++ DL++ KD + + + IG + N K
Sbjct: 1026 ------QKAFVRKQKALDEIKPLEDLNNK---KDSCISNHTTIEIGKDL-------NYLK 1069
Query: 1065 KGKILMNNINAITDNHRDNRLDCE--LNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKG 1122
G + I + + + + D +N+ + + + + + F ES
Sbjct: 1070 DGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES--- 1126
Query: 1123 SADTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGADEDVVDDTPADCCP 1182
D + +EK +A+ G+ +V +E + P C
Sbjct: 1127 --DMEESKEKLNATSSSEGSTVDIGAPAE--------GEQP-EVEPEESL---EPEACFT 1172
Query: 1183 EQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHL 1242
E C +KF + + W LR +K++E+ +FET ++ MILLSS ALA ED+++
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI 1232
Query: 1243 PHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA 1302
R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV VSL++ A
Sbjct: 1233 EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTAN 1292
Query: 1303 LCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFA 1362
G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLIFWLIF+
Sbjct: 1293 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query: 1363 IMGVQLFAGKYFKCVDMNHTT---LSHEIIPDKNACTL---ENYT--WENSPMNFDHVGK 1414
IMGV LFAGK++ C+ N+TT ++ + + C N T W+N +NFD+VG
Sbjct: 1353 IMGVNLFAGKFYHCI--NYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL 1410
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
YL L QVATFKGW+ IM A+DSR V QP E N+YMYLY TLNLFIG
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 1475 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVT 1534
VIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +VF+ VT
Sbjct: 1471 VIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT 1529
Query: 1535 DKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHY 1594
+ FD+ IM+ I LNM+TM ++ QS+ + +L ++N++FIV+F+ EC+LK+ +LRY+Y
Sbjct: 1530 KQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYY 1589
Query: 1595 FVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTL 1654
F WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGAKGIRTL
Sbjct: 1590 FTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1649
Query: 1655 LFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQ 1714
LFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF SMI LFQ
Sbjct: 1650 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQ 1709
Query: 1715 MSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVIN 1770
++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++ISFL+V+N
Sbjct: 1710 ITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVN 1769
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
MYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF D L+PPL
Sbjct: 1770 MYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPL 1829
Query: 1831 QIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRPE 1886
I KPNK ++I+MD+P+ GD + C+DIL A TK G I+ P
Sbjct: 1830 LIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPS 1889
Query: 1887 EAGYEPVSSTLWRQREEYCARLIQ 1910
+ YEP+++TL R++EE A +IQ
Sbjct: 1890 KVSYEPITTTLKRKQEEVSAIIIQ 1913
Score = 436 bits (1074), Expect = e-121
Identities = 230/426 (53%), Positives = 296/426 (69%), Gaps = 45/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL K+ + E+K + E GP+P++ LE G LP
Sbjct: 14 FRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDE---------NGPKPNSDLEAGKSLPF 64
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK I RFSAT AL+IL PFNPIR++AI
Sbjct: 65 -IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LF++ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW-------------GN 301
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P++ S+ GN
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 302 LTD-------ENWERFCQNETNWYG-EG-GDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
T NW+ + ++++++Y EG D LCGNSS AGQC GY+C++ G NPNY
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNY 362
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA
Sbjct: 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 423 VVAMAY 428
Score = 104 bits (250), Expect = 3e-21
Identities = 86/287 (29%), Positives = 150/287 (52%), Gaps = 37/287 (12%)
Query: 1520 RPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
+P + + +V +V D D+ I + I LN L M ++HY +E FS+VL N++F IF
Sbjct: 743 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K
Sbjct: 855 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D + T
Sbjct: 915 SNDCELPRWHMHDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQT 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+ +T + +VI L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1000
Score = 79.4 bits (187), Expect = 1e-13
Identities = 38/99 (38%), Positives = 58/99 (58%), Gaps = 3/99 (3%)
Query: 733 SRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLV 792
SR ++++ T E+ E+ ++K C K + +WDCC WL+ + V L+V
Sbjct: 700 SRQRAMSIASILTNTMEELEES---RQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVV 756
Query: 793 FDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 757 MDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN 795
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/187 (25%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ +W P+ ++ + +++ P L I I++N + M M P E
Sbjct: 730 YKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 789
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + +G+ ++
Sbjct: 790 VLSVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG 845
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 904
Query: 284 VLTQKCV 290
++CV
Sbjct: 905 KSYKECV 911
Score = 77.8 bits (183), Expect = 4e-13
Identities = 68/290 (23%), Positives = 137/290 (47%), Gaps = 30/290 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINYTT 1371
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
+ ++ + E E+N + + ++ G GY+ L +
Sbjct: 1372 GEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL-----GYLSLLQVATFKGW-- 1424
Query: 355 TSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y +NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1425 --MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Score = 76.2 bits (179), Expect = 1e-12
Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM +K +A
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIA 812
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IV +SL+ G ++ +R+ R LR + +
Sbjct: 813 MDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVEGLSVLRSFRLLRVFKLAKSWPTL 867
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 911
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 11/135 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF ++ + +V G + A +T
Sbjct: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVNLGNVSALRT 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 1374 FKCVDMNHTTLSHEI 1388
KC+ S EI
Sbjct: 276 NKCLQWPPDNSSFEI 290
Score = 56.4 bits (130), Expect = 1e-06
Identities = 44/166 (26%), Positives = 83/166 (50%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+ +I+ F+M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 174
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV+ + +R +V R L
Sbjct: 175 LARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVNLGNVSALRTFRVLRAL 225
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 271
Score = 41.1 bits (92), Expect = 0.039
Identities = 36/169 (21%), Positives = 78/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTP-TVESTEV------IFTGIYT 178
P N + + + +F + I+ I +N + M++ T + E T + +F ++T
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ + Y WN DFVV+ L+ V M + +R
Sbjct: 1576 GECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
Score = 39.5 bits (88), Expect = 0.12
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1577 ECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1636
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1637 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1691
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1692 D-DMFNFETFGNSMICLFQI 1710
>AC011303-1|AAY14971.1| 2005|Homo sapiens unknown protein.
Length = 2005
Score = 984 bits (2435), Expect = 0.0
Identities = 518/1104 (46%), Positives = 713/1104 (64%), Gaps = 59/1104 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM V G C+ F+ +V
Sbjct: 909 ECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMV 968
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A R+ + ID++KR + +F+
Sbjct: 969 IGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFI--- 1025
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
Q A ++ +E++ DL++ KD + + + IG + N K
Sbjct: 1026 ------QKAFVRKQKALDEIKPLEDLNNK---KDSCISNHTTIEIGKDL-------NYLK 1069
Query: 1065 KGKILMNNINAITDNHRDNRLDCE--LNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKG 1122
G + I + + + + D +N+ + + + + + F ES
Sbjct: 1070 DGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES--- 1126
Query: 1123 SADTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGADEDVVDDTPADCCP 1182
D + +EK +A+ G+ +V +E + P C
Sbjct: 1127 --DMEESKEKLNATSSSEGSTVDIGAPAE--------GEQP-EVEPEESL---EPEACFT 1172
Query: 1183 EQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHL 1242
E C +KF + + W LR +K++E+ +FET ++ MILLSS ALA ED+++
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI 1232
Query: 1243 PHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA 1302
R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV VSL++ A
Sbjct: 1233 EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTAN 1292
Query: 1303 LCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFA 1362
G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLIFWLIF+
Sbjct: 1293 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query: 1363 IMGVQLFAGKYFKCVDMNHTT---LSHEIIPDKNACTL---ENYT--WENSPMNFDHVGK 1414
IMGV LFAGK++ C+ N+TT ++ + + C N T W+N +NFD+VG
Sbjct: 1353 IMGVNLFAGKFYHCI--NYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL 1410
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
YL L QVATFKGW+ IM A+DSR V QP E N+YMYLY TLNLFIG
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 1475 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVT 1534
VIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +VF+ VT
Sbjct: 1471 VIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT 1529
Query: 1535 DKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHY 1594
+ FD+ IM+ I LNM+TM ++ QS+ + +L ++N++FIV+F+ EC+LK+ +LRY+Y
Sbjct: 1530 KQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYY 1589
Query: 1595 FVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTL 1654
F WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGAKGIRTL
Sbjct: 1590 FTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1649
Query: 1655 LFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQ 1714
LFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF SMI LFQ
Sbjct: 1650 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQ 1709
Query: 1715 MSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVIN 1770
++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++ISFL+V+N
Sbjct: 1710 ITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVN 1769
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
MYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF D L+PPL
Sbjct: 1770 MYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPL 1829
Query: 1831 QIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRPE 1886
I KPNK ++I+MD+P+ GD + C+DIL A TK G I+ P
Sbjct: 1830 LIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPS 1889
Query: 1887 EAGYEPVSSTLWRQREEYCARLIQ 1910
+ YEP+++TL R++EE A +IQ
Sbjct: 1890 KVSYEPITTTLKRKQEEVSAIIIQ 1913
Score = 438 bits (1079), Expect = e-121
Identities = 231/426 (54%), Positives = 296/426 (69%), Gaps = 45/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL K+ + E+K + E GP+P++ LE G LP
Sbjct: 14 FRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDE---------NGPKPNSDLEAGKSLPF 64
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK I RFSAT AL+IL PFNPIR++AI
Sbjct: 65 -IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LF++ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW-------------GN 301
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P++ S+ GN
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 302 LTD-------ENWERFCQNETNWYG-EG-GDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
T NW+ + ++++++Y EG D LCGNSS AGQC GY+C++ G NPNY
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNY 362
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA
Sbjct: 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 423 VVAMAY 428
Score = 104 bits (250), Expect = 3e-21
Identities = 86/287 (29%), Positives = 150/287 (52%), Gaps = 37/287 (12%)
Query: 1520 RPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
+P + + +V +V D D+ I + I LN L M ++HY +E FS+VL N++F IF
Sbjct: 743 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K
Sbjct: 855 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D + T
Sbjct: 915 SNDCELPRWHMHDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQT 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+ +T + +VI L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1000
Score = 79.4 bits (187), Expect = 1e-13
Identities = 38/99 (38%), Positives = 58/99 (58%), Gaps = 3/99 (3%)
Query: 733 SRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLV 792
SR ++++ T E+ E+ ++K C K + +WDCC WL+ + V L+V
Sbjct: 700 SRQRAMSIASILTNTMEELEES---RQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVV 756
Query: 793 FDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 757 MDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN 795
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/187 (25%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ +W P+ ++ + +++ P L I I++N + M M P E
Sbjct: 730 YKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 789
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + +G+ ++
Sbjct: 790 VLSVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG 845
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 904
Query: 284 VLTQKCV 290
++CV
Sbjct: 905 KSYKECV 911
Score = 77.8 bits (183), Expect = 4e-13
Identities = 68/290 (23%), Positives = 137/290 (47%), Gaps = 30/290 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINYTT 1371
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
+ ++ + E E+N + + ++ G GY+ L +
Sbjct: 1372 GEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL-----GYLSLLQVATFKGW-- 1424
Query: 355 TSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y +NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1425 --MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Score = 76.2 bits (179), Expect = 1e-12
Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM +K +A
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIA 812
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IV +SL+ G ++ +R+ R LR + +
Sbjct: 813 MDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVEGLSVLRSFRLLRVFKLAKSWPTL 867
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 911
Score = 72.9 bits (171), Expect = 1e-11
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 11/135 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF ++ + +V G + A +T
Sbjct: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSALRT 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 1374 FKCVDMNHTTLSHEI 1388
KC+ S EI
Sbjct: 276 NKCLQWPPDNSSFEI 290
Score = 56.0 bits (129), Expect = 1e-06
Identities = 44/166 (26%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+ +I+ F+M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 174
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 175 LARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 225
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 271
Score = 41.1 bits (92), Expect = 0.039
Identities = 36/169 (21%), Positives = 78/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTP-TVESTEV------IFTGIYT 178
P N + + + +F + I+ I +N + M++ T + E T + +F ++T
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ + Y WN DFVV+ L+ V M + +R
Sbjct: 1576 GECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
Score = 39.5 bits (88), Expect = 0.12
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1577 ECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1636
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1637 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1691
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1692 D-DMFNFETFGNSMICLFQI 1710
>M94055-1|AAA18895.1| 2005|Homo sapiens voltage-gated sodium channel
protein.
Length = 2005
Score = 982 bits (2430), Expect = 0.0
Identities = 517/1104 (46%), Positives = 712/1104 (64%), Gaps = 59/1104 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM V G C+ F+ +V
Sbjct: 909 ECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMV 968
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A R+ + ID++KR + +F+
Sbjct: 969 IGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFI--- 1025
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
Q A ++ +E++ DL++ KD + + + IG + N K
Sbjct: 1026 ------QKAFVRKQKALDEIKPLEDLNNK---KDSCISNHTTIEIGKDL-------NYLK 1069
Query: 1065 KGKILMNNINAITDNHRDNRLDCE--LNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKG 1122
G + I + + + + D +N+ + + + + + F ES
Sbjct: 1070 DGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES--- 1126
Query: 1123 SADTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGADEDVVDDTPADCCP 1182
D + +EK +A+ G+ +V +E + P C
Sbjct: 1127 --DMEESKEKLNATSSSEGSTVDIGAPAE--------GEQP-EVEPEESL---EPEACFT 1172
Query: 1183 EQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHL 1242
E C +KF + + W LR +K++E+ +FET ++ MILLSS ALA ED+++
Sbjct: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI 1232
Query: 1243 PHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA 1302
R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV VSL++ A
Sbjct: 1233 EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTAN 1292
Query: 1303 LCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFA 1362
G + A K++RTLRALRPLRA+SR +GMR VVNAL+ AIPSI NVLLVCLIFWLIF+
Sbjct: 1293 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRAVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query: 1363 IMGVQLFAGKYFKCVDMNHTT---LSHEIIPDKNACTL---ENYT--WENSPMNFDHVGK 1414
IMGV LFAGK++ C+ N+TT ++ + + C N T W+N +NFD+VG
Sbjct: 1353 IMGVNLFAGKFYHCI--NYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL 1410
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
YL L QVATFKGW+ IM A+DSR V QP E N+YMYLY TLNLFIG
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 1475 VIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVT 1534
VIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +VF+ VT
Sbjct: 1471 VIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT 1529
Query: 1535 DKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHY 1594
+ FD+ IM+ I LNM+TM ++ QS+ + +L ++N++FIV+F+ EC+LK+ +LRY+Y
Sbjct: 1530 KQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYY 1589
Query: 1595 FVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTL 1654
F WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGAKGIRTL
Sbjct: 1590 FTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1649
Query: 1655 LFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQ 1714
LFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF SMI LFQ
Sbjct: 1650 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQ 1709
Query: 1715 MSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVIN 1770
++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++ISFL+V+N
Sbjct: 1710 ITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVLN 1769
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
MYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF D L+PPL
Sbjct: 1770 MYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPL 1829
Query: 1831 QIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRPE 1886
I KPNK ++I+MD+P+ GD + C+DIL A TK G I+ P
Sbjct: 1830 LIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPS 1889
Query: 1887 EAGYEPVSSTLWRQREEYCARLIQ 1910
+ YEP+++TL R++EE A +IQ
Sbjct: 1890 KVSYEPITTTLKRKQEEVSAIIIQ 1913
Score = 438 bits (1079), Expect = e-121
Identities = 231/426 (54%), Positives = 296/426 (69%), Gaps = 45/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL K+ + E+K + E GP+P++ LE G LP
Sbjct: 14 FRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDE---------NGPKPNSDLEAGKSLPF 64
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK I RFSAT AL+IL PFNPIR++AI
Sbjct: 65 -IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LF++ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW-------------GN 301
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P++ S+ GN
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 302 LTD-------ENWERFCQNETNWYG-EG-GDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
T NW+ + ++++++Y EG D LCGNSS AGQC GY+C++ G NPNY
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNY 362
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA
Sbjct: 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 423 VVAMAY 428
Score = 104 bits (250), Expect = 3e-21
Identities = 86/287 (29%), Positives = 150/287 (52%), Gaps = 37/287 (12%)
Query: 1520 RPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
+P + + +V +V D D+ I + I LN L M ++HY +E FS+VL N++F IF
Sbjct: 743 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K
Sbjct: 855 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D + T
Sbjct: 915 SNDCELPRWHMHDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQT 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+ +T + +VI L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1000
Score = 79.4 bits (187), Expect = 1e-13
Identities = 38/99 (38%), Positives = 58/99 (58%), Gaps = 3/99 (3%)
Query: 733 SRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLV 792
SR ++++ T E+ E+ ++K C K + +WDCC WL+ + V L+V
Sbjct: 700 SRQRAMSIASILTNTMEELEES---RQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVV 756
Query: 793 FDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 757 MDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN 795
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/187 (25%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ +W P+ ++ + +++ P L I I++N + M M P E
Sbjct: 730 YKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 789
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + +G+ ++
Sbjct: 790 VLSVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG 845
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 904
Query: 284 VLTQKCV 290
++CV
Sbjct: 905 KSYKECV 911
Score = 77.8 bits (183), Expect = 4e-13
Identities = 68/290 (23%), Positives = 137/290 (47%), Gaps = 30/290 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1313 PLRALSRFEGMRAVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINYTT 1371
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
+ ++ + E E+N + + ++ G GY+ L +
Sbjct: 1372 GEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGL-----GYLSLLQVATFKGW-- 1424
Query: 355 TSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y +NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1425 --MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Score = 76.2 bits (179), Expect = 1e-12
Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM +K +A
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIA 812
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IV +SL+ G ++ +R+ R LR + +
Sbjct: 813 MDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVEGLSVLRSFRLLRVFKLAKSWPTL 867
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 911
Score = 72.9 bits (171), Expect = 1e-11
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 11/135 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF ++ + +V G + A +T
Sbjct: 162 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSALRT 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 1374 FKCVDMNHTTLSHEI 1388
KC+ S EI
Sbjct: 276 NKCLQWPPDNSSFEI 290
Score = 56.0 bits (129), Expect = 1e-06
Identities = 44/166 (26%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+ +I+ F+M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 121 LAIKILVHSLFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 174
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 175 LARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 225
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 271
Score = 41.1 bits (92), Expect = 0.039
Identities = 36/169 (21%), Positives = 78/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTP-TVESTEV------IFTGIYT 178
P N + + + +F + I+ I +N + M++ T + E T + +F ++T
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ + Y WN DFVV+ L+ V M + +R
Sbjct: 1576 GECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
Score = 39.5 bits (88), Expect = 0.12
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1577 ECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1636
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1637 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1691
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1692 D-DMFNFETFGNSMICLFQI 1710
>M77235-1|AAA58644.1| 2016|Homo sapiens sodium channel alpha subunit
protein.
Length = 2016
Score = 979 bits (2424), Expect = 0.0
Identities = 516/1107 (46%), Positives = 691/1107 (62%), Gaps = 27/1107 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF-LKLL 1004
P D++ N + A RI R + ++KR DF LL
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL 985
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
+++ A+ A ++ + + K + + + G+ PGD +
Sbjct: 986 RHRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETQFEEGEQPGQGTPGDPEPV 1045
Query: 1065 KGKILMNNINAITDNHRDNRLDCELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKGSA 1124
I + + D D Q+ +S G R++ S S+
Sbjct: 1046 CVPIAVAESDT-DDQEEDEENSLGTEEESSKQQESQPVSGWPRGPPDSRTWSQVSATASS 1104
Query: 1125 DTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGAD--EDVVD-----DTP 1177
+ + D D+ A+ E + D P
Sbjct: 1105 EAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDP 1164
Query: 1178 ADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALAL 1237
DC E C ++ P A D + W LR + ++E+++FET +I MILLSS ALA
Sbjct: 1165 EDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAF 1224
Query: 1238 EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLI 1297
ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF+IV VSL+
Sbjct: 1225 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLV 1284
Query: 1298 NFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIF 1357
+ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLVCLIF
Sbjct: 1285 SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1344
Query: 1358 WLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WENSPMNFDH 1411
WLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W +NFD+
Sbjct: 1345 WLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDN 1404
Query: 1412 VGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNL 1471
VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y TLNL
Sbjct: 1405 VGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNL 1464
Query: 1472 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFE 1531
FIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +F+
Sbjct: 1465 FIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1523
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC++K+ ALR
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 1592 YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LRL++GAKGI
Sbjct: 1584 HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGI 1643
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMIL 1711
RTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+TF SM+
Sbjct: 1644 RTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLC 1703
Query: 1712 LFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +Y++ISFLI
Sbjct: 1704 LFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTTYIIISFLI 1762
Query: 1768 VINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLE 1827
V+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y LSDF D L
Sbjct: 1763 VVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALS 1822
Query: 1828 PPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVG 1883
PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1823 EPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAA 1882
Query: 1884 RPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1883 NPSKISYEPITTTLRRKHEEVSAMVIQ 1909
Score = 405 bits (996), Expect = e-111
Identities = 214/414 (51%), Positives = 275/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+P+RR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++AR F L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARAFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1368
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1369 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1426
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1427 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 76.6 bits (180), Expect = 8e-13
Identities = 45/137 (32%), Positives = 79/137 (57%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA F + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARAFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.6 bits (123), Expect = 7e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 AFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1573 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1676
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1599 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1658
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1659 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1707
>AB158469-1|BAD12084.1| 2016|Homo sapiens TTX-resistant sodium channel
protein.
Length = 2016
Score = 974 bits (2410), Expect = 0.0
Identities = 514/1107 (46%), Positives = 688/1107 (62%), Gaps = 27/1107 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF-LKLL 1004
P D++ N + A RI R + ++KR DF LL
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL 985
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
+++ A+ A ++ + + K + + G+ PGD +
Sbjct: 986 RHRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPV 1045
Query: 1065 KGKILMNNINAITDNHRDNRLDCELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKGSA 1124
I + + D D Q+ +S G R++ S S+
Sbjct: 1046 CVPIAVAESDT-DDQEEDEENSLGTEEESSKQQESQPVSGWPRGPPDSRTWSQVSATASS 1104
Query: 1125 DTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGAD--EDVVD-----DTP 1177
+ + D D+ A+ E + D P
Sbjct: 1105 EAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDP 1164
Query: 1178 ADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALAL 1237
DC E C ++ P A D + W LR + ++E+++FET +I MILLSS ALA
Sbjct: 1165 EDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAF 1224
Query: 1238 EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLI 1297
ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF+IV VSL+
Sbjct: 1225 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLV 1284
Query: 1298 NFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIF 1357
+ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLVCLIF
Sbjct: 1285 SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1344
Query: 1358 WLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WENSPMNFDH 1411
WLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W +NFD+
Sbjct: 1345 WLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDN 1404
Query: 1412 VGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNL 1471
VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y TLNL
Sbjct: 1405 VGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNL 1464
Query: 1472 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFE 1531
FIGVIIDNFN+QKK GG ++FMTE+QKKYYNA KK+GSKKP K IPRP + Q +F+
Sbjct: 1465 FIGVIIDNFNQQKKTLGGQ-DIFMTEEQKKYYNATKKLGSKKPQKPIPRPLNKYQGFIFD 1523
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC++K+ ALR
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 1592 YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LRL++GAKGI
Sbjct: 1584 HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGI 1643
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMIL 1711
RTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+TF SM+
Sbjct: 1644 RTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLC 1703
Query: 1712 LFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +Y++ISFLI
Sbjct: 1704 LFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTTYIIISFLI 1762
Query: 1768 VINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLE 1827
V+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y LSDF D L
Sbjct: 1763 VVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALS 1822
Query: 1828 PPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVG 1883
PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1823 EPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAA 1882
Query: 1884 RPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1883 NPSKISYEPITTTLRRKHEEVSAMVIQ 1909
Score = 408 bits (1004), Expect = e-112
Identities = 217/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LR WNWLDF VI +AYV+ I LGNL+ALRTFRVLRALKT++++PGLKTIVGA+
Sbjct: 184 HAFTFLRGPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1368
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1369 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1426
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1427 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
Score = 81.8 bits (193), Expect = 2e-14
Identities = 41/106 (38%), Positives = 63/106 (59%), Gaps = 5/106 (4%)
Query: 726 IEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQ 785
+E+ G + RA VSV E +E + K C + + +W+CC LW+ +
Sbjct: 653 VEEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIK 707
Query: 786 KYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 708 QGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 77.4 bits (182), Expect = 5e-13
Identities = 47/137 (34%), Positives = 81/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT W WLDF +++++ +V+ G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRGPWNWLDFSVIIMA---YVSENIKLGNL 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 50.8 bits (116), Expect = 5e-05
Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F PWN DF V++ + +S E + L +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRGPWNWLDFSVIIMAYVS-------ENIKLGN--LSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1573 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1676
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1599 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1658
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1659 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1707
>M81758-1|AAA60554.1| 1836|Homo sapiens sodium channel alpha subunit
protein.
Length = 1836
Score = 842 bits (2084), Expect = 0.0
Identities = 411/757 (54%), Positives = 556/757 (73%), Gaps = 16/757 (2%)
Query: 1168 ADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITM 1227
A+E+ + P +C E C Q++P L D + W TLR FK++E+ +FET ++ M
Sbjct: 981 AEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFM 1040
Query: 1228 ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWL 1287
ILLSS ALA ED+++ R +++ IL Y D++FT IF +EML+KW+A GF+ YFTNAWCWL
Sbjct: 1041 ILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWL 1100
Query: 1288 DFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
DF+IV VS+I+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI
Sbjct: 1101 DFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSI 1160
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI--IPDKNACTLENYT---- 1401
NVLLVCLIFWLIF+IMGV LFAGK++ C++ T+ +I + +K+ C +T
Sbjct: 1161 MNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT-TSERFDISEVNNKSECESLMHTGQVR 1219
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W N +N+D+VG YL L QVATFKGW+ IM A+DSRE QP E N+YMYLY
Sbjct: 1220 WLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFI 1279
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP 1521
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1280 IFGSFFTLNLFIGVIIDNFNQQKKKLGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1338
Query: 1522 RWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
+ + Q +V+++VT + FD+ IM+ I LNM+TM ++ QS+ +L +NMIFI+IF+
Sbjct: 1339 QNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTG 1398
Query: 1582 ECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRV 1641
EC+LK+ ALR +YF WN+FDFVVV+ SI+ L LSD+I+KYFVSPTL RV+R+A++GRV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 1642 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN 1701
LRL++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGMS F +VK + G+DD++N
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFN 1518
Query: 1702 FKTFVQSMILLFQMSTSAGWDGVLDGIINE--EECD--LPDNERGSPGNCGSATIGITYL 1757
F+TF S+I LF+++TSAGWDG+L+ I+N +CD L + G+CG+ +IGI +
Sbjct: 1519 FETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFF 1578
Query: 1758 LSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYD 1817
SY++ISFLIV+NMYIA+ILEN++ ATE+ E L +DD++M+YE W++FDPD +Q+I Y
Sbjct: 1579 CSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYS 1638
Query: 1818 QLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKG--NPIE 1875
+LSDF+D L+ PL+I KPNK K+I++D+P+ GD + C+DIL ALTK+ G + ++
Sbjct: 1639 RLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1698
Query: 1876 ETGD--LEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+T + P + YEP+++TL R+ EE CA IQ
Sbjct: 1699 QTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQ 1735
Score = 300 bits (736), Expect = 4e-80
Identities = 156/304 (51%), Positives = 209/304 (68%), Gaps = 14/304 (4%)
Query: 17 RPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPVR 76
RPFTRESL + + ++ E R +P + LE G LP+
Sbjct: 18 RPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPER----------KPRSDLEAGKNLPM- 66
Query: 77 MQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIY 136
+ G P E+ PLED+DP+Y N+ TF+V++KGK IFRFSAT AL++L PF+ +RR AI
Sbjct: 67 IYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIK 126
Query: 137 ILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPF 195
+L+H LFS+FI+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF + F
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDF 186
Query: 196 TYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIES 255
T+LRD WNWLDF VI +AY+T +DLGN++ALRTFRVLRALKT+ ++PGLKTIVGA+I+S
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQS 246
Query: 256 VKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNET 315
VK L DV+ILT+F LSVFAL+GLQ++MG L QKCV+ +P + N T + + + N+T
Sbjct: 247 VKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVR-WPPPFNDTNTTWYSNDTWYGNDT 305
Query: 316 NWYG 319
WYG
Sbjct: 306 -WYG 308
Score = 169 bits (411), Expect = 9e-41
Identities = 89/184 (48%), Positives = 111/184 (60%), Gaps = 5/184 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 668 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 727
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFR+LCGEWIE+MWDCM + G C+ FL +V
Sbjct: 728 ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMV 787
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A RI I + K A L LL
Sbjct: 788 IGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAK---AFLLGLL 844
Query: 1005 KNKL 1008
K+
Sbjct: 845 HGKI 848
Score = 143 bits (347), Expect = 5e-33
Identities = 73/123 (59%), Positives = 86/123 (69%), Gaps = 14/123 (11%)
Query: 298 SWGNLTDENWERFCQNETNWYG-EGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYT 355
SW +W+ + +E N+Y EG D LCGNSS AG C GY C++ G NPNYGYT
Sbjct: 329 SWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPKGYECIKT-GRNPNYGYT 387
Query: 356 SFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVA 404
S+DTF WAFL+ FRLMTQDYWENL+QL FFVVIIFLGSFYL+NLILA+VA
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
Query: 405 MSY 407
M+Y
Sbjct: 448 MAY 450
Score = 98.7 bits (235), Expect = 2e-19
Identities = 79/262 (30%), Positives = 135/262 (51%), Gaps = 33/262 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I+ IV D D+ I + I LN L M ++HY +E F VL N++F IF++E +LK+
Sbjct: 570 IIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKL 629
Query: 1588 FAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVK 1646
A+ Y YF + WN+FD ++V S++ L L+++ L V+R ++ RV +L K
Sbjct: 630 IAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLLRVFKLAK 681
Query: 1647 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KGGLD---DV 1699
+ L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K LD
Sbjct: 682 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
Query: 1700 YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLS 1759
++ F S +++F++ W I +C E C +T L
Sbjct: 742 WHMHDFFHSFLIVFRI-LCGEW------IETMWDC----MEVAGQAMC------LTVFLM 784
Query: 1760 YLVISFLIVINMYIAVILENYS 1781
+VI L+V+N+++A++L ++S
Sbjct: 785 VMVIGNLVVLNLFLALLLSSFS 806
Score = 81.4 bits (192), Expect = 3e-14
Identities = 45/164 (27%), Positives = 85/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + + I+L++L +A+E H P ++L + +FT IF EM++K +A
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAME--HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ +YF W D IIV +SL+ G +Q +R+ R LR + +
Sbjct: 632 MDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQGLSVLRSFRLLRVFKLAKSWPTL 686
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 687 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 730
Score = 79.8 bits (188), Expect = 9e-14
Identities = 47/173 (27%), Positives = 92/173 (53%), Gaps = 13/173 (7%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P+ + + I++ P L I I++N + M M P E + ++FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGNLAALRTFRVLRALK 237
E +K++A + P+ Y + WN D +++ L+ V +G+ ++ L+ LR+FR+LR K
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV 290
P L ++ + SV L ++ ++ + +FA++G+Q++ G ++CV
Sbjct: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 79.0 bits (186), Expect = 2e-13
Identities = 77/300 (25%), Positives = 142/300 (47%), Gaps = 51/300 (17%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTT---------PTVESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + +E + +FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ +++ +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
N T ERF +E N E C + GQ ++ ++ N GY
Sbjct: 1191 ------NTTTS--ERFDISEVNNKSE------CESLMHTGQVR--WLNVKVNYDNVGLGY 1234
Query: 355 TSF---DTF-GW-----AFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
S TF GW A + + Q +E NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1235 LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
Score = 78.6 bits (185), Expect = 2e-13
Identities = 31/58 (53%), Positives = 43/58 (74%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+WDCC WL+F+ + L+V DPFV+L IT+CIV+NTLFMA++H+ M + D L GN
Sbjct: 557 IWDCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN 614
Score = 74.1 bits (174), Expect = 5e-12
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 19/179 (10%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
+ +R K++ + F ++ IL + + + + D P +++ Y FT I+
Sbjct: 117 FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPP----PWSKNVEY----TFTGIY 168
Query: 1264 FIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLR 1319
E LIK LA GF + + W WLDF ++M++ ++ G I A +T R LR
Sbjct: 169 TFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMA---YLTEFVDLGNISALRTFRVLR 225
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKCV 1377
AL+ + + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KCV
Sbjct: 226 ALKTITVIP---GLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 20/156 (12%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY----- 1592
F M IM+ I N + MT+ +S ++Y F I++ E L+KI A +
Sbjct: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
Query: 1593 HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIR 1652
+ +PWN DF V+M + L+ FV + +R +V R L+ + G++
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLT---------EFVDLGNISALRTFRVLRALKTITVIPGLK 237
Query: 1653 TLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE-------STEVIFTGIYT 178
P N I+ + ++ F + I+ I +N + M++ T + + +IF I+T
Sbjct: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFT 1397
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K++A L+ + Y WN DFVV+ L+ V + + DL +R
Sbjct: 1398 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1452
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1453 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1501
Score = 37.5 bits (83), Expect = 0.48
Identities = 29/140 (20%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C L ++Y + ++ F + + L IV L + + + + + ++ RV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L + + L+ + ++ AL N+ +L +++FI+++ GM F YV + G
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA-----YVKK-ESG 1512
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
+NF F +S + +F +
Sbjct: 1513 IDDMFNFETFGNSIICLFEI 1532
>AY212253-1|AAO83647.1| 1836|Homo sapiens skeletal muscle
voltage-dependent sodium channel type IV alpha subunit
protein.
Length = 1836
Score = 842 bits (2084), Expect = 0.0
Identities = 411/757 (54%), Positives = 556/757 (73%), Gaps = 16/757 (2%)
Query: 1168 ADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITM 1227
A+E+ + P +C E C Q++P L D + W TLR FK++E+ +FET ++ M
Sbjct: 981 AEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFM 1040
Query: 1228 ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWL 1287
ILLSS ALA ED+++ R +++ IL Y D++FT IF +EML+KW+A GF+ YFTNAWCWL
Sbjct: 1041 ILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWL 1100
Query: 1288 DFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
DF+IV VS+I+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI
Sbjct: 1101 DFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSI 1160
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI--IPDKNACTLENYT---- 1401
NVLLVCLIFWLIF+IMGV LFAGK++ C++ T+ +I + +K+ C +T
Sbjct: 1161 MNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT-TSERFDISEVNNKSECESLMHTGQVR 1219
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W N +N+D+VG YL L QVATFKGW+ IM A+DSRE QP E N+YMYLY
Sbjct: 1220 WLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFI 1279
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP 1521
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1280 IFGSFFTLNLFIGVIIDNFNQQKKKLGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1338
Query: 1522 RWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
+ + Q +V+++VT + FD+ IM+ I LNM+TM ++ QS+ +L +NMIFI+IF+
Sbjct: 1339 QNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTG 1398
Query: 1582 ECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRV 1641
EC+LK+ ALR +YF WN+FDFVVV+ SI+ L LSD+I+KYFVSPTL RV+R+A++GRV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 1642 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN 1701
LRL++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGMS F +VK + G+DD++N
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFN 1518
Query: 1702 FKTFVQSMILLFQMSTSAGWDGVLDGIINE--EECD--LPDNERGSPGNCGSATIGITYL 1757
F+TF S+I LF+++TSAGWDG+L+ I+N +CD L + G+CG+ +IGI +
Sbjct: 1519 FETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFF 1578
Query: 1758 LSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYD 1817
SY++ISFLIV+NMYIA+ILEN++ ATE+ E L +DD++M+YE W++FDPD +Q+I Y
Sbjct: 1579 CSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYS 1638
Query: 1818 QLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKG--NPIE 1875
+LSDF+D L+ PL+I KPNK K+I++D+P+ GD + C+DIL ALTK+ G + ++
Sbjct: 1639 RLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1698
Query: 1876 ETGD--LEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+T + P + YEP+++TL R+ EE CA IQ
Sbjct: 1699 QTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQ 1735
Score = 300 bits (736), Expect = 4e-80
Identities = 156/304 (51%), Positives = 209/304 (68%), Gaps = 14/304 (4%)
Query: 17 RPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPVR 76
RPFTRESL + + ++ E R +P + LE G LP+
Sbjct: 18 RPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPER----------KPRSDLEAGKNLPM- 66
Query: 77 MQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIY 136
+ G P E+ PLED+DP+Y N+ TF+V++KGK IFRFSAT AL++L PF+ +RR AI
Sbjct: 67 IYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIK 126
Query: 137 ILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPF 195
+L+H LFS+FI+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF + F
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDF 186
Query: 196 TYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIES 255
T+LRD WNWLDF VI +AY+T +DLGN++ALRTFRVLRALKT+ ++PGLKTIVGA+I+S
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQS 246
Query: 256 VKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNET 315
VK L DV+ILT+F LSVFAL+GLQ++MG L QKCV+ +P + N T + + + N+T
Sbjct: 247 VKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVR-WPPPFNDTNTTWYSNDTWYGNDT 305
Query: 316 NWYG 319
WYG
Sbjct: 306 -WYG 308
Score = 169 bits (411), Expect = 9e-41
Identities = 89/184 (48%), Positives = 111/184 (60%), Gaps = 5/184 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 668 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 727
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFR+LCGEWIE+MWDCM + G C+ FL +V
Sbjct: 728 ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMV 787
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A RI I + K A L LL
Sbjct: 788 IGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAK---AFLLGLL 844
Query: 1005 KNKL 1008
K+
Sbjct: 845 HGKI 848
Score = 143 bits (347), Expect = 5e-33
Identities = 73/123 (59%), Positives = 86/123 (69%), Gaps = 14/123 (11%)
Query: 298 SWGNLTDENWERFCQNETNWYG-EGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYT 355
SW +W+ + +E N+Y EG D LCGNSS AG C GY C++ G NPNYGYT
Sbjct: 329 SWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKT-GRNPNYGYT 387
Query: 356 SFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVA 404
S+DTF WAFL+ FRLMTQDYWENL+QL FFVVIIFLGSFYL+NLILA+VA
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
Query: 405 MSY 407
M+Y
Sbjct: 448 MAY 450
Score = 98.7 bits (235), Expect = 2e-19
Identities = 79/262 (30%), Positives = 135/262 (51%), Gaps = 33/262 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I+ IV D D+ I + I LN L M ++HY +E F VL N++F IF++E +LK+
Sbjct: 570 IIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKL 629
Query: 1588 FAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVK 1646
A+ Y YF + WN+FD ++V S++ L L+++ L V+R ++ RV +L K
Sbjct: 630 IAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLLRVFKLAK 681
Query: 1647 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KGGLD---DV 1699
+ L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K LD
Sbjct: 682 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
Query: 1700 YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLS 1759
++ F S +++F++ W I +C E C +T L
Sbjct: 742 WHMHDFFHSFLIVFRI-LCGEW------IETMWDC----MEVAGQAMC------LTVFLM 784
Query: 1760 YLVISFLIVINMYIAVILENYS 1781
+VI L+V+N+++A++L ++S
Sbjct: 785 VMVIGNLVVLNLFLALLLSSFS 806
Score = 81.4 bits (192), Expect = 3e-14
Identities = 45/164 (27%), Positives = 85/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + + I+L++L +A+E H P ++L + +FT IF EM++K +A
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAME--HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ +YF W D IIV +SL+ G +Q +R+ R LR + +
Sbjct: 632 MDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQGLSVLRSFRLLRVFKLAKSWPTL 686
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 687 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 730
Score = 79.8 bits (188), Expect = 9e-14
Identities = 47/173 (27%), Positives = 92/173 (53%), Gaps = 13/173 (7%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P+ + + I++ P L I I++N + M M P E + ++FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGNLAALRTFRVLRALK 237
E +K++A + P+ Y + WN D +++ L+ V +G+ ++ L+ LR+FR+LR K
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV 290
P L ++ + SV L ++ ++ + +FA++G+Q++ G ++CV
Sbjct: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 79.0 bits (186), Expect = 2e-13
Identities = 77/300 (25%), Positives = 142/300 (47%), Gaps = 51/300 (17%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTT---------PTVESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + +E + +FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ +++ +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
N T ERF +E N E C + GQ ++ ++ N GY
Sbjct: 1191 ------NTTTS--ERFDISEVNNKSE------CESLMHTGQVR--WLNVKVNYDNVGLGY 1234
Query: 355 TSF---DTF-GW-----AFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
S TF GW A + + Q +E NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1235 LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
Score = 76.6 bits (180), Expect = 8e-13
Identities = 30/58 (51%), Positives = 43/58 (74%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+W+CC WL+F+ + L+V DPFV+L IT+CIV+NTLFMA++H+ M + D L GN
Sbjct: 557 IWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN 614
Score = 74.1 bits (174), Expect = 5e-12
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 19/179 (10%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
+ +R K++ + F ++ IL + + + + D P +++ Y FT I+
Sbjct: 117 FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPP----PWSKNVEY----TFTGIY 168
Query: 1264 FIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLR 1319
E LIK LA GF + + W WLDF ++M++ ++ G I A +T R LR
Sbjct: 169 TFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMA---YLTEFVDLGNISALRTFRVLR 225
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKCV 1377
AL+ + + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KCV
Sbjct: 226 ALKTITVIP---GLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 20/156 (12%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY----- 1592
F M IM+ I N + MT+ +S ++Y F I++ E L+KI A +
Sbjct: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
Query: 1593 HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIR 1652
+ +PWN DF V+M + L+ FV + +R +V R L+ + G++
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLT---------EFVDLGNISALRTFRVLRALKTITVIPGLK 237
Query: 1653 TLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N I+ + ++ F + I+ I +N + M++ T + + +IF I+T
Sbjct: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFT 1397
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K++A L+ + Y WN DFVV+ L+ V + + DL +R
Sbjct: 1398 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1452
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1453 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1501
Score = 37.5 bits (83), Expect = 0.48
Identities = 29/140 (20%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C L ++Y + ++ F + + L IV L + + + + + ++ RV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L + + L+ + ++ AL N+ +L +++FI+++ GM F YV + G
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA-----YVKK-ESG 1512
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
+NF F +S + +F +
Sbjct: 1513 IDDMFNFETFGNSIICLFEI 1532
>L01983-1|AAA75557.1| 1835|Homo sapiens sodium channel alpha subunit
protein.
Length = 1835
Score = 839 bits (2075), Expect = 0.0
Identities = 410/757 (54%), Positives = 555/757 (73%), Gaps = 17/757 (2%)
Query: 1168 ADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITM 1227
A+E+ + P +C E C Q++P L D + W TLR FK++E+ +FET ++ M
Sbjct: 981 AEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFM 1040
Query: 1228 ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWL 1287
ILLSS ALA ED+++ R +++ IL Y D++FT IF +EML+KW+A GF+ YFTNAWCWL
Sbjct: 1041 ILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWL 1100
Query: 1288 DFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
DF+IV VS+I+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI
Sbjct: 1101 DFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSI 1160
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI--IPDKNACTLENYT---- 1401
NVLLVCLIFWLIF+IMGV LFAGK++ C++ T+ +I + +K+ C +T
Sbjct: 1161 MNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT-TSERFDISEVNNKSECESLMHTGQVR 1219
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W N +N+D+VG YL L QVATFKGW+ IM A+DSRE QP E N+YMYLY
Sbjct: 1220 WLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFI 1279
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP 1521
TLNLFIGVIIDNFN+QKKK G ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1280 IFGSFFTLNLFIGVIIDNFNQQKKKGGK--DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1337
Query: 1522 RWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
+ + Q +V+++VT + FD+ IM+ I LNM+TM ++ QS+ +L +NMIFI+IF+
Sbjct: 1338 QNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTG 1397
Query: 1582 ECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRV 1641
EC+LK+ ALR +YF WN+FDFVVV+ SI+ L LSD+I+KYFVSPTL RV+R+A++GRV
Sbjct: 1398 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1457
Query: 1642 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN 1701
LRL++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGMS F +VK + G+DD++N
Sbjct: 1458 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFN 1517
Query: 1702 FKTFVQSMILLFQMSTSAGWDGVLDGIINE--EECD--LPDNERGSPGNCGSATIGITYL 1757
F+TF S+I LF+++TSAGWDG+L+ I+N +CD L + G+CG+ +IGI +
Sbjct: 1518 FETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFF 1577
Query: 1758 LSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYD 1817
SY++ISFLIV+NMYIA+ILEN++ ATE+ E L +DD++M+YE W++FDPD +Q+I Y
Sbjct: 1578 CSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYS 1637
Query: 1818 QLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKG--NPIE 1875
+LSDF+D L+ PL+I KPNK K+I++D+P+ GD + C+DIL ALTK+ G + ++
Sbjct: 1638 RLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1697
Query: 1876 ETGD--LEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+T + P + YEP+++TL R+ EE CA IQ
Sbjct: 1698 QTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQ 1734
Score = 300 bits (736), Expect = 4e-80
Identities = 156/304 (51%), Positives = 209/304 (68%), Gaps = 14/304 (4%)
Query: 17 RPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPVR 76
RPFTRESL + + ++ E R +P + LE G LP+
Sbjct: 18 RPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPER----------KPRSDLEAGKNLPM- 66
Query: 77 MQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIY 136
+ G P E+ PLED+DP+Y N+ TF+V++KGK IFRFSAT AL++L PF+ +RR AI
Sbjct: 67 IYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIK 126
Query: 137 ILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPF 195
+L+H LFS+FI+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF + F
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDF 186
Query: 196 TYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIES 255
T+LRD WNWLDF VI +AY+T +DLGN++ALRTFRVLRALKT+ ++PGLKTIVGA+I+S
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQS 246
Query: 256 VKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNET 315
VK L DV+ILT+F LSVFAL+GLQ++MG L QKCV+ +P + N T + + + N+T
Sbjct: 247 VKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVR-WPPPFNDTNTTWYSNDTWYGNDT 305
Query: 316 NWYG 319
WYG
Sbjct: 306 -WYG 308
Score = 169 bits (411), Expect = 9e-41
Identities = 89/184 (48%), Positives = 111/184 (60%), Gaps = 5/184 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 668 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 727
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFR+LCGEWIE+MWDCM + G C+ FL +V
Sbjct: 728 ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMV 787
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A RI I + K A L LL
Sbjct: 788 IGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAK---AFLLGLL 844
Query: 1005 KNKL 1008
K+
Sbjct: 845 HGKI 848
Score = 143 bits (347), Expect = 5e-33
Identities = 73/123 (59%), Positives = 86/123 (69%), Gaps = 14/123 (11%)
Query: 298 SWGNLTDENWERFCQNETNWYG-EGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYT 355
SW +W+ + +E N+Y EG D LCGNSS AG C GY C++ G NPNYGYT
Sbjct: 329 SWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKT-GRNPNYGYT 387
Query: 356 SFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVA 404
S+DTF WAFL+ FRLMTQDYWENL+QL FFVVIIFLGSFYL+NLILA+VA
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
Query: 405 MSY 407
M+Y
Sbjct: 448 MAY 450
Score = 98.7 bits (235), Expect = 2e-19
Identities = 79/262 (30%), Positives = 135/262 (51%), Gaps = 33/262 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I+ IV D D+ I + I LN L M ++HY +E F VL N++F IF++E +LK+
Sbjct: 570 IIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKL 629
Query: 1588 FAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVK 1646
A+ Y YF + WN+FD ++V S++ L L+++ L V+R ++ RV +L K
Sbjct: 630 IAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLLRVFKLAK 681
Query: 1647 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KGGLD---DV 1699
+ L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K LD
Sbjct: 682 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
Query: 1700 YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLS 1759
++ F S +++F++ W I +C E C +T L
Sbjct: 742 WHMHDFFHSFLIVFRI-LCGEW------IETMWDC----MEVAGQAMC------LTVFLM 784
Query: 1760 YLVISFLIVINMYIAVILENYS 1781
+VI L+V+N+++A++L ++S
Sbjct: 785 VMVIGNLVVLNLFLALLLSSFS 806
Score = 81.4 bits (192), Expect = 3e-14
Identities = 45/164 (27%), Positives = 85/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + + I+L++L +A+E H P ++L + +FT IF EM++K +A
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAME--HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ +YF W D IIV +SL+ G +Q +R+ R LR + +
Sbjct: 632 MDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQGLSVLRSFRLLRVFKLAKSWPTL 686
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 687 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 730
Score = 79.8 bits (188), Expect = 9e-14
Identities = 47/173 (27%), Positives = 92/173 (53%), Gaps = 13/173 (7%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P+ + + I++ P L I I++N + M M P E + ++FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGNLAALRTFRVLRALK 237
E +K++A + P+ Y + WN D +++ L+ V +G+ ++ L+ LR+FR+LR K
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV 290
P L ++ + SV L ++ ++ + +FA++G+Q++ G ++CV
Sbjct: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 79.0 bits (186), Expect = 2e-13
Identities = 77/300 (25%), Positives = 142/300 (47%), Gaps = 51/300 (17%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTT---------PTVESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + +E + +FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ +++ +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
N T ERF +E N E C + GQ ++ ++ N GY
Sbjct: 1191 ------NTTTS--ERFDISEVNNKSE------CESLMHTGQVR--WLNVKVNYDNVGLGY 1234
Query: 355 TSF---DTF-GW-----AFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
S TF GW A + + Q +E NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1235 LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
Score = 76.6 bits (180), Expect = 8e-13
Identities = 30/58 (51%), Positives = 43/58 (74%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+W+CC WL+F+ + L+V DPFV+L IT+CIV+NTLFMA++H+ M + D L GN
Sbjct: 557 IWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN 614
Score = 74.1 bits (174), Expect = 5e-12
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 19/179 (10%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
+ +R K++ + F ++ IL + + + + D P +++ Y FT I+
Sbjct: 117 FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPP----PWSKNVEY----TFTGIY 168
Query: 1264 FIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLR 1319
E LIK LA GF + + W WLDF ++M++ ++ G I A +T R LR
Sbjct: 169 TFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMA---YLTEFVDLGNISALRTFRVLR 225
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKCV 1377
AL+ + + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KCV
Sbjct: 226 ALKTITVIP---GLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 20/156 (12%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY----- 1592
F M IM+ I N + MT+ +S ++Y F I++ E L+KI A +
Sbjct: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
Query: 1593 HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIR 1652
+ +PWN DF V+M + L+ FV + +R +V R L+ + G++
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLT---------EFVDLGNISALRTFRVLRALKTITVIPGLK 237
Query: 1653 TLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N I+ + ++ F + I+ I +N + M++ T + + +IF I+T
Sbjct: 1337 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFT 1396
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K++A L+ + Y WN DFVV+ L+ V + + DL +R
Sbjct: 1397 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1451
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1452 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1500
Score = 37.5 bits (83), Expect = 0.48
Identities = 29/140 (20%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C L ++Y + ++ F + + L IV L + + + + + ++ RV
Sbjct: 1398 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1457
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L + + L+ + ++ AL N+ +L +++FI+++ GM F YV + G
Sbjct: 1458 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA-----YVKK-ESG 1511
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
+NF F +S + +F +
Sbjct: 1512 IDDMFNFETFGNSIICLFEI 1531
>L04236-1|AAB59624.1| 1836|Homo sapiens skeletal muscle sodium channel
alpha subunit protein.
Length = 1836
Score = 838 bits (2073), Expect = 0.0
Identities = 409/757 (54%), Positives = 554/757 (73%), Gaps = 16/757 (2%)
Query: 1168 ADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITM 1227
A+E+ + P +C E C Q++P L D + W TLR FK++E+ +FET ++ M
Sbjct: 981 AEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFM 1040
Query: 1228 ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWL 1287
ILLSS ALA ED+++ R +++ IL Y D++FT IF +EML+KW+A GF+ YFTNAWCWL
Sbjct: 1041 ILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWL 1100
Query: 1288 DFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
DF+IV VS+I+ VA G + K++RTLRALRPLRA+SR +GMRVVV L+ AIPSI
Sbjct: 1101 DFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVKPLLGAIPSI 1160
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI--IPDKNACTLENYT---- 1401
NVLLVCLIFWLIF+IMGV LFAGK++ C++ T+ +I + +K+ C +T
Sbjct: 1161 MNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT-TSERFDISEVNNKSECESLMHTGQVR 1219
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W N +N+D+VG YL L QVATFKGW+ IM A+DSRE QP E N+YMYLY
Sbjct: 1220 WLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFI 1279
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP 1521
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1280 IFGSFFTLNLFIGVIIDNFNQQKKKLGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1338
Query: 1522 RWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
+ + Q +V+++VT + FD+ IM+ I LNM+TM ++ QS+ +L +NMIFI+IF+
Sbjct: 1339 QNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTG 1398
Query: 1582 ECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRV 1641
EC+LK+ ALR +YF WN+FDFVVV+ SI+ L LSD+I+KYFVSPTL RV+R+A++GRV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 1642 LRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN 1701
LRL++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGMS F +VK + G+DD++N
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFN 1518
Query: 1702 FKTFVQSMILLFQMSTSAGWDGVLDGIINE--EECD--LPDNERGSPGNCGSATIGITYL 1757
F+TF S+I LF+++TSAGWDG+L+ I+N +CD L + G+CG+ +IGI +
Sbjct: 1519 FETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFF 1578
Query: 1758 LSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYD 1817
SY++ISFLIV+NMYIA+ILEN++ ATE+ E L +DD++M+YE W++FDPD +Q+I Y
Sbjct: 1579 CSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYS 1638
Query: 1818 QLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKG--NPIE 1875
+LSDF+D L+ PL+I KPNK K+I++D+P+ GD + C+DIL ALTK+ G + ++
Sbjct: 1639 RLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1698
Query: 1876 ETGD--LEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+T + P + YEP+++TL R+ EE CA IQ
Sbjct: 1699 QTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQ 1735
Score = 300 bits (736), Expect = 4e-80
Identities = 156/304 (51%), Positives = 209/304 (68%), Gaps = 14/304 (4%)
Query: 17 RPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPVR 76
RPFTRESL + + ++ E R +P + LE G LP+
Sbjct: 18 RPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPER----------KPRSDLEAGKNLPM- 66
Query: 77 MQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIY 136
+ G P E+ PLED+DP+Y N+ TF+V++KGK IFRFSAT AL++L PF+ +RR AI
Sbjct: 67 IYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIK 126
Query: 137 ILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPF 195
+L+H LFS+FI+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF + F
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDF 186
Query: 196 TYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIES 255
T+LRD WNWLDF VI +AY+T +DLGN++ALRTFRVLRALKT+ ++PGLKTIVGA+I+S
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQS 246
Query: 256 VKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNET 315
VK L DV+ILT+F LSVFAL+GLQ++MG L QKCV+ +P + N T + + + N+T
Sbjct: 247 VKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVR-WPPPFNDTNTTWYSNDTWYGNDT 305
Query: 316 NWYG 319
WYG
Sbjct: 306 -WYG 308
Score = 169 bits (411), Expect = 9e-41
Identities = 89/184 (48%), Positives = 111/184 (60%), Gaps = 5/184 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 668 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 727
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFR+LCGEWIE+MWDCM + G C+ FL +V
Sbjct: 728 ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMV 787
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A RI I + K A L LL
Sbjct: 788 IGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAK---AFLLGLL 844
Query: 1005 KNKL 1008
K+
Sbjct: 845 HGKI 848
Score = 143 bits (347), Expect = 5e-33
Identities = 73/123 (59%), Positives = 86/123 (69%), Gaps = 14/123 (11%)
Query: 298 SWGNLTDENWERFCQNETNWYG-EGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYT 355
SW +W+ + +E N+Y EG D LCGNSS AG C GY C++ G NPNYGYT
Sbjct: 329 SWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPQGYECIKT-GRNPNYGYT 387
Query: 356 SFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVA 404
S+DTF WAFL+ FRLMTQDYWENL+QL FFVVIIFLGSFYL+NLILA+VA
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
Query: 405 MSY 407
M+Y
Sbjct: 448 MAY 450
Score = 98.7 bits (235), Expect = 2e-19
Identities = 79/262 (30%), Positives = 135/262 (51%), Gaps = 33/262 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I+ IV D D+ I + I LN L M ++HY +E F VL N++F IF++E +LK+
Sbjct: 570 IIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKL 629
Query: 1588 FAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVK 1646
A+ Y YF + WN+FD ++V S++ L L+++ L V+R ++ RV +L K
Sbjct: 630 IAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLLRVFKLAK 681
Query: 1647 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KGGLD---DV 1699
+ L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K LD
Sbjct: 682 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
Query: 1700 YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLS 1759
++ F S +++F++ W I +C E C +T L
Sbjct: 742 WHMHDFFHSFLIVFRI-LCGEW------IETMWDC----MEVAGQAMC------LTVFLM 784
Query: 1760 YLVISFLIVINMYIAVILENYS 1781
+VI L+V+N+++A++L ++S
Sbjct: 785 VMVIGNLVVLNLFLALLLSSFS 806
Score = 81.4 bits (192), Expect = 3e-14
Identities = 45/164 (27%), Positives = 85/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + + I+L++L +A+E H P ++L + +FT IF EM++K +A
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAME--HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ +YF W D IIV +SL+ G +Q +R+ R LR + +
Sbjct: 632 MDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQGLSVLRSFRLLRVFKLAKSWPTL 686
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 687 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 730
Score = 79.8 bits (188), Expect = 9e-14
Identities = 47/173 (27%), Positives = 92/173 (53%), Gaps = 13/173 (7%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P+ + + I++ P L I I++N + M M P E + ++FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGNLAALRTFRVLRALK 237
E +K++A + P+ Y + WN D +++ L+ V +G+ ++ L+ LR+FR+LR K
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV 290
P L ++ + SV L ++ ++ + +FA++G+Q++ G ++CV
Sbjct: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 76.6 bits (180), Expect = 8e-13
Identities = 30/58 (51%), Positives = 43/58 (74%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+W+CC WL+F+ + L+V DPFV+L IT+CIV+NTLFMA++H+ M + D L GN
Sbjct: 557 IWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN 614
Score = 76.2 bits (179), Expect = 1e-12
Identities = 76/300 (25%), Positives = 141/300 (47%), Gaps = 51/300 (17%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTT---------PTVESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + +E + +FT I+ E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF + Y +AW WLDF+++ ++ +++ +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V ++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1136 PLRALSRFEGMRVVVKPLLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
N T ERF +E N E C + GQ ++ ++ N GY
Sbjct: 1191 ------NTTTS--ERFDISEVNNKSE------CESLMHTGQVR--WLNVKVNYDNVGLGY 1234
Query: 355 TSF---DTF-GW-----AFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
S TF GW A + + Q +E NLY L+FV+ I GSF+ +NL + ++
Sbjct: 1235 LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
Score = 74.1 bits (174), Expect = 5e-12
Identities = 50/179 (27%), Positives = 93/179 (51%), Gaps = 19/179 (10%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
+ +R K++ + F ++ IL + + + + D P +++ Y FT I+
Sbjct: 117 FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPP----PWSKNVEY----TFTGIY 168
Query: 1264 FIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLR 1319
E LIK LA GF + + W WLDF ++M++ ++ G I A +T R LR
Sbjct: 169 TFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMA---YLTEFVDLGNISALRTFRVLR 225
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKCV 1377
AL+ + + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KCV
Sbjct: 226 ALKTITVIP---GLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 20/156 (12%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY----- 1592
F M IM+ I N + MT+ +S ++Y F I++ E L+KI A +
Sbjct: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
Query: 1593 HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIR 1652
+ +PWN DF V+M + L+ FV + +R +V R L+ + G++
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLT---------EFVDLGNISALRTFRVLRALKTITVIPGLK 237
Query: 1653 TLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE-------STEVIFTGIYT 178
P N I+ + ++ F + I+ I +N + M++ T + + +IF I+T
Sbjct: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFT 1397
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K++A L+ + Y WN DFVV+ L+ V + + DL +R
Sbjct: 1398 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1452
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1453 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1501
Score = 37.5 bits (83), Expect = 0.48
Identities = 29/140 (20%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C L ++Y + ++ F + + L IV L + + + + + ++ RV
Sbjct: 1399 ECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRV 1458
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L + + L+ + ++ AL N+ +L +++FI+++ GM F YV + G
Sbjct: 1459 LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA-----YVKK-ESG 1512
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
+NF F +S + +F +
Sbjct: 1513 IDDMFNFETFGNSIICLFEI 1532
>AJ251507-1|CAB85895.1| 1951|Homo sapiens type III sodium channel
protein protein.
Length = 1951
Score = 835 bits (2065), Expect = 0.0
Identities = 409/750 (54%), Positives = 543/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1469
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1470 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1529
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1530 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGA 1589
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1590 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1649
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1650 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1709
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1710 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1769
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1770 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRF 1829
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1830 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1859
Score = 428 bits (1055), Expect = e-119
Identities = 226/426 (53%), Positives = 293/426 (68%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT + LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1007
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1319 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1369
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1370 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1418
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 56.8 bits (131), Expect = 7e-07
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FVS + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1522 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1625
Score = 37.9 bits (84), Expect = 0.36
Identities = 29/140 (20%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1545 FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1604
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1605 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1657
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1658 ---TSAGWDGLLAPILNSAP 1674
>AF330135-2|AAG53415.1| 1951|Homo sapiens voltage-gated sodium channel
type III alpha subunit protein.
Length = 1951
Score = 835 bits (2065), Expect = 0.0
Identities = 409/750 (54%), Positives = 543/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1469
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1470 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1529
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1530 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGA 1589
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1590 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1649
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1650 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1709
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1710 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1769
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1770 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRF 1829
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1830 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1859
Score = 431 bits (1061), Expect = e-119
Identities = 227/426 (53%), Positives = 294/426 (69%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1007
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1319 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1369
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1370 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1418
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 72.5 bits (170), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 55.2 bits (127), Expect = 2e-06
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FV + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1522 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1625
Score = 37.9 bits (84), Expect = 0.36
Identities = 29/140 (20%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1545 FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1604
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1605 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1657
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1658 ---TSAGWDGLLAPILNSAP 1674
>AF330135-1|AAG53414.1| 1951|Homo sapiens voltage-gated sodium channel
type III alpha subunit protein.
Length = 1951
Score = 835 bits (2065), Expect = 0.0
Identities = 409/750 (54%), Positives = 543/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1469
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1470 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1529
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1530 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGA 1589
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1590 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1649
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1650 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1709
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1710 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1769
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1770 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRF 1829
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1830 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1859
Score = 428 bits (1055), Expect = e-119
Identities = 226/426 (53%), Positives = 293/426 (68%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT + LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1007
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1319 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1369
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1370 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1418
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 56.8 bits (131), Expect = 7e-07
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FVS + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1522 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1625
Score = 37.9 bits (84), Expect = 0.36
Identities = 29/140 (20%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1545 FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1604
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1605 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1657
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1658 ---TSAGWDGLLAPILNSAP 1674
>AC013463-1|AAY15072.1| 2000|Homo sapiens unknown protein.
Length = 2000
Score = 835 bits (2065), Expect = 0.0
Identities = 409/750 (54%), Positives = 543/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1162 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1221
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1222 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1281
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1282 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1341
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1342 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1399
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1400 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1459
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1460 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1518
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1519 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1578
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1579 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGA 1638
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1639 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1698
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1699 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1758
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1759 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1818
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1819 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRF 1878
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1879 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1908
Score = 431 bits (1061), Expect = e-119
Identities = 227/426 (53%), Positives = 294/426 (69%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 830 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 887
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 888 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 947
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 948 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 1007
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 1008 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1056
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 816 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 867
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 926
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 927 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 969
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 970 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1001
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1367
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1368 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1418
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1419 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1467
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 731 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 790
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 791 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 846
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 847 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 905
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 906 KSYKECVCKINDD 918
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 694 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 748
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 749 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 796
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 813
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 814 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 868
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 869 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 912
Score = 72.5 bits (170), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 55.2 bits (127), Expect = 2e-06
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FV + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1570
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1571 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1625
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1626 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1674
Score = 37.9 bits (84), Expect = 0.36
Identities = 29/140 (20%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1594 FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1653
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1654 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1706
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1707 ---TSAGWDGLLAPILNSAP 1723
>EF179185-1|ABN05288.1| 2015|Homo sapiens sodium channel,
voltage-gated, type V, alpha (long QT syndrome 3)
protein.
Length = 2015
Score = 831 bits (2055), Expect = 0.0
Identities = 408/755 (54%), Positives = 538/755 (71%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1158 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1215
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1216 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1275
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1276 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1335
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1336 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1395
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1396 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1455
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1456 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1514
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1515 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1574
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1575 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1634
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1635 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1694
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1695 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1753
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1754 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1813
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1814 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1873
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1874 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1908
Score = 407 bits (1003), Expect = e-112
Identities = 216/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 980
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1367
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1368 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1426 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1468
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.2 bits (122), Expect = 9e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1571
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1572 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1626
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1627 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1675
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1598 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1657
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1658 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1706
>AY148488-1|AAN61120.1| 2015|Homo sapiens cardiac sodium channel alpha
subunit Nav1.5 protein.
Length = 2015
Score = 831 bits (2055), Expect = 0.0
Identities = 408/755 (54%), Positives = 538/755 (71%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1158 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1215
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1216 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1275
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1276 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1335
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1336 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1395
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1396 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1455
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1456 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1514
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1515 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1574
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1575 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1634
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1635 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1694
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1695 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1753
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1754 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1813
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1814 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1873
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1874 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1908
Score = 407 bits (1003), Expect = e-112
Identities = 216/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 980
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1367
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1368 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1426 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1468
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.2 bits (122), Expect = 9e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1571
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1572 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1626
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1627 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1675
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1598 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1657
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1658 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1706
>AY038064-1|AAK74065.1| 2015|Homo sapiens voltage-gated sodium channel
type V alpha subunit jejunal variant protein.
Length = 2015
Score = 831 bits (2055), Expect = 0.0
Identities = 408/755 (54%), Positives = 538/755 (71%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1158 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1215
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1216 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1275
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1276 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1335
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1336 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1395
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1396 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1455
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1456 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1514
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1515 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1574
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1575 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1634
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1635 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1694
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1695 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1753
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1754 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1813
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1814 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1873
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1874 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1908
Score = 407 bits (1003), Expect = e-112
Identities = 216/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 980
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1367
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1368 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1426 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1468
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.2 bits (122), Expect = 9e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1571
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1572 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1626
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1627 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1675
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1598 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1657
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1658 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1706
>AF482988-1|AAO91669.1| 2015|Homo sapiens cardiac sodium channel alpha
subunit protein.
Length = 2015
Score = 831 bits (2055), Expect = 0.0
Identities = 408/755 (54%), Positives = 538/755 (71%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1158 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1215
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1216 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1275
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1276 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1335
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1336 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1395
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1396 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1455
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1456 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1514
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1515 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1574
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1575 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1634
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1635 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1694
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1695 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1753
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1754 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1813
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1814 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1873
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1874 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1908
Score = 407 bits (1003), Expect = e-112
Identities = 216/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 980
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1367
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1368 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1426 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1468
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.2 bits (122), Expect = 9e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1571
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1572 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1626
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1627 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1675
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1598 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1657
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1658 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1706
>AF225988-1|AAF35390.1| 1980|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 1980
Score = 831 bits (2055), Expect = 0.0
Identities = 409/762 (53%), Positives = 546/762 (71%), Gaps = 17/762 (2%)
Query: 1163 DIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFET 1222
++ V E+ +D P C E C Q+F + + + W LR F ++E+ +FET
Sbjct: 1145 EVPVEQPEEYLD--PDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFET 1202
Query: 1223 AVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTN 1282
+I MILLSS ALA ED+++ R ++ IL Y D++FT IF +EML+KW A GF K+FTN
Sbjct: 1203 FIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTN 1262
Query: 1283 AWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQ 1342
AWCWLDF+IV VSL++ +A G + A K++RTLRALRPLRA+SR +GMRVVVNALV
Sbjct: 1263 AWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1322
Query: 1343 AIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV-DMNHTTLSHEIIPDKNACT--LE- 1398
AIPSI NVLLVCLIFWLIF+IMGV LFAGKY C + + E + +K C +E
Sbjct: 1323 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEG 1382
Query: 1399 NYT---WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYL 1455
N T W+N +NFD+VG YL L QVATFKGW+ IM A+DSR+ QP E NIYMY+
Sbjct: 1383 NNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYI 1442
Query: 1456 YXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL 1515
Y TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP
Sbjct: 1443 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQ 1501
Query: 1516 KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIF 1575
K IPRP + Q IVF+ VT + FD++IM+ I LNM+TM ++ QS+ +L ++N++F
Sbjct: 1502 KPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVF 1561
Query: 1576 IVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
++ F+ EC+LK+FALR++YF WN+FDFVVV+ SI+ + L+DIIEKYFVSPTL RV+R+
Sbjct: 1562 VIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGG 1695
A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LLLFLVMFIF+IFGMS F +VK + G
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAG 1681
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE-EECDLPDNERGS--PGNCGSATI 1752
+DD++NF+TF SMI LFQ++TSAGWDG+L I+N +C L GS G+CG+ ++
Sbjct: 1682 IDDMFNFETFGNSMICLFQIATSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSV 1741
Query: 1753 GITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQ 1812
GI + +SY++ISFLIV+NMYIA+ILEN+S ATE+ + L++DD++ +YEIW++FDPD +Q
Sbjct: 1742 GIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
Query: 1813 YIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN 1872
+I Y +L+DF D LE PL++ KPN ++I+MD+P+ GD + C+DIL A TK G
Sbjct: 1802 FIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGE 1861
Query: 1873 PIEETGDLE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+E P + YEP+++TL R++EE A ++Q
Sbjct: 1862 LDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ 1903
Score = 423 bits (1043), Expect = e-117
Identities = 221/410 (53%), Positives = 284/410 (69%), Gaps = 27/410 (6%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F+PFT ESL K+ +A+G R P+P++ LE G LP
Sbjct: 14 FKPFTPESLANIERRIAESKLKKPP----KADGSHREDDEDSK--PKPNSDLEAGKSLPF 67
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P L + PLED DP+Y Q TFVV+++GK +FRFSAT AL+IL PFN IRR+AI
Sbjct: 68 -IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAI 126
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
IL+H +FS+ I+ TIL NC+ M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 127 KILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDG 186
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 187 FTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 246
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDE----NWERF 310
SVK L DV+I+T+F LSVFAL+GLQ++ G + KCV V+P + + L + +WE +
Sbjct: 247 SVKKLSDVMIMTVFCLSVFALIGLQLFHGEPSNKCV-VWPINFNESYLENGTKGFDWEEY 305
Query: 311 CQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
N+TN+Y G + LCGNSS AGQC GY C++ G NPNYGYTSFDTF WAFL+ F
Sbjct: 306 INNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKA-GRNPNYGYTSFDTFSWAFLALF 364
Query: 369 RLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQL FFV++IF+GSFYLVNLILA+VAM+Y
Sbjct: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAY 414
Score = 171 bits (417), Expect = 2e-41
Identities = 85/178 (47%), Positives = 110/178 (61%), Gaps = 2/178 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 902
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 903 ECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMV 962
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK 1002
I D + N + + RI + + W K V F++
Sbjct: 963 IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ 1020
Score = 97.9 bits (233), Expect = 3e-19
Identities = 60/169 (35%), Positives = 95/169 (56%), Gaps = 10/169 (5%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + IV IV D D+ I + I LN L M ++H+ + F VL N++F IF
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIF 796
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LK+ A+ Y+YF E WN+FD +V S++ L L+D+ L V+R ++
Sbjct: 797 TAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADV--------EGLSVLRSFRL 848
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F
Sbjct: 849 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
Score = 84.6 bits (200), Expect = 3e-15
Identities = 52/193 (26%), Positives = 103/193 (53%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIM---PTTPTVES 168
++F+ T +W P+ ++ + I++ P L I I++N + M M P TP E
Sbjct: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783
Query: 169 T----EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + + + D+
Sbjct: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 899 KSYKECVCKINQD 911
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/201 (27%), Positives = 100/201 (49%), Gaps = 18/201 (8%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFK--LIENTYFETAVITMILLSSLALA 1236
CP C+ KF FL + P+W ++LK ++ + + + A+ I+L++L +A
Sbjct: 719 CPP-CWYKFANTFLIWECH-PYW-----IKLKEIVNLIVMDPFVDLAITICIVLNTLFMA 771
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
+E H P P + +L + +FT IF EM +K +A+ YF W D IV +SL
Sbjct: 772 ME--HHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSL 829
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
+ A ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 830 MELSLA-----DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 884
Query: 1357 FWLIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y +CV
Sbjct: 885 IVFIFAVVGMQLFGKSYKECV 905
Score = 77.4 bits (182), Expect = 5e-13
Identities = 40/113 (35%), Positives = 65/113 (57%), Gaps = 4/113 (3%)
Query: 719 VMVLNEIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCC 778
++V + + GR+ R + + +SV E+ E+ + K C K + F +W+C
Sbjct: 681 LLVSMDQLASYGRKDRINSI-MSVVTNTLVEELEES---QRKCPPCWYKFANTFLIWECH 736
Query: 779 WLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
W++ ++ V L+V DPFV+L IT+CIV+NTLFMA++HH M + L GN
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGN 789
Score = 77.4 bits (182), Expect = 5e-13
Identities = 69/291 (23%), Positives = 136/291 (46%), Gaps = 31/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FII IL++ + T T+ E + +FT I+ E
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-----GI-DLGNLAALRTFRVLR 234
+K A GF+ + +AW WLDF+++A++ V++ G +LG + +LRT R LR
Sbjct: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C
Sbjct: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCFNETS 1361
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
E + D N + C E G + GY+ L +
Sbjct: 1362 EIRF--EIEDVNNKTEC--EKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT-----F 1412
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q +E N+Y ++FV+ I GSF+ +NL + ++
Sbjct: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVI 1463
Score = 73.7 bits (173), Expect = 6e-12
Identities = 40/124 (32%), Positives = 73/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ ++ G + A +T
Sbjct: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YITEFVNLGNVSALRT 221
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGK-Y 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G+
Sbjct: 222 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMIMTVFCLSVFALIGLQLFHGEPS 278
Query: 1374 FKCV 1377
KCV
Sbjct: 279 NKCV 282
Score = 54.4 bits (125), Expect = 4e-06
Identities = 43/165 (26%), Positives = 79/165 (47%), Gaps = 20/165 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F MIIM I N + MT + +S ++Y F I++ E L+KI
Sbjct: 124 IAIKILIHSVFSMIIMCTILTNCVFMT---FSNPPDWSKNVEYT---FTGIYTFESLVKI 177
Query: 1588 FALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DF V+M + ++ FV+ + +R +V R L
Sbjct: 178 IARGFCIDGFTFLRDPWNWLDFSVIMMAYIT---------EFVNLGNVSALRTFRVLRAL 228
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+ + G++T++ AL S+ L ++ ++ + +FA+ G+ F
Sbjct: 229 KTISVIPGLKTIVGALIQSVKKLSDVMIMTVFCLSVFALIGLQLF 273
Score = 46.0 bits (104), Expect = 0.001
Identities = 39/169 (23%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P N I+ + + F + I+ I +N + M++ T + E ++F +T
Sbjct: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFT 1566
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K+ F L+ + Y WN DFVV+ L+ V M + D+ +R
Sbjct: 1567 CECVLKM----FALRHY-YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + +F++ G+
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM 1670
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/144 (20%), Positives = 66/144 (45%), Gaps = 6/144 (4%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +C + Y + ++ F + + L IV L ++ + + + + ++
Sbjct: 1564 FFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLAR 1623
Query: 832 YLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDR 891
R+ +L K + L+ + ++ AL N+ +L +++FIF++ GM F YV +
Sbjct: 1624 IGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHEAG 1681
Query: 892 FPDGDLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1682 IDD----MFNFETFGNSMICLFQI 1701
>AB027567-1|BAA78033.1| 1980|Homo sapiens sodium channel protein.
