Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001556-TA|BGIBMGA001556-PA|IPR005919|Higher eukaryotic
phosphomevalonate kinase
(186 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q2F663 Cluster: Phosphomevalonate kinase; n=3; Endopter... 334 1e-90
UniRef50_UPI00015B527F Cluster: PREDICTED: similar to phosphomev... 177 1e-43
UniRef50_UPI0000D55772 Cluster: PREDICTED: similar to Phosphomev... 169 5e-41
UniRef50_Q15126 Cluster: Phosphomevalonate kinase; n=23; Euteleo... 156 3e-37
UniRef50_Q9VIT2 Cluster: Probable phosphomevalonate kinase; n=6;... 150 2e-35
UniRef50_Q3KPY7 Cluster: MGC131201 protein; n=1; Xenopus laevis|... 134 1e-30
UniRef50_A7RZW5 Cluster: Predicted protein; n=1; Nematostella ve... 126 4e-28
UniRef50_Q86NH2 Cluster: Putative uncharacterized protein; n=2; ... 125 6e-28
UniRef50_Q5DCX3 Cluster: SJCHGC02790 protein; n=3; Schistosoma j... 97 2e-19
UniRef50_Q2GYY3 Cluster: Putative uncharacterized protein; n=2; ... 36 0.77
UniRef50_A1DPA3 Cluster: Ferric-chelate reductase, putative; n=3... 34 2.3
UniRef50_Q0UBI2 Cluster: Putative uncharacterized protein; n=1; ... 32 7.2
>UniRef50_Q2F663 Cluster: Phosphomevalonate kinase; n=3;
Endopterygota|Rep: Phosphomevalonate kinase - Bombyx
mori (Silk moth)
Length = 186
Score = 334 bits (820), Expect = 1e-90
Identities = 160/186 (86%), Positives = 160/186 (86%)
Query: 1 MSPKIILLFSGKRKSGKDFLTDHLRHILADKCEIIKISQPIKTHWAXXXXXXXXXXXSEG 60
MSPKIILLFSGKRKSGKDFLTDHLRHILADKCEIIKISQPIKTHWA SEG
Sbjct: 1 MSPKIILLFSGKRKSGKDFLTDHLRHILADKCEIIKISQPIKTHWAKEKNLNLNELLSEG 60
Query: 61 EYKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDI 120
EYKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDI
Sbjct: 61 EYKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDI 120
Query: 121 IRTVRITADDRTRKERGFQFQVGVDDATSECXXXXXXXXXXXXXXGEGRDSLEEQLDSIL 180
IRTVRITADDRTRKERGFQFQVGVDDATSEC GEGRDSLEE LDSIL
Sbjct: 121 IRTVRITADDRTRKERGFQFQVGVDDATSECDLDDYNDGDVVVNNGEGRDSLEEPLDSIL 180
Query: 181 KLVSNL 186
KLVSNL
Sbjct: 181 KLVSNL 186
>UniRef50_UPI00015B527F Cluster: PREDICTED: similar to
phosphomevalonate kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to phosphomevalonate kinase - Nasonia
vitripennis
Length = 204
Score = 177 bits (432), Expect = 1e-43
Identities = 83/153 (54%), Positives = 107/153 (69%), Gaps = 3/153 (1%)
Query: 2 SPKIILLFSGKRKSGKDFLTDHLRHILA-DKCEIIKISQPIKTHWAXXXXXXXXXXXSEG 60
+P+ IL+FSGKRKSGKDF+TD L L +K IIK+S PIK+HWA +G
Sbjct: 21 NPEKILIFSGKRKSGKDFITDELFARLGKEKSVIIKLSGPIKSHWAKIKNLDAKQLFGDG 80
Query: 61 EYKEQYRLEMIKWSEEMRNKDYGCFCKAAC--ENAAIKPVWIVSDIRRKTDIRWFKETYG 118
EYKE YR EM KW E+ RNKDYG FC+AA NA KP+WI+SD RRKTD++WFKE Y
