Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA001473-TA|BGIBMGA001473-PA|IPR004841|Amino acid
permease-associated region
(767 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U30246-1|AAC50561.1| 1212|Homo sapiens bumetanide-sensitive Na-K... 248 8e-65
BC033003-1|AAH33003.1| 1150|Homo sapiens SLC12A2 protein protein. 248 8e-65
AY280459-1|AAP33906.1| 1212|Homo sapiens bumetanide-sensitive Na... 248 8e-65
U58130-1|AAB07364.1| 1099|Homo sapiens bumetanide-sensitive Na-K... 239 3e-62
U44128-1|AAC50355.1| 1030|Homo sapiens thiazide-sensitive Na-Cl ... 228 5e-59
X91220-1|CAA62613.1| 1021|Homo sapiens NaCl electroneutral Thiaz... 223 2e-57
BC040138-1|AAH40138.1| 430|Homo sapiens SLC12A1 protein protein. 153 2e-36
AF439152-1|AAL32454.1| 311|Homo sapiens sodium-potassium-chlori... 119 3e-26
BC126160-1|AAI26161.1| 714|Homo sapiens solute carrier family 1... 115 7e-25
BC126158-1|AAI26159.1| 714|Homo sapiens solute carrier family 1... 115 7e-25
AF390442-1|AAM73657.1| 731|Homo sapiens solute carrier family 1... 115 7e-25
AF345197-1|AAO49174.1| 714|Homo sapiens cation-chloride cotrans... 115 7e-25
AF312032-7|AAK21009.1| 627|Homo sapiens cation-chloride cotrans... 99 5e-20
AF312032-6|AAK21008.1| 914|Homo sapiens cation-chloride cotrans... 99 5e-20
AB033284-1|BAB40456.1| 914|Homo sapiens cation chloride cotrans... 98 9e-20
AF284422-1|AAF88060.1| 914|Homo sapiens cation-chloride cotrans... 98 1e-19
AK129998-1|BAC85271.1| 342|Homo sapiens protein ( Homo sapiens ... 86 4e-16
AF389851-1|AAK94307.1| 584|Homo sapiens solute carrier family 1... 86 5e-16
AB209192-1|BAD92429.1| 122|Homo sapiens solute carrier family 1... 84 2e-15
BC000154-1|AAH00154.1| 538|Homo sapiens SLC12A9 protein protein. 72 7e-12
AK024421-1|BAB15711.1| 772|Homo sapiens FLJ00010 protein protein. 72 7e-12
AK024494-1|BAB15784.1| 672|Homo sapiens FLJ00100 protein protein. 66 4e-10
AK090458-1|BAC03439.1| 487|Homo sapiens FLJ00379 protein protein. 62 7e-09
AK024466-1|BAB15756.1| 477|Homo sapiens FLJ00059 protein protein. 62 7e-09
AK024420-1|BAB15710.1| 540|Homo sapiens FLJ00009 protein protein. 62 7e-09
U55054-1|AAC50563.1| 1085|Homo sapiens K-Cl cotransporter protein. 58 1e-07
BC021193-1|AAH21193.1| 1085|Homo sapiens solute carrier family 1... 58 1e-07
AF054506-1|AAC39685.1| 1068|Homo sapiens erythroid K:Cl cotransp... 58 1e-07
AF054505-1|AAC39684.1| 1011|Homo sapiens erythroid K:Cl cotransp... 58 1e-07
AF047338-1|AAC32815.1| 1085|Homo sapiens erythroid K:Cl cotransp... 58 1e-07
BC132670-1|AAI32671.1| 1116|Homo sapiens solute carrier family 1... 58 2e-07
BC132668-1|AAI32669.1| 1116|Homo sapiens solute carrier family 1... 58 2e-07
BC098390-1|AAH98390.1| 1083|Homo sapiens solute carrier family 1... 58 2e-07
AL162458-7|CAH74054.2| 1116|Homo sapiens solute carrier family 1... 58 2e-07
AK024497-1|BAB15787.1| 721|Homo sapiens FLJ00105 protein protein. 58 2e-07
AK024493-1|BAB15783.1| 780|Homo sapiens FLJ00098 protein protein. 58 2e-07
AF208159-1|AAG43493.1| 1116|Homo sapiens electroneutral potassiu... 58 2e-07
AF105365-1|AAD39741.1| 1083|Homo sapiens K-Cl cotransporter KCC4... 58 2e-07
AB033002-1|BAA86490.1| 1101|Homo sapiens KIAA1176 protein protein. 58 2e-07
DQ138323-1|ABA02873.1| 1141|Homo sapiens potassium chloride cotr... 52 8e-06
BC126243-1|AAI26244.1| 1099|Homo sapiens solute carrier family 1... 52 8e-06
BC126241-1|AAI26242.1| 1099|Homo sapiens solute carrier family 1... 52 8e-06
BC070107-1|AAH70107.2| 1091|Homo sapiens solute carrier family 1... 52 8e-06
AL117500-1|CAB55965.1| 1014|Homo sapiens hypothetical protein pr... 52 8e-06
AF531260-1|AAQ10028.1| 1091|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
AF531259-1|AAQ10027.1| 1091|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
AF531258-1|AAQ10026.1| 1135|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
AF477977-1|AAL85335.1| 1011|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
AF314956-2|AAM96216.1| 1099|Homo sapiens potassium-chloride tran... 52 8e-06
AF314956-1|AAM96215.1| 1150|Homo sapiens potassium-chloride tran... 52 8e-06
AF116242-1|AAF24986.1| 1150|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
AF108831-1|AAD25337.1| 1099|Homo sapiens K:Cl cotransporter 3 pr... 52 8e-06
AF105366-1|AAD39742.1| 1150|Homo sapiens K-Cl cotransporter KCC3... 52 8e-06
BC051744-1|AAH51744.1| 943|Homo sapiens SLC12A6 protein protein. 50 4e-05
AL162458-6|CAH74053.1| 285|Homo sapiens solute carrier family 1... 47 2e-04
BX538023-1|CAD97969.1| 525|Homo sapiens hypothetical protein pr... 46 7e-04
BC007760-1|AAH07760.1| 266|Homo sapiens SLC12A7 protein protein. 44 0.003
AF053402-1|AAC35282.1| 238|Homo sapiens erythrocyte K-Cl cotran... 38 0.10
BC063528-1|AAH63528.1| 338|Homo sapiens SLC12A8 protein protein. 36 0.54
>U30246-1|AAC50561.1| 1212|Homo sapiens bumetanide-sensitive Na-K-Cl
cotransporter protein.
Length = 1212
Score = 248 bits (606), Expect = 8e-65
Identities = 132/313 (42%), Positives = 182/313 (58%), Gaps = 22/313 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG YYL+SRSLG EFG ++G++FAFANAVA +M +GF +++ LLK H + ++D ++ND
Sbjct: 350 GGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EIND 408
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+GA+ ++++ I GM+WE KAQ L G I S ++ KGF
Sbjct: 409 IRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGFF 466
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + EN+ P+FR E FFSVFA++FPA TG+ AGANI GDL +P AIPKGT
Sbjct: 467 GYKSEIFNENFGPDFR----EEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGT 522
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNV--------ANLTTAA------LESCKPH-C 231
LLA+ I+ Y + + G +RDA+GNV N T+AA SC+ C
Sbjct: 523 LLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPC 582
Query: 232 GYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFS 291
YGL NN+ +M ++S + P I AG + P++ QAL D IYP F+
Sbjct: 583 SYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFA 642
Query: 292 KPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 643 KGYGKNNEPLRGY 655
Score = 119 bits (287), Expect = 3e-26
Identities = 60/168 (35%), Positives = 94/168 (55%), Gaps = 2/168 (1%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
DV+WGSST+ Y + + LS H +++ PQ LV+ G P RPAL+ + H TK
Sbjct: 755 DVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKN 814
Query: 378 GSFMIVADITDTALTKG--ERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQAS 435
MI + + E Q ++++ K++AFY + DL+ GA LMQA+
Sbjct: 815 VGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAA 874
Query: 436 GLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
GLG++ PN L++GFKKDW A+ + + Y + DAFD++ V ++R+
Sbjct: 875 GLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRL 922
Score = 115 bits (277), Expect = 5e-25
Identities = 64/189 (33%), Positives = 108/189 (57%), Gaps = 16/189 (8%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K +D WWL++DGGL +L+PY++ + +R+F I + ++ + + + M +LL KF
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF-IGGKINRIDHDRRAMATLLSKF 1079
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNIINDFKSEE---KTDILT----------SEAEL 698
RI+++++ ++ I P + + F II ++ E + DI ++ EL
Sbjct: 1080 RIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNEL 1139
Query: 699 KSQYSKTSXXXXXXXXXXQHSTKAAIVIITLPLPRK--VSASLYMAWLEVLSRDLPPVLF 756
+ +KT +HS+ A I++++LP+ RK VS++LYMAWLE LS+DLPP+L
Sbjct: 1140 ELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILL 1199
Query: 757 VRGNDSCVL 765
VRGN VL
Sbjct: 1200 VRGNHQSVL 1208
>BC033003-1|AAH33003.1| 1150|Homo sapiens SLC12A2 protein protein.