Length = 1980
Score = 831 bits (2055), Expect = 0.0
Identities = 409/762 (53%), Positives = 546/762 (71%), Gaps = 17/762 (2%)
Query: 1163 DIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFET 1222
++ V E+ +D P C E C Q+F + + + W LR F ++E+ +FET
Sbjct: 1145 EVPVEQPEEYLD--PDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFET 1202
Query: 1223 AVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTN 1282
+I MILLSS ALA ED+++ R ++ IL Y D++FT IF +EML+KW A GF K+FTN
Sbjct: 1203 FIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTN 1262
Query: 1283 AWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQ 1342
AWCWLDF+IV VSL++ +A G + A K++RTLRALRPLRA+SR +GMRVVVNALV
Sbjct: 1263 AWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1322
Query: 1343 AIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV-DMNHTTLSHEIIPDKNACT--LE- 1398
AIPSI NVLLVCLIFWLIF+IMGV LFAGKY C + + E + +K C +E
Sbjct: 1323 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEG 1382
Query: 1399 NYT---WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYL 1455
N T W+N +NFD+VG YL L QVATFKGW+ IM A+DSR+ QP E NIYMY+
Sbjct: 1383 NNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYI 1442
Query: 1456 YXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL 1515
Y TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP
Sbjct: 1443 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQ 1501
Query: 1516 KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIF 1575
K IPRP + Q IVF+ VT + FD++IM+ I LNM+TM ++ QS+ +L ++N++F
Sbjct: 1502 KPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVF 1561
Query: 1576 IVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
++ F+ EC+LK+FALR++YF WN+FDFVVV+ SI+ + L+DIIEKYFVSPTL RV+R+
Sbjct: 1562 VIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGG 1695
A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LLLFLVMFIF+IFGMS F +VK + G
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAG 1681
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE-EECDLPDNERGS--PGNCGSATI 1752
+DD++NF+TF SMI LFQ++TSAGWDG+L I+N +C L GS G+CG+ ++
Sbjct: 1682 IDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSV 1741
Query: 1753 GITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQ 1812
GI + +SY++ISFLIV+NMYIA+ILEN+S ATE+ + L++DD++ +YEIW++FDPD +Q
Sbjct: 1742 GIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
Query: 1813 YIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN 1872
+I Y +L+DF D LE PL++ KPN ++I+MD+P+ GD + C+DIL A TK G
Sbjct: 1802 FIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGE 1861
Query: 1873 PIEETGDLE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+E P + YEP+++TL R++EE A ++Q
Sbjct: 1862 LDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ 1903
Score = 429 bits (1056), Expect = e-119
Identities = 224/410 (54%), Positives = 285/410 (69%), Gaps = 27/410 (6%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F+PFT ESL K+ +A+G R P+P++ LE G LP
Sbjct: 14 FKPFTPESLANIERRIAESKLKKPP----KADGSHREDDEDSK--PKPNSDLEAGKSLPF 67
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P L + PLED DP+Y Q TFVV+++GK +FRFSAT AL+IL PFN IRR+AI
Sbjct: 68 -IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAI 126
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
IL+H +FS+ I+ TIL NC+ M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 127 KILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDG 186
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 187 FTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 246
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDE----NWERF 310
SVK L DV+ILT+F LSVFAL+GLQ++MG L KCV V+P + + L + +WE +
Sbjct: 247 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-VWPINFNESYLENGTKGFDWEEY 305
Query: 311 CQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
N+TN+Y G + LCGNSS AGQC GY C++ G NPNYGYTSFDTF WAFL+ F
Sbjct: 306 INNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKA-GRNPNYGYTSFDTFSWAFLALF 364
Query: 369 RLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQL FFV++IF+GSFYLVNLILA+VAM+Y
Sbjct: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAY 414
Score = 171 bits (417), Expect = 2e-41
Identities = 85/178 (47%), Positives = 110/178 (61%), Gaps = 2/178 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 902
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 903 ECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMV 962
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK 1002
I D + N + + RI + + W K V F++
Sbjct: 963 IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ 1020
Score = 97.9 bits (233), Expect = 3e-19
Identities = 60/169 (35%), Positives = 95/169 (56%), Gaps = 10/169 (5%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + IV IV D D+ I + I LN L M ++H+ + F VL N++F IF
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIF 796
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LK+ A+ Y+YF E WN+FD +V S++ L L+D+ L V+R ++
Sbjct: 797 TAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADV--------EGLSVLRSFRL 848
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F
Sbjct: 849 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
Score = 84.6 bits (200), Expect = 3e-15
Identities = 52/193 (26%), Positives = 103/193 (53%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIM---PTTPTVES 168
++F+ T +W P+ ++ + I++ P L I I++N + M M P TP E
Sbjct: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783
Query: 169 T----EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + + + D+
Sbjct: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 899 KSYKECVCKINQD 911
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/201 (27%), Positives = 100/201 (49%), Gaps = 18/201 (8%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFK--LIENTYFETAVITMILLSSLALA 1236
CP C+ KF FL + P+W ++LK ++ + + + A+ I+L++L +A
Sbjct: 719 CPP-CWYKFANTFLIWECH-PYW-----IKLKEIVNLIVMDPFVDLAITICIVLNTLFMA 771
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
+E H P P + +L + +FT IF EM +K +A+ YF W D IV +SL
Sbjct: 772 ME--HHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSL 829
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
+ A ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 830 MELSLA-----DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 884
Query: 1357 FWLIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y +CV
Sbjct: 885 IVFIFAVVGMQLFGKSYKECV 905
Score = 77.4 bits (182), Expect = 5e-13
Identities = 40/113 (35%), Positives = 65/113 (57%), Gaps = 4/113 (3%)
Query: 719 VMVLNEIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCC 778
++V + + GR+ R + + +SV E+ E+ + K C K + F +W+C
Sbjct: 681 LLVSMDQLASYGRKDRINSI-MSVVTNTLVEELEES---QRKCPPCWYKFANTFLIWECH 736
Query: 779 WLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
W++ ++ V L+V DPFV+L IT+CIV+NTLFMA++HH M + L GN
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGN 789
Score = 77.4 bits (182), Expect = 5e-13
Identities = 69/291 (23%), Positives = 136/291 (46%), Gaps = 31/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FII IL++ + T T+ E + +FT I+ E
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-----GI-DLGNLAALRTFRVLR 234
+K A GF+ + +AW WLDF+++A++ V++ G +LG + +LRT R LR
Sbjct: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C
Sbjct: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCFNETS 1361
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
E + D N + C E G + GY+ L +
Sbjct: 1362 EIRF--EIEDVNNKTEC--EKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT-----F 1412
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q +E N+Y ++FV+ I GSF+ +NL + ++
Sbjct: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVI 1463
Score = 74.1 bits (174), Expect = 5e-12
Identities = 40/124 (32%), Positives = 72/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ ++ G + A
Sbjct: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YITEFVNLGNVSA--- 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 278
Query: 1374 FKCV 1377
KCV
Sbjct: 279 NKCV 282
Score = 57.2 bits (132), Expect = 6e-07
Identities = 45/166 (27%), Positives = 80/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F MIIM I N + MT + +S ++Y F I++ E L+KI
Sbjct: 124 IAIKILIHSVFSMIIMCTILTNCVFMT---FSNPPDWSKNVEYT---FTGIYTFESLVKI 177
Query: 1588 FALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DF V+M + ++ FV+ + +R +V R L
Sbjct: 178 IARGFCIDGFTFLRDPWNWLDFSVIMMAYIT---------EFVNLGNVSALRTFRVLRAL 228
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 274
Score = 46.0 bits (104), Expect = 0.001
Identities = 39/169 (23%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P N I+ + + F + I+ I +N + M++ T + E ++F +T
Sbjct: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFT 1566
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K+ F L+ + Y WN DFVV+ L+ V M + D+ +R
Sbjct: 1567 CECVLKM----FALRHY-YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + +F++ G+
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM 1670
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/144 (20%), Positives = 66/144 (45%), Gaps = 6/144 (4%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +C + Y + ++ F + + L IV L ++ + + + + ++
Sbjct: 1564 FFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLAR 1623
Query: 832 YLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDR 891
R+ +L K + L+ + ++ AL N+ +L +++FIF++ GM F YV +
Sbjct: 1624 IGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHEAG 1681
Query: 892 FPDGDLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1682 IDD----MFNFETFGNSMICLFQI 1701
>AF050736-1|AAD15789.1| 1980|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 1980
Score = 830 bits (2054), Expect = 0.0
Identities = 408/762 (53%), Positives = 546/762 (71%), Gaps = 17/762 (2%)
Query: 1163 DIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFET 1222
++ V E+ +D P C E C Q+F + + + W LR F ++E+ +FET
Sbjct: 1145 EVPVEQPEEYLD--PDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFET 1202
Query: 1223 AVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTN 1282
+I MILLSS ALA ED+++ R ++ IL Y D++FT IF +EML+KW A GF K+FTN
Sbjct: 1203 FIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTN 1262
Query: 1283 AWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQ 1342
AWCWLDF+IV VSL++ +A G + A K++RTLRALRPLRA+SR +GMRVVVNALV
Sbjct: 1263 AWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1322
Query: 1343 AIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV-DMNHTTLSHEIIPDKNACT--LE- 1398
AIPSI NVLLVCLIFWLIF+IMGV LFAGKY C + + E + +K C +E
Sbjct: 1323 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEG 1382
Query: 1399 NYT---WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYL 1455
N T W+N +NFD+VG YL L QVATFKGW+ IM A+DSR+ QP E NIYMY+
Sbjct: 1383 NNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYI 1442
Query: 1456 YXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL 1515
Y TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP
Sbjct: 1443 YFIIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQ 1501
Query: 1516 KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIF 1575
K IPRP + Q IVF+ +T + FD++IM+ I LNM+TM ++ QS+ +L ++N++F
Sbjct: 1502 KPIPRPLNKIQGIVFDFITQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVF 1561
Query: 1576 IVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
++ F+ EC+LK+FALR++YF WN+FDFVVV+ SI+ + L+DIIEKYFVSPTL RV+R+
Sbjct: 1562 VIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGG 1695
A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LLLFLVMFIF+IFGMS F +VK + G
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAG 1681
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE-EECDLPDNERGS--PGNCGSATI 1752
+DD++NF+TF SMI LFQ++TSAGWDG+L I+N +C L GS G+CG+ ++
Sbjct: 1682 IDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSV 1741
Query: 1753 GITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQ 1812
GI + +SY++ISFLIV+NMYIA+ILEN+S ATE+ + L++DD++ +YEIW++FDPD +Q
Sbjct: 1742 GIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
Query: 1813 YIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN 1872
+I Y +L+DF D LE PL++ KPN ++I+MD+P+ GD + C+DIL A TK G
Sbjct: 1802 FIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGE 1861
Query: 1873 PIEETGDLE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+E P + YEP+++TL R++EE A ++Q
Sbjct: 1862 LDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ 1903
Score = 432 bits (1065), Expect = e-120
Identities = 227/410 (55%), Positives = 285/410 (69%), Gaps = 27/410 (6%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F+PFT ESL K+ +A+G R P+P++ LE G LP
Sbjct: 14 FKPFTPESLANIERRIAESKLKKPP----KADGSHREDDEDSK--PKPNSDLEAGKSLPF 67
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P L + PLED DP+Y Q TFVV+++GK +FRFSAT AL+IL PFN IRR+AI
Sbjct: 68 -IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAI 126
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
IL+H LFS+ I+ TIL NC+ M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 127 KILIHSLFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDG 186
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 187 FTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 246
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDE----NWERF 310
SVK L DV+ILT+F LSVFAL+GLQ++MG L KCV V+P + + L + +WE +
Sbjct: 247 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-VWPINFNESYLENGTKGFDWEEY 305
Query: 311 CQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
N+TN+Y G + LCGNSS AGQC GY C++ G NPNYGYTSFDTF WAFL+ F
Sbjct: 306 INNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKA-GRNPNYGYTSFDTFSWAFLALF 364
Query: 369 RLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQL FFV++IF+GSFYLVNLILA+VAM+Y
Sbjct: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAY 414
Score = 171 bits (417), Expect = 2e-41
Identities = 85/178 (47%), Positives = 110/178 (61%), Gaps = 2/178 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 902
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 903 ECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMV 962
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK 1002
I D + N + + RI + + W K V F++
Sbjct: 963 IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ 1020
Score = 97.9 bits (233), Expect = 3e-19
Identities = 60/169 (35%), Positives = 95/169 (56%), Gaps = 10/169 (5%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + IV IV D D+ I + I LN L M ++H+ + F VL N++F IF
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIF 796
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LK+ A+ Y+YF E WN+FD +V S++ L L+D+ L V+R ++
Sbjct: 797 TAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADV--------EGLSVLRSFRL 848
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F
Sbjct: 849 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
Score = 84.6 bits (200), Expect = 3e-15
Identities = 52/193 (26%), Positives = 103/193 (53%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIM---PTTPTVES 168
++F+ T +W P+ ++ + I++ P L I I++N + M M P TP E
Sbjct: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783
Query: 169 T----EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + + + D+
Sbjct: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 899 KSYKECVCKINQD 911
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/201 (27%), Positives = 100/201 (49%), Gaps = 18/201 (8%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFK--LIENTYFETAVITMILLSSLALA 1236
CP C+ KF FL + P+W ++LK ++ + + + A+ I+L++L +A
Sbjct: 719 CPP-CWYKFANTFLIWECH-PYW-----IKLKEIVNLIVMDPFVDLAITICIVLNTLFMA 771
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
+E H P P + +L + +FT IF EM +K +A+ YF W D IV +SL
Sbjct: 772 ME--HHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSL 829
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
+ A ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 830 MELSLA-----DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 884
Query: 1357 FWLIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y +CV
Sbjct: 885 IVFIFAVVGMQLFGKSYKECV 905
Score = 77.4 bits (182), Expect = 5e-13
Identities = 40/113 (35%), Positives = 65/113 (57%), Gaps = 4/113 (3%)
Query: 719 VMVLNEIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCC 778
++V + + GR+ R + + +SV E+ E+ + K C K + F +W+C
Sbjct: 681 LLVSMDQLASYGRKDRINSI-MSVVTNTLVEELEES---QRKCPPCWYKFANTFLIWECH 736
Query: 779 WLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
W++ ++ V L+V DPFV+L IT+CIV+NTLFMA++HH M + L GN
Sbjct: 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGN 789
Score = 77.0 bits (181), Expect = 6e-13
Identities = 68/291 (23%), Positives = 136/291 (46%), Gaps = 31/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FII IL++ + T T+ E + +FT I+ E
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-----GI-DLGNLAALRTFRVLR 234
+K A GF+ + +AW WLDF+++A++ V++ G +LG + +LRT R LR
Sbjct: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C
Sbjct: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCFNETS 1361
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
E + D N + C E G + GY+ L +
Sbjct: 1362 EIRF--EIEDVNNKTEC--EKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT-----F 1412
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q +E N+Y ++F++ I GSF+ +NL + ++
Sbjct: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFIIFIIFGSFFTLNLFIGVI 1463
Score = 74.1 bits (174), Expect = 5e-12
Identities = 41/124 (33%), Positives = 72/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ +V G + A
Sbjct: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YVTEFVDLGNVSA--- 218
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 219 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 278
Query: 1374 FKCV 1377
KCV
Sbjct: 279 NKCV 282
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 79/166 (47%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F MIIM I N + MT + +S ++Y F I++ E L+KI
Sbjct: 124 IAIKILIHSLFSMIIMCTILTNCVFMT---FSNPPDWSKNVEYT---FTGIYTFESLVKI 177
Query: 1588 FALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DF V+M + ++ FV + +R +V R L
Sbjct: 178 IARGFCIDGFTFLRDPWNWLDFSVIMMAYVT---------EFVDLGNVSALRTFRVLRAL 228
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 274
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/169 (23%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P N I+ + + F + I+ I +N + M++ T + E ++F +T
Sbjct: 1507 PLNKIQGIVFDFITQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFT 1566
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K+ F L+ + Y WN DFVV+ L+ V M + D+ +R
Sbjct: 1567 CECVLKM----FALRHY-YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + +F++ G+
Sbjct: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM 1670
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/144 (20%), Positives = 66/144 (45%), Gaps = 6/144 (4%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +C + Y + ++ F + + L IV L ++ + + + + ++
Sbjct: 1564 FFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLAR 1623
Query: 832 YLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDR 891
R+ +L K + L+ + ++ AL N+ +L +++FIF++ GM F YV +
Sbjct: 1624 IGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHEAG 1681
Query: 892 FPDGDLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1682 IDD----MFNFETFGNSMICLFQI 1701
>DQ784809-1|ABQ01244.1| 2016|Homo sapiens sodium channel protein type
V alpha subunit protein.
Length = 2016
Score = 828 bits (2047), Expect = 0.0
Identities = 407/755 (53%), Positives = 537/755 (71%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1159 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1216
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1217 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1276
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1277 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1336
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1337 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1396
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1397 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1456
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK G ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1457 GSFFTLNLFIGVIIDNFNQQKKKIRGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1515
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1516 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1575
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1576 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1635
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1636 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1695
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1696 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1754
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1755 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1814
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1815 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1874
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1875 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1909
Score = 407 bits (1003), Expect = e-112
Identities = 216/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LRD WNWLDF VI +AY T +DLGN++ALRTFRVLRALKT++++ GLKTIVGA+
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 980
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1368
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1369 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1426
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1427 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 654 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 708
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 709 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 53.2 bits (122), Expect = 9e-06
Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F +PWN DF V++ + + FV + +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EFVDLGNVSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1573 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1676
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1599 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1658
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1659 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1707
>AF225987-1|AAK00219.1| 2000|Homo sapiens voltage-gated sodium channel
alpha subunit SCN3A protein.
Length = 2000
Score = 827 bits (2045), Expect = 0.0
Identities = 407/750 (54%), Positives = 540/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1162 DFKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1221
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1222 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1281
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1282 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1341
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1342 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1399
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1400 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1459
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1460 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1518
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1519 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1578
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKY VSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1579 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRLIKGA 1638
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1639 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1698
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+ G ++GI + +SY++IS
Sbjct: 1699 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDRGDPSVGIFFFVSYIIIS 1758
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1759 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1818
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1819 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLCESGEMDALRIQMEDRF 1878
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1879 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1908
Score = 431 bits (1061), Expect = e-119
Identities = 227/426 (53%), Positives = 294/426 (69%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 830 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 887
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 888 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 947
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 948 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 1007
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 1008 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1056
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 816 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 867
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 926
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 927 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 969
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 970 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1001
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1367
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1368 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1418
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1419 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1467
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 731 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 790
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 791 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 846
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 847 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 905
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 906 KSYKECVCKINDD 918
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 694 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 748
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 749 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 796
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 813
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 814 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 868
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 869 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 912
Score = 72.5 bits (170), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 55.2 bits (127), Expect = 2e-06
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FV + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 42.7 bits (96), Expect = 0.013
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1570
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1571 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRL 1625
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1626 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1674
Score = 39.5 bits (88), Expect = 0.12
Identities = 29/140 (20%), Positives = 69/140 (49%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ +++ + + ++ R+ +L K + L+ + ++
Sbjct: 1594 FVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1653
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1654 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1706
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1707 ---TSAGWDGLLAPILNSAP 1723
>AF225986-1|AAK00218.1| 1951|Homo sapiens voltage-gated sodium channel
alpha subunit splice variant SCN3A-s protein.
Length = 1951
Score = 827 bits (2045), Expect = 0.0
Identities = 407/750 (54%), Positives = 540/750 (72%), Gaps = 16/750 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DFKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA---CTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR+V QP+ E N+YMYLY T
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGM 1469
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ Q + + VL +N++FIV+F+ E +LK+
Sbjct: 1470 VFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1529
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKY VSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1530 SLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRLIKGA 1589
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1590 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNS 1649
Query: 1709 MILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N +CD GS G+ G ++GI + +SY++IS
Sbjct: 1650 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDRGDPSVGIFFFVSYIIIS 1709
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF
Sbjct: 1710 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA 1769
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1770 ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLCESGEMDALRIQMEDRF 1829
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R++EE A +IQ
Sbjct: 1830 MASNPSKVSYEPITTTLKRKQEEVSAAIIQ 1859
Score = 431 bits (1061), Expect = e-119
Identities = 227/426 (53%), Positives = 294/426 (69%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ + +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 180 bits (437), Expect = 6e-44
Identities = 94/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLD 1031
R+ + ID++K + + + + I IH ++D+ + T ++
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIE 1007
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/293 (25%), Positives = 142/293 (48%), Gaps = 39/293 (13%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ---NETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPN 351
G+ +++D N CQ + W ++ ++ GA GY+ L
Sbjct: 1319 TTGNMFDISDVNNLSDCQALGKQARWKNVKVNF----DNVGA-----GYLALLQVATFKG 1369
Query: 352 YGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D A S + Y ENLY L+FV+ I GSF+ +NL + ++
Sbjct: 1370 W----MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1418
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 72.5 bits (170), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A
Sbjct: 161 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 55.2 bits (127), Expect = 2e-06
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FV + +R +V R L
Sbjct: 174 LARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 42.7 bits (96), Expect = 0.013
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1522 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRL 1576
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1625
Score = 39.5 bits (88), Expect = 0.12
Identities = 29/140 (20%), Positives = 69/140 (49%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ +++ + + ++ R+ +L K + L+ + ++
Sbjct: 1545 FVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1604
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 1605 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 1657
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 1658 ---TSAGWDGLLAPILNSAP 1674
>AB158470-1|BAD12085.1| 1962|Homo sapiens TTX-resistant sodium channel
splicing variant protein.
Length = 1962
Score = 826 bits (2043), Expect = 0.0
Identities = 406/755 (53%), Positives = 536/755 (70%), Gaps = 18/755 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 1105 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 1162
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 1163 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 1222
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 1223 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1282
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 1283 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1342
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QVATFKGW+ IM A+DSR QP E N+YMY+Y
Sbjct: 1343 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1402
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKK GG ++FMTE+QKKYYNA KK+GSKKP K IPRP
Sbjct: 1403 GSFFTLNLFIGVIIDNFNQQKKTLGGQ-DIFMTEEQKKYYNATKKLGSKKPQKPIPRPLN 1461
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1462 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1521
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LR
Sbjct: 1522 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1581
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1582 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1641
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1642 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1700
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1701 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1760
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1761 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1820
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1821 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1855
Score = 408 bits (1004), Expect = e-112
Identities = 217/414 (52%), Positives = 276/414 (66%), Gaps = 28/414 (6%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAV 252
FT+LR WNWLDF VI +AYV+ I LGNL+ALRTFRVLRALKT++++PGLKTIVGA+
Sbjct: 184 HAFTFLRGPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGAL 243
Query: 253 IESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WER 309
I+SVK L DV++LT+F LSVFAL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 244 IQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWES 303
Query: 310 ---FCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAF 364
+ + N+ + G D LCGNSS AG C GY CL+ G NP++GYTSFD+F WAF
Sbjct: 304 LDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKA-GENPDHGYTSFDSFAWAF 362
Query: 365 LSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
L+ FRLMTQD WE LYQ +FF+++IFLGSFYLVNLILA+VAM+Y
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY 416
Score = 177 bits (432), Expect = 2e-43
Identities = 92/192 (47%), Positives = 117/192 (60%), Gaps = 3/192 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 867 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 925
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF-LKLL 1004
P D++ N + A RI R + ++KR DF LL
Sbjct: 926 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL 985
Query: 1005 KNKLTNQIAIHA 1016
+++ A+ A
Sbjct: 986 RHRPQKPAALAA 997
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 772
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 773 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 824
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 884
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 885 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 927
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 928 LVVLNLFLALLLSSFS 943
Score = 86.6 bits (205), Expect = 8e-16
Identities = 73/291 (25%), Positives = 142/291 (48%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTE 1314
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
D N T N + C++ N GE + N G + + F + Y
Sbjct: 1315 GDLPL-NYTIVNNKSQCES-LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1372
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ D+ G+ Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 1373 AAVDSRGYE--------EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1415
Score = 81.8 bits (193), Expect = 2e-14
Identities = 41/106 (38%), Positives = 63/106 (59%), Gaps = 5/106 (4%)
Query: 726 IEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQ 785
+E+ G + RA VSV E +E + K C + + +W+CC LW+ +
Sbjct: 653 VEEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIK 707
Query: 786 KYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 708 QGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
Score = 77.4 bits (182), Expect = 5e-13
Identities = 47/137 (34%), Positives = 81/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT W WLDF +++++ +V+ G +
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRGPWNWLDFSVIIMA---YVSENIKLGNL 215
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 216 SA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 273 MGNLRHKCV-RNFTALN 288
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 748
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 749 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 804
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 805 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 711 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 768
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 769 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 823
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 824 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 870
Score = 50.8 bits (116), Expect = 5e-05
Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 20/163 (12%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+I+ F+M+IM I N + M H T Y+ F I++ E L+KI A
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLVKILAR 179
Query: 1591 RY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
+ H F PWN DF V++ + +S E + L +R +V R L+ +
Sbjct: 180 GFCLHAFTFLRGPWNWLDFSVIIMAYVS-------ENIKLGN--LSALRTFRVLRALKTI 230
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 273
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1459 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1518
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1519 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1573
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1574 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1622
Score = 35.9 bits (79), Expect = 1.5
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + + + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1545 VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1604
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1605 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1653
>X82835-1|CAA58042.1| 1977|Homo sapiens sodium channel alpha subunit
protein.
Length = 1977
Score = 825 bits (2040), Expect = 0.0
Identities = 395/755 (52%), Positives = 547/755 (72%), Gaps = 15/755 (1%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E + D P C + C ++F + +S + W +R +K++E+++FE+ ++ MIL
Sbjct: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED+++ + ++ IL Y D+IFT IF +EML+KW+A G++ YFTNAWCWLDF
Sbjct: 1193 LSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDF 1252
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI N
Sbjct: 1253 LIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMN 1312
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH-TTLSHEIIPDKNAC-----TLENYTWE 1403
VLLVCLIFWLIF+IMGV LFAGK+++C++ + +P+++ C +N W+
Sbjct: 1313 VLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWK 1372
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
N +NFD+VG YL L QVATFKGW IM A+DS V +QP E ++YMY+Y
Sbjct: 1373 NLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIF 1432
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1433 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1491
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F++VT++ FD+ IM+ I LNM+TM ++ QS+ + VL ++N++FI++F+ EC
Sbjct: 1492 KIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGEC 1551
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
+LK+ +LR++YF WN+FDFVVV+ SI+ + L+D+IE YFVSPTL RV+R+A++GR+LR
Sbjct: 1552 VLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
LVKGAKGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G++D++NF+
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFE 1671
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLS 1759
TF SMI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI Y +S
Sbjct: 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1731
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +L
Sbjct: 1732 YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1791
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGD 1879
SDF L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G
Sbjct: 1792 SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQ 1851
Query: 1880 LE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+E P + YEP+++TL R++E+ A +IQ
Sbjct: 1852 MEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQ 1886
Score = 412 bits (1014), Expect = e-114
Identities = 218/410 (53%), Positives = 283/410 (69%), Gaps = 34/410 (8%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FT++SL K+ + EKK + E P+P + LE G LP
Sbjct: 12 FVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEA----------PKPSSDLEAGKQLPF 61
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P + S PLED+DP+Y ++ TF+V++KGK IFRF+AT AL++L PF+P+RR++I
Sbjct: 62 -IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NCI M M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDFVVI AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNE 314
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC + E+ N T E+ ++E
Sbjct: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN----NETLESIMNTLESE 296
Query: 315 TN-----WYGEGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
+ +Y EG D LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ F
Sbjct: 297 EDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALF 355
Query: 369 RLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQ +FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405
Score = 177 bits (432), Expect = 2e-43
Identities = 94/208 (45%), Positives = 125/208 (60%), Gaps = 10/208 (4%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRT 855
F L +TL +V LF+A D + L+S LRVFKLAKSWPTLN+LI I+G +
Sbjct: 800 FDSLIVTLSLV--ELFLA------DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 851
Query: 856 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFR 914
+GALGNLT VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFR
Sbjct: 852 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFR 911
Query: 915 VLCGEWIESMWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTAD 973
VLCGEWIE+MWDCM + G C+ ++ +VI D
Sbjct: 912 VLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEED 971
Query: 974 QDTNKIAEAFNRISRFIDWIKRNVADFL 1001
D N + A RI + I+++K+ + +F+
Sbjct: 972 PDANNLQIAVTRIKKGINYVKQTLREFI 999
Score = 98.7 bits (235), Expect = 2e-19
Identities = 80/271 (29%), Positives = 138/271 (50%), Gaps = 36/271 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + ++ IV D D+ I + I LN L M ++H+ +E F VL N++F IF
Sbjct: 717 PYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E +LK+ A+ Y YF WN+FD ++V S++ L L+D+ L V+R ++
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV--------EGLSVLRSFRL 828
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHV 1690
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F +
Sbjct: 829 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 888
Query: 1691 KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSA 1750
D L ++ F S +++F+ VL G E D + G A
Sbjct: 889 NDDCTLPR-WHMNDFFHSFLIVFR---------VLCGEWIETMWDCME-------VAGQA 931
Query: 1751 TIGITYLLSYLVISFLIVINMYIAVILENYS 1781
I Y++ +VI L+V+N+++A++L ++S
Sbjct: 932 MCLIVYMM-VMVIGNLVVLNLFLALLLSSFS 961
Score = 81.0 bits (191), Expect = 4e-14
Identities = 75/291 (25%), Positives = 137/291 (47%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNC-------ILMIMPTTPTV--ESTEVIFTGIYTFE 180
IR+ I+ H F FI+ IL++ I + T + E + IFT I+ E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ VT+ DLG + +LRT R LR
Sbjct: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A+I ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YECINT-- 1342
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
DGS + C N L N G GY+ L +
Sbjct: 1343 TDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGL---GYLSLLQVAT-----F 1394
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q +E +LY ++FVV I GSF+ +NL + ++
Sbjct: 1395 KGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1445
Score = 79.8 bits (188), Expect = 9e-14
Identities = 50/193 (25%), Positives = 99/193 (51%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W P+ ++ +I++ P L I I++N + M M P E +
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+ E +K++A + P+ Y + WN D +++ L+ V + + D+
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 879 KSYKECVCKINDD 891
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/174 (25%), Positives = 90/174 (51%), Gaps = 7/174 (4%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W + + ++ + + + A+ I+L++L +A+E H P +++L + +FT IF
Sbjct: 719 WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME--HHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
EM++K +A+ +YF W D +IV +SL+ A ++ +R+ R LR
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA-----DVEGLSVLRSFRLLRV 831
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+ + +++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 885
Score = 75.4 bits (177), Expect = 2e-12
Identities = 29/60 (48%), Positives = 43/60 (71%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +W+C W++F+K + +V DPFV+L IT+CIV+NTLFMA++HH M ++ L GN
Sbjct: 710 FLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN 769
Score = 73.3 bits (172), Expect = 8e-12
Identities = 46/175 (26%), Positives = 92/175 (52%), Gaps = 19/175 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + K++ ++ F ++ IL + + + + + D ++ FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP--------PDWTKNVEYTFTGIYTFE 166
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
L+K LA GF + + W WLDF++++ + ++ G + A +T R LRAL+
Sbjct: 167 SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSALRTFRVLRALK 223
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKC 1376
+ S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KC
Sbjct: 224 TI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC 275
Score = 61.3 bits (142), Expect = 3e-08
Identities = 50/188 (26%), Positives = 94/188 (50%), Gaps = 21/188 (11%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+++ ++ ++Y F I++ E L+KI
Sbjct: 118 ISIKILVHSLFSMLIMCTILTNCIFMTMNN---PPDWTKNVEYT---FTGIYTFESLVKI 171
Query: 1588 FAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DFVV++F+ L+ FV+ + +R +V R L
Sbjct: 172 LARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGNVSALRTFRVLRAL 222
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM-HVKDKGGLDDVYN 1701
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM ++K K + + N
Sbjct: 223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN 282
Query: 1702 FKTFVQSM 1709
+T M
Sbjct: 283 NETLESIM 290
Score = 41.5 bits (93), Expect = 0.029
Identities = 39/169 (23%), Positives = 81/169 (47%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N I+ ++ + F + I+ I +N + M++ T + V+F ++T
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFT 1548
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K+++ L+ + Y WN DFVV+ ++ V M + DL +R
Sbjct: 1549 GECVLKLIS----LRHY-YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRL 1603
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ V G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1604 ARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/118 (22%), Positives = 61/118 (51%), Gaps = 8/118 (6%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + I + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1572 FVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLP 1631
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
AL N+ +L +++FI+A+ GM F YV + DG +NF F +S + +F++
Sbjct: 1632 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKK-EDGINDMFNFETFGNSMICLFQI 1683
>DQ857292-1|ABI51981.1| 1977|Homo sapiens voltage-gated sodium channel
Nav1.7 protein.
Length = 1977
Score = 825 bits (2040), Expect = 0.0
Identities = 395/755 (52%), Positives = 547/755 (72%), Gaps = 15/755 (1%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E + D P C + C ++F + +S + W +R +K++E+++FE+ ++ MIL
Sbjct: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED+++ + ++ IL Y D+IFT IF +EML+KW+A G++ YFTNAWCWLDF
Sbjct: 1193 LSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDF 1252
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI N
Sbjct: 1253 LIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMN 1312
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH-TTLSHEIIPDKNAC-----TLENYTWE 1403
VLLVCLIFWLIF+IMGV LFAGK+++C++ + +P+++ C +N W+
Sbjct: 1313 VLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWK 1372
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
N +NFD+VG YL L QVATFKGW IM A+DS V +QP E ++YMY+Y
Sbjct: 1373 NLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIF 1432
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1433 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1491
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F++VT++ FD+ IM+ I LNM+TM ++ QS+ + VL ++N++FI++F+ EC
Sbjct: 1492 KIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGEC 1551
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
+LK+ +LR++YF WN+FDFVVV+ SI+ + L+D+IE YFVSPTL RV+R+A++GR+LR
Sbjct: 1552 VLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
LVKGAKGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G++D++NF+
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFE 1671
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLS 1759
TF SMI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI Y +S
Sbjct: 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1731
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +L
Sbjct: 1732 YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1791
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGD 1879
SDF L+PPL I KPNK ++I+MD+P+ GD + C+DIL A TK G
Sbjct: 1792 SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQ 1851
Query: 1880 LE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
+E P + YEP+++TL R++E+ A +IQ
Sbjct: 1852 MEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQ 1886
Score = 412 bits (1014), Expect = e-114
Identities = 218/410 (53%), Positives = 283/410 (69%), Gaps = 34/410 (8%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FT++SL K+ + EKK + E P+P + LE G LP
Sbjct: 12 FVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEA----------PKPSSDLEAGKQLPF 61
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P + S PLED+DP+Y ++ TF+V++KGK IFRF+AT AL++L PF+P+RR++I
Sbjct: 62 -IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NCI M M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDFVVI AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNE 314
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC + E+ N T E+ ++E
Sbjct: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN----NETLESIMNTLESE 296
Query: 315 TN-----WYGEGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
+ +Y EG D LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ F
Sbjct: 297 EDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALF 355
Query: 369 RLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQ +FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405
Score = 177 bits (432), Expect = 2e-43
Identities = 94/208 (45%), Positives = 125/208 (60%), Gaps = 10/208 (4%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRT 855
F L +TL +V LF+A D + L+S LRVFKLAKSWPTLN+LI I+G +
Sbjct: 800 FDSLIVTLSLV--ELFLA------DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 851
Query: 856 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFR 914
+GALGNLT VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFR
Sbjct: 852 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFR 911
Query: 915 VLCGEWIESMWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTAD 973
VLCGEWIE+MWDCM + G C+ ++ +VI D
Sbjct: 912 VLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEED 971
Query: 974 QDTNKIAEAFNRISRFIDWIKRNVADFL 1001
D N + A RI + I+++K+ + +F+
Sbjct: 972 PDANNLQIAVTRIKKGINYVKQTLREFI 999
Score = 98.7 bits (235), Expect = 2e-19
Identities = 80/271 (29%), Positives = 138/271 (50%), Gaps = 36/271 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + ++ IV D D+ I + I LN L M ++H+ +E F VL N++F IF
Sbjct: 717 PYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E +LK+ A+ Y YF WN+FD ++V S++ L L+D+ L V+R ++
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV--------EGLSVLRSFRL 828
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHV 1690
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F +
Sbjct: 829 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 888
Query: 1691 KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSA 1750
D L ++ F S +++F+ VL G E D + G A
Sbjct: 889 NDDCTLPR-WHMNDFFHSFLIVFR---------VLCGEWIETMWDCME-------VAGQA 931
Query: 1751 TIGITYLLSYLVISFLIVINMYIAVILENYS 1781
I Y++ +VI L+V+N+++A++L ++S
Sbjct: 932 MCLIVYMM-VMVIGNLVVLNLFLALLLSSFS 961
Score = 81.0 bits (191), Expect = 4e-14
Identities = 75/291 (25%), Positives = 137/291 (47%), Gaps = 32/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNC-------ILMIMPTTPTV--ESTEVIFTGIYTFE 180
IR+ I+ H F FI+ IL++ I + T + E + IFT I+ E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ VT+ DLG + +LRT R LR
Sbjct: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A+I ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YECINT-- 1342
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
DGS + C N L N G GY+ L +
Sbjct: 1343 TDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGL---GYLSLLQVAT-----F 1394
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q +E +LY ++FVV I GSF+ +NL + ++
Sbjct: 1395 KGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1445
Score = 79.8 bits (188), Expect = 9e-14
Identities = 50/193 (25%), Positives = 99/193 (51%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W P+ ++ +I++ P L I I++N + M M P E +
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+ E +K++A + P+ Y + WN D +++ L+ V + + D+
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 879 KSYKECVCKINDD 891
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/174 (25%), Positives = 90/174 (51%), Gaps = 7/174 (4%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W + + ++ + + + A+ I+L++L +A+E H P +++L + +FT IF
Sbjct: 719 WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME--HHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
EM++K +A+ +YF W D +IV +SL+ A ++ +R+ R LR
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA-----DVEGLSVLRSFRLLRV 831
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+ + +++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 885
Score = 75.4 bits (177), Expect = 2e-12
Identities = 29/60 (48%), Positives = 43/60 (71%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +W+C W++F+K + +V DPFV+L IT+CIV+NTLFMA++HH M ++ L GN
Sbjct: 710 FLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN 769
Score = 73.3 bits (172), Expect = 8e-12
Identities = 46/175 (26%), Positives = 92/175 (52%), Gaps = 19/175 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + K++ ++ F ++ IL + + + + + D ++ FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP--------PDWTKNVEYTFTGIYTFE 166
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
L+K LA GF + + W WLDF++++ + ++ G + A +T R LRAL+
Sbjct: 167 SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSALRTFRVLRALK 223
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKC 1376
+ S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KC
Sbjct: 224 TI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC 275
Score = 61.3 bits (142), Expect = 3e-08
Identities = 50/188 (26%), Positives = 94/188 (50%), Gaps = 21/188 (11%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+++ ++ ++Y F I++ E L+KI
Sbjct: 118 ISIKILVHSLFSMLIMCTILTNCIFMTMNN---PPDWTKNVEYT---FTGIYTFESLVKI 171
Query: 1588 FAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DFVV++F+ L+ FV+ + +R +V R L
Sbjct: 172 LARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGNVSALRTFRVLRAL 222
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM-HVKDKGGLDDVYN 1701
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM ++K K + + N
Sbjct: 223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN 282
Query: 1702 FKTFVQSM 1709
+T M
Sbjct: 283 NETLESIM 290
Score = 41.5 bits (93), Expect = 0.029
Identities = 39/169 (23%), Positives = 81/169 (47%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N I+ ++ + F + I+ I +N + M++ T + V+F ++T
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFT 1548
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRT 229
E +K+++ L+ + Y WN DFVV+ ++ V M + DL +R
Sbjct: 1549 GECVLKLIS----LRHY-YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRL 1603
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ V G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1604 ARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/118 (22%), Positives = 61/118 (51%), Gaps = 8/118 (6%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + I + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 1572 FVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLP 1631
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
AL N+ +L +++FI+A+ GM F YV + DG +NF F +S + +F++
Sbjct: 1632 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKK-EDGINDMFNFETFGNSMICLFQI 1683
>AY043484-1|AAK95360.1| 1998|Homo sapiens voltage-gated sodium channel
type I protein.
Length = 1998
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1166 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1225
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1226 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1285
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1286 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1345
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1346 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1403
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1404 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1463
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1464 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1522
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1523 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1582
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1583 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1702
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1703 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1762
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1763 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1822
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1823 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1882
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1883 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1912
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 179 bits (436), Expect = 8e-44
Identities = 88/191 (46%), Positives = 120/191 (62%), Gaps = 5/191 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 847 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 906
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
D V + D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 907 DCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMV 966
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK-- 1002
I D + N + A +R+ + + ++KR + +F++
Sbjct: 967 IGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1026
Query: 1003 -LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1027 FIRKQKILDEI 1037
Score = 101 bits (241), Expect = 3e-20
Identities = 87/287 (30%), Positives = 147/287 (51%), Gaps = 38/287 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 741 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 800
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 801 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 852
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F KD K
Sbjct: 853 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 912
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D E C
Sbjct: 913 ASDCQLPRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC---- 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 958 --LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 998
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALE 1238
CP C+ KF FL D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 723 CPP-CWYKFSNIFLIWDC-SPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME 777
Query: 1239 DVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLIN 1298
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 778 --HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
Query: 1299 FVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1358
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 836 L-----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 890
Query: 1359 LIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 891 FIFAVVGMQLFGKSYKDCV 909
Score = 80.6 bits (190), Expect = 5e-14
Identities = 49/187 (26%), Positives = 97/187 (51%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS +W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902
Query: 284 VLTQKCV 290
+ CV
Sbjct: 903 KSYKDCV 909
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1368
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1369 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1423
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1424 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1471
Score = 77.8 bits (183), Expect = 4e-13
Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
+ +E ++ RA ++++ T E+ E+ ++K C K + F +WDC WL+
Sbjct: 691 DFLEDPSQRQRA--MSIASILTNTVEELEES---RQKCPPCWYKFSNIFLIWDCSPYWLK 745
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 746 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGN 793
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1574
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1575 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1629
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1630 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1678
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1576 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1635
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1636 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1690
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1691 D-DMFNFETFGNSMICLFQI 1709
>AF225985-1|AAK00217.1| 1999|Homo sapiens voltage-gated sodium channel
alpha subunit SCN1A protein.
Length = 1999
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1167 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1226
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1227 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1286
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1347 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1404
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1405 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1464
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1465 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1523
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1524 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1583
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1584 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1703
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1704 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1763
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1764 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1823
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1824 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1883
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1884 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1913
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 175 bits (425), Expect = 2e-42
Identities = 88/192 (45%), Positives = 120/192 (62%), Gaps = 6/192 (3%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 847 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 906
Query: 887 DYVDRF-PDGDLP-RWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATV 943
D V + D LP RW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +
Sbjct: 907 DCVCKIASDCQLPQRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVM 966
Query: 944 VIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK- 1002
VI D + N + A +R+ + + ++KR + +F++
Sbjct: 967 VIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQ 1026
Query: 1003 --LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1027 SFIRKQKILDEI 1038
Score = 101 bits (242), Expect = 3e-20
Identities = 84/288 (29%), Positives = 145/288 (50%), Gaps = 39/288 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 741 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 800
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 801 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 852
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHV 1690
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F +
Sbjct: 853 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 912
Query: 1691 KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSA 1750
L ++ F S +++F+ VL G E D E C
Sbjct: 913 ASDCQLPQRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC--- 958
Query: 1751 TIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 959 ---LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 999
Score = 81.4 bits (192), Expect = 3e-14
Identities = 49/187 (26%), Positives = 98/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS ++W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 728 YKFSNIFSIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902
Query: 284 VLTQKCV 290
+ CV
Sbjct: 903 KSYKDCV 909
Score = 80.6 bits (190), Expect = 5e-14
Identities = 53/198 (26%), Positives = 96/198 (48%), Gaps = 12/198 (6%)
Query: 1181 CPEQCYQKFPFLAGD-DDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALED 1239
CP C+ KF + D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 723 CPP-CWYKFSNIFSIWDCSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME- 777
Query: 1240 VHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 778 -HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVEL 836
Query: 1300 VAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWL 1359
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 837 -----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 891
Query: 1360 IFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 892 IFAVVGMQLFGKSYKDCV 909
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1197 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1256
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1369
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1370 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1424
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1425 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Score = 77.8 bits (183), Expect = 4e-13
Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
+ +E ++ RA ++++ T E+ E+ ++K C K + F +WDC WL+
Sbjct: 691 DFLEDPSQRQRA--MSIASILTNTVEELEES---RQKCPPCWYKFSNIFSIWDCSPYWLK 745
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 746 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGN 793
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1516 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1575
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1576 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1577 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1636
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1637 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1691
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1692 D-DMFNFETFGNSMICLFQI 1710
>AC010127-1|AAX81984.1| 1998|Homo sapiens unknown protein.
Length = 1998
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1166 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1225
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1226 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1285
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1286 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1345
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1346 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1403
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1404 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1463
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1464 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1522
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1523 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1582
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1583 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1702
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1703 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1762
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1763 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1822
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1823 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1882
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1883 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1912
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 179 bits (436), Expect = 8e-44
Identities = 88/191 (46%), Positives = 120/191 (62%), Gaps = 5/191 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 847 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 906
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
D V + D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 907 DCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMV 966
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK-- 1002
I D + N + A +R+ + + ++KR + +F++
Sbjct: 967 IGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1026
Query: 1003 -LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1027 FIRKQKILDEI 1037
Score = 101 bits (241), Expect = 3e-20
Identities = 87/287 (30%), Positives = 147/287 (51%), Gaps = 38/287 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 741 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 800
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 801 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 852
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F KD K
Sbjct: 853 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 912
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D E C
Sbjct: 913 ASDCQLPRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC---- 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 958 --LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 998
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALE 1238
CP C+ KF FL D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 723 CPP-CWYKFSNIFLIWDC-SPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME 777
Query: 1239 DVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLIN 1298
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 778 --HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
Query: 1299 FVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1358
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 836 L-----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 890
Query: 1359 LIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 891 FIFAVVGMQLFGKSYKDCV 909
Score = 80.6 bits (190), Expect = 5e-14
Identities = 49/187 (26%), Positives = 97/187 (51%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS +W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902
Query: 284 VLTQKCV 290
+ CV
Sbjct: 903 KSYKDCV 909
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1368
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1369 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1423
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1424 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1471
Score = 77.8 bits (183), Expect = 4e-13
Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
+ +E ++ RA ++++ T E+ E+ ++K C K + F +WDC WL+
Sbjct: 691 DFLEDPSQRQRA--MSIASILTNTVEELEES---RQKCPPCWYKFSNIFLIWDCSPYWLK 745
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 746 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGN 793
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1574
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1575 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1629
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1630 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1678
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1576 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1635
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1636 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1690
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1691 D-DMFNFETFGNSMICLFQI 1709
>AB098335-1|BAC45228.1| 1981|Homo sapiens Voltage-gated sodium channel
alpha 1 subunit protein.
Length = 1981
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1149 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1208
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1209 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1268
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1269 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1328
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1329 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1386
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1387 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1446
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1447 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1505
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1506 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1565
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1566 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1625
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1626 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1685
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1686 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1745
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1746 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1805
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1806 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1865
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1866 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1895
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 179 bits (436), Expect = 8e-44
Identities = 88/191 (46%), Positives = 120/191 (62%), Gaps = 5/191 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 830 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 889
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
D V + D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 890 DCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMV 949
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK-- 1002
I D + N + A +R+ + + ++KR + +F++
Sbjct: 950 IGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1009
Query: 1003 -LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1010 FIRKQKILDEI 1020
Score = 101 bits (241), Expect = 3e-20
Identities = 87/287 (30%), Positives = 147/287 (51%), Gaps = 38/287 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 724 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 783
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 784 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 835
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F KD K
Sbjct: 836 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 895
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D E C
Sbjct: 896 ASDCQLPRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC---- 940
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 941 --LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 981
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALE 1238
CP C+ KF FL D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 706 CPP-CWYKFSNIFLIWDC-SPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME 760
Query: 1239 DVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLIN 1298
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 761 --HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 818
Query: 1299 FVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1358
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 819 L-----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 873
Query: 1359 LIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 874 FIFAVVGMQLFGKSYKDCV 892
Score = 80.6 bits (190), Expect = 5e-14
Identities = 49/187 (26%), Positives = 97/187 (51%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS +W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 711 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 770
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 771 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 826
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 827 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 885
Query: 284 VLTQKCV 290
+ CV
Sbjct: 886 KSYKDCV 892
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1179 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1238
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1239 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1294
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1295 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1351
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1352 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1406
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1407 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1454
Score = 77.8 bits (183), Expect = 4e-13
Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
+ +E ++ RA ++++ T E+ E+ ++K C K + F +WDC WL+
Sbjct: 674 DFLEDPSQRQRA--MSIASILTNTVEELEES---RQKCPPCWYKFSNIFLIWDCSPYWLK 728
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 729 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGN 776
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1498 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1557
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1558 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1612
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1613 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1661
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1559 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1618
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1619 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1673
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1674 D-DMFNFETFGNSMICLFQI 1692
>AB093549-1|BAC21102.1| 1998|Homo sapiens Voltage-gated sodium channel
alpha1 subunit protein.
Length = 1998
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1166 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1225
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1226 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1285
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1286 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1345
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1346 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1403
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1404 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1463
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1464 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1522
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1523 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1582
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1583 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1702
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1703 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1762
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1763 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1822
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1823 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1882
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1883 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1912
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 179 bits (436), Expect = 8e-44
Identities = 88/191 (46%), Positives = 120/191 (62%), Gaps = 5/191 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 847 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 906
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
D V + D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 907 DCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMV 966
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK-- 1002
I D + N + A +R+ + + ++KR + +F++
Sbjct: 967 IGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1026
Query: 1003 -LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1027 FIRKQKILDEI 1037
Score = 101 bits (241), Expect = 3e-20
Identities = 87/287 (30%), Positives = 147/287 (51%), Gaps = 38/287 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 741 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 800
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 801 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 852
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F KD K
Sbjct: 853 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 912
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D E C
Sbjct: 913 ASDCQLPRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC---- 957
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 958 --LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 998
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALE 1238
CP C+ KF FL D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 723 CPP-CWYKFSNIFLIWDC-SPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME 777
Query: 1239 DVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLIN 1298
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 778 --HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
Query: 1299 FVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1358
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 836 L-----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 890
Query: 1359 LIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 891 FIFAVVGMQLFGKSYKDCV 909
Score = 80.6 bits (190), Expect = 5e-14
Identities = 49/187 (26%), Positives = 97/187 (51%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS +W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902
Query: 284 VLTQKCV 290
+ CV
Sbjct: 903 KSYKDCV 909
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1368
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1369 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1423
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1424 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1471
Score = 77.8 bits (183), Expect = 4e-13
Identities = 39/108 (36%), Positives = 63/108 (58%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
+ +E ++ RA ++++ T E+ E+ ++K C K + F +WDC WL+
Sbjct: 691 DFLEDPSQRQRA--MSIASILTNTVEELEES---RQKCPPCWYKFSNIFLIWDCSPYWLK 745
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 746 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGN 793
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1574
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1575 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1629
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1630 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1678
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1576 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1635
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1636 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1690
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1691 D-DMFNFETFGNSMICLFQI 1709
>AB093548-1|BAC21101.1| 2009|Homo sapiens voltage-gated sodium channel
alpha1 subunit protein.
Length = 2009
Score = 819 bits (2027), Expect = 0.0
Identities = 401/750 (53%), Positives = 540/750 (72%), Gaps = 19/750 (2%)
Query: 1177 PADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALA 1236
P C E C Q+F + + + W LR F+++E+ +FET ++ MILLSS ALA
Sbjct: 1177 PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALA 1236
Query: 1237 LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
ED+++ R ++ +L Y D++FT IF +EML+KW+A G+Q YFTNAWCWLDF+IV VSL
Sbjct: 1237 FEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSL 1296
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
++ A G + A K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCLI
Sbjct: 1297 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1356
Query: 1357 FWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACT--------LENYTWENSPMN 1408
FWLIF+IMGV LFAGK++ C+ N TT I D N T E W+N +N
Sbjct: 1357 FWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVN 1414
Query: 1409 FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXT 1468
FD+VG YL L QVATFKGW+ IM A+DSR V QP E ++YMYLY T
Sbjct: 1415 FDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1474
Query: 1469 LNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAI 1528
LNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +
Sbjct: 1475 LNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGM 1533
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
VF+ VT + FD+ IM+ I LNM+TM ++ QSE + +L +N++FIV+F+ EC+LK+
Sbjct: 1534 VFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLI 1593
Query: 1589 ALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1648
+LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGA
Sbjct: 1594 SLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1653
Query: 1649 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQS 1708
KGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK + G+DD++NF+TF S
Sbjct: 1654 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNS 1713
Query: 1709 MILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCGSATIGITYLLSYLVIS 1764
MI LFQ++TSAGWDG+L I+N + +CD GS G+CG+ ++GI + +SY++IS
Sbjct: 1714 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1773
Query: 1765 FLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLD 1824
FL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q++ +++LS F
Sbjct: 1774 FLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA 1833
Query: 1825 VLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDL 1880
LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1834 ALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERF 1893
Query: 1881 EVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + Y+P+++TL R++EE A +IQ
Sbjct: 1894 MASNPSKVSYQPITTTLKRKQEEVSAVIIQ 1923
Score = 431 bits (1063), Expect = e-120
Identities = 229/425 (53%), Positives = 289/425 (68%), Gaps = 45/425 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FTRESL K + +KK + GP+P++ LE G LP
Sbjct: 14 FNFFTRESLAAIERRIAEEKAKNPKPDKKDDDEN----------GPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL PFNP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW--------------G 300
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P + S G
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNG 302
Query: 301 NLTDE-----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYG 353
L +E +W+ + Q+ Y G D LCGNSS AGQC GY+C++ G NPNYG
Sbjct: 303 TLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYG 361
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAI 402
YTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA+
Sbjct: 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 421
Query: 403 VAMSY 407
VAM+Y
Sbjct: 422 VAMAY 426
Score = 179 bits (436), Expect = 8e-44
Identities = 88/191 (46%), Positives = 120/191 (62%), Gaps = 5/191 (2%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 858 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 917
Query: 887 DYVDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
D V + D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 918 DCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMV 977
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLK-- 1002
I D + N + A +R+ + + ++KR + +F++
Sbjct: 978 IGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1037
Query: 1003 -LLKNKLTNQI 1012
+ K K+ ++I
Sbjct: 1038 FIRKQKILDEI 1048
Score = 101 bits (241), Expect = 3e-20
Identities = 87/287 (30%), Positives = 147/287 (51%), Gaps = 38/287 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + +V +V D D+ I + I LN L M ++HY ++ F+ VL N++F IF
Sbjct: 752 PYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIF 811
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 812 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 863
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F KD K
Sbjct: 864 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 923
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D E C
Sbjct: 924 ASDCQLPRWHMNDFFHSFLIVFR---------VLCGEWIETMWDC--MEVAGQAMC---- 968
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+T + +VI L+V+N+++A++L ++S +++ TDDD +M
Sbjct: 969 --LTVFMMVMVIGNLVVLNLFLALLLSSFS--ADNL--AATDDDNEM 1009
Score = 80.6 bits (190), Expect = 5e-14
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%)
Query: 1181 CPEQCYQKFP--FLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALE 1238
CP C+ KF FL D SP+W ++ ++ + + + A+ I+L++L +A+E
Sbjct: 734 CPP-CWYKFSNIFLIWDC-SPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME 788
Query: 1239 DVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLIN 1298
H P ++L + +FT IF EM +K +A+ YF W D IV +SL+
Sbjct: 789 --HYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 846
Query: 1299 FVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFW 1358
G ++ +R+ R LR + + +++ + ++ ++ N+ LV I
Sbjct: 847 L-----GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 901
Query: 1359 LIFAIMGVQLFAGKYFKCV 1377
IFA++G+QLF Y CV
Sbjct: 902 FIFAVVGMQLFGKSYKDCV 920
Score = 80.6 bits (190), Expect = 5e-14
Identities = 49/187 (26%), Positives = 97/187 (51%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++FS +W P+ ++ V +++ P L I I++N + M M P +
Sbjct: 739 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 798
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++ L+ V +G+ ++
Sbjct: 799 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 854
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 855 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 913
Query: 284 VLTQKCV 290
+ CV
Sbjct: 914 KSYKDCV 920
Score = 80.2 bits (189), Expect = 7e-14
Identities = 72/292 (24%), Positives = 137/292 (46%), Gaps = 34/292 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+RR I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1207 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1266
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A G+ TY +AW WLDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1267 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1322
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G C+
Sbjct: 1323 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINT-- 1379
Query: 295 EDGSWGNLTDENWERFCQN--ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G ++ D N C E N + + ++ G GY+ L +
Sbjct: 1380 TTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF-----GYLSLLQVATFKGW 1434
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQ-LFFVVIIFLGSFYLVNLILAIV 403
D A S + Y E+LY L+FV+ I GSF+ +NL + ++
Sbjct: 1435 ----MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
Score = 78.6 bits (185), Expect = 2e-13
Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 697 KPSSDNPFIESSQQPNVVDMRDVMVLNEIIEQAGRQSRASELNVSVYYFPTAEDDEDGPT 756
KP++D+ + + V + +E ++ RA ++++ T E+ E+
Sbjct: 675 KPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRA--MSIASILTNTVEELEES-- 730
Query: 757 FKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDH 816
++K C K + F +WDC WL+ + V L+V DPFV+L IT+CIV+NTLFMA++H
Sbjct: 731 -RQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEH 789
Query: 817 HNMDKDMDKALKSGN 831
+ M + L GN
Sbjct: 790 YPMTDHFNNVLTVGN 804
Score = 75.4 bits (177), Expect = 2e-12
Identities = 51/165 (30%), Positives = 86/165 (52%), Gaps = 13/165 (7%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK +A GF + + W WLDF ++ + +V G + A
Sbjct: 161 FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 214
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
Query: 1374 FKCVDMNHTTLS-HEIIPDKNACTLENYTWENSPMNFDHVGKAYL 1417
KC+ T S E +KN N T N + F+ K+Y+
Sbjct: 275 NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETV-FEFDWKSYI 318
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/166 (27%), Positives = 81/166 (48%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 174 IARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
Score = 41.9 bits (94), Expect = 0.022
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 1526 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1585
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 1586 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1640
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 1641 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1689
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 1587 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 1646
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 1647 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 1701
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 1702 D-DMFNFETFGNSMICLFQI 1720
>AF117907-1|AAD30863.1| 1956|Homo sapiens tetrodotoxin-resistant
voltage-gated sodium channel protein.
Length = 1956
Score = 802 bits (1984), Expect = 0.0
Identities = 394/754 (52%), Positives = 534/754 (70%), Gaps = 21/754 (2%)
Query: 1175 DTPADCCPEQCYQKFPFLAGDDDSPFWQ-GWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
+ P DC E C + P D W GW +R ++++E+++FE+ +I MILLSS
Sbjct: 1109 EEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW-QVRKTCYRIVEHSWFESFIIFMILLSSG 1167
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
+LA ED +L +P ++ +L Y DR+FT IF EML+KW+A GF+KYFTNAWCWLDF+IV
Sbjct: 1168 SLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVN 1227
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
+SLI+ A + + K +RTLRALRPLRA+SR +GMRVVV+ALV AIPSI NVLLV
Sbjct: 1228 ISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLV 1287
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCV---DMNHTTLSHEIIPDKNACTLENYT----WENSP 1406
CLIFWLIF+IMGV LFAGK+++C+ D + + I+ +K+ C ++N T W N
Sbjct: 1288 CLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVK 1347
Query: 1407 MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXX 1466
+NFD+V YL L QVATFKGW+ IM A+DSREV QP E N+YMYLY
Sbjct: 1348 VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGF 1407
Query: 1467 XTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQ 1526
TLNLF+GVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q
Sbjct: 1408 FTLNLFVGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQ 1466
Query: 1527 AIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLK 1586
VF+IVT + FD+ IM+ I LNM+TM ++ QSE + +L +N F+ +F+ EC++K
Sbjct: 1467 GFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMK 1526
Query: 1587 IFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIE--KYFVSPTLLRVVRVAKVGRVLRL 1644
+FALR +YF WN+FDF+VV+ SI SL+ S I++ + + SPTL RV+R+A++GR+LRL
Sbjct: 1527 MFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRL 1586
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKT 1704
++ AKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGMS F HV+ + G+DD++NF+T
Sbjct: 1587 IRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQT 1646
Query: 1705 FVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLSY 1760
F SM+ LFQ++TSAGWDG+L I+N CD LP N G+ G+CGS +GI + +Y
Sbjct: 1647 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLP-NSNGTRGDCGSPAVGIIFFTTY 1705
Query: 1761 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLS 1820
++ISFLIV+NMYIAVILEN++ ATE+ E L++DD+DM+YE W++FDP+ +Q+I + LS
Sbjct: 1706 IIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALS 1765
Query: 1821 DFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDL 1880
DF D L PL+I KPN+ +I MD+P+ GD + C+DIL A TK+ G ++
Sbjct: 1766 DFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANM 1825
Query: 1881 E----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
E ++ YEP+++TL ++E+ A +IQ
Sbjct: 1826 EEKFMATNLSKSSYEPIATTLRWKQEDISATVIQ 1859
Score = 386 bits (949), Expect = e-106
Identities = 212/411 (51%), Positives = 256/411 (62%), Gaps = 26/411 (6%)
Query: 8 ISEEERSLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATL 67
I E + FR FT ESL +K EK R + + P+P L
Sbjct: 5 IGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEK-------PRPQLDL 57
Query: 68 EQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPF 127
+ LP + G P EL PLED+DPFY TF+V++KG+ I RFSAT ALW+ PF
Sbjct: 58 KACNQLP-KFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPF 116
Query: 128 NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMA 187
N IRR AI + VH FSLFI TILVNC+ M P E E +FT IYTFE+ +K++A
Sbjct: 117 NLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLP--EKIEYVFTVIYTFEALIKILA 174
Query: 188 RGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKT 247
RGF L FTYLRD WNWLDF VI LAYV IDL ++ LRTFRVLRALKTV+++PGLK
Sbjct: 175 RGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKV 234
Query: 248 IVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENW 307
IVGA+I SVK L DV ILT+F LSVFAL+GLQ++ G L KCVK D + T+ +
Sbjct: 235 IVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVK---NDMAVNETTNYSS 291
Query: 308 ERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSA 367
R N G D LCGN S +G C GY+CL+ NP++ YTSFD+F WAFLS
Sbjct: 292 HRKPDIYINKRGT-SDPLLCGNGSDSGHCPDGYICLK-TSDNPDFNYTSFDSFAWAFLSL 349
Query: 368 FRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
FRLMTQD WE LYQ +FFV++IFLGSFYLVNLILA+V M+Y
Sbjct: 350 FRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAY 400
Score = 159 bits (385), Expect = 1e-37
Identities = 89/218 (40%), Positives = 117/218 (53%), Gaps = 9/218 (4%)
Query: 790 LLVFDPFV----ELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTL 845
++ FDP+ + I CI+V + L K L+S LRVFKLAKSWPTL
Sbjct: 716 IIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAK--KGSLSVLRSFRLLRVFKLAKSWPTL 773
Query: 846 NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF--PDGDLPRWNFT 903
N LI I+G ++GALGNLT +L II+F+FA++G QL G+NY + P D PRW+
Sbjct: 774 NTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMH 833
Query: 904 DFMHSFMIVFRVLCGEWIESMWDCMLVGDVS-CIPFFLATVVIXXXXXXXXXXXXXXXXX 962
DF HSF+IVFR+LCGEWIE+MW CM VG S C+ FL +V+
Sbjct: 834 DFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSF 893
Query: 963 XXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D + N + A RI F K+ + F
Sbjct: 894 SADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF 931
Score = 97.5 bits (232), Expect = 4e-19
Identities = 55/165 (33%), Positives = 98/165 (59%), Gaps = 10/165 (6%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + I+F +VTD ++ I L I +N + M ++H+ S TF A+L N++F + F
Sbjct: 649 PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFF 708
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E + KI A Y+YF + WN+FD ++V S+L L + +K +S V+R ++
Sbjct: 709 TAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL---GVAKKGSLS-----VLRSFRL 760
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1683
RV +L K + TL+ + S+ AL N+ ++L +++F+FA+ G
Sbjct: 761 LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVG 805
Score = 87.0 bits (206), Expect = 6e-16
Identities = 69/291 (23%), Positives = 140/291 (48%), Gaps = 31/291 (10%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ I+ H F FII IL++ + + PTV E T+ +FT I+ FE
Sbjct: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ +++ ++ + ALRT R LR
Sbjct: 1201 MLLKWVAYGFK----KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALR 1256
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G +C+
Sbjct: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-WRCINYTD 1315
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGY 354
+ S L+ N + C+ + + G + GY+ L +
Sbjct: 1316 GEFSLVPLSIVNNKSDCKIQNS----TGSFFWVNVKVNFDNVAMGYLALLQVAT-----F 1366
Query: 355 TSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ +A + + + Q WE N+Y L+FV+ I G F+ +NL + ++
Sbjct: 1367 KGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417
Score = 80.2 bits (189), Expect = 7e-14
Identities = 59/181 (32%), Positives = 92/181 (50%), Gaps = 18/181 (9%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
F LI T + +V + L L + R L + + Y +FTVI+ E LIK
Sbjct: 116 FNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEY---VFTVIYTFEALIKI 172
Query: 1272 LALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAM 1327
LA GF Y + W WLDF ++ ++ + L G G+ RT R LR L+ +
Sbjct: 173 LARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGL------RTFRVLRALKTV 226
Query: 1328 SRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKCV--DM--NHT 1382
S + G++V+V AL+ ++ + +V ++ + +FA++G+QLF G KCV DM N T
Sbjct: 227 SVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNET 286
Query: 1383 T 1383
T
Sbjct: 287 T 287
Score = 78.2 bits (184), Expect = 3e-13
Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E +++ R RA + VS+ E +E ++K CL + +WDCC +W++
Sbjct: 599 EYLDEPFRAQRAMSV-VSIITSVLEELEES----EQKCPPCLTSLSQKYLIWDCCPMWVK 653
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ + LV DPF EL ITLCIVVNT+FMA++HH M + L+ GN
Sbjct: 654 LKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGN 701
Score = 73.7 bits (173), Expect = 6e-12
Identities = 46/159 (28%), Positives = 82/159 (51%), Gaps = 12/159 (7%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESA 182
++ + ++ P L I I+VN I M M +PT E+ ++FT +T E
Sbjct: 654 LKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMV 713
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGNLAALRTFRVLRALKTVAI 241
K++A P+ Y + WN D +++ ++ + +G+ G+L+ LR+FR+LR K
Sbjct: 714 FKIIA----FDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKS 769
Query: 242 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
P L T++ + SV L ++ I+ + VFAL+G Q+
Sbjct: 770 WPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQL 808
Score = 68.1 bits (159), Expect = 3e-10
Identities = 42/170 (24%), Positives = 80/170 (47%), Gaps = 7/170 (4%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W L+ F L+ + + E + I+++++ +A+E H P + +L + +FT+ F
Sbjct: 651 WVKLKTILFGLVTDPFAELTITLCIVVNTIFMAME--HHGMSPTFEAMLQIGNIVFTIFF 708
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
EM+ K +A YF W D IIV VSL+ A G + +R+ R LR
Sbjct: 709 TAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKG-----SLSVLRSFRLLRV 763
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
+ + ++ + ++ ++ N+ ++ I +FA++G QL Y
Sbjct: 764 FKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813
Score = 47.2 bits (107), Expect = 6e-04
Identities = 36/129 (27%), Positives = 64/129 (49%), Gaps = 15/129 (11%)
Query: 1571 LNMIFIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFV 1625
+ +F VI++ E L+KI A + Y +PWN DF V+ + + I+ +
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTA----IDLRGI 211
Query: 1626 SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMS 1685
S LR RV R L+ V G++ ++ AL S+ L ++ +L + +FA+ G+
Sbjct: 212 SG--LRTFRVL---RALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQ 266
Query: 1686 FFM-HVKDK 1693
F ++K+K
Sbjct: 267 LFKGNLKNK 275
Score = 47.2 bits (107), Expect = 6e-04
Identities = 38/170 (22%), Positives = 79/170 (46%), Gaps = 15/170 (8%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAV-- 183
P N + I+ F + I+ I +N I M++ T E I I F AV
Sbjct: 1461 PLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFT 1520
Query: 184 -KVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAA---------LRTFR 231
+ + + F L+ + Y + WN DF+V+ L+ ++ L +L + +R R
Sbjct: 1521 GECVMKMFALRQY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLAR 1579
Query: 232 VLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+ +
Sbjct: 1580 IGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSF 1629
Score = 36.3 bits (80), Expect = 1.1
Identities = 25/124 (20%), Positives = 61/124 (49%), Gaps = 7/124 (5%)
Query: 792 VFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISI 851
VFD V + ++ + + +L + + + ++ R+ +L ++ + L+
Sbjct: 1541 VFDFIVVVLSIASLIFSAILKSLQSY-FSPTLFRVIRLARIGRILRLIRAAKGIRTLLFA 1599
Query: 852 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMI 911
+ ++ AL N+ +L +++FI+++ GM F +V R+ G +NF F +S +
Sbjct: 1600 LMMSLPALFNIGLLLFLVMFIYSIFGMSSF-----PHV-RWEAGIDDMFNFQTFANSMLC 1653
Query: 912 VFRV 915
+F++
Sbjct: 1654 LFQI 1657
>AB208866-1|BAD92103.1| 1576|Homo sapiens voltage-gated sodium channel
type V alpha isoform b variant protein.
Length = 1576
Score = 784 bits (1939), Expect = 0.0
Identities = 395/755 (52%), Positives = 523/755 (69%), Gaps = 36/755 (4%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
+DV D P DC E C ++ P A D + W LR + ++E+++FET +I MIL
Sbjct: 737 QDVKD--PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMIL 794
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS ALA ED++L R ++ +L Y D++FT +F +EML+KW+A GF+KYFTNAWCWLDF
Sbjct: 795 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 854
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
+IV VSL++ VA G + K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI N
Sbjct: 855 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 914
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNH--TTLSHEIIPDKNACTLENYT----WE 1403
VLLVCLIFWLIF+IMGV LFAGK+ +C++ L++ I+ +K+ C N T W
Sbjct: 915 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 974
Query: 1404 NSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXX 1463
+NFD+VG YL L QV QP E N+YMY+Y
Sbjct: 975 KVKVNFDNVGAGYLALLQVYE------------------EQPQWEYNLYMYIYFVIFIIF 1016
Query: 1464 XXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1523
TLNLFIGVIIDNFN+QKKK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP
Sbjct: 1017 GSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1075
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
+ Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC
Sbjct: 1076 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1135
Query: 1584 LLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLR 1643
++K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KY SPTL RV+R+A++GR+LR
Sbjct: 1136 IVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYSFSPTLFRVIRLARIGRILR 1195
Query: 1644 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFK 1703
L++GAKGIRTLLFAL MSLPALFNI LLLFLVMFI++IFGM+ F +VK + G+DD++NF+
Sbjct: 1196 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQ 1255
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIIN--EEECD--LPDNERGSPGNCGSATIGITYLLS 1759
TF SM+ LFQ++TSAGWDG+L I+N CD LP N GS G+CGS +GI + +
Sbjct: 1256 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP-NSNGSRGDCGSPAVGILFFTT 1314
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
Y++ISFLIV+NMYIA+ILEN+S ATE+ E L++DD+DM+YEIW++FDP+ +Q+I Y L
Sbjct: 1315 YIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVL 1374
Query: 1820 SDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIE 1875
SDF D L PL+I KPN+ +I+MD+P+ GD + C+DIL A TK G I+
Sbjct: 1375 SDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQ 1434
Query: 1876 ETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+++TL R+ EE A +IQ
Sbjct: 1435 MEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1469
Score = 177 bits (431), Expect = 3e-43
Identities = 88/175 (50%), Positives = 109/175 (62%), Gaps = 2/175 (1%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL II+FIFAV+GMQLFGKNY
Sbjct: 386 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 445
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLV-GDVSCIPFFLATVVI 945
+ D G LPRW+ DF H+F+I+FR+LCGEWIE+MWDCM V G C+ FL +VI
Sbjct: 446 ELRDS-DSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVI 504
Query: 946 XXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADF 1000
P D++ N + A RI R + ++KR DF
Sbjct: 505 GNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDF 559
Score = 103 bits (247), Expect = 6e-21
Identities = 77/256 (30%), Positives = 135/256 (52%), Gaps = 31/256 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
+V D D+ I + I LN L M L+HY + F +L N++F IF++E KI AL
Sbjct: 292 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALD 351
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF + WN+FD ++V+ S++ L LS + + L V+R ++ RV +L K
Sbjct: 352 PYYYFQQGWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPT 403
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDK-GGLDDVYNFKTF 1705
+ TL+ + S+ AL N+ L+L +++FIFA+ GM F ++D GL ++ F
Sbjct: 404 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDF 463
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++F+ +L G E D + G + + +LL +VI
Sbjct: 464 FHAFLIIFR---------ILCGEWIETMWDCMEVS-------GQSLCLLVFLL-VMVIGN 506
Query: 1766 LIVINMYIAVILENYS 1781
L+V+N+++A++L ++S
Sbjct: 507 LVVLNLFLALLLSSFS 522
Score = 80.6 bits (190), Expect = 5e-14
Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)
Query: 727 EQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQK 786
E+ G + RA VSV E +E + K C + + +W+CC LW+ ++
Sbjct: 233 EEPGARQRALSA-VSVLTSALEELEES----RHKCPPCWNRLAQRYLIWECCPLWMSIKQ 287
Query: 787 YVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
V L+V DPF +L IT+CIV+NTLFMAL+H+NM + ++ L+ GN
Sbjct: 288 GVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 332
Score = 78.6 bits (185), Expect = 2e-13
Identities = 71/292 (24%), Positives = 137/292 (46%), Gaps = 52/292 (17%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTV----ESTEVIFTGIYTFE 180
+R+ +I+ H F FII IL++ + + T+ E + +FT ++ E
Sbjct: 772 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 831
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-----TMGI-DLGNLAALRTFRVLR 234
+K +A GF Y +AW WLDF+++ ++ V T+G ++G + +LRT R LR
Sbjct: 832 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 887
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++
Sbjct: 888 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA------------ 935
Query: 295 EDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGN-SSGAGQCEPGYVCLQGFGPNPNYG 353
G +G C N+T GD PL + QCE + + +
Sbjct: 936 --GKFGR---------CINQTE-----GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN 979
Query: 354 YTSFDTFGWAFLSAFRLMTQDYWE-NLYQ-LFFVVIIFLGSFYLVNLILAIV 403
+ + A L + Q WE NLY ++FV+ I GSF+ +NL + ++
Sbjct: 980 FDNVGAGYLALLQVYE--EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1029
Score = 77.4 bits (182), Expect = 5e-13
Identities = 48/177 (27%), Positives = 93/177 (52%), Gaps = 13/177 (7%)
Query: 114 RFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----TTPTVES 168
R + +W P + I++ +++ P L I I++N + M + T+ E
Sbjct: 268 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEM 327
Query: 169 TEV---IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID-LGNL 224
+V +FTGI+T E K++A L P+ Y + WN D +++ L+ + +G+ + NL
Sbjct: 328 LQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNL 383
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ LR+FR+LR K P L T++ + SV L ++ ++ + +FA++G+Q++
Sbjct: 384 SVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 440
Score = 70.1 bits (164), Expect = 7e-11
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 1213 KLIENTYFETAVITM-ILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
KL+ F ITM I+L++L +ALE ++ +++L + +FT IF EM K
Sbjct: 290 KLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNLVFTGIFTAEMTFKI 347
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQ 1331
+AL YF W D IIV++SL+ G + +R+ R LR +
Sbjct: 348 IALDPYYYFQQGWNIFDSIIVILSLMEL-----GLSRMSNLSVLRSFRLLRVFKLAKSWP 402
Query: 1332 GMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
+ ++ + ++ ++ N+ LV I IFA++G+QLF Y + D
Sbjct: 403 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD 449
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/169 (23%), Positives = 82/169 (48%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPT----VESTEVIFTGIYT 178
P N + I+ F + I+ I +N + M++ T +P + ++F I+T
Sbjct: 1073 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1132
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN--------LAALRT 229
E VK+ A L+ + Y ++WN DFVV+ L+ V T+ D+ +R
Sbjct: 1133 GECIVKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYSFSPTLFRVIRL 1187
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++++ G+
Sbjct: 1188 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1236
Score = 37.5 bits (83), Expect = 0.48
Identities = 24/115 (20%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 801 ITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALG 860
+ L IV L + ++ + + ++ R+ +L + + L+ + ++ AL
Sbjct: 1159 VILSIVGTVLSDIIQKYSFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALF 1218
Query: 861 NLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
N+ +L +++FI+++ GM F YV + D +NF F +S + +F++
Sbjct: 1219 NIGLLLFLVMFIYSIFGMANFA--YVKWEAGIDD----MFNFQTFANSMLCLFQI 1267
>AJ417790-1|CAD10507.1| 1791|Homo sapiens voltage-gated sodium channel
protein.
Length = 1791
Score = 756 bits (1870), Expect = 0.0
Identities = 372/748 (49%), Positives = 518/748 (69%), Gaps = 21/748 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E V P C P+ FP + D P W W LR ++++++++FE+ +I +IL
Sbjct: 1008 EMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVIL 1067
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS AL EDVHL ++P +Q++L D IFT IF +EM++KW+A GF KYFT+AWC LDF
Sbjct: 1068 LSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDF 1127
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
IIV+VS+ + + K+ RTLRALRPLRA+S+ +GM+VVVNAL+ AIP+I N
Sbjct: 1128 IIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILN 1180
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNF 1409
VLLVCLIFWL+F I+GV F+GK+ KC++ + +++ II +K+ C N++W N +NF
Sbjct: 1181 VLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNF 1240
Query: 1410 DHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTL 1469
D+VG AYL L QVATFKGW+ I+ A+DS E +QP E+N Y+Y TL
Sbjct: 1241 DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTL 1300
Query: 1470 NLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIV 1529
NLFIGVIIDNFN+Q+KK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +V
Sbjct: 1301 NLFIGVIIDNFNQQQKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
Query: 1530 FEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA 1589
F+IVT + FD+II+ I LNM++M + Y Q + ++LD+LN +F+VIF+ ECL+KIFA
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
Query: 1590 LRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFV--SPTLLRVVRVAKVGRVLRLVKG 1647
LR +YF WNLFD VVV+ SI+S ++S + + + PTL R+VR+A++GR+LRLV+
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQ 1707
A+GIRTLLFAL MSLP+LFNI LLLFL+MFI+AI GM++F V + G+DD++NFKTF
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
Query: 1708 SMILLFQMSTSAGWDGVLDGII-NEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
SM+ LFQ+STSAGWD +L ++ ++E C+ S NC I +Y +SY++ISFL
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRSKESCN------SSSENCHLPGIATSYFVSYIIISFL 1593
Query: 1767 IVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVL 1826
IV+NMYIAVILEN++ ATE+ ++ L +DD+D++YE+W++FDP+ +Q+I+Y LSDF D L
Sbjct: 1594 IVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADAL 1653
Query: 1827 EPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLE----V 1882
PL++ KPNKY+ + MD+P+ D + C+DIL A T +E
Sbjct: 1654 PEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFME 1713
Query: 1883 GRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+ +T R+ EE A +IQ
Sbjct: 1714 ANPLKKLYEPIVTTTKRKEEERGAAIIQ 1741
Score = 326 bits (800), Expect = 6e-88
Identities = 185/418 (44%), Positives = 252/418 (60%), Gaps = 41/418 (9%)
Query: 8 ISEEERSLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATL 67
I +ER+ FRPFT +SL K+K K GEV P+P L
Sbjct: 9 IFPDERN-FRPFTSDSLAAIEKRIAIQKEKKKS---KDQTGEVPQ--------PRPQLDL 56
Query: 68 EQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPF 127
+ LP ++ G P EL PLED+DPFY N TF+V+++ + I+RFSA +AL+I PF
Sbjct: 57 KASRKLP-KLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPF 115
Query: 128 NPIRRVAIYILVHPLFSLFIITTILVNCILMIM-----PTTPTVESTEVIFTGIYTFESA 182
N IR +AI + VH LFS+FII T+++NC+ M + + E +FTGIY FE+
Sbjct: 116 NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEAL 175
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAALRTFRVLRALKTVA 240
+K++ARGFIL F++LRD WNWLD +VI +A V+ GI + L LRTFRV RALK ++
Sbjct: 176 IKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAIS 234
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
+V LK IVGA++ SVK L +VIILT F LS+FAL+G Q++MG L KC+ ++ S
Sbjct: 235 VVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS-- 292
Query: 301 NLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTF 360
E ++ + + N ++ +CG G C Y C + NP+Y YT+FD F
Sbjct: 293 --NPEAYDHCFEKKEN----SPEFKMCGIWMGNSACSIQYEC-KHTKINPDYNYTNFDNF 345
Query: 361 GWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
GW+FL+ FRLMTQD WE LYQ FF+V+IFLGSFYL+NL LA+V M+Y
Sbjct: 346 GWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAY 403
Score = 134 bits (324), Expect = 3e-30
Identities = 68/129 (52%), Positives = 88/129 (68%), Gaps = 10/129 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALG+LT VL I+IFIF+V+GMQLFG+++
Sbjct: 669 LRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFN 728
Query: 887 DYVDR---FPDGD----LPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVS---CI 936
P G L W+ DF HSF++VFR+LCGEWIE+MW+CM + S C+
Sbjct: 729 SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCV 788
Query: 937 PFFLATVVI 945
F+ VI
Sbjct: 789 IVFILITVI 797
Score = 91.9 bits (218), Expect = 2e-17
Identities = 74/266 (27%), Positives = 136/266 (51%), Gaps = 16/266 (6%)
Query: 1521 PRWR-PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P+W + ++ ++T ++ I + I +N + + ++H++ +F +L+ N++F IF
Sbjct: 561 PQWLCVKKVLRTVMTGPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
+E LKI AL YHYF WN+FD +V + S V++ +++K S LR RV
Sbjct: 621 IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKR--SWPFLRSFRVL-- 675
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDD 1698
RV +L K + TL+ + S+ AL ++ ++L +V+FIF++ GM F +
Sbjct: 676 -RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPK 734
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC-DLPDN--ERGSPGNCGSATIGIT 1755
+ N S + + M W L ++ C + +N E N S+ I
Sbjct: 735 LCNPTGPTVSCLRHWHMGDF--WHSFL--VVFRILCGEWIENMWECMQEANASSSLCVIV 790
Query: 1756 YLLSYLVISFLIVINMYIAVILENYS 1781
++L VI L+V+N++IA++L ++S
Sbjct: 791 FIL-ITVIGKLVVLNLFIALLLNSFS 815
Score = 81.4 bits (192), Expect = 3e-14
Identities = 66/266 (24%), Positives = 126/266 (47%), Gaps = 46/266 (17%)
Query: 1258 IFTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFK 1313
+FT I+ E LIK LA GF + + W WLD I++ +++++++ + I+
Sbjct: 165 VFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLLP 220
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
+RT R R L+A+S + ++V+V AL++++ + NV+++ IFA++G QLF G
Sbjct: 221 -LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSL 279
Query: 1374 -FKCVDMNHTTLSH-----------EIIPD---------KNACTLE---NYTWEN---SP 1406
KC+ + +S+ E P+ +AC+++ +T N +
Sbjct: 280 NLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
Query: 1407 MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXX 1466
NFD+ G ++L +F++ T W ++ +Q +R T +Y +
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSF 389
Query: 1467 XTLNLFIGVIIDNFNEQKKKAGGSLE 1492
+NL + V+ + EQ K +E
Sbjct: 390 YLINLTLAVVTMAYEEQNKNVAAEIE 415
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/285 (24%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTVES----TEVIFTGIYTFE 180
+R+ I+ H F FII IL++ +I + P ++ T++IFT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
+K +A GF Y AW LDF+++ ++ T+ I+L L + RT R LR L+ ++
Sbjct: 1105 MVLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTL-INLMELKSFRTLRALRPLRALS 1159
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
G+K +V A+I ++ + +V+++ + VF ++G+ + G KC+ ++
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218
Query: 301 NLTDENWERFCQN-ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDT 359
+T+++ C++ +W + ++ GN+ Y+ L + D
Sbjct: 1219 IITNKSQ---CESGNFSWINQKVNFDNVGNA---------YLALLQVATFKGW----MDI 1262
Query: 360 FGWAFLSAFRLMTQDYWEN-LYQLFFVVIIFLGSFYLVNLILAIV 403
A S + ++ N L ++FVV I GSF+ +NL + ++
Sbjct: 1263 IYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
Score = 71.7 bits (168), Expect = 2e-11
Identities = 42/145 (28%), Positives = 72/145 (49%), Gaps = 8/145 (5%)
Query: 691 EAGKVLKPSSDNPFIESSQQPNVVD----MRDVMVLNEIIEQAGRQSRASELNVSVYYFP 746
E+GK P SD+ + ++P +++ + + L+ E R L+
Sbjct: 473 ESGKDQPPGSDSDE-DCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTI 531
Query: 747 TAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIV 806
T ++ E +E L C + VW+CC WL +K + ++ PF EL IT+CI+
Sbjct: 532 TMKEQEKS---QEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTGPFTELAITICII 588
Query: 807 VNTLFMALDHHNMDKDMDKALKSGN 831
+NT+F+A++HH M+ +K L GN
Sbjct: 589 INTVFLAMEHHKMEASFEKMLNIGN 613
Score = 63.3 bits (147), Expect = 8e-09
Identities = 41/162 (25%), Positives = 79/162 (48%), Gaps = 14/162 (8%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTFESA 182
+++V ++ P L I I++N + + M S E ++FT I+ E
Sbjct: 566 VKKVLRTVMTGPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMG---IDLGNLAALRTFRVLRALKTV 239
+K++A L P+ Y R WN D +V L++ + + + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
P L T++ + SV L + ++ + + +F+++G+Q++
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 60.5 bits (140), Expect = 6e-08
Identities = 40/155 (25%), Positives = 78/155 (50%), Gaps = 5/155 (3%)
Query: 1219 YFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQK 1278
+ E A+ I+++++ LA+E H + +L + +FT IF EM +K +AL
Sbjct: 578 FTELAITICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYH 635
Query: 1279 YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1338
YF W D I+ ++S + + + ++ R LR + ++ + + ++
Sbjct: 636 YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIG 695
Query: 1339 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
V A+ S+ V+LV +IF IF+++G+QLF +
Sbjct: 696 NSVGALGSL-TVVLVIVIF--IFSVVGMQLFGRSF 727
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/168 (23%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
+++ + F M I+ + +N + M + S + + D +F I+ E L+
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALI 176
Query: 1586 KIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
KI A + + +PWN D +V+ +I+S + I+ L +R +V R
Sbjct: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRTFRVFR 228
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
L+ + ++ ++ AL S+ L N+ +L F + IFA+ G FM
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFM 276
Score = 50.8 bits (116), Expect = 5e-05
Identities = 43/177 (24%), Positives = 85/177 (48%), Gaps = 23/177 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + I+ +F + II+ I++N I M+ + ++ +F I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN----------LAAL 227
E +K+ F L+ + Y + WN D VV+ L+ V TM L N +
Sbjct: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
R R+ R L+ V G++T++ A++ S+ +L ++ +L + ++A++G+ + V
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKV 1522
Score = 41.1 bits (92), Expect = 0.039
Identities = 34/145 (23%), Positives = 70/145 (48%), Gaps = 9/145 (6%)
Query: 792 VFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISI 851
+FD V L + +++TL +H + + ++ R+ +L ++ + L+
Sbjct: 1431 LFDCVVVLLSIVSTMISTLENQ-EHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFA 1489
Query: 852 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK-NYVDYVDRFPDGDLPRWNFTDFMHSFM 910
+ ++ +L N+ +L +I+FI+A++GM F K N +D D+ +NF F S +
Sbjct: 1490 LMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGID-----DI--FNFKTFASSML 1542
Query: 911 IVFRVLCGEWIESMWDCMLVGDVSC 935
+F++ +S+ ML SC
Sbjct: 1543 CLFQISTSAGWDSLLSPMLRSKESC 1567
>AF188679-1|AAF17480.1| 1791|Homo sapiens voltage-gated sodium channel
type XI alpha subunit protein.