Sbjct: 81 EYKEAYRREMTKWGEDTRNKDYGYFCRAAILMYNANDKPIWIISDARRKTDLKWFKEHYA 140
Query: 119 DIIRTVRITADDRTRKERGFQFQVGVDDATSEC 151
D +T+RI++ + RK RG++F G+DD+ +EC
Sbjct: 141 DKCKTIRISSSEEVRKNRGWKFCRGIDDSETEC 173
>UniRef50_UPI0000D55772 Cluster: PREDICTED: similar to
Phosphomevalonate kinase (PMKase); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Phosphomevalonate
kinase (PMKase) - Tribolium castaneum
Length = 189
Score = 169 bits (410), Expect = 5e-41
Identities = 83/155 (53%), Positives = 110/155 (70%), Gaps = 5/155 (3%)
Query: 2 SPKIILLFSGKRKSGKDFLTDHLRHILADK-CEIIKISQPIKTHWAXXXXXXXXXXX--- 57
+P++ILLFSGKRKSGKD++ + L+ L D C II+IS P+K +A
Sbjct: 3 NPRLILLFSGKRKSGKDYICEALKANLGDNNCTIIRISGPLKRLYAESHDLTTGDVNEMM 62
Query: 58 SEGEYKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETY 117
++G KE++R EMI+WS+E+R +D+G FCKAA + A +KP WIVSDIRRKTDI WFK TY
Sbjct: 63 TDGPLKEKFRAEMIQWSDEIRGRDFGFFCKAATDLADLKPFWIVSDIRRKTDIHWFKNTY 122
Query: 118 GD-IIRTVRITADDRTRKERGFQFQVGVDDATSEC 151
D II+ +RI AD+ TR++RG+ F GVDD TSEC
Sbjct: 123 KDKIIKLIRIQADEVTRQKRGWVFTEGVDDVTSEC 157
>UniRef50_Q15126 Cluster: Phosphomevalonate kinase; n=23;
Euteleostomi|Rep: Phosphomevalonate kinase - Homo
sapiens (Human)
Length = 192
Score = 156 bits (379), Expect = 3e-37
Identities = 74/183 (40%), Positives = 113/183 (61%), Gaps = 2/183 (1%)
Query: 2 SPKIILLFSGKRKSGKDFLTDHLRHIL-ADKCEIIKISQPIKTHWAXXXXXXXXXXXSEG 60
+P+++LLFSGKRKSGKDF+T+ L+ L AD C ++++S P+K +A
Sbjct: 7 APRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTS 66
Query: 61 EYKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDI 120
YKE +R +MI+W EE R D G FC+ E + +P+W+VSD RR +DI+WF+E YG +
Sbjct: 67 TYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGIS-QPIWLVSDTRRVSDIQWFREAYGAV 125
Query: 121 IRTVRITADDRTRKERGFQFQVGVDDATSECXXXXXXXXXXXXXXGEGRDSLEEQLDSIL 180
+TVR+ A +++R++RG+ F GVDDA SEC LEEQL++++
Sbjct: 126 TQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLI 185
Query: 181 KLV 183
+ +
Sbjct: 186 EFI 188
>UniRef50_Q9VIT2 Cluster: Probable phosphomevalonate kinase; n=6;
Diptera|Rep: Probable phosphomevalonate kinase -
Drosophila melanogaster (Fruit fly)
Length = 189
Score = 150 bits (364), Expect = 2e-35
Identities = 70/150 (46%), Positives = 99/150 (66%), Gaps = 4/150 (2%)
Query: 6 ILLFSGKRKSGKDFLTDHLRHILADKCEIIKISQPIKTHWAXXXXXXXXXXXSEGEYKEQ 65
I+L SGKRK GKD++++ L+ L + I++IS+PIK+ WA +G YKE+
Sbjct: 4 IVLISGKRKCGKDYISERLQRRLGSRSCIVRISEPIKSEWARKLQLDLDALLGDGPYKEK 63
Query: 66 YRLEMIKWSEEMRNKDYGCFCKAACENAAIK---PVWIVSDIRRKTDIRWFKETYG-DII 121
YR +MI WS+E+R +DYG FC+ A E A + P +VSD+RRK DIRWF+ETYG + +