Length = 1150
Score = 248 bits (606), Expect = 8e-65
Identities = 132/313 (42%), Positives = 182/313 (58%), Gaps = 22/313 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG YYL+SRSLG EFG ++G++FAFANAVA +M +GF +++ LLK H + ++D ++ND
Sbjct: 350 GGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EIND 408
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+GA+ ++++ I GM+WE KAQ L G I S ++ KGF
Sbjct: 409 IRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGFF 466
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + EN+ P+FR E FFSVFA++FPA TG+ AGANI GDL +P AIPKGT
Sbjct: 467 GYKSEIFNENFGPDFR----EEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGT 522
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNV--------ANLTTAA------LESCKPH-C 231
LLA+ I+ Y + + G +RDA+GNV N T+AA SC+ C
Sbjct: 523 LLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPC 582
Query: 232 GYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFS 291
YGL NN+ +M ++S + P I AG + P++ QAL D IYP F+
Sbjct: 583 SYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFA 642
Query: 292 KPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 643 KGYGKNNEPLRGY 655
Score = 119 bits (287), Expect = 3e-26
Identities = 60/168 (35%), Positives = 94/168 (55%), Gaps = 2/168 (1%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
DV+WGSST+ Y + + LS H +++ PQ LV+ G P RPAL+ + H TK
Sbjct: 755 DVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKN 814
Query: 378 GSFMIVADITDTALTKG--ERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQAS 435
MI + + E Q ++++ K++AFY + DL+ GA LMQA+
Sbjct: 815 VGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAA 874
Query: 436 GLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
GLG++ PN L++GFKKDW A+ + + Y + DAFD++ V ++R+
Sbjct: 875 GLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRL 922
Score = 66.1 bits (154), Expect = 4e-10
Identities = 28/96 (29%), Positives = 56/96 (58%), Gaps = 1/96 (1%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K +D WWL++DGGL +L+PY++ + +R+F I + ++ + + + M +LL KF
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF-IGGKINRIDHDRRAMATLLSKF 1079
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNIINDFKSEE 687
RI+++++ ++ I P + + F II ++ E
Sbjct: 1080 RIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHE 1115
>AY280459-1|AAP33906.1| 1212|Homo sapiens bumetanide-sensitive
Na-K-Cl cotransporter protein.
Length = 1212
Score = 248 bits (606), Expect = 8e-65
Identities = 132/313 (42%), Positives = 182/313 (58%), Gaps = 22/313 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG YYL+SRSLG EFG ++G++FAFANAVA +M +GF +++ LLK H + ++D ++ND
Sbjct: 350 GGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EIND 408
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+GA+ ++++ I GM+WE KAQ L G I S ++ KGF
Sbjct: 409 IRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES--KKPKGFF 466
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + EN+ P+FR E FFSVFA++FPA TG+ AGANI GDL +P AIPKGT
Sbjct: 467 GYKSEIFNENFGPDFR----EEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGT 522
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNV--------ANLTTAA------LESCKPH-C 231
LLA+ I+ Y + + G +RDA+GNV N T+AA SC+ C
Sbjct: 523 LLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPC 582
Query: 232 GYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFS 291
YGL NN+ +M ++S + P I AG + P++ QAL D IYP F+
Sbjct: 583 SYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFA 642
Query: 292 KPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 643 KGYGKNNEPLRGY 655
Score = 119 bits (287), Expect = 3e-26
Identities = 60/168 (35%), Positives = 94/168 (55%), Gaps = 2/168 (1%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
DV+WGSST+ Y + + LS H +++ PQ LV+ G P RPAL+ + H TK
Sbjct: 755 DVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKN 814
Query: 378 GSFMIVADITDTALTKG--ERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQAS 435
MI + + E Q ++++ K++AFY + DL+ GA LMQA+
Sbjct: 815 VGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAA 874
Query: 436 GLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
GLG++ PN L++GFKKDW A+ + + Y + DAFD++ V ++R+
Sbjct: 875 GLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRL 922
Score = 115 bits (277), Expect = 5e-25
Identities = 64/189 (33%), Positives = 108/189 (57%), Gaps = 16/189 (8%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K +D WWL++DGGL +L+PY++ + +R+F I + ++ + + + M +LL KF
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF-IGGKINRIDHDRRAMATLLSKF 1079
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNIINDFKSEE---KTDILT----------SEAEL 698
RI+++++ ++ I P + + F II ++ E + DI ++ EL
Sbjct: 1080 RIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNEL 1139
Query: 699 KSQYSKTSXXXXXXXXXXQHSTKAAIVIITLPLPRK--VSASLYMAWLEVLSRDLPPVLF 756
+ +KT +HS+ A I++++LP+ RK VS++LYMAWLE LS+DLPP+L
Sbjct: 1140 ELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILL 1199
Query: 757 VRGNDSCVL 765
VRGN VL
Sbjct: 1200 VRGNHQSVL 1208
>U58130-1|AAB07364.1| 1099|Homo sapiens bumetanide-sensitive
Na-K-2Cl cotransporter protein.
Length = 1099
Score = 239 bits (584), Expect = 3e-62
Identities = 126/313 (40%), Positives = 181/313 (57%), Gaps = 21/313 (6%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG YYL+SRSLG EFG S+G++FAFANAVA +M +GF +++ LLK +VD ND
Sbjct: 242 GGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVD-PTND 300
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+G++ ++++ I GM+WE KAQ L G +I PS++ ++++GF
Sbjct: 301 IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVI-PSNNEKKSRGFF 359
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
EN+ P F EG FFSVFA++FPA TG+ AGANI GDL++P AIP+GT
Sbjct: 360 NYQASIFAENFGPRFTKGEG----FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGT 415
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNVANLTTAAL--------------ESCKPH-C 231
+LA+ I+ +Y + I G +RDA+GN+ + + + C+ C
Sbjct: 416 MLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPC 475
Query: 232 GYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFS 291
YGL NN+ +M ++S +GP I AG + P++ QAL D IY L FF+
Sbjct: 476 QYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535
Query: 292 KPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 536 KGYGKNNEPLRGY 548
Score = 123 bits (297), Expect = 2e-27
Identities = 61/168 (36%), Positives = 95/168 (56%), Gaps = 2/168 (1%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
DV+WGSST+ Y + EL+ H +++ PQ +VL G P+ RPAL+D+ H TK
Sbjct: 648 DVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKN 707
Query: 378 GSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQAS 435
I ++ L E S + ++ K++AFY + + G +L+QAS
Sbjct: 708 SGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQAS 767
Query: 436 GLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
GLG++ PN L+IG+KK+W A +I +Y G+I DAFD ++ V I+R+
Sbjct: 768 GLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRI 815
Score = 122 bits (295), Expect = 4e-27
Identities = 70/189 (37%), Positives = 108/189 (57%), Gaps = 16/189 (8%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K +D WWL++DGGL +L+PYI+ R LRI+ + + ++ E E M SLL KF
Sbjct: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIY-VGGKINRIEEEKIAMASLLSKF 966
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNIINDFKSEEK-TDILTSE------------AEL 698
RI++ ++ ++ I P + SWK+F +I ++ E D+ T+E AEL
Sbjct: 967 RIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAEL 1026
Query: 699 KSQYSKTSXXXXXXXXXXQHSTKAAIVIITLPLPRKVSAS--LYMAWLEVLSRDLPPVLF 756
++ K+ +HS A +++++LP+ RK S S LYMAWLE+L+++LPPVL
Sbjct: 1027 EAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLL 1086
Query: 757 VRGNDSCVL 765
VRGN VL
Sbjct: 1087 VRGNHKNVL 1095
>U44128-1|AAC50355.1| 1030|Homo sapiens thiazide-sensitive Na-Cl
protein.