Length = 1791
Score = 756 bits (1870), Expect = 0.0
Identities = 372/748 (49%), Positives = 518/748 (69%), Gaps = 21/748 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E V P C P+ FP + D P W W LR ++++++++FE+ +I +IL
Sbjct: 1008 EMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVIL 1067
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS AL EDVHL ++P +Q++L D IFT IF +EM++KW+A GF KYFT+AWC LDF
Sbjct: 1068 LSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDF 1127
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
IIV+VS+ + + K+ RTLRALRPLRA+S+ +GM+VVVNAL+ AIP+I N
Sbjct: 1128 IIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILN 1180
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNF 1409
VLLVCLIFWL+F I+GV F+GK+ KC++ + +++ II +K+ C N++W N +NF
Sbjct: 1181 VLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNF 1240
Query: 1410 DHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTL 1469
D+VG AYL L QVATFKGW+ I+ A+DS E +QP E+N Y+Y TL
Sbjct: 1241 DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTL 1300
Query: 1470 NLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIV 1529
NLFIGVIIDNFN+Q+KK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +V
Sbjct: 1301 NLFIGVIIDNFNQQQKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
Query: 1530 FEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA 1589
F+IVT + FD+II+ I LNM++M + Y Q + ++LD+LN +F+VIF+ ECL+KIFA
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
Query: 1590 LRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFV--SPTLLRVVRVAKVGRVLRLVKG 1647
LR +YF WNLFD VVV+ SI+S ++S + + + PTL R+VR+A++GR+LRLV+
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQ 1707
A+GIRTLLFAL MSLP+LFNI LLLFL+MFI+AI GM++F V + G+DD++NFKTF
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
Query: 1708 SMILLFQMSTSAGWDGVLDGII-NEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
SM+ LFQ+STSAGWD +L ++ ++E C+ S NC I +Y +SY++ISFL
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRSKESCN------SSSENCHLPGIATSYFVSYIIISFL 1593
Query: 1767 IVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVL 1826
IV+NMYIAVILEN++ ATE+ ++ L +DD+D++YE+W++FDP+ +Q+I+Y LSDF D L
Sbjct: 1594 IVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADAL 1653
Query: 1827 EPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLE----V 1882
PL++ KPNKY+ + MD+P+ D + C+DIL A T +E
Sbjct: 1654 PEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFME 1713
Query: 1883 GRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+ +T R+ EE A +IQ
Sbjct: 1714 ANPLKKLYEPIVTTTKRKEEERGAAIIQ 1741
Score = 326 bits (800), Expect = 6e-88
Identities = 185/418 (44%), Positives = 252/418 (60%), Gaps = 41/418 (9%)
Query: 8 ISEEERSLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATL 67
I +ER+ FRPFT +SL K+K K GEV P+P L
Sbjct: 9 IFPDERN-FRPFTSDSLAAIEKRIAIQKEKKKS---KDQTGEVPQ--------PRPQLDL 56
Query: 68 EQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPF 127
+ LP ++ G P EL PLED+DPFY N TF+V+++ + I+RFSA +AL+I PF
Sbjct: 57 KASRKLP-KLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPF 115
Query: 128 NPIRRVAIYILVHPLFSLFIITTILVNCILMIM-----PTTPTVESTEVIFTGIYTFESA 182
N IR +AI + VH LFS+FII T+++NC+ M + + E +FTGIY FE+
Sbjct: 116 NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEAL 175
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAALRTFRVLRALKTVA 240
+K++ARGFIL F++LRD WNWLD +VI +A V+ GI + L LRTFRV RALK ++
Sbjct: 176 IKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAIS 234
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
+V LK IVGA++ SVK L +VIILT F LS+FAL+G Q++MG L KC+ ++ S
Sbjct: 235 VVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS-- 292
Query: 301 NLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTF 360
E ++ + + N ++ +CG G C Y C + NP+Y YT+FD F
Sbjct: 293 --NPEAYDHCFEKKEN----SPEFKMCGIWMGNSACSIQYEC-KHTKINPDYNYTNFDNF 345
Query: 361 GWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
GW+FL+ FRLMTQD WE LYQ FF+V+IFLGSFYL+NL LA+V M+Y
Sbjct: 346 GWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAY 403
Score = 134 bits (324), Expect = 3e-30
Identities = 68/129 (52%), Positives = 88/129 (68%), Gaps = 10/129 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALG+LT VL I+IFIF+V+GMQLFG+++
Sbjct: 669 LRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFN 728
Query: 887 DYVDR---FPDGD----LPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVS---CI 936
P G L W+ DF HSF++VFR+LCGEWIE+MW+CM + S C+
Sbjct: 729 SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCV 788
Query: 937 PFFLATVVI 945
F+ VI
Sbjct: 789 IVFILITVI 797
Score = 94.7 bits (225), Expect = 3e-18
Identities = 75/266 (28%), Positives = 137/266 (51%), Gaps = 16/266 (6%)
Query: 1521 PRWR-PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P+W + ++ ++TD ++ I + I +N + + ++H++ +F +L+ N++F IF
Sbjct: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
+E LKI AL YHYF WN+FD +V + S V++ +++K S LR RV
Sbjct: 621 IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKR--SWPFLRSFRVL-- 675
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDD 1698
RV +L K + TL+ + S+ AL ++ ++L +V+FIF++ GM F +
Sbjct: 676 -RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPK 734
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC-DLPDN--ERGSPGNCGSATIGIT 1755
+ N S + + M W L ++ C + +N E N S+ I
Sbjct: 735 LCNPTGPTVSCLRHWHMGDF--WHSFL--VVFRILCGEWIENMWECMQEANASSSLCVIV 790
Query: 1756 YLLSYLVISFLIVINMYIAVILENYS 1781
++L VI L+V+N++IA++L ++S
Sbjct: 791 FIL-ITVIGKLVVLNLFIALLLNSFS 815
Score = 81.4 bits (192), Expect = 3e-14
Identities = 66/266 (24%), Positives = 126/266 (47%), Gaps = 46/266 (17%)
Query: 1258 IFTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFK 1313
+FT I+ E LIK LA GF + + W WLD I++ +++++++ + I+
Sbjct: 165 VFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLLP 220
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
+RT R R L+A+S + ++V+V AL++++ + NV+++ IFA++G QLF G
Sbjct: 221 -LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSL 279
Query: 1374 -FKCVDMNHTTLSH-----------EIIPD---------KNACTLE---NYTWEN---SP 1406
KC+ + +S+ E P+ +AC+++ +T N +
Sbjct: 280 NLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
Query: 1407 MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXX 1466
NFD+ G ++L +F++ T W ++ +Q +R T +Y +
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSF 389
Query: 1467 XTLNLFIGVIIDNFNEQKKKAGGSLE 1492
+NL + V+ + EQ K +E
Sbjct: 390 YLINLTLAVVTMAYEEQNKNVAAEIE 415
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/285 (24%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTVES----TEVIFTGIYTFE 180
+R+ I+ H F FII IL++ +I + P ++ T++IFT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
+K +A GF Y AW LDF+++ ++ T+ I+L L + RT R LR L+ ++
Sbjct: 1105 MVLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTL-INLMELKSFRTLRALRPLRALS 1159
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
G+K +V A+I ++ + +V+++ + VF ++G+ + G KC+ ++
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218
Query: 301 NLTDENWERFCQN-ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDT 359
+T+++ C++ +W + ++ GN+ Y+ L + D
Sbjct: 1219 IITNKSQ---CESGNFSWINQKVNFDNVGNA---------YLALLQVATFKGW----MDI 1262
Query: 360 FGWAFLSAFRLMTQDYWEN-LYQLFFVVIIFLGSFYLVNLILAIV 403
A S + ++ N L ++FVV I GSF+ +NL + ++
Sbjct: 1263 IYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
Score = 74.5 bits (175), Expect = 3e-12
Identities = 43/145 (29%), Positives = 73/145 (50%), Gaps = 8/145 (5%)
Query: 691 EAGKVLKPSSDNPFIESSQQPNVVD----MRDVMVLNEIIEQAGRQSRASELNVSVYYFP 746
E+GK P SD+ + ++P +++ + + L+ E R L+
Sbjct: 473 ESGKDQPPGSDSDE-DCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTI 531
Query: 747 TAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIV 806
T ++ E +E L C + VW+CC WL +K + ++ DPF EL IT+CI+
Sbjct: 532 TMKEQEKS---QEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICII 588
Query: 807 VNTLFMALDHHNMDKDMDKALKSGN 831
+NT+F+A++HH M+ +K L GN
Sbjct: 589 INTVFLAMEHHKMEASFEKMLNIGN 613
Score = 63.7 bits (148), Expect = 6e-09
Identities = 41/162 (25%), Positives = 79/162 (48%), Gaps = 14/162 (8%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTFESA 182
+++V ++ P L I I++N + + M S E ++FT I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMG---IDLGNLAALRTFRVLRALKTV 239
+K++A L P+ Y R WN D +V L++ + + + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
P L T++ + SV L + ++ + + +F+++G+Q++
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 60.9 bits (141), Expect = 5e-08
Identities = 40/160 (25%), Positives = 81/160 (50%), Gaps = 5/160 (3%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + E A+ I+++++ LA+E H + +L + +FT IF EM +K +A
Sbjct: 573 VMTDPFTELAITICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 630
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
L YF W D I+ ++S + + + ++ R LR + ++ + +
Sbjct: 631 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTL 690
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
++ V A+ S+ V+LV +IF IF+++G+QLF +
Sbjct: 691 IKIIGNSVGALGSL-TVVLVIVIF--IFSVVGMQLFGRSF 727
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/168 (23%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
+++ + F M I+ + +N + M + S + + D +F I+ E L+
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALI 176
Query: 1586 KIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
KI A + + +PWN D +V+ +I+S + I+ L +R +V R
Sbjct: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRTFRVFR 228
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
L+ + ++ ++ AL S+ L N+ +L F + IFA+ G FM
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFM 276
Score = 50.8 bits (116), Expect = 5e-05
Identities = 43/177 (24%), Positives = 85/177 (48%), Gaps = 23/177 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + I+ +F + II+ I++N I M+ + ++ +F I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN----------LAAL 227
E +K+ F L+ + Y + WN D VV+ L+ V TM L N +
Sbjct: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
R R+ R L+ V G++T++ A++ S+ +L ++ +L + ++A++G+ + V
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKV 1522
Score = 41.1 bits (92), Expect = 0.039
Identities = 34/145 (23%), Positives = 70/145 (48%), Gaps = 9/145 (6%)
Query: 792 VFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISI 851
+FD V L + +++TL +H + + ++ R+ +L ++ + L+
Sbjct: 1431 LFDCVVVLLSIVSTMISTLENQ-EHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFA 1489
Query: 852 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK-NYVDYVDRFPDGDLPRWNFTDFMHSFM 910
+ ++ +L N+ +L +I+FI+A++GM F K N +D D+ +NF F S +
Sbjct: 1490 LMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGID-----DI--FNFKTFASSML 1542
Query: 911 IVFRVLCGEWIESMWDCMLVGDVSC 935
+F++ +S+ ML SC
Sbjct: 1543 CLFQISTSAGWDSLLSPMLRSKESC 1567
>AF109737-1|AAF24976.1| 1791|Homo sapiens voltage-gated sodium channel
alpha subunit SCN12A protein.
Length = 1791
Score = 756 bits (1870), Expect = 0.0
Identities = 372/748 (49%), Positives = 518/748 (69%), Gaps = 21/748 (2%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E V P C P+ FP + D P W W LR ++++++++FE+ +I +IL
Sbjct: 1008 EMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVIL 1067
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS AL EDVHL ++P +Q++L D IFT IF +EM++KW+A GF KYFT+AWC LDF
Sbjct: 1068 LSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDF 1127
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
IIV+VS+ + + K+ RTLRALRPLRA+S+ +GM+VVVNAL+ AIP+I N
Sbjct: 1128 IIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILN 1180
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNF 1409
VLLVCLIFWL+F I+GV F+GK+ KC++ + +++ II +K+ C N++W N +NF
Sbjct: 1181 VLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNF 1240
Query: 1410 DHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTL 1469
D+VG AYL L QVATFKGW+ I+ A+DS E +QP E+N Y+Y TL
Sbjct: 1241 DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTL 1300
Query: 1470 NLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIV 1529
NLFIGVIIDNFN+Q+KK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +V
Sbjct: 1301 NLFIGVIIDNFNQQQKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
Query: 1530 FEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA 1589
F+IVT + FD+II+ I LNM++M + Y Q + ++LD+LN +F+VIF+ ECL+KIFA
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
Query: 1590 LRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFV--SPTLLRVVRVAKVGRVLRLVKG 1647
LR +YF WNLFD VVV+ SI+S ++S + + + PTL R+VR+A++GR+LRLV+
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQ 1707
A+GIRTLLFAL MSLP+LFNI LLLFL+MFI+AI GM++F V + G+DD++NFKTF
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
Query: 1708 SMILLFQMSTSAGWDGVLDGII-NEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
SM+ LFQ+STSAGWD +L ++ ++E C+ S NC I +Y +SY++ISFL
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRSKESCN------SSSENCHLPGIATSYFVSYIIISFL 1593
Query: 1767 IVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVL 1826
IV+NMYIAVILEN++ ATE+ ++ L +DD+D++YE+W++FDP+ +Q+I+Y LSDF D L
Sbjct: 1594 IVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADAL 1653
Query: 1827 EPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLE----V 1882
PL++ KPNKY+ + MD+P+ D + C+DIL A T +E
Sbjct: 1654 PEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFME 1713
Query: 1883 GRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
P + YEP+ +T R+ EE A +IQ
Sbjct: 1714 ANPLKKLYEPIVTTTKRKEEERGAAIIQ 1741
Score = 326 bits (800), Expect = 6e-88
Identities = 185/418 (44%), Positives = 252/418 (60%), Gaps = 41/418 (9%)
Query: 8 ISEEERSLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATL 67
I +ER+ FRPFT +SL K+K K GEV P+P L
Sbjct: 9 IFPDERN-FRPFTSDSLAAIEKRIAIQKEKKKS---KDQTGEVPQ--------PRPQLDL 56
Query: 68 EQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPF 127
+ LP ++ G P EL PLED+DPFY N TF+V+++ + I+RFSA +AL+I PF
Sbjct: 57 KASRKLP-KLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPF 115
Query: 128 NPIRRVAIYILVHPLFSLFIITTILVNCILMIM-----PTTPTVESTEVIFTGIYTFESA 182
N IR +AI + VH LFS+FII T+++NC+ M + + E +FTGIY FE+
Sbjct: 116 NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEAL 175
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAALRTFRVLRALKTVA 240
+K++ARGFIL F++LRD WNWLD +VI +A V+ GI + L LRTFRV RALK ++
Sbjct: 176 IKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAIS 234
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
+V LK IVGA++ SVK L +VIILT F LS+FAL+G Q++MG L KC+ ++ S
Sbjct: 235 VVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS-- 292
Query: 301 NLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTF 360
E ++ + + N ++ +CG G C Y C + NP+Y YT+FD F
Sbjct: 293 --NPEAYDHCFEKKEN----SPEFKMCGIWMGNSACSIQYEC-KHTKINPDYNYTNFDNF 345
Query: 361 GWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
GW+FL+ FRLMTQD WE LYQ FF+V+IFLGSFYL+NL LA+V M+Y
Sbjct: 346 GWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAY 403
Score = 136 bits (329), Expect = 7e-31
Identities = 69/129 (53%), Positives = 88/129 (68%), Gaps = 10/129 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL I+IFIF+V+GMQLFG+++
Sbjct: 669 LRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSFN 728
Query: 887 DYVDR---FPDGD----LPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVS---CI 936
P G L W+ DF HSF++VFR+LCGEWIE+MW+CM + S C+
Sbjct: 729 SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCV 788
Query: 937 PFFLATVVI 945
F+ VI
Sbjct: 789 IVFILITVI 797
Score = 96.7 bits (230), Expect = 7e-19
Identities = 76/266 (28%), Positives = 137/266 (51%), Gaps = 16/266 (6%)
Query: 1521 PRWR-PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P+W + ++ ++TD ++ I + I +N + + ++H++ +F +L+ N++F IF
Sbjct: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
+E LKI AL YHYF WN+FD +V + S V++ +++K S LR RV
Sbjct: 621 IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKR--SWPFLRSFRVL-- 675
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDD 1698
RV +L K + TL+ + S+ AL N+ ++L +V+FIF++ GM F +
Sbjct: 676 -RVFKLAKSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPK 734
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC-DLPDN--ERGSPGNCGSATIGIT 1755
+ N S + + M W L ++ C + +N E N S+ I
Sbjct: 735 LCNPTGPTVSCLRHWHMGDF--WHSFL--VVFRILCGEWIENMWECMQEANASSSLCVIV 790
Query: 1756 YLLSYLVISFLIVINMYIAVILENYS 1781
++L VI L+V+N++IA++L ++S
Sbjct: 791 FIL-ITVIGKLVVLNLFIALLLNSFS 815
Score = 81.4 bits (192), Expect = 3e-14
Identities = 66/266 (24%), Positives = 126/266 (47%), Gaps = 46/266 (17%)
Query: 1258 IFTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFK 1313
+FT I+ E LIK LA GF + + W WLD I++ +++++++ + I+
Sbjct: 165 VFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLLP 220
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
+RT R R L+A+S + ++V+V AL++++ + NV+++ IFA++G QLF G
Sbjct: 221 -LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSL 279
Query: 1374 -FKCVDMNHTTLSH-----------EIIPD---------KNACTLE---NYTWEN---SP 1406
KC+ + +S+ E P+ +AC+++ +T N +
Sbjct: 280 NLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
Query: 1407 MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXX 1466
NFD+ G ++L +F++ T W ++ +Q +R T +Y +
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSF 389
Query: 1467 XTLNLFIGVIIDNFNEQKKKAGGSLE 1492
+NL + V+ + EQ K +E
Sbjct: 390 YLINLTLAVVTMAYEEQNKNVAAEIE 415
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/285 (24%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTVES----TEVIFTGIYTFE 180
+R+ I+ H F FII IL++ +I + P ++ T++IFT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
+K +A GF Y AW LDF+++ ++ T+ I+L L + RT R LR L+ ++
Sbjct: 1105 MVLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTL-INLMELKSFRTLRALRPLRALS 1159
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
G+K +V A+I ++ + +V+++ + VF ++G+ + G KC+ ++
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218
Query: 301 NLTDENWERFCQN-ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDT 359
+T+++ C++ +W + ++ GN+ Y+ L + D
Sbjct: 1219 IITNKSQ---CESGNFSWINQKVNFDNVGNA---------YLALLQVATFKGW----MDI 1262
Query: 360 FGWAFLSAFRLMTQDYWEN-LYQLFFVVIIFLGSFYLVNLILAIV 403
A S + ++ N L ++FVV I GSF+ +NL + ++
Sbjct: 1263 IYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
Score = 74.5 bits (175), Expect = 3e-12
Identities = 43/145 (29%), Positives = 73/145 (50%), Gaps = 8/145 (5%)
Query: 691 EAGKVLKPSSDNPFIESSQQPNVVD----MRDVMVLNEIIEQAGRQSRASELNVSVYYFP 746
E+GK P SD+ + ++P +++ + + L+ E R L+
Sbjct: 473 ESGKDQPPGSDSDE-DCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTI 531
Query: 747 TAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIV 806
T ++ E +E L C + VW+CC WL +K + ++ DPF EL IT+CI+
Sbjct: 532 TMKEQEKS---QEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICII 588
Query: 807 VNTLFMALDHHNMDKDMDKALKSGN 831
+NT+F+A++HH M+ +K L GN
Sbjct: 589 INTVFLAMEHHKMEASFEKMLNIGN 613
Score = 64.1 bits (149), Expect = 5e-09
Identities = 41/162 (25%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTFESA 182
+++V ++ P L I I++N + + M S E ++FT I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMG---IDLGNLAALRTFRVLRALKTV 239
+K++A L P+ Y R WN D +V L++ + + + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
P L T++ + SV L ++ ++ + + +F+++G+Q++
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLF 723
Score = 60.9 bits (141), Expect = 5e-08
Identities = 36/160 (22%), Positives = 81/160 (50%), Gaps = 5/160 (3%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + E A+ I+++++ LA+E H + +L + +FT IF EM +K +A
Sbjct: 573 VMTDPFTELAITICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 630
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
L YF W D I+ ++S + + + +++ +R+ R LR + +
Sbjct: 631 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK---RSWPFLRSFRVLRVFKLAKSWPTL 687
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
++ + ++ ++ N+ +V +I IF+++G+QLF +
Sbjct: 688 NTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSF 727
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/168 (23%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
+++ + F M I+ + +N + M + S + + D +F I+ E L+
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALI 176
Query: 1586 KIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
KI A + + +PWN D +V+ +I+S + I+ L +R +V R
Sbjct: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRTFRVFR 228
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
L+ + ++ ++ AL S+ L N+ +L F + IFA+ G FM
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFM 276
Score = 50.8 bits (116), Expect = 5e-05
Identities = 43/177 (24%), Positives = 85/177 (48%), Gaps = 23/177 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + I+ +F + II+ I++N I M+ + ++ +F I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN----------LAAL 227
E +K+ F L+ + Y + WN D VV+ L+ V TM L N +
Sbjct: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
R R+ R L+ V G++T++ A++ S+ +L ++ +L + ++A++G+ + V
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKV 1522
Score = 41.1 bits (92), Expect = 0.039
Identities = 34/145 (23%), Positives = 70/145 (48%), Gaps = 9/145 (6%)
Query: 792 VFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISI 851
+FD V L + +++TL +H + + ++ R+ +L ++ + L+
Sbjct: 1431 LFDCVVVLLSIVSTMISTLENQ-EHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFA 1489
Query: 852 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK-NYVDYVDRFPDGDLPRWNFTDFMHSFM 910
+ ++ +L N+ +L +I+FI+A++GM F K N +D D+ +NF F S +
Sbjct: 1490 LMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGID-----DI--FNFKTFASSML 1542
Query: 911 IVFRVLCGEWIESMWDCMLVGDVSC 935
+F++ +S+ ML SC
Sbjct: 1543 CLFQISTSAGWDSLLSPMLRSKESC 1567
>M91556-1|AAA59899.1| 1682|Homo sapiens Na+ channel protein.
Length = 1682
Score = 596 bits (1471), Expect = e-169
Identities = 302/721 (41%), Positives = 460/721 (63%), Gaps = 21/721 (2%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W +R K++EN +F+ + + LLS+ LA ED+++ R ++ +L Y D IFT IF
Sbjct: 920 WQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQRKTIKILLEYADMIFTYIF 979
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EML+KW+A GF+ YF+N W LDF++V+V F +L G + K + +++ LRP
Sbjct: 980 ILEMLLKWMAYGFKAYFSNGWYRLDFVVVIV----FCLSLIGKTR-EELKPLISMKFLRP 1034
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--MNH 1381
LR +S+ + M+VVV AL++ NV LVCL+ WLIF+IMGV LFAG++++C+D
Sbjct: 1035 LRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE 1094
Query: 1382 TTLSHEIIPDKNACTL----ENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
S E++ +K+ C E+ WEN+ MNFD+VG +L L QVATF GWI IMN AID
Sbjct: 1095 RFPSSEVM-NKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
S V QP E NIYMY Y L++ I VIIDNFN+ K K GGS +F+T
Sbjct: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGS-NIFITV 1212
Query: 1498 DQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDH 1557
Q+K Y +KK+ + + +PRP + Q +F++VT + F++I+M+ I + M +D
Sbjct: 1213 KQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDT 1272
Query: 1558 YQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLS 1617
QS S L ++N IF+++++ EC+LK+ A R YF WN+FDF+VV+FSI L L
Sbjct: 1273 DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLP 1332
Query: 1618 DIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
+ Y V P+L++++ ++++ +LRL KG K L+ L +SLPAL NI LL+FLVMF
Sbjct: 1333 MTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMF 1392
Query: 1678 IFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE--ECD 1735
I+A+FGM F +VK + G++DV NF+TF SM+ LFQ++ AGWDG+LD I N + +CD
Sbjct: 1393 IYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCD 1452
Query: 1736 LPDNERGSP--GNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTD 1793
G+ G+CG+ ++GI Y +SY++IS+LI++NMYI V++E + A++ + L++
Sbjct: 1453 PDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSE 1512
Query: 1794 DDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMM 1853
DD+ ++++W+RFDPD +QYI +LSDF L+PPL + KPNK ++I++D+P+ GD +
Sbjct: 1513 DDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRI 1572
Query: 1854 FCVDILDALTKDFFARKGNPIEETGDLEVG----RPEEAGYEPVSSTLWRQREEYCARLI 1909
C+DIL A TK + + ++E G P + EP+++TL R++E A +I
Sbjct: 1573 HCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATII 1632
Query: 1910 Q 1910
Q
Sbjct: 1633 Q 1633
Score = 287 bits (703), Expect = 4e-76
Identities = 156/362 (43%), Positives = 218/362 (60%), Gaps = 19/362 (5%)
Query: 62 QPDATLEQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQ-TTFVVISKGKDIFRFSATNA 120
+P+ LE G LP + G+ + S PLED+DP+Y+ + TF+V++K + IFRF+A +
Sbjct: 39 KPNPDLEVGKKLPF-IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASI 97
Query: 121 LWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST-EVIFTGIYTF 179
L L PFN IRR I +LVHP F LFI+ ++L++C+ M + P E GIYTF
Sbjct: 98 LCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTF 157
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTV 239
E VK+ ARG F++L D WNWLDF V + L + L+T R LR LK +
Sbjct: 158 EILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKII 217
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW 299
+ GLK++VG +I +K L VIILT+F LS+F+L+G+ ++MG L KC + +P++
Sbjct: 218 PLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFR-WPQENEN 276
Query: 300 GNLTDENWERFCQNETN--WYGEGGDYP-LCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
L + + ET +Y EG Y LCGN + AGQC GYVC++ G NP+ G+T+
Sbjct: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKA-GINPDQGFTN 335
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILAIVAM 405
FD+FGWA + FRLM QDY E LY L FFVV+ FL SFY+ +L L I+AM
Sbjct: 336 FDSFGWALFALFRLMAQDYPEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGILAM 395
Query: 406 SY 407
+Y
Sbjct: 396 AY 397
Score = 125 bits (301), Expect = 2e-27
Identities = 56/115 (48%), Positives = 76/115 (66%), Gaps = 2/115 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FKL K WPT +L+ + + AL +L +L IF A GM+LFGKNY ++V
Sbjct: 601 LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
Query: 893 P-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVVI 945
D LPRW+ DF HSF+ VFR+LCGEW+E++WDCM + G CIPF+L ++I
Sbjct: 661 DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILI 715
Score = 89.4 bits (212), Expect = 1e-16
Identities = 55/169 (32%), Positives = 95/169 (56%), Gaps = 10/169 (5%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + V I+ D+ +++ I LN+ +TL+HY S+ + +L+ N++FI IF
Sbjct: 489 PCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIF 548
Query: 1580 SSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E + KI A+ Y YF WN+FD ++V ++ L L+++ LLR+ R+
Sbjct: 549 TAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-----AGMALLRLFRML-- 601
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R+ +L K + L+++L+ S AL ++ LLLF +F A FGM F
Sbjct: 602 -RIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/172 (25%), Positives = 89/172 (51%), Gaps = 13/172 (7%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPH-RPILQDILYYMDRIFTVIFFI 1265
+R T K++ + +F+ ++ +L+ + ++L +LP RP+L++ L I+T +
Sbjct: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSL--TNLPKWRPVLENTLL---GIYTFEILV 161
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
++ + + G + + W WLDF + + +I + L T++T R LR L+
Sbjct: 162 KLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPL------DFIPTLQTARTLRILK 215
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKC 1376
+ QG++ +V L+ + + V+++ L F IF+++G+ LF G KC
Sbjct: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKC 267
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/178 (22%), Positives = 87/178 (48%), Gaps = 13/178 (7%)
Query: 113 FRFSATNALWILDP-FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ T +W P + ++ I++ P LF+I I++N + + P + T
Sbjct: 476 YKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNT 535
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++F GI+T E K++A + P+ Y + WN D +++ + + + ++
Sbjct: 536 LLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAG 591
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+A LR FR+LR K P + ++ ++ S L+D+++L + A G++++
Sbjct: 592 MALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
Score = 60.9 bits (141), Expect = 5e-08
Identities = 21/60 (35%), Positives = 38/60 (63%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +W+C WL+ +++V ++ PF +LF+ +CI++N F+ L+H+ M K + L GN
Sbjct: 482 FLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGN 541
Score = 54.0 bits (124), Expect = 5e-06
Identities = 33/119 (27%), Positives = 64/119 (53%), Gaps = 5/119 (4%)
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-GIDLGNL 224
+E ++IFT I+ E +K MA GF Y + W LDFVV+ + +++ G L
Sbjct: 968 LEYADMIFTYIFILEMLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREEL 1023
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L + + LR L+ ++ +K +V A+I++ +V ++ + +F++MG+ ++ G
Sbjct: 1024 KPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
Score = 48.4 bits (110), Expect = 3e-04
Identities = 32/117 (27%), Positives = 61/117 (52%), Gaps = 16/117 (13%)
Query: 1578 IFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPT-LLR 1631
I++ E L+K+FA + + +PWN DF V +F ++I +Y SP +
Sbjct: 154 IYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVF--------EVIIRY--SPLDFIP 203
Query: 1632 VVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ A+ R+L+++ +G+++L+ L L L + +L + IF++ GM FM
Sbjct: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFM 260
Score = 47.6 bits (108), Expect = 4e-04
Identities = 47/178 (26%), Positives = 79/178 (44%), Gaps = 14/178 (7%)
Query: 1198 SPFWQGWGTLRLKTF--KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYM 1255
SP W L+LK F ++I + + +I I+L+ L LE H P +L
Sbjct: 488 SPCW-----LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLE--HYPMSKQTNTLLNIG 540
Query: 1256 DRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTM 1315
+ +F IF EM+ K +A+ YF W D +IV LI LC A + +
Sbjct: 541 NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIE----LCLA-NVAGMALL 595
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
R R LR + ++++ +L + ++ +++L+ F A G++LF Y
Sbjct: 596 RLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNY 653
Score = 33.5 bits (73), Expect = 7.8
Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 7/79 (8%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIF-IFAVMGMQLFGK 883
K L S +LR ++ + + +++ + +T N+ F++C++I+ IF++MG+ LF
Sbjct: 1024 KPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNV-FLVCLMIWLIFSIMGVDLFAG 1082
Query: 884 NYVDYVD-----RFPDGDL 897
+ + +D RFP ++
Sbjct: 1083 RFYECIDPTSGERFPSSEV 1101
>AB037777-1|BAA92594.1| 519|Homo sapiens KIAA1356 protein protein.
Length = 519
Score = 487 bits (1202), Expect = e-136
Identities = 231/427 (54%), Positives = 321/427 (75%), Gaps = 8/427 (1%)
Query: 1492 EMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNML 1551
++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +VF+ VT + FD+ IM+ I LNM+
Sbjct: 1 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMV 60
Query: 1552 TMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSI 1611
TM ++ Q + + VL +N++FIV+F+ E +LK+ +LR++YF WN+FDFVVV+ SI
Sbjct: 61 TMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSI 120
Query: 1612 LSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLL 1671
+ + L+++IEKYFVSPTL RV+R+A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LL
Sbjct: 121 VGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 180
Query: 1672 LFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE 1731
LFLVMFI+AIFGMS F +VK + G+DD++NF+TF SMI LFQ++TSAGWDG+L I+N
Sbjct: 181 LFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 240
Query: 1732 --EECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+CD GS G+CG+ ++GI + +SY++ISFL+V+NMYIAVILEN+S ATE+
Sbjct: 241 APPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEES 300
Query: 1788 QEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPI 1847
E L++DD++M+YE+W++FDPD +Q+I + +LSDF L+PPL I KPNK ++I+MD+P+
Sbjct: 301 AEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPM 360
Query: 1848 CRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRPEEAGYEPVSSTLWRQREE 1903
GD + C+DIL A TK G I+ P + YEP+++TL R++EE
Sbjct: 361 VSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEE 420
Query: 1904 YCARLIQ 1910
A +IQ
Sbjct: 421 VSAAIIQ 427
Score = 70.1 bits (164), Expect = 7e-11
Identities = 58/230 (25%), Positives = 112/230 (48%), Gaps = 31/230 (13%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
F + F+ +++ +I L+ + + +E L +L ++ +F V+F E ++K
Sbjct: 39 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTL--VLSRINLVFIVLFTGEFVLKL 96
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLIN-FVAALCGAGGIQA--FKTMRTLRALRPLRAMS 1328
++L YFT W DF++V++S++ F+A + + F+ +R R R LR +
Sbjct: 97 VSLRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIK 155
Query: 1329 RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI 1388
+G+R ++ AL+ ++P++FN+ L+ + I+AI G+ FA Y K
Sbjct: 156 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVK------------- 200
Query: 1389 IPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
K A + NF+ G + +CLFQ+ T GW ++ ++S
Sbjct: 201 ---KEAGI-------DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 240
Score = 41.5 bits (93), Expect = 0.029
Identities = 36/169 (21%), Positives = 79/169 (46%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + + +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 30 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 89
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 90 GEFVLKLVS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 144
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 145 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 193
Score = 37.9 bits (84), Expect = 0.36
Identities = 29/140 (20%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 800 FITLCIVVNTLFMA--LDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMG 857
F+ + + + +F+A ++ + + + + ++ R+ +L K + L+ + ++
Sbjct: 113 FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 172
Query: 858 ALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC 917
AL N+ +L +++FI+A+ GM F YV + D +NF F +S + +F++
Sbjct: 173 ALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEAGID-DMFNFETFGNSMICLFQIT- 225
Query: 918 GEWIESMWDCMLVGDVSCIP 937
+ WD +L ++ P
Sbjct: 226 ---TSAGWDGLLAPILNSAP 242
>AF150882-1|AAF24980.1| 1444|Homo sapiens voltage-gated sodium channel
alpha subunit, alternate splice variant SCN12A-s protein.
Length = 1444
Score = 471 bits (1160), Expect = e-131
Identities = 229/444 (51%), Positives = 311/444 (70%), Gaps = 8/444 (1%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E V P C P+ FP + D P W W LR ++++++++FE+ +I +IL
Sbjct: 1008 EMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVIL 1067
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDF 1289
LSS AL EDVHL ++P +Q++L D IFT IF +EM++KW+A GF KYFT+AWC LDF
Sbjct: 1068 LSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDF 1127
Query: 1290 IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFN 1349
IIV+VS+ + + K+ RTLRALRPLRA+S+ +GM+VVVNAL+ AIP+I N
Sbjct: 1128 IIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILN 1180
Query: 1350 VLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNF 1409
VLLVCLIFWL+F I+GV F+GK+ KC++ + +++ II +K+ C N++W N +NF
Sbjct: 1181 VLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNF 1240
Query: 1410 DHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTL 1469
D+VG AYL L QVATFKGW+ I+ A+DS E +QP E+N Y+Y TL
Sbjct: 1241 DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTL 1300
Query: 1470 NLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIV 1529
NLFIGVIIDNFN+Q+KK GG ++FMTE+QKKYYNAMKK+GSKKP K IPRP + Q +V
Sbjct: 1301 NLFIGVIIDNFNQQQKKLGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
Query: 1530 FEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA 1589
F+IVT + FD+II+ I LNM++M + Y Q + ++LD+LN +F+VIF+ ECL+KIFA
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
Query: 1590 LRYHYFVEPWNLFDFVVVMFSILS 1613
LR +YF WNLFD VVV+ SI+S
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVS 1443
Score = 326 bits (800), Expect = 6e-88
Identities = 185/418 (44%), Positives = 252/418 (60%), Gaps = 41/418 (9%)
Query: 8 ISEEERSLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATL 67
I +ER+ FRPFT +SL K+K K GEV P+P L
Sbjct: 9 IFPDERN-FRPFTSDSLAAIEKRIAIQKEKKKS---KDQTGEVPQ--------PRPQLDL 56
Query: 68 EQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPF 127
+ LP ++ G P EL PLED+DPFY N TF+V+++ + I+RFSA +AL+I PF
Sbjct: 57 KASRKLP-KLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPF 115
Query: 128 NPIRRVAIYILVHPLFSLFIITTILVNCILMIM-----PTTPTVESTEVIFTGIYTFESA 182
N IR +AI + VH LFS+FII T+++NC+ M + + E +FTGIY FE+
Sbjct: 116 NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEAL 175
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM--GIDLGNLAALRTFRVLRALKTVA 240
+K++ARGFIL F++LRD WNWLD +VI +A V+ GI + L LRTFRV RALK ++
Sbjct: 176 IKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAIS 234
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
+V LK IVGA++ SVK L +VIILT F LS+FAL+G Q++MG L KC+ ++ S
Sbjct: 235 VVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS-- 292
Query: 301 NLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTF 360
E ++ + + N ++ +CG G C Y C + NP+Y YT+FD F
Sbjct: 293 --NPEAYDHCFEKKEN----SPEFKMCGIWMGNSACSIQYEC-KHTKINPDYNYTNFDNF 345
Query: 361 GWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
GW+FL+ FRLMTQD WE LYQ FF+V+IFLGSFYL+NL LA+V M+Y
Sbjct: 346 GWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAY 403
Score = 136 bits (329), Expect = 7e-31
Identities = 69/129 (53%), Positives = 88/129 (68%), Gaps = 10/129 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN LI I+G ++GALGNLT VL I+IFIF+V+GMQLFG+++
Sbjct: 669 LRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSFN 728
Query: 887 DYVDR---FPDGD----LPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVS---CI 936
P G L W+ DF HSF++VFR+LCGEWIE+MW+CM + S C+
Sbjct: 729 SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCV 788
Query: 937 PFFLATVVI 945
F+ VI
Sbjct: 789 IVFILITVI 797
Score = 96.7 bits (230), Expect = 7e-19
Identities = 76/266 (28%), Positives = 137/266 (51%), Gaps = 16/266 (6%)
Query: 1521 PRWR-PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P+W + ++ ++TD ++ I + I +N + + ++H++ +F +L+ N++F IF
Sbjct: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
+E LKI AL YHYF WN+FD +V + S V++ +++K S LR RV
Sbjct: 621 IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKR--SWPFLRSFRVL-- 675
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDD 1698
RV +L K + TL+ + S+ AL N+ ++L +V+FIF++ GM F +
Sbjct: 676 -RVFKLAKSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPK 734
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC-DLPDN--ERGSPGNCGSATIGIT 1755
+ N S + + M W L ++ C + +N E N S+ I
Sbjct: 735 LCNPTGPTVSCLRHWHMGDF--WHSFL--VVFRILCGEWIENMWECMQEANASSSLCVIV 790
Query: 1756 YLLSYLVISFLIVINMYIAVILENYS 1781
++L VI L+V+N++IA++L ++S
Sbjct: 791 FIL-ITVIGKLVVLNLFIALLLNSFS 815
Score = 81.4 bits (192), Expect = 3e-14
Identities = 66/266 (24%), Positives = 126/266 (47%), Gaps = 46/266 (17%)
Query: 1258 IFTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFK 1313
+FT I+ E LIK LA GF + + W WLD I++ +++++++ + I+
Sbjct: 165 VFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLLP 220
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
+RT R R L+A+S + ++V+V AL++++ + NV+++ IFA++G QLF G
Sbjct: 221 -LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSL 279
Query: 1374 -FKCVDMNHTTLSH-----------EIIPD---------KNACTLE---NYTWEN---SP 1406
KC+ + +S+ E P+ +AC+++ +T N +
Sbjct: 280 NLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
Query: 1407 MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXX 1466
NFD+ G ++L +F++ T W ++ +Q +R T +Y +
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSF 389
Query: 1467 XTLNLFIGVIIDNFNEQKKKAGGSLE 1492
+NL + V+ + EQ K +E
Sbjct: 390 YLINLTLAVVTMAYEEQNKNVAAEIE 415
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/285 (24%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMI-----MPTTPTVES----TEVIFTGIYTFE 180
+R+ I+ H F FII IL++ +I + P ++ T++IFT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
+K +A GF Y AW LDF+++ ++ T+ I+L L + RT R LR L+ ++
Sbjct: 1105 MVLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTL-INLMELKSFRTLRALRPLRALS 1159
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWG 300
G+K +V A+I ++ + +V+++ + VF ++G+ + G KC+ ++
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218
Query: 301 NLTDENWERFCQN-ETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDT 359
+T+++ C++ +W + ++ GN+ Y+ L + D
Sbjct: 1219 IITNKSQ---CESGNFSWINQKVNFDNVGNA---------YLALLQVATFKGW----MDI 1262
Query: 360 FGWAFLSAFRLMTQDYWEN-LYQLFFVVIIFLGSFYLVNLILAIV 403
A S + ++ N L ++FVV I GSF+ +NL + ++
Sbjct: 1263 IYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
Score = 74.9 bits (176), Expect = 3e-12
Identities = 70/314 (22%), Positives = 139/314 (44%), Gaps = 49/314 (15%)
Query: 1523 WRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFS 1580
W + ++IV F+ I+ I L+ + + H + +L+ ++IF IF
Sbjct: 1043 WNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFI 1102
Query: 1581 SECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
E +LK A + YF W DF++V+ S+ +L+ +++E L+ R +
Sbjct: 1103 LEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI--NLME--------LKSFRTLRAL 1152
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDK--GGLD 1697
R LR + +G++ ++ AL ++PA+ N+ L+ + +F I G+ FF K G D
Sbjct: 1153 RPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTD 1212
Query: 1698 DV-----------------------YNFKTFVQSMILLFQMSTSAGW-DGVLDGIINEEE 1733
V NF + + L Q++T GW D + + + E+
Sbjct: 1213 SVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEK 1272
Query: 1734 CDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV--QEGL 1791
P+ E S ++G Y + +++ +N++I VI++N++Q + + Q+
Sbjct: 1273 EQQPEFE--------SNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIF 1324
Query: 1792 TDDDYDMYYEIWQR 1805
++ YY ++
Sbjct: 1325 MTEEQKKYYNAMKK 1338
Score = 74.5 bits (175), Expect = 3e-12
Identities = 43/145 (29%), Positives = 73/145 (50%), Gaps = 8/145 (5%)
Query: 691 EAGKVLKPSSDNPFIESSQQPNVVD----MRDVMVLNEIIEQAGRQSRASELNVSVYYFP 746
E+GK P SD+ + ++P +++ + + L+ E R L+
Sbjct: 473 ESGKDQPPGSDSDE-DCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTI 531
Query: 747 TAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIV 806
T ++ E +E L C + VW+CC WL +K + ++ DPF EL IT+CI+
Sbjct: 532 TMKEQEKS---QEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICII 588
Query: 807 VNTLFMALDHHNMDKDMDKALKSGN 831
+NT+F+A++HH M+ +K L GN
Sbjct: 589 INTVFLAMEHHKMEASFEKMLNIGN 613
Score = 64.1 bits (149), Expect = 5e-09
Identities = 41/162 (25%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTFESA 182
+++V ++ P L I I++N + + M S E ++FT I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 183 VKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMG---IDLGNLAALRTFRVLRALKTV 239
+K++A L P+ Y R WN D +V L++ + + + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
P L T++ + SV L ++ ++ + + +F+++G+Q++
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLF 723
Score = 60.9 bits (141), Expect = 5e-08
Identities = 36/160 (22%), Positives = 81/160 (50%), Gaps = 5/160 (3%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + E A+ I+++++ LA+E H + +L + +FT IF EM +K +A
Sbjct: 573 VMTDPFTELAITICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 630
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
L YF W D I+ ++S + + + +++ +R+ R LR + +
Sbjct: 631 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK---RSWPFLRSFRVLRVFKLAKSWPTL 687
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
++ + ++ ++ N+ +V +I IF+++G+QLF +
Sbjct: 688 NTLIKIIGNSVGALGNLTVVLVIVIFIFSVVGMQLFGRSF 727
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/168 (23%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
+++ + F M I+ + +N + M + S + + D +F I+ E L+
Sbjct: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALI 176
Query: 1586 KIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
KI A + + +PWN D +V+ +I+S + I+ L +R +V R
Sbjct: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRTFRVFR 228
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
L+ + ++ ++ AL S+ L N+ +L F + IFA+ G FM
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFM 276
Score = 36.7 bits (81), Expect = 0.84
Identities = 25/98 (25%), Positives = 47/98 (47%), Gaps = 12/98 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + I+ +F + II+ I++N I M+ + ++ +F I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVT 216
E +K+ F L+ + Y + WN D VV+ L+ V+
Sbjct: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVS 1443
>X65362-1|CAA46439.1| 423|Homo sapiens sodium channel protein.
Length = 423
Score = 450 bits (1109), Expect = e-125
Identities = 212/406 (52%), Positives = 304/406 (74%), Gaps = 8/406 (1%)
Query: 1513 KPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLN 1572
KP K IPRP + Q +VF++VT + FD+ IM+ I LNM+TM ++ QSE + +L +N
Sbjct: 1 KPQKPIPRPGNKFQGMVFDLVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRIN 60
Query: 1573 MIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
++FIV+F+ EC+LK+ +LR++YF WN+FDFVVV+ SI+ + L+++IEKYFVSPTL RV
Sbjct: 61 LVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRV 120
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKD 1692
+R+A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LLLFLVMFI+AIFGMS F +VK
Sbjct: 121 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 180
Query: 1693 KGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE--ECDLPDNERGS--PGNCG 1748
+ G+DD++NF+TF SMI LFQ++TSAGWDG+L I+N + +CD GS G+CG
Sbjct: 181 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCG 240
Query: 1749 SATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDP 1808
+ ++GI + +SY++ISFL+V+NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDP
Sbjct: 241 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 300
Query: 1809 DGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFA 1868
D +Q++ +++LS F LEPPL + +PNK ++I+MD+P+ GD + C+DIL A TK
Sbjct: 301 DATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 360
Query: 1869 RKGN----PIEETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
G I+ P + Y+P+++TL R++EE A +IQ
Sbjct: 361 ESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQ 406
Score = 75.8 bits (178), Expect = 1e-12
Identities = 72/312 (23%), Positives = 144/312 (46%), Gaps = 47/312 (15%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKW 1271
F L+ F+ +++ +I L+ + + +E + IL ++ +F V+F E ++K
Sbjct: 18 FDLVTRQVFDISIMILICLNMVTMMVETDD--QSEYVTTILSRINLVFIVLFTGECVLKL 75
Query: 1272 LALGFQKYFTNAWCWLDFIIVMVSLIN-FVAALCGAGGIQA--FKTMRTLRALRPLRAMS 1328
++L YFT W DF++V++S++ F+A L + F+ +R R R LR +
Sbjct: 76 ISLRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 134
Query: 1329 RMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI 1388
+G+R ++ AL+ ++P++FN+ L+ + I+AI G+ FA Y K E+
Sbjct: 135 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVK----------REV 182
Query: 1389 IPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR- 1447
D NF+ G + +CLFQ+ T GW ++ ++S+ P +
Sbjct: 183 GID-------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKV 229
Query: 1448 -----------ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
++ ++ + +N++I VI++NF+ ++ S E
Sbjct: 230 NPGSSVKGDCGNPSVGIFFF-VSYIIISFLVVVNMYIAVILENFSVATEE---SAEPLSE 285
Query: 1497 EDQKKYYNAMKK 1508
+D + +Y +K
Sbjct: 286 DDFEMFYEVWEK 297
Score = 42.7 bits (96), Expect = 0.013
Identities = 36/169 (21%), Positives = 80/169 (47%), Gaps = 21/169 (12%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P N + + ++ +F + I+ I +N + M++ T T + ++F ++T
Sbjct: 9 PGNKFQGMVFDLVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 68
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM---------GIDLGNLAALRT 229
E +K+++ L+ + Y WN DFVV+ L+ V M + +R
Sbjct: 69 GECVLKLIS----LRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 123
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
R+ R L+ + G++T++ A++ S+ L ++ +L + ++A+ G+
Sbjct: 124 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 172
Score = 39.9 bits (89), Expect = 0.090
Identities = 30/140 (21%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 776 DCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRV 835
+C + + Y + ++ F + + L IV L ++ + + + + ++ R+
Sbjct: 70 ECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRI 129
Query: 836 FKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG 895
+L K + L+ + ++ AL N+ +L +++FI+A+ GM F YV R
Sbjct: 130 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKREVGI 184
Query: 896 DLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 185 D-DMFNFETFGNSMICLFQI 203
>AB208888-1|BAD92125.1| 1315|Homo sapiens Sodium channel protein
type II alpha subunit variant protein.
Length = 1315
Score = 438 bits (1079), Expect = e-121
Identities = 231/426 (54%), Positives = 296/426 (69%), Gaps = 45/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL K+ + E+K + E GP+P++ LE G LP
Sbjct: 21 FRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDE---------NGPKPNSDLEAGKSLPF 71
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK I RFSAT AL+IL PFNPIR++AI
Sbjct: 72 -IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 130
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LF++ I+ TIL NC+ M M P ++ E FTGIYTFES +K++ARGF L+
Sbjct: 131 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 190
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 191 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 250
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSW-------------GN 301
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P++ S+ GN
Sbjct: 251 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 310
Query: 302 LTD-------ENWERFCQNETNWYG-EG-GDYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
T NW+ + ++++++Y EG D LCGNSS AGQC GY+C++ G NPNY
Sbjct: 311 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNY 369
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQD+WENLYQL FFV++IFLGSFYL+NLILA
Sbjct: 370 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 429
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 430 VVAMAY 435
Score = 286 bits (701), Expect = 6e-76
Identities = 171/483 (35%), Positives = 254/483 (52%), Gaps = 40/483 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT VL II+FIFAV+GMQLFGK+Y
Sbjct: 856 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 915
Query: 887 DYVDRFP-DGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVV 944
+ V + D +LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ F+ +V
Sbjct: 916 ECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMV 975
Query: 945 IXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLL 1004
I D + N + A R+ + ID++KR + +F+
Sbjct: 976 IGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFI--- 1032
Query: 1005 KNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYK 1064
Q A ++ +E++ DL++ KD + + + IG + N K
Sbjct: 1033 ------QKAFVRKQKALDEIKPLEDLNNK---KDSCISNHTTIEIGKDL-------NYLK 1076
Query: 1065 KGKILMNNINAITDNHRDNRLD--CELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKG 1122
G + I + + + + D +N+ + + + + + F ES
Sbjct: 1077 DGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES--- 1133
Query: 1123 SADTIDGEEKKDASXXXXXXXXXXXXXXXXXXXXGTLGKTDIKVGADEDVVDDTPADCCP 1182
D + +EK +A+ G+ +V +E + P C
Sbjct: 1134 --DMEESKEKLNATSSSEGSTVDIGAPAE--------GEQP-EVEPEESL---EPEACFT 1179
Query: 1183 EQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHL 1242
E C +KF + + W LR +K++E+ +FET ++ MILLSS ALA ED+++
Sbjct: 1180 EDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI 1239
Query: 1243 PHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA 1302
R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWCWLDF+IV VS+++F A
Sbjct: 1240 EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSMLHFAAL 1299
Query: 1303 LCG 1305
G
Sbjct: 1300 FIG 1302
Score = 104 bits (250), Expect = 3e-21
Identities = 86/287 (29%), Positives = 150/287 (52%), Gaps = 37/287 (12%)
Query: 1520 RPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
+P + + +V +V D D+ I + I LN L M ++HY +E FS+VL N++F IF
Sbjct: 750 KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 809
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E LKI A+ Y+YF E WN+FD +V S++ L L+++ L V+R ++
Sbjct: 810 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 861
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-MHVKD---KG 1694
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F K+ K
Sbjct: 862 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 921
Query: 1695 GLD---DVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSAT 1751
D ++ F S +++F+ VL G E D + T
Sbjct: 922 SNDCELPRWHMHDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQT 964
Query: 1752 IGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
+ +T + +VI L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 965 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 1007
Score = 79.4 bits (187), Expect = 1e-13
Identities = 38/99 (38%), Positives = 58/99 (58%), Gaps = 3/99 (3%)
Query: 733 SRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLV 792
SR ++++ T E+ E+ ++K C K + +WDCC WL+ + V L+V
Sbjct: 707 SRQRAMSIASILTNTMEELEES---RQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVV 763
Query: 793 FDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 764 MDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN 802
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/187 (25%), Positives = 99/187 (52%), Gaps = 14/187 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
++F+ +W P+ ++ + +++ P L I I++N + M M P E
Sbjct: 737 YKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 796
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D +++L+ + +G+ ++
Sbjct: 797 VLSVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG 852
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 853 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 911
Query: 284 VLTQKCV 290
++CV
Sbjct: 912 KSYKECV 918
Score = 76.2 bits (179), Expect = 1e-12
Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM +K +A
Sbjct: 762 VVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIA 819
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IV +SL+ G ++ +R+ R LR + +
Sbjct: 820 MDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVEGLSVLRSFRLLRVFKLAKSWPTL 874
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 875 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 918
Score = 72.9 bits (171), Expect = 1e-11
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 11/135 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF ++ + +V G + A
Sbjct: 169 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA---YVTEFVDLGNVSA--- 222
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 223 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 282
Query: 1374 FKCVDMNHTTLSHEI 1388
KC+ S EI
Sbjct: 283 NKCLQWPPDNSSFEI 297
Score = 56.0 bits (129), Expect = 1e-06
Identities = 44/166 (26%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+ +I+ F+M+IM I N + MT+ + ++ ++Y F I++ E L+KI
Sbjct: 128 LAIKILVHSLFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYT---FTGIYTFESLIKI 181
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ F+ ++ FV + +R +V R L
Sbjct: 182 LARGFCLEDFTFLRDPWNWLDFTVITFAYVT---------EFVDLGNVSALRTFRVLRAL 232
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 233 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 278
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1523 WRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFS 1580
W + ++IV F+ I+ I L+ + + + +Q +T +L+Y + +F IF
Sbjct: 1202 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1261
Query: 1581 SECLLKIFALRYH-YFVEPWNLFDFVVVMFSIL 1612
E LLK A + YF W DF++V S+L
Sbjct: 1262 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSML 1294
Score = 36.3 bits (80), Expect = 1.1
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 13/90 (14%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1204 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1263
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVI 210
+K +A GF + Y +AW WLDF+++
Sbjct: 1264 MLLKWVAYGFQV----YFTNAWCWLDFLIV 1289
>AF035686-1|AAC29515.1| 1366|Homo sapiens voltage-gated sodium
channel, subtype III protein.
Length = 1366
Score = 427 bits (1051), Expect = e-118
Identities = 226/426 (53%), Positives = 292/426 (68%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ RGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILVRGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDNIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYTIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 264 bits (646), Expect = 3e-69
Identities = 135/256 (52%), Positives = 174/256 (67%), Gaps = 7/256 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWC LDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCRLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKN---ACTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVAT 1424
FD+VG YL L QV +
Sbjct: 1351 FDNVGAGYLALLQVVS 1366
Score = 181 bits (440), Expect = 3e-44
Identities = 101/263 (38%), Positives = 142/263 (53%), Gaps = 6/263 (2%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNEL--ELGTDLDDAVLYKDKK 1040
R+ + ID++K + + + + I IH ++D+ + G ++ A+ Y
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKALNYLRDG 1018
Query: 1041 LKDQVEVAIGDGMEFTIPGDNKY 1063
V G +E + +N Y
Sbjct: 1019 NGTTSGVGTGSSVEKYVIDENDY 1041
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 74.5 bits (175), Expect = 3e-12
Identities = 47/168 (27%), Positives = 85/168 (50%), Gaps = 6/168 (3%)
Query: 1523 WRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFS 1580
W + + IV F+ I+ I L+ + + + +Q +T +L+Y + +F IF
Sbjct: 1144 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1203
Query: 1581 SECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
E LLK A + YF W DF++V S++SLV + + + LR +R
Sbjct: 1204 LEMLLKWVAYGFQTYFTNAWCRLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL--- 1260
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R LR + +G+R ++ AL ++P++ N+ L+ + IF+I G++ F
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1308
Score = 70.9 bits (166), Expect = 4e-11
Identities = 38/117 (32%), Positives = 68/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK L GF + + W WLDF +++++ +V G + A +T
Sbjct: 161 FTGIYTFESLIKILVRGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVDLGNVSALRT 217
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 218 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 70.1 bits (164), Expect = 7e-11
Identities = 51/198 (25%), Positives = 103/198 (52%), Gaps = 22/198 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW LDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCRLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ 312
G+ +++D N CQ
Sbjct: 1319 TTGNMFDISDVNNLSDCQ 1336
Score = 55.2 bits (127), Expect = 2e-06
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FV + +R +V R L
Sbjct: 174 LVRGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVDLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
>AF035685-1|AAC29514.1| 1366|Homo sapiens voltage-gated sodium
channel, subtype III protein.
Length = 1366
Score = 424 bits (1045), Expect = e-117
Identities = 225/426 (52%), Positives = 291/426 (68%), Gaps = 46/426 (10%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
FR FTRESL +K +++A+ + P+P++ LE G LP
Sbjct: 14 FRLFTRESLAAI----------EKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P E+ S PLED+DP+Y N+ TF+V++KGK IFRFSAT+AL+IL P NP+R++AI
Sbjct: 64 -IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAI 122
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NC+ M + P ++ E FTGIYTFES +K++ RGF L+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILVRGFCLED 182
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDF VI +AYVT + LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 183 FTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 242
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPED------------------ 296
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC++ P D
Sbjct: 243 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSN 302
Query: 297 GSWGNLTDE--NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYVCLQGFGPNPNY 352
G++ N+T NW+ +++++Y G D LCGN S AGQC GY+C++ G NPNY
Sbjct: 303 GTFVNVTMSTFNWKDNIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKA-GRNPNY 361
Query: 353 GYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFLGSFYLVNLILA 401
GYTSFDTF WAFLS FRLMTQDYWENLYQL FFV++IFLGSFYLVNLILA
Sbjct: 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYTIFFVLVIFLGSFYLVNLILA 421
Query: 402 IVAMSY 407
+VAM+Y
Sbjct: 422 VVAMAY 427
Score = 264 bits (646), Expect = 3e-69
Identities = 135/256 (52%), Positives = 174/256 (67%), Gaps = 7/256 (2%)
Query: 1174 DDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSL 1233
D P C E C +KFPF + + W LR + ++E+ +FET ++ MILLSS
Sbjct: 1113 DLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSG 1172
Query: 1234 ALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVM 1293
ALA ED+++ R ++ +L Y D++FT IF +EML+KW+A GFQ YFTNAWC LDF+IV
Sbjct: 1173 ALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCRLDFLIVD 1232
Query: 1294 VSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1353
VSL++ VA G + A K++RTLRALRPLRA+SR +GMRVVVNALV AIPSI NVLLV
Sbjct: 1233 VSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1292
Query: 1354 CLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKN---ACTL--ENYTWENSPMN 1408
CLIFWLIF+IMGV LFAGK++ CV+M TT + I D N C + W+N +N
Sbjct: 1293 CLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1409 FDHVGKAYLCLFQVAT 1424
FD+VG YL L QV +
Sbjct: 1351 FDNVGAGYLALLQVVS 1366
Score = 181 bits (440), Expect = 3e-44
Identities = 101/263 (38%), Positives = 142/263 (53%), Gaps = 6/263 (2%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
I+V+ M L N++ L+S LRVFKLAKSWPTLN+LI I+G ++GALGNLT
Sbjct: 781 IIVSLSLMELGLSNVEGL--SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
Query: 865 VLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIES 923
VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFRVLCGEWIE+
Sbjct: 839 VLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIET 898
Query: 924 MWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTADQDTNKIAEA 982
MWDCM + G C+ F+ +VI D + N + A
Sbjct: 899 MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIA 958
Query: 983 FNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNEL--ELGTDLDDAVLYKDKK 1040
R+ + ID++K + + + + I IH ++D+ + G ++ A+ Y
Sbjct: 959 VGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKALNYLRDG 1018
Query: 1041 LKDQVEVAIGDGMEFTIPGDNKY 1063
V G +E + +N Y
Sbjct: 1019 NGTTSGVGTGSSVEKYVIDENDY 1041
Score = 105 bits (252), Expect = 2e-21
Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 39/276 (14%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL- 1590
IV D D+ I + I LN L M ++HY +E FS+VL N++F IF++E +LKI A+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 1591 RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y+YF E WN+FD ++V S++ L LS++ L V+R ++ RV +L K
Sbjct: 767 PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHVKDKGGLDDVYNF 1702
+ L+ + S+ AL N+ L+L +++FIFA+ GM F + D L ++
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPR-WHM 877
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
F S +++F+ VL G E D + T+ + + +V
Sbjct: 878 NDFFHSFLIVFR---------VLCGEWIETMWDCME--------VAGQTMCLIVFMLVMV 920
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
I L+V+N+++A++L ++S ++++ TDDD +M
Sbjct: 921 IGNLVVLNLFLALLLSSFS--SDNL--AATDDDNEM 952
Score = 83.8 bits (198), Expect = 6e-15
Identities = 50/193 (25%), Positives = 102/193 (52%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALW-ILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W D + ++ + I++ P L I I++N + M M P E
Sbjct: 682 YRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS 741
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+T E +K++A + P+ Y ++ WN D ++++L+ + +G+ ++
Sbjct: 742 VLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 856
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 857 KSYKECVCKINDD 869
Score = 82.2 bits (194), Expect = 2e-14
Identities = 40/108 (37%), Positives = 65/108 (60%), Gaps = 5/108 (4%)
Query: 724 EIIEQAGRQSRASELNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLE 783
E++E + + RA ++++ T E+ E+ ++K C + + F +WDCC WL+
Sbjct: 645 EMLEDSSGRQRA--VSIASILTNTMEELEES---RQKCPPCWYRFANVFLIWDCCDAWLK 699
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
+ V L+V DPFV+L IT+CIV+NTLFMA++H+ M + L GN
Sbjct: 700 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 7/164 (4%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ + + + A+ I+L++L +A+E H P +L + +FT IF EM++K +A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAME--HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 764
Query: 1274 LGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
+ YF W D IIV +SL+ G ++ +R+ R LR + +
Sbjct: 765 MDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVEGLSVLRSFRLLRVFKLAKSWPTL 819
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 820 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 863
Score = 74.5 bits (175), Expect = 3e-12
Identities = 47/168 (27%), Positives = 85/168 (50%), Gaps = 6/168 (3%)
Query: 1523 WRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFS 1580
W + + IV F+ I+ I L+ + + + +Q +T +L+Y + +F IF
Sbjct: 1144 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1203
Query: 1581 SECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
E LLK A + YF W DF++V S++SLV + + + LR +R
Sbjct: 1204 LEMLLKWVAYGFQTYFTNAWCRLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL--- 1260
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R LR + +G+R ++ AL ++P++ N+ L+ + IF+I G++ F
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1308
Score = 71.3 bits (167), Expect = 3e-11
Identities = 38/117 (32%), Positives = 68/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK L GF + + W WLDF +++++ +V G + A +T
Sbjct: 161 FTGIYTFESLIKILVRGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSALRT 217
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 218 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 70.1 bits (164), Expect = 7e-11
Identities = 51/198 (25%), Positives = 103/198 (52%), Gaps = 22/198 (11%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILMIMP--------TTPTV-ESTEVIFTGIYTFE 180
+R+ I+ H F FI+ IL++ + T T+ E + +FT I+ E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 181 SAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------DLGNLAALRTFRVLR 234
+K +A GF TY +AW LDF+++ ++ V++ +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCRLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+ ++ G CV +
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCVNM-- 1318
Query: 295 EDGSWGNLTDENWERFCQ 312
G+ +++D N CQ
Sbjct: 1319 TTGNMFDISDVNNLSDCQ 1336
Score = 56.8 bits (131), Expect = 7e-07
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 20/166 (12%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MTL + ++ ++Y F I++ E L+KI
Sbjct: 120 IAIKILVHSLFSMLIMCTILTNCVFMTLSN---PPDWTKNVEYT---FTGIYTFESLIKI 173
Query: 1588 ----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
F L F+ +PWN DF V+ V++ + E FVS + +R +V R L
Sbjct: 174 LVRGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGNVSALRTFRVLRAL 224
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 270
>AC108146-1|AAY14794.1| 1146|Homo sapiens unknown protein.
Length = 1146
Score = 412 bits (1014), Expect = e-114
Identities = 218/410 (53%), Positives = 283/410 (69%), Gaps = 34/410 (8%)
Query: 16 FRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPLPV 75
F FT++SL K+ + EKK + E P+P + LE G LP
Sbjct: 12 FVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEA----------PKPSSDLEAGKQLPF 61
Query: 76 RMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAI 135
+ G P + S PLED+DP+Y ++ TF+V++KGK IFRF+AT AL++L PF+P+RR++I
Sbjct: 62 -IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQP 194
ILVH LFS+ I+ TIL NCI M M P ++ E FTGIYTFES VK++ARGF +
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180
Query: 195 FTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
FT+LRD WNWLDFVVI AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+
Sbjct: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNE 314
SVK L DV+ILT+F LSVFAL+GLQ++MG L KC + E+ N T E+ ++E
Sbjct: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN----NETLESIMNTLESE 296
Query: 315 TN-----WYGEGG-DYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
+ +Y EG D LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ F
Sbjct: 297 EDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALF 355
Query: 369 RLMTQDYWENLYQ-----------LFFVVIIFLGSFYLVNLILAIVAMSY 407
RLMTQDYWENLYQ +FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405
Score = 177 bits (432), Expect = 2e-43
Identities = 94/208 (45%), Positives = 125/208 (60%), Gaps = 10/208 (4%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRT 855
F L +TL +V LF+A D + L+S LRVFKLAKSWPTLN+LI I+G +
Sbjct: 800 FDSLIVTLSLV--ELFLA------DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 851
Query: 856 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDG-DLPRWNFTDFMHSFMIVFR 914
+GALGNLT VL II+FIFAV+GMQLFGK+Y + V + D LPRW+ DF HSF+IVFR
Sbjct: 852 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFR 911
Query: 915 VLCGEWIESMWDCM-LVGDVSCIPFFLATVVIXXXXXXXXXXXXXXXXXXXXXXXTPTAD 973
VLCGEWIE+MWDCM + G C+ ++ +VI D
Sbjct: 912 VLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEED 971
Query: 974 QDTNKIAEAFNRISRFIDWIKRNVADFL 1001
D N + A RI + I+++K+ + +F+
Sbjct: 972 PDANNLQIAVTRIKKGINYVKQTLREFI 999
Score = 98.7 bits (235), Expect = 2e-19
Identities = 80/271 (29%), Positives = 138/271 (50%), Gaps = 36/271 (13%)
Query: 1521 PRW-RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIF 1579
P W + + ++ IV D D+ I + I LN L M ++H+ +E F VL N++F IF
Sbjct: 717 PYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1580 SSECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKV 1638
++E +LK+ A+ Y YF WN+FD ++V S++ L L+D+ L V+R ++
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV--------EGLSVLRSFRL 828
Query: 1639 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--------MHV 1690
RV +L K + L+ + S+ AL N+ L+L +++FIFA+ GM F +
Sbjct: 829 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 888
Query: 1691 KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSA 1750
D L ++ F S +++F+ VL G E D + G A
Sbjct: 889 NDDCTLPR-WHMNDFFHSFLIVFR---------VLCGEWIETMWDCME-------VAGQA 931
Query: 1751 TIGITYLLSYLVISFLIVINMYIAVILENYS 1781
I Y++ +VI L+V+N+++A++L ++S
Sbjct: 932 MCLIVYMM-VMVIGNLVVLNLFLALLLSSFS 961
Score = 79.8 bits (188), Expect = 9e-14
Identities = 50/193 (25%), Positives = 99/193 (51%), Gaps = 14/193 (7%)
Query: 113 FRFSATNALWILDPF-NPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE- 170
+RF+ +W P+ ++ +I++ P L I I++N + M M P E +
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
Query: 171 ------VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN 223
++FTGI+ E +K++A + P+ Y + WN D +++ L+ V + + D+
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ LR+FR+LR K P L ++ + SV L ++ ++ + +FA++G+Q++ G
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878
Query: 284 VLTQKCVKVFPED 296
++CV +D
Sbjct: 879 KSYKECVCKINDD 891
Score = 78.6 bits (185), Expect = 2e-13
Identities = 45/174 (25%), Positives = 90/174 (51%), Gaps = 7/174 (4%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W + + ++ + + + A+ I+L++L +A+E H P +++L + +FT IF
Sbjct: 719 WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME--HHPMTEEFKNVLAIGNLVFTGIF 776
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
EM++K +A+ +YF W D +IV +SL+ A ++ +R+ R LR
Sbjct: 777 AAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA-----DVEGLSVLRSFRLLRV 831
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
+ + +++ + ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 885
Score = 75.4 bits (177), Expect = 2e-12
Identities = 29/60 (48%), Positives = 43/60 (71%)
Query: 772 FCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
F +W+C W++F+K + +V DPFV+L IT+CIV+NTLFMA++HH M ++ L GN
Sbjct: 710 FLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN 769
Score = 73.3 bits (172), Expect = 8e-12
Identities = 46/175 (26%), Positives = 92/175 (52%), Gaps = 19/175 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + K++ ++ F ++ IL + + + + + D ++ FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP--------PDWTKNVEYTFTGIYTFE 166
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
L+K LA GF + + W WLDF++++ + ++ G + A +T R LRAL+
Sbjct: 167 SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSALRTFRVLRALK 223
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY-FKC 1376
+ S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G KC
Sbjct: 224 TI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC 275
Score = 61.3 bits (142), Expect = 3e-08
Identities = 50/188 (26%), Positives = 94/188 (50%), Gaps = 21/188 (11%)
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
I +I+ F M+IM I N + MT+++ ++ ++Y F I++ E L+KI
Sbjct: 118 ISIKILVHSLFSMLIMCTILTNCIFMTMNN---PPDWTKNVEYT---FTGIYTFESLVKI 171
Query: 1588 FAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
A + + +PWN DFVV++F+ L+ FV+ + +R +V R L
Sbjct: 172 LARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGNVSALRTFRVLRAL 222
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM-HVKDKGGLDDVYN 1701
+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM ++K K + + N
Sbjct: 223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN 282
Query: 1702 FKTFVQSM 1709
+T M
Sbjct: 283 NETLESIM 290
>L29385-1|AAA59205.1| 2270|Homo sapiens voltage-dependent calcium
channel alpha-1E-3 protein.
Length = 2270
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>L29384-1|AAA59204.1| 2251|Homo sapiens voltage-dependent calcium
channel alpha-1E-1 protein.
Length = 2251
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1130 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1188
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1189 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1248
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1249 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1308
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1309 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1423
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1424 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1483
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1484 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1543
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1544 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1600
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1601 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1660
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1661 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1717
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1718 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1777
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1778 VAEDMTVHFTSTLMALIR 1795
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1112 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1171
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1172 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1231
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1232 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1291
Query: 281 YMG 283
+ G
Sbjct: 1292 FKG 1294
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1454 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1513
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1514 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1569
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1570 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1610
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1556 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1615
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1616 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1661
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>L27745-1|AAA72125.1| 2312|Homo sapiens voltage-operated calcium
channel, alpha-1 subunit protein.
Length = 2312
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1148 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1206
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1207 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1266
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1267 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1326
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1327 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1386
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1387 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1441
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1442 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1501
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1502 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1561
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1562 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1618
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1619 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1678
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1679 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1735
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1736 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1795
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1796 VAEDMTVHFTSTLMALIR 1813
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1130 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1189
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1190 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1249
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1250 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1309
Query: 281 YMG 283
+ G
Sbjct: 1310 FKG 1312
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIITVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 87.4 bits (207), Expect = 5e-16
Identities = 65/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF ++I
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAII 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 66.5 bits (155), Expect = 9e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + + VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIITVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1472 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1531
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1532 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1587
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1588 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1628
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1574 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1633
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1634 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1679
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL590998-3|CAI22327.1| 2270|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2270
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL590998-2|CAI22329.1| 2313|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2313
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL590998-1|CAI22328.1| 2251|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2251
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1130 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1188
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1189 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1248
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1249 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1308
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1309 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1423
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1424 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1483
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1484 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1543
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1544 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1600
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1601 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1660
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1661 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1717
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1718 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1777
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1778 VAEDMTVHFTSTLMALIR 1795
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1112 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1171
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1172 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1231
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1232 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1291
Query: 281 YMG 283
+ G
Sbjct: 1292 FKG 1294
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1454 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1513
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1514 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1569
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1570 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1610
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1556 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1615
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1616 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1661
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL359270-3|CAI14653.1| 2270|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2270
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL359270-2|CAI14655.1| 2313|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2313
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL359270-1|CAI14654.1| 2251|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2251
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1130 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1188
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1189 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1248
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1249 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1308
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1309 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1423
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1424 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1483
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1484 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1543
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1544 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1600
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1601 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1660
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1661 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1717
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1718 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1777
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1778 VAEDMTVHFTSTLMALIR 1795
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1112 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1171
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1172 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1231
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1232 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1291
Query: 281 YMG 283
+ G
Sbjct: 1292 FKG 1294
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1454 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1513
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1514 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1569
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1570 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1610
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1556 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1615
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1616 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1661
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL161734-3|CAH72676.1| 2313|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2313
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL161734-2|CAH72677.1| 2251|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2251
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1130 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1188
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1189 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1248
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1249 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1308
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1309 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1423
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1424 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1483
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1484 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1543
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1544 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1600
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1601 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1660
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1661 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1717
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1718 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1777
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1778 VAEDMTVHFTSTLMALIR 1795
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1112 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1171
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1172 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1231
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1232 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1291
Query: 281 YMG 283
+ G
Sbjct: 1292 FKG 1294
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1454 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1513
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1514 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1569
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1570 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1610
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1556 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1615
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1616 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1661
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL161734-1|CAH72675.1| 2270|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2270
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL160059-3|CAI17083.1| 2270|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2270
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL160059-2|CAI17082.1| 2313|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2313
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1207
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1328 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1387
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1388 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1442
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1443 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1502
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1503 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1562
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1563 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1679
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1680 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1736
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1737 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1796
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1797 VAEDMTVHFTSTLMALIR 1814
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1131 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1190
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 281 YMG 283
+ G
Sbjct: 1311 FKG 1313
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1473 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1533 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1588
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1589 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1575 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1634
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1635 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1680
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AL160059-1|CAI17081.1| 2251|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit protein.
Length = 2251
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1130 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1188
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1189 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1248
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1249 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1308
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1309 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1368
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1369 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1423
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1424 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1483
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1484 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1543
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1544 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1600
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1601 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1660
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1661 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1717
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1718 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1777
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1778 VAEDMTVHFTSTLMALIR 1795
Score = 134 bits (324), Expect = 3e-30
Identities = 95/316 (30%), Positives = 159/316 (50%), Gaps = 53/316 (16%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L+I N +R+ A ++ P F I+ TI+ NCI++ + P +
Sbjct: 63 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSR 122
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLG- 222
+E TE F GI+ FE+ +K++A GFI +YLR+ WN +DF+V+ + T G
Sbjct: 123 RLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT 182
Query: 223 --NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query: 281 YMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGY 340
Y G L + C F N + EG D P + G C GY
Sbjct: 243 YSGKLHRAC--------------------FMNN--SGILEGFDPP---HPCGVQGCPAGY 277
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVII 388
C GPN G T FD +A L+ F+ +T + W LY L+F+ +I
Sbjct: 278 ECKDWIGPND--GITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLI 335
Query: 389 FLGSFYLVNLILAIVA 404
+GSF+++NL+L +++
Sbjct: 336 IIGSFFVLNLVLGVLS 351
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1112 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1171
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1172 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1231
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1232 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1291
Query: 281 YMG 283
+ G
Sbjct: 1292 FKG 1294
Score = 89.0 bits (211), Expect = 1e-16
Identities = 75/289 (25%), Positives = 137/289 (47%), Gaps = 27/289 (9%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
KLI+ FE ++ I+ + + LALE HLP + + L + F IF E IK
Sbjct: 84 KLIDWPPFEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 1271 WLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DFI+V+ ++ A +T+R +R LRPL+
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKL 200
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+S + +++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ +
Sbjct: 201 VSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 1387 EIIPDK----NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
P C E W + FD++ A L +FQ T +GW ++ + D
Sbjct: 261 GFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTND 320
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +G + +LY LNL +GV+ F +++++
Sbjct: 321 A--LGA-------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 360
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 465 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 522
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 523 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 582
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 583 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 629
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 630 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 672
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 673 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 729
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 730 QKAKEVSPMSAPNMP 744
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 472 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 531
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 532 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 588
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 648
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 649 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 696
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 697 VFLAIAVDNLANAQELTKDEQE 718
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 571 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 629
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 630 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 665
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 205
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 206 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1454 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1513
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1514 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1569
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1570 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1610
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1556 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1615
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1616 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1661
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 512 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 568 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 283 G 283
G
Sbjct: 627 G 627
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 166 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 224
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 225 GLLLFFAILMFAIIGLEFY 243
>AF223391-1|AAF37687.1| 2224|Homo sapiens calcium channel alpha1E
subunit, delta39 splice variant protein.
Length = 2224
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1060 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1118
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1119 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1178
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1179 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1238
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1239 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1298
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1299 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1353
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1354 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1413
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1414 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1473
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1474 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1530
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1531 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1590
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1591 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1647
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1648 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1707
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1708 VAEDMTVHFTSTLMALIR 1725
Score = 124 bits (298), Expect = 4e-27
Identities = 88/288 (30%), Positives = 145/288 (50%), Gaps = 53/288 (18%)
Query: 143 FSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
F I+ TI+ NCI++ + P + +E TE F GI+ FE+ +K++A GFI
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 193 QPFTYLRDAWNWLDFVVIALAYV-TMGIDLG---NLAALRTFRVLRALKTVAIVPGLKTI 248
+YLR+ WN +DF+V+ + T G +L LR RVLR LK V+ +P L+ +
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIV 121
Query: 249 VGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWE 308
+ ++++++ L + +L F++ +FA++GL+ Y G L + C
Sbjct: 122 LKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------------------- 162
Query: 309 RFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
F N + EG D P + G C GY C GPN G T FD +A L+ F
Sbjct: 163 -FMNN--SGILEGFDPP---HPCGVQGCPAGYECKDWIGPND--GITQFDNILFAVLTVF 214
Query: 369 RLMTQDYWEN-LYQ-----------LFFVVIIFLGSFYLVNLILAIVA 404
+ +T + W LY L+F+ +I +GSF+++NL+L +++
Sbjct: 215 QCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 262
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1042 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1101
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1102 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1161
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1162 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1221
Query: 281 YMG 283
+ G
Sbjct: 1222 FKG 1224
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 376 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 433
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 434 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 493
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 494 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 540
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 541 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 583
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 584 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 640
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 641 QKAKEVSPMSAPNMP 655
Score = 86.2 bits (204), Expect = 1e-15
Identities = 72/282 (25%), Positives = 133/282 (47%), Gaps = 27/282 (9%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGF- 1276
FE ++ I+ + + LALE HLP + + L + F IF E IK +ALGF
Sbjct: 2 FEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFI 60
Query: 1277 ---QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DFI+V+ ++ A +T+R +R LRPL+ +S + +
Sbjct: 61 FHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSL 118
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK- 1392
++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ + P
Sbjct: 119 QIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHP 178
Query: 1393 ---NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQ 1444
C E W + FD++ A L +FQ T +GW ++ + D+ +G
Sbjct: 179 CGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA--LGA- 235
Query: 1445 PIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +LY LNL +GV+ F +++++
Sbjct: 236 ------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 271
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 383 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 442
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 443 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 499
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 500 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 559
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 560 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 607
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 608 VFLAIAVDNLANAQELTKDEQE 629
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 482 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 540
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 541 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 576
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 116
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 117 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 154
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1384 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1443
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1444 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1499
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1500 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1540
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1486 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1545
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1546 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1591
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 423 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 478
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 479 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 537
Query: 283 G 283
G
Sbjct: 538 G 538
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 77 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 135
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 136 GLLLFFAILMFAIIGLEFY 154
>AB209499-1|BAD92736.1| 1869|Homo sapiens calcium channel,
voltage-dependent, alpha 1E subunit variant protein.
