Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001548-TA|BGIBMGA001548-PA|IPR000980|SH2 motif,
IPR001245|Tyrosine protein kinase, IPR000719|Protein kinase,
IPR008266|Tyrosine protein kinase, active site, IPR011009|Protein
kinase-like
(514 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 350 6e-95
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 349 1e-94
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 313 6e-84
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 285 3e-75
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 257 4e-67
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 256 1e-66
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 256 1e-66
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 251 3e-65
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 237 7e-61
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 236 1e-60
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 235 3e-60
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 227 4e-58
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 227 5e-58
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 225 3e-57
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 224 4e-57
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 223 1e-56
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 220 6e-56
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 219 2e-55
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 216 1e-54
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 216 1e-54
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 212 2e-53
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 211 3e-53
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 211 3e-53
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 208 2e-52
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 207 6e-52
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 206 8e-52
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 206 1e-51
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 203 1e-50
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 201 3e-50
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 200 5e-50
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 198 3e-49
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 195 2e-48
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 194 4e-48
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 194 4e-48
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 194 6e-48
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 193 1e-47
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 192 2e-47
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 192 2e-47
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 192 2e-47
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 191 3e-47
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 191 3e-47
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 190 1e-46
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 189 1e-46
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 189 2e-46
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 188 2e-46
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 188 4e-46
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 186 9e-46
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 185 2e-45
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 185 2e-45
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 185 3e-45
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 183 9e-45
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 182 2e-44
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 182 2e-44
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 182 2e-44
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 182 2e-44
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 182 2e-44
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 181 4e-44
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 181 5e-44
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 181 5e-44
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 180 6e-44
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 180 6e-44
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 180 8e-44
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 180 8e-44
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 179 1e-43
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 179 2e-43
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 178 3e-43
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 178 3e-43
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 177 4e-43
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 177 4e-43
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 177 6e-43
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 177 6e-43
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 177 8e-43
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 177 8e-43
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 176 1e-42
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 176 1e-42
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 176 1e-42
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 176 1e-42
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 175 2e-42
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 175 2e-42
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 175 2e-42
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 175 2e-42
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 175 3e-42
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 175 3e-42
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 175 3e-42
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 175 3e-42
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 174 4e-42
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 174 4e-42
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 174 4e-42
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 174 4e-42
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 174 4e-42
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 174 4e-42
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 174 4e-42
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 174 5e-42
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 174 5e-42
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 174 5e-42
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 174 5e-42
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 173 7e-42
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 173 7e-42
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 173 7e-42
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 173 7e-42
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 173 9e-42
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 173 9e-42
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 173 1e-41
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 172 2e-41
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 172 2e-41
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 172 2e-41
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 172 2e-41
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 172 2e-41
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 172 2e-41
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 172 2e-41
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 171 3e-41
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 171 4e-41
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 171 4e-41
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 171 4e-41
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 171 4e-41
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 171 5e-41
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 171 5e-41
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 171 5e-41
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 171 5e-41
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 171 5e-41
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 171 5e-41
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 170 7e-41
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 170 7e-41
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 170 7e-41
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 170 7e-41
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 170 9e-41
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 170 9e-41
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 169 1e-40
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 169 1e-40
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 169 1e-40
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 169 1e-40
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 169 1e-40
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 169 2e-40
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 169 2e-40
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 169 2e-40
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 169 2e-40
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 169 2e-40
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 168 3e-40
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 168 3e-40
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 168 3e-40
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 168 3e-40
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 168 4e-40
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 168 4e-40
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 167 5e-40
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 167 8e-40
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 166 1e-39
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 166 1e-39
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 166 1e-39
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 165 2e-39
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 165 2e-39
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 165 2e-39
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 165 2e-39
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 165 3e-39
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 165 3e-39
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 164 4e-39
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 164 4e-39
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 164 6e-39
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 164 6e-39
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 164 6e-39
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 163 1e-38
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 162 2e-38
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 162 2e-38
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 162 2e-38
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 162 2e-38
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 162 2e-38
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 161 3e-38
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 161 3e-38
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 161 3e-38
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 161 4e-38
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 161 4e-38
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 161 5e-38
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 161 5e-38
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 161 5e-38
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 161 5e-38
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 161 5e-38
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 160 7e-38
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 160 7e-38
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 160 7e-38
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 160 7e-38
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 160 9e-38
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 160 9e-38
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 159 1e-37
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 159 2e-37
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 159 2e-37
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 158 3e-37
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 158 3e-37
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 158 3e-37
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 158 4e-37
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 158 4e-37
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 158 4e-37
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 158 4e-37
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 157 5e-37
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 157 5e-37
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 157 9e-37
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 157 9e-37
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 157 9e-37
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 157 9e-37
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 156 1e-36
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 156 1e-36
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 156 1e-36
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 156 1e-36
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 156 1e-36
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 156 2e-36
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 156 2e-36
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 155 2e-36
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 155 2e-36
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 155 2e-36
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 155 2e-36
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 155 2e-36
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 155 3e-36
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 155 3e-36
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 155 3e-36
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 155 3e-36
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 155 3e-36
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 155 3e-36
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 154 5e-36
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 154 5e-36
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 154 5e-36
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 154 5e-36
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 154 5e-36
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 154 5e-36
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 154 5e-36
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 154 5e-36
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 154 6e-36
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 154 6e-36
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 154 6e-36
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 154 6e-36
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 153 8e-36
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 153 8e-36
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 153 1e-35
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 153 1e-35
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 153 1e-35
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 153 1e-35
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 153 1e-35
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 152 2e-35
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 152 2e-35
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 152 2e-35
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 152 2e-35
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 152 2e-35
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 152 2e-35
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 152 2e-35
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 151 3e-35
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 151 3e-35
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 151 3e-35
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 151 4e-35
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 151 4e-35
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 151 4e-35
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 151 4e-35
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 151 6e-35
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 151 6e-35
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 151 6e-35
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 150 1e-34
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 150 1e-34
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 150 1e-34
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 150 1e-34
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 150 1e-34
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 150 1e-34
UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine k... 149 2e-34
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 149 2e-34
UniRef50_Q6W5B1 Cluster: TEL/JAK2 fusion protein; n=4; Danio rer... 149 2e-34
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 149 2e-34
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 149 2e-34
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 149 2e-34
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 149 2e-34
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 149 2e-34
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 148 3e-34
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 148 4e-34
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 148 4e-34
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 148 4e-34
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 147 7e-34
UniRef50_Q61B52 Cluster: Putative uncharacterized protein CBG134... 147 7e-34
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 147 7e-34
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 146 9e-34
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 146 9e-34
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 146 9e-34
UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep: EDR1... 146 1e-33
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 146 1e-33
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 146 2e-33
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 146 2e-33
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 146 2e-33
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 145 2e-33
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 145 2e-33
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 145 2e-33
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 145 2e-33
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 145 3e-33
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 145 3e-33
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 144 4e-33
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 144 4e-33
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 144 5e-33
UniRef50_Q24592 Cluster: Tyrosine-protein kinase hopscotch; n=2;... 144 5e-33
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 144 5e-33
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 144 7e-33
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 144 7e-33
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 144 7e-33
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 144 7e-33
UniRef50_Q19726 Cluster: Putative uncharacterized protein kin-14... 144 7e-33
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 143 9e-33
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 143 9e-33
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 143 9e-33
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 143 1e-32
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 142 2e-32
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 142 2e-32
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 142 2e-32
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 142 2e-32
UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677; ... 142 2e-32
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 142 2e-32
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 142 2e-32
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 141 3e-32
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 141 5e-32
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 141 5e-32
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 140 8e-32
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 140 8e-32
UniRef50_UPI000065E468 Cluster: Homolog of Gallus gallus "Ephrin... 140 1e-31
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 139 1e-31
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 139 1e-31
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 139 1e-31
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 139 1e-31
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 139 2e-31
UniRef50_Q9LMF8 Cluster: F16A14.22; n=9; Magnoliophyta|Rep: F16A... 139 2e-31
UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1; Trichom... 139 2e-31
UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core eu... 138 2e-31
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 138 2e-31
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 138 2e-31
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 138 3e-31
UniRef50_Q4S5N1 Cluster: Chromosome 9 SCAF14729, whole genome sh... 138 3e-31
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 138 3e-31
UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein;... 138 4e-31
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 138 4e-31
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 137 6e-31
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 137 6e-31
UniRef50_Q4RX00 Cluster: Chromosome 11 SCAF14979, whole genome s... 137 6e-31
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 137 6e-31
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 137 6e-31
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 137 8e-31
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 137 8e-31
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 137 8e-31
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 136 1e-30
UniRef50_UPI0000499A85 Cluster: protein kinase; n=1; Entamoeba h... 136 1e-30
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 136 1e-30
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 136 1e-30
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 136 1e-30
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 136 1e-30
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 136 2e-30
UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;... 136 2e-30
UniRef50_A2E4G1 Cluster: TKL family protein kinase; n=1; Trichom... 136 2e-30
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 136 2e-30
UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated ... 135 2e-30
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 135 2e-30
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 135 3e-30
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 135 3e-30
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 135 3e-30
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 135 3e-30
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 134 4e-30
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 134 5e-30
UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1; Trichom... 134 5e-30
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 134 7e-30
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 134 7e-30
UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase... 134 7e-30
UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1; n... 134 7e-30
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 133 9e-30
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 133 1e-29
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 133 1e-29
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 133 1e-29
UniRef50_Q9PTN6 Cluster: Tyrosine-protein kinase; n=9; Euteleost... 132 2e-29
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 132 2e-29
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 132 2e-29
UniRef50_Q9GZG1 Cluster: Putative uncharacterized protein; n=6; ... 132 2e-29
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 132 2e-29
UniRef50_O01325 Cluster: Putative uncharacterized protein; n=2; ... 132 2e-29
UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genom... 132 3e-29
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 132 3e-29
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 132 3e-29
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 132 3e-29
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 131 4e-29
UniRef50_Q4RU24 Cluster: Chromosome 12 SCAF14996, whole genome s... 131 4e-29
UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2; ... 131 4e-29
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 131 4e-29
UniRef50_A2DZZ0 Cluster: TKL family protein kinase; n=1; Trichom... 131 4e-29
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 131 4e-29
UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole gen... 130 7e-29
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 130 7e-29
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 130 7e-29
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 130 7e-29
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 130 7e-29
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 130 9e-29
UniRef50_O43283 Cluster: Mitogen-activated protein kinase kinase... 130 9e-29
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 130 1e-28
UniRef50_Q0IZJ5 Cluster: Os09g0566500 protein; n=9; Magnoliophyt... 130 1e-28
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 130 1e-28
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 130 1e-28
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 130 1e-28
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 129 2e-28
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 129 2e-28
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 129 2e-28
UniRef50_Q23102 Cluster: Putative uncharacterized protein; n=1; ... 129 2e-28
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 128 3e-28
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 128 3e-28
UniRef50_Q23927 Cluster: Protein tyrosine kinase; n=3; Dictyoste... 128 3e-28
UniRef50_A2DH69 Cluster: TKL family protein kinase; n=1; Trichom... 128 3e-28
UniRef50_O12990 Cluster: Tyrosine-protein kinase Jak1; n=8; Eute... 128 3e-28
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 128 3e-28
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 128 3e-28
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 128 5e-28
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 127 6e-28
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 127 6e-28
UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor p... 127 6e-28
UniRef50_Q6GPK5 Cluster: Tyrosine-protein kinase; n=4; Euteleost... 127 8e-28
UniRef50_Q55A09 Cluster: Kelch repeat-containing protein; n=4; D... 127 8e-28
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 127 8e-28
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 127 8e-28
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 127 8e-28
UniRef50_Q94AB2 Cluster: AT3g58640/F14P22_230; n=13; Magnoliophy... 126 1e-27
UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,... 126 1e-27
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 126 1e-27
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 126 1e-27
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 126 2e-27
UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (E... 125 2e-27
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 125 2e-27
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 125 2e-27
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 125 2e-27
UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole gen... 125 2e-27
UniRef50_A7NXT1 Cluster: Chromosome chr5 scaffold_2, whole genom... 125 2e-27
UniRef50_UPI0000E49042 Cluster: PREDICTED: similar to RE05926p; ... 125 3e-27
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 125 3e-27
UniRef50_Q4T1R9 Cluster: Chromosome 4 SCAF10492, whole genome sh... 125 3e-27
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 125 3e-27
UniRef50_Q9LYI8 Cluster: MAP3K delta-1 protein kinase; n=3; Arab... 124 4e-27
UniRef50_Q9FGZ6 Cluster: Protein kinase; n=3; Arabidopsis thalia... 124 4e-27
UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Tritic... 124 4e-27
UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole gen... 124 4e-27
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 124 6e-27
UniRef50_P91360 Cluster: Putative uncharacterized protein; n=1; ... 124 6e-27
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 124 6e-27
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 124 7e-27
UniRef50_Q9NYL2 Cluster: Mitogen-activated protein kinase kinase... 123 1e-26
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 123 1e-26
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 123 1e-26
UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum lycopersicu... 123 1e-26
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 123 1e-26
UniRef50_A2FUX6 Cluster: TKL family protein kinase; n=1; Trichom... 123 1e-26
UniRef50_A2FG05 Cluster: TKL family protein kinase; n=1; Trichom... 123 1e-26
UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31... 123 1e-26
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 122 2e-26
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 122 2e-26
UniRef50_Q9C547 Cluster: Protein kinase, putative; 12576-15979; ... 122 2e-26
UniRef50_Q5XTZ4 Cluster: Salt-inducible protein kinase; n=2; Poa... 122 2e-26
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 122 2e-26
UniRef50_A2FCV2 Cluster: TKL family protein kinase; n=1; Trichom... 122 2e-26
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 122 2e-26
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 122 2e-26
UniRef50_Q6ER39 Cluster: CTR1-like kinase kinase kinase-like; n=... 122 2e-26
UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1; Dictyos... 122 2e-26
UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1; Dictyos... 122 2e-26
UniRef50_UPI00015B628A Cluster: PREDICTED: similar to LD14856p; ... 122 3e-26
UniRef50_UPI0000DB7B8A Cluster: PREDICTED: similar to CG8789-PA,... 122 3e-26
UniRef50_UPI0000519EF1 Cluster: PREDICTED: similar to CG31640-PA... 122 3e-26
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 122 3e-26
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 122 3e-26
UniRef50_A7Q6K4 Cluster: Chromosome chr11 scaffold_56, whole gen... 122 3e-26
UniRef50_Q61CN6 Cluster: Putative uncharacterized protein CBG128... 122 3e-26
UniRef50_Q5CVX5 Cluster: Ser/Thr protein kinase with MORN repeat... 122 3e-26
UniRef50_Q18865 Cluster: Putative uncharacterized protein; n=5; ... 122 3e-26
UniRef50_A2EY26 Cluster: TKL family protein kinase; n=2; Trichom... 122 3e-26
UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to mitogen-ac... 121 4e-26
UniRef50_UPI0000585FA7 Cluster: PREDICTED: similar to leucine zi... 121 4e-26
UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Or... 121 4e-26
UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=... 121 4e-26
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 121 4e-26
UniRef50_Q9ZSD8 Cluster: Ethylene-inducible CTR1-like protein ki... 121 5e-26
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 121 5e-26
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 120 7e-26
UniRef50_Q5W6K6 Cluster: Kinase domain containing protein; n=2; ... 120 7e-26
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 120 7e-26
UniRef50_UPI0000F202EE Cluster: PREDICTED: similar to LCK2; n=2;... 120 9e-26
UniRef50_UPI000049A16F Cluster: protein kinase; n=1; Entamoeba h... 120 9e-26
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 120 9e-26
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 120 9e-26
UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:... 120 9e-26
UniRef50_Q0DE32 Cluster: Os06g0181200 protein; n=5; Oryza sativa... 120 9e-26
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 120 9e-26
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 120 9e-26
UniRef50_A7QMH3 Cluster: Chromosome chr19 scaffold_126, whole ge... 120 1e-25
UniRef50_Q9VW24 Cluster: CG8789-PA, isoform A; n=3; Diptera|Rep:... 120 1e-25
UniRef50_Q22765 Cluster: Putative uncharacterized protein; n=3; ... 120 1e-25
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 120 1e-25
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 120 1e-25
UniRef50_Q9STG4 Cluster: Putative uncharacterized protein T6H20.... 119 2e-25
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 119 2e-25
UniRef50_Q9TYX4 Cluster: Putative uncharacterized protein R11E3.... 119 2e-25
UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gamb... 119 2e-25
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 119 2e-25
UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;... 119 2e-25
UniRef50_O64768 Cluster: Putative uncharacterized protein At2g35... 119 2e-25
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 119 2e-25
UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 119 2e-25
UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1; Trichom... 119 2e-25
UniRef50_Q98TP5 Cluster: C-Src protein-tyrosine kinase; n=5; Eut... 118 3e-25
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 118 4e-25
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 118 4e-25
UniRef50_A7RWY4 Cluster: Predicted protein; n=1; Nematostella ve... 118 4e-25
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 350 bits (860), Expect = 6e-95
Identities = 173/276 (62%), Positives = 207/276 (75%), Gaps = 10/276 (3%)
Query: 217 QSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDR-EAASKFRAEAS 275
+ F D W+I DL+++ENIGKGEFGDVMLGIL G +KVAVK+LKD A++KF AEA
Sbjct: 475 KDFQDNGWEIKMEDLQLKENIGKGEFGDVMLGILKG-EKVAVKVLKDAGRASNKFLAEAG 533
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
VM +L+HENLV+ +GLVF LVTE+ ++GSL+DYLRSRGR ++T+ +QINFAFD
Sbjct: 534 VMTTLEHENLVKFIGLVFHDKY-IYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDT 592
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
C GMEYLE ++V+HRDLAARNVLIS E AKV+DFG +KLPIK
Sbjct: 593 CSGMEYLEMKKVIHRDLAARNVLISEECVAKVSDFGLARDERYTADI-------SKLPIK 645
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
WTAPEALK KFSNK+DMWSFGILLWEIYSFGRVPYPRIPLA+VV+HV GY+MEAPEGC
Sbjct: 646 WTAPEALKEGKFSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVGSGYKMEAPEGC 705
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
PP YE+MR AW P RPTF ++R LA + T
Sbjct: 706 PPEIYEMMRQAWDLVPEKRPTFAELKRRLAVCKRET 741
Score = 132 bits (320), Expect = 2e-29
Identities = 60/99 (60%), Positives = 73/99 (73%), Gaps = 6/99 (6%)
Query: 57 PWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQ 116
PW HG I RE AE LL DG+FLVRESTNFPGD+TLCV F +VEHYR+K+A
Sbjct: 377 PWFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYA------ 430
Query: 117 NQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+LTIDD+E+FDN+ L+ HY D+DGLCTKL++ LPK
Sbjct: 431 ENKLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPK 469
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 349 bits (858), Expect = 1e-94
Identities = 173/278 (62%), Positives = 209/278 (75%), Gaps = 9/278 (3%)
Query: 214 LQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASKFRAE 273
+ S+ FVD W I E +L++RE+IGKGEFGDVMLGIL +KVAVK+LKD A KF AE
Sbjct: 578 INSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRN-EKVAVKMLKDEGAVQKFLAE 636
Query: 274 ASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAF 333
ASVM +L+H+NLV+ +GLVFTS LVTE+ ++GSL+DYLRSRGR ++T+ +QI FA+
Sbjct: 637 ASVMTTLEHDNLVKFIGLVFTSKH-LYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAY 695
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
D GMEYLE ++VVHRDLAARNVLIS + AKV+DFG KLP
Sbjct: 696 DTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDV-------GKLP 748
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
IKWTAPEALK +FSNKSDMWSFGILLWEIYSFGRVPYPRIPLA+VV+HVE GY+MEAPE
Sbjct: 749 IKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPE 808
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
GCPP YE+MR AW +PA RPTF ++ L + + T
Sbjct: 809 GCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 846
Score = 136 bits (329), Expect = 1e-30
Identities = 61/105 (58%), Positives = 78/105 (74%), Gaps = 6/105 (5%)
Query: 51 VNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWA 110
V + PW HG+I+R+ AE LL DG+FLVRESTNFPGD+TLCV F+ +VEHYRVK+
Sbjct: 472 VKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL 531
Query: 111 TAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+LTIDDEE+F+N+ L+ HY DADGLCT+L++CLPK
Sbjct: 532 ------ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPK 570
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 313 bits (769), Expect = 6e-84
Identities = 152/281 (54%), Positives = 192/281 (68%), Gaps = 9/281 (3%)
Query: 211 DGTLQSQS-FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK 269
+GT+ +Q F + W ++ ++L++ + IGKGEFGDVMLG G KVAVK +K+ A
Sbjct: 174 EGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA 232
Query: 270 FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI 329
F AEASVM L+H NLV+LLG++ GG +VTE+ A+GSL+DYLRSRGR + +
Sbjct: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292
Query: 330 NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ 389
F+ D C MEYLE VHRDLAARNVL+S + AKV+DFG
Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT------- 345
Query: 390 AKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRM 449
KLP+KWTAPEAL+ KFS KSD+WSFGILLWEIYSFGRVPYPRIPL +VV VE+GY+M
Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405
Query: 450 EAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
+AP+GCPP YE+M+ WH D A RP+FL +R L I+ H
Sbjct: 406 DAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 446
Score = 114 bits (274), Expect = 6e-24
Identities = 54/106 (50%), Positives = 74/106 (69%), Gaps = 9/106 (8%)
Query: 46 AGNRLVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHY 105
AG +L M PW HG I+RE+AE LL G+FLVRESTN+PGD+TLCV G+VEHY
Sbjct: 73 AGTKLSLM---PWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHY 129
Query: 106 RVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVR 151
R+ + + +L+ID+E +F+N+ L+ HY DADGLCT+L++
Sbjct: 130 RIMYHAS------KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIK 169
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 285 bits (698), Expect = 3e-75
Identities = 146/290 (50%), Positives = 187/290 (64%), Gaps = 12/290 (4%)
Query: 202 APAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKI- 260
AP Q + F + W I + L + IGKGEFG+V LG G +KVA+K
Sbjct: 197 APVDKEGQHLFVVDVNDFKEKGWAIPKASLLKKSLIGKGEFGEVWLGDYEG-KKVAMKSM 255
Query: 261 ---LKDREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS 317
LKD +A ++F AEASVM +L+H NLV L+G+ + L+TE A+GSL+DYLRS
Sbjct: 256 KDHLKDEKAKTQFLAEASVMTTLRHPNLVCLIGISLDDNP-IYLITEFMAKGSLIDYLRS 314
Query: 318 RGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
RGR +T+ NQI+FA D GM YLE Q VHRDLAARNVLI+ + AKV+DFG
Sbjct: 315 RGRAVITKQNQIDFARDVVKGMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAKSSS 374
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
AKLP+KWTAPEAL+ NKFSNK+D+WSFG+LLWEIYS+GRVPYPR+P+
Sbjct: 375 NVKQEG------AKLPVKWTAPEALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVE 428
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
+V HVE GYRME+P+GCP Y++M W DP+ RP F + + L +
Sbjct: 429 DVANHVENGYRMESPDGCPDQIYKIMMDCWEKDPSQRPNFTRIEKALESV 478
Score = 116 bits (280), Expect = 1e-24
Identities = 54/104 (51%), Positives = 72/104 (69%), Gaps = 5/104 (4%)
Query: 46 AGNRLVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHY 105
A V + PW HG ISRE AE LL+ +G FLVRES N+PGD+TLCV + GRVE+Y
Sbjct: 97 ASKGAVQLKTMPWFHGRISREDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENY 156
Query: 106 RVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
RV+ N+ +T+DD+E+FDN+ L+ HY ++ADGLCT+L
Sbjct: 157 RVR-----RNEKGLVTVDDDEYFDNLIKLVEHYQKEADGLCTRL 195
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 257 bits (630), Expect = 4e-67
Identities = 130/279 (46%), Positives = 173/279 (62%), Gaps = 10/279 (3%)
Query: 207 TDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKD-RE 265
T+ + +SF W + D+E +E IGKGEFG+V G+ + VA+K L+D +
Sbjct: 189 TEILQSAIFKESFQKEGWAVPIEDVEFKELIGKGEFGNVYKGVW-AKKTVAIKKLRDDSK 247
Query: 266 AASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQ 325
A AEASVM +L+H+NLV L+ + F ++TE+C +G L++YLR+RGR +T
Sbjct: 248 TAQSLLAEASVMTTLQHKNLVVLVAISFQGDS-ILILTEYCEKGVLVEYLRTRGRAVITL 306
Query: 326 LNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXX 385
Q FA D C GM YLE + ++HRDLAARNVL+S E AKV+DFG
Sbjct: 307 EEQKGFAIDVCNGMRYLEEKNIIHRDLAARNVLLSDELCAKVSDFGLAKDVEQELAS--- 363
Query: 386 XXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER 445
K P+KWTAPEA++ FS KSD+WSFGILLWEI+SFGR PYPR PL E++ ++
Sbjct: 364 ----GKFPVKWTAPEAIELKIFSTKSDVWSFGILLWEIFSFGRNPYPREPLDELLTKIKS 419
Query: 446 GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
YRME PE CPP Y+LM W ADP+ RP+F + L
Sbjct: 420 NYRMECPEKCPPFVYQLMLKCWDADPSRRPSFKQLHNEL 458
Score = 107 bits (257), Expect = 7e-22
Identities = 56/110 (50%), Positives = 75/110 (68%), Gaps = 8/110 (7%)
Query: 49 RLVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCV---RFRGRVEHY 105
R +++ + PW G I+RE+AE LL+ G+FLVRESTNFPGD+TLCV + +VEHY
Sbjct: 83 RALHLHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHY 142
Query: 106 RVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
RV + DNQ +T+D+E FF + +LI HY +DADGLCT L + L K
Sbjct: 143 RV--ISTSDNQ---VTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKK 187
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 256 bits (627), Expect = 1e-66
Identities = 131/286 (45%), Positives = 176/286 (61%), Gaps = 8/286 (2%)
Query: 206 STDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK--D 263
S+ D ++ F A I D+++ + IG GEFGDV LG +KVA+K+ K
Sbjct: 258 SSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKN-RKVALKVSKRHG 316
Query: 264 REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYV 323
EA M L H NLV L+G+V ++TE+ A G+L+D LRSRGRH +
Sbjct: 317 NGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVN-VYMITEYMANGNLIDLLRSRGRHAL 375
Query: 324 TQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXX 383
+ + FA D C GM YLE +++VHRDLAARNVL+ + AKV+DFG
Sbjct: 376 ERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDS 435
Query: 384 XXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHV 443
K PIKWTAPEAL++++F+ KSD+WSFGILLWEI+SFGRVPYPRIP+ +VVR++
Sbjct: 436 AS----GKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYI 491
Query: 444 ERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
E+GYRMEAPEGCPP +++M W RP+F + + L IR+
Sbjct: 492 EKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRN 537
Score = 122 bits (294), Expect = 2e-26
Identities = 55/94 (58%), Positives = 65/94 (69%), Gaps = 5/94 (5%)
Query: 57 PWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQ 116
PW H ISRE E LL G PDG FLVRESTNFPGD TLC+ F G+VEHYR++
Sbjct: 150 PWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIE-----QTS 204
Query: 117 NQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
+LT D EE+F N+T L+ HY +DADGLC +LV
Sbjct: 205 GGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLV 238
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 256 bits (627), Expect = 1e-66