Length = 1030
Score = 228 bits (558), Expect = 5e-59
Identities = 123/314 (39%), Positives = 178/314 (56%), Gaps = 21/314 (6%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG Y+L+SRSLG E G S+G++FAFANAV +M+T+GF +++ LL+ +G IVD +ND
Sbjct: 201 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVD-PIND 259
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+G V++ V+ I GM+WE+KAQ G LI PS D + +KGF
Sbjct: 260 IRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED-KASKGFF 318
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
+N +P++R +G FF +F+++FP+ TG+ AGANI GDLK+PA+AIPKGT
Sbjct: 319 SYRADIFVQNLVPDWRGPDGT---FFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGT 375
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNVANLTTAALESC---------------KPH- 230
L+A+ + SY + G +RDASG + + T +C + H
Sbjct: 376 LMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHS 435
Query: 231 CGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFF 290
C YGL N Y M ++S + P I AG + ++ Q L D++YP + FF
Sbjct: 436 CHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFF 495
Query: 291 SKPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 496 GKGYGKNKEPVRGY 509
Score = 122 bits (293), Expect = 6e-27
Identities = 64/169 (37%), Positives = 94/169 (55%), Gaps = 4/169 (2%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
+V+WGSS + Y +S+ L+ H ++Y PQ LVL G P RPAL+D T+
Sbjct: 609 EVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRN 668
Query: 378 GSFMIVADITDTALTKGERVSRQHIGEQFVKY---RKLRAFYVLLQGLDLKRGANALMQA 434
S MI + K Q I K+ RK++AFY + DL+RG LMQA
Sbjct: 669 LSLMICGHVL-IGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQA 727
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
+GLG++ PNIL++GFKK+W +A + DY G++ DAF+ V ++R+
Sbjct: 728 AGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFEFNYGVCVMRM 776
Score = 106 bits (254), Expect = 3e-22
Identities = 66/190 (34%), Positives = 105/190 (55%), Gaps = 17/190 (8%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K+ +D +WL++DGGL +L+PY++ R+ K +R+F + + ++ + E K + SLL KF
Sbjct: 837 KKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF-VGGQINRMDQERKAIISLLSKF 895
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNII-----ND-FKSEEKTDIL-------TSEAEL 698
R+ + E+ ++ I P K F ++I ND FK E + + S+ E+
Sbjct: 896 RLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEI 955
Query: 699 KSQYSKTSXXXXXXXXXXQHSTKAAIVIITLPLPR--KVSASLYMAWLEVLSRDL-PPVL 755
K+ +S AA+++ITLP+ R K +SLYMAWLE LS+DL PPV+
Sbjct: 956 TKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVI 1015
Query: 756 FVRGNDSCVL 765
+RGN VL
Sbjct: 1016 LIRGNQENVL 1025
>X91220-1|CAA62613.1| 1021|Homo sapiens NaCl electroneutral
Thiazide-sensitive cotransporter protein.
Length = 1021
Score = 223 bits (545), Expect = 2e-57
Identities = 121/314 (38%), Positives = 176/314 (56%), Gaps = 21/314 (6%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG Y+L+SRSLG E G S+G++FAFANAV +M+T+GF +++ LL+ +G IVD +ND
Sbjct: 201 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVD-PIND 259
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+G V++ V+ I GM+WE+KAQ G LI PS D + +KGF
Sbjct: 260 IRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSED-KASKGFF 318
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
+N +P++R +G FF +F+++FP+ TG+ AGANI GDLK+PA+AIPKGT
Sbjct: 319 SYRADIFVQNLVPDWRGPDGT---FFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGT 375
Query: 187 LLALAISVTSYFTMVILSGMGALRDASGNVANLTTAALESC---------------KPH- 230
L+A+ + SY + G +RDASG + + T +C + H
Sbjct: 376 LMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHS 435
Query: 231 CGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFF 290
C YGL N Y M ++S + P I + ++ Q L D++YP + FF
Sbjct: 436 CHYGLINYYQTMSMVSGFAPLITVVIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFF 495
Query: 291 SKPYGRHGEPYRGY 304
K YG++ EP RGY
Sbjct: 496 GKGYGKNKEPVRGY 509
Score = 123 bits (297), Expect = 2e-27
Identities = 65/169 (38%), Positives = 94/169 (55%), Gaps = 4/169 (2%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
+V+WGSS + Y +S+ L+ H ++Y PQ LVL G P RPAL+D T+
Sbjct: 609 EVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRN 668
Query: 378 GSFMIVADITDTALTKGERVSRQHIGEQFVKY---RKLRAFYVLLQGLDLKRGANALMQA 434
S MI + K Q I K+ RK++AFY + DL+RG LMQA
Sbjct: 669 LSLMICGHVL-IGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQA 727
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
+GLG++ PNIL++GFKK+W +A + DY G++ DAFD V ++R+
Sbjct: 728 AGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRM 776
Score = 106 bits (254), Expect = 3e-22
Identities = 66/190 (34%), Positives = 105/190 (55%), Gaps = 17/190 (8%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKF 651
K+ +D +WL++DGGL +L+PY++ R+ K +R+F + + ++ + E K + SLL KF
Sbjct: 828 KKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF-VGGQINRMDQERKAIISLLSKF 886
Query: 652 RIEYTELTLVRGIGDAPPESSWKMFNNII-----ND-FKSEEKTDIL-------TSEAEL 698
R+ + E+ ++ I P K F ++I ND FK E + + S+ E+
Sbjct: 887 RLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEI 946
Query: 699 KSQYSKTSXXXXXXXXXXQHSTKAAIVIITLPLPR--KVSASLYMAWLEVLSRDL-PPVL 755
K+ +S AA+++ITLP+ R K +SLYMAWLE LS+DL PPV+
Sbjct: 947 TKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVI 1006
Query: 756 FVRGNDSCVL 765
+RGN VL
Sbjct: 1007 LIRGNQENVL 1016
>BC040138-1|AAH40138.1| 430|Homo sapiens SLC12A1 protein protein.
Length = 430
Score = 153 bits (371), Expect = 2e-36
Identities = 81/183 (44%), Positives = 112/183 (61%), Gaps = 10/183 (5%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GG YYL+SRSLG EFG S+G++FAFANAVA +M +GF +++ LLK +VD ND
Sbjct: 242 GGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVD-PTND 300
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
IRI+G++ ++++ I GM+WE KAQ L G +I PS++ ++++GF
Sbjct: 301 IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVI-PSNNEKKSRGFF 359
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDL----KNPAVAI 182
EN+ P F EG FFSVFA++FPA TG+ AGANI GDL K A +
Sbjct: 360 NYQASIFAENFGPRFTKGEG----FFSVFAIFFPAATGILAGANISGDLEALRKQGASPL 415
Query: 183 PKG 185
P+G
Sbjct: 416 PQG 418
>AF439152-1|AAL32454.1| 311|Homo sapiens sodium-potassium-chloride
cotransporter protein.
Length = 311
Score = 119 bits (287), Expect = 3e-26
Identities = 60/168 (35%), Positives = 94/168 (55%), Gaps = 2/168 (1%)
Query: 318 DVSWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKI 377
DV+WGSST+ Y + + LS H +++ PQ LV+ G P RPAL+ + H TK
Sbjct: 16 DVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKN 75
Query: 378 GSFMIVADITDTALTKG--ERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQAS 435
MI + + E Q ++++ K++AFY + DL+ GA LMQA+
Sbjct: 76 VGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAA 135
Query: 436 GLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQDAFDLKLAVTILRV 483
GLG++ PN L++GFKKDW A+ + + Y + DAFD++ V ++R+
Sbjct: 136 GLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRL 183
Score = 43.2 bits (97), Expect = 0.004
Identities = 14/37 (37%), Positives = 24/37 (64%)
Query: 592 KQYVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIF 628
K +D WWL++DGGL +L+PY++ + +R+F
Sbjct: 266 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF 302
>BC126160-1|AAI26161.1| 714|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 8 protein.
Length = 714
Score = 115 bits (276), Expect = 7e-25
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 15/206 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GGVY ++S LG + G ++G+L+ F VA +M GF +S++ LL GL ++
Sbjct: 104 GGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---GL----GNIWA 156
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
+R + LL + I G+ W + Q L ++G + ++ GF+
Sbjct: 157 VRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDF----VVGSFTHLDPEHGFI 212
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + + ++ N LP+ YS G FF+VF V+FPA TGV AG N+ GDL+ PA +IP G+
Sbjct: 213 GYSPELLQNNTLPD--YSPGES--FFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 268
Query: 187 LLALAISVTSYFTMVILSGMGALRDA 212
L A+ IS Y V L G R+A
Sbjct: 269 LAAVGISWFLYIVFVFLLGAICTREA 294
>BC126158-1|AAI26159.1| 714|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 8 protein.
Length = 714
Score = 115 bits (276), Expect = 7e-25
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 15/206 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GGVY ++S LG + G ++G+L+ F VA +M GF +S++ LL GL ++
Sbjct: 104 GGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---GL----GNIWA 156
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
+R + LL + I G+ W + Q L ++G + ++ GF+
Sbjct: 157 VRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDF----VVGSFTHLDPEHGFI 212
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + + ++ N LP+ YS G FF+VF V+FPA TGV AG N+ GDL+ PA +IP G+
Sbjct: 213 GYSPELLQNNTLPD--YSPGES--FFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 268
Query: 187 LLALAISVTSYFTMVILSGMGALRDA 212
L A+ IS Y V L G R+A
Sbjct: 269 LAAVGISWFLYIVFVFLLGAICTREA 294
>AF390442-1|AAM73657.1| 731|Homo sapiens solute carrier family 12
member 8 protein.