Length = 1869
Score = 329 bits (808), Expect = 7e-89
Identities = 203/678 (29%), Positives = 357/678 (52%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 748 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 806
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 807 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 866
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 867 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 926
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 927 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 986
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 987 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1041
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1042 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1101
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1102 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1161
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1162 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1218
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1219 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1278
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1279 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1335
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIP 1846
D + +W +D I Y ++ + L ++ PPL + K P+K YK ++ M++P
Sbjct: 1336 GPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMP 1395
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1396 VAEDMTVHFTSTLMALIR 1413
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 730 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 789
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 790 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 849
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 850 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 909
Query: 281 YMG 283
+ G
Sbjct: 910 FKG 912
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 64 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 121
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 122 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 181
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 182 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 228
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 229 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 271
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 272 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 328
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 329 QKAKEVSPMSAPNMP 343
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 71 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 130
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 131 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 187
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 188 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 247
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 248 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 295
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 296 VFLAIAVDNLANAQELTKDEQE 317
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 170 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 228
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 229 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 264
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1072 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1131
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1132 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1187
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1188 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1228
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1174 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1233
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1234 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1279
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 111 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 166
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 167 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 225
Query: 283 G 283
G
Sbjct: 226 G 226
>AB037525-1|BAA90445.1| 364|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 364
Score = 328 bits (805), Expect = 2e-88
Identities = 157/292 (53%), Positives = 217/292 (74%), Gaps = 7/292 (2%)
Query: 1626 SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMS 1685
SPTL RV+R+A++GR+LRL+KGAKGIRTLLFAL MSLPALFNI LLLFLVMFIF+IFGMS
Sbjct: 1 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMS 60
Query: 1686 FFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE-EECDLPDNERGS- 1743
F +VK + G+DD++NF+TF SMI LFQ++TSAGWDG+L I+N +C L GS
Sbjct: 61 NFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSG 120
Query: 1744 -PGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEI 1802
G+CG+ ++GI + +SY++ISFLIV+NMYIA+ILEN+S ATE+ + L++DD++ +YEI
Sbjct: 121 FKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEI 180
Query: 1803 WQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDAL 1862
W++FDPD +Q+I Y +L+DF D LE PL++ KPN ++I+MD+P+ GD + C+DIL A
Sbjct: 181 WEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAF 240
Query: 1863 TKDFFARKGNPIEETGDLE----VGRPEEAGYEPVSSTLWRQREEYCARLIQ 1910
TK G +E P + YEP+++TL R++EE A ++Q
Sbjct: 241 TKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ 292
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/208 (23%), Positives = 93/208 (44%), Gaps = 40/208 (19%)
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
F+ +R R R LR + +G+R ++ AL+ ++P++FN+ L+ + IF+I G+ FA
Sbjct: 5 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA- 63
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGW--- 1428
Y K HE D NF+ G + +CLFQ+ T GW
Sbjct: 64 -YVK----------HEAGID-------------DMFNFETFGNSMICLFQITTSAGWDGL 99
Query: 1429 -IQIMND----AIDSREVG---RQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
+ I+N ++D G + ++ ++ + +N++I +I++NF
Sbjct: 100 LLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFF-VSYIIISFLIVVNMYIAIILENF 158
Query: 1481 NEQKKKAGGSLEMFMTEDQKKYYNAMKK 1508
+ +++ L +D + +Y +K
Sbjct: 159 SVATEESADPLS---EDDFETFYEIWEK 183
Score = 36.7 bits (81), Expect = 0.84
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 9/86 (10%)
Query: 830 GNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYV 889
G LR+ K AK TL L ++M ++ AL N+ +L +++FIF++ GM F YV +
Sbjct: 14 GRILRLIKGAKGIRTL--LFALM-MSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHE 68
Query: 890 DRFPDGDLPRWNFTDFMHSFMIVFRV 915
D +NF F +S + +F++
Sbjct: 69 AGIDD----MFNFETFGNSMICLFQI 90
>Z34812-1|CAA84343.1| 2146|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2146
Score = 326 bits (800), Expect = 6e-88
Identities = 204/670 (30%), Positives = 361/670 (53%), Gaps = 35/670 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++++ S + R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1676 MFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEE 1733
FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1734 C---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
C P N CGS + + Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 1420 CAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSI 1477
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++SM++
Sbjct: 1478 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNM 1537
Query: 1846 PI-CRGDMMF 1854
P+ G +MF
Sbjct: 1538 PLNSDGTVMF 1547
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/162 (24%), Positives = 81/162 (50%), Gaps = 20/162 (12%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRTFRVLRALKTV 239
+P Y DAWN D +++ + V + I ++ N + R FRV+R +K +
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLL 1329
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1371
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1323 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1382
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1383 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1415
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>L29529-1|AAA51899.1| 2169|Homo sapiens L-type voltage-dependent
cardiac calcium channel alpha 1 subunit protein.
Length = 2169
Score = 326 bits (800), Expect = 6e-88
Identities = 204/670 (30%), Positives = 361/670 (53%), Gaps = 35/670 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 861 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 919
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 920 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 976
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 977 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1036
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1037 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1096
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1097 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1156
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1157 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1210
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1211 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1270
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++++ S + R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++
Sbjct: 1271 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1330
Query: 1676 MFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEE 1733
FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++
Sbjct: 1331 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1390
Query: 1734 C---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
C P N CGS + + Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 1391 CAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSI 1448
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++SM++
Sbjct: 1449 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNM 1508
Query: 1846 PI-CRGDMMF 1854
P+ G +MF
Sbjct: 1509 PLNSDGTVMF 1518
Score = 134 bits (323), Expect = 4e-30
Identities = 95/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 74 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 133
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 134 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 193
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 194 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 253
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 254 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 294
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL-- 382
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 295 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW 353
Query: 383 -FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 354 VYFVSLVIFGSFFVLNLVLGVLS 376
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 608
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 609 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 665
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 666 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 713
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 714 ILLNVFLAIAVDNLADA 730
Score = 95.9 bits (228), Expect = 1e-18
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 84 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 143
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 144 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 203
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 204 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 263
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 264 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 323
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ +G + ++Y LNL +GV
Sbjct: 324 MLTVFQCITMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLGV 374
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 375 LSGEFSKEREKA 386
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 474 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 531
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 532 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 591
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 592 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 649
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 650 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 687
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 688 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 743
Query: 1497 EDQKK 1501
+++KK
Sbjct: 744 KERKK 748
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 908 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 967
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 968 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1026
Score = 73.3 bits (172), Expect = 8e-12
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 50 TQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 109
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 110 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 169
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 170 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 229
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 230 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 262
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 590 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 648
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 649 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 702
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/162 (24%), Positives = 81/162 (50%), Gaps = 20/162 (12%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1185 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1243
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRTFRVLRALKTV 239
+P Y DAWN D +++ + V + I ++ N + R FRV+R +K +
Sbjct: 1244 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLL 1300
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1301 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1342
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1294 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1353
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1354 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1386
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 587 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 646
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 205 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 264
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 265 MHKTCYNQEGIADVP 279
>AY830711-1|AAX37354.1| 2144|Homo sapiens voltage-dependent L-type
calcium channel alpha-1C subunit splice variant protein.
Length = 2144
Score = 325 bits (798), Expect = 1e-87
Identities = 207/671 (30%), Positives = 363/671 (54%), Gaps = 39/671 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDIIEKYF-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFL 1674
+++ E+ +S T R+ RV R+++L+ +GIRTLL+ S AL + LL+ +
Sbjct: 1300 ITENAEENSRISITFFRLFRVM---RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1356
Query: 1675 VMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
+ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W ++ + +
Sbjct: 1357 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1416
Query: 1733 EC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+C P N CGS + + Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 1417 KCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WS 1474
Query: 1790 GLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMD 1844
L D + IW +DP+ I++ + L ++PPL K P++ +++SM+
Sbjct: 1475 ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMN 1534
Query: 1845 IPI-CRGDMMF 1854
+P+ G +MF
Sbjct: 1535 MPLNSDGTVMF 1545
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.8 bits (131), Expect = 7e-07
Identities = 39/160 (24%), Positives = 79/160 (49%), Gaps = 18/160 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLG-------NLAALRTFRVLRALKTVAI 241
+P Y DAWN D +++ + V + I ++ R FRV+R +K ++
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSR 1329
Query: 242 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1369
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1321 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1380
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1381 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1413
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34816-1|CAA84347.1| 2138|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2138
Score = 324 bits (795), Expect = 3e-87
Identities = 209/681 (30%), Positives = 367/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1273 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>L29536-1|AAA51901.1| 2109|Homo sapiens calcium channel L-type alpha 1
subunit protein.
Length = 2109
Score = 324 bits (795), Expect = 3e-87
Identities = 209/681 (30%), Positives = 367/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 861 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 919
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 920 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 976
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 977 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1036
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1037 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1096
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1097 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1156
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1157 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1210
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1211 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1270
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1271 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1330
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1331 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1390
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1391 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1450 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1508
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1509 VACKRLVSMNMPLNSDGTVMF 1529
Score = 134 bits (323), Expect = 4e-30
Identities = 95/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 74 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 133
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 134 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 193
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 194 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 253
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 254 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 294
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL-- 382
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 295 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW 353
Query: 383 -FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 354 VYFVSLVIFGSFFVLNLVLGVLS 376
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 608
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 609 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 665
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 666 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 713
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 714 ILLNVFLAIAVDNLADA 730
Score = 95.9 bits (228), Expect = 1e-18
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 84 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 143
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 144 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 203
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 204 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 263
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 264 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 323
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ +G + ++Y LNL +GV
Sbjct: 324 MLTVFQCITMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLGV 374
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 375 LSGEFSKEREKA 386
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 474 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 531
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 532 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 591
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 592 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 649
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 650 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 687
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 688 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 743
Query: 1497 EDQKK 1501
+++KK
Sbjct: 744 KERKK 748
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 908 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 967
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 968 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1026
Score = 73.3 bits (172), Expect = 8e-12
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 50 TQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 109
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 110 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 169
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 170 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 229
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 230 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 262
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 590 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 648
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 649 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 702
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1185 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1243
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1244 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1300
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1301 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1353
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1364
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1365 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1397
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 587 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 646
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 205 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 264
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 265 MHKTCYNQEGIADVP 279
>L29534-1|AAA51900.1| 2144|Homo sapiens cardiac L-type
voltage-dependent calcium channel a1 subunit protein.
Length = 2144
Score = 324 bits (795), Expect = 3e-87
Identities = 209/681 (30%), Positives = 367/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 861 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 919
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 920 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 976
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 977 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1036
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1037 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1096
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1097 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1156
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1157 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1210
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1211 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1270
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1271 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1330
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1331 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1390
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1391 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1450 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1508
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1509 VACKRLVSMNMPLNSDGTVMF 1529
Score = 134 bits (323), Expect = 4e-30
Identities = 95/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 74 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 133
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 134 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 193
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 194 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 253
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 254 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 294
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL-- 382
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 295 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW 353
Query: 383 -FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 354 VYFVSLVIFGSFFVLNLVLGVLS 376
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 608
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 609 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 665
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 666 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 713
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 714 ILLNVFLAIAVDNLADA 730
Score = 95.9 bits (228), Expect = 1e-18
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 84 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 143
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 144 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 203
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 204 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 263
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 264 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 323
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ +G + ++Y LNL +GV
Sbjct: 324 MLTVFQCITMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLGV 374
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 375 LSGEFSKEREKA 386
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 474 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 531
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 532 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 591
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 592 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 649
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 650 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 687
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 688 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 743
Query: 1497 EDQKK 1501
+++KK
Sbjct: 744 KERKK 748
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 908 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 967
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 968 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1026
Score = 73.3 bits (172), Expect = 8e-12
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 50 TQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 109
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 110 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 169
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 170 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 229
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 230 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 262
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 590 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 648
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 649 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 702
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1185 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1243
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1244 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1300
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1301 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1353
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1364
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1365 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1397
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 587 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 646
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 205 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 264
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 265 MHKTCYNQEGIADVP 279
>L04569-1|AAA02501.1| 2180|Homo sapiens L-type voltage-dependent
calcium channel protein.
Length = 2180
Score = 324 bits (795), Expect = 3e-87
Identities = 209/681 (30%), Positives = 367/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 861 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 919
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 920 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 976
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 977 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1036
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1037 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1096
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1097 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1156
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1157 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1210
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1211 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1270
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1271 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1330
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1331 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1390
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1391 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1449
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1450 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1508
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1509 VACKRLVSMNMPLNSDGTVMF 1529
Score = 134 bits (323), Expect = 4e-30
Identities = 95/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 74 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 133
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 134 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 193
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 194 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 253
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 254 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 294
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL-- 382
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 295 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW 353
Query: 383 -FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 354 VYFVSLVIFGSFFVLNLVLGVLS 376
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 492 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 551
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 552 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 608
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 609 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 665
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 666 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 713
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 714 ILLNVFLAIAVDNLADA 730
Score = 95.9 bits (228), Expect = 1e-18
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 84 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 143
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 144 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 203
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 204 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 263
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 264 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 323
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ +G + ++Y LNL +GV
Sbjct: 324 MLTVFQCITMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLGV 374
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 375 LSGEFSKEREKA 386
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 474 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 531
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 532 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 591
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 592 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 649
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 650 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 687
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 688 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 743
Query: 1497 EDQKK 1501
+++KK
Sbjct: 744 KERKK 748
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 908 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 967
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 968 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1026
Score = 73.3 bits (172), Expect = 8e-12
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 50 TQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 109
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 110 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 169
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 170 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 229
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 230 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 262
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 590 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 648
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 649 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 702
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1185 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1243
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1244 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1300
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1301 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1353
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1305 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1364
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1365 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1397
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 587 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 646
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 205 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 264
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 265 MHKTCYNQEGIADVP 279
>AY830712-1|AAX37355.1| 2157|Homo sapiens voltage-dependent L-type
calcium channel alpha-1C subunit splice variant protein.
Length = 2157
Score = 324 bits (795), Expect = 3e-87
Identities = 209/681 (30%), Positives = 367/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1273 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>AL358473-3|CAI12387.1| 1854|Homo sapiens calcium channel,
voltage-dependent, L type, alphading protein (CREB) 2
(TORC2) protein.
Length = 1854
Score = 324 bits (795), Expect = 3e-87
Identities = 206/662 (31%), Positives = 356/662 (53%), Gaps = 34/662 (5%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ VV + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF +PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1673
++LS+I + + R+ +V R+++L+ A+G+RTLL+ S AL + LL+
Sbjct: 1197 VILSEIDDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIV 1256
Query: 1674 LVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE 1731
++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W +L
Sbjct: 1257 MLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYG 1316
Query: 1732 EECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
+ CD D G CG+ Y +S+ ++ +VIN+++AVI++N+ T D
Sbjct: 1317 KLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRD-WSI 1374
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++ M++
Sbjct: 1375 LGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNM 1434
Query: 1846 PI 1847
P+
Sbjct: 1435 PL 1436
Score = 122 bits (294), Expect = 1e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C G+ P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSECRGGW-PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 100 bits (239), Expect = 6e-20
Identities = 69/256 (26%), Positives = 133/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IFA+ GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ G P G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM----------AYGGPSYPG--MLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 92.7 bits (220), Expect = 1e-17
Identities = 87/320 (27%), Positives = 145/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYT----W---ENSPMNFD 1410
LF GK YF D+ T + E P CT+ W + +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 87.4 bits (207), Expect = 5e-16
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IFA++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YGGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.9 bits (156), Expect = 7e-10
Identities = 35/95 (36%), Positives = 59/95 (62%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IFA++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 54.8 bits (126), Expect = 3e-06
Identities = 45/172 (26%), Positives = 81/172 (47%), Gaps = 20/172 (11%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P NP + YI+ F + I++N I + M E V FT I+T
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFT 1162
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVI---ALAYVTMGIDLGNLAA------LRT 229
E +K+MA + Y D WN DF+++ + + ID + +A R
Sbjct: 1163 LEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFRL 1218
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1219 FRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF 1270
Score = 44.0 bits (99), Expect = 0.006
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ S++++ +++L + +FAL+G+Q++ G
Sbjct: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
Query: 284 VLTQKCVKV-------FPED--GSWGNLTDENWERFCQNETNWYGEGGDYP 325
+ +V FP+ + LT E+W N YG G YP
Sbjct: 584 RYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-GPSYP 633
Score = 40.7 bits (91), Expect = 0.052
Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 6/132 (4%)
Query: 798 ELFITLCIVVNTLFMALDHHNMDKDMDKAL-KSGNYLRVFKLAKSWPTLNLLISIMGRTM 856
+ I + +++ + +D + + A + +R+ KL + L+ ++
Sbjct: 1186 DFLIVIGSIIDVILSEIDDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSF 1245
Query: 857 GALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVL 916
AL + ++ ++ FI+AV+GMQ+FGK + VD NF F + +++FR
Sbjct: 1246 QALPYVALLIVMLFFIYAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCA 1301
Query: 917 CGE-WIESMWDC 927
GE W E + C
Sbjct: 1302 TGEAWQEILLAC 1313
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>AL139159-2|CAI23206.1| 1854|Homo sapiens calcium channel,
voltage-dependent, L type, alpha protein.
Length = 1854
Score = 324 bits (795), Expect = 3e-87
Identities = 206/662 (31%), Positives = 356/662 (53%), Gaps = 34/662 (5%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ VV + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF +PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1673
++LS+I + + R+ +V R+++L+ A+G+RTLL+ S AL + LL+
Sbjct: 1197 VILSEIDDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIV 1256
Query: 1674 LVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE 1731
++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W +L
Sbjct: 1257 MLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYG 1316
Query: 1732 EECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
+ CD D G CG+ Y +S+ ++ +VIN+++AVI++N+ T D
Sbjct: 1317 KLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRD-WSI 1374
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++ M++
Sbjct: 1375 LGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNM 1434
Query: 1846 PI 1847
P+
Sbjct: 1435 PL 1436
Score = 122 bits (294), Expect = 1e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C G+ P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSECRGGW-PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 100 bits (239), Expect = 6e-20
Identities = 69/256 (26%), Positives = 133/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IFA+ GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ G P G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM----------AYGGPSYPG--MLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 92.7 bits (220), Expect = 1e-17
Identities = 87/320 (27%), Positives = 145/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYT----W---ENSPMNFD 1410
LF GK YF D+ T + E P CT+ W + +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 87.4 bits (207), Expect = 5e-16
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IFA++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YGGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.9 bits (156), Expect = 7e-10
Identities = 35/95 (36%), Positives = 59/95 (62%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IFA++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 54.8 bits (126), Expect = 3e-06
Identities = 45/172 (26%), Positives = 81/172 (47%), Gaps = 20/172 (11%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P NP + YI+ F + I++N I + M E V FT I+T
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFT 1162
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVI---ALAYVTMGIDLGNLAA------LRT 229
E +K+MA + Y D WN DF+++ + + ID + +A R
Sbjct: 1163 LEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDDPDESARISSAFFRL 1218
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1219 FRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF 1270
Score = 44.0 bits (99), Expect = 0.006
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ S++++ +++L + +FAL+G+Q++ G
Sbjct: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
Query: 284 VLTQKCVKV-------FPED--GSWGNLTDENWERFCQNETNWYGEGGDYP 325
+ +V FP+ + LT E+W N YG G YP
Sbjct: 584 RYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-GPSYP 633
Score = 40.7 bits (91), Expect = 0.052
Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 6/132 (4%)
Query: 798 ELFITLCIVVNTLFMALDHHNMDKDMDKAL-KSGNYLRVFKLAKSWPTLNLLISIMGRTM 856
+ I + +++ + +D + + A + +R+ KL + L+ ++
Sbjct: 1186 DFLIVIGSIIDVILSEIDDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSF 1245
Query: 857 GALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVL 916
AL + ++ ++ FI+AV+GMQ+FGK + VD NF F + +++FR
Sbjct: 1246 QALPYVALLIVMLFFIYAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCA 1301
Query: 917 CGE-WIESMWDC 927
GE W E + C
Sbjct: 1302 TGEAWQEILLAC 1313
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>AF223391-2|AAF37688.1| 2162|Homo sapiens calcium channel alpha1E
subunit, delta19 delta40 delta46 splice variant protein.
Length = 2162
Score = 323 bits (793), Expect = 4e-87
Identities = 199/678 (29%), Positives = 352/678 (51%), Gaps = 39/678 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I SS+ALA ED L + +L Y D +FT +F EM+IK +
Sbjct: 1041 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSE-RNKVLRYFDYVFTGVFTFEMVIKMID 1099
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAA-LCGAG---GIQAFKTMRTLRALRPLR 1325
G YF + W LDF++V+ +L+ F A G I+ K++R LR LRPL+
Sbjct: 1100 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1159
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT-- 1383
+ R+ ++ V + +V ++ ++FN+L+V +F IFA++ VQLF GK+F C D + T
Sbjct: 1160 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1219
Query: 1384 --LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ + + +KN ++ W+ ++D++ A L LF V+T +GW Q++ ++D E
Sbjct: 1220 ECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEE 1279
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
R P R + M ++ +N+F+ +II F EQ G M +K
Sbjct: 1280 DRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ-----GDKMMEECSLEKN 1334
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q V+ V F+ IM I LN + + + +Y
Sbjct: 1335 ERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA 1394
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSD- 1618
T+ L YLN+ F ++FS EC+LK+ A + +YF + WN+FDF+ V+ SI ++L+D
Sbjct: 1395 PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDS 1454
Query: 1619 -IIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++ + + L++ R A R+++L++ IR LL+ S AL +CLL+ ++ F
Sbjct: 1455 KLVNTSGFNMSFLKLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1511
Query: 1678 IFAIFGMSFFMHVK--DKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I+AI GM F ++K ++ ++ NF++F S++LLF+ +T W ++ + E+ C+
Sbjct: 1512 IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCE 1571
Query: 1736 LPDNERGSPGN----CGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGL 1791
PD S N CG+ + Y +S++ +++N+++AVI++N+ T D L
Sbjct: 1572 -PDTTAPSGQNENERCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD-SSIL 1628
Query: 1792 TDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKI-----ISMDIP 1846
D + +W +D I Y + + V+ PPL + + Y++ + M++P
Sbjct: 1629 GPHHLDEFVRVWAEYDRAACGRIPYKDMYKLVRVISPPLGLGENCPYRVACKRLVLMNMP 1688
Query: 1847 ICRGDMMFCVDILDALTK 1864
+ + L AL +
Sbjct: 1689 VAEDMTVHFTSTLMALIR 1706
Score = 124 bits (298), Expect = 4e-27
Identities = 88/288 (30%), Positives = 145/288 (50%), Gaps = 53/288 (18%)
Query: 143 FSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
F I+ TI+ NCI++ + P + +E TE F GI+ FE+ +K++A GFI
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 193 QPFTYLRDAWNWLDFVVIALAYV-TMGIDLG---NLAALRTFRVLRALKTVAIVPGLKTI 248
+YLR+ WN +DF+V+ + T G +L LR RVLR LK V+ +P L+ +
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIV 121
Query: 249 VGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWE 308
+ ++++++ L + +L F++ +FA++GL+ Y G L + C
Sbjct: 122 LKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------------------- 162
Query: 309 RFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAF 368
F N + EG D P + G C GY C GPN G T FD +A L+ F
Sbjct: 163 -FMNN--SGILEGFDPP---HPCGVQGCPAGYECKDWIGPND--GITQFDNILFAVLTVF 214
Query: 369 RLMTQDYWEN-LYQ-----------LFFVVIIFLGSFYLVNLILAIVA 404
+ +T + W LY L+F+ +I +GSF+++NL+L +++
Sbjct: 215 QCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLS 262
Score = 104 bits (249), Expect = 4e-21
Identities = 61/183 (33%), Positives = 100/183 (54%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--PTTPTVESTEV----- 171
++++I NPIRR YI+ F + I+ I + I + P E +V
Sbjct: 1023 SSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFD 1082
Query: 172 -IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
+FTG++TFE +K++ +G ILQ +Y RD WN LDFVV+ A V G D
Sbjct: 1083 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1142
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ + +FA++ +Q+
Sbjct: 1143 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1202
Query: 281 YMG 283
+ G
Sbjct: 1203 FKG 1205
Score = 89.0 bits (211), Expect = 1e-16
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 35/315 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR+ ++++ F V++++ L++ +A+ VH L +LYY + +F +F +E
Sbjct: 376 LRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLTHLLYYAEFLFLGLFLLE 433
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M +K +G + YF +++ DF + + S+ V A+ G +R LR LR +
Sbjct: 434 MSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKI 493
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 494 TKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF------------- 540
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ NFD A + +FQ+ T + W ++M + I S Q
Sbjct: 541 ------------NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRS-----QGG 583
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ ++ +Y LN+F+ + +DN ++ E +QK +A+
Sbjct: 584 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQK---HAL 640
Query: 1507 KKMGSKKPLKAIPRP 1521
+K P+ A P
Sbjct: 641 QKAKEVSPMSAPNMP 655
Score = 86.2 bits (204), Expect = 1e-15
Identities = 72/282 (25%), Positives = 133/282 (47%), Gaps = 27/282 (9%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGF- 1276
FE ++ I+ + + LALE HLP + + L + F IF E IK +ALGF
Sbjct: 2 FEYMILATIIANCIVLALEQ-HLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFI 60
Query: 1277 ---QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DFI+V+ ++ A +T+R +R LRPL+ +S + +
Sbjct: 61 FHKGSYLRNGWNVMDFIVVLSGIL--ATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSL 118
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK- 1392
++V+ ++++A+ + + L+ L+FAI+G++ ++GK + MN++ + P
Sbjct: 119 QIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHP 178
Query: 1393 ---NACT--LENYTW---ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQ 1444
C E W + FD++ A L +FQ T +GW ++ + D+ +G
Sbjct: 179 CGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDA--LGA- 235
Query: 1445 PIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+ +LY LNL +GV+ F +++++
Sbjct: 236 ------TWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 271
Score = 86.2 bits (204), Expect = 1e-15
Identities = 64/262 (24%), Positives = 123/262 (46%), Gaps = 19/262 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F I++ + LN + + H+ Q + + +L Y +F+ +F E LK++ +
Sbjct: 383 MVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG 442
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V + SI +V + ++LR +R+ R+ ++ K
Sbjct: 443 PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLL---RIFKITKYWAS 499
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 500 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIM 559
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G S Y + + ++N
Sbjct: 560 TVFQILTGEDWNEVMYNGIR------------SQGGVSSGMWSAIYFIVLTLFGNYTLLN 607
Query: 1771 MYIAVILENYSQA---TEDVQE 1789
+++A+ ++N + A T+D QE
Sbjct: 608 VFLAIAVDNLANAQELTKDEQE 629
Score = 68.1 bits (159), Expect = 3e-10
Identities = 41/102 (40%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S+M +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 482 LRALRLLRIFKITKYWASLRNLVVSLMS-SMKSIISLLFLLFLFIVVFALLGMQLFGGRF 540
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F DG P NF F + M VF++L GE W E M++
Sbjct: 541 -----NFNDG-TPSANFDTFPAAIMTVFQILTGEDWNEVMYN 576
Score = 65.7 bits (153), Expect = 2e-09
Identities = 48/158 (30%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHY--QQSET-FSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + + +T S L+ FI IF E +KI AL +
Sbjct: 2 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 61
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DF+VV+ IL+ + +F + LR +R +V R L+LV G
Sbjct: 62 HKGSYLRNGWNVMDFIVVLSGILATAGT-----HFNTHVDLRTLRAVRVLRPLKLVSGIP 116
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +L ++ ++ L I LLLF + +FAI G+ F+
Sbjct: 117 SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 154
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 19/161 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIM-----PTTP--TVESTEVIFTGIYTFESAVKVMAR 188
+ +V P F I+ I +N ++++M P T ++ + FT +++ E +KV+A
Sbjct: 1365 HFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1424
Query: 189 GFILQPFTYLRDAWNWLDFV--------VIALAYVTMGIDLGNLAALRTFRVLRALKTVA 240
GF+ Y RD WN DF+ +I + N++ L+ FR R +K +
Sbjct: 1425 GFL----NYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLR 1480
Query: 241 IVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1481 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1521
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
LK R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +
Sbjct: 1467 LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1526
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIP 937
D + NF F S M++FR GE W E M C+ G+ C P
Sbjct: 1527 DEESHINRHN----NFRSFFGSLMLLFRSATGEAWQEIMLSCL--GEKGCEP 1572
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLG 222
E +F G++ E ++K+ G P Y ++N DF V + A G G
Sbjct: 423 EFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 478
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 479 -ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 537
Query: 283 G 283
G
Sbjct: 538 G 538
Score = 34.7 bits (76), Expect = 3.4
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 803 LCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNL 862
+ ++ L A H N D+ + L++ LR KL P+L +++ + + M L +
Sbjct: 77 IVVLSGILATAGTHFNTHVDL-RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQI 135
Query: 863 TFVLCIIIFIFAVMGMQLF 881
+L I +FA++G++ +
Sbjct: 136 GLLLFFAILMFAIIGLEFY 154
>U79666-1|AAB64179.1| 2505|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 2505
Score = 322 bits (792), Expect = 6e-87
Identities = 207/705 (29%), Positives = 362/705 (51%), Gaps = 43/705 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1291
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1412 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1471
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1472 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1528
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1529 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1586
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 1587 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 1646
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++
Sbjct: 1647 VTE-FGNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1702
Query: 1676 MFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGVL 1725
FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W ++
Sbjct: 1703 FFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIM 1762
Query: 1726 DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1763 LSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTR 1819
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KI 1840
D L D Y +W +DP I Y + L V+ PPL + K P++ ++
Sbjct: 1820 D-SSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRL 1878
Query: 1841 ISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
+ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1879 LRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1923
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1222 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1281
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1282 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1341
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1342 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1401
Score = 100 bits (240), Expect = 5e-20
Identities = 75/311 (24%), Positives = 138/311 (44%), Gaps = 32/311 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 476 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 534 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 593
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 640
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ+ T + W ++M D I S Q
Sbjct: 641 ------------NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGG 683
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ + +Y LN+F+ + +DN ++ E +QK
Sbjct: 684 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKA 743
Query: 1507 KKMGSKKPLKA 1517
K++ PL A
Sbjct: 744 KEVAEVSPLSA 754
Score = 93.9 bits (223), Expect = 5e-18
Identities = 71/271 (26%), Positives = 133/271 (49%), Gaps = 21/271 (7%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 591
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 651
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF +++ +FQ+ T W+ V+ DGI + G G I +++ L
Sbjct: 652 DTFPAAIMTVFQILTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 699
Query: 1762 VISFLIVINMYIAVILENYSQA---TEDVQE 1789
++ + +N+++A+ ++N + A T+D QE
Sbjct: 700 FGNYTL-LNVFLAIAVDNLANAQELTKDEQE 729
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 67.3 bits (157), Expect = 5e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF++L GE W E M+D
Sbjct: 641 -----NFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 676
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 1563 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1622
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 1623 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 1678
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1679 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1714
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1667 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1726
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1727 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1766
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 523 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 579 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 283 G 283
G
Sbjct: 638 G 638
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1329 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1388
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1389 FIFAVVAVQLFKGKFFHCTD 1408
>AB035726-1|BAA94765.1| 2472|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 2472
Score = 322 bits (790), Expect = 1e-86
Identities = 209/705 (29%), Positives = 361/705 (51%), Gaps = 43/705 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1291
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1292 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1351
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1352 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1411
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1412 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1471
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1472 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1528
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1529 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1586
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 1587 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 1646
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++
Sbjct: 1647 VTE-FGNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1702
Query: 1676 MFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGVL 1725
FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W ++
Sbjct: 1703 FFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIM 1762
Query: 1726 DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1763 LSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTR 1819
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK---PN-KYK-I 1840
D L D Y +W +DP I Y + L V+ PPL + K P YK +
Sbjct: 1820 D-SSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVMSPPLGLGKKCPPGVAYKRL 1878
Query: 1841 ISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
+ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1879 LRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1923
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1222 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1281
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1282 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1341
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1342 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1401
Score = 96.7 bits (230), Expect = 7e-19
Identities = 75/311 (24%), Positives = 136/311 (43%), Gaps = 32/311 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 476 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 534 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 593
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 640
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ T + W ++M D I S Q
Sbjct: 641 ------------NFDEGTPPTNFDTFPAARMTVFQSLTGEDWNEVMYDGIKS-----QGG 683
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ + +Y LN+F+ + +DN + E +QK
Sbjct: 684 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANVLELTKDEQEEEEAANQKLALQKA 743
Query: 1507 KKMGSKKPLKA 1517
K++ PL A
Sbjct: 744 KEVAEVSPLSA 754
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 91.1 bits (216), Expect = 4e-17
Identities = 70/271 (25%), Positives = 131/271 (48%), Gaps = 21/271 (7%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 591
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 651
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF + + +FQ T W+ V+ DGI + G G I +++ L
Sbjct: 652 DTFPAARMTVFQSLTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 699
Query: 1762 VISFLIVINMYIAVILENYS---QATEDVQE 1789
++ + +N+++A+ ++N + + T+D QE
Sbjct: 700 FGNYTL-LNVFLAIAVDNLANVLELTKDEQE 729
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 1563 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1622
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 1623 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 1678
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1679 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1714
Score = 64.1 bits (149), Expect = 5e-09
Identities = 40/102 (39%), Positives = 63/102 (61%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF+ L GE W E M+D
Sbjct: 641 -----NFDEG-TPPTNFDTFPAARMTVFQSLTGEDWNEVMYD 676
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1667 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1726
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1727 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1766
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 523 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 579 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 283 G 283
G
Sbjct: 638 G 638
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1329 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1388
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1389 FIFAVVAVQLFKGKFFHCTD 1408
>M94173-1|AAA51898.1| 2237|Homo sapiens N-type calcium channel alpha-1
subunit protein.
Length = 2237
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>M94172-1|AAA51897.1| 2339|Homo sapiens N-type calcium channel alpha-1
subunit protein.
Length = 2339
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AL772363-4|CAI17144.1| 2339|Homo sapiens calcium channel,
voltage-dependent, L type, alphar), member 6 protein.
Length = 2339
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AL772363-1|CAI17141.1| 2237|Homo sapiens calcium channel,
voltage-dependent, L type, alpha7a (RPL7A) protein.
Length = 2237
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AL591424-2|CAI40687.1| 2339|Homo sapiens calcium channel,
voltage-dependent, L type, alphaate 3A protein.
Length = 2339
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AL591424-1|CAI40685.1| 2237|Homo sapiens calcium channel,
voltage-dependent, L type, alpha, alpha protein.
Length = 2237
Score = 320 bits (787), Expect = 2e-86
Identities = 197/657 (29%), Positives = 342/657 (52%), Gaps = 33/657 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIE-K 1622
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I E
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETN 1559
Query: 1623 YFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI
Sbjct: 1560 NFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616
Query: 1683 GMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E
Sbjct: 1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----E 1672
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYY 1800
+ + CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 QANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFI 1730
Query: 1801 EIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1787
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 60.9 bits (141), Expect = 5e-08
Identities = 41/158 (25%), Positives = 79/158 (50%), Gaps = 18/158 (11%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 243
+ Y RDAWN DFV I + + + NL+ LR FR R +K +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583
Query: 244 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1574 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1628
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1629 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1665
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>X99897-1|CAA68172.1| 2262|Homo sapiens calcium channel alpha1 subunit
protein.
Length = 2262
Score = 320 bits (785), Expect = 4e-86
Identities = 207/705 (29%), Positives = 360/705 (51%), Gaps = 43/705 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1234 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1292
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1293 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1352
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1353 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1412
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1413 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTAEGWPQVLKHSVD 1472
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1473 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1529
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1530 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1587
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N+ F +FS EC+LK A +YF + WN+FDFV V+ SI ++
Sbjct: 1588 FYGASVAYENALRVFNIAFTSLFSLECVLKAMAFGILNYFRDAWNIFDFVTVLGSITDIL 1647
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++
Sbjct: 1648 VTE-FGNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1703
Query: 1676 MFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGVL 1725
FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W ++
Sbjct: 1704 FFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIM 1763
Query: 1726 DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1764 LSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTR 1820
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KI 1840
D L D Y +W +DP I Y + L V+ PPL + K P++ ++
Sbjct: 1821 D-SSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRL 1879
Query: 1841 ISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
+ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1880 LRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1924
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1223 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1282
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1283 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1342
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1343 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1402
Score = 100 bits (240), Expect = 5e-20
Identities = 75/311 (24%), Positives = 138/311 (44%), Gaps = 32/311 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 476 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 534 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 593
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 640
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ+ T + W ++M D I S Q
Sbjct: 641 ------------NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGG 683
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ + +Y LN+F+ + +DN ++ E +QK
Sbjct: 684 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKA 743
Query: 1507 KKMGSKKPLKA 1517
K++ PL A
Sbjct: 744 KEVAEVSPLSA 754
Score = 93.9 bits (223), Expect = 5e-18
Identities = 71/271 (26%), Positives = 133/271 (49%), Gaps = 21/271 (7%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 591
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 651
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF +++ +FQ+ T W+ V+ DGI + G G I +++ L
Sbjct: 652 DTFPAAIMTVFQILTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 699
Query: 1762 VISFLIVINMYIAVILENYSQA---TEDVQE 1789
++ + +N+++A+ ++N + A T+D QE
Sbjct: 700 FGNYTL-LNVFLAIAVDNLANAQELTKDEQE 729
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 67.3 bits (157), Expect = 5e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF++L GE W E M+D
Sbjct: 641 -----NFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 676
Score = 61.3 bits (142), Expect = 3e-08
Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ + FT +++ E +K MA G
Sbjct: 1564 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIAFTSLFSLECVLKAMAFGI 1623
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 1624 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 1679
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1680 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1715
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1668 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1727
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1728 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1767
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 523 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 579 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 283 G 283
G
Sbjct: 638 G 638
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1330 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1389
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1390 FIFAVVAVQLFKGKFFHCTD 1409
>DQ363527-1|ABC88010.1| 1088|Homo sapiens low-voltage-activated
calcium channel alpha1H subunit splice variant 513
protein.
Length = 1088
Score = 320 bits (785), Expect = 4e-86
Identities = 180/628 (28%), Positives = 333/628 (53%), Gaps = 36/628 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 25 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 84
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 85 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 144
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 204
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 205 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 259
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF++ ++ E +
Sbjct: 260 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRL 319
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ ++ ++P A P R + + T D+ I I +N++TM+++HY Q
Sbjct: 320 RRLERRRRKAQRRPYYADYSPTRRS---IHSLCTSHYLDLFITFIICVNVITMSMEHYNQ 376
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ + L +I
Sbjct: 377 PKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEI 436
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 437 EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 496
Query: 1678 IFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
I+A G+ F ++ GL F F + + LF++ST W+G++ +
Sbjct: 497 IYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL--R 554
Query: 1733 ECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
EC D +C S + Y +++++++ +++N+ +AV++++ ++ ++ +E
Sbjct: 555 ECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE- 607
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
D + D E+ P ++ + D+
Sbjct: 608 --DAELDAEIELEMAQGPGSARRVDADR 633
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 14 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 72
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 73 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 132
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 133 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 192
Query: 281 YMG 283
+ G
Sbjct: 193 FKG 195
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 338 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 397
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 398 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 453
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 454 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 506
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 459 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 516
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 517 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 553
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 353 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 390
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 198
>DQ363526-1|ABC88009.1| 1077|Homo sapiens low-voltage-activated
calcium channel alpha1H subunit splice variant 512
protein.
Length = 1077
Score = 320 bits (785), Expect = 4e-86
Identities = 180/628 (28%), Positives = 333/628 (53%), Gaps = 36/628 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 25 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 84
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 85 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 144
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 204
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 205 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 259
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF++ ++ E +
Sbjct: 260 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRL 319
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ ++ ++P A P R + + T D+ I I +N++TM+++HY Q
Sbjct: 320 RRLERRRRKAQRRPYYADYSPTRRS---IHSLCTSHYLDLFITFIICVNVITMSMEHYNQ 376
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ + L +I
Sbjct: 377 PKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEI 436
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 437 EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 496
Query: 1678 IFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
I+A G+ F ++ GL F F + + LF++ST W+G++ +
Sbjct: 497 IYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL--R 554
Query: 1733 ECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
EC D +C S + Y +++++++ +++N+ +AV++++ ++ ++ +E
Sbjct: 555 ECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE- 607
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
D + D E+ P ++ + D+
Sbjct: 608 --DAELDAEIELEMAQGPGSARRVDADR 633
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 14 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 72
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 73 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 132
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 133 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 192
Query: 281 YMG 283
+ G
Sbjct: 193 FKG 195
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 338 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 397
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 398 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 453
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 454 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 506
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 459 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 516
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 517 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 553
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 353 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 390
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 198
>Z34814-1|CAA84345.1| 2127|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2127
Score = 319 bits (784), Expect = 6e-86
Identities = 202/670 (30%), Positives = 360/670 (53%), Gaps = 35/670 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++++ S + R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1676 MFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEE 1733
FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1734 C---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
C P N CGS + + Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 1420 CAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSI 1477
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++SM++
Sbjct: 1478 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNM 1537
Query: 1846 PI-CRGDMMF 1854
P+ G +MF
Sbjct: 1538 PLNSDGTVMF 1547
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/162 (24%), Positives = 81/162 (50%), Gaps = 20/162 (12%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRTFRVLRALKTV 239
+P Y DAWN D +++ + V + I ++ N + R FRV+R +K +
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLL 1329
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1371
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1323 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1382
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1383 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1415
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34813-1|CAA84344.1| 2146|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2146
Score = 319 bits (784), Expect = 6e-86
Identities = 202/670 (30%), Positives = 360/670 (53%), Gaps = 35/670 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++++ S + R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1676 MFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEE 1733
FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKK 1419
Query: 1734 C---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
C P N CGS + + Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 1420 CAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSI 1477
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP+ I++ + L ++PPL K P++ +++SM++
Sbjct: 1478 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNM 1537
Query: 1846 PI-CRGDMMF 1854
P+ G +MF
Sbjct: 1538 PLNSDGTVMF 1547
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/162 (24%), Positives = 81/162 (50%), Gaps = 20/162 (12%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGI-DLGN--------LAALRTFRVLRALKTV 239
+P Y DAWN D +++ + V + I ++ N + R FRV+R +K +
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLL 1329
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1371
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1323 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1382
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1383 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1415
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34811-1|CAA84342.1| 2157|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2157
Score = 319 bits (784), Expect = 6e-86
Identities = 206/681 (30%), Positives = 365/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34810-1|CAA84341.1| 2138|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2138
Score = 319 bits (784), Expect = 6e-86
Identities = 206/681 (30%), Positives = 365/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>DQ494460-1|ABF69911.1| 2314|Homo sapiens T calcium channel alpha 1G
subunit variant 157 protein.
Length = 2314
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1557
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1558 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1617
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1618 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1677
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1678 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1737
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1738 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1795
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1845
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1574 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1631
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1749
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1750 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1791
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1792 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1849
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1700 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1757
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1758 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1794
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1582 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631
>DQ494459-1|ABF69910.1| 2266|Homo sapiens T calcium channel alpha 1G
subunit variant 153 protein.
Length = 2266
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1557
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1558 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1617
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1618 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1677
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1678 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1737
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1738 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1795
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1845
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1574 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1631
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1749
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1750 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1791
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1792 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1849
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1700 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1757
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1758 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1794
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1582 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631
>DQ494450-1|ABF69901.1| 2243|Homo sapiens T calcium channel alpha 1G
subunit variant 25 protein.
Length = 2243
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1534
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1535 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1594
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1595 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1654
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1655 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1714
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1715 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1772
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1773 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1551 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1608
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1609 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1668
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1669 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1726
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1727 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1768
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1769 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1826
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1677 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1734
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1735 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1771
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1559 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1608
>AY682083-1|AAT85832.1| 542|Homo sapiens voltage-gated sodium
channel Nav1.6 protein.
Length = 542
Score = 319 bits (784), Expect = 6e-86
Identities = 159/257 (61%), Positives = 194/257 (75%), Gaps = 17/257 (6%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDF VI +AYVT +DLGN++A
Sbjct: 9 KNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSA 68
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 286
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 69 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 287 QKCVK---VFPEDGSWGNLTDENWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGYV 341
KCV F E + +WE + N+TN+Y G + LCGNSS AGQC GY
Sbjct: 129 NKCVVWPINFNESYLENGIKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQ 188
Query: 342 CLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIFL 390
C++ G NPNYGYTSFDTF WAFL+ FRLMTQDYWENLYQL FFV++IF+
Sbjct: 189 CMKA-GRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFV 247
Query: 391 GSFYLVNLILAIVAMSY 407
GSFYLVNLILA+VAM+Y
Sbjct: 248 GSFYLVNLILAVVAMAY 264
Score = 74.1 bits (174), Expect = 5e-12
Identities = 41/124 (33%), Positives = 72/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ +V G + A +T
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YVTEFVDLGNVSALRT 71
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 72 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 1374 FKCV 1377
KCV
Sbjct: 129 NKCV 132
Score = 48.4 bits (110), Expect = 3e-04
Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DF V+M + ++ FV
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVT---------EFVDLGN 65
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 66 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 124
>AL772363-3|CAI17143.1| 2338|Homo sapiens calcium channel,
voltage-dependent, L type, alpha protein.
Length = 2338
Score = 319 bits (784), Expect = 6e-86
Identities = 196/656 (29%), Positives = 341/656 (51%), Gaps = 33/656 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1147 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1205
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1206 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1265
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1266 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1325
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1326 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1385
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1386 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1440
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1441 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1500
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKY 1623
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I
Sbjct: 1501 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANN- 1559
Query: 1624 FVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1683
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI G
Sbjct: 1560 FINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1616
Query: 1684 MSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNER 1741
M F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E+
Sbjct: 1617 MQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----EQ 1672
Query: 1742 GSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYE 1801
+ CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 ANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIR 1730
Query: 1802 IWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1786
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1129 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1188
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1189 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1248
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1249 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1307
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 478 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 535
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 536 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 595
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 596 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 636
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 637 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 685
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 686 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 745
Query: 1513 KPLKA 1517
P+ A
Sbjct: 746 SPMSA 750
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 479 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 538
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 539 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 595
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 596 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 655
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 656 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 703
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 704 VFLAIAVDNLANAQE-----LTKDEEEM 726
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1469 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1528
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + + + NL+ LR FR R +K + +
Sbjct: 1529 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1584
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1585 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1620
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 578 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 636
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 637 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 671
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 512 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 567
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 568 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 626
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 627 LGMQLFGG 634
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1573 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1627
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1628 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1664
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1249 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1305
>AL772363-2|CAI17142.1| 2337|Homo sapiens calcium channel,
voltage-dependent, L type, alpha protein.
Length = 2337
Score = 319 bits (784), Expect = 6e-86
Identities = 196/656 (29%), Positives = 341/656 (51%), Gaps = 33/656 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKY 1623
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANN- 1558
Query: 1624 FVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1683
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI G
Sbjct: 1559 FINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1615
Query: 1684 MSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNER 1741
M F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E+
Sbjct: 1616 MQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----EQ 1671
Query: 1742 GSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYE 1801
+ CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1672 ANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIR 1729
Query: 1802 IWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1730 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1785
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + + + NL+ LR FR R +K + +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1583
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1619
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1572 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1626
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1627 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1663
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AL591424-4|CAI40686.1| 2338|Homo sapiens calcium channel,
voltage-dependent, L type, alpha(TBP)-associated factor,
100kD protein.
Length = 2338
Score = 319 bits (784), Expect = 6e-86
Identities = 196/656 (29%), Positives = 341/656 (51%), Gaps = 33/656 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1147 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1205
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1206 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1265
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1266 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1325
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1326 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1385
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1386 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1440
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1441 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1500
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKY 1623
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I
Sbjct: 1501 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANN- 1559
Query: 1624 FVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1683
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI G
Sbjct: 1560 FINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1616
Query: 1684 MSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNER 1741
M F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E+
Sbjct: 1617 MQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----EQ 1672
Query: 1742 GSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYE 1801
+ CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1673 ANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIR 1730
Query: 1802 IWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1731 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1786
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1129 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1188
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1189 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1248
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1249 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1307
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 478 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 535
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 536 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 595
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 596 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 636
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 637 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 685
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 686 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 745
Query: 1513 KPLKA 1517
P+ A
Sbjct: 746 SPMSA 750
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 479 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 538
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 539 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 595
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 596 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 655
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 656 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 703
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 704 VFLAIAVDNLANAQE-----LTKDEEEM 726
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1469 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1528
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + + + NL+ LR FR R +K + +
Sbjct: 1529 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1584
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1585 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1620
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 578 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 636
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 637 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 671
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 512 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 567
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 568 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 626
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 627 LGMQLFGG 634
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1573 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1627
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1628 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1664
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1249 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1305
>AL591424-3|CAI40688.1| 2337|Homo sapiens calcium channel,
voltage-dependent, L type, alphanit protein.
Length = 2337
Score = 319 bits (784), Expect = 6e-86
Identities = 196/656 (29%), Positives = 341/656 (51%), Gaps = 33/656 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 1146 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 1204
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
LG YF + W LDFI+V +L+ F + I K++R LR LRPL+ + R
Sbjct: 1205 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKR 1264
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLS 1385
+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 1265 LPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRG 1324
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+ + P
Sbjct: 1325 QYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1384
Query: 1446 IRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
+ + ++ +N+F+ +II F EQ K + +K
Sbjct: 1385 SPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1439
Query: 1506 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y +
Sbjct: 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEY 1499
Query: 1565 SAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKY 1623
+L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I
Sbjct: 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANN- 1558
Query: 1624 FVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFG 1683
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI G
Sbjct: 1559 FINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1615
Query: 1684 MSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNER 1741
M F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD E+
Sbjct: 1616 MQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----EQ 1671
Query: 1742 GSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYE 1801
+ CGS Y +S++ + +++N+++AVI++N+ T D L D +
Sbjct: 1672 ANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIR 1729
Query: 1802 IWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 1730 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 1785
Score = 154 bits (373), Expect = 3e-36
Identities = 98/313 (31%), Positives = 167/313 (53%), Gaps = 48/313 (15%)
Query: 115 FSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTP 164
F+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSE 128
Query: 165 TVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGN 223
++ TE F GI+ FE+ +K++A GF+ +YLR+ WN +DFVV+ + T G D +
Sbjct: 129 RLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-D 187
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 188 LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMG 247
Query: 284 VLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCL 343
+ C FP N TD GD+P CG + A CE C
Sbjct: 248 KFHKAC---FP------NSTDAE-------------PVGDFP-CGKEAPARLCEGDTECR 284
Query: 344 QGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LYQ-----------LFFVVIIFLG 391
+ + P PN+G T+FD +A L+ F+ +T + W + LY L+F+ +I +G
Sbjct: 285 E-YWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIG 343
Query: 392 SFYLVNLILAIVA 404
SF+++NL+L +++
Sbjct: 344 SFFMLNLVLGVLS 356
Score = 111 bits (266), Expect = 3e-23
Identities = 58/179 (32%), Positives = 102/179 (56%), Gaps = 14/179 (7%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 1187
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------TMGIDLGNL 224
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V + G D+ +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTI 1247
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1306
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 32/305 (10%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
++++ F V+ ++ L++L +A+ + P R L LY+ + +F +F EM +K
Sbjct: 477 RMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRR--LTTTLYFAEFVFLGLFLTEMSLKMY 534
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
LG + YF +++ DF +++ S+ V A G +R LR LR +
Sbjct: 535 GLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSS 594
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------------- 635
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N+ E NFD A L +FQ+ T + W +M I+S Q ++
Sbjct: 636 ------NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES-----QGGVSKGMF 684
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSK 1512
Y LN+F+ + +DN ++ EM +QK K++
Sbjct: 685 SSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEV 744
Query: 1513 KPLKA 1517
P+ A
Sbjct: 745 SPMSA 749
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 21/268 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
+V + F +++ + LN L + + HY Q + L + +F+ +F +E LK++ L
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG 537
Query: 1592 YH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
YF +N FDF V++ S+ +V + I ++LR +R+ R+ ++ K
Sbjct: 538 PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLL---RIFKVTKYWSS 594
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMI 1710
+R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF TF +++
Sbjct: 595 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAIL 654
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
+FQ+ T W+ V+ I S G Y + + ++N
Sbjct: 655 TVFQILTGEDWNAVMYHGIE------------SQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDM 1798
+++A+ ++N + A E LT D+ +M
Sbjct: 703 VFLAIAVDNLANAQE-----LTKDEEEM 725
Score = 90.6 bits (215), Expect = 5e-17
Identities = 78/285 (27%), Positives = 134/285 (47%), Gaps = 34/285 (11%)
Query: 1220 FETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIKWLALGFQ 1277
FE ++ I+ + + LALE HLP + + + L + F IF E IK +ALGF
Sbjct: 97 FEYMILATIIANCIVLALEQ-HLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFV 155
Query: 1278 ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGM 1333
Y N W +DF++V+ + L AG +T+R +R LRPL+ +S + +
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGI------LATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 1334 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS--HEIIPD 1391
+VV+ ++++A+ + + L+ L+FAI+G++ + GK+ K N T +
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 1392 KNA----CTLENYTWENSP------MNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
K A C + E P NFD++ A L +FQ T +GW I+ + D+
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA--- 326
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
N + +LY LNL +GV+ F +++++
Sbjct: 327 ------AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQ---QSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-- 1592
F+ +I+ I N + + L+ + S LD FI IF E +KI AL +
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1593 ---HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
Y WN+ DFVVV+ IL+ +D LR +R +V R L+LV G
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFD---------LRTLRAVRVLRPLKLVSGIP 207
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + +FAI G+ F+M
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYM 246
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 1527
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + + + NL+ LR FR R +K + +
Sbjct: 1528 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 1583
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1584 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1619
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/101 (36%), Positives = 62/101 (61%), Gaps = 9/101 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 577 LRALRLLRIFKVTKYWSSLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 925
F D + P NF F + + VF++L GE W M+
Sbjct: 636 -----NFQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMY 670
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYV 215
T T+ E +F G++ E ++K+ G P +Y R ++N DF VI A +
Sbjct: 511 TTTLYFAEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAI 566
Query: 216 TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFAL 275
G G ++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL
Sbjct: 567 KPGSSFG-ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 625
Query: 276 MGLQIYMG 283
+G+Q++ G
Sbjct: 626 LGMQLFGG 633
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 1572 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 1626
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 1627 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 1663
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 822 DMD-KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQL 880
D D + L++ LR KL P+L +++ + + M L + +L I +FA++G++
Sbjct: 185 DFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 244
Query: 881 F-GK----NYVDYVDRFPDGDLP 898
+ GK + + D P GD P
Sbjct: 245 YMGKFHKACFPNSTDAEPVGDFP 267
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 1248 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
>AJ420779-1|CAD12646.1| 2347|Homo sapiens calcium channel,
voltage-dependent, T type, alphant regulator of
chromatin, sub protein.
Length = 2347
Score = 319 bits (784), Expect = 6e-86
Identities = 180/628 (28%), Positives = 333/628 (53%), Gaps = 36/628 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 1464 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF++ ++ E +
Sbjct: 1519 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRL 1578
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ ++ ++P A P R + + T D+ I I +N++TM+++HY Q
Sbjct: 1579 RRLERRRREAQRRPYYADYSPTRRS---IHSLCTSHYLDLFITFIICVNVITMSMEHYNQ 1635
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ + L +I
Sbjct: 1636 PKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEI 1695
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1696 EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 1755
Query: 1678 IFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
I+A G+ F ++ GL F F + + LF++ST W+G++ +
Sbjct: 1756 IYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1813
Query: 1733 ECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
EC D +C S + Y +++++++ +++N+ +AV++++ ++ ++ +E
Sbjct: 1814 ECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE- 1866
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
D + D E+ P ++ + D+
Sbjct: 1867 --DAELDAEIELEMAQGPGSARRVDADR 1892
Score = 95.5 bits (227), Expect = 2e-18
Identities = 73/270 (27%), Positives = 132/270 (48%), Gaps = 32/270 (11%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IV K F IM+ I +N L+M +++++Q E + L+ N++F +F+ E LLK+ A
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
Query: 1592 -YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y P+N+FD ++V+ S+ +V + L V+R ++ RVL+LV+
Sbjct: 849 PLGYIRNPYNIFDGIIVVISVWEIVGQ--------ADGGLSVLRTFRLLRVLKLVRFLPA 900
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF---MHVKDKGG--LDDVYNFKTF 1705
+R L L ++ + C LL L +FIF+I GM F +K G + D NF +
Sbjct: 901 LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++ +FQ+ T W+ VL G +++ Y ++ +
Sbjct: 961 LWAIVTVFQILTQEDWNVVLYN-----------------GMASTSSWAALYFVALMTFGN 1003
Query: 1766 LIVINMYIAVILENYSQATEDVQEGLTDDD 1795
++ N+ +A+++E + QA D TD+D
Sbjct: 1004 YVLFNLLVAILVEGF-QAEGDANRSDTDED 1032
Score = 95.1 bits (226), Expect = 2e-18
Identities = 61/166 (36%), Positives = 95/166 (57%), Gaps = 13/166 (7%)
Query: 1213 KLIENTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEML 1268
+L+ N +FE + +I+L+ + L + EDV +IL D F +EM+
Sbjct: 95 RLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFFAVEMV 152
Query: 1269 IKWLALGF--QK-YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
IK +ALG QK Y + W LDF IV+ ++ + +L G + +RT+R LRPLR
Sbjct: 153 IKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEY--SLDGHN--VSLSAIRTVRVLRPLR 208
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
A++R+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
Score = 87.4 bits (207), Expect = 5e-16
Identities = 72/287 (25%), Positives = 132/287 (45%), Gaps = 39/287 (13%)
Query: 1199 PFWQG--WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
P W G W T K +++++ YF ++ IL+++L++ +E P L + L +
Sbjct: 772 PGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEE--LTNALEISN 829
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+FT +F +EML+K LA G Y N + D IIV++S+ V GG+ +T R
Sbjct: 830 IVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--ADGGLSVLRTFR 887
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR L+ +R + ++ VV LV+ + ++ + ++F IF+I+G+ LF K+
Sbjct: 888 LLRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK 944
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T +PD+ NFD + A + +FQ+ T + W ++ + +
Sbjct: 945 TDTGDT------VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGM 984
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
S T+ + LY NL + ++++ F +
Sbjct: 985 AS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 1331
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 1332 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 1391
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 1392 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1451
Query: 281 YMG 283
+ G
Sbjct: 1452 FKG 1454
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/172 (26%), Positives = 88/172 (51%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTF 179
R + ++ +P F + I++NC+ M P +E+ + +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G Q YL D WN LDF ++ + +D N L+A+RT RVLR L+
Sbjct: 150 EMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
Score = 70.5 bits (165), Expect = 6e-11
Identities = 41/147 (27%), Positives = 82/147 (55%), Gaps = 12/147 (8%)
Query: 143 FSLFIITTILVNCILMIMP-------TTPTVESTEVIFTGIYTFESAVKVMARGFILQPF 195
FS I+ ILVN + M + T +E + ++FT ++ E +K++A G P
Sbjct: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850
Query: 196 TYLRDAWNWLDFVVIALA-YVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
Y+R+ +N D +++ ++ + +G G L+ LRTFR+LR LK V +P L+ + +++
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIY 281
++ N+ L M + +F+++G+ ++
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 15/172 (8%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL----DHYQQSETFSAVLDYLNMIFIVIF 1579
RP++ +V + F+ + ML I LN +T+ + + + +L+ + F
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
Query: 1580 SSECLLKIFALRYH----YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
+ E ++K+ AL Y + WN DF +V+ ++ L + + VS + +R VRV
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVSLSAIRTVRV 203
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 204 L---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 883 LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS 942
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 943 LKTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 974
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 10/94 (10%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + N +NFD++G A++ +FQV T +GW+ IM +D+ + Y
Sbjct: 345 NVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFY 394
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++Y +NL + VI F+E K++
Sbjct: 395 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 428
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/78 (28%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIF 389
VC G NP+ G +FD G+A+++ F+++T + W ++ ++F+++I
Sbjct: 346 VCRSG-DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 404
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 405 VGSFFMINLCLVVIATQF 422
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 1718 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 1649
Score = 42.3 bits (95), Expect = 0.017
Identities = 20/77 (25%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
+V + +LD HN+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 179 VVAGMMEYSLDGHNVSLS---AIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 235
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 236 LCFFVFFIFGIVGVQLW 252
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1457
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 405 MSY 407
+
Sbjct: 1016 EGF 1018
Score = 34.3 bits (75), Expect = 4.5
Identities = 15/52 (28%), Positives = 28/52 (53%)
Query: 780 LWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
LW+ F + +V + I + I+VNTL M +++H +++ AL+ N
Sbjct: 778 LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISN 829
Score = 34.3 bits (75), Expect = 4.5
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 633 LLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEA 692
L G GK T + GR+A P A PL R +S L RPLR + T+C D
Sbjct: 1167 LSGEGKGSTDDEAEDGRAAPG-------PRATPLRRAES-LDPRPLRPAALPPTKCRDRD 1218
Query: 693 GKVLKPSSD 701
G+V+ SD
Sbjct: 1219 GQVVALPSD 1227
>AF465484-1|AAM70049.1| 2138|Homo sapiens jejunum L-type calcium
channel alpha1C subunit protein.
Length = 2138
Score = 319 bits (784), Expect = 6e-86
Identities = 206/681 (30%), Positives = 365/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>AF227751-1|AAF37696.1| 2266|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform be protein.
Length = 2266
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1557
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1558 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1617
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1618 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1677
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1678 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1737
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1738 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1795
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1845
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1574 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1631
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1749
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1750 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1791
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1792 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1849
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1700 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1757
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1758 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1794
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1582 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631
>AF126965-1|AAD29400.1| 2243|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit b isoform protein.
Length = 2243
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1534
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1535 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1594
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1595 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1654
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1655 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1714
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1715 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1772
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1773 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1551 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1608
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1609 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1668
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1669 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1726
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1727 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1768
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1769 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1826
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1677 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1734
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1735 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1771
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1559 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1608
>AB032949-1|BAA86437.2| 1717|Homo sapiens KIAA1123 protein protein.
Length = 1717
Score = 319 bits (784), Expect = 6e-86
Identities = 183/597 (30%), Positives = 325/597 (54%), Gaps = 32/597 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 717 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 776
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 777 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 836
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 837 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 894
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 895 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 951
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 952 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1008
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1009 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1068
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1069 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1128
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ F
Sbjct: 1129 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFF 1188
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1189 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1246
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1247 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1296
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1025 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1082
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1083 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1142
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1143 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1200
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1201 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1242
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1243 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1300
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 180 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 239
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 240 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 291
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 292 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 351
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 352 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 380
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 712 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 770
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 771 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 830
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 831 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 890
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 891 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 950
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 951 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1000
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 708 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 766
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 767 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 826
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 827 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 886
Query: 283 G 283
G
Sbjct: 887 G 887
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 189 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 246
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 247 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 304
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 305 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 354
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 355 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 390
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 391 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 422
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 223 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 278
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 279 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 338
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 284 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 343
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 344 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 397
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1151 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1208
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1209 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1245
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 803 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 862
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 863 IGNIVVICCAFFIIFGILGVQLFKGKFFV 891
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 356 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 415
Query: 405 MSY 407
+
Sbjct: 416 EGF 418
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1033 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1082
>DQ494470-1|ABF69921.1| 2366|Homo sapiens T calcium channel alpha 1G
subunit variant 223 protein.
Length = 2366
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>DQ494469-1|ABF69920.1| 2321|Homo sapiens T calcium channel alpha 1G
subunit variant 221 protein.
Length = 2321
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>DQ494468-1|ABF69919.1| 2273|Homo sapiens T calcium channel alpha 1G
subunit variant 217 protein.
Length = 2273
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>DQ494467-1|ABF69918.1| 2194|Homo sapiens T calcium channel alpha 1G
subunit variant 216 protein.
Length = 2194
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>DQ494456-1|ABF69907.1| 2298|Homo sapiens T calcium channel alpha 1G
subunit variant 93 protein.
Length = 2298
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>DQ494455-1|ABF69906.1| 2250|Homo sapiens T calcium channel alpha 1G
subunit variant 89 protein.
Length = 2250
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>DQ494454-1|ABF69905.1| 2171|Homo sapiens T calcium channel alpha 1G
subunit variant 88 protein.
Length = 2171
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>AY682081-1|AAT85830.1| 531|Homo sapiens voltage-gated sodium
channel Nav1.6 protein.
Length = 531
Score = 319 bits (783), Expect = 7e-86
Identities = 160/258 (62%), Positives = 198/258 (76%), Gaps = 19/258 (7%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDF VI +AYVT +DLGN++A
Sbjct: 9 KNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSA 68
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 286
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 69 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 287 QKCVKVFPEDGSWGNLTDE----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGY 340
KCV V+P + + L + +WE + N+TN+Y G + LCGNSS AGQC GY
Sbjct: 129 NKCV-VWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGY 187
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIF 389
C++ G NPNYGYTSFDTF WAFL+ FRLMTQDYWENLYQL FFV++IF
Sbjct: 188 QCMKA-GRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF 246
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSFYLVNLILA+VAM+Y
Sbjct: 247 VGSFYLVNLILAVVAMAY 264
Score = 74.1 bits (174), Expect = 5e-12
Identities = 41/124 (33%), Positives = 72/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ +V G + A +T
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YVTEFVDLGNVSALRT 71
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 72 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 1374 FKCV 1377
KCV
Sbjct: 129 NKCV 132
Score = 48.4 bits (110), Expect = 3e-04
Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DF V+M + ++ FV
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVT---------EFVDLGN 65
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 66 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 124
>AF227746-1|AAF37691.1| 2298|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform af protein.
Length = 2298
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>AF227745-1|AAF37690.1| 2321|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform aef protein.
Length = 2321
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>AF227744-1|AAF37689.1| 2273|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform ae protein.
Length = 2273
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1800 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1850
Query: 1788 QE 1789
+E
Sbjct: 1851 KE 1852
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1756
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1757 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1798
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1799 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1856
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1707 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1764
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1765 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1801
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>AF190860-1|AAF35287.1| 2250|Homo sapiens low voltage-activated T-type
calcium channel alpha 1G splice variant CavT.1a protein.
Length = 2250
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>AF134985-1|AAF19346.1| 2171|Homo sapiens T calcium channel alpha1G
subunit protein.
Length = 2171
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>AF126966-1|AAD29401.1| 2250|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit a isoform protein.
Length = 2250
Score = 319 bits (783), Expect = 7e-86
Identities = 185/602 (30%), Positives = 331/602 (54%), Gaps = 35/602 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1538 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1673 FLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1728 IINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++
Sbjct: 1777 TL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1827
Query: 1788 QE 1789
+E
Sbjct: 1828 KE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>Z34809-1|CAA84340.1| 2138|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2138
Score = 317 bits (779), Expect = 2e-85
Identities = 207/681 (30%), Positives = 366/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
LS+ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 1273 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>AY682082-1|AAT85831.1| 542|Homo sapiens voltage-gated sodium
channel Nav1.6 protein.
Length = 542
Score = 317 bits (778), Expect = 3e-85
Identities = 159/258 (61%), Positives = 198/258 (76%), Gaps = 19/258 (7%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDF VI +AY+T ++LGN++A
Sbjct: 9 KNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSA 68
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 286
LRTFRVLRALKT+++VPGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 69 LRTFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 287 QKCVKVFPEDGSWGNLTDE----NWERFCQNETNWYGEGG--DYPLCGNSSGAGQCEPGY 340
KCV V+P + + L + +WE + N+TN+Y G + LCGNSS AGQC GY
Sbjct: 129 NKCV-VWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGY 187
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQL-----------FFVVIIF 389
C++ G NPNYGYTSFDTF WAFL+ FRLMTQDYWENLYQL FFV++IF
Sbjct: 188 QCMKA-GRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF 246
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSFYLVNLILA+VAM+Y
Sbjct: 247 VGSFYLVNLILAVVAMAY 264
Score = 74.1 bits (174), Expect = 5e-12
Identities = 40/124 (32%), Positives = 72/124 (58%), Gaps = 11/124 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K +A GF + + W WLDF ++M++ ++ G + A
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMA---YITEFVNLGNVSA--- 68
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 69 LRTFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 128
Query: 1374 FKCV 1377
KCV
Sbjct: 129 NKCV 132
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/119 (26%), Positives = 60/119 (50%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DF V+M + ++ FV+
Sbjct: 15 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYIT---------EFVNLGN 65
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 66 VSALRTFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 124
>AB209171-1|BAD92408.1| 1854|Homo sapiens calcium channel,
voltage-dependent, L type, alpha 1D subunit variant
protein.
Length = 1854
Score = 317 bits (778), Expect = 3e-85
Identities = 211/685 (30%), Positives = 360/685 (52%), Gaps = 50/685 (7%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ KLI + F ++ I+LSS ALA ED H IL Y D FT IF +E
Sbjct: 568 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHS-FRNTILGYFDYAFTAIFTVE 626
Query: 1267 MLIKWLALG--FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G K + N + LD ++V VSL++F + I K +R LR LR
Sbjct: 627 ILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQ---SSAISVVKILRVLRVLR 683
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD---M 1379
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK+++C D
Sbjct: 684 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 743
Query: 1380 NHTTLSHEII----PDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
N I D ++ + W+NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 744 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 803
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + + ++ +N+F+G +I F EQ +K + E+
Sbjct: 804 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDK 863
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ + Q + +V F+ ++ + I LN L +
Sbjct: 864 NQRQCVEY-ALK----ARPLRRYIPKNPY--QYKFWYVVNSSPFEYMMFVLIMLNTLCLA 916
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILS 1613
+ HY+QS+ F+ +D LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ S++
Sbjct: 917 MQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVD 976
Query: 1614 LVLSDI--IEKYFVS-PTL------------LRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1658
+ ++++ E V PT + R+ +V R+++L+ +GIRTLL+
Sbjct: 977 IAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1036
Query: 1659 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMS 1716
S AL + LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +
Sbjct: 1037 IKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCA 1096
Query: 1717 TSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAV 1775
T W ++ + + CD D G CGS I Y +S+ ++ ++IN+++AV
Sbjct: 1097 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGS-NFAIVYFISFYMLCAFLIINLFVAV 1155
Query: 1776 ILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK- 1834
I++N+ T D L D + IW +DP+ I++ + L ++PPL K
Sbjct: 1156 IMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKL 1214
Query: 1835 -PNKY---KIISMDIPI-CRGDMMF 1854
P++ ++++M++P+ G +MF
Sbjct: 1215 CPHRVACKRLVAMNMPLNSDGTVMF 1239
Score = 101 bits (241), Expect = 3e-20
Identities = 67/252 (26%), Positives = 129/252 (51%), Gaps = 24/252 (9%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFV 1596
F ++++ + LN LT++ +HY Q + + + D N + + +F+ E L+K+++L YFV
Sbjct: 218 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFV 277
Query: 1597 EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF 1656
+N FD VV I +L +E +SP + V R ++ R+ ++ + + L+
Sbjct: 278 SLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 334
Query: 1657 ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILL 1712
+L S+ ++ ++ LLLFL + IF++ GM F K D+ F F Q+++ +
Sbjct: 335 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDETQTKRSTFDNFPQALLTV 391
Query: 1713 FQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINM 1771
FQ+ T W+ V+ DGI+ G P + G I Y + + I++N+
Sbjct: 392 FQILTGEDWNAVMYDGIM----------AYGGPSSSG--MIVCIYFIILFICGNYILLNV 439
Query: 1772 YIAVILENYSQA 1783
++A+ ++N + A
Sbjct: 440 FLAIAVDNLADA 451
Score = 76.2 bits (179), Expect = 1e-12
Identities = 67/305 (21%), Positives = 134/305 (43%), Gaps = 37/305 (12%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIF 1259
W+ W R + +++ F VI ++ L++L ++ E + P L I +++
Sbjct: 198 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW--LTQIQDIANKVL 255
Query: 1260 TVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA---LCGAGGIQAFKTMR 1316
+F EML+K +LG Q YF + + D +V + + + GI F+ +R
Sbjct: 256 LALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVR 315
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR + R + + + V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 316 LLRIFKVTRHWTSLSNL---VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 369
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ + T + FD+ +A L +FQ+ T + W +M D I
Sbjct: 370 -NFDET--------------------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGI 408
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ + + + +Y LN+F+ + +DN + + E
Sbjct: 409 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 464
Query: 1497 EDQKK 1501
+++KK
Sbjct: 465 KERKK 469
Score = 70.9 bits (166), Expect = 4e-11
Identities = 45/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPTVEST-----E 170
+A +IL NPIR ++ H +F+ I+ I+++ + + + +T +
Sbjct: 557 SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD 616
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTF 230
FT I+T E +K+ G L + R+ +N LD +V+ ++ V+ GI ++ ++
Sbjct: 617 YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKIL 676
Query: 231 RVLRALKTVAIV---PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
RVLR L+ + + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 677 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 732
Score = 61.3 bits (142), Expect = 3e-08
Identities = 31/95 (32%), Positives = 56/95 (58%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG + F
Sbjct: 317 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-----NF 371
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
+ R F +F + + VF++L GE W M+D
Sbjct: 372 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYD 406
Score = 48.4 bits (110), Expect = 3e-04
Identities = 42/187 (22%), Positives = 83/187 (44%), Gaps = 35/187 (18%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P NP + Y++ F + I++N + + M ++ ++FTG++T
Sbjct: 883 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 942
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------- 223
E +KV+A +P Y DAWN D +++ + V + I N
Sbjct: 943 VEMVLKVIA----FKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPG 998
Query: 224 ---------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFA 274
+ R FRV+R +K ++ G++T++ I+S + L V +L ++A
Sbjct: 999 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1058
Query: 275 LMGLQIY 281
++G+Q++
Sbjct: 1059 VIGMQMF 1065
Score = 46.4 bits (105), Expect = 0.001
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 13/78 (16%)
Query: 339 GYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQD------YWEN------LYQLFFVV 386
G C G+ PN G T+FD F +A L+ F+ +T + YW N L ++FV
Sbjct: 3 GTECRSGW-VGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVS 61
Query: 387 IIFLGSFYLVNLILAIVA 404
++ GSF+++NL+L +++
Sbjct: 62 LVIFGSFFVLNLVLGVLS 79
Score = 43.2 bits (97), Expect = 0.010
Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK + ++
Sbjct: 1017 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1076
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W E M C+
Sbjct: 1077 NRNN----NFQTFPQAVLLLFRCATGEAWQEIMLACL 1109
Score = 41.1 bits (92), Expect = 0.039
Identities = 31/118 (26%), Positives = 60/118 (50%), Gaps = 10/118 (8%)
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLGNLAAL--- 227
+ ++T E VK+ + G LQ Y +N D FVV T+ ++L ++ L
Sbjct: 254 VLLALFTCEMLVKMYSLG--LQ--AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGIS 309
Query: 228 --RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R R+LR K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 310 VFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 367
>AB209467-1|BAD92704.1| 1370|Homo sapiens calcium channel,
voltage-dependent, L type, alpha 1B subunit variant
protein.
Length = 1370
Score = 316 bits (777), Expect = 4e-85
Identities = 198/660 (30%), Positives = 345/660 (52%), Gaps = 37/660 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
++ YFE ++ +I LSS+ALA ED P + L Y+D IFT +F EM+IK +
Sbjct: 175 IVTMRYFEVVILVVIALSSIALAAEDPVRTDSP-RNNALKYLDYIFTGVFTFEMVIKMID 233
Query: 1274 LGFQ----KYFTNAWCWLDFIIVMVSLINFVAA--LCGAGG--IQAFKTMRTLRALRPLR 1325
LG YF + W LDFI+V +L+ F + + G+ G I K++R LR LRPL+
Sbjct: 234 LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFVGGSKGKDINTIKSLRVLRVLRPLK 293
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNH 1381
+ R+ ++ V + +V ++ ++ N+L+V ++F IFA++ VQLF GK+F C D +
Sbjct: 294 TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER 353
Query: 1382 TTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREV 1441
+ +K + W+ ++D+V A L LF V+T +GW ++ ++D+
Sbjct: 354 DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 413
Query: 1442 GRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1501
+ P + + ++ +N+F+ +II F EQ K + +K
Sbjct: 414 EQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSL-----EKN 468
Query: 1502 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
+ S KPL + +P+ R Q + V F+ IM I LN + + + Y
Sbjct: 469 ERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDA 528
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ +L LN++F +FS EC+LKI A +YF + WN+FDFV V+ SI +++++I
Sbjct: 529 PYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEI 588
Query: 1620 IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIF 1679
F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+
Sbjct: 589 ANN-FINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 644
Query: 1680 AIFGMSFFMHV--KDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
AI GM F ++ D ++ NF+TF+Q+++LLF+ +T W ++ ++ + CD
Sbjct: 645 AIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD-- 702
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYD 1797
E+ + CGS Y +S++ + +++N+++AVI++N+ T D L D
Sbjct: 703 --EQANATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLD 758
Query: 1798 MYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
+ +W +DP I Y+ + + L + PPL + K P + YK ++ M++PI DM
Sbjct: 759 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDM 818
Score = 107 bits (258), Expect = 3e-22
Identities = 58/183 (31%), Positives = 101/183 (55%), Gaps = 18/183 (9%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM--------PTTPTVESTE 170
++++ L P N +RR YI+ F + I+ I ++ I + P ++ +
Sbjct: 157 SSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLD 216
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM----------GID 220
IFTG++TFE +K++ G +L P Y RD WN LDF+V++ A V G D
Sbjct: 217 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFVGGSKGKD 276
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
+ + +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q+
Sbjct: 277 INTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQL 336
Query: 281 YMG 283
+ G
Sbjct: 337 FKG 339
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP--TTP-----TVESTEVIFTGIYTFESAVKVMARGF 190
+V P F FI+ I +N ++++M P ++ ++FT +++ E +K++A G
Sbjct: 501 VVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGV 560
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + + + NL+ LR FR R +K + +
Sbjct: 561 L----NYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTI 616
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 617 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 652
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D
Sbjct: 605 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD-----D 659
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D + R NF F+ + M++FR GE W E M C+
Sbjct: 660 DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCL 696
Score = 33.5 bits (73), Expect = 7.8
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
K+L+ LR K K P L + + ++ + N+ V + +FIFAV+ +QLF
Sbjct: 281 KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 337
>D43747-1|BAA07804.1| 2170|Homo sapiens voltage-dependent calcium
channel alpha1 subunit, CACN4 protein.