Identities = 132/278 (47%), Positives = 174/278 (62%), Gaps = 13/278 (4%)
Query: 214 LQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKD--REAASKFR 271
+ ++ FV+ W+I R++ IG G+FGDV G+ G QKVA+K LKD +A +F
Sbjct: 200 IDARKFVN--WEISPREIVKSAQIGSGQFGDVFEGLYRG-QKVAIKTLKDVQGDAIDQFL 256
Query: 272 AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINF 331
EA M L+H+NLV+L+G V T +V+E +G LLDYLRSRGR + Q+ F
Sbjct: 257 LEADTMTRLRHKNLVQLIG-VCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGF 315
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
D C MEYLE Q+ VHRDLAARN+L+S +G AKVADFG K
Sbjct: 316 CRDICAAMEYLEEQKFVHRDLAARNILLSDDGVAKVADFGLAKDSQLGVTDI------GK 369
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEA 451
LPIKWTAPEA++ ++KSD+WSFG++LWEI++FGR PYPR+ EVV V +GYRME
Sbjct: 370 LPIKWTAPEAIRLKVSTSKSDVWSFGVVLWEIFAFGRAPYPRMGQKEVVDAVVKGYRMEC 429
Query: 452 PEGCPPGPYE-LMRAAWHADPASRPTFLHMRRNLADIR 488
P+ CP Y+ +M A W DP RPTF + R L+ I+
Sbjct: 430 PDTCPKEVYDKIMMACWEIDPVKRPTFKTLMRALSSIQ 467
Score = 114 bits (275), Expect = 5e-24
Identities = 55/107 (51%), Positives = 76/107 (71%), Gaps = 9/107 (8%)
Query: 43 PPPAGNRLVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRV 102
P A +L+ M PW HG ISRE AE+LL DG+FLVRES +FPGD+TLCV F+ +V
Sbjct: 89 PRDASGQLIPM---PWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQV 145
Query: 103 EHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+HYR++ +N +LTID+E +F ++ +L+ HY +DADGLCT+L
Sbjct: 146 DHYRMQ------GKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTRL 186
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 251 bits (615), Expect = 3e-65
Identities = 125/264 (47%), Positives = 172/264 (65%), Gaps = 10/264 (3%)
Query: 222 ARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASKFRAEASVMASLK 281
A W ++ + L + IG+GEFG V+ G G QKVAVK +K A F E +VM ++
Sbjct: 226 AGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG-QKVAVKNIKCDVTAQAFLDETAVMTKMQ 284
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
HENLVRLLG++ G +V EH ++G+L+++LR+RGR V + F+ GMEY
Sbjct: 285 HENLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEY 342
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE +++VHRDLAARN+L+S + AKV+DFG ++LP+KWTAPEA
Sbjct: 343 LESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDS-------SRLPVKWTAPEA 395
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
LK+ KF++KSD+WSFG+LLWE++S+GR PYP++ L EV VE+GYRME PEGCP +
Sbjct: 396 LKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHV 455
Query: 462 LMRAAWHADPASRPTFLHMRRNLA 485
LM + W A+PA RP F + LA
Sbjct: 456 LMSSCWEAEPARRPPFRKLAEKLA 479
Score = 90.6 bits (215), Expect = 9e-17
Identities = 50/124 (40%), Positives = 69/124 (55%), Gaps = 7/124 (5%)
Query: 28 TKGQSDVLVNSSVQNPPPAGNRLVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTN 87
T GQ +L +++ A + ++ PW HG IS + A L DG+FLVRES
Sbjct: 93 TSGQEGLLAAGALRERE-ALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESAR 151
Query: 88 FPGDHTLCVRFRGRVEHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCT 147
PGD+ LCV F V HYRV +++ LTID+ FF N+ D++ HY +D +CT
Sbjct: 152 HPGDYVLCVSFGRDVIHYRVL------HRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICT 205
Query: 148 KLVR 151
KLVR
Sbjct: 206 KLVR 209
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 237 bits (579), Expect = 7e-61
Identities = 119/266 (44%), Positives = 158/266 (59%), Gaps = 6/266 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILKDREAASK-FRAEASVMASLK 281
W+I+ D+ +R +G G++GDV + VAVK LK+ A K F EA++M +K
Sbjct: 282 WEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKDFLEEAAIMKEMK 341
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H NLV+LLG V T ++TE ++G+LLDYLR+ +H + + ++ A GM Y
Sbjct: 342 HRNLVQLLG-VCTREPPFYIITEFMSKGNLLDYLRNESKHQINAVVLMHMATQIASGMSY 400
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE + +HRDLAARN L+ KVADFG AK PIKWTAPE
Sbjct: 401 LESRNFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAG---AKFPIKWTAPEG 457
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
L YNKFS KSD+W+FGILLWEI ++G PYP + L +V +E+GYRME P GCPP YE
Sbjct: 458 LAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPKVYE 517
Query: 462 LMRAAWHADPASRPTFLHMRRNLADI 487
LMR W A RPTF + +L ++
Sbjct: 518 LMRQCWQWSAADRPTFKEIHHSLENM 543
Score = 81.8 bits (193), Expect = 4e-14
Identities = 39/98 (39%), Positives = 59/98 (60%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG I R AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ ++
Sbjct: 174 WYHGRICRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN-----EDSE 228
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
++ + E F+ + +L+HH+ ADGL T+L+ PK
Sbjct: 229 GKMFVTTESKFNTLAELVHHHSMLADGLITQLLYPAPK 266
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 236 bits (577), Expect = 1e-60
Identities = 122/267 (45%), Positives = 162/267 (60%), Gaps = 6/267 (2%)
Query: 213 TLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILK-DREAASKF 270
T+ S + +W+++ D+ ++ +G G++G+V +G+ + VAVK LK D +F
Sbjct: 270 TVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEF 329
Query: 271 RAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQIN 330
EA+VM +KH NLV+LLG V T +VTE+ G+LLDYLR R VT + +
Sbjct: 330 LKEAAVMKEIKHPNLVQLLG-VCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLY 388
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQA 390
A MEYLE++ +HRDLAARN L+ KVADFG A
Sbjct: 389 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG---A 445
Query: 391 KLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRME 450
K PIKWTAPE+L YN FS KSD+W+FG+LLWEI ++G PYP I L++V +E+GYRME
Sbjct: 446 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 505
Query: 451 APEGCPPGPYELMRAAWHADPASRPTF 477
PEGCPP YELMRA W PA RP+F
Sbjct: 506 QPEGCPPKVYELMRACWKWSPADRPSF 532
Score = 77.8 bits (183), Expect = 6e-13
Identities = 41/98 (41%), Positives = 57/98 (58%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG +SR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ T D
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN--TTADG-- 228
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
++ + E F + +L+HH+ ADGL T L PK
Sbjct: 229 -KVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 265
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 235 bits (574), Expect = 3e-60
Identities = 117/266 (43%), Positives = 158/266 (59%), Gaps = 6/266 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILKDREAASK-FRAEASVMASLK 281
W+I+ D+ +R +G G++GDV + VAVK LK+ A K F EA++M +K
Sbjct: 283 WEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKDFLEEAAIMKEMK 342
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H NLV+L+G V T ++TE ++G+LLDYLR+ +H + + ++ A GM Y
Sbjct: 343 HRNLVQLIG-VCTREPPFYIITEFMSKGNLLDYLRNESKHQINAVVLMHMATQIASGMSY 401
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE + +HRDLAARN L+ KVADFG AK PIKWTAPE
Sbjct: 402 LESRNFIHRDLAARNCLVGESHLVKVADFGLARLMRDDTYTAHAG---AKFPIKWTAPEG 458
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
L YNKFS KSD+W+FGILLWEI ++G PYP + L +V +E+GYRME P GCPP YE
Sbjct: 459 LAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPKVYE 518
Query: 462 LMRAAWHADPASRPTFLHMRRNLADI 487
LMR W + RPTF + +L ++
Sbjct: 519 LMRQCWQWSASDRPTFKEIHHSLENM 544
Score = 85.4 bits (202), Expect = 3e-15
Identities = 40/98 (40%), Positives = 61/98 (62%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG ISR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ ++ +
Sbjct: 175 WYHGRISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN-----EDSD 229
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
++ + E F+ + +L+HH+ ADGL T+L+ PK
Sbjct: 230 GKMYVTTESIFNTLAELVHHHSMLADGLITQLLYPAPK 267
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 227 bits (556), Expect = 4e-58
Identities = 116/262 (44%), Positives = 158/262 (60%), Gaps = 6/262 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILK-DREAASKFRAEASVMASL 280
+W+++ D+ ++ +G G++G+V G+ + VAVK LK D +F EA+VM +
Sbjct: 120 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 179
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
KH NLV+LLG V T ++TE G+LLDYLR R V+ + + A ME
Sbjct: 180 KHPNLVQLLG-VCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAME 238
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE++ +HRDLAARN L+ KVADFG AK PIKWTAPE
Sbjct: 239 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAG---AKFPIKWTAPE 295
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
+L YNKFS KSD+W+FG+LLWEI ++G PYP I L++V +E+ YRME PEGCP Y
Sbjct: 296 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 355
Query: 461 ELMRAAWHADPASRPTFLHMRR 482
ELMRA W +P+ RP+F + +
Sbjct: 356 ELMRACWQWNPSDRPSFAEIHQ 377
Score = 84.2 bits (199), Expect = 7e-15
Identities = 43/98 (43%), Positives = 59/98 (60%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG +SR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ TA D
Sbjct: 13 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TASDG-- 68
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+L + E F+ + +L+HH+ ADGL T L PK
Sbjct: 69 -KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 105
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 227 bits (555), Expect = 5e-58
Identities = 116/262 (44%), Positives = 157/262 (59%), Gaps = 6/262 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILK-DREAASKFRAEASVMASL 280
+W+++ D+ ++ +G G++G+V G+ + VAVK LK D +F EA+VM +
Sbjct: 234 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 293
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
KH NLV+LLG V T ++TE G+LLDYLR R V + + A ME
Sbjct: 294 KHPNLVQLLG-VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 352
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE++ +HRDLAARN L+ KVADFG AK PIKWTAPE
Sbjct: 353 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAG---AKFPIKWTAPE 409
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
+L YNKFS KSD+W+FG+LLWEI ++G PYP I L++V +E+ YRME PEGCP Y
Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 469
Query: 461 ELMRAAWHADPASRPTFLHMRR 482
ELMRA W +P+ RP+F + +
Sbjct: 470 ELMRACWQWNPSDRPSFAEIHQ 491
Score = 84.2 bits (199), Expect = 7e-15
Identities = 43/98 (43%), Positives = 59/98 (60%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG +SR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ TA D
Sbjct: 127 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TASDG-- 182
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+L + E F+ + +L+HH+ ADGL T L PK
Sbjct: 183 -KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 219
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 225 bits (549), Expect = 3e-57
Identities = 115/257 (44%), Positives = 153/257 (59%), Gaps = 6/257 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILK-DREAASKFRAEASVMASL 280
+W+++ D+ ++ +G G++G+V G+ + VAVK LK D +F EA+VM +
Sbjct: 183 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 242
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
KH NLV+LLG V T ++TE G+LLDYLR R V + + A ME
Sbjct: 243 KHPNLVQLLG-VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 301
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE++ +HRDLAARN L+ KVADFG K PIKWTAPE
Sbjct: 302 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGT---KFPIKWTAPE 358
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
+L YNKFS KSD+W+FG+LLWEI ++G PYP I L++V +E+ YRME PEGCP Y
Sbjct: 359 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 418
Query: 461 ELMRAAWHADPASRPTF 477
ELMRA W +P+ RP F
Sbjct: 419 ELMRACWQWNPSDRPAF 435
Score = 83.8 bits (198), Expect = 1e-14
Identities = 43/98 (43%), Positives = 59/98 (60%), Gaps = 5/98 (5%)
Query: 58 WHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
W+HG +SR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+ TA D
Sbjct: 76 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TASDG-- 131
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+L + E F+ + +L+HH+ ADGL T L PK
Sbjct: 132 -KLYVSPESRFNTLAELVHHHSTVADGLITTLHYPAPK 168
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 224 bits (548), Expect = 4e-57
Identities = 120/287 (41%), Positives = 159/287 (55%), Gaps = 8/287 (2%)
Query: 195 HFPHAYVAPAA--STDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNG 252
H H + P + Q T+ S W+I D+ ++ +G G++G+V +
Sbjct: 333 HEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKR 392
Query: 253 T-QKVAVKILKDREAASK-FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGS 310
VAVK LK+ A K F EA++M +KH NLV+L+G V T ++TE + G+
Sbjct: 393 YGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIG-VCTREPPFYIITEFMSHGN 451
Query: 311 LLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADF 370
LLD+LRS GR + + + A GM YLE + +HRDLAARN L+ KVADF
Sbjct: 452 LLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADF 511
Query: 371 GXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVP 430
G AK PIKWTAPE L YNKFS KSD+W+FG+LLWEI ++G P
Sbjct: 512 GLARLMRDDTYTAHAG---AKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSP 568
Query: 431 YPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
YP I L +V +++GYRME P GCPP Y+LMR W D RPTF
Sbjct: 569 YPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTF 615
Score = 76.2 bits (179), Expect = 2e-12
Identities = 41/108 (37%), Positives = 63/108 (58%), Gaps = 7/108 (6%)
Query: 50 LVNMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKW 109
L ++ + W+HG ISR AE LLS +G FLVRES + PG ++ +R+ GRV HYR+
Sbjct: 246 LNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI-- 303
Query: 110 ATAPDNQNQRLTIDDEEFFDNMTDLIHHYL--QDADGLCTKLVRCLPK 155
+ PD ++ + E F+ + +L+HH+ + GL T L+ PK
Sbjct: 304 SEDPDG---KVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPK 348
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 223 bits (544), Expect = 1e-56
Identities = 113/287 (39%), Positives = 158/287 (55%), Gaps = 6/287 (2%)
Query: 203 PAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-KVAVKIL 261
PA+ D+ G W++D ++ + +G G++GDV G +AVK L
Sbjct: 283 PASKKDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKAL 342
Query: 262 K-DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGR 320
K D +F AEA++M L H+NLVRLLG V T ++TE G+LL+YLR +
Sbjct: 343 KEDAMPLHEFLAEAAIMKDLHHKNLVRLLG-VCTHEAPFYIITEFMCNGNLLEYLRRTDK 401
Query: 321 HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXX 380
+ + + A GM YLE + +HRDLAARN L+S K+ADFG
Sbjct: 402 SLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDT 461
Query: 381 XXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVV 440
AK PIKWTAPE L +N FS+KSD+W+FG+LLWEI ++G PYP + L+ V
Sbjct: 462 YTAHAG---AKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVY 518
Query: 441 RHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
+E G+RM+ P+GCPP Y LM W+ P+ RP F + NL ++
Sbjct: 519 GLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 565
Score = 72.5 bits (170), Expect = 2e-11
Identities = 39/99 (39%), Positives = 57/99 (57%), Gaps = 5/99 (5%)
Query: 52 NMTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWAT 111
++ ++ W+HG ISR +EA+L G FLVRES G +T+ VR GRV HYR+
Sbjct: 188 SLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRIN--- 244
Query: 112 APDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
DN +++ I E F + +L+HH+ ADGL L+
Sbjct: 245 -VDN-TEKMFITQEVKFRTLGELVHHHSVHADGLICLLM 281
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 220 bits (538), Expect = 6e-56
Identities = 112/274 (40%), Positives = 162/274 (59%), Gaps = 5/274 (1%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDRE-AASKFRAEASVMASLKH 282
W+I + +++ + +G G+FG+V + N + KVAVK LK + F EA++M +L+H
Sbjct: 238 WEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLMKTLQH 297
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
+ LVRL +V T + ++TE+ A GSLLD+L+S+ + I+F+ GM Y+
Sbjct: 298 DRLVRLYAVV-TKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYI 356
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E++ +HRDL A NVL+S K+ADFG AK PIKWTAPEA+
Sbjct: 357 EKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREG---AKFPIKWTAPEAI 413
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
Y F+ KSDMWSFG+LL+EI ++G++PYP + +EV+ V+RGYRM PE CP YE+
Sbjct: 414 NYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVELYEI 473
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
M W P RPTF +++ L D T Q Q
Sbjct: 474 MTTCWKNKPEDRPTFDYIQSVLDDFYTATEGQYQ 507
Score = 44.8 bits (101), Expect = 0.006
Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 12/105 (11%)
Query: 58 WHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVR---FRGR--VEHYRVKWA 110
W + I+R+ AE L + G +L+RES G ++L +R +G+ V+HY+++
Sbjct: 127 WFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYKIR-- 184
Query: 111 TAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
N I + F +++ +I HY + +DGLC KL + K
Sbjct: 185 ---SLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEK 226
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 219 bits (534), Expect = 2e-55
Identities = 117/280 (41%), Positives = 161/280 (57%), Gaps = 11/280 (3%)
Query: 200 YVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVK 259
Y A QT G L+ + W+I++ +++ +G G+FG+V G+ NGT VAVK
Sbjct: 212 YPCLQAEKPQTAGLLRQ---ANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVK 268
Query: 260 ILKDRE-AASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR 318
LK + +F EAS+M L+H L++L V T +VTE GSLL+YLR
Sbjct: 269 TLKPGTMSVEEFLQEASIMKRLRHPKLIQLYA-VCTKEEPIYIVTELMKYGSLLEYLR-- 325
Query: 319 GRHYVTQLNQ-INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
G V ++ Q ++ A GM YLE+Q +HRDLAARN+L+ G KVADFG
Sbjct: 326 GEDGVLKIEQLVDVAAQVASGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVID 385
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
AK PIKWTAPEA YN+F+ KSD+WSFG++L+EI ++GR PYP +
Sbjct: 386 EEIYEAHTG---AKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNP 442
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
EV+ +++ YRM P CP +++M W DPASRPTF
Sbjct: 443 EVLEKIQQNYRMPCPANCPKQFHDIMLDCWREDPASRPTF 482
Score = 60.1 bits (139), Expect = 1e-07
Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 7/95 (7%)
Query: 58 WHHGAISRERAEALLSGSPD--GVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W G I R AE +L+ S + G FL+R+S PGD +L V+ + RV HYRV+
Sbjct: 122 WFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRL----- 176
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
++ L + F + +L+ HY + DGLC KL+
Sbjct: 177 EDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLL 211
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase
Yes; n=422; root|Rep: Proto-oncogene tyrosine-protein
kinase Yes - Homo sapiens (Human)
Length = 543
Score = 216 bits (528), Expect = 1e-54
Identities = 116/283 (40%), Positives = 154/283 (54%), Gaps = 6/283 (2%)
Query: 215 QSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAE 273
Q+Q W+I L + +G+G FG+V +G NGT KVA+K LK + F E
Sbjct: 261 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQE 320
Query: 274 ASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAF 333
A +M L+H+ LV L +V S +VTE ++GSLLD+L+ Y+ ++ A
Sbjct: 321 AQIMKKLRHDKLVPLYAVV--SEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAA 378
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
GM Y+ER +HRDL A N+L+ K+ADFG AK P
Sbjct: 379 QIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQG---AKFP 435
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
IKWTAPEA Y +F+ KSD+WSFGIL E+ + GRVPYP + EV+ VERGYRM P+
Sbjct: 436 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQ 495
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
GCP +ELM W DP RPTF +++ L D T Q Q
Sbjct: 496 GCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 538
Score = 60.9 bits (141), Expect = 8e-08
Identities = 39/104 (37%), Positives = 56/104 (53%), Gaps = 12/104 (11%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVR----FRG-RVEHYRVKWA 110
W+ G + R+ AE LL G+ G+FLVRES G ++L +R RG V+HY+++
Sbjct: 158 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKL 217
Query: 111 TAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLP 154
DN +T + FD + L+ HY + ADGLC KL P
Sbjct: 218 ---DNGGYYITTRAQ--FDTLQKLVKHYTEHADGLCHKLTTVCP 256
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 216 bits (527), Expect = 1e-54
Identities = 119/280 (42%), Positives = 161/280 (57%), Gaps = 7/280 (2%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREA-ASKFRAEA 274
S +D +W+I + + ++E IG+G+FG+V + N T VAVK LK A+ F EA
Sbjct: 332 SHKLID-KWEIPKSSIILKEKIGQGQFGEVFKAVWNKTTIVAVKTLKPSSCDAADFLREA 390
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFD 334
M L H NL++L V T + +VTE+ ++GSLL+YL+S + + I A
Sbjct: 391 QTMKRLHHPNLIQLYA-VCTQTEPFYIVTEYMSKGSLLNYLQSPEGNALNMQCLIMMAAK 449
Query: 335 ACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPI 394
GM YLE +R +HRDLAARNVL+ + K+ADFG A+ PI
Sbjct: 450 IAPGMAYLESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHNREYVAHAG---ARFPI 506
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG 454
KWT+PEA Y++F+ KSD+WSFGILL EI ++GR PYP + AEV+R V+ GYRM P G
Sbjct: 507 KWTSPEAANYSRFTIKSDVWSFGILLTEIVTYGRSPYPGMHNAEVLRQVDAGYRMSKPPG 566
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLADI-RDHTPA 493
CPP Y+LM W AD RP+F + L D PA
Sbjct: 567 CPPELYDLMLECWAADENKRPSFATIHFRLEQFCEDEQPA 606
Score = 57.6 bits (133), Expect = 7e-07
Identities = 33/95 (34%), Positives = 52/95 (54%), Gaps = 3/95 (3%)
Query: 58 WHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWA-TAPD 114
W+ G + R AE L G+ G FLVR S + +++L VR V+HYR++ + D
Sbjct: 222 WYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIRSRYSRTD 281
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+R I + F N+ L++HYL++ GLC +L
Sbjct: 282 PTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRL 316
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 212 bits (517), Expect = 2e-53
Identities = 111/274 (40%), Positives = 158/274 (57%), Gaps = 6/274 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDRE-AASKFRAEASVMASLKH 282
W+I L++ + +G G+FG+V + N KVAVK +K + F AEA+VM +L+H
Sbjct: 255 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQH 314
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
+ LV+L +V + ++TE A+GSLLD+L+S I+F+ GM ++
Sbjct: 315 DKLVKLHAVV--TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 372
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E++ +HRDL A N+L+SA K+ADFG AK PIKWTAPEA+
Sbjct: 373 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREG---AKFPIKWTAPEAI 429
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
+ F+ KSD+WSFGILL EI ++GR+PYP + EV+R +ERGYRM PE CP Y +
Sbjct: 430 NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNI 489
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
M W P RPTF +++ L D T +Q Q
Sbjct: 490 MMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
Score = 46.0 bits (104), Expect = 0.002
Identities = 32/99 (32%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 58 WHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W ISR+ AE L G+ G F++R+S G ++L VR + VK
Sbjct: 144 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 203
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL-VRCL 153
N I F + +L+ HY + DGLC KL V C+
Sbjct: 204 DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 211 bits (516), Expect = 3e-53
Identities = 105/265 (39%), Positives = 153/265 (57%), Gaps = 2/265 (0%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREA-ASKFRAEASVMASLK 281
+W+ID +++ + +G G+FG+V G+ N T VAVK LK + F EA +M +L+
Sbjct: 226 QWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H L++L V T ++TE GSL +YL++ + Q++ A GM Y
Sbjct: 286 HPKLIQLYA-VCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE + +HRDLAARNVL+ KVADFG + KLP+KWTAPEA
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA 404
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
++ NKFS KSD+WSFGILL+EI ++G++PY + A+V++ + + YR+ P CP Y
Sbjct: 405 IRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYN 464
Query: 462 LMRAAWHADPASRPTFLHMRRNLAD 486
+M W+A+P RPTF +R L D
Sbjct: 465 IMLECWNAEPKERPTFETLRWKLED 489
Score = 57.2 bits (132), Expect = 1e-06
Identities = 38/100 (38%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 57 PWHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW GAI R AE L S + G FL+RES + G+ +L V V+HYR+K D
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIK---RLD 171
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVR-CL 153
LT F + + + HY + +DGLC KL + CL
Sbjct: 172 EGGFFLT--RRRIFSTLNEFVSHYTKTSDGLCVKLGKPCL 209
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 211 bits (516), Expect = 3e-53
Identities = 105/267 (39%), Positives = 152/267 (56%), Gaps = 6/267 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAAS-KFRAEASVMASLKH 282
W+ID +DL + +G G+FG V G G VA+K++K+ + +F EA VM +L H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
E LV+L G V T ++TE+ A G LL+YLR + TQ + D C MEYL
Sbjct: 455 EKLVQLYG-VCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQ-QLLEMCKDVCEAMEYL 512
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E ++ +HRDLAARN L++ +G KV+DFG +K P++W+ PE L
Sbjct: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVG---SKFPVRWSPPEVL 569
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
Y+KFS+KSD+W+FG+L+WEIYS G++PY R +E H+ +G R+ P Y +
Sbjct: 570 MYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 629
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRD 489
M + WH RPTF + N+ D+ D
Sbjct: 630 MYSCWHEKADERPTFKILLSNILDVMD 656
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 208 bits (509), Expect = 2e-52
Identities = 114/274 (41%), Positives = 150/274 (54%), Gaps = 6/274 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREA-ASKFRAEASVMASLKH 282
W+I R +++ +G G+FG+V G NGT +VAVK LK+ + F EA++M L+H
Sbjct: 295 WEIPRRSIKLERKLGNGQFGEVWEGTWNGTVRVAVKTLKEGAMDPTAFLQEANIMKKLRH 354
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
LV LL V + +VTE G LLDYL + + I+ GM YL
Sbjct: 355 PKLVALLA-VCSEGEPIYIVTELMTNGCLLDYLHEGEGKQLREPELIDITAQVADGMAYL 413
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E QR VHRDLAARN+L+ KVADFG AK+PIKWTAPEA+
Sbjct: 414 ESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIEDEYIAKEG----AKMPIKWTAPEAI 469
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
+ KF+ KSD+WSFGIL++E+ + GRVPYP + EV+ V RGYRM P CP Y++
Sbjct: 470 NFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGYRMPKPPECPDQLYDI 529
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
+ W A P RPTF + L D + Q Q
Sbjct: 530 TKQCWDAVPEKRPTFEFLHSFLDDFYHASEIQYQ 563
Score = 49.2 bits (112), Expect = 3e-04
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W ++R+ AE L +G+ G FL+R S PG ++L V + VK
Sbjct: 183 WFFEKMTRKEAEKQLQLAGNSRGTFLIRGSETSPGAYSLSVLDHDDARGFNVKHYRIRTL 242
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
N I F + DL++HY ADGL +L+ P+
Sbjct: 243 DNDGYYISTRITFHTLHDLVNHYTSQADGLVCRLLNPCPR 282
>UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase BLK - Homo
sapiens (Human)
Length = 505
Score = 207 bits (505), Expect = 6e-52
Identities = 108/276 (39%), Positives = 159/276 (57%), Gaps = 8/276 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLKH 282
W+I + L + +G G+FG+V +G KVA+K LK+ + + F EA+VM +L+H
Sbjct: 234 WEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQH 293
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
E LVRL +V + +VTE+ A+G LLD+L++ ++ I+ + GM Y+
Sbjct: 294 ERLVRLYAVV--TKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYI 351
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
ER +HRDL A N+L+S K+ADFG AK PIKWTAPEA+
Sbjct: 352 ERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEG----AKFPIKWTAPEAI 407
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE- 461
+ F+ K+D+WSFG+LL E+ ++GRVPYP + EV+R++ERGYRM P+ CPP Y
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
Query: 462 LMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
++ W + P RPTF ++ L D T Q +L
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYEL 503
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 206 bits (504), Expect = 8e-52
Identities = 141/438 (32%), Positives = 202/438 (46%), Gaps = 29/438 (6%)
Query: 60 HGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQN 117
H AI R A L G DG FL+R ++ PG + L + ++ HY V + +
Sbjct: 294 HKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTPYHYEVVCES-----D 348
Query: 118 QRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPKXXXXXXXXXX-------XXXXX 170
IDD FD + ++ HY ADGL T L+ +P
Sbjct: 349 CWYFIDDGPLFDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVPFSSPPQPGALLFAQG 408
Query: 171 XXXXXXXXXXXXXXXSVPSALAAGHFPHAYVAPAASTDQTDGTLQSQSFVDARWKIDERD 230
+VP FP A +AP Q L + + I E D
Sbjct: 409 LKNLPKHLQAHLTASTVPRMRDQPPFPVAALAPPPPPIQI---LAREKGPQLSY-ISEHD 464
Query: 231 LEIRENIGKGEFGDVMLGILNGTQ----KVAVKILK---DREAASKFRAEASVMASLKHE 283
L + +G+GEFG V+ G+ G +VAVK L+ +F EA +M +L H
Sbjct: 465 LHLGAELGQGEFGSVLKGLYKGADGKKIEVAVKTLRLDSQGHGEKEFAREAGIMVTLNHP 524
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
+V+L+G+ T+ +V E + G+L+DYL R + L +A + GM YLE
Sbjct: 525 CIVKLIGI--TNGKPMMMVQELISMGALVDYLYERKQPIPDVLTLKLWAAEIASGMMYLE 582
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
+R VHRDLAARN+L+ + K++DFG + P+KW APE++
Sbjct: 583 TKRFVHRDLAARNILVQSMKQVKISDFGLSRAVGANSDYYKASQG-GRWPVKWYAPESIN 641
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEGCPPGPYEL 462
+ FS+ SD+WS+GI LWE++SFG PY + AEV+ VE YR+E P CP YEL
Sbjct: 642 FGTFSHASDVWSYGITLWEMFSFGDAPYGDMTGAEVLDRVENLNYRLECPRDCPSSIYEL 701
Query: 463 MRAAWHADPASRPTFLHM 480
M W +P RPTF +
Sbjct: 702 MLRCWSLEPNERPTFAQL 719
Score = 63.3 bits (147), Expect = 1e-08
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 9/96 (9%)
Query: 58 WHHGAISRERAEALLSGSP----DGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAP 113
W+HG I+RE A L+S P +G+FLVREST PG + L + +G V+ +++
Sbjct: 10 WYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIM----- 64
Query: 114 DNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ ++D+ F + +LIHHY DGL +L
Sbjct: 65 GHGEGWFSVDNGPLFQGLDELIHHYQLKPDGLPVQL 100
>UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular
organisms|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 206 bits (503), Expect = 1e-51
Identities = 102/259 (39%), Positives = 147/259 (56%), Gaps = 6/259 (2%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAAS--KFRAEASVMA 278
D +W + D+++ +GKG FGDV L G KVAVK + + KF EA ++
Sbjct: 624 DDKWALKHEDIKMGRKLGKGAFGDVWEAALKGQGKVAVKTCRSTDVPDREKFLQEAEILK 683
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
H N+V+L+G+ + + +V E GSLLDYLR + +T+ ++ + DAC G
Sbjct: 684 QYDHPNIVKLIGVSWDTEP-VLIVMELMPGGSLLDYLRKKAAQ-MTKGKLLHMSIDACGG 741
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
MEYLE + +HRDLAARN L+ K++DFG Q +PIKWTA
Sbjct: 742 MEYLESKNCIHRDLAARNCLVGENDIVKISDFGMSREEEGGMYTVQSGTRQ--IPIKWTA 799
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEAL Y ++++ SD+WSFG+LL+E++S G PYP + AE V+ GYRM P+GCP
Sbjct: 800 PEALNYGRYTSASDVWSFGVLLYEVFSGGSTPYPGMSNAETRTQVDSGYRMPPPQGCPAE 859
Query: 459 PYELMRAAWHADPASRPTF 477
+++M+ W D RP F
Sbjct: 860 IHQIMQLCWAYDAEDRPKF 878
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 203 bits (495), Expect = 1e-50
Identities = 107/295 (36%), Positives = 159/295 (53%), Gaps = 9/295 (3%)
Query: 198 HAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-V 256
H + + T ++ L + D +W ++ D+ + E +GKG FG+V G L + V
Sbjct: 519 HHFSSKQVITKKSGVVLLNPVVKDKKWILNHEDVVLGELLGKGNFGEVFKGTLQRDKTPV 578
Query: 257 AVKILKD---REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLD 313
AVK K+ E +F +EA ++ H N+V+L+G V T +V E G L
Sbjct: 579 AVKTCKEDLPSELKIRFLSEARILKQYDHPNIVKLIG-VCTQRQPIYIVMELVPGGDFLS 637
Query: 314 YLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX 373
YLR + T+ + FA DA GM YLE + +HRDLAARN L+ K++DFG
Sbjct: 638 YLRKKKDELKTK-QLLRFAVDAAAGMAYLESKNCIHRDLAARNCLVGDNNALKISDFGMS 696
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
++PIKWTAPEAL Y ++S++SD+WS+GILLWE +S G PYP
Sbjct: 697 RQEDDGIYSSSGLK---QIPIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGMCPYPG 753
Query: 434 IPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
+ + VE+GYRM P+ CP Y++M+ W +P RP F ++R+LA ++
Sbjct: 754 MTNQQAREQVEKGYRMACPQRCPDDVYKVMQRCWQYNPEDRPKFSELQRDLAAVK 808
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 201 bits (491), Expect = 3e-50
Identities = 107/268 (39%), Positives = 148/268 (55%), Gaps = 12/268 (4%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLK 281
+W+I +L + E +G G+FG V G G+ AVK++K+ + F EA VM L+
Sbjct: 518 KWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC---- 337
H NLV+L G V + +VTE+ GSLL+YLR RH T + + D C
Sbjct: 578 HPNLVQLYG-VCSKHRPIYIVTEYMKHGSLLNYLR---RHEKTLIGNMGLLLDMCIQVSK 633
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YLER +HRDLAARN L+ +E KVADFG K PIKW
Sbjct: 634 GMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGT---KFPIKWA 690
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
PE L Y +FS+KSD+W++G+L+WEI++ G++PY R+ EVV V+RG +E P+ C
Sbjct: 691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAK 750
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLA 485
Y++M+ W P RP F + LA
Sbjct: 751 EIYDVMKLCWSHGPEERPAFRVLMDQLA 778
Score = 48.4 bits (110), Expect = 5e-04
Identities = 30/104 (28%), Positives = 58/104 (55%), Gaps = 10/104 (9%)
Query: 50 LVNMTQWPWHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHTLCVRFR---GRVEHY 105
L+ + ++ W+ G +SR+RAE+LL G +G F+VR+S+ G +TL + + V+HY
Sbjct: 402 LLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHY 460
Query: 106 RVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+K N + ++ + + DLI+++ ++ GL +L
Sbjct: 461 HIK-----QNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRL 499
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 200 bits (489), Expect = 5e-50
Identities = 107/294 (36%), Positives = 154/294 (52%), Gaps = 8/294 (2%)
Query: 198 HAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVA 257
H Y T ++ L + D +W + D+ + E +GKG FG+V G L VA
Sbjct: 530 HHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVA 589
Query: 258 VKILKD---REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDY 314
VK K+ +E KF EA ++ H N+V+L+G V T ++ E + G L +
Sbjct: 590 VKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIG-VCTQRQPVYIIMELVSGGDFLTF 648
Query: 315 LRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
LR R + + + F+ DA GM YLE + +HRDLAARN L+ K++DFG
Sbjct: 649 LR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSR 707
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
++PIKWTAPEAL Y ++S++SD+WSFGILLWE +S G PYP +
Sbjct: 708 QEDGGVYSSSGLK---QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 764
Query: 435 PLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
+ VERGYRM AP+ CP ++M W P +RP F +++ L I+
Sbjct: 765 TNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818
Score = 45.2 bits (102), Expect = 0.004
Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 10/87 (11%)
Query: 53 MTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATA 112
+ + W+HGAI R A+ LL D FLVRES PG++ L V G+ H+ +++
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQGD--FLVRESHGKPGEYVLSVYSDGQRRHFIIQYV-- 510
Query: 113 PDNQNQRLTIDDEEFFDNMTDLI-HHY 138
DN + + F N+ LI HHY
Sbjct: 511 -DNMYR----FEGTGFSNIPQLIDHHY 532
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 198 bits (483), Expect = 3e-49
Identities = 142/434 (32%), Positives = 202/434 (46%), Gaps = 38/434 (8%)
Query: 57 PWHHGAISRERAEALLSGSP--DGVF---LVRESTNFPGDHTLCVRFRGRVEHYRVKWAT 111
PW HG I RE +E L + +G R+ + LC+ +V HYR+
Sbjct: 162 PWFHGKIDREDSELRLLNTSRVNGQISNQTKRKQWQKRVPNALCLLHNNQVMHYRID--- 218
Query: 112 APDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPKXXXXXXXXXXXXXXXX 171
++ +L+I D + FD + L+ HY DGL L P+
Sbjct: 219 --KDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSEGSAENPYKIT 276
Query: 172 XXXXXXXXXXXXXXSVPSALAAGHFPHAYVAPAASTDQTDGTLQSQSFVDARWKIDERDL 231
+ SA+ Y +P A D+ T K++ DL
Sbjct: 277 SNGKDNYSKQGNF--LDSAMPMD--TQVYESPYADPDELRST-----------KVNRSDL 321
Query: 232 EIREN-IGKGEFGDVMLGI--LNGTQKV-AVKILK--DREAASK--FRAEASVMASLKHE 283
+ + +G G FG V+ G+ + TQKV AVKILK D AA K EA+VM L +
Sbjct: 322 TLEDGELGSGNFGTVLRGVYQMKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNP 381
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
+VR++G+ + LV E G L +L+ + +H +T N GM+YLE
Sbjct: 382 YIVRMIGIC--EAENLMLVMELAELGPLHKFLQ-KNKH-ITVKNLTELVHQVSMGMKYLE 437
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
VHRDLAARNVL+ + AK++DFG K P+KW APE +
Sbjct: 438 EHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKG-HGKWPLKWYAPECMN 496
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
Y KFS+KSD+WSFG+L+WE +S+G+ PY + EV++ +E G RM AP CPP Y+LM
Sbjct: 497 YLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLM 556
Query: 464 RAAWHADPASRPTF 477
+ W P RP F
Sbjct: 557 KKCWTYKPDERPGF 570
Score = 44.8 bits (101), Expect = 0.006
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 57 PWHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
P+ G I+RE +E L GS DG++L+R+S +F G + L + + + HY T
Sbjct: 9 PYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHY-----TIER 63
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGL 145
N I + D+I+++ Q++DGL
Sbjct: 64 ELNDTYAIAGGKSHRTPIDVINYHSQESDGL 94
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 195 bits (476), Expect = 2e-48
Identities = 103/268 (38%), Positives = 143/268 (53%), Gaps = 5/268 (1%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREA-ASKFRAEASVMAS 279
D W+ID+ L + + +G G+FG V+ G G VA+K++++ F EA VM
Sbjct: 423 DEAWEIDKVSLSLGKELGSGQFGRVVSGKWKGKIDVAIKMMREGAMNEDDFIEEAKVMKQ 482
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGM 339
+HENLV+L G V T +G +V E G LL +LR R ++ A C M
Sbjct: 483 FQHENLVKLYG-VCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKTEIILDMATQICSAM 541
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
+YLE +HRDLAARN L+ KVADFG K PIKW AP
Sbjct: 542 KYLEESGFIHRDLAARNCLVGERNVVKVADFGLARFVVDDEYTASEGT---KFPIKWAAP 598
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGP 459
E + + KFS+KSD+WSFGILLWE+++ G+ PYP ++V+ V GYR++ P+ CPP
Sbjct: 599 EVITHAKFSSKSDVWSFGILLWELWTGGKTPYPTFTNSQVLDEVLMGYRLDRPKQCPPEV 658
Query: 460 YELMRAAWHADPASRPTFLHMRRNLADI 487
Y LM W + RP F + +L +
Sbjct: 659 YALMGKCWLTNSDDRPQFKTLSSSLGQM 686
Score = 45.6 bits (103), Expect = 0.003
Identities = 28/93 (30%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 58 WHHGAISRERAEALLSGSP-DGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQ 116
W +SR RAE +L G +G F+VR S+ +TL + G+V HY +K ++
Sbjct: 318 WFFPQLSRTRAENILKGEGREGGFVVRNSSR-ENMYTLSICHEGQVRHYHIKL-----DE 371
Query: 117 NQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ + I ++ F ++ +LI ++ + GL T+L
Sbjct: 372 SNKYFISEKHRFPSIKELIEYHKLNGGGLVTRL 404
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 194 bits (474), Expect = 4e-48
Identities = 103/265 (38%), Positives = 145/265 (54%), Gaps = 6/265 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLKH 282
W+ID R L +G G+FG V G G VA+K++K+ + F EA VM L H
Sbjct: 330 WEIDPRQLTFIRELGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVMMKLCH 389
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
NLV+L G V T +VTE+ A G LL+YL+ G T + + D GM+YL
Sbjct: 390 GNLVQLYG-VCTKQRPIYIVTEYLANGCLLNYLQE-GLLNPTSIALLEMCKDVSEGMKYL 447
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E + +HRDLAARN L+ + GT KV DFG +K P++W+ PE L
Sbjct: 448 EANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSSVG---SKFPVRWSPPEVL 504
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
Y KFS+KSD+W+FG+L+WEIY+ GR+PY R E+V + G+R+ P+ + +
Sbjct: 505 LYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAI 564
Query: 463 MRAAWHADPASRPTFLHMRRNLADI 487
M + WH P RPTF + + D+
Sbjct: 565 MNSCWHERPDERPTFQELVGVIKDL 589
Score = 38.7 bits (86), Expect = 0.36
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 12/102 (11%)
Query: 50 LVNMTQWPWHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHTLCV------RFRGRV 102
L + ++ W+ I+R +AE LL + + DG FLVR+S F G +T+ V G
Sbjct: 232 LNGLEKYDWYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSC 291
Query: 103 EHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADG 144
HY + D Q + ++ F N+ +LI+++ +A G
Sbjct: 292 RHYNI--LLTADGQ---FYLAEKHNFTNIPELINYHQHNAAG 328
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 194 bits (474), Expect = 4e-48
Identities = 102/266 (38%), Positives = 146/266 (54%), Gaps = 6/266 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLK 281
+W+I+ +L +G G FG V LG KVA+K +++ + F EA VM L
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H LV+L G V T +VTE +G LL++LR R H+ + ++ D C GMEY
Sbjct: 422 HPKLVQLYG-VCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV-LLSMCQDVCEGMEY 479
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LER +HRDLAARN L+S G KV+DFG AK P+KW PE
Sbjct: 480 LERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG---AKFPVKWCPPEV 536
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
Y++FS+KSD+WSFG+L+WE+++ GR+P+ + EVV V RG+R+ P+ YE
Sbjct: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
Query: 462 LMRAAWHADPASRPTFLHMRRNLADI 487
+M W P RP+F + R + ++
Sbjct: 597 VMLRCWQEKPEGRPSFEDLLRTIDEL 622
Score = 45.2 bits (102), Expect = 0.004
Identities = 32/110 (29%), Positives = 59/110 (53%), Gaps = 11/110 (10%)
Query: 47 GNRLVNMTQWPWHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHT--LCVRFRGR-- 101
G + N+ Q+ W+ ++R +AE LL S +G F+VR+S+ PG +T L +F G
Sbjct: 236 GKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGS 294
Query: 102 --VEHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
HY +K T ++ + ++ F ++ ++I ++ +A GL T+L
Sbjct: 295 SGFRHYHIKETT---TSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRL 341
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 194 bits (472), Expect = 6e-48
Identities = 102/270 (37%), Positives = 145/270 (53%), Gaps = 8/270 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-VAVKILKDR---EAASKFRAEASVMA 278
+W ++ DL + E IG+G FG+V G L VAVK ++ + +KF EA ++
Sbjct: 483 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
H N+VRL+G V T +V E G L +LR+ G + + DA G
Sbjct: 543 QYSHPNIVRLIG-VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVK-TLLQMVGDAAAG 600
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
MEYLE + +HRDLAARN L++ + K++DFG Q +P+KWTA
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGSRQ--VPVKWTA 658
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEAL Y ++S++SD+WSFGILLWE +S G PYP + + VE+G R+ PE CP
Sbjct: 659 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDA 718
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLADIR 488
+ LM W +P RP+F + + L IR
Sbjct: 719 VFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 193 bits (470), Expect = 1e-47
Identities = 103/260 (39%), Positives = 145/260 (55%), Gaps = 6/260 (2%)
Query: 223 RWKIDERDL-EIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAA-SKFRAEASVMASL 280
+W+ + L ++ +G+G+FG+V G+ NG VAVK LK+R + + F AEA+VM L
Sbjct: 117 KWETPRKSLGQMNRRLGEGKFGEVWQGVWNGNTPVAVKTLKERTMSPAAFLAEANVMKKL 176
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
+HE +V+L V + +VTE + G L YL+S I+ GM+
Sbjct: 177 RHEGIVQLYA-VCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGAHIASGMD 235
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YL + VVHRDLAARNVL+ K+ADFG AKLP+KWTAPE
Sbjct: 236 YLGSKNVVHRDLAARNVLVGKGNVVKIADFGRAQLMEKDVYVGEEG---AKLPLKWTAPE 292
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
A+ + +F+ KSD+WSFGIL+ E+ +FG PY ++ EV + V GYRM + C Y
Sbjct: 293 AVLHGRFTIKSDVWSFGILMTEMVTFGGYPYKKMRTREVTKKVANGYRMPKMDHCTDSLY 352
Query: 461 ELMRAAWHADPASRPTFLHM 480
+M WH DP RPTF ++
Sbjct: 353 MIMLKCWHKDPQQRPTFKYL 372
Score = 48.4 bits (110), Expect = 5e-04
Identities = 36/105 (34%), Positives = 47/105 (44%), Gaps = 13/105 (12%)