Length = 731
Score = 115 bits (276), Expect = 7e-25
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 15/206 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GGVY ++S LG + G ++G+L+ F VA +M GF +S++ LL GL ++
Sbjct: 121 GGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---GL----GNIWA 173
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
+R + LL + I G+ W + Q L ++G + ++ GF+
Sbjct: 174 VRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDF----VVGSFTHLDPEHGFI 229
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + + ++ N LP+ YS G FF+VF V+FPA TGV AG N+ GDL+ PA +IP G+
Sbjct: 230 GYSPELLQNNTLPD--YSPGES--FFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 285
Query: 187 LLALAISVTSYFTMVILSGMGALRDA 212
L A+ IS Y V L G R+A
Sbjct: 286 LAAVGISWFLYIVFVFLLGAICTREA 311
>AF345197-1|AAO49174.1| 714|Homo sapiens cation-chloride
cotransporter 9 protein.
Length = 714
Score = 115 bits (276), Expect = 7e-25
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 15/206 (7%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDNDVND 66
GGVY ++S LG + G ++G+L+ F VA +M GF +S++ LL GL ++
Sbjct: 104 GGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---GL----GNIWA 156
Query: 67 IRIVGAVALLVMCVICAIGMDWETKAQNFLXXXXXXXXXXXXXGALIGPSSDVERAKGFV 126
+R + LL + I G+ W + Q L ++G + ++ GF+
Sbjct: 157 VRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDF----VVGSFTHLDPEHGFI 212
Query: 127 GINLQTIRENWLPNFRYSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGT 186
G + + ++ N LP+ YS G FF+VF V+FPA TGV AG N+ GDL+ PA +IP G+
Sbjct: 213 GYSPELLQNNTLPD--YSPGES--FFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 268
Query: 187 LLALAISVTSYFTMVILSGMGALRDA 212
L A+ IS Y V L G R+A
Sbjct: 269 LAAVGISWFLYIVFVFLLGAICTREA 294
>AF312032-7|AAK21009.1| 627|Homo sapiens cation-chloride
cotransporter-interacting protein 1 isoform b protein.
Length = 627
Score = 99.1 bits (236), Expect = 5e-20
Identities = 81/321 (25%), Positives = 137/321 (42%), Gaps = 45/321 (14%)
Query: 3 ASERGGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTH-----GL 57
A + GG Y+++SR+LG E G S+G++F AN +++ +G +S+ + GL
Sbjct: 98 AVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGL 157
Query: 58 KIVDNDVNDIRIVGAVALLVMCVICAIGMDWETKAQ--NFLXXXXXXXXXXXXXGALIGP 115
+++ + G++ L ++ +C +G +A FL A +GP
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVA-VGP 216
Query: 116 -------------SSDVERAKGFVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFP 160
SS R F G N T+++N + Y+ G +F SVFAV F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 276
Query: 161 AVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLT 220
TG+ AGAN+ G+LK+P+ AIP GT++A+A + Y + LS R
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL-------- 328
Query: 221 TAALESCKPHCGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGV 280
L +Y + +S W P + G + R++ AL
Sbjct: 329 --------------LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALAR 374
Query: 281 DRIYPGLIFFSKPYGRHGEPY 301
D ++ ++ +K R G P+
Sbjct: 375 DDLFGVILAPAKVVSRGGNPW 395
Score = 44.8 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 4/121 (3%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 500 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 558
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 559 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 618
Query: 437 L 437
L
Sbjct: 619 L 619
>AF312032-6|AAK21008.1| 914|Homo sapiens cation-chloride
cotransporter-interacting protein 1 protein.
Length = 914
Score = 99.1 bits (236), Expect = 5e-20
Identities = 81/321 (25%), Positives = 137/321 (42%), Gaps = 45/321 (14%)
Query: 3 ASERGGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTH-----GL 57
A + GG Y+++SR+LG E G S+G++F AN +++ +G +S+ + GL
Sbjct: 98 AVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGL 157
Query: 58 KIVDNDVNDIRIVGAVALLVMCVICAIGMDWETKAQ--NFLXXXXXXXXXXXXXGALIGP 115
+++ + G++ L ++ +C +G +A FL A +GP
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVA-VGP 216
Query: 116 -------------SSDVERAKGFVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFP 160
SS R F G N T+++N + Y+ G +F SVFAV F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFN 276
Query: 161 AVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLT 220
TG+ AGAN+ G+LK+P+ AIP GT++A+A + Y + LS R
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL-------- 328
Query: 221 TAALESCKPHCGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGV 280
L +Y + +S W P + G + R++ AL
Sbjct: 329 --------------LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALAR 374
Query: 281 DRIYPGLIFFSKPYGRHGEPY 301
D ++ ++ +K R G P+
Sbjct: 375 DDLFGVILAPAKVVSRGGNPW 395
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 500 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 558
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 559 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 618
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 619 LGGMKPNTLVLGFYDDAPPQDH 640
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 762 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 819
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 820 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 879
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 880 PARYPRYLALLETLTRDLGPTLLVHG 905
>AB033284-1|BAB40456.1| 914|Homo sapiens cation chloride
cotransporter 6 protein.
Length = 914
Score = 98.3 bits (234), Expect = 9e-20
Identities = 79/320 (24%), Positives = 136/320 (42%), Gaps = 43/320 (13%)
Query: 3 ASERGGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTH-----GL 57
A + GG Y+++SR+LG E G S+G++F AN +++ +G +S+ + GL
Sbjct: 98 AVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGL 157
Query: 58 KIVDNDVNDIRIVGAVALLVMCVICAIGMDWETKAQ--NFLXXXXXXXXXXXXXGAL--- 112
+++ + G++ L ++ +C +G +A FL A+
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
Query: 113 -------IGPSSDV--ERAKGFVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFPA 161
GP+ R F G N T+++N + Y+ G +F SVFAV F
Sbjct: 218 DIRLSPRPGPNGSALPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNG 277
Query: 162 VTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLTT 221
TG+ AGAN+ G+LK+P+ AIP GT++A+A + Y + LS R
Sbjct: 278 CTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL--------- 328
Query: 222 AALESCKPHCGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVD 281
L +Y + +S W P + G + R++ AL D
Sbjct: 329 -------------LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARD 375
Query: 282 RIYPGLIFFSKPYGRHGEPY 301
++ ++ +K R G P+
Sbjct: 376 DLFGVILAPAKVVSRGGNPW 395
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 500 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 558
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 559 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 618
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 619 LGGMKPNTLVLGFYDDAPPQDH 640
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 762 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 819
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 820 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPKGGDAEGPITALTFLYLPRPPAD 879
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 880 PARYPRYLALLETLTRDLGPTLLVHG 905
>AF284422-1|AAF88060.1| 914|Homo sapiens cation-chloride
cotransporter-interacting protein protein.
Length = 914
Score = 97.9 bits (233), Expect = 1e-19
Identities = 80/321 (24%), Positives = 137/321 (42%), Gaps = 45/321 (14%)
Query: 3 ASERGGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTH-----GL 57
A + GG Y+++SR+LG E G S+G++F AN +++ +G +S+ + GL
Sbjct: 98 AVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGL 157
Query: 58 KIVDNDVNDIRIVGAVALLVMCVICAIGMDWETKAQ--NFLXXXXXXXXXXXXXGALIGP 115
+++ + G++ L ++ +C +G +A FL A +GP
Sbjct: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVA-VGP 216
Query: 116 -------------SSDVERAKGFVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFP 160
SS R F G N T+++N + Y+ G +F +VFAV F
Sbjct: 217 RDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFANVFAVLFN 276
Query: 161 AVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLT 220
TG+ AGAN+ G+LK+P+ AIP GT++A+A + Y + LS R
Sbjct: 277 GCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL-------- 328
Query: 221 TAALESCKPHCGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGV 280
L +Y + +S W P + G + R++ AL
Sbjct: 329 --------------LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALAR 374
Query: 281 DRIYPGLIFFSKPYGRHGEPY 301
D ++ ++ +K R G P+
Sbjct: 375 DDLFGVILAPAKVVSRGGNPW 395
Score = 61.7 bits (143), Expect = 9e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 500 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 558
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 559 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTFSPSVRQGAQHLLRISG 618
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 619 LGGMKPNTLVLGFYDDAPPQDH 640
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 762 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 819
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 820 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 879
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 880 PARYPRYLALLETLTRDLGPTLLVHG 905
>AK129998-1|BAC85271.1| 342|Homo sapiens protein ( Homo sapiens
cDNA FLJ26488 fis, clone KDN05770, highly similar to
Bumetanide-sensitive sodium-(potassium)-chloride
cotransporter 2. ).