Length = 2170
Score = 315 bits (774), Expect = 9e-85
Identities = 212/683 (31%), Positives = 357/683 (52%), Gaps = 48/683 (7%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ KLI + F ++ I+LSS ALA ED H L Y D FT IF +E
Sbjct: 886 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHS-FRNTTLGYFDYAFTAIFTVE 944
Query: 1267 MLIKWLALG--FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G K + N + LD ++V VSL++F + I K +R LR LR
Sbjct: 945 ILLKMTTFGAFLHKGAFCRNYFNLLDILVVGVSLVSFGIQ---SSAISVVKILRVLRVLR 1001
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD---M 1379
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK+++C D
Sbjct: 1002 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 1061
Query: 1380 NHTTLSHEII----PDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
N I D ++ + W+NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1062 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1121
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + + ++ +N+F+G +I F EQ +K + E+
Sbjct: 1122 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDK 1181
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ + Q + +V F+ ++ + I LN L +
Sbjct: 1182 NQRQCVEY-ALK----ARPLRRYIPKNPY--QYKFWYVVNSSPFEYMMFVLIMLNTLCLA 1234
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILS 1613
+ HY+QS+ F+ +D LNM+F +F+ E +LK+ A + YF + WN FD ++V+ SI+
Sbjct: 1235 MQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIID 1294
Query: 1614 LVLSDIIEKYFVS-PTL------------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1660
+ LS+ E V PT + R+ +V R+++L+ +GIRTLL+
Sbjct: 1295 VALSEPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK 1354
Query: 1661 SLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTS 1718
S AL + LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T
Sbjct: 1355 SFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATG 1414
Query: 1719 AGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W ++ + + CD D G CGS I Y +S+ ++ ++IN+++AVI+
Sbjct: 1415 EAWQEIMLACLPGKLCDPESDYNPGEEYTCGS-NFAIVYFISFYMLCAFLIINLFVAVIM 1473
Query: 1778 ENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--P 1835
+N+ T D L D + IW +DP+ I++ + L ++PPL K P
Sbjct: 1474 DNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP 1532
Query: 1836 NKY---KIISMDIPI-CRGDMMF 1854
++ ++++M++P+ G +MF
Sbjct: 1533 HRVACKRLVAMNMPLNSDGTVMF 1555
Score = 124 bits (300), Expect = 2e-27
Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 63/325 (19%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL+ L NPIRR I I+ F +FI+ I NC+ + + T +E
Sbjct: 96 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 155
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E F I+T E+ +K++A G +L P Y+R+ WN LDFV++ L +T + G
Sbjct: 156 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 215
Query: 223 N----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
N + ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + +
Sbjct: 216 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 275
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C F D ++ E D C S
Sbjct: 276 YAIIGLELFIGKMHKTC---FFAD---SDIVAEE----------------DPAPCAFSGN 313
Query: 333 AGQCEP-GYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY---------- 380
QC G C G+ PN G T+FD F +A L+ F+ +T + W + LY
Sbjct: 314 GRQCTANGTECRSGW-VGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEW 372
Query: 381 -QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 373 PWVYFVSLIILGSFFVLNLVLGVLS 397
Score = 100 bits (240), Expect = 5e-20
Identities = 67/252 (26%), Positives = 128/252 (50%), Gaps = 24/252 (9%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFV 1596
F ++++ + LN LT++ +HY Q + + + D N + + +F+ E L+K++ L YFV
Sbjct: 536 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYTLGLQAYFV 595
Query: 1597 EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF 1656
+N FD VV I +L +E +SP + V R ++ R+ ++ + + L+
Sbjct: 596 SLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 652
Query: 1657 ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILL 1712
+L S+ ++ ++ LLLFL + IF++ GM F K D+ F F Q+++ +
Sbjct: 653 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDETQTKRSTFDNFPQALLTV 709
Query: 1713 FQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINM 1771
FQ+ T W+ V+ DGI+ G P + G I Y + + I++N+
Sbjct: 710 FQILTGEDWNAVMYDGIM----------AYGGPSSSG--MIVCIYFIILFICGNYILLNV 757
Query: 1772 YIAVILENYSQA 1783
++A+ ++N + A
Sbjct: 758 FLAIAVDNLADA 769
Score = 90.2 bits (214), Expect = 6e-17
Identities = 80/311 (25%), Positives = 141/311 (45%), Gaps = 39/311 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E F+ ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 106 IRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTV 165
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALC-----------GAGGIQ 1310
F++++ L L Y N W LDF+IV+V L + + G G
Sbjct: 166 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 225
Query: 1311 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF
Sbjct: 226 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 285
Query: 1371 GKYFK-CVDMNHTTLSHE------IIPDKNACTLENYT----W---ENSPMNFDHVGKAY 1416
GK K C + ++ E + CT W NFD+ A
Sbjct: 286 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 345
Query: 1417 LCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVI 1476
L +FQ T +GW ++ D+ +G + + ++Y LNL +GV+
Sbjct: 346 LTVFQCITMEGWTDVLYWVNDA--IGWE-------WPWVYFVSLIILGSFFVLNLVLGVL 396
Query: 1477 IDNFNEQKKKA 1487
F+++++KA
Sbjct: 397 SGEFSKEREKA 407
Score = 75.8 bits (178), Expect = 1e-12
Identities = 67/305 (21%), Positives = 133/305 (43%), Gaps = 37/305 (12%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIF 1259
W+ W R + +++ F VI ++ L++L ++ E + P L I +++
Sbjct: 516 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW--LTQIQDIANKVL 573
Query: 1260 TVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA---LCGAGGIQAFKTMR 1316
+F EML+K LG Q YF + + D +V + + + GI F+ +R
Sbjct: 574 LALFTCEMLVKMYTLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVR 633
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR + R + + + V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 634 LLRIFKVTRHWTSLSNL---VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 687
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ + T + FD+ +A L +FQ+ T + W +M D I
Sbjct: 688 -NFDET--------------------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGI 726
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ + + + +Y LN+F+ + +DN + + E
Sbjct: 727 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 782
Query: 1497 EDQKK 1501
+++KK
Sbjct: 783 KERKK 787
Score = 72.1 bits (169), Expect = 2e-11
Identities = 45/176 (25%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT--------TPTVESTE 170
+A +IL NPIR ++ H +F+ I+ I+++ + T+ +
Sbjct: 875 SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTTLGYFD 934
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTF 230
FT I+T E +K+ G L + R+ +N LD +V+ ++ V+ GI ++ ++
Sbjct: 935 YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDILVVGVSLVSFGIQSSAISVVKIL 994
Query: 231 RVLRALKTVAIV---PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
RVLR L+ + + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1050
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/173 (28%), Positives = 87/173 (50%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD+ I+L I N + + + S + + L+ + F++IF+ E LKI
Sbjct: 113 IVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKII 172
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DFV+V+ + S++L + ++ ++ +R
Sbjct: 173 AYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRA 232
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G ++ +L ++ ++ L +I LL+ V+ I+AI G+ F+
Sbjct: 233 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 285
Score = 61.3 bits (142), Expect = 3e-08
Identities = 31/95 (32%), Positives = 56/95 (58%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG + F
Sbjct: 635 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-----NF 689
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
+ R F +F + + VF++L GE W M+D
Sbjct: 690 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYD 724
Score = 49.2 bits (112), Expect = 1e-04
Identities = 44/185 (23%), Positives = 86/185 (46%), Gaps = 33/185 (17%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P NP + Y++ F + I++N + + M ++ ++FTG++T
Sbjct: 1201 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1260
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVV-------IALAYVTMGIDL-------GN- 223
E +KV+A +P Y DAWN D ++ +AL+ T ++ GN
Sbjct: 1261 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEPTESENVPVPTATPGNS 1316
Query: 224 -------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALM 276
+ R FRV+R +K ++ G++T++ I+S + L V +L ++A++
Sbjct: 1317 EESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVI 1376
Query: 277 GLQIY 281
G+Q++
Sbjct: 1377 GMQMF 1381
Score = 43.2 bits (97), Expect = 0.010
Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK + ++
Sbjct: 1333 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1392
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W E M C+
Sbjct: 1393 NRNN----NFQTFPQAVLLLFRCATGEAWQEIMLACL 1425
Score = 40.7 bits (91), Expect = 0.052
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLGNLAAL--- 227
+ ++T E VK+ G LQ Y +N D FVV T+ ++L ++ L
Sbjct: 572 VLLALFTCEMLVKMYTLG--LQ--AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGIS 627
Query: 228 --RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R R+LR K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 628 VFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 685
Score = 37.5 bits (83), Expect = 0.48
Identities = 16/57 (28%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF
Sbjct: 228 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 284
>AB035727-1|BAA94766.2| 2506|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 2506
Score = 315 bits (774), Expect = 9e-85
Identities = 207/705 (29%), Positives = 361/705 (51%), Gaps = 43/705 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1232 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1290
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1291 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1350
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1351 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1410
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1411 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1470
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1471 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1527
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1528 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1585
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 1586 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 1645
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ ++
Sbjct: 1646 VTE-FGNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1701
Query: 1676 MFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGVL 1725
FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W ++
Sbjct: 1702 FFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIM 1761
Query: 1726 DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1762 LSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTR 1818
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-I 1840
D L D Y +W +DP + Y + L + PPL + K P + YK +
Sbjct: 1819 D-SSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRL 1877
Query: 1841 ISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
+ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1878 LRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1922
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1221 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1280
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1281 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1340
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1341 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1400
Score = 100 bits (240), Expect = 5e-20
Identities = 75/311 (24%), Positives = 138/311 (44%), Gaps = 32/311 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 475 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 532
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 533 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 592
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 593 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 639
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ+ T + W ++M D I S Q
Sbjct: 640 ------------NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGG 682
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
+ + +Y LN+F+ + +DN ++ E +QK
Sbjct: 683 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKA 742
Query: 1507 KKMGSKKPLKA 1517
K++ PL A
Sbjct: 743 KEVAEVSPLSA 753
Score = 93.9 bits (223), Expect = 5e-18
Identities = 71/271 (26%), Positives = 133/271 (49%), Gaps = 21/271 (7%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 474 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 533
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 534 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 590
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 591 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 650
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF +++ +FQ+ T W+ V+ DGI + G G I +++ L
Sbjct: 651 DTFPAAIMTVFQILTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 698
Query: 1762 VISFLIVINMYIAVILENYSQA---TEDVQE 1789
++ + +N+++A+ ++N + A T+D QE
Sbjct: 699 FGNYTL-LNVFLAIAVDNLANAQELTKDEQE 728
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 67.3 bits (157), Expect = 5e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 581 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 639
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF++L GE W E M+D
Sbjct: 640 -----NFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 675
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 1562 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1621
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 1622 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 1677
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1678 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1713
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1666 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1725
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1726 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1765
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 522 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 577
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 578 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 636
Query: 283 G 283
G
Sbjct: 637 G 637
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1328 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1387
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1388 FIFAVVAVQLFKGKFFHCTD 1407
>DQ363528-1|ABC88011.1| 1083|Homo sapiens low-voltage-activated
calcium channel alpha1H subunit splice variant 544
protein.
Length = 1083
Score = 315 bits (773), Expect = 1e-84
Identities = 183/633 (28%), Positives = 336/633 (53%), Gaps = 40/633 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 25 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 84
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 85 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 144
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 204
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 205 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 259
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 260 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 317
Query: 1501 KYYNAMKKMGSKKPL-KAIPRPRWR----PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ ++ S P +A RP + + + + T D+ I I +N++TM++
Sbjct: 318 RLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 377
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ +
Sbjct: 378 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 437
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 438 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 497
Query: 1673 FLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FI+A G+ F ++ GL F F + + LF++ST W+G++
Sbjct: 498 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 557
Query: 1728 IINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
+ EC D +C S + Y +++++++ +++N+ +AV++++ ++ +
Sbjct: 558 TL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 609
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
+ +E D + D E+ P ++ + D+
Sbjct: 610 EARE---DAELDAEIELEMAQGPGSARRVDADR 639
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 14 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 72
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 73 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 132
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 133 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 192
Query: 281 YMG 283
+ G
Sbjct: 193 FKG 195
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 344 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 403
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 404 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 459
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 460 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 512
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 465 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 522
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 523 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 559
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 359 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 396
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 198
>AF223563-1|AAF60163.1| 1536|Homo sapiens low-voltage-activated
calcium channel alpha13.2 subunit delta25B splice variant
protein.
Length = 1536
Score = 315 bits (773), Expect = 1e-84
Identities = 183/633 (28%), Positives = 336/633 (53%), Gaps = 40/633 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 467 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 526
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 527 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 586
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 587 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 646
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 647 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 701
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 702 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 759
Query: 1501 KYYNAMKKMGSKKPL-KAIPRPRWR----PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ ++ S P +A RP + + + + T D+ I I +N++TM++
Sbjct: 760 RLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 819
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ +
Sbjct: 820 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 879
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 880 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 939
Query: 1673 FLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FI+A G+ F ++ GL F F + + LF++ST W+G++
Sbjct: 940 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 999
Query: 1728 IINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
+ EC D +C S + Y +++++++ +++N+ +AV++++ ++ +
Sbjct: 1000 TL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1051
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
+ +E D + D E+ P ++ + D+
Sbjct: 1052 EARE---DAELDAEIELEMAQGPGSARRVDADR 1081
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 456 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 514
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 515 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 574
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 575 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 634
Query: 281 YMG 283
+ G
Sbjct: 635 FKG 637
Score = 76.6 bits (180), Expect = 8e-13
Identities = 62/240 (25%), Positives = 113/240 (47%), Gaps = 32/240 (13%)
Query: 1562 ETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDII 1620
E + L+ N++F +F+ E LLK+ A Y P+N+FD ++V+ S+ +V
Sbjct: 2 EELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--- 58
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
+ L V+R ++ RVL+LV+ +R L L ++ + C LL L +FIF+
Sbjct: 59 -----ADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFS 113
Query: 1681 IFGMSFF---MHVKDKGG--LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECD 1735
I GM F +K G + D NF + + +++ +FQ+ T W+ VL
Sbjct: 114 ILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-------- 165
Query: 1736 LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
G +++ Y ++ + ++ N+ +A+++E + QA D TD+D
Sbjct: 166 ---------GMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSDTDED 215
Score = 69.3 bits (162), Expect = 1e-10
Identities = 33/120 (27%), Positives = 71/120 (59%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++A G P Y+R+ +N D +++ ++ + +G
Sbjct: 5 TNALEISNIVFTSMFALEMLLKLLACG----PLGYIRNPYNIFDGIIVVISVWEIVGQAD 60
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR+LR LK V +P L+ + +++++ N+ L M + +F+++G+ ++
Sbjct: 61 GGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 120
Score = 67.3 bits (157), Expect = 5e-10
Identities = 59/236 (25%), Positives = 106/236 (44%), Gaps = 35/236 (14%)
Query: 1248 LQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAG 1307
L + L + +FT +F +EML+K LA G Y N + D IIV++S+ V G
Sbjct: 4 LTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--ADG 61
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
G+ +T R LR L+ +R + ++ VV LV+ + ++ + ++F IF+I+G+
Sbjct: 62 GLSVLRTFRLLRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMH 118
Query: 1368 LFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKG 1427
LF K+ D T +PD+ NFD + A + +FQ+ T +
Sbjct: 119 LFGCKFSLKTDTGDT------VPDRK--------------NFDSLLWAIVTVFQILTQED 158
Query: 1428 WIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
W ++ + + S T+ + LY NL + ++++ F +
Sbjct: 159 WNVVLYNGMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 204
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 786 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 845
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 846 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 901
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 902 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 954
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 66 LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS 125
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 126 LKTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 157
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 907 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 964
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 965 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 1001
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 801 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 838
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 587 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 640
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 139 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 198
Query: 405 MSY 407
+
Sbjct: 199 EGF 201
Score = 34.3 bits (75), Expect = 4.5
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 633 LLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEA 692
L G GK T + GR+A P A PL R +S L RPLR + T+C D
Sbjct: 350 LSGEGKGSTDDEAEDGRAAPG-------PRATPLRRAES-LDPRPLRPAALPPTKCRDRD 401
Query: 693 GKVLKPSSD 701
G+V+ SD
Sbjct: 402 GQVVALPSD 410
>AF073931-1|AAD17668.1| 2353|Homo sapiens low-voltage activated
calcium channel alpha 1H protein.
Length = 2353
Score = 315 bits (773), Expect = 1e-84
Identities = 183/633 (28%), Positives = 336/633 (53%), Gaps = 40/633 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 1464 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 1519 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 1576
Query: 1501 KYYNAMKKMGSKKPL-KAIPRPRWR----PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ ++ S P +A RP + + + + T D+ I I +N++TM++
Sbjct: 1577 RLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ +
Sbjct: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
Query: 1673 FLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FI+A G+ F ++ GL F F + + LF++ST W+G++
Sbjct: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
Query: 1728 IINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
+ EC D +C S + Y +++++++ +++N+ +AV++++ ++ +
Sbjct: 1817 TL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
+ +E D + D E+ P ++ + D+
Sbjct: 1869 EARE---DAELDAEIELEMAQGPGSARRVDADR 1898
Score = 95.5 bits (227), Expect = 2e-18
Identities = 73/270 (27%), Positives = 132/270 (48%), Gaps = 32/270 (11%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IV K F IM+ I +N L+M +++++Q E + L+ N++F +F+ E LLK+ A
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
Query: 1592 -YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y P+N+FD ++V+ S+ +V + L V+R ++ RVL+LV+
Sbjct: 849 PLGYIRNPYNIFDGIIVVISVWEIVGQ--------ADGGLSVLRTFRLLRVLKLVRFLPA 900
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF---MHVKDKGG--LDDVYNFKTF 1705
+R L L ++ + C LL L +FIF+I GM F +K G + D NF +
Sbjct: 901 LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++ +FQ+ T W+ VL G +++ Y ++ +
Sbjct: 961 LWAIVTVFQILTQEDWNVVLYN-----------------GMASTSSWAALYFVALMTFGN 1003
Query: 1766 LIVINMYIAVILENYSQATEDVQEGLTDDD 1795
++ N+ +A+++E + QA D TD+D
Sbjct: 1004 YVLFNLLVAILVEGF-QAEGDANRSDTDED 1032
Score = 95.1 bits (226), Expect = 2e-18
Identities = 61/166 (36%), Positives = 95/166 (57%), Gaps = 13/166 (7%)
Query: 1213 KLIENTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEML 1268
+L+ N +FE + +I+L+ + L + EDV +IL D F +EM+
Sbjct: 95 RLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFFAVEMV 152
Query: 1269 IKWLALGF--QK-YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
IK +ALG QK Y + W LDF IV+ ++ + +L G + +RT+R LRPLR
Sbjct: 153 IKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEY--SLDGHN--VSLSAIRTVRVLRPLR 208
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
A++R+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
Score = 87.4 bits (207), Expect = 5e-16
Identities = 72/287 (25%), Positives = 132/287 (45%), Gaps = 39/287 (13%)
Query: 1199 PFWQG--WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
P W G W T K +++++ YF ++ IL+++L++ +E P L + L +
Sbjct: 772 PGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEE--LTNALEISN 829
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+FT +F +EML+K LA G Y N + D IIV++S+ V GG+ +T R
Sbjct: 830 IVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--ADGGLSVLRTFR 887
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR L+ +R + ++ VV LV+ + ++ + ++F IF+I+G+ LF K+
Sbjct: 888 LLRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK 944
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T +PD+ NFD + A + +FQ+ T + W ++ + +
Sbjct: 945 TDTGDT------VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGM 984
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
S T+ + LY NL + ++++ F +
Sbjct: 985 AS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 1331
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 1332 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 1391
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 1392 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1451
Query: 281 YMG 283
+ G
Sbjct: 1452 FKG 1454
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/172 (26%), Positives = 88/172 (51%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTF 179
R + ++ +P F + I++NC+ M P +E+ + +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G Q YL D WN LDF ++ + +D N L+A+RT RVLR L+
Sbjct: 150 EMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
Score = 70.5 bits (165), Expect = 6e-11
Identities = 41/147 (27%), Positives = 82/147 (55%), Gaps = 12/147 (8%)
Query: 143 FSLFIITTILVNCILMIMP-------TTPTVESTEVIFTGIYTFESAVKVMARGFILQPF 195
FS I+ ILVN + M + T +E + ++FT ++ E +K++A G P
Sbjct: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850
Query: 196 TYLRDAWNWLDFVVIALA-YVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
Y+R+ +N D +++ ++ + +G G L+ LRTFR+LR LK V +P L+ + +++
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIY 281
++ N+ L M + +F+++G+ ++
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 15/172 (8%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL----DHYQQSETFSAVLDYLNMIFIVIF 1579
RP++ +V + F+ + ML I LN +T+ + + + +L+ + F
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
Query: 1580 SSECLLKIFALRYH----YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
+ E ++K+ AL Y + WN DF +V+ ++ L + + VS + +R VRV
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVSLSAIRTVRV 203
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 204 L---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 883 LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS 942
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 943 LKTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 974
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 10/94 (10%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + N +NFD++G A++ +FQV T +GW+ IM +D+ + Y
Sbjct: 345 NVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFY 394
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++Y +NL + VI F+E K++
Sbjct: 395 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 428
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/78 (28%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIF 389
VC G NP+ G +FD G+A+++ F+++T + W ++ ++F+++I
Sbjct: 346 VCRSG-DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 404
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 405 VGSFFMINLCLVVIATQF 422
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 1724 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 1781
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 1782 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 1818
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 1655
Score = 42.3 bits (95), Expect = 0.017
Identities = 20/77 (25%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
+V + +LD HN+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 179 VVAGMMEYSLDGHNVSLS---AIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 235
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 236 LCFFVFFIFGIVGVQLW 252
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1457
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 405 MSY 407
+
Sbjct: 1016 EGF 1018
Score = 34.3 bits (75), Expect = 4.5
Identities = 15/52 (28%), Positives = 28/52 (53%)
Query: 780 LWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
LW+ F + +V + I + I+VNTL M +++H +++ AL+ N
Sbjct: 778 LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISN 829
Score = 34.3 bits (75), Expect = 4.5
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 633 LLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEA 692
L G GK T + GR+A P A PL R +S L RPLR + T+C D
Sbjct: 1167 LSGEGKGSTDDEAEDGRAAPG-------PRATPLRRAES-LDPRPLRPAALPPTKCRDRD 1218
Query: 693 GKVLKPSSD 701
G+V+ SD
Sbjct: 1219 GQVVALPSD 1227
>AF051946-1|AAC67239.3| 2353|Homo sapiens T-type calcium channel alpha
1H subunit protein.
Length = 2353
Score = 315 bits (773), Expect = 1e-84
Identities = 183/633 (28%), Positives = 336/633 (53%), Gaps = 40/633 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 1464 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 1519 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 1576
Query: 1501 KYYNAMKKMGSKKPL-KAIPRPRWR----PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ ++ S P +A RP + + + + T D+ I I +N++TM++
Sbjct: 1577 RLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ +
Sbjct: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
Query: 1673 FLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FI+A G+ F ++ GL F F + + LF++ST W+G++
Sbjct: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
Query: 1728 IINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
+ EC D +C S + Y +++++++ +++N+ +AV++++ ++ +
Sbjct: 1817 TL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
+ +E D + D E+ P ++ + D+
Sbjct: 1869 EARE---DAELDAEIELEMAQGPGSARRVDADR 1898
Score = 95.5 bits (227), Expect = 2e-18
Identities = 73/270 (27%), Positives = 132/270 (48%), Gaps = 32/270 (11%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IV K F IM+ I +N L+M +++++Q E + L+ N++F +F+ E LLK+ A
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
Query: 1592 -YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y P+N+FD ++V+ S+ +V + L V+R ++ RVL+LV+
Sbjct: 849 PLGYIRNPYNIFDGIIVVISVWEIVGQ--------ADGGLSVLRTFRLLRVLKLVRFLPA 900
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF---MHVKDKGG--LDDVYNFKTF 1705
+R L L ++ + C LL L +FIF+I GM F +K G + D NF +
Sbjct: 901 LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++ +FQ+ T W+ VL G +++ Y ++ +
Sbjct: 961 LWAIVTVFQILTQEDWNVVLYN-----------------GMASTSSWAALYFVALMTFGN 1003
Query: 1766 LIVINMYIAVILENYSQATEDVQEGLTDDD 1795
++ N+ +A+++E + QA D TD+D
Sbjct: 1004 YVLFNLLVAILVEGF-QAEGDANRSDTDED 1032
Score = 95.1 bits (226), Expect = 2e-18
Identities = 61/166 (36%), Positives = 95/166 (57%), Gaps = 13/166 (7%)
Query: 1213 KLIENTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEML 1268
+L+ N +FE + +I+L+ + L + EDV +IL D F +EM+
Sbjct: 95 RLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFFAVEMV 152
Query: 1269 IKWLALGF--QK-YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
IK +ALG QK Y + W LDF IV+ ++ + +L G + +RT+R LRPLR
Sbjct: 153 IKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEY--SLDGHN--VSLSAIRTVRVLRPLR 208
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
A++R+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
Score = 87.4 bits (207), Expect = 5e-16
Identities = 72/287 (25%), Positives = 132/287 (45%), Gaps = 39/287 (13%)
Query: 1199 PFWQG--WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
P W G W T K +++++ YF ++ IL+++L++ +E P L + L +
Sbjct: 772 PGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEE--LTNALEISN 829
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+FT +F +EML+K LA G Y N + D IIV++S+ V GG+ +T R
Sbjct: 830 IVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--ADGGLSVLRTFR 887
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR L+ +R + ++ VV LV+ + ++ + ++F IF+I+G+ LF K+
Sbjct: 888 LLRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK 944
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T +PD+ NFD + A + +FQ+ T + W ++ + +
Sbjct: 945 TDTGDT------VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGM 984
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
S T+ + LY NL + ++++ F +
Sbjct: 985 AS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 1331
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 1332 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 1391
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 1392 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1451
Query: 281 YMG 283
+ G
Sbjct: 1452 FKG 1454
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/172 (26%), Positives = 88/172 (51%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPTTPT---------VESTEVIFTGIYTF 179
R + ++ +P F + I++NC+ M P +E+ + +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G Q YL D WN LDF ++ + +D N L+A+RT RVLR L+
Sbjct: 150 EMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
Score = 70.5 bits (165), Expect = 6e-11
Identities = 41/147 (27%), Positives = 82/147 (55%), Gaps = 12/147 (8%)
Query: 143 FSLFIITTILVNCILMIMP-------TTPTVESTEVIFTGIYTFESAVKVMARGFILQPF 195
FS I+ ILVN + M + T +E + ++FT ++ E +K++A G P
Sbjct: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850
Query: 196 TYLRDAWNWLDFVVIALA-YVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
Y+R+ +N D +++ ++ + +G G L+ LRTFR+LR LK V +P L+ + +++
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIY 281
++ N+ L M + +F+++G+ ++
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 15/172 (8%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL----DHYQQSETFSAVLDYLNMIFIVIF 1579
RP++ +V + F+ + ML I LN +T+ + + + +L+ + F
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
Query: 1580 SSECLLKIFALRYH----YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRV 1635
+ E ++K+ AL Y + WN DF +V+ ++ L + + VS + +R VRV
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVSLSAIRTVRV 203
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 204 L---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 883 LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS 942
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 943 LKTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 974
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 10/94 (10%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + N +NFD++G A++ +FQV T +GW+ IM +D+ + Y
Sbjct: 345 NVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFY 394
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++Y +NL + VI F+E K++
Sbjct: 395 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 428
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/78 (28%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIF 389
VC G NP+ G +FD G+A+++ F+++T + W ++ ++F+++I
Sbjct: 346 VCRSG-DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 404
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 405 VGSFFMINLCLVVIATQF 422
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 1724 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 1781
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 1782 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 1818
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 1655
Score = 42.3 bits (95), Expect = 0.017
Identities = 20/77 (25%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
+V + +LD HN+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 179 VVAGMMEYSLDGHNVSLS---AIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 235
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 236 LCFFVFFIFGIVGVQLW 252
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1457
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 405 MSY 407
+
Sbjct: 1016 EGF 1018
Score = 34.3 bits (75), Expect = 4.5
Identities = 15/52 (28%), Positives = 28/52 (53%)
Query: 780 LWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
LW+ F + +V + I + I+VNTL M +++H +++ AL+ N
Sbjct: 778 LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISN 829
Score = 34.3 bits (75), Expect = 4.5
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 633 LLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEA 692
L G GK T + GR+A P A PL R +S L RPLR + T+C D
Sbjct: 1167 LSGEGKGSTDDEAEDGRAAPG-------PRATPLRRAES-LDPRPLRPAALPPTKCRDRD 1218
Query: 693 GKVLKPSSD 701
G+V+ SD
Sbjct: 1219 GQVVALPSD 1227
>AE006466-3|AAK61268.1| 2373|Homo sapiens voltage dependent t-type
calcium channel alpha-1H subunit protein.
Length = 2373
Score = 315 bits (773), Expect = 1e-84
Identities = 183/633 (28%), Positives = 336/633 (53%), Gaps = 40/633 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 1304 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1363
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 1364 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1423
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 1424 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1483
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 1484 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1538
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 1539 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 1596
Query: 1501 KYYNAMKKMGSKKPL-KAIPRPRWR----PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ ++ S P +A RP + + + + T D+ I I +N++TM++
Sbjct: 1597 RLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1656
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+ S++ +
Sbjct: 1657 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1716
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLL 1672
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1717 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1776
Query: 1673 FLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDG 1727
L+ FI+A G+ F ++ GL F F + + LF++ST W+G++
Sbjct: 1777 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1836
Query: 1728 IINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
+ EC D +C S + Y +++++++ +++N+ +AV++++ ++ +
Sbjct: 1837 TL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1888
Query: 1786 DVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
+ +E D + D E+ P ++ + D+
Sbjct: 1889 EARE---DAELDAEIELEMAQGPGSARRVDADR 1918
Score = 95.5 bits (227), Expect = 2e-18
Identities = 73/270 (27%), Positives = 132/270 (48%), Gaps = 32/270 (11%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
IV K F IM+ I +N L+M +++++Q E + L+ N++F +F+ E LLK+ A
Sbjct: 809 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 868
Query: 1592 -YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1650
Y P+N+FD ++V+ S+ +V + L V+R ++ RVL+LV+
Sbjct: 869 PLGYIRNPYNIFDGIIVVISVWEIVGQ--------ADGGLSVLRTFRLLRVLKLVRFLPA 920
Query: 1651 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF---MHVKDKGG--LDDVYNFKTF 1705
+R L L ++ + C LL L +FIF+I GM F +K G + D NF +
Sbjct: 921 LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 980
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISF 1765
+ +++ +FQ+ T W+ VL G +++ Y ++ +
Sbjct: 981 LWAIVTVFQILTQEDWNVVLYN-----------------GMASTSSWAALYFVALMTFGN 1023
Query: 1766 LIVINMYIAVILENYSQATEDVQEGLTDDD 1795
++ N+ +A+++E + QA D TD+D
Sbjct: 1024 YVLFNLLVAILVEGF-QAEGDANRSDTDED 1052
Score = 93.5 bits (222), Expect = 7e-18
Identities = 60/162 (37%), Positives = 93/162 (57%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
+T+FE + +I+L+ + L + EDV +IL D F +EM+IK +
Sbjct: 119 DTWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFFAVEMVIKMV 176
Query: 1273 ALGF--QK-YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG QK Y + W LDF IV+ ++ + +L G + +RT+R LRPLRA++R
Sbjct: 177 ALGLFGQKCYLGDTWNRLDFFIVVAGMMEY--SLDGHN--VSLSAIRTVRVLRPLRAINR 232
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 233 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 274
Score = 87.4 bits (207), Expect = 5e-16
Identities = 72/287 (25%), Positives = 132/287 (45%), Gaps = 39/287 (13%)
Query: 1199 PFWQG--WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
P W G W T K +++++ YF ++ IL+++L++ +E P L + L +
Sbjct: 792 PGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEE--LTNALEISN 849
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+FT +F +EML+K LA G Y N + D IIV++S+ V GG+ +T R
Sbjct: 850 IVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ--ADGGLSVLRTFR 907
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR L+ +R + ++ VV LV+ + ++ + ++F IF+I+G+ LF K+
Sbjct: 908 LLRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK 964
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T +PD+ NFD + A + +FQ+ T + W ++ + +
Sbjct: 965 TDTGDT------VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGM 1004
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
S T+ + LY NL + ++++ F +
Sbjct: 1005 AS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1041
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 1293 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 1351
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 1352 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 1411
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 1412 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1471
Query: 281 YMG 283
+ G
Sbjct: 1472 FKG 1474
Score = 78.6 bits (185), Expect = 2e-13
Identities = 38/126 (30%), Positives = 72/126 (57%), Gaps = 3/126 (2%)
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN-- 223
+E+ + + E +K++A G Q YL D WN LDF ++ + +D N
Sbjct: 156 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 214
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+A+RT RVLR L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G
Sbjct: 215 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 274
Query: 284 VLTQKC 289
+L +C
Sbjct: 275 LLRNRC 280
Score = 70.5 bits (165), Expect = 6e-11
Identities = 41/147 (27%), Positives = 82/147 (55%), Gaps = 12/147 (8%)
Query: 143 FSLFIITTILVNCILMIMP-------TTPTVESTEVIFTGIYTFESAVKVMARGFILQPF 195
FS I+ ILVN + M + T +E + ++FT ++ E +K++A G P
Sbjct: 815 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 870
Query: 196 TYLRDAWNWLDFVVIALA-YVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 254
Y+R+ +N D +++ ++ + +G G L+ LRTFR+LR LK V +P L+ + +++
Sbjct: 871 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 930
Query: 255 SVKNLRDVIILTMFSLSVFALMGLQIY 281
++ N+ L M + +F+++G+ ++
Sbjct: 931 TMDNVATFCTLLMLFIFIFSILGMHLF 957
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 1623 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1682
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 1683 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1738
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 1739 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1791
Score = 58.4 bits (135), Expect = 2e-07
Identities = 46/161 (28%), Positives = 76/161 (47%), Gaps = 15/161 (9%)
Query: 1535 DKKFDMIIMLFIGLNMLTMTL----DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
D F+ + ML I LN +T+ + + + +L+ + F+ E ++K+ AL
Sbjct: 119 DTWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVAL 178
Query: 1591 RYH----YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVK 1646
Y + WN DF +V+ ++ L + + VS + +R VRV R LR +
Sbjct: 179 GLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVSLSAIRTVRVL---RPLRAIN 231
Query: 1647 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 232 RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 272
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 903 LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS 962
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 963 LKTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 994
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 10/94 (10%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + N +NFD++G A++ +FQV T +GW+ IM +D+ + Y
Sbjct: 365 NVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFY 414
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++Y +NL + VI F+E K++
Sbjct: 415 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 448
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/78 (28%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-----------LFFVVIIF 389
VC G NP+ G +FD G+A+++ F+++T + W ++ ++F+++I
Sbjct: 366 VCRSG-DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 424
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 425 VGSFFMINLCLVVIATQF 442
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 1744 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 1801
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 1802 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 1838
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 1638 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 1675
Score = 42.3 bits (95), Expect = 0.017
Identities = 20/77 (25%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
+V + +LD HN+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 199 VVAGMMEYSLDGHNVSLS---AIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 255
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 256 LCFFVFFIFGIVGVQLW 272
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1424 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1477
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 976 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1035
Query: 405 MSY 407
+
Sbjct: 1036 EGF 1038
Score = 34.3 bits (75), Expect = 4.5
Identities = 15/52 (28%), Positives = 28/52 (53%)
Query: 780 LWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
LW+ F + +V + I + I+VNTL M +++H +++ AL+ N
Sbjct: 798 LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISN 849
Score = 34.3 bits (75), Expect = 4.5
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 633 LLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEA 692
L G GK T + GR+A P A PL R +S L RPLR + T+C D
Sbjct: 1187 LSGEGKGSTDDEAEDGRAAPG-------PRATPLRRAES-LDPRPLRPAALPPTKCRDRD 1238
Query: 693 GKVLKPSSD 701
G+V+ SD
Sbjct: 1239 GQVVALPSD 1247
>AF004884-1|AAB61613.1| 2510|Homo sapiens neuronal calcium channel
alpha 1A subunit isoform A-1 protein.
Length = 2510
Score = 314 bits (772), Expect = 2e-84
Identities = 207/706 (29%), Positives = 361/706 (51%), Gaps = 43/706 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1236 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1294
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1295 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1354
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1355 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1414
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1415 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1474
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1475 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1531
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1532 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1589
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 1590 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 1649
Query: 1616 LSDI-IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFL 1674
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ +
Sbjct: 1650 VTEFGNPNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1706
Query: 1675 VMFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGV 1724
+ FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W +
Sbjct: 1707 LFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNI 1766
Query: 1725 LDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQAT 1784
+ ++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1767 MLSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT 1823
Query: 1785 EDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK- 1839
D L D Y +W +DP + Y + L + PPL + K P + YK
Sbjct: 1824 RD-SSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKR 1882
Query: 1840 IISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
++ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1883 LLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1928
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1225 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1284
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1285 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1344
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1345 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1404
Score = 98.3 bits (234), Expect = 2e-19
Identities = 77/314 (24%), Positives = 138/314 (43%), Gaps = 35/314 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 476 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 534 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 593
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 640
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ+ T + W ++M D I S Q
Sbjct: 641 ------------NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGG 683
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF---NEQKKKAGGSLEMFMTEDQKKYY 1503
+ + +Y LN+F+ + +DN E K E +QK
Sbjct: 684 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKVEADEQEEEEAANQKLAL 743
Query: 1504 NAMKKMGSKKPLKA 1517
K++ PL A
Sbjct: 744 QKAKEVAEVSPLSA 757
Score = 93.5 bits (222), Expect = 7e-18
Identities = 68/264 (25%), Positives = 129/264 (48%), Gaps = 18/264 (6%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 591
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 651
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF +++ +FQ+ T W+ V+ DGI + G G I +++ L
Sbjct: 652 DTFPAAIMTVFQILTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 699
Query: 1762 VISFLIVINMYIAVILENYSQATE 1785
++ + +N+++A+ ++N + A E
Sbjct: 700 FGNYTL-LNVFLAIAVDNLANAQE 722
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 67.3 bits (157), Expect = 5e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF++L GE W E M+D
Sbjct: 641 -----NFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 676
Score = 61.3 bits (142), Expect = 3e-08
Identities = 45/159 (28%), Positives = 81/159 (50%), Gaps = 20/159 (12%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 1566 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1625
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVT--MGIDLGN------LAALRTFRVLRALKTVAIV 242
+ Y RDAWN DFV + L +T + + GN L+ LR FR R +K +
Sbjct: 1626 L----NYFRDAWNIFDFVTV-LGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQG 1680
Query: 243 PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1681 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1719
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1672 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1731
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1732 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1771
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 523 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 579 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 283 G 283
G
Sbjct: 638 G 638
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1332 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1391
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1392 FIFAVVAVQLFKGKFFHCTD 1411
>AF004883-1|AAB61612.1| 2266|Homo sapiens neuronal calcium channel
alpha 1A subunit isoform 1A-2 protein.
Length = 2266
Score = 314 bits (772), Expect = 2e-84
Identities = 207/706 (29%), Positives = 361/706 (51%), Gaps = 43/706 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1236 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 1294
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 1295 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1354
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 1355 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 1414
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 1415 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 1474
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 1475 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 1531
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 1532 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 1589
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 1590 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 1649
Query: 1616 LSDI-IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFL 1674
+++ F++ + LR+ R A R+++L++ IR LL+ S AL +CLL+ +
Sbjct: 1650 VTEFGNPNNFINLSFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1706
Query: 1675 VMFIFAIFGMSFF----MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGV 1724
+ FI+AI GM F + V+D+ +D + NF+TF Q+++LLF+ +T W +
Sbjct: 1707 LFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNI 1766
Query: 1725 LDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQAT 1784
+ ++ + CD N CG+ Y +S++ + +++N+++AVI++N+ T
Sbjct: 1767 MLSCLSGKPCD--KNSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT 1823
Query: 1785 EDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK- 1839
D L D Y +W +DP + Y + L + PPL + K P + YK
Sbjct: 1824 RD-SSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKR 1882
Query: 1840 IISMDIPICRGDMMFCVDILDALTK---DFFARKGNPIEETGDLEV 1882
++ MD+P+ + + L AL + D KG ++ D E+
Sbjct: 1883 LLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1928
Score = 138 bits (335), Expect = 1e-31
Identities = 92/312 (29%), Positives = 159/312 (50%), Gaps = 47/312 (15%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPT 165
+ +L++ N +R+ A I P F I+ TI+ NCI++ + P +
Sbjct: 73 TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER 132
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNL 224
++ TE F GI+ FE+ +K++A GF +YLR+ WN +DFVV+ + T+G + +L
Sbjct: 133 LDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DL 191
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR LK V+ +P L+ ++ ++++++ L + +L F++ +FA++GL+ YMG
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 285 LTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQ 344
C E+G TD+ +G CG A C G C Q
Sbjct: 252 FHTTCF----EEG-----TDDI-------------QGESPAPCGTEEPARTCPNGTKC-Q 288
Query: 345 GFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ------------LFFVVIIFLGS 392
+ PN G T FD +A L+ F+ +T + W +L L+F+ +I +GS
Sbjct: 289 PYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGS 348
Query: 393 FYLVNLILAIVA 404
F+++NL+L +++
Sbjct: 349 FFMLNLVLGVLS 360
Score = 111 bits (266), Expect = 3e-23
Identities = 59/180 (32%), Positives = 103/180 (57%), Gaps = 15/180 (8%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTE 170
++++IL NP+RR+ YIL F + I+ I ++ I + + P P + +
Sbjct: 1225 SSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFD 1284
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGN 223
+FTG++TFE +K++ G +L Y RD WN LDF+V++ A V G D+
Sbjct: 1285 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT 1344
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
+ +LR RVLR LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 1345 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1404
Score = 98.3 bits (234), Expect = 2e-19
Identities = 77/314 (24%), Positives = 138/314 (43%), Gaps = 35/314 (11%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R ++++ F V++++ L++L +A+ VH L D LYY + IF +F E
Sbjct: 476 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAI--VHYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
M IK LG + YF +++ D +++ S+ + A+ G +R LR LR +
Sbjct: 534 MFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKV 593
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+R +V +L+ ++ SI ++L + +F ++FA++G+QLF G++
Sbjct: 594 TKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 640
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
N+ P NFD A + +FQ+ T + W ++M D I S Q
Sbjct: 641 ------------NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKS-----QGG 683
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF---NEQKKKAGGSLEMFMTEDQKKYY 1503
+ + +Y LN+F+ + +DN E K E +QK
Sbjct: 684 VQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKVEADEQEEEEAANQKLAL 743
Query: 1504 NAMKKMGSKKPLKA 1517
K++ PL A
Sbjct: 744 QKAKEVAEVSPLSA 757
Score = 93.5 bits (222), Expect = 7e-18
Identities = 68/264 (25%), Positives = 129/264 (48%), Gaps = 18/264 (6%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + + +V + F ++ + LN L + + HY Q E S L Y IF+ +F SE
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVL 1642
+K++ L YF +N FD V++ SI ++ + I ++LR +R+ R+
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLL---RIF 591
Query: 1643 RLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNF 1702
++ K +R L+ +L S+ ++ ++ LLFL + +FA+ GM F + NF
Sbjct: 592 KVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNF 651
Query: 1703 KTFVQSMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYL 1761
TF +++ +FQ+ T W+ V+ DGI + G G I +++ L
Sbjct: 652 DTFPAAIMTVFQILTGEDWNEVMYDGI------------KSQGGVQGGMVFSIYFIVLTL 699
Query: 1762 VISFLIVINMYIAVILENYSQATE 1785
++ + +N+++A+ ++N + A E
Sbjct: 700 FGNYTL-LNVFLAIAVDNLANAQE 722
Score = 92.3 bits (219), Expect = 2e-17
Identities = 80/293 (27%), Positives = 141/293 (48%), Gaps = 35/293 (11%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPH--RPILQDILYYMDRIFTVIFFIEMLIK 1270
K+ E FE ++ I+ + + LALE HLP + + + L + F IF E IK
Sbjct: 93 KITEWPPFEYMILATIIANCIVLALEQ-HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 1271 WLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
+ALGF Y N W +DF++V+ ++ V G +T+R +R LRPL+
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV------GTEFDLRTLRAVRVLRPLKL 205
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF-KCVDMNHTTLS 1385
+S + ++VV+ ++++A+ + + L+ LIFAI+G++ + GK+ C + +
Sbjct: 206 VSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQ 265
Query: 1386 HEI-IP---DKNACTLENYT-----WE---NSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
E P ++ A T N T WE N FD++ A L +FQ T +GW ++
Sbjct: 266 GESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY 325
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
++ D+ N + +LY LNL +GV+ F +++++
Sbjct: 326 NSNDA---------SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 369
Score = 68.9 bits (161), Expect = 2e-10
Identities = 52/159 (32%), Positives = 80/159 (50%), Gaps = 17/159 (10%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSET---FSAVLDYLNMIFIVIFSSECLLKIFAL--RY 1592
F+ +I+ I N + + L+ + + S LD FI IF E +KI AL +
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1593 H---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
H Y WN+ DFVVV+ IL+ V ++ LR +R +V R L+LV G
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFD---------LRTLRAVRVLRPLKLVSGIP 210
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +L ++ ++ L I LLLF + IFAI G+ F+M
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYM 249
Score = 67.3 bits (157), Expect = 5e-10
Identities = 40/102 (39%), Positives = 64/102 (62%), Gaps = 9/102 (8%)
Query: 827 LKSGNYLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY 885
L++ LR+FK+ K W +L NL++S++ +M ++ +L F+L + I +FA++GMQLFG +
Sbjct: 582 LRALRLLRIFKVTKYWASLRNLVVSLLN-SMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
Query: 886 VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F +G P NF F + M VF++L GE W E M+D
Sbjct: 641 -----NFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 676
Score = 61.3 bits (142), Expect = 3e-08
Identities = 45/159 (28%), Positives = 81/159 (50%), Gaps = 20/159 (12%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 1566 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 1625
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVT--MGIDLGN------LAALRTFRVLRALKTVAIV 242
+ Y RDAWN DFV + L +T + + GN L+ LR FR R +K +
Sbjct: 1626 L----NYFRDAWNIFDFVTV-LGSITDILVTEFGNPNNFINLSFLRLFRAARLIKLLRQG 1680
Query: 243 PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
++ ++ ++S K L V +L ++A++G+Q++
Sbjct: 1681 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1719
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 1672 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1731
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 1732 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1771
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E IF G++ E +K+ G +P Y ++N D VI A + G G
Sbjct: 523 EFIFLGLFMSEMFIKMYGLG--TRP--YFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
++ LR R+LR K L+ +V +++ S+K++ ++ L + VFAL+G+Q++
Sbjct: 579 -ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 283 G 283
G
Sbjct: 638 G 638
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 1332 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 1391
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 1392 FIFAVVAVQLFKGKFFHCTD 1411
>DQ494465-1|ABF69916.1| 2332|Homo sapiens T calcium channel alpha 1G
subunit variant 189 protein.
Length = 2332
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>DQ494464-1|ABF69915.1| 2284|Homo sapiens T calcium channel alpha 1G
subunit variant 185 protein.
Length = 2284
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>DQ494463-1|ABF69914.1| 2205|Homo sapiens T calcium channel alpha 1G
subunit variant 184 protein.
Length = 2205
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>DQ494453-1|ABF69904.1| 2261|Homo sapiens T calcium channel alpha 1G
subunit variant 57 protein.
Length = 2261
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1778 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1829 KHLEESNKEAKE 1840
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1744
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1745 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1786
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1787 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1752
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1753 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1789
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>BC110995-1|AAI10996.1| 2261|Homo sapiens calcium channel,
voltage-dependent, T type, alpha 1G subunit protein.
Length = 2261
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1778 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1829 KHLEESNKEAKE 1840
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1744
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1745 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1786
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1787 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1752
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1753 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1789
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>AF227750-1|AAF37695.1| 2332|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform bcef protein.
Length = 2332
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>AF227749-1|AAF37694.1| 2284|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform bce protein.
Length = 2284
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>AF227748-1|AAF37693.1| 2306|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform bcd protein.
Length = 2306
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1778 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1829 KHLEESNKEAKE 1840
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1744
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1745 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1786
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1787 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1752
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1753 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1789
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>AF227747-1|AAF37692.1| 2261|Homo sapiens voltage-dependent calcium
channel alpha 1G subunit isoform bc protein.
Length = 2261
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1718 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1777
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1778 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1829 KHLEESNKEAKE 1840
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1744
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1745 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1786
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1787 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1695 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1752
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1753 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1789
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>AF134986-1|AAF19347.1| 2377|Homo sapiens T calcium channel alpha1G
subunit protein.
Length = 2377
Score = 314 bits (771), Expect = 2e-84
Identities = 186/612 (30%), Positives = 331/612 (54%), Gaps = 44/612 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
P + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1741 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1800
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1801 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1852 KHLEESNKEAKE 1863
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1767
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1768 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1810 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1718 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1775
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1776 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>M83566-1|AAA35629.1| 2181|Homo sapiens calcium channel alpha-1
subunit protein.
Length = 2181
Score = 314 bits (770), Expect = 3e-84
Identities = 214/685 (31%), Positives = 358/685 (52%), Gaps = 50/685 (7%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ KLI + F ++ I+LSS ALA ED H IL Y D FT IF +E
Sbjct: 895 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHS-FRNTILGYFDYAFTAIFTVE 953
Query: 1267 MLIKWLALG--FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G K + N + LD ++V VSL++F + I K +R LR LR
Sbjct: 954 ILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQ---SSAISVVKILRVLRVLR 1010
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD---M 1379
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK+++C D
Sbjct: 1011 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 1070
Query: 1380 NHTTLSHEII----PDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
N I D ++ + W+NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1071 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1130
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + + ++ +N+F+G +I F EQ +K + E+
Sbjct: 1131 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDK 1190
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ + Q + +V F+ ++ + I LN L +
Sbjct: 1191 NQRQCVEY-ALK----ARPLRRYIPKNPY--QYKFWYVVNSSPFEYMMFVLIMLNTLCLA 1243
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILS 1613
+ HY+QS+ F+ +D LNM+F +F+ E +LK+ A + YF + WN FD ++V+ SI+
Sbjct: 1244 MQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIID 1303
Query: 1614 LVLS--DIIEKYFVS-PTL------------LRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1658
+ LS D E V PT + R+ +V R+++L+ +GIRTLL+
Sbjct: 1304 VALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1363
Query: 1659 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMS 1716
S AL + LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +
Sbjct: 1364 IKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCA 1423
Query: 1717 TSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAV 1775
T W ++ + + CD D G CGS I Y +S+ ++ ++IN+++AV
Sbjct: 1424 TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGS-NFAIVYFISFYMLCAFLIINLFVAV 1482
Query: 1776 ILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK- 1834
I++N+ T D L D + IW +DP+ I++ + L ++PPL K
Sbjct: 1483 IMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKL 1541
Query: 1835 -PNKY---KIISMDIPI-CRGDMMF 1854
P++ ++++M++P+ G +MF
Sbjct: 1542 CPHRVACKRLVAMNMPLNSDGTVMF 1566
Score = 124 bits (300), Expect = 2e-27
Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 63/325 (19%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL+ L NPIRR I I+ F +FI+ I NC+ + + T +E
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E F I+T E+ +K++A G +L P Y+R+ WN LDFV++ L +T + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 223 N----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
N + ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C F D ++ E D C S
Sbjct: 285 YAIIGLELFIGKMHKTC---FFAD---SDIVAEE----------------DPAPCAFSGN 322
Query: 333 AGQCEP-GYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY---------- 380
QC G C G+ PN G T+FD F +A L+ F+ +T + W + LY
Sbjct: 323 GRQCTANGTECRSGW-VGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEW 381
Query: 381 -QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 382 PWVYFVSLIILGSFFVLNLVLGVLS 406
Score = 101 bits (241), Expect = 3e-20
Identities = 67/252 (26%), Positives = 129/252 (51%), Gaps = 24/252 (9%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFV 1596
F ++++ + LN LT++ +HY Q + + + D N + + +F+ E L+K+++L YFV
Sbjct: 545 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFV 604
Query: 1597 EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF 1656
+N FD VV I +L +E +SP + V R ++ R+ ++ + + L+
Sbjct: 605 SLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVA 661
Query: 1657 ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILL 1712
+L S+ ++ ++ LLLFL + IF++ GM F K D+ F F Q+++ +
Sbjct: 662 SLLNSMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDETQTKRSTFDNFPQALLTV 718
Query: 1713 FQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINM 1771
FQ+ T W+ V+ DGI+ G P + G I Y + + I++N+
Sbjct: 719 FQILTGEDWNAVMYDGIM----------AYGGPSSSG--MIVCIYFIILFICGNYILLNV 766
Query: 1772 YIAVILENYSQA 1783
++A+ ++N + A
Sbjct: 767 FLAIAVDNLADA 778
Score = 90.2 bits (214), Expect = 6e-17
Identities = 80/311 (25%), Positives = 141/311 (45%), Gaps = 39/311 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E F+ ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTV 174
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALC-----------GAGGIQ 1310
F++++ L L Y N W LDF+IV+V L + + G G
Sbjct: 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 234
Query: 1311 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF
Sbjct: 235 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294
Query: 1371 GKYFK-CVDMNHTTLSHE------IIPDKNACTLENYT----W---ENSPMNFDHVGKAY 1416
GK K C + ++ E + CT W NFD+ A
Sbjct: 295 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 354
Query: 1417 LCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVI 1476
L +FQ T +GW ++ D+ +G + + ++Y LNL +GV+
Sbjct: 355 LTVFQCITMEGWTDVLYWVNDA--IGWE-------WPWVYFVSLIILGSFFVLNLVLGVL 405
Query: 1477 IDNFNEQKKKA 1487
F+++++KA
Sbjct: 406 SGEFSKEREKA 416
Score = 76.2 bits (179), Expect = 1e-12
Identities = 67/305 (21%), Positives = 134/305 (43%), Gaps = 37/305 (12%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIF 1259
W+ W R + +++ F VI ++ L++L ++ E + P L I +++
Sbjct: 525 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW--LTQIQDIANKVL 582
Query: 1260 TVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA---LCGAGGIQAFKTMR 1316
+F EML+K +LG Q YF + + D +V + + + GI F+ +R
Sbjct: 583 LALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVR 642
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR + R + + + V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 643 LLRIFKVTRHWTSLSNL---VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 696
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ + T + FD+ +A L +FQ+ T + W +M D I
Sbjct: 697 -NFDET--------------------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGI 735
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ + + + +Y LN+F+ + +DN + + E
Sbjct: 736 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791
Query: 1497 EDQKK 1501
+++KK
Sbjct: 792 KERKK 796
Score = 70.9 bits (166), Expect = 4e-11
Identities = 45/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPTVEST-----E 170
+A +IL NPIR ++ H +F+ I+ I+++ + + + +T +
Sbjct: 884 SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD 943
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTF 230
FT I+T E +K+ G L + R+ +N LD +V+ ++ V+ GI ++ ++
Sbjct: 944 YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKIL 1003
Query: 231 RVLRALKTVAIV---PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
RVLR L+ + + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 1004 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1059
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/173 (28%), Positives = 87/173 (50%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD+ I+L I N + + + S + + L+ + F++IF+ E LKI
Sbjct: 122 IVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKII 181
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DFV+V+ + S++L + ++ ++ +R
Sbjct: 182 AYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRA 241
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G ++ +L ++ ++ L +I LL+ V+ I+AI G+ F+
Sbjct: 242 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294
Score = 61.3 bits (142), Expect = 3e-08
Identities = 31/95 (32%), Positives = 56/95 (58%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG + F
Sbjct: 644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-----NF 698
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
+ R F +F + + VF++L GE W M+D
Sbjct: 699 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYD 733
Score = 47.2 bits (107), Expect = 6e-04
Identities = 41/187 (21%), Positives = 84/187 (44%), Gaps = 35/187 (18%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P NP + Y++ F + I++N + + M ++ ++FTG++T
Sbjct: 1210 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1269
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID----------------LG 222
E +KV+A +P Y DAWN D +++ + + + + G
Sbjct: 1270 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325
Query: 223 N--------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFA 274
N + R FRV+R +K ++ G++T++ I+S + L V +L ++A
Sbjct: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385
Query: 275 LMGLQIY 281
++G+Q++
Sbjct: 1386 VIGMQMF 1392
Score = 43.2 bits (97), Expect = 0.010
Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK + ++
Sbjct: 1344 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1403
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W E M C+
Sbjct: 1404 NRNN----NFQTFPQAVLLLFRCATGEAWQEIMLACL 1436
Score = 41.1 bits (92), Expect = 0.039
Identities = 31/118 (26%), Positives = 60/118 (50%), Gaps = 10/118 (8%)
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLGNLAAL--- 227
+ ++T E VK+ + G LQ Y +N D FVV T+ ++L ++ L
Sbjct: 581 VLLALFTCEMLVKMYSLG--LQ--AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGIS 636
Query: 228 --RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R R+LR K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 637 VFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 694
Score = 37.5 bits (83), Expect = 0.48
Identities = 16/57 (28%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF
Sbjct: 237 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
>AL022319-1|CAI19662.1| 2016|Homo sapiens calcium channel,
voltage-dependent, alpha 1I subunit protein.
Length = 2016
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1225
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1226 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1285
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1286 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1342
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1343 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1461 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1517
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1518 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1692
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1693 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 685
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 737
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 738 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 797
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 798 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 840
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 879
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 683
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 684 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 741
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 797
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 798 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 833
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 834 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 880
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1207
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 281 YMG 283
+ G
Sbjct: 1328 FKG 1330
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 730
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 790 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 821
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1594 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1651
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1688
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1488 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1525
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 405 MSY 407
+
Sbjct: 863 EGF 865
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
>AL022312-6|CAI19180.1| 2016|Homo sapiens calcium channel,
voltage-dependent, alpha 1I subunit protein.
Length = 2016
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1225
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1226 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1285
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1286 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1342
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1343 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1461 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1517
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1518 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1692
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1693 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 685
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 737
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 738 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 797
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 798 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 840
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 879
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 683
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 684 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 741
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 797
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 798 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 833
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 834 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 880
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1207
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 281 YMG 283
+ G
Sbjct: 1328 FKG 1330
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 730
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 790 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 821
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1594 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1651
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1688
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1488 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1525
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 405 MSY 407
+
Sbjct: 863 EGF 865
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
>AL008716-1|CAI17903.1| 2016|Homo sapiens calcium channel,
voltage-dependent, alpha 1I subunit protein.
Length = 2016
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1225
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1226 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1285
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1286 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1342
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1343 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1461 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1517
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1518 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1692
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1693 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 685
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 737
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 738 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 797
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 798 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 840
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 879
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 683
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 684 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 741
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 797
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 798 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 833
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 834 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 880
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1207
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 281 YMG 283
+ G
Sbjct: 1328 FKG 1330
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 730
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 790 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 821
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1594 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1651
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1688
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1488 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1525
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 405 MSY 407
+
Sbjct: 863 EGF 865
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
>AF393329-1|AAM67414.1| 2188|Homo sapiens voltage-dependent calcium
channel T-type alpha 1I subunit protein.
Length = 2188
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1131 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1190
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1191 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1250
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1251 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1307
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1308 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1425
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1426 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1482
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1483 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1541
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1542 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1601
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1602 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1657
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1658 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 591 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 650
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 651 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 702
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 703 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 762
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 763 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 805
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 806 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 591 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 648
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 649 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 706
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 707 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 762
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 763 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 798
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 799 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 845
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1172
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
Query: 281 YMG 283
+ G
Sbjct: 1293 FKG 1295
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 580 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 640 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 695
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 696 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 695 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 754
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 755 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 786
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1559 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1616
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1617 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1653
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1453 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1490
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 405 MSY 407
+
Sbjct: 828 EGF 830
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 641
>AF211189-1|AAF44626.1| 1981|Homo sapiens T-type calcium channel
alpha1 subunit Alpha1I-a isoform protein.
Length = 1981
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1131 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1190
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1191 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1250
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1251 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1307
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1308 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1425
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1426 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1482
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1483 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1541
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1542 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1601
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1602 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1657
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1658 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 591 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 650
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 651 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 702
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 703 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 762
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 763 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 805
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 806 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 844
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 591 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 648
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 649 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 706
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 707 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 762
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 763 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 798
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 799 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 845
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1172
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
Query: 281 YMG 283
+ G
Sbjct: 1293 FKG 1295
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 580 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 640 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 695
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 696 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 695 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 754
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 755 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 786
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1559 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1616
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1617 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1653
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1453 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1490
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 405 MSY 407
+
Sbjct: 828 EGF 830
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 641
>AF142567-1|AAF25722.1| 2223|Homo sapiens T calcium channel alpha1I
subunit, delta36B splice variant protein.
Length = 2223
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1225
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1226 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1285
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1286 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1342
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1343 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1461 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1517
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1518 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1692
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1693 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 685
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 737
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 738 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 797
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 798 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 840
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 879
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 683
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 684 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 741
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 797
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 798 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 833
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 834 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 880
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1207
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 281 YMG 283
+ G
Sbjct: 1328 FKG 1330
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 730
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 790 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 821
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1594 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1651
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1688
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1488 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1525
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 405 MSY 407
+
Sbjct: 863 EGF 865
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
>AF129133-1|AAD45251.1| 2016|Homo sapiens T-type calcium channel
alpha1I subunit protein.
Length = 2016
Score = 314 bits (770), Expect = 3e-84
Identities = 178/592 (30%), Positives = 319/592 (53%), Gaps = 31/592 (5%)
Query: 1214 LIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLA 1273
+I + F+ V+ I L+ + +ALE + + L + IFT IF EM +K ++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVS 1225
Query: 1274 LGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRALRPLRA 1326
LG Q Y ++W LD +V VS+I+ V +L AGG + + +R LR LRPLR
Sbjct: 1226 LGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRV 1285
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C+ ++
Sbjct: 1286 ISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRN--- 1342
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
I +++ C NY W + NFD++G+A + LF +A+ GW+ IM + +D+ V +QP+
Sbjct: 1343 --ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAM 1506
N +M LY LN+F+GV+++NF++ ++ E + +
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
Query: 1507 KKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA 1566
++ + P A + ++ + T D+ I I LN++TM+L+HY Q +
Sbjct: 1461 RRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1517
Query: 1567 VLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVMFSILSLVLSDI-IEKY 1623
L Y N +F +F E +LK+ F LR +F + WN D +V+ S++ + L +I I
Sbjct: 1518 ALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 1624 F-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIF 1682
++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FI+A
Sbjct: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
Query: 1683 GMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLP 1737
G+ F + D+ G+ F+ F + + LFQ+ST W+G++ + D
Sbjct: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR----DCT 1692
Query: 1738 DNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ER + + Y +S+++ + ++IN+ +AV++++ + ++ QE
Sbjct: 1693 HDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 99.5 bits (237), Expect = 1e-19
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 33/280 (11%)
Query: 1523 WRP-QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR +A + IV K F+ IM+ I +N ++M ++H++Q E + +L+ N++F +F+
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFAL 685
Query: 1582 ECLLKIFAL-RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E +LK+ A + Y P+N+FD ++V+ SI +V + L V+R ++ R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--------ADGGLSVLRTFRLLR 737
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF-----MHVKDKGG 1695
VL+LV+ +R L L ++ + C+LL L +FIF+I GM F +
Sbjct: 738 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT 797
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
+ D NF + + +++ +FQ+ T W+ VL G ++
Sbjct: 798 VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN-----------------GMASTSPWASL 840
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDD 1795
Y ++ + ++ N+ +A+++E + QA D +D+D
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGF-QAEGDANRSYSDED 879
Score = 97.5 bits (232), Expect = 4e-19
Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQD---ILYYMDRIFTVIFFIEMLI 1269
K++ N +FE + +ILL+ + L + L D IL D + F +EM++
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMYQP-CDDMDCLSDRCKILQVFDDFIFIFFAMEMVL 132
Query: 1270 KWLALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
K +ALG F K Y + W LDF IVM ++ + L +RT+R LRPL+A
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKA 188
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
++R+ MR++VN L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 189 INRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.6 bits (205), Expect = 8e-16
Identities = 70/296 (23%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 1204 WGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIF 1263
W R K ++++ YF ++ IL++++++ +E P L +IL + +FT +F
Sbjct: 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE--LTNILEICNVVFTSMF 683
Query: 1264 FIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+EM++K A G Y N + D IIV++S+ V GG+ +T R LR L+
Sbjct: 684 ALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKL 741
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
+R M ++ VV L++ + ++ ++ ++F IF+I+G+ +F K+ D T
Sbjct: 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDT- 797
Query: 1384 LSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGR 1443
+PD+ NFD + A + +FQ+ T + W ++ + + S
Sbjct: 798 -----VPDRK--------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----- 833
Query: 1444 QPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQ 1499
T+ + LY NL + ++++ F + G + + EDQ
Sbjct: 834 -----TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE----GDANRSYSDEDQ 880
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
++++ P N R + I+ H LF ++ I +NCI + + P +E STE
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVS 1207
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGID 220
IFT I+ E +KV++ G YLR +WN LD FV V++LA
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q+
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 281 YMG 283
+ G
Sbjct: 1328 FKG 1330
Score = 83.0 bits (196), Expect = 1e-14
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 14/172 (8%)
Query: 131 RRVAIYILVHPLFSLFIITTILVNCIL--MIMPT------TPTVESTEVIFTGIYTF--- 179
R I ++ +P F + IL+NC+ M P + + +V I+ F
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--LAALRTFRVLRALK 237
E +K++A G I YL D WN LDF ++ V +DL N L+A+RT RVLR LK
Sbjct: 129 EMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query: 238 TVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
+ VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRC 239
Score = 71.7 bits (168), Expect = 2e-11
Identities = 49/174 (28%), Positives = 91/174 (52%), Gaps = 13/174 (7%)
Query: 117 ATNALWIL-DPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP-------TTPTVES 168
A A+W+ D + R I+ F+ I+ ILVN + M + T +E
Sbjct: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
Query: 169 TEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDLGNLAAL 227
V+FT ++ E +K+ A G F YLR+ +N D +++ ++ + +G G L+ L
Sbjct: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVL 730
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
RTFR+LR LK V +P L+ + +++++ N+ +L M + +F+++G+ I+
Sbjct: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 60.1 bits (139), Expect = 8e-08
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 19/173 (10%)
Query: 1525 PQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMI-----FIVIF 1579
P+ ++V + F+ + ML I LN +T+ + YQ + + D ++ FI IF
Sbjct: 68 PRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIF 125
Query: 1580 -SSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ AL + Y + WN DF +VM ++ L + L +R
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIR 178
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R L+ + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 179 TVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNY- 885
L++ LRV KL + P L + ++ +TM + +L + IFIF+++GM +FG +
Sbjct: 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query: 886 --VDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE 919
D D PD R NF + + + VF++L E
Sbjct: 790 LRTDTGDTVPD----RKNFDSLLWAIVTVFQILTQE 821
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
N C + +NFD++G A++ +FQV T +GW++IM +D+ + Y
Sbjct: 324 NVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFY 373
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1505
++Y +NL + VI F+E K++ M E +++Y ++
Sbjct: 374 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE----HRLMLEQRQRYLSS 422
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/78 (30%), Positives = 46/78 (58%), Gaps = 12/78 (15%)
Query: 341 VCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYW-ENLYQ----------LFFVVIIF 389
VC G NP+ G +FD G+A++ F+++T + W E +Y ++F+++I
Sbjct: 325 VCRTG-SANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLII 383
Query: 390 LGSFYLVNLILAIVAMSY 407
+GSF+++NL L ++A +
Sbjct: 384 VGSFFMINLCLVVIATQF 401
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 1594 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 1651
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 1688
Score = 39.1 bits (87), Expect = 0.16
Identities = 16/56 (28%), Positives = 34/56 (60%)
Query: 826 ALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
A+++ LR K P++ +L++++ T+ LGN+ + + FIF ++G+QL+
Sbjct: 176 AIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 1488 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 1525
Score = 35.9 bits (79), Expect = 1.5
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWE-NLY----------QLFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+FV ++ G++ L NL++AI+
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 405 MSY 407
+
Sbjct: 863 EGF 865
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/58 (27%), Positives = 30/58 (51%)
Query: 774 VWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGN 831
VW C +W E + + +V + I + I+VNT+ M ++HH +++ L+ N
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
>DQ363529-1|ABC88012.1| 1099|Homo sapiens low-voltage-activated
calcium channel alpha1H subunit splice variant 577
protein.
Length = 1099
Score = 313 bits (769), Expect = 4e-84
Identities = 184/638 (28%), Positives = 338/638 (52%), Gaps = 45/638 (7%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
R+ K+I + F+ V+ I L+ + +ALE + + L + IFT IF EM
Sbjct: 25 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 84
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---AFKTMRTLRA 1320
++K +ALG Y ++W LD ++V+VSL++ V A+ AGG + + +R LR
Sbjct: 85 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 144
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF GK++ C +
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 204
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
+S K C +Y W NFD++G+A + LF +++ GW+ IM D +D+
Sbjct: 205 TRNIS-----TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 259
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QP++ N +M LY LN+F+GV+++NF+ K + E ++K
Sbjct: 260 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRREEK 317
Query: 1501 KYYNAMKKMGSKK-PLK-AIPRPRWRP--------QAIVFEIVTDKKFDMIIMLFIGLNM 1550
+ ++ SK P+ A+ + RP + + + T D+ I I +N+
Sbjct: 318 RLRRLERRRRSKALPVAVAVAEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNV 377
Query: 1551 LTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMF 1609
+TM+++HY Q ++ L Y N +F ++F E LK+ A + +F + WN D +V+
Sbjct: 378 ITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLL 437
Query: 1610 SILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1667
S++ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N
Sbjct: 438 SLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 497
Query: 1668 ICLLLFLVMFIFAIFGMSFFMHVKDK-----GGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
+ LL L+ FI+A G+ F ++ GL F F + + LF++ST W+
Sbjct: 498 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN 557
Query: 1723 GVLDGIINEEECDLPDNERGSPGNCGS--ATIGITYLLSYLVISFLIVINMYIAVILENY 1780
G++ + EC D +C S + Y +++++++ +++N+ +AV++++
Sbjct: 558 GIMKDTL--RECSREDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHL 609
Query: 1781 SQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQ 1818
++ ++ +E D + D E+ P ++ + D+
Sbjct: 610 EESNKEARE---DAELDAEIELEMAQGPGSARRVDADR 644
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/183 (27%), Positives = 95/183 (51%), Gaps = 20/183 (10%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVE--STE------- 170
AL++ P N R ++ H +F ++ I +NC+ + + P ++ STE
Sbjct: 14 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVS 72
Query: 171 -VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
IFT I+ E VKV+A G + YL+ +WN LD +++ ++ V + +
Sbjct: 73 NYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKI 132
Query: 221 LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 280
LG L LR R LR L+ ++ PGLK +V +I S++ + +++++ +F ++G+Q+
Sbjct: 133 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 192
Query: 281 YMG 283
+ G
Sbjct: 193 FKG 195
Score = 59.3 bits (137), Expect = 1e-07
Identities = 40/173 (23%), Positives = 86/173 (49%), Gaps = 22/173 (12%)
Query: 127 FNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYTF 179
++P RR + LFI I VN I M M +S + +FT ++ F
Sbjct: 349 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 408
Query: 180 ESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA-----------LR 228
E+A+K++A GF + +D WN LD ++ L+ + + ++ ++A +R
Sbjct: 409 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 464
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
R+ R LK + + G++ ++ V++++ + ++ +L M ++A +G++++
Sbjct: 465 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 517
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/97 (29%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFG+ ++ + P
Sbjct: 470 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--LECSEDNP 527
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F++F +F+ +FRV G+ W M D +
Sbjct: 528 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTL 564
Score = 43.6 bits (98), Expect = 0.007
Identities = 17/38 (44%), Positives = 28/38 (73%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
+++LFIT I VN + M+++H+N K +D+ALK NY+
Sbjct: 364 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYV 401
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 145 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 198
>AY682086-1|AAT85835.1| 539|Homo sapiens voltage-gated sodium
channel Nav1.7 protein.
Length = 539
Score = 313 bits (769), Expect = 4e-84
Identities = 163/275 (59%), Positives = 201/275 (73%), Gaps = 23/275 (8%)
Query: 151 ILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV 209
IL NCI M M P ++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDFVV
Sbjct: 1 ILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 60
Query: 210 IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFS 269
I AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F
Sbjct: 61 IVFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFC 120
Query: 270 LSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETN-----WYGEGG-D 323
LSVFAL+GLQ++MG L KC + E+ N T E+ ++E + +Y EG D
Sbjct: 121 LSVFALIGLQLFMGNLKHKCFRNSLEN----NETLESIMNTLESEEDFRRYFYYLEGSKD 176
Query: 324 YPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-- 381
LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ FRLMTQDYWENLYQ
Sbjct: 177 ALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQT 235
Query: 382 ---------LFFVVIIFLGSFYLVNLILAIVAMSY 407
+FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 236 LRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 270
Score = 73.7 bits (173), Expect = 6e-12
Identities = 40/123 (32%), Positives = 71/123 (57%), Gaps = 11/123 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K LA GF + + W WLDF++++ + +V G + A +T
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YVTEFVDLGNVSALRT 80
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 81 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 137
Query: 1374 FKC 1376
KC
Sbjct: 138 HKC 140
Score = 53.2 bits (122), Expect = 9e-06
Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 1575 FIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DFVV++F+ ++ FV
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYVT---------EFVDLGN 74
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM- 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 75 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 134
Query: 1689 HVKDKGGLDDVYNFKTFVQSM 1709
++K K + + N +T M
Sbjct: 135 NLKHKCFRNSLENNETLESIM 155
>AY682084-1|AAT85833.1| 528|Homo sapiens voltage-gated sodium
channel Nav1.7 protein.
Length = 528
Score = 313 bits (769), Expect = 4e-84
Identities = 163/275 (59%), Positives = 201/275 (73%), Gaps = 23/275 (8%)
Query: 151 ILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV 209
IL NCI M M P ++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDFVV
Sbjct: 1 ILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 60
Query: 210 IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFS 269
I AYVT +DLGN++ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F
Sbjct: 61 IVFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFC 120
Query: 270 LSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETN-----WYGEGG-D 323
LSVFAL+GLQ++MG L KC + E+ N T E+ ++E + +Y EG D
Sbjct: 121 LSVFALIGLQLFMGNLKHKCFRNSLEN----NETLESIMNTLESEEDFRKYFYYLEGSKD 176
Query: 324 YPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-- 381
LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ FRLMTQDYWENLYQ
Sbjct: 177 ALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQT 235
Query: 382 ---------LFFVVIIFLGSFYLVNLILAIVAMSY 407
+FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 236 LRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 270
Score = 73.7 bits (173), Expect = 6e-12
Identities = 40/123 (32%), Positives = 71/123 (57%), Gaps = 11/123 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K LA GF + + W WLDF++++ + +V G + A +T
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YVTEFVDLGNVSALRT 80
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 81 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 137
Query: 1374 FKC 1376
KC
Sbjct: 138 HKC 140
Score = 53.2 bits (122), Expect = 9e-06
Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 1575 FIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DFVV++F+ ++ FV
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYVT---------EFVDLGN 74
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM- 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 75 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 134
Query: 1689 HVKDKGGLDDVYNFKTFVQSM 1709
++K K + + N +T M
Sbjct: 135 NLKHKCFRNSLENNETLESIM 155
>AJ224874-1|CAA12175.1| 1966|Homo sapiens L-type calcium channel
alpha-1 subunit protein.
Length = 1966
Score = 313 bits (769), Expect = 4e-84
Identities = 207/670 (30%), Positives = 352/670 (52%), Gaps = 43/670 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR LI + F ++ I+LSS++LA ED H IL Y D FT IF +E
Sbjct: 849 LRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS-FRNHILGYFDYAFTSIFTVE 907
Query: 1267 MLIKWLALG---FQKYFTNAWC-WLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G + F +W LD ++V VSLI+F + I K +R LR LR
Sbjct: 908 ILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH---SSAISVVKILRVLRVLR 964
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD-MNH 1381
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK++ C D H
Sbjct: 965 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKH 1024
Query: 1382 TTL----SHEIIPDKNAC--TLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T S + PD + + W NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1025 TPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1084
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
ID+ PI + + ++ +N+F+G +I F Q ++ + E+
Sbjct: 1085 IDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDK 1144
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ Q Y A+K +PL+ P+ Q V+ V F+ ++ L I LN + + +
Sbjct: 1145 NQRQCVEY-ALK----AQPLRRY-IPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1198
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSL 1614
HY+Q+ F+ +D LNM+F +F+ E +LKI A + HYF + WN FD ++V+ SI+ +
Sbjct: 1199 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1258
Query: 1615 VLSDIIEKYFV-------SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1667
++++ + S + R+ +V R+++L+ +GIRTLL+ S AL
Sbjct: 1259 AVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPY 1318
Query: 1668 ICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
+ LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T W ++
Sbjct: 1319 VALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1378
Query: 1726 DGIINEEECDLPDNERGSPG---NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQ 1782
+ CD P+++ G PG CGS I Y +S+ ++ ++IN+++AVI++N+
Sbjct: 1379 LASLPGNRCD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDY 1435
Query: 1783 ATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY-- 1838
T D L D + IW +DP I++ + L ++PPL K P++
Sbjct: 1436 LTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVAC 1494
Query: 1839 -KIISMDIPI 1847
++++M++P+
Sbjct: 1495 KRLVAMNMPL 1504
Score = 123 bits (297), Expect = 6e-27
Identities = 88/324 (27%), Positives = 162/324 (50%), Gaps = 61/324 (18%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVEST 169
AL+ L NP+RR I I+ F + I+ TI NC+ + +P +E
Sbjct: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLG------- 222
E +F I+T E+ +K++A G +L P Y+R+ WN LDF+++ + ++ ++ G
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 223 ----------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
++ ALR FRVLR L+ V+ VP L ++ ++++++ L + +L +F + +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C + GS D E D C +S
Sbjct: 251 YAIIGLELFLGRMHKTCYFL----GS-----DMEAEE-------------DPSPCASSGS 288
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL- 382
C +G P PN G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 --FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLS 372
Score = 87.4 bits (207), Expect = 5e-16
Identities = 82/313 (26%), Positives = 141/313 (45%), Gaps = 43/313 (13%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRP--ILQDILYYMDRIFTVIFF 1264
LR ++E F+ ++ I + +AL + + P L ++ +F VIF
Sbjct: 81 LRRSCISIVEWKPFDILILLTIFANCVALGVY-IPFPEDDSNTANHNLEQVEYVFLVIFT 139
Query: 1265 IEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV----------AALCGA--GG 1308
+E ++K +A G Y N W LDFIIV+V L + + A G GG
Sbjct: 140 VETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199
Query: 1309 IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQL 1368
K +R R LRPLR +S + + +V+N++++A+ + ++ L+ L +I+AI+G++L
Sbjct: 200 FDV-KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 1369 FAGKYFKCVDMNHTTLSHEIIPDK-------NACTLENY----TW---ENSPMNFDHVGK 1414
F G+ K + + E P ACTL W NFD+
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFF 318
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
A L +FQ T +GW ++ D+ +G + ++Y LNL +G
Sbjct: 319 AMLTVFQCVTMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLG 369
Query: 1475 VIIDNFNEQKKKA 1487
V+ F+++++KA
Sbjct: 370 VLSGEFSKEREKA 382
Score = 87.4 bits (207), Expect = 5e-16
Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 12/194 (6%)
Query: 1542 IMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-N 1600
++L + LN LT+ +H+ Q + + +Y N + + +F+ E LLK++ L +V + N
Sbjct: 524 VLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFN 583
Query: 1601 LFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1660
FD VV IL L +E + P + V+R ++ R+ ++ + + L+ +L
Sbjct: 584 RFDCFVVCGGILETTL---VEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLN 640
Query: 1661 SLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILLFQMS 1716
S+ ++ ++ LLLFL + IF++ GM F K D + F TF Q+++ +FQ+
Sbjct: 641 SMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDQTHTKRSTFDTFPQALLTVFQIL 697
Query: 1717 TSAGWDGVL-DGII 1729
T W+ V+ DGI+
Sbjct: 698 TGEDWNVVMYDGIM 711
Score = 73.7 bits (173), Expect = 6e-12
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 30/273 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + + +++ AV+ ++ L++L +A E H L I Y +++ +F +E
Sbjct: 507 LRARCRRAVKSNACYWAVLLLVFLNTLTIASE--HHGQPVWLTQIQEYANKVLLCLFTVE 564
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
ML+K LG Y ++ + D +V ++ GA +R +R LR +
Sbjct: 565 MLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKV 624
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+ +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+ D HT S
Sbjct: 625 TRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDQTHTKRS- 681
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
FD +A L +FQ+ T + W +M D I + P
Sbjct: 682 ---------------------TFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFP- 719
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDN 1479
+ + +Y LN+F+ + +DN
Sbjct: 720 ---GMLVCIYFIILFICGNYILLNVFLAIAVDN 749
Score = 71.7 bits (168), Expect = 2e-11
Identities = 44/176 (25%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
+A + L NP+R+ ++ H +F+ I+ I+++ + + S +
Sbjct: 838 SAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFD 897
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
FT I+T E +K+ G L ++ R +N LD +V++++ ++ GI ++ L
Sbjct: 898 YAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKIL 957
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 958 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1013
Score = 69.7 bits (163), Expect = 1e-10
Identities = 53/173 (30%), Positives = 89/173 (51%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD++I+L I N + + + S T + L+ + +F+VIF+ E +LKI
Sbjct: 88 IVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIV 147
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DF++V+ + S++L + +P ++ +R
Sbjct: 148 AYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRA 207
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G + +L ++ +L L +I LL+ V+ I+AI G+ F+
Sbjct: 208 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 260
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/101 (31%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG +
Sbjct: 613 LRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF- 671
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F R F F + + VF++L GE W M+D
Sbjct: 672 ----NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYD 708
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 27/168 (16%)
Query: 143 FSLFIITTILVNCILMIMP----TTP---TVESTEVIFTGIYTFESAVKVMARGFILQPF 195
F + IL+N + + M T P ++ ++FTG++T E +K++A +P
Sbjct: 1181 FEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FKPK 1236
Query: 196 TYLRDAWNWLDFVV-------IALAYVTMGIDLG---------NLAALRTFRVLRALKTV 239
Y DAWN D ++ IA+ V G LG ++ R FRV+R +K +
Sbjct: 1237 HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLL 1296
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 287
+ G++T++ I+S + L V +L ++A++G+Q++ V Q
Sbjct: 1297 SKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQ 1344
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/107 (25%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 183 VKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLG-----NLAALRTFRVLRAL 236
V+++ + + L P Y+ +N D FVV T +++G ++ LR R+LR
Sbjct: 563 VEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIF 622
Query: 237 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 623 KVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 669
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ +I FI+AV+GMQ+FGK + +
Sbjct: 1290 MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQI 1349
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESM 924
+ NF F + +++FR GE W E M
Sbjct: 1350 NRNN----NFQTFPQAVLLLFRCATGEAWQEIM 1378
Score = 37.5 bits (83), Expect = 0.48
Identities = 15/57 (26%), Positives = 37/57 (64%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L+++++ + + + L ++ ++ +I I+A++G++LF
Sbjct: 203 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 259
>AJ006216-1|CAA06916.1| 1966|Homo sapiens L-type calcium channel
alpha-1 subunit protein.