Query: 58 WHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRG-----RVEHYRVKWA 110
W G SR+ AE L G G F+VR+ PG L VR V+HYR+ W
Sbjct: 7 WDFGMCSRQDAEKKLMAIGINKGQFIVRDRD--PGTFELSVRDNNPQKGDHVKHYRI-WK 63
Query: 111 TAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
N I F +++L+ HY ++DGLC KL PK
Sbjct: 64 MDGGNS---FFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPK 105
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 510
Score = 192 bits (468), Expect = 2e-47
Identities = 101/264 (38%), Positives = 140/264 (53%), Gaps = 6/264 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK-DREAASKFRAEASVMASLKH 282
W++ + + + E +GKG F DV G G VA+KILK D +F E ++ L+H
Sbjct: 236 WELPKEEFTLEEELGKGFFADVYRGKWKGMVNVAIKILKNDSINHREFMLETQILKKLRH 295
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
++L+ L V TSS ++TE +G LL L+ + + A GM YL
Sbjct: 296 KHLIALFA-VCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQMLTEMASQVADGMAYL 354
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E Q +HRDLAARNVL+ A KVAD G A++P KW+APEA+
Sbjct: 355 EEQNSIHRDLAARNVLVGANYICKVADLGLARIVKESVYSSE----DAQIPYKWSAPEAI 410
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
+ +FSNKSD+WSFG+LL+E++++G VPYP EV + GYRM AP CP Y++
Sbjct: 411 SHGRFSNKSDVWSFGVLLYEMFTYGGVPYPAFSNIEVYNMITSGYRMPAPPNCPSHIYDI 470
Query: 463 MRAAWHADPASRPTFLHMRRNLAD 486
M W RP F + R L D
Sbjct: 471 MLMCWRYSAEERPDFSELLRLLED 494
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 192 bits (468), Expect = 2e-47
Identities = 100/258 (38%), Positives = 149/258 (57%), Gaps = 7/258 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDRE-AASKFRAEASVMASLK 281
+++I ++++ +G+G FG+V G + VAVK L++ + + F EA++M +
Sbjct: 276 KYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFR 335
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H LV L V + +V E+ ++GSLLD+LR Y+ + I A GMEY
Sbjct: 336 HNRLVALYA-VCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEY 394
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE ++++HRDLAARNVLI AK+ DFG ++ P+KWTAPEA
Sbjct: 395 LESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQG---SRFPVKWTAPEA 451
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG--CPPGP 459
+ Y KFS KSD+WS+GILL E++++G+VPYP + EV+ ++ERG+RM P P
Sbjct: 452 IIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNI 511
Query: 460 YELMRAAWHADPASRPTF 477
Y+L+ W A P RPTF
Sbjct: 512 YQLLLQCWDAVPEKRPTF 529
Score = 43.2 bits (97), Expect = 0.017
Identities = 35/112 (31%), Positives = 51/112 (45%), Gaps = 4/112 (3%)
Query: 46 AGNRLVNMTQWPWHHGAISRERAEALLSG--SPDGVFLVRESTNFPGDHTLCVRFRGRVE 103
A R VN W + + + R+ A+ LL +P G FLVR S + P ++L V+
Sbjct: 152 AEERSVNSEDWFFEN--VLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGR 209
Query: 104 HYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
Y VK N I + F ++ L+ Y ++A GLC L R PK
Sbjct: 210 GYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPK 261
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 192 bits (467), Expect = 2e-47
Identities = 112/271 (41%), Positives = 151/271 (55%), Gaps = 16/271 (5%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL----NGTQKVAVKILK----DREAA 267
+Q+ + +ID + I E IG GEFGDV G++ T KVAVK LK D++
Sbjct: 402 NQAVKEFATEIDATQIRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDR- 460
Query: 268 SKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQL 326
S F +EAS+M H N+++LLG+V T + +VTE GSL YLR GR VTQL
Sbjct: 461 SDFLSEASIMGQFDHPNVIKLLGVV-TKTRPAMIVTEFMENGSLDKYLRENDGRFTVTQL 519
Query: 327 NQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXX 386
+ GM +L VHRDLAARN+L++ KVADFG
Sbjct: 520 --LGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAYETRG 577
Query: 387 XXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG 446
K+PI+WTAPEA+ Y KF++ SD+WS G+++WEI S+G PY P +V++ VE+G
Sbjct: 578 ---GKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIKAVEKG 634
Query: 447 YRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
YR+ P CP ++LM W D RPTF
Sbjct: 635 YRLPPPMECPEAIHQLMLDCWQRDRNHRPTF 665
>UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG18247-PA - Tribolium castaneum
Length = 725
Score = 191 bits (466), Expect = 3e-47
Identities = 134/429 (31%), Positives = 207/429 (48%), Gaps = 24/429 (5%)
Query: 58 WHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W+HG + R AE + + DG FLVR S + L + +Y ++
Sbjct: 286 WYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESLFYNYIIR------K 338
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPKXXXXXXXXXXXXXXXXXXXX 175
Q+ L ID+ + +++ +I +Y DGL T L +P
Sbjct: 339 QDDYLFIDNGPYLESLEHIIEYYSFIPDGLPTVLQTPVPPKPKPPVPECTTIPRQRKKNL 398
Query: 176 XXXXXXXXXXSVPSALAAGHFPHAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRE 235
S+ + + FP + +T+ ++ + + + + ER L++
Sbjct: 399 RPQPEII---SIAESQSLKCFPSQFQNIHFTTNFSNNNNYTTNDNEDDYIPLER-LKMGR 454
Query: 236 NIGKGEFGDVMLGIL---NGTQ-KVAVKILKDR--EAASKFRAEASVMASLKHENLVRLL 289
IG+GEFG V G NG + KVA+K ++ E ++ EA VM L H +V+L+
Sbjct: 455 VIGEGEFGSVYEGTYTKRNGEEIKVAIKTVRHEQIETSNAILKEAHVMMRLNHHCVVKLI 514
Query: 290 GLVFTSSGGTCL-VTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVV 348
GL S G L V E A GS+L+Y+ +A CGM YLE QR +
Sbjct: 515 GL---SKGRPLLMVQELVALGSMLNYIILNKESINPNSEFKIWAAQIACGMNYLEEQRFI 571
Query: 349 HRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFS 408
HRDLAARN+L++++ AK++DFG K P+KW APE+ Y +FS
Sbjct: 572 HRDLAARNILLASQHQAKISDFGLSRALAADHEYYRALQG-GKWPLKWYAPESYNYGQFS 630
Query: 409 NKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWH 468
+KSD+WSFG+ +WE+YSFG VPY + ++ ++ +E G R++ P+ CP YE+MR W
Sbjct: 631 HKSDVWSFGVAIWEMYSFGDVPYGELKGSDAIKIIEDGERLKQPDACPDHIYEIMRRCWE 690
Query: 469 ADPASRPTF 477
D +RPTF
Sbjct: 691 YDAENRPTF 699
Score = 58.8 bits (136), Expect = 3e-07
Identities = 31/84 (36%), Positives = 45/84 (53%), Gaps = 6/84 (7%)
Query: 58 WHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W+HG +SRE E LL G PDG FLVRES + GD L V V H++++ +
Sbjct: 9 WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIR----RHS 64
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYL 139
++ +ID+ + LI HY+
Sbjct: 65 EDAFFSIDENTKIHGLESLIEHYV 88
>UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase
LCK; n=11; Coelomata|Rep: Proto-oncogene
tyrosine-protein kinase LCK - Homo sapiens (Human)
Length = 516
Score = 191 bits (466), Expect = 3e-47
Identities = 103/247 (41%), Positives = 142/247 (57%), Gaps = 6/247 (2%)
Query: 251 NGTQKVAVKILKDREAA-SKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQG 309
NG KVAVK LK + F AEA++M L+H+ LVRL +V + ++TE+ G
Sbjct: 272 NGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVV--TQEPIYIITEYMENG 329
Query: 310 SLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVAD 369
SL+D+L++ +T ++ A GM ++E + +HRDL A N+L+S + K+AD
Sbjct: 330 SLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIAD 389
Query: 370 FGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRV 429
FG AK PIKWTAPEA+ Y F+ KSD+WSFGILL EI + GR+
Sbjct: 390 FGLARLIEDNEYTAREG---AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRI 446
Query: 430 PYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
PYP + EV++++ERGYRM P+ CP Y+LMR W P RPTF ++R L D
Sbjct: 447 PYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFT 506
Query: 490 HTPAQLQ 496
T Q Q
Sbjct: 507 ATEGQYQ 513
Score = 38.3 bits (85), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 57 PWHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW +SR+ AE L G+ G FL+RES + G +L VR + + VK +
Sbjct: 184 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRN 243
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCL 153
N I F + +L+ HY + +G V+ L
Sbjct: 244 LDNGGFYISPRITFPGLHELVRHYTRYYNGHTKVAVKSL 282
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 190 bits (462), Expect = 1e-46
Identities = 98/268 (36%), Positives = 140/268 (52%), Gaps = 6/268 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLK 281
+W ID +L + IG G+FG V LG KVA+K +++ + + F EA VM L
Sbjct: 355 KWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLS 414
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H LV+L G V CLV E G L DYLR++ + + + D C GM Y
Sbjct: 415 HPKLVQLYG-VCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAE-TLLGMCLDVCEGMAY 472
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE V+HRDLAARN L+ KV+DFG K P+KW +PE
Sbjct: 473 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGT---KFPVKWASPEV 529
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
++++S+KSD+WSFG+L+WE++S G++PY +EVV + G+R+ P Y+
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 462 LMRAAWHADPASRPTFLHMRRNLADIRD 489
+M W P RP F + R LA+I +
Sbjct: 590 IMNHCWKERPEDRPAFSRLLRQLAEIAE 617
Score = 44.4 bits (100), Expect = 0.007
Identities = 32/106 (30%), Positives = 58/106 (54%), Gaps = 12/106 (11%)
Query: 52 NMTQWPWHHGAISRERAE-ALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRV-------E 103
N+ + W++ +ISR++AE LL +G F+VR+S G +T+ V + V +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIK 291
Query: 104 HYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
HY +K DN +R + ++ FD++ LI+++ + GL T+L
Sbjct: 292 HYHIK--ETNDNP-KRYYVAEKYVFDSIPLLINYHQHNGGGLVTRL 334
>UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1;
Schistosoma mansoni|Rep: Fes-like tyrosine kinase protein
- Schistosoma mansoni (Blood fluke)
Length = 1259
Score = 189 bits (461), Expect = 1e-46
Identities = 100/258 (38%), Positives = 150/258 (58%), Gaps = 11/258 (4%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAAS----KFRAEASVMAS 279
W++D RD+++ + IG+G FGDV G+ NG + VAVK + AS KF + +
Sbjct: 954 WELDNRDVQLLQKIGQGNFGDVYRGVYNGCE-VAVKTCRVDMTASDLRRKFLQGETTALN 1012
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGM 339
H N+V+L+G+ S +V E+ GSLL++LR + ++ + + + + DA GM
Sbjct: 1013 FNHPNIVKLVGIA-VQSYPIMIVMEYVPGGSLLNHLR-KSKNALPVMKLLQMSLDAANGM 1070
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
YLE + +HRDLAARN LIS +G K+ADFG + ++PIKWTAP
Sbjct: 1071 MYLEARNCIHRDLAARNCLISDDGQLKIADFGMSREEHIYELSDK----RGQIPIKWTAP 1126
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGP 459
EAL+ +++ K D+WS+G+LLWEI++FG VPY + +E GYR+ AP+ P
Sbjct: 1127 EALRTGRYTIKCDVWSYGVLLWEIFTFGDVPYRNWSNQQTRDMIESGYRLPAPDLMPVWL 1186
Query: 460 YELMRAAWHADPASRPTF 477
LM WH +P +RP+F
Sbjct: 1187 RTLMNHCWHDEPMNRPSF 1204
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 189 bits (460), Expect = 2e-46
Identities = 97/275 (35%), Positives = 150/275 (54%), Gaps = 6/275 (2%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAAS-KFRAEA 274
S S + W++ ++ + + +G G+FG V LG G VAVK++K+ + +F EA
Sbjct: 402 SVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEA 461
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFD 334
M L H LV+ G V + +VTE+ + G LL+YLRS G+ + + +D
Sbjct: 462 QTMMKLSHPKLVKFYG-VCSKEYPIYIVTEYISNGCLLNYLRSHGKG-LEPSQLLEMCYD 519
Query: 335 ACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPI 394
C GM +LE + +HRDLAARN L+ + KV+DFG K P+
Sbjct: 520 VCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGT---KFPV 576
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG 454
KW+APE Y K+S+KSD+W+FGIL+WE++S G+ PY ++VV V +G+R+ P
Sbjct: 577 KWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHL 636
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
Y++M + WH P RPTF + ++ +R+
Sbjct: 637 ASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLRE 671
Score = 44.8 bits (101), Expect = 0.006
Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 13/105 (12%)
Query: 52 NMTQWPWHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHTLCVRFR------GRVEH 104
N+ + W G ISR ++E LL +G F+VR S+ G +T+ + + G V+H
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGTVKH 348
Query: 105 YRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
Y V N +L + + FD++ LIH++ ++ G+ T+L
Sbjct: 349 YHVH-----TNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRL 388
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 188 bits (459), Expect = 2e-46
Identities = 111/291 (38%), Positives = 156/291 (53%), Gaps = 36/291 (12%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLG-ILN-----GTQKVAVKILKDREAASKFR--- 271
D +W+ L I + +G+GEFG V+ LN G VAVK LKD S+
Sbjct: 733 DPKWEFPRNRLIIEQTLGEGEFGKVLRAKALNISGQPGLTTVAVKTLKDDARESELNDLL 792
Query: 272 AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR------GR---- 320
+E ++ + H N++RLLG+ G L+ E GSL +YLR SR GR
Sbjct: 793 SEYQLLKEVSHPNVIRLLGVCTAPGGPIYLIIEFAEHGSLRNYLRRSRHLKSECGRLPSS 852
Query: 321 -------HY-------VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAK 366
HY VT ++FA+ C GM YL ++VHRDLAARNVL++A+ K
Sbjct: 853 TVDENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQICK 912
Query: 367 VADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSF 426
++DFG + ++P+KW APE+L + ++NKSD+WSFGIL+WE+ +
Sbjct: 913 ISDFGLTRDIYEDDAYFKRS--KGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTL 970
Query: 427 GRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
G PYP I + + + +GYRME P+ C P Y +MR+ WH DP RPTF
Sbjct: 971 GATPYPGIAVQNLFHLLRQGYRMERPDNCSPTLYNIMRSCWHIDPEQRPTF 1021
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 188 bits (457), Expect = 4e-46
Identities = 101/257 (39%), Positives = 142/257 (55%), Gaps = 8/257 (3%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLKH 282
W+I + + + E +G G+FG+V G NGT +VAVK LK + F EA +M + +H
Sbjct: 297 WEISKSSIVLIEKLGAGQFGEVWKGTWNGTTEVAVKTLKQGTMTKEDFLKEARIMRAAQH 356
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQ-INFAFDACCGME 340
LVRL + + +VTE GSLL YLR G++ + +NQ ++ GM
Sbjct: 357 PKLVRLYAVC--TEDPIYIVTELMCNGSLLQYLRDGPGKNLL--INQLVDMMAQIANGMA 412
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE++ +HRDLAARN+L+ KVADFG K PIKWTAPE
Sbjct: 413 YLEKEHYIHRDLAARNILVGENNCVKVADFGLARMVEDHYCTYMAQKS-TKFPIKWTAPE 471
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
A +F+ KSD+WSFGI+++E+ + G+VPYP + E + V GYRM P CP Y
Sbjct: 472 AALMGRFTIKSDVWSFGIVIYELITLGQVPYPSMNNTETLHQVSTGYRMPRPVNCPQPIY 531
Query: 461 ELMRAAWHADPASRPTF 477
+++ W + P RPTF
Sbjct: 532 DMLLRIWDSCPEKRPTF 548
Score = 52.8 bits (121), Expect = 2e-05
Identities = 42/107 (39%), Positives = 54/107 (50%), Gaps = 16/107 (14%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGR--------VEHYRV 107
W +SR+ +E LL G+ GVFLVRES G TL VR R V+HYR+
Sbjct: 179 WFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTVKHYRI 238
Query: 108 KWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVR-CL 153
K PD + +T F ++ +LI Y D+ GLC KL R CL
Sbjct: 239 K---HPDYRYYYITTKCS--FSSLQELIQFYSIDSHGLCCKLTRACL 280
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 186 bits (454), Expect = 9e-46
Identities = 110/260 (42%), Positives = 140/260 (53%), Gaps = 10/260 (3%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLKH 282
W+I L ++ +G G FG+V G G +VA+K +K + + F EA +M H
Sbjct: 255 WEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDH 314
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
NLV+L V T ++TE+ GSLL YLR+ G Q ++ A GM YL
Sbjct: 315 PNLVKLYA-VCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA-LVDMAAQIANGMMYL 372
Query: 343 ERQRVVHRDLAARNVL----ISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
E +++VHRDLAARNVL IS KVADFG AK PIKWTA
Sbjct: 373 EERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTG--AKFPIKWTA 430
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEA F+ KSD+WS+GILL+EI + G+VPYP + EVV VE GYRM P GCP
Sbjct: 431 PEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQ 490
Query: 459 PY-ELMRAAWHADPASRPTF 477
Y E++ W P RPTF
Sbjct: 491 IYEEVLLKCWDKTPDRRPTF 510
Score = 47.6 bits (108), Expect = 8e-04
Identities = 33/106 (31%), Positives = 50/106 (47%), Gaps = 12/106 (11%)
Query: 58 WHHGAISRERAEALLSGS--PDGVFLVRESTNFPGDHTLCVRFR------GRVEHYRVKW 109
W+ G I R RAE L+ S P G FL+RE + L +R G V+HY++K
Sbjct: 138 WYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKR 197
Query: 110 ATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+ +Q I F ++ +L+ +Y DGLC +L P+
Sbjct: 198 L----DHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPR 239
>UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep:
Zgc:153964 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 511
Score = 185 bits (451), Expect = 2e-45
Identities = 98/264 (37%), Positives = 143/264 (54%), Gaps = 8/264 (3%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAA--SKFRAEASVMASLK 281
W++ + + ++ +G G F DV G KVA+KILK+ +A +F+ E +M L+
Sbjct: 241 WELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILKNNDALVLREFQLEVQIMKRLR 300
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H++L+ L V TSS ++TE +G LL +LR+ + + I+ A GM Y
Sbjct: 301 HKHLISLFA-VCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDMAAQVADGMAY 359
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE +HRDLAARNVL+ K+ADFG K+P KWTAPEA
Sbjct: 360 LEANNSIHRDLAARNVLVGDGYVCKIADFGLARIIKEPVYLSD----DKKIPYKWTAPEA 415
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHV-ERGYRMEAPEGCPPGPY 460
+ + +S+KSD+WSFGILL+EI + G +PYP + EV + + YRM +P CP Y
Sbjct: 416 IGHGTYSSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDLITKENYRMPSPPKCPQAIY 475
Query: 461 ELMRAAWHADPASRPTFLHMRRNL 484
+MRA W + RP F ++ L
Sbjct: 476 NIMRACWRIESVDRPNFKVLKDEL 499
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 185 bits (451), Expect = 2e-45
Identities = 110/292 (37%), Positives = 154/292 (52%), Gaps = 28/292 (9%)
Query: 224 WKIDERDLEIRENIGKGEFGDV----MLGILNGTQK----VAVKILK---DREAASKFRA 272
W++D + E +G G FG V ++G+ G + VAVK L E F +
Sbjct: 11 WEVDYSSIAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLS 70
Query: 273 EASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS-----------RGR 320
E +M L KH N+V +LG V T +G CL+TE+C G L +YLR+ GR
Sbjct: 71 EIEMMKQLGKHLNIVSILGCV-THAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGR 129
Query: 321 ---HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
+TQ + ++FA GMEYL ++ VHRDLAARN+LI + K++DFG
Sbjct: 130 APGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVY 189
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
KLP+KW APEA+ N + KSD+W+FG++LWEI + G PYP
Sbjct: 190 ESSEYHKMHNT-GKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGK 248
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
E + ++ GYRME P+ C P Y +MR+ W + P RPTF +R L + D
Sbjct: 249 EFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQLMD 300
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 185 bits (450), Expect = 3e-45
Identities = 103/285 (36%), Positives = 149/285 (52%), Gaps = 12/285 (4%)
Query: 198 HAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-- 255
H Y + T ++ L+ + + RW++ D+ + + IG+G FGDV L ++
Sbjct: 899 HQYQSELPVTGRSGAVLR-KPVLRERWELSNDDVILLDKIGRGNFGDVYKAKLKSSKNTL 957
Query: 256 VAVKILK---DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
VAVK + E KF E ++ H N+V+L+G+ +V E A GSLL
Sbjct: 958 VAVKTCRMTLPEEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQP-IMIVMELVAGGSLL 1016
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
+LR + + Q + DA GM YLE + +HRDLAARN LI +E K++DFG
Sbjct: 1017 MFLR-KNASTLGQRQMMGMCRDAAAGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGM 1075
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYP 432
++PIKWTAPEAL + K+++ D+WS+GIL+WEI+S G PY
Sbjct: 1076 SREEEEYIVSGG----MKQIPIKWTAPEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYS 1131
Query: 433 RIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+ + ++ GYRM APEG PP Y LM W +P SRP F
Sbjct: 1132 GMSNSMARERIDEGYRMPAPEGAPPEMYRLMLKCWSYEPESRPHF 1176
>UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Ephrin
receptor - Apis mellifera (Honeybee)
Length = 996
Score = 183 bits (446), Expect = 9e-45
Identities = 110/303 (36%), Positives = 157/303 (51%), Gaps = 20/303 (6%)
Query: 192 AAGHFPHAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL- 250
A G +YV P D + +DA + + I IG GEFGDV G L
Sbjct: 600 AGGGGARSYVDPHTYEDPNQAVREFAREIDAGY------ITIEAIIGGGEFGDVCRGKLK 653
Query: 251 ---NGTQK--VAVKILKDR---EAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLV 302
+G + VA+K LK +A + F EAS+M +H N++ L G+V T S ++
Sbjct: 654 LPPDGRTEIDVAIKTLKPGSADKARNDFLTEASIMGQFEHPNVIFLQGVV-TKSNPVMII 712
Query: 303 TEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISA 361
TE GSL +LR+ G+ V QL + GM+YL VHRDLAARNVL++A
Sbjct: 713 TEFMENGSLDTFLRANDGKFQVLQL--VGMLRGIASGMQYLAEMNYVHRDLAARNVLVNA 770
Query: 362 EGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLW 421
K+ADFG K+P++WTAPEA+ + KF++ SD+WS GI+ W
Sbjct: 771 ALVCKIADFGLSREIESATEGAYTTRG-GKIPVRWTAPEAIAFRKFTSASDVWSMGIVCW 829
Query: 422 EIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMR 481
E+ S+G PY +V++ +E+GYR+ AP CP Y+LM W + RPTF ++
Sbjct: 830 EVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAIYQLMLDCWQKERTHRPTFANLT 889
Query: 482 RNL 484
+ L
Sbjct: 890 QTL 892
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 182 bits (443), Expect = 2e-44
Identities = 100/266 (37%), Positives = 142/266 (53%), Gaps = 11/266 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK---VAVKILKDREA---ASKFRAEASVMA 278
+I + +++ E IG GEFG V G+ N + +AVK LK + F EAS+M
Sbjct: 529 EIPPKYIKLVEEIGGGEFGTVYKGMWNERKPPVPIAVKTLKPGSSDKMRDDFLTEASIMG 588
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
H N+++L G++ T ++ E GSL YLR Q + A G
Sbjct: 589 QFHHPNVIKLYGVI-TKVEPAMIIMEFMDNGSLYYYLRHNDEKLSLQ-QLLKMACGVAAG 646
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M+YL VHRDLAARN+L+S + KVADFG K+P++WTA
Sbjct: 647 MQYLSEVGYVHRDLAARNILVSKDEVCKVADFGLSRETTNDEYDVKKG---GKIPVRWTA 703
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEA+ Y KF+ SD+WS+G+LLWE+ S+G+ PY V+ +E GYR++ P+ CP
Sbjct: 704 PEAISYRKFTTASDVWSYGVLLWEVMSYGQQPYEDWDNQMVLDKLESGYRLQKPKDCPST 763
Query: 459 PYELMRAAWHADPASRPTFLHMRRNL 484
YELM++ W A+ RPTF + R L
Sbjct: 764 VYELMQSCWSAEHTDRPTFKELVRLL 789
>UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: Eph
receptor - Manduca sexta (Tobacco hawkmoth) (Tobacco
hornworm)
Length = 1011
Score = 182 bits (443), Expect = 2e-44
Identities = 103/269 (38%), Positives = 144/269 (53%), Gaps = 13/269 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILN----GTQ-KVAVKILKD---REAASKFRAEASV 276
+ID + I IG GEFGDV G L G + VA+K LK A F AEAS+
Sbjct: 641 EIDASCITIEAIIGGGEFGDVCRGKLKLASCGQEIDVAIKTLKPGSTERARRDFLAEASI 700
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDA 335
M +H N++ L G+V T ++TE GSL +LR+ G+ V QL +
Sbjct: 701 MGQFEHPNVIFLQGVV-TKCNPIMIITEFMENGSLDTFLRANDGKFMVLQL--VGMLRGI 757
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM+YL +HRDLAARNVL+++ K+ADFG K+P++
Sbjct: 758 ATGMQYLSEMNYIHRDLAARNVLVNSHLVCKIADFGLSREIESTADGAYTTRG-GKIPVR 816
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
WTAPEA+ + KF++ SD+WS GI+ WE+ SFG PY +V++ +E+GYR+ AP C
Sbjct: 817 WTAPEAIAFRKFTSASDVWSMGIVCWEVMSFGERPYWNWSNQDVIKSIEKGYRLPAPMDC 876
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNL 484
P Y+LM W + RPTF + + L
Sbjct: 877 PEAVYQLMLDCWQKERTHRPTFASIVKTL 905
>UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1048
Score = 182 bits (443), Expect = 2e-44
Identities = 107/290 (36%), Positives = 157/290 (54%), Gaps = 12/290 (4%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILN--GTQK---VAVKILKDREAASK- 269
+++ +D +ID + I E IG GEFG+V LG + ++K VA+K LK + +
Sbjct: 628 ARAVLDFTKEIDASYIGIEEVIGGGEFGEVCLGRMRLPNSKKEHDVAIKTLKAGYSTQQK 687
Query: 270 --FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLN 327
F EAS+M H N++RL G+V T S ++TE+ GSL +LR + T +
Sbjct: 688 LDFLGEASIMGQFDHPNVIRLEGVV-TKSQPHMIITEYMENGSLDTFLRKHDGEF-TVIQ 745
Query: 328 QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXX 387
+ + GM+YL VHRDLAARN+L++A+ KV+DFG
Sbjct: 746 LVGILRNIAAGMKYLSDMGYVHRDLAARNILVNAQLICKVSDFGLSRVLEESSDSTYTTR 805
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
K+PI+WTAPEA+ Y KF++ SD+WS+GI++WE+ S+G PY + +V+ V GY
Sbjct: 806 G-GKIPIRWTAPEAINYRKFTSASDVWSYGIVMWEVMSYGERPYWGMSNQDVIHAVGTGY 864
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
R+ AP CP +ELM W D RP F + L D P QL++
Sbjct: 865 RLPAPMDCPQVQHELMLDCWKKDRNERPKFSQVVATL-DRMIREPEQLKV 913
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 182 bits (443), Expect = 2e-44
Identities = 96/257 (37%), Positives = 135/257 (52%), Gaps = 6/257 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILKDREAASK--FRAEASVMASL 280
+ I ++ I E IGKG FGDV G L +VAVK + + K F EA ++
Sbjct: 613 YNISHDNILIGEKIGKGNFGDVFKGYLKTHNMEVAVKSCRSEDFPDKQKFLQEAEILKQY 672
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
+H N+V L+G V ++ E A G+ L +LR + N +A GM
Sbjct: 673 RHPNIVELIG-VCAEKEPLYIIMELMAGGNFLSFLRGPEGKRLKVNNLTEMCVEAAAGMV 731
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
+LE++ +HRDLAARN L+ K++DFG Q +PIKWT+PE
Sbjct: 732 FLEQRNCIHRDLAARNCLVGDNNVLKISDFGMSREEDDGIYTVSSGLKQ--IPIKWTSPE 789
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
AL Y +++ +SD+WS+GILLWE Y++G PYP + E +E YRM PE CP Y
Sbjct: 790 ALNYGRYTTQSDVWSYGILLWETYTYGSGPYPGMNNRETRERIESNYRMPRPELCPHPVY 849
Query: 461 ELMRAAWHADPASRPTF 477
+LM + W DP RP+F
Sbjct: 850 KLMLSCWEYDPDKRPSF 866
Score = 36.7 bits (81), Expect = 1.5
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 57 PWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVK 108
PW+HG ISR+ A LL D FLVR S + +TL V+ G ++H+ ++
Sbjct: 516 PWYHGEISRQEATGLLKKMGD--FLVRYSAD-KEHYTLTVKMEG-IKHFIIQ 563
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 182 bits (443), Expect = 2e-44
Identities = 108/310 (34%), Positives = 165/310 (53%), Gaps = 29/310 (9%)
Query: 201 VAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK----- 255
++ A T G + + D +W+ L + + +G+G FG V++ G K
Sbjct: 339 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 398
Query: 256 ---VAVKILKD---REAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQ 308
VAVK+LKD + S +E +M + KH+N++ LLG T G ++ E+ ++
Sbjct: 399 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGAC-TQDGPLYVIVEYASK 457
Query: 309 GSLLDYLRSR---GRHYVTQLN-----QINFAFDACC------GMEYLERQRVVHRDLAA 354
G+L +YLR+R G Y +N Q+ F C GMEYL Q+ +HRDLAA
Sbjct: 458 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 517
Query: 355 RNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMW 414
RNVL++ K+ADFG +LP+KW APEAL ++++SD+W
Sbjct: 518 RNVLVTENNVMKIADFGLARDINNIDYYKKTT--NGRLPVKWMAPEALFDRVYTHQSDVW 575
Query: 415 SFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASR 474
SFG+L+WEI++ G PYP IP+ E+ + ++ G+RM+ P C Y +MR WHA P+ R
Sbjct: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
Query: 475 PTFLHMRRNL 484
PTF + +L
Sbjct: 636 PTFKQLVEDL 645
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 181 bits (441), Expect = 4e-44
Identities = 94/255 (36%), Positives = 137/255 (53%), Gaps = 6/255 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAAS-KFRAEASVMASLKH 282
W++ ++ +G G+FG V LG G VAVK++K+ + +F EA M L H
Sbjct: 365 WELKREEIVPLRELGSGQFGAVHLGKWKGLYDVAVKMIKEGVVSEDEFVEEAQTMMKLNH 424
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
LVRL G V + LV E+ GSLL YL+ G+ + L + +D C M +L
Sbjct: 425 PKLVRLYG-VCSKLYPIYLVMEYMPNGSLLSYLQIHGKE-LQPLQLLEICYDVCDAMAFL 482
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
E +++HRDLAARN L+ + T K++DFG K P+KW+APE
Sbjct: 483 ESCQLIHRDLAARNCLVDSNLTVKLSDFGMTKYVLDDLYVSSLGT---KFPVKWSAPEVF 539
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYEL 462
Y KFS+KSD+W+FGIL+WE+++ G+ PY +V+ V +GYR+ P+ Y++
Sbjct: 540 HYTKFSSKSDVWAFGILMWEVFTLGKQPYELYDNMQVIEKVSQGYRLYRPQLVSDITYQI 599
Query: 463 MRAAWHADPASRPTF 477
M WH P RP F
Sbjct: 600 MYNCWHELPEKRPAF 614
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 181 bits (440), Expect = 5e-44
Identities = 103/262 (39%), Positives = 140/262 (53%), Gaps = 13/262 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGIL----NGTQK--VAVKILK---DREAASKFRAEAS 275
+ID + I IG GEFGDV G L N Q VA+K LK +A F EAS
Sbjct: 735 EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
+M H N++ L G+V T S ++TE+ GSL +LR + T L I
Sbjct: 795 IMGQFDHPNVIYLQGVV-TRSNPVMIITEYMENGSLDTFLRVNDGKFQT-LQLIVMLRGI 852
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM YL VHRDLAARNVL++A+ K+ADFG K+P++
Sbjct: 853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG--GKIPVR 910
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
WTAPEA+ + KF++ SD+WS+G++LWE+ S+G PY +V++ +E+GYR+ AP C
Sbjct: 911 WTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDC 970
Query: 456 PPGPYELMRAAWHADPASRPTF 477
P Y+LM W RPTF
Sbjct: 971 PEALYQLMLDCWQKQRTHRPTF 992
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 181 bits (440), Expect = 5e-44
Identities = 98/264 (37%), Positives = 140/264 (53%), Gaps = 9/264 (3%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAA-SKFRAEASVMASLKH 282
W+ + + +G+G FG+V G+ G+ VA+K++K + E + L+H
Sbjct: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
Query: 283 ENLVRLLGLVFTSSGG--TCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
E L+RL + SGG +VTE +G+L +L + + + FA GM
Sbjct: 283 ERLIRLHAVC---SGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMS 339
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE QRVVHRDLAARNVL+ KVADFG +K+P+KWTAPE
Sbjct: 340 YLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSS---SKIPVKWTAPE 396
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
A Y FS KSD+WSFG+LL E++++G+ PY + E ++ + RGYR+ P CP Y
Sbjct: 397 AANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVY 456
Query: 461 ELMRAAWHADPASRPTFLHMRRNL 484
LM W + P RP+F +R L
Sbjct: 457 VLMLECWRSSPEERPSFATLREKL 480
Score = 48.4 bits (110), Expect = 5e-04
Identities = 30/106 (28%), Positives = 55/106 (51%), Gaps = 8/106 (7%)
Query: 53 MTQWPWHHGAISRERAEALLSGSPD--GVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWA 110
++ PW+ +SR +A+ LL P+ G FL+R S + G ++L VR + +V HYRV A
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMA 174
Query: 111 TAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVR-CLPK 155
+ L + F + +L+ +Y + + L++ C+P+
Sbjct: 175 A-----DGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQ 215
>UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack
CG14992-PA; n=1; Apis mellifera|Rep: PREDICTED: similar
to Ack CG14992-PA - Apis mellifera
Length = 1302
Score = 180 bits (439), Expect = 6e-44
Identities = 100/270 (37%), Positives = 151/270 (55%), Gaps = 12/270 (4%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQ----KVAVKILK-DREAA--SKFRAEASVMA 278
I ++D+ + + +G G FG V G VAVK+LK D + + F +E VM
Sbjct: 105 IQDKDVTLSDQLGDGSFGIVRRGEWTSPSGRKLPVAVKVLKADAQPSVIENFVSEVQVMH 164
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
+L H+NL+RL G+V + +VTE + G+LLDYLR + ++ L ++A G
Sbjct: 165 TLDHQNLIRLYGVVLSQP--MMMVTELASLGALLDYLRKQCGQ-ISVLTLCDYALQVATG 221
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YLE +R +HRDLA RNVL+S+ K+ DFG + K+P W A
Sbjct: 222 MAYLEAKRFLHRDLACRNVLLSSIDKVKIGDFGLMRALPQQEDCYVMSEHK-KVPFPWCA 280
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEGCPP 457
PE+LK KF++ SD+W FG+ LWE+ +FG P+ + +E++R +++ G R+ PE PP
Sbjct: 281 PESLKRRKFTHASDVWMFGVTLWEMLTFGEEPWVGLKGSEILRKIDKEGERLHEPEATPP 340
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADI 487
Y+LM W DP+ RPTF +R +L +
Sbjct: 341 EMYQLMLRCWACDPSERPTFASLRVSLTSM 370
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 180 bits (439), Expect = 6e-44
Identities = 98/260 (37%), Positives = 142/260 (54%), Gaps = 10/260 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
+I+ ++I + IG GEFG+V G + K VA+K LK + F AEAS+M
Sbjct: 409 EIEASRIKIEKIIGSGEFGEVCYGRMRLPGKRDIPVALKTLKVGYTEKQKRDFLAEASIM 468
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
A H N++RL G+V T S ++TE+ GSL +LR + T + +
Sbjct: 469 AQFDHPNVIRLEGVV-THSKPVMIITEYMENGSLDSFLRRHDGQF-TIIQLVGLLRGIAA 526
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YL +HRDLAARN+L+++ KV+DFG K+PI+WT
Sbjct: 527 GMTYLSDLGYIHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSG-GKIPIRWT 585
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ + KFS+ SD+WS+G+++WE+ S+G PY + +V++ VE GYR+ AP GCP
Sbjct: 586 APEAITFRKFSSSSDVWSYGVVMWEVTSYGERPYWNLTNRDVIKSVEEGYRLPAPMGCPA 645
Query: 458 GPYELMRAAWHADPASRPTF 477
+ LM W D RP F
Sbjct: 646 ALHTLMLDCWQKDRNERPRF 665
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 180 bits (438), Expect = 8e-44
Identities = 106/298 (35%), Positives = 158/298 (53%), Gaps = 16/298 (5%)
Query: 198 HAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-V 256
H + + T +T+ L+ D +W ++ D+ + ++IG+G FG+V G L V
Sbjct: 459 HLFNSHQTVTKRTEIVLKKPIPKD-KWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTPV 517
Query: 257 AVKILKDR---EAASKFRAEAS-VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
AVK ++ E +KF EA+ ++ H N+V+L+G V T ++ E G L
Sbjct: 518 AVKACRENLPAEHKNKFLMEAARILKQYDHPNIVKLIG-VCTQKQPIYIIMELVQGGDFL 576
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
+LR+ G H + I A + G+ YLE ++ +HRD+AARN L+ E K++DFG
Sbjct: 577 TFLRTEG-HNLKSSMLIRMAENVASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGM 635
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYN---KFSNKSDMWSFGILLWEIYSFGRV 429
Q +P+KWTAPEAL Y +++ +SD+WSFG+LLWE +S G
Sbjct: 636 SREEQDGVYSATGGMKQ--IPVKWTAPEALNYGSPGRYTTESDVWSFGVLLWETFSRGVT 693
Query: 430 PY--PRIPLAEVVR-HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
PY P + + R VERGYRM AP CP Y LM W DP RP+FL ++ +L
Sbjct: 694 PYTIPTVMSNQQTRDEVERGYRMPAPNNCPDEIYTLMCQCWQYDPRKRPSFLKLKADL 751
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 180 bits (438), Expect = 8e-44
Identities = 97/259 (37%), Positives = 135/259 (52%), Gaps = 10/259 (3%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-KVAVKILK---DREAASKFRAEASVMA 278
RW++ D+ + E IG+G FGDV L T+ VAVK + E KF E ++
Sbjct: 1055 RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
H N+V+L+G+ +V E GSLL YLR T+ Q+ DA G
Sbjct: 1115 QYDHPNIVKLIGICVQKQP-IMIVMELVLGGSLLTYLRKNSNGLTTR-QQMGMCRDAAAG 1172
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YLE + +HRDLAARN L+ E + K++DFG ++P+KWTA
Sbjct: 1173 MRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDG----MKQIPVKWTA 1228
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEAL + K+++ D+WS+GIL+WEI+S G PY + + ++ GYRM P+ P
Sbjct: 1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEE 1288
Query: 459 PYELMRAAWHADPASRPTF 477
Y LM W AD SRP F
Sbjct: 1289 MYRLMLQCWAADAESRPHF 1307
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 179 bits (436), Expect = 1e-43
Identities = 101/261 (38%), Positives = 139/261 (53%), Gaps = 12/261 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK----DREAASKFRAEASV 276
+ID + I IG GEFG+V G L K VA+K LK DR+ F EAS+
Sbjct: 582 EIDPSRIRIERVIGAGEFGEVCSGRLKTPAKKEIPVAIKTLKGGYVDRQRKD-FLREASI 640
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M H N++RL G+V T S +V E+ GSL +LR + T + +
Sbjct: 641 MGQFDHPNIIRLEGVV-TKSRPVMIVVEYMENGSLDSFLRKHDGQF-TVIQLVGMLRGIA 698
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
GM+YL VHRDLAARN+L+++ KV+DFG K+PI+W
Sbjct: 699 SGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTG-GKIPIRW 757
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
TAPEA+ + KFS+ SD WS+GI++WE+ S+G PY + +V+ +E GYR+ AP GCP
Sbjct: 758 TAPEAIAFRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCP 817
Query: 457 PGPYELMRAAWHADPASRPTF 477
++LM W D RP F
Sbjct: 818 VSLHQLMLHCWQKDRNIRPKF 838
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 179 bits (435), Expect = 2e-43
Identities = 105/299 (35%), Positives = 159/299 (53%), Gaps = 27/299 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVM----LGILN-GTQKV-AVKILKDREAASKFRAE 273
+D W++ L + + +G+GEFG V+ +GIL G Q V AVK+LK+ ++ A
Sbjct: 529 MDIDWEVPRESLSLGKVLGEGEFGKVVKAECIGILKPGLQSVVAVKMLKEGHTDAEMMAL 588
Query: 274 ASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR--GRHY----- 322
S M +K H N++ LLG T G ++ E+ G+L ++LR+ G Y
Sbjct: 589 VSEMEMMKMIGKHVNIINLLGCC-TQDGPLYVIVEYAPNGNLREFLRNHRPGNRYESPNE 647
Query: 323 -------VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXX 375
+TQ + ++F++ GMEYL +R +HRD AARNVL+S + K+ADFG
Sbjct: 648 DLKEKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIADFGLAKD 707
Query: 376 XXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIP 435
+ +LP++W APE+L + F+ ++D+WSFG+LLWEI + G PYP +P
Sbjct: 708 VHSNDYYRKKT--EGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVP 765
Query: 436 LAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQ 494
+ +H+ G+RME P C Y LMR W P RP+F + +L I T Q
Sbjct: 766 GQYMYQHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDLDKILTVTANQ 824
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 178 bits (433), Expect = 3e-43
Identities = 94/258 (36%), Positives = 140/258 (54%), Gaps = 11/258 (4%)
Query: 237 IGKGEFGDVMLGILNGTQK-----VAVKILKDREAASK---FRAEASVMASLKHENLVRL 288
+G+GEFG V G+L + +A+K L + F EASVM L+H +V+L
Sbjct: 664 LGRGEFGYVYQGLLRPQEPSDCTPIAIKQLVESTGKRNRVDFLREASVMIRLRHHCIVKL 723
Query: 289 LGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVV 348
+G+ +V E GS+LDY+ + +L + +A CGM+YLE+ V
Sbjct: 724 IGIC--KGPPLMMVEELVPLGSMLDYIIANKGTINPKLELVIWAAQIACGMQYLEQHHFV 781
Query: 349 HRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFS 408
HRDLAARN+L+++ AK++DFG K PIKW APE+ Y FS
Sbjct: 782 HRDLAARNILLASRNQAKISDFGLSRAIGAGDDYYRASQG-GKWPIKWYAPESFNYGTFS 840
Query: 409 NKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWH 468
+ SD+WSFG+ +WE+YS G PY + +V++ +E G R+ P+ CP +E+M+ W+
Sbjct: 841 HASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKLIENGQRLSQPDLCPENVFEVMKNCWN 900
Query: 469 ADPASRPTFLHMRRNLAD 486
+P SRPTF + R D
Sbjct: 901 YNPKSRPTFKFLTRFFTD 918
Score = 69.7 bits (163), Expect = 2e-10
Identities = 38/93 (40%), Positives = 53/93 (56%), Gaps = 5/93 (5%)
Query: 58 WHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQ 116
W HG ISRERAE +L +GVF+VREST+ GD L V F+ V HY+++
Sbjct: 9 WFHGKISRERAEEILRQEGGNGVFMVRESTSSEGDFVLSVLFQDEVVHYQIR----RHGD 64
Query: 117 NQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ +IDD + LI HY + ++GL T+L
Sbjct: 65 DAFFSIDDHMPIHGLDSLIEHYRESSNGLVTRL 97
Score = 36.3 bits (80), Expect = 1.9
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 7/72 (9%)
Query: 78 GVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHH 137
GV+LVR ST G L + + +H+ ++ + L IDD + ++ LI H
Sbjct: 331 GVYLVRYSTKH-GVDVLTLLYENEAKHFIIQ------RKQNYLYIDDGPYMTSLEHLIEH 383
Query: 138 YLQDADGLCTKL 149
Y + +DGL T L
Sbjct: 384 YTRFSDGLQTNL 395
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 178 bits (433), Expect = 3e-43
Identities = 98/263 (37%), Positives = 139/263 (52%), Gaps = 12/263 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGIL----NGTQKVAVKILKDREAA---SKFRAEASVM 277
++D + L + +G G FG V+ G+ N + VAVK LK+ + S+ EA +M
Sbjct: 351 ELDPKRLRLEHELGHGNFGSVVKGVYLLKNNKSVAVAVKTLKEEDIPGQKSEIVKEAEIM 410
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
+ L H N+VRL+G+ T S G LV E QG L +L+ V + + D
Sbjct: 411 SKLDHPNIVRLIGV--TQSPGFMLVMELAPQGPLHKFLKKNRNMNVLDILVLMLQVDE-- 466
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YLE Q VHRDLAARNVL+ +E K++DFG K P+KW
Sbjct: 467 GMNYLESQHFVHRDLAARNVLVVSENFVKISDFGMSRAMGVGNEYYRAERA-GKWPLKWY 525
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APE + Y+KFS+K D+WS+GI +WE S+G PY + +V +E GYR+ P+ C
Sbjct: 526 APECIYYHKFSSKGDVWSYGITMWEAVSYGGKPYQGMRGPVIVEKLESGYRLPKPDNCSD 585
Query: 458 GPYELMRAAWHADPASRPTFLHM 480
Y LM W +P RP+F+ +
Sbjct: 586 AVYTLMLKCWETNPDDRPSFMEI 608
Score = 56.8 bits (131), Expect = 1e-06
Identities = 36/100 (36%), Positives = 53/100 (53%), Gaps = 7/100 (7%)
Query: 55 QWPWHHGAISRERAEALLSG-SPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAP 113
Q PW HG I R AE L S G+FL+RE + G + + + ++G V HY +
Sbjct: 158 QQPWFHGVIPRTEAERRLKSLSETGMFLIRERGSPRGSYVIGLFYQGGVYHYLFE----S 213
Query: 114 DNQNQRLTIDDEEFFDNMTDLIHHYLQDADGL-CTKLVRC 152
+NQ Q L+I FDN+ +++ Y Q ++GL CT C
Sbjct: 214 NNQGQ-LSIKSGRSFDNLMAVVNFYSQKSEGLFCTLKRAC 252
Score = 44.4 bits (100), Expect = 0.007
Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 8/95 (8%)
Query: 58 WHHGAISRERAEALL---SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
W HG I+R+ AE L + DG +L+RES + G + L V +V HY ++ P
Sbjct: 9 WFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDKKVIHYAIQ--RQPS 66
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ I D F +L++H+ GL TKL
Sbjct: 67 GM---VGIADGPQFPGPVELVNHHKTSLGGLMTKL 98
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 177 bits (432), Expect = 4e-43
Identities = 108/298 (36%), Positives = 154/298 (51%), Gaps = 20/298 (6%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGIL---NGTQKV--AVKILKDREAASKFRAE----AS 275
+I++ +L + +G G FG V LG+ NG +V A+K LK E +AE A
Sbjct: 280 RIEDSELSTQGELGAGTFGTVRLGVYRPKNGEPEVQCALKYLKQSEELPNQKAEILREAD 339
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
MA+L H N+VRL G+ CLV E QG L +LR R V ++ +N A
Sbjct: 340 AMAALDHCNIVRLFGICVGDP--ICLVMELARQGPLNKFLRKRPTFPVIKI--LNMALQV 395
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM YLE R VHRDLAARNVL+ + K++DFG + P+K
Sbjct: 396 SRGMAYLEEVRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAETA-GRWPLK 454
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
W APE + Y KF +KSD+WS+G+ +WE +SFG PY + ++++ +E R+++PE C
Sbjct: 455 WYAPECIYYAKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQRLDSPEKC 514
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLWELSLVVSYDLEGARP 513
P Y++M W P RP+F + L DI + L + VVS DL+ P
Sbjct: 515 PQPIYDIMLRCWAWRPEDRPSFSELSSMLKDI------YVYLQQNDTVVSNDLKKPLP 566
Score = 59.7 bits (138), Expect = 2e-07
Identities = 36/102 (35%), Positives = 56/102 (54%), Gaps = 7/102 (6%)
Query: 50 LVNMTQWPWHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRV 107
+ ++++ W+HG ISR AE LL G G FLVR+S G++ L + F+G+ HY +
Sbjct: 1 MTDLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYII 60
Query: 108 KWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ PD + I D FD+ +LI ++ + DGL T L
Sbjct: 61 --SRHPDGS---VAIQDGAKFDSPIELIQYHTKKVDGLITTL 97
Score = 59.7 bits (138), Expect = 2e-07
Identities = 35/95 (36%), Positives = 51/95 (53%), Gaps = 8/95 (8%)
Query: 58 WHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W HGAISRE +E + G DG+FLVRE T LCV + + HY ++ T
Sbjct: 163 WFHGAISREESEQRMKAFGLRDGLFLVRERTEV-NSFALCVAVKNDIYHYLLEMNTLG-- 219
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
+L+I++ F+N+ ++ HY + DGL LV
Sbjct: 220 ---QLSIENGRKFENLLQVVDHYSRTPDGLLCTLV 251
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens
(Human)
Length = 822
Score = 177 bits (432), Expect = 4e-43
Identities = 105/307 (34%), Positives = 166/307 (54%), Gaps = 29/307 (9%)
Query: 204 AASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL--------NGTQK 255
++ T G + + D RW++ L + + +G+G FG V+L N K
Sbjct: 451 SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 510
Query: 256 VAVKILKD---REAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
VAVK+LK + S +E +M + KH+N++ LLG T G ++ E+ ++G+L
Sbjct: 511 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC-TQDGPLYVIVEYASKGNL 569
Query: 312 LDYLRSR---GRHYV--------TQLNQ---INFAFDACCGMEYLERQRVVHRDLAARNV 357
+YL++R G Y QL+ ++ A+ GMEYL ++ +HRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 358 LISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFG 417
L++ + K+ADFG +LP+KW APEAL ++++SD+WSFG
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFG 687
Query: 418 ILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+LLWEI++ G PYP +P+ E+ + ++ G+RM+ P C Y +MR WHA P+ RPTF
Sbjct: 688 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 747
Query: 478 LHMRRNL 484
+ +L
Sbjct: 748 KQLVEDL 754
>UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein
kinase protein; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to protein kinase protein - Nasonia vitripennis
Length = 1337
Score = 177 bits (431), Expect = 6e-43
Identities = 100/269 (37%), Positives = 144/269 (53%), Gaps = 14/269 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNG----TQKVAVKILK-----DREAASKFRAEASV 276
I ++D+ + +G G FG V G T VAVK+LK F +E
Sbjct: 134 IQDKDVTLSVKLGDGSFGVVRRGEWTSPTGRTLPVAVKVLKADALNQPNVVEDFVSEVQS 193