Length = 342
Score = 86.2 bits (204), Expect = 4e-16
Identities = 45/134 (33%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
Query: 323 SSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGSFMI 382
SST+ Y + EL+ H +++ PQ +VL G P+ RPAL+D+ H TK I
Sbjct: 47 SSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCI 106
Query: 383 VADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASGLGKL 440
++ L E S + ++ K++AFY + + G +L+QASGLG++
Sbjct: 107 CCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRM 166
Query: 441 SPNILLIGFKKDWT 454
PN L+IG+KK+W+
Sbjct: 167 KPNTLVIGYKKNWS 180
Score = 52.8 bits (121), Expect = 4e-06
Identities = 23/61 (37%), Positives = 32/61 (52%)
Query: 244 LMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEPYRG 303
++S +GP I AG + P++ QAL D Y L FF+K YG++ EP RG
Sbjct: 181 MVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNFYKALQFFAKGYGKNNEPLRG 240
Query: 304 Y 304
Y
Sbjct: 241 Y 241
>AF389851-1|AAK94307.1| 584|Homo sapiens solute carrier family 12
member 8 protein.
Length = 584
Score = 85.8 bits (203), Expect = 5e-16
Identities = 60/178 (33%), Positives = 89/178 (50%), Gaps = 15/178 (8%)
Query: 35 VAASMNTIGFCDSLNHLLKTHGLKIVDNDVNDIRIVGAVALLVMCVICAIGMDWETKAQN 94
VA +M GF +S++ LL GL ++ +R + LL + I G+ W Q
Sbjct: 2 VAGAMYITGFAESISDLL---GL----GNIWAVRGISVAVLLALLGINLAGVKWIICLQL 54
Query: 95 FLXXXXXXXXXXXXXGALIGPSSDVERAKGFVGINLQTIRENWLPNFRYSEGREHDFFSV 154
L ++G + ++ GF+G + + ++ N LP+ YS G FF+V
Sbjct: 55 LLLFLLAVSTLDF----VVGSFTHLDPEHGFIGYSPELLQNNTLPD--YSPGES--FFTV 106
Query: 155 FAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDA 212
F V+FPA TGV AG N+ GDL+ PA +IP G+L A+ IS Y V L G R+A
Sbjct: 107 FGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 164
>AB209192-1|BAD92429.1| 122|Homo sapiens solute carrier family 12
(sodium/potassium/chloride transporters), member 2 var
protein.
Length = 122
Score = 83.8 bits (198), Expect = 2e-15
Identities = 44/120 (36%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 352 PQLLVLAGTPLQRPALIDVAHMLTKIGSFMIVADITDTALTKG--ERVSRQHIGEQFVKY 409
PQ LV+ G P RPAL+ + H TK MI + + E Q ++++
Sbjct: 3 PQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIK 62
Query: 410 RKLRAFYVLLQGLDLKRGANALMQASGLGKLSPNILLIGFKKDWTNAEHKQISDYYGVIQ 469
K++AFY + DL+ GA LMQA+GLG++ PN L++GFKKDW A+ + + Y + Q
Sbjct: 63 NKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFQ 122
>BC000154-1|AAH00154.1| 538|Homo sapiens SLC12A9 protein protein.
Length = 538
Score = 72.1 bits (169), Expect = 7e-12
Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 24/179 (13%)
Query: 125 FVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAI 182
F G N T+++N + Y+ G +F SVFAV F TG+ AGAN+ G+LK+P+ AI
Sbjct: 150 FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAI 209
Query: 183 PKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLTTAALESCKPHCGYGLHNNYAIM 242
P GT++A+A + Y + LS R L +Y
Sbjct: 210 PLGTIVAVAYTFFVYVLLFFLSSFTCDRTL----------------------LQEDYGFF 247
Query: 243 QLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEPY 301
+ +S W P + G + R++ AL D ++ ++ +K R G P+
Sbjct: 248 RAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPW 306
Score = 44.8 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 4/121 (3%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 411 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 469
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 470 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 529
Query: 437 L 437
L
Sbjct: 530 L 530
>AK024421-1|BAB15711.1| 772|Homo sapiens FLJ00010 protein protein.
Length = 772
Score = 72.1 bits (169), Expect = 7e-12
Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 24/179 (13%)
Query: 125 FVGINLQTIRENWLPNFR--YSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAI 182
F G N T+++N + Y+ G +F SVFAV F TG+ AGAN+ G+LK+P+ AI
Sbjct: 97 FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAI 156
Query: 183 PKGTLLALAISVTSYFTMVILSGMGALRDASGNVANLTTAALESCKPHCGYGLHNNYAIM 242
P GT++A+A + Y + LS R L +Y
Sbjct: 157 PLGTIVAVAYTFFVYVLLFFLSSFTCDRTL----------------------LQEDYGFF 194
Query: 243 QLMSAWGPFIYAGCWXXXXXXXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEPY 301
+ +S W P + G + R++ AL D ++ ++ +K R G P+
Sbjct: 195 RAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPW 253
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 358 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 416
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 417 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 476
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 477 LGGMKPNTLVLGFYDDAPPQDH 498
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 620 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 677
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 678 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 737
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 738 PARYPRYLALLETLTRDLGPTLLVHG 763
>AK024494-1|BAB15784.1| 672|Homo sapiens FLJ00100 protein protein.
Length = 672
Score = 66.1 bits (154), Expect = 4e-10
Identities = 44/159 (27%), Positives = 69/159 (43%), Gaps = 22/159 (13%)
Query: 143 YSEGREHDFFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVI 202
Y+ G +F SVFAV F TG+ AGAN+ G+LK+P+ AIP GT++A+A + Y +
Sbjct: 17 YTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFF 76
Query: 203 LSGMGALRDASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAWGPFIYAGCWXXXXX 262
LS R L +Y + +S W P + G +
Sbjct: 77 LSSFTCDRTL----------------------LQEDYGFFRAISLWPPLVLIGIYATALS 114
Query: 263 XXXXXXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEPY 301
R++ AL D ++ ++ +K R G P+
Sbjct: 115 ASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPW 153
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 258 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 316
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 317 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 376
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 377 LGGMKPNTLVLGFYDDAPPQDH 398
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 520 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 577
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 578 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 637
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 638 PARYPRYLALLETLTRDLGPTLLVHG 663
>AK090458-1|BAC03439.1| 487|Homo sapiens FLJ00379 protein protein.
Length = 487
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 126 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 184
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 185 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 244
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 245 LGGMKPNTLVLGFYDDAPPQDH 266
>AK024466-1|BAB15756.1| 477|Homo sapiens FLJ00059 protein protein.
Length = 477
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 63 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 121
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 122 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 181
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 182 LGGMKPNTLVLGFYDDAPPQDH 203
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 325 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 382
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 383 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 442
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 443 PARYPRYLALLETLTRDLGPTLLVHG 468
>AK024420-1|BAB15710.1| 540|Homo sapiens FLJ00009 protein protein.
Length = 540
Score = 62.1 bits (144), Expect = 7e-09
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 320 SWGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQRPALIDVAHMLTKIGS 379
SWG ++ + ++ L R H + + PQLL+L G P L+ +A+ L K G
Sbjct: 126 SWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKK-GG 184
Query: 380 FMIVADIT--DTALTKGERVSRQH-IGEQFVKYRKLRAFYVLLQGLDLKRGANALMQASG 436
++ +T D + V Q+ V +++AF L +++GA L++ SG
Sbjct: 185 LYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISG 244
Query: 437 LGKLSPNILLIGFKKDWTNAEH 458
LG + PN L++GF D +H
Sbjct: 245 LGGMKPNTLVLGFYDDAPPQDH 266
Score = 36.3 bits (80), Expect = 0.41
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 621 HKLPLRIFAITKEQHKREFENKCMESLLKKFRI--EYTELTLVRGIGDAPPESSWKMFNN 678
H LRIF + + +LL + RI E E+ G G PE+ + +
Sbjct: 388 HSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEE--GD 445
Query: 679 IINDFKSEEKTDILTSEAE--LKSQYSK-TSXXXXXXXXXXQHSTKAAIVIITLPLPRKV 735
+N + + + + L A +++Q + T A+ + LP P
Sbjct: 446 FVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPAD 505
Query: 736 SASL--YMAWLEVLSRDLPPVLFVRG 759
A Y+A LE L+RDL P L V G
Sbjct: 506 PARYPRYLALLETLTRDLGPTLLVHG 531
>U55054-1|AAC50563.1| 1085|Homo sapiens K-Cl cotransporter protein.