Length = 1966
Score = 313 bits (769), Expect = 4e-84
Identities = 207/670 (30%), Positives = 352/670 (52%), Gaps = 43/670 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR LI + F ++ I+LSS++LA ED H IL Y D FT IF +E
Sbjct: 849 LRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS-FRNHILGYFDYAFTSIFTVE 907
Query: 1267 MLIKWLALG---FQKYFTNAWC-WLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G + F +W LD ++V VSLI+F + I K +R LR LR
Sbjct: 908 ILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH---SSAISVVKILRVLRVLR 964
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD-MNH 1381
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK++ C D H
Sbjct: 965 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKH 1024
Query: 1382 TTL----SHEIIPDKNAC--TLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T S + PD + + W NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1025 TPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1084
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
ID+ PI + + ++ +N+F+G +I F Q ++ + E+
Sbjct: 1085 IDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDK 1144
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ Q Y A+K +PL+ P+ Q V+ V F+ ++ L I LN + + +
Sbjct: 1145 NQRQCVEY-ALK----AQPLRRY-IPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1198
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSL 1614
HY+Q+ F+ +D LNM+F +F+ E +LKI A + HYF + WN FD ++V+ SI+ +
Sbjct: 1199 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1258
Query: 1615 VLSDIIEKYFV-------SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1667
++++ + S + R+ +V R+++L+ +GIRTLL+ S AL
Sbjct: 1259 AVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPY 1318
Query: 1668 ICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
+ LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T W ++
Sbjct: 1319 VALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1378
Query: 1726 DGIINEEECDLPDNERGSPG---NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQ 1782
+ CD P+++ G PG CGS I Y +S+ ++ ++IN+++AVI++N+
Sbjct: 1379 LASLPGNRCD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDY 1435
Query: 1783 ATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY-- 1838
T D L D + IW +DP I++ + L ++PPL K P++
Sbjct: 1436 LTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVAC 1494
Query: 1839 -KIISMDIPI 1847
++++M++P+
Sbjct: 1495 KRLVAMNMPL 1504
Score = 123 bits (297), Expect = 6e-27
Identities = 88/324 (27%), Positives = 162/324 (50%), Gaps = 61/324 (18%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVEST 169
AL+ L NP+RR I I+ F + I+ TI NC+ + +P +E
Sbjct: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLG------- 222
E +F I+T E+ +K++A G +L P Y+R+ WN LDF+++ + ++ ++ G
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 223 ----------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
++ ALR FRVLR L+ V+ VP L ++ ++++++ L + +L +F + +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C + GS D E D C +S
Sbjct: 251 YAIIGLELFLGRMHKTCYFL----GS-----DMEAEE-------------DPSPCASSGS 288
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL- 382
C +G P PN G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 --FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLS 372
Score = 87.4 bits (207), Expect = 5e-16
Identities = 82/313 (26%), Positives = 141/313 (45%), Gaps = 43/313 (13%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRP--ILQDILYYMDRIFTVIFF 1264
LR ++E F+ ++ I + +AL + + P L ++ +F VIF
Sbjct: 81 LRRSCISIVEWKPFDILILLTIFANCVALGVY-IPFPEDDSNTANHNLEQVEYVFLVIFT 139
Query: 1265 IEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV----------AALCGA--GG 1308
+E ++K +A G Y N W LDFIIV+V L + + A G GG
Sbjct: 140 VETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199
Query: 1309 IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQL 1368
K +R R LRPLR +S + + +V+N++++A+ + ++ L+ L +I+AI+G++L
Sbjct: 200 FDV-KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 1369 FAGKYFKCVDMNHTTLSHEIIPDK-------NACTLENY----TW---ENSPMNFDHVGK 1414
F G+ K + + E P ACTL W NFD+
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFF 318
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
A L +FQ T +GW ++ D+ +G + ++Y LNL +G
Sbjct: 319 AMLTVFQCVTMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLG 369
Query: 1475 VIIDNFNEQKKKA 1487
V+ F+++++KA
Sbjct: 370 VLSGEFSKEREKA 382
Score = 87.4 bits (207), Expect = 5e-16
Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 12/194 (6%)
Query: 1542 IMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-N 1600
++L + LN LT+ +H+ Q + + +Y N + + +F+ E LLK++ L +V + N
Sbjct: 524 VLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFN 583
Query: 1601 LFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1660
FD VV IL L +E + P + V+R ++ R+ ++ + + L+ +L
Sbjct: 584 RFDCFVVCGGILETTL---VEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLN 640
Query: 1661 SLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILLFQMS 1716
S+ ++ ++ LLLFL + IF++ GM F K D + F TF Q+++ +FQ+
Sbjct: 641 SMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDQTHTKRSTFDTFPQALLTVFQIL 697
Query: 1717 TSAGWDGVL-DGII 1729
T W+ V+ DGI+
Sbjct: 698 TGEDWNVVMYDGIM 711
Score = 73.7 bits (173), Expect = 6e-12
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 30/273 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + + +++ AV+ ++ L++L +A E H L I Y +++ +F +E
Sbjct: 507 LRARCRRAVKSNACYWAVLLLVFLNTLTIASE--HHGQPVWLTQIQEYANKVLLCLFTVE 564
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
ML+K LG Y ++ + D +V ++ GA +R +R LR +
Sbjct: 565 MLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKV 624
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+ +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+ D HT S
Sbjct: 625 TRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDQTHTKRS- 681
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
FD +A L +FQ+ T + W +M D I + P
Sbjct: 682 ---------------------TFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFP- 719
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDN 1479
+ + +Y LN+F+ + +DN
Sbjct: 720 ---GMLVCIYFIILFICGNYILLNVFLAIAVDN 749
Score = 71.7 bits (168), Expect = 2e-11
Identities = 44/176 (25%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
+A + L NP+R+ ++ H +F+ I+ I+++ + + S +
Sbjct: 838 SAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFD 897
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
FT I+T E +K+ G L ++ R +N LD +V++++ ++ GI ++ L
Sbjct: 898 YAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKIL 957
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 958 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1013
Score = 69.7 bits (163), Expect = 1e-10
Identities = 53/173 (30%), Positives = 89/173 (51%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD++I+L I N + + + S T + L+ + +F+VIF+ E +LKI
Sbjct: 88 IVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIV 147
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DF++V+ + S++L + +P ++ +R
Sbjct: 148 AYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRA 207
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G + +L ++ +L L +I LL+ V+ I+AI G+ F+
Sbjct: 208 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 260
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/101 (31%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG +
Sbjct: 613 LRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF- 671
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F R F F + + VF++L GE W M+D
Sbjct: 672 ----NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYD 708
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 27/168 (16%)
Query: 143 FSLFIITTILVNCILMIMP----TTP---TVESTEVIFTGIYTFESAVKVMARGFILQPF 195
F + IL+N + + M T P ++ ++FTG++T E +K++A +P
Sbjct: 1181 FEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FKPK 1236
Query: 196 TYLRDAWNWLDFVV-------IALAYVTMGIDLG---------NLAALRTFRVLRALKTV 239
Y DAWN D ++ IA+ V G LG ++ R FRV+R +K +
Sbjct: 1237 HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLL 1296
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 287
+ G++T++ I+S + L V +L ++A++G+Q++ V Q
Sbjct: 1297 SKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQ 1344
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/107 (25%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 183 VKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLG-----NLAALRTFRVLRAL 236
V+++ + + L P Y+ +N D FVV T +++G ++ LR R+LR
Sbjct: 563 VEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIF 622
Query: 237 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 623 KVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 669
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ +I FI+AV+GMQ+FGK + +
Sbjct: 1290 MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQI 1349
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESM 924
+ NF F + +++FR GE W E M
Sbjct: 1350 NRNN----NFQTFPQAVLLLFRCATGEAWQEIM 1378
Score = 37.5 bits (83), Expect = 0.48
Identities = 15/57 (26%), Positives = 37/57 (64%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L+++++ + + + L ++ ++ +I I+A++G++LF
Sbjct: 203 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 259
>AF201304-1|AAF15290.1| 1977|Homo sapiens voltage-gated L-type calcium
channel alpha-1 subunit protein.
Length = 1977
Score = 313 bits (769), Expect = 4e-84
Identities = 207/670 (30%), Positives = 352/670 (52%), Gaps = 43/670 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR LI + F ++ I+LSS++LA ED H IL Y D FT IF +E
Sbjct: 860 LRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS-FRNHILGYFDYAFTSIFTVE 918
Query: 1267 MLIKWLALG---FQKYFTNAWC-WLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G + F +W LD ++V VSLI+F + I K +R LR LR
Sbjct: 919 ILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH---SSAISVVKILRVLRVLR 975
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD-MNH 1381
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK++ C D H
Sbjct: 976 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKH 1035
Query: 1382 TTL----SHEIIPDKNAC--TLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T S + PD + + W NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1036 TPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1095
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
ID+ PI + + ++ +N+F+G +I F Q ++ + E+
Sbjct: 1096 IDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDK 1155
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ Q Y A+K +PL+ P+ Q V+ V F+ ++ L I LN + + +
Sbjct: 1156 NQRQCVEY-ALK----AQPLRRY-IPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1209
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSL 1614
HY+Q+ F+ +D LNM+F +F+ E +LKI A + HYF + WN FD ++V+ SI+ +
Sbjct: 1210 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1269
Query: 1615 VLSDIIEKYFV-------SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1667
++++ + S + R+ +V R+++L+ +GIRTLL+ S AL
Sbjct: 1270 AVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPY 1329
Query: 1668 ICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
+ LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T W ++
Sbjct: 1330 VALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1389
Query: 1726 DGIINEEECDLPDNERGSPG---NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQ 1782
+ CD P+++ G PG CGS I Y +S+ ++ ++IN+++AVI++N+
Sbjct: 1390 LASLPGNRCD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDY 1446
Query: 1783 ATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY-- 1838
T D L D + IW +DP I++ + L ++PPL K P++
Sbjct: 1447 LTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVAC 1505
Query: 1839 -KIISMDIPI 1847
++++M++P+
Sbjct: 1506 KRLVAMNMPL 1515
Score = 123 bits (297), Expect = 6e-27
Identities = 88/324 (27%), Positives = 162/324 (50%), Gaps = 61/324 (18%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVEST 169
AL+ L NP+RR I I+ F + I+ TI NC+ + +P +E
Sbjct: 71 ALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV 130
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLG------- 222
E +F I+T E+ +K++A G +L P Y+R+ WN LDF+++ + ++ ++ G
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 223 ----------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
++ ALR FRVLR L+ V+ VP L ++ ++++++ L + +L +F + +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII 250
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C + GS D E D C +S
Sbjct: 251 YAIIGLELFLGRMHKTCYFL----GS-----DMEAEE-------------DPSPCASSGS 288
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL- 382
C +G P PN G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 289 GRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP 348
Query: 383 --FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 349 WVYFVSLVIFGSFFVLNLVLGVLS 372
Score = 87.4 bits (207), Expect = 5e-16
Identities = 82/313 (26%), Positives = 141/313 (45%), Gaps = 43/313 (13%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRP--ILQDILYYMDRIFTVIFF 1264
LR ++E F+ ++ I + +AL + + P L ++ +F VIF
Sbjct: 81 LRRSCISIVEWKPFDILILLTIFANCVALGVY-IPFPEDDSNTANHNLEQVEYVFLVIFT 139
Query: 1265 IEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV----------AALCGA--GG 1308
+E ++K +A G Y N W LDFIIV+V L + + A G GG
Sbjct: 140 VETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199
Query: 1309 IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQL 1368
K +R R LRPLR +S + + +V+N++++A+ + ++ L+ L +I+AI+G++L
Sbjct: 200 FDV-KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
Query: 1369 FAGKYFKCVDMNHTTLSHEIIPDK-------NACTLENY----TW---ENSPMNFDHVGK 1414
F G+ K + + E P ACTL W NFD+
Sbjct: 259 FLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFF 318
Query: 1415 AYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIG 1474
A L +FQ T +GW ++ D+ +G + ++Y LNL +G
Sbjct: 319 AMLTVFQCVTMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLG 369
Query: 1475 VIIDNFNEQKKKA 1487
V+ F+++++KA
Sbjct: 370 VLSGEFSKEREKA 382
Score = 87.4 bits (207), Expect = 5e-16
Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 12/194 (6%)
Query: 1542 IMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-N 1600
++L + LN LT+ +H+ Q + + +Y N + + +F+ E LLK++ L +V + N
Sbjct: 535 VLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFN 594
Query: 1601 LFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1660
FD VV IL L +E + P + V+R ++ R+ ++ + + L+ +L
Sbjct: 595 RFDCFVVCGGILETTL---VEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLN 651
Query: 1661 SLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILLFQMS 1716
S+ ++ ++ LLLFL + IF++ GM F K D + F TF Q+++ +FQ+
Sbjct: 652 SMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDQTHTKRSTFDTFPQALLTVFQIL 708
Query: 1717 TSAGWDGVL-DGII 1729
T W+ V+ DGI+
Sbjct: 709 TGEDWNVVMYDGIM 722
Score = 73.7 bits (173), Expect = 6e-12
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 30/273 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + + +++ AV+ ++ L++L +A E H L I Y +++ +F +E
Sbjct: 518 LRARCRRAVKSNACYWAVLLLVFLNTLTIASE--HHGQPVWLTQIQEYANKVLLCLFTVE 575
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
ML+K LG Y ++ + D +V ++ GA +R +R LR +
Sbjct: 576 MLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKV 635
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+ +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+ D HT S
Sbjct: 636 TRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDQTHTKRS- 692
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
FD +A L +FQ+ T + W +M D I + P
Sbjct: 693 ---------------------TFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFP- 730
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDN 1479
+ + +Y LN+F+ + +DN
Sbjct: 731 ---GMLVCIYFIILFICGNYILLNVFLAIAVDN 760
Score = 71.7 bits (168), Expect = 2e-11
Identities = 44/176 (25%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
+A + L NP+R+ ++ H +F+ I+ I+++ + + S +
Sbjct: 849 SAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFD 908
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
FT I+T E +K+ G L ++ R +N LD +V++++ ++ GI ++ L
Sbjct: 909 YAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKIL 968
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 969 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1024
Score = 69.7 bits (163), Expect = 1e-10
Identities = 53/173 (30%), Positives = 89/173 (51%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD++I+L I N + + + S T + L+ + +F+VIF+ E +LKI
Sbjct: 88 IVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIV 147
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DF++V+ + S++L + +P ++ +R
Sbjct: 148 AYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRA 207
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G + +L ++ +L L +I LL+ V+ I+AI G+ F+
Sbjct: 208 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 260
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/101 (31%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG +
Sbjct: 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF- 682
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F R F F + + VF++L GE W M+D
Sbjct: 683 ----NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYD 719
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 27/168 (16%)
Query: 143 FSLFIITTILVNCILMIMP----TTP---TVESTEVIFTGIYTFESAVKVMARGFILQPF 195
F + IL+N + + M T P ++ ++FTG++T E +K++A +P
Sbjct: 1192 FEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FKPK 1247
Query: 196 TYLRDAWNWLDFVV-------IALAYVTMGIDLG---------NLAALRTFRVLRALKTV 239
Y DAWN D ++ IA+ V G LG ++ R FRV+R +K +
Sbjct: 1248 HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLL 1307
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 287
+ G++T++ I+S + L V +L ++A++G+Q++ V Q
Sbjct: 1308 SKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQ 1355
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/107 (25%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 183 VKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLG-----NLAALRTFRVLRAL 236
V+++ + + L P Y+ +N D FVV T +++G ++ LR R+LR
Sbjct: 574 VEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIF 633
Query: 237 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 634 KVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 680
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ +I FI+AV+GMQ+FGK + +
Sbjct: 1301 MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQI 1360
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESM 924
+ NF F + +++FR GE W E M
Sbjct: 1361 NRNN----NFQTFPQAVLLLFRCATGEAWQEIM 1389
Score = 37.5 bits (83), Expect = 0.48
Identities = 15/57 (26%), Positives = 37/57 (64%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L+++++ + + + L ++ ++ +I I+A++G++LF
Sbjct: 203 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 259
>AF067227-1|AAD03587.1| 1912|Homo sapiens voltage-gated L-type calcium
channel alpha-1 subunit protein.
Length = 1912
Score = 313 bits (769), Expect = 4e-84
Identities = 207/670 (30%), Positives = 352/670 (52%), Gaps = 43/670 (6%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR LI + F ++ I+LSS++LA ED H IL Y D FT IF +E
Sbjct: 795 LRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHS-FRNHILGYFDYAFTSIFTVE 853
Query: 1267 MLIKWLALG---FQKYFTNAWC-WLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G + F +W LD ++V VSLI+F + I K +R LR LR
Sbjct: 854 ILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH---SSAISVVKILRVLRVLR 910
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD-MNH 1381
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK++ C D H
Sbjct: 911 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKH 970
Query: 1382 TTL----SHEIIPDKNAC--TLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T S + PD + + W NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 971 TPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1030
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
ID+ PI + + ++ +N+F+G +I F Q ++ + E+
Sbjct: 1031 IDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDK 1090
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+ Q Y A+K +PL+ P+ Q V+ V F+ ++ L I LN + + +
Sbjct: 1091 NQRQCVEY-ALK----AQPLRRY-IPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAM 1144
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSL 1614
HY+Q+ F+ +D LNM+F +F+ E +LKI A + HYF + WN FD ++V+ SI+ +
Sbjct: 1145 QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDI 1204
Query: 1615 VLSDIIEKYFV-------SPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFN 1667
++++ + S + R+ +V R+++L+ +GIRTLL+ S AL
Sbjct: 1205 AVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPY 1264
Query: 1668 ICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
+ LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T W ++
Sbjct: 1265 VALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM 1324
Query: 1726 DGIINEEECDLPDNERGSPG---NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQ 1782
+ CD P+++ G PG CGS I Y +S+ ++ ++IN+++AVI++N+
Sbjct: 1325 LASLPGNRCD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDY 1381
Query: 1783 ATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY-- 1838
T D L D + IW +DP I++ + L ++PPL K P++
Sbjct: 1382 LTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVAC 1440
Query: 1839 -KIISMDIPI 1847
++++M++P+
Sbjct: 1441 KRLVAMNMPL 1450
Score = 112 bits (269), Expect = 1e-23
Identities = 79/301 (26%), Positives = 150/301 (49%), Gaps = 61/301 (20%)
Query: 143 FSLFIITTILVNCILM--IMP--------TTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
F + I+ TI NC+ + +P +E E +F I+T E+ +K++A G +L
Sbjct: 29 FDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVL 88
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLG-----------------NLAALRTFRVLRA 235
P Y+R+ WN LDF+++ + ++ ++ G ++ ALR FRVLR
Sbjct: 89 HPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRP 148
Query: 236 LKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPE 295
L+ V+ VP L ++ ++++++ L + +L +F + ++A++GL++++G + + C +
Sbjct: 149 LRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFL--- 205
Query: 296 DGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYT 355
GS D E D C +S C +G P PN G T
Sbjct: 206 -GS-----DMEAEE-------------DPSPCASSGSGRACTLNQTECRGRWPGPNGGIT 246
Query: 356 SFDTFGWAFLSAFRLMTQDYWENL---------YQL---FFVVIIFLGSFYLVNLILAIV 403
+FD F +A L+ F+ +T + W ++ Y+L +FV ++ GSF+++NL+L ++
Sbjct: 247 NFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVL 306
Query: 404 A 404
+
Sbjct: 307 S 307
Score = 87.4 bits (207), Expect = 5e-16
Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 12/194 (6%)
Query: 1542 IMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-N 1600
++L + LN LT+ +H+ Q + + +Y N + + +F+ E LLK++ L +V + N
Sbjct: 470 VLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFN 529
Query: 1601 LFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1660
FD VV IL L +E + P + V+R ++ R+ ++ + + L+ +L
Sbjct: 530 RFDCFVVCGGILETTL---VEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLN 586
Query: 1661 SLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILLFQMS 1716
S+ ++ ++ LLLFL + IF++ GM F K D + F TF Q+++ +FQ+
Sbjct: 587 SMKSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDQTHTKRSTFDTFPQALLTVFQIL 643
Query: 1717 TSAGWDGVL-DGII 1729
T W+ V+ DGI+
Sbjct: 644 TGEDWNVVMYDGIM 657
Score = 86.2 bits (204), Expect = 1e-15
Identities = 74/266 (27%), Positives = 124/266 (46%), Gaps = 40/266 (15%)
Query: 1252 LYYMDRIFTVIFFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV------- 1300
L ++ +F VIF +E ++K +A G Y N W LDFIIV+V L + +
Sbjct: 62 LEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR 121
Query: 1301 ---AALCGA--GGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1355
A G GG K +R R LRPLR +S + + +V+N++++A+ + ++ L+ L
Sbjct: 122 PGDAPHTGGKPGGFDV-KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVL 180
Query: 1356 IFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK-------NACTLENY----TW-- 1402
+I+AI+G++LF G+ K + + E P ACTL W
Sbjct: 181 FVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPG 240
Query: 1403 -ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
NFD+ A L +FQ T +GW ++ D+ +G + ++Y
Sbjct: 241 PNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLV 291
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F+++++KA
Sbjct: 292 IFGSFFVLNLVLGVLSGEFSKEREKA 317
Score = 73.7 bits (173), Expect = 6e-12
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 30/273 (10%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR + + +++ AV+ ++ L++L +A E H L I Y +++ +F +E
Sbjct: 453 LRARCRRAVKSNACYWAVLLLVFLNTLTIASE--HHGQPVWLTQIQEYANKVLLCLFTVE 510
Query: 1267 MLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRA 1326
ML+K LG Y ++ + D +V ++ GA +R +R LR +
Sbjct: 511 MLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKV 570
Query: 1327 MSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSH 1386
+ +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+ D HT S
Sbjct: 571 TRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDQTHTKRS- 627
Query: 1387 EIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPI 1446
FD +A L +FQ+ T + W +M D I + P
Sbjct: 628 ---------------------TFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFP- 665
Query: 1447 RETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDN 1479
+ + +Y LN+F+ + +DN
Sbjct: 666 ---GMLVCIYFIILFICGNYILLNVFLAIAVDN 695
Score = 71.7 bits (168), Expect = 2e-11
Identities = 44/176 (25%), Positives = 90/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
+A + L NP+R+ ++ H +F+ I+ I+++ + + S +
Sbjct: 784 SAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFD 843
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
FT I+T E +K+ G L ++ R +N LD +V++++ ++ GI ++ L
Sbjct: 844 YAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKIL 903
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 904 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 959
Score = 70.5 bits (165), Expect = 6e-11
Identities = 54/179 (30%), Positives = 91/179 (50%), Gaps = 16/179 (8%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSE 1582
Q + IV K FD++I+L I N + + + S T + L+ + +F+VIF+ E
Sbjct: 17 QTLGASIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVE 76
Query: 1583 CLLKIFA--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL-------- 1629
+LKI A L H Y WNL DF++V+ + S++L + +P
Sbjct: 77 TVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFD 136
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ +R +V R LRLV G + +L ++ +L L +I LL+ V+ I+AI G+ F+
Sbjct: 137 VKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 195
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/101 (31%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + +M ++ +L +L + I IF+++GMQLFG +
Sbjct: 559 LRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF- 617
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
F R F F + + VF++L GE W M+D
Sbjct: 618 ----NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYD 654
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 27/168 (16%)
Query: 143 FSLFIITTILVNCILMIMP----TTP---TVESTEVIFTGIYTFESAVKVMARGFILQPF 195
F + IL+N + + M T P ++ ++FTG++T E +K++A +P
Sbjct: 1127 FEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FKPK 1182
Query: 196 TYLRDAWNWLDFVV-------IALAYVTMGIDLG---------NLAALRTFRVLRALKTV 239
Y DAWN D ++ IA+ V G LG ++ R FRV+R +K +
Sbjct: 1183 HYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLL 1242
Query: 240 AIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQ 287
+ G++T++ I+S + L V +L ++A++G+Q++ V Q
Sbjct: 1243 SKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQ 1290
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/107 (25%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 183 VKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLG-----NLAALRTFRVLRAL 236
V+++ + + L P Y+ +N D FVV T +++G ++ LR R+LR
Sbjct: 509 VEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIF 568
Query: 237 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
K L +V +++ S+K++ +++L + +F+L+G+Q++ G
Sbjct: 569 KVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 615
Score = 41.5 bits (93), Expect = 0.029
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ +I FI+AV+GMQ+FGK + +
Sbjct: 1236 MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQI 1295
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESM 924
+ NF F + +++FR GE W E M
Sbjct: 1296 NRNN----NFQTFPQAVLLLFRCATGEAWQEIM 1324
Score = 37.5 bits (83), Expect = 0.48
Identities = 15/57 (26%), Positives = 37/57 (64%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L+++++ + + + L ++ ++ +I I+A++G++LF
Sbjct: 138 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 194
>Z74996-1|CAA99284.1| 2157|Homo sapiens voltage-dependent L-type
calcium channel alpha 1C protein.
Length = 2157
Score = 313 bits (768), Expect = 5e-84
Identities = 204/681 (29%), Positives = 364/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34822-1|CAA84353.1| 2173|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2173
Score = 313 bits (768), Expect = 5e-84
Identities = 204/681 (29%), Positives = 364/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34817-1|CAA84348.1| 2139|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2139
Score = 313 bits (768), Expect = 5e-84
Identities = 204/681 (29%), Positives = 364/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>Z34815-1|CAA84346.1| 2138|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2138
Score = 313 bits (768), Expect = 5e-84
Identities = 204/681 (29%), Positives = 364/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>AJ224873-1|CAA12174.1| 2138|Homo sapiens voltage-dependent L-type
calcium channel alpha-1Ced channel hHCN2 protein.
Length = 2138
Score = 313 bits (768), Expect = 5e-84
Identities = 204/681 (29%), Positives = 364/681 (53%), Gaps = 46/681 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPA 1664
++++ E SP++ + R+ +V R+++L+ +GIRTLL+ S A
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1665 LFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWD 1722
L + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++LLF+ +T W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1723 GVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILEN 1779
++ + ++C P N CGS + + Y +S+ ++ ++IN+++AVI++N
Sbjct: 1420 DIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
Query: 1780 YSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNK 1837
+ T D L D + IW +DP+ I++ + L ++PPL K P++
Sbjct: 1479 FDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHR 1537
Query: 1838 Y---KIISMDIPI-CRGDMMF 1854
+++SM++P+ G +MF
Sbjct: 1538 VACKRLVSMNMPLNSDGTVMF 1558
Score = 134 bits (323), Expect = 4e-30
Identities = 95/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENL---------YQL-- 382
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W ++ Y+L
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW 382
Query: 383 -FFVVIIFLGSFYLVNLILAIVA 404
+FV ++ GSF+++NL+L +++
Sbjct: 383 VYFVSLVIFGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 95.9 bits (228), Expect = 1e-18
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ +G + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWMQDA--MGYE-------LPWVYFVSLVIFGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1329
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1330 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1382
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1393
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1394 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1426
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>M76558-1|AAA58402.1| 2161|Homo sapiens calcium channel alpha-1D
subunit protein.
Length = 2161
Score = 312 bits (765), Expect = 1e-83
Identities = 213/685 (31%), Positives = 357/685 (52%), Gaps = 50/685 (7%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ KLI + F ++ I+LSS ALA ED H IL Y D FT IF +E
Sbjct: 875 IRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHS-FRNTILGYFDYAFTAIFTVE 933
Query: 1267 MLIKWLALG--FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+L+K G K + N + LD ++V VSL++F + I K +R LR LR
Sbjct: 934 ILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQ---SSAISVVKILRVLRVLR 990
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD---M 1379
PLRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK+++C D
Sbjct: 991 PLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKS 1050
Query: 1380 NHTTLSHEII----PDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
N I D ++ + W+NS NFD+V A + LF V+TF+GW ++ A
Sbjct: 1051 NPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKA 1110
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + + ++ +N+F+G +I F EQ +K + E+
Sbjct: 1111 IDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDK 1170
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ + Q + +V F+ ++ + I LN L +
Sbjct: 1171 NQRQCVEY-ALK----ARPLRRYIPKNPY--QYKFWYVVNSSPFEYMMFVLIMLNTLCLA 1223
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILS 1613
+ HY+QS+ F+ +D LNM+F +F+ E +LK+ A + YF + WN FD ++V+ SI+
Sbjct: 1224 MQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIID 1283
Query: 1614 LVLS--DIIEKYFVS-PTL------------LRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1658
+ LS D E V PT + R+ +V R+++L+ +GIRTLL+
Sbjct: 1284 VALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTF 1343
Query: 1659 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMS 1716
AL + LL+ ++ FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +
Sbjct: 1344 IKFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCA 1403
Query: 1717 TSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAV 1775
T W ++ + + CD D G CGS I Y +S+ ++ ++IN+++AV
Sbjct: 1404 TGEAWQEIMLACLPGKLCDPESDYNPGEEHTCGS-NFAIVYFISFYMLCAFLIINLFVAV 1462
Query: 1776 ILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK- 1834
I++N+ T D L D + IW +DP+ I++ + L ++PPL K
Sbjct: 1463 IMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKL 1521
Query: 1835 -PNKY---KIISMDIPI-CRGDMMF 1854
P++ ++++M++P+ G +MF
Sbjct: 1522 CPHRVACKRLVAMNMPLNSDGTVMF 1546
Score = 124 bits (299), Expect = 3e-27
Identities = 96/325 (29%), Positives = 161/325 (49%), Gaps = 63/325 (19%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL+ L NPIRR I I+ F +FI+ I NC+ + + T +E
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIA-------LAYVTMGIDLG 222
E F I+T E+ +K++A G +L P Y+R+ WN LDFV++ L +T + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 223 N----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
N + ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL++++G + + C F D ++ E D C S
Sbjct: 285 YAIIGLELFIGKMHKTC---FFAD---SDIVAEE----------------DPAPCAFSGN 322
Query: 333 AGQCEP-GYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQD------YWEN------L 379
QC G C G+ PN G T+FD F +A L+ F+ +T + YW N L
Sbjct: 323 GRQCTANGTECRSGW-VGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFEL 381
Query: 380 YQLFFVVIIFLGSFYLVNLILAIVA 404
++FV ++ GSF+++NL+L +++
Sbjct: 382 PWVYFVSLVIFGSFFVLNLVLGVLS 406
Score = 98.7 bits (235), Expect = 2e-19
Identities = 67/252 (26%), Positives = 128/252 (50%), Gaps = 24/252 (9%)
Query: 1538 FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFV 1596
F ++++ + LN LT++ +HY Q + + + D N + + +F+ E L+K+++L YFV
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFV 584
Query: 1597 EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF 1656
+N FD VV I +L +E +SP + V R ++ R+ ++ + + L+
Sbjct: 585 SLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSLCNLVA 641
Query: 1657 ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQSMILL 1712
+L S+ + ++ LLLFL + IF++ GM F K D+ F F Q+++ +
Sbjct: 642 SLLNSMKSSASLLLLLFLFIIIFSLLGMQLF---GGKFNFDETQTKRSTFDNFPQALLTV 698
Query: 1713 FQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINM 1771
FQ+ T W+ V+ DGI+ G P + G I Y + + I++N+
Sbjct: 699 FQILTGEDWNAVMYDGIM----------AYGGPSSSG--MIVCIYFIILFICGNYILLNV 746
Query: 1772 YIAVILENYSQA 1783
++A+ ++N + A
Sbjct: 747 FLAIAVDNLADA 758
Score = 88.6 bits (210), Expect = 2e-16
Identities = 82/314 (26%), Positives = 139/314 (44%), Gaps = 45/314 (14%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E F+ ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTV 174
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALC-----------GAGGIQ 1310
F++++ L L Y N W LDF+IV+V L + + G G
Sbjct: 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGF 234
Query: 1311 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF
Sbjct: 235 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294
Query: 1371 GKYFK-CVDMNHTTLSHE------IIPDKNACTLENYT----W---ENSPMNFDHVGKAY 1416
GK K C + ++ E + CT W NFD+ A
Sbjct: 295 GKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAM 354
Query: 1417 LCLFQVATFKGWIQI---MNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFI 1473
L +FQ T +GW + MNDA+ ++Y LNL +
Sbjct: 355 LTVFQCITMEGWTDVLYWMNDAMGFE------------LPWVYFVSLVIFGSFFVLNLVL 402
Query: 1474 GVIIDNFNEQKKKA 1487
GV+ F+++++KA
Sbjct: 403 GVLSGEFSKEREKA 416
Score = 72.5 bits (170), Expect = 1e-11
Identities = 66/305 (21%), Positives = 133/305 (43%), Gaps = 37/305 (12%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIF 1259
W+ W R + +++ F VI ++ L++L ++ E + P L I +++
Sbjct: 505 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW--LTQIQDIANKVL 562
Query: 1260 TVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAA---LCGAGGIQAFKTMR 1316
+F EML+K +LG Q YF + + D +V + + + GI F+ +R
Sbjct: 563 LALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVR 622
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
LR + R + + + V +L+ ++ S ++LL+ +F +IF+++G+QLF GK+
Sbjct: 623 LLRIFKVTRHWTSLCNL---VASLLNSMKSSASLLLLLFLFIIIFSLLGMQLFGGKF--- 676
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ + T + FD+ +A L +FQ+ T + W +M D I
Sbjct: 677 -NFDET--------------------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGI 715
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ + + + +Y LN+F+ + +DN + + E
Sbjct: 716 ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 771
Query: 1497 EDQKK 1501
+++KK
Sbjct: 772 KERKK 776
Score = 70.9 bits (166), Expect = 4e-11
Identities = 45/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT---TPTVEST-----E 170
+A +IL NPIR ++ H +F+ I+ I+++ + + + +T +
Sbjct: 864 SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFD 923
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTF 230
FT I+T E +K+ G L + R+ +N LD +V+ ++ V+ GI ++ ++
Sbjct: 924 YAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKIL 983
Query: 231 RVLRALKTVAIV---PGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
RVLR L+ + + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 984 RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1039
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/173 (28%), Positives = 87/173 (50%), Gaps = 16/173 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K FD+ I+L I N + + + S + + L+ + F++IF+ E LKI
Sbjct: 122 IVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKII 181
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL--------LRVVRV 1635
A L H Y WNL DFV+V+ + S++L + ++ ++ +R
Sbjct: 182 AYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRA 241
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+V R LRLV G ++ +L ++ ++ L +I LL+ V+ I+AI G+ F+
Sbjct: 242 FRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFI 294
Score = 58.0 bits (134), Expect = 3e-07
Identities = 31/95 (32%), Positives = 54/95 (56%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ + W +L L++ + +M + +L +L + I IF+++GMQLFG + F
Sbjct: 624 LRIFKVTRHWTSLCNLVASLLNSMKSSASLLLLLFLFIIIFSLLGMQLFGGKF-----NF 678
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
+ R F +F + + VF++L GE W M+D
Sbjct: 679 DETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYD 713
Score = 44.8 bits (101), Expect = 0.003
Identities = 40/187 (21%), Positives = 83/187 (44%), Gaps = 35/187 (18%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYT 178
P NP + Y++ F + I++N + + M ++ ++FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID----------------LG 222
E +KV+A +P Y DAWN D +++ + + + + G
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305
Query: 223 N--------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFA 274
N + R FRV+R +K ++ G++T++ I+ + L V +L ++A
Sbjct: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIYA 1365
Query: 275 LMGLQIY 281
++G+Q++
Sbjct: 1366 VIGMQMF 1372
Score = 41.9 bits (94), Expect = 0.022
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ + AL + ++ ++ FI+AV+GMQ+FGK + ++
Sbjct: 1324 MRLVKLLSRGEGIRTLLWTFIKFFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQI 1383
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W E M C+
Sbjct: 1384 NRNN----NFQTFPQAVLLLFRCATGEAWQEIMLACL 1416
Score = 38.3 bits (85), Expect = 0.27
Identities = 31/118 (26%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD-FVVIALAYVTMGIDLGNLAAL--- 227
+ ++T E VK+ + G LQ Y +N D FVV T+ ++L ++ L
Sbjct: 561 VLLALFTCEMLVKMYSLG--LQ--AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGIS 616
Query: 228 --RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R R+LR K L +V +++ S+K+ +++L + +F+L+G+Q++ G
Sbjct: 617 VFRCVRLLRIFKVTRHWTSLCNLVASLLNSMKSSASLLLLLFLFIIIFSLLGMQLFGG 674
Score = 37.5 bits (83), Expect = 0.48
Identities = 16/57 (28%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF
Sbjct: 237 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
>DQ494471-1|ABF69922.1| 2291|Homo sapiens T calcium channel alpha 1G
subunit variant 249 protein.
Length = 2291
Score = 309 bits (758), Expect = 8e-83
Identities = 186/619 (30%), Positives = 332/619 (53%), Gaps = 51/619 (8%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKM---------GSKKPLKAIPRPRWRP--------QAIVFEIVTDKKF 1538
+KK + K+M S A + +P + +V + T
Sbjct: 1561 RRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYL 1620
Query: 1539 DMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVE 1597
D+ I IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F +
Sbjct: 1621 DLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQD 1680
Query: 1598 PWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLL 1655
WN D +V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL
Sbjct: 1681 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALL 1740
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMI 1710
+ +LP + N+ LL L+ FIFA G+ F ++ D+ GL F+ F + +
Sbjct: 1741 DTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFL 1800
Query: 1711 LLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
LF++ST W+G++ + +CD C + I Y +S+++ + +++N
Sbjct: 1801 TLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVN 1851
Query: 1771 MYIAVILENYSQATEDVQE 1789
+ IAV++++ ++ ++ +E
Sbjct: 1852 VVIAVLMKHLEESNKEAKE 1870
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1599 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1656
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1657 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1716
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1717 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1774
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1775 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1816
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1817 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1874
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1725 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1782
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1783 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1819
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1607 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1656
>BC133671-1|AAI33672.1| 1873|Homo sapiens CACNA1S protein protein.
Length = 1873
Score = 308 bits (757), Expect = 1e-82
Identities = 209/682 (30%), Positives = 360/682 (52%), Gaps = 55/682 (8%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ VV + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF +PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLL----------------RV----VRVAKVGRVLRLVKGAKGIRT 1653
++LS+ I+ + S L R+ R+ +V R+++L+ A+G+RT
Sbjct: 1197 VILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255
Query: 1654 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMIL 1711
LL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++L
Sbjct: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLL 1315
Query: 1712 LFQMSTSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
LF+ +T W +L + CD D G CG+ Y +S+ ++ +VIN
Sbjct: 1316 LFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVIN 1374
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
+++AVI++N+ T D L D + IW +DP+ I++ + L ++PPL
Sbjct: 1375 LFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
Query: 1831 QIHK--PNKY---KIISMDIPI 1847
K P++ +++ M++P+
Sbjct: 1434 GFGKFCPHRVACKRLVGMNMPL 1455
Score = 122 bits (294), Expect = 1e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C G+ P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSECRGGW-PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 100 bits (239), Expect = 6e-20
Identities = 69/256 (26%), Positives = 133/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IFA+ GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ G P G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM----------AYGGPSYPG--MLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 92.7 bits (220), Expect = 1e-17
Identities = 87/320 (27%), Positives = 145/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYT----W---ENSPMNFD 1410
LF GK YF D+ T + E P CT+ W + +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 87.4 bits (207), Expect = 5e-16
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IFA++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YGGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.9 bits (156), Expect = 7e-10
Identities = 35/95 (36%), Positives = 59/95 (62%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IFA++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 57.2 bits (132), Expect = 6e-07
Identities = 43/173 (24%), Positives = 92/173 (53%), Gaps = 12/173 (6%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIF 1579
P + + + IV F I+LFI L+ + + ++++ + +L + ++ F +F
Sbjct: 784 PTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVF 843
Query: 1580 SSECLLKI-----FALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ F + + +N+ D +VV S++S+ L E +S +++++R
Sbjct: 844 TVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGL----ESSAIS--VVKILR 897
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
V +V R LR + AKG++ ++ + +++ + NI L+ L+ F+FA G+ F
Sbjct: 898 VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLF 950
Score = 44.0 bits (99), Expect = 0.006
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ S++++ +++L + +FAL+G+Q++ G
Sbjct: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
Query: 284 VLTQKCVKV-------FPED--GSWGNLTDENWERFCQNETNWYGEGGDYP 325
+ +V FP+ + LT E+W N YG G YP
Sbjct: 584 RYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-GPSYP 633
Score = 43.6 bits (98), Expect = 0.007
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 39/191 (20%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P NP + YI+ F + I++N I + M E V FT I+T
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFT 1162
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------------------TMGID 220
E +K+MA + Y D WN DF+++ + + +G
Sbjct: 1163 LEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query: 221 LGNL----------AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSL 270
GN+ A R FRV+R +K ++ G++T++ I+S + L V +L +
Sbjct: 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query: 271 SVFALMGLQIY 281
++A++G+Q++
Sbjct: 1279 FIYAVIGMQMF 1289
Score = 40.7 bits (91), Expect = 0.052
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 10/116 (8%)
Query: 818 NMDKDMDKALKSGNY-----LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 872
N+D D + S + +R+ KL + L+ ++ AL + ++ ++ FI
Sbjct: 1221 NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFI 1280
Query: 873 FAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDC 927
+AV+GMQ+FGK + VD NF F + +++FR GE W E + C
Sbjct: 1281 YAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>AL358473-2|CAI12386.1| 1873|Homo sapiens calcium channel,
voltage-dependent, L type, alphafluid) protein.
Length = 1873
Score = 308 bits (757), Expect = 1e-82
Identities = 209/682 (30%), Positives = 360/682 (52%), Gaps = 55/682 (8%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ VV + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF +PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLL----------------RV----VRVAKVGRVLRLVKGAKGIRT 1653
++LS+ I+ + S L R+ R+ +V R+++L+ A+G+RT
Sbjct: 1197 VILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255
Query: 1654 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMIL 1711
LL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++L
Sbjct: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLL 1315
Query: 1712 LFQMSTSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
LF+ +T W +L + CD D G CG+ Y +S+ ++ +VIN
Sbjct: 1316 LFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVIN 1374
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
+++AVI++N+ T D L D + IW +DP+ I++ + L ++PPL
Sbjct: 1375 LFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
Query: 1831 QIHK--PNKY---KIISMDIPI 1847
K P++ +++ M++P+
Sbjct: 1434 GFGKFCPHRVACKRLVGMNMPL 1455
Score = 122 bits (294), Expect = 1e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C G+ P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSECRGGW-PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 100 bits (239), Expect = 6e-20
Identities = 69/256 (26%), Positives = 133/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IFA+ GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ G P G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM----------AYGGPSYPG--MLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 92.7 bits (220), Expect = 1e-17
Identities = 87/320 (27%), Positives = 145/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYT----W---ENSPMNFD 1410
LF GK YF D+ T + E P CT+ W + +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 87.4 bits (207), Expect = 5e-16
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IFA++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YGGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.9 bits (156), Expect = 7e-10
Identities = 35/95 (36%), Positives = 59/95 (62%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IFA++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 57.2 bits (132), Expect = 6e-07
Identities = 43/173 (24%), Positives = 92/173 (53%), Gaps = 12/173 (6%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIF 1579
P + + + IV F I+LFI L+ + + ++++ + +L + ++ F +F
Sbjct: 784 PTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVF 843
Query: 1580 SSECLLKI-----FALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ F + + +N+ D +VV S++S+ L E +S +++++R
Sbjct: 844 TVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGL----ESSAIS--VVKILR 897
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
V +V R LR + AKG++ ++ + +++ + NI L+ L+ F+FA G+ F
Sbjct: 898 VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLF 950
Score = 44.0 bits (99), Expect = 0.006
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ S++++ +++L + +FAL+G+Q++ G
Sbjct: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
Query: 284 VLTQKCVKV-------FPED--GSWGNLTDENWERFCQNETNWYGEGGDYP 325
+ +V FP+ + LT E+W N YG G YP
Sbjct: 584 RYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-GPSYP 633
Score = 43.6 bits (98), Expect = 0.007
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 39/191 (20%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P NP + YI+ F + I++N I + M E V FT I+T
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFT 1162
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------------------TMGID 220
E +K+MA + Y D WN DF+++ + + +G
Sbjct: 1163 LEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query: 221 LGNL----------AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSL 270
GN+ A R FRV+R +K ++ G++T++ I+S + L V +L +
Sbjct: 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query: 271 SVFALMGLQIY 281
++A++G+Q++
Sbjct: 1279 FIYAVIGMQMF 1289
Score = 40.7 bits (91), Expect = 0.052
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 10/116 (8%)
Query: 818 NMDKDMDKALKSGNY-----LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 872
N+D D + S + +R+ KL + L+ ++ AL + ++ ++ FI
Sbjct: 1221 NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFI 1280
Query: 873 FAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDC 927
+AV+GMQ+FGK + VD NF F + +++FR GE W E + C
Sbjct: 1281 YAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>AL139159-1|CAI23207.1| 1873|Homo sapiens calcium channel,
voltage-dependent, L type, alphase 5 (class III), chi
polypept protein.
Length = 1873
Score = 308 bits (757), Expect = 1e-82
Identities = 209/682 (30%), Positives = 360/682 (52%), Gaps = 55/682 (8%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ VV + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF +PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLL----------------RV----VRVAKVGRVLRLVKGAKGIRT 1653
++LS+ I+ + S L R+ R+ +V R+++L+ A+G+RT
Sbjct: 1197 VILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255
Query: 1654 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMIL 1711
LL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++L
Sbjct: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLL 1315
Query: 1712 LFQMSTSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
LF+ +T W +L + CD D G CG+ Y +S+ ++ +VIN
Sbjct: 1316 LFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVIN 1374
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
+++AVI++N+ T D L D + IW +DP+ I++ + L ++PPL
Sbjct: 1375 LFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
Query: 1831 QIHK--PNKY---KIISMDIPI 1847
K P++ +++ M++P+
Sbjct: 1434 GFGKFCPHRVACKRLVGMNMPL 1455
Score = 122 bits (294), Expect = 1e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C G+ P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSECRGGW-PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 100 bits (239), Expect = 6e-20
Identities = 69/256 (26%), Positives = 133/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IFA+ GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ G P G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM----------AYGGPSYPG--MLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 92.7 bits (220), Expect = 1e-17
Identities = 87/320 (27%), Positives = 145/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYT----W---ENSPMNFD 1410
LF GK YF D+ T + E P CT+ W + +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 87.4 bits (207), Expect = 5e-16
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IFA++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YGGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 73.3 bits (172), Expect = 8e-12
Identities = 44/176 (25%), Positives = 92/176 (52%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK +V + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.9 bits (156), Expect = 7e-10
Identities = 35/95 (36%), Positives = 59/95 (62%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IFA++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 57.2 bits (132), Expect = 6e-07
Identities = 43/173 (24%), Positives = 92/173 (53%), Gaps = 12/173 (6%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIF 1579
P + + + IV F I+LFI L+ + + ++++ + +L + ++ F +F
Sbjct: 784 PTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVF 843
Query: 1580 SSECLLKI-----FALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ F + + +N+ D +VV S++S+ L E +S +++++R
Sbjct: 844 TVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGL----ESSAIS--VVKILR 897
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
V +V R LR + AKG++ ++ + +++ + NI L+ L+ F+FA G+ F
Sbjct: 898 VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLF 950
Score = 44.0 bits (99), Expect = 0.006
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ S++++ +++L + +FAL+G+Q++ G
Sbjct: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
Query: 284 VLTQKCVKV-------FPED--GSWGNLTDENWERFCQNETNWYGEGGDYP 325
+ +V FP+ + LT E+W N YG G YP
Sbjct: 584 RYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-GPSYP 633
Score = 43.6 bits (98), Expect = 0.007
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 39/191 (20%)
Query: 126 PFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTE-------VIFTGIYT 178
P NP + YI+ F + I++N I + M E V FT I+T
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFT 1162
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYV------------------TMGID 220
E +K+MA + Y D WN DF+++ + + +G
Sbjct: 1163 LEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query: 221 LGNL----------AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSL 270
GN+ A R FRV+R +K ++ G++T++ I+S + L V +L +
Sbjct: 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query: 271 SVFALMGLQIY 281
++A++G+Q++
Sbjct: 1279 FIYAVIGMQMF 1289
Score = 40.7 bits (91), Expect = 0.052
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 10/116 (8%)
Query: 818 NMDKDMDKALKSGNY-----LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 872
N+D D + S + +R+ KL + L+ ++ AL + ++ ++ FI
Sbjct: 1221 NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFI 1280
Query: 873 FAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDC 927
+AV+GMQ+FGK + VD NF F + +++FR GE W E + C
Sbjct: 1281 YAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>AY682085-1|AAT85834.1| 539|Homo sapiens voltage-gated sodium
channel Nav1.7 protein.
Length = 539
Score = 307 bits (754), Expect = 2e-82
Identities = 161/275 (58%), Positives = 200/275 (72%), Gaps = 23/275 (8%)
Query: 151 ILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVV 209
IL NCI M M P ++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDFVV
Sbjct: 1 ILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 60
Query: 210 IALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFS 269
I AY+T ++LGN++ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F
Sbjct: 61 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFC 120
Query: 270 LSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETN-----WYGEG-GD 323
LSVFAL+GLQ+ MG L KC + E+ N T E+ ++E + +Y EG D
Sbjct: 121 LSVFALIGLQLSMGNLKHKCFRNSLEN----NETLESIMNTLESEEDFRKYFYYLEGPKD 176
Query: 324 YPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ-- 381
LCG S+ +GQC GY C++ G NP+YGYTSFDTF WAFL+ FRLMTQDYWENLYQ
Sbjct: 177 ALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQT 235
Query: 382 ---------LFFVVIIFLGSFYLVNLILAIVAMSY 407
+FFVV+IFLGSFYL+NLILA+VAM+Y
Sbjct: 236 LRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 270
Score = 69.7 bits (163), Expect = 1e-10
Identities = 38/123 (30%), Positives = 70/123 (56%), Gaps = 11/123 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K LA GF + + W WLDF++++ + ++ G + A
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSA--- 77
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY- 1373
+RT R LR L+ +S + G++ +V AL+Q++ + +V+++ + +FA++G+QL G
Sbjct: 78 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLSMGNLK 137
Query: 1374 FKC 1376
KC
Sbjct: 138 HKC 140
Score = 51.6 bits (118), Expect = 3e-05
Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 1575 FIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DFVV++F+ L+ FV+
Sbjct: 24 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGN 74
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM- 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ M
Sbjct: 75 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLSMG 134
Query: 1689 HVKDKGGLDDVYNFKTFVQSM 1709
++K K + + N +T M
Sbjct: 135 NLKHKCFRNSLENNETLESIM 155
>DQ494457-1|ABF69908.1| 2259|Homo sapiens T calcium channel alpha 1G
subunit variant 137 protein.
Length = 2259
Score = 307 bits (753), Expect = 3e-82
Identities = 181/597 (30%), Positives = 321/597 (53%), Gaps = 39/597 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1557
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1558 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1617
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1618 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1677
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMF 1677
++PT++R++RV ++ RVL+L+K A G+R LL + N+ LL L+ F
Sbjct: 1678 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVG-------NLGLLFMLLFF 1730
Query: 1678 IFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
IFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1731 IFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--R 1788
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1789 DCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1838
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 85.4 bits (202), Expect = 2e-15
Identities = 74/300 (24%), Positives = 132/300 (44%), Gaps = 36/300 (12%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1574 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1631
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++ N+ L+ ++ + IFA +GV+LF
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLD-------TVGNLGLLFMLLFFIFAALGVELFGD-- 1742
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1743 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1784
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1785 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1842
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 5/98 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+RV ++A+ L + + M + +GNL + ++ FIFA +G++LFG D +
Sbjct: 1693 MRVLRIARVLKLLKMAVG-MRALLDTVGNLGLLFMLLFFIFAALGVELFGDLECD--ETH 1749
Query: 893 PDGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
P L R F +F +F+ +FRV G+ W M D +
Sbjct: 1750 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1787
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1582 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631
>L33798-1|AAA51902.1| 1873|Homo sapiens dihydropyridine-sensitive
L-type calcium channel alpha-1 subunit protein.
Length = 1873
Score = 306 bits (751), Expect = 6e-82
Identities = 208/682 (30%), Positives = 358/682 (52%), Gaps = 55/682 (8%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ V + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLKHVARCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1084 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1136
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF PWN+FDF++V+ SI+
Sbjct: 1137 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIID 1196
Query: 1614 LVLSDIIEKYFVSPTLL----------------RV----VRVAKVGRVLRLVKGAKGIRT 1653
++LS+ I+ + S L R+ R+ +V R+++L+ A+G+RT
Sbjct: 1197 VILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255
Query: 1654 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMIL 1711
LL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++L
Sbjct: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLL 1315
Query: 1712 LFQMSTSAGWDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIVIN 1770
LF+ +T W +L + CD D G CG+ Y +S+ ++ +VIN
Sbjct: 1316 LFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVIN 1374
Query: 1771 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPL 1830
+++AVI++N+ T D L D + IW +DP+ I++ + L ++PPL
Sbjct: 1375 LFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
Query: 1831 QIHK--PNKY---KIISMDIPI 1847
K P++ +++ M++P+
Sbjct: 1434 GFGKFCPHRVACKRLVGMNMPL 1455
Score = 121 bits (292), Expect = 2e-26
Identities = 92/324 (28%), Positives = 159/324 (49%), Gaps = 58/324 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VEST 169
AL+ L NP+R+ I I+ F I+ TI NC+ + MP +E
Sbjct: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN------ 223
E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
Query: 224 -----------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSV 272
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F + +
Sbjct: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
Query: 273 FALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSG 332
+A++GL+++ G + + C + G+ T EN E P SG
Sbjct: 210 YAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCARTGSG 251
Query: 333 AGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY----------- 380
G C +G P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 252 RRCTINGSEC-RGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP 310
Query: 381 QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 311 WIYFVTLILLGSFFILNLVLGVLS 334
Score = 99.5 bits (237), Expect = 1e-19
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPHWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IF + GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ S G + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIM------------ASSGPSYPGMLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 91.1 bits (216), Expect = 4e-17
Identities = 87/320 (27%), Positives = 144/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYTWENS---P----MNFD 1410
LF GK YF D+ T + E P CT+ P +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 90.6 bits (215), Expect = 5e-17
Identities = 75/303 (24%), Positives = 138/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPH-RPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + PH LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPHWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IF ++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 SSGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 71.7 bits (168), Expect = 2e-11
Identities = 43/176 (24%), Positives = 91/176 (51%), Gaps = 11/176 (6%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA---L 227
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ L
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 228 RTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
R RVLR L+ + GLK + + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 67.7 bits (158), Expect = 4e-10
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 1506 MKKMGSKKPLKAI-PRPRWRPQAIVFE---------IVTDKKFDMIIMLFIGLNMLTMTL 1555
++K KKP+ I PRP + E IV K F+ II+L I N + + +
Sbjct: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
Query: 1556 D---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLFDFVVV 1607
+ + + L+ L F+++FS E +KI A +H Y WN+ DF +V
Sbjct: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
Query: 1608 MFSILSLVLSDI-IEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLLFALA 1659
+ +++L + + + +P ++ +R +V R LRLV G ++ +L ++
Sbjct: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
Query: 1660 MSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ LF+I LL+ ++ I+AI G+ F
Sbjct: 191 KAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.5 bits (155), Expect = 9e-10
Identities = 36/112 (32%), Positives = 63/112 (56%), Gaps = 6/112 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IF ++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
D ++ R NF +F + + VF+VL GE W M++ ++ P L +
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMASSGPSYPGMLVCI 639
Score = 56.4 bits (130), Expect = 1e-06
Identities = 43/173 (24%), Positives = 91/173 (52%), Gaps = 12/173 (6%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIF 1579
P + + + IV F I+LFI L+ + + ++++ + +L + ++ F +F
Sbjct: 784 PTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVF 843
Query: 1580 SSECLLKI-----FALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVR 1634
+ E +LK+ F + + +N+ D +VV S++S+ L E +S +++++R
Sbjct: 844 TVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGL----ESSAIS--VVKILR 897
Query: 1635 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
V +V R LR + AKG++ + + +++ + NI L+ L+ F+FA G+ F
Sbjct: 898 VLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIVLVTTLLQFMFACIGVQLF 950
Score = 40.7 bits (91), Expect = 0.052
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 10/116 (8%)
Query: 818 NMDKDMDKALKSGNY-----LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 872
N+D D + S + +R+ KL + L+ ++ AL + ++ ++ FI
Sbjct: 1221 NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFI 1280
Query: 873 FAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDC 927
+AV+GMQ+FGK + VD NF F + +++FR GE W E + C
Sbjct: 1281 YAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>Z34818-1|CAA84349.1| 2158|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2158
Score = 303 bits (745), Expect = 3e-81
Identities = 208/701 (29%), Positives = 366/701 (52%), Gaps = 66/701 (9%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALG---FQKYFT---------------------NAWCWLDFIIVMVSLINFVAAL 1303
+K L F FT N + LD ++V VSLI+F
Sbjct: 949 ALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ- 1007
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+ I K +R LR LRPLRA++R +G++ VV + AI +I N+++V + +FA
Sbjct: 1008 --SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 1364 MGVQLFAGKYFKCVDMNHTTLSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAY 1416
+GVQLF GK + C D + T + I K+ ++ +WENS +FD+V A
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125
Query: 1417 LCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVI 1476
+ LF V+TF+GW +++ +IDS + PI + + ++ +N+F+G +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185
Query: 1477 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDK 1536
I F EQ ++ + E+ + Q Y A+K +PL+ P+ + Q V+ +V
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNST 1239
Query: 1537 KFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYF 1595
F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E +LK+ A + HYF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYF 1299
Query: 1596 VEPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRL 1644
+ WN FD ++V+ SI+ + ++++ E SP++ + R+ +V R+++L
Sbjct: 1300 CDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKL 1359
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNF 1702
+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF
Sbjct: 1360 LSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNF 1419
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLS 1759
+TF Q+++LLF+ +T W ++ + ++C P N CGS + + Y +S
Sbjct: 1420 QTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFIS 1478
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQL 1819
+ ++ ++IN+++AVI++N+ T D L D + IW +DP+ I++ +
Sbjct: 1479 FYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDV 1537
Query: 1820 SDFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 1538 VTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1578
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/138 (28%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
Query: 151 ILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVI 210
I+ I I + + + +FT I+T E +K+ A G L ++ R+ +N LD +V+
Sbjct: 938 IVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 997
Query: 211 ALAYVTMGID---LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTM 267
+++ ++ GI + + LR RVLR L+ + GLK +V V +++ + +++I+T
Sbjct: 998 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057
Query: 268 FSLSVFALMGLQIYMGVL 285
+FA +G+Q++ G L
Sbjct: 1058 LLQFMFACIGVQLFKGKL 1075
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1292
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 1293 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 1349
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 1350 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1402
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1354 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1413
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1414 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1446
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
>AB032946-1|BAA86434.1| 1024|Homo sapiens KIAA1120 protein protein.
Length = 1024
Score = 303 bits (744), Expect = 4e-81
Identities = 169/548 (30%), Positives = 300/548 (54%), Gaps = 31/548 (5%)
Query: 1258 IFTVIFFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ--- 1310
IFT IF EM +K ++LG Q Y ++W LD +V VS+I+ V +L AGG +
Sbjct: 11 IFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILG 70
Query: 1311 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
+ +R LR LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GVQLF
Sbjct: 71 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFK 130
Query: 1371 GKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQ 1430
GK++ C+ ++ I +++ C NY W + NFD++G+A + LF +A+ GW+
Sbjct: 131 GKFYHCLGVDTRN-----ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVN 185
Query: 1431 IMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGS 1490
IM + +D+ V +QP+ N +M LY LN+F+GV+++NF++ ++
Sbjct: 186 IMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 245
Query: 1491 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNM 1550
E + + ++ + P A + ++ + T D+ I I LN+
Sbjct: 246 EARRREEKRLRRLEKKRRKAQRLPYYA---TYCHTRLLIHSMCTSHYLDIFITFIICLNV 302
Query: 1551 LTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI--FALRYHYFVEPWNLFDFVVVM 1608
+TM+L+HY Q + L Y N +F +F E +LK+ F LR +F + WN D +V+
Sbjct: 303 VTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLR-RFFKDRWNQLDLAIVL 361
Query: 1609 FSILSLVLSDI-IEKYF-VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1666
S++ + L +I I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP +
Sbjct: 362 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 421
Query: 1667 NICLLLFLVMFIFAIFGMSFF--MHVKDKG---GLDDVYNFKTFVQSMILLFQMSTSAGW 1721
N+ LL L+ FI+A G+ F + D+ G+ F+ F + + LFQ+ST W
Sbjct: 422 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 481
Query: 1722 DGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYS 1781
+G++ + D +ER + + Y +S+++ + ++IN+ +AV++++
Sbjct: 482 NGIMKDTLR----DCTHDERSCLSSL--QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 535
Query: 1782 QATEDVQE 1789
+ ++ QE
Sbjct: 536 DSNKEAQE 543
Score = 103 bits (248), Expect = 5e-21
Identities = 77/301 (25%), Positives = 142/301 (47%), Gaps = 28/301 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL + + Y + + +I L+ + ++LE + P L+ L Y + +
Sbjct: 269 PYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTS--LETALKYCNYM 326
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFV---AALCGAGGIQ--AFK 1313
FT +F +E ++K +A G +++F + W LD IV++S++ + A I +
Sbjct: 327 FTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIR 386
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ +VQA+P + N+ L+ ++ + I+A +GV+LF GK
Sbjct: 387 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL 445
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+ D+N C + F++ G A+L LFQV+T W IM
Sbjct: 446 --------------VCNDENPC-----EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMK 486
Query: 1434 DAI-DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLE 1492
D + D R + LY +N+ + V++ + ++ K+A E
Sbjct: 487 DTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAE 546
Query: 1493 M 1493
M
Sbjct: 547 M 547
Score = 70.5 bits (165), Expect = 6e-11
Identities = 41/121 (33%), Positives = 66/121 (54%), Gaps = 9/121 (7%)
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLD----FV-----VIALAYVTMGIDLG 222
IFT I+ E +KV++ G YLR +WN LD FV V++LA LG
Sbjct: 11 IFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILG 70
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ PGLK +V +I S+K + +++++ +F ++G+Q++
Sbjct: 71 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFK 130
Query: 283 G 283
G
Sbjct: 131 G 131
Score = 69.3 bits (162), Expect = 1e-10
Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 32/239 (13%)
Query: 1572 NMIFIVIFSSECLLKIFALRYH-----YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVS 1626
N IF IF E LK+ +L + Y WN+ D +V SI+ +V+S
Sbjct: 9 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 68
Query: 1627 PTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF 1686
+LRV+R+ + R LR++ A G++ ++ L SL + NI L+ IF I G+
Sbjct: 69 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 128
Query: 1687 F------------MHVKDKGG--------LDDVYNFKTFVQSMILLFQMSTSAGWDGVLD 1726
F ++ ++ + YNF Q+++ LF +++ GW ++
Sbjct: 129 FKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMY 188
Query: 1727 GIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATE 1785
++ D +P + Y +S+L+I V+NM++ V++EN+ + +
Sbjct: 189 NGLDAVAVDQQPVTNHNPWM-------LLYFISFLLIVSFFVLNMFVGVVVENFHKCRQ 240
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FI+A +G++LFGK + D P
Sbjct: 395 RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN--DENP 452
Query: 894 -DGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+G F +F +F+ +F+V G+ W M D +
Sbjct: 453 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTL 489
Score = 38.3 bits (85), Expect = 0.27
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GKNY 885
LR ++ P L L++ + ++ +GN+ + C IF ++G+QLF GK Y
Sbjct: 81 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 134
Score = 37.5 bits (83), Expect = 0.48
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 796 FVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
++++FIT I +N + M+L+H+N ++ ALK NY+
Sbjct: 289 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYM 326
>Z34820-1|CAA84351.1| 2155|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2155
Score = 302 bits (741), Expect = 9e-81
Identities = 209/698 (29%), Positives = 365/698 (52%), Gaps = 63/698 (9%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1616 LSD---------------IIEKYFVSPTLLRV----------VRVAKVGRVLRLVK---G 1647
LS+ I+ V + V + ++ RV+RLVK
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1359
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTF 1705
+GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF
Sbjct: 1360 GEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTF 1419
Query: 1706 VQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSYLV 1762
Q+++LLF+ +T W ++ + ++C P N CGS + + Y +S+ +
Sbjct: 1420 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYM 1478
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDF 1822
+ ++IN+++AVI++N+ T D L D + IW +DP+ I++ +
Sbjct: 1479 LCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTL 1537
Query: 1823 LDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 1538 LRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1575
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 935 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 994
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 995 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 1054
Query: 285 L 285
L
Sbjct: 1055 L 1055
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1351 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1410
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1411 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1443
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
Score = 35.1 bits (77), Expect = 2.6
Identities = 35/150 (23%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTI 248
+P Y D WN DF+++ + + + + N + AL IV G +I
Sbjct: 1273 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDAL----IVVG--SI 1323
Query: 249 VGAVIESVKNLRDVIILTMFSLSVFALMGL 278
V I V N + +++ +F +M L
Sbjct: 1324 VDIAITEVNNAEENSRISITFFRLFRVMRL 1353
>DQ494461-1|ABF69912.1| 2277|Homo sapiens T calcium channel alpha 1G
subunit variant 169 protein.
Length = 2277
Score = 301 bits (740), Expect = 1e-80
Identities = 184/612 (30%), Positives = 327/612 (53%), Gaps = 51/612 (8%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL +
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVG--- 1737
Query: 1663 PALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMST 1717
N+ LL L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST
Sbjct: 1738 ----NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1793
Query: 1718 SAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVIL 1777
W+G++ + +CD C + I Y +S+++ + +++N+ IAV++
Sbjct: 1794 GDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1844
Query: 1778 ENYSQATEDVQE 1789
++ ++ ++ +E
Sbjct: 1845 KHLEESNKEAKE 1856
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 85.4 bits (202), Expect = 2e-15
Identities = 74/300 (24%), Positives = 132/300 (44%), Gaps = 36/300 (12%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++ N+ L+ ++ + IFA +GV+LF
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLD-------TVGNLGLLFMLLFFIFAALGVELFGD-- 1760
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1761 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1802
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1803 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1860
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 5/98 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+RV ++A+ L + + M + +GNL + ++ FIFA +G++LFG D +
Sbjct: 1711 MRVLRIARVLKLLKMAVG-MRALLDTVGNLGLLFMLLFFIFAALGVELFGDLECD--ETH 1767
Query: 893 PDGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
P L R F +F +F+ +FRV G+ W M D +
Sbjct: 1768 PCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1805
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>U30707-1|AAB37235.1| 1871|Homo sapiens dihydropyridine receptor alpha
1 subunit protein.
Length = 1871
Score = 294 bits (721), Expect = 2e-78
Identities = 207/684 (30%), Positives = 358/684 (52%), Gaps = 61/684 (8%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
+R+ +++ T+F ++ ILLSS ALA ED + + IL + D FT +F +E
Sbjct: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
Query: 1267 MLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
+++K G + N + LD ++V VSLI+ + I K +R LR LR
Sbjct: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLE---SSAISVVKILRVLRVLR 903
Query: 1323 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT 1382
PLRA++R +G++ + AI +I N++LV + +FA +GVQLF GK+F+C D++
Sbjct: 904 PLRAINRAKGLK----CMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 959
Query: 1383 TLS-----HEIIPDKNACTLE--NYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
T + + D + +E + W +S +FD+V A + LF V+TF+GW Q++ A
Sbjct: 960 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1019
Query: 1436 IDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFM 1495
IDS PI + M ++ +N+F+G +I F EQ + + E+
Sbjct: 1020 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1079
Query: 1496 TEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMT 1554
+ Q Y A+K +PL+ IP+ ++ Q V+ IVT F+ ++ I LN + +
Sbjct: 1080 NQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYIVTSSYFEYLMFALIMLNTICLG 1132
Query: 1555 LDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILS 1613
+ HY QSE + + D LN+ F +IF+ E +LK+ A + YF PWN+FDF++V+ SI+
Sbjct: 1133 MQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIID 1192
Query: 1614 LVLSDIIEKYFVSPTLL----------------RV----VRVAKVGRVLRLVKGAKGIRT 1653
++LS+ I+ + S L R+ R+ +V R+++L+ A+G+RT
Sbjct: 1193 VILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1251
Query: 1654 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMIL 1711
LL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+TF Q+++L
Sbjct: 1252 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLL 1311
Query: 1712 LFQMSTSAG--WDGVLDGIINEEECD-LPDNERGSPGNCGSATIGITYLLSYLVISFLIV 1768
LF+ + + G W +L + CD D G CG+ Y +S+ ++ +V
Sbjct: 1312 LFRHACATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLV 1370
Query: 1769 INMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEP 1828
IN+++AVI++N+ T D L D + IW +DP+ I++ + L ++P
Sbjct: 1371 INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQP 1429
Query: 1829 PLQIHK--PNKY---KIISMDIPI 1847
PL K P++ +++ M++P+
Sbjct: 1430 PLGFGKFCPHRVACKRLVGMNMPL 1453
Score = 122 bits (294), Expect = 1e-26
Identities = 93/328 (28%), Positives = 160/328 (48%), Gaps = 58/328 (17%)
Query: 116 SATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------ 165
S AL+ L NP+R+ I I+ F I+ TI NC+ + MP
Sbjct: 26 SPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLG 85
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN-- 223
+E E F +++ E+A+K++A GF+ YLR WN LDF ++ L T+ ++ N
Sbjct: 86 LEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVI 145
Query: 224 ---------------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMF 268
+ ALR FRVLR L+ V+ VP L+ ++ ++ +++ L + +L +F
Sbjct: 146 QSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLF 205
Query: 269 SLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCG 328
+ ++A++GL+++ G + + C + G+ T EN E P
Sbjct: 206 MVIIYAIIGLELFKGKMHKTCYFI----GTDIVATVENEE--------------PSPCAR 247
Query: 329 NSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY------- 380
SG G C +G P PN+G T FD FG++ L+ ++ +T + W + LY
Sbjct: 248 TGSGRRCTINGSEC-RGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIG 306
Query: 381 ----QLFFVVIIFLGSFYLVNLILAIVA 404
++FV +I LGSF+++NL+L +++
Sbjct: 307 NEWPWIYFVTLILLGSFFILNLVLGVLS 334
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/256 (25%), Positives = 130/256 (50%), Gaps = 18/256 (7%)
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+IV K F +++L + LN L++ +H+ Q + + D N + + +F++E L+K++ L
Sbjct: 427 DIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGL 486
Query: 1591 RY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK 1649
YF+ +N FD VV IL ++L +E ++P + V+R ++ R+ ++ K
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILL---VESGAMTPLGISVLRCIRLLRIFKITKYWT 543
Query: 1650 GIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLD-DVYNFKTFVQS 1708
+ L+ +L S+ ++ ++ LLLFL + IF + GM F D + NF F Q+
Sbjct: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVRRSNFDNFPQA 603
Query: 1709 MILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLI 1767
+I +FQ+ T W ++ +GI+ P + Y + V I
Sbjct: 604 LISVFQVLTGEDWTSMMYNGIMAYRGPSYP------------GMLVCIYFIILFVCGNYI 651
Query: 1768 VINMYIAVILENYSQA 1783
++N+++A+ ++N ++A
Sbjct: 652 LLNVFLAIAVDNLAEA 667
Score = 91.1 bits (216), Expect = 4e-17
Identities = 87/320 (27%), Positives = 144/320 (45%), Gaps = 54/320 (16%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLP----HRPILQDILYYMDRIFTVI 1262
LR ++E FET ++ I + +ALA V+LP L L ++ F ++
Sbjct: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
Query: 1263 FFIEMLIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFV-----------AALCGAG 1307
F IE +K +A GF Y + W LDF IV + + + A + G
Sbjct: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
Query: 1308 GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1367
K +R R LRPLR +S + ++VV+N++ +A+ +F++ L+ L +I+AI+G++
Sbjct: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query: 1368 LFAGK-----YFKCVDMNHTTLSHEIIP-----DKNACTLENYTWENS---P----MNFD 1410
LF GK YF D+ T + E P CT+ P +FD
Sbjct: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFD 276
Query: 1411 HVGKAYLCLFQVATFKGWIQIM---NDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXX 1467
+ G + L ++Q T +GW ++ NDAI N + ++Y
Sbjct: 277 NFGFSMLTVYQCITMEGWTDVLYWVNDAIG------------NEWPWIYFVTLILLGSFF 324
Query: 1468 TLNLFIGVIIDNFNEQKKKA 1487
LNL +GV+ F ++++KA
Sbjct: 325 ILNLVLGVLSGEFTKEREKA 344
Score = 86.2 bits (204), Expect = 1e-15
Identities = 74/303 (24%), Positives = 137/303 (45%), Gaps = 35/303 (11%)
Query: 1201 WQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLP-HRPILQDILYYMDRI 1258
W+ W + R K ++++ F VI ++ L++L++A E + P LQDI +R+
Sbjct: 414 WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIA---NRV 470
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTL 1318
+F EML+K LG ++YF + + D +V ++ + GA +R +
Sbjct: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCI 530
Query: 1319 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD 1378
R LR + + +V +L+ +I SI ++LL+ +F +IF ++G+QLF G+Y D
Sbjct: 531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRY----D 586
Query: 1379 MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDS 1438
T + NFD+ +A + +FQV T + W +M + I +
Sbjct: 587 FEDTEVRRS--------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
Query: 1439 REVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED 1498
P + + +Y LN+F+ + +DN E + S + E+
Sbjct: 627 YRGPSYP----GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLT--SAQKAKAEE 680
Query: 1499 QKK 1501
+K+
Sbjct: 681 KKR 683
Score = 67.3 bits (157), Expect = 5e-10
Identities = 46/172 (26%), Positives = 87/172 (50%), Gaps = 16/172 (9%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIF 1588
IV K F+ II+L I N + + + + + + L+ L F+++FS E +KI
Sbjct: 47 IVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKII 106
Query: 1589 A--LRYH---YFVEPWNLFDFVVVMFSILSLVLSDI-IEKYFVSPTL-------LRVVRV 1635
A +H Y WN+ DF +V + +++L + + + +P ++ +R
Sbjct: 107 AYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRA 166
Query: 1636 AKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+V R LRLV G ++ +L ++ ++ LF+I LL+ ++ I+AI G+ F
Sbjct: 167 FRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
Score = 66.1 bits (154), Expect = 1e-09
Identities = 39/173 (22%), Positives = 90/173 (52%), Gaps = 9/173 (5%)
Query: 119 NALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVEST--------E 170
++ +I P N IR + I+ F+ FI+ IL++ + +S +
Sbjct: 777 SSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFD 836
Query: 171 VIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTF 230
+ FT ++T E +K+ G L ++ R+ +N LD +V+A++ ++MG++ ++ ++
Sbjct: 837 IGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKIL 896
Query: 231 RVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
RVLR L+ + + K + + ++ + +++++T +FA +G+Q++ G
Sbjct: 897 RVLRVLRPLRAINRAKGL-KCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 948
Score = 64.9 bits (151), Expect = 3e-09
Identities = 34/95 (35%), Positives = 58/95 (61%), Gaps = 6/95 (6%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LR+FK+ K W +L+ L++ + ++ ++ +L +L + I IF ++GMQLFG Y F
Sbjct: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRY-----DF 587
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD 926
D ++ R NF +F + + VF+VL GE W M++
Sbjct: 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYN 622
Score = 49.6 bits (113), Expect = 1e-04
Identities = 46/174 (26%), Positives = 88/174 (50%), Gaps = 18/174 (10%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIF 1579
P + + + IV F I+LFI L+ + + ++++ + +L + ++ F +F
Sbjct: 784 PTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVF 843
Query: 1580 SSECLLKI-----FALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPT-LLRVV 1633
+ E +LK+ F + + +N+ D +VV S++S+ L E +S +LRV+
Sbjct: 844 TVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGL----ESSAISVVKILRVL 899
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + AKG++ + A++ + NI L+ L+ F+FA G+ F
Sbjct: 900 RVL---RPLRAINRAKGLKCMFVAIS----TIGNIVLVTTLLQFMFACIGVQLF 946
Score = 38.7 bits (86), Expect = 0.21
Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 12/118 (10%)
Query: 818 NMDKDMDKALKSGNY-----LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 872
N+D D + S + +R+ KL + L+ ++ AL + ++ ++ FI
Sbjct: 1217 NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFI 1276
Query: 873 FAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLC--GE-WIESMWDC 927
+AV+GMQ+FGK + VD NF F + +++FR C GE W E + C
Sbjct: 1277 YAVIGMQMFGK--IALVDGTQIN--RNNNFQTFPQAVLLLFRHACATGEAWQEILLAC 1330
Score = 36.7 bits (81), Expect = 0.84
Identities = 15/57 (26%), Positives = 36/57 (63%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF 881
KAL++ LR +L P+L ++++ + + M L ++ ++ ++ I+A++G++LF
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF 218
>DQ494477-1|ABF69928.1| 2248|Homo sapiens T calcium channel alpha 1G
subunit variant 473-d75 protein.
Length = 2248
Score = 286 bits (701), Expect = 6e-76
Identities = 175/601 (29%), Positives = 320/601 (53%), Gaps = 58/601 (9%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +Q N+F+GV+++NF++ ++ E +
Sbjct: 1501 VDQQ-------------------------NMFVGVVVENFHKCRQHQEEEEARRREEKRL 1535
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRW----RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ ++ K+ +A +P + R + +V + T D+ I IGLN++TM ++
Sbjct: 1536 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1595
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLV 1615
HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1596 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1655
Query: 1616 LSDIIEKYF--VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1673
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL
Sbjct: 1656 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1715
Query: 1674 LVMFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGI 1728
L+ FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++
Sbjct: 1716 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1775
Query: 1729 INEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQ 1788
+ +CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +
Sbjct: 1776 L--RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1826
Query: 1789 E 1789
E
Sbjct: 1827 E 1827
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1556 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1613
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1614 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1673
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1674 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1731
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1732 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1773
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1774 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1831
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1682 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1739
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1740 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1776
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1564 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1613
>U79664-1|AAB49675.1| 949|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 949
Score = 276 bits (677), Expect = 5e-73
Identities = 177/621 (28%), Positives = 317/621 (51%), Gaps = 38/621 (6%)
Query: 1287 LDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1345
LDFI+V +L+ F G I K++R LR LRPL+ + R+ ++ V + +V ++
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 1346 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLSHEIIPDKNACTLENYT 1401
++FN+L+V ++F IFA++ VQLF GK+F C D ++ +KN +
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDRE 123
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W+ ++D+V A L LF V+T +GW Q++ ++D+ + P + M ++
Sbjct: 124 WKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYF 183
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPR 1520
+N+F+ +II F EQ K +E + E ++ + S KPL + +P+
Sbjct: 184 VVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQ 238
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFS 1580
+ Q +++ V F+ IM I LN + + + Y S + L N++F +FS
Sbjct: 239 NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS 298
Query: 1581 SECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ + LR+ R A
Sbjct: 299 LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE-FGNNFINLSFLRLFRAA--- 354
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDKGG 1695
R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F + V+D+
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 1696 LDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGS 1749
+D + NF+TF Q+++LLF+ +T W ++ ++ + CD N CG+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--KNSGILTRECGN 472
Query: 1750 ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPD 1809
Y +S++ + +++N+++AVI++N+ T D L D Y +W +DP
Sbjct: 473 -EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPA 530
Query: 1810 GSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDMMFCVDILDALTK 1864
I Y + L V+ PPL + K P++ +++ MD+P+ + + L AL +
Sbjct: 531 ACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIR 590
Query: 1865 ---DFFARKGNPIEETGDLEV 1882
D KG ++ D E+
Sbjct: 591 TALDIKIAKGGADKQQMDAEL 611
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 242 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 299
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 300 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 358
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 359 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 414
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 415 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 463
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 464 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 502
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 251 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 310
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 311 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 366
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 367 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 402
Score = 60.1 bits (139), Expect = 8e-08
Identities = 30/86 (34%), Positives = 53/86 (61%), Gaps = 7/86 (8%)
Query: 205 LDFVVIALAYVTM-------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 257
LDF+V++ A V G D+ + +LR RVLR LKT+ +P LK + V+ S+K
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 258 NLRDVIILTMFSLSVFALMGLQIYMG 283
N+ +++I+ M + +FA++ +Q++ G
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKG 89
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 454
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 17 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 76
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 77 FIFAVVAVQLFKGKFFHCTD 96
>DQ494458-1|ABF69909.1| 1758|Homo sapiens T calcium channel alpha 1G
subunit variant 145 protein.
Length = 1758
Score = 272 bits (667), Expect = 8e-72
Identities = 152/469 (32%), Positives = 259/469 (55%), Gaps = 18/469 (3%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1557
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1558 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1617
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1618 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1677
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1666
++PT++R++RV ++ RVL+L+K A G+R LL + +LP L+
Sbjct: 1678 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1726
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 74.1 bits (174), Expect = 5e-12
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 7/155 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1574 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1631
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1348
MR LR R L+ + GMR +++ ++QA+P ++
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1726
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1582 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631
>DQ494449-1|ABF69900.1| 1735|Homo sapiens T calcium channel alpha 1G
subunit variant 17 protein.
Length = 1735
Score = 272 bits (667), Expect = 8e-72
Identities = 152/469 (32%), Positives = 259/469 (55%), Gaps = 18/469 (3%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQK 1500
V +QPI N +M LY LN+F+GV+++NF++ ++ E ++
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH---QEEEEARRREE 1534
Query: 1501 KYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQ 1560
K ++K K K R + +V + T D+ I IGLN++TM ++HYQQ
Sbjct: 1535 KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQ 1594
Query: 1561 SETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDI 1619
+ L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L +I
Sbjct: 1595 PQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI 1654
Query: 1620 --IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1666
++PT++R++RV ++ RVL+L+K A G+R LL + +LP L+
Sbjct: 1655 EVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1703
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 74.1 bits (174), Expect = 5e-12
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 7/155 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1551 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1608
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1609 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1668
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1348
MR LR R L+ + GMR +++ ++QA+P ++
Sbjct: 1669 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1703
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1559 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1608
>DQ494466-1|ABF69917.1| 1765|Homo sapiens T calcium channel alpha 1G
subunit variant 209 protein.