Sbjct: 64 YRRDMIVWSDEVRAQDYGYFCRVAMEEALSRQQTPYILVSDVRRKNDIRWFRETYGPERV 123
Query: 122 RTVRITADDRTRKERGFQFQVGVDDATSEC 151
T+R+T+ TR RG+ F G+DD SEC
Sbjct: 124 ITLRLTSRPETRSARGWTFTAGIDDVPSEC 153
>UniRef50_Q3KPY7 Cluster: MGC131201 protein; n=1; Xenopus
laevis|Rep: MGC131201 protein - Xenopus laevis (African
clawed frog)
Length = 145
Score = 134 bits (324), Expect = 1e-30
Identities = 59/142 (41%), Positives = 92/142 (64%), Gaps = 2/142 (1%)
Query: 3 PKIILLFSGKRKSGKDFLTDHLR-HILADKCEIIKISQPIKTHWAXXXXXXXXXXXSEGE 61
P+++LLFSGKRKSGKD +T+ L+ +D C ++++S P+K +A
Sbjct: 4 PRLVLLFSGKRKSGKDHVTNSLQLRFSSDTCSVLRLSGPLKEQFALERGLDYERLLGATG 63
Query: 62 YKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDII 121
YKE++R +MI+W EE R +D G FC+ + + +PVWI+SD RRK+DI WF+ YG ++
Sbjct: 64 YKEEFRADMIRWGEEKRRRDPGFFCRIIVQRVS-QPVWIISDARRKSDIDWFRSEYGAVL 122
Query: 122 RTVRITADDRTRKERGFQFQVG 143
+TVR+ A + TR+ RG+ + G
Sbjct: 123 QTVRVEASEETREARGWVYTPG 144
>UniRef50_A7RZW5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 192
Score = 126 bits (303), Expect = 4e-28
Identities = 69/184 (37%), Positives = 100/184 (54%), Gaps = 9/184 (4%)
Query: 3 PKIILLFSGKRKSGKDFLTDHLRHILA-DKCEIIKISQPIKTHWAXXXXXXXXXXXSEGE 61
P + + SGKRKSGKD++ + L+ +L CEI+++S P+K +A +
Sbjct: 5 PFAVCILSGKRKSGKDYVAERLKILLGKSNCEILRLSGPLKREYARIHKLDYQKLLDSSD 64
Query: 62 YKEQYRLEMIKWSEEMRNKDYGCFCKAACENA------AIKPVWIVSDIRRKTDIRWFKE 115
YKE+YR +MIKW EE RN + FC+ A + A K W+VSD RR TD+++F++
Sbjct: 65 YKEKYRKDMIKWGEEKRNAEPYYFCELAAKMAYRDAQSETKLYWLVSDARRITDLQFFQQ 124
Query: 116 TYGDIIRTVRITADDRTRKERGFQFQVGVDDATSECXXXXXXXXXXXXXXGEGRDSLEEQ 175
Y ++ VR+TA D R RG+ F GVDDA SEC G+ + LE
Sbjct: 125 HYPRVVH-VRVTASDDVRMRRGWMFTNGVDDAESECGLDDVIFDVAIINNGD-NEQLENS 182
Query: 176 LDSI 179
L S+
Sbjct: 183 LASL 186
>UniRef50_Q86NH2 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 187
Score = 125 bits (302), Expect = 6e-28
Identities = 63/150 (42%), Positives = 87/150 (58%), Gaps = 5/150 (3%)
Query: 5 IILLFSGKRKSGKDFLTDHLRHILADK---CEIIKISQPIKTHWAXXXXXXXXXXXSEGE 61
I++ SGKRKSGKD+ T+ +R +L K + IS +K +A ++G
Sbjct: 3 IVIAISGKRKSGKDYCTNLIREVLVQKRFDVSVAGISHSLKMEFAKKHGLKYEELLTDGP 62
Query: 62 YKEQYRLEMIKWSEEMRNKDYGCFCKAACENAAIKPVWIVSDIRRKTDIRWFKETYGDII 121
YKE YR +MI+W EE R KD G FC+AA + + I+SD RR+TD +F Y +
Sbjct: 63 YKELYRKDMIQWGEEARCKDSGLFCRAAISSTMDSDIVIISDCRRRTDYEYFSANYRTV- 121
Query: 122 RTVRITADDRTRKERGFQFQVGVDDATSEC 151
T+RI + RK+RG+QF GVDDA SEC
Sbjct: 122 -TIRIETSEEDRKQRGYQFVEGVDDAESEC 150
>UniRef50_Q5DCX3 Cluster: SJCHGC02790 protein; n=3; Schistosoma
japonicum|Rep: SJCHGC02790 protein - Schistosoma
japonicum (Blood fluke)
Length = 202
Score = 97.5 bits (232), Expect = 2e-19