Length = 1085
Score = 58.0 bits (134), Expect = 1e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP GT+LA+ + YF+ V+L G
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G G+ N + L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKYGDGVSRNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEP 554
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSL-------NHLLKTHGLKI 59
GG Y+++SRSLG EFG +VG+ F AA+M +G + L + G
Sbjct: 183 GGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHD 242
Query: 60 VDN-DVNDIRIVGAVALLVMCVICAIGMDWETK 91
N +N++R+ G + L M ++ +G+ + K
Sbjct: 243 TSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 377 IGSFMIVADITDTALTK--GERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + + GE + + + ++ K++ F ++ ++ G L+Q+
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAE 457
GLG + N +++G+ W +E
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSE 803
Score = 41.5 bits (93), Expect = 0.011
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K + L R+
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRL 904
Query: 654 E 654
E
Sbjct: 905 E 905
>BC021193-1|AAH21193.1| 1085|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 4 protein.
Length = 1085
Score = 58.0 bits (134), Expect = 1e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP GT+LA+ + YF+ V+L G
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G G+ N + L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKYGDGVSRNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEP 554
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSL-------NHLLKTHGLKI 59
GG Y+++SRSLG EFG +VG+ F AA+M +G + L + G
Sbjct: 183 GGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHD 242
Query: 60 VDN-DVNDIRIVGAVALLVMCVICAIGMDWETK 91
N +N++R+ G + L M ++ +G+ + K
Sbjct: 243 TSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 377 IGSFMIVADITDTALTK--GERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + + GE + + + ++ K++ F ++ ++ G L+Q+
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAE 457
GLG + N +++G+ W +E
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSE 803
Score = 41.5 bits (93), Expect = 0.011
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K + L R+
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRL 904
Query: 654 E 654
E
Sbjct: 905 E 905
>AF054506-1|AAC39685.1| 1068|Homo sapiens erythroid K:Cl
cotransporter splicing isoform 2 protein.
Length = 1068
Score = 58.0 bits (134), Expect = 1e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP GT+LA+ + YF+ V+L G
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G G+ N + L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKYGDGVSRNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEP 554
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSL-------NHLLKTHGLKI 59
GG Y+++SRSLG EFG +VG+ F AA+M +G + L + G
Sbjct: 183 GGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHD 242
Query: 60 VDN-DVNDIRIVGAVALLVMCVICAIGMDWETK 91
N +N++R+ G + L M ++ +G+ + K
Sbjct: 243 TSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 377 IGSFMIVADITDTALTK--GERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + + GE + + + ++ K++ F ++ ++ G L+Q+
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAE 457
GLG + N +++G+ W +E
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSE 803
Score = 41.5 bits (93), Expect = 0.011
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K + L R+
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRL 904
Query: 654 E 654
E
Sbjct: 905 E 905
>AF054505-1|AAC39684.1| 1011|Homo sapiens erythroid K:Cl
cotransporter splicing isoform 1 protein.
Length = 1011
Score = 58.0 bits (134), Expect = 1e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP GT+LA+ + YF+ V+L G
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G G+ N + L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKYGDGVSRNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEP 554
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSL-------NHLLKTHGLKI 59
GG Y+++SRSLG EFG +VG+ F AA+M +G + L + G
Sbjct: 183 GGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHD 242
Query: 60 VDN-DVNDIRIVGAVALLVMCVICAIGMDWETK 91
N +N++R+ G + L M ++ +G+ + K
Sbjct: 243 TSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 377 IGSFMIVADITDTALTK--GERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + + GE + + + ++ K++ F ++ ++ G L+Q+
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAE 457
GLG + N +++G+ W +E
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSE 803
Score = 41.5 bits (93), Expect = 0.011
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K + L R+
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRL 904
Query: 654 E 654
E
Sbjct: 905 E 905
>AF047338-1|AAC32815.1| 1085|Homo sapiens erythroid K:Cl
cotransporter protein.
Length = 1085
Score = 58.0 bits (134), Expect = 1e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP GT+LA+ + YF+ V+L G
Sbjct: 420 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G G+ N + L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKYGDGVSRNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIAKDNIIPFLRVFG--HGKVNGEP 554
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSL-------NHLLKTHGLKI 59
GG Y+++SRSLG EFG +VG+ F AA+M +G + L + G
Sbjct: 183 GGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHD 242
Query: 60 VDN-DVNDIRIVGAVALLVMCVICAIGMDWETK 91
N +N++R+ G + L M ++ +G+ + K
Sbjct: 243 TSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNK 275
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 661 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 720
Query: 377 IGSFMIVADITDTALTK--GERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + + GE + + + ++ K++ F ++ ++ G L+Q+
Sbjct: 721 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAE 457
GLG + N +++G+ W +E
Sbjct: 781 CGLGGMRHNSVVLGWPYGWRQSE 803
Score = 41.5 bits (93), Expect = 0.011
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K + L R+
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRL 904
Query: 654 E 654
E
Sbjct: 905 E 905
>BC132670-1|AAI32671.1| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 57.6 bits (133), Expect = 2e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDL++ +IP GT+LA+A + Y + V+L G
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFG----- 454
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G ++ N + L AW P+ I G +
Sbjct: 455 ------ACIEGVVL---RDKFGEAVNGNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 503
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 504 TGAPRLLQAISRDGIVPFLQVFG--HGKANGEP 534
Score = 51.2 bits (117), Expect = 1e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQR----PALIDVAHMLTK 376
WG G + L H++++ PQLLVL + P L+ + L
Sbjct: 641 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKA 700
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L + R + ++ K++ F ++ +L+ G + L+Q+
Sbjct: 701 GKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQS 760
Query: 435 SGLGKLSPNILLIGFKKDWTNAE-HKQISDYYGVIQDAFDLKLAVTILR 482
GLG L N +L+G+ ++W E H+ ++ ++++ LA+ + +
Sbjct: 761 GGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTK 809
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 162 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 221
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 222 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 254
Score = 40.7 bits (91), Expect = 0.019
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
+D WW+ DGG+ +LLP+++ K +RIF + + K + + L RI
Sbjct: 826 IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 884
>BC132668-1|AAI32669.1| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 57.6 bits (133), Expect = 2e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDL++ +IP GT+LA+A + Y + V+L G
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFG----- 454
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G ++ N + L AW P+ I G +
Sbjct: 455 ------ACIEGVVL---RDKFGEAVNGNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 503
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 504 TGAPRLLQAISRDGIVPFLQVFG--HGKANGEP 534
Score = 51.2 bits (117), Expect = 1e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQR----PALIDVAHMLTK 376
WG G + L H++++ PQLLVL + P L+ + L
Sbjct: 641 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKA 700
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L + R + ++ K++ F ++ +L+ G + L+Q+
Sbjct: 701 GKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQS 760
Query: 435 SGLGKLSPNILLIGFKKDWTNAE-HKQISDYYGVIQDAFDLKLAVTILR 482
GLG L N +L+G+ ++W E H+ ++ ++++ LA+ + +
Sbjct: 761 GGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTK 809
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 162 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 221
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 222 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 254
Score = 40.7 bits (91), Expect = 0.019
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
+D WW+ DGG+ +LLP+++ K +RIF + + K + + L RI
Sbjct: 826 IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 884
>BC098390-1|AAH98390.1| 1083|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 7 protein.
Length = 1083
Score = 57.6 bits (133), Expect = 2e-07
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + ++L G
Sbjct: 420 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G L N I L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKFGEALQGNLVIGML--AWPSPWVIVIGSFFSTCGAGLQSL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIARDGIVPFLQVFG--HGKANGEP 554
Score = 46.4 bits (105), Expect = 4e-04
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 6/144 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + + H H++++ PQ+LV+ A ++ P L+ L
Sbjct: 661 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 720
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L K R + K + F L+ L+ G + L+Q+
Sbjct: 721 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAEH 458
+GLG L N +L+ + W ++
Sbjct: 781 AGLGGLKHNTVLMAWPASWKQEDN 804
Score = 44.8 bits (101), Expect = 0.001
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG YY++SRSLG EFG +VG+ F A +M +G + + + G I +
Sbjct: 183 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYI-SPGAAIFQAEAAG 241
Query: 64 ------VNDIRIVGAVALLVMCVICAIGMDWETK 91
++++R+ G L++M ++ +G+ + K
Sbjct: 242 GEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNK 275
Score = 41.9 bits (94), Expect = 0.008
Identities = 17/60 (28%), Positives = 31/60 (51%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K ++ L RI
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRI 904
>AL162458-7|CAH74054.2| 1116|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 1116
Score = 57.6 bits (133), Expect = 2e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDL++ +IP GT+LA+A + Y + V+L G
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFG----- 454
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G ++ N + L AW P+ I G +
Sbjct: 455 ------ACIEGVVL---RDKFGEAVNGNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 503
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 504 TGAPRLLQAISRDGIVPFLQVFG--HGKANGEP 534
Score = 51.2 bits (117), Expect = 1e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQR----PALIDVAHMLTK 376
WG G + L H++++ PQLLVL + P L+ + L
Sbjct: 641 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKA 700
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L + R + ++ K++ F ++ +L+ G + L+Q+
Sbjct: 701 GKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQS 760
Query: 435 SGLGKLSPNILLIGFKKDWTNAE-HKQISDYYGVIQDAFDLKLAVTILR 482
GLG L N +L+G+ ++W E H+ ++ ++++ LA+ + +
Sbjct: 761 GGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTK 809
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 162 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 221
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 222 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 254
Score = 40.7 bits (91), Expect = 0.019
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
+D WW+ DGG+ +LLP+++ K +RIF + + K + + L RI
Sbjct: 826 IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 884
>AK024497-1|BAB15787.1| 721|Homo sapiens FLJ00105 protein protein.