Length = 1765
Score = 272 bits (666), Expect = 1e-71
Identities = 154/474 (32%), Positives = 265/474 (55%), Gaps = 21/474 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTL 1555
+KK + K+M ++ K R + +V + T D+ I IGLN++TM +
Sbjct: 1561 RRLEKKRRSKEKQM-AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1556 DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSL 1614
+HYQQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ +
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1615 VLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALF 1666
L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP L+
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1733
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 74.1 bits (174), Expect = 5e-12
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 7/155 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1581 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1638
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1348
MR LR R L+ + GMR +++ ++QA+P ++
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1733
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1589 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638
>U79668-1|AAB49678.1| 916|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 916
Score = 269 bits (659), Expect = 8e-71
Identities = 177/621 (28%), Positives = 316/621 (50%), Gaps = 38/621 (6%)
Query: 1287 LDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1345
LDFI+V +L+ F G I K++R LR LRPL+ + R+ ++ V + +V ++
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 1346 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLSHEIIPDKNACTLENYT 1401
++FN+L+V ++F IFA++ VQLF GK+F C D ++ +KN +
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDRE 123
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W+ ++D+V A L LF V+T +GW Q++ ++D+ + P + M ++
Sbjct: 124 WKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYF 183
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPR 1520
+N+F+ +II F EQ K +E + E ++ + S KPL + +P+
Sbjct: 184 VVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQ 238
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFS 1580
+ Q +++ V F+ IM I LN + + + Y S + L N++F +FS
Sbjct: 239 NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS 298
Query: 1581 SECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ + LR+ R A
Sbjct: 299 LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE-FGNNFINLSFLRLFRAA--- 354
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDKGG 1695
R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F + V+D+
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 1696 LDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGS 1749
+D + NF+TF Q+++LLF+ +T W ++ ++ + CD N CG+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--KNSGILTRECGN 472
Query: 1750 ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPD 1809
Y +S++ + +++N+++AVI++N+ T D L D Y +W +DP
Sbjct: 473 -EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPA 530
Query: 1810 GSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDMMFCVDILDALTK 1864
+ Y + L + PPL + K P + YK ++ MD+P+ + + L AL +
Sbjct: 531 AWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIR 590
Query: 1865 ---DFFARKGNPIEETGDLEV 1882
D KG ++ D E+
Sbjct: 591 TALDIKIAKGGADKQQMDAEL 611
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 242 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 299
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 300 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 358
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 359 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 414
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 415 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 463
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 464 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 502
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 251 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 310
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 311 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 366
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 367 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 402
Score = 60.1 bits (139), Expect = 8e-08
Identities = 30/86 (34%), Positives = 53/86 (61%), Gaps = 7/86 (8%)
Query: 205 LDFVVIALAYVTM-------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 257
LDF+V++ A V G D+ + +LR RVLR LKT+ +P LK + V+ S+K
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 258 NLRDVIILTMFSLSVFALMGLQIYMG 283
N+ +++I+ M + +FA++ +Q++ G
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKG 89
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 454
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 17 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 76
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 77 FIFAVVAVQLFKGKFFHCTD 96
>U79667-1|AAB49677.1| 1182|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 1182
Score = 269 bits (659), Expect = 8e-71
Identities = 177/621 (28%), Positives = 316/621 (50%), Gaps = 38/621 (6%)
Query: 1287 LDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1345
LDFI+V +L+ F G I K++R LR LRPL+ + R+ ++ V + +V ++
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 1346 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLSHEIIPDKNACTLENYT 1401
++FN+L+V ++F IFA++ VQLF GK+F C D ++ +KN +
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDRE 123
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W+ ++D+V A L LF V+T +GW Q++ ++D+ + P + M ++
Sbjct: 124 WKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYF 183
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPR 1520
+N+F+ +II F EQ K +E + E ++ + S KPL + +P+
Sbjct: 184 VVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQ 238
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFS 1580
+ Q +++ V F+ IM I LN + + + Y S + L N++F +FS
Sbjct: 239 NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS 298
Query: 1581 SECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ + LR+ R A
Sbjct: 299 LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE-FGNNFINLSFLRLFRAA--- 354
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDKGG 1695
R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F + V+D+
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 1696 LDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGS 1749
+D + NF+TF Q+++LLF+ +T W ++ ++ + CD N CG+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--KNSGILTRECGN 472
Query: 1750 ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPD 1809
Y +S++ + +++N+++AVI++N+ T D L D Y +W +DP
Sbjct: 473 -EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPA 530
Query: 1810 GSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDMMFCVDILDALTK 1864
+ Y + L + PPL + K P + YK ++ MD+P+ + + L AL +
Sbjct: 531 AWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIR 590
Query: 1865 ---DFFARKGNPIEETGDLEV 1882
D KG ++ D E+
Sbjct: 591 TALDIKIAKGGADKQQMDAEL 611
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 242 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 299
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 300 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 358
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 359 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 414
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 415 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 463
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 464 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 502
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 251 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 310
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 311 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 366
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 367 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 402
Score = 60.1 bits (139), Expect = 8e-08
Identities = 30/86 (34%), Positives = 53/86 (61%), Gaps = 7/86 (8%)
Query: 205 LDFVVIALAYVTM-------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 257
LDF+V++ A V G D+ + +LR RVLR LKT+ +P LK + V+ S+K
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 258 NLRDVIILTMFSLSVFALMGLQIYMG 283
N+ +++I+ M + +FA++ +Q++ G
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKG 89
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 454
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 17 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 76
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 77 FIFAVVAVQLFKGKFFHCTD 96
>U79665-1|AAB49676.1| 1194|Homo sapiens alpha1A-voltage-sensitive
calcium channel protein.
Length = 1194
Score = 269 bits (659), Expect = 8e-71
Identities = 177/621 (28%), Positives = 316/621 (50%), Gaps = 38/621 (6%)
Query: 1287 LDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1345
LDFI+V +L+ F G I K++R LR LRPL+ + R+ ++ V + +V ++
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 1346 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLSHEIIPDKNACTLENYT 1401
++FN+L+V ++F IFA++ VQLF GK+F C D ++ +KN +
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDRE 123
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W+ ++D+V A L LF V+T +GW Q++ ++D+ + P + M ++
Sbjct: 124 WKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYF 183
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPR 1520
+N+F+ +II F EQ K +E + E ++ + S KPL + +P+
Sbjct: 184 VVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQ 238
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFS 1580
+ Q +++ V F+ IM I LN + + + Y S + L N++F +FS
Sbjct: 239 NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS 298
Query: 1581 SECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ + LR+ R A
Sbjct: 299 LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE-FGNNFINLSFLRLFRAA--- 354
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDKGG 1695
R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F + V+D+
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 1696 LDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGS 1749
+D + NF+TF Q+++LLF+ +T W ++ ++ + CD N CG+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--KNSGILTRECGN 472
Query: 1750 ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPD 1809
Y +S++ + +++N+++AVI++N+ T D L D Y +W +DP
Sbjct: 473 -EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPA 530
Query: 1810 GSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDMMFCVDILDALTK 1864
+ Y + L + PPL + K P + YK ++ MD+P+ + + L AL +
Sbjct: 531 AWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIR 590
Query: 1865 ---DFFARKGNPIEETGDLEV 1882
D KG ++ D E+
Sbjct: 591 TALDIKIAKGGADKQQMDAEL 611
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 242 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 299
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 300 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 358
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 359 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 414
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 415 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 463
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 464 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 502
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 251 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 310
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 311 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 366
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 367 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 402
Score = 60.1 bits (139), Expect = 8e-08
Identities = 30/86 (34%), Positives = 53/86 (61%), Gaps = 7/86 (8%)
Query: 205 LDFVVIALAYVTM-------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 257
LDF+V++ A V G D+ + +LR RVLR LKT+ +P LK + V+ S+K
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 258 NLRDVIILTMFSLSVFALMGLQIYMG 283
N+ +++I+ M + +FA++ +Q++ G
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKG 89
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 454
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 17 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 76
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 77 FIFAVVAVQLFKGKFFHCTD 96
>U79663-1|AAB49674.1| 949|Homo sapiens alpha1A-voltage-dependent
calcium channel protein.
Length = 949
Score = 269 bits (659), Expect = 8e-71
Identities = 177/621 (28%), Positives = 316/621 (50%), Gaps = 38/621 (6%)
Query: 1287 LDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIP 1345
LDFI+V +L+ F G I K++R LR LRPL+ + R+ ++ V + +V ++
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 1346 SIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD----MNHTTLSHEIIPDKNACTLENYT 1401
++FN+L+V ++F IFA++ VQLF GK+F C D ++ +KN +
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDRE 123
Query: 1402 WENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXX 1461
W+ ++D+V A L LF V+T +GW Q++ ++D+ + P + M ++
Sbjct: 124 WKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYF 183
Query: 1462 XXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPR 1520
+N+F+ +II F EQ K +E + E ++ + S KPL + +P+
Sbjct: 184 VVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLEKNER--ACIDFAISAKPLTRHMPQ 238
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFS 1580
+ Q +++ V F+ IM I LN + + + Y S + L N++F +FS
Sbjct: 239 NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFS 298
Query: 1581 SECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVG 1639
EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ + LR+ R A
Sbjct: 299 LECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE-FGNNFINLSFLRLFRAA--- 354
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----MHVKDKGG 1695
R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F + V+D+
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 1696 LDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGS 1749
+D + NF+TF Q+++LLF+ +T W ++ ++ + CD N CG+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--KNSGILTRECGN 472
Query: 1750 ATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPD 1809
Y +S++ + +++N+++AVI++N+ T D L D Y +W +DP
Sbjct: 473 -EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPA 530
Query: 1810 GSQYIRYDQLSDFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDMMFCVDILDALTK 1864
+ Y + L + PPL + K P + YK ++ MD+P+ + + L AL +
Sbjct: 531 AWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIR 590
Query: 1865 ---DFFARKGNPIEETGDLEV 1882
D KG ++ D E+
Sbjct: 591 TALDIKIAKGGADKQQMDAEL 611
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 242 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 299
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 300 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 358
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 359 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 414
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 415 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 463
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 464 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 502
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 251 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 310
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 311 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 366
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 367 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 402
Score = 60.1 bits (139), Expect = 8e-08
Identities = 30/86 (34%), Positives = 53/86 (61%), Gaps = 7/86 (8%)
Query: 205 LDFVVIALAYVTM-------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVK 257
LDF+V++ A V G D+ + +LR RVLR LKT+ +P LK + V+ S+K
Sbjct: 4 LDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 63
Query: 258 NLRDVIILTMFSLSVFALMGLQIYMG 283
N+ +++I+ M + +FA++ +Q++ G
Sbjct: 64 NVFNILIVYMLFMFIFAVVAVQLFKG 89
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 355 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 414
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 415 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 454
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 17 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 76
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 77 FIFAVVAVQLFKGKFFHCTD 96
>DQ494462-1|ABF69913.1| 1776|Homo sapiens T calcium channel alpha 1G
subunit variant 177 protein.
Length = 1776
Score = 267 bits (654), Expect = 3e-70
Identities = 155/484 (32%), Positives = 265/484 (54%), Gaps = 30/484 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1560
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1561 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1620
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1621 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1680
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1681 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1740
Query: 1663 PALF 1666
P L+
Sbjct: 1741 PQLW 1744
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1500 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 74.1 bits (174), Expect = 5e-12
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 7/155 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1649
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1650 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1709
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1348
MR LR R L+ + GMR +++ ++QA+P ++
Sbjct: 1710 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1744
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1649
>DQ494452-1|ABF69903.1| 1753|Homo sapiens T calcium channel alpha 1G
subunit variant 49 protein.
Length = 1753
Score = 267 bits (654), Expect = 3e-70
Identities = 155/484 (32%), Positives = 265/484 (54%), Gaps = 30/484 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1662
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL + +L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1717
Query: 1663 PALF 1666
P L+
Sbjct: 1718 PQLW 1721
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 74.1 bits (174), Expect = 5e-12
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 7/155 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIF 1348
MR LR R L+ + GMR +++ ++QA+P ++
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQLW 1721
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>DQ494451-1|ABF69902.1| 1746|Homo sapiens T calcium channel alpha 1G
subunit variant 33 protein.
Length = 1746
Score = 262 bits (642), Expect = 9e-69
Identities = 153/476 (32%), Positives = 260/476 (54%), Gaps = 30/476 (6%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF-----NEQKKKAGGSLEMFM 1495
V +QPI N +M LY LN+F+GV+++NF ++++++A E +
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL 1537
Query: 1496 TEDQKKYYNAM--KKMGSKKPLKAIPRPRWRP--------QAIVFEIVTDKKFDMIIMLF 1545
+KK N M + S A + +P + +V + T D+ I
Sbjct: 1538 RRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV 1597
Query: 1546 IGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDF 1604
IGLN++TM ++HYQQ + L N IF VIF E + K+ A + +F + WN D
Sbjct: 1598 IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1657
Query: 1605 VVVMFSILSLVLSDI--IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1658
+V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K A G+R LL L
Sbjct: 1658 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTL 1713
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 92.3 bits (219), Expect = 2e-17
Identities = 70/297 (23%), Positives = 144/297 (48%), Gaps = 36/297 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEE 1732
++ +K + YNF Q+++ LF +++ GW ++ ++
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476
Query: 1733 ECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
D +P + Y +S+L+I V+NM++ V++EN+ + + +E
Sbjct: 1477 GVDQQPIMNHNPWM-------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 66.5 bits (155), Expect = 9e-10
Identities = 41/147 (27%), Positives = 71/147 (48%), Gaps = 7/147 (4%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E H IL + L + I
Sbjct: 1569 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME--HYQQPQILDEALKICNYI 1626
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1627 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1686
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNAL 1340
MR LR R L+ + GMR +++ L
Sbjct: 1687 IMRVLRIARVLKLLKMAVGMRALLDTL 1713
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1626
>AF049618-1|AAD20439.1| 324|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 324
Score = 254 bits (622), Expect = 2e-66
Identities = 121/247 (48%), Positives = 175/247 (70%), Gaps = 7/247 (2%)
Query: 1671 LLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIIN 1730
LLFLVMFIF+IFGMS F +VK + G+DD++NF+TF SMI LFQ++TSAGWDG+L I+N
Sbjct: 1 LLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILN 60
Query: 1731 EE-ECDLPDNERGS--PGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDV 1787
+C L GS G+CG+ ++GI + +SY++ISFLIV+NMYIA+ILEN+S ATE+
Sbjct: 61 RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEES 120
Query: 1788 QEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHKPNKYKIISMDIPI 1847
+ L++DD++ +YEIW++FDPD +Q+I Y +L+DF D LE PL++ KPN ++I+MD+P+
Sbjct: 121 ADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPM 180
Query: 1848 CRGDMMFCVDILDALTKDFFARKGNPIEETGDLE----VGRPEEAGYEPVSSTLWRQREE 1903
GD + C+DIL A TK G +E P + YEP+++TL R++EE
Sbjct: 181 VSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEE 240
Query: 1904 YCARLIQ 1910
A ++Q
Sbjct: 241 VSAVVLQ 247
>AF038871-1|AAG43105.1| 209|Homo sapiens type IV sodium channel alpha
polypeptide protein.
Length = 209
Score = 243 bits (594), Expect = 6e-63
Identities = 118/210 (56%), Positives = 155/210 (73%), Gaps = 7/210 (3%)
Query: 1236 ALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVS 1295
A ED+++ R +++ IL Y D++FT IF +EML+KW+A GF+ YFTNAWCWLDF+IV VS
Sbjct: 1 AFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVS 60
Query: 1296 LINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1355
+I+ VA G + K++RTLRALRPLRA+SR +GMRVVVNAL+ AIPSI NVLLVCL
Sbjct: 61 IISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 120
Query: 1356 IFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEI--IPDKNACTLENYT----WENSPMNF 1409
IFWLIF+IMGV LFAGK++ C++ T+ +I + +K+ C +T W N +N+
Sbjct: 121 IFWLIFSIMGVNLFAGKFYYCINTT-TSERFDISEVNNKSECESLMHTGQVRWLNVKVNY 179
Query: 1410 DHVGKAYLCLFQVATFKGWIQIMNDAIDSR 1439
D+VG YL L QVATFKGW+ IM A+DSR
Sbjct: 180 DNVGLGYLSLLQVATFKGWMDIMYAAVDSR 209
Score = 70.1 bits (164), Expect = 7e-11
Identities = 33/124 (26%), Positives = 75/124 (60%), Gaps = 10/124 (8%)
Query: 166 VESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI------ 219
+E + +FT I+ E +K +A GF + Y +AW WLDF+++ ++ +++
Sbjct: 17 LEYADKVFTYIFIMEMLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYS 72
Query: 220 DLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQ 279
+LG + +LRT R LR L+ ++ G++ +V A++ ++ ++ +V+++ + +F++MG+
Sbjct: 73 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 132
Query: 280 IYMG 283
++ G
Sbjct: 133 LFAG 136
Score = 66.5 bits (155), Expect = 9e-10
Identities = 39/132 (29%), Positives = 72/132 (54%), Gaps = 4/132 (3%)
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLV 1615
+ +Q +L+Y + +F IF E LLK A + YF W DF++V SI+SLV
Sbjct: 6 YIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLV 65
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++ + + P ++ +R + R LR + +G+R ++ AL ++P++ N+ L+ +
Sbjct: 66 -ANWLGYSELGP--IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIF 122
Query: 1676 MFIFAIFGMSFF 1687
IF+I G++ F
Sbjct: 123 WLIFSIMGVNLF 134
>Z34819-1|CAA84350.1| 2166|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2166
Score = 226 bits (553), Expect = 5e-58
Identities = 139/423 (32%), Positives = 234/423 (55%), Gaps = 22/423 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + YF +PWN+FDF++V+ SI+ ++
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1616 LSD 1618
LS+
Sbjct: 1300 LSE 1302
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 134 bits (323), Expect = 4e-30
Identities = 93/340 (27%), Positives = 176/340 (51%), Gaps = 29/340 (8%)
Query: 1539 DMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFV 1596
+++ MLF GL + M L ++ FS D N+ +I + I + HYF
Sbjct: 1252 NILNMLFTGLFTVEMILKLIAFKPKGYFS---DPWNVFDFLIVIGSIIDVILSETNHYFC 1308
Query: 1597 EPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLV 1645
+ WN FD ++V+ SI+ + ++++ E SP++ + R+ +V R+++L+
Sbjct: 1309 DAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLL 1368
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFK 1703
+GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+
Sbjct: 1369 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQ 1428
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSY 1760
TF Q+++LLF+ +T W ++ + ++C P N CGS + + Y +S+
Sbjct: 1429 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISF 1487
Query: 1761 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLS 1820
++ ++IN+++AVI++N+ T D L D + IW +DP+ I++ +
Sbjct: 1488 YMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1546
Query: 1821 DFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 1547 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1586
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/162 (27%), Positives = 87/162 (53%), Gaps = 12/162 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIFSSECLLKIFA- 1589
IV D F +I+ FI L+ +++ + Q +F + +L Y +++F IF+ E LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 955
Query: 1590 ---LRYHYFVEPW-NLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
L F + N+ D +VV S++S + + +++++RV +V R LR +
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS------AINVVKILRVLRVLRPLRAI 1009
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
AKG++ ++ + +++ + NI ++ L+ F+FA G+ F
Sbjct: 1010 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF 1051
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/323 (22%), Positives = 141/323 (43%), Gaps = 76/323 (23%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 1211 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 1268
Query: 1270 K-------------WLALGF---------------QKYFTNAWCWLDFIIVMVSLINF-V 1300
K W F YF +AW D +IV+ S+++ +
Sbjct: 1269 KLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAI 1328
Query: 1301 AALCGAGGIQAFKTM-------------RTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
+ A Q +M R R +R ++ +SR +G+R ++ +++ ++
Sbjct: 1329 TEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQAL 1388
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPM 1407
V L+ ++ + I+A++G+Q+F GK + +N TT EI N
Sbjct: 1389 PYVALLIVMLFFIYAVIGMQVF-GK----IALNDTT---EI---------------NRNN 1425
Query: 1408 NFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVG--RQPIRET-------NIYMYLYXX 1458
NF +A L LF+ AT + W IM + ++ +P T + + Y
Sbjct: 1426 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1485
Query: 1459 XXXXXXXXXTLNLFIGVIIDNFN 1481
+NLF+ VI+DNF+
Sbjct: 1486 SFYMLCAFLIINLFVAVIMDNFD 1508
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1362 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1421
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1422 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1454
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
Score = 34.3 bits (75), Expect = 4.5
Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVI 210
+P Y D WN DF+++
Sbjct: 1273 ---FKPKGYFSDPWNVFDFLIV 1291
>AY830713-1|AAX37356.1| 2179|Homo sapiens voltage-dependent L-type
calcium channel alpha-1C subunit splice variant protein.
Length = 2179
Score = 221 bits (541), Expect = 2e-56
Identities = 136/424 (32%), Positives = 232/424 (54%), Gaps = 22/424 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
+K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 949 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 1005
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 1006 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 1065
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 1066 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 1125
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 1126 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 1185
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 1186 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY QS F ++ LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1616 LSDI 1619
++++
Sbjct: 1300 ITEV 1303
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 113 bits (273), Expect = 5e-24
Identities = 70/241 (29%), Positives = 130/241 (53%), Gaps = 16/241 (6%)
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+S T R+ RV R+++L+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM
Sbjct: 1345 ISITFFRLFRVM---RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1401
Query: 1685 SFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDN 1739
F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++C P N
Sbjct: 1402 QVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSN 1461
Query: 1740 ERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMY 1799
CGS + + Y +S+ ++ ++IN+++AVI++N+ T D L D +
Sbjct: 1462 STEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEF 1519
Query: 1800 YEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMM 1853
IW +DP+ I++ + L ++PPL K P++ +++SM++P+ G +M
Sbjct: 1520 KRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVM 1579
Query: 1854 F 1854
F
Sbjct: 1580 F 1580
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 74.9 bits (176), Expect = 3e-12
Identities = 37/119 (31%), Positives = 72/119 (60%), Gaps = 3/119 (2%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNLAA 226
+++FT I+T E A+K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 937 DIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKI 996
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G L
Sbjct: 997 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/162 (27%), Positives = 87/162 (53%), Gaps = 12/162 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIFSSECLLKIFA- 1589
IV D F +I+ FI L+ +++ + Q +F + +L Y +++F IF+ E LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 955
Query: 1590 ---LRYHYFVEPW-NLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
L F + N+ D +VV S++S + + +++++RV +V R LR +
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS------AINVVKILRVLRVLRPLRAI 1009
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
AKG++ ++ + +++ + NI ++ L+ F+FA G+ F
Sbjct: 1010 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF 1051
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 45.2 bits (102), Expect = 0.002
Identities = 44/175 (25%), Positives = 81/175 (46%), Gaps = 32/175 (18%)
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1375
R R +R ++ +SR +G+R ++ +++ ++ V L+ ++ + I+A++G+Q+F GK
Sbjct: 1351 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GK--- 1406
Query: 1376 CVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
+ +N TT EI N NF +A L LF+ AT + W IM
Sbjct: 1407 -IALNDTT---EI---------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447
Query: 1436 IDSREVG--RQPIRET-------NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFN 1481
+ ++ +P T + + Y +NLF+ VI+DNF+
Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 1502
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1356 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1415
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1416 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1448
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
Score = 34.3 bits (75), Expect = 4.5
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 11/91 (12%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1272
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGI 219
+P Y DAWN D +++ + V + I
Sbjct: 1273 ---FKPKHYFCDAWNTFDALIVVGSIVDIAI 1300
>AC005305-1|AAC26839.1| 419|Homo sapiens CACNL1A4 protein.
Length = 419
Score = 217 bits (530), Expect = 3e-55
Identities = 130/423 (30%), Positives = 222/423 (52%), Gaps = 17/423 (4%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIE 1266
LR ++ YFE ++ +I +SS+ALA ED P+ P ++L Y D +FT +F E
Sbjct: 1 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAP-RNNVLRYFDYVFTGVFTFE 59
Query: 1267 MLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAG-GIQAFKTMRTLRAL 1321
M+IK + LG YF + W LDFI+V +L+ F G I K++R LR L
Sbjct: 60 MVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 119
Query: 1322 RPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVD--- 1378
RPL+ + R+ ++ V + +V ++ ++FN+L+V ++F IFA++ VQLF GK+F C D
Sbjct: 120 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESK 179
Query: 1379 -MNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAID 1437
++ +KN + W+ ++D+V A L LF V+T +GW Q++ ++D
Sbjct: 180 EFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVD 239
Query: 1438 SREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTE 1497
+ + P + M ++ +N+F+ +II F EQ K +E + E
Sbjct: 240 ATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDK---MMEEYSLE 296
Query: 1498 DQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
++ + S KPL + +P+ + Q +++ V F+ IM I LN + + +
Sbjct: 297 KNER--ACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK 354
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
Y S + L N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI ++
Sbjct: 355 FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDIL 414
Query: 1616 LSD 1618
+++
Sbjct: 415 VTE 417
Score = 101 bits (243), Expect = 2e-20
Identities = 55/169 (32%), Positives = 95/169 (56%), Gaps = 15/169 (8%)
Query: 130 IRRVAIYILVHPLFSLFIITTILVNCILM-----IMPTTP---TVESTEVIFTGIYTFES 181
+RR+ YIL F + I+ I ++ I + + P P + + +FTG++TFE
Sbjct: 1 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 60
Query: 182 AVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTM-------GIDLGNLAALRTFRVLR 234
+K++ G +L Y RD WN LDF+V++ A V G D+ + +LR RVLR
Sbjct: 61 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 120
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
LKT+ +P LK + V+ S+KN+ +++I+ M + +FA++ +Q++ G
Sbjct: 121 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 169
Score = 66.1 bits (154), Expect = 1e-09
Identities = 42/162 (25%), Positives = 86/162 (53%), Gaps = 8/162 (4%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTL-DHYQQSETFSAVLDYLNMIFIVIFSSECLLKIF-- 1588
I+ + F+M I++ I ++ + + D Q + + VL Y + +F +F+ E ++K+
Sbjct: 8 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 67
Query: 1589 ALRYH---YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
L H YF + WN+ DF+VV ++++ + + ++ ++ +RV +V R L+ +
Sbjct: 68 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINT--IKSLRVLRVLRPLKTI 125
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
K ++ + + SL +FNI ++ L MFIFA+ + F
Sbjct: 126 KRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLF 167
Score = 44.4 bits (100), Expect = 0.004
Identities = 23/100 (23%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 322 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 379
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCG 1305
E ++K +A G YF +AW DF+ V+ S+ + + G
Sbjct: 380 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG 419
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 11/80 (13%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 331 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 390
Query: 191 ILQPFTYLRDAWNWLDFVVI 210
+ Y RDAWN DFV +
Sbjct: 391 L----NYFRDAWNIFDFVTV 406
Score = 34.7 bits (76), Expect = 3.4
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 813 ALDHHNMDKDMD--KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIII 870
A ++ KD++ K+L+ LR K K P L + + ++ + N+ V + +
Sbjct: 97 AFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFM 156
Query: 871 FIFAVMGMQLFGKNYVDYVD 890
FIFAV+ +QLF + D
Sbjct: 157 FIFAVVAVQLFKGKFFHCTD 176
>Z26295-1|CAA81219.1| 683|Homo sapiens L-type Ca2+ channel isoform 1,
neuronal subform protein.
Length = 683
Score = 215 bits (524), Expect = 2e-54
Identities = 135/475 (28%), Positives = 253/475 (53%), Gaps = 31/475 (6%)
Query: 1403 ENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXX 1462
ENS +FD+V A + LF V+TF+GW +++ +IDS + PI + + ++
Sbjct: 1 ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYII 60
Query: 1463 XXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPR 1522
+N+F+G +I F EQ ++ + E+ + Q Y A+K +PL+ P+
Sbjct: 61 IIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY-ALK----ARPLRRY-IPK 114
Query: 1523 WRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSE 1582
+ Q V+ +V F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E
Sbjct: 115 NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 174
Query: 1583 CLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------L 1630
+LK+ A + HYF + WN FD ++V+ SI+ + ++++ E SP++ +
Sbjct: 175 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 234
Query: 1631 RVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--M 1688
R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM F +
Sbjct: 235 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 294
Query: 1689 HVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPG 1745
+ D ++ NF+TF Q+++LLF+ +T W ++ + ++C P N
Sbjct: 295 ALNDTTEINRNNNFQTFPQAVLLLFKCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 354
Query: 1746 NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQR 1805
CGS + + Y +S+ ++ ++IN+++AVI++N+ T D L D + IW
Sbjct: 355 PCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAE 412
Query: 1806 FDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
+DP+ I++ + L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 413 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 467
Score = 80.6 bits (190), Expect = 5e-14
Identities = 73/295 (24%), Positives = 142/295 (48%), Gaps = 48/295 (16%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 120 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 177
Query: 1270 KWLALGFQKYFTNAWCWLDFIIVMVSLINF-VAALCGAGGIQAFKTM------------- 1315
K +A + YF +AW D +IV+ S+++ + + A Q +M
Sbjct: 178 KLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFF 237
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1375
R R +R ++ +SR +G+R ++ +++ ++ V L+ ++ + I+A++G+Q+F GK
Sbjct: 238 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GK--- 293
Query: 1376 CVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
+ +N TT EI N NF +A L LF+ AT + W IM
Sbjct: 294 -IALNDTT---EI---------------NRNNNFQTFPQAVLLLFKCATGEAWQDIMLAC 334
Query: 1436 IDSREVG--RQPIRET-------NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFN 1481
+ ++ +P T + + Y +NLF+ VI+DNF+
Sbjct: 335 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 389
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 123 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 181
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 182 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 238
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 239 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 291
Score = 42.3 bits (95), Expect = 0.017
Identities = 26/97 (26%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 243 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 302
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++F+ GE W + M CM
Sbjct: 303 NRNN----NFQTFPQAVLLLFKCATGEAWQDIMLACM 335
>Z34821-1|CAA84352.1| 2186|Homo sapiens voltage-dependent L-type Ca
channel alpha 1 subunit protein.
Length = 2186
Score = 210 bits (514), Expect = 3e-53
Identities = 141/443 (31%), Positives = 235/443 (53%), Gaps = 42/443 (9%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALG---FQKYFT---------------------NAWCWLDFIIVMVSLINFVAAL 1303
+K L F FT N + LD ++V VSLI+F
Sbjct: 949 ALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ- 1007
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+ I K +R LR LRPLRA++R +G++ VV + AI +I N+++V + +FA
Sbjct: 1008 --SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 1364 MGVQLFAGKYFKCVDMNHTTLSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAY 1416
+GVQLF GK + C D + T + I K+ ++ +WENS +FD+V A
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125
Query: 1417 LCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVI 1476
+ LF V+TF+GW +++ +IDS + PI + + ++ +N+F+G +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185
Query: 1477 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDK 1536
I F EQ ++ + E+ + Q Y A+K +PL+ P+ + Q V+ +V
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNST 1239
Query: 1537 KFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYF 1595
F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E +LK+ A + YF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1596 VEPWNLFDFVVVMFSILSLVLSD 1618
+PWN+FDF++V+ SI+ ++LS+
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSE 1322
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 134 bits (323), Expect = 4e-30
Identities = 93/340 (27%), Positives = 176/340 (51%), Gaps = 29/340 (8%)
Query: 1539 DMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFV 1596
+++ MLF GL + M L ++ FS D N+ +I + I + HYF
Sbjct: 1272 NILNMLFTGLFTVEMILKLIAFKPKGYFS---DPWNVFDFLIVIGSIIDVILSETNHYFC 1328
Query: 1597 EPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLV 1645
+ WN FD ++V+ SI+ + ++++ E SP++ + R+ +V R+++L+
Sbjct: 1329 DAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLL 1388
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFK 1703
+GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+
Sbjct: 1389 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQ 1448
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSY 1760
TF Q+++LLF+ +T W ++ + ++C P N CGS + + Y +S+
Sbjct: 1449 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISF 1507
Query: 1761 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLS 1820
++ ++IN+++AVI++N+ T D L D + IW +DP+ I++ +
Sbjct: 1508 YMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1566
Query: 1821 DFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 1567 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1606
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/138 (28%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
Query: 151 ILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVI 210
I+ I I + + + +FT I+T E +K+ A G L ++ R+ +N LD +V+
Sbjct: 938 IVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 997
Query: 211 ALAYVTMGID---LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTM 267
+++ ++ GI + + LR RVLR L+ + GLK +V V +++ + +++I+T
Sbjct: 998 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057
Query: 268 FSLSVFALMGLQIYMGVL 285
+FA +G+Q++ G L
Sbjct: 1058 LLQFMFACIGVQLFKGKL 1075
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/323 (22%), Positives = 141/323 (43%), Gaps = 76/323 (23%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 1231 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 1288
Query: 1270 K-------------WLALGF---------------QKYFTNAWCWLDFIIVMVSLINF-V 1300
K W F YF +AW D +IV+ S+++ +
Sbjct: 1289 KLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAI 1348
Query: 1301 AALCGAGGIQAFKTM-------------RTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
+ A Q +M R R +R ++ +SR +G+R ++ +++ ++
Sbjct: 1349 TEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQAL 1408
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPM 1407
V L+ ++ + I+A++G+Q+F GK + +N TT EI N
Sbjct: 1409 PYVALLIVMLFFIYAVIGMQVF-GK----IALNDTT---EI---------------NRNN 1445
Query: 1408 NFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVG--RQPIRET-------NIYMYLYXX 1458
NF +A L LF+ AT + W IM + ++ +P T + + Y
Sbjct: 1446 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1505
Query: 1459 XXXXXXXXXTLNLFIGVIIDNFN 1481
+NLF+ VI+DNF+
Sbjct: 1506 SFYMLCAFLIINLFVAVIMDNFD 1528
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/177 (25%), Positives = 91/177 (51%), Gaps = 22/177 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIFSSECLLKIFAL 1590
IV D F +I+ FI L+ +++ + Q +F + +L Y +++F IF+ E LKI
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGN 955
Query: 1591 RYHYFVEPWNLFDFVVVM----------------FSILSL-VLSDIIEKYFVSPTLLRVV 1633
+ F + L + ++ M F+IL L V+S + + + + + VV
Sbjct: 956 ADYVFTSIFTL-EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 1014
Query: 1634 RVAKVGRVLRLVKG---AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +V RVLR ++ AKG++ ++ + +++ + NI ++ L+ F+FA G+ F
Sbjct: 1015 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF 1071
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1382 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1441
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1442 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1474
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
Score = 34.3 bits (75), Expect = 4.5
Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1292
Query: 189 GFILQPFTYLRDAWNWLDFVVI 210
+P Y D WN DF+++
Sbjct: 1293 ---FKPKGYFSDPWNVFDFLIV 1311
>M92269-1|AAA17030.1| 2221|Homo sapiens L-type calcium channel (HFCC)
protein.
Length = 2221
Score = 210 bits (514), Expect = 3e-53
Identities = 141/443 (31%), Positives = 235/443 (53%), Gaps = 42/443 (9%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL+Y D +FT IF IE+
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEI 948
Query: 1268 LIKWLALG---FQKYFT---------------------NAWCWLDFIIVMVSLINFVAAL 1303
+K L F FT N + LD ++V VSLI+F
Sbjct: 949 ALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ- 1007
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+ I K +R LR LRPLRA++R +G++ VV + AI +I N+++V + +FA
Sbjct: 1008 --SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 1364 MGVQLFAGKYFKCVDMNHTTLSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAY 1416
+GVQLF GK + C D + T + I K+ ++ +WENS +FD+V A
Sbjct: 1066 IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAM 1125
Query: 1417 LCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVI 1476
+ LF V+TF+GW +++ +IDS + PI + + ++ +N+F+G +
Sbjct: 1126 MALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV 1185
Query: 1477 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDK 1536
I F EQ ++ + E+ + Q Y A+K +PL+ P+ + Q V+ +V
Sbjct: 1186 IVTFQEQGEQEYKNCELDKNQRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNST 1239
Query: 1537 KFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYF 1595
F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E +LK+ A + YF
Sbjct: 1240 YFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYF 1299
Query: 1596 VEPWNLFDFVVVMFSILSLVLSD 1618
+PWN+FDF++V+ SI+ ++LS+
Sbjct: 1300 SDPWNVFDFLIVIGSIIDVILSE 1322
Score = 134 bits (325), Expect = 2e-30
Identities = 96/323 (29%), Positives = 169/323 (52%), Gaps = 58/323 (17%)
Query: 120 ALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 169
AL L NPIRR I I+ F + I+ TI NC+ + + T +E
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID--------- 220
E +F I+T E+ +KV+A G + P YLR+ WN LDF+++ + + ++
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 221 -LG------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
LG ++ ALR FRVLR L+ V+ VP L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 274 ALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGA 333
A++GL+++MG + + C + ++G ++ E+ C ET G G
Sbjct: 283 AIIGLELFMGKMHKTC---YNQEGI-ADVPAEDDPSPCALET---GHG------------ 323
Query: 334 GQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWEN-LY-----------Q 381
QC+ G VC G+ P +G T+FD F +A L+ F+ +T + W + LY
Sbjct: 324 RQCQNGTVCKPGW-DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW 382
Query: 382 LFFVVIIFLGSFYLVNLILAIVA 404
++FV +I +GSF+++NL+L +++
Sbjct: 383 IYFVTLIIIGSFFVLNLVLGVLS 405
Score = 134 bits (323), Expect = 4e-30
Identities = 93/340 (27%), Positives = 176/340 (51%), Gaps = 29/340 (8%)
Query: 1539 DMIIMLFIGLNMLTMTLD--HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFV 1596
+++ MLF GL + M L ++ FS D N+ +I + I + HYF
Sbjct: 1272 NILNMLFTGLFTVEMILKLIAFKPKGYFS---DPWNVFDFLIVIGSIIDVILSETNHYFC 1328
Query: 1597 EPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGRVLRLV 1645
+ WN FD ++V+ SI+ + ++++ E SP++ + R+ +V R+++L+
Sbjct: 1329 DAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLL 1388
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDDVYNFK 1703
+GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++ NF+
Sbjct: 1389 SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQ 1448
Query: 1704 TFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSATIGITYLLSY 1760
TF Q+++LLF+ +T W ++ + ++C P N CGS + + Y +S+
Sbjct: 1449 TFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISF 1507
Query: 1761 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLS 1820
++ ++IN+++AVI++N+ T D L D + IW +DP+ I++ +
Sbjct: 1508 YMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVV 1566
Query: 1821 DFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMMF 1854
L ++PPL K P++ +++SM++P+ G +MF
Sbjct: 1567 TLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1606
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 694
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 742
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 743 ILLNVFLAIAVDNLADA 759
Score = 101 bits (241), Expect = 3e-20
Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 40/312 (12%)
Query: 1207 LRLKTFKLIENTYFETAVITMILLSSLALAL-----EDVHLPHRPILQDILYYMDRIFTV 1261
+R ++E FE ++ I + +ALA+ ED L+ + Y IFTV
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTV 172
Query: 1262 IFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVA----------ALCGAGGIQA 1311
F++++ L Y N W LDFIIV+V L + + AL G G
Sbjct: 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD 232
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
K +R R LRPLR +S + ++VV+N++++A+ + ++ L+ L +I+AI+G++LF G
Sbjct: 233 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMG 292
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLE--------NYT-----WE---NSPMNFDHVGKA 1415
K K D + C LE N T W+ + NFD+ A
Sbjct: 293 KMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFA 352
Query: 1416 YLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGV 1475
L +FQ T +GW ++ D+ VGR + ++Y LNL +GV
Sbjct: 353 MLTVFQCITMEGWTDVLYWVNDA--VGRD-------WPWIYFVTLIIIGSFFVLNLVLGV 403
Query: 1476 IIDNFNEQKKKA 1487
+ F+++++KA
Sbjct: 404 LSGEFSKEREKA 415
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 503 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 560
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 561 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 620
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 678
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 679 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 716
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 717 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 772
Query: 1497 EDQKK 1501
+++KK
Sbjct: 773 KERKK 777
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/213 (26%), Positives = 103/213 (48%), Gaps = 20/213 (9%)
Query: 1496 TEDQKKYYNAMKKMGS----KKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLNM 1550
T+ +++ Y KK GS + P + P + IV K F++II+L I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANC 138
Query: 1551 LTMTLD---HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFA--LRYH---YFVEPWNLF 1602
+ + + S ++ L+ + +F++IF+ E LK+ A L +H Y WNL
Sbjct: 139 VALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLL 198
Query: 1603 DFVVVMFSILSLVLSDIIEKYFVSPTL-------LRVVRVAKVGRVLRLVKGAKGIRTLL 1655
DF++V+ + S +L + + ++ +R +V R LRLV G ++ +L
Sbjct: 199 DFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 258
Query: 1656 FALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
++ ++ L +I LL+ V+ I+AI G+ FM
Sbjct: 259 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/138 (28%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
Query: 151 ILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVI 210
I+ I I + + + +FT I+T E +K+ A G L ++ R+ +N LD +V+
Sbjct: 938 IVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVV 997
Query: 211 ALAYVTMGID---LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTM 267
+++ ++ GI + + LR RVLR L+ + GLK +V V +++ + +++I+T
Sbjct: 998 SVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1057
Query: 268 FSLSVFALMGLQIYMGVL 285
+FA +G+Q++ G L
Sbjct: 1058 LLQFMFACIGVQLFKGKL 1075
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 619 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 677
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 678 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 731
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/323 (22%), Positives = 141/323 (43%), Gaps = 76/323 (23%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 1231 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 1288
Query: 1270 K-------------WLALGF---------------QKYFTNAWCWLDFIIVMVSLINF-V 1300
K W F YF +AW D +IV+ S+++ +
Sbjct: 1289 KLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAI 1348
Query: 1301 AALCGAGGIQAFKTM-------------RTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1347
+ A Q +M R R +R ++ +SR +G+R ++ +++ ++
Sbjct: 1349 TEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQAL 1408
Query: 1348 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPM 1407
V L+ ++ + I+A++G+Q+F GK + +N TT EI N
Sbjct: 1409 PYVALLIVMLFFIYAVIGMQVF-GK----IALNDTT---EI---------------NRNN 1445
Query: 1408 NFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVG--RQPIRET-------NIYMYLYXX 1458
NF +A L LF+ AT + W IM + ++ +P T + + Y
Sbjct: 1446 NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFI 1505
Query: 1459 XXXXXXXXXTLNLFIGVIIDNFN 1481
+NLF+ VI+DNF+
Sbjct: 1506 SFYMLCAFLIINLFVAVIMDNFD 1528
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/177 (25%), Positives = 91/177 (51%), Gaps = 22/177 (12%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIFSSECLLKIFAL 1590
IV D F +I+ FI L+ +++ + Q +F + +L Y +++F IF+ E LKI
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGN 955
Query: 1591 RYHYFVEPWNLFDFVVVM----------------FSILSL-VLSDIIEKYFVSPTLLRVV 1633
+ F + L + ++ M F+IL L V+S + + + + + VV
Sbjct: 956 ADYVFTSIFTL-EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 1014
Query: 1634 RVAKVGRVLRLVKG---AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
++ +V RVLR ++ AKG++ ++ + +++ + NI ++ L+ F+FA G+ F
Sbjct: 1015 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF 1071
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 1382 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 1441
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 1442 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 1474
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 38.3 bits (85), Expect = 0.27
Identities = 20/75 (26%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 825 KALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLF-GK 883
KAL++ LR +L P+L ++++ + + M L ++ ++ +I I+A++G++LF GK
Sbjct: 234 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGK 293
Query: 884 NYVDYVDRFPDGDLP 898
+ ++ D+P
Sbjct: 294 MHKTCYNQEGIADVP 308
Score = 34.3 bits (75), Expect = 4.5
Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 1292
Query: 189 GFILQPFTYLRDAWNWLDFVVI 210
+P Y D WN DF+++
Sbjct: 1293 ---FKPKGYFSDPWNVFDFLIV 1311
>X65361-1|CAA46438.1| 245|Homo sapiens brain type II sodium channel
alpha-subunit (HBSC II) protein.
Length = 245
Score = 204 bits (499), Expect = 2e-51
Identities = 96/205 (46%), Positives = 142/205 (69%), Gaps = 8/205 (3%)
Query: 1714 QMSTSAGWDGVLDGIINE--EECDLPDNERGSP--GNCGSATIGITYLLSYLVISFLIVI 1769
Q++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++ISFL+V+
Sbjct: 1 QITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 60
Query: 1770 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPP 1829
NMYIAVILEN+S ATE+ E L++DD++M+YE+W++FDPD +Q+I + +LSDF D L+PP
Sbjct: 61 NMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPP 120
Query: 1830 LQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGN----PIEETGDLEVGRP 1885
L I KPNK ++I+MD+P+ GD + C+DIL A TK G I+ P
Sbjct: 121 LLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNP 180
Query: 1886 EEAGYEPVSSTLWRQREEYCARLIQ 1910
+ YEP+++TL R++EE A +IQ
Sbjct: 181 SKVSYEPITTTLKRKQEEVSAIIIQ 205
>AB209016-1|BAD92253.1| 840|Homo sapiens Voltage-dependent L-type
calcium channel alpha-1C subunit variant protein.
Length = 840
Score = 191 bits (466), Expect = 2e-47
Identities = 124/395 (31%), Positives = 211/395 (53%), Gaps = 21/395 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL+ +++ +T F ++ ILLSS++LA ED + H IL D +FT IF +E+
Sbjct: 451 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEI 509
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRP 1323
++K A G + N + LD ++V VSLI+F + I K +R LR LRP
Sbjct: 510 ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ---SSAINVVKILRVLRVLRP 566
Query: 1324 LRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTT 1383
LRA++R +G++ VV + AI +I N+++V + +FA +GVQLF GK + C D + T
Sbjct: 567 LRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQT 626
Query: 1384 LSH---EIIPDKNA----CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
+ I K+ ++ +WENS +FD+V A + LF V+TF+GW +++ +I
Sbjct: 627 EAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSI 686
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
DS + PI + + ++ +N+F+G +I F EQ ++ + E+
Sbjct: 687 DSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN 746
Query: 1497 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLD 1556
+ Q Y A+K +PL+ P+ + Q V+ +V F+ ++ + I LN + + +
Sbjct: 747 QRQCVEY-ALK----ARPLRRY-IPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 800
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR 1591
HY QS F ++ LNM+F +F+ E +LK+ A +
Sbjct: 801 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 835
Score = 101 bits (242), Expect = 3e-20
Identities = 71/257 (27%), Positives = 129/257 (50%), Gaps = 24/257 (9%)
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRY 1592
V F +++ + LN LT+ +HY Q + V D N + +F++E LLK+++L
Sbjct: 82 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 141
Query: 1593 H-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGI 1651
YFV +N FD VV IL +L +E +SP + V+R ++ R+ ++ + +
Sbjct: 142 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 198
Query: 1652 RTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVY----NFKTFVQ 1707
L+ +L S+ ++ ++ LLLFL + IF++ GM F K D++ F F Q
Sbjct: 199 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF---GGKFNFDEMQTRRSTFDNFPQ 255
Query: 1708 SMILLFQMSTSAGWDGVL-DGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFL 1766
S++ +FQ+ T W+ V+ DGI+ G P G + Y + +
Sbjct: 256 SLLTVFQILTGEDWNSVMYDGIM----------AYGGPSFPG--MLVCIYFIILFICGNY 303
Query: 1767 IVINMYIAVILENYSQA 1783
I++N+++A+ ++N + A
Sbjct: 304 ILLNVFLAIAVDNLADA 320
Score = 78.6 bits (185), Expect = 2e-13
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 31/305 (10%)
Query: 1198 SPFWQGWGTL-RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMD 1256
S +W+ W R K +++ F VI ++ L++L +A E + P+ L ++ +
Sbjct: 64 SRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNW--LTEVQDTAN 121
Query: 1257 RIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMR 1316
+ +F EML+K +LG Q YF + + D +V ++ + +R
Sbjct: 122 KALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLR 181
Query: 1317 TLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC 1376
+R LR + + +V +L+ ++ SI ++LL+ +F +IF+++G+QLF GK+
Sbjct: 182 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--N 239
Query: 1377 VDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAI 1436
D T S FD+ ++ L +FQ+ T + W +M D I
Sbjct: 240 FDEMQTRRS----------------------TFDNFPQSLLTVFQILTGEDWNSVMYDGI 277
Query: 1437 DSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEMFMT 1496
+ P + + +Y LN+F+ + +DN + + E
Sbjct: 278 MAYGGPSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEE 333
Query: 1497 EDQKK 1501
+++KK
Sbjct: 334 KERKK 338
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/121 (29%), Positives = 71/121 (58%), Gaps = 3/121 (2%)
Query: 168 STEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---LGNL 224
+ + +FT I+T E +K+ A G L ++ R+ +N LD +V++++ ++ GI + +
Sbjct: 496 NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVV 555
Query: 225 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGV 284
LR RVLR L+ + GLK +V V +++ + +++I+T +FA +G+Q++ G
Sbjct: 556 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGK 615
Query: 285 L 285
L
Sbjct: 616 L 616
Score = 60.9 bits (141), Expect = 5e-08
Identities = 34/118 (28%), Positives = 63/118 (53%), Gaps = 6/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L+ LR+FK+ + W +L+ L++ + ++ ++ +L +L + I IF+++GMQLFG +
Sbjct: 180 LRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF- 238
Query: 887 DYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLATV 943
F + R F +F S + VF++L GE W M+D ++ P L +
Sbjct: 239 ----NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 292
Score = 58.8 bits (136), Expect = 2e-07
Identities = 43/162 (26%), Positives = 86/162 (53%), Gaps = 12/162 (7%)
Query: 1532 IVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF-SAVLDYLNMIFIVIFSSECLLKIFA- 1589
IV D F +I+ FI L+ +++ + Q +F + +L + +F IF+ E +LK+ A
Sbjct: 457 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 516
Query: 1590 ---LRYHYFVEPW-NLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
L F + N+ D +VV S++S + + +++++RV +V R LR +
Sbjct: 517 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS------AINVVKILRVLRVLRPLRAI 570
Query: 1646 KGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
AKG++ ++ + +++ + NI ++ L+ F+FA G+ F
Sbjct: 571 NRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF 612
Score = 40.3 bits (90), Expect = 0.068
Identities = 16/60 (26%), Positives = 36/60 (60%)
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ LR R+LR K L +V +++ SV+++ +++L + +F+L+G+Q++ G
Sbjct: 177 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 236
>BC051374-1|AAH51374.1| 223|Homo sapiens SCN5A protein protein.
Length = 223
Score = 187 bits (455), Expect = 4e-46
Identities = 98/206 (47%), Positives = 123/206 (59%), Gaps = 8/206 (3%)
Query: 14 SLFRPFTRESLXXXXXXXXXXXXKQKELEKKRAEGEVRYXXXXXXXGPQPDATLEQGLPL 73
S FR FTRESL + ++ EG P+P L+ L
Sbjct: 11 SSFRRFTRESLAAIEKRMAEKQARGSTTLQESREG------LPEEEAPRPQLDLQASKKL 64
Query: 74 PVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRV 133
P + G+ P EL PLED+DPFY Q TF+V++KGK IFRFSATNAL++L PF+PIRR
Sbjct: 65 P-DLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRA 123
Query: 134 AIYILVHPLFSLFIITTILVNCILMIM-PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
A+ ILVH LF++ I+ TIL NC+ M P + E FT IYTFES VK++ARGF L
Sbjct: 124 AVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCL 183
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMG 218
FT+LRD WNWLDF VI +A +G
Sbjct: 184 HAFTFLRDPWNWLDFSVIIMAASVLG 209
Score = 35.5 bits (78), Expect = 1.9
Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 4/46 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVS 1295
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++
Sbjct: 159 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA 204
>AJ310892-1|CAC84535.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 185 bits (451), Expect = 1e-45
Identities = 90/148 (60%), Positives = 115/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AYV+ I LGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/137 (34%), Positives = 82/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ +V+ G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YVSENIKLGNL 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTI---SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 50.8 bits (116), Expect = 5e-05
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + +S E
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS-------ENIK 64
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 65 LGN--LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310889-1|CAC84532.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 185 bits (451), Expect = 1e-45
Identities = 90/148 (60%), Positives = 115/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AYV+ I LGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/137 (34%), Positives = 82/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ +V+ G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YVSENIKLGNL 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTI---SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 50.8 bits (116), Expect = 5e-05
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + +S E
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS-------ENIK 64
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 65 LGN--LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310888-1|CAC84531.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 185 bits (451), Expect = 1e-45
Identities = 90/148 (60%), Positives = 115/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AYV+ I LGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/137 (34%), Positives = 82/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ +V+ G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YVSENIKLGNL 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTI---SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 50.8 bits (116), Expect = 5e-05
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + +S E
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS-------ENIK 64
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 65 LGN--LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310887-1|CAC84530.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 185 bits (451), Expect = 1e-45
Identities = 90/148 (60%), Positives = 115/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AYV+ I LGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/137 (34%), Positives = 82/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ +V+ G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YVSENIKLGNL 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTI---SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 50.8 bits (116), Expect = 5e-05
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + +S E
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS-------ENIK 64
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 65 LGN--LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310886-1|CAC84529.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 185 bits (451), Expect = 1e-45
Identities = 90/148 (60%), Positives = 115/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AYV+ I LGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
L+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/137 (34%), Positives = 82/137 (59%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ +V+ G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YVSENIKLGNL 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTI---SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 50.8 bits (116), Expect = 5e-05
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + +S E
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS-------ENIK 64
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 65 LGN--LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310891-1|CAC84534.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 182 bits (443), Expect = 1e-44
Identities = 88/148 (59%), Positives = 114/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AY T +DLGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ALRTFRVLRALKT++++ GLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 51.6 bits (118), Expect = 3e-05
Identities = 34/124 (27%), Positives = 61/124 (49%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + + F
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EF 62
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
V + +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 63 VDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ310890-1|CAC84533.1| 156|Homo sapiens Nav1.5 protein.
Length = 156
Score = 182 bits (443), Expect = 1e-44
Identities = 88/148 (59%), Positives = 114/148 (77%), Gaps = 3/148 (2%)
Query: 164 PTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN 223
P + E FT IYTFES VK++ARGF L FT+LRD WNWLDF VI +AY T +DLGN
Sbjct: 8 PWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN 67
Query: 224 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 283
++ALRTFRVLRALKT++++ GLKTIVGA+I+SVK L DV++LT+F LSVFAL+GLQ++MG
Sbjct: 68 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 127
Query: 284 VLTQKCVKVFPE-DGSWGNLTDEN--WE 308
L KCV+ F +G+ G++ + WE
Sbjct: 128 NLRHKCVRNFTALNGTNGSVEADGLVWE 155
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/137 (33%), Positives = 80/137 (58%), Gaps = 12/137 (8%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKY-FT---NAWCWLDFIIVMVSLINFVAALCGAGGI 1309
Y++ FT I+ E L+K LA GF + FT + W WLDF +++++ + G +
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA---YTTEFVDLGNV 68
Query: 1310 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLF 1369
A +T R LRAL+ + +S G++ +V AL+Q++ + +V+++ + +FA++G+QLF
Sbjct: 69 SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 125
Query: 1370 AGKY-FKCVDMNHTTLS 1385
G KCV N T L+
Sbjct: 126 MGNLRHKCV-RNFTALN 141
Score = 51.6 bits (118), Expect = 3e-05
Identities = 34/124 (27%), Positives = 61/124 (49%), Gaps = 14/124 (11%)
Query: 1570 YLNMIFIVIFSSECLLKIFALRY--HYFV---EPWNLFDFVVVMFSILSLVLSDIIEKYF 1624
Y+ F I++ E L+KI A + H F +PWN DF V++ + + F
Sbjct: 12 YVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTT---------EF 62
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
V + +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 63 VDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGL 122
Query: 1685 SFFM 1688
FM
Sbjct: 123 QLFM 126
>AJ277394-1|CAC03586.1| 121|Homo sapiens voltage-gated sodium
channel protein.
Length = 121
Score = 178 bits (433), Expect = 2e-43
Identities = 81/119 (68%), Positives = 103/119 (86%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES +K++ARGF L+ FT+LRD WNWLDF VI +AYVT + LGN++A
Sbjct: 2 KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSA 61
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 62 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL 120
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A +T
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSALRT 64
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 65 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 118
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/119 (30%), Positives = 62/119 (52%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKI----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI F L F+ +PWN DF V+ V++ + E FVS
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGN 58
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 59 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 117
>AJ276140-1|CAC03583.1| 121|Homo sapiens SCN3A protein.
Length = 121
Score = 178 bits (433), Expect = 2e-43
Identities = 81/119 (68%), Positives = 103/119 (86%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES +K++ARGF L+ FT+LRD WNWLDF VI +AYVT + LGN++A
Sbjct: 2 KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSA 61
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 62 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL 120
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A +T
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSALRT 64
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 65 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 118
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/119 (30%), Positives = 62/119 (52%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKI----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI F L F+ +PWN DF V+ V++ + E FVS
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGN 58
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 59 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 117
>AJ276139-1|CAC03582.1| 121|Homo sapiens SCN3A protein.
Length = 121
Score = 178 bits (433), Expect = 2e-43
Identities = 81/119 (68%), Positives = 103/119 (86%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES +K++ARGF L+ FT+LRD WNWLDF VI +AYVT + LGN++A
Sbjct: 2 KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSA 61
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVL 285
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GLQ++MG L
Sbjct: 62 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL 120
Score = 72.9 bits (171), Expect = 1e-11
Identities = 39/117 (33%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E LIK LA GF + + W WLDF +++++ +V G + A +T
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA---YVTEFVSLGNVSALRT 64
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+QLF G
Sbjct: 65 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 118
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/119 (30%), Positives = 62/119 (52%), Gaps = 14/119 (11%)
Query: 1575 FIVIFSSECLLKI----FALRYHYFV-EPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI F L F+ +PWN DF V+ V++ + E FVS
Sbjct: 8 FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVI-------VMAYVTE--FVSLGN 58
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 59 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 117
>AF100774-1|AAC77460.1| 980|Homo sapiens voltage-dependent P/Q type
calcium channel alpha 1A subunit protein.
Length = 980
Score = 175 bits (426), Expect = 1e-42
Identities = 113/392 (28%), Positives = 202/392 (51%), Gaps = 28/392 (7%)
Query: 1511 SKKPL-KAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLD 1569
S KPL + +P+ + Q +++ V F+ IM I LN + + + Y S + L
Sbjct: 26 SAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALR 85
Query: 1570 YLNMIFIVIFSSECLLKIFALRY-HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPT 1628
N++F +FS EC+LK+ A +YF + WN+FDFV V+ SI +++++ F++ +
Sbjct: 86 VFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNN-FINLS 144
Query: 1629 LLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF- 1687
LR+ R A R+++L++ IR LL+ S AL +CLL+ ++ FI+AI GM F
Sbjct: 145 FLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 201
Query: 1688 ---MHVKDKGGLDDVY------NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPD 1738
+ V+D+ +D + NF+TF Q+++LLF+ +T W ++ ++ + CD
Sbjct: 202 NIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD--K 259
Query: 1739 NERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1798
N CG+ Y +S++ + +++N+++AVI++N+ T D L D
Sbjct: 260 NSGILTRECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDE 317
Query: 1799 YYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDMM 1853
Y +W +DP I Y + L V+ PPL + K P++ +++ MD+P+ + +
Sbjct: 318 YVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTV 377
Query: 1854 FCVDILDALTK---DFFARKGNPIEETGDLEV 1882
L AL + D KG ++ D E+
Sbjct: 378 HFNSTLMALIRTALDIKIAKGGADKQQMDAEL 409
Score = 82.2 bits (194), Expect = 2e-14
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 1206 TLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFI 1265
+ + + ++ + + FE ++ MI L+++ L ++ ++ L + +FT +F +
Sbjct: 40 SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK--FYGASVAYENALRVFNIVFTSLFSL 97
Query: 1266 EMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLR 1325
E ++K +A G YF +AW DF+ V+ S+ + + G I +R RA R ++
Sbjct: 98 ECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFIN-LSFLRLFRAARLIK 156
Query: 1326 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLS 1385
+ + +R+++ VQ+ ++ V L+ + + I+AI+G+Q+F D + S
Sbjct: 157 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDED----S 212
Query: 1386 HEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQP 1445
E D+ T N NF +A + LF+ AT + W IM + + +
Sbjct: 213 DE---DEFQITEHN--------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNS 261
Query: 1446 ---IRET-NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNF 1480
RE N + Y Y LNLF+ VI+DNF
Sbjct: 262 GILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 300
Score = 64.5 bits (150), Expect = 4e-09
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 138 LVHPLFSLFIITTILVNCILMIMP---TTPTVEST----EVIFTGIYTFESAVKVMARGF 190
+V P F I+ I +N I+++M + E+ ++FT +++ E +KVMA G
Sbjct: 49 VVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGI 108
Query: 191 ILQPFTYLRDAWNWLDFVVIA-----LAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGL 245
+ Y RDAWN DFV + + G + NL+ LR FR R +K + +
Sbjct: 109 L----NYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTI 164
Query: 246 KTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
+ ++ ++S K L V +L ++A++G+Q++
Sbjct: 165 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 200
Score = 52.4 bits (120), Expect = 2e-05
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
R+ KL + T+ +L+ ++ AL + ++ ++ FI+A++GMQ+FG +D D
Sbjct: 153 RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 212
Query: 894 DGD----LPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
D D NF F + M++FR GE W M C+
Sbjct: 213 DEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 252
>AJ310883-1|CAC84551.1| 115|Homo sapiens Nav1.7 protein.
Length = 115
Score = 167 bits (407), Expect = 3e-40
Identities = 77/112 (68%), Positives = 97/112 (86%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDFVVI AY+T ++LGN++A
Sbjct: 4 KNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSA 63
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GL
Sbjct: 64 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
Score = 64.5 bits (150), Expect = 4e-09
Identities = 33/112 (29%), Positives = 65/112 (58%), Gaps = 10/112 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K LA GF + + W WLDF++++ + ++ G + A +T
Sbjct: 10 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSALRT 66
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGV 1366
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+
Sbjct: 67 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 14/115 (12%)
Query: 1575 FIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DFVV++F+ L+ FV+
Sbjct: 10 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGN 60
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 61 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
>AJ310882-1|CAC84550.1| 115|Homo sapiens Nav1.7 protein.
Length = 115
Score = 167 bits (407), Expect = 3e-40
Identities = 77/112 (68%), Positives = 97/112 (86%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA 226
++ E FTGIYTFES VK++ARGF + FT+LRD WNWLDFVVI AY+T ++LGN++A
Sbjct: 4 KNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSA 63
Query: 227 LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
LRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV+ILT+F LSVFAL+GL
Sbjct: 64 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
Score = 64.5 bits (150), Expect = 4e-09
Identities = 33/112 (29%), Positives = 65/112 (58%), Gaps = 10/112 (8%)
Query: 1259 FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKT 1314
FT I+ E L+K LA GF + + W WLDF++++ + ++ G + A +T
Sbjct: 10 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA---YLTEFVNLGNVSALRT 66
Query: 1315 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGV 1366
R LRAL+ + S + G++ +V AL+Q++ + +V+++ + +FA++G+
Sbjct: 67 FRVLRALKTI---SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 14/115 (12%)
Query: 1575 FIVIFSSECLLKIFAL-----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTL 1629
F I++ E L+KI A + + +PWN DFVV++F+ L+ FV+
Sbjct: 10 FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---------EFVNLGN 60
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+ +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+
Sbjct: 61 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 115
>U93305-4|AAB92359.1| 644|Homo sapiens calcium channel alpha-1
subunit protein.
Length = 644
Score = 165 bits (400), Expect = 2e-39
Identities = 92/302 (30%), Positives = 171/302 (56%), Gaps = 15/302 (4%)
Query: 1557 HYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLV 1615
HY+Q+ F+ +D LNM+F +F+ +LKI A + HYF + WN FD ++V+ SI+ +
Sbjct: 1 HYEQTAPFNYAMDILNMVFTGLFTIVMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIA 60
Query: 1616 LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
++++ S + R+ +V R+++L+ +GIRTLL+ S AL + LL+ ++
Sbjct: 61 VTEVNSSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMI 120
Query: 1676 MFIFAIFGMSFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEE 1733
FI+A+ GM F + ++D ++ NF+TF Q+++LLF+ +T W ++ +
Sbjct: 121 FFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNR 180
Query: 1734 CDLPDNERGSPG---NCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEG 1790
CD P+++ G PG CGS I Y +S+ ++ ++IN+++AVI++N+ T D
Sbjct: 181 CD-PESDFG-PGEEFTCGS-NFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRD-WSI 236
Query: 1791 LTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDI 1845
L D + IW +DP I++ + L ++PPL K P++ ++++M++
Sbjct: 237 LGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNM 296
Query: 1846 PI 1847
P+
Sbjct: 297 PL 298
Score = 63.3 bits (147), Expect = 8e-09
Identities = 56/237 (23%), Positives = 108/237 (45%), Gaps = 33/237 (13%)
Query: 1255 MDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQ---A 1311
++ +FT +F I M++K +A + YFT+AW D +IV+ S+++ + +
Sbjct: 15 LNMVFTGLFTIVMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNSSEDSSRIS 74
Query: 1312 FKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
R R +R ++ +S+ +G+R ++ +++ ++ V L+ + + I+A++G+Q+F G
Sbjct: 75 ITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-G 133
Query: 1372 KYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQI 1431
K L++ T N NF +A L LF+ AT + W +I
Sbjct: 134 K----------------------VALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEI 171
Query: 1432 MNDAIDSREVGRQ----PIRETNI---YMYLYXXXXXXXXXXXTLNLFIGVIIDNFN 1481
M ++ + P E + Y +NLF+ VI+DNF+
Sbjct: 172 MLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFD 228
Score = 55.2 bits (127), Expect = 2e-06
Identities = 34/136 (25%), Positives = 69/136 (50%), Gaps = 13/136 (9%)
Query: 161 PTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID 220
P ++ ++FTG++T +K++A +P Y DAWN D +++ + V + +
Sbjct: 7 PFNYAMDILNMVFTGLFTIVMVLKIIA----FKPKHYFTDAWNTFDALIVVGSIVDIAVT 62
Query: 221 LGN---------LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLS 271
N + R FRV+R +K ++ G++T++ I+S + L V +L
Sbjct: 63 EVNSSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFF 122
Query: 272 VFALMGLQIYMGVLTQ 287
++A++G+Q++ V Q
Sbjct: 123 IYAVIGMQMFGKVALQ 138
Score = 41.9 bits (94), Expect = 0.022
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 800 FITLCIVVNTLFMALDHHNMDKDMDKA----LKSGNYLRVFKLAKSWPTLNLLISIMGRT 855
F L +V + + +A+ N +D + + +R+ KL + L+ ++
Sbjct: 47 FDALIVVGSIVDIAVTEVNSSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKS 106
Query: 856 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRV 915
AL + ++ +I FI+AV+GMQ+FGK + + + NF F + +++FR
Sbjct: 107 FQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNN----NFQTFPQAVLLLFRC 162
Query: 916 LCGE-WIESM 924
GE W E M
Sbjct: 163 ATGEAWQEIM 172
>AY141972-1|AAN10255.1| 1738|Homo sapiens putative 4 repeat
voltage-gated ion channel protein.
Length = 1738
Score = 165 bits (400), Expect = 2e-39
Identities = 169/646 (26%), Positives = 289/646 (44%), Gaps = 59/646 (9%)
Query: 1218 TYFETAVITMILLSSLALALEDV--HLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALG 1275
TY + +I + + S +++ E + H P LQ Y +F + IE+ +K +A G
Sbjct: 886 TYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEY----VFVIFMSIELNLKIMADG 941
Query: 1276 FQKYFTNAWCWLDF------IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
+FT DF I +VSLI + + LR LRPLR
Sbjct: 942 L--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKL 999
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN--------- 1380
+ MR VV L IF V ++ L L+FA GVQLFAGK KC D N
Sbjct: 1000 VPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG 1059
Query: 1381 --------HTTLSHEIIP-DKNACTLENYTWENSP-MNFDHVGKAYLCLFQVATFKGWIQ 1430
L+ ++ P +K W N NFD+VG A L LF+V + KGW++
Sbjct: 1060 IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVE 1119
Query: 1431 IMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGS 1490
+ D I R VG PI I+++++ L LF+GV+I NFNE K A
Sbjct: 1120 V-RDVIIHR-VG--PIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGTA--- 1166
Query: 1491 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLN 1549
+T DQ+++ + ++ +PL PRP +A +++I F I L +
Sbjct: 1167 ---LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQ 1223
Query: 1550 MLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-NLFDFVVVM 1608
+ +++ + + + L ++++F IF E +KI A+ F + N +D +V
Sbjct: 1224 SVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1282
Query: 1609 FSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNI 1668
++ +VL + + V+ V R + ++ LL + +S+ F I
Sbjct: 1283 LGVVWVVLHFALLNAYTYMMGACVI----VFRFFSICGKHVTLKMLLLTVVVSMYKSFFI 1338
Query: 1669 CLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGI 1728
+ +FL++ +A G+ F VK ++ NF + +++ +LF++ T W+ ++
Sbjct: 1339 IVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1398
Query: 1729 INEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYS--QATED 1786
+ + PD +CG+ + Y S+ VI I++N+ +A+I+EN+S +TE+
Sbjct: 1399 MVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1458
Query: 1787 VQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQI 1832
Q L+ +D + IW D I ++ L +L L++
Sbjct: 1459 DQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV 1503
Score = 107 bits (258), Expect = 3e-22
Identities = 139/589 (23%), Positives = 254/589 (43%), Gaps = 84/589 (14%)
Query: 1244 HRPILQDILYYMDRIFTVIFFIEML----IKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P LQ + + +D + ++ EM+ I+ + G Y + WC D +V ++
Sbjct: 63 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSL 122
Query: 1300 VAALCGAGGIQ-------AFKTMRTLRALRPLRAMSRMQGMRV-VVNALVQAIPSIFNVL 1351
V + I + R L +R R R + R + N L ++ I++V
Sbjct: 123 VLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 182
Query: 1352 LVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT-----TLSHEIIPDKNA------------ 1394
+ L F L++ I+GVQ+F + CV +N T T + IPD +
Sbjct: 183 IFLLFFLLLYGILGVQMFGTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPP 241
Query: 1395 ---CT-LENYTWENSPMN---FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR 1447
C LE+ + F+ +G + +++ A+ +GW+ +M AIDS R
Sbjct: 242 GFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRS--- 298
Query: 1448 ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNE---QKKKAGGSLEMFMTEDQKKYYN 1504
Y Y N+FI VII+ F E Q ++ GS + + ++
Sbjct: 299 ------YFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFH 352
Query: 1505 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
G + + +P+ R A + +++ F M I+ + ++++ ++Y+ E F
Sbjct: 353 EDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYK-GENF 411
Query: 1565 SAVLD--YL-NMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDII 1620
D YL + F V+F E LLKI+ L + Y + F+ ++V+ + L V D+
Sbjct: 412 RRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-VYPDLY 470
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
F +LRVVR+ K+ L + +F L +L L +VM +
Sbjct: 471 HSQFTYFQVLRVVRLIKISPAL------EDFVYKIFGPGKKLGSLVVFTASLLIVM---S 521
Query: 1681 IFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
+ F V++ LD F TF ++ + +FQ+ T GW V+D +N
Sbjct: 522 AISLQMFCFVEE---LD---RFTTFPRAFMSMFQILTQEGWVDVMDQTLN---------- 565
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ G+ + + I Y + Y + + LI++++++AVIL+N + ED+++
Sbjct: 566 --AVGHMWAPVVAI-YFILYHLFATLILLSLFVAVILDNL-ELDEDLKK 610
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/165 (27%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 138 LVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYTFESAVKVMARGF 190
LV L + II TI +CI M+ + PT++ E +F + E +K+MA G
Sbjct: 884 LVTYLDWVMIIVTIC-SCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA------LRTFRVLRALKTVAIVPG 244
P +RD +D + ++ + + N+ A L R LR L+ +VP
Sbjct: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
Query: 245 LKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
++ +V + K + V IL + + VFA G+Q++ G L KC
Sbjct: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA-KC 1046
Score = 50.8 bits (116), Expect = 5e-05
Identities = 54/291 (18%), Positives = 121/291 (41%), Gaps = 25/291 (8%)
Query: 139 VHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
VH L + I +++ C+ M P + + + +YT E K+ RG +
Sbjct: 38 VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVK 97
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA----ALRTFRVLRALKTVAIVPGLK-- 246
+Y++D W D ++ +V++ + + +A + + +LR + + ++ +
Sbjct: 98 GDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIY 157
Query: 247 --------TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV--KVFPED 296
I + S + + V I +F L ++ ++G+Q++ G T CV P +
Sbjct: 158 FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGN 216
Query: 297 GSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
+W +L + + E + G + G + E GY G + Y +
Sbjct: 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQLFFVVIIFLGSFYLVNLILAIVAMSY 407
GW FL + + W + + +F+ +IF ++ + N+ +A++ ++
Sbjct: 277 ASQEGWVFLMYRAIDSFPRWRSYF--YFITLIFFLAWLVKNVFIAVIIETF 325
Score = 40.3 bits (90), Expect = 0.068
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRT 229
EV FT ++ E+ +K+ GF Y+ + + + +++ + + DL + +
Sbjct: 422 EVAFTVLFDLEALLKIWCLGFT----GYISSSLHKFELLLVIGTTLHVYPDLYH-SQFTY 476
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
F+VLR ++ + I P L+ V + K L +++ T L V + + LQ++ V
Sbjct: 477 FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Query: 290 VKVFPED--GSWGNLTDENW 307
FP + LT E W
Sbjct: 537 FTTFPRAFMSMFQILTQEGW 556
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/110 (20%), Positives = 53/110 (48%), Gaps = 1/110 (0%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++ ++ F +++M+ + + A + D Y + FTV+F +E L+K
Sbjct: 379 KMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIW 438
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
LGF Y +++ + ++V+ + ++ L + F+ +R +R ++
Sbjct: 439 CLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHS-QFTYFQVLRVVRLIK 487
Score = 33.5 bits (73), Expect = 7.8
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 126 PFNPIRRVAIY-ILVHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYT 178
P N R +Y I HP F I +L +L+ + P T + + V+FT I+
Sbjct: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFV 1253
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKT 238
E +K++A + P + + N D +V +L V + + + A L + + +
Sbjct: 1254 LEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVL---HFALLNAYTYM--MGA 1304
Query: 239 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
IV +I G + ++K L ++++M+ S F ++G+
Sbjct: 1305 CVIVFRFFSICGKHV-TLKMLLLTVVVSMYK-SFFIIVGM 1342
>AL356778-1|CAI16648.1| 1738|Homo sapiens voltage gated channel like 1
protein.
Length = 1738
Score = 165 bits (400), Expect = 2e-39
Identities = 169/646 (26%), Positives = 289/646 (44%), Gaps = 59/646 (9%)
Query: 1218 TYFETAVITMILLSSLALALEDV--HLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALG 1275
TY + +I + + S +++ E + H P LQ Y +F + IE+ +K +A G
Sbjct: 886 TYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEY----VFVIFMSIELNLKIMADG 941
Query: 1276 FQKYFTNAWCWLDF------IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
+FT DF I +VSLI + + LR LRPLR
Sbjct: 942 L--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKL 999
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN--------- 1380
+ MR VV L IF V ++ L L+FA GVQLFAGK KC D N
Sbjct: 1000 VPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG 1059
Query: 1381 --------HTTLSHEIIP-DKNACTLENYTWENSP-MNFDHVGKAYLCLFQVATFKGWIQ 1430
L+ ++ P +K W N NFD+VG A L LF+V + KGW++
Sbjct: 1060 IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVE 1119
Query: 1431 IMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGS 1490
+ D I R VG PI I+++++ L LF+GV+I NFNE K A
Sbjct: 1120 V-RDVIIHR-VG--PIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGTA--- 1166
Query: 1491 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLN 1549
+T DQ+++ + ++ +PL PRP +A +++I F I L +
Sbjct: 1167 ---LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQ 1223
Query: 1550 MLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-NLFDFVVVM 1608
+ +++ + + + L ++++F IF E +KI A+ F + N +D +V
Sbjct: 1224 SVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1282
Query: 1609 FSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNI 1668
++ +VL + + V+ V R + ++ LL + +S+ F I
Sbjct: 1283 LGVVWVVLHFALLNAYTYMMGACVI----VFRFFSICGKHVTLKMLLLTVVVSMYKSFFI 1338
Query: 1669 CLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGI 1728
+ +FL++ +A G+ F VK ++ NF + +++ +LF++ T W+ ++
Sbjct: 1339 IVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1398
Query: 1729 INEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYS--QATED 1786
+ + PD +CG+ + Y S+ VI I++N+ +A+I+EN+S +TE+
Sbjct: 1399 MVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1458
Query: 1787 VQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQI 1832
Q L+ +D + IW D I ++ L +L L++
Sbjct: 1459 DQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV 1503
Score = 107 bits (258), Expect = 3e-22
Identities = 139/589 (23%), Positives = 254/589 (43%), Gaps = 84/589 (14%)
Query: 1244 HRPILQDILYYMDRIFTVIFFIEML----IKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P LQ + + +D + ++ EM+ I+ + G Y + WC D +V ++
Sbjct: 63 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSL 122
Query: 1300 VAALCGAGGIQ-------AFKTMRTLRALRPLRAMSRMQGMRV-VVNALVQAIPSIFNVL 1351
V + I + R L +R R R + R + N L ++ I++V
Sbjct: 123 VLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 182
Query: 1352 LVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT-----TLSHEIIPDKNA------------ 1394
+ L F L++ I+GVQ+F + CV +N T T + IPD +
Sbjct: 183 IFLLFFLLLYGILGVQMFGTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPP 241
Query: 1395 ---CT-LENYTWENSPMN---FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR 1447
C LE+ + F+ +G + +++ A+ +GW+ +M AIDS R
Sbjct: 242 GFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRS--- 298
Query: 1448 ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNE---QKKKAGGSLEMFMTEDQKKYYN 1504
Y Y N+FI VII+ F E Q ++ GS + + ++
Sbjct: 299 ------YFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFH 352
Query: 1505 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
G + + +P+ R A + +++ F M I+ + ++++ ++Y+ E F
Sbjct: 353 EDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYK-GENF 411
Query: 1565 SAVLD--YL-NMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDII 1620
D YL + F V+F E LLKI+ L + Y + F+ ++V+ + L V D+
Sbjct: 412 RRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-VYPDLY 470
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
F +LRVVR+ K+ L + +F L +L L +VM +
Sbjct: 471 HSQFTYFQVLRVVRLIKISPAL------EDFVYKIFGPGKKLGSLVVFTASLLIVM---S 521
Query: 1681 IFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
+ F V++ LD F TF ++ + +FQ+ T GW V+D +N
Sbjct: 522 AISLQMFCFVEE---LD---RFTTFPRAFMSMFQILTQEGWVDVMDQTLN---------- 565
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ G+ + + I Y + Y + + LI++++++AVIL+N + ED+++
Sbjct: 566 --AVGHMWAPVVAI-YFILYHLFATLILLSLFVAVILDNL-ELDEDLKK 610
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/165 (27%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 138 LVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYTFESAVKVMARGF 190
LV L + II TI +CI M+ + PT++ E +F + E +K+MA G
Sbjct: 884 LVTYLDWVMIIVTIC-SCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA------LRTFRVLRALKTVAIVPG 244
P +RD +D + ++ + + N+ A L R LR L+ +VP
Sbjct: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
Query: 245 LKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
++ +V + K + V IL + + VFA G+Q++ G L KC
Sbjct: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA-KC 1046
Score = 50.8 bits (116), Expect = 5e-05
Identities = 54/291 (18%), Positives = 121/291 (41%), Gaps = 25/291 (8%)
Query: 139 VHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
VH L + I +++ C+ M P + + + +YT E K+ RG +
Sbjct: 38 VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVK 97
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA----ALRTFRVLRALKTVAIVPGLK-- 246
+Y++D W D ++ +V++ + + +A + + +LR + + ++ +
Sbjct: 98 GDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIY 157
Query: 247 --------TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV--KVFPED 296
I + S + + V I +F L ++ ++G+Q++ G T CV P +
Sbjct: 158 FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGN 216
Query: 297 GSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
+W +L + + E + G + G + E GY G + Y +
Sbjct: 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQLFFVVIIFLGSFYLVNLILAIVAMSY 407
GW FL + + W + + +F+ +IF ++ + N+ +A++ ++
Sbjct: 277 ASQEGWVFLMYRAIDSFPRWRSYF--YFITLIFFLAWLVKNVFIAVIIETF 325
Score = 40.3 bits (90), Expect = 0.068
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRT 229
EV FT ++ E+ +K+ GF Y+ + + + +++ + + DL + +
Sbjct: 422 EVAFTVLFDLEALLKIWCLGFT----GYISSSLHKFELLLVIGTTLHVYPDLYH-SQFTY 476
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
F+VLR ++ + I P L+ V + K L +++ T L V + + LQ++ V
Sbjct: 477 FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Query: 290 VKVFPED--GSWGNLTDENW 307
FP + LT E W
Sbjct: 537 FTTFPRAFMSMFQILTQEGW 556
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/110 (20%), Positives = 53/110 (48%), Gaps = 1/110 (0%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++ ++ F +++M+ + + A + D Y + FTV+F +E L+K
Sbjct: 379 KMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIW 438
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
LGF Y +++ + ++V+ + ++ L + F+ +R +R ++
Sbjct: 439 CLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHS-QFTYFQVLRVVRLIK 487
Score = 33.5 bits (73), Expect = 7.8
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 126 PFNPIRRVAIY-ILVHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYT 178
P N R +Y I HP F I +L +L+ + P T + + V+FT I+
Sbjct: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFV 1253
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKT 238
E +K++A + P + + N D +V +L V + + + A L + + +
Sbjct: 1254 LEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVL---HFALLNAYTYM--MGA 1304
Query: 239 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
IV +I G + ++K L ++++M+ S F ++G+
Sbjct: 1305 CVIVFRFFSICGKHV-TLKMLLLTVVVSMYK-SFFIIVGM 1342
>AL354891-1|CAH73919.1| 1738|Homo sapiens voltage gated channel like 1
protein.