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M L H NL+RL G+V + +VTE G+LLDYLR + H ++ L N+A
Sbjct: 194 MHMLDHHNLIRLYGVVLSQP--MMMVTELAPLGALLDYLRKQCGH-ISVLTLCNYALQVA 250
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
GM YLE +R +HRDLA RNVL+S+ K+ DFG + K+P W
Sbjct: 251 TGMAYLEAKRFLHRDLACRNVLLSSVDKIKIGDFGLMRALPQQEDCYVMTEHK-KVPFPW 309
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEGC 455
APE+LK +FS+ SD+W FG+ LWE+ +FG P+ + +E+++ ++R G R+ PE
Sbjct: 310 CAPESLKARQFSHASDVWMFGVTLWEMLTFGEEPWVGLNGSEILKKIDREGERLHEPEAS 369
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNL 484
PP ++LM W DPA RPTF ++ +L
Sbjct: 370 PPAMFQLMLHCWARDPAERPTFASLKESL 398
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 177 bits (431), Expect = 6e-43
Identities = 106/299 (35%), Positives = 158/299 (52%), Gaps = 29/299 (9%)
Query: 215 QSQSFVDARWKIDERDLEIRENIGKGEFGDVM------LGILNGTQKVAVKILKDREAAS 268
Q S D +W+ L I + +G+GEFG V+ + G VAVK LK+ +AS
Sbjct: 485 QKSSPPDPKWEFPRSRLSIEQVLGEGEFGRVLRAKAQDIAGWQGQTTVAVKTLKEDASAS 544
Query: 269 KFR---AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR------SRG 319
+ +E ++ +H N++RLLG T+ G L+ E GSL +YLR S G
Sbjct: 545 ELADLLSEYQLLKEAQHPNVIRLLGACTTAGGPIYLIIEFAEFGSLRNYLRRSRHLESEG 604
Query: 320 R--------HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFG 371
R + +T + ++FA+ GM YL ++VHRDLAARNVL+ A K++DFG
Sbjct: 605 RPSIDPVVNYTITPRDILSFAWQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDFG 664
Query: 372 XXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPY 431
+ ++P+KW APE+L + +++KSD+WSFG+LLWE+ + G PY
Sbjct: 665 LTRDVYEDDAYLKRS--KGRVPVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPY 722
Query: 432 PRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF----LHMRRNLAD 486
P + + + ++ GYRME P C Y+LM + WH +P RP+F H R L D
Sbjct: 723 PGVDVHNLYNLLKAGYRMEKPANCSHQLYKLMVSCWHDEPGMRPSFKELTCHWERMLED 781
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 177 bits (430), Expect = 8e-43
Identities = 107/290 (36%), Positives = 151/290 (52%), Gaps = 25/290 (8%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDV-------MLGILNGTQKVAVKILK----DREAASK 269
++RW+ L ++ +G+G FG V + G T+ VAVK +K DRE
Sbjct: 912 ESRWEFPRDKLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDREKEDL 971
Query: 270 FRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR---SRGRHY--- 322
R E +M + H N+V LLG T L+ E+ G LL YLR +R Y
Sbjct: 972 VR-ELEIMQRVGSHPNVVTLLGCC-TEQEPHYLILEYVMYGKLLAYLRDHRTRQDFYNFS 1029
Query: 323 -----VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
+T + F + GMEYL ++++HRDLAARNVL+ K+ADFG
Sbjct: 1030 EDSAALTSRDLTVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSRFAN 1089
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
+ LPI+W APE+L Y+ F+ K+D+WSFGIL+WEI + G PYP +
Sbjct: 1090 EDGEVIETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMTAR 1149
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
EV+R V+ GYR+E P C + ++ WHADP RP F +RR+LA +
Sbjct: 1150 EVMRSVQSGYRLERPSHCRSELFRVIARCWHADPDRRPEFQLLRRDLAQL 1199
>UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep:
Ephrin receptor - Mus musculus (Mouse)
Length = 819
Score = 177 bits (430), Expect = 8e-43
Identities = 102/279 (36%), Positives = 147/279 (52%), Gaps = 11/279 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
+I+ + I IG GEFG+V G L K VA+K LK + F EAS+M
Sbjct: 485 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 544
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N++ L G+V T S +VTE+ GSL +L+ + T + +
Sbjct: 545 GQFDHPNIIHLEGVV-TKSKPVMIVTEYMENGSLDTFLKKNDGQF-TVIQLVGMLRGIAA 602
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM+YL VHRDLAARN+LI++ KV+DFG K+PI+WT
Sbjct: 603 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG-GKIPIRWT 661
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ + KF++ SD+WS+GI++WE+ S+G PY + +V++ VE GYR+ +P CP
Sbjct: 662 APEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 721
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
Y+LM W D SRP F + N+ D P+ L+
Sbjct: 722 ALYQLMLDCWQKDRNSRPKFDEI-VNMLDKLIRNPSSLK 759
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to protein tyrosine kinase - Nasonia
vitripennis
Length = 739
Score = 176 bits (429), Expect = 1e-42
Identities = 105/277 (37%), Positives = 148/277 (53%), Gaps = 15/277 (5%)
Query: 235 ENIGKGEFGDVMLGILN---GTQK-VAVKILKDRE---AASKFRAEASVMASLKHENLVR 287
E +G+GEFG V G+ + GTQ+ VA+K+L+D +F EA +M + H +V+
Sbjct: 468 EVLGEGEFGAVYEGLFDSPSGTQEPVAIKMLRDTHNIATREEFLREARLMMTFNHHCIVK 527
Query: 288 LLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRV 347
L+G F+ +V E + GS+L YL +A CGM+YLE R+
Sbjct: 528 LIG--FSEGPPLLMVQELVSLGSMLAYLLEFPDRINPNYELKVWASQIACGMKYLEEIRL 585
Query: 348 VHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKF 407
VHRDLAARN+L++++ AK++DFG K PIKW APE+ Y F
Sbjct: 586 VHRDLAARNILLASKHQAKISDFGLSRTFGSNDYYKATAG--GKWPIKWYAPESYNYGTF 643
Query: 408 SNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAW 467
S+ SD+WS+GI LWE++S+G PY EV+ VE+G R+ PE CP Y++M+ W
Sbjct: 644 SHASDVWSYGITLWEMFSYGEQPYGDRRGTEVIDLVEKGDRLAQPEQCPDHVYKVMQKCW 703
Query: 468 HADPASRPTFLHMRRNLADIRDHTPAQLQLWELSLVV 504
PA RPTF + L DI P + EL V
Sbjct: 704 SYSPADRPTF----QELLDIFSSDPEYANIRELVTAV 736
Score = 64.9 bits (151), Expect = 5e-09
Identities = 40/102 (39%), Positives = 57/102 (55%), Gaps = 9/102 (8%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W HG +SRE AE+LL G +G FLVRES++ GD+ L V G V HY+++
Sbjct: 9 WFHGNLSREDAESLLLEDGRDNGTFLVRESSSSLGDYVLSVLHDGEVAHYQIR----KHG 64
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL---VRCLP 154
++ +IDDE + LI +Y ++ D L T L +R LP
Sbjct: 65 EDAFFSIDDETTIHGLETLIEYYQKENDRLVTILQTPIRGLP 106
Score = 42.7 bits (96), Expect = 0.022
Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 8/95 (8%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W+HG + R A LL +G DG FLVR S G L V + H++++
Sbjct: 283 WYHGTLDRMEAINLLHKNGDLDGSFLVRLSERHDGIRVLTVMYNKTPYHFQIQ------K 336
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
+ L ID+ + ++ +I HY DGL L+
Sbjct: 337 RRNFLFIDNGPYLPSLEHVIEHYRCMPDGLPGPLI 371
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta
cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence; n=18; Eumetazoa|Rep:
14 days pregnant adult female placenta cDNA, RIKEN
full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence - Mus musculus (Mouse)
Length = 386
Score = 176 bits (428), Expect = 1e-42
Identities = 104/307 (33%), Positives = 165/307 (53%), Gaps = 29/307 (9%)
Query: 204 AASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL--------NGTQK 255
++ T G + + D RW++ L + + +G+G FG V+L N K
Sbjct: 15 SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 74
Query: 256 VAVKILKD---REAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
VAVK+LK + S +E +M + KH+N++ LLG T G ++ E+ ++G+L
Sbjct: 75 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC-TQDGPLYVIVEYASKGNL 133
Query: 312 LDYLRSR---GRHYV--------TQLNQ---INFAFDACCGMEYLERQRVVHRDLAARNV 357
+YL++R G Y QL+ ++ A+ GMEYL ++ +HRDLAARN
Sbjct: 134 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNA 193
Query: 358 LISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFG 417
L++ + K+ADFG +LP+KW APEAL ++++SD+WSFG
Sbjct: 194 LVTEDNVMKIADFGLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFG 251
Query: 418 ILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+LLWEI++ G PYP +P+ E+ + ++ G+RM+ P C Y +MR WHA P+ RPTF
Sbjct: 252 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 311
Query: 478 LHMRRNL 484
+ +L
Sbjct: 312 KQLVEDL 318
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 176 bits (428), Expect = 1e-42
Identities = 103/269 (38%), Positives = 145/269 (53%), Gaps = 17/269 (6%)
Query: 231 LEIRENIGKGEFGDVMLG-----ILNGTQKVAVKILKDREAASKFR---AEASVMASL-K 281
L +++++G G FG V I T VAVK+LK+ + + E V+ + +
Sbjct: 387 LNLKDDLGSGAFGVVKKAELFDPISQTTSIVAVKMLKESASTEDEKDIIMELKVLYHVGE 446
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQL---NQINFAFDACCG 338
H N+V LG G L+ E+C +G+LL +LRS+ + L NQ+ A G
Sbjct: 447 HCNVVSFLG-ASVHKGKLHLIVEYCERGNLLQFLRSKRGDMKSPLSVQNQVAIASQVANG 505
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YL +R +HRDLAARNVLI+ + T KVADFG +LPIKW A
Sbjct: 506 MAYLASKRCIHRDLAARNVLITKDLTLKVADFGLARKMYSSVYRPSGK----RLPIKWMA 561
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PE + ++KSD+WSFGILLWEI + GR PYP V+R +E GYRM P+GCP
Sbjct: 562 PEGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDIENGYRMPQPDGCPDK 621
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLADI 487
Y +M+ W +P +RP F + +L ++
Sbjct: 622 LYSVMKCCWQMNPIARPEFTELTNSLDNV 650
>UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1;
Girardia tigrina|Rep: Tyrosine-protein kinase SPK-1 -
Dugesia tigrina (Planarian)
Length = 497
Score = 176 bits (428), Expect = 1e-42
Identities = 102/269 (37%), Positives = 148/269 (55%), Gaps = 12/269 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAA-SKFRAEASVMASLKHE 283
+I+ ++EI IG+G FG V + +VA K+L+ +A KF EA +M L+H
Sbjct: 214 EINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAKIMHKLRHR 273
Query: 284 NLVRLLGLVFTSSGGTCLV-TEHCAQGSLLDYLRSRGRHYVTQLNQ-INFAFDACCGMEY 341
+V LLG+ L+ E+ GSL +YL++ T LNQ ++ + GM Y
Sbjct: 274 KIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKK-TNLNQMVHMMAEISEGMAY 332
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE ++VVHRDL A N+L++ + T KVADFG + P KWTAPEA
Sbjct: 333 LESEKVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTL--RFPYKWTAPEA 390
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG------C 455
K F++KSD+WS+GI+++EI ++ PYP IP EV+ V +GYRM PE C
Sbjct: 391 AKSKVFTSKSDVWSYGIVMFEILTWASSPYPDIPAKEVIEKVSKGYRMPNPEKFITGVCC 450
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNL 484
P Y++M W A+P RPTFL ++ +
Sbjct: 451 PDEIYKIMIWCWDANPEKRPTFLVLQEKM 479
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 175 bits (427), Expect = 2e-42
Identities = 109/308 (35%), Positives = 165/308 (53%), Gaps = 31/308 (10%)
Query: 204 AASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-------- 255
AA+T G + + D W++ L + + +G+G FG V+L G K
Sbjct: 321 AATTTILPGVSEYELPYDPVWELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTK 380
Query: 256 VAVKILKDREAASKFRA----EASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGS 310
VAVK+LK +A K RA E +M + KH+N++ LLG T G ++ E+ ++G+
Sbjct: 381 VAVKMLK-ADATEKDRADLISEMEMMKMIGKHKNIINLLGAC-TQDGPLYVLVEYASKGN 438
Query: 311 LLDYLRSR---GRHYVTQ-----------LNQINFAFDACCGMEYLERQRVVHRDLAARN 356
L DYLR+R G Y + + ++ A+ GM YL ++ +HRDLAARN
Sbjct: 439 LRDYLRARRPAGLEYWSSSRPVSLASMEIMELVSAAYQVARGMAYLASKKCIHRDLAARN 498
Query: 357 VLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSF 416
VL++ + K+ADFG +LP+KW APEAL ++++SD+WSF
Sbjct: 499 VLVTEDNVMKIADFGLARDVHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSF 556
Query: 417 GILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPT 476
G+LLWEI++ G PYP +P+ E+ + ++ G+RME P Y +MR WHA PA RPT
Sbjct: 557 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMEKPPTSTQELYLMMRGCWHAVPARRPT 616
Query: 477 FLHMRRNL 484
F + +L
Sbjct: 617 FQQLVEDL 624
>UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep:
CG14992-PA - Drosophila melanogaster (Fruit fly)
Length = 1073
Score = 175 bits (427), Expect = 2e-42
Identities = 102/274 (37%), Positives = 148/274 (54%), Gaps = 17/274 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQK-----VAVKILKDREAASK-----FRAEAS 275
I E+D+ + +G G FG V G + + VAVK+LK F E
Sbjct: 118 IHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQ 177
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI-NFAFD 334
M +L H NLVRL G+V + ++TE +GSLLD LR + RH T L I N++
Sbjct: 178 AMHALDHANLVRLYGVVLSQP--MMMITELAERGSLLDTLRKQCRH--TSLTIIWNWSVQ 233
Query: 335 ACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPI 394
GM YLE++R +HRDLA RNVL++A K+ DFG + K+P
Sbjct: 234 IVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHK-KVPF 292
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPE 453
W APE+L++ +FS+ SD W FG+ LWE++SFG P+ + ++++R ++R G R+ P+
Sbjct: 293 PWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPD 352
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
CPP Y +M W PA RPTF ++ LA +
Sbjct: 353 ACPPDVYAMMLQCWDKTPAERPTFAALKEYLASM 386
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 175 bits (426), Expect = 2e-42
Identities = 99/267 (37%), Positives = 141/267 (52%), Gaps = 12/267 (4%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQ---KVAVKILKD---REAASKFRAEASVMAS 279
ID +E IG+GEFG V+ G KVA+K L + +F EA VM
Sbjct: 558 IDASLIERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCG 617
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGM 339
L H +V+L+G+ LV E +QG+LLD+L++ +T + +A GM
Sbjct: 618 LDHPCIVKLMGVCLGPP--MMLVQELVSQGALLDFLQNDS---ITASDLKLWATQIASGM 672
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
YLE ++ VHRDLAARN+L+ +G AK++DFG + P+KW AP
Sbjct: 673 MYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTG-GRWPVKWYAP 731
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGP 459
E++ Y FS+ SD+W FG+ LWE+ S G PY AEV++ +E G+R+ PEGCP
Sbjct: 732 ESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNV 791
Query: 460 YELMRAAWHADPASRPTFLHMRRNLAD 486
Y++M W P +RPTF + D
Sbjct: 792 YQIMNKCWSYKPCNRPTFSQLNDMFRD 818
Score = 58.8 bits (136), Expect = 3e-07
Identities = 34/100 (34%), Positives = 54/100 (54%), Gaps = 8/100 (8%)
Query: 57 PWHHGAISRERA-EALLS-GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW HG++ R++A E++ G+ DG FL+R S N P L + G V ++ + +
Sbjct: 350 PWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEI------N 403
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLP 154
+ + IDD +FD + LI HY + DGL T L+ +P
Sbjct: 404 TKMESFYIDDGPYFDTLEQLIDHYSRYDDGLPTMLLHPIP 443
Score = 56.8 bits (131), Expect = 1e-06
Identities = 32/94 (34%), Positives = 53/94 (56%), Gaps = 7/94 (7%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W HG I+R+ A +L +GS +G FLVREST+ GD+ + + G +H++++
Sbjct: 76 WFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLPQHFQIQCM----- 130
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
+ ID+ F + LI++Y ++GL TKL
Sbjct: 131 GDFYYKIDNGPLFQGLDQLINYYRMGSNGLPTKL 164
>UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55;
Euteleostomi|Rep: Tyrosine-protein kinase ZAP-70 - Homo
sapiens (Human)
Length = 619
Score = 175 bits (426), Expect = 2e-42
Identities = 129/448 (28%), Positives = 200/448 (44%), Gaps = 36/448 (8%)
Query: 57 PWHHGAISRERAEA-LLSGSP-DGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW+H +++RE AE L SG+ DG FL+R G + L + + V HY +
Sbjct: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLIS-----Q 215
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPKXXXXXXXXXXXXXXXXXXX 174
++ + I + FD + L+ + ADGL + CL +
Sbjct: 216 DKAGKYCIPEGTKFDTLWQLVEYLKLKADGL----IYCLKEACPNSSASNASGAAAPTLP 271
Query: 175 XXXXXXXXXXXSVPSALAAGHFPHAYVAPAASTDQT-----DGTLQSQSFVDARWKIDER 229
+ + + G+ P A S D+ D ++ + D D++
Sbjct: 272 AHPSTLTHPQRRIDTLNSDGYTPEP--ARITSPDKPRPMPMDTSVYESPYSDPEELKDKK 329
Query: 230 DLEIRENI-------GKGEFGDVMLGILNGTQK---VAVKILK---DREAASKFRAEASV 276
R+N+ G G FG V G+ +K VA+K+LK ++ + EA +
Sbjct: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M L + +VRL+G+ + LV E G L +L + R + N
Sbjct: 390 MHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVS 446
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
GM+YLE + VHRDLAARNVL+ AK++DFG K P+KW
Sbjct: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA-GKWPLKW 505
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
APE + + KFS++SD+WS+G+ +WE S+G+ PY ++ EV+ +E+G RME P CP
Sbjct: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565
Query: 457 PGPYELMRAAWHADPASRPTFLHMRRNL 484
P Y LM W RP FL + + +
Sbjct: 566 PELYALMSDCWIYKWEDRPDFLTVEQRM 593
Score = 34.3 bits (75), Expect = 7.8
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 7/91 (7%)
Query: 57 PWHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
P+ +G+ISR AE L+G DG+FL+R+ G + L + R H+ ++
Sbjct: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE-----R 63
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGL 145
N I + +L Y +D DGL
Sbjct: 64 QLNGTYAIAGGKAHCGPAELCEFYSRDPDGL 94
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 175 bits (425), Expect = 3e-42
Identities = 98/274 (35%), Positives = 144/274 (52%), Gaps = 13/274 (4%)
Query: 211 DGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILN----GTQKVAVKILKDREA 266
D + Q FV +ID + ++ IG GEFG+V G++ G VA+K LK +
Sbjct: 665 DPNIAIQKFVT---EIDPSAISKQKVIGVGEFGEVFRGVMKTRGQGEVNVAIKTLKPGYS 721
Query: 267 ASK---FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYV 323
+ F +EAS+M H N++ L G+V T +VTE+ G+L YL+ R +
Sbjct: 722 EKQRLDFLSEASIMGQFSHPNIIHLEGVV-TKFKHIMIVTEYMDNGALDTYLKGRDGE-I 779
Query: 324 TQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXX 383
+ GM+YL VHRDLAARN+L+++ KV+DFG
Sbjct: 780 PPYQLVGMLRGIAAGMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDDEGT 839
Query: 384 XXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHV 443
K+PI+WTAPEA+ Y KF++ SD+WSFGI++WE+ +FG PY + EV++ +
Sbjct: 840 YTTRG-GKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAI 898
Query: 444 ERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+R+ AP CP Y+LM W D + RP F
Sbjct: 899 NEAFRLPAPMDCPSAIYQLMLQCWQHDRSKRPRF 932
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 175 bits (425), Expect = 3e-42
Identities = 98/259 (37%), Positives = 140/259 (54%), Gaps = 13/259 (5%)
Query: 229 RDLEIRENIGKGEFGDVMLGIL---NGTQK-VAVKILKDREAA---SKFRAEASVMASLK 281
+D+ E +G+G FG V G L NG + VAVK LK+ +A + F+ E +++ LK
Sbjct: 372 QDVRFVEELGEGAFGKVYKGELTQKNGERIFVAVKALKENASAKTQADFKREIELISDLK 431
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA---CCG 338
H+N+V +LG+V C++ E+ AQG L ++L + + L+Q+ F A C G
Sbjct: 432 HDNIVCILGVVLKEEP-LCMLFEYMAQGDLHEFLIANSPNEGKSLSQLQFLLIAQQICDG 490
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
MEYL VHRDLAARN L+ T K++DFG ++ LP++W
Sbjct: 491 MEYLASHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYSSDYYRVQS--KSLLPVRWMP 548
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
E++ Y KF+ +SD+WSFG++LWEIYS+G PY EV+ V + PE CP
Sbjct: 549 SESILYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQLLPCPESCPSA 608
Query: 459 PYELMRAAWHADPASRPTF 477
Y LM WH RPTF
Sbjct: 609 VYSLMVECWHEQAVRRPTF 627
>UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1002
Score = 175 bits (425), Expect = 3e-42
Identities = 104/279 (37%), Positives = 156/279 (55%), Gaps = 12/279 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLG-ILNG--TQKVAVKILKDREAA---SKFRAEASVMA 278
+ID+ ++I IG+GEFG+V G +L G T VAVK LK + + F EA MA
Sbjct: 609 EIDQTRIKIDSVIGRGEFGEVCRGKMLTGKTTTSVAVKRLKHGASLIDHTNFLREACTMA 668
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDACC 337
K N+++L G+V T S ++TE GSL +L++R G+ V QL +
Sbjct: 669 QFKDPNIIQLKGVV-TKSIPAMIITEFMEHGSLDKFLQARSGQPTVLQL--LEMLRGIAS 725
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM+YL + VHRDLAARN+L++++ KV+DFG K+ ++WT
Sbjct: 726 GMKYLSSMKYVHRDLAARNILVNSQLVCKVSDFGLSRTLENDPQATYTTQG-GKIALRWT 784
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APE+++ +F++ SD+WS+GI++WE+ S+G PY + V +E GYR+ +PEGCP
Sbjct: 785 APESIRCRQFTSASDVWSYGIVMWEVMSYGEKPYWDMSNEVVTEVLEDGYRLPSPEGCPT 844
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
+ LM W +P RPT L + + L D P+ LQ
Sbjct: 845 PVHSLMLKCWSYEPKRRPTLLEIIKTL-DHFIKQPSSLQ 882
>UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111;
Euteleostomi|Rep: Focal adhesion kinase 1 - Homo sapiens
(Human)
Length = 1052
Score = 175 bits (425), Expect = 3e-42
Identities = 94/278 (33%), Positives = 147/278 (52%), Gaps = 13/278 (4%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGIL----NGTQKVAVKILKDREAAS---KFRAEASV 276
++I +E+ IG+G+FGDV GI N VA+K K+ + S KF EA
Sbjct: 415 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 474
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M H ++V+L+G++ + ++ E C G L +L+ R ++ + + I +A+
Sbjct: 475 MRQFDHPHIVKLIGVI--TENPVWIIMELCTLGELRSFLQVR-KYSLDLASLILYAYQLS 531
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
+ YLE +R VHRD+AARNVL+S+ K+ DFG + KLPIKW
Sbjct: 532 TALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKAS---KGKLPIKW 588
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
APE++ + +F++ SD+W FG+ +WEI G P+ + +V+ +E G R+ P CP
Sbjct: 589 MAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP 648
Query: 457 PGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQ 494
P Y LM W DP+ RP F ++ L+ I + AQ
Sbjct: 649 PTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 686
>UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC
2.7.10.2).; n=1; Xenopus tropicalis|Rep:
Tyrosine-protein kinase Tec (EC 2.7.10.2). - Xenopus
tropicalis
Length = 647
Score = 174 bits (424), Expect = 4e-42
Identities = 97/267 (36%), Positives = 142/267 (53%), Gaps = 8/267 (2%)
Query: 203 PAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK 262
P S +++ T S+ +W+I+ +L + +G G FG V LG KVA+K ++
Sbjct: 386 PVCSKNKSAPTTAGFSY--DKWEINPSELTFMKELGSGLFGVVRLGKWRAQYKVAIKAIR 443
Query: 263 DREAASK-FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRH 321
+ + + F EA VM L H LV+L G V T +VTE G LL+YLR R
Sbjct: 444 EGAMSEEDFIEEAKVMMKLTHLKLVQLYG-VCTQQRPIYIVTEFMEHGCLLNYLRQRHGQ 502
Query: 322 YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXX 381
+ + ++ D C M YLE+ +HRDLAARN L++ G KV+DFG
Sbjct: 503 FSPDI-LLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAGVVKVSDFGMTRYVLDDQY 561
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
AK P+KW+ PE Y++FS+KSD+WSFG+L+WE+++ G++P+ EVV
Sbjct: 562 TSSCG---AKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGKMPFESYSNVEVVE 618
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWH 468
V RG R+ P+ Y +M A WH
Sbjct: 619 MVTRGERLYRPKLATKIIYSVMVACWH 645
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 174 bits (424), Expect = 4e-42
Identities = 98/267 (36%), Positives = 144/267 (53%), Gaps = 10/267 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILN--GTQK--VAVKILKDREAASK---FRAEASVM 277
++D + + IG+GEFG+V G L G ++ VA+K LK + S+ F EA++M
Sbjct: 610 ELDVSCVTMENVIGEGEFGEVYRGSLRLPGKERIVVAIKTLKSTYSDSQWWNFLREATIM 669
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N+V L G+V T ++TE+ G+L +LR + + + +N
Sbjct: 670 GQFNHPNIVHLEGVV-TKRRPMMIITEYMENGALDTFLRENEEKF-SPVQLVNMLQGIAS 727
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YL VHRDLAARN+L++ KV+DFG K+PI+WT
Sbjct: 728 GMTYLSEHNYVHRDLAARNILVTRSLQCKVSDFGLSRILENDAEGTYETKG-GKIPIRWT 786
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ + F++ SD+WSFGI++WE+ SFG PY + EV++ +E GYR+ P CP
Sbjct: 787 APEAIAHRIFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSLEDGYRLPPPVDCPS 846
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNL 484
YELM++ W D RP F +R L
Sbjct: 847 ILYELMKSCWSHDRMRRPHFQEIRAQL 873
>UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 712
Score = 174 bits (424), Expect = 4e-42
Identities = 96/248 (38%), Positives = 135/248 (54%), Gaps = 10/248 (4%)
Query: 237 IGKGEFGDVMLGILN--GTQK--VAVKILKD---REAASKFRAEASVMASLKHENLVRLL 289
IG GEFG+V GIL G ++ VA+K LK + F +EAS+M H+N++RL
Sbjct: 358 IGAGEFGEVYRGILKVPGRKESAVAIKTLKPGYTEKQRQDFLSEASIMGQFAHQNIIRLE 417
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVH 349
G+V T ++TE+ G+L YLR + T + GM+YL VH
Sbjct: 418 GVV-TKFKHAMIITEYMENGALDRYLRDHDGEF-TSFQLVGMLRGIAAGMKYLSDMSYVH 475
Query: 350 RDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSN 409
RDLAARN+L++ KV+DFG K+PI+WTAPEA+ Y KF++
Sbjct: 476 RDLAARNILVNNTLECKVSDFGLSRVLEDDPEGTYTTSG-GKIPIRWTAPEAIAYRKFAS 534
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
SD+WSFGI++WE+ +FG PY + EV++ + +R+ AP CP Y+LM W
Sbjct: 535 ASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSAVYQLMLQCWLH 594
Query: 470 DPASRPTF 477
D A RP F
Sbjct: 595 DRAKRPRF 602
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep:
Eph receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 174 bits (424), Expect = 4e-42
Identities = 97/267 (36%), Positives = 140/267 (52%), Gaps = 11/267 (4%)
Query: 238 GKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVMASLKHENLVRLLG 290
G+GEFG+V G L K VA+K LK + F +EAS+M H N++RL G
Sbjct: 585 GRGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 644
Query: 291 LVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHR 350
+V T S ++TE G+L +LR + T + + GM+YL VHR
Sbjct: 645 VV-TKSRPVMIITEFMENGALDSFLRQNDGQF-TVIQLVGMLRGIAAGMKYLSEMNYVHR 702
Query: 351 DLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPIKWTAPEALKYNKFSN 409
DLAARN+L+++ KV+DFG K+P++WTAPEA+ Y KF++
Sbjct: 703 DLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTS 762
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
SD+WS+GI++WE+ SFG PY + +V+ +E+ YR+ P CP ++LM W
Sbjct: 763 ASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQK 822
Query: 470 DPASRPTFLHMRRNLADIRDHTPAQLQ 496
D SRP F + N D PA L+
Sbjct: 823 DRNSRPRFAEI-VNTLDKMIRNPASLK 848
>UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3;
Culicidae|Rep: Protein kinase protein - Aedes aegypti
(Yellowfever mosquito)
Length = 1081
Score = 174 bits (424), Expect = 4e-42
Identities = 105/271 (38%), Positives = 148/271 (54%), Gaps = 16/271 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILN--GTQ--KVAVKILKDREAASK-----FRAEASV 276
I E+D+ + +G G FG V G N G Q VAVKILK A F E
Sbjct: 114 IHEKDVTMSVKLGDGSFGVVRRGEWNAPGGQIVPVAVKILKADTLAQPGVIEDFFKEVQA 173
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI-NFAFDA 335
M +L H NLVRL G+V + +VTE A GSLLD LR + ++ T L I N++
Sbjct: 174 MHTLNHPNLVRLHGVVLSQP--MMMVTELAANGSLLDTLRKQCKN--TSLTTIWNWSVQV 229
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM YLE +R +HRDLA RNVL+++ K+ DFG + K+P
Sbjct: 230 ATGMAYLESKRFLHRDLACRNVLLASGNKIKIGDFGLMRALPQQEDCYVMTEHK-KVPFP 288
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEG 454
W APE+L+Y +FS+ SD W F + LWE+++FG P+ + ++++R ++R G R+ P+
Sbjct: 289 WCAPESLRYRQFSHASDTWMFAVTLWEMFTFGEDPWVGLNGSQILRKIDREGERLHHPDA 348
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLA 485
CPP Y+LM W PA RPTF ++ L+
Sbjct: 349 CPPDVYQLMLQCWDKSPAERPTFAAIKEFLS 379
>UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=22;
Euteleostomi|Rep: Ephrin type-A receptor 8 precursor -
Homo sapiens (Human)
Length = 1005
Score = 174 bits (424), Expect = 4e-42
Identities = 98/260 (37%), Positives = 139/260 (53%), Gaps = 10/260 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILN--GTQKV--AVKILK---DREAASKFRAEASVM 277
+I+ + I + IG G+ G+V G L G + V A+K LK F +EAS+M
Sbjct: 629 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 688
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N++RL G+V T +VTE+ GSL +LR+ + T + +
Sbjct: 689 GQFDHPNIIRLEGVV-TRGRLAMIVTEYMENGSLDTFLRTHDGQF-TIMQLVGMLRGVGA 746
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YL VHRDLAARNVL+ + KV+DFG K+PI+WT
Sbjct: 747 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG-GKIPIRWT 805
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ + FS+ SD+WSFG+++WE+ ++G PY + +V+ VE GYR+ AP GCP
Sbjct: 806 APEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 865
Query: 458 GPYELMRAAWHADPASRPTF 477
++LM WH D A RP F
Sbjct: 866 ALHQLMLDCWHKDRAQRPRF 885
>UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=103;
Euteleostomi|Rep: Ephrin type-A receptor 5 precursor -
Homo sapiens (Human)
Length = 1037
Score = 174 bits (424), Expect = 4e-42
Identities = 101/279 (36%), Positives = 147/279 (52%), Gaps = 11/279 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
+I+ + I IG GEFG+V G L K VA+K LK + F EAS+M
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 728
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N++ L G+V T S +VTE+ GSL +L+ + T + +
Sbjct: 729 GQFDHPNIIHLEGVV-TKSKPVMIVTEYMENGSLDTFLKKNDGQF-TVIQLVGMLRGISA 786
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM+YL VHRDLAARN+LI++ KV+DFG K+PI+WT
Sbjct: 787 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG-GKIPIRWT 845
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ + KF++ SD+WS+GI++WE+ S+G PY + +V++ VE GYR+ +P CP
Sbjct: 846 APEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 905
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
Y+LM W + SRP F + N+ D P+ L+
Sbjct: 906 ALYQLMLDCWQKERNSRPKFDEI-VNMLDKLIRNPSSLK 943
>UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 7 SCAF14601, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 761
Score = 174 bits (423), Expect = 5e-42
Identities = 101/282 (35%), Positives = 152/282 (53%), Gaps = 13/282 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK----DREAASKFRAEASV 276
+ID ++I E IG GEFG+V G L K VA+K LK D++ F +EAS+
Sbjct: 403 EIDVSFVKIEEVIGAGEFGEVCRGRLKIPGKKENYVAIKTLKGGYTDKQRRD-FLSEASI 461
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M +H N++ L G++ T+S ++TE G+L +LR + T + +
Sbjct: 462 MGQFQHPNIIHLEGVI-TASCPVMILTEFMENGALDSFLRLNDSQF-TPIQLVGMLRGIA 519
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPIK 395
GM+YL VHRDLAARN+LI++ KV+DFG K+PI+
Sbjct: 520 SGMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIR 579
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
WTAPEA+ + KF++ SD+WS+GI++WE+ SFG PY + +V+ +E+ YR+ P C
Sbjct: 580 WTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDC 639
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
P ++LM W D ++RP F + L D PA L++
Sbjct: 640 PTHLHQLMLDCWQKDRSARPRFADLVSAL-DKLIRNPASLKI 680
>UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11;
Mammalia|Rep: Tyrosine-protein kinase 6 - Homo sapiens
(Human)
Length = 451
Score = 174 bits (423), Expect = 5e-42
Identities = 93/269 (34%), Positives = 136/269 (50%), Gaps = 7/269 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK--FRAEASVMASLK 281
W+ + + +G G FG+V G+ +VA+K++ + ++E M L+
Sbjct: 184 WERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 243
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H++++ L +V ++TE A+GSLL+ LR + ++ A+ GM Y
Sbjct: 244 HKHILALYAVVSVGDP-VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 302
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE Q +HRDLAARN+L+ KV DFG +P KWTAPEA
Sbjct: 303 LESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH----NIPYKWTAPEA 358
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
L +S KSD+WSFGILL E++S G+VPYP + E V+ GYRM P CPP ++
Sbjct: 359 LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 418
Query: 462 LMRAAWHADPASRPTFLHMRRNLADIRDH 490
LM W DP RP F +R L+ +
Sbjct: 419 LMLTCWCRDPEQRPCFKALRERLSSFTSY 447
Score = 42.3 bits (95), Expect = 0.030
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 57 PWHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW G ISR A L G+ G FL+R S D+ L VR V HY++ W A
Sbjct: 77 PWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKI-WRRA-- 133
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHY 138
RL +++ F ++ +L++++
Sbjct: 134 --GGRLHLNEAVSFLSLPELVNYH 155
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 174 bits (423), Expect = 5e-42
Identities = 100/290 (34%), Positives = 157/290 (54%), Gaps = 29/290 (10%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK--------VAVKILKD---REAASK 269
D RW+ L + + +G+G FG V++ G K VAVK+LKD + S
Sbjct: 467 DPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSD 526
Query: 270 FRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR---GRHY--- 322
+E +M + +H+N++ LLG T G ++ E+ ++G+L +YLR+R G Y
Sbjct: 527 LVSEMEMMKMIGRHKNIINLLGAC-TQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYD 585
Query: 323 --------VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
+T + ++ + GMEYL Q+ +HRDLAARNVL++ K+ADFG
Sbjct: 586 IARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLAR 645
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
+LP+KW APEAL ++++SD+WSFG+L+WEI++ G PYP I
Sbjct: 646 DVHNIDYYKKTT--NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 703
Query: 435 PLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
P+ E+ + ++ G+RM+ P C Y +M+ WHA + RPTF + +L
Sbjct: 704 PVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDL 753
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 174 bits (423), Expect = 5e-42
Identities = 115/302 (38%), Positives = 154/302 (50%), Gaps = 25/302 (8%)
Query: 197 PHAYVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVM---LGILNGT 253
P A S+ + ++ D RW+ L+ +G+G FG V +NG
Sbjct: 437 PGCLTGGAGSSGAPENAFAGEANCD-RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGN 495
Query: 254 Q---KVAVKILKDR--EAASK-FRAEASVMASLK-HENLVRLLGLVFTSSGGTCLVTEHC 306
+ VAVK LK+ E K +E VM SL+ H N+V LLG T T ++ E+
Sbjct: 496 EGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCC-TDKDPTFVILEYV 554
Query: 307 AQGSLLDYLRSRG--RHY---------VTQLNQINFAFDACCGMEYLERQRVVHRDLAAR 355
+G L YLRS RHY +T + +F + GM+YL + ++HRDLAAR
Sbjct: 555 NRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAAR 614
Query: 356 NVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWS 415
N+LI+ + T KVADFG + KLPI+W A E+L N FS KSD+WS
Sbjct: 615 NILITDDHTCKVADFGFARDVITSKIYERKS--EGKLPIRWMATESLYDNIFSVKSDIWS 672
Query: 416 FGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRP 475
FGIL+WEI + G PYP I A+V+R V GYR+E PE C Y +M W DP RP
Sbjct: 673 FGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERP 732
Query: 476 TF 477
F
Sbjct: 733 LF 734
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 173 bits (422), Expect = 7e-42
Identities = 93/226 (41%), Positives = 134/226 (59%), Gaps = 7/226 (3%)
Query: 255 KVAVKILKDREAASK-FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLD 313
+VAVK+L++ +++ F EA++M +H+ LV L G V + +V E+ ++GSLLD
Sbjct: 229 EVAVKMLREGTMSTQAFLQEAAIMKKFRHKRLVTLFG-VCSEHEPIYIVQEYMSKGSLLD 287
Query: 314 YLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX 373
+LR + + + AF GMEYLE ++++HRDLAARNVLI AK+ DFG
Sbjct: 288 FLRKDEGKELEFEDLVYIAFQVASGMEYLESKQLIHRDLAARNVLIGENNIAKICDFGLA 347
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
++ P+KWTAPEA+ Y KFS KSD+WS+GI L E++++G+VPYP
Sbjct: 348 RVIEDNEYCPKQG---SRFPVKWTAPEAIVYGKFSIKSDVWSYGIFLMELFTYGQVPYPG 404
Query: 434 IPLAEVVRHVERGYRMEAPEG--CPPGPYELMRAAWHADPASRPTF 477
+ EV+ VE+GYRM P P Y +M W A P +RPTF
Sbjct: 405 MHGREVIDMVEKGYRMGKPTSHVLPDEIYSIMLQCWDAKPENRPTF 450
Score = 39.9 bits (89), Expect = 0.16
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 58 WHHGAISRERAEALLSG--SPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W +SR+ AE LL +P G FLVR S + P ++L V+ + Y VK
Sbjct: 135 WFFENVSRKEAEKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEEIREYHVKHYKIKPL 194
Query: 116 QNQRLTIDDEEFFDNMTDLIHHY 138
N I + F + +L++ Y
Sbjct: 195 DNGGFYISTNKTFLTLVELVNAY 217
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 173 bits (422), Expect = 7e-42
Identities = 102/287 (35%), Positives = 156/287 (54%), Gaps = 28/287 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVM----LGILNGTQK--VAVKILKDREAASKFRAE 273
+D W+ID + I+E +G+G FG VM LG+ + + VAVK+LK ++
Sbjct: 323 IDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADL 382
Query: 274 ASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR----------- 318
S M ++K H+N++ L+G T +G +V E G+L +LR R
Sbjct: 383 LSEMDTMKNIGSHKNIINLIGAC-TQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRSRSD 441
Query: 319 -GRHYVTQL---NQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
H L + I+FAF GMEYL ++ +HRDLAARN+L+ + K+ADFG
Sbjct: 442 SSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLAR 501
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
+LPIKW A EAL ++ +SD+W+FGILLWEI++ G PYP I
Sbjct: 502 NVRDMDYYRKAT--DGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGI 559
Query: 435 PLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMR 481
P+ ++ ++ GYRM+ P+ CP Y++M + W+ +P +RP+F +R
Sbjct: 560 PVEKLFELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELR 606
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 173 bits (422), Expect = 7e-42
Identities = 102/287 (35%), Positives = 156/287 (54%), Gaps = 28/287 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVM----LGILNGTQK--VAVKILKDREAASKFRAE 273
+D W+ID + I+E +G+G FG VM LG+ + + VAVK+LK ++
Sbjct: 108 IDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADL 167
Query: 274 ASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR----------- 318
S M ++K H+N++ L+G T +G +V E G+L +LR R
Sbjct: 168 LSEMDTMKNIGSHKNIINLIGAC-TQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRSRSD 226
Query: 319 -GRHYVTQL---NQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
H L + I+FAF GMEYL ++ +HRDLAARN+L+ + K+ADFG
Sbjct: 227 SSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLAR 286
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
+LPIKW A EAL ++ +SD+W+FGILLWEI++ G PYP I
Sbjct: 287 NVRDMDYYRKAT--DGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGI 344
Query: 435 PLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMR 481
P+ ++ ++ GYRM+ P+ CP Y++M + W+ +P +RP+F +R
Sbjct: 345 PVEKLFELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELR 391
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 173 bits (422), Expect = 7e-42
Identities = 104/284 (36%), Positives = 151/284 (53%), Gaps = 29/284 (10%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNG--------TQKVAVKILKDREAASKFR 271
+D W+ L + + +G+G FG V+ G VAVK+LKD +
Sbjct: 688 LDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLA 747
Query: 272 AEASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG-------- 319
S M +K H+N++ LLG V T G ++ E A+G+L ++LR+R
Sbjct: 748 DLVSEMEVMKLIGRHKNIINLLG-VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSP 806
Query: 320 ---RHYVTQLN---QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX 373
R L+ ++ A+ GM+YLE ++ +HRDLAARNVL++ + K+ADFG
Sbjct: 807 DGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA 866
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
+LP+KW APEAL ++++SD+WSFGILLWEI++ G PYP
Sbjct: 867 RGVHHIDYYKKTS--NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 924
Query: 434 IPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
IP+ E+ + G+RM+ P CPP Y LMR WHA P+ RPTF
Sbjct: 925 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 968
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 173 bits (421), Expect = 9e-42
Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 11/270 (4%)
Query: 212 GTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL-NGTQKVAVKILK---DREAA 267
G L + RW+++ D+ + + IG+G FGDV L N VAVK + +
Sbjct: 520 GALLYKPIPRERWELNNDDVVLLDKIGRGNFGDVYRAQLKNSNDVVAVKTCRVTLPEDHK 579
Query: 268 SKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLN 327
KF E ++ H N+V+L+G+ +V E GSLL +LR + +T
Sbjct: 580 KKFLQEGRILKQYDHPNIVKLIGICVQKQP-IMIVMELVPGGSLLTFLRKKTA--LTDAQ 636
Query: 328 QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXX 387
+ DA GM YLE + +HRDLAARN L+ K++DFG
Sbjct: 637 LMKMCLDAAAGMRYLESKNCIHRDLAARNCLVGYNNVVKISDFGMSREEEEYIVSDG--- 693
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
++PIKWTAPEAL + K+++ D+WS+GIL WEI+S G PY + ++ ++ GY
Sbjct: 694 -MKQIPIKWTAPEALNFGKYTSLCDVWSYGILCWEIFSRGGTPYSGLSNSKAREKIDAGY 752
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
RM AP+ P Y LM W P +RP F
Sbjct: 753 RMPAPDNTPDEMYRLMLRCWEYKPENRPNF 782
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 173 bits (421), Expect = 9e-42
Identities = 97/270 (35%), Positives = 145/270 (53%), Gaps = 12/270 (4%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK----DREAA 267
+Q+ D +ID ++ I IG GEFG+V G L K VA+K LK D++
Sbjct: 708 NQAIRDFAKEIDASNIRIERVIGAGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRR 767
Query: 268 SKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLN 327
F +EAS+M H N++RL G+V T ++TE GSL +L+ + T +
Sbjct: 768 D-FLSEASIMGQFDHPNIIRLEGVV-TRCKPVMIITEFMENGSLDTFLKKHDGQF-TVIQ 824
Query: 328 QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXX 387
+ GM+YL VHRDLAARN+L+++ KV+DFG
Sbjct: 825 LVGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTR 884
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
K+PI+WTAPEA+ Y KF++ SD+WS+GI++WE+ S+G PY + +V++ ++ GY
Sbjct: 885 G-GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAIDEGY 943
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
R+ AP CP ++LM W + RP F
Sbjct: 944 RLPAPMDCPVVLHQLMLDCWEKGRSDRPKF 973
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 173 bits (420), Expect = 1e-41
Identities = 95/251 (37%), Positives = 131/251 (52%), Gaps = 8/251 (3%)
Query: 237 IGKGEFGDVMLG--ILNGTQKV--AVKILK---DREAASKFRAEASVMASLKHENLVRLL 289
IGKG FG V G + Q+V AVK L D E +F E +M S H N++ L+
Sbjct: 1063 IGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDLEEVEEFLREGILMKSFHHPNVLSLI 1122
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVH 349
G+ G +V G L ++RS R+ T + + F GMEYL ++ VH
Sbjct: 1123 GICLPQEGLPLVVLPFMKHGDLRHFIRSEERN-PTVKDLVGFGLQVSRGMEYLANRKFVH 1181
Query: 350 RDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSN 409
RDLAARN ++ KVADFG A+LP+KW A E+L+ KF+
Sbjct: 1182 RDLAARNCMLDESFHVKVADFGLARDVFDKEYYSVRRHKNARLPVKWMAMESLQTQKFTT 1241
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
KSD+WSFG+LLWE+ + G PYP + ++ R++ RG R+ PE CP Y LM + W+
Sbjct: 1242 KSDVWSFGVLLWELMTRGAPPYPDVDAYDITRYLFRGRRLAQPEYCPNPLYSLMLSCWNP 1301
Query: 470 DPASRPTFLHM 480
P RPTF +
Sbjct: 1302 QPVERPTFTQL 1312
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=8; Clupeocephala|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 714
Score = 172 bits (419), Expect = 2e-41
Identities = 107/283 (37%), Positives = 153/283 (54%), Gaps = 16/283 (5%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILN--GTQKV--AVKILK----DREAASKFRAEASV 276
+ID L+I E IG +FG+V G G ++V AVK L+ DRE F +EA V
Sbjct: 347 EIDPTHLKIEEVIGAAQFGEVSRGRYRPLGRREVLVAVKTLRWGASDREKGM-FLSEAGV 405
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGRHYVTQLNQINFAFDA 335
+ H N+++L G++ T + +VTE G L +LR + G+ V QL +
Sbjct: 406 LGQFDHPNVLKLEGVI-TRTPPERIVTEFMENGPLDSFLRENEGQFSVLQL--VGMLRGI 462
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ--AKLP 393
GM YL + VHRDLAARNVL+++ KV+DFG +K+P
Sbjct: 463 GAGMRYLAERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNIPTYTASLGSKIP 522
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
++WTAPEA ++ KFS+ SD+WSFG+L+WE+ S+G PY + EV++ V YR+ AP
Sbjct: 523 VRWTAPEAFQHRKFSSASDVWSFGVLMWEVMSYGERPYWDMSNQEVMKAVADQYRLPAPH 582
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
CPP + LM W AD RP F + +L + H PA L+
Sbjct: 583 SCPPALHSLMLQCWQADRGDRPAFETLLSSLDRLIRH-PASLK 624
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 172 bits (419), Expect = 2e-41
Identities = 107/293 (36%), Positives = 152/293 (51%), Gaps = 23/293 (7%)
Query: 234 RENI-GKGEFGDVMLGI--------LNGT---QKVAVKIL---KDREAASKFRAEASVMA 278
+ENI GKG FG V G LNG +KVA+K L +D E+ KF E +M+
Sbjct: 146 KENIIGKGHFGTVYNGEYITSEISKLNGNPIKRKVAIKTLSKIEDTESVEKFLKEGLMMS 205
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
EN++ L+G+ + G +V + G LL ++R + T + + F AC G
Sbjct: 206 DFHDENVLTLIGISWDDDGAPMVVLPYMMHGDLLQFIRKPSNN-PTVKDLVGFGLQACKG 264
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YL QR VHRDLAARN +++ KVADFG ++P+KW A
Sbjct: 265 MCYLASQRFVHRDLAARNCMLNETYVVKVADFGLARDIYEKEYYKPHEHA-GRMPVKWMA 323
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
E+L+ F+ K+D+WSFGILLWE+ + G PYP + +VV ++ G R+ P+ CP
Sbjct: 324 LESLQQQTFTIKTDVWSFGILLWELLTRGVTPYPDVDAFDVVNYILDGRRLRQPQYCPDP 383
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLADIRD-----HTPAQLQLWELSLVVSY 506
YELM + WH P +RP F+ + R + I H P Q + SL V+Y
Sbjct: 384 LYELMLSCWHPLPETRPDFVTLVRKIEQIYGEIHGVHYPGS-QSYNYSLDVNY 435
>UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1006
Score = 172 bits (418), Expect = 2e-41
Identities = 103/288 (35%), Positives = 149/288 (51%), Gaps = 20/288 (6%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK----DREAASKFRAEASV 276
+ID + I IG GEFG+V G L K VA+K LK D++ F +EAS+
Sbjct: 655 EIDVSSIHIERVIGMGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRD-FLSEASI 713
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M H N++RL G+V T ++TE+ GSL +LR + T + +