Length = 721
Score = 57.6 bits (133), Expect = 2e-07
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + ++L G
Sbjct: 58 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFG----- 112
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G L N I L AW P+ I G +
Sbjct: 113 ------ACIEGVVL---RDKFGEALQGNLVIGML--AWPSPWVIVIGSFFSTCGAGLQSL 161
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 162 TGAPRLLQAIARDGIVPFLQVFG--HGKANGEP 192
Score = 46.4 bits (105), Expect = 4e-04
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 6/144 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + + H H++++ PQ+LV+ A ++ P L+ L
Sbjct: 299 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 358
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L K R + K + F L+ L+ G + L+Q+
Sbjct: 359 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 418
Query: 435 SGLGKLSPNILLIGFKKDWTNAEH 458
+GLG L N +L+ + W ++
Sbjct: 419 AGLGGLKHNTVLMAWPASWKQEDN 442
Score = 41.9 bits (94), Expect = 0.008
Identities = 17/60 (28%), Positives = 31/60 (51%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K ++ L RI
Sbjct: 483 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRI 542
>AK024493-1|BAB15783.1| 780|Homo sapiens FLJ00098 protein protein.
Length = 780
Score = 57.6 bits (133), Expect = 2e-07
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + ++L G
Sbjct: 117 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFG----- 171
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G L N I L AW P+ I G +
Sbjct: 172 ------ACIEGVVL---RDKFGEALQGNLVIGML--AWPSPWVIVIGSFFSTCGAGLQSL 220
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 221 TGAPRLLQAIARDGIVPFLQVFG--HGKANGEP 251
Score = 46.4 bits (105), Expect = 4e-04
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 6/144 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + + H H++++ PQ+LV+ A ++ P L+ L
Sbjct: 358 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 417
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L K R + K + F L+ L+ G + L+Q+
Sbjct: 418 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 477
Query: 435 SGLGKLSPNILLIGFKKDWTNAEH 458
+GLG L N +L+ + W ++
Sbjct: 478 AGLGGLKHNTVLMAWPASWKQEDN 501
Score = 41.9 bits (94), Expect = 0.008
Identities = 17/60 (28%), Positives = 31/60 (51%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K ++ L RI
Sbjct: 542 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRI 601
>AF208159-1|AAG43493.1| 1116|Homo sapiens electroneutral
potassium-chloride cotransporter KCC2 protein.
Length = 1116
Score = 57.6 bits (133), Expect = 2e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDL++ +IP GT+LA+A + Y + V+L G
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFG----- 454
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G ++ N + L AW P+ I G +
Sbjct: 455 ------ACIEGVVL---RDKFGEAVNGNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 503
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 504 TGAPRLLQAISRDGIVPFLQVFG--HGKANGEP 534
Score = 51.2 bits (117), Expect = 1e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQR----PALIDVAHMLTK 376
WG G + L H++++ PQLLVL + P L+ + L
Sbjct: 641 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKA 700
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L + R + ++ K++ F ++ +L+ G + L+Q+
Sbjct: 701 GKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQS 760
Query: 435 SGLGKLSPNILLIGFKKDWTNAE-HKQISDYYGVIQDAFDLKLAVTILR 482
GLG L N +L+G+ ++W E H+ ++ ++++ LA+ + +
Sbjct: 761 GGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTK 809
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 162 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 221
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 222 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 254
Score = 40.7 bits (91), Expect = 0.019
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
+D WW+ DGG+ +LLP+++ K +RIF + + K + + L RI
Sbjct: 826 IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 884
>AF105365-1|AAD39741.1| 1083|Homo sapiens K-Cl cotransporter KCC4
protein.
Length = 1083
Score = 57.6 bits (133), Expect = 2e-07
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + ++L G
Sbjct: 420 FTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFG----- 474
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G L N I L AW P+ I G +
Sbjct: 475 ------ACIEGVVL---RDKFGEALQGNLVIGML--AWPSPWVIVIGSFFSTCGAGLQTL 523
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 524 TGAPRLLQAIARDGIVPFLQVFG--HGKANGEP 554
Score = 46.4 bits (105), Expect = 4e-04
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 6/144 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + + H H++++ PQ+LV+ A ++ P L+ L
Sbjct: 661 WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKA 720
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L K R + K + F L+ L+ G + L+Q+
Sbjct: 721 GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS 780
Query: 435 SGLGKLSPNILLIGFKKDWTNAEH 458
+GLG L N +L+ + W ++
Sbjct: 781 AGLGGLKHNTVLMAWPASWKQEDN 804
Score = 44.8 bits (101), Expect = 0.001
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 10/94 (10%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG YY++SRSLG EFG +VG+ F A +M +G + + + G I +
Sbjct: 183 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYI-SPGAAIFQAEAAG 241
Query: 64 ------VNDIRIVGAVALLVMCVICAIGMDWETK 91
++++R+ G L++M ++ +G+ + K
Sbjct: 242 GEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNK 275
Score = 41.9 bits (94), Expect = 0.008
Identities = 17/60 (28%), Positives = 31/60 (51%)
Query: 594 YVDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
++D WW+ DGG+ +LLP+++ + K +RIF + + K ++ L RI
Sbjct: 845 HIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRI 904
>AB033002-1|BAA86490.1| 1101|Homo sapiens KIAA1176 protein protein.
Length = 1101
Score = 57.6 bits (133), Expect = 2e-07
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 21/153 (13%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + +YFP+VTG+ AG+N GDL++ +IP GT+LA+A + Y + V+L G
Sbjct: 392 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFG----- 446
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLMSAW-GPF-IYAGCWXXXXXXXXXXX 268
A + L + G ++ N + L AW P+ I G +
Sbjct: 447 ------ACIEGVVL---RDKFGEAVNGNLVVGTL--AWPSPWVIVIGSFFSTCGAGLQSL 495
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGR-HGEP 300
PRL+QA+ D I P L F +G+ +GEP
Sbjct: 496 TGAPRLLQAISRDGIVPFLQVFG--HGKANGEP 526
Score = 51.2 bits (117), Expect = 1e-05
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVLAGTPLQR----PALIDVAHMLTK 376
WG G + L H++++ PQLLVL + P L+ + L
Sbjct: 633 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKA 692
Query: 377 IGSFMIVADITD-TALTKGERVSRQHIG-EQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + T L + R + ++ K++ F ++ +L+ G + L+Q+
Sbjct: 693 GKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQS 752
Query: 435 SGLGKLSPNILLIGFKKDWTNAE-HKQISDYYGVIQDAFDLKLAVTILR 482
GLG L N +L+G+ ++W E H+ ++ ++++ LA+ + +
Sbjct: 753 GGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTK 801
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 154 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 213
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 214 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 246
Score = 40.7 bits (91), Expect = 0.019
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRI 653
+D WW+ DGG+ +LLP+++ K +RIF + + K + + L RI
Sbjct: 818 IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRI 876
>DQ138323-1|ABA02873.1| 1141|Homo sapiens potassium chloride
cotransporter KCC3a-S3 protein.
Length = 1141
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 476 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 530
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 531 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 579
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 580 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 610
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 717 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 776
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 777 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 836
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 837 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 885
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 241 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 301 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 333
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 902 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 961
>BC126243-1|AAI26244.1| 1099|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1099
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 434 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 488
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 489 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 537
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 538 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 568
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 675 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 734
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 735 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 794
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 795 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 843
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 291
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 860 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 919
>BC126241-1|AAI26242.1| 1099|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1099
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 434 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 488
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 489 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 537
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 538 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 568
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 675 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 734
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 735 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 794
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 795 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 843
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 291
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 860 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 919
>BC070107-1|AAH70107.2| 1091|Homo sapiens solute carrier family 12
(potassium/chloride transporters), member 6 protein.