Length = 1738
Score = 165 bits (400), Expect = 2e-39
Identities = 169/646 (26%), Positives = 289/646 (44%), Gaps = 59/646 (9%)
Query: 1218 TYFETAVITMILLSSLALALEDV--HLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALG 1275
TY + +I + + S +++ E + H P LQ Y +F + IE+ +K +A G
Sbjct: 886 TYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEY----VFVIFMSIELNLKIMADG 941
Query: 1276 FQKYFTNAWCWLDF------IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
+FT DF I +VSLI + + LR LRPLR
Sbjct: 942 L--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKL 999
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN--------- 1380
+ MR VV L IF V ++ L L+FA GVQLFAGK KC D N
Sbjct: 1000 VPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG 1059
Query: 1381 --------HTTLSHEIIP-DKNACTLENYTWENSP-MNFDHVGKAYLCLFQVATFKGWIQ 1430
L+ ++ P +K W N NFD+VG A L LF+V + KGW++
Sbjct: 1060 IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVE 1119
Query: 1431 IMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGS 1490
+ D I R VG PI I+++++ L LF+GV+I NFNE K A
Sbjct: 1120 V-RDVIIHR-VG--PIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGTA--- 1166
Query: 1491 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLN 1549
+T DQ+++ + ++ +PL PRP +A +++I F I L +
Sbjct: 1167 ---LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQ 1223
Query: 1550 MLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-NLFDFVVVM 1608
+ +++ + + + L ++++F IF E +KI A+ F + N +D +V
Sbjct: 1224 SVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1282
Query: 1609 FSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNI 1668
++ +VL + + V+ V R + ++ LL + +S+ F I
Sbjct: 1283 LGVVWVVLHFALLNAYTYMMGACVI----VFRFFSICGKHVTLKMLLLTVVVSMYKSFFI 1338
Query: 1669 CLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGI 1728
+ +FL++ +A G+ F VK ++ NF + +++ +LF++ T W+ ++
Sbjct: 1339 IVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1398
Query: 1729 INEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYS--QATED 1786
+ + PD +CG+ + Y S+ VI I++N+ +A+I+EN+S +TE+
Sbjct: 1399 MVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1458
Query: 1787 VQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQI 1832
Q L+ +D + IW D I ++ L +L L++
Sbjct: 1459 DQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV 1503
Score = 107 bits (258), Expect = 3e-22
Identities = 139/589 (23%), Positives = 254/589 (43%), Gaps = 84/589 (14%)
Query: 1244 HRPILQDILYYMDRIFTVIFFIEML----IKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P LQ + + +D + ++ EM+ I+ + G Y + WC D +V ++
Sbjct: 63 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSL 122
Query: 1300 VAALCGAGGIQ-------AFKTMRTLRALRPLRAMSRMQGMRV-VVNALVQAIPSIFNVL 1351
V + I + R L +R R R + R + N L ++ I++V
Sbjct: 123 VLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 182
Query: 1352 LVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT-----TLSHEIIPDKNA------------ 1394
+ L F L++ I+GVQ+F + CV +N T T + IPD +
Sbjct: 183 IFLLFFLLLYGILGVQMFGTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPP 241
Query: 1395 ---CT-LENYTWENSPMN---FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR 1447
C LE+ + F+ +G + +++ A+ +GW+ +M AIDS R
Sbjct: 242 GFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRS--- 298
Query: 1448 ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNE---QKKKAGGSLEMFMTEDQKKYYN 1504
Y Y N+FI VII+ F E Q ++ GS + + ++
Sbjct: 299 ------YFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFH 352
Query: 1505 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
G + + +P+ R A + +++ F M I+ + ++++ ++Y+ E F
Sbjct: 353 EDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYK-GENF 411
Query: 1565 SAVLD--YL-NMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDII 1620
D YL + F V+F E LLKI+ L + Y + F+ ++V+ + L V D+
Sbjct: 412 RRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-VYPDLY 470
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
F +LRVVR+ K+ L + +F L +L L +VM +
Sbjct: 471 HSQFTYFQVLRVVRLIKISPAL------EDFVYKIFGPGKKLGSLVVFTASLLIVM---S 521
Query: 1681 IFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
+ F V++ LD F TF ++ + +FQ+ T GW V+D +N
Sbjct: 522 AISLQMFCFVEE---LD---RFTTFPRAFMSMFQILTQEGWVDVMDQTLN---------- 565
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ G+ + + I Y + Y + + LI++++++AVIL+N + ED+++
Sbjct: 566 --AVGHMWAPVVAI-YFILYHLFATLILLSLFVAVILDNL-ELDEDLKK 610
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/165 (27%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 138 LVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYTFESAVKVMARGF 190
LV L + II TI +CI M+ + PT++ E +F + E +K+MA G
Sbjct: 884 LVTYLDWVMIIVTIC-SCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA------LRTFRVLRALKTVAIVPG 244
P +RD +D + ++ + + N+ A L R LR L+ +VP
Sbjct: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
Query: 245 LKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
++ +V + K + V IL + + VFA G+Q++ G L KC
Sbjct: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA-KC 1046
Score = 50.8 bits (116), Expect = 5e-05
Identities = 54/291 (18%), Positives = 121/291 (41%), Gaps = 25/291 (8%)
Query: 139 VHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
VH L + I +++ C+ M P + + + +YT E K+ RG +
Sbjct: 38 VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVK 97
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA----ALRTFRVLRALKTVAIVPGLK-- 246
+Y++D W D ++ +V++ + + +A + + +LR + + ++ +
Sbjct: 98 GDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIY 157
Query: 247 --------TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV--KVFPED 296
I + S + + V I +F L ++ ++G+Q++ G T CV P +
Sbjct: 158 FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGN 216
Query: 297 GSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
+W +L + + E + G + G + E GY G + Y +
Sbjct: 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQLFFVVIIFLGSFYLVNLILAIVAMSY 407
GW FL + + W + + +F+ +IF ++ + N+ +A++ ++
Sbjct: 277 ASQEGWVFLMYRAIDSFPRWRSYF--YFITLIFFLAWLVKNVFIAVIIETF 325
Score = 40.3 bits (90), Expect = 0.068
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRT 229
EV FT ++ E+ +K+ GF Y+ + + + +++ + + DL + +
Sbjct: 422 EVAFTVLFDLEALLKIWCLGFT----GYISSSLHKFELLLVIGTTLHVYPDLYH-SQFTY 476
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
F+VLR ++ + I P L+ V + K L +++ T L V + + LQ++ V
Sbjct: 477 FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Query: 290 VKVFPED--GSWGNLTDENW 307
FP + LT E W
Sbjct: 537 FTTFPRAFMSMFQILTQEGW 556
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/110 (20%), Positives = 53/110 (48%), Gaps = 1/110 (0%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++ ++ F +++M+ + + A + D Y + FTV+F +E L+K
Sbjct: 379 KMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIW 438
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
LGF Y +++ + ++V+ + ++ L + F+ +R +R ++
Sbjct: 439 CLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHS-QFTYFQVLRVVRLIK 487
Score = 33.5 bits (73), Expect = 7.8
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 126 PFNPIRRVAIY-ILVHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYT 178
P N R +Y I HP F I +L +L+ + P T + + V+FT I+
Sbjct: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFV 1253
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKT 238
E +K++A + P + + N D +V +L V + + + A L + + +
Sbjct: 1254 LEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVL---HFALLNAYTYM--MGA 1304
Query: 239 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
IV +I G + ++K L ++++M+ S F ++G+
Sbjct: 1305 CVIVFRFFSICGKHV-TLKMLLLTVVVSMYK-SFFIIVGM 1342
>AL138707-1|CAI40711.1| 1738|Homo sapiens voltage gated channel like 1
protein.
Length = 1738
Score = 165 bits (400), Expect = 2e-39
Identities = 169/646 (26%), Positives = 289/646 (44%), Gaps = 59/646 (9%)
Query: 1218 TYFETAVITMILLSSLALALEDV--HLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALG 1275
TY + +I + + S +++ E + H P LQ Y +F + IE+ +K +A G
Sbjct: 886 TYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEY----VFVIFMSIELNLKIMADG 941
Query: 1276 FQKYFTNAWCWLDF------IIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
+FT DF I +VSLI + + LR LRPLR
Sbjct: 942 L--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKL 999
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN--------- 1380
+ MR VV L IF V ++ L L+FA GVQLFAGK KC D N
Sbjct: 1000 VPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNG 1059
Query: 1381 --------HTTLSHEIIP-DKNACTLENYTWENSP-MNFDHVGKAYLCLFQVATFKGWIQ 1430
L+ ++ P +K W N NFD+VG A L LF+V + KGW++
Sbjct: 1060 IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVE 1119
Query: 1431 IMNDAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGS 1490
+ D I R VG PI I+++++ L LF+GV+I NFNE K A
Sbjct: 1120 V-RDVIIHR-VG--PIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGTA--- 1166
Query: 1491 LEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP-QAIVFEIVTDKKFDMIIMLFIGLN 1549
+T DQ+++ + ++ +PL PRP +A +++I F I L +
Sbjct: 1167 ---LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQ 1223
Query: 1550 MLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPW-NLFDFVVVM 1608
+ +++ + + + L ++++F IF E +KI A+ F + N +D +V
Sbjct: 1224 SVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1282
Query: 1609 FSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNI 1668
++ +VL + + V+ V R + ++ LL + +S+ F I
Sbjct: 1283 LGVVWVVLHFALLNAYTYMMGACVI----VFRFFSICGKHVTLKMLLLTVVVSMYKSFFI 1338
Query: 1669 CLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGI 1728
+ +FL++ +A G+ F VK ++ NF + +++ +LF++ T W+ ++
Sbjct: 1339 IVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1398
Query: 1729 INEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYS--QATED 1786
+ + PD +CG+ + Y S+ VI I++N+ +A+I+EN+S +TE+
Sbjct: 1399 MVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1458
Query: 1787 VQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQI 1832
Q L+ +D + IW D I ++ L +L L++
Sbjct: 1459 DQL-LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV 1503
Score = 107 bits (258), Expect = 3e-22
Identities = 139/589 (23%), Positives = 254/589 (43%), Gaps = 84/589 (14%)
Query: 1244 HRPILQDILYYMDRIFTVIFFIEML----IKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P LQ + + +D + ++ EM+ I+ + G Y + WC D +V ++
Sbjct: 63 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSL 122
Query: 1300 VAALCGAGGIQ-------AFKTMRTLRALRPLRAMSRMQGMRV-VVNALVQAIPSIFNVL 1351
V + I + R L +R R R + R + N L ++ I++V
Sbjct: 123 VLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 182
Query: 1352 LVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT-----TLSHEIIPDKNA------------ 1394
+ L F L++ I+GVQ+F + CV +N T T + IPD +
Sbjct: 183 IFLLFFLLLYGILGVQMFGTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPP 241
Query: 1395 ---CT-LENYTWENSPMN---FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR 1447
C LE+ + F+ +G + +++ A+ +GW+ +M AIDS R
Sbjct: 242 GFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRS--- 298
Query: 1448 ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNE---QKKKAGGSLEMFMTEDQKKYYN 1504
Y Y N+FI VII+ F E Q ++ GS + + ++
Sbjct: 299 ------YFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFH 352
Query: 1505 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
G + + +P+ R A + +++ F M I+ + ++++ ++Y+ E F
Sbjct: 353 EDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYK-GENF 411
Query: 1565 SAVLD--YL-NMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDII 1620
D YL + F V+F E LLKI+ L + Y + F+ ++V+ + L V D+
Sbjct: 412 RRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-VYPDLY 470
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
F +LRVVR+ K+ L + +F L +L L +VM +
Sbjct: 471 HSQFTYFQVLRVVRLIKISPAL------EDFVYKIFGPGKKLGSLVVFTASLLIVM---S 521
Query: 1681 IFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNE 1740
+ F V++ LD F TF ++ + +FQ+ T GW V+D +N
Sbjct: 522 AISLQMFCFVEE---LD---RFTTFPRAFMSMFQILTQEGWVDVMDQTLN---------- 565
Query: 1741 RGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ G+ + + I Y + Y + + LI++++++AVIL+N + ED+++
Sbjct: 566 --AVGHMWAPVVAI-YFILYHLFATLILLSLFVAVILDNL-ELDEDLKK 610
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/165 (27%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 138 LVHPLFSLFIITTILVNCILMIMPT-------TPTVESTEVIFTGIYTFESAVKVMARGF 190
LV L + II TI +CI M+ + PT++ E +F + E +K+MA G
Sbjct: 884 LVTYLDWVMIIVTIC-SCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
Query: 191 ILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAA------LRTFRVLRALKTVAIVPG 244
P +RD +D + ++ + + N+ A L R LR L+ +VP
Sbjct: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
Query: 245 LKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
++ +V + K + V IL + + VFA G+Q++ G L KC
Sbjct: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA-KC 1046
Score = 50.8 bits (116), Expect = 5e-05
Identities = 54/291 (18%), Positives = 121/291 (41%), Gaps = 25/291 (8%)
Query: 139 VHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
VH L + I +++ C+ M P + + + +YT E K+ RG +
Sbjct: 38 VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVK 97
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA----ALRTFRVLRALKTVAIVPGLK-- 246
+Y++D W D ++ +V++ + + +A + + +LR + + ++ +
Sbjct: 98 GDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIY 157
Query: 247 --------TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV--KVFPED 296
I + S + + V I +F L ++ ++G+Q++ G T CV P +
Sbjct: 158 FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGN 216
Query: 297 GSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
+W +L + + E + G + G + E GY G + Y +
Sbjct: 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQLFFVVIIFLGSFYLVNLILAIVAMSY 407
GW FL + + W + + +F+ +IF ++ + N+ +A++ ++
Sbjct: 277 ASQEGWVFLMYRAIDSFPRWRSYF--YFITLIFFLAWLVKNVFIAVIIETF 325
Score = 40.3 bits (90), Expect = 0.068
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRT 229
EV FT ++ E+ +K+ GF Y+ + + + +++ + + DL + +
Sbjct: 422 EVAFTVLFDLEALLKIWCLGFT----GYISSSLHKFELLLVIGTTLHVYPDLYH-SQFTY 476
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
F+VLR ++ + I P L+ V + K L +++ T L V + + LQ++ V
Sbjct: 477 FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Query: 290 VKVFPED--GSWGNLTDENW 307
FP + LT E W
Sbjct: 537 FTTFPRAFMSMFQILTQEGW 556
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/110 (20%), Positives = 53/110 (48%), Gaps = 1/110 (0%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++ ++ F +++M+ + + A + D Y + FTV+F +E L+K
Sbjct: 379 KMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIW 438
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
LGF Y +++ + ++V+ + ++ L + F+ +R +R ++
Sbjct: 439 CLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHS-QFTYFQVLRVVRLIK 487
Score = 33.5 bits (73), Expect = 7.8
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 126 PFNPIRRVAIY-ILVHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYT 178
P N R +Y I HP F I +L +L+ + P T + + V+FT I+
Sbjct: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFV 1253
Query: 179 FESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKT 238
E +K++A + P + + N D +V +L V + + + A L + + +
Sbjct: 1254 LEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVL---HFALLNAYTYM--MGA 1304
Query: 239 VAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 278
IV +I G + ++K L ++++M+ S F ++G+
Sbjct: 1305 CVIVFRFFSICGKHV-TLKMLLLTVVVSMYK-SFFIIVGM 1342
>AJ580918-1|CAE45644.1| 119|Homo sapiens voltage-gated sodium
channel alpha subunit Nav1.7 protein.
Length = 119
Score = 161 bits (390), Expect = 3e-38
Identities = 74/115 (64%), Positives = 90/115 (78%), Gaps = 2/115 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LRVFKLAKSWPTLN+LI I G ++GALGNLT VL II+FIFAV+GMQLFGK+Y + V +
Sbjct: 1 LRVFKLAKSWPTLNMLIKITGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 60
Query: 893 PDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVVI 945
D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ ++ +VI
Sbjct: 61 NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVI 115
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/48 (37%), Positives = 28/48 (58%)
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV +L K + L+ S+ AL N+ L+L +++FIFA+ GM F
Sbjct: 2 RVFKLAKSWPTLNMLIKITGNSVGALGNLTLVLAIIVFIFAVVGMQLF 49
Score = 34.3 bits (75), Expect = 4.5
Identities = 16/57 (28%), Positives = 30/57 (52%)
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
LR + + +++ ++ ++ N+ LV I IFA++G+QLF Y +CV
Sbjct: 1 LRVFKLAKSWPTLNMLIKITGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 57
>AJ580919-1|CAE45645.1| 119|Homo sapiens voltage-gated sodium
channel alpha subunit Nav1.7 protein.
Length = 119
Score = 159 bits (385), Expect = 1e-37
Identities = 73/115 (63%), Positives = 90/115 (78%), Gaps = 2/115 (1%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
LRVFKLAKSWPTLN+LI I+G ++GALGN T VL II+FIFAV+GMQLFGK+Y + V +
Sbjct: 1 LRVFKLAKSWPTLNMLIKIIGNSVGALGNHTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 60
Query: 893 PDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCM-LVGDVSCIPFFLATVVI 945
D LPRW+ DF HSF+IVFRVLCGEWIE+MWDCM + G C+ ++ +VI
Sbjct: 61 NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVI 115
Score = 35.9 bits (79), Expect = 1.5
Identities = 18/48 (37%), Positives = 28/48 (58%)
Query: 1640 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV +L K + L+ + S+ AL N L+L +++FIFA+ GM F
Sbjct: 2 RVFKLAKSWPTLNMLIKIIGNSVGALGNHTLVLAIIVFIFAVVGMQLF 49
Score = 33.9 bits (74), Expect = 5.9
Identities = 16/57 (28%), Positives = 30/57 (52%)
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCV 1377
LR + + +++ + ++ ++ N LV I IFA++G+QLF Y +CV
Sbjct: 1 LRVFKLAKSWPTLNMLIKIIGNSVGALGNHTLVLAIIVFIFAVVGMQLFGKSYKECV 57
>DQ494478-1|ABF69929.1| 2246|Homo sapiens T calcium channel alpha 1G
subunit variant 473-d81 protein.
Length = 2246
Score = 156 bits (378), Expect = 9e-37
Identities = 92/330 (27%), Positives = 176/330 (53%), Gaps = 21/330 (6%)
Query: 1472 FIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW----RPQA 1527
F+GV+++NF++ ++ E + + ++ K+ +A +P + R +
Sbjct: 1505 FVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRL 1564
Query: 1528 IVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKI 1587
+V + T D+ I IGLN++TM ++HYQQ + L N IF VIF E + K+
Sbjct: 1565 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1624
Query: 1588 FALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVVRVAKVGRVLRL 1644
A + +F + WN D +V+ SI+ + L +I ++PT++R++RV ++ RVL+L
Sbjct: 1625 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1684
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDV 1699
+K A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D+ GL
Sbjct: 1685 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRH 1744
Query: 1700 YNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLS 1759
F+ F + + LF++ST W+G++ + +CD C + I Y +S
Sbjct: 1745 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVS 1795
Query: 1760 YLVISFLIVINMYIAVILENYSQATEDVQE 1789
+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 FVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1825
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1554 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1611
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1612 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1671
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1672 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1729
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1730 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1771
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1772 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1829
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1680 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1737
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1738 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1774
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1562 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1611
>DQ494479-1|ABF69930.1| 2287|Homo sapiens T calcium channel alpha 1G
subunit variant 477 protein.
Length = 2287
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 149 bits (360), Expect = 1e-34
Identities = 94/327 (28%), Positives = 171/327 (52%), Gaps = 23/327 (7%)
Query: 1477 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKP--LKAIPRPRW----RPQAIVF 1530
+D N K + E ++K+ KK SK+ +A +P + R + +V
Sbjct: 1501 VDQQNFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVH 1560
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+ T D+ I IGLN++TM ++HYQQ + L N IF VIF E + K+ A
Sbjct: 1561 HLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAF 1620
Query: 1591 RYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVVRVAKVGRVLRLVKG 1647
+ +F + WN D +V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K
Sbjct: 1621 GFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKM 1680
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNF 1702
A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D+ GL F
Sbjct: 1681 AVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATF 1740
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
+ F + + LF++ST W+G++ + +CD C + I Y +S+++
Sbjct: 1741 RNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVL 1791
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQE 1789
+ +++N+ IAV++++ ++ ++ +E
Sbjct: 1792 TAQFVLVNVVIAVLMKHLEESNKEAKE 1818
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1547 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1604
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1605 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1664
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1665 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1722
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1723 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1764
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1765 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1822
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1673 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1730
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1731 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1767
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1555 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1604
>DQ494476-1|ABF69927.1| 2239|Homo sapiens T calcium channel alpha 1G
subunit variant 473 protein.
Length = 2239
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 149 bits (360), Expect = 1e-34
Identities = 94/327 (28%), Positives = 171/327 (52%), Gaps = 23/327 (7%)
Query: 1477 IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKP--LKAIPRPRW----RPQAIVF 1530
+D N K + E ++K+ KK SK+ +A +P + R + +V
Sbjct: 1501 VDQQNFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVH 1560
Query: 1531 EIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFAL 1590
+ T D+ I IGLN++TM ++HYQQ + L N IF VIF E + K+ A
Sbjct: 1561 HLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAF 1620
Query: 1591 RYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVVRVAKVGRVLRLVKG 1647
+ +F + WN D +V+ SI+ + L +I ++PT++R++RV ++ RVL+L+K
Sbjct: 1621 GFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKM 1680
Query: 1648 AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GGLDDVYNF 1702
A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D+ GL F
Sbjct: 1681 AVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATF 1740
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
+ F + + LF++ST W+G++ + +CD C + I Y +S+++
Sbjct: 1741 RNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPIYFVSFVL 1791
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQE 1789
+ +++N+ IAV++++ ++ ++ +E
Sbjct: 1792 TAQFVLVNVVIAVLMKHLEESNKEAKE 1818
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1547 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1604
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1605 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1664
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1665 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1722
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1723 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1764
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1765 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1822
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1673 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1730
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1731 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1767
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1555 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1604
>DQ494475-1|ABF69926.1| 2257|Homo sapiens T calcium channel alpha 1G
subunit variant 441-d81 protein.
Length = 2257
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 151 bits (366), Expect = 2e-35
Identities = 96/341 (28%), Positives = 179/341 (52%), Gaps = 32/341 (9%)
Query: 1472 FIGVIIDNFN-----EQKKKAGGSLEMFMTEDQKKYYNAMKK--MGSKKPLKAIPRPRWR 1524
F+GV+++NF+ +++++A E + +KK N M + S A + +
Sbjct: 1505 FVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCK 1564
Query: 1525 P--------QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFI 1576
P + +V + T D+ I IGLN++TM ++HYQQ + L N IF
Sbjct: 1565 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFT 1624
Query: 1577 VIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVV 1633
VIF E + K+ A + +F + WN D +V+ SI+ + L +I ++PT++R++
Sbjct: 1625 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1684
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-D 1692
RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D
Sbjct: 1685 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1744
Query: 1693 K----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCG 1748
+ GL F+ F + + LF++ST W+G++ + +CD C
Sbjct: 1745 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCY 1795
Query: 1749 SATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+ I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1836
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1565 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1622
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1623 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1682
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1683 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1740
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1741 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1782
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1783 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1840
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1691 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1748
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1749 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1785
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1573 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1622
>DQ494474-1|ABF69925.1| 2250|Homo sapiens T calcium channel alpha 1G
subunit variant 441 protein.
Length = 2250
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 148 bits (358), Expect = 2e-34
Identities = 83/274 (30%), Positives = 151/274 (55%), Gaps = 17/274 (6%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + +V + T D+ I IGLN++TM ++HYQQ + L N IF VIF E
Sbjct: 1565 RFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLES 1624
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVVRVAKVGR 1640
+ K+ A + +F + WN D +V+ SI+ + L +I ++PT++R++RV ++ R
Sbjct: 1625 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIAR 1684
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GG 1695
VL+L+K A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D+ G
Sbjct: 1685 VLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEG 1744
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
L F+ F + + LF++ST W+G++ + +CD C + I
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPI 1795
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1796 YFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1558 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1615
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1733
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1734 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1775
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1776 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1833
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1684 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1741
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1742 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1778
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1566 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615
>DQ494473-1|ABF69924.1| 2232|Homo sapiens T calcium channel alpha 1G
subunit variant 409 protein.
Length = 2232
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1501 VDQQ 1504
Score = 149 bits (361), Expect = 1e-34
Identities = 87/299 (29%), Positives = 159/299 (53%), Gaps = 17/299 (5%)
Query: 1499 QKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHY 1558
++K ++K K K R + +V + T D+ I IGLN++TM ++HY
Sbjct: 1522 EEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHY 1581
Query: 1559 QQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLS 1617
QQ + L N IF VIF E + K+ A + +F + WN D +V+ SI+ + L
Sbjct: 1582 QQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLE 1641
Query: 1618 DIIEKYF--VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1675
+I ++PT++R++RV ++ RVL+L+K A G+R LL + +LP + N+ LL L+
Sbjct: 1642 EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLL 1701
Query: 1676 MFIFAIFGMSFFMHVK-DK----GGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIIN 1730
FIFA G+ F ++ D+ GL F+ F + + LF++ST W+G++ +
Sbjct: 1702 FFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL- 1760
Query: 1731 EEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
+CD C + I Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1761 -RDCD-------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1811
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1540 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1597
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1598 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1657
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1658 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1715
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1716 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1757
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1758 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1815
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1666 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1723
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1724 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1760
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1548 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1597
>DQ494472-1|ABF69923.1| 2227|Homo sapiens T calcium channel alpha 1G
subunit variant 313 protein.
Length = 2227
Score = 154 bits (374), Expect = 3e-36
Identities = 82/244 (33%), Positives = 142/244 (58%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1420
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 1421 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1441 VGRQ 1444
V +Q
Sbjct: 1478 VDQQ 1481
Score = 148 bits (358), Expect = 2e-34
Identities = 83/274 (30%), Positives = 151/274 (55%), Gaps = 17/274 (6%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSEC 1583
R + +V + T D+ I IGLN++TM ++HYQQ + L N IF VIF E
Sbjct: 1542 RFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLES 1601
Query: 1584 LLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDIIEKYF--VSPTLLRVVRVAKVGR 1640
+ K+ A + +F + WN D +V+ SI+ + L +I ++PT++R++RV ++ R
Sbjct: 1602 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIAR 1661
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK-DK----GG 1695
VL+L+K A G+R LL + +LP + N+ LL L+ FIFA G+ F ++ D+ G
Sbjct: 1662 VLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEG 1721
Query: 1696 LDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGIT 1755
L F+ F + + LF++ST W+G++ + +CD C + I
Sbjct: 1722 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL--RDCD-------QESTCYNTVISPI 1772
Query: 1756 YLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1789
Y +S+++ + +++N+ IAV++++ ++ ++ +E
Sbjct: 1773 YFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1806
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 102 bits (244), Expect = 1e-20
Identities = 77/300 (25%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 1199 PFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRI 1258
P++ + RL L + Y + + +I L+ + +A+E P IL + L + I
Sbjct: 1535 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQ--ILDEALKICNYI 1592
Query: 1259 FTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGI-----QAFK 1313
FTVIF +E + K +A GF+++F + W LD IV++S++ +
Sbjct: 1593 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1652
Query: 1314 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKY 1373
MR LR R L+ + GMR +++ ++QA+P + N+ L+ ++ + IFA +GV+LF
Sbjct: 1653 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD-- 1710
Query: 1374 FKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMN 1433
+C D H P + F + G A+L LF+V+T W IM
Sbjct: 1711 LEC-DETH--------PCEGL---------GRHATFRNFGMAFLTLFRVSTGDNWNGIMK 1752
Query: 1434 DAIDSREVGRQPIRETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKKAGGSLEM 1493
D + R+ ++ + +Y +N+ I V++ + E K+A E+
Sbjct: 1753 DTL--RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1810
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1292
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1352
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1353 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1412
Query: 283 G 283
G
Sbjct: 1413 G 1413
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1296
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1473
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 834 RVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFP 893
RV KL K + L+ + + + +GNL + ++ FIFA +G++LFG D + P
Sbjct: 1661 RVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD--ETHP 1718
Query: 894 DGDLPRW-NFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
L R F +F +F+ +FRV G+ W M D +
Sbjct: 1719 CEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1755
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1329 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1388
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1389 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/50 (36%), Positives = 31/50 (62%)
Query: 784 FQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYL 833
F+ V L +++LFIT I +N + MA++H+ + +D+ALK NY+
Sbjct: 1543 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1592
>AF029228-1|AAD12731.1| 319|Homo sapiens T-type calcium channel
alpha1G protein.
Length = 319
Score = 153 bits (372), Expect = 5e-36
Identities = 82/244 (33%), Positives = 141/244 (57%), Gaps = 12/244 (4%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 81 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 140
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y + W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 141 TVKVVALGWCFGEQAYLRSIWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 200
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 201 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 258
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRE 1440
T + I +K+ C +Y W NFD++G+A + LF +A+ GW+ IM D +D+
Sbjct: 259 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 315
Query: 1441 VGRQ 1444
V +Q
Sbjct: 316 VDQQ 319
Score = 78.6 bits (185), Expect = 2e-13
Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 72 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 130
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR WN LD +++ ++ + + + LG
Sbjct: 131 IFTAVFLAEMTVKVVALGWCFGEQAYLRSIWNVLDGLLVLISVIDILVSMVSDSGTKILG 190
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 191 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 250
Query: 283 G 283
G
Sbjct: 251 G 251
Score = 78.2 bits (184), Expect = 3e-13
Identities = 60/237 (25%), Positives = 118/237 (49%), Gaps = 30/237 (12%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 76 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 134
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 135 VFLAEMTVKVVALGWCFGEQAYLRSIWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 194
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF----- 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 195 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 254
Query: 1688 -------MHVKDKGGLDDV--------YNFKTFVQSMILLFQMSTSAGW-DGVLDGI 1728
++ +K + YNF Q+++ LF +++ GW D + DG+
Sbjct: 255 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 311
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 167 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 226
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 227 IGNIVVICCAFFIIFGILGVQLFKGKFFV 255
>EF092294-1|ABN50063.1| 128|Homo sapiens cardiac sodium channel alpha
subunit variant protein.
Length = 128
Score = 149 bits (362), Expect = 8e-35
Identities = 66/125 (52%), Positives = 95/125 (76%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC++
Sbjct: 4 QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV 63
Query: 1586 KIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLV 1645
K+ ALR++YF WN+FDFVVV+ SI+ VLSDII+KYF SPTL RV+R+A++GR+LRL+
Sbjct: 64 KLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLI 123
Query: 1646 KGAKG 1650
+GAKG
Sbjct: 124 RGAKG 128
Score = 44.4 bits (100), Expect = 0.004
Identities = 26/90 (28%), Positives = 50/90 (55%), Gaps = 5/90 (5%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALE-DVHLPHRPILQDILYYMDRIFTVIFFIEMLIK 1270
F ++ F+ ++ +I L+ + + +E D P + +IL ++ +F IF E ++K
Sbjct: 8 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKI---NILAKINLLFVAIFTGECIVK 64
Query: 1271 WLALGFQKYFTNAWCWLDFIIVMVSLINFV 1300
AL YFTN+W DF++V++S++ V
Sbjct: 65 LAALRHY-YFTNSWNIFDFVVVILSIVGTV 93
>M57972-1|AAB59461.1| 294|Homo sapiens cardiac L-type calcium channel
alpha-1 protein.
Length = 294
Score = 133 bits (322), Expect = 5e-30
Identities = 88/295 (29%), Positives = 159/295 (53%), Gaps = 23/295 (7%)
Query: 1473 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEI 1532
+G +I F EQ ++ + E+ + Q Y A+K +PL+ P+ + Q V+ +
Sbjct: 1 VGFVIVTFQEQGEQEYKNCELDKNQRQCVEY-ALKA----RPLRRYI-PKNQHQYKVWYV 54
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR- 1591
V F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E +LK+ A +
Sbjct: 55 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 114
Query: 1592 YHYFVEPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGR 1640
YF +PWN+FDF++V+ SI+ ++LS+ E SP++ + R+ +V R
Sbjct: 115 KGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMR 174
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDD 1698
+++L+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++
Sbjct: 175 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 234
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSA 1750
NF+TF Q+++LLF+ +T W ++ + ++C P N CGS+
Sbjct: 235 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 289
Score = 75.4 bits (177), Expect = 2e-12
Identities = 63/237 (26%), Positives = 122/237 (51%), Gaps = 39/237 (16%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 50 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 107
Query: 1270 KWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCG-AGGIQAFKTM------------- 1315
K +A + YF++ W DF+IV+ S+I+ + + A Q +M
Sbjct: 108 KLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFF 167
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1375
R R +R ++ +SR +G+R ++ +++ ++ V L+ ++ + I+A++G+Q+F GK
Sbjct: 168 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GK--- 223
Query: 1376 CVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIM 1432
+ +N TT EI N NF +A L LF+ AT + W IM
Sbjct: 224 -IALNDTT---EI---------------NRNNNFQTFPQAVLLLFRCATGEAWQDIM 261
Score = 46.4 bits (105), Expect = 0.001
Identities = 38/173 (21%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 53 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 111
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y D WN DF+++ + + + + N + R
Sbjct: 112 ---FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFR 168
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 169 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 221
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 173 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 232
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 233 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 265
>AB012043-1|BAA36409.1| 1555|Homo sapiens NBR13 protein.
Length = 1555
Score = 130 bits (314), Expect = 5e-29
Identities = 70/214 (32%), Positives = 123/214 (57%), Gaps = 12/214 (5%)
Query: 1208 RLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEM 1267
RL ++I + F+ V+ +I L+ + +A+E + + L + IFT +F EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1268 LIKWLALGF----QKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF---KTMRTLRA 1320
+K +ALG+ Q Y ++W LD ++V++S+I+ + ++ G + + +R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1321 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMN 1380
LRPLR +SR QG+++VV L+ ++ I N++++C F++IF I+GVQLF GK+F C
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC--QG 1443
Query: 1381 HTTLSHEIIPDKNACTLENYTWENSPMNFDHVGK 1414
T + I +K+ C +Y W NFD++G+
Sbjct: 1444 EDTRN---ITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 95.5 bits (227), Expect = 2e-18
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVL 1725
D NF + + +++ +FQ+ T W+ VL
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVL 929
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/181 (25%), Positives = 91/181 (50%), Gaps = 20/181 (11%)
Query: 122 WILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVES----------TEV 171
+I P + R + I+ H +F ++ I +NCI + M P ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNY 1315
Query: 172 IFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGID---------LG 222
IFT ++ E VKV+A G+ YLR +WN LD +++ ++ + + + LG
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG 1375
Query: 223 NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYM 282
L LR R LR L+ ++ GLK +V ++ S+K + +++++ +F ++G+Q++
Sbjct: 1376 MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFK 1435
Query: 283 G 283
G
Sbjct: 1436 G 1436
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/272 (23%), Positives = 128/272 (47%), Gaps = 38/272 (13%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQK 1484
LY NL + ++++ F ++
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 78.2 bits (184), Expect = 3e-13
Identities = 48/175 (27%), Positives = 94/175 (53%), Gaps = 9/175 (5%)
Query: 1521 PRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYL---NMIFIV 1577
P+ R + + I+T K FD ++++ I LN +T+ ++ + + SA +L N IF
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTA 1319
Query: 1578 IFSSECLLKIFALRY-----HYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRV 1632
+F +E +K+ AL + Y WN+ D ++V+ S++ +++S + + +LRV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
Query: 1633 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
+R+ + R LR++ A+G++ ++ L SL + NI ++ IF I G+ F
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 37.1 bits (82), Expect = 0.63
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 1/89 (1%)
Query: 799 LFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGA 858
L + + ++ + M D M + L+ LR ++ L L++ + ++
Sbjct: 1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKP 1411
Query: 859 LGNLTFVLCIIIFIFAVMGMQLF-GKNYV 886
+GN+ + C IF ++G+QLF GK +V
Sbjct: 1412 IGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
>M57971-1|AAA62832.1| 294|Homo sapiens L-type calcium channel alpha-1
protein.
Length = 294
Score = 129 bits (311), Expect = 1e-28
Identities = 85/295 (28%), Positives = 157/295 (53%), Gaps = 23/295 (7%)
Query: 1473 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEI 1532
+G +I F EQ ++ + E+ + Q Y A+K +PL+ P+ + Q V+ +
Sbjct: 1 VGFVIVTFQEQGEQEYKNCELDKNQRQCVEY-ALKA----RPLRRYI-PKNQHQYKVWYV 54
Query: 1533 VTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALR- 1591
V F+ ++ + I LN + + + HY QS F ++ LNM+F +F+ E +LK+ A +
Sbjct: 55 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 114
Query: 1592 YHYFVEPWNLFDFVVVMFSILSLVLSDI--IEKYFVSPTL---------LRVVRVAKVGR 1640
HYF + WN FD ++V+ SI+ + ++++ E SP++ + R+ +V R
Sbjct: 115 KHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMR 174
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKDKGGLDD 1698
+++L+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM F + + D ++
Sbjct: 175 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 234
Query: 1699 VYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDNERGSPGNCGSA 1750
NF+TF Q+++LLF+ +T W ++ + ++C P N CGS+
Sbjct: 235 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 289
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/237 (26%), Positives = 121/237 (51%), Gaps = 39/237 (16%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 50 KVWYVVNSTYFEYLMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 107
Query: 1270 KWLALGFQKYFTNAWCWLDFIIVMVSLINF-VAALCGAGGIQAFKTM------------- 1315
K +A + YF +AW D +IV+ S+++ + + A Q +M
Sbjct: 108 KLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFF 167
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1375
R R +R ++ +SR +G+R ++ +++ ++ V L+ ++ + I+A++G+Q+F GK
Sbjct: 168 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GK--- 223
Query: 1376 CVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIM 1432
+ +N TT EI N NF +A L LF+ AT + W IM
Sbjct: 224 -IALNDTT---EI---------------NRNNNFQTFPQAVLLLFRCATGEAWQDIM 261
Score = 47.2 bits (107), Expect = 6e-04
Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 31/173 (17%)
Query: 136 YILVHPLFSLFIITTILVNCILMIMPTTP-------TVESTEVIFTGIYTFESAVKVMAR 188
Y++ F + IL+N I + M + ++FTG++T E +K++A
Sbjct: 53 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA- 111
Query: 189 GFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALR 228
+P Y DAWN D +++ + V + I N + R
Sbjct: 112 ---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFR 168
Query: 229 TFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
FRV+R +K ++ G++T++ I+S + L V +L + ++A++G+Q++
Sbjct: 169 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 221
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 173 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 232
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 233 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 265
>AJ310893-1|CAC84525.1| 113|Homo sapiens Nav1.5 protein.
Length = 113
Score = 118 bits (283), Expect = 3e-25
Identities = 59/98 (60%), Positives = 79/98 (80%), Gaps = 3/98 (3%)
Query: 214 YVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVF 273
YV+ I LGNL+ALRTFRVLRALKT++++PGLKTIVGA+I+SVK L DV++LT+F LSVF
Sbjct: 15 YVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVF 74
Query: 274 ALMGLQIYMGVLTQKCVKVFPE-DGSWGNLTDEN--WE 308
AL+GLQ++MG L KCV+ F +G+ G++ + WE
Sbjct: 75 ALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWE 112
Score = 53.6 bits (123), Expect = 7e-06
Identities = 29/90 (32%), Positives = 54/90 (60%), Gaps = 5/90 (5%)
Query: 1297 INFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1356
+ +V+ G + A +T R LRA L+ +S + G++ +V AL+Q++ + +V+++ +
Sbjct: 13 VEYVSENIKLGNLSALRTFRVLRA---LKTISVIPGLKTIVGALIQSVKKLADVMVLTVF 69
Query: 1357 FWLIFAIMGVQLFAGKY-FKCVDMNHTTLS 1385
+FA++G+QLF G KCV N T L+
Sbjct: 70 CLSVFALIGLQLFMGNLRHKCV-RNFTALN 98
Score = 37.5 bits (83), Expect = 0.48
Identities = 17/59 (28%), Positives = 33/59 (55%)
Query: 1630 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFM 1688
L +R +V R L+ + G++T++ AL S+ L ++ +L + +FA+ G+ FM
Sbjct: 25 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFM 83
>Z26294-1|CAA81218.1| 574|Homo sapiens L-type Ca2+ channel isoform 1,
neuronal subform protein.
Length = 574
Score = 113 bits (273), Expect = 5e-24
Identities = 70/241 (29%), Positives = 130/241 (53%), Gaps = 16/241 (6%)
Query: 1625 VSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGM 1684
+S T R+ RV R+++L+ +GIRTLL+ S AL + LL+ ++ FI+A+ GM
Sbjct: 8 ISITFFRLFRVM---RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 64
Query: 1685 SFF--MHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEEC---DLPDN 1739
F + + D ++ NF+TF Q+++LLF+ +T W ++ + ++C P N
Sbjct: 65 QVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSN 124
Query: 1740 ERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMY 1799
CGS + + Y +S+ ++ ++IN+++AVI++N+ T D L D +
Sbjct: 125 STEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEF 182
Query: 1800 YEIWQRFDPDGSQYIRYDQLSDFLDVLEPPLQIHK--PNKY---KIISMDIPI-CRGDMM 1853
IW +DP+ I++ + L ++PPL K P++ +++SM++P+ G +M
Sbjct: 183 KRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVM 242
Query: 1854 F 1854
F
Sbjct: 243 F 243
Score = 45.2 bits (102), Expect = 0.002
Identities = 44/175 (25%), Positives = 81/175 (46%), Gaps = 32/175 (18%)
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1375
R R +R ++ +SR +G+R ++ +++ ++ V L+ ++ + I+A++G+Q+F GK
Sbjct: 14 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GK--- 69
Query: 1376 CVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDA 1435
+ +N TT EI N NF +A L LF+ AT + W IM
Sbjct: 70 -IALNDTT---EI---------------NRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 110
Query: 1436 IDSREVG--RQPIRET-------NIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFN 1481
+ ++ +P T + + Y +NLF+ VI+DNF+
Sbjct: 111 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 165
Score = 43.6 bits (98), Expect = 0.007
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 5/97 (5%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRF 892
+R+ KL + L+ ++ AL + ++ ++ FI+AV+GMQ+FGK ++
Sbjct: 19 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI 78
Query: 893 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM 928
+ NF F + +++FR GE W + M CM
Sbjct: 79 NRNN----NFQTFPQAVLLLFRCATGEAWQDIMLACM 111
>AF124351-1|AAD34352.1| 1207|Homo sapiens T-type calcium channel
alpha 1G protein.
Length = 1207
Score = 105 bits (251), Expect = 2e-21
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 46/274 (16%)
Query: 177 YTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA--ALRTFRVLR 234
+ E VK++A G I YL D WN LDF ++ + +DL N++ A+RT RVLR
Sbjct: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
Query: 235 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFP 294
L+ + VP ++ +V +++++ L +V++L F +F ++G+Q++ G+L +C P
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLP 244
Query: 295 EDGSWGNLTD---------------------ENWERFCQNETNWYGEGGDYPLCG----- 328
E+ S D EN R C++ G+GG P CG
Sbjct: 245 ENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304
Query: 329 -NSSGAGQC---EPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQ--- 381
NSS C Y NP G +FD G+A+++ F+++T + W ++
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364
Query: 382 --------LFFVVIIFLGSFYLVNLILAIVAMSY 407
++F+++I +GSF+++NL L ++A +
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Score = 97.5 bits (232), Expect = 4e-19
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 32/280 (11%)
Query: 1523 WRPQAIVFEIVTDKK-FDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSS 1581
WR F + D K F IM+ I +N L+M +++++Q E + L+ N++F +F+
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 1582 ECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGR 1640
E LLK+ + Y P+N+FD V+V+ S+ +V L V+R ++ R
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--------GGGLSVLRTFRLMR 840
Query: 1641 VLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSF----FMHVKDKGGL 1696
VL+LV+ ++ L L ++ + C+LL L +FIF+I GM F +D L
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 1697 DDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITY 1756
D NF + + +++ +FQ+ T W+ VL G +++ Y
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYN-----------------GMASTSSWAALY 943
Query: 1757 LLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDY 1796
++ + ++ N+ +A+++E + QA D + ++ D+
Sbjct: 944 FIALMTFGNYVLFNLLVAILVEGF-QAEGDANKSESEPDF 982
Score = 94.7 bits (225), Expect = 3e-18
Identities = 59/162 (36%), Positives = 91/162 (56%), Gaps = 13/162 (8%)
Query: 1217 NTYFETAVITMILLSSLALAL----EDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
N +FE + +ILL+ + L + ED+ + IL D F +EM++K +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCR--ILQAFDDFIFAFFAVEMVVKMV 137
Query: 1273 ALG-FQK--YFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSR 1329
ALG F K Y + W LDF IV+ ++ + L +F +RT+R LRPLRA++R
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNV----SFSAVRTVRVLRPLRAINR 193
Query: 1330 MQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG 1371
+ MR++V L+ +P + NVLL+C + IF I+GVQL+AG
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 77.8 bits (183), Expect = 4e-13
Identities = 63/271 (23%), Positives = 127/271 (46%), Gaps = 38/271 (14%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++++ YF ++ IL+++L++ +E P L + L + +FT +F +EML+K L
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE--LTNALEISNIVFTSLFALEMLLKLL 795
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQG 1332
G Y N + D +IV++S+ V GG+ +T R +R L+ +R + +Q
Sbjct: 796 VYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ--GGGLSVLRTFRLMRVLKLVRFLPALQR 853
Query: 1333 MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDK 1392
VV L++ + ++ ++ ++F IF+I+G+ LF K+ D + +PD+
Sbjct: 854 QLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDTLPDR 903
Query: 1393 NACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIY 1452
NFD + A + +FQ+ T + W +++ + + S T+ +
Sbjct: 904 K--------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS----------TSSW 939
Query: 1453 MYLYXXXXXXXXXXXTLNLFIGVIIDNFNEQ 1483
LY NL + ++++ F +
Sbjct: 940 AALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 69.7 bits (163), Expect = 1e-10
Identities = 32/120 (26%), Positives = 72/120 (60%), Gaps = 5/120 (4%)
Query: 163 TPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALA-YVTMGIDL 221
T +E + ++FT ++ E +K++ G PF Y+++ +N D V++ ++ + +G
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 222 GNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
G L+ LRTFR++R LK V +P L+ + +++++ N+ +L M + +F+++G+ ++
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 58.0 bits (134), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 1524 RPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSA------VLDYLNMIFIV 1577
RP++ V + F+ I ML I LN +T+ + ++ E + +L +
Sbjct: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGM--FRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 1578 IFSSECLLKIFAL----RYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVV 1633
F+ E ++K+ AL + Y + WN DF +V+ +L L + VS + +R V
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTV 182
Query: 1634 RVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFF 1687
RV R LR + +R L+ L +LP L N+ LL F V FIF I G+ +
Sbjct: 183 RVL---RPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 827 LKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYV 886
L++ +RV KL + P L + ++ +TM + +L + IFIF+++GM LFG +
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA 892
Query: 887 DYVDRFPDGD-LP-RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLVGDVSCIPFFLA 941
+R DGD LP R NF + + + VF++L E W + +++ M +F+A
Sbjct: 893 S--ER--DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIA 946
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 10/92 (10%)
Query: 1395 CTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMY 1454
C+ + +NFD++G A++ +FQV T +GW+ IM +D+ + Y +
Sbjct: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNF 372
Query: 1455 LYXXXXXXXXXXXTLNLFIGVIIDNFNEQKKK 1486
+Y +NL + VI F+E K++
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Score = 38.3 bits (85), Expect = 0.27
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 805 IVVNTLFMALDHHNMDKDMDKALKSGNYLRVFKLAKSWPTLNLLISIMGRTMGALGNLTF 864
++ L +LD N+ A+++ LR + P++ +L++++ T+ LGN+
Sbjct: 160 VIAGMLEYSLDLQNVSFS---AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
Query: 865 VLCIIIFIFAVMGMQLF 881
+ + FIF ++G+QL+
Sbjct: 217 LCFFVFFIFGIVGVQLW 233
Score = 36.7 bits (81), Expect = 0.84
Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 11/63 (17%)
Query: 356 SFDTFGWAFLSAFRLMTQDYWEN-LYQ----------LFFVVIIFLGSFYLVNLILAIVA 404
+FD+ WA ++ F+++TQ+ W LY L+F+ ++ G++ L NL++AI+
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 405 MSY 407
+
Sbjct: 965 EGF 967
>BC028390-1|AAH28390.1| 668|Homo sapiens VGCNL1 protein protein.
Length = 668
Score = 98.7 bits (235), Expect = 2e-19
Identities = 126/530 (23%), Positives = 223/530 (42%), Gaps = 70/530 (13%)
Query: 1244 HRPILQDILYYMDRIFTVIFFIEML----IKWLALGFQKYFTNAWCWLDFIIVMVSLINF 1299
H P LQ + + +D + ++ EM+ I+ + G Y + WC D +V ++
Sbjct: 63 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSL 122
Query: 1300 VAALCGAGGIQ-------AFKTMRTLRALRPLRAMSRMQGMRV-VVNALVQAIPSIFNVL 1351
V + I + R L +R R R + R + N L ++ I++V
Sbjct: 123 VLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVS 182
Query: 1352 LVCLIFWLIFAIMGVQLFAGKYFKCVDMNHT-----TLSHEIIPDKNA------------ 1394
+ L F L++ I+GVQ+F + CV +N T T + IPD +
Sbjct: 183 IFLLFFLLLYGILGVQMFGTFTYHCV-VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPP 241
Query: 1395 ---CT-LENYTWENSPMN---FDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIR 1447
C LE+ + F+ +G + +++ A+ +GW+ +M AIDS R
Sbjct: 242 GFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRS--- 298
Query: 1448 ETNIYMYLYXXXXXXXXXXXTLNLFIGVIIDNFNE---QKKKAGGSLEMFMTEDQKKYYN 1504
Y Y N+FI VII+ F E Q ++ GS + + ++
Sbjct: 299 ------YFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFH 352
Query: 1505 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETF 1564
G + + +P+ R A + +++ F M I+ + ++++ ++Y+ E F
Sbjct: 353 EDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYK-GENF 411
Query: 1565 SAVLD--YL-NMIFIVIFSSECLLKIFALRYH-YFVEPWNLFDFVVVMFSILSLVLSDII 1620
D YL + F V+F E LLKI+ L + Y + F+ ++V+ + L V D+
Sbjct: 412 RRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-VYPDLY 470
Query: 1621 EKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFA 1680
F +LRVVR+ K+ L + +F L +L L +VM +
Sbjct: 471 HSQFTYFQVLRVVRLIKISPAL------EDFVYKIFGPGKKLGSLVVFTASLLIVM---S 521
Query: 1681 IFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIIN 1730
+ F V++ LD F TF ++ + +FQ+ T GW V+D +N
Sbjct: 522 AISLQMFCFVEE---LD---RFTTFPRAFMSMFQILTQEGWVDVMDQTLN 565
Score = 50.8 bits (116), Expect = 5e-05
Identities = 54/291 (18%), Positives = 121/291 (41%), Gaps = 25/291 (8%)
Query: 139 VHPLFSLFIITTILVNCILMIM------PTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
VH L + I +++ C+ M P + + + +YT E K+ RG +
Sbjct: 38 VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVK 97
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLA----ALRTFRVLRALKTVAIVPGLK-- 246
+Y++D W D ++ +V++ + + +A + + +LR + + ++ +
Sbjct: 98 GDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIY 157
Query: 247 --------TIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCV--KVFPED 296
I + S + + V I +F L ++ ++G+Q++ G T CV P +
Sbjct: 158 FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGN 216
Query: 297 GSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTS 356
+W +L + + E + G + G + E GY G + Y +
Sbjct: 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
Query: 357 FDTFGWAFLSAFRLMTQDYWENLYQLFFVVIIFLGSFYLVNLILAIVAMSY 407
GW FL + + W + + +F+ +IF ++ + N+ +A++ ++
Sbjct: 277 ASQEGWVFLMYRAIDSFPRWRSYF--YFITLIFFLAWLVKNVFIAVIIETF 325
Score = 40.3 bits (90), Expect = 0.068
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 170 EVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRT 229
EV FT ++ E+ +K+ GF Y+ + + + +++ + + DL + +
Sbjct: 422 EVAFTVLFDLEALLKIWCLGFT----GYISSSLHKFELLLVIGTTLHVYPDLYH-SQFTY 476
Query: 230 FRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 289
F+VLR ++ + I P L+ V + K L +++ T L V + + LQ++ V
Sbjct: 477 FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Query: 290 VKVFPED--GSWGNLTDENW 307
FP + LT E W
Sbjct: 537 FTTFPRAFMSMFQILTQEGW 556
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/110 (20%), Positives = 53/110 (48%), Gaps = 1/110 (0%)
Query: 1213 KLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWL 1272
K++ ++ F +++M+ + + A + D Y + FTV+F +E L+K
Sbjct: 379 KMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIW 438
Query: 1273 ALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALR 1322
LGF Y +++ + ++V+ + ++ L + F+ +R +R ++
Sbjct: 439 CLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHS-QFTYFQVLRVVRLIK 487
>S69887-1|AAB30530.1| 90|Homo sapiens SCN3A protein.
Length = 90
Score = 94.7 bits (225), Expect = 3e-18
Identities = 53/92 (57%), Positives = 63/92 (68%), Gaps = 7/92 (7%)
Query: 1336 VVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKN-- 1393
VVNAL+ AIPSI NVLLVCLIFWLIF+IMGV LFAGK++ CV+M TT + I D N
Sbjct: 1 VVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNM--TTGNMFDISDVNNL 58
Query: 1394 -ACTL--ENYTWENSPMNFDHVGKAYLCLFQV 1422
C + W+N +NFD+VG YL L QV
Sbjct: 59 SDCQALGKQARWKNVKVNFDNVGAGYLALLQV 90
>S71446-1|AAB31605.1| 94|Homo sapiens brain type I sodium channel
alpha-subunit protein.
Length = 94
Score = 93.9 bits (223), Expect = 5e-18
Identities = 54/96 (56%), Positives = 62/96 (64%), Gaps = 10/96 (10%)
Query: 1335 VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNA 1394
VVVNAL+ AIPSI NVLLVCLIFWLIF+IMGV LFAGK++ C+ N TT I D N
Sbjct: 1 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCI--NTTTGDRFDIEDVNN 58
Query: 1395 CT--------LENYTWENSPMNFDHVGKAYLCLFQV 1422
T E W+N +NFD+VG YL L QV
Sbjct: 59 HTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQV 94
>EF092293-1|ABN50062.1| 102|Homo sapiens cardiac sodium channel alpha
subunit variant protein.
Length = 102
Score = 93.5 bits (222), Expect = 7e-18
Identities = 41/89 (46%), Positives = 62/89 (69%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC++
Sbjct: 4 QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV 63
Query: 1586 KIFALRYHYFVEPWNLFDFVVVMFSILSL 1614
K+ ALR++YF WN+FDFVVV+ SI+ L
Sbjct: 64 KLAALRHYYFTNSWNIFDFVVVILSIVEL 92
Score = 43.6 bits (98), Expect = 0.007
Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 5/87 (5%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALE-DVHLPHRPILQDILYYMDRIFTVIFFIEMLIK 1270
F ++ F+ ++ +I L+ + + +E D P + +IL ++ +F IF E ++K
Sbjct: 8 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKI---NILAKINLLFVAIFTGECIVK 64
Query: 1271 WLALGFQKYFTNAWCWLDFIIVMVSLI 1297
AL YFTN+W DF++V++S++
Sbjct: 65 LAALRHY-YFTNSWNIFDFVVVILSIV 90
>EF092292-1|ABN50061.1| 98|Homo sapiens cardiac sodium channel alpha
subunit variant protein.
Length = 98
Score = 93.5 bits (222), Expect = 7e-18
Identities = 41/91 (45%), Positives = 63/91 (69%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLL 1585
Q +F+IVT + FD+ IM I LNM+TM ++ QS +L +N++F+ IF+ EC++
Sbjct: 4 QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV 63
Query: 1586 KIFALRYHYFVEPWNLFDFVVVMFSILSLVL 1616
K+ ALR++YF WN+FDFVVV+ SI+ +L
Sbjct: 64 KLAALRHYYFTNSWNIFDFVVVILSIVGALL 94
Score = 43.6 bits (98), Expect = 0.007
Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 5/87 (5%)
Query: 1212 FKLIENTYFETAVITMILLSSLALALE-DVHLPHRPILQDILYYMDRIFTVIFFIEMLIK 1270
F ++ F+ ++ +I L+ + + +E D P + +IL ++ +F IF E ++K
Sbjct: 8 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKI---NILAKINLLFVAIFTGECIVK 64
Query: 1271 WLALGFQKYFTNAWCWLDFIIVMVSLI 1297
AL YFTN+W DF++V++S++
Sbjct: 65 LAALRHY-YFTNSWNIFDFVVVILSIV 90
>M91370-1|AAA74590.1| 198|Homo sapiens voltage-gated calcium channel
protein.
Length = 198
Score = 88.6 bits (210), Expect = 2e-16
Identities = 57/180 (31%), Positives = 98/180 (54%), Gaps = 16/180 (8%)
Query: 1515 LKAIPRPRWRP----QAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDY 1570
LKA P R+ P Q V+ +V F+ + + I LN + + + HY QS F ++
Sbjct: 19 LKARPLRRYIPKNXHQYKVWYVVNSTYFEYPMFVLILLNTICLAMQHYGQSCLFKIAMNI 78
Query: 1571 LNMIFIVIFSSECLLKIFALR-YHYFVEPWNLFDFVVVMFSILSLVLSDI--IEKYFVSP 1627
LNM+F +F+ E +LK+ A + HYF + WN FD ++V+ SI+ + ++++ E SP
Sbjct: 79 LNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSP 138
Query: 1628 TL---------LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFI 1678
++ + R+ +V R ++L+ +GIRTLL+ S AL + LL+ ++ FI
Sbjct: 139 SMNAEENSRISITFFRLFRVMRPVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 198
Score = 65.3 bits (152), Expect = 2e-09
Identities = 40/165 (24%), Positives = 91/165 (55%), Gaps = 17/165 (10%)
Query: 1210 KTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLI 1269
K + ++ +TYFE + +ILL+++ LA++ H + + + ++ +FT +F +EM++
Sbjct: 36 KVWYVVNSTYFEYPMFVLILLNTICLAMQ--HYGQSCLFKIAMNILNMLFTGLFTVEMIL 93
Query: 1270 KWLALGFQKYFTNAWCWLDFIIVMVSLINF-VAALCGAGGIQAFKTM------------- 1315
K +A + YF +AW D +IV+ S+++ + + A Q +M
Sbjct: 94 KLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFF 153
Query: 1316 RTLRALRPLRAMSRMQGMRVVVNALVQAIPSI-FNVLLVCLIFWL 1359
R R +RP++ +SR +G+R ++ +++ ++ + LL+ ++F++
Sbjct: 154 RLFRVMRPVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 198
Score = 37.1 bits (82), Expect = 0.63
Identities = 37/153 (24%), Positives = 70/153 (45%), Gaps = 36/153 (23%)
Query: 140 HPLFSLFIITTILV-------NCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFIL 192
+P+F L ++ TI + +C+ I + ++FTG++T E +K++A
Sbjct: 48 YPMFVLILLNTICLAMQHYGQSCLFKI-----AMNILNMLFTGLFTVEMILKLIA----F 98
Query: 193 QPFTYLRDAWNWLDFVVIALAYVTMGIDLGN--------------------LAALRTFRV 232
+P Y DAWN D +++ + V + I N + R FRV
Sbjct: 99 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 158
Query: 233 LRALKTVAIVPGLKTIVGAVIESVKNLRDVIIL 265
+R +K ++ G++T++ I+S + L V +L
Sbjct: 159 MRPVKLLSRGEGIRTLLWTFIKSFQALPYVALL 191
>AY686224-1|AAT95434.1| 153|Homo sapiens voltage-gated sodium channel
Nav1.9 protein.
Length = 153
Score = 87.0 bits (206), Expect = 6e-16
Identities = 44/107 (41%), Positives = 65/107 (60%)
Query: 1170 EDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMIL 1229
E V P C P+ FP + D P W W LR ++++++++FE+ +I +IL
Sbjct: 47 EMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVIL 106
Query: 1230 LSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGF 1276
LSS AL EDVHL ++P Q++L D IFT IF +EM++KW+A GF
Sbjct: 107 LSSGALIFEDVHLENQPKTQELLNCTDIIFTHIFILEMVLKWVAFGF 153
>BC110384-1|AAI10385.1| 398|Homo sapiens cation channel, sperm
associated 3 protein.
Length = 398
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/208 (26%), Positives = 104/208 (50%), Gaps = 8/208 (3%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTL-DHYQQSETFSAVLDYLNMIFIVIFSSECL 1584
+A V ++ + F +I++ + N M L Y +L++ + F+ I +SE
Sbjct: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
+K++ +Y+ +NL D ++++ L L ++ K F T L + + R+L+L
Sbjct: 100 MKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIADGMQSLRILKL 156
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKT 1704
+ ++GIRTL+ A+ ++ + ++ LLLFL+M+IFAI G F D G D N+
Sbjct: 157 IGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF-GSPDNGDHD---NWGN 212
Query: 1705 FVQSMILLFQMSTSAGWDGVLDGIINEE 1732
+ LF ++T GW + + N E
Sbjct: 213 LAAAFFTLFSLATVDGWTDLQKQLDNRE 240
Score = 50.0 bits (114), Expect = 8e-05
Identities = 34/126 (26%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Query: 1250 DILYYMDRI--FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAAL 1303
DI Y + R+ F+ IFF+ + L++ Y+ N + LD II++V + +
Sbjct: 74 DIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQ 133
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+++LR L+ + QG+R ++ A+ Q + ++ +VLL+ + IFAI
Sbjct: 134 LMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAI 193
Query: 1364 MGVQLF 1369
+G LF
Sbjct: 194 LGFCLF 199
Score = 36.7 bits (81), Expect = 0.84
Identities = 16/50 (32%), Positives = 32/50 (64%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFG 882
LR+ KL + LI+ +G+T+ + ++ +L ++++IFA++G LFG
Sbjct: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
>BC101692-1|AAI01693.1| 398|Homo sapiens cation channel, sperm
associated 3 protein.
Length = 398
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/208 (26%), Positives = 104/208 (50%), Gaps = 8/208 (3%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTL-DHYQQSETFSAVLDYLNMIFIVIFSSECL 1584
+A V ++ + F +I++ + N M L Y +L++ + F+ I +SE
Sbjct: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
+K++ +Y+ +NL D ++++ L L ++ K F T L + + R+L+L
Sbjct: 100 MKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIADGMQSLRILKL 156
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKT 1704
+ ++GIRTL+ A+ ++ + ++ LLLFL+M+IFAI G F D G D N+
Sbjct: 157 IGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF-GSPDNGDHD---NWGN 212
Query: 1705 FVQSMILLFQMSTSAGWDGVLDGIINEE 1732
+ LF ++T GW + + N E
Sbjct: 213 LAAAFFTLFSLATVDGWTDLQKQLDNRE 240
Score = 50.0 bits (114), Expect = 8e-05
Identities = 34/126 (26%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Query: 1250 DILYYMDRI--FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAAL 1303
DI Y + R+ F+ IFF+ + L++ Y+ N + LD II++V + +
Sbjct: 74 DIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQ 133
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+++LR L+ + QG+R ++ A+ Q + ++ +VLL+ + IFAI
Sbjct: 134 LMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAI 193
Query: 1364 MGVQLF 1369
+G LF
Sbjct: 194 LGFCLF 199
Score = 36.7 bits (81), Expect = 0.84
Identities = 16/50 (32%), Positives = 32/50 (64%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFG 882
LR+ KL + LI+ +G+T+ + ++ +L ++++IFA++G LFG
Sbjct: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
>AF432876-1|AAO85416.1| 398|Homo sapiens putative one-repeat calcium
channel protein.
Length = 398
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/208 (26%), Positives = 104/208 (50%), Gaps = 8/208 (3%)
Query: 1526 QAIVFEIVTDKKFDMIIMLFIGLNMLTMTL-DHYQQSETFSAVLDYLNMIFIVIFSSECL 1584
+A V ++ + F +I++ + N M L Y +L++ + F+ I +SE
Sbjct: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
+K++ +Y+ +NL D ++++ L L ++ K F T L + + R+L+L
Sbjct: 100 MKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIADGMQSLRILKL 156
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKT 1704
+ ++GIRTL+ A+ ++ + ++ LLLFL+M+IFAI G F D G D N+
Sbjct: 157 IGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF-GSPDNGDHD---NWGN 212
Query: 1705 FVQSMILLFQMSTSAGWDGVLDGIINEE 1732
+ LF ++T GW + + N E
Sbjct: 213 LAAAFFTLFSLATVDGWTDLQKQLDNRE 240
Score = 50.0 bits (114), Expect = 8e-05
Identities = 34/126 (26%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Query: 1250 DILYYMDRI--FTVIFFIEMLIKWLALGFQ----KYFTNAWCWLDFIIVMVSLINFVAAL 1303
DI Y + R+ F+ IFF+ + L++ Y+ N + LD II++V + +
Sbjct: 74 DIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQ 133
Query: 1304 CGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1363
+++LR L+ + QG+R ++ A+ Q + ++ +VLL+ + IFAI
Sbjct: 134 LMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAI 193
Query: 1364 MGVQLF 1369
+G LF
Sbjct: 194 LGFCLF 199
Score = 36.7 bits (81), Expect = 0.84
Identities = 16/50 (32%), Positives = 32/50 (64%)
Query: 833 LRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFG 882
LR+ KL + LI+ +G+T+ + ++ +L ++++IFA++G LFG
Sbjct: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
>AF239921-1|AAF44690.1| 82|Homo sapiens brain type III sodim channel
alpha subunit protein.
Length = 82
Score = 84.6 bits (200), Expect = 3e-15
Identities = 41/82 (50%), Positives = 58/82 (70%), Gaps = 4/82 (4%)
Query: 1679 FAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINE--EECDL 1736
+AIFGMS F +VK + G+DD++NF+TF SMI LFQ++TSAGWDG+L I+N +CD
Sbjct: 1 YAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDP 60
Query: 1737 PDNERGS--PGNCGSATIGITY 1756
GS G+CG+ ++GI +
Sbjct: 61 DTIHPGSSVKGDCGNPSVGIFF 82
>BC064387-1|AAH64387.1| 528|Homo sapiens cation channel, sperm
associated 2 protein.
Length = 528
Score = 83.0 bits (196), Expect = 1e-14
Identities = 54/171 (31%), Positives = 95/171 (55%), Gaps = 7/171 (4%)
Query: 1201 WQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFT 1260
W GW L FK F + T+IL+ + L LE + P L+ L
Sbjct: 100 WAGW-VLECPLFKNF--IIFLVFLNTIILMVEIEL-LESTNTKLWP-LKLTLEVAAWFIL 154
Query: 1261 VIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF-KTMRTLR 1319
+IF +E+L+KWL+ F ++ +AW DF++ M+SL+ V L G G + + +R R
Sbjct: 155 LIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICR 213
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
LR L+ +++ + +++++ LV+A+ S+ +L++ LIF+ IFA+ GV +F+
Sbjct: 214 VLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS 264
Score = 68.9 bits (161), Expect = 2e-10
Identities = 59/283 (20%), Positives = 129/283 (45%), Gaps = 23/283 (8%)
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSET----FSAVLDYLNMIFIVIFSSECL 1584
V E K F +I ++F+ +L + ++ + + T L+ ++IF E L
Sbjct: 104 VLECPLFKNF-IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
LK + ++ WN+FDFVV M S+L V+ ++ L+++R+ +V R L+L
Sbjct: 163 LKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSLKL 220
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN--F 1702
+ + I+ ++ L +L ++ + +LL + +IFA+ G+ F D Y+ F
Sbjct: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFF 280
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
S++ +F + T W +L + E S Y + +L+
Sbjct: 281 SDLPNSLVTVFILFTLDHWYALLQDVWKVPEV--------------SRIFSSIYFILWLL 326
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQR 1805
+ +I ++ +A+++ N+ +++ E + + + ++++R
Sbjct: 327 LGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
Score = 52.4 bits (120), Expect = 2e-05
Identities = 47/169 (27%), Positives = 85/169 (50%), Gaps = 17/169 (10%)
Query: 129 PIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEV-IFTGIYTFESAVKVMA 187
P+ A ++L PLF FII + +N I+ +M +EST ++ T E A +
Sbjct: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTII-LMVEIELLESTNTKLWPLKLTLEVAAWFIL 154
Query: 188 RGFILQPF--------TYLRDAWNWLDFVVIALA-----YVTMGIDLGN--LAALRTFRV 232
FIL+ + + AWN DFVV L+ V +G+ + L LR RV
Sbjct: 155 LIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
Query: 233 LRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
LR+LK +A ++ I+ ++ ++K++ +++L + +FA+ G+ ++
Sbjct: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
>AF411819-1|AAL26492.1| 414|Homo sapiens putative ion channel protein
CATSPER2 variant 3 protein.
Length = 414
Score = 83.0 bits (196), Expect = 1e-14
Identities = 54/171 (31%), Positives = 95/171 (55%), Gaps = 7/171 (4%)
Query: 1201 WQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFT 1260
W GW L FK F + T+IL+ + L LE + P L+ L
Sbjct: 100 WAGW-VLECPLFKNF--IIFLVFLNTIILMVEIEL-LESTNTKLWP-LKLTLEVAAWFIL 154
Query: 1261 VIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF-KTMRTLR 1319
+IF +E+L+KWL+ F ++ +AW DF++ M+SL+ V L G G + + +R R
Sbjct: 155 LIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICR 213
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
LR L+ +++ + +++++ LV+A+ S+ +L++ LIF+ IFA+ GV +F+
Sbjct: 214 VLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS 264
Score = 68.9 bits (161), Expect = 2e-10
Identities = 59/283 (20%), Positives = 129/283 (45%), Gaps = 23/283 (8%)
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSET----FSAVLDYLNMIFIVIFSSECL 1584
V E K F +I ++F+ +L + ++ + + T L+ ++IF E L
Sbjct: 104 VLECPLFKNF-IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
LK + ++ WN+FDFVV M S+L V+ ++ L+++R+ +V R L+L
Sbjct: 163 LKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSLKL 220
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN--F 1702
+ + I+ ++ L +L ++ + +LL + +IFA+ G+ F D Y+ F
Sbjct: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFF 280
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
S++ +F + T W +L + E S Y + +L+
Sbjct: 281 SDLPNSLVTVFILFTLDHWYALLQDVWKVPEV--------------SRIFSSIYFILWLL 326
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQR 1805
+ +I ++ +A+++ N+ +++ E + + + ++++R
Sbjct: 327 LGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
Score = 52.4 bits (120), Expect = 2e-05
Identities = 47/169 (27%), Positives = 85/169 (50%), Gaps = 17/169 (10%)
Query: 129 PIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEV-IFTGIYTFESAVKVMA 187
P+ A ++L PLF FII + +N I+ +M +EST ++ T E A +
Sbjct: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTII-LMVEIELLESTNTKLWPLKLTLEVAAWFIL 154
Query: 188 RGFILQPF--------TYLRDAWNWLDFVVIALA-----YVTMGIDLGN--LAALRTFRV 232
FIL+ + + AWN DFVV L+ V +G+ + L LR RV
Sbjct: 155 LIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
Query: 233 LRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
LR+LK +A ++ I+ ++ ++K++ +++L + +FA+ G+ ++
Sbjct: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
>AF411818-1|AAL26491.1| 530|Homo sapiens putative ion channel protein
CATSPER2 variant 2 protein.
Length = 530
Score = 83.0 bits (196), Expect = 1e-14
Identities = 54/171 (31%), Positives = 95/171 (55%), Gaps = 7/171 (4%)
Query: 1201 WQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFT 1260
W GW L FK F + T+IL+ + L LE + P L+ L
Sbjct: 100 WAGW-VLECPLFKNF--IIFLVFLNTIILMVEIEL-LESTNTKLWP-LKLTLEVAAWFIL 154
Query: 1261 VIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF-KTMRTLR 1319
+IF +E+L+KWL+ F ++ +AW DF++ M+SL+ V L G G + + +R R
Sbjct: 155 LIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICR 213
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
LR L+ +++ + +++++ LV+A+ S+ +L++ LIF+ IFA+ GV +F+
Sbjct: 214 VLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS 264
Score = 68.9 bits (161), Expect = 2e-10
Identities = 59/283 (20%), Positives = 129/283 (45%), Gaps = 23/283 (8%)
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSET----FSAVLDYLNMIFIVIFSSECL 1584
V E K F +I ++F+ +L + ++ + + T L+ ++IF E L
Sbjct: 104 VLECPLFKNF-IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
LK + ++ WN+FDFVV M S+L V+ ++ L+++R+ +V R L+L
Sbjct: 163 LKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSLKL 220
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN--F 1702
+ + I+ ++ L +L ++ + +LL + +IFA+ G+ F D Y+ F
Sbjct: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFF 280
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
S++ +F + T W +L + E S Y + +L+
Sbjct: 281 SDLPNSLVTVFILFTLDHWYALLQDVWKVPEV--------------SRIFSSIYFILWLL 326
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQR 1805
+ +I ++ +A+++ N+ +++ E + + + ++++R
Sbjct: 327 LGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
Score = 52.4 bits (120), Expect = 2e-05
Identities = 47/169 (27%), Positives = 85/169 (50%), Gaps = 17/169 (10%)
Query: 129 PIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEV-IFTGIYTFESAVKVMA 187
P+ A ++L PLF FII + +N I+ +M +EST ++ T E A +
Sbjct: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTII-LMVEIELLESTNTKLWPLKLTLEVAAWFIL 154
Query: 188 RGFILQPF--------TYLRDAWNWLDFVVIALA-----YVTMGIDLGN--LAALRTFRV 232
FIL+ + + AWN DFVV L+ V +G+ + L LR RV
Sbjct: 155 LIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
Query: 233 LRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
LR+LK +A ++ I+ ++ ++K++ +++L + +FA+ G+ ++
Sbjct: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
>AF411817-1|AAL26490.1| 528|Homo sapiens putative ion channel protein
CATSPER2 variant 1 protein.
Length = 528
Score = 83.0 bits (196), Expect = 1e-14
Identities = 54/171 (31%), Positives = 95/171 (55%), Gaps = 7/171 (4%)
Query: 1201 WQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFT 1260
W GW L FK F + T+IL+ + L LE + P L+ L
Sbjct: 100 WAGW-VLECPLFKNF--IIFLVFLNTIILMVEIEL-LESTNTKLWP-LKLTLEVAAWFIL 154
Query: 1261 VIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAF-KTMRTLR 1319
+IF +E+L+KWL+ F ++ +AW DF++ M+SL+ V L G G + + +R R
Sbjct: 155 LIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICR 213
Query: 1320 ALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFA 1370
LR L+ +++ + +++++ LV+A+ S+ +L++ LIF+ IFA+ GV +F+
Sbjct: 214 VLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS 264
Score = 68.9 bits (161), Expect = 2e-10
Identities = 59/283 (20%), Positives = 129/283 (45%), Gaps = 23/283 (8%)
Query: 1529 VFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSET----FSAVLDYLNMIFIVIFSSECL 1584
V E K F +I ++F+ +L + ++ + + T L+ ++IF E L
Sbjct: 104 VLECPLFKNF-IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162
Query: 1585 LKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1644
LK + ++ WN+FDFVV M S+L V+ ++ L+++R+ +V R L+L
Sbjct: 163 LKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSLKL 220
Query: 1645 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYN--F 1702
+ + I+ ++ L +L ++ + +LL + +IFA+ G+ F D Y+ F
Sbjct: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFF 280
Query: 1703 KTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLV 1762
S++ +F + T W +L + E S Y + +L+
Sbjct: 281 SDLPNSLVTVFILFTLDHWYALLQDVWKVPEV--------------SRIFSSIYFILWLL 326
Query: 1763 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQR 1805
+ +I ++ +A+++ N+ +++ E + + + ++++R
Sbjct: 327 LGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKR 369
Score = 52.4 bits (120), Expect = 2e-05
Identities = 47/169 (27%), Positives = 85/169 (50%), Gaps = 17/169 (10%)
Query: 129 PIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEV-IFTGIYTFESAVKVMA 187
P+ A ++L PLF FII + +N I+ +M +EST ++ T E A +
Sbjct: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTII-LMVEIELLESTNTKLWPLKLTLEVAAWFIL 154
Query: 188 RGFILQPF--------TYLRDAWNWLDFVVIALA-----YVTMGIDLGN--LAALRTFRV 232
FIL+ + + AWN DFVV L+ V +G+ + L LR RV
Sbjct: 155 LIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214
Query: 233 LRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIY 281
LR+LK +A ++ I+ ++ ++K++ +++L + +FA+ G+ ++
Sbjct: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263
>AL591424-7|CAI40691.1| 164|Homo sapiens calcium channel,
voltage-dependent, L type, alphamotif, 4 protein.
Length = 164
Score = 82.2 bits (194), Expect = 2e-14
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 11/157 (7%)
Query: 1701 NFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSY 1760
NF+TF+Q+++LLF+ +T W ++ ++ + CD E+ + CGS Y +S+
Sbjct: 1 NFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD----EQANATECGS-DFAYFYFVSF 55
Query: 1761 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLS 1820
+ + +++N+++AVI++N+ T D L D + +W +DP I Y +
Sbjct: 56 IFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIRVWAEYDPAACCRIHYKDMY 114
Query: 1821 DFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDM 1852
L + PP+ + K P + YK ++ M++PI DM
Sbjct: 115 SLLRCIAPPVGLGKNCPRRLAYKRLVRMNMPISNEDM 151
Score = 35.9 bits (79), Expect = 1.5
Identities = 22/75 (29%), Positives = 34/75 (45%), Gaps = 2/75 (2%)
Query: 1408 NFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRET--NIYMYLYXXXXXXXXX 1465
NF +A + LF+ AT + W +IM + ++ Q + + Y Y
Sbjct: 1 NFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCS 60
Query: 1466 XXTLNLFIGVIIDNF 1480
LNLF+ VI+DNF
Sbjct: 61 FLMLNLFVAVIMDNF 75
>M55662-1|AAB65854.2| 70|Homo sapiens type II sodium channel
alpha-subunit protein.
Length = 70
Score = 75.4 bits (177), Expect = 2e-12
Identities = 35/69 (50%), Positives = 51/69 (73%), Gaps = 4/69 (5%)
Query: 1708 SMILLFQMSTSAGWDGVLDGIINE--EECDLPDNERGSP--GNCGSATIGITYLLSYLVI 1763
SMI LFQ++TSAGWDG+L I+N +CD + GS G+CG+ ++GI + +SY++I
Sbjct: 2 SMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIII 61
Query: 1764 SFLIVINMY 1772
SFL+V+NMY
Sbjct: 62 SFLVVVNMY 70
>AJ310885-1|CAC84528.1| 50|Homo sapiens Nav1.6 protein.
Length = 50
Score = 74.5 bits (175), Expect = 3e-12
Identities = 29/43 (67%), Positives = 35/43 (81%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
Y D++FT IF +EML+KW A GF K+FTNAWCWLDF+IV V L
Sbjct: 2 YADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVPL 44
Score = 35.9 bits (79), Expect = 1.5
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI 219
E + +FT I+ E +K A GF+ + +AW WLDF+++A+ G+
Sbjct: 1 EYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVPLNLSGL 49
>AJ310884-1|CAC84527.1| 50|Homo sapiens Nav1.6 protein.
Length = 50
Score = 74.5 bits (175), Expect = 3e-12
Identities = 29/43 (67%), Positives = 35/43 (81%)
Query: 1254 YMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSL 1296
Y D++FT IF +EML+KW A GF K+FTNAWCWLDF+IV V L
Sbjct: 2 YADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVPL 44
Score = 35.9 bits (79), Expect = 1.5
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 167 ESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGI 219
E + +FT I+ E +K A GF+ + +AW WLDF+++A+ G+
Sbjct: 1 EYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVPLNLSGL 49
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.324 0.140 0.428
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 258,529,537
Number of Sequences: 224733
Number of extensions: 10592342
Number of successful extensions: 50005
Number of sequences better than 10.0: 425
Number of HSP's better than 10.0 without gapping: 331
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 39037
Number of HSP's gapped (non-prelim): 5410
length of query: 1969
length of database: 73,234,838
effective HSP length: 101
effective length of query: 1868
effective length of database: 50,536,805
effective search space: 94402751740
effective search space used: 94402751740
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 73 (33.5 bits)
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