Sbjct: 714 MGQFDHPNIIRLEGVV-TRCKPLMIITEYMENGSLDAFLRKHDGQF-TVIQLVGMLRGIA 771
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX--------XXXXXXXXXXXXXXX 388
GM+YL VHRDLAARN+L+++ KV+DFG
Sbjct: 772 SGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRENTGTYLSP 831
Query: 389 QAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR 448
K+PI+WTAPEA+ Y KF+ SD+WS+GI++WE+ S+G PY + +V++ +E GYR
Sbjct: 832 GGKIPIRWTAPEAIAYRKFTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEEGYR 891
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
+ AP CP ++LM W + A RPTF + N+ D P L+
Sbjct: 892 LPAPMDCPLVLHQLMLDCWERERAERPTFSQI-LNMLDKLIRNPGTLR 938
>UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:
ENSANGP00000009263 - Anopheles gambiae str. PEST
Length = 1306
Score = 172 bits (418), Expect = 2e-41
Identities = 101/275 (36%), Positives = 155/275 (56%), Gaps = 15/275 (5%)
Query: 233 IRENIGKGEFGDVMLGI-LNGTQK--VAVKIL-KDREAAS--KFRAEASVMASLKHENLV 286
+ + +G GEFG V G+ NG+++ VA+K L ++R ++ +F EA++M S++HEN+V
Sbjct: 122 VNKQLGTGEFGIVQQGVWTNGSERIQVAIKCLCRERMQSNPMEFLKEAAMMHSIEHENIV 181
Query: 287 RLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRH--YVTQLNQINFAFDACCGMEYLER 344
RL G+V + LVTE SLL+ L+ G ++T FA C GM YLE
Sbjct: 182 RLYGVVLDTES-LMLVTELAHLRSLLECLKDPGLRVSFLTVPTLCEFASQICNGMMYLEN 240
Query: 345 QRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX-QAKLPIKWTAPEALK 403
+R +HRDLAARN+L+ ++ K++DFG KLPI W APE +
Sbjct: 241 KRFIHRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECIN 300
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY--RMEAPEGCPPGPYE 461
+ +F++ SD+W+FG+ LWEI+S+G P+ + +++ ++ + R+E PE CP Y
Sbjct: 301 FLRFTHASDVWAFGVCLWEIFSYGFQPWAALTGHQILEAIDEPHYQRLEKPECCPKEYYA 360
Query: 462 LMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
LM W D A RP F + L DI+ P QL+
Sbjct: 361 LMLKCWQHDAAKRPKFSDIFLMLPDIK---PEQLK 392
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 172 bits (418), Expect = 2e-41
Identities = 102/307 (33%), Positives = 165/307 (53%), Gaps = 29/307 (9%)
Query: 204 AASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL--------NGTQK 255
++ T G + + D RW++ L + + +G+G FG V++ N K
Sbjct: 445 SSGTPMLSGLSEYELPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTK 504
Query: 256 VAVKILKD---REAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
VAVK+LK + S +E +M + KH+N++ LLG T G ++ E+ ++G+L
Sbjct: 505 VAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGAC-TQDGPLYVIVEYTSKGNL 563
Query: 312 LDYLRSR---GRHYV-------TQL----NQINFAFDACCGMEYLERQRVVHRDLAARNV 357
+YLR+R Y QL + ++ A+ GM+YL ++ +HRDLAARNV
Sbjct: 564 REYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNV 623
Query: 358 LISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFG 417
L++ + K+ADFG +LP+KW APEAL ++++SD+WSFG
Sbjct: 624 LVTEDNIMKIADFGLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFG 681
Query: 418 ILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+LLWEI++ G PYP +P+ E+ + ++ G+RM+ P C Y +M+ WHA P+ RPTF
Sbjct: 682 VLLWEIFTLGGSPYPGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTF 741
Query: 478 LHMRRNL 484
+ +L
Sbjct: 742 NQLVEDL 748
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 172 bits (418), Expect = 2e-41
Identities = 95/261 (36%), Positives = 139/261 (53%), Gaps = 10/261 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKD---REAASKFRAEASVM 277
+ID ++I + IG GEFG+V G L K VA+K LK + F +EAS+M
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM 674
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N++ L G+V T S ++TE GSL +LR + T + +
Sbjct: 675 GQFDHPNVIHLEGVV-TKSTPVMIITEFMENGSLDSFLRQNDGQF-TVIQLVGMLRGIAA 732
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPIKW 396
GM+YL VHRDLAARN+L+++ KV+DFG K+PI+W
Sbjct: 733 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 792
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
TAPEA++Y KF++ SD+WS+GI++WE+ S+G PY + +V+ +E+ YR+ P CP
Sbjct: 793 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP 852
Query: 457 PGPYELMRAAWHADPASRPTF 477
++LM W D RP F
Sbjct: 853 SALHQLMLDCWQKDRNHRPKF 873
>UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=51;
Euteleostomi|Rep: Ephrin type-A receptor 7 precursor -
Homo sapiens (Human)
Length = 998
Score = 172 bits (418), Expect = 2e-41
Identities = 95/260 (36%), Positives = 138/260 (53%), Gaps = 10/260 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
++D ++I IG GEFG+V G L K VA+K LK + F EAS+M
Sbjct: 627 ELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIM 686
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N+V L G+V T +V E G+L +LR + T + +
Sbjct: 687 GQFDHPNVVHLEGVV-TRGKPVMIVIEFMENGALDAFLRKHDGQF-TVIQLVGMLRGIAA 744
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YL VHRDLAARN+L+++ KV+DFG K+P++WT
Sbjct: 745 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTG-GKIPVRWT 803
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA++Y KF++ SD+WS+GI++WE+ S+G PY + +V++ +E GYR+ AP CP
Sbjct: 804 APEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPA 863
Query: 458 GPYELMRAAWHADPASRPTF 477
G ++LM W + A RP F
Sbjct: 864 GLHQLMLDCWQKERAERPKF 883
>UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2;
Sophophora|Rep: Tyrosine-protein kinase shark -
Drosophila melanogaster (Fruit fly)
Length = 939
Score = 171 bits (417), Expect = 3e-41
Identities = 97/277 (35%), Positives = 140/277 (50%), Gaps = 12/277 (4%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGIL--------NGTQKVAVKILKDREA-ASKFRAE 273
R+ I+ L + IG GEFG V G L +VA+K+L D + +F E
Sbjct: 654 RFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLRE 713
Query: 274 ASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAF 333
ASVM L+H+ +VRL+G+ +V E GS+L Y+ G +A
Sbjct: 714 ASVMMRLEHKCIVRLIGIA--KGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWAS 771
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
CGM YLE Q VHRDLAARN+L++A AK++DFG + P
Sbjct: 772 QIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQG-GRWP 830
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
I+W APE+ FS+ SD+WSFG+ +WE++S G PY I + ++ V+ G R+ P
Sbjct: 831 IRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPN 890
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
CP Y +M++ W P RPTF+++ A D+
Sbjct: 891 LCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDY 927
Score = 63.7 bits (148), Expect = 1e-08
Identities = 38/96 (39%), Positives = 55/96 (57%), Gaps = 7/96 (7%)
Query: 58 WHHGAISRERAEALLS-GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDNQ 116
W+HG +SRE A+ LL G DG FLVRES+ GD L + +G V HY+V+ +
Sbjct: 10 WYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVR---RHGGE 66
Query: 117 NQRLTIDDE---EFFDNMTDLIHHYLQDADGLCTKL 149
+ +IDD+ + + L+ +Y Q A+GL TKL
Sbjct: 67 DAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKL 102
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 171 bits (416), Expect = 4e-41
Identities = 96/248 (38%), Positives = 135/248 (54%), Gaps = 8/248 (3%)
Query: 237 IGKGEFGDVMLG--ILNGTQKV--AVKILK---DREAASKFRAEASVMASLKHENLVRLL 289
IGKG FG V G I ++ AVK L + + A F E +M L H N++ L+
Sbjct: 686 IGKGHFGVVYHGEYIDEDQNRIHCAVKSLSRITEVQEAEAFLREGLLMRGLHHPNVLALI 745
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVH 349
G+V G ++ + G LL ++RS R+ T + I+F GMEYL Q+ VH
Sbjct: 746 GIVLPPEGLPRVLLPYMRHGDLLRFIRSPQRN-PTVKDLISFGLQVARGMEYLAEQKFVH 804
Query: 350 RDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSN 409
RDLAARN ++ T KVADFG A+LP+KW A E+L+ +F+
Sbjct: 805 RDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRHARLPVKWMALESLQTYRFTT 864
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
KSD+WSFG+LLWE+ + G PYP I ++++ + +G R+ PE CP Y +M+ W
Sbjct: 865 KSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRLPQPEYCPNSLYMVMQRCWAV 924
Query: 470 DPASRPTF 477
DPA RPTF
Sbjct: 925 DPAVRPTF 932
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 171 bits (416), Expect = 4e-41
Identities = 99/278 (35%), Positives = 149/278 (53%), Gaps = 24/278 (8%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGI------LNGTQKVAVKILKDREAASKFRA-- 272
DA+W+ L++ +G+GEFG V+ G L G VAVK+LK + ++ A
Sbjct: 763 DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALL 822
Query: 273 -EASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR-----GRHYVTQ 325
E ++ + H N+++LLG TSS L+ E+ GSL YLR SR G +
Sbjct: 823 SEFQLLQEVSHPNVIKLLGAC-TSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADG 881
Query: 326 LNQIN------FAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+ +N FA+ C GM YL ++VHRDLAARNVL++ K++DFG
Sbjct: 882 VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYED 941
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
+ ++P+KW APE+L + +++KSD+WSFG+L WE+ + G PYP I +
Sbjct: 942 DAYLKRS--RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNL 999
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
++ GYRM+ PE C Y ++R W +P RP+F
Sbjct: 1000 WSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSF 1037
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 171 bits (416), Expect = 4e-41
Identities = 99/262 (37%), Positives = 143/262 (54%), Gaps = 10/262 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK---DREAASKFRAEASVMASLK 281
+ID + + I + IG+GEFG+V G + VA+K LK + + S F EAS+M
Sbjct: 640 EIDFKLVNIEQVIGRGEFGEVCKGTFFN-KCVAIKTLKVGYNTQERSDFLGEASIMGQFD 698
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDACCGME 340
H N++RL G+V T S ++TE GSL +LR++ G+ QL ++ + GME
Sbjct: 699 HPNVIRLEGVV-TKSRPLMIITEFMENGSLDAFLRNQEGKIPSAQLTEMLLSIAQ--GME 755
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ--AKLPIKWTA 398
YL VHRDLAARN+L+++ KV+DFG +PI+WT+
Sbjct: 756 YLSNMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEQLEEDDVAMYTTRGGMIPIRWTS 815
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PEA+ FS SD+WSFGI++WE+ SFG PY + +VV+ V+ GYR+ P CP
Sbjct: 816 PEAITMRTFSTSSDVWSFGIVMWEVMSFGERPYWEMSNQDVVQFVDSGYRLPPPCYCPRI 875
Query: 459 PYELMRAAWHADPASRPTFLHM 480
+ +M W D RP F H+
Sbjct: 876 IHSVMLECWKRDRTQRPNFSHL 897
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 171 bits (416), Expect = 4e-41
Identities = 96/264 (36%), Positives = 133/264 (50%), Gaps = 15/264 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVMA 278
++ L++ E I G FGDV G L Q VAVK LK + E KF E +M
Sbjct: 167 VERERLQLGEVITSGNFGDVYRGKLRSRQNTWHDVAVKSLKSLENHEDVEKFLREGVMMR 226
Query: 279 SLKHENLVRLLGL-----VFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAF 333
L H N++ L+G+ V ++ G L +LR G + +T L + F
Sbjct: 227 GLDHRNVLALIGVCVDGEVERLQTSPLIILPFMENGDLRTFLRD-GNNVLTVLKLLKFCK 285
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
D GMEYL ++ VHRDLAARN ++ KVADFG Q LP
Sbjct: 286 DVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVKVADFGLSRDLFDRDYYRSSVKTQ--LP 343
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
+KW PE++KY ++ KSD+WS+GI+ WEI + G +PYP + +++++ G RME PE
Sbjct: 344 LKWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGAIPYPTVQAVAILQYLSEGNRMERPE 403
Query: 454 GCPPGPYELMRAAWHADPASRPTF 477
CP Y+ M W D RPTF
Sbjct: 404 CCPHKLYKTMEKCWLDDTERRPTF 427
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 171 bits (415), Expect = 5e-41
Identities = 93/264 (35%), Positives = 139/264 (52%), Gaps = 8/264 (3%)
Query: 231 LEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVMASLKHE 283
+E R+ IGKG FG V G L + K AVK L D + F E +M H
Sbjct: 1065 IEDRQVIGKGHFGTVYHGYLIDSNKQETHCAVKSLNRITDLKDVDHFLREGLIMKGFDHP 1124
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
N++ LLG++ G +V + G + ++RS R+ T + I F GMEYL
Sbjct: 1125 NILSLLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRN-PTVKDLIGFGLQVAKGMEYLA 1183
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
+++ VHRDLAARN ++ T KVADFG Q KLP+KW A E+L+
Sbjct: 1184 QKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYYSIQDHKQVKLPVKWMAIESLQ 1243
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
KF++KSD+WS+GIL+WE+ + G PYP + ++ ++ +G R+ P+ CP Y +M
Sbjct: 1244 TQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNYLLKGRRLPQPQFCPNTLYSIM 1303
Query: 464 RAAWHADPASRPTFLHMRRNLADI 487
+ W +P RP+F + ++ I
Sbjct: 1304 LSCWDPEPDFRPSFSSLASDVQHI 1327
>UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 283
Score = 171 bits (415), Expect = 5e-41
Identities = 101/285 (35%), Positives = 149/285 (52%), Gaps = 20/285 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILKDREAASKFRA---EASVM 277
+I +E+ +G+GEFG V+ G + +GT+ AVK LK S ++ E +M
Sbjct: 1 QIPREAVELGRTLGEGEFGKVIEGNVTEPDGTRVHCAVKKLKRTATESDWKDLLNELDIM 60
Query: 278 ASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQ-------- 328
+ +H N+V L+G G ++ E C G+LL YL+ + L++
Sbjct: 61 VQVGEHPNIVNLIGACSDPEGPLMVIVEFCGNGNLLHYLQKNSNKNYSNLHEYVLTIPAR 120
Query: 329 --INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXX 386
+ A D GM +LE+ R VHRDLAARNVL+ TAKV+DFG
Sbjct: 121 ERLRIAADVASGMAHLEKMRCVHRDLAARNVLLDEALTAKVSDFGLSRDIYTNSVYEKTT 180
Query: 387 XXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG 446
KLP KW A E+++ +++ SD WSFG+LLWEI + G +PYP + E++ +++G
Sbjct: 181 G--GKLPAKWMAIESIEAGLYTSHSDAWSFGVLLWEIETGGCIPYPTFTVQEMLNSLKKG 238
Query: 447 YRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
YR+E P C Y LM + W ADPA RP F+ + L + D T
Sbjct: 239 YRLEKPPYCLEPLYTLMLSCWSADPALRPHFVEICARLKQLHDVT 283
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 171 bits (415), Expect = 5e-41
Identities = 106/302 (35%), Positives = 159/302 (52%), Gaps = 27/302 (8%)
Query: 213 TLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLG----IL---NGTQKVAVKILK--- 262
TL SQ+ +++ L + + +G G FG+V G IL +G +VAVK LK
Sbjct: 80 TLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGA 139
Query: 263 -DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRH 321
D+E S+F EA +M+ H ++++LLG+ + L+ E G LL YLR +
Sbjct: 140 TDQEK-SEFLKEAHLMSKFDHPHILKLLGVCLLNEP-QYLILELMEGGDLLSYLRGARKQ 197
Query: 322 -----YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEG------TAKVADF 370
+T + ++ D C G YLE+ R +HRDLAARN L+S + K+ DF
Sbjct: 198 KFQSPLLTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDF 257
Query: 371 GXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVP 430
G + LP++W APE+L F+N SD+W+FG+L+WE + G+ P
Sbjct: 258 GLARDIYKNDYYRKRG--EGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQP 315
Query: 431 YPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
YP + EV+ HV G R+E+P CP +LM W DP +RPTF +++ L +IR H
Sbjct: 316 YPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEIR-H 374
Query: 491 TP 492
+P
Sbjct: 375 SP 376
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 171 bits (415), Expect = 5e-41
Identities = 95/264 (35%), Positives = 138/264 (52%), Gaps = 8/264 (3%)
Query: 231 LEIRENIGKGEFGDVMLGIL--NGTQKV--AVKILK---DREAASKFRAEASVMASLKHE 283
+ E IG+G FG V G L N +K+ AVK L D S+F E +M H
Sbjct: 1078 VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 1137
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
N++ LLG+ S G +V + G L +++R+ H T + I F GM+YL
Sbjct: 1138 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE-THNPTVKDLIGFGLQVAKGMKYLA 1196
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
++ VHRDLAARN ++ + T KVADFG AKLP+KW A E+L+
Sbjct: 1197 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQ 1256
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
KF+ KSD+WSFG++LWE+ + G PYP + ++ ++ +G R+ PE CP YE+M
Sbjct: 1257 TQKFTTKSDVWSFGVVLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 1316
Query: 464 RAAWHADPASRPTFLHMRRNLADI 487
WH RP+F + ++ I
Sbjct: 1317 LKCWHPKAEMRPSFSELVSRISAI 1340
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 171 bits (415), Expect = 5e-41
Identities = 104/284 (36%), Positives = 150/284 (52%), Gaps = 29/284 (10%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNG--------TQKVAVKILKDREAASKFR 271
+D W+ L + + +G+G FG V+ G T VAVK+LKD +
Sbjct: 453 LDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLA 512
Query: 272 AEASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG-------- 319
S M +K H+N++ LLG V T G ++ E A+G+L ++LR+R
Sbjct: 513 DLVSEMEVMKLIGRHKNIINLLG-VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSP 571
Query: 320 ---RHYVTQLN---QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX 373
R L+ ++ A+ GM+YLE ++ +HRDLAARNVL++ + K+ADFG
Sbjct: 572 DGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLA 631
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
+LP+KW APEAL ++++SD+WSF ILLWEI++ G PYP
Sbjct: 632 RGVHHIDYYKKTS--NGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPG 689
Query: 434 IPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
IP+ E+ + G+RME P CP Y LMR WHA P+ RPTF
Sbjct: 690 IPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTF 733
>UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=19;
Mammalia|Rep: Ephrin type-A receptor 1 precursor - Homo
sapiens (Human)
Length = 976
Score = 171 bits (415), Expect = 5e-41
Identities = 104/295 (35%), Positives = 145/295 (49%), Gaps = 17/295 (5%)
Query: 200 YVAPAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILN----GTQK 255
YV A D G L +D W L + IG+GEFG+V G L +
Sbjct: 599 YVDLQAYEDPAQGALDFTRELDPAW------LMVDTVIGEGEFGEVYRGTLRLPSQDCKT 652
Query: 256 VAVKILKDREAASK---FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
VA+K LKD + F EA++M H +++ L G+V T ++TE G+L
Sbjct: 653 VAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVV-TKRKPIMIITEFMENGALD 711
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
+LR R V + GM YL VHRDLAARN+L++ KV+DFG
Sbjct: 712 AFLREREDQLVPG-QLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGL 770
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYP 432
K+PI+WTAPEA+ + F+ SD+WSFGI++WE+ SFG PY
Sbjct: 771 TRLLDDFDGTYETQG--GKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYG 828
Query: 433 RIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
+ EV++ +E GYR+ P CP YELM+ W D A RP F ++ +L +
Sbjct: 829 EMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQL 883
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 170 bits (414), Expect = 7e-41
Identities = 94/264 (35%), Positives = 133/264 (50%), Gaps = 8/264 (3%)
Query: 231 LEIRENIGKGEFGDVMLGIL----NGTQKVAVKILK---DREAASKFRAEASVMASLKHE 283
L + E IG+G FG V G L Q A+K L D E S+F E ++ H
Sbjct: 1079 LHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIVKDFSHP 1138
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
N++ LLG+ S G +V + G L +++R H T + + F GMEYL
Sbjct: 1139 NVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDES-HNPTVKDLMGFGLQVAKGMEYLA 1197
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
++ VHRDLAARN ++ T KVAD G KLP+KW A E+L+
Sbjct: 1198 SKKFVHRDLAARNCMLDESYTVKVADVGLARDVYDKEYYSVHNKHGVKLPVKWMALESLQ 1257
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
+KF+ KSD+WSFG+LLWE+ + G PY + ++ + +G R+ PE CP Y +M
Sbjct: 1258 THKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVM 1317
Query: 464 RAAWHADPASRPTFLHMRRNLADI 487
WH P RPTFL + ++ I
Sbjct: 1318 IECWHPKPERRPTFLELVSRISAI 1341
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 170 bits (414), Expect = 7e-41
Identities = 93/248 (37%), Positives = 134/248 (54%), Gaps = 8/248 (3%)
Query: 237 IGKGEFGDVMLG-ILNGTQ---KVAVKILK---DREAASKFRAEASVMASLKHENLVRLL 289
IGKG FG V G ++ Q + A+K L + + F E +M L H N++ L+
Sbjct: 1088 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 1147
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVH 349
G++ G ++ + G LL ++RS R+ T + I+F GMEYL Q+ VH
Sbjct: 1148 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRN-PTVKDLISFGLQVARGMEYLAEQKFVH 1206
Query: 350 RDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSN 409
RDLAARN ++ T KVADFG A+LP+KW A E+L+ +F+
Sbjct: 1207 RDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTT 1266
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
KSD+WSFG+LLWE+ + G PY I ++ + +G R+ PE CP Y++M+ W A
Sbjct: 1267 KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEA 1326
Query: 470 DPASRPTF 477
DPA RPTF
Sbjct: 1327 DPAVRPTF 1334
>UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23;
Theria|Rep: Tyrosine-protein kinase SYK - Homo sapiens
(Human)
Length = 635
Score = 170 bits (414), Expect = 7e-41
Identities = 103/254 (40%), Positives = 136/254 (53%), Gaps = 13/254 (5%)
Query: 231 LEIRENIGKGEFGDVMLG---ILNGTQKVAVKILK----DREAASKFRAEASVMASLKHE 283
LE +E +G G FG V G + + VAVKILK D + AEA+VM L +
Sbjct: 372 LEDKE-LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
+VR++G+ S LV E G L YL+ + RH V N I GM+YLE
Sbjct: 431 YIVRMIGICEAESW--MLVMEMAELGPLNKYLQ-QNRH-VKDKNIIELVHQVSMGMKYLE 486
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
VHRDLAARNVL+ + AK++DFG K P+KW APE +
Sbjct: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT-HGKWPVKWYAPECIN 545
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
Y KFS+KSD+WSFG+L+WE +S+G+ PY + +EV +E+G RM P GCP Y+LM
Sbjct: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605
Query: 464 RAAWHADPASRPTF 477
W D +RP F
Sbjct: 606 NLCWTYDVENRPGF 619
Score = 63.3 bits (147), Expect = 1e-08
Identities = 34/91 (37%), Positives = 50/91 (54%), Gaps = 8/91 (8%)
Query: 57 PWHHGAISRERAE--ALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW HG ISRE +E L+ +G FL+R N G + LC+ G+V HYR+
Sbjct: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRID-----K 220
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGL 145
++ +L+I + + FD + L+ HY ADGL
Sbjct: 221 DKTGKLSIPEGKKFDTLWQLVEHYSYKADGL 251
Score = 45.6 bits (103), Expect = 0.003
Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 7/91 (7%)
Query: 57 PWHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
P+ G I+RE AE L G DG++L+R+S N+ G L V + HY T
Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHY-----TIER 68
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGL 145
N I + DL H++ Q++DGL
Sbjct: 69 ELNGTYAIAGGRTHASPADLCHYHSQESDGL 99
>UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24;
Euteleostomi|Rep: Activated CDC42 kinase 1 - Homo
sapiens (Human)
Length = 1036
Score = 170 bits (414), Expect = 7e-41
Identities = 109/308 (35%), Positives = 156/308 (50%), Gaps = 19/308 (6%)
Query: 202 APAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNG----TQKVA 257
+PA +G LQS + + I E+DL + E +G G FG V G + T VA
Sbjct: 102 SPAPGGPAGEGPLQSLTCL-----IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVA 156
Query: 258 VKILK-----DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
VK LK EA F E + M SL H NL+RL G+V T +VTE GSLL
Sbjct: 157 VKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP--MKMVTELAPLGSLL 214
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
D LR H++ +A GM YLE +R +HRDLAARN+L++ K+ DFG
Sbjct: 215 DRLRKHQGHFLLGTLS-RYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGL 273
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYP 432
+ K+P W APE+LK FS+ SD W FG+ LWE++++G+ P+
Sbjct: 274 MRALPQNDDHYVMQEHR-KVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWI 332
Query: 433 RIPLAEVVRHVER-GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
+ ++++ +++ G R+ PE CP Y +M W P RPTF+ +R L + +
Sbjct: 333 GLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 392
Query: 492 PAQLQLWE 499
LQ +E
Sbjct: 393 MRALQDFE 400
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 170 bits (413), Expect = 9e-41
Identities = 103/278 (37%), Positives = 146/278 (52%), Gaps = 19/278 (6%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVM----LGI--LNGTQKVAVKILKDREAASK 269
+Q+ + +W+ L++ +G+G FG V L I +G VAVK LK+ +
Sbjct: 344 AQNKQEDKWEFPRHRLKVFNILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATERE 403
Query: 270 ---FRAEASVMASLK-HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS------RG 319
E VM +L H N+VRLLG T ++ E+ + G L +LR+ G
Sbjct: 404 RLDLAQELRVMKNLDPHPNVVRLLGCC-TEREPMFVILEYVSGGKLQSFLRASREERNHG 462
Query: 320 RHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+T + F + GMEYL + ++HRDLAARN+LI KVADFG
Sbjct: 463 GPGLTSRDLTGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKVADFGFARDVAAN 522
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
+ +LPI+W APE+L N FS KSD+WSFG+L+WEI + G PYP + AEV
Sbjct: 523 QIYERKS--EGRLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEV 580
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+R ++ GYR++ PE C Y +M W DPA RP+F
Sbjct: 581 MRRIKEGYRLDRPEHCKRELYNIMYYCWDKDPACRPSF 618
>UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14482, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 621
Score = 170 bits (413), Expect = 9e-41
Identities = 101/260 (38%), Positives = 140/260 (53%), Gaps = 13/260 (5%)
Query: 226 IDERDLEIREN-IGKGEFGDVMLGI--LNGTQK-VAVKILKDREAASKFRAE----ASVM 277
+D L + + +G G FG VM GI + T+K VAVKILK+ E R E A+VM
Sbjct: 351 VDRSQLFLEDGELGSGNFGTVMKGIYKMKKTEKTVAVKILKNDEDNLSVREEMLREANVM 410
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
L + +VR++G+ + LV E G L +L+ + ++ N
Sbjct: 411 QQLDNPYIVRMIGIC--EAENLMLVMELAELGPLHKFLQKHKQ--ISMKNITELVHQVSV 466
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM+YLE VHRDLAARNVL+ + AK++DFG K P+KW
Sbjct: 467 GMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAVAEDKSYYKAKG-HGKWPVKWY 525
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APE + Y KFS+KSD+WSFG+L+WE +SFG+ PY + EV++ +E G RMEAP CP
Sbjct: 526 APECINYFKFSSKSDVWSFGVLMWEAFSFGQKPYKGMKGNEVMQMIESGQRMEAPANCPS 585
Query: 458 GPYELMRAAWHADPASRPTF 477
+LM+A W RP+F
Sbjct: 586 EMSDLMQACWTYKVEDRPSF 605
Score = 58.8 bits (136), Expect = 3e-07
Identities = 40/101 (39%), Positives = 56/101 (55%), Gaps = 10/101 (9%)
Query: 58 WHHGAISRERAEALL-SGSP-DGVFLVRE-STNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
W HGAI+RE +E L +GS +G FLVR+ TN G + LC+ G+V HYRV
Sbjct: 163 WFHGAITREGSEPRLQNGSRINGRFLVRQRDTN--GSYALCLLHEGQVMHYRVD-----R 215
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLPK 155
+Q +L+I + + FD + L+ HY DGL L P+
Sbjct: 216 DQAGKLSIPEGKKFDTLWQLVEHYSYKPDGLLHVLTEPCPR 256
Score = 50.0 bits (114), Expect = 1e-04
Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 7/100 (7%)
Query: 52 NMTQWPWHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKW 109
N++ P+ +G I+RE AE L +G DG++L+R+S N G L V GR HY ++
Sbjct: 4 NVSALPFFYGNITREEAEDYLQLAGMADGLYLLRQSRNNLGGFALSVSSSGRSYHYSIE- 62
Query: 110 ATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
N+ I + + D+I ++ Q DGL T L
Sbjct: 63 ----RQANETYAIPGGKSHQDPVDVIDYHSQVMDGLVTLL 98
>UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG3969-PA, isoform A - Tribolium castaneum
Length = 1268
Score = 169 bits (412), Expect = 1e-40
Identities = 100/288 (34%), Positives = 156/288 (54%), Gaps = 14/288 (4%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGIL--NGTQ-KVAVKIL-KDREAAS--KFRAE 273
V ++ I + I + +G GEFG V G+ G + +VA+K L +DR ++ +F E
Sbjct: 112 VSSKHIIPAASITINKELGMGEFGVVQQGVWCNEGERIQVAIKCLSRDRMQSNMVEFLKE 171
Query: 274 ASVMASLKHENLVRLLGLVFTS-SGGTCLVTEHCAQGSLLDYLRSRG-RHYVTQLNQINF 331
AS+M ++ H N+VR G+V + G LVTE SLL+ L+ R L +F
Sbjct: 172 ASIMHNIDHPNIVRFFGVVLPNVEGSLMLVTELAPLRSLLECLKEPSLRSSFPVLTLCDF 231
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX-QA 390
A+ C GM+YLE R++HRDLAARN+L+ ++ K++DFG
Sbjct: 232 AYQICDGMQYLEANRLIHRDLAARNILVFSKSKVKISDFGLSRALGQGKDYYQTNFNVNL 291
Query: 391 KLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG--YR 448
KLPI W APE + Y +F+ SD+W+FG+ LWE++S+G P+ + +++ ++ R
Sbjct: 292 KLPIAWCAPECISYLRFTTSSDVWAFGVTLWEMFSYGFQPWAALTGQQILEAIDEPNFQR 351
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
+E P+ CP Y LM W + ++RP F + LA+ R P Q+Q
Sbjct: 352 LEQPDCCPLDHYNLMLDCWRHEASARPKFAEIGPVLAECR---PEQVQ 396
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 169 bits (412), Expect = 1e-40
Identities = 99/288 (34%), Positives = 154/288 (53%), Gaps = 26/288 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVM----LGILNGTQK--VAVKILKDREAASKFR-- 271
+D W++D + + +G+G FG V+ +G+ N + VAVK+L + +
Sbjct: 263 LDEEWELDRSQISLLGILGEGAFGRVVKADAIGLPNMPYRCNVAVKMLXEDATEHELADL 322
Query: 272 -AEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGR--HYVTQLN 327
+E VM ++ +H N++ L+G T G +V E+ +QG+L +LR+R Y L
Sbjct: 323 VSEMEVMKTIGQHVNIINLIGAC-TQKGPLFVVVEYASQGNLRQFLRARRPIPEYANPLT 381
Query: 328 Q-----------INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXX 376
+ ++F++ GMEYLE ++ +HRDLAARNVL+S K+ADFG
Sbjct: 382 EPPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDI 441
Query: 377 XXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 436
+LP+KW A EAL ++ +SD+W++GIL+WEI +FG PYP IPL
Sbjct: 442 HDIDYYRKTT--DGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPL 499
Query: 437 AEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
++ ++ GYRME P C Y LM WH +P RPTF + + +
Sbjct: 500 WKLFELLKEGYRMEQPVNCQDDVYALMLRCWHENPNQRPTFAEIVKEM 547
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila
melanogaster|Rep: Tyrosine-protein kinase transmembrane
receptor Ror precursor - Drosophila melanogaster (Fruit
fly)
Length = 685
Score = 169 bits (412), Expect = 1e-40
Identities = 94/266 (35%), Positives = 137/266 (51%), Gaps = 13/266 (4%)
Query: 229 RDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKDREAASK---FRAEASVMASLK 281
+D+E E +G+G FG V G L K VA+K LK+ + F+ E +++ LK
Sbjct: 408 QDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLK 467
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINF---AFDACCG 338
H+N+V +LG+V C++ E+ A G L ++L S L+Q+ F A G
Sbjct: 468 HQNIVCILGVVLNKEP-YCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEG 526
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M+YL VHRDLAARN L++ K++DFG ++ LP++W
Sbjct: 527 MQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQS--KSLLPVRWMP 584
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
E++ Y KF+ +SD+WSFG++LWEIYS+G PY EV+ + + APE CP
Sbjct: 585 SESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTA 644
Query: 459 PYELMRAAWHADPASRPTFLHMRRNL 484
Y LM WH RPTF + L
Sbjct: 645 VYSLMIECWHEQSVKRPTFTDISNRL 670
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 169 bits (412), Expect = 1e-40
Identities = 92/250 (36%), Positives = 137/250 (54%), Gaps = 13/250 (5%)
Query: 237 IGKGEFGDVMLGIL---NGTQKV--AVKILK---DREAASKFRAEASVMASLKHENLVRL 288
IG GEFG+V G+L +G ++V A+K LK + F EA +M H N++RL
Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 678
Query: 289 LGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDACCGMEYLERQRV 347
G++ + ++TE+ G+L +LR + G V QL + GM+YL
Sbjct: 679 EGVI-SKYKPMMIITEYMENGALDKFLREKDGEFSVLQL--VGMLRGIAAGMKYLANMNY 735
Query: 348 VHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKF 407
VHRDLAARN+L+++ KV+DFG K+PI+WTAPEA+ Y KF
Sbjct: 736 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG-GKIPIRWTAPEAISYRKF 794
Query: 408 SNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAW 467
++ SD+WSFGI++WE+ ++G PY + EV++ + G+R+ P CP Y+LM W
Sbjct: 795 TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCW 854
Query: 468 HADPASRPTF 477
+ A RP F
Sbjct: 855 QQERARRPKF 864
>UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13;
Euteleostomi|Rep: Activated CDC42 kinase 2 - Bos taurus
(Bovine)
Length = 747
Score = 169 bits (412), Expect = 1e-40
Identities = 108/308 (35%), Positives = 156/308 (50%), Gaps = 19/308 (6%)
Query: 202 APAASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNG----TQKVA 257
+P +G+LQS + + I E+DL + E +G G FG V G + T VA
Sbjct: 102 SPTPGGSAGEGSLQSLTCL-----IGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVA 156
Query: 258 VKILK-----DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
VK LK EA F E + M SL H NL+RL G+V T +VTE GSLL
Sbjct: 157 VKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP--MKMVTELAPLGSLL 214
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
D LR H++ +A GM YLE +R +HRDLAARN+L++ K+ DFG
Sbjct: 215 DRLRKHQGHFLLGTLS-RYAVQVAEGMGYLEAKRFIHRDLAARNLLLATRDLVKIGDFGL 273
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYP 432
+ K+P W APE+LK FS+ SD W FG+ LWE++++G+ P+
Sbjct: 274 MRALPQNDDHYVMQEHR-KVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWI 332
Query: 433 RIPLAEVVRHVER-GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
+ ++++ +++ G R+ PE CP Y +M W P RPTF+ +R L + +
Sbjct: 333 GLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 392
Query: 492 PAQLQLWE 499
LQ +E
Sbjct: 393 MRALQDFE 400
>UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle
specific tyrosine kinase receptor; n=1;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
muscle specific tyrosine kinase receptor -
Strongylocentrotus purpuratus
Length = 827
Score = 169 bits (411), Expect = 2e-40
Identities = 96/274 (35%), Positives = 146/274 (53%), Gaps = 24/274 (8%)
Query: 235 ENIGKGEFGDVMLG----ILNGTQK--VAVKILK---DREAASKFRAEASVMASLKHENL 285
++IG+G FG V + ++ G + VAVK+LK D+ F EA ++A H+N+
Sbjct: 543 KDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNI 602
Query: 286 VRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY------------VTQLNQINFAF 333
V+LLG+ F CL+ E+ ++G L DYL SR H + ++N A
Sbjct: 603 VKLLGVCFVGRP-LCLLLEYMSEGDLEDYLHSRSPHRSNSRTSNSPGSGLKTYEKLNMAK 661
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
CGM YL VHRD+A RN LI++ K++DFG + +P
Sbjct: 662 QIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECFVGHK--EEHIP 719
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
I+WTAPEAL +F+ SD+WSFG+LLWE++S+ PY + +V H +GYR+ + E
Sbjct: 720 IRWTAPEALWDYQFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLE 779
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
P +++M W A+PA RP F ++ +LA +
Sbjct: 780 NTPQKVHQIMGECWQANPADRPFFKQLQDSLASM 813
>UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=2; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 1071
Score = 169 bits (411), Expect = 2e-40
Identities = 93/261 (35%), Positives = 138/261 (52%), Gaps = 10/261 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
+ID ++I + IG GEFG+V G L K VA+K LK F +EAS+M
Sbjct: 718 EIDISCVKIEQVIGAGEFGEVCSGNLRQPGKREILVAIKTLKVGYTERQRRDFLSEASIM 777
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H N++ L G+V T S ++TE GSL +LR + T + +
Sbjct: 778 GQFDHPNIIHLEGVV-TKSSPVMIITEFMENGSLDSFLRQNDGQF-TVIQLVGMLRGIAA 835
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPIKW 396
G++YL VHRDLAARN+L+++ KV+DFG K+PI+W
Sbjct: 836 GVKYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 895
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
TAPEA++Y KF++ SD WS+GI++WE+ S+G PY + +V+ +E+ YR+ P CP
Sbjct: 896 TAPEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCP 955
Query: 457 PGPYELMRAAWHADPASRPTF 477
++LM W + +RP F
Sbjct: 956 SALHQLMLDCWQKERNNRPKF 976
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 169 bits (411), Expect = 2e-40
Identities = 99/262 (37%), Positives = 140/262 (53%), Gaps = 12/262 (4%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVM 277
+ID ++I E IG GEFG+V G L + VA+K LK F AEAS+M
Sbjct: 630 EIDISCVKIEEVIGAGEFGEVCRGRLKQAGRREMVVAIKTLKAGYTERQRRDFLAEASIM 689
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGRHYVTQLNQINFAFDAC 336
H N++RL G V T S ++TE G+L +LR + GR +TQL +
Sbjct: 690 GQFDHPNVIRLEG-VLTRSCPVLIITEFMENGALDSFLRLNDGRFTMTQL--VGMLRGVA 746
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPIK 395
GM+YL VHRDLAARN+L+++ KV+DFG K+PI+
Sbjct: 747 AGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLDDTSADPTYTSSLGGKIPIR 806
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
WTAPEA+ + KF+ SD+WS+GI++WE+ S+G PY + +V+ VE+ YR+ P C
Sbjct: 807 WTAPEAIAFRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQDYRLPPPMDC 866
Query: 456 PPGPYELMRAAWHADPASRPTF 477
P ++LM W + RP F
Sbjct: 867 PMVLHQLMLECWMKERNLRPKF 888
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 169 bits (411), Expect = 2e-40
Identities = 98/281 (34%), Positives = 150/281 (53%), Gaps = 24/281 (8%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGILN------GTQKVAVKILKDREAASKFRA-- 272
D++W+ +L + +G+GEFG V+ G G VAVK+LK + + A
Sbjct: 477 DSKWEFPRTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTGANSVELLALL 536
Query: 273 -EASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR-----GRHY--- 322
E ++ + H N++RLLG T L+ E+C GSL +YLR SR Y
Sbjct: 537 SEYQLLQEVNHPNVIRLLGAC-TKGDSPLLIIEYCQYGSLKNYLRLSRKLEVLNADYENA 595
Query: 323 ---VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+T + ++FA+ GM YL ++VHRDLAARNVL++ K++DFG
Sbjct: 596 VEPITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYED 655
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
+ ++P+KW APE+L + ++ KSD+W+FG+L WE+ + G PYP IP +
Sbjct: 656 DAYLKKS--KDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNL 713
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHM 480
+++GYRME P+ C Y ++R W DP RP+F H+
Sbjct: 714 YNLLKQGYRMECPKNCSEEIYGIVRLCWADDPKQRPSFKHL 754
>UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2;
Anthomedusae|Rep: Protein-tyrosine kinase - Hydractinia
echinata (Snail fur) (Hermit crab hydroid)
Length = 1162
Score = 169 bits (411), Expect = 2e-40
Identities = 94/278 (33%), Positives = 144/278 (51%), Gaps = 18/278 (6%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQK-----VAVKILK---DREA-----ASKF 270
+++ DL + E IG+G+FGDV G VAVK K D+E A KF
Sbjct: 422 YEVARDDLTLDEIIGQGQFGDVYQGTFKSKISSVEIPVAVKTYKIELDKEQEDGTRAEKF 481
Query: 271 RAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQIN 330
EA +M H ++++L+G+V S + ++ E + G L YL+ R +
Sbjct: 482 LEEAYLMQQFDHPHVIKLIGIV--SDSPSYIIMELASYGELRSYLQQY-RTQTESERLLT 538
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQA 390
+ + + YLE + VHRD+AARN+L + T K+ADFG +
Sbjct: 539 YIYQLSTALSYLESRNFVHRDIAARNILAADPHTIKLADFGLSRWIDEEQSYYKAS--KG 596
Query: 391 KLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRME 450
KLPIKW APE++ + +FS+ SD+W FG+ WEI +G P+ +P +V+ +E G R+
Sbjct: 597 KLPIKWMAPESINFRRFSSASDVWMFGVCCWEILMYGVKPFQGVPNEKVIGKIENGERLP 656
Query: 451 APEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
P C P Y LM +WH +P+ RPTF ++ L+ I+
Sbjct: 657 LPPNCAPTLYHLMTESWHYEPSKRPTFQELKSRLSQIK 694
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 168 bits (409), Expect = 3e-40
Identities = 105/301 (34%), Positives = 157/301 (52%), Gaps = 30/301 (9%)
Query: 211 DGTLQSQSF-VDARWKIDERDLEIRENIGKGEFGDVM----LGILN--GTQKVAVKILKD 263
DG + +D+ W+I L + +++G+G FG V+ +G+L + VAVK+LK+
Sbjct: 512 DGMISEYELPMDSDWEIPRSMLCLGKSLGEGAFGKVVKAEAVGLLKPGASSIVAVKMLKE 571
Query: 264 REAASKFRAEASVMASLK----HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS-- 317
++ S M +K H N++ LLG T G +V E+ G+L D+LR
Sbjct: 572 GHTDNEMMDLVSEMEMMKMIGKHNNIINLLGCC-TQGGPLYVVVEYAPYGNLRDFLRQHR 630
Query: 318 -------------RGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGT 364
+ + +TQ + ++FA+ GMEYL +R +HRDLAARNVL+S +
Sbjct: 631 PSSGYEPAIGLEEKEKKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYF 690
Query: 365 AKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIY 424
K+ADFG +LP+KW APEAL + ++ +SD+WS+GILLWEI
Sbjct: 691 LKIADFGLARDIHCNDYYRKTT--DGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIM 748
Query: 425 SFGRVPYPRIPLAE-VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRN 483
+ G PYP +P E + + + G+RME P C Y LMR W P RPTF + +
Sbjct: 749 TLGGTPYPSVPSVEKLFQLLRNGHRMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVED 808
Query: 484 L 484
L
Sbjct: 809 L 809
>UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2;
Caenorhabditis elegans|Rep: Isoform b of Q10925 -
Caenorhabditis elegans
Length = 1130
Score = 168 bits (409), Expect = 3e-40
Identities = 96/283 (33%), Positives = 153/283 (54%), Gaps = 11/283 (3%)
Query: 209 QTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILKD- 263
Q D ++ +Q+ +D + I +++ E IG+G F V G NGT VAVKIL+D
Sbjct: 85 QADQSMPAQNSIDEKALIPNEQIKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDI 144
Query: 264 -REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY 322
R EAS + L+H +L+RL G+V + +V E C GSLLD LR +
Sbjct: 145 SPNIMDDLRVEASHLLKLQHPSLIRLYGIVRQPA---MMVFELCEGGSLLDRLRDDKKAI 201
Query: 323 VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISA-EGTAKVADFGXXXXXXXXXX 381
+ ++ +++LE + VHRD+AARN+L++ E T K+ DFG
Sbjct: 202 LLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQ 261
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
Q K+P W PEAL++ KFS+ SD+WS+G+ +WE+++FG P+ +V++
Sbjct: 262 MYTMAP-QKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLK 320
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+++ G R+E P+ C Y++M+ W +PA R F +R +L
Sbjct: 321 NIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL 363
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 168 bits (409), Expect = 3e-40
Identities = 102/291 (35%), Positives = 152/291 (52%), Gaps = 29/291 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILKDREAASKFR-- 271
+D W+ L + +++G+G FG V++ NG K VAVK+LK+ + +
Sbjct: 615 IDLNWEFPRSKLVLGKSLGEGAFGKVVMAEANGLVKGQASTVVAVKMLKEGHTDADVKDL 674
Query: 272 -AEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS------------ 317
E VM + KH N++ LLG G ++ E+ G+L D+LRS
Sbjct: 675 VCEMEVMKMIGKHVNIINLLGCC-CKDGPLYVIVEYAPHGNLKDFLRSHRFGTANYEDMI 733
Query: 318 ---RGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
+ + +TQ I+FA+ GME+L +R +HRDLAARNVL+S K+ADFG
Sbjct: 734 SGEKEKKILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR 793
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
KLPI+W APE+L+ + ++SD+WSFG+LLWEI + G PY I
Sbjct: 794 DIHSQEYYRKTTT--GKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYSSI 851
Query: 435 PLAE-VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
P + ++ H+++G R+E P C Y MR WH P RPTF + ++L
Sbjct: 852 PTWDNLLEHLKKGKRLEQPPLCSIDIYLFMRECWHYRPEERPTFSEIVQHL 902
>UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25;
n=2; Caenorhabditis|Rep: Probable tyrosine-protein
kinase kin-25 - Caenorhabditis elegans
Length = 1237
Score = 168 bits (409), Expect = 3e-40
Identities = 96/283 (33%), Positives = 153/283 (54%), Gaps = 11/283 (3%)
Query: 209 QTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILKD- 263
Q D ++ +Q+ +D + I +++ E IG+G F V G NGT VAVKIL+D
Sbjct: 85 QADQSMPAQNSIDEKALIPNEQIKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDI 144
Query: 264 -REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY 322
R EAS + L+H +L+RL G+V + +V E C GSLLD LR +
Sbjct: 145 SPNIMDDLRVEASHLLKLQHPSLIRLYGIVRQPA---MMVFELCEGGSLLDRLRDDKKAI 201
Query: 323 VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISA-EGTAKVADFGXXXXXXXXXX 381
+ ++ +++LE + VHRD+AARN+L++ E T K+ DFG
Sbjct: 202 LLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQ 261
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
Q K+P W PEAL++ KFS+ SD+WS+G+ +WE+++FG P+ +V++
Sbjct: 262 MYTMAP-QKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLK 320
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+++ G R+E P+ C Y++M+ W +PA R F +R +L
Sbjct: 321 NIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL 363
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 168 bits (408), Expect = 4e-40
Identities = 100/270 (37%), Positives = 143/270 (52%), Gaps = 17/270 (6%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKD---REAASKFRAEASVM 277
+ID ++I + IG GEFG+V G L K VA+K LK + F +EAS+M
Sbjct: 636 EIDISCVKIEQVIGAGEFGEVCSGNLKLPGKREMFVAIKTLKTGYTEKQRRDFLSEASIM 695
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS--RGRHYVTQLNQINFAFDA 335
H N++ L G+V T S ++TE GSL +LR G V L I
Sbjct: 696 GQFDHPNVIHLEGVV-TKSSPVMIITEFMENGSLDAFLRVSIHGDQLVGMLRGI------ 748
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXX-XXXXXXQAKLPI 394
GM+YL VHRDLAARN+L+++ KV+DFG K+PI
Sbjct: 749 ASGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPI 808
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG 454
+WTAPEA++Y KF++ SD+WS+GI++WE+ S+G PY + +V+ +E+ YR+ P
Sbjct: 809 RWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMD 868
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNL 484
CP ++LM W D +RP F + NL
Sbjct: 869 CPSTLHQLMLDCWQKDRNNRPKFSQIVNNL 898
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 168 bits (408), Expect = 4e-40