Identities = 60/157 (38%), Positives = 86/157 (54%), Gaps = 10/157 (6%)
Query: 5 IILLFSGKRKSGKDFLTDHLRHILADK---CEIIKISQPIKTHWAXXXXXXXXXXXSEGE 61
I ++FSGKRKSGKD+ +HL ++L +++IS+PIK+++A S E
Sbjct: 7 ICVVFSGKRKSGKDYTVNHLTNLLQSNHLSYLVVRISEPIKSYFAEHYGLNLSELLSSNE 66
Query: 62 YKEQYRLEMIKWSE-EMRNKDYGCFCKAACENA-----AIKPVWIVSDIRRKTDIRWFKE 115
YKE YR +MI W E E++ Y K+ E+ + V I+SD RR DI + +
Sbjct: 67 YKENYRKQMISWMEQEIKQDPYVFIRKSLLESTRRHGISQPAVIIISDARRVNDIEYLIK 126
Query: 116 TYG-DIIRTVRITADDRTRKERGFQFQVGVDDATSEC 151
T+G VRI A R ERG+ + GVD+A SEC
Sbjct: 127 TFGRSKCLLVRIVAPIEIRTERGWTYVNGVDNAASEC 163
>UniRef50_Q2GYY3 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 1109
Score = 35.5 bits (78), Expect = 0.77
Identities = 19/70 (27%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 1 MSPKIILLFSGKRKSGKDFLTDHLRHILAD---KCEIIKISQPIKTHWAXXXXXXXXXXX 57
M PK+I+L +G+ +GKD+ D + + + + IS K +A
Sbjct: 716 MEPKLIVLVTGEHGAGKDYCADLWVEFFNNNKFRAQAVSISDATKREYASATGANLDRLF 775
Query: 58 SEGEYKEQYR 67
+ YKEQ+R
Sbjct: 776 QDRAYKEQHR 785
>UniRef50_A1DPA3 Cluster: Ferric-chelate reductase, putative; n=3;
Trichocomaceae|Rep: Ferric-chelate reductase, putative -
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
3700 / NRRL 181))
Length = 653
Score = 33.9 bits (74), Expect = 2.3
Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 3/45 (6%)
Query: 89 ACENAAIKPVWIVSDIRRKTDIRWFKETYGDIIRTVRITADDRTR 133
AC +A I+ +W+ IRRK D+ W K ++ + A+ R R
Sbjct: 483 ACRSALIEFIWV---IRRKADMEWLKSEMDALVAAAEVCANFRIR 524
>UniRef50_Q0UBI2 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 1627
Score = 32.3 bits (70), Expect = 7.2
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 10/76 (13%)
Query: 3 PKIILLFSGKRKSGKDF--------LTDHLRHILADKCEIIKISQPIKTHWAXXXXXXXX 54
PK+I L +G +GKD+ + DH R L + I IS K +A
Sbjct: 698 PKLIFLVTGNHGAGKDYCAEQWASEVKDHARERL--EVHISSISDATKRAYAASTGADLA 755
Query: 55 XXXSEGEYKEQYRLEM 70
++ YKEQ+R M
Sbjct: 756 RLLNDRAYKEQHRAAM 771
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.320 0.136 0.416
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 178,162,224
Number of Sequences: 1657284
Number of extensions: 5964421
Number of successful extensions: 9673
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 9642
Number of HSP's gapped (non-prelim): 12
length of query: 186
length of database: 575,637,011
effective HSP length: 96
effective length of query: 90
effective length of database: 416,537,747
effective search space: 37488397230
effective search space used: 37488397230
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 69 (31.9 bits)
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