Length = 1091
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 480
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 481 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 529
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 530 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 560
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 667 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 726
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 727 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 786
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 787 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 835
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 283
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 852 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 911
>AL117500-1|CAB55965.1| 1014|Homo sapiens hypothetical protein
protein.
Length = 1014
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 349 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 403
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 404 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 452
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 453 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 483
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 590 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 649
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 650 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 709
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 710 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 758
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 114 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 173
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 174 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 206
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 775 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 834
>AF531260-1|AAQ10028.1| 1091|Homo sapiens K-Cl cotransporter
KCC3a-S2 isoform protein.
Length = 1091
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 480
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 481 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 529
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 530 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 560
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 667 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 726
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 727 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 786
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 787 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 835
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 283
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 852 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 911
>AF531259-1|AAQ10027.1| 1091|Homo sapiens K-Cl cotransporter
KCC3a-S1 isoform protein.
Length = 1091
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 480
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 481 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 529
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 530 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 560
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 667 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 726
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 727 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 786
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 787 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 835
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 283
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 852 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 911
>AF531258-1|AAQ10026.1| 1135|Homo sapiens K-Cl cotransporter
KCC3a-X2M isoform protein.
Length = 1135
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 470 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 524
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 525 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 573
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 574 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 604
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 711 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 770
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 771 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 830
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 831 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 879
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 235 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 294
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 295 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 327
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 896 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 955
>AF477977-1|AAL85335.1| 1011|Homo sapiens K-Cl cotransporter KCC3
variant isoform protein.
Length = 1011
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 346 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 400
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 401 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 449
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 450 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 480
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 587 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 646
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 647 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 706
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 707 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 755
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 111 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 170
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 171 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 203
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 772 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 831
>AF314956-2|AAM96216.1| 1099|Homo sapiens potassium-chloride
transporter-3b protein.
Length = 1099
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 434 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 488
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 489 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 537
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 538 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 568
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 675 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 734
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 735 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 794
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 795 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 843
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 291
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 860 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 919
>AF314956-1|AAM96215.1| 1150|Homo sapiens potassium-chloride
transporter-3a protein.
Length = 1150
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 485 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 539
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 540 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 588
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 589 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 619
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 785
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 786 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 845
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 846 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 894
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 342
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 911 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 970
>AF116242-1|AAF24986.1| 1150|Homo sapiens K-Cl cotransporter KCC3
protein.
Length = 1150
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 485 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 539
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 540 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 588
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 589 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 619
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 785
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 786 GKGLTIVGSVIVGNFLHNYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 845
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 846 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 894
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 342
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 911 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 970
>AF108831-1|AAD25337.1| 1099|Homo sapiens K:Cl cotransporter 3
protein.
Length = 1099
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 434 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 488
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 489 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 537
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 538 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 568
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 675 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 734
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 735 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 794
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 795 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 843
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 199 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 258
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 259 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 291
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 860 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 919
>AF105366-1|AAD39742.1| 1150|Homo sapiens K-Cl cotransporter KCC3a
protein.
Length = 1150
Score = 52.0 bits (119), Expect = 8e-06
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 19/152 (12%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ + Y + V+L G
Sbjct: 485 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG----- 539
Query: 211 DASGNVANLTTAALESCKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXXXX 268
A + L + G + N + L S W I G +
Sbjct: 540 ------ACIEGVVL---RDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQSL 588
Query: 269 XXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 589 TGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 619
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 785
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 786 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 845
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 846 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 894
Score = 46.0 bits (104), Expect = 5e-04
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCDSLNHLLKTHGLKIVDND--- 63
GG Y+++SR+LG EFG +VG+ F AA+M +G + + +D
Sbjct: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 342
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 911 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 970
>BC051744-1|AAH51744.1| 943|Homo sapiens SLC12A6 protein protein.
Length = 943
Score = 49.6 bits (113), Expect = 4e-05
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Query: 321 WGSSTEGQRYQDTVSFITELSHRVTHSRSYNPQLLVL----AGTPLQRPALIDVAHMLTK 376
WG G + L H++++ PQLLVL ++ P L+ A L
Sbjct: 668 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 727
Query: 377 IGSFMIVADIT--DTALTKGERVSRQHIGEQFVKYRKLRAFYVLLQGLDLKRGANALMQA 434
IV + + GE ++ + + ++ K++ F L+ L+ G + L+Q+
Sbjct: 728 GKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQS 787
Query: 435 SGLGKLSPNILLIGFKKDWTNAEHKQI-SDYYGVIQDAFDLKLAVTILR 482
GLG + N +++G+ W +E + + G ++ LA+ + +
Sbjct: 788 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAK 836
Score = 48.4 bits (110), Expect = 9e-05
Identities = 47/154 (30%), Positives = 68/154 (44%), Gaps = 22/154 (14%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDLK+ +IP GT+LA+ +T+ F +
Sbjct: 426 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAI---LTTSFVL---------- 472
Query: 211 DASGNVANLTTAALES--CKPHCGYGLHNNYAIMQLM--SAWGPFIYAGCWXXXXXXXXX 266
D S V L A +E + G + N + L S W I G +
Sbjct: 473 DLSNVV--LFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPW--VIVIGSFFSTCGAGLQ 528
Query: 267 XXXXVPRLIQALGVDRIYPGLIFFSKPYGRHGEP 300
PRL+QA+ D I P L F +GEP
Sbjct: 529 SLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEP 561
Score = 46.0 bits (104), Expect = 5e-04
Identities = 28/93 (30%), Positives = 50/93 (53%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLL-------KTHGLK 58
GG Y+++SR+LG EFG +VG+ F AA+M +G + L +++ LK
Sbjct: 191 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 250
Query: 59 IVDNDVNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L++M ++ IG+ + K
Sbjct: 251 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNK 283
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 595 VDAWWLYEDGGLNILLPYIIARRGYKHKLPLRIFAITKEQHKREFENKCMESLLKKFRIE 654
+D WW+ DGG+ +LLP+++ + K +RIF + + + K + + L RIE
Sbjct: 853 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE 912
>AL162458-6|CAH74053.1| 285|Homo sapiens solute carrier family 12,
(potassium-chloride transporter) member 5 protein.
Length = 285
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIGFCD-SLNHLLKTHGL-KIVDND- 63
GG YY++SRSLG EFG +VG+ F A +M +G + L +L + K D
Sbjct: 162 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASG 221
Query: 64 -----VNDIRIVGAVALLVMCVICAIGMDWETK 91
+N++R+ G L M + +G+ + K
Sbjct: 222 EAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNK 254
>BX538023-1|CAD97969.1| 525|Homo sapiens hypothetical protein
protein.
Length = 525
Score = 45.6 bits (103), Expect = 7e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 162 VTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDA 212
++GV AG N+ GDL+ PA +IP G+L A+ IS Y V L G R+A
Sbjct: 55 LSGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 105
>BC007760-1|AAH07760.1| 266|Homo sapiens SLC12A7 protein protein.
Length = 266
Score = 43.6 bits (98), Expect = 0.003
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 7 GGVYYLVSRSLGAEFGASVGILFAFANAVAASMNTIG 43
GG YY++SRSLG EFG +VG+ F A +M +G
Sbjct: 183 GGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
>AF053402-1|AAC35282.1| 238|Homo sapiens erythrocyte K-Cl
cotransporter protein.
Length = 238
Score = 38.3 bits (85), Expect = 0.10
Identities = 21/60 (35%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Query: 151 FFSVFAVYFPAVTGVQAGANICGDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALR 210
F + ++FP+VTG+ AG+N GDL++ +IP G ++ + S + V S + ALR
Sbjct: 141 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGPFWP-SLQLPSCTSAVWFSLVPALR 199
>BC063528-1|AAH63528.1| 338|Homo sapiens SLC12A8 protein protein.
Length = 338
Score = 35.9 bits (79), Expect = 0.54
Identities = 18/40 (45%), Positives = 23/40 (57%)
Query: 173 GDLKNPAVAIPKGTLLALAISVTSYFTMVILSGMGALRDA 212
GDL+ PA +IP G+L A+ IS Y V L G R+A
Sbjct: 3 GDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA 42
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.136 0.409
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 97,599,709
Number of Sequences: 224733
Number of extensions: 3572464
Number of successful extensions: 9158
Number of sequences better than 10.0: 59
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 8829
Number of HSP's gapped (non-prelim): 253
length of query: 767
length of database: 73,234,838
effective HSP length: 96
effective length of query: 671
effective length of database: 51,660,470
effective search space: 34664175370
effective search space used: 34664175370
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 69 (31.9 bits)
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