Identities = 97/257 (37%), Positives = 141/257 (54%), Gaps = 11/257 (4%)
Query: 228 ERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKIL-KDR--EAASKFRAEASVMASL 280
+ + + +G GEFG V+ GI G + VA+K L KD+ + +F EA VM+ L
Sbjct: 481 KESISFGKELGVGEFGSVIKGIWLSPGGKEINVAMKTLHKDKMVQGEKEFLREALVMSQL 540
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGME 340
H +V LLG+ LV E G+LLDYL + + +++ +A GM
Sbjct: 541 NHPCIVSLLGVCLGPP--MILVQELVEMGALLDYLMDY-QPEIQEVDLKLWASQIAFGMM 597
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE +R VHRDLAARN+L++ + K++DFG + P++W APE
Sbjct: 598 YLELKRFVHRDLAARNILLANKKQVKISDFGLSRAVGTGSDYYQAKQG-GRWPVRWYAPE 656
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
++ Y FS KSD+WS+GI LWE+++FG +PY + EVV +E R+E P+ CP Y
Sbjct: 657 SINYGTFSTKSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFLEHCGRLEKPDECPIHTY 716
Query: 461 ELMRAAWHADPASRPTF 477
+M + WH DP RPTF
Sbjct: 717 SIMLSCWHIDPNKRPTF 733
Score = 60.5 bits (140), Expect = 1e-07
Identities = 35/95 (36%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
W+HG I+RE A +L G DG FL+R+ N P D+ L + FR ++ H+++ DN
Sbjct: 10 WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRSQILHFQIN--CLGDN 67
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLV 150
+ +ID+ F + LI +Y +DGL KLV
Sbjct: 68 ---KFSIDNGPIFQGLDMLISYYKVISDGLPCKLV 99
Score = 49.6 bits (113), Expect = 2e-04
Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 9/107 (8%)
Query: 45 PAGNRLVNMTQWPWHHGAISRERAEALLSGSP--DGVFLVRESTNFPGDHTLCVRFRGRV 102
P ++TQW H + R A +L + DG FL+R S G + L + + +
Sbjct: 276 PVNQPKTSITQWL--HQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKT 333
Query: 103 EHYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
H+++K ++ IDD F+ + L+ HY+Q ADGL T L
Sbjct: 334 YHFQIK-----SRADRWFYIDDGPLFETLPHLVDHYMQYADGLPTLL 375
>UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12;
Tetrapoda|Rep: Arg protein-tyrosine kinase - Xenopus
laevis (African clawed frog)
Length = 721
Score = 167 bits (407), Expect = 5e-40
Identities = 77/139 (55%), Positives = 93/139 (66%), Gaps = 3/139 (2%)
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
MEYLER+ +HRDLAARN L+ KVADFG AK PIKWTA
Sbjct: 5 MEYLERKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAG---AKFPIKWTA 61
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PE+L YN FS KSD+W+FG+LLWEI ++G PYP I L++V +E+GYRME PEGCPP
Sbjct: 62 PESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPK 121
Query: 459 PYELMRAAWHADPASRPTF 477
YELMRA W +P+ RP+F
Sbjct: 122 VYELMRACWQWNPSDRPSF 140
>UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep:
Tyrosine kinase - Schistosoma mansoni (Blood fluke)
Length = 1264
Score = 167 bits (405), Expect = 8e-40
Identities = 96/276 (34%), Positives = 146/276 (52%), Gaps = 13/276 (4%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILKDREAAS----KFRAEASVM 277
++ + + ++E +G G FG V+ G+ +G + VAVK LK + A+ + AEA M
Sbjct: 883 LNSQTVTLKERLGGGNFGHVVKGLYRTPSGQEVPVAVKTLKPNQIANSGEREILAEARTM 942
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
A LKH ++VRL+G+ LV E G + YL+ R V L ++
Sbjct: 943 AQLKHRHIVRLIGVCKEEQ--FMLVLELAPLGPINKYLKKRPDVSVHTLTEL--MHQVAL 998
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YLE + VHRDLAARNVL+ AK++DFG K P+KW
Sbjct: 999 GMAYLESCKFVHRDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAATA-GKWPLKWY 1057
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APE + Y +F +KSD+WS+GI LWE+YS+G PY + A+++ +++G R+ P CP
Sbjct: 1058 APECIYYFRFDSKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPE 1117
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPA 493
Y +M+ W+ + RPTF + ++ I P+
Sbjct: 1118 SIYSIMQQCWNFEGVHRPTFAELVLTISRILRAMPS 1153
Score = 51.2 bits (117), Expect = 6e-05
Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 9/100 (9%)
Query: 57 PWHHGAISRERAEALLS--GSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW+H I R AE+ L+ G+ DG FLVR + L + + +HYR+ +
Sbjct: 201 PWYHHTIRRYEAESRLASEGNQDGAFLVRYRKE-DRTYVLSLTSQNEPKHYRI------E 253
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKLVRCLP 154
R +I+ ++F+ + +LI HY DGL KL + +P
Sbjct: 254 EYLSRWSIEGGQYFETIMELIDHYHFRQDGLLCKLQKPIP 293
Score = 44.0 bits (99), Expect = 0.010
Identities = 30/92 (32%), Positives = 48/92 (52%), Gaps = 9/92 (9%)
Query: 58 WHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPDN 115
+ +G I+RE+AE LL +G+ +G+FL+RES N ++ + + GRV HY V+ T
Sbjct: 49 YFYGKITREQAEELLFTNGANEGLFLLRESVN--RNYAVSICHLGRVHHYNVERHT---- 102
Query: 116 QNQRLTIDDEEFFDNMTDLIHHYLQDADGLCT 147
+ I F +L+ H+ DG T
Sbjct: 103 -DCSYRIQTGHKFIGPVELVQHHSTQLDGFLT 133
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 166 bits (404), Expect = 1e-39
Identities = 102/291 (35%), Positives = 149/291 (51%), Gaps = 20/291 (6%)
Query: 211 DGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILKD- 263
DG L V++ ++ L++ +GKG FG+V + + VAVK L++
Sbjct: 1173 DGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLRED 1232
Query: 264 --REAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGR- 320
RE F EA++MA H N+V L+G+ F +V E A G L +LR
Sbjct: 1233 PKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQP-YYIVLELLAGGDLQKFLRENRNT 1291
Query: 321 ----HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXX 373
+T + + A D G Y+E +R +HRD+AARN L+S++G K+ADFG
Sbjct: 1292 PERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMS 1351
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
+A LPIKW PEA F++K+D+WSFGILLWE++S GR PYP
Sbjct: 1352 RDIYRSDYYRKGG--KAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPG 1409
Query: 434 IPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+V+ V RG R+ +P CP Y++M W+ P RPTF+ + +L
Sbjct: 1410 QHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL 1460
>UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome
shotgun sequence; n=3; Fungi/Metazoa group|Rep:
Chromosome 3 SCAF14978, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 958
Score = 166 bits (403), Expect = 1e-39
Identities = 91/272 (33%), Positives = 151/272 (55%), Gaps = 14/272 (5%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-----KVAVKILKDREA--ASKFRAEAS 275
++KI D+ + + +G+G FG+V G+ TQ VA+K K+ A KF +EAS
Sbjct: 379 KYKISRDDIIVGQILGEGFFGEVHNGVYK-TQTGENLSVAIKTCKNCSADVKEKFLSEAS 437
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
VM +L H ++VRL+G++ + +V E G L YL + ++ +T + I +
Sbjct: 438 VMKNLDHPHIVRLIGVI--EADPVWIVMELYEHGELGKYLVEQ-QYSLTTVMLITYCLQI 494
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
C + YLE VVHRD+A RN+L+++ K+ DFG ++LPIK
Sbjct: 495 CKALAYLEGLNVVHRDIAVRNILVASPLCVKLGDFGLSRYIEEEEYYKASA---SRLPIK 551
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
W APE++ + +F+ SD+W FG+ +WEI+S + P+ + ++V+ +E G R+ P+ C
Sbjct: 552 WMAPESINFRRFTTASDVWMFGVCVWEIFSMAQQPFFWLENSQVIDQLESGIRLPKPQLC 611
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
PP Y L+ + W +P RP F H+ +L++I
Sbjct: 612 PPTVYSLVSSCWSHEPHLRPQFSHLACSLSEI 643
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 166 bits (403), Expect = 1e-39
Identities = 96/268 (35%), Positives = 146/268 (54%), Gaps = 15/268 (5%)
Query: 229 RDLEIREN--IGKGEFGDVMLGIL-----NGTQKVAVK-ILKDR--EAASKFRAEASVMA 278
+D E+R+ +G G FG V G+ N VA+K +LK E++ +F EA +MA
Sbjct: 934 KDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMA 993
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
S +H NL++LL + +S L+T+ G LLDY+R+ R + +N++ G
Sbjct: 994 SEEHVNLLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRNN-RDKIGSKALLNWSTQIAKG 1050
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YLE +R+VHRDLAARNVL+ K+ DFG K+PIKW A
Sbjct: 1051 MSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG--GKMPIKWLA 1108
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
E ++ F++KSD+W+FG+ +WE+ +FG+ P+ IP ++ +E G ++E PE C
Sbjct: 1109 LECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLD 1168
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLAD 486
Y + + WH D A RPTF + A+
Sbjct: 1169 IYCTLLSCWHLDAAMRPTFKQLTTVFAE 1196
>UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10323,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 815
Score = 165 bits (402), Expect = 2e-39
Identities = 91/250 (36%), Positives = 129/250 (51%), Gaps = 10/250 (4%)
Query: 231 LEIRENIGKGEFGDVMLGILNGTQK----VAVKILK---DREAASKFRAEASVMASLKHE 283
+ I IG GEFG+V G L K VA+K LK + F EAS+M H
Sbjct: 478 ISIERIIGAGEFGEVCSGPLRLPGKREILVAIKTLKAGYTEQQRRDFLWEASIMGQFNHP 537
Query: 284 NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLE 343
N++RL G+V T S ++TE+ GSL +L+ + T + + GM YL
Sbjct: 538 NIIRLEGVV-TKSKPVMIITEYMENGSLDTFLKKNDGQF-TVIQLVGMLRGIASGMRYLS 595
Query: 344 RQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALK 403
VHRDLAARN+L+ KV+DFG K+PI+WTAPEA+
Sbjct: 596 DMGYVHRDLAARNILVDGHLVCKVSDFGLSRALEDDPEAAYTTQG-GKIPIRWTAPEAIA 654
Query: 404 YNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELM 463
Y KF++ SD+WS+G+++WE+ S+G PY + +V++ VE YR+ P CP Y+LM
Sbjct: 655 YRKFTSASDVWSYGVVMWEVMSYGERPYWDMSNQDVIKAVEENYRLPGPMDCPESLYQLM 714
Query: 464 RAAWHADPAS 473
W + S
Sbjct: 715 TDCWQRERTS 724
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 165 bits (402), Expect = 2e-39
Identities = 103/281 (36%), Positives = 147/281 (52%), Gaps = 24/281 (8%)
Query: 218 SFVDARWKIDERDLEIRENIGKGEFGDVM------LGILNGTQKVAVKILKDREAASK-- 269
S V RW+ L++ +G+G FG V + G AVK LK+ + ++
Sbjct: 371 SIVKDRWEFPRHRLKVFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEAERN 430
Query: 270 -FRAEASVMASLK-HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG--RHY--- 322
+E V+ SL+ H N+VRLLG T ++ E+ G L +LR+ +HY
Sbjct: 431 DLLSELQVLKSLEPHINVVRLLGCC-TEKDPIFVILEYVNMGKLQTFLRNSRVEKHYGNT 489
Query: 323 ------VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXX 376
+T + +F + GM++L + ++HRDLAARN+LI+ + T KVADFG
Sbjct: 490 HGKSKILTSGDLTSFMYQVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARDI 549
Query: 377 XXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 436
+ +LPI+W A E+L N F+ KSD+WSFGIL+WEI + G PYP I
Sbjct: 550 VTSKVYERKS--EGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAA 607
Query: 437 AEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
A+V+R V GYR+E PE C Y +M W ADP RP F
Sbjct: 608 ADVMRKVRDGYRLEKPEHCRRELYNIMFYCWAADPNERPGF 648
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 165 bits (402), Expect = 2e-39
Identities = 104/282 (36%), Positives = 151/282 (53%), Gaps = 29/282 (10%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK----DREAASKFRAEAS 275
+D+ W++ L + +G+G FG V++ +N VAVK++K D + AS R E
Sbjct: 405 LDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVR-EME 462
Query: 276 VMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYL---RSRGR----------- 320
VM + +H N++ LLG + +G ++ E+ G+L D+L R GR
Sbjct: 463 VMKIIGRHINIINLLGCC-SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPP 521
Query: 321 ----HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXX 376
H +T+ + I FA GM+YL +R +HRDLAARNVL+S + K+ADFG
Sbjct: 522 SPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI 581
Query: 377 XXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 436
+LPIKW APE+L+ + +KSD+WS+GILLWEI ++G+ PYP I
Sbjct: 582 QSTDYYRKNT--NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS 639
Query: 437 A-EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
A E+ ++ G RME P C Y LMR WH + RP F
Sbjct: 640 AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPF 681
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 165 bits (401), Expect = 2e-39
Identities = 105/288 (36%), Positives = 145/288 (50%), Gaps = 20/288 (6%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGT-------QKVAVKILKDREAAS 268
S +V W+ LEI +GKG FG V G+ G +VA+K ++ +
Sbjct: 684 SDMYVADEWEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEISRVAIKSVQANASMR 743
Query: 269 ---KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY--- 322
+F EASVM + N+VRLLG+V + T ++ E AQG L ++LR+R
Sbjct: 744 DRIEFLNEASVMKLIDAHNVVRLLGVV-SKGQPTYVIMEFMAQGDLKNWLRARRPENQQD 802
Query: 323 ---VTQLNQI-NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXX 378
V L Q+ N A + GM +L ++ VHRDL+ARN L+S EGT KVADFG
Sbjct: 803 LPSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQ 862
Query: 379 XXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAE 438
LPI+W APE++K F SD+WSFGILLWE+ + G +PY + E
Sbjct: 863 SDYYRKERGGM--LPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEE 920
Query: 439 VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLAD 486
+++ G + PE CP E+M A W RP F + NL D
Sbjct: 921 AGEYIKGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQD 968
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 165 bits (400), Expect = 3e-39
Identities = 102/283 (36%), Positives = 147/283 (51%), Gaps = 20/283 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDV-------MLGILNGTQKVAVKILKDR---EAASKFRAEA 274
K +L++ I +GEFG+V +LG G VAVK L+ E KF AEA
Sbjct: 1696 KFPRGNLKLENFIDRGEFGEVFQGTATDILGPGTGPIPVAVKTLRKGAIIEEQKKFLAEA 1755
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS----RGRHYVTQLNQIN 330
++M + H N+V++LG V + ++ E G LL +LR RG +T I
Sbjct: 1756 ALMGNFNHPNIVKVLG-VCVENDPVYIIMELMPGGDLLHFLRDAKVERGPPLLTVKELIQ 1814
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEGT---AKVADFGXXXXXXXXXXXXXXXX 387
A D G YL++ +HRDLAARN L+S++G K+ DFG
Sbjct: 1815 IALDVAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDFGLAKDLYSSDYYQVEG- 1873
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
Q KLP++W APEAL KF+ +SD+WSFG+L+WEI +FG PYP + EV++ V
Sbjct: 1874 -QRKLPVRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYPALNNQEVLQFVTAEG 1932
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
R++ PE CP Y+LM+ W + R F ++ L + +H
Sbjct: 1933 RLQKPENCPGKIYQLMQNCWKKVASERLHFDVIKEILNNYLEH 1975
>UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;
Aplysia californica|Rep: Trk-like receptor tyrosine
kinase - Aplysia californica (California sea hare)
Length = 865
Score = 165 bits (400), Expect = 3e-39
Identities = 101/300 (33%), Positives = 152/300 (50%), Gaps = 27/300 (9%)
Query: 231 LEIRENIGKGEFGDVMLGILNGTQ-----KVAVKILKDR---EAASKFRAEASVMASLKH 282
L + E +G+G FG V G L + +VAVK+LKD +A F E +M++ H
Sbjct: 295 LTLIEVVGEGAFGQVFRGELRSAEGGACHQVAVKVLKDGASPDAHEDFEREVEIMSAFDH 354
Query: 283 ENLVRLLGLVFTS-SGGTCLVTEHCAQGSLLDYLRSRGRHYVT------QLNQ---INFA 332
+N+++LLG+V G +V E+ G L + LR H + +LN+ + +
Sbjct: 355 DNILKLLGIVVQGVEGAPYMVFEYMEHGDLSELLRRNDPHLRSADSKTFRLNKSDLVEIS 414
Query: 333 FDACCGMEYLERQRVVHRDLAARNVLIS-----AEGTAKVADFGXXXXXXXXXXXXXXXX 387
GM YL QR VHRDLA RN L+ A K++DFG
Sbjct: 415 VQIATGMRYLAAQRFVHRDLATRNCLVGTAPPGAGLLVKISDFGMSRDIYTNDYYKIGGS 474
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
LPI+W +PEA+KY +F+ +SD+W++G++LWEI+S+GR PY EV+ +++G
Sbjct: 475 RM--LPIRWMSPEAIKYGRFTCESDVWAYGVVLWEIFSYGRQPYFGHSNEEVIHFLDQGI 532
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD--HTPAQLQLWELSLVVS 505
++ PE CP Y +M W DP R F + + L D RD + P Q +S V+
Sbjct: 533 LLQRPEDCPSTVYHVMLGCWKGDPRQRIVFDRLLKYLTDYRDRLNKPTHCQQMPMSRPVA 592
>UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC
2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein
2).; n=3; Deuterostomia|Rep: Activated CDC42 kinase 1
(EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor
protein 2). - Takifugu rubripes
Length = 1127
Score = 164 bits (399), Expect = 4e-39
Identities = 99/272 (36%), Positives = 145/272 (53%), Gaps = 14/272 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGI-LNGTQKV---AVKILK-----DREAASKFRAEASV 276
I E+DL + E +G G FG V G L T KV AVK LK +A F E +
Sbjct: 133 IPEKDLTLFEKLGDGSFGVVKRGEWLTPTGKVLNVAVKCLKTDVLSQPDALEDFICEVNA 192
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI-NFAFDA 335
M SL H+NL+RL G+V T +VTE GSLL+ LR ++ + +A
Sbjct: 193 MHSLDHQNLIRLYGVVLTHP--MKMVTELAPLGSLLERLRCVHPQGPVLIHTLCQYAVQV 250
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
CGM YLE++R +HRDLAARN+L+++ K+ DFG + K+P
Sbjct: 251 SCGMAYLEQRRFIHRDLAARNILLASAHKIKIGDFGLMRALPNNHEHYVMQEHR-KVPFA 309
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEG 454
W APE+LK FS+ +D W FG+ LWE+++ G+ P+ + ++++ +++ G R+ PE
Sbjct: 310 WCAPESLKTRTFSHATDTWMFGVTLWEMFTHGQEPWLGLNGSQILHKIDKEGERLPKPED 369
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLAD 486
CP Y +M W P RPTF+ +R L +
Sbjct: 370 CPQDIYNVMLQCWAQKPDDRPTFVALREFLLE 401
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 164 bits (399), Expect = 4e-39
Identities = 105/283 (37%), Positives = 148/283 (52%), Gaps = 20/283 (7%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLG----ILNGTQK--VAVKILKDREAASK---FRAEA 274
++I E ++E+ + IG G FG V G ++ G K VAVK L E+ SK F EA
Sbjct: 92 YEIPEENVELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFLKEA 151
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS-------RGRHYVTQLN 327
SVM + ++VRLLG+V + S ++ E A+G L YLRS R +
Sbjct: 152 SVMKAFNSHHVVRLLGVV-SMSKRPMVIMEFMAKGDLKTYLRSTRPDAEIRKGDPPSLQQ 210
Query: 328 QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXX 387
++ + GM YL + VHRDLAARN L+ + T K+ DFG
Sbjct: 211 KLQMCGEIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDVYETDYYRIDS- 269
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
+ LP++W APE+LK F ++SD+WSFGI+LWEI + PY +V R V G
Sbjct: 270 -RGILPVRWMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHDQVTRFVIDGG 328
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLA-DIRD 489
ME P+ CP Y++M WH P+ RPTFL + +L+ D+ D
Sbjct: 329 YMEQPKECPSKLYDMMLMCWHYSPSMRPTFLEIVASLSPDLSD 371
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 164 bits (398), Expect = 6e-39
Identities = 87/271 (32%), Positives = 141/271 (52%), Gaps = 12/271 (4%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQ----KVAVKILK---DREAASKFRAEASV 276
+++ +++ E +G+G+FGDV G VAVK K D KF EA +
Sbjct: 421 YELQRDQIQLGEILGEGQFGDVHKGTYKAKDGSLIPVAVKTCKREADLNTTEKFLEEAYI 480
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M H+++++L+G+ S +V E G L YL++ + + + +AF
Sbjct: 481 MQKFDHQHIIKLIGVC--SESPVWIVMELAKLGELRAYLQNN-KDDLDLATLLLYAFQLS 537
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
+ YLE ++ VHRD+AARNVL+S+ + K+ DFG + KLPIKW
Sbjct: 538 TALSYLESKKFVHRDIAARNVLVSSHTSVKLGDFGLSRSMNDDQSYYKAS--KGKLPIKW 595
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
+PE++ + +F+ SD+W FG+ +WEI +G P+ + EV+ +E G R+ P CP
Sbjct: 596 MSPESINFRRFTIASDVWMFGVCMWEILMYGIKPFQGVKNNEVLTKIENGERLALPPNCP 655
Query: 457 PGPYELMRAAWHADPASRPTFLHMRRNLADI 487
P Y LM W +P+ RP+F ++ L +I
Sbjct: 656 PRLYSLMSQCWSYEPSKRPSFKEIKEILNEI 686
>UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1;
Eptatretus burgeri|Rep: TEC family protein tyrosine
kinase - Eptatretus burgeri (Inshore hagfish)
Length = 636
Score = 164 bits (398), Expect = 6e-39
Identities = 91/267 (34%), Positives = 139/267 (52%), Gaps = 8/267 (2%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-FRAEASVMASLK 281
+W++D +L +G+G G V LG+ G + +A+++L + A F E +M L
Sbjct: 370 KWELDALELTSLRELGRGALGVVQLGMWRGVRHIAIRMLHEGVLAEDDFFHEVKLMMQLS 429
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDACCGME 340
H NLV+L G+V T +V E+ A G L +L++R G+ L + D C M
Sbjct: 430 HPNLVQLYGVV-TRYRPLRIVMEYLALGCLRTFLQARPGKLGSAWL--LEACSDVCKAMV 486
Query: 341 YLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPE 400
YLE +HRDLAAR+ L+ + + KV+DFG A+ P+KW+ PE
Sbjct: 487 YLESNSFLHRDLAARHCLVGEDFSIKVSDFGMARYVLDDQYTCSQG---ARFPVKWSPPE 543
Query: 401 ALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPY 460
+FS+KSD+WSFG+++WE++S G +PY EVV V GY++ P P Y
Sbjct: 544 VFDRGRFSSKSDVWSFGVVMWEVFSEGTLPYDGWSNGEVVESVHAGYQLPQPTLAPTPVY 603
Query: 461 ELMRAAWHADPASRPTFLHMRRNLADI 487
+M W DP RP F+ + + D+
Sbjct: 604 TIMCDCWQPDPEKRPYFMKLLELITDL 630
Score = 38.7 bits (86), Expect = 0.36
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 12/103 (11%)
Query: 52 NMTQWPWHHGAISRERAEALL-SGSPDGVFLVRESTNFPGDHTL----CVRFRGRVEHYR 106
++ Q W I+R +AE LL +G FLVRES+ G T+ C+ V+HY
Sbjct: 255 DLEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRESSQV-GKLTVSVYSCIPCEV-VKHYH 312
Query: 107 VKWATAPDNQNQRLTIDDEEFFDNMTDLIHHYLQDADGLCTKL 149
VK P + + ++ F ++DLIH++ +A GL T+L
Sbjct: 313 VK--QLPTGE---WYLAEKHTFSTISDLIHYHQHNAAGLVTRL 350
>UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1;
Ciona intestinalis|Rep: Epidermal growth factor receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 878
Score = 164 bits (398), Expect = 6e-39
Identities = 98/274 (35%), Positives = 151/274 (55%), Gaps = 17/274 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGI----LNGTQKV----AVKILKDRE---AASKFRAEA 274
+ E +L I + +G G FG V G L ++V A+K+L+D A+++ EA
Sbjct: 118 VKEAELRIGKILGSGAFGTVHKGYWIPDLAPRERVKVPVAIKVLRDESSQVASNEILDEA 177
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFD 334
VMAS +H NLVRLLG+ + S L+T+ G+LL+Y+R + +Q + +N++
Sbjct: 178 FVMASCEHPNLVRLLGI--SLSQRIMLITQLMPLGNLLEYVRDNKDNIGSQ-HLLNWSLQ 234
Query: 335 ACCGMEYL-ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
GM+YL E + +VHRDLAARNVL+ + ++ DFG K+P
Sbjct: 235 IAKGMKYLSEEKHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVKEDVYRAEG--GKMP 292
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
IKW A E++++ F+ KSD+WSFG+ +WE+ +FG+ PY +P EV +ERG R+ P
Sbjct: 293 IKWLALESIQHRIFTQKSDVWSFGVTMWELMTFGKKPYESVPAREVHTLLERGERLPQPY 352
Query: 454 GCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
C Y L+ W D +RPTF + L+ +
Sbjct: 353 ICTIDIYMLLIKCWTVDAEARPTFKELTEELSKL 386
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 163 bits (396), Expect = 1e-38
Identities = 98/276 (35%), Positives = 143/276 (51%), Gaps = 20/276 (7%)
Query: 230 DLEIRENI-GKGEFGDVMLGILN----GTQKVAVKILKDREAASKFRA---EASVMASLK 281
DL++ + + G+G F V G L+ GT +VAVK +K E+ ++ ++ E SVM +LK
Sbjct: 284 DLKLNQEVFGEGSFSKVYRGTLHQMGTGTTEVAVKAMKSIESDAEMKSFFTECSVMQTLK 343
Query: 282 HENLVRLLGLVFTSSGGTCL-VTEHCAQGSLLDYLRS-RGRHYVTQLNQINFAF------ 333
H N++ +LG+ F S L V G+L DYL+ RG H + N +
Sbjct: 344 HPNVLGILGMCFDSPDSIPLMVLPFMVNGNLKDYLKKHRGPHLQLETYPENLSLQMLKRI 403
Query: 334 --DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
D GM YL +R VHRDLAARN L+ + KV DFG + K
Sbjct: 404 CVDITRGMSYLADRRFVHRDLAARNCLLDSALAVKVGDFGLTRDIYLTNYYRAPT--ETK 461
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEA 451
LP+KW PE L+ K+D+WSFG+ WE++SFG PYP + +++H+ G R++
Sbjct: 462 LPVKWMPPEMLQDGVSDEKTDVWSFGVTCWEVFSFGSTPYPGVDNHLMLQHLMSGLRLQK 521
Query: 452 PEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
P CP Y LM W ++P RPTF + + + I
Sbjct: 522 PLLCPDEIYTLMARCWSSNPEDRPTFNELFKEFSAI 557
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 162 bits (394), Expect = 2e-38
Identities = 98/291 (33%), Positives = 146/291 (50%), Gaps = 20/291 (6%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKDREAAS--- 268
++ +V +W++ + + +G+G FG V GI G K V I EAAS
Sbjct: 980 AEMYVPDKWEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRE 1039
Query: 269 --KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS--------R 318
+F EASVM ++VRLLG+V + T ++ E +G L YLRS
Sbjct: 1040 RIEFLNEASVMKEFNCHHVVRLLGVV-SQGQPTLVIMELMTRGDLKSYLRSLRPDTESNS 1098
Query: 319 GRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXX 378
G+ + I A + GM YL + VHRDLAARN +++ + T K+ DFG
Sbjct: 1099 GQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYE 1158
Query: 379 XXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAE 438
+ LP++W +PE+LK F+ SD+WSFG++LWEI + PY + +
Sbjct: 1159 TDYYRKGG--KGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQ 1216
Query: 439 VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
V+R V G +E P+ CP +ELMR W +P RP+FL + ++ D D
Sbjct: 1217 VLRFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIKDELD 1267
>UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 442
Score = 162 bits (393), Expect = 2e-38
Identities = 96/268 (35%), Positives = 138/268 (51%), Gaps = 13/268 (4%)
Query: 237 IGKGEFGDVMLGILNGTQ----KVAVKILKDREAAS-----KFRAEASVMASLKHENLVR 287
+GKG FG+V G + VAVK LK A KF E VM L H +++
Sbjct: 142 VGKGYFGNVYRGRMRDPAGRLIPVAVKTLKGERARDIAHIEKFLREGVVMKHLDHPHVLS 201
Query: 288 LLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRV 347
LLG+ + +G +V + G L Y+ R L ++FA GM YL Q
Sbjct: 202 LLGISISPAGNPWVVLPYMEGGDLKTYIADPNRALCV-LELLDFAHQVAQGMSYLAAQHF 260
Query: 348 VHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX-QAKLPIKWTAPEALKYNK 406
VHRDLAARN +ISA+ KVADFG A+LP+KW APE+L+ +
Sbjct: 261 VHRDLAARNCMISADRIVKVADFGLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRR 320
Query: 407 -FSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRA 465
FS+ +D+WSFG+L+WE+ + PY + +V ++E G R+ P CP Y+LM+
Sbjct: 321 VFSSATDVWSFGVLMWELLTRAASPYGEVSNTKVRHYLETGMRLPQPTHCPDIIYDLMQC 380
Query: 466 AWHADPASRPTFLHMRRNL-ADIRDHTP 492
W + P RP F+ + L A ++++TP
Sbjct: 381 CWRSTPEDRPDFVFLSHRLRALLQENTP 408
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 162 bits (393), Expect = 2e-38
Identities = 100/285 (35%), Positives = 142/285 (49%), Gaps = 20/285 (7%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLG----ILNGTQKVAVKILKDREAAS-----K 269
+V W++ + + +G+G FG V G I+ G + V + E+AS +
Sbjct: 1011 YVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE 1070
Query: 270 FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR--------GRH 321
F EASVM ++VRLLG+V + T +V E A G L YLRS GR
Sbjct: 1071 FLNEASVMKGFTCHHVVRLLGVV-SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRP 1129
Query: 322 YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXX 381
T I A + GM YL ++ VHRDLAARN +++ + T K+ DFG
Sbjct: 1130 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 1189
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
+ LP++W APE+LK F+ SDMWSFG++LWEI S PY + +V++
Sbjct: 1190 YRKGG--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLK 1247
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLAD 486
V G ++ P+ CP +LMR W +P RPTFL + L D
Sbjct: 1248 FVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1292
>UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor
precursor; n=4; Ascidiacea|Rep: Fibroblast growth factor
receptor precursor - Halocynthia roretzi (Sea squirt)
Length = 763
Score = 162 bits (393), Expect = 2e-38
Identities = 105/294 (35%), Positives = 153/294 (52%), Gaps = 39/294 (13%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGIL---NGTQK----VAVKILK---DREAASK 269
+D +W++ D+ + E + +G FG V L N T+K AVK+LK + +
Sbjct: 371 LDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLD 430
Query: 270 FRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR------------ 316
E M + KH+N++ LLG V T +G LV E+ AQG+L DYLR
Sbjct: 431 LLTEMDQMKRVGKHKNIINLLG-VCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLV 489
Query: 317 --SRGRH-----------YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEG 363
S GR+ +TQ + ++FAF G+E+L +++ +HRDLAARNVL++ E
Sbjct: 490 LPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEEL 549
Query: 364 TAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEI 423
K+ADFG + LP KW A EA+ N F++ +D+WSFG+LLWEI
Sbjct: 550 VMKIADFGLARDIRSCDYYRKHT--RGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEI 607
Query: 424 YSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+S PYP I E+V+ + G R++ P+ Y LMR W DP+ RP F
Sbjct: 608 FSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNF 661
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 162 bits (393), Expect = 2e-38
Identities = 98/260 (37%), Positives = 141/260 (54%), Gaps = 13/260 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL---NGTQK--VAVKILKDR---EAASKFRAEASVM 277
+ E +L+ + +G G FG V GI T K VA+KIL + +A +F EA +M
Sbjct: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
AS+ H +LVRLLG+ + + LVT+ G LL+Y+ + +QL +N+
Sbjct: 773 ASMDHPHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHKDNIGSQL-LLNWCVQIAK 829
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YLE +R+VHRDLAARNVL+ + K+ DFG K+PIKW
Sbjct: 830 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG--GKMPIKWM 887
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
A E + Y KF+++SD+WS+G+ +WE+ +FG PY IP E+ +E+G R+ P C
Sbjct: 888 ALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 947
Query: 458 GPYELMRAAWHADPASRPTF 477
Y +M W D SRP F
Sbjct: 948 DVYMVMVKCWMIDADSRPKF 967
>UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like
tyrosine kinase CG3969-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Fak-like tyrosine
kinase CG3969-PA, isoform A - Apis mellifera
Length = 1270
Score = 161 bits (392), Expect = 3e-38
Identities = 92/274 (33%), Positives = 152/274 (55%), Gaps = 14/274 (5%)
Query: 233 IRENIGKGEFGDVMLGIL--NGTQ-KVAVKILKDREAAS---KFRAEASVMASLKHENLV 286
+ + +G GEFG V G+ +G + +VA+K L + +F EA++M ++ HE++V
Sbjct: 118 VNKELGTGEFGVVQQGVWTNDGERIQVAIKCLSRERMQNNPIEFLKEAAIMYAIDHEHIV 177
Query: 287 RLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG-RHYVTQLNQINFAFDACCGMEYLERQ 345
RL G+V ++ LVTE SLL+ L+ R L+ +F+ GM+YLE +
Sbjct: 178 RLYGVVLDTNS-LMLVTELAPLRSLLECLKEPSLRSSFPVLSLCDFSVQIADGMQYLEAK 236
Query: 346 RVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX-QAKLPIKWTAPEALKY 404
R++HRDLAARN+L+ ++ K++DFG KLPI W APE + Y
Sbjct: 237 RLIHRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISY 296
Query: 405 NKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE--RGYRMEAPEGCPPGPYEL 462
KF++ SD+W++G+ LWE++S+G P+ + +++ ++ R+E PE CP + L
Sbjct: 297 LKFTSASDVWAYGVTLWEMFSYGFQPWAALTGHQILEAIDDPNFQRLEQPECCPKEYFSL 356
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
M+ W +P+ RP F + L D++ P Q+Q
Sbjct: 357 MQQCWQHEPSKRPKFSELINLLPDLK---PEQVQ 387
>UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein
kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).;
n=3; Xenopus tropicalis|Rep: Non-receptor
tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38
negative kinase 1). - Xenopus tropicalis
Length = 673
Score = 161 bits (392), Expect = 3e-38
Identities = 98/274 (35%), Positives = 145/274 (52%), Gaps = 14/274 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLG---ILNGTQKVAVKILK-----DREAASKFRAEASVM 277
I+ERDL + E +G G FG V G + + VAVK L+ D EA F E + M
Sbjct: 110 INERDLSLFERLGDGCFGVVRRGEWRVSSEGVNVAVKYLRSDACSDPEALQDFLQEVNSM 169
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGRHYVTQLNQI-NFAFDA 335
L H +L+RL G+V + +VTE GSLLD L S G L + ++
Sbjct: 170 YVLDHPHLIRLYGVVLSKP--LKMVTEIAPLGSLLDALHNSYGSCGSFSLPLLWKYSLQI 227
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM+YLE + +HRDLA RNVL+++E AK+ DFG + K+P
Sbjct: 228 ASGMKYLESYKFIHRDLATRNVLLTSEDVAKIGDFGLMRALGGHSDHYIMSTHR-KIPFA 286
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR-MEAPEG 454
W PE+LK FSN+SD+W FG+ LWE++++G+ P+ +++ ++R +E P+
Sbjct: 287 WCPPESLKIGAFSNQSDVWMFGVTLWEMFTYGQEPWMGFSGKQILLKIDRDRETLERPDD 346
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
CP YE+M+ W +P RPTF ++ L+ R
Sbjct: 347 CPQALYEVMKKCWIYEPDQRPTFANLMGLLSAAR 380
>UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep:
MBTK3 - Monosiga brevicollis
Length = 357
Score = 161 bits (392), Expect = 3e-38
Identities = 100/266 (37%), Positives = 141/266 (53%), Gaps = 9/266 (3%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAA---SKFRAEASVMASLK 281
++ DL + IG G+FG V L G Q VAVK ++ +A ++F AE+ VM +L+
Sbjct: 71 QLHRSDLIAGKPIGAGQFGQVYLAKYKGNQ-VAVKTVRQGASAEDIAEFTAESEVMLALR 129
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYV--TQLNQINFAFDACCGM 339
H LV+LLG+ C++ E G L + L++ + L Q+ FA GM
Sbjct: 130 HNCLVQLLGVSMQQRPWLCVI-EFMKYGDLREVLKTCKEKSLRLAYLEQLAFAVQISRGM 188
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
++ +QR VH DLAARNVLIS KVADFG AKLPI+W A
Sbjct: 189 AFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKT-AKLPIRWMAI 247
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE-GCPPG 458
EA+K FS KSD+W+FG+ L EI ++G +PY + +V +H+ G R+ PE G
Sbjct: 248 EAMKTKVFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGNRLAKPEDGMQDD 307
Query: 459 PYELMRAAWHADPASRPTFLHMRRNL 484
+ L + W DPA RPTF ++L
Sbjct: 308 FFALAESCWQDDPAVRPTFKEATKSL 333
>UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n=4;
Caenorhabditis|Rep: Protein kinase protein 32, isoform a
- Caenorhabditis elegans
Length = 867
Score = 161 bits (391), Expect = 4e-38
Identities = 91/278 (32%), Positives = 146/278 (52%), Gaps = 15/278 (5%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-----VAVKILK-DREAASK--FR 271
+D+ ++ + ++E IG G+FG+V + + +K VAVK+ K D E A
Sbjct: 356 IDSNIRLRRELITLKELIGGGQFGNVYKAVYHDLEKDERIAVAVKVCKTDAEPADTQLIL 415
Query: 272 AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINF 331
E+S+M + +H N+++L+G+ LV E +G L +YL+ ++ + F
Sbjct: 416 QESSLMRNFRHSNIIQLIGVCVDQP--MWLVLELAPKGELREYLQQEKDWLPLRILTL-F 472
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
C + YL R VHRD+AARN+L+ + K+ADFG + K
Sbjct: 473 CSQICDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDAVYTAS---RGK 529
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEA 451
LPIKW APE++ Y +FS SD+W FG+ +WEI+S G P+ + ++V+ H+E+G R
Sbjct: 530 LPIKWLAPESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPPC 589
Query: 452 PEGCPPGPYELMRA-AWHADPASRPTFLHMRRNLADIR 488
PE CP Y +R+ W +P RPT + + D+R
Sbjct: 590 PEKCPTALYNFIRSKMWAIEPHKRPTVDQIYAIIEDVR 627
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 161 bits (391), Expect = 4e-38
Identities = 85/277 (30%), Positives = 146/277 (52%), Gaps = 12/277 (4%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGI-LNGTQKVAV-----KILKDREAASKFRAEASVM 277
++I + + E IG+G+FGDV GI ++ +KV V K+ + +F EA +M
Sbjct: 431 YEISRELVTLVETIGQGQFGDVHKGIYIDQDEKVEVAVKTCKVESTQALGERFLEEAYIM 490
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
H ++++L+G+ + +V E G + +L++ + +T + I +A+
Sbjct: 491 KQFDHPHIIKLIGVC--TDPPIWIVMELAPFGEMRMFLQTH-KEELTLASLILYAYQLSM 547
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
+ YLE ++ VHRD+AARN+L+ A+ K+ DFG + KLPIKW
Sbjct: 548 ALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKAS---KGKLPIKWM 604
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APE++ + +F++ SD+W FG+ +WEI +G P+ + EV+ +E G R+ P CPP
Sbjct: 605 APESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPP 664
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQ 494
Y +M W +P+ RP F ++ L +I + Q
Sbjct: 665 TLYSVMTLCWSYEPSKRPNFKDLKTRLNEILEEEKEQ 701
>UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 6
SCAF14768, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1379
Score = 161 bits (390), Expect = 5e-38
Identities = 93/249 (37%), Positives = 128/249 (51%), Gaps = 9/249 (3%)
Query: 256 VAVKILK----DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
VAVK LK D + F E + M SL H+NL+RL G+V T +V E GSL
Sbjct: 212 VAVKCLKANVLDSDGLDDFIREVNAMHSLSHQNLIRLHGIVLTQP--MKMVVELAPLGSL 269
Query: 312 LDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFG 371
LD LR R H + + +A CGM YLE++R +HRDLAARNVL+S T K+ DFG
Sbjct: 270 LDRLRKRQGHILIS-SLCTYAVQVACGMSYLEQKRFLHRDLAARNVLLSTNETVKIGDFG 328
Query: 372 XXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPY 431
K+P W APE+LK FS+ SD W G+ LWE+++ G+ P+
Sbjct: 329 LMRALPTHTDQYIMEEGH-KIPFPWCAPESLKSRTFSHASDTWMIGVTLWEMFTHGQEPW 387
Query: 432 PRIPLAEVVRHVE-RGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
+ ++++ V+ R+ PE CP Y +M W P RPTF+ +R L +
Sbjct: 388 LGLNGSQILHKVDVEAERLCKPEDCPQDTYNVMLQCWSPKPEDRPTFVALRDFLLETMPT 447
Query: 491 TPAQLQLWE 499
LQ +E
Sbjct: 448 DMRALQDFE 456
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 161 bits (390), Expect = 5e-38
Identities = 97/273 (35%), Positives = 150/273 (54%), Gaps = 22/273 (8%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGIL----NGTQKVAVKILK---DREAASKFRAEASV 276
W+I + +++ +G+GEFG VM G L +KVA+K+LK DR E +
Sbjct: 1 WEIPRDRVVLKDKLGEGEFGIVMEGELLIEEEAPRKVAIKMLKSDADRTDHKDMLRELDM 60
Query: 277 MASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR-------GRHYVTQLN 327
+ +HEN+V L+G T ++TE A G+LL+ LR SR + V++L+
Sbjct: 61 FKGIGQHENVVSLIGAC-TLGMPLYIITEFIAGGTLLELLRESRCITSSYVNANLVSKLS 119
Query: 328 Q---INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
+ A A GM ++ R VHRDLA RNVL++ + TAK+ DFG
Sbjct: 120 GKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYLN 179
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
KLP+KW APE+L ++ +SD+WSFG+L+WE++SFG +PY + E++ +
Sbjct: 180 AKG--GKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLM 237
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
G+R+ P CP Y++M + W+A+P RP+F
Sbjct: 238 SGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSF 270
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 161 bits (390), Expect = 5e-38
Identities = 101/283 (35%), Positives = 147/283 (51%), Gaps = 18/283 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILK----DREAASKFRAEASVM 277
ID L + + +G+GEFG VM G L +GT KVAVK +K +F +EA+ M
Sbjct: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACM 641
Query: 278 ASLKHENLVRLLGL-VFTSSGGT---CLVTEHCAQGSLLDYLR-SR---GRHYVTQLNQI 329
H N++RLLG+ + SS G ++ G L YL SR G ++ +
Sbjct: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
Query: 330 NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ 389
F D GMEYL + +HRDLAARN ++ + T VADFG
Sbjct: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRI-- 759
Query: 390 AKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRM 449
AK+P+KW A E+L +++KSD+W+FG+ +WEI + G PYP + E+ ++ G+R+
Sbjct: 760 AKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHGHRL 819
Query: 450 EAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTP 492
+ PE C YE+M + W DP RPTF +R L + + P
Sbjct: 820 KQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP 862
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 161 bits (390), Expect = 5e-38
Identities = 96/288 (33%), Positives = 145/288 (50%), Gaps = 26/288 (9%)
Query: 220 VDARWKIDERDLEIRENIGKGEFGDVMLGILNG------TQKVAVKILK----DREAASK 269
+D W+ L + + IG+G FG V++G G T VAVK+LK DRE +
Sbjct: 628 LDPEWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDL 687
Query: 270 FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG--RHY----- 322
A + K+ N++ LLG T G ++ E G+L D+LRSR Y
Sbjct: 688 ISELAMMKMIGKNPNIINLLGCC-TQEGPPYVIVEFAHHGNLRDFLRSRRPPEEYEKSIL 746
Query: 323 ------VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXX 376
+T + ++ A+ GM++L ++ +HRDLAARNVL++ + K+ DFG
Sbjct: 747 LTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDI 806
Query: 377 XXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 436
+LP+KW APEAL F+ +SD+WSFGILLWEI + G PYP +P+
Sbjct: 807 HYIDFYRKTT--DGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPV 864
Query: 437 AEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
++ ++ G R+E P+ Y ++ W P RPTF + +L
Sbjct: 865 EQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL 912
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog
2 precursor; n=4; Coelomata|Rep: Fibroblast growth
factor receptor homolog 2 precursor - Drosophila
melanogaster (Fruit fly)
Length = 1052
Score = 161 bits (390), Expect = 5e-38
Identities = 108/309 (34%), Positives = 156/309 (50%), Gaps = 39/309 (12%)
Query: 207 TDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK--------VAV 258
TD G + + +D+ W+I + L + +G+G FG V++ G + VAV
Sbjct: 688 TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAV 747
Query: 259 KILK----DREAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLD 313
K++K D + AS R E VM + KH N++ LLG + G ++ E+ G+L D
Sbjct: 748 KMVKEEHTDTDMASLVR-EMEVMKMIGKHINIINLLGCC-SQGGPLWVIVEYAPHGNLKD 805
Query: 314 YL----------RSRGRHYVTQLNQIN-----------FAFDACCGMEYLERQRVVHRDL 352
+L RS Y+ I+ FAF GMEYL +R +HRDL
Sbjct: 806 FLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDL 865
Query: 353 AARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSD 412
AARNVL+S K+ADFG +LPIKW APE+L+ K+ ++SD
Sbjct: 866 AARNVLVSDGYVMKIADFGLARDIQDTEYYRKNT--NGRLPIKWMAPESLQEKKYDSQSD 923
Query: 413 MWSFGILLWEIYSFGRVPYPRIPLA-EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADP 471
+WS+G+LLWEI ++G PYP I A E+ ++ G RME P C Y +MR WH +
Sbjct: 924 VWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFES 983
Query: 472 ASRPTFLHM 480
+RPTF +
Sbjct: 984 CARPTFAEL 992
>UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA;
n=3; Tribolium castaneum|Rep: PREDICTED: similar to
CG14992-PA - Tribolium castaneum
Length = 1000
Score = 160 bits (389), Expect = 7e-38
Identities = 100/288 (34%), Positives = 149/288 (51%), Gaps = 18/288 (6%)
Query: 205 ASTDQTDGTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGIL---NG-TQKVAVKI 260
A+ +TD ++ F I E ++ + +G G FG V G NG VAVKI
Sbjct: 87 ATLKKTDDSVTLADFTSCL--IPESNITLSIKLGDGSFGVVRRGEWTSPNGRVLPVAVKI 144
Query: 261 LKDREAASK------FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDY 314
LK +A S+ F E M L H NL+RL G+V + +VTE GSLLDY
Sbjct: 145 LK-ADALSQPGVFEDFIKEVQAMHVLSHPNLIRLYGVVLSQP--MMMVTELANLGSLLDY 201
Query: 315 LRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXX 374
LR + + + +A GM YLE +R +HRDLA RNVL+++ K+ DFG
Sbjct: 202 LRKQCQQTPVPM-LCEYATQVATGMAYLESKRFLHRDLACRNVLLASADKIKIGDFGLMR 260
Query: 375 XXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRI 434
+ K+P W APE+L+ +FS+ SD W FG+ +WE+++FG P+ +
Sbjct: 261 ALPQEEDCYVMTEHK-KVPFPWCAPESLRSRQFSHASDTWMFGVTVWEMFTFGEDPWMGL 319
Query: 435 PLAEVVRHVER-GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMR 481
+E++R +++ G R+ PE CPP Y ++ W +P RPTF ++
Sbjct: 320 IGSEILRKIDKEGERLHQPEACPPAVYSILLQCWLKNPTERPTFAALK 367
>UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 160 bits (389), Expect = 7e-38
Identities = 81/222 (36%), Positives = 125/222 (56%), Gaps = 5/222 (2%)
Query: 265 EAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVT 324
E++ +F EA +MAS++H NL++LL + +S L+T+ G LLDY+R+ R +
Sbjct: 879 ESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRNN-RDKIG 935
Query: 325 QLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
+N++ GM YLE +R+VHRDLAARNVL+ K+ DFG
Sbjct: 936 SKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYK 995
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
K+PIKW A E ++ F++KSD+W+FG+ +WE+ +FG+ P+ IP ++ +E
Sbjct: 996 AAG--GKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1053
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLAD 486
G ++E PE C Y + + WH D A RPTF + A+
Sbjct: 1054 VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAE 1095
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 160 bits (389), Expect = 7e-38
Identities = 102/304 (33%), Positives = 152/304 (50%), Gaps = 19/304 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQ---KVAVKILK----DREAASKFRAEASVMA 278
+D + + + +G+GEFG VM G LN KVAVK +K R F +EA M
Sbjct: 524 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 583
Query: 279 SLKHENLVRLLGLVFTSSG-----GTCLVTEHCAQGSLLDYLR-SR-GRH--YVTQLNQI 329
H N++RL+G+ F S ++ G L +L SR G Y+ +
Sbjct: 584 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 643
Query: 330 NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ 389
F D GMEYL +R +HRDLAARN +++ + VADFG
Sbjct: 644 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRI-- 701
Query: 390 AKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRM 449
AK+P+KW A E+L +++KSD+WSFG+ +WEI + G+ PYP + +E+ ++ +G R+
Sbjct: 702 AKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 761
Query: 450 EAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLWELSLVVSYDLE 509
+ P C G Y LM W +P RP+F +R +L + P + E+ L V+ D
Sbjct: 762 KQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEI-LYVNMDEG 820
Query: 510 GARP 513
G P
Sbjct: 821 GGYP 824
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 160 bits (389), Expect = 7e-38
Identities = 98/293 (33%), Positives = 150/293 (51%), Gaps = 27/293 (9%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL--NGTQ-KVAVKILKDREAASK---FRAEASVMAS 279
++ D+ + IG+G FG V+ ++ +G + A+K+LK+ + + F E V+
Sbjct: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
Query: 280 LKHE-NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-----------SRGRHYVTQLN 327
L H N++ LLG + G + E+ G+LLD+LR +R + L+
Sbjct: 894 LGHHPNIINLLGAC-KNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLS 952
Query: 328 Q---INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
+ FA DA GM+YL ++ +HRDLAARNVL+ +K+ADFG
Sbjct: 953 SRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKT- 1011
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
+LP++W A E+L Y+ ++ KSD+WSFG+LLWEI S G PY + AE+ +
Sbjct: 1012 ----MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 1067
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
+GYRME P C YELMR W P RP F + L + + A + +
Sbjct: 1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM 1120
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 160 bits (388), Expect = 9e-38
Identities = 78/217 (35%), Positives = 116/217 (53%), Gaps = 1/217 (0%)
Query: 261 LKDREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGR 320
+ D E +F E +M H N++ LLG++ G +V + G L ++R R
Sbjct: 1128 ITDAEEVEQFLKEGIIMKGFHHCNVLSLLGILLPQEGLPLVVLPYMKHGDLRHFIRCEKR 1187
Query: 321 HYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXX 380
+ T + I F GMEYL +++ VHRDLAARN ++ T KVADFG
Sbjct: 1188 N-PTVKDLIGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMARDVLDKE 1246
Query: 381 XXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVV 440
+AKLP+KW A E+L+ KF+ KSD+WSFG+L+WE+ + G PYP + ++
Sbjct: 1247 YYSVQNHRKAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPYPDVDPYDIT 1306
Query: 441 RHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
++ RG R+ P+ CP Y +M W +P RP+F
Sbjct: 1307 HYLLRGRRLPQPQFCPDPLYRIMLQCWDPEPELRPSF 1343
>UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR1 precursor; n=21; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR1
precursor - Homo sapiens (Human)
Length = 937
Score = 160 bits (388), Expect = 9e-38
Identities = 103/283 (36%), Positives = 145/283 (51%), Gaps = 29/283 (10%)
Query: 235 ENIGKGEFGDVMLGIL-----NGTQKVAVKILKDR---EAASKFRAEASVMASLKHENLV 286
E +G+ FG + G L + Q VA+K LKD + ++F+ EAS+MA L H N+V
Sbjct: 477 EELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIV 536
Query: 287 RLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRH------------YVTQLNQINF--- 331
LLG V T C++ E+ QG L ++L R H + L+ +F
Sbjct: 537 CLLGAV-TQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
A GMEYL VH+DLAARN+LI + K++D G ++
Sbjct: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQS--KSL 653
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEA 451
LPI+W PEA+ Y KFS+ SD+WSFG++LWEI+SFG PY EV+ V + +
Sbjct: 654 LPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPC 713
Query: 452 PEGCPPGPYELMRAAWHADPASRPTF--LHMR-RNLADIRDHT 491
E CPP Y LM W+ P+ RP F +H+R R+ + HT
Sbjct: 714 SEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHT 756
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 159 bits (387), Expect = 1e-37
Identities = 89/248 (35%), Positives = 126/248 (50%), Gaps = 8/248 (3%)
Query: 237 IGKGEFGDVMLGI----LNGTQKVAVKILKD---REAASKFRAEASVMASLKHENLVRLL 289
IG+G FG V G L G AVK L E +F E +M H ++ LL
Sbjct: 66 IGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITYLEEVEEFLREGILMKGFHHPQVLSLL 125
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVH 349
G+ G +V + G L ++R++ R T I F GMEYL +++ VH
Sbjct: 126 GVCLPRHGLPLVVLPYMRHGDLRHFVRAQERS-PTVKELIGFGLQVALGMEYLAQKKFVH 184
Query: 350 RDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSN 409
RDLAARN ++ T KVADFG AKLP++W A E+L+ KF+
Sbjct: 185 RDLAARNCMLDETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQKFTT 244
Query: 410 KSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHA 469
KSD+WSFG+L+WE+ + G PYP + ++ R++ RG R+ P+ CP Y +M + W
Sbjct: 245 KSDVWSFGVLMWELLTRGASPYPEVDPYDMARYLLRGRRLPQPQPCPDTLYGVMLSCWAP 304
Query: 470 DPASRPTF 477
P RP+F
Sbjct: 305 TPEERPSF 312
>UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror
CG4926-PA; n=3; Endopterygota|Rep: PREDICTED: similar to
Ror CG4926-PA - Apis mellifera
Length = 529
Score = 159 bits (386), Expect = 2e-37
Identities = 95/286 (33%), Positives = 143/286 (50%), Gaps = 22/286 (7%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL---NGTQKVAVKILKD---REAASKFRAEASVMAS 279
+ L + IG+G FG V G L + + VA+K+LK+ REA F E +M++
Sbjct: 200 LQRESLAFLQEIGEGCFGKVYKGELCIGDSKEIVAIKVLKETAPREAEEDFMREVDIMST 259
Query: 280 LKHENLVRLLGLVFTSSGGT-CLVTEHCAQGSLLDYLRSRGRHY----------VTQLNQ 328
H N++ L G V + +V E+ G L + LRS R + +T+ +
Sbjct: 260 FGHRNILSLKGAVLREGNSSPWMVFEYMPYGDLAEVLRSNSRQFNRSPKPEMQPLTEESL 319
Query: 329 INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX 388
GM YL QR VHRDLA RN L+ + K+ADFG
Sbjct: 320 HWITIQIAAGMTYLSGQRFVHRDLACRNCLVGYDFIVKIADFGMSRDVYTCDYYKIKGSR 379
Query: 389 QAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPY---PRIPLAEVVRHVER 445
LPI+W +PE++ Y +F+ +SD+WSFG++LWE+YSFG+ PY +++VV+ + +
Sbjct: 380 L--LPIRWMSPESVMYGRFTLESDVWSFGVVLWEVYSFGKQPYYGHNNEEVSKVVKLIFQ 437
Query: 446 GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHT 491
G + PEGCPP ++MR W DP R F + L ++ T
Sbjct: 438 GIMLIPPEGCPPFVCQIMRECWKTDPKDRIKFPEILERLEKVKVKT 483
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 159 bits (385), Expect = 2e-37
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 20/288 (6%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGI----LNGTQKVAVKILKDREAAS--- 268
S+ ++ W++ + + +G+G FG V GI + G +V V + E+AS
Sbjct: 997 SEVYIPDEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRE 1056
Query: 269 --KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-------- 318
+F EASVM + ++VRLLG+V + T ++ E A G L YLRS
Sbjct: 1057 RIEFLNEASVMKAFNCHHVVRLLGVV-SKGQPTLVIMELMAHGDLKSYLRSLRPDAENNP 1115
Query: 319 GRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXX 378
GR T I A + GM YL ++ VHRDLAARN +++ + K+ DFG
Sbjct: 1116 GRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYE 1175
Query: 379 XXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAE 438
+ LP++W +PE+LK F+ SD+WSFG++LWEI S PY + +
Sbjct: 1176 TDYYRKGG--KGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQ 1233
Query: 439 VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLAD 486
V++ V G ++ PE CPP + LM+ W +P RPTFL + L D
Sbjct: 1234 VLKFVMDGGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKD 1281
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 158 bits (384), Expect = 3e-37
Identities = 96/293 (32%), Positives = 150/293 (51%), Gaps = 27/293 (9%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILN---GTQKVAVKILKDREAASK---FRAEASVMAS 279
++ D++ + IG+G FG V+ ++ A+K+LK+ + + F E V+
Sbjct: 674 LEWEDIKFEDVIGEGNFGQVIKAMVKKDGNKMSAAIKMLKEFASENDHRDFAGELEVLCK 733
Query: 280 L-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR---------GRH----YVT 324
L +H N++ L+G + G + E+ G+LLD+LR SR H +T
Sbjct: 734 LGQHPNIINLIGAC-ENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAKEHGTASTLT 792
Query: 325 QLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
+ FA D GM YL ++ +HRDLAARNVL+ AK+ADFG
Sbjct: 793 SQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRGEEVYVKKT- 851
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
+LP++W A E+L Y+ ++ KSD+WSFG+LLWEI S G PY + AE+ +
Sbjct: 852 ----MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 907
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
+G+RME P+ C YELM+ W P RP F + L+ +++ A + +
Sbjct: 908 QGFRMEKPKNCDDEVYELMKQCWRDRPYERPPFSQISVQLSRMQEARKAYVNM 960
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor -
Aplysia californica (California sea hare)
Length = 1145
Score = 158 bits (384), Expect = 3e-37
Identities = 96/297 (32%), Positives = 141/297 (47%), Gaps = 29/297 (9%)
Query: 230 DLEIRENIGKGEFGDVMLGILNG------TQKVAVKILKDR---EAASKFRAEASVMASL 280
++ + +G+G FG V G L G VA+K LK+ + + FR E +M+ +
Sbjct: 570 NIRFLQELGEGAFGKVYKGELVGLYGESSVTTVAIKTLKENALPKVQNDFRREVDLMSDM 629
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR----------------GRHYVT 324
+H N+V LLG+ C++ E+ AQG L +YL S G H +
Sbjct: 630 RHPNIVCLLGVCMKQEP-MCMLFEYMAQGDLHEYLLSHSPHSDVTAAEDDSGTGGGHILE 688
Query: 325 QLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
++ + GMEYL VHRDLAARN+L++ T K++DFG
Sbjct: 689 YSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILVADGLTVKISDFGLSRDVYSSDYYRV 748
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
++ LP++W PEA+ Y KF+ SD+W+FG++LWE++S+G PY EV+ +
Sbjct: 749 QS--KSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYYGFSNQEVIEMIR 806
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLWELS 501
+ PE CP Y LM WH PA RP F + L R W LS
Sbjct: 807 SRQILGCPEECPARIYGLMVECWHEMPARRPPFREIHTRLRTWRSELTTS-NPWSLS 862
>UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 903
Score = 158 bits (384), Expect = 3e-37
Identities = 116/313 (37%), Positives = 159/313 (50%), Gaps = 55/313 (17%)
Query: 224 WKIDERDLEIREN--IGKGEFGDVMLGILNGTQ--------------------KVAVKIL 261
W+I+ R+L I + +G G FG V LG L G +VAVK+L
Sbjct: 534 WEIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKML 593
Query: 262 K---DREAASKFRAEASVMASLK-HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS 317
D + +F E ++M +L HE LV +L V T S CLV E+C G LL +LR
Sbjct: 594 PEYADEMSKHEFLREIALMKTLGYHERLVNMLACV-TESEPLCLVVEYCDNGDLLKFLRE 652
Query: 318 R----------GRHY--------------VTQLNQINFAFDACCGMEYLERQRVVHRDLA 353
R G +Y VT + FA G+EYL ++ VHRD+A
Sbjct: 653 RCKYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVA 712
Query: 354 ARNVLISAEGTA-KVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSD 412
ARNVL+ EGTA K+ DFG KLP+KW +PEA+++ +FS KSD
Sbjct: 713 ARNVLVH-EGTACKIGDFGLCRYIYADQSQYKSKG--GKLPLKWMSPEAIRHYEFSIKSD 769
Query: 413 MWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPA 472
+WSFGILL+E+ + G PYP +P +V+ +E G R+E P+ CP Y++M W+ADP
Sbjct: 770 IWSFGILLFEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPD 829
Query: 473 SRPTFLHMRRNLA 485
R F +R LA
Sbjct: 830 DRIEFSDVRMQLA 842
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 158 bits (383), Expect = 4e-37
Identities = 95/256 (37%), Positives = 135/256 (52%), Gaps = 18/256 (7%)
Query: 237 IGKGEFGDVMLGILNGTQK----VAVKILKD---REAASKFRAEASVMASLKHENLVRLL 289
+G+G FG+V G+ ++ VAVK L +A + F EA +M+ +H N+V+ +
Sbjct: 926 LGQGAFGEVFQGVYKYSRSEEHPVAVKTLPSVSTSQAEADFMMEALIMSKFEHPNIVQFI 985
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRS-RGRH----YVTQLNQINFAFDACCGMEYLER 344
G+ F +V E A G L ++LR R R +T + I A+D G +Y+E
Sbjct: 986 GISFDKHP-RYIVLELLAGGDLKNFLREERPRPDRPTTLTMQSLIMCAYDVAKGCKYMEE 1044
Query: 345 QRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
R +HRD+AARN L+S +G K+ADFG +A LPIKW PE+
Sbjct: 1045 ARFIHRDIAARNCLLSCKGPGRVVKIADFGMARDIYRSDYYRKGG--KAMLPIKWMPPES 1102
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
F+ K+D+W+FG+LLWEI SFG +PY EV+ V G R+E P GCP Y
Sbjct: 1103 FLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANREVMSMVTSGGRLERPAGCPDPIYG 1162
Query: 462 LMRAAWHADPASRPTF 477
+M WH P RP+F
Sbjct: 1163 IMTRCWHPHPEERPSF 1178
>UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic
lymphoma kinase (Ki-1),; n=1; Danio rerio|Rep: PREDICTED:
similar to anaplastic lymphoma kinase (Ki-1), - Danio
rerio
Length = 1387
Score = 158 bits (383), Expect = 4e-37
Identities = 93/270 (34%), Positives = 139/270 (51%), Gaps = 20/270 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGT------QKVAVKILKD---REAASKFRAEAS 275
++ R++ + +G G FG+V G+ G +VAVK L + + F EA
Sbjct: 789 EVPRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLMEAL 848
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS---RGRH--YVTQLNQIN 330
+++ H+N+VR +G+ + L+ E A G L +LR R H +T ++ +N
Sbjct: 849 IISKFSHQNIVRCIGVSLQALPHFILL-ELMAGGDLKSFLRETRPRLEHPSSLTMVDLLN 907
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXX 387
A D G +YLE + +HRD+AARN L++ +G AK+ DFG
Sbjct: 908 IARDIARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGG- 966
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
+A LP+KW PEA F++K+D WSFG+LLWEI+S G +PYP EV+ V G
Sbjct: 967 -RAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGG 1025
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
RM+ P+ CP Y +M +W P RP F
Sbjct: 1026 RMDPPKNCPGPVYRIMTQSWQHQPEDRPNF 1055
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 158 bits (383), Expect = 4e-37
Identities = 91/266 (34%), Positives = 140/266 (52%), Gaps = 10/266 (3%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-KVAVKILKDREAAS---KFRAEA 274
+V+ W+ID D+EI +GKG FG V G++ Q A+K + ++ + S +F E
Sbjct: 908 YVEDDWEIDRNDIEIIRELGKGSFGTVYEGLIKSRQYPCAIKTISEKSSISSKMEFLNEG 967
Query: 275 SVMASLKH-ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS-RGRHYVTQLNQI-NF 331
SVM S ++++LLG+V + ++ E +G L YLR RG N+I
Sbjct: 968 SVMKSFSETHHVIKLLGIV-SRGDRPFVIMELMERGDLKSYLRRCRGPSQNLTTNEIYRM 1026
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
A + GM YL ++ VHRDLAARN +++A+ T K+ DFG
Sbjct: 1027 ASEIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMARDIYETDYYRKGTA--GL 1084
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEA 451
LPI+W APE+L F+ SD+WS+G++LWE+ + +PY + EV++ V G ++
Sbjct: 1085 LPIRWMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGAEEVLQFVTSGRTLDM 1144
Query: 452 PEGCPPGPYELMRAAWHADPASRPTF 477
P C +++M A W P RPTF
Sbjct: 1145 PPQCSDLLHKIMSACWKWRPNDRPTF 1170
>UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47;
Euteleostomi|Rep: Protein tyrosine kinase 2 beta - Homo
sapiens (Human)
Length = 1009
Score = 158 bits (383), Expect = 4e-37
Identities = 86/272 (31%), Positives = 143/272 (52%), Gaps = 13/272 (4%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ----KVAVKILKDR---EAASKFRAEAS 275
++ I D+ + +G+G FG+V G+ + VAVK K + KF +EA
Sbjct: 417 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 476
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
+M +L H ++V+L+G++ T ++ E G L YL R ++ + L + ++
Sbjct: 477 IMKNLDHPHIVKLIGII--EEEPTWIIMELYPYGELGHYLE-RNKNSLKVLTLVLYSLQI 533
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
C M YLE VHRD+A RN+L+++ K+ DFG +LPIK
Sbjct: 534 CKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVT---RLPIK 590
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGC 455
W +PE++ + +F+ SD+W F + +WEI SFG+ P+ + +V+ +E+G R+ P+ C
Sbjct: 591 WMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLC 650
Query: 456 PPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
PP Y LM W DP+ RP F + +L+D+
Sbjct: 651 PPVLYTLMTRCWDYDPSDRPRFTELVCSLSDV 682
>UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to
tyrosine-protein kinase pr2; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to tyrosine-protein
kinase pr2 - Nasonia vitripennis
Length = 1345
Score = 157 bits (382), Expect = 5e-37
Identities = 90/274 (32%), Positives = 150/274 (54%), Gaps = 14/274 (5%)
Query: 233 IRENIGKGEFGDVMLGIL--NGTQ-KVAVKILKDREAAS---KFRAEASVMASLKHENLV 286
+ + +G GEFG V G+ +G + +VA+K L + +F EA++M S+ HE++V
Sbjct: 176 VNKELGTGEFGVVQQGVWTNDGERIQVAIKCLSRERMQNNPIEFLKEAAIMHSIDHEHIV 235
Query: 287 RLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI-NFAFDACCGMEYLERQ 345
RL G+V ++ LVTE SLL+ L+ + + +F+ GM+YLE +
Sbjct: 236 RLYGVVLDTNS-LMLVTELAPLRSLLECLKEPSLRASFPVPSLCDFSVQIADGMQYLEAK 294
Query: 346 RVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX-QAKLPIKWTAPEALKY 404
R++HRDLAARN+L+ ++ K++DFG KLPI W APE + Y
Sbjct: 295 RLIHRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISY 354
Query: 405 NKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG--YRMEAPEGCPPGPYEL 462
KF++ SD+W++G+ LWE++S+G P+ + +++ ++ R+E P+ CP + L
Sbjct: 355 LKFTSASDVWAYGVTLWEMFSYGFQPWAALTGHQILEAIDEPNFQRLEQPDCCPKDYFSL 414
Query: 463 MRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
M+ W +P RP F + L D++ P Q+Q
Sbjct: 415 MQQCWQHEPTKRPKFSELICLLPDLK---PEQVQ 445
>UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF5507, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1116
Score = 157 bits (382), Expect = 5e-37
Identities = 90/224 (40%), Positives = 124/224 (55%), Gaps = 7/224 (3%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK-DREAA-SKFRAEASVMASLK 281
W++ +++ E+ E +G G F V G +VAVKILK D E F+ E ++ +L+
Sbjct: 824 WELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKSDSELNHGDFQTEVQILKNLR 883
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H +L+ L V T S ++TE +GSLL +LRS + I+ GM Y
Sbjct: 884 HRHLLSLFA-VCTESRPYWIITELMEKGSLLIFLRSPEGQNQDVASLIDMGTQVADGMSY 942
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
LE Q+ +HRDLAARNVL+ + T KV DFG K+P KWTAPEA
Sbjct: 943 LEEQKSIHRDLAARNVLVGEDYTCKVGDFGLARVIKEPFYITE----DKKIPYKWTAPEA 998
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER 445
+ + KFSNKSD+WSFGILL+EI ++G VPYP + H +R
Sbjct: 999 ISHGKFSNKSDVWSFGILLYEITTYGGVPYPGALFSRSWSHDQR 1042
Score = 139 bits (337), Expect = 1e-31
Identities = 78/220 (35%), Positives = 117/220 (53%), Gaps = 6/220 (2%)
Query: 214 LQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNG-TQKVAVKILKDREAAS-KFR 271
LQ + F W+ + + +G+G FG+V + + ++VA+K LK + +F
Sbjct: 355 LQRELFDMEPWERPREEFRLLRKLGEGHFGEVWEALWSTENRRVAIKTLKQEDTKQDEFV 414
Query: 272 AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINF 331
E + SL H L++LL + + +VTE +GSL YL S +T + I
Sbjct: 415 KEVQALKSLHHPKLIQLLAMC-SRGEPVYIVTELMTKGSLKAYLASAEGQVLTSAHLIYM 473
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAK 391
GM YLE + +VHRDLAARN+L+ + KVADFG K
Sbjct: 474 GSQIAEGMAYLEDRNIVHRDLAARNILVGEDLVCKVADFGLARIIKDSVYTASR---NTK 530
Query: 392 LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPY 431
+P++WTAPEA + +FS KSD+WSFG+LL+E+ S G++PY
Sbjct: 531 IPVRWTAPEAAIHQRFSVKSDVWSFGVLLYEMMSRGKMPY 570
Score = 48.8 bits (111), Expect = 3e-04
Identities = 28/68 (41%), Positives = 41/68 (60%), Gaps = 4/68 (5%)
Query: 43 PPPAGNRLVNMTQWPWHHGAISRERAEALL--SGSPDGVFLVRESTNFPGDHTLCVRFRG 100
P P G L T PW++G I+R +AE LL S + DG FLVR S + ++T+ R G
Sbjct: 237 PDPLGTSL-GWTG-PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEG 294
Query: 101 RVEHYRVK 108
+V H+R++
Sbjct: 295 KVFHFRIQ 302
Score = 42.7 bits (96), Expect = 0.022
Identities = 19/47 (40%), Positives = 25/47 (53%)
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
E + V GYRM AP CP Y++M W A+P RP F ++ L
Sbjct: 1067 EAYQQVTAGYRMPAPAKCPHFLYQIMLKCWAAEPDDRPDFRTLKVEL 1113
Score = 38.3 bits (85), Expect = 0.48
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 7/84 (8%)
Query: 57 PWHHGAISRERAEA--LLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVEHYRVKWATAPD 114
PW G ++R +A++ L + +G FL+R S + L VR +V+HY+V
Sbjct: 68 PWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKV----LQT 123
Query: 115 NQNQRLTIDDEEFFDNMTDLIHHY 138
+QN R ++ F ++ +L+ +Y
Sbjct: 124 DQN-RFYVEPGRRFSSLAELVDYY 146
Score = 34.3 bits (75), Expect = 7.8
Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK 269
W++ +++ E+ E +G G F V G +VAVKILK A SK
Sbjct: 179 WELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKS-AAVSK 223
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 157 bits (380), Expect = 9e-37
Identities = 101/279 (36%), Positives = 146/279 (52%), Gaps = 20/279 (7%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGI----LNGTQKV--AVKILK----DRE 265
S +V W++ +E+ ++G G FG V GI + G +V AVK + DRE
Sbjct: 315 STPYVLDEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRE 374
Query: 266 AASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG-----R 320
+F EASVM ++V+LLG+V T T ++ E G L YLRS
Sbjct: 375 RI-EFLNEASVMKGFDAHHVVKLLGVV-TRGQPTLVIMELMVNGDLKRYLRSHRPCENMS 432
Query: 321 HYVTQLNQI-NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+ +L++I A + GM YL ++ VHRDLAARN +++ + T KV DFG
Sbjct: 433 NAPPKLDRILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMTRDIYER 492
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
+ LP++W APE+LK FS+ SD+WS+G++LWE+ +F PY + +V
Sbjct: 493 DYYRKGS--KGLLPVRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGLSNEQV 550
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFL 478
+R+V G ME PE CP YELM+ W RPTF+
Sbjct: 551 LRYVIEGGVMERPENCPELLYELMKRTWRHKATRRPTFM 589
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 157 bits (380), Expect = 9e-37
Identities = 97/299 (32%), Positives = 150/299 (50%), Gaps = 22/299 (7%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-----KVAVKILKDREAASK---F 270
+V W++ + +E+ +G+G FG V GI + K AVK + + + F
Sbjct: 968 YVPDEWEVPRKKIELIRELGQGSFGMVYEGIAQDVRGKAQIKCAVKTVNEHATNRERLEF 1027
Query: 271 RAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-----------G 319
EASVM + ++VRLLG+V + T ++ E A G L YLRS
Sbjct: 1028 LNEASVMKAFDTAHVVRLLGVV-SQGQPTLVIMELMANGDLKTYLRSHRPDAEVYDPATA 1086
Query: 320 RHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+ T + A + GM YL ++ VHRDLAARN +++ + T K+ DFG
Sbjct: 1087 KQPPTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYET 1146
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
+ LP++W APE+LK F++ SD+WS+G++LWE+ + PY + +V
Sbjct: 1147 DYYRKGT--KGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGLSNDQV 1204
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLW 498
+R+V G ME PE CP Y LMR W P++RP+FL + L + + AQ+ +
Sbjct: 1205 LRYVIDGGVMERPENCPDKLYTLMRYCWQHKPSARPSFLKLCSLLLEDASTSFAQVSFY 1263
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 157 bits (380), Expect = 9e-37
Identities = 81/213 (38%), Positives = 116/213 (54%), Gaps = 5/213 (2%)
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHC-AQGSLLDYLRSRGRHYVTQLNQINFAFD 334
++ H N+V+L+G V T +V E G L +LR++GR + + A +
Sbjct: 710 ILKQYDHPNVVKLIG-VCTQKQPIYIVMELIQGSGDFLTFLRNQGRDLKPKA-LVKMAEN 767
Query: 335 ACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPI 394
GM YLE ++ +HRDLAARN L++ + K++DFG Q +PI
Sbjct: 768 VASGMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQDDDGVYLAEGGLRQ--IPI 825
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG 454
KWTAPEAL Y +++ +SD+WSFGILLWE +S G PY + + VE+GYRM AP
Sbjct: 826 KWTAPEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEVEKGYRMPAPHA 885
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
CP +M W DP +RP+F +R L+ I
Sbjct: 886 CPVEIARIMNNCWQYDPQNRPSFKKLRAELSAI 918
Score = 44.4 bits (100), Expect = 0.007
Identities = 32/95 (33%), Positives = 47/95 (49%), Gaps = 11/95 (11%)
Query: 45 PAGNRLVN-MTQWPWHHGAISRERAEALLSGSPDGVFLVRESTNFPGDHTLCVRFRGRVE 103
P G + + Q W+HGAI R + LL + DG FLVR+S PG + L V + G +
Sbjct: 514 PVGQEVERPLEQQTWYHGAIPRLEVQQLL--TKDGDFLVRKSQEKPG-YVLSVHWSGACK 570
Query: 104 HYRVKWATAPDNQNQRLTIDDEEFFDNMTDLIHHY 138
H+ V+ N++ +D E F + LI Y
Sbjct: 571 HFLVQ------NKDNMYCLDGES-FHTIPQLIQQY 598
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 157 bits (380), Expect = 9e-37
Identities = 104/327 (31%), Positives = 167/327 (51%), Gaps = 42/327 (12%)
Query: 196 FPHAYVAPAASTDQTDGTLQSQSFVDA-------RWKIDERDLEIRENIGKGEFGDVMLG 248
FP +Y + A D ++++Q VDA +W+ ++L + + +G+GEFG V+
Sbjct: 683 FPVSYSSSGARRPSLD-SMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKA 741
Query: 249 IL------NGTQKVAVKILKDREAASKFR---AEASVMASLKHENLVRLLGLVFTSSGGT 299
G VAVK+LK+ + S+ R +E +V+ + H ++++L G + G
Sbjct: 742 TAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC-SQDGPL 800
Query: 300 CLVTEHCAQGSLLDYLR-SR--GRHYV-------------------TQLNQINFAFDACC 337
L+ E+ GSL +LR SR G Y+ T + I+FA+
Sbjct: 801 LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQ 860
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM+YL ++VHRDLAARN+L++ K++DFG Q ++P+KW
Sbjct: 861 GMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS--QGRIPVKWM 918
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
A E+L + ++ +SD+WSFG+LLWEI + G PYP IP + ++ G+RME P+ C
Sbjct: 919 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSE 978
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNL 484
Y LM W +P RP F + ++L
Sbjct: 979 EMYRLMLQCWKQEPDKRPVFADISKDL 1005
>UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n=2;
Danio rerio|Rep: UPI00015A61DF UniRef100 entry - Danio
rerio
Length = 985
Score = 156 bits (379), Expect = 1e-36
Identities = 87/264 (32%), Positives = 136/264 (51%), Gaps = 12/264 (4%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ----KVAVKILKDREA--ASKFRAEASV 276
++ I D+ + +G+G FG+V GI VAVK KD A KF +EA +
Sbjct: 354 KFSISRNDIVLGRILGEGFFGEVHDGIYKSKSGERVNVAVKTCKDCSADVKEKFMSEALI 413
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC 336
M L H ++VRL+G++ +V E G L +YL+ ++ +T + I ++
Sbjct: 414 MKKLDHPHIVRLIGII--EEDPVWIVMELYPFGELENYLKDN-QNKLTNVTLILYSLQIS 470
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
+ YLE +VHRD+A RNVL++ K+ DFG +LPIKW
Sbjct: 471 KALAYLEGVNMVHRDIAVRNVLVAKVDCVKLGDFGLSRYIEEEEYYKASVT---RLPIKW 527
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
APE++ + +F++ SD+W F + +WEI S G+ P+ + +V+ +E+G R+ PE CP
Sbjct: 528 MAPESINFRRFTSASDVWMFAVCMWEIMSGGQQPFFWLENKDVINQLEQGMRLPKPERCP 587
Query: 457 PGPYELMRAAWHADPASRPTFLHM 480
P Y LM W P RP+F +
Sbjct: 588 PTLYSLMTRCWSYSPRDRPSFTEL 611
>UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase
erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4).; n=1; Takifugu
rubripes|Rep: Receptor tyrosine-protein kinase erbB-4
precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4). - Takifugu
rubripes
Length = 1236
Score = 156 bits (379), Expect = 1e-36
Identities = 96/260 (36%), Positives = 140/260 (53%), Gaps = 13/260 (5%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL--NGTQ---KVAVKILKDR---EAASKFRAEASVM 277
+ E +L+ + +G G FG V GI G + VAVKIL + +A +F EA +M
Sbjct: 665 LKETELKRVKVLGSGAFGTVYKGIWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIM 724
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACC 337
AS++H +LVRLLG+ + + LVT+ G LLDY+ + +QL +N+
Sbjct: 725 ASMEHPHLVRLLGVCLSPT--IQLVTQLMPHGCLLDYVHEHKDNIGSQL-LLNWCVQIAK 781
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YLE +R+VHRDLAARNVL+ + K+ DFG K+ IKW
Sbjct: 782 GMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDVNEKEYNADG--GKMAIKWM 839
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
A E + Y KF+++SD+WS+G+ +WE+ +FG PY I ++ +E+G R+ P C
Sbjct: 840 ALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTI 899
Query: 458 GPYELMRAAWHADPASRPTF 477
Y +M W D SRP F
Sbjct: 900 DVYMVMVKCWMIDADSRPKF 919
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 156 bits (379), Expect = 1e-36
Identities = 92/268 (34%), Positives = 141/268 (52%), Gaps = 15/268 (5%)
Query: 229 RDLEIREN--IGKGEFGDVMLGIL-----NGTQKVAVK-ILKDR--EAASKFRAEASVMA 278
+D E+R+ +G G FG V G+ N VA+K +LK E++ +F EA +MA
Sbjct: 833 KDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMA 892
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
++LL + +S L+T+ G LLDY+R+ R + +N++ G
Sbjct: 893 XXXXXXXLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRNN-RDKIGSKALLNWSTQIAKG 949
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YLE +R+VHRDLAARNVL+ K+ DFG K+PIKW A
Sbjct: 950 MSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG--GKMPIKWLA 1007
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
E ++ F++KSD+W+FG+ +WE+ +FG+ P+ IP ++ +E G ++E PE C
Sbjct: 1008 LECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLD 1067
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLAD 486
Y + + WH D A RPTF + A+
Sbjct: 1068 IYCTLLSCWHLDAAMRPTFKQLTTVFAE 1095
>UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=2;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor c - Nematostella vectensis
Length = 297
Score = 156 bits (379), Expect = 1e-36
Identities = 107/287 (37%), Positives = 145/287 (50%), Gaps = 29/287 (10%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNG----TQKVAVKILK---DREAASKFRAEASVMA 278
I ++ + E +G GEFG V G + T AVK +K EA E +M
Sbjct: 11 IPTSNIILHEYLGSGEFGVVTRGEMTTDDGRTVDCAVKSIKGFASEEALRDLVQELELMH 70
Query: 279 SL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYL-RSRG-------------RHYV 323
S+ H NL+ L+G T S ++ E G LLD L ++RG RH
Sbjct: 71 SVGHHRNLLNLIGAC-TDSEKLMIIVEFANDGCLLDLLHQARGDLQSPRIYQNIEPRHSE 129
Query: 324 TQLNQ---INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXX 380
L Q + A D GM+YL +R VHRDLAARNVLI A+G AKVADFG
Sbjct: 130 VVLGQTRRLEIALDVAQGMDYLASKRCVHRDLAARNVLI-ADGVAKVADFGLSRNIYETG 188
Query: 381 XXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVV 440
+ KLP +W + E+L+ KF+ +SD+WS+G+LLWEI + G P + E++
Sbjct: 189 EYEKTT--RGKLPTRWMSLESLETRKFTLESDVWSYGVLLWEIETRGLTPNAGLNYREMI 246
Query: 441 RHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
+GYR+E P C G YE+MR W A P SRPTF + L ++
Sbjct: 247 ARYRKGYRLERPPDCDQGLYEIMRRCWLAIPKSRPTFSDIVEQLTEL 293
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 156 bits (379), Expect = 1e-36
Identities = 93/276 (33%), Positives = 141/276 (51%), Gaps = 20/276 (7%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK-------VAVKILKDREAAS--- 268
++ W++D +++ + +G+G FG V G+ G + VAVK + DR + S
Sbjct: 1025 YISDEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRR 1084
Query: 269 KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-------GRH 321
+F EA+ M ++V+LLG+V T ++ E A G L +YLR G
Sbjct: 1085 EFLKEATTMKEFHCHHVVKLLGVVSTGQPAL-VIMELMALGDLKNYLRGHRPDEDHPGVM 1143
Query: 322 YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXX 381
L+ + A + GM YL ++ VHRDLAARN ++S E T K+ DFG
Sbjct: 1144 PPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIYETDY 1203
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
+ LP++W APE+LK F++ SD+WS+G+++WE+ + PY + EVV+
Sbjct: 1204 YRKGG--KGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEVVK 1261
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+ GY ME PE CP LM+ W P RPTF
Sbjct: 1262 FISDGYIMELPENCPNEMAYLMQHCWAKKPNQRPTF 1297
>UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosine
kinase, non-recepTor, 2 isoform 1; n=1; Takifugu
rubripes|Rep: Homolog of Homo sapiens "Tyrosine kinase,
non-recepTor, 2 isoform 1 - Takifugu rubripes
Length = 767
Score = 156 bits (378), Expect = 2e-36
Identities = 85/264 (32%), Positives = 139/264 (52%), Gaps = 9/264 (3%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASKFRAEASVMASLKHENL 285
I + +L + E +G G FG + + + V+ + + + F E + M +L H N+
Sbjct: 145 IQDGELLLGEKLGSGSFGVLTVAVKTLRNSVS----RQTDTLTDFLQEVTTMQALDHPNI 200
Query: 286 VRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQ 345
+RL G+V T +VTE + GSL D LR+R Y + FA GM+YLE +
Sbjct: 201 IRLYGVVLTQP--LKMVTELASLGSLYDTLRARQFEYPLVRLWL-FATQIASGMDYLETR 257
Query: 346 RVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYN 405
R++HRDLAARN+L+++ K+ DFG + ++P W APE+L+
Sbjct: 258 RLIHRDLAARNILLASREMVKIGDFGLMRGLSQEVDHYVMSAHR-RIPFAWCAPESLRVG 316
Query: 406 KFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEGCPPGPYELMR 464
FS+ SD+W FG+ +WE++++ P+ + +++ VER G R+E P CP Y +MR
Sbjct: 317 SFSHSSDVWMFGVTMWEMFTYCEEPWFGLTGRQILWRVEREGERLEKPPDCPQELYVVMR 376
Query: 465 AAWHADPASRPTFLHMRRNLADIR 488
W +P RP F + +A+ +
Sbjct: 377 KCWACNPNDRPNFSQLGMLVAEAK 400
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 156 bits (378), Expect = 2e-36
Identities = 94/273 (34%), Positives = 138/273 (50%), Gaps = 22/273 (8%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-----KVAVKILKDR---EAASKFRAEA 274
R ++D+ + +G G FG+V G++ G +VA+K LK +F EA
Sbjct: 1797 RIRLDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEA 1856
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY------VTQLNQ 328
+M++ KH+++ RLLG V + ++ E G LL YLR R R +T L+
Sbjct: 1857 QLMSNFKHKHITRLLG-VCLEADALLIIMELMQGGDLLSYLR-RSRSLPGQAARLTMLDL 1914
Query: 329 INFAFDACCGMEYLERQRVVHRDLAARNVLISA----EGTAKVADFGXXXXXXXXXXXXX 384
I+ D G YLE VHRDLA RN L+S+ + K+ DFG
Sbjct: 1915 ISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRK 1974
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
+ LP++W +PE+L F+++SD+W+FG+LLWEI + G PY EV+ HV
Sbjct: 1975 EG--EGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVR 2032
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
G ++ P+ CP YELM+ W P RPTF
Sbjct: 2033 EGGHLDRPKVCPNEMYELMKYCWKFSPEERPTF 2065
>UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1084
Score = 155 bits (377), Expect = 2e-36
Identities = 91/270 (33%), Positives = 137/270 (50%), Gaps = 20/270 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQ------KVAVKILKD---REAASKFRAEAS 275
++ R++ + +G G FG+V G+ G +VAVK L + + F EA
Sbjct: 493 EVSRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEAL 552
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS---RGRH--YVTQLNQIN 330
+++ H+N+VR +G+ + L+ E G L ++R R H +T ++ +N
Sbjct: 553 IISKFSHQNIVRCVGVSLQAMPRFILL-ELMTGGDLKTFMRETRPRPEHPSSLTMVDLLN 611
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXX 387
A D G +YLE + +HRD+AARN L++ +G AK+ DFG
Sbjct: 612 IARDIAKGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGG- 670
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
+A LP+KW PEA F++K+D WSFG+LLWEI+S G +PYP EV+ V G
Sbjct: 671 -RAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGG 729
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
RM+ P+ CP Y +M W P RP F
Sbjct: 730 RMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 759
>UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 1193
Score = 155 bits (377), Expect = 2e-36
Identities = 95/289 (32%), Positives = 151/289 (52%), Gaps = 16/289 (5%)
Query: 228 ERDLEIRENIGKGEFGDVMLGILN-----GTQKVAVKILKDREAASKFRAE----ASVMA 278
E LE + +G G FG V G +VA+K+LK+ A + + E +VMA
Sbjct: 838 ETALEQGQVLGSGAFGTVYKGHWRPEGDPNCYEVAIKVLKEETATPQSQTELLREGAVMA 897
Query: 279 SLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCG 338
++ H N+VRL + L+TE GSLL YL++ + + + +NF+ G
Sbjct: 898 TMDHINVVRLYCVCMGKQ--MMLITEFVRLGSLLSYLKNN-QATLDAYSMLNFSRQIADG 954
Query: 339 MEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTA 398
M YLE +R+VHRDLAARNVL+ K+ DFG +P++W A
Sbjct: 955 MAYLEEKRMVHRDLAARNVLVHTPQLVKITDFGLTRIIDVGESHYKATGGM--VPLRWMA 1012
Query: 399 PEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPG 458
PE++ ++++KSD+WSFG+ +WEI +FGR+PY EV + V+ G ++E P C
Sbjct: 1013 PESIFLFEYTHKSDVWSFGVTIWEILTFGRLPYKGKNGKEVSQLVKNGQQLERPATCDAN 1072
Query: 459 PYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLWELSLVVSYD 507
Y L+ W D RP+F + +L ++ + P + + +++V SY+
Sbjct: 1073 LYHLLEQCWLHDQTKRPSFSALSNSL-NVMLNDPTR-YIQTVAMVASYE 1119
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 155 bits (377), Expect = 2e-36
Identities = 91/258 (35%), Positives = 134/258 (51%), Gaps = 20/258 (7%)
Query: 237 IGKGEFGDVMLGILNGT-----QKVAVKILKD---REAASKFRAEASVMASLKHENLVRL 288
+G G FG+V GI+ G +VA+K L+ + ++F EA +M++ KH+++++L
Sbjct: 1818 LGSGAFGEVYEGIVKGVGGEAETRVAIKTLRKGATEQEKAEFLQEAHLMSNFKHKHILKL 1877
Query: 289 LGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-----GRHYVTQLNQINFAFDACCGMEYLE 343
+G V +V E G LL YLRS +T L+ I+ D G YLE
Sbjct: 1878 IG-VCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLDLISMCVDVATGCRYLE 1936
Query: 344 RQRVVHRDLAARNVLISA----EGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
VHRDLA RN L+S+ E K+ DFG + LP++W +P
Sbjct: 1937 EMHFVHRDLACRNCLVSSMDPRERVVKIGDFGLARDIYKNDYYRKEG--EGLLPVRWMSP 1994
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGP 459
E+L F+++SD+W+FG+LLWEI + G+ PYP EV+ +V G R+ P+ CP
Sbjct: 1995 ESLVDGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNVEVLHYVRDGGRLTRPQDCPEEL 2054
Query: 460 YELMRAAWHADPASRPTF 477
Y+LM W P RPTF
Sbjct: 2055 YQLMLKCWSYSPEDRPTF 2072
>UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 438
Score = 155 bits (377), Expect = 2e-36
Identities = 102/278 (36%), Positives = 145/278 (52%), Gaps = 17/278 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILN---GTQ-KVAVKILK-DREAA-----SKFRAEAS 275
I E L + E IG G FG V G GT+ VAVK LK +AA + F EA+
Sbjct: 111 ITESSLVLYEMIGDGAFGYVRKGQWTTDTGTKVDVAVKCLKFSADAAFIQMQTDFIKEAN 170
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDA 335
MA L H +++RL G+V ++ LVTE G LL LR+ + ++ +F
Sbjct: 171 SMALLDHPHIIRLFGIVLSTP--MMLVTELAPLGCLLTALRNNRQRFMVS-TLCDFMIQV 227
Query: 336 CCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIK 395
GM YLE +R +HRDLAARNVL+ + K+ DFG + K+P
Sbjct: 228 ASGMAYLESKRFIHRDLAARNVLLESNEKVKIGDFGLMRALSVEDDYYTMNP-KGKVPFA 286
Query: 396 WTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY--RMEAPE 453
W PEALKY KFS+ SD+WSFGI + E++S+G P+P + A+++ V+ R P
Sbjct: 287 WCPPEALKYRKFSHASDVWSFGICVIELFSYGEEPWPGLNGAQILAKVDMPLCERPLKPS 346
Query: 454 GCPPGPYELM-RAAWHADPASRPTFLHMRRNLADIRDH 490
CP Y L+ W DP++R F ++++L +R H
Sbjct: 347 HCPSLIYSLLVSLCWAHDPSNRAGFSELKKSLEQVRPH 384
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 155 bits (377), Expect = 2e-36
Identities = 102/287 (35%), Positives = 147/287 (51%), Gaps = 25/287 (8%)
Query: 221 DARWKIDERDLEI-RENIGKGEFGDVMLGILN--GTQ----KVAVKILKDREAASK---F 270
DA+W+ L+I + +G+G FG V GI N G + KVAVK+++D + S F
Sbjct: 540 DAKWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDF 599
Query: 271 RAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQI 329
E +M + +H N+++LLGL T G ++ E G+L D++R++ + Y I
Sbjct: 600 VKEMEIMKHIGRHPNVIQLLGLC-TQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKII 658
Query: 330 -NFAFDACC--------GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXX 380
NF C GM YL + VVHRDL+ARN+L+ K+ADFG
Sbjct: 659 GNFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYY 718
Query: 381 XXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVV 440
LP+KW APEAL K++ KSD+WS+GILLWEI++ G PY I +VV
Sbjct: 719 RKKTDGI----LPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVV 774
Query: 441 RHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADI 487
+ +G++ PE Y LM+ W +RP F + L DI
Sbjct: 775 DLIRKGFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIVEILIDI 821
>UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Ciona
intestinalis|Rep: Ephrin receptor like protein - Ciona
intestinalis (Transparent sea squirt)
Length = 1085
Score = 155 bits (376), Expect = 3e-36
Identities = 95/260 (36%), Positives = 131/260 (50%), Gaps = 16/260 (6%)
Query: 231 LEIRENIGKGEFGDVMLGILN-----GTQKVAVKILKDREAASK------FRAEASVMAS 279
+ I + IG GEFG+V G L G +KV +K A + F EA +
Sbjct: 716 VSINKVIGCGEFGEVYQGSLTLTDTGGKRKVIDVAIKQLHAQCQPNEQIDFLHEAKALER 775
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS-RG-RHYVTQLNQINFAFDACC 337
+H N+V+L +V S +VTE G L +LR RG + Y +
Sbjct: 776 FQHPNIVKLEAVVMASRP-FMIVTELMVNGCLGKFLRHHRGAKRYFKPTVLVRMLHGVAK 834
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM YL + VHRDLAARNVLI+ E KVADFG K+ ++WT
Sbjct: 835 GMAYLSKMCYVHRDLAARNVLINNELVCKVADFGLIRHIGEKKSTVNTKG--GKISLRWT 892
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ Y +S SD+WSFG+ WE+ ++G PY + +V++ + GYR+ APE CP
Sbjct: 893 APEAVAYQAYSQASDVWSFGVFAWEVITYGEKPYWSLTNQQVLQAINDGYRLPAPEDCPS 952
Query: 458 GPYELMRAAWHADPASRPTF 477
++LM WH D +RPTF
Sbjct: 953 VLHQLMLECWHRDKNTRPTF 972
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 155 bits (376), Expect = 3e-36
Identities = 96/295 (32%), Positives = 153/295 (51%), Gaps = 34/295 (11%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGIL------NGTQKVAVKILKDREAASKFR--- 271
D +W+ ++L + + +G+GEFG V+ G VAVK+LK+ + S+ R
Sbjct: 376 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 435
Query: 272 AEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR--GRHYV----- 323
+E +V+ + H ++++L G + G L+ E+ GSL +LR SR G Y+
Sbjct: 436 SEFNVLKQVNHPHVIKLYGAC-SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGS 494
Query: 324 --------------TQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVAD 369
T + I+FA+ GM+YL ++VHRDLAARN+L++ K++D
Sbjct: 495 RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD 554
Query: 370 FGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRV 429
FG Q ++P+KW A E+L + ++ +SD+WSFG+LLWEI + G
Sbjct: 555 FGLSRDVYEEDSYVKRS--QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGN 612
Query: 430 PYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
PYP IP + ++ G+RME P+ C Y LM W +P RP F + ++L
Sbjct: 613 PYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 667
>UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; Homo
sapiens|Rep: Tyrosine-protein kinase receptor - Homo
sapiens (Human)
Length = 1310
Score = 155 bits (375), Expect = 3e-36
Identities = 93/270 (34%), Positives = 137/270 (50%), Gaps = 20/270 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQ------KVAVKILKD---REAASKFRAEAS 275
++ +++ + +G G FG+V G ++G +VAVK L + + F EA
Sbjct: 800 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 859
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGR----HYVTQLNQIN 330
+++ H+N+VR +G+ S L+ E A G L +LR +R R + L+ ++
Sbjct: 860 IISKFNHQNIVRCIGVSLQSLPRFILL-ELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 918
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXX 387
A D CG +YLE +HRD+AARN L++ G AK+ DFG
Sbjct: 919 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGC 978
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
A LP+KW PEA F++K+D WSFG+LLWEI+S G +PYP EV+ V G
Sbjct: 979 --AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGG 1036
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
RM+ P+ CP Y +M W P RP F
Sbjct: 1037 RMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 1066
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 155 bits (375), Expect = 3e-36
Identities = 95/273 (34%), Positives = 141/273 (51%), Gaps = 27/273 (9%)
Query: 226 IDERDLEIRENIGKGEFGDVMLG-ILNGTQKVAVKILKDREAASK-----FRAEASVMAS 279
+D D++ ++ IG+G FG V+ I ++ I + +E ASK F E V+
Sbjct: 819 LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK 878
Query: 280 LKHE-NLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SR----------GRHYVTQLN 327
L H N++ LLG G L E+ G+LLD+LR SR + L+
Sbjct: 879 LGHHPNIINLLGAC-EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLS 937
Query: 328 Q---INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXX 384
++FA D GM+YL +++ +HRDLAARN+L+ AK+ADFG
Sbjct: 938 SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKT- 996
Query: 385 XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVE 444
+LP++W A E+L Y+ ++ SD+WS+G+LLWEI S G PY + AE+ +
Sbjct: 997 ----MGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052
Query: 445 RGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
+GYR+E P C Y+LMR W P RP+F
Sbjct: 1053 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSF 1085
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 155 bits (375), Expect = 3e-36
Identities = 98/283 (34%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDVMLGILN------GTQKVAVKILKD---REAASKFR 271
D W+I LE +G+G FG V G Q VAVK+LK+ + F
Sbjct: 464 DPAWEIKLEQLETDCLLGEGAFGRVFRATARDLPNHTGVQTVAVKMLKEDCCEQDLKDFI 523
Query: 272 AEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG---------RH 321
+E VM S+ KH N++ LL V + G +V E+C G+L +L+
Sbjct: 524 SEIEVMKSIGKHINILNLLA-VSSQQGKLYIVVEYCRHGNLRSFLKDNRPVMQANSVITK 582
Query: 322 YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXX 381
+T + +F GM +L ++ +HRD+AARNVL+ K+ADFG
Sbjct: 583 KITLYDLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLARDIHEQDY 642
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
+LP+KW A EAL ++ +SD+WSFGIL WEI +FG PYP I L ++
Sbjct: 643 YRKCT--DGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIALEKLFD 700
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+++GYRME P C Y LM W P+ RPTF + +L
Sbjct: 701 LLKQGYRMERPLNCTDDMYTLMLNCWKEIPSKRPTFSQLIEDL 743
>UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;
n=37; Euteleostomi|Rep: ALK tyrosine kinase receptor
precursor - Homo sapiens (Human)
Length = 1620
Score = 155 bits (375), Expect = 3e-36
Identities = 93/270 (34%), Positives = 137/270 (50%), Gaps = 20/270 (7%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILNGTQ------KVAVKILKD---REAASKFRAEAS 275
++ +++ + +G G FG+V G ++G +VAVK L + + F EA
Sbjct: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1169
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGR----HYVTQLNQIN 330
+++ H+N+VR +G+ S L+ E A G L +LR +R R + L+ ++
Sbjct: 1170 IISKFNHQNIVRCIGVSLQSLPRFILL-ELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 1228
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXX 387
A D CG +YLE +HRD+AARN L++ G AK+ DFG
Sbjct: 1229 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGC 1288
Query: 388 XQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGY 447
A LP+KW PEA F++K+D WSFG+LLWEI+S G +PYP EV+ V G
Sbjct: 1289 --AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGG 1346
Query: 448 RMEAPEGCPPGPYELMRAAWHADPASRPTF 477
RM+ P+ CP Y +M W P RP F
Sbjct: 1347 RMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 1376
>UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor
tyrosine kinase Torso-like protein; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to receptor tyrosine
kinase Torso-like protein - Nasonia vitripennis
Length = 590
Score = 154 bits (374), Expect = 5e-36
Identities = 71/156 (45%), Positives = 97/156 (62%), Gaps = 2/156 (1%)
Query: 329 INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX 388
+NFA GME+L R+VHRDLAARNVL+ A+ T K++DFG
Sbjct: 391 LNFARQVASGMEFLSSNRIVHRDLAARNVLVCADQTVKISDFGLSRDIYQENVYKKQT-- 448
Query: 389 QAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR 448
KLPIKW A EAL + ++ SD+WSFG+LL+EI + G PYP +P EV+ ++ GYR
Sbjct: 449 NGKLPIKWMAIEALTHQVYTTHSDVWSFGVLLYEIVTLGGNPYPGLPCCEVLHFLKSGYR 508
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
ME P C YE+MR+ WH +P +RPTF ++++ L
Sbjct: 509 MERPSNCGFQLYEIMRSCWHENPLNRPTFYNLKQQL 544
Score = 44.0 bits (99), Expect = 0.010
Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 9/103 (8%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKDREAAS---KFRAEAS 275
+++I L I++ +G G G V L L +K VAVK+L++ ++ F E +
Sbjct: 230 KFEIQVDRLSIKKILGSGISGVVKLATLQDDKKKIIQVAVKMLREDASSDDVQNFHREIA 289
Query: 276 VMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS 317
+M S H N+V ++G T S LV E C++G L YLR+
Sbjct: 290 LMKSAGNHPNIVSIIGCC-TLSKQPLLVVEFCSKGDLQTYLRT 331
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 154 bits (374), Expect = 5e-36
Identities = 95/256 (37%), Positives = 132/256 (51%), Gaps = 18/256 (7%)
Query: 237 IGKGEFGDVMLGIL----NGTQKVAVKILKDR---EAASKFRAEASVMASLKHENLVRLL 289
+G+G FG+V G+ N Q VAVK + + + F EA +M+ H N+V +
Sbjct: 894 LGQGAFGEVFQGVYRYRRNQEQPVAVKAIPSSSRPQTEADFMMEALIMSKFNHPNIVHFI 953
Query: 290 GLVFTSSGGTCLVTEHCAQGSLLDYLRS-RGR-HYVTQLNQ---INFAFDACCGMEYLER 344
G+ F + +V E A G+L ++LR R R T L I FD G +Y+E
Sbjct: 954 GVSFERNP-KYIVLELLAGGNLKNFLREERPRADRPTSLRMQDLIMCGFDVANGCKYMEE 1012
Query: 345 QRVVHRDLAARNVLISAEGTA---KVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
R +HRD+AARN L++++G K+ADFG +A LPIKW PE+
Sbjct: 1013 ARFIHRDIAARNCLLTSKGPGRIVKIADFGMAKDIYRSDYYRKGG--KAMLPIKWMPPES 1070
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYE 461
F+ K+D+W+FG+LLWEI SFG +PY E + V G R+E P GCP Y
Sbjct: 1071 FLDGIFTTKTDVWAFGVLLWEIMSFGYIPYTGCTNREAMTMVTLGGRLEKPAGCPDPIYG 1130
Query: 462 LMRAAWHADPASRPTF 477
LM WH P RP+F
Sbjct: 1131 LMTRCWHPRPEDRPSF 1146
>UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep:
Zgc:154019 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 732
Score = 154 bits (374), Expect = 5e-36
Identities = 93/262 (35%), Positives = 132/262 (50%), Gaps = 12/262 (4%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQ----KVAVKILKDREA--ASKFRAEASVMAS 279
I +R+L + +G G FG V + VAVK L+ + S F E + M S
Sbjct: 106 IQDRELLFGDRLGSGSFGVVRKAEWHTPTGRVLPVAVKTLRSGQVDLVSDFLQEVTSMQS 165
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGM 339
L H N++ L G+V T +VTE GSL D LR R Y + F+ GM
Sbjct: 166 LDHPNIIHLYGVVLTHP--LKMVTELAPLGSLYDTLRLRHGEYPLSRLWL-FSTQIAAGM 222
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
EYLE +R +HRDLAARNVL++A K+ DFG ++P W AP
Sbjct: 223 EYLESRRFIHRDLAARNVLLAAREQVKIGDFGLMRGLDDRDHYIMTA--HRRIPFAWCAP 280
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER-GYRMEAPEGCPPG 458
E+L+ FS+ SD+W FG+ LWE++++ P+ + +++ VER G R+E P CP
Sbjct: 281 ESLRTGSFSHASDVWMFGVTLWEMFTYCEEPWLGLSGRQILYRVEREGERLERPPDCPQE 340
Query: 459 PYELMRAAWHADPASRPTFLHM 480
Y +MR W + RPTF +
Sbjct: 341 LYAVMRKCWACNSTERPTFAQL 362
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 154 bits (374), Expect = 5e-36
Identities = 102/293 (34%), Positives = 147/293 (50%), Gaps = 28/293 (9%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILK----DREAAS 268
+V W++ + +G+G FG V GI K A+K + DRE
Sbjct: 1070 YVPDEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHATDRERI- 1128
Query: 269 KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQL-- 326
+F EASVM + ++VRLLG+V + T +V E +G L YLRS L
Sbjct: 1129 EFLNEASVMKAFDTFHVVRLLGVV-SRGQPTLVVMELMERGDLKTYLRSMRPDAEGSLPS 1187
Query: 327 ---------NQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
N + A + GM YL ++ VHRDLAARN +++ + T KV DFG
Sbjct: 1188 SPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMTRDIY 1247
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
+ +P++W +PE+LK FS+ SD WS+G++LWE+ + PY +
Sbjct: 1248 ETDYYRKGT--KGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGLSNE 1305
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDH 490
+V+R+V G ME PE CP YELMRA W P++RPTFL + +AD+ H
Sbjct: 1306 QVLRYVVEGGVMERPEQCPDRLYELMRACWTHRPSARPTFLQL---VADLVPH 1355
>UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 419
Score = 154 bits (374), Expect = 5e-36
Identities = 95/277 (34%), Positives = 147/277 (53%), Gaps = 15/277 (5%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGIL--NGTQK-VAVKILKDREAASKFRA-------E 273
W++ +++ + +G+G FG V G ++ VAVK+ K E S RA E
Sbjct: 131 WELRHDQIKLGKMLGEGAFGGVYKAAFYCKGEKRMVAVKVNKGNEKIST-RAMIEDVCKE 189
Query: 274 ASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAF 333
A +M +H N+V G V LV E +QG+L +L++ ++ V+ +++ ++F
Sbjct: 190 ARIMRQYQHPNVVCFFG-VCVEKEPIMLVMELASQGALDSFLKNE-KNNVSLRDKLKYSF 247
Query: 334 DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLP 393
DA G+EYL + +HRD+AARN L+ + K+ DFG QAKLP
Sbjct: 248 DASKGLEYLHQHGCIHRDVAARNFLMH-KNVVKITDFGLSKQLSDLAHKYKLKDIQAKLP 306
Query: 394 IKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPE 453
I+W APE + ++ KSD++SFGILLWEI+ G +PYP + LAEV + V+ GYRM+AP+
Sbjct: 307 IRWLAPEVIVTATYTFKSDVYSFGILLWEIFMDGAIPYPGMKLAEVKQKVKNGYRMDAPD 366
Query: 454 GCPPGPYELM-RAAWHADPASRPTFLHMRRNLADIRD 489
P +M W +P R +R + + D
Sbjct: 367 RMPAFVRNIMISQCWPQNPEDRGNMNEIRLAMESVLD 403
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 154 bits (374), Expect = 5e-36
Identities = 92/271 (33%), Positives = 139/271 (51%), Gaps = 19/271 (7%)
Query: 223 RWKIDERDLEIRENIGKGEFGDVMLGILNGTQ-----KVAVKILKDR---EAASKFRAEA 274
R ++D+ + +G G FG+V G++ G +VA+K LK +F EA
Sbjct: 443 RIRLDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEA 502
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR---GRHY-VTQLNQIN 330
+M++ KH+++ RLLG V + ++ E G LL YL ++ G+ +T L+ I+
Sbjct: 503 QLMSNFKHKHITRLLG-VCLEADALLIIMELMQGGDLLSYLPAQPLPGQAARLTMLDLIS 561
Query: 331 FAFDACCGMEYLERQRVVHRDLAARNVLISA----EGTAKVADFGXXXXXXXXXXXXXXX 386
D G YLE VHRDLA RN L+S+ + K+ DFG
Sbjct: 562 MCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEG 621
Query: 387 XXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG 446
+ LP++W +PE+L F+++SD+W+FG+LLWEI + G PY EV+ HV G
Sbjct: 622 --EGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREG 679
Query: 447 YRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
++ P+ CP YELM+ W P RPTF
Sbjct: 680 GHLDRPKVCPNEMYELMKYCWKFSPEERPTF 710
>UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=53; Euteleostomi|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Homo sapiens (Human)
Length = 869
Score = 154 bits (374), Expect = 5e-36
Identities = 96/286 (33%), Positives = 142/286 (49%), Gaps = 34/286 (11%)
Query: 230 DLEIRENIGKGEFGDVMLGILNGT------QKVAVKILKDREAA---SKFRAEASVMASL 280
++E +IG+G FG V G VAVK+LK+ +A + F+ EA++MA
Sbjct: 574 NIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF 633
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLN------------- 327
+ N+V+LLG+ CL+ E+ A G L ++LRS H V L+
Sbjct: 634 DNPNIVKLLGVCAVGKP-MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSP 692
Query: 328 ---------QINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXX 378
Q+ A GM YL ++ VHRDLA RN L+ K+ADFG
Sbjct: 693 GPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYS 752
Query: 379 XXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAE 438
+PI+W PE++ YN+++ +SD+W++G++LWEI+S+G PY + E
Sbjct: 753 ADYYKANENDA--IPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEE 810
Query: 439 VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
V+ +V G + PE CP Y LMR W PA RP+F + R L
Sbjct: 811 VIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL 856
>UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3
precursor; n=41; cellular organisms|Rep: Receptor
tyrosine-protein kinase erbB-3 precursor - Homo sapiens
(Human)
Length = 1342
Score = 154 bits (374), Expect = 5e-36
Identities = 97/276 (35%), Positives = 142/276 (51%), Gaps = 13/276 (4%)
Query: 228 ERDLEIRENIGKGEFGDVMLGIL--NGTQ---KVAVKILKDREAASKFRAEASVM---AS 279
E +L + +G G FG V G+ G V +K+++D+ F+A M S
Sbjct: 706 ETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGS 765
Query: 280 LKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGM 339
L H ++VRLLGL SS LVT++ GSLLD++R QL +N+ GM
Sbjct: 766 LDHAHIVRLLGLCPGSS--LQLVTQYLPLGSLLDHVRQHRGALGPQL-LLNWGVQIAKGM 822
Query: 340 EYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAP 399
YLE +VHR+LAARNVL+ + +VADFG +AK PIKW A
Sbjct: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYS--EAKTPIKWMAL 880
Query: 400 EALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGP 459
E++ + K++++SD+WS+G+ +WE+ +FG PY + LAEV +E+G R+ P+ C
Sbjct: 881 ESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDV 940
Query: 460 YELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQL 495
Y +M W D RPTF + + P L
Sbjct: 941 YMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 976
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 154 bits (373), Expect = 6e-36
Identities = 96/272 (35%), Positives = 140/272 (51%), Gaps = 19/272 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL----NGTQKVAVKILK-DREAASKFR---AEASVM 277
I ER L + +GKGEFG V L N QKVAVK+LK D ++S EA+ M
Sbjct: 492 IFERLLTLGRMLGKGEFGSVREAFLKSENNSGQKVAVKVLKTDINSSSDIEQCLKEAAYM 551
Query: 278 ASLKHENLVRLLGLVFTSSGGTCL-----VTEHCAQGSLLDY-LRSR-GRHYVTQLNQ-- 328
H N+++L+G+ L + G L + L SR G T Q
Sbjct: 552 KDFHHPNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSRLGDEPFTVSQQIL 611
Query: 329 INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXX 388
I F D GMEYL + ++HRDLAARN +++ + VADFG
Sbjct: 612 IQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSV- 670
Query: 389 QAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR 448
+KLP+KW A E+L N ++ +SD+W+FG+ +WEI + G+ PYP + +E+ ++ +G R
Sbjct: 671 -SKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIYEYLIKGER 729
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTFLHM 480
++ P CP YE+M + W P RP+F H+
Sbjct: 730 LKQPPDCPADIYEIMHSCWSPVPKCRPSFQHL 761
>UniRef50_O76411 Cluster: Suppressor of constitutive dauer formation
protein 2; n=2; Caenorhabditis|Rep: Suppressor of
constitutive dauer formation protein 2 - Caenorhabditis
elegans
Length = 1446
Score = 154 bits (373), Expect = 6e-36
Identities = 102/294 (34%), Positives = 147/294 (50%), Gaps = 20/294 (6%)
Query: 212 GTLQSQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILKDREAASK-- 269
G ++ +D+ I +E +G+G FG+V G +G K+AVK++ +AS+
Sbjct: 982 GRTTRKAALDSLPSISRDSIERGRVLGRGNFGEVYYGEYSGV-KLAVKMISRTFSASQAS 1040
Query: 270 ---FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQL 326
F EA M + EN+VRL+G+ F + E+ G LL +++ + V+ L
Sbjct: 1041 QSDFCNEALCMGTFVDENVVRLIGIDFEKVP-YMIALEYMEGGDLLSFVKECRPNQVS-L 1098
Query: 327 NQINFAFD----ACC----GMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXX 375
N A CC G + LE VHRD+AARN+L++ G AK+ADFG
Sbjct: 1099 NPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAKE 1158
Query: 376 XXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIP 435
+ +PIKWT PEA F+ KSD+WSFG+L WE++S G VPYP
Sbjct: 1159 ITYGTEYYRING-RTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRR 1217
Query: 436 LAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
EV+ + G R+E P G P Y+LMR W A RP F+ + DI+D
Sbjct: 1218 NEEVMLMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQD 1271
>UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 154 bits (373), Expect = 6e-36
Identities = 86/225 (38%), Positives = 125/225 (55%), Gaps = 15/225 (6%)
Query: 255 KVAVKILKDR---EAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
+VAVK+L+D E KF EA++M H N+V + G+V T+S +V EH + G+L
Sbjct: 2 QVAVKMLRDSSDSEDRVKFLQEAAIMRQFTHRNVVYMYGVV-TNSNPIMIVLEHMSLGNL 60
Query: 312 LDYLRSR----GRHYV----TQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEG 363
+YL + G+ V T+ + D GM+YL VHRDLAARN+L+ ++
Sbjct: 61 RNYLLNLRLKYGKEVVLCLDTRSQLLGMIRDIAAGMQYLHSLGFVHRDLAARNILLDSDM 120
Query: 364 TAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEI 423
K+ DFG ++P+KWTAPEA+ Y ++S+ SD+WS+G+LL+EI
Sbjct: 121 ICKIGDFGMSRDLMICDYYTSRG---GRIPVKWTAPEAINYGRYSSASDVWSYGVLLFEI 177
Query: 424 YSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWH 468
+S G PY + EVV V RGYR+ P+ CP Y LM W+
Sbjct: 178 WSLGDKPYANLDNNEVVEAVSRGYRLPPPDHCPTMIYRLMVDCWY 222
>UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=18; Gnathostomata|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Gallus gallus (Chicken)
Length = 947
Score = 154 bits (373), Expect = 6e-36
Identities = 97/297 (32%), Positives = 145/297 (48%), Gaps = 32/297 (10%)
Query: 230 DLEIRENIGKGEFGDVMLGILNGT------QKVAVKILKDREAA---SKFRAEASVMASL 280
++E +IG+G FG V G VAVK+LK+ +A + F+ EA++MA
Sbjct: 654 NIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF 713
Query: 281 KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDAC---- 336
+ N+V+LLG+ CL+ E+ A G L +YLR R + L Q AC
Sbjct: 714 DNPNIVKLLGVCAVGKP-MCLLFEYMAYGDLNEYLRDRSPRNLCSLVQGGLEARACLLNP 772
Query: 337 ----------------CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXX 380
GM YL ++ VHRDLA RN L+ K+ADFG
Sbjct: 773 LALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSAD 832
Query: 381 XXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVV 440
+PI+W PE++ YN+++ +SD+W++G++LWEI+S+G PY + EV+
Sbjct: 833 YYKANENDA--IPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVI 890
Query: 441 RHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQL 497
+V G + P+ CP Y LMR W PA RP+F + R L + + A Q+
Sbjct: 891 YYVRDGNILSCPDNCPLELYNLMRLCWSKLPADRPSFASIHRILERMYERAVASPQV 947
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 153 bits (372), Expect = 8e-36
Identities = 100/287 (34%), Positives = 145/287 (50%), Gaps = 22/287 (7%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILK----DRE 265
S ++ W++ + + + + +G G FG V GI K AVK + DRE
Sbjct: 1114 STVYIPDEWEVPRKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRE 1173
Query: 266 AASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRG----RH 321
+F EASVM ++VRLLG+V + T +V E G L YLRS +
Sbjct: 1174 RV-EFLNEASVMKGFNTHHVVRLLGVV-SQGQPTLVVMELMVNGDLKTYLRSHRPDVCEN 1231
Query: 322 YVTQ---LNQI-NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXX 377
+ Q LN+I A + GM YL ++ VHRDLAARN ++S + T K+ DFG
Sbjct: 1232 FSRQPPTLNRIMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMTRDVY 1291
Query: 378 XXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 437
+ LP++W APE+LK F++ SD+WS+G++LWE+ + PY +
Sbjct: 1292 ETDYYRKGT--KGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGLSND 1349
Query: 438 EVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+V+R+V G ME PE CP Y +MR W RPTF+ + R L
Sbjct: 1350 QVLRYVIDGGVMERPENCPDILYGMMRQTWCHKATRRPTFIDIEREL 1396
>UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 472
Score = 153 bits (372), Expect = 8e-36
Identities = 92/250 (36%), Positives = 131/250 (52%), Gaps = 13/250 (5%)
Query: 237 IGKGEFGDVMLGILN----GTQKVAVKILKDREAASKFRA----EASVMASLKHENLVRL 288
IG G+FG+V L+ G VAVK K ++++ K RA E +VM++L H N+VR
Sbjct: 213 IGHGQFGEVFRATLHKGTPGEVLVAVKTTK-KDSSEKDRADFMKEMAVMSTLLHPNIVRF 271
Query: 289 LGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVV 348
G+V + +V E+ G L YL ++ H QL + + D GM Y+ + +V
Sbjct: 272 YGVVHKAVDSDLIVLEYLPFGDLKSYL-TKTTHSRKQL--VKYMIDVATGMHYISEKGLV 328
Query: 349 HRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFS 408
HRDLAARNVL+ KVADFG PIKW PE++ KFS
Sbjct: 329 HRDLAARNVLVGENEVCKVADFGLLRELPEDGDIYFSMH-NIPCPIKWMPPESIDGGKFS 387
Query: 409 NKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWH 468
SD+WSFG+L+WE+++ + PY + E V +GYR+ P G P ++M + WH
Sbjct: 388 VASDVWSFGVLMWEMFNPSKPPYQGMSNMECAVAVCKGYRLPLPRGIPSILAKVMESCWH 447
Query: 469 ADPASRPTFL 478
+P RP FL
Sbjct: 448 QNPHKRPGFL 457
>UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5;
Caenorhabditis|Rep: Receptor tyrosine kinase -
Caenorhabditis elegans
Length = 928
Score = 153 bits (371), Expect = 1e-35
Identities = 94/287 (32%), Positives = 140/287 (48%), Gaps = 20/287 (6%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGI----LNGTQKVAVKILKDREAAS-----KFRAEA 274
++I L +RE IG+G+FG V GI L + +AV + K R A+ + E
Sbjct: 583 FEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEI 642
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR---GRHYVTQLNQINF 331
+A+ H N+++L+G+ + + V E+ G L + L+ R H + + + N
Sbjct: 643 RAVATFDHPNVIKLIGVCYMDNS-LLAVFEYMVHGDLHELLKVRVPPADHDMGGITEANA 701
Query: 332 AF-----DACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXX 386
F GMEYL VHRDLA RN L+ T K+ADFG
Sbjct: 702 EFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLH 761
Query: 387 XXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG 446
++ +P++W + EA++ +FS SD+WSFG+ LWEI+SFGR PY +V+ V
Sbjct: 762 --RSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANR 819
Query: 447 YRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPA 493
+ +E P CP Y LM WH + RPTF +R L +PA
Sbjct: 820 HLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSWSLASPA 866
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 153 bits (371), Expect = 1e-35
Identities = 98/291 (33%), Positives = 143/291 (49%), Gaps = 30/291 (10%)
Query: 221 DARWKIDERDLEIRENIGKGEFGDV----MLGI--LNGTQKVAVKILK---DREAASKFR 271
D W++ ++L + + +G G FG V +GI G VAVK LK + + F
Sbjct: 18 DEAWEVPPQNLSVIKRLGSGNFGHVDKAMAIGIPGFPGQVTVAVKTLKATAQEKDKTDFL 77
Query: 272 AEASVMASLK-HENLVRLLGLVFTSSGGT----CLVTEHCAQGSLLDYLR-SRGRH---- 321
E ++M SL+ H ++VRL+G +G ++ E+ G LL YLR SRG
Sbjct: 78 TELNLMKSLRPHPHVVRLIGCCTRQAGELSNHLAIIFEYLPYGDLLGYLRRSRGHEDWYC 137
Query: 322 --------YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXX 373
+ + + FA+ GM +L + VHRDLAARNVL+ T K++D G
Sbjct: 138 SGDLRPPSRLVSKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDLGLA 197
Query: 374 XXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPR 433
A+LP+KW PE+L Y + S+ SD+WS+GI+LWEI++ G PYP
Sbjct: 198 RDVSQDIYTRTSS---ARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYPG 254
Query: 434 IPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNL 484
+ + R + GYRM P Y +M W DP RPTF + N+
Sbjct: 255 VKSKGIPRMLREGYRMPKPPHVGDALYFVMLRCWQEDPDERPTFDELCDNM 305
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 153 bits (370), Expect = 1e-35
Identities = 100/298 (33%), Positives = 148/298 (49%), Gaps = 25/298 (8%)
Query: 213 TLQSQSFVDARWKIDERDLEIRENIGKGEFGDV-------MLGILNGTQKVAVKILK--- 262
TL +Q ++ L +R +G G FG+V +LG+ +G KVAVK LK
Sbjct: 1927 TLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGS 1986
Query: 263 -DREAASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR--G 319
D+E +F EA +M+ H N+++ LG+ + ++ E G LL YLR
Sbjct: 1987 TDQEKI-EFLKEAHLMSKFNHPNILKQLGVCLLNEP-QYIILELMEGGDLLTYLRKARMA 2044
Query: 320 RHY---VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEG-----TAKVADFG 371
Y +T ++ ++ D G YLER +HRDLAARN L+S + K+ DFG
Sbjct: 2045 TFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFG 2104
Query: 372 XXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPY 431
+ LP++W APE+L F+ +SD+WSFGIL+WEI + G PY
Sbjct: 2105 LARDIYKNDYYRKRG--EGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPY 2162
Query: 432 PRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
P +V+ +V+ G R+E P CP + LM W +P RPTF ++ L R+
Sbjct: 2163 PAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 2220
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14; Eutheria|Rep:
Insulin receptor-related protein precursor (EC 2.7.10.1)
(IRR) (IR- related receptor) [Contains: Insulin
receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 153 bits (370), Expect = 1e-35
Identities = 103/314 (32%), Positives = 152/314 (48%), Gaps = 25/314 (7%)
Query: 216 SQSFVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILKDREAASK 269
S +V W++ + I +G+G FG V G+ G + VA+K + + + +
Sbjct: 964 SDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRE 1023
Query: 270 ---FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-------- 318
F EASVM + K ++VRLLG+V + T ++ E +G L +LRS
Sbjct: 1024 CIEFLKEASVMKAFKCHHVVRLLGVV-SQGQPTLVIMELMTRGDLKSHLRSLRPEAENNP 1082
Query: 319 GRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXX 378
G I A + GM YL + VHRDLAARN ++S + T K+ DFG
Sbjct: 1083 GLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE 1142
Query: 379 XXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAE 438
+ LP++W APE+LK F+ SD+WSFG++LWEI + PY + +
Sbjct: 1143 TDYYRKGG--KGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ 1200
Query: 439 VVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQLW 498
V++ V G +E EGCP ELM W +P RP+F H+ L I++ +L
Sbjct: 1201 VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI---LDSIQEELRPSFRL- 1256
Query: 499 ELSLVVSYDLEGAR 512
LS S + GAR
Sbjct: 1257 -LSFYYSPECRGAR 1269
>UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=10;
Eutheria|Rep: Ephrin type-A receptor 10 precursor - Homo
sapiens (Human)
Length = 1008
Score = 153 bits (370), Expect = 1e-35
Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 15/282 (5%)
Query: 225 KIDERDLEIRENIGKGEFGDVMLGILN--GTQK--VAVKILKDREAASK---FRAEASVM 277
++D + + + ++G G FG++ G L G Q+ VAV +L+D + S+ F AEA +
Sbjct: 639 ELDAKSVTLERSLGGGRFGELCCGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAEALTL 698
Query: 278 ASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSR-GRHYVTQLNQINFAFDAC 336
H ++VRL G+V T +VTE+ + G+L +LR G+ QL +
Sbjct: 699 GQFDHSHIVRLEGVV-TRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQL--MGLLPGLA 755
Query: 337 CGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKW 396
M+YL VHR LAAR+VL+S++ K++ FG + P W
Sbjct: 756 SAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTMS---GRSPALW 812
Query: 397 TAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCP 456
APE L++ FS+ SD+WSFGI++WE+ +FG PY + +V++ VE G+R+ P CP
Sbjct: 813 AAPETLQFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCP 872
Query: 457 PGPYELMRAAWHADPASRPTFLHMRRNLAD-IRDHTPAQLQL 497
+ LM W DP RP F + L+ ++D P + L
Sbjct: 873 NLLHRLMLDCWQKDPGERPRFSQIHSILSKMVQDPEPPKCAL 914
>UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch
CG1594-PA; n=1; Apis mellifera|Rep: PREDICTED: similar to
hopscotch CG1594-PA - Apis mellifera
Length = 1133
Score = 152 bits (369), Expect = 2e-35
Identities = 97/283 (34%), Positives = 147/283 (51%), Gaps = 35/283 (12%)
Query: 233 IRENIGKGEFGDVMLGIL---NGT----QKVAVKILKDREAA----SKFRAEASVMASLK 281
++ IG+G +G+V G L NG Q+VA+K LK + A + F E ++M +L
Sbjct: 854 LQGKIGQGFYGEVYRGTLERENGKDIEPQQVAIKKLKKKRALETDINDFEREITIMKTLN 913
Query: 282 HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEY 341
H N+V++LG++ S CLV E+ GSL YL + +T + FA D GM+Y
Sbjct: 914 HPNVVKILGVI--SEPEVCLVMEYVKHGSLQSYLAIH-KQELTHRRLLGFALDIATGMDY 970
Query: 342 LERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA 401
L + +VHRDLAARN+L++ E K++DFG LPIKW APE+
Sbjct: 971 LGSEGIVHRDLAARNILVADENKVKISDFGLAQVIGENDYYILQT--DRSLPIKWYAPES 1028
Query: 402 LKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIP----------------LAEVVRHVER 445
++ KFS +SD+WSFG+ ++E +SFG PR+P E++ +E
Sbjct: 1029 IRDGKFSIRSDVWSFGVTMYETFSFGE--EPRLPGLDSSTERLQNEQEKGSTELLAALEN 1086
Query: 446 GYRMEAPEGCPPGPY-ELMRAAWHADPASRPTFLHMRRNLADI 487
G R+ P CP Y +LM W+ RP F + +++ D+
Sbjct: 1087 GIRLPCPFTCPQAIYVKLMHPCWNLKSHKRPDFATLCKDIEDL 1129
Score = 82.6 bits (195), Expect = 2e-14
Identities = 67/230 (29%), Positives = 100/230 (43%), Gaps = 26/230 (11%)
Query: 255 KVAVKILKDREAAS---KFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSL 311
+VA+KILK E A+ +F A + L+ LVRL GL T S G L E GSL
Sbjct: 464 EVALKILKQEEEANYTKEFLELAGKWSQLRSGTLVRLYGLTVTPSIGMLL--ELVRHGSL 521
Query: 312 LDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGT----AKV 367
+YLRS + ++ + + +LE VVH ++ +L+ A K+
Sbjct: 522 DEYLRSSSSQTIKTVDMVEATACLAAALWHLEENGVVHGNIRCNKLLVHAHTNNSFVVKL 581
Query: 368 ADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEA---LKYNKFSNKSDMWSFGILLWEIY 424
AD G ++ I W PE L+ + S ++D+W+ G +W+I+
Sbjct: 582 ADPGIFVYT--------------EMDIHWLPPETYNDLELARHSFQADIWAVGTTIWQIF 627
Query: 425 SFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASR 474
+ G + V +H E G R+ P GCP Y LM W SR
Sbjct: 628 ARGDTLQEFSNVTIVKKHYEAGKRLPIPNGCPTEVYRLMLECWGDSNGSR 677
>UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whole
genome shotgun sequence; n=8; Euteleostomi|Rep:
Chromosome undetermined SCAF15024, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 511
Score = 152 bits (369), Expect = 2e-35
Identities = 72/159 (45%), Positives = 95/159 (59%), Gaps = 3/159 (1%)
Query: 338 GMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWT 397
GM Y+ER+ +HRDL A NVL+S K+ADFG AK PIKWT
Sbjct: 353 GMAYIERRNYIHRDLRAANVLVSECLLCKIADFGLARVIEDDEYSAREG---AKFPIKWT 409
Query: 398 APEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPP 457
APEA+ Y F+ KSDMWSFG+LL+EI ++G++PYP + EV+ ++RGYRM P+ CP
Sbjct: 410 APEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMTKGEVISSIQRGYRMPQPDSCPS 469
Query: 458 GPYELMRAAWHADPASRPTFLHMRRNLADIRDHTPAQLQ 496
Y +M W P +RPTF +M+ L D T +Q Q
Sbjct: 470 ELYHMMLDCWKDKPDARPTFEYMQSVLNDFYTATESQYQ 508
Score = 69.3 bits (162), Expect = 2e-10
Identities = 36/95 (37%), Positives = 57/95 (60%), Gaps = 2/95 (2%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNGTQKVAVKILK-DREAASKFRAEASVMASLKH 282
W+I + + + + +G G+FG+V + N +VAVK LK F EA++M L+H
Sbjct: 202 WEISKDSIRMVKRLGAGQFGEVWMAYYNNITRVAVKTLKPGTMTVEAFMDEANLMKKLQH 261
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRS 317
+ LVRL +V T + ++TE+ A GSLLD+L+S
Sbjct: 262 DRLVRLYAVV-TKTEPIYIITEYMANGSLLDFLKS 295
>UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase receptor;
n=5; Endopterygota|Rep: Muscle-specific tyrosine kinase
receptor - Aedes aegypti (Yellowfever mosquito)
Length = 666
Score = 152 bits (369), Expect = 2e-35
Identities = 96/274 (35%), Positives = 141/274 (51%), Gaps = 23/274 (8%)
Query: 235 ENIGKGEFGDVML----GILNGTQ--KVAVKILKDREAAS---KFRAEASVMASLKHENL 285
+++G+G FG V G++ G VAVK+LKD + F EA ++A H N+
Sbjct: 387 KDLGQGAFGRVFQAKAPGLIAGEDFTLVAVKMLKDEASQDLQVDFEREACLLAEFDHPNI 446
Query: 286 VRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR--------SRGRHYVTQLNQ---INFAFD 334
V+LLG V CL+ E A+G L ++LR +R + T+L+ ++ A
Sbjct: 447 VKLLG-VCAIGRPMCLLFEFMARGDLNEFLRQCSPFAQQNRADNITTELSHGDLLSIASQ 505
Query: 335 ACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPI 394
GM YL ++ VHRDLA RN LI K+ADFG +PI
Sbjct: 506 IASGMVYLSERKFVHRDLATRNCLIDDNMVVKIADFGLSHKIYLQDYYKGDENDA--IPI 563
Query: 395 KWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEG 454
+W E++ YNK++ +SD+W++G+ LWEI+SF PY + EVV+ V+ G + PE
Sbjct: 564 RWMPLESILYNKYTIESDVWAYGVCLWEIFSFAMQPYYGMTHEEVVKFVKEGNMLSCPEN 623
Query: 455 CPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
P Y+LMR W PA RP+F + + L IR
Sbjct: 624 TPLTVYDLMRKCWSRKPADRPSFPIIFQKLQQIR 657
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 152 bits (369), Expect = 2e-35
Identities = 93/279 (33%), Positives = 136/279 (48%), Gaps = 20/279 (7%)
Query: 219 FVDARWKIDERDLEIRENIGKGEFGDVMLGILNGTQK----VAVKILKDREAAS-----K 269
+V W++ + + +G+G FG V G+ G K V I EAAS +
Sbjct: 987 YVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE 1046
Query: 270 FRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQ---- 325
F EASVM ++VRLLG+V + T ++ E +G L YLRS
Sbjct: 1047 FLNEASVMKEFNCHHVVRLLGVV-SQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA 1105
Query: 326 ----LNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXX 381
I A + GM YL + VHRDLAARN +++ + T K+ DFG
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165
Query: 382 XXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
+ LP++W +PE+LK F+ SD+WSFG++LWEI + PY + +V+R
Sbjct: 1166 YRKGG--KGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLR 1223
Query: 442 HVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHM 480
V G ++ P+ CP +ELMR W +P RP+FL +
Sbjct: 1224 FVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming
protein erbB; n=8; root|Rep: Tyrosine-protein kinase
transforming protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 152 bits (369), Expect = 2e-35
Identities = 94/267 (35%), Positives = 139/267 (52%), Gaps = 13/267 (4%)
Query: 237 IGKGEFGDVMLG--ILNGTQ-KVAVKILKDREAAS-----KFRAEASVMASLKHENLVRL 288
+G G FG V G I G + K+ V I + REA S + EA VMAS+ + ++ RL
Sbjct: 138 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 197
Query: 289 LGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVV 348
LG+ TS+ L+T+ G LLDY+R + +Q +N+ GM YLE +R+V
Sbjct: 198 LGICLTST--VQLITQLMPYGCLLDYIREHKDNIGSQY-LLNWCVQIAKGMNYLEERRLV 254
Query: 349 HRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFS 408
HRDLAARNVL+ K+ DFG K+PIKW A E++ + ++
Sbjct: 255 HRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEG--GKVPIKWMALESILHRIYT 312
Query: 409 NKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWH 468
++SD+WS+G+ +WE+ +FG PY IP +E+ +E+G R+ P C Y +M W
Sbjct: 313 HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWM 372
Query: 469 ADPASRPTFLHMRRNLADIRDHTPAQL 495
D SRP F + + + P L
Sbjct: 373 IDADSRPKFRELIAEFSKMARDPPRYL 399
>UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 948
Score = 152 bits (368), Expect = 2e-35
Identities = 90/277 (32%), Positives = 140/277 (50%), Gaps = 28/277 (10%)
Query: 225 KIDERDLEIRENIGKGEFGDVM----LGILNGTQK--VAVKILKDR---EAASKFRAEAS 275
++D + ++G+G FG V+ LG++ G + VAVKILK+ + +F EA+
Sbjct: 611 EVDRDKVRYEGDLGQGHFGLVVKATALGVVPGRDQCIVAVKILKEGASLQTKKEFFHEAA 670
Query: 276 VMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHY------------- 322
+M S H N+V+L+G V C++ E G L ++LR +
Sbjct: 671 LMHSFDHPNIVKLIG-VCVEQEPLCMIFEFMQLGDLNNFLRHNSPKWQESSASCAKYGGP 729
Query: 323 ---VTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXX 379
+T Q+ + D G+ YL +HRDLA RN L+S + K++DFG
Sbjct: 730 KCDITTPIQVAMSLDITAGLAYLADNHYIHRDLATRNCLVSGDLRIKISDFGLSQDIYST 789
Query: 380 XXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEV 439
LPI+W PEA+ + +F+ +SD+WS G++LWE++S+G PY + +V
Sbjct: 790 DYCRLSQSEL--LPIRWMPPEAILFARFTTQSDVWSLGVVLWELFSYGIQPYYSMSNEQV 847
Query: 440 VRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPT 476
+ HV G M P+GCP Y+LM W+ DP RPT
Sbjct: 848 IAHVRDGNVMNCPDGCPSEIYDLMVDCWNMDPGQRPT 884
>UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus
multilocularis|Rep: EGF receptor - Echinococcus
multilocularis
Length = 1564
Score = 152 bits (368), Expect = 2e-35
Identities = 77/210 (36%), Positives = 118/210 (56%), Gaps = 3/210 (1%)
Query: 273 EASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFA 332
EA VMAS++H+N + L+G+ T C+V+ +GSL YLR R + +++A
Sbjct: 1065 EAKVMASVQHKNCLPLIGVCLTRKM-QCMVSMFVEEGSLDRYLRLH-RDDLNSFTLLSWA 1122
Query: 333 FDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKL 392
GM YLE + ++HRDLAARNVL+ + ++ DFG ++
Sbjct: 1123 EQIADGMAYLEERGIIHRDLAARNVLVQSRELVQITDFGLAKMLDTNNEDSVVVRT-GRV 1181
Query: 393 PIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRMEAP 452
PI+W A E L+ +S+K+D+WS+G+ LWEI++FG+ PY I +E+ HV +G R+ P
Sbjct: 1182 PIRWLAIETLQAGIYSHKTDVWSYGVTLWEIFTFGKQPYENISTSEIKDHVMKGVRLSQP 1241
Query: 453 EGCPPGPYELMRAAWHADPASRPTFLHMRR 482
E C Y +M W + SRPTFL + +
Sbjct: 1242 EICTLDTYMVMVQCWMEEHESRPTFLELMK 1271
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 151 bits (367), Expect = 3e-35
Identities = 98/283 (34%), Positives = 141/283 (49%), Gaps = 24/283 (8%)
Query: 228 ERDLEIRENIGKGEFGDVMLGIL------NGTQKVAVKILKD---REAASKFRAEASVMA 278
E L + E++G+G FG V G + + T +VA+K LKD +E F E+ +M
Sbjct: 266 EDQLILTESLGEGAFGRVYKGSMKTGDDDDRTVEVAIKTLKDISQQENIDNFVQESILML 325
Query: 279 SLKHENLVRLLGLVF-TSSGGTCLVTEHCAQGSLLDYLRSRG--------RHYVTQLNQ- 328
H N++ LLG+ F T+ +V A G L YL S+ H+ L++
Sbjct: 326 GFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSYLMSKRDPSVTTKFTHFPQGLDEE 385
Query: 329 --INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXX 386
+ + GMEYL VHRDLAARN ++S E T +VADFG
Sbjct: 386 RALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSGELTVRVADFGLSRDVYSKDYYRMGT 445
Query: 387 XXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERG 446
+ LP+KW APE+L N F+ KSD+WSFG++ WE++S PYP I E+ ++ G
Sbjct: 446 --KTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEVFSL-VAPYPGIGNHEMSDYIGGG 502
Query: 447 YRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRD 489
R++ P CP YELM W+ + RP F + L + D
Sbjct: 503 RRLKIPRLCPREIYELMEQCWNEESNKRPNFSELVSQLERVID 545
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 151 bits (367), Expect = 3e-35
Identities = 87/229 (37%), Positives = 119/229 (51%), Gaps = 15/229 (6%)
Query: 265 EAASKFRAEASVMASL-KHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGRH- 321
E +F E S+M L H+N+V L T LV E +G LLDYLR +R +
Sbjct: 9 EQGEEFLKEISLMKKLGSHKNIVNFL-CCSTVKEPFMLVVEFLPKGDLLDYLRRNRSKQN 67
Query: 322 ---------YVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGX 372
+T + ++F++ GMEYL ++ VHRDLAARNVL++ KVADFG
Sbjct: 68 DETGEQEDEMITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGL 127
Query: 373 XXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYP 432
KLPIKW +PEA+ F+ +SD+WS+G++LWEI + G PYP
Sbjct: 128 TRDLYEESAYQGHS--NRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYP 185
Query: 433 RIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHMR 481
I +V + GYRME P+ C Y +M+ W P RPTF +R
Sbjct: 186 TISTRDVFVMLRSGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTFSDLR 234
>UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3;
Caenorhabditis|Rep: Ephrin receptor 1 precursor -
Caenorhabditis elegans
Length = 1122
Score = 151 bits (367), Expect = 3e-35
Identities = 87/239 (36%), Positives = 126/239 (52%), Gaps = 13/239 (5%)
Query: 254 QKVAVKILKDREAA---SKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGS 310
+ VA+K LK +A ++F EA++M H N++RL+G+V TS+ +V E+ A GS
Sbjct: 743 ETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVV-TSAEPVMIVAEYMANGS 801
Query: 311 LLDYLRSRG-RHYVTQLNQIN-FAFDACCGMEYLERQRVVHR-----DLAARNVLISAEG 363
L +LR+ R +I + GM+YL VHR DLAARNVL+ E
Sbjct: 802 LDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMEL 861
Query: 364 TAKVADFGXXXXXXXXXXXXX--XXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLW 421
K+ADFG K+P++WTAPEA+ + KF+ SD+WSFG+++W
Sbjct: 862 RCKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIW 921
Query: 422 EIYSFGRVPYPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHM 480
E+ SFG PY +V+ V GYR+ P CP G Y + + W + RPTF +
Sbjct: 922 EVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQL 980
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 151 bits (366), Expect = 4e-35
Identities = 94/283 (33%), Positives = 141/283 (49%), Gaps = 18/283 (6%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGIL---NGTQ-KVAVKILK----DREAASKFRAEASVM 277
++ L + + +G+GEFG VM G L +GT KVAVK +K + +F +EA+ M
Sbjct: 466 VERNLLNLGKVLGEGEFGSVMEGELQYSDGTNHKVAVKTMKMDNFSQREIEEFLSEAACM 525
Query: 278 ASLKHENLVRLLGLVFTSSGGTC----LVTEHCAQGSLLDYLRSR----GRHYVTQLNQI 329
H N++RLLG+ ++ G L +L S G +V +
Sbjct: 526 KDFNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIGSGPQHVPLRTLV 585
Query: 330 NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQ 389
F D GMEYL + +HRDLAARN ++ + T VADFG
Sbjct: 586 KFMIDIATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRI-- 643
Query: 390 AKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYRM 449
AK+P+KW A E+L ++ KSD+W+FG+ +WEI + G PYP + E+ ++ G+R+
Sbjct: 644 AKMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYLLVGHRL 703
Query: 450 EAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIRDHTP 492
+ P C Y +M W +DP RP+F +R NL I + P
Sbjct: 704 KQPPECLDDLYTVMYQCWLSDPTCRPSFTALRENLEKIVEGLP 746
>UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 709
Score = 151 bits (366), Expect = 4e-35
Identities = 95/281 (33%), Positives = 138/281 (49%), Gaps = 27/281 (9%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGTQK------VAVKILKDREAASKFRA--EASV- 276
I E+ L+I + IG+GEFG V L K VAVK +K + S+ E SV
Sbjct: 380 IPEQCLQIMDCIGQGEFGIVYRAYLREWAKYPSPHLVAVKTIKGETSDSQISQMLEESVK 439
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQ-------- 328
M H N++ L+G+ +V A GSLL YL+ + RH +T N
Sbjct: 440 MKDFDHPNILSLIGVCIAIESSPYIVMPFMANGSLLSYLKQQ-RHNLTIANGAEQDLITE 498
Query: 329 -----INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXX 383
++ GMEYL Q+ VHRDLAARN +I KVADFG
Sbjct: 499 TQRVLLSICLQIAKGMEYLASQKFVHRDLAARNCMIDLNNVIKVADFGLSEDMYAKNYYR 558
Query: 384 XXXXXQAK--LPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVR 441
+ K LPI+W APE+ FS K+D+WS+G+ WE+++ G++PYP + +++
Sbjct: 559 QSDVEECKVKLPIRWMAPESFHDGVFSEKTDVWSYGVTCWEVFTLGKIPYPGVTPFTLIK 618
Query: 442 HVERGYRMEAPE--GCPPGPYELMRAAWHADPASRPTFLHM 480
+++ G R+E P C Y+LMR W + RP F ++
Sbjct: 619 YLDEGGRLEKPSNAACSDQIYDLMRKCWCQESEDRPPFSNL 659
>UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=3;
Caenorhabditis|Rep: Protein kinase protein 9, isoform b
- Caenorhabditis elegans
Length = 615
Score = 151 bits (366), Expect = 4e-35
Identities = 100/287 (34%), Positives = 141/287 (49%), Gaps = 38/287 (13%)
Query: 224 WKIDERDLEIR--ENIGKGEFGDVMLGILNG------------TQ-----KVAVKILK-- 262
W +D +LEI + +G G F +V G +NG TQ VAVK+L
Sbjct: 294 WLLDRNNLEINYSKKLGSGAFCNVFKGKINGEAPVSQIHPGQRTQLLRDCPVAVKMLPSF 353
Query: 263 -DREAASKFRAEASVMASLK-HENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGR 320
D A S F E + M SL H +LV +LG V LV E C G LL +R+R +
Sbjct: 354 ADDAARSDFMQEINFMKSLAYHPHLVSMLGFVADRKSPYLLV-EFCEHGDLLHMIRNRRQ 412
Query: 321 HYVTQLNQ----------INFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADF 370
+ + + F++ G+EYL +HRD+AARNVL+ + T K+ DF
Sbjct: 413 EIINGPTENPDGLKIKDLLMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKIGDF 472
Query: 371 GXXXXXXXXXXXXXXXXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVP 430
G +LP+KW APE+L ++S KSD+WS+G+LLWE++S G VP
Sbjct: 473 GLCRLTDSLLYTARG----GRLPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVP 528
Query: 431 YPRIPLAEVVRHVERGYRMEAPEGCPPGPYELMRAAWHADPASRPTF 477
Y + E+++ G R+ PE CP Y++MR W P RP F
Sbjct: 529 YGEVQTTELLQTHRSGKRLLKPEWCPEEIYDVMRLCWQELPDDRPAF 575
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 151 bits (366), Expect = 4e-35
Identities = 94/275 (34%), Positives = 139/275 (50%), Gaps = 21/275 (7%)
Query: 224 WKIDERDLEIRENIGKGEFGDVMLGILNG------TQKVAVKILKDREAASK---FRAEA 274
W+++ + E +G+G FG V GIL Q A+K + + A + F EA
Sbjct: 1018 WEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLEA 1077
Query: 275 SVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQ--------L 326
SVM ++VRLLG+V + T ++ E A G L YLR Y + L
Sbjct: 1078 SVMKQFNTHHVVRLLGVV-SQGDPTLVIMELMANGDLKSYLRRHRPDYEMRRSIRQPPTL 1136
Query: 327 NQI-NFAFDACCGMEYLERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXX 385
QI A + G+ L ++ VHRDLAARN +++ + T K+ DFG
Sbjct: 1137 RQIIQMAIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTRDIYETDYYRKG 1196
Query: 386 XXXQAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVER 445
+ LP++W APE+LK FS+ SD++S+G++LWE+ + PY + +V+R+V
Sbjct: 1197 T--KGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVID 1254
Query: 446 GYRMEAPEGCPPGPYELMRAAWHADPASRPTFLHM 480
G ME PE CP Y LMR W P +RPTF+ +
Sbjct: 1255 GGVMERPENCPDNLYNLMRRCWQHRPTARPTFMEI 1289
>UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine
protein kinase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to tyrosine protein kinase - Nasonia vitripennis
Length = 1126
Score = 151 bits (365), Expect = 6e-35
Identities = 102/288 (35%), Positives = 146/288 (50%), Gaps = 38/288 (13%)
Query: 233 IRENIGKGEFGDVMLGILNGT-------QKVAVKILKDR--EAASK-FRAEASVMASLKH 282
++ IG+G +G+V LGI Q+VAVK LK R EA + F E +M +LKH
Sbjct: 839 LQGRIGQGFYGEVYLGICEKDSVKDAEPQQVAVKKLKMRALEADLRDFEREIEIMKTLKH 898
Query: 283 ENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLRSRGRHYVTQLNQINFAFDACCGMEYL 342
N+V +LG++ S CLV E GSL YL R +T + FA D GMEYL
Sbjct: 899 PNVVGILGVI--SEPEVCLVMEFVKHGSLQSYLAIH-RESLTNKRLLGFALDIATGMEYL 955
Query: 343 ERQRVVHRDLAARNVLISAEGTAKVADFGXXXXXXXXXXXXXXXXXQAKLPIKWTAPEAL 402
R +VHRDLAARN+L++ + K++DFG LPIKW APE+L
Sbjct: 956 GRMNIVHRDLAARNILVADDNRVKISDFG--LAQVTGKNDYYILQTNRDLPIKWYAPESL 1013
Query: 403 KYNKFSNKSDMWSFGILLWEIYSFGRVP-YPRIPL---------------------AEVV 440
+ KFS +SD+WSFG+ ++E +SFG P P A+++
Sbjct: 1014 RDGKFSPRSDVWSFGVTMYETFSFGEDPKLPEFGSNSVVEVEGSGKAVNTLEEEGGADLL 1073
Query: 441 RHVERGYRMEAPEGCPPGPY-ELMRAAWHADPASRPTFLHMRRNLADI 487
+ +ERG R+ P CP Y ++M W+ RP F + +++ D+
Sbjct: 1074 KALERGARLPCPATCPQEVYTKVMYPCWNIQSHERPEFAKLCKDIRDL 1121
Score = 50.8 bits (116), Expect = 8e-05
Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 392 LPIKWTAPEALKYNKFSNKS---DMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR 448
L + W PE + +S D+W+ LWEI+S G + + + G R
Sbjct: 612 LSVHWLPPECYGNPDLARRSIQADVWAIATTLWEIFSRGTILPSNTEPDPIKKFYASGKR 671
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTFLHMRRNLADIR 488
+ P GCPP Y+LM W SR + R++ I+
Sbjct: 672 LPIPNGCPPEVYKLMTDCWGEIGGSRKQPQAIMRDINQIK 711
Score = 39.9 bits (89), Expect = 0.16
Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 4/106 (3%)
Query: 255 KVAVKILKDREA--ASKFRAEASVMASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLL 312
+ A+K+LK+ E +F A L+ LVRL G+ S G L E G+L
Sbjct: 500 ETAIKLLKEDEGQPTKEFLKLAQKWGQLRSSALVRLYGVTLAPSVGMLL--ELVKLGALD 557
Query: 313 DYLRSRGRHYVTQLNQINFAFDACCGMEYLERQRVVHRDLAARNVL 358
YLR+ + ++ + A + +LE VVH ++ R +L
Sbjct: 558 AYLRNNSPQTIKTVDMVEAAACLATAVWHLEENGVVHGNIRCRKLL 603
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 151 bits (365), Expect = 6e-35
Identities = 96/269 (35%), Positives = 134/269 (49%), Gaps = 20/269 (7%)
Query: 226 IDERDLEIRENIGKGEFGDVMLGILNGT------QKVAVKILKDR---EAASKFRAEASV 276
I L + + +G+G FG+V G VAVK L + +A F EA +
Sbjct: 815 IPREQLRLVKALGQGAFGEVYQGFYRQRPCDTVEMPVAVKTLPEMSTSQAEMDFLMEALI 874
Query: 277 MASLKHENLVRLLGLVFTSSGGTCLVTEHCAQGSLLDYLR-SRGRHY----VTQLNQINF 331
M+ H N+V +G+ F +V E A G L ++LR SR + +T + +
Sbjct: 875 MSKFNHPNIVHFIGVCFDKHP-RFIVLELLAGGDLKNFLRESRPKPERGSPLTMKDLVLI 933
Query: 332 AFDACCGMEYLERQRVVHRDLAARNVLISAEG---TAKVADFGXXXXXXXXXXXXXXXXX 388
A D G +YLE R +HRD+AARN L++ +G K+ADFG
Sbjct: 934 AVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVVKIADFGMSRDVYRSDYYRKGG-- 991
Query: 389 QAKLPIKWTAPEALKYNKFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAEVVRHVERGYR 448
+A LPIKW PEA F++K+D+WSFG+LLWEI S G +PY EV++ V G R
Sbjct: 992 KAMLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSMGYMPYTGCANREVMQLVTSGGR 1051
Query: 449 MEAPEGCPPGPYELMRAAWHADPASRPTF 477
++ P CP Y +M WH P RPTF
Sbjct: 1052 LDPPANCPGPIYGIMTQCWHPTPEQRPTF 1080
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.320 0.134 0.413
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 555,081,038
Number of Sequences: 1657284
Number of extensions: 22599082
Number of successful extensions: 80802
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 4152
Number of HSP's successfully gapped in prelim test: 5569
Number of HSP's that attempted gapping in prelim test: 62438
Number of HSP's gapped (non-prelim): 12366
length of query: 514
length of database: 575,637,011
effective HSP length: 104
effective length of query: 410
effective length of database: 403,279,475
effective search space: 165344584750
effective search space used: 165344584750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 75 (34.3 bits)
- SilkBase 1999-2023 -